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text: Breadcrumb Home > Thesaurus > Q Cite Synonyms of quest after Find synonyms for: Verb1. quest for, go after, quest after, pursue, search, seek, look forusage: go in search of or hunt for; "pursue a hobby"WordNet 3.0 Copyright © 2006 by Princeton University. All rights reserved. TrendingHere are the facts and trivia that people are buzzing about. November 2020 Current Events: US News How U.S. Presidential Elections Work The History of Black Friday The Top 8 3D Printers This List of Favorite Islands will Make You Remember Why You Loved Poptropica So Much Winter Holiday Roundup Related Content Daily Word Quiz: frisson Analogy of the Day: Today's Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language

subset: commoncrawl


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Nov 26 - Nov 27
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Nov 27 - Nov 28
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Dec 1 - Dec 2
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My family and I decided to take a vacation last week to this hotel. for the price (225USD per night per room, we got two rooms), we thought it was going to be a premium vacation and fancy place. Nothing of that! What we got was two standard rooms, one of which had the bath tub broken, the bath room ...
Hotels in Argentine Northwest start at $40 per night. Prices and availability subject to change. Additional terms may apply.
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- Bearsbridge is a Village in Northumberland.
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Make your own soap and deodorant during the Workshop Natural Cosmetics at Spanje Creatief
How nice is it to use homemade natural soap and deodorant. During the Workshop Natural Cosmetics we are going to make soap using, among other things, olive oil according to the cold process. You will also learn how to make deodorant with natural ingredients. Natural cosmetics are not only better for your skin, it also saves the planet ...
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Connacht prop Robbie Morris has officially announced his retirement as a result of a back injury.
The former English international played his last game for the province against Toulon in last season's Amlin Cup semi-final, having played 39 Magners League games for Connacht since joining in 2007 from Newcastle.
Connacht coach and former Irish International Eric Elwood said the 28-years-old Morris was "a true professional". " In the three years Robbie has been with us, he has made a huge impression on everyone. He is a well liked member of the squad, and the work he has done helping to bring the younger members through has been invaluable."
Morris, who was capped for England in 2003 against Wales, is currently involved with Galwegians u-21s, in addition to helping Connacht forward coach Dan McFarland.
"I've always tried to help out the younger players," says Morris, " and since I've been injured I've had more time to dedicate to going through the analysis, watch them at training, and offering advice where it's needed. There's some great young props coming through, the likes of Brett Wilkinson and Jamie Hagan who've had a taste of the Irish squad and hopefully they'll go on to get full caps and carry on from there."


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President Moon Jae-in took part Sunday in a virtual summit of the G-20.
And there, he emphasized the importance of global cooperation to overcome the economic and health crises posed by the COVID-19 pandemic.
To that end, he again called on countries to step up essential travel… so their economies can recover.
Kim Min-ji reports.
At Saturday's virtually-held G20 Summit,… President Moon Jae-in reiterated the importance of facilitating travel for essential people to ensure a swift recovery of the global economy.
This was the first day of a two-day meeting, and it was held under the theme of "Overcoming the pandemic and restoring growth and jobs."
Moon again highlighted the need for solidarity and cooperation in the international community.
I hope for the smooth exchange of personnel and essential goods. In particular, I look forward to more active exchanges between countries by expanding fast-track entry procedures.
Moon also stressed the need for fair and equal distribution of treatment and vaccines to put a complete end to the COVID-19 pandemic.
He promised cooperation on Seoul's part to supply vaccines to developing countries.
South Korea is joining in the efforts of the World Health Organization for fair access to vaccines. We will also expand cooperation and humanitarian assistance through the Seoul-based International Vaccine Institute.
The leaders of the G20 will meet again on Sunday for the last session under the theme of 'Building an inclusive, sustainable and resilient future.'
Following the summit, they will adopt a joint statement.
Kim Min-ji, Arirang News.
#President_Moon #SUMMIT #G20
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What Give Treatment for fungal infection?
