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Working in the production and manufacturing process of E-Liquids including:
- Set up machines (product, cleaning etc.) to start a production cycle
- Control and adjust machine settings (e.g. speed)
- Feed raw material to semi-automated machines
- Maintain activity logs
- General warehouse duties
- Picking and packing orders for Distribution and Online Sales, as required
Future Prospects
Upon completion of the apprenticeship you could progress into full-time employment.
Reality Check
The company may wish to interview applicants before the closing date, resulting in the vacancy being filled before the given date.
Skills Required
- You should be highly energetic, enthusiastic, resourceful, resilient and be able to demonstrate a sense of urgency, momentum and self-discipline to get things done!
- You must have high energy, a great attitude, personality and a willingness to strive to be the best
Qualities Required
- Keen and willing to learn
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Qualifications Required
No formal qualifications required.
Training Provided
- Intermediate level 2 Apprenticeship in Supply Chain Warehouse Operative, including NVQ and functional skills maths and English
- Work based learning

subset: commoncrawl


text:
'… Zutphaniae …'
Etching / engraving, handcoloured on hand laid paper.
Sheet size: 23,5 x 18,5 cm. (9,3 x 7,3 inch). Image size: 15,6 x 12,3 cm. (6,1 x 4,8 inch).
From: 'Les guerres de Nassau…', by G. Baudartius / G. Baudart, published in Amsterdam by M. Colin de Thovoyon in 1616. This important work on the first five decades of the 80 Years War raging in the Netherlands, Belgium and the western part of Germany from 1568-1648, was written from a Contra-Remonstrant point of view. Many of the plates are after 'Geschichtsblatter' by Frans Hogenberg and after plates from J. J. Orlers' work. New plates were added as well.
Condition: Good, given age. Rear text. General age-related toning and/or occasional minor defects from handling. Please study scan carefully.
Keywords: SIEGE OF ZUTPHEN IN 1584


text: In this article we will briefly discuss startup brand storytelling and why it's important for your startup. The age of market domination by product features and low prices is almost non-existent. Innovation and access to technology is becoming cheaper and easier. Startup brands need to be and communicate authenticity now more than ever. Whatever your product offers, can be replicated quickly and cheaper in a shorter space of time. Instead of focusing on what makes your product functional, start thinking about defining and communicating why it exists in the first place. This means actually having concrete values, following them through action and not just caring about profits. Brands that have done this with integrity have seen up to 50% more earnings. Genuine brand storytelling is not new thinking at all. In fact, some of the world's greatest brands we know and love today, have long been sharing their stories more than their features. Protesters have changed policies and captured the world's attention — driven by strong conviction and purpose. All because humans connect with humans. Not features and specs. Startup brand storytelling is becoming the new craze. With some marketers forging stories in an attempt to win the hearts of audiences. This is incredibly dangerous. Sooner or later you will be exposed and this will hurt your brand more than strengthen it. True value and a deep connection with your audience, will come when you reach deep within and genuinely ask yourself why you exist. Why should your audience care about the solution you are proposing? you may also enjoy... Don't fake it. You won't make it.Now as the world awakes and realises that true visibility comes from authenticity, I say "Don't…Read More0 Comments2 Minutes Rebranding ZimbabweBrand new Visual identity for Zimbabwe. This is Rebranding Zimbabwe — a nation that has seen…Read More0 Comments1 Minutes Daddy is Brown.And so it was — she landed on brown. Immediately, as she chose that colour for her rendition, I was…Read More0 Comments1 Minutes PrevNext


text:
Trendy Jacket
Played 6240 times
Trendy Jacket game information:
Don't blow your budget on a trendy jacket that's going to be outdated next year. Instead, look for updated looks and find your dream jacket for a song. Here are some good items on trendy silhouettes.
How to play:
Use Mouse to interact.
Add this game to your website or blog!
