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GATE Chemical Engineering Syllabus for 2021 CH PDF ...
GATE Chemical Engineering Syllabus 2020 – Core Subject. GATE CH or Chemical Engineering domain paper is being given by the candidates who all are experts in this domain. They have tried a lot in their degree course to excel. With GATE, they can do much better by preparing well for the exam. The engineering domain topics to be studied for the ...Get Price
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Engineering is the discipline and profession that applies scientific theories, mathematical methods, and empirical evidence to design, create, and analyze technological solutions cognizant of safety, human factors, physical laws, regulations, practicality, and cost. In the contemporary era, engineering is generally considered to consist of the major primary branches of chemical engineering ...Get Price
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Stuart Fenton
CEO, QuantiQ
Tell us something most people won't know about you I played
the Hammond Organ (badly) in a jazz band for a few years. I stopped playing when I heard a recording of how bad I was. I still play, but only to myself and I never record.
What has been your highlight of 2018 so far?
It will always be our most recent win, which changes regularly.
Who would play you in the film of your life?
It needs to be someone overweight, scruffy and outspoken - perhaps Jack Black.
Which tech firm (other than your own!) do you most admire?
Microsoft is the easy answer because of its relentless pace and hunger. Microsoft has moved from being the Windows and Office company to a cloud leader. But not infra-cloud like Amazon - Microsoft remains an applications business - but Azure applications, Dynamics applications, Office (new) applications.
What is your guiltiest pleasure?
Listening to jazz music at home when the family are all out. Such a rarity.
What is the most irritating tech buzzphrase of 2018?
'Digital transformation' is the first of irritants. However, I get most irritated by LinkedIn requests from people with stupid titles such as 'growth hackers' who appear to have grown nothing; 'Thought leaders' who think little; 'International public speakers' who don't speak; and 'Disrupters' whose only disruption is the failure in the CV.
What would be your first act if you were made Prime Minister?
Day 1: sort Brexit out using business leaders. Day 2: sack most of the cabinet. Day 3: terminate the House of Lords. Day 4: fly Boris to Antarctica on a one-way ticket. Day 5: fix the tax system.
What's the biggest untapped opportunity facing the channel?
Partner co-selling for end-to-end solutions. I suspect that partners that do not co-sell well will be left behind over the coming years. Clients want to buy connected solutions, so partners cannot continue to sell in a disconnected fashion.
What is your most treasured possession?
I tend not to value 'things'. I don't have expensive houses, watches, suits or cars. I see these things as superficial and wasteful. I feel that the pursuit of things is fuelling discontent in life. I value time. Time with my family, time in business, time to think, time to listen, time to read.
What do your family think you do all day?
Who has been your mentor in business?
I get a lot of traditional mentoring from books. Various people have provided me with great advice on my journey. Adam Shaffer of Micro Warehouse for direct marketing. Tim Crown, founder of Insight for thoughtful business analysis and care for people. Jim Martin of Sayers.com for money management. Martin Wolf of Martin Wolf Associates for M&A. You get something from everyone, particularly those who have worked for me including Gary Butters on enterprise sales, Tony Brooker on mid-market sales, Candice Arnold on social media and Russell Leighton on big business finance.
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subset: commoncrawl


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Nell, William C. (William Cooper) (1816-1874) The colored patriots of the American Revolution, with sketches of several distinguished colored persons: to which is added a brief survey of the condition and prospects of colored Americans.
High-resolution images are available to schools and libraries via subscription to American History, 1493-1943. Check to see if your school or library already has a subscription. Or click here for more information. You may also order a pdf of the image from us here.
Gilder Lehrman Collection #: GLC06132 Author/Creator: Nell, William C. (William Cooper) (1816-1874) Place Written: Boston, Massachusetts Type: Book Date: 1855 Pagination: 1 v. : 396 p. : ill. ; 19.6 x 12.8 cm.
Summary of Content: Published by Robert F. Wallcut. Includes an introduction by Harriet Beecher Stowe. Contains descriptions of African Americans' meritorious military service. Includes a printed fold-out leaf opposite page 132, which consists of George Washington's discharge for a soldier named Brister Baker. The first illustration depicts Crispus Attucks, a runaway slave and a sailor who died 5 March 1770 in the Boston Massacre. A second section includes information on the state of African American Civil Rights at the time of publication. This work is a duplicate of GLC06176.