Here Shown in picture . infection on Groin .most common in Men . 35 year men .suffering from liver disease like (jaundice) Temp - 35°C and 97.3 In Fahrenheit. BP - Sys -128mmhg dys- 86mmhg Pulse - 89 Spo2% - 104 Per abdomen - Soft Chief Complaints itching , dry skin, scaly on Cutaneous layer . Vitals Minor Migraine , Cholesterol, heartburn Diagnosis What is the diagnosis for the PATIENT? Suggest?? Rx?
Tinea corporis Dry skin, liver affection, itching indicate lycopodium, if other symptoms indicate think about it
Too much heat in the body. Needs counselling calmness symphony music,a healthy marital relationship, beetroot coriander juice...after tending liver,,... apricots carrots pomegranates figs dates sprouts kalijeeri alkaline diet walnuts blue berries sunshine ginger muskmelon no tomatoes in cooking.. raw tomatoes... cabbage juice pineapple with black pepper citrus fruit lemongrass decoction drumstick soup..jeera.inhalation physio under supervision of Doctor...sulpha if tolerant turmeric powder paste cold pressed coconut oil massage and in naval..God bless him... prayers
Locally apply neem bark decoction + Haridra powder at time of sleeping Vry effective after 4-5 days you can see the results Internally Arogyabardhini vati 2tab BD Brihat haridra khanda 6gm BD empty stomach Manjisthadi kwath 15ml +15ml water after lunch and dinner
Phalatrikadi kadha 3 tsp bd Nirocil tab 1 tds Arogyavardhini 1 tds Six c ointment for local application
Ring worm. Sepia 30
Dx Tenia cruris (Ring worm) Rx Sulphur 1m od. After 24 hour. Sepia 200 BD/3 days.
Rx-Sulphur 200 -1dose BF
Ring worm and can try rhus tox
Rx majun ushba Shbt unnab Itrifal sahtra
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25yrs male with this type of skin lesions on back & front, groin With itching dryness darkness and roughness Please explain thanksDr. Kute Ankush0 Like19 Answers
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52 yrs old male pt with c/o itching all over body with recurrent eruption with watery discharge . ..since 5 mnths... no h/o diabetes. .. treated with tab flucanzole(150).tab atrax 10mg .cream betnovate-n..tab.amoxclav... investigation- IgE negative.... plz diagnose nd guideDr. Mahesh Deshmukh3 Likes19 Answers
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7 year boy having recurrent these type of skin lesion in both legs ...........spreading in nature. itching +.diagnosis and treatment plz.Dr. Venkatesh Pujar4 Likes32 Answers
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10 yr child with these lesion all over the body.. Itching present.. What is Dx and Rx..?Dr. Shivaji Mhaske1 Like23 Answers
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Spot diagnosis and management. lady having these leisons since 2 months. No DM, no hypertension.Dr. Arjun Singh Shekhawat3 Likes29 Answers


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Some owners ask us for a confidential displaying of their properties, so they are not visible on our sites.
Correze - Objat - Anything is possible here
In a small hamlet a large red sandstone barn with slate roof on 799 m² of flat land.
Situated on the edge of a small village not far from the commercial town of Objat this barn could be converted into a house. It offers two compartments, one of 102 m² and the other of 74 m² which allows you to keep part of it as a workshop or garage. There's equally a lean-to of about 60 m². Lovely view at the back, flat garden of 799 m² and two entrances. Water and electricity are running in front of the house. Brive 20 min. ...
Ref. : AY1255
Correze - Saint-Robert - Town house in Saint-Robert for renovation.
At walking distance of restaurant and bars an old stone house for renovation with an attached barn.
