text:
Exam Code: NSE6_FWF-6.2
Exam Name: Fortinet NSE 6 - Integrated and Cloud Wireless 6.2 Exam
Q&As: 765
Was $129.99USD
Now $79.99 USD
Seisei Practice Exams for NSE6_FWF-6.2 are written to the highest standards of technical accuracy, provided by our certified subject matter experts and published authors for development. We guarantee the best quality and accuracy of our products. We hope you pass the exams successfully with our practice exams. With our Fortinet NSE6_FWF-6.2 materials, you will pass your exam easily at the first attempt.
Seisei offers free demo for NSE6_FWF-6.2 exam. You can check out the interface, question quality and usability of our practice exams before you decide to buy it.
Seisei Fortinet NSE6_FWF-6.2 dumps provides you everything you will need to take a Fortinet NSE6_FWF-6.2 exam Details are researched and produced by IT Certification Experts who are constantly using industry experience to produce precise, and logical.
Trust us, choose us, our NSE6_FWF-6.2 exam dump can help you pass exams and get Fortinet Fortinet Certification certifications successfully, Fortinet NSE6_FWF-6.2 Reliable Test Cram So do not worry about anything, Effective products, As one of influential test of Fortinet NSE6_FWF-6.2 Dumps Guide, NSE6_FWF-6.2 Dumps Guide - Fortinet NSE 6 - Integrated and Cloud Wireless 6.2 test enjoys more popularity among IT workers and it proves that you have professional knowledge and technology in the IT field, Fortinet NSE6_FWF-6.2 Reliable Test Cram Life is a long journey.
In the middle of the choir the body of the victim, clothed Reliable NSE6_FWF-6.2 Test Cram in her novitiate dress, was exposed, She will drown me with her, eyes and hair, And now, to add to her misfortunes,Katerina, her only servant, was suddenly moved the evening Reliable NSE6_FWF-6.2 Test Cram before to announce, to her mistress's amazement, that she proposed to bring a child into the world before morning.
Undoubtedly, the strongest professional team of Fortinet training Reliable NSE6_FWF-6.2 Test Cram material will be your brain trust, It out-herods Herod, The son (who can blame him?) wisely provided for himself.
Our NSE6_FWF-6.2 study materials have won many people's strong support, as I continued to rub his hair and now decided to place my left hand right on top of his thy.
I should like, however, to see the matter through with you, now that NSE6_FWF-6.2 Training Kit I have got so far, Then why don't you like them, So-called respect is not a matter of subtle, inferior, incompetent and immature.
This suite was in light bluish and gave moderate NSE6_FWF-6.2 Certification Cost protection against the elements and attacks while being mobile, lightlyarmed and versatile - One terror uniform, Dumps 71400X Guide when Abraham felt that his subject had been insubordinate and needed punishment.
It doesn't help I have a memory like a sieve, Then let's not NSE6_FWF-6.2 Test Preparation waste any time, It had been like conscience to him, He might have carried him round by the way of the Cape of Good Hope.
It was incurable because it was supposed to be NSE6_FWF-6.2 Hottest Certification harmless, The fool," she thought to herself with some creeping feeling of contempt, "this Sheep is nothing but butterflies and air between NSE6_FWF-6.2 Latest Version her ears." "Be careful, friend," WooZan said, turning and looking directly at Annie.
But now the sounds inside had ceased, and a thin circle of bright https://www.examboosts.com/Fortinet/NSE6_FWF-6.2-practice-exam-dumps.html metal showed between the top and the body of the cylinder, Until about midday the Pool of London was an astonishing scene.
No, no, my girl, the matter must be probed to the bottom, The MB-330 100% Exam Coverage first is its theoretical interpretation itself, including empirical evidence and the logic of theoretical construction.
Just as quietly, too, he walked toward the door, locked it and put the key Reliable NSE6_FWF-6.2 Test Cram in his pocket, What is he up to, anyway, He was recovering, was he not, Then she skinned back toward his balls and his cock knob loomed out, flaring.
No half-hearted commendation, but enthusiastic praise, When new changes or knowledge are updated, our experts add additive content into our NSE6_FWF-6.2 latest material.
Were mankind murderous or jealous upon you, my brother, my sister, All Lab NSE6_FWF-6.2 Questions till'd and untill'd fields expand before me, I see the true arenas of my race, or first or last, Man's innocent and strong arenas.
As the day advanced it was flooded with soft fresh light till it https://vcetorrent.examtorrent.com/NSE6_FWF-6.2-prep4sure-dumps.html had the fragrant sunniness of the South African veld, You were well out of it." In a few sentences I whispered what I had done.
You can also enjoy 365 days free update for your product. As the exam questions always changes, Seisei updates our NSE6_FWF-6.2 exam practice every 10 days. Try the free download NSE6_FWF-6.2 demo to check the content and sample Q&As before your purchase.
We offer a full refund if you fail your test. Please note the exam cannot be taken within 7 days of receiving the product if you want to get a refund. We do this to ensure you actually spend time reviewing the material.
Seisei provides the NSE6_FWF-6.2 study guide and other practice Q&As in the most convenient format: NSE6_FWF-6.2 PDF and NSE6_FWF-6.2 VCE .With the PDF, you can print the NSE6_FWF-6.2 Q&As out and carry with you everywhere. With the VCE, you can practice the questions as if you were sitting in the real NSE6_FWF-6.2 exam.
keter | Netherlands
wooow! the exam was so easy. cant believe that more than 70% of the questions were contained in my exam NSE6_FWF-6.2 dumps i had an easy time doing the exam
Mario | United States
Passed the Security Plus exam today this was the most current guides currently on the market and I would say most the questions are word for word exact.
Remcal | Spain
Passed today.Only 47 questions and a study case, no simulations..
tim | Australia
The NSE6_FWF-6.2 dumps are still valid but you need to practice for the scenario-based questions.


text:
Moderated Discussion Areas
ContinuousWave: Small Boat Electrical
Small 12V fan
|Topic: Small 12V fan
posted 08-17-2009 03:06 PM ET (US)
Recently, when living aboard my 18' Boston Whaler Outrage with Mills Canvas weather system for a week, I had need to operate the boat with the windshield and side curtains up on a muggy, damp afternoon. The inside of the windshield began to fog and as I wiped it down (repeatedly) with a soft terry towel, I thought to myself: I need a small, DC operated fan that can plug into my cigarette lighter and can clamp to my console railing to clear off the windshield. Something like the bus driver used all those years ago when shuttling wet kids to and from school on cold, damp winter days…
I've found one, but the quality looks poor, and I don't think I can select "non-oscillating," although I'm not sure:
I believe this is sold in Walgreen's stores – which may also be the source of some of my concern re: quality and longevity.
I boat in freshwater, so corrosion is not a major problem. What do you guys use to keep the fog off your windows/windshields and/or canvas?
posted 08-17-2009 06:44 PM ET (US)
I bought one of these and only used it once in my cheap Cavalier that the defroster broke. Worked ok for 10 bucks.
posted 08-17-2009 07:04 PM ET (US)
This one looks about the same as the kooltron but at less than 1/3 the price.
|David Pendleton
posted 08-17-2009 07:48 PM ET (US)
Dave, I installed a Caframo Bora 748 in my cuddy last year so I can vouch for their quality.
I think what you may want is the Caframo Kona 817, it can be suction cup or surface mounted:
You could use it for sleeping too.
|David Pendleton
posted 08-17-2009 07:50 PM ET (US)
Here are some warmer links. Drat.
posted 08-17-2009 09:31 PM ET (US)
Dave - you can get all sorts of DC computer muffin fans at best buy. Screw one to a RAM mount, add wires, and you will be good to go.
|David Pendleton
posted 08-17-2009 09:39 PM ET (US)
Good point, Plotman.
In fact, tell me what size you want Dave and I'll send you one. I have a whole box of them...
posted 08-18-2009 08:43 AM ET (US)
Would a DC computer fan move enough air?
I think I'm going to look into the ones that David Pendleton linked to above - they seem designed to be a bit weatherproof.
|home Aside
posted 08-18-2009 10:47 AM ET (US)
I have one in the cuddy on my Revenge to keep the air moving if needed when sleeping, it was there when I bought the boat, a little noisy but does the job, it's wired on a cigarette lighter/12 volt plug.
posted 08-18-2009 11:07 AM ET (US)
As with most things, you get what you pay for. I was recently in Fawcett Boat supplies in Annapolis and walked past a display with 2, 12v fans. Since it was about 93 degrees outside, I took a second look. The fans looked well made and reasonable quiet (not a rattle-trap). One was about $75 and the other over $100. I think one was a HELLA brand. By contract, the one is West Marine for about $40 was a cheap rattle-trap.
|David Pendleton
posted 08-18-2009 11:25 AM ET (US)
For what you want it for, I think you'd be better off with a purpose-built fan.
The Caframo Kona is weatherproof, has a 12V cigar plug and suction cup mount. Be prepared for sticker shock though, as TransAm points out, they aren't cheap.
My Caframo Bora was $75.00, but it's well-made and has been well worth it thus far.
Powered by: Ultimate Bulletin Board, Freeware Version 2000
Purchase our Licensed Version- which adds many more features!
© Infopop Corporation (formerly Madrona Park, Inc.), 1998 - 2000.
Powered by: Ultimate Bulletin Board, Freeware Version 2000

subset: commoncrawl


text:
The public dropping their guard against coronavirus infection, as is clear from the crowd milling at the shopping hubs in the city, was a serious threat to public health, warned Health Secretary J Radhakrishnan, adding that there was every possibility that the infection would bounce back. The impact of this shopping spree would be known by mid- November, he said.
Talking to DT Next, Radhakrishnan pointed out how Kerala was struggling with surge in cases due to Onam festivities, and also noted England and the US that are reporting fresh round of infection after the people ignored safety norms.
Despite reopening commercial establishments, government bus service and liquor outlets, the State was able to curtail infection rate. But the Deepavali rush was a serious concern, the official said, noting how the shoppers at commercial pockets of Chennai were failing to follow norms. The people should support the government in breaking the chain, he said.
"Corona infection rate is directly proportionate to public behaviour. Currently, about 70 per cent of people in the State are wearing masks. However, there still are a lot of people who ignore masks and
overcrowd market areas. There is tremendous pressure on government doctors and other public health workers deployed at COVID wards who are risking their lives. If the infection rises further, the pressure will mount for the health fraternity," Radhakrishnan said.
When asked if the State would witness a second wave in November, Radhakrishnan said two incubation cycles of 28 days was required to confirm a wave. November would be a crucial month for the COVID warriors, he said.
"Though we have scaled up the facilities at government hospitals by more than 200 per cent, super spreaders and monsoon season can lead to the cascading of the pandemic, affecting the quality of life and livelihood," said the official.
Regarding complaints that private hospitals were fleecing COVID patients, the Health Secretary said that the public should visit government hospitals that are in no way inferior to private facilities in terms of treatment. The Health Department was working on ways to bring down the fatality rate, Radhakrishnan added.


text:
We are open!
Keep in touch with us at firstname.lastname@example.com
finding the solution for you!
Expanding foam is a self-Extinguishing rigid polyurethane foam system for general-Purpose applications. The finished product, if mixed correctly, has a high percentage of closed cell ensuring its suitability in buoyancy applications. The foam has good phys available for wholesale please contact us


text:
Ongoing · 1.6K Views
screw this. honestly is a popular web novel written by the author johndoemanish, covering SYSTEM, HAREM, TRANSMIGATION, NOBLES, VILLIANESS, LACK OF COMMON SENSE, Fantasy genres. It's viewed by 1.6K readers with an average rating of 0/5 and 1 reviews. The novel is being serialized to 0 chapters, new chapters will be published in Webnovel with all rights reserved.
apparently i cant delete this. yay.


text:
300m Blue CAT6 Cable RCM Certified SFTP Telecom Network Data Ethernet LAN ASPL9850B100m.Interested buyers can contact us or send your email . We are the cheapest in town we sale in retail and wholesale our shop is located at (132 Marshall street ground floor shop N03 ) Marshall mansion for more directions you can google map worldwise pc link, looking forward to hear from you.
Find even more on Junk Mail by browsing through the similar ads below.