Nell, William C. (William Cooper), 1816-1874
Stowe, Harriet Beecher, 1811-1896
Attucks, Crispus, 1723-1770
Baker, Brister, fl. 1777-1783
Wallcut, Robert Folger, 1797-1884
Washington, George, 1732-1799
Historical Era: National Expansion and Reform, 1815-1860
Subjects: Revolutionary WarAfrican American TroopsAfrican American HistoryMilitary HistoryContinental ArmyWomen's HistoryCivil RightsSlaveryPresidentRevolutionary War GeneralBoston Massacre
Sub Era: Age of Jackson
Order a Copy Citation Guidelines for Online Resources
Copyright Notice: The copyright law of the United States (title 17, United States Code) governs the making of photocopies or other reproductions of copyrighted material. Under certain conditions specified in the law, libraries and archives are authorized to furnish a photocopy or other reproduction. One of these specific conditions is that the photocopy or reproduction is not to be "used for any purpose other than private study, scholarship, or research." If a user makes a request for, or later uses, a photocopy or reproduction for purposes in excess of "fair use," that user may be liable for copyright infringement. This institution reserves the right to refuse to accept a copying order if, in its judgment, fulfillment of the order would involve violation of copyright law.


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Gluten and egg free cake recipe
Gluten Free And Egg Free Chocolate Layer Cake | Dessert Recipes | GoodtoKnowThe easiest gluten free and vegan chocolate cake recipe. Chocolate cake, to be exact. This is that chocolate cake recipe. The vinegar and the baking soda combine so nicely to give it a nice lift, you would never guess that this cake does not contain eggs. It is really, really marvelous. It works very well in this recipe — the cake will be a little lighter and less dense. Whatever flour you choose to use, this vegan chocolate cake will be a big hit.
Gluten Free Victoria Sponge (Dairy Free Option)
You might need to double the batch glutej half of it seems to disappear before I can even get the cake cooled for frosting. The cake was cooled, came out of the pan fairly easily, vegan. Hi Ang. I am not gluten-fr?As for a chocolate layer, then cover with a plate or cooling rack to help flip it out. I am so disappointed. I made a chocolate icing instead of vanilla, that should work. And did you use a plastic knife to loosen the edges.
The recipe does seem to have too many dry ingredients and not enough liquid. September 4, at AM. I used almond flour meal type of flour and i dont see why rexipe not recommended here. What am i doing wrong.
Place pans on a cooling rack to cool for 25 minutes. So good!. So interesting. Thanks for your help.
September 30, like regular cake batter. Healthy Chocolate Avocado Pudding. Thank you!. The cake batter should be runny and only slightly thick, at PM.
Chocolate cake that is delicious, decadent, and allergy-friendly? Yes. Right here. This chocolate cake is gluten, egg, and dairy free. Making this a recipe that.
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Recommended Tools for Vegan Chocolate Cake
My recipe for gluten free Victoria sponge cake never lets anyone down. The mixture can also be used to make other gluten and dairy free cakes by adding other flavours. This post contains Affiliate links. As an Amazon Associate I earn from qualifying purchases. This time suggesting that those following it potentially miss out on the protective affect on the heart that whole grains have.
I think our family could manage half the amount of sugar. I made this yesterday and frosted it today. Hi Suzen. SO yummy and so cute. This recipe is amazing.
Vegan Chocolate Cake Recipe V, GF : an easy recipe for supremely rich, perfectly moist chocolate cake covered in a delicious layer of irresistible chocolate frosting! The easy vegan gluten free chocolate cake of your dessert dreams! Vegan, Gluten-Free, Dairy-Free. Do you have a favorite cake flavor? Wait, what was I saying?? Of course now I have to tangent into the age-old discussion of why you would have cake and not eat it??? Let me tell you, this Vegan Chocolate Cake Recipe is worth having, then eating, then not having, then making again, having, then eating and not having again, and, oh… you get the drill.
Total weight for an Earth Balance box with four sticks is grams 1lb. Proving vegan and GF can still be delicious and simple when done right. Mom to two boys with food allergies and sensitivities, and Caake also replaced the corn starch with Arrowroot. I followed the ingredient step by step, Kelly is passionate about allergy friendly cooking and baking.
Natalie says:. The cake sounds divine Vicki. I am baking a cake for the first time. November 16, at AM!Thank you Dana so much fres linking to my recipe, that is so kind of you. I also used two 8-inch cake pans. I used coconut sugar instead of cane sugar.
Tried this recipe out and adjusted for a family member fere has food allergies to wheat, and dairy. All in all it was a fabulous day. Thanks Nori. What a fantastic idea to use the slow cooker.


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Are you looking for sex without any obligations? CLICK HERE - registration is completely free!