Vaulted cellar and 2 cellars on the ground floor from which one is serving as a boiler room.On the elevated ground floor a kitchen and living room both equiped with a fireplace.On the first floor two bedrooms.The house needs full renovation although the roof is in fairly good condition. Centrale heating oil fired and connected to mains sewerage.The house offers 50 m² of livable space with the possibility to extend into the barn. Approx. 100 m² is possible and why not make a South facing internal terrace in the barn. Brive 30 KmYour contact : Agence Van den berg Immobilier (0033) 0 555 25 28 00 Pieter Van den berg firstname.lastname@example.com professionnelle n° CPI 19012017000020449 CCI de ...
Ref. : AY673
Dordogne - Hautefort - Stunning stone-built house with possibilities.
This property (117 m²) on the edge of a hamlet offers a two-bedroom house, a large barn, on land of 545 m².
This cute two-bedroom stone-built house offers at the ground floor a lounge of 28 m², a bedroom, a kitchen of 30 m², a bathroom. A second part of the property for the moment only accessible by outside, there's a possibility to communicate the two parts here we find a 35 m² room. Upstairs a convertible attic of 25 m². Further a barn of 85 m² floor space over two levels. Lovely courtyard, which can be a stunning private place. Gaz fired heating system, the property is for renovation roof and walls are in good condition. Land of 545 m². Hautefort 10 min. Saint Robert 10 min. ...
Ref. : AY1122
Correze - Ayen - Walnut plantation with building permission.
Superb building plot of 4 780 m² on the edge of the desirable village of Ayen.
A large flat building section planted with walnut trees giving you the opportunity to build one or severalhouses without having neighbors nearby. ...
Ref. : AY1195
Correze - Arnac Pompadour - Cute little stone-built house.
Stone built house offering 110 m² of living space and a cellar on a plot of land of 819 m².
The house offers a cellar and on the ground floor a kitchen of 9 m², a lounge/ dining room of 25 m² with fireplace, two bedrooms (13,14 m²), a bath room with WC and a corridor who leads you to the first floor. Upstairs two bed rooms of 30 and 10 m². Nice flat land of 819 m² with a well for your garden water Heating by a wood burner. Pompadour 10 min. Brive 35 min. ...
Ref. : AY1045
Correze - Ayen - A beautiful house for renovation.
A town house offering an ancient shop (70m²) on the ground floor as well as an apartment
For renovation above.
The ground floor offers 70 m² of possible living space and a stunning vaulted cellar.At the first-floor the apartment with a landing, a bright living room of 30 m², a kitchen of 14 m², a bed room of 15 m², shower room and separate WC.At the second floor a convertible attic of 45 m².Great views over the Ayen valley.Heating; electric radiatorsMains sewerage.Objat 10 minutes.Brive 20 minutes Your contact : Agence Van den berg Immobilier (0033) 0 555 25 28 00 email@example.com firstname.lastname@example.com Verboom firstname.lastname@example.com mobile : (0033) 0 18.104.22.168.29Carte professionnelle n° CPI 19012017000020449 CCI de Brive-la GaillardeAttestation collaborateur ADC ...
Ref. : AY910
Correze - Saint-Robert - A mini house on land of 3 300 m².
A tiny house that could be extended and made into a real home.
Lovely spot for this little house offering one room with an inglenook fireplace and attic above. The currentowner has obtained a building permission to extend the little house with an extra 95 m².A septic tank has been installed and water and electricity are connected.Beautiful flat piece of land at the back and the side of the property surrounded by woods.A mobile home has been installed which is included in the sale.Small price for this little cottage offering many possibilities. St-Robert 5 minutes ...
Ref. : AY1094
Corrèze - Lascaux - Chalet in the middle of the forest.
Comfortable chalet with terrace, surrounded by forest on land of 1 876m² with a stunning view.
Chalet built in the seventies and updated since offering a lounge of 17 m² with open plan kitchen , two bedrooms and a bathroom with toilet. Beautiful 15 m² terrace.Equally a small independent chalet having an extra double bedroom.Landsize 1 876 m² and great views. Pompadour : 10 minObjat : 10 min ...
Ref. : AY1176
Correze - Objat - A well proportioned home.