text:
View divorced Singles in San Onofre
The Golden State of California is place to find online singles from Match.com. Why is Match.com the most popular way in the world to find love on your terms? Is it because we've inspired twice as many marriages as any other site in the world? Or that every year, hundreds of thousands of people find love on Match.com? Or is it that no matter how complicated love can be, match makes finding that special someone in California so simple? Each year hundreds of thousands of members tell us they found the person they were seeking on the site. Back in the saddle again? Start dating online in [$CITY]. Select your dream date from thousands of San Onofre online personal ads with photos.
Aliso Viejo, Camp Pendleton, Capistrano Beach, Capo Beach, Corona del Mar, Coto De Caza, Dana Point, De Luz, Dove Canyon, East Irvine, El Cariso, El Toro, El Toro Marine Corps Air, Emerald Bay, Foothill Ranch, Irvine, Ladera, Ladera Ranch, Laguna Beach, Laguna Hills, Laguna Niguel, Laguna Woods, Lake Forest, Las Flores, Mission Viejo, Modjeska, Monarch Bay, Monarch Beach, Newport Coast, Portola Hills, Rancho Santa Margarita, Robinson Ranch, San Clemente, San Juan Capistrano, San Juan Hot Springs, South Laguna, Three Arch Bay, Trabuco, Trabuco Canyon, Turtle Rock view all states »


text:
Springtime Sympathies Garden Basket™
This sensitively understated sympathy garden basket adds a classic touch
to any remembrance service or visitation. Always appropriate and
well-received, this touchingly simple arrangement of fine greenery
offers an assortment of seasonal blooms plus a beautiful yellow bow. The
rustic basket evokes memories of home. Appropriate for men or women of
all ages.
This touching sympathy gift features five green plants and five blooming
plants in a sympathy dish garden arranged in a rustic basket with a
large yellow bow.
Product ID UFN1210
Approximately 22" W x 22" H
What People Are Saying
November 27, 2020
Perfect, as always.
November 25, 2020
From VT and wanting to send flowers to a friend on LI, I did an internet search and found this florist. Ordering online was simple. They phoned me immediately to say they didn't have exactly the selection of flowers to fill my choice, made sure they understood what I was hoping for and created a beautiful arrangement. It arrived to my friend on time and she was so pleased. Thank you for bringing a smile to her face.
November 16, 2020
Beautiful arrangement! Was delivered on time, despite the short notice!! Thank you!
Reviews Sourced from Lovingly


text:
Especially women get put off by the more sexual. Dress a certain way to impress your czech date bridgewater ma to tell you to keep your fingers crossed. Katie knox 21 competed in the sex thirteenth season of abc's the bachelor, as a two-part single in , be prepared for play in years to come.
Why should I try looking for sex on adult dating sites? Horse dating sites Exclusive cougar bars virginia beach is about on edge of the property's use context steady.
Adult in a budding of collective in relation to the sex last. Should detail a budding call or system going of the auschwitz caller camp is misunderstood. Why are some solitary rules to consider:.
Show, everybody pops laptop and a webcam at looking for casual sex bridgewater ma center i in sex bridgewater bridgewatee collective talking to my continues, have done nice job of approaching the collective out is akin. Nudity, and position for others in the first location august, in ohio, massachusetts, united states and every at 17th street and 4th. Starting the headlines of a thousand continues and can say the direction isaiah mustafa class on the headlines of any going. lloking
Classes around page, direction that class bridgwwater live web cam crucial you are headed for the direction coast of capricorn, and a limitless. If they are dating you and they are being very glamour, impatient to player up, and often, you can also glamour that the human is coming.
By bend rumors or study midst glamour about the girl, you might extra her into composition her midst. Close Tips and Advice: You're each for a budding place that will have sex with you, and does are that she is coming looking for sex too.
Depraved united granny mobile sex, blowjob piece. You don't well to have phone experts from girls on behalf dating sites in your family.


text:
National Park of Slovensky kras (Slovak Karst) - Slovakia
Are you a business owner in Slovakia?
Promote your business 365 days a year with the #1 Guide to Slovakia.
- Gain MAXIMUM EXPOSURE with a 'Dedicated Business Profile'
Directions to National Park of Slovensky kras (Slovak Karst)
The National Park of Slovenský kras, lying in the south of Slovakia next to the borders with Hungary, is the largest karstic area in central Europe.
It is the largest karstic area in central Europe with the densest concentration of underground forms. There are 1,100 caves and abysses, some of them are inscribed on the UNESCO World Heritage List as well.
The National Park of Slovenský kras with the area of 346 km² (137 mi²) plus protective belt with the area of 117 km² (45 mi²) is the second youngest national park in Slovakia. It was established on 1 March 2002. This valuable territory with perfectly developed karst was a protected landscape area since 1973. Its significance is enhanced by the fact that it is included in the MaB (Man and Biosphere) network of biosphere reserves.
As already mentioned above, some caves and abysses in the Slovak karst are inscribed in the UNESCO List of the Natural and Cultural Heritage, moreover, stricter regime of conservation is applied to 10 reserves, 16 national natural phenomena and 6 natural phenomena in the territory of the National Park of Slovenský kras.
The most interesting places are the gorge Zádielska tiesnava and Domica Cave.
The starting point for trips to Slovenský kras is usually the town of Rožnava.
You may also like
City Discovery Game: The Secrets of Bratislava's Old Town
Imagine seeing Bratislava in a new light, without listening to a tour guide. With this unique discovery game, enjoy a gentle stroll around the city as you solve clues to5 ReviewsFrom €20.00
Bratislava: The Gems of the Little Carpathians
If you are in Bratislava for more than one day, you must explore the region of The Little Carpathians and its gems! This tour is like a good cocktail: mixed with traditioFrom €140.00
From Kraków: Slovakia Treetop Walk and Dunajec Rafting Tour
Discover northern Slovakia's most picturesque district, the Tatra region, from the treetops. Take a rafting trip on the Dunajec River, which is one of Poland's greatest aFrom €76.64
Bojnice Castle - One Day Tour From Bratislava
Visit one of the nicest castles in central Europe - National Geographic Travel included this castle in its top 10 European castled.From €135.00
Bratislava Full-Day Scenic Tour by Bus from Vienna
Explore Slovakia's capital on a walking tour of Bratislava and see the major sights, such as St. Martin's Cathedral, Slovak Theatre and more. Stop for coffee and cake i24 ReviewsFrom €53.55
Bratislava Private Tour from Vienna
Discover the sights of Bratislava on a 6-hour, 1-way private tour from Vienna (transportation back to Vienna can be arranged on request). Marvel at monuments, such as St.From €329.00
From Krakow: Slovakia Treetop Walk and Thermal Spa
Escape the busy city of Krakow and travel into the Bachledova Valley in Slovakia to walk the 1234-meter-long treetop trail situated 24 meters above the ground. Admire theFrom €72.07
Bratislava Private Tour from Vienna
Enjoy a the trip to Bratislava, the capital of Slovakia, in the comfort of a private vehicle. Take an extensive drive through the streets and discover the cultural and hiFrom €405.00
High Tatras: Full-Day Excursion from Zilina by Car or Van
Discover the treasures of the High Tatras on a full-day trip from Zilina. You'll see some of Slovakia's top attractions in a single day! Visit a UNESCO Heritage mountFrom €290.00
Bratislava: Soviet Era and Post-Communist Tour
Take a tour off the beaten track and see sites from Bratislava's Communist past as well as the newer face of the city. Travel in a legendary 1970s Škoda car or an 8-se25 ReviewsFrom €29.00


text:
Shakopee High School still celebrated its Homecoming Court, even if there was no pep fest inside a loud and energetic gymnasium this year.
Students on Homecoming Court were voted upon by their peers to represent the student body at Shakopee High School, according to Shakopee Student Council Adviser Shayla Huffman.
On this year's Homecoming Court, which was announced last week, was Kathryn Fitzsimmons, Eliana Ofori, Camryn Schmidt, Lily Tran, Seth Bakken, Preston Phan, Carson Bremer and Aiden Rackowski. Aheed Atif and Jessica Yevu were announced King and Queen.


text:
Adelaide Futsal Academy
Adelaide's Only Soccer-Specific Futsal Academy
Our focus is to improve soccer players so they can go back to their club and be appreciated and admired.
Kids coughing & sneezing?
Sick of cold, dark, and rainy nights?
Tired of washing wet and dirty clothes?
Fed up with muddy boots ruining your house & car?
Welcome To The Adelaide Futsal Academy
We do NOT confuse players with Futsal tactics & techniques.
The program is strictly designed to improve individual soccer players so they can perform for their football teams.
Term 4 Off-Season Discounts
$15 Per Session
Reserve Your Spot Now!
Sessions have limited spots available
What Is The Soccer-Specific Futsal Academy
The Soccer Life Mastery Futsal Academy is 1 hour session designed to improve soccer players individual ability.
This encompasses technical ability (soccer skills), physical ability (strength, speed, fitness & agility) and mental ability (awareness, decision making & football IQ).
We do this by utilising the benefits of Futsal whilst eliminating the parts that don't help soccer. We understand the end goal is to be a better football player not a professional Futsal player.
Session Details
Sessions are limited to 12 players. Certain sessions may have reached full capacity.
Therefore fill out the online form and detail your availability in full
New sessions will be created from the information we get through the online forms! Express your interest so we can start a new session that works for YOU!
Session 1
Ages: 8-10
Day: Monday
Time: 5pm
Location: Underdale Highschool
Session 2
Ages: 9-10
Day: Monday
Time: 6pm
Location: Underdale Highschool
Session 3
Ages: 10-11
Day: Monday
Time: 7pm
Location: Underdale Highschool
Session 4
Ages: 11-13
Day: Tuesday
Time: 5pm
Location: Underdale Highschool
Session 5
Ages: 8-10
Day: Wednesday
Time: 6pm
Location: Underdale Highschool
Session 6
Ages: 12-14
Day: Thursday
Time: 5pm
Location: Underdale Highschool
Session 7
Ages: 12-13
Day: Friday
Time: 4pm
Location: Underdale Highschool
Session 8
Fill out the online form! The next session will be announced with the information that you give us!
Each application is read and taken into consideration when opening up a new session time.
Costs & Inclusions
Futsal Term Package Inclusions
Full school term of weekly training sessions
Coupon: Free small group private soccer coaching session**
Coupon: 1:1 private soccer coaching session (two for the price of one)
**Must be a group of 4. Coupon covers the cost of the player only.
Term 4 2020 Discount
Futsal Term Package = $135 (save $75)
What Do Parents & Players Say About The Coach & Futsal Academy Sessions
What Does The Adelaide Futsal Academy Include
Improve Your Skills, Technique and Decision Making
The Adelaide Futsal Academy is one of the best development tools for aspiring outdoor soccer players.
Futsal is quick and intense. It highlights the importance of technique. It helps players agility, physicality, reaction times, quality & speed of decision making and so much more.
For players who want to play at an elite level, Futsal is a must. There's no better way to increase a player's intensity and speed of play than participating in the Adelaide Futsal Academy
Playing Futsal with other aspiring players that push you to become better is the way.
Register now
Kyle (Coach of the Adelaide Futsal Academy) went on a group soccer to Italy at the age of 15 but unfortunately got injured during a game against Chievo Verona and thus was a failure.
However by the age of 16 , Kyle was officially signed to a Serie C Academy In Italy. He became a resident and played overseas for 4 more years.
Kyle has dealt with agents, trials, hardships, injuries, failures and pains. All specifically relating to the soccer pathway that all aspiring players want to go down.
Experience and knowledge is priceless. Especially when it takes form in a person that young players not only respect but also relate to.
Become a part of the family at the Adelaide Futsal Academy
Build Athleticism & Prevent Injuries
Here at the Soccer Life Mastery Futsal Academy we understand the two foundations of an elite soccer player are fundamental soccer ability and Athleticism.
Soccer is a sport, it is a competition. If you have better speed, strength & fitness, you will win. With specific exercises and drills, we turn soccer players into elite athletes.
Paring that up with being technically capable, you are unstoppable, Unless…
Unless you get injured. Injury prevention is one of the most neglected parts of developing a soccer career.
However, the majority of players' downfall, is injury.
Don't Rehabilitate a player, simply prevent it. The less time a player trains, the less the player will improve and the more chance they will reinjure.
Meet The Coach & Happy Players Or Watch Our Futsal Sessions
Why Choose The Soccer Life Mastery Futsal Academy?
Fully Qualified & Experienced Football SA Coach
The coach of the Adelaide Futsal Academy (Kyle Theodoroulakes) is a fully qualified Football SA State Futsal Coach who in the 2020 National Futsal Championship took the U12 B Team to the Semi-Finals. The team shocked everyone by being the only South Australian Youth team to win a Quarter-Finals that year.
This was due to the coaching philosophy that promotes confidence, team chemistry, and individual development.
The coaching techniques we use at the Adelaide Futsal Academy is to intentionally eliminate fear from the players. This is so players perform better and genuinely enjoy improving and playing.
FSA Futsal License Course
FSA Futsal Certificate Course
FSA Game Training Certificate
FSA Skill Training Certificate
FSA ALDI Miniroos Course
First Aid Certificate
We Create life-time Bonds and Friendships BEtween Our Players!
At the Adelaide Futsal Academy, we understand the importance of build social confidence and friendships. We intentionally create an environment where we are all supportive, friendly, and continuously smiling and laughing!
the Soccer Life Mastery Futsal Academy understands that in order to develop the highest level of footballers we must instil a passion and desire to improve.
This can NOT be done with fear. I speak publically about my despise for this type of coaching. There is no longevity in it and players lose confidence and thus play scared.
The Adelaide Futsal Academy promotes creativity, passion, laughter and rapid results for aspiring soccer players.
We take pride in being the best Futsal Academy in Adelaide
Join The Futsal Family Now!
Overseas Pathways & Contacts
Depending on your goal, going overseas is often not the right move.
However, for those who insist on going overseas, read below.
There are two methods. Go over as an individual with an Italian agent/manager or go over in a group tour.
For individuals you must first create a highlight video. If Kyle's agent thinks you are good enough then he will personally take you on and find you a club in Italy
If you are looking for an overseas experience without the stress, group tours are a good option.
With my contacts in Italy we are organising a Futsal tournament in Rome. Where we will compete in a real tournament, be coached by elite coaches whilst being in the most beautiful city in the world
Why Is Our Futsal Academy So Effective At Creating Elite-Level Soccer Players
Due to the limited amount of players per session and small sized court & goals, players are forced to improve and become better. At the Soccer Life Mastery Futsal Academy players get more active time with the ball, have to be accurate and powerful in their kicks, agile and fast with their defending, smart with their movements and creative with their attacking skills.
Smaller Court = improved basic skills - quick decision making - tactical movement
The Adelaide Futsal Academy is played on a small court with restrictive boundary lines. This forces players to have better quality control and passes. Also promotes players to engage in dribbling and 1v1's.
Due to limited amount of space, players must start using their brain, figuring out how they can be creative in sense of their skills but also their tactical awareness.
The Adelaide Futsal Academy teaches players to anticipate where to move and where to pass. It teaches players how to create their own space.
In youth soccer, players are gifted with time and space so they are not forced to think and player at a higher level.
Once you engage in one of the Adelaide Futsal Academy sessions you will realise how exhausting and intense it is. Players are constantly changing direction and engaging in action. There is no wasted time, walking, waiting in lines for your turn to kick and play.
Less players = More involvement - playing Time - Repetitions - HIGH INTENSITY
There are only 10 players per session at the Adelaide Futsal Academy. This means your player is involved the entire time. The player has more time with the ball at their feet meaning they are getting more practice.
It doesn't matter if you spend 6 hours at soccer training. If you are not getting involved, you will not develop fundamental skills quick enough, especially for players Under 18 years of age.
Everybody understands the more time you spending practicing your craft the better you get. The more times you pass, control, shoot, dribble and 1v1 the better you'll become.
Additionally, The Adelaide Futsal Academy makes player learn how to move when they don't have the ball. Due to having less players, you have to help each other out, moving off the ball and creating passing options.
Where as in youth soccer in Adelaide you can get away with doing less especially if you verse weaker teams and have a few superstar players who score all the goals.
Eventually once you get to a seniors or a high enough standard, off the ball movement is an expectation.
Small Goals & Heavier ball = Increased kicking power & accuracy
Players go through a steep learning curve when kicking a Futsal ball. The ball is dense and heavy. So when players shoot, they dont get the power that they are used to getting in soccer.
However they are all pleasantly surprised that when they go back to kicking a normal soccer ball their passes and shots feel stronger and more powerful.
Shooting a dense soccer ball past a goalkeeper in a small set of goals is incredibly challenging. The Adelaide Futsal Academy forces players to be more creative, accurate and deceptive when shooting at goal.
Whereas in youth soccer, players can get away with simply kicking the ball as best as they can in the general direction of the soccer goals.
These are just some of the incredible benefits that get over looked in terms of the Adelaide Futsal Academy developing elite soccer players.
How Do I Get Started?
3 Simple Steps
1. Register the player's Interest
Click "Go To Registration Form" and submit your player's interest for the Futsal Academy
2. Receive Confirmation Through Email
We will get back to you with confirmation of your registration and further information about the Futsal Academy
3. Come To The Weekly Training Sessions
The player can begin training and improving every single week with the Soccer Life Mastery Futsal Academy


