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The Supreme Court upheld the constitutionality of such commitments in Kansas v. Managing High Risk Offenders in the Community. Quasi-criminal commitments. LouisianaU. A police officer is often the individual who decides whether a rule-breaker should be taken to a hospital or a jail. Many capital sentencing statutes explicitly mention mental abnormality as a mitigating condition and some even use the language of the insanity defense or the extreme emotional disturbance doctrine as the mitigation standard.
Almost certainly, the same considerations that apply to incompetence to stand trial commitments would apply in this context.
The same person may be viewed as primarily in need of mental health care and diverted from the criminal justice system. Important caveat for practitioners: Addressing mental health needs should not be the only intervention goal. It is not always the case, for example, that disordered persons are not responsible for their behavior.
Although incompetence proceedings affect a greater number of mentally disordered offenders, the insanity defense has claimed most of the attention devoted to offenders with mental disorder.
Automatic orders on conviction for sexual offences Additional note: Availability of ancillary orders. A restriction order section 41 may be imposed by the Crown Court where a hospital order has been made and:. There are commonly also directly related emotional problems, as the brain can no longer control emotions, and also secondary emotional problems when the sufferer retains insight and is aware of progressively losing his or her mental abilities.
Assessment of financial circumstances 5. Forfeiture and destruction of weapons orders Guardianship order section 37 Mental Health Act
For other helpful reading see: Blanchette, K. Long-term hospitalization is not necessary for moderately disabled persons, and short-term hospitalization usually suffices for the treatment of acute serious disorders.
Search Help. Although incompetence proceedings affect a greater number of mentally disordered offenders, the insanity defense has claimed most of the attention devoted to offenders with mental disorder. With proper medication and management, most disordered defendants can be restored to competence within a matter of months.
On the other hand, a vigorous dissent by four Justices seemed to suggest that although the acquittee had been found non-responsible, a post-insanity acquittal commitment was a genuinely criminal commitment because the state was able to prove that the defendant committed the crime.


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- Home
- Web page design
- Web page design contests
- Modern & luxurious equestrian center searching for a fresh website to better reflect our facility
Horsebacklessons got their new web page design by running a design contest:
Modern & luxurious equestrian center searching for a fresh website to better reflect our facility
Check out Horsebacklessons's Web page design contest…
The Brief
Animal & Pet
About us
Western horseback riding lessons, adding in an English riding program this Fall and wanting an updated website to reflect this addition. Target audience is families with children..
Existing website
The Brief
Style/theme ideas
More modern and elegant design, A more Upscale and luxurious feel To the website. Will need some stock photos, but have quite a few to draw from that include our horses, instructors, and facility. I have all of the content, just needing help with a new template and possibly pictures, too.
Silver package
Every design category has flexible pricing for all budgets. Web page design starts at €549.
File deliverables
Full copyright with production-ready files for digital and/or print.
It all began with a design brief.
A quick, interactive guide helped them understand their design style and captured exactly what they needed in their web page design.
Designers across the globe delivered design magic.
design entries
You'll get loads of concepts from experienced designers around the globe.
Work with talented, professional Web page design designers to turn your ideas into reality.
Select your favorite custom Web page design (Or two! Or three!). And the design is all yours.
Horsebacklessons collaborated with designers to refine their ideas
Rate designs
When design entries come in, you can rate them so designers know what you're looking for in your logo design.
Give feedback
99designs has great collaboration tools so you can pinpoint and capture your ideas
And then… they selected a winner!
Along the way, they met lots of talented designers…
We think contests are a super fun way to get design.
Recently completed contests:
Contest for logo creation of a new B2C premium plush animal product
Pet Twins is a company that handcrafts real pets in plush form (please see attachment). With love! Our plush twins of re
Creation of a personalized logo for a equine-therapist / Un logo pour une équithérapeute
I'm a psychologist and I provide equine-assisted therapy. It's a form of psychotherapy that incorporates horses into the
Logo design needed for tripod dog supplement company
Phoebe is an all natural dog supplement & supply company. The company is named after our three legged rescue dog, Ph
Logo for a FUN and GROOVY animal education brand
**Important** There must be a Monkey! This is about a MONKEY who seeks to understand Animals! We focus on exploring an
Design a futuristic design and layout for a pet id tag.
Pet ID Tags, helps pet finders contact lost pets owner. We are planning to retail the product in stores
Logo Design for an Onlineshop with dog accessories and supplies in Switzerland
We sell dog accessories and dog supplies that are selected, tested and recommended by dog trainers. We have experience a
French Bulldog Logo Needed :)
We breed and sell French Bulldogs. TC is short for the owner's name, Tony Cooksey.
Bold animal feed logo to take on a nationwide advertising and sales campaign, both for online and retail pet food stores
We grow, package, and sell Alfalfa hay, Timothy hay, Alfalfa pellets, and Timothy pellets to small pet owners of rabbits
Premier Equestrian Training Logo Design located in the PNW
We are a premier dressage training and breeding program, located in the PNW. The target audience is usually female, with
Design a hip logo for a dog accessories manufactory
We are based in Augsburg (bavaria), Germany. We produce high quality, custom leashes, collars, accessories and merchandi
Subscription box homepage - DoggieBag
DoggieBag is a subscription service for dogs and dog owners. It is a monthly surprise box, filled with 5-6 items for the
Create a modern website for my groundbreaking vet app
You will be designing the homepage/landing page for a webapp allowing vets to perform online consultations via video upl