A character house to renovate with a superb vaulted cellar, garden and garage at an affordable price and not far from the commercial busy market town of Objat.
Located in the quiet village of Vars sur roseix, a beautiful stone-built house with a living area of approximately 125 m².It offers on the ground floor an entrance hall leading to a 16 m² kitchen with inglenook fireplace, a 38 m² lounge/dining room with fireplace as well as a bathroom, WC and a corridor.Upstairs a corridor, two landings and three large bedrooms (9.80, 12, 17.60 m²).Beautiful convertible attic of 45 m² effective (mesured at 1.80 m).Garage, courtyard and lovely garden, total surface area of the land 462 m². Partly double glazed, connected to the mains drainage, heating ; wood and electric. Objat 5 min.Brive 20 min. ...
Ref. : AY1218
Correze - Perpezac-le-Blanc - Building plot in the middle of the woods.
Superb building plot with a parcel of woodland of approximately 4,5 acres.
Here you have the possibility to build a house in a natural environment surrounded by adult mainly oak trees and to enjoy the great view.On this parcel of 4,5 acres there's around 700 m² constructible, the land is accessible by a track maintained by the mairie. Ayen 5 minutes and Brive at 20 minutes ...
Ref. : AY988
Old house | New built house | Barn for conversion | Waterproperty | Farm | Small farm | Business | Prestigious properties | Land | Building plot | Hamlet | Apartment |


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How to Tell if someone Has Blocked Me On Facebook - Best Way to Track It
By pusahma2008 — Saturday, November 7, 2020 — Who Blocked Me On Facebook
Yet while there's no apparent status message on Facebook that validates you have actually been blocked by a person, there are some indicators you can check for to figure it out on your own.
How To Tell If Someone Has Blocked Me On Facebook
When a person blocks you, several of the signs resemble being unfriended. Here are some points you will see:
- They're not in your Pals checklist. If you are good friends with the person as well as they've gone away from your buddies listing, it either indicates they have unfriended you or blocked you. To check, most likely to your very own profile web page (on the internet, click on your name on top of the screen, or on your phone, tap the three straight lines to open up the menu as well as touch your name. Then check your Friends).
- You can't tag that person in posts. If you are friends with this person, you should be able to tag them in a blog post-- if you can't, it either means they have unfriended you or blocked you. Produce a post and also either click or touch "Tag People." Enter their name; if the name does not appear and also allow you choose it, that's a strong signal.
- You can't invite that person to events or groups. Furthermore, if you develop an event (on the web, click "events" and then "Create Event;" on your phone, touch the three straight lines, faucet "events," and after that tap "Create") and also locate that you can't invite the individual, they've unfriended or blocked you.
- You can no longer see their posts in your Facebook feed. Lastly, if you had actually been friends and also their articles no more inhabit your Facebook feed, that's an indicator of unfriending or obstructing.
There are 3 various other fairly clear indicators that you've been blocked.
- You can not find the person in search. Usually, you need to be able to find any type of Facebook individual by inputting their name in the search box at the top of Facebook's website. If you enter their name in the search box and also they no more show up, though, that's a sign that person is blocking you.
- You can not send out the person messages in Facebook Carrier. If you were formerly buddies as well as try to send out a message, you will see a mistake message that claims the user is unavailable.
- You can't see the individual's account page. If you attempt to navigate straight to his/her account page (such as by clicking their name in a Facebook Carrier home window), Facebook will certainly show a mistake that says the individual is not available.
Final thought
That's How To Tell If Someone Has Blocked Me On Facebook. Quickly to learn that is blocking your Facebook account is: They're not in your Buddies listing, you can't label that person in articles, you can't welcome that individual to events or groups, you can no more see their articles in your Facebook feed. There are three other rather clear signs that you've been blocked: You can't find the individual in search, you can't send the person messages in Facebook Messenger, you can't see the person's account web page.


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So i just recieved my checks from Home depot?
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How many candlesticks have you lost?
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So i just recieved my checks from Home depot?