Popular Tags
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text:
Frozen For:
Stallion Details
- Discipline: Showjumping
- Height: 16.2hh
- Stud Fee: P.O.A
- Breed: KWPN
- Colour: Dark Brown
- Year of Birth: 1995
Contact Details
- Contact: Elite Stallions
- Email: email@example.com
- Tel: 01483 890589
- Web: www.elitestallions.co.uk
Numero Uno completed his performance test triumphantly: he received a 9.0 for canter and scored an average of 8.5 for jumping components. His explosive take-off earned him 9.0 points.
Dam Jolanda, like the Olympic showjumping stallion Lux, descends from Lord Calando. Grand dam Feinschnit (Ahorn hann) supplied, in combination with Gondelier, the national showjumping horse Kapitol, who as a five-year-old gave an excellent performance in the world championships for young horses at Lanaken. The mother line continues via the well known stallion Farnese to the mare Fernsicht (Ladykiller xx), who is a full sister to the reputable stallion Lorenz. This famous Holstein lineage, which is registered under number 429, also produced the stallions Aldato (Anblick xx), Heidelberg (Ladykiller xx) and Benedictus (Benvenuto xx).
After a successful show jumping career with European Champion Marco Kutscher, Numero Uno today has turned out to be one of the leading sires in the world. He is father to six approved KWPN stallions, is sire to many champions in international show jumping, ability tests and stallion approvals.
As of January 2011, sons Tamino and Tyson are both on the A-squad for the Dutch jumping team. In the same month, at the Amsterdam grand prix, Tamino was 3rd, Unaniem 5th.
Now no. 11 on the WBFSH stallion rankings.
Will not produce chestnuts.


text: Escada has agreed to farm out the design, development and production of a portion of its footwear line to Vicini, the company of Giuseppe Zanotti that already produces about 400,000 pairs annually under his own name and those of brands such as Roberto Cavalli and Gianfranco Ferré. Escada, which has been developing its footwear collection in-house for several years, will continue to work with other Italian producers for the rest of its line through its office in Florence. Escada's creative director, Damiano Biella, will continue to supervise the design of the whole collection.


text:
Louise: You're asking me to trade one form of punishment for another. June 10, Retrieved July 15, Ethan learns he's been denied a future job at the hospital but wrongly assumes his breakup with Vivian is to blame.
The two, reunited at last, agree to get married. She tells him that he needs to resolve the problems in his marriage. In OctoberWashington University researcher Dr. So how do you bring that character onto the small screen, when it presses so hard against the tropes and easily digestible stereotypes people prefer their on-screen women to embody?
Archived from the original on July 3, Virginia starts selling diet pills to make enough money to get by.
Masters of Sex Videos. Bill and Virginia begin working with Dan Logan, who is trying to capture the smell of sex. Director Lawrence Trilling. Meanwhile, Virginia is working out a new custody agreement with her kids.
Coupled, no less, with the decidedly unkind attitude society had towards all women during the 40s and 50s? I just She was ambitious, determined, and cavalier about her lovelife.


text:
[Reading] ➸ Sneet inde Author Ken Follett – E17streets4all.co.uk Et planlagt indbrud mod en medicinalfabrik i Skotland, der skal skaffe d delige antistoffer til terrorister, besv rligg res af en voldsom snestorm, der h mmer b de forbrydere og forf lgere Et planlagt indbrud mod en medicinalfabrik i Skotland, der skal skaffe d delige antistoffer til terrorister, besv rligg res af en voldsom snestorm, der h mmer b de forbrydere og forf lgere.