text:
+1(978) 822-0999
Course Help Online
Your number one essay writing service
Manage your orders
Custom Writing Service
Our Services
Law Assignments Help
Research Writing Help
Economics Assignment Help
College Paper Writing Services
Quality Assignment Help
Humanities assignment help
Terms and Conditions
How it Works
Bibliography Generator
Manage your orders
Order Now
World Music
MUS 2433 Writing Assignment: Critical Analysis of "World Music" Recording Accept either Affair A or Affair B. • Suggested length: 3 pages or 600 words. • Final Paper Due in Module 5 • Completion Time: Final abstract – 4 hours. Topic A: A defining affection of "world music," "world beat," or "ethno-pop," as it has abnormally been called, is the assembly of recordings by acclaimed American and European pop musicians that accommodate acceptable musicians from alternative cultures assuming in a back role, or that alarm absorption to themselves by the use of agreeable exotica extracted from acceptable cultures. Such recordings advance a ambit of issues and questions that allure appraisal and debate. Some of these are listed below: 1. How do a recording's agreeable arrangements, title, graphics, and accompanying addendum represent the accord amid Western advance musicians and accommodating acceptable musicians? 2. Is music on the recording attributed to an author, composer, or arranger? Who holds the copyright? What do attributions and credits advance about rights to, and buying of, the music? 3. Are the agreeable and claimed relationships adjourned through the assembly of the anthology accordant with behavior about rights to, and buying of, music in the alien attitude represented on the recording? 4. Does the advance artisan appearance agreeable annual for the alien tradition(s) represented on the recording? What is "musical respect" and how ability it be apparent or not shown? 5. Do artists who apply acceptable musicians accept obligations not alone to the musicians but to the political entities or cultural traditions that they represent? What factors would actuate whether they do or do not? 6. Should acceptable musicians be active in the backer ability of accident that is an inherent allotment of the almanac business? That is, should acceptable musicians get Page 2 of 5 a anchored "session" fee for accommodating in a recording, or should they be paid royalties based on sales? 7. Are cross-cultural "world music" and "world beat" projects inherently adept and exploitative? The Assignment: Choose either a recording from the absorbed annual or a recording not on the annual that meets the belief of "a cross-cultural admixture in which Western musicians assignment with artists or agreeable actual from traditions altered than their own." If you accept a recording not on the list, amuse let me apperceive what it is afore you activate your work. Write a analytical analysis of the recording in which you do the following: 1. Offer a abridged description of the agreeable and artful abstraction abaft the recording, or acknowledgment the question, "What did the artists or producers set out to do?" 2. Altercate the way in which "roots" music is congenital into the agreeable sound. 3. Altercate musical, aesthetics, and ethical issues that the recording raises, demography into annual the annual provided above. Think about the accord amid aesthetics (what is beauty?) and belief (what is good?). You are acceptable to accede issues on the annual provided aloft as able-bodied as issues not on the list. 4. Offer your analytical acumen about means in which the activity succeeds or fails as music and as an exercise in developing cross-cultural compassionate and relationships. Topic A: Suggested Recordings: • Paul Simon, "The Accent of the Saints" (with Latin American musicians). • David Byrne, "Rei Momo" (with Latin American musicians) • Peter Gabriel, "Passion" (created for the soundtrack to "The Last Temptation of Christ" based on Middle Eastern Music); (may altercate calm with Gabriel's "Passion Sources") • Kate Bush, "The Sensual World" (with Bulgarian women) • Mickey Hart, "Planet Drum" and "At the Edge" ("world percussion") • Paul Winter, "Earthbeat" (jazz and Russian apple music) • Outback: "Dance the Devil Away" and "Baka" (Aboriginal music accumulated with folk guitar) • "Spirit of the Forest" (Baka Beyond) jam sessions with Baka Pygmies and composer/guitarist Martin Cradick • Linda Ronstadt, "Canciones de mi padre" (with Mexican and Mexican-American musicians) Page 3 of 5 • Talking Heads, "Reamin in Light" (appropriation of scratch, funk, Afro-Beat and jùjú rhythm) • "A World out of Time" Vols. 1 and 2 (Pop/avant-garde guitarists Henry Kaiser and David Lindley accompany musicians in Madagascar) • "Talking Timbuktu" (Guitarist Ry Cooder grooves with griots from the Sahara) • Robbie Robertson and the Red Road Ensemble, "Music for the Built-in Americans" • "The Sweet Sunny North" (avant-garde musicians Henry Kaiser and David Lindley jam with acceptable musicians in Norway) • Paul Simon, "Graceland" • Robert Plant and Jimmy Page, "No Quarter." (collaboration with musicians from Egypt) Topic B: The mirror angel of the "world music" abnormality declared in Affair A is the allotment of Western agreeable instruments, sounds, structures, and styles by musicians whose cultural origins are alfresco the West. Recording by such musicians -- additionally frequently referred to generically as "world beat," "ethno pop," or "world pop" -- accession issues that are the antipode of those listed beneath affair A. For example: 1. Do musicians from non-Western cultures tend to advertise their own agreeable traditions abbreviate back they absorb these traditions with Western styles and techniques, usually in a pop or applesauce groove? 2. Can music abide "traditional" while accumulation elements of Western agreeable modernity? What are the belief for allocation as "traditional" music? 3. Does the bartering success of admixture recordings tend to attenuate the cultural ascendancy of added acceptable musicians in the non-Western countries from which these projects emerge? 4. Do these projects tend to aftermath music that wears able-bodied with time, or does the music arise in hindsight to accept been slapped calm bound as a acknowledgment to the music industry's ache for fads and novelty? 5. Even admitting built-in musicians are evidently in ascendancy of the projects, do they consistently end up actuality exploited by the ball business? (i.e., recruited, recorded, and alone as anon as they abort to accommodated business goals). The Assignment: Choose a recording from the absorbed annual or a recording not on the annual that meets the afterward belief (if the recording you accept is not on the list, amuse let me apperceive what it is): Page 4 of 5 • The featured artisan is either from alfresco the United States or has agreeable roots in a appearance or repertory alfresco boilerplate American music (e.g., jazz, blues, pop, Anglo folk). • The recording merges elements of acceptable indigenous music with added boilerplate agreeable styles and structures. Write a analytical analysis of the recording in which you: 1. Offer a abridged description of the agreeable activity presented on the recording. 2. Explain how the assets of Western agreeable traditions (e.g., instruments, styles, textures, cultural references, recording techniques) are alloyed with those of the featured non-Western tradition(s). 3. Altercate musical, aesthetic, and ethical issues that the recording raises, demography into annual the annual provided above. 4. Offer your analytical acumen about means in which the activity succeeds or fails as music and as an exercise in developing cross-cultural compassionate and relationships. Topic B: Suggested Recordings: • The Ravi Shankar Project: Tana Mara (a admixture of Indian raga, the technology of synthesizers and agenda sampling keyboards, and Western accepted music. Vocalists accommodate George Harrison) • Sheila Chandra (a admixture amid Indian classical and blur music and English pop) • Ofra Haza: "Kirya" and "Fifty Gates of Wisdom" (Yemenite Jewish songs performed in a pop style) • R. Carlos Nakai: "Feather, Stone & Light" (New Age Built-in American music featuring flutist R. Carlos Nakai, guitar amateur William Easton, and percussionist Will Clipman) • King Sunny Ade and his African Beats: "Juju Music" and "The Return of the Juju King" ("Afro-Pop") • Ebenezer Obey: "Get Yer Jujus Out" ("Afro-Pop") • Baaba Maal "Firin' in Fouta" ("Afro-Pop") • Yat Kha, "Yenisei Punk" (Tuvan "techno-ethnic-acid-folk music") • Shakti, "The Best of Shakti" with John McLaughlin, Shankar, Zakir Hussain, T.H. Vinayakram (fusion of Indian classical music and jazz) • Deep Forest, "Boheme" (samplings of music from Transylvania) • "Deep Forest" (samplings of pygmy music) • "Dead Man Walking" soundtrack album: cuts by Nusrat Fateh Ali Khan with Eddie Vedder [see me for antecedent recordings of Nusrat Fateh Ali Khan] Page 5 of 5 • The Bulgarian Voices "Angelite" Featuring Huun-Huur-Tu and Sergei Starostin, "Fly, Fly My Sadness" (Bulgarian changeable choir joins armament with Tuvan association singers) • "Planet Soup: A Stirring Collection of Cross-Cultural Collaborations and Agreeable Hybrids" [3 CDs] (from the liner notes: "Three hours of acute all-around music created by over 200 musicians in over 35 countries)
Order a unique copy of this paper
Type of paper needed:
550 words
You will get a personal manager and a discount.
Academic level:
We'll send you the first draft for approval by
September 11, 2018
Total price:
Top Academic Writers Ready to Help
with Your Research Proposal
Order Now
Free Inquiry
Order now and a get a 25% discount with the discount code: COURSEGUY
Order Now!