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why try if we all die?
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i have no drive to do anything. all i expect out of life is to cover expenses. i'm within a year of graduating with my BS in marketing and i'm lost as to what i want to do.3 AnswersMarketing & Sales1 decade ago
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can't own firearms. ADHD really isn't dangerous to anyone even if you gave a person with ADHD a firearm they are no more a danger to society then a normal person.4 AnswersLaw & Ethics1 decade ago
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something tells me this ain't normal. but i've always viewed gettin my college degree more important then addressing this issue. what do you all think is wrong with me?8 AnswersMen's Health1 decade ago
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i'm just curious not for any particular reason.3 AnswersLaw & Ethics1 decade ago
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Day quil puts me to sleep.
nyquil wakes me up
i must be a freak.3 AnswersOther - Health1 decade ago
i've got a wisdom tooth?
that i can see into in the back of my mouth i'm thinking i should probably just go ahead and yank it or perform emergency surgery myself since i can't afford the dentist. i'm thinking i should get nice and drunk then yank the thing.8 AnswersDental1 decade ago
what cna i do with a marketing degree?
with a minor in Finance.3 AnswersMarketing & Sales1 decade ago
Anyone notice the Old School uniforms in Madden this year?
most notably the New york Titans ( jets) and the Yellow and blue eagles uniform and the Yellow helmet steelers which was actually wore for one year before they went to the traditional black on black.3 AnswersFootball (American)1 decade ago
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anyone got a guess?
BTW: i'm talking about the 300 from 1957.2 AnswersChrysler1 decade ago
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The Imperial or the Caddy.4 AnswersOther - Cars & Transportation1 decade ago
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well? which one? i play in the big 12 in my NCAA 08.4 AnswersFootball (American)1 decade ago
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well? which one?2 AnswersSingles & Dating1 decade ago
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Military research paper
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Help with writing college essays and term papers. Database of pre written reports and papers. Custom writing services.
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Military Research Papers discuss the roll that the military plays in national security, both in the past and today. Paper Masters has former Veterans and expert researchers in Military research that are available for custom writing on general military topics, military battles and military strategy.
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Editorial Features
Trend 5: Sustainable Solutions
The WNWN 2020 Trend Report features the top nine design trends for today as told by the WNWN Ambassadors, a group of 94 designers from across the country. From prioritizing a sense of calm at home to creating mixed period style interiors, these nine trends will reign supreme through 2020 and 2021.
In recent years, sustainable alternatives has become more of a "need to have" versus a "nice to have" for both designers and consumers. In fact, according to a recent Nielson study, 72% of millennials and Gen Zers say they would be willing to pay more for sustainable products. Read on to learn why our WNWN Ambassadors predict green design will remain among the top trends this year.
"As part of my profession, I must always look three years into the future because design is an ever-changing world. By the time my work is photographed, it needs to be just as relevant. I am now seeing that our future in interior design will revolve completely around sustainability. Sourcing locally, optimizing renewable resources, and incorporating solar panels in all designs will be what's happening next."
–Adam Hunter of Adam Hunter, Inc.
"2020 has strengthened the importance of our homes. They're places of shelter again (like they always used to be). We've spent more time in them, and they've become more multifunctional: home-schools, workplaces, sanctuaries. All of which places extra emphasis on home design. Aesthetics aren't enough, we need to think through space, functionality, life. With so much uncertainty as we head forward, I'm pretty certain that this trend will only continue. We'll move from superficial trends to more profound and intrinsic ones, with a greater emphasis on nature, well-being and sustainability."
–Nina Barnieh-Blair of Nina B Design
"Sustainability and wellness in interiors are becoming increasingly important. The pause created by the COVID pandemic made people even more aware of the impact our choices have on the environment; a silver lining of sorts."
–Anelle Gandelman of A-List Interiors
"The future of interior design is the expressive home; spaces that assert the ideas and values of the client. This will look like many different things, but it still embraces tradition, perhaps in unexpected ways, because it is the bedrock of who we are. We professionals have at our disposal enormous options in materials and objects; they can be functional and comfortable while telling a beautiful story. But above all, it will be sustainable."