Ken Follett is one of the world s most successful authors Over million copies of the books he has written have been sold in over countries and in languages Born on June th, Paperback ↠ Sneet inde PDF ò in Cardiff, Wales, the son of a tax inspector, Ken was educated at state schools and went on to graduate from University College, London, with an Honours degree in Philosophy later to be made a Fellow of the College in He started his career as a reporter, first with his hometown newspaper the South Wales Echo and then with the London Evening News Subsequently, he If you re looking for a CBR and CBZ reader worked for a small London publishing house, Everest Books, eventually becoming Deputy Managing DirectorKen s latest book, A Column of Fire, is a historical novel about spies and secret agents in the th century, the time of Queen Elizabeth I Set partly in the fictional town of Kingsbridge, it is a sequel to bestsellers The Pillars of the Earth and World Without End and was published in September His previous project, The Century Trilogy, has sold million copies worldwide The three books tell the story of the twentieth century through five generations on three continents Ken s first major success came with the publication of Eye of the Needle in A World War II thriller set in England, this book earned him the Edgar Award for Best Novel from the Mystery Writers of America It remains one of Ken s most popular books In , Ken s epic novel about the building of a medieval cathedral, The Pillars of the Earth, was published It reached number one on best seller lists everywhere and has sold over million copies worldwide It was turned into a major television series produced by Ridley Scott, which aired in World Without End, the sequel to The Pillars of the Earth, proved equally popular when it was published in Ken has been active in numerous literacy charities and was president of Dyslexia Action for ten years He was chair of the National Year of Reading, a joint initiative between government and businesses He is also active in many Stevenage charities and is President of the Stevenage Community Trust Ken, who loves music almost as much as he loves books, is an enthusiastic bass guitar player in two bands He lives in Stevenage, Hertfordshire, with his wife Barbara, the former Labour Member of Parliament for Stevenage.
- Paperback
- 323 pages
- Sneet inde
- Ken Follett
- Danish
- 21 February 2017 Ken Follett
- 8777147804


text:
It's a trick on the old Z-buffer called a logarithmic Z-buffer (equations and examples in this link)
But as seen in the link below, it has some issues, so this independent developer modifies it to remove the artifacts (more equations in the link as well)
This developer (and he's a very experienced and seasoned developer) is so impressed with the technique that he thinks Z-buffer precision problems will become a thing of the past, if this stuff was implemented in the BGE and 3D view it could greatly expand the draw distance we could possibly use in our games with the default Blender-Unit size with no Z-buffer precision problems. And this will work on today's hardware.
What do you think?


text:
Who called from number 1765095642
Phone number Comment 1765095642 Rang twice . Left silent voice messages.. now blocked
Ripon Longitude : 43.8771000
Ripon Latitude : -88.8457000
Number ranking:
First search:
Last search
|Phone number
|Rang twice . Left silent voice messages.. now blocked
|H.D.Kote- Mysore
Number Search: Check phone number from Ripon ??? Among the missed calls in saved reviews in our database by our users, you can usually meet all kinds companies and institutions such as offices, courier companies, transport companies, telemarketing, insurance companies, sales by telephone, consolidation loans, cash loans and payday loans as well as mobile telephony (Orange, T-mobile) calling us with a new offer. It is in these departments that many calls are often executable, but often after calling back on a given phone number, no one answers or We connect directly to the central where we do not know who called us. In this situation, the best solution is to find an opinion on a given telephone number, to know who called us and whether we should call back or next time we answer the phone.
one thousand seven hundred sixty five ninety five six hundred forty two
one seven six five zero nine five six four
|1765 095 642
|17 65 09 564 2
|176 50 95 64 2
|17-65-09-564 2
|0044 1765-095-642
|00 44 176 50 95 642
|17 65 09 564 2
|(17) 6509 564 2
|00 44 (17)6 50-95-64-2
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Leighton Buzzard
did not anser
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doctors general practitioners hallam c
Utilita calling but I wanted to change back to them anyway
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kenlar computers london maintenance and repair of office, accounting and computing machinery
pain in the neck
I have received a text message saying I've got to ring this number about my Debenhams account. First time I've ever received such a message & I've been an account holder for approx 8 years. I haven't called it as to me it looks like a spam text.