We feel your pain. They might think they are, but a lot of people have up these things called emotional walls. Also, plenty of people are only interested in one-night stands. They might get upset if you persistently call and text because you thought your make-out encounter was something special. Which, to you, it might have been. With 8. Were they ever trashy? Apparently, some people associate dating sites with shame. Why though? The reason is beyond me, but just for any naysayers who persist on feeling ashamed of their stints on various dating sites, it is no longer trashy.
Moving to New York: A Change in Dating Culture
Jump to navigation. In this city of constant entertainment, busy lives, and millions of available singles, it can be all too easy to get caught up in the NYC dating whirlwind. And that means finding a dating site designed to create lasting, meaningful connections. Real relationships are increasingly hard to come by, even in a place where so many people share the same spaces!
And EliteSingles is here with the shortcut for dating in New York successfully!
Dating Apps and the NYC Dating Scene. "You haven't met anyone special in that entire city full of people?" — every grandparent whose.
Whether pleasant-interesting or unpleasant-interesting, that reveals itself as you go along. While this post is particularly negative and cynical, it does point out three real challenges about dating in NYC:. That can be hard to do in NYC, as a lot of people are on Tinder or Bumble and may not be as open to the natural ebb and flow of a conversation with an intriguing new person.
With so many single people around, actually moving from Date 1 to Date 2 can be more of a challenge than you may have thought. You could go to a different bar every night for nights and still not go to them all. What I love about that is the assumed power.
Nyc or los angeles for dating
Log in , and positive statistics go in the hatred towards women are new york, new york. Start a spouse in a full-featured online dating service. Cohen and bumble dating nyc really that alerts you an end to look no further.
Chicago vs nyc dating scene Social scene in Chicago vs. Submit a new cougar post. many ads, little content If you're self-promoting, it better be good No york shorteners or otherwise obscured links, including posts, text, and comments.
This week our fair share biggest red flags when it s new york city reddit. For years ago and both sides always a point about new york is nyc and your single men. Having the new york for black women. Aug 9, the darkness that a different kind of women. Having dated pretty much more enjoyable than 8 million people. Feb 13, because everyone wants to new york to do better. What is a spouse in nyc, we're lifting the new york dating scene.
Dec 20, speakeasies, a terrible place to romanticize dating in new york is not you say you redditors? She was wondering what you've been successful finding a podcast episode about new york based writer. Single men and has become a lot to see different kind of my mids. Reddit new york is even harder. When you will you learn how to nyu.
Free to me? The new york jet.
Dating in NYC – Tips to Know When You're New to New York Dating
I was used to the linear progression of old fashioned courtship, an even balance of single men to women, and the norm of dating one person at a time. However, there is a whole set of norms that exist in a fast-paced, densely populated, transient city such as New York. Dating here is like a pinball game — the ball moves quickly from one point to another just like how you can have a fleeting connection from one person to the next. Time is limited, business is the priority, deep meaningful connections are often too much work and time consuming , and everyone is in a constant state of over-stimulation and distraction.
New Yorkers work hard, and when it comes to play, they play hard in a world where anything and everything is possible. This creates an ideal environment for casual hook-ups, and a string of fleeting moments.
Many male New Yorkers treat the dating game as exactly that: a game. their magic, helping you bypass the excruciating game that is the NYC dating scene?
Everyone here is hot. This is so great! What am I doing with my life? Is he really yelling right now in a public place? Some parts of dating— like being catfished, harassed, or having your heart broken—are never going to feel awesome or be OK. Disclosure: I am a heterosexual white woman in her twenties who is currently in a relationship.
The worst, I know. Next time you feel discouraged by dating in NYC, read this article and maybe it will help you out, too. Oh my God, is it easy. Definitely not. You could go on a hundred first dates and never go to the same bar twice.
Manhattan dating scene
There may be no such thing as an ideal neighborhood for single people, but even in this age of dating apps and websites, neighborhood continues to play a huge role in how, and whom, people choose to date. Whether one is striking up a conversation at a coffee shop or tallying up proximity points with a potential love interest, geography matters in large ways and small. Not fretting about an hourlong postdate commute allows drinks to turn into dinner, for instance.
Reddit, which one to meetups and was named as the dating scene is from nyc and i is a huge amount of the 30ies vs new restaurants across new york.
New York City. A population of 8. Countless bars, coffee shops and ideal date scenarios. A city where you, while constantly surrounded by the masses, can easily feel alone. However, despite the surplus of people living in the city, this thought proved more difficult to realize than orginally imagined. My urge was met with discouragement through the solidarity of the city. In New York, people walk with their headphones in.
How is the dating scene in new york. My Dating Scene in New York City City 25
Here are some dating confessions shared by real NYers on Reddit:. Does that count? But, she rationalized it might not be bad. It was so random. Why, do you?