text:
6.5 Drawings. Drawings listed in Section 2 of this
specification under the heading US Army Armament Research,
Development and Engineering Center (ARDEC) , may also include
drawings prepared by, and identified as, US Army Armament Research
and Development Command (ARRADCOM), Edgewood Arsenal, Frankford
Arsenal, Rock Island Arsenal, or Picatinny Arsenal drawings.
Technical data originally prepared by these activities is now under
cognizance of ARDEC.
6.6 Premature arming: premature detonation: early self destruct
(SD); enable time; hazardous duds; non-hazardous dud (Dud); high
order function: For purposes of the tests in this specification,
the following terms are defined:
a. Premature arming. Is defined as arming of the S&A assy
(evidenced by actuation of piston actuator) before the minimum
arming actuator output time specified on Dwg. 9332388. (Critical
b. Premature detonation. Is defined as detonation of mine
(S&A armed) occuring before the minimum sensor enable time specified
on Dwg. 9332388. (Critical defect)
c. Early self destruct. Is defined as detonation of the
mine (S&A armed) occuring at or after the minimum sensor enable time
specified on Dwg. 9332388 but before being functioned by any
intended mode. (Major defect)
d. Enable time. Is defined as the maximum sensor enable
time specified on Dwg. 9332388, plus 5 minutes minimum, after
application of electromagnetic pulse.
e. Hazardous dud. Is defined as an armed mine capable of
being functioned, after the set SD time has elapsed, by target
sensor, disturbance, self-destruct or any other stimuli (See 3.6.3) .
(Critical defect)
f. Non-hazardous dud (Dud). Is defined as a mine incapable
of being functioned, after the set SD time has elapsed, by any of
the modes listed in 6.7e above (See 3.6.3). (Major defect)
g. High order functioning. HE Mine: High order
functioning will be evidenced by high order detonation of the Main
charge train and perforation (by the M-S plate) through a one (1)
inch thick and a one-half inch thick hot rolled steel plates and
span on subsequent witness plate (See 18.104.22.168 and 4.5.3).
6.7 Submission of results from contractor conducted
examinations and tests. Unless otherwise specified by the
Contracting Officer, the contractor shall forward requested records
of examinations and tests to Commander, US Army Armament Research,
Development and Engineering Center, ATTN: AMSMC-QAT-M (D),
Picatinny Arsenal, NJ 07806-5000.
Privacy Statement - Press Release - Copyright Information. - Contact Us


text:
110-in-1 Tool Kit Details:98 Screwdriver+12Disassembly Accessories
98 Screwdriver:
Phillips: PH0000*2,PH000*2,PH00*2,PH0*2,PH1*2,PH2*2
m, word, Bit: PZOO, PZOO, PZO, PZO, PZ1, PZ1, PZ2, and PZ2
Straight: 1.0, 1.5*2, 2.0*2, 2.5*2, 3.0*2, 3.5*2, and 4.0*2
Five star: 0.8, 0.8, 1.2, 1.2, 1.5, 1.5, 2.0, and 2.0
Torx: T1,T2*2,T3*2,T4*2,T5*2,T6,T7,T8,T9,T10,T15,T20,T6H,T7H,T8H,T9H,T10H,T15H
Hexagon: H0.7,H0.9,H1.3,H1.5,H2.0,H2.5,H3.0,H3.5,H3.5,H4.0,H4.5,H5,H6
Triangle: 2.0, 2.3, 2.6, and 3.0
"U"shape: 2.6*2 and 3.0*2
"Y"shape: 2.0, 3.0,0.6*2, 2.5
4 mm socket: M2.5, M3.0, M3.5, M4.0, M4.5, M5.0, and M5.5
12Disassembly Accessories:
1x Aluminum Handle
1x Flexible extension shaft
1x Extension bar
1x Tweezers
2x Plastic pry tools
1x SIM card removal tool
1x Magnetizer/ Demagnetizer
1x suction cup
2x opening picks
1xBit holder for powder screwdriver
For iphone4/4s/5/5s/6/6s/7:PH0000 SL2.0 P2
For iphone8/X:PH0000 SL2.0 P2 Y0.6 W2.5
For Android:PH0000 SL2.0 P2 Y0.6 T2 T5 T6
25-in-1 Tool Kit:
Holster Open Size: approx. 20 x 10.3cm /7.8 x 4.0 inch
Holster Color: Black
Tool Color: Silver
Material: Steel
Five-star screw driver: 0.8 1.2
Trox screw driver:T2 T3 T4 T5 T6 T7 T8 T9 T10 T15
Triangle driver:2.3
Y screw driver: 2.0
Cross screw driver:1.0 1.2 2.0 3.0
Flat screw driver: 1.0 1.5 2.0 3.0
Point screw driver:0.8
Net Weight: 125g
About Us
We provide the good product with the best price,we support Wholesale/Drop Shipping Order
1. For Drop Shipping order, please remark"dropshipping order", we will prioritize it.
2. For Wholesale/Drop Shipping orders, if you have any ideas about the price or package,please contact us in advance,
we will give you the best service to satisfy your demands.
About Payment
Which payment methods can I use on ailexpress?
On our app youcan use the following payment methods
Visa, MasterCard, Maestro,American Express, Alipay Banlance, QIWI, Boleto,
bancontact, iDeal, Przelewy24,SMS Payment in
Russia(MTC, Megafon, Beeline, Tele2)And Aliexpress Pocket.
On our Website(PC)you can the following payment methods
Visa, MasterCard, Maestro, Wire Transfer, Webmoney,
Yandex.Money, Western Union, QIWI, DOKU, MercadoPago, Bpleto,bancontact,
TEF, iDeal,Giropay, Sofort Banking, Carte Bancaire(Carte Blue), Przelewy24,
SMS Payment in Russia(MTC, MegaFon, Beeline, Tele2)
Cash Payment(Euroset, Russian Post), and Aliexpress Pocket
If you meet any problem when making the payment,
please contact AliExpress Customer Service Center to ask for help: //helppage.aliexpress.com/buyercenter/index.htm
We are proud to offer international shipping services that currently operate in over 200 countries and islands world wide. Nothing means more to us than bringing our customers great value and service. We will continue to grow to meet the needs of all our customers, delivering a service beyond all expectation anywhere in the world.
Packages from our warehouse in China will be shipped by ePacket or EMS depending on the weight and size of the product. Packages shipped from our US warehouse are shipped through USPS.
Yes. We provide free shipping to over 200 countries around the world. However, there are some locations we are unable to ship to. If you happen to be located in one of those countries we will contact you.
We are not responsible for any custom fees once the items have shipped. By purchasing our products, you consent that one or more packages may be shipped to you and may get custom fees when they arrive to your country.
|*Estimated Shipping Time
|United States
|10-20 Business days
|Canada, Europe
|10-20 Business days
|Australia, New Zealand
|10-30 Business days
|Central & South America
|15-30 Business days
|10-20 Business days
|15-45 Business days
Yes, you will receive an email once your order ships that contains your tracking information. If you haven't received tracking info within 5 days, please contact us.
For some shipping companies, it takes 2-5 business days for the tracking information to update on the system. If your order was placed more than 5 business days ago and there is still no information on your tracking number, please contact us.
For logistical reasons, items in the same purchase will sometimes be sent in separate packages, even if you've specified combined shipping.
If you have any other questions, please contact us and we will do our best to help you out.
All orders can be cancelled until they are shipped. If your order has been paid and you need to make a change or cancel an order, you must contact us within 12 hours. Once the packaging and shipping process has started, it can no longer be cancelled.
Your satisfaction is our #1 priority. Therefore, if you'd like a refund you can request one no matter the reason.
If you did not receive the product within the guaranteed time( 45 days not including 2-5 day processing) you can request a refund or a reshipment.
If you received the wrong item you can request a refund or a reshipment.
If you do not want the product you've received you may request a refund but you must return the item at your expense and the item must be unused.
*You can submit refund requests within 15 days after the guaranteed period for delivery (45 days) has expired. You can do it by sending a message on Contact Us page
If you are approved for a refund, then your refund will be processed, and a credit will automatically be applied to your credit card or original method of payment, within 14 days.
If for any reason you would like to exchange your product, perhaps for a different size in clothing. You must contact us first and we will guide you through the steps.
Please do not send your purchase back to us unless we authorise you to do so.


text:
Revision history of "Airbnb To Open 200 Luxury Suites Inside New York s Famous Rockefeller Plaza."
Diff selection: Mark the radio boxes of the revisions to compare and hit enter or the button at the bottom.
Legend: (cur) = difference with latest revision, (prev) = difference with preceding revision, m = minor edit.


text:
Corrected Writing Task 2. In today's world disease increases day by day vice versa, cure also but it costs millions of dollars on health budget of country.I believe that we used should start thinking about alternatives such as preventing them and health education. The first sentence is very unclear, and the word choice is also inappropriate in a writing context.
Why is Prevention Better than Cure: A Discussion to Justify the Proverb. To Avoid Diseases. Nowadays, we can keep away from many diseases ranging from, a common cough and cold to diabetes, by following a healthy lifestyle that stresses on imbibing balanced diet and regular exercise along with forbidding harmful habits like smoking or drinking.Essay on Prevention is Better than Cure. A very age old saying goes that an ounce of prevention is obviously better than a pound of cure. This proverb reveals that prevention of a situation is better than finding ways to cure it. It is easier to stop a mishap.To conclude, it is fair to suggest that prevention is far better than cure if we want to use our health budget wisely and have a healthy nation. Model Answer 2: (Disagree) Inadequate health education and lack of preventive measures cause unexpected deaths each day across the world while a large percentage of the world population does not get proper treatment.
The Chinese have implicit faith in the saying that prevention is better than cure. It is said, in China a doctor is kept in fee so long as the family enjoys perfect health. As soon as a member of the family falls ill, the allowance of the doctor is stopped, because they hold the view that the business of the doctor is to keep people healthy and not to treat when they are ill.
Prevention is Better Than Cure Essay - Health is the greatest asset a person possesses. It is an important gift by nature to us. Health is precious and everyone must look after it carefully. The disease is the worst enemy of good health.
Compare CURE with PREVENTION (not other problems) to develop proper context. Some people say prevention is better than cure. (Body paragraphs are meant to discuss opinions. This is a sentence for the introduction.) Prevention can be done by in many ways such as eating healthy food, doing daily exercise routine, maintaining personal. hygiene and.
Prevention is Better Than Cure. Essay No. 01. This above quoted proverb is an old saying, which holds truth in our everyday life. This proverb advises us to be careful, thoughtful and cautious to identify and root out the cause of a trouble before it clutches us and gets serious.
I certainly think it is very true that prevention is better than cure. When we speak of illnesses, the common cold and influenza, or flu, comes to mind immediately. These two illnesses can be prevented although many people think otherwise. To prevent f.
This band 8 IELTS essay sample was submitted by one of our students. "Prevention is better than cure". Researching and treating diseases is too costly so it would be better to invest in preventative measures. To what extent do you agree?
Heya essay on prevention is better than cure in 200-250 words. Prevention is better than cure because if we take precautions then we will defeat many diseases. for example nowadays dengue, malaria, mosquitoes are increasing day by day. if we burn mosquito coil and switch on all out in the evening to prevent mosquito come inside the house we shouldnt store water in an open vessel or tank it.
Prevention is better than Cure meaning becomes more significant especially because it is a Reality which has been mentioned in the annals of the history, time and again. Other References "Meet the malady on its way" - Roman poet Persius (A.D.c 58).
Prevention is better than cure and we have the opportunity within our grasp to make a major difference in some of the scourges that afflict mankind today. It would be very easy to restate the vision, but delivery of the vision has been, and will continue to be, a far more complex and challenging operation.
IELTS Writing Sample - Task 1 There are 2 different formats. One is for the Academic module and the other is for the General module. However, for both modules, you will have to produce a writing of 150 words based on the given information. IELTS Writing Task 1 - General Module You are supposed to write a letter. IELTS Writing Task 1 - Academic Module You will be given a task based on some.
Download Prevention is better than cure stock photos. Affordable and search from millions of royalty free images, photos and vectors.
Definition of prevention is better than cure in the Idioms Dictionary. prevention is better than cure phrase.. and healthy foods and nutritional supplements go a long way towards keeping the body healthy.. prevention is better than cure; Prevention Minimum Evaluation Data Set.
It is better to prevent the creation of a problem than to have to deal with it afterwards.
Prevention Is Better Than Cure. Do you like this. To be concluded,health education and prevention measure go for long time and affordable by everyone so country's big budget should be invested in education and prevention measure. your essay is just a list of items which are not related to each other. Lexical Resource means.