framing services fox & sharples (London)
swift pets & gardens pet supplies birmingham b31 3jw
newsagents - retail londis - Rhyl
montgomery exhibition se ces
Newsagents - Retail Dillons Newsagents Ltd. Halstead
Just went off reviews
travel agents okavango tours & safaris (London)
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men's hairdressers rob johnstone's barber shop stoke-on-trent
bakers neil faulkner sidmouth
creme dor ltd beverley manufacture of food products and beverages
livestock and others christopher brown newport isle of wight
You can here a call centre in back ground but it hangs up
ace auto & bike specialists garages repair and modification woking gu21 5sb
builders p saxby aylesford
equilon ltd burgess hill
kitchen and table goods cheshire cookers knutsford cheshire
take away al-rawshi (London)
computer systems and software mardev systems solution - Cardiff
jewellers discount jewellers (port talbot) ltd - Port Talbot
charities and voluntary organisations african rights (London)
dentists j d hull (London)
filippo tosetto london london
cottage craft spirals high peak d manufacturing
Schools and Colleges William Edward School & Sports College Grays
day centres glasgow city mission
Demanded to speak to my husband re windows installed 10 years ago, name of firm was not the one which installed the windows, would not explain why needed to contact us and accused me of being an intruder when I queried his status.
electronic engineers grampian electrotech services
a b c promotional gifts ltd - promotional items Leeds
car accident crap call
model design construction
bournemouth self storage
Accident claim company. Unsolicited. Time waster. Hang up.
Premium APP
Say goodbye to No Caller ID. Unmask all withheld / no caller id calls instantly.
Absolute pain in the ₩@$! ... silence when you pick up .... called every day for the past week, now blocked.
A woman called asking if I was in a car accident. I told her that I have epilepsy (which I do, therefore I am unable to drive). She then asks "when was your accident?". I quickly replied with " I have epilepsy so I am unable to drive". The woman said "okay
computer consultants networks & systems (training) ltd (London)
w h ireland ltd manchester j financial intermediation
02084334496 Despite me blocking this number on my telephone, they still attempt to call me daily, even though the number is also logged with TPS!
ben & jerry's homemade ltd. Ice cream manufacturers egham tw20 9ea
8 calls in 1 week - not answered any
robert christopher unisex hairdressers cobham kt11 2lr
wise underwriting agency ltd london act auxilliary financial intermediation
george a pickles - livestock and others Keighley
no one there when u answer
restaurants birdcage restaurant folkestone
alpha financial consultants ltd london finance / banking
stpatrick's trian tourist information armagh county armagh
Always calling.
Argos customer service
sports clubs m e b sports & social club tipton
bharatiya vidya bhavan limited london operation of arts facilities
Do not generally answer calls from a number not in my contacts list; but answered the call as expecting a call from Get Into Teaching (Dept of Education). The call was disconnected as I said "hello". Very suspicious behaviour of a government agency who col
Same. Text with my name in it offering me a £200 ysl hamper to review and keep. Can't even block the number from my phone.
Asked for me by name as "I entered a competition for an Iphone X". Massively aggressive and rude when informed he was talking BS.
|Model: LG Spirit (LG-H422)
|processor: 1.3GHz quad-core
|Internal storage: 8GB
|Rear camera: 8-megapixel
|Front camera: 1-megapixel
|Screen size: 4.70
|Resolution: 720x1280 pixels
|dimensions: 133.25 x 66.12 x 9.95


text:
Social Question
Would you pay money to destroy a symbol of a repressive organization? [Detail]?
Asked by ibstubro (18765) June 24th, 2016
A woman came into the antique mall today and asked about a Nazi armband displayed in a case. It was $75. She asked the best price and was told $67.50, and said "I'll take it!"
Te armband was carried to the counter. She paid for it, then asked for a pair of scissors and shredded the armband.
Is there value in destroying an artifact from the Nazi's? The KKK?
Would you pay to destroy something from a particular organization?
How much, and what group?
Observing members: 0 Composing members: 0
15 Answers
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text:
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text:
Mapping the O-glycoproteome Using Site-Specific Extraction of O-linked Glycopeptides
The Tn-antigen is characterized by the presence of a single N-Acetylgalactosamine (GalNAc) residue linked to serine or threonine residues on proteins. It is an immature glycoform without extension to form any of the common O-glycan core structures. The Tn antigen is a hallmark of many forms of cancer and rarely found in healthy tissue. Mapping and comparing Tn-antigens on proteins is therefore of great interest but current methods are laborious and inefficient.