subset: commoncrawl


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A.C.E. delivers solution focussed interventions to suit the needs of individuals or groups. Our trained and experienced workers use discussions, games, art and craft, drama and role play, to increase resilience and improve emotional and mental health and wellbeing.
This service is currently available for young people aged 11 -25 in the Lancaster, Morecambe, Carnforth, Kirkham and Fleetwood and takes place in schools, GP surgeries and community settings.
We are seeking fund to extend the service to other areas and to children and adults.
Young people referred to the service are offered either individual support or group work to tackle the causes of poor emotional health and wellbeing and are encouraged to set goals to overcome them and build resiliance.
Our services include the following
A.C.E. works with young people that are suffering from anxiety or stress, are or have been bullied, are having difficulty coping with their emotions, have been involved in a domestic, violent situation,
have difficult family situations, have friendship difficulties, have relationship difficulties, have low mood or have low self esteem or confidence.
A.C.E. also works with parents/carers and families to improve emotional health where appropriate.
Individual support uses a variety of solution focused methods to encourage the young person or adult to identify and tackle the causes of poor emotional health and wellbeing and set goals to overcome them and build resilience.
Young people identify being listened to and challenged to think differently. It is not only a pleasant experience but motivates them to change things in their attitude and behaviour which improves their well being and builds resilience.
Positive emotional health and wellbeing supports general health and achievement in life. Evidence shows that focusing on supporting emotional and social development can have a positive long term impact. We have evidence that our work makes a positive difference to the lives of the young people we work with by:
This results in better school attendance and achievement, better support network and more friends, improved family relationships, a reduction or ceasing of self harming behaviours and a more active lifestyle and community involvement
We are:
Our Staff & Volunteer Workers
You can view more details about the background and experience of our Staff, Volunteers and Directors on the Team Members Page here
As a small charity we are always looking for new Trustees to get involved and support our work. We are currently looking for volunteers with the following skills: strategic business planning, financial management, marketing, ICT/social media, fundraising/bid writing and administration.
We are also always looking for volunteer fundraisers and people to help deliver the service. Please visit our volunteer information page here for more details
Please feel free to contact us using the form here to find out more about how you can get involved.
My emotional health has improved greatly since starting. I feel like a completely different person now and can'r believe how differently I handle situations. I really liked the relaxed setting because it allowed me to speak freely about anything without feeling judged or rushed
The strategies and having someone to open up to took a lot of the worry and upset off my chest. Increased resilience and confidence when faced with a hard situation enabled me to feel better about myself and identify the qualities I have as a friend and as a person. I am a lot happier, I am able to help others and give something back. Thank you for all the help-so amazing. I definitely recommend
A-C-E are very easy to talk to which allowed our daughter to open up about her feelings and worries. Setting her tasks each week gave her motivation to overcome situations. She is a different girl which is lovely to see.
Very professional service with quick turn around between referral and initial assessment. Excellent at arranging appointments and information sharing whilst maintaining confidentiality. The service provided has been brilliant which has led us to submit more referrals to support our young people's improvement in emotional health and well being. Thank you for your continued support. We would like more of your service
We have been successful in securing funding from the Westminster Foundation for a family worker to join the Ace team . This will enable us to work more comprehensively with young people AND their families , where it is difficult to help improve the young person's emotional health without family input . Thank you Westminster Foundation …
Ace wishes to extend its best wishes to the family and friends of Gill Murphy who sadly passed away recently . Gill was doing some admin work with Ace and will be missed from our office to which she bought humour and goodwill. Many thanks to those who attended the celebration of her life where £230 was …
Our Summer 2020 Newletter is now available on line via our Newletter page or you can access using the following link Summer 2020 Newsletter
This is Mental Health Week and we at A-C-E are focusing on Men and Their Mental Wellbeing. Did you know that: In England, around 1 in 8 men have a common mental health problem*. However, men may be reluctant to seek support for their mental health or disclose mental health problems to loved ones. While …
National Growing for Wellbeing Week 2020 Emotional Wellbeing is an important part of life. There are many different ways that we can support ourselves and others to find a helpful balance. One of those ways is to get out in the garden and grow plants, flowers or vegetables. There are many benefits: Improve mental health …
Here we are 'STAYING ALERT!' and (yes still) in 'Lockdown' with all the stressors that this can bring! It may help us if we remind ourselves that it's Mental Health Awareness Week – 18-24th and we'd like to introduce you to 'Compassion Focus Therapy' which is a proven evidence based therapeutic approach that includes some …
The effects of Grief and Bereavement can have a considerable effect on our lives – particularly in these challenging times. These effects can sometimes be prolonged and Traumatic for us and be categorised as 'Complicated Grief'. Losing a loved one is one of the most distressing and, unfortunately, common experiences people face. Most people experiencing …
Teenage & Younger Mums/Parents can experience mental health challenges associated with pregnancy, birth & parenting. 'Baby Blues' – this can happen 2-3 weeks after the birth & generally go away after 2-3 weeks. Symptoms can be mood swings, tearfulness, anxiety, sadness, things feel too much, hard to fall asleep, low concentration. Depression – this can …
April was Stress Awareness Month and here is what we did as part of our contribution As part of April Stress Awareness Month we are including regular features to aid those struggling at this unpresidented time we have a six and a half minute video that includes a brief mindful breathing exercise from one of …
Facts: Stress is a usual part of being human. It is a reaction that affects everyone. At times it can be helpful as it can motivate us. Stress can affect not only our emotional-wellbeing but also our physical-wellbeing. When a situation becomes overwhelming our bodies respond. The fight/flight or freeze response occurs. Each person will …
W.O.Street Transformation Fund
e-mail: email@example.com
Tel: 07717316883 or 07468600903
18 Sun Street
Copyright 2019: Achieve Change & Engagement. ALL RIGHTS RESERVED


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Lady Luck ... again!
On the way home from photographing the massive offshore windfarm support operation in Lowestoft I was idly pointing my camera out of the not-very-clean train window when this small group of land based turbines came in sight.
I grabbed a shot just in case it might be worth printing, unaware that my kind neighbour who arranged the trip and came along to help me on and off the train had secretly snapped me with her 'phone . . . until an email with the unexpected image arrived two days later. Never able to resist a gift opportunity I stuck the two pictures together.
My extra today: The orignal images, which were merged manually using the clone tool in iPiccy.com
Lady Luck had again come to my rescue, adding to the pleasures of an already successful day, and as there are two photos here by different photographers I felt compelled to give the combined image a double copyright tag.
Thank you Jan, for your great support!
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The lenox hotel 410 feet northwest. Copley square hotel hotel.
Copley Square Park In Boston Ma Concerts Tickets Map Directions
Downtown crossing neighborhood 1 mile northeast.
Copley square boston map
. Copley square copley square is a park in massachusetts and has an elevation of 13 feet. 50 reviews 617 266 2664 website. In the area localities. View an interactive 3d center map for copley place that provides point to point directions along with an offline mall map.
Menu reservations make reservations. Map of copley square hotel boston. Copley square is situated in back bay close to the westin copley place. Order online tickets tickets see availability directions.
Beacon hill suburb 1 mile northeast. Locate boston hotels for copley square hotel based on popularity price or availability and see tripadvisor reviews photos and deals. Get directions reviews and information for copley square in boston ma. Copley place shopping mall 460 feet southeast.
Copley square 560 boylston st boston ma 02116. Boston duck tours tourist attraction 440 feet southwest. Boston hop on hop off trolley tour with 18 stops from us 47 25 downtown freedom trail walking tour plus beacon hill to copley square back bay from us 35 00 copley square to downtown boston freedom trail walking tour from us 35 00. According to tripadvisor travellers these are the best ways to experience copley square.
Leventhal map center library 390 feet north.
Map Of Courtyard By Marriott Boston Copley Square Boston
Directions To Old South Church
The City Record And Boston News Letter Boston Maps
How To Get To Copley Square In Boston By Subway Bus Or Train Moovit
Google Map Emerald Necklace Copley Square And Boston Commons
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File Map Copleysq Boston Bacon1903 Png Wikimedia Commons
Copley Square Urban Trekking Boston
Copley Square Once And Future City
Copley Square Boston Map Facts Location Best Time To Visit
Photo Map Of Boston S Back Bay Landmarks


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"In the end we will conserve only what we love; we will love only what we understand; and we will understand only what we are taught." (Baba Dioum, 1968.)
By sharing our knowledge of the great outdoors and how to safely enjoy it, the Outings committee works to help others learn about, understand, and love this beautiful planet we call home. Our Virtual Backpacking School has reached an average of 20 students each week since May 2020. In each session we teach participants different elements of backpacking to help them gain confidence and competence in the backcountry. Throughout each class, we emphasize Leave No Trace principles and teach participants how to be responsible stewards as well as competent outdoors women and men. We know that if we can equip them for a good experience in the backcountry, Mother Nature herself will take over from there, showing them all there is to love out there.
For some, fall is the very best time of the year for backpacking. The cooler, mostly dry weather is perfect for trekking and refilling your cup with all that nature has to offer. So, in September, we switched from a weekly to a twice monthly format to allow our instructors more time to get out in the backcountry in person on their own (encouraging COVID protocols, of course).
In November, we will present our last 2 webinars for 2020, bringing us to a total of 20 webinars for the year: "Trailside Gourmet" on November 5th, and "Backpacker Meals in a Baggie… Crazy?" On November 19th. Join us! You'll find all our topics and registration information here.
Barry Randall showing off his gourmet campfire food.