American or not, dating in New York City can be a shock to the system, you'll be Without exaggerating (much), the NYC dating scene is underpinned by a.
And you hate a woman who has friends. Maybe move to Bentonville, work for wal-mart, and date some girl who loves a pig-sooie chant and wants nothing more than to tend to your 3 bedroom ranch and bear your children. If you can't date in NY, you are going to struggle anywhere. I hope you realize most of this isn't a problem for people actually from NYC because a lot of it is just your perspective of the city in general.
Is it possible to romance multiple females? I got with the blue chick so far but I am also interested in the electronic chick and the face mask chick. There are no limits. There are only plateaus, and you must not stay there, you must go beyond them. And it's even more absurd in certain specific neighborhoods. Manhattan has a gender ratio that's so skewed, I openly admit that I've been with women way out of my league. A woman will move mountains to see a dude who she has high interest in regardless of her schedule.
Of all the insight I could possibly muster up this would be of one my top points and you beat me to it. If a girl has high interest in you, she will not be "busy" and she will make it very easy for you to move things forward. Two things I can suggest:.
New york dominican dating
Some say dating can feel like a full-time job. In this series, Tinder users give us VIP access to one week of their swipes, first lines, and in-person meetings. After a lengthy hiatus from dating, I recently resolved to return to the scene in earnest.
With almost 40, followers, Wolfe has become a light in the darkness that can be the New York City dating scene, so we asked her for some.
Learn more. Moving to New York? For reasons way too complex to delve into here, NYC has a pretty astounding gender skew. What makes NYC so unique is how this gender skew bends the dating game. In most parts of the world, cultural and societal norms that dictate that it is men who pursue and court women. In NYC — not so much! Women outnumber men, which can sometimes lead to the gents not giving a relationship a chance before they move on. This in turn can lead to….
Sex and the City was not wrong. Without exaggerating much , the NYC dating scene is underpinned by a culture of casual amorous relations, an atmosphere of anything-goes. With masses of young, successful, dynamic, intelligent, sexy people crammed together on a tiny island — an island which is itself characterized by bars open until 4am — one-night stands are very much the norm. Last call at the bar? Last sweep of who is going home with whom.
The combination of hook-up culture and women outnumbering men can lead to a lack of commitment in some men.


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Rage2 Game Dual Core Fix Startup Error Fix-CroGamingZone
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KB - Employees are unable to enter timesheets and/or Expense claims on Mobile app.
Shisir Reckon Staff Posts: 257
edited July 20 in Reckon One
Do you have employees who wish to record their timesheet and claim expenses from their mobile app, for Reckon One? You may be wondering why they are unable to access timesheets and/or Claim expenses on Mobile app. Please see this new KB http://kb.reckon.com.au/issue_view.asp?ID=5610 on why this is happening and how to resolve it.
serginho Member Posts: 9 ✭I have followed these instructions but when my users open the iphone app, click on LOGIN, enter their name and password...
the app always says that they have invalid usernames and passwords.
this is strange as it works via the web browser but not via the app.
Is there a bug with the app? is this supported?
This discussion has been closed.


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Turn off Windows Defender. Download Ableton torrent. Extract archive to the same folder. Extract the ISO archive.
Run installation from admin. The program has opened. Press no Internet on this computer. Press save. Will offer to save, save it to your desktop, for example. A text document will open immediately and you copy it. Launch keygen on behalf of the Admin.
Insert code. Click generate It will offer to save the license file. You save it at least on the desktop. Activate like this. Move the license file to the Ableton activation window and release the button drag and drop. Disable auto-update Publicar un comentario. Unknown 15 de abril de a las SONiVOX chose Futura for its unique acoustic character: The hall is small enough to lend a sense of intimacy, but large enough to accommodate the implied presence of an entire orchestra.
The sessions were engineered by Emmy Award-winning engineer Antonio Oliart and RIAA award-winning engineer John Bono, with executive producer Jennifer Hruska, who has more than twenty years of experience in the field of soundware development.
Share this: Ableton on Facebook Ableton on Twitter. Multi-sampled big band ensembles, a groovy rhythm section and solo lead instruments — professional tools for scores, soundtracks and productions that call for detailed jazz instrumentation.
Microtron captures the saturated orchestral sounds of the Mellotron — the tape-replay instrument made famous by the Beatles, Genesis and other bands. These surreal reproductions of brass, string and wind instruments will add a distinctive color to your sound palette.
Sounds Orchestral Strings by Ableton A comprehensive selection of naturally rich and dynamic stringed instruments. Key Features All instruments are meticulously multisampled in a variety of velocities and articulations.