Scientists at Johns Hopkins School of Medicine have developed an ingenious new approach for mapping Tn-antigens from a number of complex samples (Yang et al 2020a). It is based on a technique called ExoO (Yang et al 2018) where tryptic peptides are covalently immobilized on a solid support and digested with OpeRATOR®. As this enzyme can only digest when an O-glycan is present, this results in the specific release of O-glycopeptides which can be analyzed in-depth using LC-MS.
However, OpeRATOR does not digest at sites modified with Tn antigens. To circumvent this limitation, Yang et al. first treated their samples with recombinant C1GalT1, an enzyme able to elongate the Tn antigen into a core 1 structure (Gal-β1,3- GalNAc). Sites modified with core 1 O-glycans are efficiently digested by OpeRATOR and can therefore be mapped in depth using EXoO and LC-MS. To distinguish the Tn-antigen sites from naturally occurring core 1 glycosylation sites, the C1GalT1 reaction was performed in the presence of a heavy isotope labelled donor substrate (13C-UDP-Gal). This introduces a unique mass signature that specifically marks the Tn-antigen sites and is easily detectable by mass spectrometry. Using this new approach, termed EXoO-Tn, Yang et al. were able to identify an approximately 10-fold higher number of Tn-glycosylation sites compared to previous studies.
Link to paper, Yang, W. et al., 2018. Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO). Molecular systems biology, 14(11), p.e8486.
For a detailed description on how to use OpeRATOR for in-depth mapping of O-glycosylation sites using the EXoO workflow, check also this recent publication in Nature Protocols (Yang et al 2020b)
Easy IgG Isotype Fingerprinting with FabRICATOR® and Ion-Mobility MS
Researchers at Strasbourg University and Pierre-Fabre highlight the benefits of a middle-level approach to IgG isotype fingerprinting using native ion-mobility mass spectrometry.
In this new article by Botzanowski et al., a middle-level approach was compared to more classical intact methods for distinguishing IgG isotypes using native ion mobility mass spectrometry. Ion mobility mass spectrometry and collision induced unfolding (CIU) at the intact level is hampered by minimal variations that can be observed. The authors used FabRICATOR to digest adalimumab, panitumumab, and natalizumab down to Fc/2 and F(ab')2 domains. The Fc domain provided only limited isotype information due to sequence similarity. However, the stability profile of F(ab')2 and its' unfolding pattern measured by CIU uncovered very clear differences between the isotypes that could not be achieved with full length, intact mAb.
Eculizumab, a humanized IgG2/4 hybrid, which gives conflicting isotype patterns using classical approaches, was also tested. With the middle-level CIU approach, eculizumab could be easily distinguished from reference isotypes. In summary, the authors clearly show how easy, reliable and clear-cut classification of mAb isotypes can be achieved using a middle-level approach with FabRICATOR digestion.
The full article is available here:
Botzanowski, T. et al., 2020. Middle Level IM-MS and CIU Experiments for Improved Therapeutic Immunoglobulin Subclass Fingerprinting. Analytical Chemistry. 10.1021/acs.analchem.0c00293
GlyCLICK® and Middle-up LC-MS Enables Robust ADC Development
Scientists at the University of Geneva and CNRS present site-specific ADCs generated using the GlyCLICK technology and an analytical middle-up LC-HRMS workflow as a potential core module for ADC development.
Antibody-drug conjugates (ADCs) are efficient therapeutic agents that possess the cell-targeting properties of monoclonal antibodies combined with the potency of cytotoxic drugs. Early generation ADCs were predominantly obtained through non-selective conjugation methods by incorporation of a drug payload at randomly distributed sites. Such methods result in highly heterogenous subpopulations of varying antibody-drug ratio (DAR) leading to potential loss of efficacy and impaired pharmacokinetics. While alternative strategies exploring genetic engineering have emerged for conjugation at non-natural amino acids, challenges related to both production and analytical characterization persist.