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Brazilian Waxing
3 venues
Bookwell is an effortless way to access your favourite beauty and wellness businesses in Broadmeadows. Whether you're waiting in line for coffee or otherwise on the go, any time is a good time to get on Bookwell. We're making wellness happen one click at a time.
When you're due for your next Face Waxing appointment in Broadmeadows, Bookwell has your back. In fact, the businesses we partner with have heaps of Waxing and Hair removal services, from waxing to eyebrow waxing. It's all right here. We hope knowing that treatments tend to be about 30 minutes long and cost about $25 make your hunt a bit easier. After all, looking after yourself shouldn't be too much hard work.
Look no further – Bookwell has the best treatment providers all listed in one place. Have a scroll through locations in Broadmeadows, take your pick, and book instantly. Feel free to give us a buzz on 1300-856-405 or email email@example.com if you'd prefer a chat. We'll point you in the right direction. We're here to make it easy for you to find your next Waxing and Hair removal treatment.


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2. Explain more details about chronic inflammation (with examples).Explain Causes of Chronic inflammation especially lifestyle, diet lack of exercise, obesity life-stress, genetic etc.…explain how lifestyles affect the cause of chronic inflammation.
3. Talk about Chronic inflammation associated diseases and treatments eg T2D. Atherosclerosis-cardiovascular, cancer.
1. Inflammation
Inflammation is referred to the localized physical condition where due to some physiological reactions, the body parts become reddened, hot, swollen and painful. Usually, these kinds of phenomenon results from the infection, external or internal injury (Aggarwal et al. 2012). The process is a part of complex biological response of body tissues towards the harmful stimuli including damaged cells, pathogens or irritants. Through these kinds of processes, the immune cells protect body system by involving different immune cells, blood vessels and molecular mediators. Through this process, the immune cells eliminate the initial causes of cell injury by clearing out the necrotic and damaged tissues from body and promote the tissue repairing system.
Its five basic signs, calor or heat, dolor or pain, rubor or redness, tumor or swelling and loss of function characterize the phenomenon, inflammation. It is the initial response of immune system and mediated by the immune cells, thus, it is classified under the innate immunity or cell mediated immunity in comparison to the adaptive immunity that is specific for each pathogen. There are mainly two types of inflammation which are acute and chronic inflammation (Cho and Yu 2012). Chronic inflammation is more severe form of inflammation than the acute one.
Acute inflammation
Acute infection is usually induced in the damaged tissues as a result of trauma, microbial invasion or noxious compounds. The acute inflammation is mediated by the immune cells and the secreted chemical mediators, which are known as cytokines and other molecules. In the case of acute inflammation, the anaphylatoxins are released at inflammation site, which are small inflammation-causing chemicals, these mediators promote the secretion of chemical mediators including histamine, prostaglandins or serotonin from the mast cells, thereby causing blood vessel expansion, making them more permeable (Daniluk 2012). In this way, the neutrophils are allowed to migrate into the affected tissue through diapedesis for clearing out the noxious substances in blood. The more blood cells accumulation causes redness and the destructive reactions cause heat. Most of bacterial or fungal infections cause acute inflammation. Lesions include pus, rash and abscess. For example, allergic anaphylaxis causes acute inflammation (Dietert and Luebke 2012).
Chronic inflammation
In contrast to the acute inflammation, the chronic inflammation is seen as a response to some viral infections and hypersensitivity reactions. It is seen in some infections where the inflammation is persistent. In contrast to the neutrophils and chemical mediators released by mast cells, the primary immune cells are T lymphocytes and macrophages here. The cytokines secreted by these cells causes more long-term damage to the tissues (French 2011). In the case of chronic inflammation, the acute infection allows continuous tissue damage to cells leading to tissue fibrosis. Lesions include fibrosis, rash or granuloma. Example includes autoimmune condition such as rheumatoid arthritis.
2. Chronic inflammation
Chronic inflammation is usually the persistent and ongoing inflammation process after an acute inflammation. If the infection persists with more tissue destruction after the phase of acute inflammation, it can be said that chronic inflammation has taken place. In some cases, some pathogens directly provoke chronic inflammation in spite of initiating an acute inflammation first. Increased permeability of capillaries, increased blood flow and many other factors of acute inflammation continue with chronic stage (Lichti 2012). Neutrophils enter into the infected tissue and quickly recruit lymphocytes and macrophages through chemical mediators' secretion. Macrophages initiate the phagocytosis process. Sometimes, they are not able to digest all the engulfed material and the pathogenic substances persist within macrophages while the macrophages are engulfing more, thereby continuing the symptoms of inflammation for longer period. In some cases, macrophages fuse and forms giant cells and these fused cells are found in the form of layers surrounding the damaged central core, which are known as granuloma. It is one of the significant features of tuberculosis (Ashton Acton 2012).
Causes of Chronic inflammation
There are a number of causes, which could cause chronic inflammation.
Sedentary lifestyle, stress and exhaustions are crucial cause of chronic inflammation. Consuming a huge number of antibiotics can cause inflammatory symptoms via cross-reaction. More exposure to toxin for example, farmers working with pesticides can cause chronic inflammation. Vitamin D is an important component of system modulation, lack of sun exposure lowers the immune system's ability to work properly, enhancing chance of inflammation (Roy et al. 2012).
There are a number of foods, which can cause inflammation. Sugar triggers a number of cytokines causing inflammation. Saturated fat is another food substance, which cause inflammation of adipose tissues. Thus, cheese, full-fat dairy products, grain-based desserts, red meat should be avoided in diet. Trans fat causes systematic inflammation. Gluten and casein are also causative agents of chronic inflammation. Thus, food substances containing these factors should be avoided from daily diet. Alcohol and smoking are also major causes of inflammation (Schillde 2013).
Lack of exercise
People having insomnia are prone to chronic inflammation due to over secretion of inflammation causing cytokines. Lack of sleep promotes inflammation. Individual experiencing autoimmune disease are seen to have less sleep which promote the situation with more pain. Exercise helps to active the immune system. Exercise causes healthy muscle contractions, which causes the secretion of cytokines like IL-6, IL-8 and IL-15, thereby contributing in anti-inflammatory actions (Wick and Grundtman 2012).
Obesity and depression
Macrophages infiltrate the adipose tissues and release another set of chemical mediators which further promote inflammation. It has been reported that the accumulation of macrophages also causes insulin resistance in obese people. In addition, evidence suggest that depression and stress has a significant link with chronic inflammation. At stressed condition, more cortisol hormones are produced which is also promoted to the cytokines released due to lack of sleep that is interconnected with stress. These are stimulators of chronic inflammation (Thilakarathna and Rupasinghe 2013).
Acute inflammation is followed by chronic inflammation signs through the signal transduction. JAK-STAT pathway has a major role in signal transduction. Mutation in these pathways can cause inflammation. Some autoimmune diseases are also caused by mutation in essential genes.
3. Chronic inflammation associated disease and treatments
Type 2 Diabetes
As described earlier, accumulation of macrophages at the site of inflammation has a major role in causing insulin resistance, which is the major cause of type 2 diabetes disease. Researchers found that accumulated macrophages secretes some immune mediators including TNF-alpha and other cytokines which are promoting the expression of some proteins which suppresses the insulin-signaling pathways, thereby making the system less responsive towards insulin and thereby loosing the control over glucose metabolism. It promotes the development of type 2 diabetes. FOXO 1 increase cytokine secretion, which has been shown to be more active during insulin resistance (Garc?a-Lafuente et al. 2009).
Avoiding sugar and saturated fat based food is the basic treatment of type two diabetes to reduce the chance of diabetes. Sulforaphane has been shown to have great response as an anti-inflammatory activity while acting against oxidative damage associated with inflammatory activities.
Atherosclerosis is a syndrome, which affects the blood vessels as a result of chronic inflammatory responses of WBCs present in the artery walls. The process is promoted by the LDLs as a result of failure of removing fats and cholesterol by the HDLs from macrophages. The result is formation of atherosclerotic lesion in artery, which is the cause of cardiovascular accident (Kawasaki et al. 2012). The retention of LDL particles promotes initial damage to vessel walls which promote inflammatory procedure. Macrophages further ingest oxidized LDLs and turn into foam cells which propagate the inflammatory process.
In the case of cardiovascular diseases, atherosclerosis is the major cause. High blood pressure, smoking, high cholesterol, all of these inflammatory phenomenon triggers cardiovascular diseases. The damage promotes inflammatory response and leads to the formation of plaque in artery. Two types of plaques are formed in the cardiovascular diseases as a result of inflammatory responses. Stable plaques in artery of heart cause chest pain and sudden rupture of plaque causes blood clot and myocardial infarction (Gentile et al. 2012).
Regular exercise and cessation of smoking are basic treatment. Combined treatment strategies are best for these cases. Lipoprotein transport behaviors have been shown successful results. Mediterranean diet can improve the symptoms. Medications for reducing high cholesterol can be a good treatment along with dietary improvement.
A number of inflammatory diseases increase the risk of cancer of an individual. For example, it has been found that chronic inflammatory bowel disease increases the risk of colon carcinoma. Bacterial, viral or parasitic infections or chemical irritants can cause chronic inflammation. Through the inclusion of proneoplastic mutation, apoptosis, adaptive responses the inflammatory mediators promote neoplasia (Guo et al. 2012). As much the inflammation persists, the risk of cancer increases. In this context, anti-inflammatory medications and healthy diet by avoiding inflammation-inductive foods can be helpful.
4. Components of chronic inflammation
Inflammation mediators
There are different chemical and biological mediators of chronic inflammation, which are important components of chronic inflammation. Cytokines are the most important agents having significant role in inflammation. The cytokines, which promote inflammation, are known as the pro-inflammatory cytokines, which involve IL-6, IL-8, IL-15, TNF-alpha. The chemical mediators of inflammation include histamine, postraglandin, bradykinin and serotonin. Histamine is one of the initial chemical mediators released from mast cells which attracts macrophages at the site of inflammation (Mathur and Pedersen 2009).
Neutrophils are most abundant granulocytes having a major role in inflammation process. These are the first leukocytes, which are recruited to the site of inflammation. They are able to eliminate the pathogens through phagocytosis. These cells have high capacity of infiltrating in the damaged tissues. These cells have a significant role in the chronic inflammation of joint. The granules in neutrophils secrete anti-microbial substances including toxic oxygen metabolites. And drive inflammation through antigen presentation and cytokine secretion. These are found in rheumatoid joints in large amount (Guo et al. 2012).
Monocytes are one of the important white blood cells. Monocytes migrate in different tissues while differentiating into macrophages. In inflammation, the macrophages has three major roles, phagocytosis of pathogenic substances, antigen presentation to the T lymphocytes and immunomodulation by producing and secreting different cytokines and growth factors. The chemical mediators secreted by the neutrophils make the macrophages active and these macrophages can infiltrate tissues easily. Activated macrophages can destroy the pathogens by phagocytosis more vigorously (Sica and Mantovani 2012).