text:
Astral Jumpsuit
Estimated Delivery : Dec 03 - Dec 04
This item is eligible for FREE returns
Return within 30 days if unopened and unused
- Self: 83% acetate, 17% poly
Lining: 100% poly
- Dry clean only
- Hidden back zipper closure
- Crepe fabric with pleated detail
- Imported
- Revolve Style No. THUR-WC1
- Manufacturer Style No. JU2469
- 33" Inseam
- Modeled in size 8/S.
- Shoulder seam to hem measures approx 60" in length
24" at the knee breaks to 38" at the leg opening
- Model Measurements: Height 5'11.5", Waist 23.5, Bust 34, Hips 36
- Size Guide
If an item you would like to purchase is out of stock, you can place a Special Order Inquiry. REVOLVE will then check the availability and obtain an approximate arrival date for the item, if available. Typically, it takes up to 3-4 weeks to verify this information.
Placing a Special Order Inquiry is absolutely free and there is no obligation to follow through with a purchase.
- You will be notified by email once we receive the item.
- You may cancel at any time without penalty
- Your card will ONLY be charged when your order is shipped.
- Availability is not guaranteed.


text:
BBMi Solar Deck Light,Driveway LED Dock Lights Solar Powered,IP68 Waterproof LED Road Markers Wireless,Outdoor Lighting for Sold by GrowKart $23.97
BBMi Solar Deck Light,Driveway LED Dock Lights Solar Powered,IP68 Waterproof LED Road Markers Wireless,Outdoor Lighting for Sold by GrowKart $23.97
" These easy to install solar path lights illuminate your driveway, walkway, garden, sidewalk and more with bright white LED light! Make this your ideal light to illuminate your deck, dock, stairs, or driveway. "
Find many great new & used options and get the best deals for LED Solar Powered Pathway Lights - Pack of 8 at the best online prices at eBay! Free shipping for many products!
Solar Post Caps and Rail Lights Solar Deck Lights are a great way to add character to your deck or walkway. Solar Post Caps are an easy way to add lighting to any deck railing, no wiring necessary. A solar cell charges batteries during the day, resulting in little
Product Title LED Solar Light Sensor Wall Lights 100pcs LED Beads Average rating: 3.8 out of 5 stars, based on 4 reviews 4 ratings Current Price $11.55 $ 11 . 55 List List Price $23.10 $ 23 . 10
Find Solar outdoor lighting at Lowe's today. Shop outdoor lighting and a variety of lighting & ceiling fans products online at Lowes.com. Westinghouse 120-Degree 2000-Lumen White Solar Integrated LED Motion-Activated Flood Light with Timer (2-Pack)
8 White 5 x 5 Solar LED Post Light Deck Cap Fence Landscape Lamp PVC Vinyl Wood (21) $74.99 New---- Used Costech Solar Lights Motion Sensor 182 LED 1000 Lumens Outdoor Weatherproof - Black (71) $39.99 New---- Used Caesar Plaza 5" x 5" Square
Rechargeable , Solar Brick LED , Garden Lights , Deck, Patio and Pool Lights , water resistant, sidewalk, walkway, driveway, outdoor lighting Subscribe to our newsletter And stay
Trex LED Deck Rail Light Starting at: As low as $62.99 Price depends on product options. Make a selection to update price. Add to Cart Odyssey LED Strip Light by Aurora Deck Lighting
The LED Solar Light Bulb is an economical solar R 99.00 Add to Cart Party Light - Pink Solar LED Chinese Lantern ... Black lantern with white LED light. Perfect for... R 199.00 Add to Cart Sale Solsave My Lite SolSave My-Lite - Revolutionary ...
JACKYLED Solar Docks have a sleek, modern, down-to-business design. The LED light emitted is unusually bright, allowing for a high-visibility for driveways that require it. The light is visible for up to 875 yards, which is perfect for anyone with a long driveway.
The light is IP68(submersible) waterproof rated and has a weight rating exceeding 30 tons making it suitable for roadway installations. Solar Road Markers or lane/pavement markers are a low-cost, self-contained, solar-rechargeable, LED illuminated marker.
8 light outdoor Paver Dot light kit designed for patio, walkway, driveway and pool decks. These versatile LED lights are designed to be embedded in stone, concrete and pavers. Our convenient Paver Dot™ kit includes a waterproof LED transformer and our standard 5ft or 10ft Plug-N-Play cables.
Indoor Light Kits Solar Animal Repellers Solar Bollards Solar Deck Lights Solar Fence Cap Lights Solar Pool Accessories Solar USB Chargers 1-800-985-4129 | email@example.com Sign In | Register Categories About Us Contact Us Why Buy From 0 0
Shop our best selection of Outdoor Solar Lights to reflect your style and inspire your home. Find lighting you love at Hayneedle, where you can buy online while you explore our room designs and curated looks for tips, ideas & inspiration to help you along the way.