Glycan-mediated bioconjugation using the GlyCLICK technology is an attractive option to overcome the challenges of conventional bioconjugation without the need for genetic engineering to produce custom ADCs. By utilizing a unique combination of enzymes, the conserved Fc-glycans are remodeled and site-specifically conjugated using click chemistry for ADCs carrying two payloads per antibody (DAR=2.0) having controlled drug stoichiometry and preserved immunoreactivity. In this paper, Duivelshof et al. developed a site-specific ADC by coupling trastuzumab to DM1 using the GlyCLICK technology and evaluated the quality of the conjugation process using complementary reversed phase (RPLC) and hydrophilic interaction chromatography (HILIC) coupled to high-resolution mass spectrometry (HRMS).
The trastuzumab antibody was site-specifically conjugated to DBCO-functionalized DM1 (DBCO-PEG4-Ahx-DM1) using the GlyCLICK technology. To reduce sample complexity, the antibodies were digested with FabRICATOR® (Ides) or FabALACTICA® (IgdE) and reduced for comparison of native and GlyCLICK conjugated trastuzumab at the subunit level. The complementary HILIC and RPLC workflow allowed the authors to observe the significant shift in retention between the lipophilic drug payloads on the ADC and the hydrophilic N-glycans on native trastuzumab. These results enabled the scientists to confirm site-specific conjugation at the Fc-glycans sites, while hyphenation to HRMS detection allowed accurate determination of a DAR of 2.0 for GlyCLICK conjugated trastuzumab, which was not possible at the intact ADC level.
"Most ADCs are produced with non-selective bioconjugation of drug payloads to lysine or cysteine residues creating a wide variety of drug-antibody ratios (DAR). In the frame of new ADC product development, we believe that having control over the DAR and drug load distribution (DLD) is of crucial importance, as is the ability to accurately monitor these two CQAs. Therefore, the combination of the GlyCLICK technology to create homogeneous site-specific ADCs with the middle-up LC/HRMS approach to rapidly determine both the DLD and DAR has a great potential for ADC development."
Duivelshof et al., 2020. Glycan-mediated technology for obtaining homogenous site-specific conjugated antibody-drug conjugates: synthesis and analytical characterization by using complementary middle-up LC/HRMS analysis. Analytical Chemistry. doi: 10.1021/acs.analchem.0c00282
FabRICATOR® in complete characterization of seven therapeutic monoclonal antibodies
Monoclonal antibodies (mAb) are used in various treatments and new potential targets continue to arise. To ensure a high specificity of the antibody to the intended antigen each mAb needs to be well characterized since they are often heterogeneous. In this paper, Giorgetti et al. combined bottom-up, middle-level and intact level analysis to get the complete structure of seven mAbs with worldwide approval. For the middle-level analysis, FabRICATOR digestion followed by a reduction step was the preferred approach.
On-line capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) compatible with all three levels of analysis was used for the characterization. The overall heterogeneity and high mass post-translational modifications (PTMs) were determined at the intact level. Confirming the results, the middle-level approach expanded on this with more advanced PTM data and information about the backbone structure. Finally, bottom-up analysis provided the precise location of the PTMs and the relative quantity of micro-heterogeneities in the proteoforms. However, while bottom-up data provided the most detailed information it required the most sample preparation which might lead to artifacts. The intact and middle-level analysis avoided this problem. Therefore, the research group suggested that a combination of the three levels efficiently analyzed with CE-ESI-MS was ideal for a representative, complete characterization of the structure of the mAbs.
For middle-level analysis the mAbs were digested with FabRICATOR yielding F(ab)'2 and Fc/2 fragments of about 100 kDa and 25 kDa. This allowed PTMs such as methionine oxidation and lysine clipping to be observed. The N-glycan profile was also determined. Reduction of the F(ab)'2 fragment to light chain (LC) and Fd fragments further reduced complexity to make small PTMs such as asparagine deamidation detectable. In addition, the speed and efficiency along with the high accuracy was appreciated by the researchers.