Mechanism of macrophage activation or polarization
M1, M2 and M3 polarization
Macrophages play an essential role in regulation of the process of healing of wound and regeneration of tissue by changing their state of polarization in response to the stimulus of local microenvironment. The native roles of macrophages that are polarized includes the needs of tissue remodeling and biomaterials, yet directing the response of polarization has been mainly not present as a probable strategy to use in regenerative medicine up till now (Herder et al. 2015). The macrophages that are derived from the precursors of monocyte go through specific differentiation depending on the environment of local tissues. They give response to the environmental signals within then tissues such as the activated lymphocytes, microbial products and damaged cells to distinguish into functional phenotypes. The phenotype of M1 macrophage is differentiated by the production of elevated levels of pro-inflammatory cytokines, capacity to mediate resistance against pathogens, high production of reactive intermediates of oxygen and nitrogen, strong microbial properties and promotion of responses of Th1. On the contrary, the M2 macrophages are differentiated by their involvement in the process of remodeling of tissue, parasite control, and regulation of immune system. Kappa (NF-KB) is a nuclear factor, which acts as a signaling molecule in the M1, M2 and M3 Polarization (Herder et al. 2015).
5. THP-1 cell model
This model encompasses human leukemia monocytic cell line that has been widely utilized to study the mechanisms, functions, pathways of signaling and transport of drugs and nutrients involved with macrophages/monocytes. This model encompassing the cell line has become widespread for estimating the modulation of the activities of macrophages and monocytes (Qin, Z., 2012). THP-1 is a human monocytic cell line, which is derived from the patient suffering from acute monocytic leukemia. This cell line is utilized for the testing the cell lines of leukemia immunocytochemical analysis of protein-protein interaction and immunohistochemistry. These cells have C3b and Fc receptors and they are devoid of cytoplasmic and surface immunoglobulins. They are responsible for the production of IL-1 and stain positive for alpha-napthyl butyrate esterase. They exhibit increased production of carbondioxide during phagocytosis and can be distinguished into cells, which are like macrophage (Chanput et al. 2014).
Strengths and Limitation
In the present settings of research, THP-1 model is extensively used for the investigation of regulation and function of macrophages and monocytes in the cardiovascular system. In the studies, associated with the interaction between a variety of vascular cells and THP-1 cells, THP-1 cells offer several exceptional values like a model for investigating the mechanisms of the different stages of atherogenesis (Chanput et al. 2014). A few studies that are associated with the transcriptome, histone modification of THP-1 cells and microRNA profile, a number of molecules have been identified which may play crucial roles in regulating the macrophages and monocytes under pathological and physiological conditions. The limitation of this model is that there are noteworthy differences between the primary monocytes-macrophages and THP-1 cells and it is necessary to identify the differences between them. Moreover, both of them have diverse pathophysiological processes in programmed cell death or apoptosis (Qin, Z., 2012).
Advantage and disadvantage of THP-1 cells over other cell models
THP-1 cell line has some technical advantages in comparison to the other cell line models. For example, the genetic background of THP-1 cell line is homogenous leading to the minimization of the degree of variability in the phenotype of the cell. Another advantage is that the genetic modification of these cell lines by small interfering RNAs for the regulation of specific proteins is comparatively uncomplicated. The most regularly utilized read-out systems for reactions of THP-1 cells involves production of significant cytokines or transcription of the cytokines are significant and depends on the experimental designs, which are specific in nature (Chanput et al. 2015).
6. Methods of regulating chronic inflammation
Chronic inflammation is usually results from the infection, which can be bacterial, viral, parasitic or fungal. Thus, the primary way to control chronic or persistent inflammation is to take precaution against infection by infection prevention methods. The primary prevention method is having a healthy diet by avoiding substances that induce inflammation. Therefore, getting control is very important (Kawasaki et al. 2012). Red meat should be avoided highly as it causes inflammation. Fries, which are rich in gluten, should be avoided as it causes chronic inflammation. Bad fat or Trans fat also have pro-inflammatory activities, refines carbohydrates, acid forming food can cause inflammation, which should be avoided. Today, most of the natural vegetables are grown by applying harmful pesticides, which are major causes of inflammation. Thus, vegetables should be washed before consumption very carefully. Candida is a major opportunistic pathogen, which causes inflammation through infection of gut. Thus, keeping a healthy gut is very important to control chronic inflammation (Chanput et al. 2015).
7. Bioactive Molecules
Flavonoids and plant derived molecules
Flavonoids encompass a group of phytochemicals, which have exhibited several effects of health and have been studied comprehensively (Vezza et al., 2016). They are secondary metabolites in plants and belong to the category of polyphenols. Among the six common classes of food flavonoids, the ubiquitous distribution of flavonols has been observed in different plant foods while noticeable quantities of isoflavones have been discovered in the foods that are obtained from leguminous plants (George et al. 2016). Flavonoids have exhibited promising health enhancing effects in human cell cultures, experimental human and animal clinical studies. They have exhibited hypocholesterolemic, anti-inflammatory and antioxidant effects together with the ability to adapt cell signaling as well as gene expression associated with the development of diseases (Haid et al. 2012).
Sources and mode of action
The sources of Flavonoids are fruits, vegetables and spices. They are rich in the fruits that grow on trees. Citrus fruits such as lemons, oranges and grapes contain a high amount of falavonoids (Paul Dzoyem et al. 2013). Beans such as kidney bean are high in flavonoids. Their best property is to protect the body against reactive oxygen species. They have discovered to possess antimicrobial, antiviral, anti-inflammatory and antihepatotoxic activities. They also possess biochemical effects that lead to the inhibition of a variety of enzymes such as phosphodiesterase, xanthine oxidase, aldol reductase, cycloxygenase and lipoxygenase. They also have a role in the regulation of a number of hormones such as androgens, thyroid hormone and estrogens. They also show anti-inflammatory activities in exudative as well as proliferative phases of inflammation (George et al. 2016).
Anti-inflammation properties of flavonoids
The anti-inflammation properties of flavonoids in cellular models engages the inhibition of the activities and synthesis of a number of pro-inflammatory mediators like adhesion molecules, cytokines, c-reactive protein and eicosanoids (Haid et al. 2012). The studies on humans which aims to investigate the effects of flavoniods on the inflammatory markers are inadequate and are primarily focused on the sources of food that are rich in flavonoids but not on the molecules that are pure. Several of the studies lack evaluation of absorption of flavonoids or fail to relate the effect off inflammation with an alteration in the circulating levels of flavonoids (Paul Dzoyem et al. 2013).
In this literature review, recent literatures have been reviewed regarding the chronic inflammation. Chronic inflammation is one of the basic steps that progress towards severe human diseases, while increasing the risk of fatal consequences including cardiovascular accident or cancer. In this literature review, the basic concept related to the chronic inflammation and how chronic inflammation is related to the severe diseases has been discussed. Recent research has been found direct relation between chronic inflammation prevention and consumption of dietary flavonoids. From different recent studies, it has been analyzed that flavonoids have anti-inflammatory activities, which could have major impact upon treatment and prevention of chronic inflammation. Thus, flavonoids can be used as prophylactic agents. The role of flavonoids has been discussed here. Further studies should focus on in-depth analysis of the natural product to establish its use in treating chronic inflammation related diseases.
Reference List
Aggarwal, B., Krishnan, S. and Guha, S., 2012. Inflammation, lifestyle, and chronic disease. Boca Raton: CRC Press.
Chanput, W., Mes, J.J. and Wichers, H.J., 2014. THP-1 cell line: an in vitro cell model for immune modulation approach. International immunopharmacology, 23(1), pp.37-45.
Chanput, W., Peters, V. and Wichers, H., 2015. THP-1 and U937 Cells. InThe Impact of Food Bioactives on Health (pp. 147-159). Springer International Publishing.
Cho, C. and Yu, J., 2012. From inflammation to cancer. Singapore: World Scientific.
Daniluk, J., 2012. Meals that heal inflammation. Carlsbad, Calif.: Hay House.
Dietert, R. and Luebke, R., 2012. Immunotoxicity, immune dysfunction, and chronic disease. New York: Humana Press.
French, M., 2011. Inflammation in Chronic Disease Signature Initiative. Ottawa: Canadian Institutes of Health Research.
Garc?a-Lafuente, A., Guillam?n, E., Villares, A., Rostagno, M.A. and Mart?nez, J.A., 2009. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflammation Research, 58(9), pp.537-552.
Gentile, L.F., Cuenca, A.G., Efron, P.A., Ang, D., McKinley, B.A., Moldawer, L.L. and Moore, F.A., 2012. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. The journal of trauma and acute care surgery, 72(6), p.1491.
George, V.C., Vijesh, V.V., Dehigaspege, A.I., Lakshmi, C.A., Anbarasu, K., Kumar, D.R., Ethiraj, R., Kumar, R.A. and Rupasinghe, H.P., 2016. Mechanism of Action of Flavonoids in Prevention of Inflammation-Associated Skin Cancer. Current medicinal chemistry.
Guo, Y., Lip, G.Y. and Apostolakis, S., 2012. Inflammation in atrial fibrillation.Journal of the American College of Cardiology, 60(22), pp.2263-2270.
Haid, S., Novodomsk?, A., Gentzsch, J., Grethe, C., Geuenich, S., Bankwitz, D., Chhatwal, P., Jannack, B., Hennebelle, T., Bailleul, F. and Keppler, O.T., 2012. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology, 143(1), pp.213-222.
Herder, V., Iskandar, C.D., Kegler, K., Hansmann, F., Elmarabet, S.A., Khan, M.A., Kalkuhl, A., Deschl, U., Baumg?rtner, W., Ulrich, R. and Beineke, A., 2015. Dynamic changes of microglia/macrophage M1 and M2 polarization in theiler's murine encephalomyelitis. Brain Pathology, 25(6), pp.712-723.
Kawasaki, N., Asada, R., Saito, A., Kanemoto, S. and Imaizumi, K., 2012. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Scientific reports, 2.
Lichti, P., 2012. Identification of metabolic markers for the development of chronic intestinal inflammation.
Mathur, N. and Pedersen, B.K., 2009. Exercise as a mean to control low-grade systemic inflammation. Mediators of inflammation, 2008.
Paul Dzoyem, J., Hamamoto, H., Ngameni, B., Tchaleu Ngadjui, B. and Sekimizu, K., 2013. Antimicrobial action mechanism of flavonoids from Dorstenia species. Drug discoveries & therapeutics, 7(2), pp.66-72.
- Ashton Acton, P., 2012.Inflammation Mediators-Advances in Research and Application. ScholarlyEditions.
Qin, Z., 2012. The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature.Atherosclerosis, 221(1), pp.2-11.
Roy, S., Bagchi, D. and Raychaudhuri, S., 2012. Chronic inflammation. Boca Raton: Taylor & Francis.
Schillde, M., 2013. Structure function analysis of probiotic bacteria in mouse models of chronic intestinal inflammation. Mu??nchen: Verl. Dr. Hut.
Sica, A. and Mantovani, A., 2012. Macrophage plasticity and polarization: in vivo veritas. The Journal of clinical investigation, 122(3), pp.787-795.
Thilakarathna, S.H. and Rupasinghe, H.P., 2013. Flavonoid bioavailability and attempts for bioavailability enhancement. Nutrients, 5(9), pp.3367-3387.
Vezza, T., Rodr?guez-Nogales, A., Algieri, F., Utrilla, M.P., Rodriguez-Cabezas, M.E. and Galvez, J., 2016. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients, 8(4), p.211.
Wick, G. and Grundtman, C., 2012. Inflammation and atherosclerosis. Wien: Springer-Verlag/Wien.