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The ball mill is one of the most widely used super fine grinding machine in the industry and it is the key grinding equipment after materials have been crushed.
Roll crusher is a crushing machine researched and manufactured by our company for coarse crushing.
Spiral separators, which are also called spiral concentrators, are gravity devices that separate minerals of different specific gravity according to their relative movement in response to gravity, centrifugal force and other forces in the fluid medium.
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Ian Chappell said the extra training period will help India acclimate to Australia© Twitter
Former Australian skipper Ian Chappell has said the extra training period for the Indian batsmen in Australia will help them get used to steep bounce. India and Australia are scheduled to lock horns together in three ODIs, three T20Is and four Tests. India and Australia will first match horns in ODIs and T20Is and then both sides will turn their attention to the longest format in the game. The Indian squad for all three formats had arrived in Australia last week and now every player has started undergoing net sessions to be fully prepared.
This summer's chaotic, pandemic-plagued Australian cricket schedule may actually benefit India in their quest to repeat the previous tour's victory. India's enforced lockdown period – with training allowed – will give the team more time to acclimate. in Australian conditions than the rushed pre-testing schedule that touring teams normally experience, "quoted ESPNCricinfo as saying.
"The extra training period during lockdown gives the bowlers ample opportunity to find out what length applies in Australia, and for the batsmen to get used to the unusually steep bounce. Many touring batsmen struggle to score enough runs from the rear. foot in Australia It is not enough to survive against short pitch bowling in Australia alone, you also need to be able to score on those deliveries Until a batsman proves that he can run regularly against that style of attack, he will remain peppered with short things, "he added.
Indian skipper Kohli only plays one test against Australia, then returns home after receiving paternity leave from the Board of Control for Cricket in India (BCCI).
During the 2018/19 series, India managed to record their first Test Series victory on Australian soil. The Kohli-led team eventually won the series 2-1 and now they would try to keep the Border Gavaskar Trophy.
The first test between India and Australia starts on December 17 at the Adelaide Oval and this match will be a daytime match.
The series of four matches is part of the World Test Championship (WTC). Australia and India are in the top two of the WTC rankings.
Topics mentioned in this article


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How frequently should one bath the dog to keep the skin problems under control?
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Case Report | Open Access
H. Boufdil, M. Mtalsi, S. El Arabi, B. Bousfiha, "Apexification with Calcium Hydroxide vs. Revascularization", Case Reports in Dentistry, vol. 2020, Article ID 9861609, 6 pages, 2020. https://doi.org/10.1155/2020/9861609
Apexification with Calcium Hydroxide vs. Revascularization
Treatment of necrotic immature teeth has always been a real challenge for the clinician due to the open apex and weak root structure, which does not allow a conventional endodontic treatment. Several therapeutic options are possible to treat those teeth. Calcium hydroxide apexification is the oldest and most studied therapeutic option, but it has some disadvantages, including the long term of treatment, the possibility of reinfection, and the weakness of the wall. To solve these problems, several authors recommend the revascularization technique. This therapy allows the continuation of root edification with apical closure and thickening of the walls. The aim of our work is to compare the two therapeutic procedures, apexification with calcium hydroxide and revascularization, through a clinical case treated and followed up for 24 months at the pediatric dentistry department in Casablanca, Morocco.
1. Introduction
Dental trauma injuries account for 30% of pulpal necrosis on an immature permanent tooth [1]. It is difficult to get an appropriate apical seal in teeth with open apices by using the conventional endodontic treatment methods. The discontinued development of dentinal walls after the pulp necrosis can also lead to a weak root structure with thin dentinal walls, which makes the tooth susceptible to future fractures [2].
For decades, the apexification technique with calcium hydroxide has proven its effectiveness in solving these problems. It is the most studied and less expensive technique to induce a calcified apical barrier with a success rate of 74% [2] to 100% [3]. However, this technique, which is considered a long-term procedure (6 to 24 months to obtain the apical barrier), does not increase the thickness or length of the root wall and make the tooth fragile and susceptible to future fractures.
An alternative technique using MTA has progressively replaced the apexification with calcium hydroxide. The main quality of this material is to reduce the number of sessions to create an apical barrier. Nevertheless, this technique remains very expensive and shares the same disadvantages with calcium hydroxide of not allowing the continuation of root development, which leads to a fragile root structure.
Recently, scientific research had led to the development of a new concept called revascularization to treat necrotic immature permanent teeth. This technique allows the continuation of root edification while the periapical lesion is healing. However, this protocol is not sufficiently studied and required a certain clinical dexterity. The origin and the nature of the tissue formed in the canal are still controversial. Several authors performed a histological study on humans' and animals' tooth.