–John Douglas Eason of John Douglas Eason Interiors
"How important have our homes become! For rest, enjoyment, family, safety and now, more than ever, work. A totally fresh look on how individuals look at their environments across all socio-economic groups is just beginning. Everything from the kitchen to the home office, to dedicated video chat spaces – our homes will continue to grow in importance as an asset for all of us and our families."
–Frank Ponterio of Frank Ponterio


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Linda Smith-Resar Lab
The Linda Smith-Resar Lab primarily investigates hematologic malignancy and molecular mechanisms that lead to cancer as well as sickle cell anemia. Recent studies suggest that education is an important and effective component of a patient blood management program and that computerized provider order entry algorithms may serve to maintain compliance with evidence-based transfusion guidelines. Another recent study indicated that colonic epithelial cells undergo metabolic reprogramming during their evolution to colorectal cancer, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention.Lab Website
Principal Investigator
Machine Biointerface Lab
Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medical Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.
Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.
M...edical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
view lessLab Website
Principal Investigator
Mark Levis Laboratory
Our broad research goals are to identify and validate novel molecular therapeutic targets in hematopoietic malignancies. We are interested in the identification and pre-clinical development of novel targeted therapies, and, in particular, the "translational" step of this research by using correlative studies to incorporate these novel therapies into existing treatments. Our research is of particular interest to those who wish to be involved in directly translating the results of laboratory bench work into meaningful benefits for patients.
Currently, we are actively involved in the pre-clinical and clinical development of small molecule kinase inhibitors targeting the FLT3 signaling pathway in acute myeloid leukemia. We are interested in 3 compounds in particular- AC220, a FLT3/KIT inhibitor; crenolanib,a selective FLT3 inhibitor with activity against resistant point mutations; and PLX3397, another inhibitor of KIT and FLT3. The active projects in the lab include:
1) Characterizati...on of cytotoxic responses of different hematologic malignancies to FLT3 and KIT kinase inhibition; 2) Examination of the interaction of bone marrow stroma and stroma-derived cytokines on the efficacy of these inhibitors; 3) Examination of the differential effect of FLT3 inhibition versus combined FLT3/KIT inhibition on acute myeloid leukemia and bone marrow progenitor cells; and 4) Correlative laboratory studies using blood and marrow samples from patients treated with FLT3 inhibitors, with the aim of developing predictive models for clinical response. view lessLab Website
Principal Investigator
Nicholas Flavahan Lab
The Nicholas Flavahan Lab primarily researches the cellular interactions and subcellular signaling pathways that control normal vascular function and regulate the initiation of vascular disease. We use biochemical and molecular analyses of cellular mediators and cell signaling mechanisms in cultured vascular cells, while also conducting physiological assessments and fluorescent microscopic imaging of signaling systems in isolated blood vessels. A major component of our research involves aterioles, tiny blood vessles that are responsible for controlling the peripheral resistance of the cardiovascular system, which help determine organ blood flow.Lab Website
Principal Investigator
Nicholas Flavahan, M.Sc., Ph.D.
Ocular Vasculogenesis and Angiogenesis Lab (OVAL)
The lab studies the development of blood vessels in the eye and how they change in diseases like retinopathy of prematurity, sickle cell and diabetic retinopathies, and age-related macular degeneration (AMD). The ultimate goal of the lab is to develop a new generation of therapies that, when delivered to the eye, allow the tissues of the eye to essentially treat themselves only when needed. The goal is to have the tissues generate their own therapeutics when needed, and stop production when the condition is resolved. These therapies will help reduce the need for repeated treatment and provide focused therapy, rather than treating the body with chemicals.Lab Website
Principal Investigator
Paul Rothman Lab
Research in the Paul Rothman Lab has focused on cytokines. We've investigated the role these molecules play in the normal development of blood cells as well as the abnormal blood-cell development that leads to leukemia. We've also studied the function of cytokines in immune system responses to asthma and allergies.Lab Website
Principal Investigator
Peter Abadir Lab
Research in the Peter Abadir Lab focuses on the renin-angiotensin system (RAS), a signaling pathway that regulates blood pressure and has been linked independently to both aging and inflammation. We're particularly interested in changes in RAS that occur with aging. We also study signal transduction and the role of the crosstalk between angiotensin II receptor in aging and are interested in understanding the function of angiotensin II in the process of vascular aging.