Giorgetti et al., 2020. Combination of intact, middle-up and bottom-up levels to characterize 7 therapeutic monoclonal antibodies by capillary electrophoresis – Mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2020, 182, 113107. https://doi.org/10.1016/j.jpba.2020.113107
IgGZERO® used to determine the core fucosylation of antibodies in bioprocess
Scientists at NIBRT in Dublin together with scientists at the University of Manitoba, Winnipeg, have investigated the effect of two different methods to control the level of fucosylation of a model antibody during expression in CHO cells.
Production of biopharmaceuticals in mammalian cells requires that critical quality attributes are controlled for safety and therapeutic efficacy. The efficacy of an IgG antibody for cancer immunotherapy is dependent on its ability to elicit effector functions such as antibody-dependent cell cytotoxcicity (ADCC). The absence of fucose on the core GlcNAc of the Fc glycan in the antibody increases the ADCC and hence there is a desire to control the level of fucosylation during the manufacturing process.
The model antibody investigated in this work was a camelid heavy-chain human Fc fusion of about 80 kDa in size. During expression of the antibody in CHO cells, two factors were were evaluated: the effect of adding a fucosyltransferase inhibitor and the impact of overexpression of a gene that deflects the fucose de novo pathway to a dead-end. The antibodies were harvested from the cell culture supernatant by a protein A column. The N-glycans of the antibodies were then released using PNGaseF, labelled with 2-AB and analyzed by HILIC-HPLC. The fucosylation pattern of the antibodies was identified by electrospray ionization mass spectroscopy (ESI-MS) of the intact control antibody after treatment with IgGZERO (EndoS). Hydrolysis with IgGZERO results in three possible antibody variants with two, one or no fucose per antibody. Since IgGZERO specifically removes the Fc glycans leaving the core GlcNAc (+/- fucose), the observed shift in mass of -146 Da and -292 Da revealed antibody species where one or two fucoses were missing. Using this approach, it was shown that the inhibitor for fucosyltransferase decreased the addition of fucose on the inner GlcNAc during the expression of the antibody in a concentration dependent manner.
By combining data from the released glycan analysis with the mass data of intact antibody after IgGZERO treatment, crucial information about the glycan profile and fucosylation pattern was revealed and evaluated to support the bioprocess design.
IgGZERO® Turns a Toxic Antibody into a Novel Treatment for Sepsis
Genovis SmartEnzyme IgGZERO was used in this recent study by researches from the University of Pennsylvania and the Philadelphia Children's Hospital.
Sepsis is a dysregulated immune response to an infection that leads to very high levels of inflammation resulting in tissue damage and potential for multiorgan failure. It therefore leads to a high rate of mortality and morbidity. Neutrophil extracellular traps are part of the innate immune systems defence against infections where neutrophils rupture and release DNA, histones and many antimicrobial proteins. This however comes at a cost as NETs are degraded by circulating DNase and toxic degradation products are formed.
In a recent study published in Blood, researchers from the University of Pennsylvania and the Philadelphia Childrens Hosptial used a monoclonal antibody that binds to NETs to stabilize the traps, therefore significantly reducing the collateral tissue damage induced by NET degradation products. However, the mAb also activated the complement system and platelets, therefore negating the positive effect of NET stabilization. Using IgGZERO, the authors were able to remove the Fc glycosylation from their mAb, thereby impairing its ability to elicit an immune response. The deglycosylated mAb was still able to stabilize NETs and its administration lead to a significantly improved outcome in a murine sepsis model.
Fc glycosylation is a major determinant for which effector functions a monoclonal antibody is able to elicit and therefore its mode of action. Genovis IgG-specific endoglycosidases (GlycINATOR and IgGZERO) provide an easy way to remove the Fc glycans from mAbs.