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hey i love bright eyes and this said i should like curssive are htey as good as bright eyes
>>By brighteyesisthebombboy
(Tuesday, 2 Sep 2003 19:35)
They are very good, but not quiet the same as Bright Eyes, though chance is that you may love them when you love Bright Eyes...
>>By Campking
(Saturday, 6 Sep 2003 02:48)
cursive is rad. i saw them at a show in october. they were great. look into the danielson fam.
>>By smiths*w/in
(Monday, 29 Dec 2003 05:52)
cursive is good
>>By Jackthepumpkinking
(Monday, 8 Mar 2004 22:16)
judging from "the ugly organ " which is the only one I've heard they make a great band. good dynamics, clever use of cello, great melodies and nice lyrics
>>By thom
(Wednesday, 10 Mar 2004 13:00)
Tim Kasher is amazing. I don't know if i like The Good Life or Cursive more, both are great. Blackout has to be my favorite album from Kasher.
>>By inSAdie
(Thursday, 1 Apr 2004 00:20)
i like cursive although not at first...but i havent listened to them a lot..=(
>>By Box Trapped
(Thursday, 1 Apr 2004 00:52)
You defenatly should listen to them more often then, they have som really great stuff going on. Their earlier work is what now would be called emo or emocore, but their last albums are really good experimental pop or indie records, or what ever you should call it.... they know how to write songs and make things happen with notes...
>>By Campking
(Friday, 2 Apr 2004 01:20)
Cursive is so fun. They make me happy. I'm listening to them right now. Every song is so different, unlike other music which sounds all the same, with different words, which don't even variate much either. Did that make sense? hummm, i wonder...
>>By OpheliasViolets
(Sunday, 25 Jul 2004 07:25)
i heart cursive, :oh sangria wont u bless these starving lips: thats a lyric from "dirt of the vineyard" oh my, cursive is awesome, i saw them AGAIN! yay........viva the cursive sangria tale *^_^*
>>By Singme2smiths
(Tuesday, 10 Aug 2004 02:07)
Art is Hard
Cut it out- your self-inflicted pain
is getting too routine
the crowds are catching on
to the self-inflicted song
Well, here we go again
the art of acting weak
Fall in love to fail
to boost your CD sales
(And that CD sells- yeah, what a hit)
You've got to repeat it
you gotta' sink to swim
If at fist you don't succeed
you gotta recreate your misery
'cause we all know art is hard
young artists have gotta starve
Try, and fail, and try again
the comforts of repetition
Keep churning out those hits
'til it's all the same old shit
Oh, a second verse!
Well, color me fatigued
I'm hiding in the leaves
in the CD jacket sleeves
tired of entertianing
some double-dipped meaning
a soft serve analogy
This drunken angry slur
in thirty-one flavors
You gotta' sink to swim
immerse yourself in rejection
regurgitate some sorry tale
about a boy who sells his love affairs
You gotta' fake the pain
you better make it sting
you're gonna' break a leg
when you get on stage
and they scream your name
"Oh, Cursive is so cool!"
You gotta sink to swim
impersonate greater persons
'cause we all know art is hard
when we don't know who we are
:::sighs::: (girly sigh)
>>By Singme2smiths
(Tuesday, 24 Aug 2004 03:41)
Tim Kasher ***Sigh*** marry me. age is but a number
>>By OpheliasViolets
(Sunday, 5 Sep 2004 07:16)
The new good life cd is really fucking good. thats tim from cursives side project. the good thing about cursive is that not one of their cd's sound alike...but they are all amazing.
>>By pimp c bitch
(Monday, 18 Oct 2004 21:10)
"ill stop speaking for you if you stop speaking for me"
>>By geminice
(Wednesday, 20 Oct 2004 20:34)
ok so ive only listened to the ugly organ and well the martyr..but all in all i love cursive!!
>>By Box Trapped
(Tuesday, 6 Dec 2005 00:08)
i will get to taste cursive on nov. 25...it will be sooo good.
>>By odnanref
(Saturday, 4 Nov 2006 03:31)
Cursive are one of my all-time favorite bands. Not only do they put out great albums, but they put on a great live show. Tim Kasher is the best front man in indie rock in my opinion.
>>By jeremyveggie
(Wednesday, 9 Feb 2011 06:27)
The discussion board is currently closed.