Principal Investigator
Peter Agre Lab
Work in the Peter Agre Lab focuses on the molecular makeup of human diseases, particularly malaria, hemolytic anemias and blood group antigens. In 2003, Dr. Agre earned the Nobel Prize in Chemistry for discovering aquaporin water channels. Building on that discovery, our recent research has included studies on the protective role of the brain water channel AQP4 in murine cerebral malaria, as well as defective urinary-concentrating ability as a result of a complete deficiency in aquaporin-1. We also collaborate on scientific training and research efforts with 20 Baltimore-area labs and in field studies in Zambia and Zimbabwe.
Principal Investigator
Pluznick Lab
The Pluznick Lab is interested in the role that chemosensation plays in regulating physiological processes, particularly in the kidney and the cardiovascular system. We have found that sensory receptors (olfactory receptors, taste receptors, and other G-protein coupled receptors) are expressed in the kidney and in blood vessels, and that individual receptors play functional roles in whole-animal physiology. We are currently working to identify the full complement of sensory receptors found in the kidney, and are working to understand the role that each receptor plays in whole-animal physiology by using a variety of in vitro (receptor localization, ligand screening) and in vivo (whole-animal physiology) techniques.Lab Website
Principal Investigator
Raymond Koehler Lab
Research in the Raymond Koehler Lab explores cerebrovascular physiology and cerebral ischemic injury caused by stroke and cardiac arrest, using protein analysis, immunohistochemistry and histology. We also study ischemic preconditioning, neonatal hypoxic-ischemic encephalopathy and the mechanisms of abnormal cerebrovascular reactivity after ischemia. We 're examining ways to improve tissue oxygenation and seek to better understand the mechanisms that connect an increase in cerebral blood flow to neuronal activity.Lab Website
Principal Investigator
Richard John Jones Lab
The Richard J. Jones Lab studies normal and cancerous stem cells in order to make clinical improvements in areas such as blood and marrow transplantation (BMT). We discovered one of the most common stem-cell markers, Aldefluor, which identifies cells based on their expression of aldehyde dehydrogenase 1 (ALDH1), and have used this marker to detect and characterize normal stem cells and cancer stem cells from many hematologic malignancies. We also developed post-transplant cyclophosphamide and effective related haploidentical BMT.
Principal Investigator
Rita Kalyani Lab
Research in the Rita Kalyani Lab examines the decreased physical functioning observed in patients with diabetes as they age. Through several ongoing epidemiological cohorts, we are investigating the association of high blood glucose and high insulin levels with accelerated muscle loss, and possible contributions to the physical disability observed in diabetes. We are currently involved in clinical studies that aim to understand the underlying mechanisms for these associations and to facilitate the development of novel strategies to prevent muscle loss and disability in people with diabetes.
Principal Investigator
Romsai Boonyasai Lab
Research in the Romsai Boonyasai Lab focuses on systems-based approaches for improving health care quality, including reducing harm during care transitions after hospital discharge and improving outcomes related to hypertension and other chronic diseases. We recently have focused on developing and evaluating practice-based tools for improving the accuracy of blood pressure measurement, overcoming clinical inertia to treatment, and engaging patients in self-management of their health.Lab Website
Principal Investigator
Romsai Boonyasai, M.D., M.P.H.