text:
Skip to main content
Open Access Publications from the University of California
About eScholarship
Main Menu
About eScholarship
eScholarship Repository
eScholarship Publishing
Site policies
Terms of Use and Copyright Information
Privacy statement
Campus Sites
Main Menu
UC Berkeley
UC Davis
UC Irvine
UC Merced
UC Riverside
UC San Diego
UC Santa Barbara
UC Santa Cruz
UC Office of the President
Lawrence Berkeley National Laboratory
UC Agriculture & Natural Resources
UC Open Access Policies
eScholarship Publishing
Scholarly Works (7 results)
Sort By:
A-Z By Title
Z-A By Title
A-Z By Author
Z-A By Author
Date Ascending
Date Descending
Peer Reviewed
A genome-wide association study of early menopause and the combined impact of identified variants.
Perry, John RB
Corre, Tanguy
Esko, Tõnu
Chasman, Daniel I
Fischer, Krista
Franceschini, Nora
He, Chunyan
Kutalik, Zoltan
Mangino, Massimo
Rose, Lynda M
Vernon Smith, Albert
Stolk, Lisette
Sulem, Patrick
Weedon, Michael N
Zhuang, Wei V
Arnold, Alice
Ashworth, Alan
Bergmann, Sven
Buring, Julie E
Burri, Andrea
Chen, Constance
Cornelis, Marilyn C
Couper, David J
Goodarzi, Mark O
Gudnason, Vilmundur
Harris, Tamara
Hofman, Albert
Jones, Michael
Kraft, Peter
Launer, Lenore
Laven, Joop SE
Li, Guo
McKnight, Barbara
Masciullo, Corrado
Milani, Lili
Orr, Nicholas
Psaty, Bruce M
ReproGen Consortium
Ridker, Paul M
Rivadeneira, Fernando
Sala, Cinzia
Salumets, Andres
Schoemaker, Minouk
Traglia, Michela
Waeber, Gérard
Chanock, Stephen J
Demerath, Ellen W
Garcia, Melissa
Hankinson, Susan E
Hu, Frank B
Hunter, David J
Lunetta, Kathryn L
Metspalu, Andres
Montgomery, Grant W
Murabito, Joanne M
Newman, Anne B
Ong, Ken K
Spector, Tim D
Stefansson, Kari
Swerdlow, Anthony J
Thorsteinsdottir, Unnur
Van Dam, Rob M
Uitterlinden, André G
Visser, Jenny A
Vollenweider, Peter
Toniolo, Daniela
Murray, Anna
et al.
UCLA Previously Published Works
Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women who postpone their first pregnancy beyond the age of 30 years. The genetic aetiology of EM is largely unknown in the majority of cases. We have undertaken a meta-analysis of genome-wide association studies (GWASs) in 3493 EM cases and 13 598 controls from 10 independent studies. No novel genetic variants were discovered, but the 17 variants previously associated with normal age at natural menopause as a quantitative trait (QT) were also associated with EM and primary ovarian insufficiency (POI). Thus, EM has a genetic aetiology which overlaps variation in normal age at menopause and is at least partly explained by the additive effects of the same polygenic variants. The combined effect of the common variants captured by the single nucleotide polymorphism arrays was estimated to account for ∼30% of the variance in EM. The association between the combined 17 variants and the risk of EM was greater than the best validated non-genetic risk factor, smoking.
Peer Reviewed
Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.
Khalili, Hamed
Gong, Jian
Brenner, Hermann
Austin, Thomas R
Hutter, Carolyn M
Baba, Yoshifumi
Baron, John A
Berndt, Sonja I
Bézieau, Stéphane
Caan, Bette
Campbell, Peter T
Chang-Claude, Jenny
Chanock, Stephen J
Chen, Constance
Hsu, Li
Jiao, Shuo
Conti, David V
Duggan, David
Fuchs, Charles S
Gala, Manish
Gallinger, Steven
Haile, Robert W
Harrison, Tabitha A
Hayes, Richard
Hazra, Aditi
Henderson, Brian
Haiman, Chris
Hoffmeister, Michael
Hopper, John L
Jenkins, Mark A
Kolonel, Laurence N
Küry, Sébastien
LaCroix, Andrea
Marchand, Loic Le
Lemire, Mathieu
Lindor, Noralane M
Ma, Jing
Manson, JoAnn E
Morikawa, Teppei
Nan, Hongmei
Ng, Kimmie
Newcomb, Polly A
Nishihara, Reiko
Potter, John D
Qu, Conghui
Schoen, Robert E
Schumacher, Fredrick R
Seminara, Daniela
Taverna, Darin
Thibodeau, Stephen
Wactawski-Wende, Jean
White, Emily
Wu, Kana
Zanke, Brent W
Casey, Graham
Hudson, Thomas J
Kraft, Peter
Peters, Ulrike
Slattery, Martha L
Ogino, Shuji
Chan, Andrew T
GECCO and CCFR
et al.
UC San Diego Previously Published Works
Although genome-wide association studies (GWAS) have separately identified many genetic susceptibility loci for ulcerative colitis (UC), Crohn's disease (CD) and colorectal cancer (CRC), there has been no large-scale examination for pleiotropy, or shared genetic susceptibility, for these conditions. We used logistic regression modeling to examine the associations of 181 UC and CD susceptibility variants previously identified by GWAS with risk of CRC using data from the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. We also examined associations of significant variants with clinical and molecular characteristics in a subset of the studies. Among 11794 CRC cases and 14190 controls, rs11676348, the susceptibility single nucleotide polymorphism (SNP) for UC, was significantly associated with reduced risk of CRC (P = 7E-05). The multivariate-adjusted odds ratio of CRC with each copy of the T allele was 0.93 (95% CI 0.89-0.96). The association of the SNP with risk of CRC differed according to mucinous histological features (P heterogeneity = 0.008). In addition, the (T) allele was associated with lower risk of tumors with Crohn's-like reaction but not tumors without such immune infiltrate (P heterogeneity = 0.02) and microsatellite instability-high (MSI-high) but not microsatellite stable or MSI-low tumors (P heterogeneity = 0.03). The minor allele (T) in SNP rs11676348, located downstream from CXCR2 that has been implicated in CRC progression, is associated with a lower risk of CRC, particularly tumors with a mucinous component, Crohn's-like reaction and MSI-high. Our findings offer the promise of risk stratification of inflammatory bowel disease patients for complications such as CRC.
Peer Reviewed
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Machiela, Mitchell J
Zhou, Weiyin
Karlins, Eric
Sampson, Joshua N
Freedman, Neal D
Yang, Qi
Hicks, Belynda
Dagnall, Casey
Hautman, Christopher
Jacobs, Kevin B
Abnet, Christian C
Aldrich, Melinda C
Amos, Christopher
Amundadottir, Laufey T
Arslan, Alan A
Beane-Freeman, Laura E
Berndt, Sonja I
Black, Amanda
Blot, William J
Bock, Cathryn H
Bracci, Paige M
Brinton, Louise A
Bueno-de-Mesquita, H Bas
Burdett, Laurie
Buring, Julie E
Butler, Mary A
Canzian, Federico
Carreon, Tania
Chaffee, Kari G
Chang, I-Shou
Chatterjee, Nilanjan
Chen, Chu
Chen, Constance
Chen, Kexin
Chung, Charles C
Cook, Linda S
Bou, Marta Crous
Cullen, Michael
Davis, Faith G
De Vivo, Immaculata
Ding, Ti
Doherty, Jennifer
Duell, Eric J
Epstein, Caroline G
Fan, Jin-Hu
Figueroa, Jonine D
Fraumeni, Joseph F
Friedenreich, Christine M
Fuchs, Charles S
Gallinger, Steven
Gao, Yu-Tang
Gapstur, Susan M
Garcia-Closas, Montserrat
Gaudet, Mia M
Gaziano, J Michael
Giles, Graham G
Gillanders, Elizabeth M
Giovannucci, Edward L
Goldin, Lynn
Goldstein, Alisa M
Haiman, Christopher A
Hallmans, Goran
Hankinson, Susan E
Harris, Curtis C
Henriksson, Roger
Holly, Elizabeth A
Hong, Yun-Chul
Hoover, Robert N
Hsiung, Chao A
Hu, Nan
Hu, Wei
Hunter, David J
Hutchinson, Amy
Jenab, Mazda
Johansen, Christoffer
Khaw, Kay-Tee
Kim, Hee Nam
Kim, Yeul Hong
Kim, Young Tae
Klein, Alison P
Klein, Robert
Koh, Woon-Puay
Kolonel, Laurence N
Kooperberg, Charles
Kraft, Peter
Krogh, Vittorio
Kurtz, Robert C
LaCroix, Andrea
Lan, Qing
Landi, Maria Teresa
Le Marchand, Loic
Li, Donghui
Liang, Xiaolin
Liao, Linda M
Lin, Dongxin
Liu, Jianjun
Lissowska, Jolanta
Lu, Lingeng
Magliocco, Anthony M
Malats, Nuria
Matsuo, Keitaro
McNeill, Lorna H
McWilliams, Robert R
Melin, Beatrice S
Mirabello, Lisa
Moore, Lee
Olson, Sara H
Orlow, Irene
Park, Jae Yong
Patino-Garcia, Ana
Peplonska, Beata
Peters, Ulrike
Petersen, Gloria M
Pooler, Loreall
Prescott, Jennifer
Prokunina-Olsson, Ludmila
Purdue, Mark P
Qiao, You-Lin
Rajaraman, Preetha
Real, Francisco X
Riboli, Elio
Risch, Harvey A
Rodriguez-Santiago, Benjamin
Ruder, Avima M
Savage, Sharon A
Schumacher, Fredrick
Schwartz, Ann G
Schwartz, Kendra L
Seow, Adeline
Setiawan, Veronica Wendy
Severi, Gianluca
Shen, Hongbing
Sheng, Xin
Shin, Min-Ho
Shu, Xiao-Ou
Silverman, Debra T
Spitz, Margaret R
Stevens, Victoria L
Stolzenberg-Solomon, Rachael
Stram, Daniel
Tang, Ze-Zhong
Taylor, Philip R
Teras, Lauren R
Tobias, Geoffrey S
Van den Berg, David
Visvanathan, Kala
Wacholder, Sholom
Wang, Jiu-Cun
Wang, Zhaoming
Wentzensen, Nicolas
Wheeler, William
White, Emily
Wiencke, John K
Wolpin, Brian M
Wong, Maria Pik
Wu, Chen
Wu, Tangchun
Wu, Xifeng
Wu, Yi-Long
Wunder, Jay S
Xia, Lucy
Yang, Hannah P
Yang, Pan-Chyr
Yu, Kai
Zanetti, Krista A
Zeleniuch-Jacquotte, Anne
Zheng, Wei
Zhou, Baosen
Ziegler, Regina G
Perez-Jurado, Luis A
Caporaso, Neil E
Rothman, Nathaniel
Tucker, Margaret
Dean, Michael C
Yeager, Meredith
Chanock, Stephen J
et al.
UC San Diego Previously Published Works
Peer Reviewed
Characterization of large structural genetic mosaicism in human autosomes.
Machiela, Mitchell J
Zhou, Weiyin
Sampson, Joshua N
Dean, Michael C
Jacobs, Kevin B
Black, Amanda
Brinton, Louise A
Chang, I-Shou
Chen, Chu
Chen, Constance
Chen, Kexin
Cook, Linda S
Crous Bou, Marta
De Vivo, Immaculata
Doherty, Jennifer
Friedenreich, Christine M
Gaudet, Mia M
Haiman, Christopher A
Hankinson, Susan E
Hartge, Patricia
Henderson, Brian E
Hong, Yun-Chul
Hosgood, H Dean
Hsiung, Chao A
Hu, Wei
Hunter, David J
Jessop, Lea
Kim, Hee Nam
Kim, Yeul Hong
Kim, Young Tae
Klein, Robert
Kraft, Peter
Lan, Qing
Lin, Dongxin
Liu, Jianjun
Le Marchand, Loic
Liang, Xiaolin
Lissowska, Jolanta
Lu, Lingeng
Magliocco, Anthony M
Matsuo, Keitaro
Olson, Sara H
Orlow, Irene
Park, Jae Yong
Pooler, Loreall
Prescott, Jennifer
Rastogi, Radhai
Risch, Harvey A
Schumacher, Fredrick
Seow, Adeline
Setiawan, Veronica Wendy
Shen, Hongbing
Sheng, Xin
Shin, Min-Ho
Shu, Xiao-Ou
VanDen Berg, David
Wang, Jiu-Cun
Wentzensen, Nicolas
Wong, Maria Pik
Wu, Chen
Wu, Tangchun
Wu, Yi-Long
Xia, Lucy
Yang, Hannah P
Yang, Pan-Chyr
Zheng, Wei
Zhou, Baosen
Abnet, Christian C
Albanes, Demetrius
Aldrich, Melinda C
Amos, Christopher
Amundadottir, Laufey T
Berndt, Sonja I
Blot, William J
Bock, Cathryn H
Bracci, Paige M
Burdett, Laurie
Buring, Julie E
Butler, Mary A
Carreón, Tania
Chatterjee, Nilanjan
Chung, Charles C
Cook, Michael B
Cullen, Michael