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Sie sind hierStartseite › Publikationen ›
|Instructional Design for virtual worlds: Basic principles for learning environments
|Book Chapter
|Year of Publication
|Book Title
|Looking Toward the Future of Technology-Enhanced Education: Ubiquitous Learning and the Digital Native
|Ojstersek, N, Kerres, M
|Ebner, M, Schiefner, M
This paper gives an overview of the didactic elements relevant to learning opportunities in virtual worlds. Moreover, the specific requirements of virtual worlds are investigated in more detail using the C3-model of didactic components. Following this model, the specifications of virtual worlds are illustrated with regard to components content, communication and construction. The use of virtual worlds is often connected with the hope for stronger immersion, which is encouraged by the possibility of three-dimensionality and the representation of the learner by a virtual representative. However, learning-/teaching processes are not automatically improved by the use of virtual worlds. The possibilities offered by potential virtual worlds can only be honoured when a dedicated didactical concept is carried out. This means a complex composition process which has to take the specific features of virtual worlds into consideration.
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New Publications
- Also sprach Zarathustra! Eine kritische Betrachtung von Mythen aus der Bildungsforschung
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- Immersives Lernen? Mediendidaktische Perspektiven auf Augmented und Virtual Reality
- Lernen im Ehrenamt: Vernetzung und Reflexion mit digitalen Medien


text:
- Breastfeeding Breastfeeding Mom, Tumulong Sa NICU Babies Na Nakasama Ng Kanyang Anak Na May Birth Defect
- Real Parenting 'My Child Does't Need A Sibling': Pinoy Parents Share Their Choice To Have One Child
- Food 6 Healthy Homemade Recipes for Your Baby (7 to 8 Months)
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10 Offbeat Christmas Movies That Can't Be BeatContributing writer Julian Vorpal gives a list of unforgettable Christmas movies that moms and dads can enjoy by themselves or with the entire family.by Julian Vorpal .
Whether you're all together after Christmas dinner or relaxing alone by yourselves after a slew of Christmas parties, it's always a good idea to chill out and enjoy a great movie. Here are some unlikely suggested titles that will definitely put you in the mood for more holiday cheer!
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You are here: Motorcycle For Sale > Kymco > All Makes,Kymco,SUPER 8,AL,Kymco SUPER 8 Motorcycles in Mobile - New and Used Motorcycles on CycleTrader.com,
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2014 Kymco SUPER 8 - Kymco
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Additional Details
- Year: 2014
- Make:Kymco
- Model:SUPER 8
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- Location: Mobile, AL
- Mileage:
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European industry for vehicle management systems to 2030 – featuring derive systems, element fleet management & GPS insight among others
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Global Automotive Digital Instrument Cluster Market (2020 to 2025) – Growth, Trends, and Forecasts
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Global Autonomous Trucking Market Report 2020: COVID-19 pandemic has underlined the need for autonomous trucks – forecast to 2040
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Cooper Model 22 Phoenix 22-250 NIB
Guns International #: 101554655 Seller's Inventory #: g-i-198327
Category: Cooper Arms Rifles - Varmint - Predator Rifles
Seller's Information
When emailing or calling sellers direct, please mention that you saw their listing on GunsInternational.com
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Install and perform maintenance on wiring, control, and lighting systems. Electricians work on electrical components for buildings that are finished, and no longer under construction. They are competent at reading blueprints and technical diagrams, understand and follow the regulations set out in the government's National Electric Code, and use a range of equipment to test for and identify electrical problems. When they discover an issue, electricians repair or replace the affected wiring or device.
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I am selling my Dell U2717DWH (White) monitor. It comes with its own 4 USB 3.0 ports. I have the HDMI cable along with it and a power cable as well.
Selling as I am upgrading to a bigger one. Will accept cash or Revolut.
Product Description: Dell Ultra Sharp U2717D - LED monitor - 27". Device Type: LED-backlit LCD monitor - 27". Energy Class: Class A. Features: USB 3.0 hub. Panel Type: IPS. Aspect Ratio: 16: 9. Native Resolution: 2560 x 1440 at 60 Hz. Pixel Pitch: 0.2331 mm. Brightness: 350 cd/m². Contrast Ratio: 1000: 1. Response Time: 8 ms (typical); 6 ms (grey-to-grey). Color Support: 16.7 million colors. Input Connectors: HDMI (MHL), DisplayPort, Mini DisplayPort. Display Position Adjustments: Height, pivot (rotation), swivel, tilt. Screen Coating: Anti-glare, 3H Hard Coating. Color: White. Dimensions (WxDxH) - with stand: 61.13 cm x 20.03 cm x 41.02 cm.
- Collection
- Delivery
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- Cash
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- To be arranged
1 month ago