Samuel R. Denmeade Laboratory
The main research goals of my laboratory are: (1) to identify and study the biology of novel cancer selective targets whose enzymatic function can be exploited for therapeutic and diagnostic purposes; (2) to develop methods to target novel agents for activiation by these cancer selective targets while avoiding or minimizing systemic toxicity; (3) to develop novel agents for imaging cancer sites at earliest stages. To accomplish these objectives the lab has originally focused on the development of prodrugs or protoxins that are inactive when given systemically via the blood and only become activated by tumor or tissue specific proteases present within sites of tumor. Using this approach, we are developing therapies targeted for activation by the serine proteases prostate-specific antigen (PSA), human glandular kallikrein 2 (hK2) and fibroblast activation protein (FAP) as well as the membrane carboxypeptidase prostate-specific membrane antigen (PSMA). One such approach developed in the l...ab consists of a potent bacterial protoxin that we have reengineered to be selectively activated by PSA within the Prostate. This PSA-activated toxin is currently being tested clinically as treatment for men with recurrent prostate cancer following radiation therapy. In a related approach, a novel peptide-cytotoxin prodrug candidate that is activated by PSMA has been identified and is this prodrug candidate is now entering early phase clinical development. In addition, we have also identified a series of potent inhibitors of PSA that are now under study as drug targeting and imaging agents to be used in the treatment and detection of prostate cancer.
view moreLab Website
Principal Investigator
Sarbjit Saini Lab
The research in the Sarbjit Saini Laboratory focuses on IgE receptor biology and IgE receptor-mediated activation of blood basophils and mast cells. We have examined the role of IgE receptor expression and activation in allergic airways disease, anaphylaxis and chronic urticaria. Our research has been supported by the NIH, American Lung Association and the AAAAI. Our current research interests have focused mechanisms of diease in allergic asthma, allergic rhinitis and also translational studies in chronic idiopathic urticaria.
Principal Investigator
Sean T. Prigge Lab
Current research in the Sean T. Prigge Lab explores the biochemical pathways found in the apicoplast, an essential organelle found in malaria parasites, using a combination of cell biology and genetic, biophysical and biochemical techniques. We are particularly focused on the pathways used for the biosynthesis and modification of fatty acids and associated enzyme cofactors, including pantothenate, lipoic acid, biotin and iron-sulfur clusters. We want to better understand how the cofactors are acquired and used, and whether they are essential for the growth of blood-stage malaria parasites.
Principal Investigator
Sharon Turban Lab
Research in the Sharon Turban Lab focuses on the effects of sodium and potassium on blood pressure and on kidney function. We lead the Chronic Kidney Disease-Potassium (CKD-K) clinical trial, funded by American Heart Association, which examines the benefits and safety of two levels of potassium intake in patients with kidney disease. Other research includes the Chronic Renal Insufficiency Cohort (CRIC) study, which aims to improve the understanding of chronic kidney disease and related cardiovascular illness.
Principal Investigator
Steven Frank Lab
Research in the Steven Frank Lab focuses on processes to improve blood use and to avoid blood transfusions for patients who do not want to receive blood or blood products. Processes include autologous hemodilution and cell salvage, and treating or averting anemia pre- and post-surgery. Other lab studies have focused on blood conservation, bloodless medicine surgery, the regulation of body temperature during surgery and methods of preventing hypothermia during surgery.
Principal Investigator
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RECOVERY? The non-manufacturing index rose to 54.4 last month, ending four months of decline, with service firms optimistic about prospects six months ahead
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The downturn in Taiwan's manufacturing industry eased last month while service-oriented firms saw a solid boost, fueling hope that the negative impact from the COVID-19 pandemic might have touched bottom, the Chung-Hua Institution for Economic Research (CIER, 中華經濟研究院) said yesterday.
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Ride to Detroit tomorrow. Meet here. https://www.mapquest.com/us/oregon/b...tile-303903774 at 10:00 KSU at 10:15. We will ride through Sandy to Estacada then on to Detroit for gas and food. Ride back same. I'll wait at all turns so no one gets left behind.
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