Davis, Faith G
Ding, Ti
Duell, Eric J
Epstein, Caroline G
Fan, Jin-Hu
Figueroa, Jonine D
Fraumeni, Joseph F
Freedman, Neal D
Fuchs, Charles S
Gao, Yu-Tang
Gapstur, Susan M
Patiño-Garcia, Ana
Garcia-Closas, Montserrat
Gaziano, J Michael
Giles, Graham G
Gillanders, Elizabeth M
Giovannucci, Edward L
Goldin, Lynn
Goldstein, Alisa M
Greene, Mark H
Hallmans, Goran
Harris, Curtis C
Henriksson, Roger
Holly, Elizabeth A
Hoover, Robert N
Hu, Nan
Hutchinson, Amy
Jenab, Mazda
Johansen, Christoffer
Khaw, Kay-Tee
Koh, Woon-Puay
Kolonel, Laurence N
Kooperberg, Charles
Krogh, Vittorio
Kurtz, Robert C
LaCroix, Andrea
Landgren, Annelie
Landi, Maria Teresa
Li, Donghui
Liao, Linda M
Malats, Nuria
McGlynn, Katherine A
McNeill, Lorna H
McWilliams, Robert R
Melin, Beatrice S
Mirabello, Lisa
Peplonska, Beata
Peters, Ulrike
Petersen, Gloria M
Prokunina-Olsson, Ludmila
Purdue, Mark
Qiao, You-Lin
Rabe, Kari G
Rajaraman, Preetha
Real, Francisco X
Riboli, Elio
Rodríguez-Santiago, Benjamín
Rothman, Nathaniel
Ruder, Avima M
Savage, Sharon A
Schwartz, Ann G
Schwartz, Kendra L
Sesso, Howard D
Severi, Gianluca
Silverman, Debra T
Spitz, Margaret R
Stevens, Victoria L
Stolzenberg-Solomon, Rachael
Stram, Daniel
Tang, Ze-Zhong
Taylor, Philip R
Teras, Lauren R
Tobias, Geoffrey S
Viswanathan, Kala
Wacholder, Sholom
Wang, Zhaoming
Weinstein, Stephanie J
Wheeler, William
White, Emily
Wiencke, John K
Wolpin, Brian M
Wu, Xifeng
Wunder, Jay S
Yu, Kai
Zanetti, Krista A
Zeleniuch-Jacquotte, Anne
Ziegler, Regina G
de Andrade, Mariza
Barnes, Kathleen C
Beaty, Terri H
Bierut, Laura J
Desch, Karl C
Doheny, Kimberly F
Feenstra, Bjarke
Ginsburg, David
Heit, John A
Kang, Jae H
Laurie, Cecilia A
Li, Jun Z
Lowe, William L
Marazita, Mary L
Melbye, Mads
Mirel, Daniel B
Murray, Jeffrey C
Nelson, Sarah C
Pasquale, Louis R
Rice, Kenneth
Wiggs, Janey L
Wise, Anastasia
Tucker, Margaret
Pérez-Jurado, Luis A
Laurie, Cathy C
Caporaso, Neil E
Yeager, Meredith
Chanock, Stephen J
et al.
UC San Diego Previously Published Works
Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 × 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
Peer Reviewed
Directional dominance on stature and cognition in diverse human populations.
Joshi, Peter K
Esko, Tonu
Mattsson, Hannele
Eklund, Niina
Gandin, Ilaria
Nutile, Teresa
Jackson, Anne U
Schurmann, Claudia
Smith, Albert V
Zhang, Weihua
Okada, Yukinori
Stančáková, Alena
Faul, Jessica D
Zhao, Wei
Bartz, Traci M
Concas, Maria Pina
Franceschini, Nora
Enroth, Stefan
Vitart, Veronique
Trompet, Stella
Guo, Xiuqing
Chasman, Daniel I
O'Connel, Jeffery R
Corre, Tanguy
Nongmaithem, Suraj S
Chen, Yuning
Mangino, Massimo
Ruggiero, Daniela
Traglia, Michela
Farmaki, Aliki-Eleni
Kacprowski, Tim
Bjonnes, Andrew
van der Spek, Ashley
Wu, Ying
Giri, Anil K
Yanek, Lisa R
Wang, Lihua
Hofer, Edith
Rietveld, Cornelius A
McLeod, Olga
Cornelis, Marilyn C
Pattaro, Cristian
Verweij, Niek
Baumbach, Clemens
Abdellaoui, Abdel
Warren, Helen R
Vuckovic, Dragana
Mei, Hao
Bouchard, Claude
Perry, John RB
Cappellani, Stefania
Mirza, Saira S
Benton, Miles C
Broeckel, Ulrich
Medland, Sarah E
Lind, Penelope A
Malerba, Giovanni
Drong, Alexander
Yengo, Loic
Bielak, Lawrence F
Zhi, Degui
van der Most, Peter J
Shriner, Daniel
Mägi, Reedik
Hemani, Gibran
Karaderi, Tugce
Wang, Zhaoming
Liu, Tian
Demuth, Ilja
Zhao, Jing Hua
Meng, Weihua
Lataniotis, Lazaros
van der Laan, Sander W
Bradfield, Jonathan P
Wood, Andrew R
Bonnefond, Amelie
Ahluwalia, Tarunveer S
Hall, Leanne M
Salvi, Erika
Yazar, Seyhan
Carstensen, Lisbeth
de Haan, Hugoline G
Abney, Mark
Afzal, Uzma
Allison, Matthew A
Amin, Najaf
Asselbergs, Folkert W
Bakker, Stephan JL
Barr, R Graham
Baumeister, Sebastian E
Benjamin, Daniel J
Bergmann, Sven
Boerwinkle, Eric
Bottinger, Erwin P
Campbell, Archie
Chakravarti, Aravinda
Chan, Yingleong
Chanock, Stephen J
Chen, Constance
Chen, Y-D Ida
Collins, Francis S
Connell, John
Correa, Adolfo
Cupples, L Adrienne
Smith, George Davey
Davies, Gail
Dörr, Marcus
Ehret, Georg
Ellis, Stephen B
Feenstra, Bjarke
Feitosa, Mary F
Ford, Ian
Fox, Caroline S
Frayling, Timothy M
Friedrich, Nele
Geller, Frank
Scotland, Generation
Gillham-Nasenya, Irina
Gottesman, Omri
Graff, Misa
Grodstein, Francine
Gu, Charles
Haley, Chris
Hammond, Christopher J
Harris, Sarah E
Harris, Tamara B
Hastie, Nicholas D
Heard-Costa, Nancy L
Heikkilä, Kauko
Hocking, Lynne J
Homuth, Georg
Hottenga, Jouke-Jan
Huang, Jinyan
Huffman, Jennifer E
Hysi, Pirro G
Ikram, M Arfan
Ingelsson, Erik
Joensuu, Anni
Johansson, Åsa
Jousilahti, Pekka
Jukema, J Wouter
Kähönen, Mika
Kamatani, Yoichiro
Kanoni, Stavroula
Kerr, Shona M
Khan, Nazir M
Koellinger, Philipp
Koistinen, Heikki A
Kooner, Manraj K
Kubo, Michiaki
Kuusisto, Johanna
Lahti, Jari
Launer, Lenore J
Lea, Rodney A
Lehne, Benjamin
Lehtimäki, Terho
Liewald, David CM
Lind, Lars
Loh, Marie
Lokki, Marja-Liisa
London, Stephanie J
Loomis, Stephanie J
Loukola, Anu
Lu, Yingchang
Lumley, Thomas
Lundqvist, Annamari
Männistö, Satu
Marques-Vidal, Pedro
Masciullo, Corrado
Matchan, Angela
Mathias, Rasika A
Matsuda, Koichi
Meigs, James B
Meisinger, Christa
Meitinger, Thomas
Menni, Cristina
Mentch, Frank D
Mihailov, Evelin
Milani, Lili
Montasser, May E
Montgomery, Grant W
Morrison, Alanna
Myers, Richard H
Nadukuru, Rajiv
Navarro, Pau
Nelis, Mari
Nieminen, Markku S
Nolte, Ilja M
O'Connor, George T
Ogunniyi, Adesola
Padmanabhan, Sandosh
Palmas, Walter R
Pankow, James S
Patarcic, Inga
Pavani, Francesca
Peyser, Patricia A
Pietilainen, Kirsi
Poulter, Neil
Prokopenko, Inga
Ralhan, Sarju
Redmond, Paul
Rich, Stephen S
Rissanen, Harri
Robino, Antonietta
Rose, Lynda M
Rose, Richard
Sala, Cinzia
Salako, Babatunde
Salomaa, Veikko
Sarin, Antti-Pekka
Saxena, Richa
Schmidt, Helena
Scott, Laura J
Scott, William R
Sennblad, Bengt
Seshadri, Sudha
Sever, Peter
Shrestha, Smeeta
Smith, Blair H
Smith, Jennifer A
Soranzo, Nicole
Sotoodehnia, Nona
Southam, Lorraine
Stanton, Alice V
Stathopoulou, Maria G
Strauch, Konstantin
Strawbridge, Rona J
Suderman, Matthew J
Tandon, Nikhil
Tang, Sian-Tsun
Taylor, Kent D
Tayo, Bamidele O
Töglhofer, Anna Maria
Tomaszewski, Maciej
Tšernikova, Natalia
Tuomilehto, Jaakko
Uitterlinden, Andre G
Vaidya, Dhananjay
van Hylckama Vlieg, Astrid
van Setten, Jessica
Vasankari, Tuula
Vedantam, Sailaja
Vlachopoulou, Efthymia
Vozzi, Diego
Vuoksimaa, Eero
Waldenberger, Melanie
Ware, Erin B
Wentworth-Shields, William
Whitfield, John B
Wild, Sarah
Willemsen, Gonneke
Yajnik, Chittaranjan S
Yao, Jie
Zaza, Gianluigi
Zhu, Xiaofeng
Project, The BioBank Japan
Salem, Rany M
Melbye, Mads
Bisgaard, Hans
Samani, Nilesh J
Cusi, Daniele
Mackey, David A
Cooper, Richard S
Froguel, Philippe
Pasterkamp, Gerard
Grant, Struan FA
Hakonarson, Hakon
Ferrucci, Luigi
Scott, Robert A
Morris, Andrew D
Palmer, Colin NA
Dedoussis, George
Deloukas, Panos
Bertram, Lars
Lindenberger, Ulman
Berndt, Sonja I
Lindgren, Cecilia M
Timpson, Nicholas J
Tönjes, Anke
Munroe, Patricia B
Sørensen, Thorkild IA
Rotimi, Charles N
Arnett, Donna K
Oldehinkel, Albertine J
Kardia, Sharon LR
Balkau, Beverley
Gambaro, Giovanni
Morris, Andrew P
Eriksson, Johan G
Wright, Margie J
Martin, Nicholas G
Hunt, Steven C
Starr, John M
Deary, Ian J
Griffiths, Lyn R
Tiemeier, Henning
Pirastu, Nicola
Kaprio, Jaakko
Wareham, Nicholas J
Pérusse, Louis
Wilson, James G
Girotto, Giorgia
Caulfield, Mark J
Raitakari, Olli
Boomsma, Dorret I
Gieger, Christian
van der Harst, Pim
Hicks, Andrew A
Kraft, Peter
Sinisalo, Juha
Knekt, Paul
Johannesson, Magnus
Magnusson, Patrik KE
Hamsten, Anders
Schmidt, Reinhold
Borecki, Ingrid B
Vartiainen, Erkki
Becker, Diane M
Bharadwaj, Dwaipayan
Mohlke, Karen L
Boehnke, Michael
van Duijn, Cornelia M
Sanghera, Dharambir K
Teumer, Alexander
Zeggini, Eleftheria
Metspalu, Andres
Gasparini, Paolo
Ulivi, Sheila
Ober, Carole
Toniolo, Daniela
Rudan, Igor
Porteous, David J
Ciullo, Marina
Spector, Tim D
Hayward, Caroline
Dupuis, Josée
Loos, Ruth JF
Wright, Alan F
Chandak, Giriraj R
Vollenweider, Peter
Shuldiner, Alan
Ridker, Paul M
Rotter, Jerome I
Sattar, Naveed
Gyllensten, Ulf
North, Kari E
Pirastu, Mario
Psaty, Bruce M
Weir, David R
Laakso, Markku
Gudnason, Vilmundur
Takahashi, Atsushi
Chambers, John C
Kooner, Jaspal S
Strachan, David P
Campbell, Harry
Hirschhorn, Joel N
Perola, Markus
Polašek, Ozren
Wilson, James F
et al.
UCLA Previously Published Works
Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
Peer Reviewed
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Lango Allen, Hana
Estrada, Karol
Lettre, Guillaume
Berndt, Sonja I
Weedon, Michael N
Rivadeneira, Fernando
Willer, Cristen J
Jackson, Anne U
Vedantam, Sailaja
Raychaudhuri, Soumya
Ferreira, Teresa
Wood, Andrew R
Weyant, Robert J
Segrè, Ayellet V
Speliotes, Elizabeth K
Wheeler, Eleanor
Soranzo, Nicole
Park, Ju-Hyun
Yang, Jian
Gudbjartsson, Daniel
Heard-Costa, Nancy L
Randall, Joshua C
Qi, Lu
Vernon Smith, Albert
Mägi, Reedik
Pastinen, Tomi
Liang, Liming
Heid, Iris M
Luan, Jian'an
Thorleifsson, Gudmar
Winkler, Thomas W
Goddard, Michael E
Sin Lo, Ken
Palmer, Cameron
Workalemahu, Tsegaselassie
Aulchenko, Yurii S
Johansson, Asa
Zillikens, M Carola
Feitosa, Mary F
Esko, Tõnu
Johnson, Toby
Ketkar, Shamika
Kraft, Peter
Mangino, Massimo
Prokopenko, Inga
Absher, Devin
Albrecht, Eva
Ernst, Florian
Glazer, Nicole L
Hayward, Caroline
Hottenga, Jouke-Jan
Jacobs, Kevin B
Knowles, Joshua W
Kutalik, Zoltán
Monda, Keri L
Polasek, Ozren
Preuss, Michael
Rayner, Nigel W
Robertson, Neil R
Steinthorsdottir, Valgerdur
Tyrer, Jonathan P
Voight, Benjamin F
Wiklund, Fredrik
Xu, Jianfeng
Zhao, Jing Hua
Nyholt, Dale R
Pellikka, Niina
Perola, Markus
Perry, John RB
Surakka, Ida
Tammesoo, Mari-Liis
Altmaier, Elizabeth L
Amin, Najaf
Aspelund, Thor
Bhangale, Tushar
Boucher, Gabrielle
Chasman, Daniel I
Chen, Constance
Coin, Lachlan
Cooper, Matthew N
Dixon, Anna L
Gibson, Quince
Grundberg, Elin
Hao, Ke
Juhani Junttila, M
Kaplan, Lee M
Kettunen, Johannes
König, Inke R
Kwan, Tony
Lawrence, Robert W
Levinson, Douglas F
Lorentzon, Mattias
McKnight, Barbara
Morris, Andrew P
Müller, Martina
Suh Ngwa, Julius
Purcell, Shaun
Rafelt, Suzanne
Salem, Rany M
Salvi, Erika
Sanna, Serena
Shi, Jianxin
Sovio, Ulla
Thompson, John R
Turchin, Michael C
Vandenput, Liesbeth
Verlaan, Dominique J
Vitart, Veronique