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Mathmatics Colloquium - ""Severi varieties of projective surfaces"
Speaker : Adrian Zahariuc , University of Windsor,
Adrian's interest are in algebraic geometry, with a particular focus on classical questions as well as enumerative geometry. He is a former student of Joe Harris, a world-renowned algebraic geometer at Harvard University who is also known for his several well-written books on the subject.
Abstract : Severi varieties are spaces which parametrize projective plane curves of fixed degree and geometric genus, and this definition may be easily extended to other projective surfaces by taking the spaces which parametrize curves of fixed homology class and geometric genus on the given surface. In this talk, I will first give a gentle and concrete introduction to these objects, and then I will focus on a question which (although known for the projective plane) is still open for most other projective surfaces, namely the question of whether the Severi varieties are irreducible. This question can be rephrased as follows: is it possible to continuously deform any curve on the surface into any other curve on the surface of the same homology class and geometric genus while keeping the genus fixed throughout the deformation?
Lectures, Seminars
Join Zoom Meeting https://us02web.zoom.us/j/86230383324?pwd=SnRvUEx6WDhLeE1yaFIyN01ONFZkZz09 Meeting ID: 862 3038 3324 Passcode: 087743 One tap mobile +12532158782,,86230383324#,,,,,,0#,,087743# US (Tacoma) +13017158592,,86230383324#,,,,,,0#,,087743# US
Ellen LynchMathmatics Colloquium - ""Severi varieties of projective surfaces"


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You are your partys candidate for President.Who do you choose as your vice pres. ?If you don't want to be assassinated,pick someone Everyone hates.George Bush did it,now its your turn.Who to pick? My choices: Ronald Reagan,Jesse Camp, and the sdmb favorite:ARG!!
Alright, I choose Charles Manson. Then the only people that would assassinate me would… would be…
Maybe this isn't such a hot idea.
Howard Stern!!
Brian O'Neill
CMC International Records
AIM Scrabble1
Yahoo Messenger Brian_ONeill
The ultimate assassination insurance is to piss off those who couldn't hit you if the gun was in your mouth. I spoke once with a police bodyguard of the premier of Saskatchewan (where I was raised): the premier was sucking money from the urban middle class and throwing it to the rural areas, where his greatest support was. The bodyguard complained that if someone did pull a gun and start firing, he'd hit everyone but the premier since the people who hated him were pencil pushing desk jockeys who didn't know one end of a gun from another.
Geese could you guy's be any more callous?
We are talking about the murder of a human being.
Vanilla-Nice My fucking ass Take it to the pit
Dear Mr. Ghandi,
When issuing an invitation to the BBQ pit, please do not begin the festivities before the parties in question have reached that forum.
Thank you for your cooperation.
GQ Mod for The Straight Dope
This idea supposedly dates back to the early days of the Roman Empire, when the Emperor Tiberius allegedly chose his nephew Caligula as his successor because he knew how evil he was. Tiberius' theory was that after a few years of Caligula's rule, everyone would forget his own lesser crimes and remember him fondly.
Ike had the Trickster. And the Trickster did have Spiro Agnew, didn't he?
Ranger Jeff
*The Idol of American Youth *
Pauly Shore.
btw, Ghandi, no one is talking about killing these people, anymore than They were talking about killing Dan Quayle when They commented that George Bush would never be assassinated.
Pauly Shore is right up there with Dan Quayle on my list as well but the ultimate in my opinion would be Kathy Lee Gifford.
I've never heard that story about Caligula before. From what I've heard, Caligula was actually a pretty nice guy (at least by the standards of the time) for a couple of years after becoming Caesar; he apparently went insane later and is now remembered primarily for that rather than the first few years of his rule.
I think that was Nero, not Caligula. As far as I can recall, Caligula was a complete wacko from the get-go. Nero definitely had a honeymoon period.
John W. Kennedy
"Compact is becoming contract; man only earns and pays."
– Charles Williams


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Apologies to all who have sent us emails over the past week – our email service is experiencing difficulties, and a lot of emails are getting lost. You may not have received a reply because we probably didn't receive your email. Please call 90906181 for enquiries/sales during business hours while we get our technical issues […]Continue reading
Full Leather Books Back in Stock
Gorgeous full leather, 22K gilt Collector's Editions back in stock! 1. The Divine Comedy of Dante 2. Grimm's Fairy Tales 3. Eight Plays – Anton ChekhovContinue reading
Happy National Day!
Today, we mark the day "Singapore is expelled from Malaysia and becomes the only country to date to gain independence unwillingly," as Wikipedia so succinctly puts it. Happy National Day, everybody! Here are some other historic events that took place on 9 August. 117 – Trajan, Roman emperor, dies 1483 – Opening of the Sistine […]Continue reading
19th Century Advertisements
19th century advertisements are extremely fun to read, and you often find them as part of the early "mass market" printings of the day. These were small books which people could take with them on the train. Much like the magazines of today, the books were littered with advertisements for all sorts of products, usually […]Continue reading
All about first editions
Today, first editions are very popular as collectors' items, especially modern firsts. But what exactly is a first edition, and are all first editions valuable? Here are some tips: 1. There are differences between the first edition, first printing, and first impression. Although people usually use the phrase "First Edition", what really counts is the […]Continue reading
Eid Mubarak
Eid Mubarak, Selamat Hari Raya to everybody!Continue reading
Revised Opening Hours for July
Change in opening hours for the month of July: please note that GOHD Books will open from 1:30pm to 7:00pm for the month of July – we will be closing a half hour earlier than usual for the month.Continue reading
Announcement: Shop Closure 28 June – 2 July 2014
GOHD Books will be closed from 28 June to 2nd July 2014. We'll re-open on 3rd July. All online purchases made during this period will only be delivered on 3rd July, after we re-open.Continue reading
Greek, Classical Chinese & Latin Courses Starting Soon
We would like to inform you that a new round of our Latin, Ancient Greek and Classical Chinese courses for complete beginners will be starting again very soon. The details are as follows. Ancient Greek Module 1 Saturdays 4pm-6pm, commencing 7 June 2014 Number of sessions: 4 Course fee: $500/module Early registration discount: 15% at […]Continue reading
Arabian Nights Back in Stock
We are very happy to restock the following 2 editions of The Arabian Nights – editions that are becoming more and more sought after over the years: 1. The Arabian Nights Entertainments (2 Volumes) 2. The Arabian Nights, III Vol Set (1934)Continue reading