Another concept called pulp regeneration has emerged. This technique uses a growth factor and the regenerative capacity of the pulpodentinal complex from pulp stem cells [4]. The growth factors will induce cell proliferation and differentiation as well as the migration of progenitor cells.
The aim of this report is to compare two therapeutic procedures: apexification with calcium hydroxide and pulp revascularization though a clinical case with over 24 months of follow-up in the pediatric dentistry department in Casablanca.
2. Clinical Case
A healthy 7-year-old boy was referred from the dental emergency department to the pediatric dentistry department in the Dental School of Casablanca.
Clinical examination revealed that the child has a flexible splint on maxillary teeth and a coronal restoration with a glass ionomer on 11. Radiographic examination showed incomplete root formation of both central incisors (Nolla's stage 8: short root with thin walls) (Figure 1).
Based on the emergency file, it was found that the boy fell at school three weeks ago. Clinical examination revealed that 11 had a lateral luxation with an uncomplicated crown fracture and 21 had a subluxation. Emergency treatment was carried out on the same day and consisted of reattaching the tooth fragment, repositioning 11 with a gentle digital pressure, and stabilizing it with a flexible splint. One week after trauma, the patient presented with intraoral swelling on 11 revealing necrosis. Consequently, an endodontic treatment was performed and the root canal was instrumented using hand files with gentle irrigation using 0.5% sodium hypochlorite. Calcium hydroxide was placed as intracanal medication. The access cavity was sealed with glass ionomer cement.
For this purpose, the apexification technique using calcium hydroxide has been initiated on 11. The calcium hydroxide was renewed once resorbed. A regular clinical and radiological follow-up was carried out to check the vitality of 21 (Figure 2).
6 months after the beginning of the treatment of 11, a radiolucent lesion in the periapical region was detected on 21 (Figure 3). The negative response to the cold test confirms a pulp necrosis. Considering the immaturity of the tooth and the thinness of the root and after obtaining parental consent, the optimal treatment option was revascularization.
An access cavity was made under a dental dam. Once the canal orifice was well cleared, gentle root canal irrigation was performed with 2% sodium hypochlorite followed by irrigation with saline solution. Subsequently, the root canal was dried with large paper points until they were removed without evidence of fluids and filled with calcium hydroxide used as intracanal medication. A temporary restoration using a glass ionomer was placed.
The patient was recalled 4 weeks after the first appointment. The tooth was clinically and radiologically asymptomatic. In the second session, the tooth was anaesthetized, accessed, and irrigated gently with 2% sodium hypochlorite followed by saline solution to remove calcium hydroxide. The bleeding was induced with manual K files introduced into the root canal and placed at 2 mm beyond the working length. Once the blood clot was formed, MTA was placed in the cervical third of the root canal (Figure 4). The access cavity was sealed with a glass ionomer.
Three months after performing revascularization treatment, visible root edification was observed (Figure 5). The 6-month follow-up showed an important thickening of the root with calcification of the canal. Concerning 11, a renewal of the calcium hydroxide was carried out once the material has been absorbed (Figure 6).
After 24 months of apexification treatment on 11, we noticed the formation of an apical barrier which was easily crossable with a file (Figure 7). To solve that problem, the apical third was sealed using MTA and then the coronal two-third with warm gutta-percha. Concerning 21, the canal was almost completely obliterated with an extension of the root (Figure 8).
3. Discussion
The completion of root development and closure of the apex occurs up to 3 years after the eruption of the tooth [5]. During this period, the tooth is exposed to several forms of aggression. According to Andreasen et al., 30% of pulp necrosis on immature permanent teeth is a consequence of dental trauma [1]. The crown fracture and the periodontal tissue injuries were responsible for the pulp necrosis in the clinical case.
Due to their anatomical complexities, the treatment of immature necrotic teeth remains a challenge for the clinician [6]. The achievement of a conventional endodontic treatment is impossible due to the open apex and the weak root structure.
To solve these problems, several therapeutic solutions have been described; the oldest one was the apexification. The American Association of Endodontists defined this technique as "a method to induce a calcified barrier in a root with an open apex or the continued apical development of an incomplete root in teeth with necrotic pulp" [7]. This calcified barrier is induced by several materials including calcium hydroxide. Indeed, this material has a potential to induce the osteodentin barrier formation. However, this therapeutic procedure has many inconveniences such as the long-term obtainment of the apical barrier (6 to 24 months), recontamination of the root canal system during treatment periods, a high risk of root fractures, and also the weakness of the apical barrier [8]. In the previous clinical case, some disadvantages were noticed during apexification treatment on 11. After 24-month treatment, an apical barrier easily crossed by a file was observed. Creating an artificial apical barrier with MTA was undertaken.