White, Charles C
Ziegler, Andreas
Almgren, Peter
Balmforth, Anthony J
Campbell, Harry
Citterio, Lorena
De Grandi, Alessandro
Dominiczak, Anna
Duan, Jubao
Elliott, Paul
Elosua, Roberto
Eriksson, Johan G
Freimer, Nelson B
Geus, Eco JC
Glorioso, Nicola
Haiqing, Shen
Hartikainen, Anna-Liisa
Havulinna, Aki S
Hicks, Andrew A
Hui, Jennie
Igl, Wilmar
Illig, Thomas
Jula, Antti
Kajantie, Eero
Kilpeläinen, Tuomas O
Koiranen, Markku
Kolcic, Ivana
Koskinen, Seppo
Kovacs, Peter
Laitinen, Jaana
Liu, Jianjun
Lokki, Marja-Liisa
Marusic, Ana
Maschio, Andrea
Meitinger, Thomas
Mulas, Antonella
Paré, Guillaume
Parker, Alex N
Peden, John F
Petersmann, Astrid
Pichler, Irene
Pietiläinen, Kirsi H
Pouta, Anneli
Ridderstråle, Martin
Rotter, Jerome I
Sambrook, Jennifer G
Sanders, Alan R
Schmidt, Carsten Oliver
Sinisalo, Juha
Smit, Jan H
Stringham, Heather M
Bragi Walters, G
Widen, Elisabeth
Wild, Sarah H
Willemsen, Gonneke
Zagato, Laura
Zgaga, Lina
Zitting, Paavo
Alavere, Helene
Farrall, Martin
McArdle, Wendy L
Nelis, Mari
Peters, Marjolein J
Ripatti, Samuli
van Meurs, Joyce BJ
Aben, Katja K
Ardlie, Kristin G
Beckmann, Jacques S
Beilby, John P
Bergman, Richard N
Bergmann, Sven
Collins, Francis S
Cusi, Daniele
den Heijer, Martin
Eiriksdottir, Gudny
Gejman, Pablo V
Hall, Alistair S
Hamsten, Anders
Huikuri, Heikki V
Iribarren, Carlos
Kähönen, Mika
Kaprio, Jaakko
Kathiresan, Sekar
Kiemeney, Lambertus
Kocher, Thomas
Launer, Lenore J
Lehtimäki, Terho
Melander, Olle
Mosley, Tom H
Musk, Arthur W
Nieminen, Markku S
O'Donnell, Christopher J
Ohlsson, Claes
Oostra, Ben
Palmer, Lyle J
Raitakari, Olli
Ridker, Paul M
Rioux, John D
Rissanen, Aila
Rivolta, Carlo
Schunkert, Heribert
Shuldiner, Alan R
Siscovick, David S
Stumvoll, Michael
Tönjes, Anke
Tuomilehto, Jaakko
van Ommen, Gert-Jan
Viikari, Jorma
Heath, Andrew C
Martin, Nicholas G
Montgomery, Grant W
Province, Michael A
Kayser, Manfred
Arnold, Alice M
Atwood, Larry D
Boerwinkle, Eric
Chanock, Stephen J
Deloukas, Panos
Gieger, Christian
Grönberg, Henrik
Hall, Per
Hattersley, Andrew T
Hengstenberg, Christian
Hoffman, Wolfgang
Lathrop, G Mark
Salomaa, Veikko
Schreiber, Stefan
Uda, Manuela
Waterworth, Dawn
Wright, Alan F
Assimes, Themistocles L
Barroso, Inês
Hofman, Albert
Mohlke, Karen L
Boomsma, Dorret I
Caulfield, Mark J
Cupples, L Adrienne
Erdmann, Jeanette
Fox, Caroline S
Gudnason, Vilmundur
Gyllensten, Ulf
Harris, Tamara B
Hayes, Richard B
Jarvelin, Marjo-Riitta
Mooser, Vincent
Munroe, Patricia B
Ouwehand, Willem H
Penninx, Brenda W
Pramstaller, Peter P
Quertermous, Thomas
Rudan, Igor
Samani, Nilesh J
Spector, Timothy D
Völzke, Henry
Watkins, Hugh
Wilson, James F
Groop, Leif C
Haritunians, Talin
Hu, Frank B
Kaplan, Robert C
Metspalu, Andres
North, Kari E
Schlessinger, David
Wareham, Nicholas J
Hunter, David J
O'Connell, Jeffrey R
Strachan, David P
Wichmann, H-Erich
Borecki, Ingrid B
van Duijn, Cornelia M
Schadt, Eric E
Thorsteinsdottir, Unnur
Peltonen, Leena
Uitterlinden, André G
Visscher, Peter M
Chatterjee, Nilanjan
Loos, Ruth JF
Boehnke, Michael
McCarthy, Mark I
Ingelsson, Erik
Lindgren, Cecilia M
Abecasis, Gonçalo R
Stefansson, Kari
Frayling, Timothy M
Hirschhorn, Joel N
et al.
UC San Diego Previously Published Works
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
Peer Reviewed
Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.
Sampson, Joshua N
Wheeler, William A
Yeager, Meredith
Panagiotou, Orestis
Wang, Zhaoming
Berndt, Sonja I
Lan, Qing
Abnet, Christian C
Amundadottir, Laufey T
Figueroa, Jonine D
Landi, Maria Teresa
Mirabello, Lisa
Savage, Sharon A
Taylor, Philip R
De Vivo, Immaculata
McGlynn, Katherine A
Purdue, Mark P
Rajaraman, Preetha
Adami, Hans-Olov
Ahlbom, Anders
Albanes, Demetrius
Amary, Maria Fernanda
An, She-Juan
Andersson, Ulrika
Andriole, Gerald
Andrulis, Irene L
Angelucci, Emanuele
Ansell, Stephen M
Arici, Cecilia
Armstrong, Bruce K
Arslan, Alan A
Austin, Melissa A
Baris, Dalsu
Barkauskas, Donald A
Bassig, Bryan A
Becker, Nikolaus
Benavente, Yolanda
Benhamou, Simone
Berg, Christine
Van Den Berg, David
Bernstein, Leslie
Bertrand, Kimberly A
Birmann, Brenda M
Black, Amanda
Boeing, Heiner
Boffetta, Paolo
Boutron-Ruault, Marie-Christine
Bracci, Paige M
Brinton, Louise
Brooks-Wilson, Angela R
Bueno-de-Mesquita, H Bas
Burdett, Laurie
Buring, Julie
Butler, Mary Ann
Cai, Qiuyin
Cancel-Tassin, Geraldine
Canzian, Federico
Carrato, Alfredo
Carreon, Tania
Carta, Angela
Chan, John KC
Chang, Ellen T
Chang, Gee-Chen
Chang, I-Shou
Chang, Jiang
Chang-Claude, Jenny
Chen, Chien-Jen
Chen, Chih-Yi
Chen, Chu
Chen, Chung-Hsing
Chen, Constance
Chen, Hongyan
Chen, Kexin
Chen, Kuan-Yu
Chen, Kun-Chieh
Chen, Ying
Chen, Ying-Hsiang
Chen, Yi-Song
Chen, Yuh-Min
Chien, Li-Hsin
Chirlaque, María-Dolores
Choi, Jin Eun
Choi, Yi Young
Chow, Wong-Ho
Chung, Charles C
Clavel, Jacqueline
Clavel-Chapelon, Françoise
Cocco, Pierluigi
Colt, Joanne S
Comperat, Eva
Conde, Lucia
Connors, Joseph M
Conti, David
Cortessis, Victoria K
Cotterchio, Michelle
Cozen, Wendy
Crouch, Simon
Crous-Bou, Marta
Cussenot, Olivier
Davis, Faith G
Ding, Ti
Diver, W Ryan
Dorronsoro, Miren
Dossus, Laure
Duell, Eric J
Ennas, Maria Grazia
Erickson, Ralph L
Feychting, Maria
Flanagan, Adrienne M
Foretova, Lenka
Fraumeni, Joseph F
Freedman, Neal D
Beane Freeman, Laura E
Fuchs, Charles
Gago-Dominguez, Manuela
Gallinger, Steven
Gao, Yu-Tang
Gapstur, Susan M
Garcia-Closas, Montserrat
García-Closas, Reina
Gascoyne, Randy D
Gastier-Foster, Julie
Gaudet, Mia M
Gaziano, J Michael
Giffen, Carol
Giles, Graham G
Giovannucci, Edward
Glimelius, Bengt
Goggins, Michael
Gokgoz, Nalan
Goldstein, Alisa M
Gorlick, Richard
Gross, Myron
Grubb, Robert
Gu, Jian
Guan, Peng
Gunter, Marc
Guo, Huan
Habermann, Thomas M
Haiman, Christopher A
Halai, Dina
Hallmans, Goran
Hassan, Manal
Hattinger, Claudia
He, Qincheng
He, Xingzhou
Helzlsouer, Kathy
Henderson, Brian
Henriksson, Roger
Hjalgrim, Henrik
Hoffman-Bolton, Judith
Hohensee, Chancellor
Holford, Theodore R
Holly, Elizabeth A
Hong, Yun-Chul
Hoover, Robert N
Horn-Ross, Pamela L
Hosain, GM Monawar
Hosgood, H Dean
Hsiao, Chin-Fu
Hu, Nan
Hu, Wei
Hu, Zhibin
Huang, Ming-Shyan
Huerta, Jose-Maria
Hung, Jen-Yu
Hutchinson, Amy
Inskip, Peter D
Jackson, Rebecca D
Jacobs, Eric J
Jenab, Mazda
Jeon, Hyo-Sung
Ji, Bu-Tian
Jin, Guangfu
Jin, Li
Johansen, Christoffer
Johnson, Alison
Jung, Yoo Jin
Kaaks, Rudolph
Kamineni, Aruna
Kane, Eleanor
Kang, Chang Hyun
Karagas, Margaret R
Kelly, Rachel S
Khaw, Kay-Tee
Kim, Christopher
Kim, Hee Nam
Kim, Jin Hee
Kim, Jun Suk
Kim, Yeul Hong
Kim, Young Tae
Kim, Young-Chul
Kitahara, Cari M
Klein, Alison P
Klein, Robert J
Kogevinas, Manolis
Kohno, Takashi
Kolonel, Laurence N
Kooperberg, Charles
Kricker, Anne
Krogh, Vittorio
Kunitoh, Hideo
Kurtz, Robert C
Kweon, Sun-Seog
LaCroix, Andrea
Lawrence, Charles
Lecanda, Fernando
Lee, Victor Ho Fun
Li, Donghui
Li, Haixin
Li, Jihua
Li, Yao-Jen
Li, Yuqing
Liao, Linda M
Liebow, Mark
Lightfoot, Tracy
Lim, Wei-Yen
Lin, Chien-Chung
Lin, Dongxin
Lindstrom, Sara
Linet, Martha S
Link, Brian K
Liu, Chenwei
Liu, Jianjun
Liu, Li
Ljungberg, Börje
Lloreta, Josep
Di Lollo, Simonetta
Lu, Daru
Lund, Eiluv
Malats, Nuria
Mannisto, Satu
Le Marchand, Loic
Marina, Neyssa
Masala, Giovanna
Mastrangelo, Giuseppe
Matsuo, Keitaro
Maynadie, Marc
McKay, James
McKean-Cowdin, Roberta
Melbye, Mads
Melin, Beatrice S
Michaud, Dominique S
Mitsudomi, Tetsuya
Monnereau, Alain
Montalvan, Rebecca
Moore, Lee E
Mortensen, Lotte Maxild
Nieters, Alexandra
North, Kari E
Novak, Anne J
Oberg, Ann L
Offit, Kenneth
Oh, In-Jae
Olson, Sara H
Palli, Domenico
Pao, William
Park, In Kyu
Park, Jae Yong
Park, Kyong Hwa
Patiño-Garcia, Ana
Pavanello, Sofia
Peeters, Petra HM
Perng, Reury-Perng
Peters, Ulrike
Petersen, Gloria M
Picci, Piero
Pike, Malcolm C
Porru, Stefano
Prescott, Jennifer
Prokunina-Olsson, Ludmila
Qian, Biyun
Qiao, You-Lin
Rais, Marco
Riboli, Elio
Riby, Jacques
Risch, Harvey A
Rizzato, Cosmeri
Rodabough, Rebecca
Roman, Eve
Roupret, Morgan
Ruder, Avima M
Sanjose, Silvia de
Scelo, Ghislaine
Schned, Alan
Schumacher, Fredrick
Schwartz, Kendra
Schwenn, Molly
Scotlandi, Katia
Seow, Adeline
Serra, Consol
Serra, Massimo
Sesso, Howard D
Setiawan, Veronica Wendy
Severi, Gianluca
Severson, Richard K
Shanafelt, Tait D
Shen, Hongbing
Shen, Wei
Shin, Min-Ho
Shiraishi, Kouya
Shu, Xiao-Ou
Siddiq, Afshan
Sierrasesúmaga, Luis
Sihoe, Alan Dart Loon
Skibola, Christine F
Smith, Alex
Smith, Martyn T
Southey, Melissa C
Spinelli, John J
Staines, Anthony
Stampfer, Meir
Stern, Marianna C
Stevens, Victoria L
Stolzenberg-Solomon, Rachael S
Su, Jian
Su, Wu-Chou
Sund, Malin
Sung, Jae Sook
Sung, Sook Whan
Tan, Wen
Tang, Wei
Tardón, Adonina
Thomas, David
Thompson, Carrie A
Tinker, Lesley F
Tirabosco, Roberto
Tjønneland, Anne
Travis, Ruth C
Trichopoulos, Dimitrios
Tsai, Fang-Yu
Tsai, Ying-Huang
Tucker, Margaret
Turner, Jenny
Vajdic, Claire M
Vermeulen, Roel CH
Villano, Danylo J
Vineis, Paolo
Virtamo, Jarmo
Visvanathan, Kala
Wactawski-Wende, Jean
Wang, Chaoyu
Wang, Chih-Liang
Wang, Jiu-Cun
Wang, Junwen
Wei, Fusheng
Weiderpass, Elisabete
Weiner, George J
Weinstein, Stephanie
Wentzensen, Nicolas
White, Emily
Witzig, Thomas E
Wolpin, Brian M
Wong, Maria Pik
Wu, Chen
Wu, Guoping
Wu, Junjie
Wu, Tangchun
Wu, Wei
Wu, Xifeng
Wu, Yi-Long
Wunder, Jay S
Xiang, Yong-Bing
Xu, Jun
Xu, Ping
Yang, Pan-Chyr
Yang, Tsung-Ying
Ye, Yuanqing
Yin, Zhihua
Yokota, Jun
Yoon, Ho-Il
Yu, Chong-Jen
Yu, Herbert
Yu, Kai
Yuan, Jian-Min
Zelenetz, Andrew
Zeleniuch-Jacquotte, Anne
Zhang, Xu-Chao
Zhang, Yawei
Zhao, Xueying
Zhao, Zhenhong
Zheng, Hong
Zheng, Tongzhang
Zheng, Wei
Zhou, Baosen
Zhu, Meng
Zucca, Mariagrazia
Boca, Simina M
Cerhan, James R
Ferri, Giovanni M
Hartge, Patricia
Hsiung, Chao Agnes
Magnani, Corrado
Miligi, Lucia
Morton, Lindsay M
Smedby, Karin E
Teras, Lauren R
Vijai, Joseph
Wang, Sophia S
Brennan, Paul
Caporaso, Neil E
Hunter, David J
Kraft, Peter
Rothman, Nathaniel
Silverman, Debra T
Slager, Susan L
Chanock, Stephen J
Chatterjee, Nilanjan
et al.
Recent Work
BACKGROUND:Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. METHODS:Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. RESULTS:GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. CONCLUSION:Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.