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In particular, the terminology surrounding health care and senior care can sometimes lead you to feel confused and overwhelmed. A list of common terms has been developed by Always Best Care to assist you through this process. It can however be a daunting task to understand what type of care is right for your loved… Read more »
Posts Categorized: Home Care
Interventional Radiologists Specialistst – Guide
An interventional radiologist is a doctor who specializes in treatment of patients with a variety of health problems. These problems include: coronary heart disease (CHD), cardiac rehabilitation, pulmonary rehabilitation, respiratory problems, eye problems, ear problems, hearing problems, skin problems, kidney problems, pancreatic disease, thyroid conditions, and many more. Patients who are interested in getting a… Read more »
Columbus Home Care – Things To Know More
Senior Care Services has become one of the most popular hospital-based initiatives designed to address the health and well-being of senior patients. Our mission is to provide world-class medical care for our aging population by implementing a holistic health-care system that addresses a variety of issues, from prevention to recovery. We believe that the combination… Read more »


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Shop Impact Crushers For Sale. Choose from 26 listings to find the best priced Impact Crushers by owners dealers near you.
Shop Impact Crushers For Sale. Choose from 26 listings to find the best priced Impact Crushers by owners dealers near you.Learn More
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Dilshan was personally knowledgeable about his inclusion by the nationwide head coach Mickey Arthur.
Cricket has witnessed a number of rags-to-riches tales and Sri Lanka's newest fast-bowling sensation Dilshan Madushanka may very well be a brand new addition to it if he lives as much as the expectation. Whereas he's but to earn a call-up from Sri Lanka's senior workforce, the teenager is on the best path at current. He was lately included in Sri Lanka's coaching squad for the forthcoming South Africa tour.
The 20-year-old left-arm medium-fast bowler is one among the many 22 gamers chosen for the coaching. Madushanka has confronted a number of hurdles in his life however has overcome all of them to this point. His father Sujith Krishantha is a fisherman. He didn't pursue increased research both to give attention to the sport. Madushanka has studied as much as Grade 11 (Odd Ranges) and is now solely concentrating on a profession within the sport.
He has performed three first-class matches to this point. His elder brother can also be related to the game. Madushanka's elder brother, Sudesh Nirmal performs with the softball whereas his youthful brother Nipun is learning in Class X. The highly-rated pacer can be trying to make his mark whereas he joins the Sri Lankan workforce for the coaching camp.
Unbelievable expertise: Dilshan Madushanka
Forward of becoming a member of the camp, Dilshan Madushanka stated that his inclusion in Sri Lanka's coaching squad got here as a shock for him. On the identical time, he acknowledged that he was completely happy to obtain the decision and vowed to cement his place within the workforce with onerous work. Madushanka will probably be leaving for Kandy on Wednesday to affix the squad. Sri Lanka will practice on the Pallekele Worldwide Cricket Stadium from November 13-22.
"It was unbelievable. To be frank, I didn't anticipate it to be occurring so quickly. Nevertheless, I'm completely happy to be within the squad," Madushanka was quoted as saying by bdcrictime.
"Now with my onerous and honest work I'll attempt to cement my place within the workforce," he added.
Apparently, Dilshan was personally knowledgeable about his inclusion by the nationwide head coach Mickey Arthur. Sri Lanka are but to announce the squad for the tour and if Madushanka goes on to make an impression, he could be included within the squad.


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Apache 65
Apache 65: Kingdom of the Snake
$9.82 $11.98
Artist: Apache 65
Artist: Apache 65
Title: Kingdom of the Snake
Product Type: COMPACT DISCS
Enter the Kingdom. New Orleans is the location of Apache 65's new soundtrack of cinematic noir 'Kingdom Of The Snake'... The sequel to 2013's blood and sand epic 'La Bella Donna Di Morti.' Apache 65's sound combines spaghetti-western surf and Texas garage rock and roll. But on 'Kingdom Of The Snake', the band draws in influences like the imagery of New Orleans-based photographer Clarence John Laughlin, contemporary crime writers like James Ellroy and Jim Thompson, as well as the many various sights and sounds of the Basin City. 'Kingdom Of The Snake' tells the hallucinogenic tale of a man's first-hand descent into murder and madness. Musician Hans Frank (Glambilly/Smart Boyz) guest stars as the album's narrator... A killer with a haunted soul... lost among wet streets shimmering with crackling neon lights. The album begins with the garage soul of 'Lazy-Eyed Stranger'. Then, followed by the manic fuzz instrumental 'Three Short Steps.' As the narrator wrestles his mind for meaning, he wanders in shadows. The album keeps pace with the slow organ creep of 'Storyville', then submerges into the hypnotic blues of 'Obsidian Punch.' At the end, the ghostly voice of the narrator dissolves into the ether. Is he a ghost? Are we hearing the final words of a killer?... Or the slain? Who is the Kingdom Of The Snake? The album ends with a sonic return to South Texas with the galloping spaghetti-surf rocker 'Caballito Del Mar'. Recommended if you like: Link Wray, X, Tom Waits, Davie Allan & The Arrows, The Sadies, Brian Jonestown Massacre. Apache 65 is a quartet based in San Antonio, Texas. Founded in 2012 as a side project by members of the Saturday Night Satellites and Mosquitohead. Originally, the band was designed as a way to produce soundtracks to imaginary movies. After completing the first album 'La Bella Donna Di Morti', founding member Brian Parrish recruited an all-star band featuring luminaries of San Antonio's instrumental surf scene for Apache 65 live debut in March 2013. This early line up included members of the Saturday Night Satellites, the Sandworms, and the Phantomatics. But Apache 65 is not a 'surf' band. Nor is it band that will settle of one style of music. The band spent the sweltering Summer of 2013 tightening it's sound and stage testing the songs that make up the bulk of 'Kingdom Of The Snake'. The album's haunted noir feel was crafted by guitarist and singer Harvey McLaughlin (The Sandworms/The Hares), then inspired Parrish's dark soundscapes that weave throughout the album. 'Kingdom Of The Snake' marks the debut of vocalist Georgia Walker, and the return of veteran bassist Mike Pittman (formerly of Snowbyrd). Apache 65 draws upon it's influences of surf, soul and psychedelia... but not pidgeon-holed by any genre or sound. In many ways, 'Kingdom Of The Snake' is an album out of time. Apache 65 writes it's own musical rules, but with a reverence for real rock and roll and American music.
1.1 Introduction
1.2 Lazy-Eyed Stranger
1.3 Death in Algiers
1.4 Three Short Steps
1.5 Kingdom of the Snake, Pt. 1
1.6 Storyville
1.7 Kingdom of the Snake, Pt. 2
1.8 Obsidian Punch
1.9 The Spanish Gate
1.10 Caballito Del Mar


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What is geocacheing?
A geocache is a 'box' at a specific location that contains items to make a note of, games to play or anything really. They can be placed in boxes, magnetic boxes, containers hidden from plain view, etc. They are a bit like a "timecapsule" – but one could contain a clue to where the next one is and so on so you are taken on a tour with bits of information about the area.<p class="has-black-color has-text-color" value="<amp-fit-text layout="fixed-height" min-font-size="6" max-font-size="72" height="80">Find a geocache near you – we have a few on the Arbo!Find a geocache near you – we have a few on the Arbo!
You can "play" using a mobile app from Google Play or App Store – download the app from this page.
We will be creating geocaches around the Arboretum, canal and the Bramblewood Project so while getting a tour of the Arboretum, you get to find the geocache and find out more or carry out the task given.
We will be buying things to make our geocaches from shops like ukgeocachers and other shops found on geocacehing.com