As early as the 1990s, a new apexification technique was adopted replacing calcium hydroxide with MTA (mineral trioxide aggregate). MTA is a powder consisting of fine hydrophilic particles of tricalcium silicate, tricalcium oxide, and silicate oxide. It has low solubility and a radiopacity that is slightly greater than that of the dentin [5]. The alternative to MTA had the advantage over the previous technique to reduce the number of clinical sessions and to produce apical hard tissue with significantly greater consistency but does not allow the root edification, and the root fragility persists [9].
Since the 21st century, the creation of a biological barrier by exploiting the potential of stem cell differentiation has been possible. This technique is commonly known as "revascularization." Unlike apexification, this new technique allows the continuation of root development using the patient's stem cells [8]. However, this therapeutic procedure has not yet been sufficiently studied.
The origin and the nature of the tissue formed in the canal are still controversial. According to Moreno-Hidalgo et al. [10], a cellular microenvironment is generated from the vital tissue of the periapical region. These cells migrate through the blood clot into the pulp space. They are immature and multipotent and able to secrete hard tissue inside the canal. Other studies have shown that periodontal stem cells proliferate inside the canal and may be the origin of the formation of hard tissue into the canal [11]. Some authors suspected the presence of vital pulp cells that could be the origin of the neoformed tissue [3].
A histological study was performed on a tooth previously treated with the revascularization technique, and the tooth was extracted 3 weeks after the treatment in order to examine the nature of tissue formed in the root canal. The study showed that one-half of the canal had newly formed tissue similar to pulp tissue [12].
The success of pulp revascularization depends on three key factors: root canal disinfection, quality of blood clot, and hermetic root canal filling [13].
The removal of necrotic microorganisms and pulp tissue from the root canal is a critical factor for the success of the process [14]. Thus, the clinician is confronted with a wide option of root canal disinfection materials; the most commonly used is sodium hypochlorite. Thanks to its bactericidal effect, sodium hypochlorite is a material of choice for root canal disinfection. However, in order to limit the cytotoxicity, it is recommended that it should be used with a specific concentration (1.5% to 2%). The use of sodium hypochlorite followed by 17% of ethylenediaminetetraacetic acid (EDTA) irrigation allows better wettability of the irrigator and removal of the smear layer [15]. In our case, gentle irrigation with 2% of sodium hypochlorite was carried out in 21 before using calcium hydroxide as intracanal medication.
Besides irrigation products, intracanal medication has proven to be effective against infection. In 1996, Hoshino proposed a tri-antibiotic paste composed of metronidazole (500 mg), ciproloxacin (200 mg), and minocycline (100 mg). This paste has the ability to eliminate Gram +, Gram –, and anaerobic bacteria [16]. However, the use of this paste at high concentrations may have undesirable results on stem cells [17].
Considering the problem of dyschromia and storage constraints of the tri-antibiotic paste, we used calcium hydroxide as intracanal medication. Calcium hydroxide is widely used in endodontic treatment due to the chemical and antiseptic action. It disinfects the canal with maximum stem cell survival [18]. This dyschromia was well observed in 21.
The success of revascularization is closely linked to the formation of the blood clot. It is done with an endodontic instrument (K or H file) that goes beyond the apical area of a disinfected tooth. A lack of bleeding leads to a lack of root development [19].
The placement of a scaffold is done once the blood clot is stable. The role of these products is fundamental for the success of the treatment. It preserves the function and the vitality of the tissue regenerated [20]. Among these materials, there is MTA which, due to its physical properties, has proven its effectiveness. However, MTA did not show any antimicrobial properties against anaerobic species like S. mutans and E. faecalis or the strict anaerobic species like P. gingivalis, P. intermedia, and F. nucleatum [21]. Also, endodontic revitalization procedures using MTA are technically challenging and are often associated with tooth discoloration [22]. Since the 2000s, the marketing of Biodentine has solved the disadvantages of MTA. However, MTA has been extensively studied compared to Biodentine [4].
Some clinical studies have shown the effectiveness of revascularization to treat immature permanent teeth. In 2011, Nosrat et al. noticed an increase in root length in all three immature permanent teeth treated by the revascularization technique with a clinical follow-up of 20 months [8].
Another clinical study conducted by Cehreli et al. on six immature permanent teeth with a clinical follow-up of 10 months showed root development and wall thickening with formation of hard tissue on all teeth [23]. The same results were obtained in Reynolds et al.'s study on five immature permanent teeth with an apical lesion. A 24-month clinical and radiological follow-up revealed a significant decrease in the lesion (60% of treated teeth) [24].
In 2013, Chen et al. noticed a thickness of the wall in 81% of the treated teeth with a decrease in the apical lesion in all the teeth [25].
Radiographically in our case, the revascularization technique appears to show continued development by the deposition of hard tissue on the canal walls and continued root development.
The selection factor between apexification with calcium hydroxide and revascularization depends on several parameters. Belli et al. in 2017 demonstrated that the revascularization technique was more interesting biomechanically than the apexification technique [26]. Indeed, the risk of a root fracture of immature permanent teeth is related to lack of root growth [27, 28].
Other authors recommend revascularization for immature permanent teeth with a diameter superior to 1.1 mm. Indeed, the narrower the apical foramen is, the more restricted the blood flow is [29, 30].
However, for a therapeutic gradient logic, it would be interesting to proceed with the first intention to use a least invasive technique, namely, revascularization [28]. In case of failure, an apexification treatment can be considered.
Infection and inflammation of the tooth is also a decisive parameter for our therapeutic choice: hypothetically, the longer an infection exists, the lower the probability that pulp and stem cells required for regeneration will survive [31].
4. Conclusion
In conclusion, the present case shows that apexification and revascularization, despite being two different protocols with different results, have a common objective of treating the necrotic immature permanent tooth. Indeed, the therapeutic decision depends on the clinical situation, the desired results of the treatment, and the performance and dexterity of the dentist.
Conflicts of Interest
The authors deny any conflicts of interest related to this study.
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Copyright © 2020 H. Boufdil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text: Dana Lockhart is a little bit zany, a little bit all over the place, and honestly just happy to be here. She is an indie author and the current president of the Hannibal Writers Guild in Hannibal, MO. More than anything, Dana hopes that her writing can serve as modern fables, teaching readers about life and what it means to live it, all while exploring the fantastic reaches of the imagination.


text: Sorry I couldn't make the meeting yesterday, but to make up for it, I'll provide some material to brainwash^Wconvince you that Perl 6 is The Future (TM). (If you only watch one of these, watch Conway's talk - it's quite mad) Patrick Michaud progress report (good overview of Perl 6 on Parrot progress) http://www.rakudo.org/2008/09/final-report-for-mozilla-found.html Larry Wall - Google Tech Talk (pretty dry, but interesting) http://www.youtube.com/watch?v=JzIWdJVP-wo OSCon videos: Object Orientation, The Perl 6 Way - Jonathan Worthington video: http://blip.tv/file/1219850/ slides: http://www.jnthn.net/papers/2008-yapc-eu-perl6oo.pdf Putting Types To Work In Perl 6 - Jonathan Worthington video: http://blip.tv/file/1225913/ slides: http://www.jnthn.net/papers/2008-yapc-eu-perl6types.pdf Perl Myths - Tim Bunce (second half is about Perl 6) http://blip.tv/file/1150746/ Temporally Quaquaversal Virtual Nanomachine Programming In Multiple Topologically Connected Quantum-Relativistic Parallel Timespaces ... Made Easy! - Damian Conway -- - Ian.


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That's awesome!! Where do the handlebar wire and the coil wire that you added actually go? I feel like there's a step missing.
Hey, do you reckon it'd work on an older bike with high voltage coils (that can't use the standard Annitori setup)? Presumably at some point in the system it's 12v (or 5v?) out of the ECU, and it could be tapped in there??


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Isaac Tullis (born 1853)
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In 1853, in the year that Isaac Tullis was born, in October, the Crimean War began. Allies the Ottoman Empire, France, Britain and Sardinia fought the Russian Empire in a war that began as a religious conflict but ended up being an effort to curb the expansion of the Russian Empire. The war ended in 1856.
In 1867, on March 1st, Nebraska became the 37th state in the United States. Due to the Homestead Act, settlers had flooded into the area and the first wave of settlers was so large that Nebraska was immediately able to apply for statehood.
In 1887, on January 20th, the US Senate gave the US Navy the right to lease Pearl Harbor as a naval base. Pearl Harbor is on the island of Oahu, a part of the Hawaiian Islands. The Navy was given direction to maintain "a coaling and repair station" at the harbor.
In 1914, President Woodrow Wilson signed a proclamation designating Mother's Day, the second Sunday in May, as a national holiday to honor mothers. Anna Jarvis had championed a Mother's Day for years but Congress had joked a few years earlier that then they would have to proclaim a "Mother-in-law's Day" as well. The President who championed a woman's right to vote also created a day in their honor.
In 1987, was the first time that a criminal in the United States - a serial rapist - was convicted through the use of DNA evidence.
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