Gollomp et al, 2020. Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis. Blood, 135(10), 743–754. doi:10.1182/blood.2019002329
Investigating IgG Delivery Across the Blood-Brain Barrier with GlycINATOR®
Scientists from the University of Delaware demonstrate the use of GlycINATOR for studying transcytosis of IgG in an in vitro model of the blood-brain barrier.
Brain endothelial cells (BECs) are important structural components of the blood-brain barrier with a unique physiology that restricts permeability of blood-borne molecules such as therapeutic antibodies to the brain. The neonatal fragment crystalline receptor (FcRn) is known to mediate IgG recycling and transcytosis in peripheral epithelium, but the role of FcRn in transcytosis of antibodies in BECs remains uncertain.
In this paper, Ruano-Salguero and Lee study the role of FcRn in transcytosis of IgG across the blood-brain barrier in BEC-like cells (iBECs) derived from induced human pluripotent stem cells. Using microscopy-based methods, different antibody species and subunits were compared to investigate the role of FcRn on transcytosis of IgG. To specifically determine the impact of Fc-glycosylation on permeability, all glycoforms on human IgG1 was removed using the GlycINATOR enzyme and the deglycosylated antibodies analyzed in iBECs using live-cell microscopy. Finally, the authors also investigated the impact of biophysical properties such as charge and size on transcytosis mechanisms.
Using the in vitro blood-brain barrier model, the scientists found that FcRn mediates both recycling and reduced lysosomal accumulation of IgG in iBECs. Transcytosis of antibodies across the in vitro blood-brain barrier exhibited non receptor-medicated mechanisms that were unaffected by human FcRn-binding motifs and Fc-glycoforms as demonstrated by the different species and deglycosylated human IgG1. Investigations of intracellular trafficking by FcRn binding or other IgG-specific mechanisms were further observed to be non-saturable, indicating fluid-phase permeability. Interestingly, the authors found that biophysical changes enhanced permeability of molecules with positively charged isoelectric points. These results highlight the potential for use of in vitro models as well as characterization and modification of biophysical properties to improve therapeutic delivery to the brain.
Deglycosylation of IgG using the GlycINATOR enzyme decreases binding to Fc-receptors (FcRs) enabling bifunctional assays to study glycan-mediated interactions such as ADCC activity. The binding to FcRn is however preserved with GlycINATOR, allowing recycling and increased circulation in vivo of deglycosylated IgG and GlyCLICK conjugated ADCs.
Ruano-Salguero and Lee, 2020. Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn. Sci Rep 10, 3685. https://doi.org/10.1038/s41598-020-60438-z
Genovis Business Continuity
Genovis continues operation and remain committed to serve our customers during the ongoing pandemic crisis. Manufacturing and distribution of the Genovis SmartEnzymes™ are running according to our business continuity plan to meet our customers' needs and to secure supply.
We are monitoring the situation carefully and will notify you immediately if we experience disruptions in fulfilling customer orders. Genovis is fully committed to providing uninterrupted supply of our products to safely keep your research on track.
With these uncertain times "scientists enabling scientists" takes on new meaning. Toward this goal, we continue to provide convenient online access to our customer service, technical support and sales teams. Should you have any questions or concerns, do not hesitate to contact us at firstname.lastname@example.com.
Most importantly, we hope your staff as well as ours stay healthy and safe during this time.
Fully automated 3D LC-MS workflow for the characterization of antibody glycosylation
Genentech used FabRICATOR®-HPLC to develop a fast and automated 3D LC-MS workflow for the characterization of glycosylation on therapeutic antibodies.
The glycosylation profile is a critical quality attribute of biopharmaceuticals including antibodies. This heterogenous quality attribute can be tackled using a range of different analytical technologies including separation of released glycans , intact glycoprotein mass analysis, subunit mass analysis and many more. An antibody subunit approach using FabRICATOR (IdeS) combined with separation on hydrophilic interaction chromatography (HILIC) offers a promising strategy for characterization of IgG glycosylation. Typically, the FabRICATOR digestion is done manually, offline, prior to LC-MS. In a growing number of cases, like online monitoring of glycosylation, it is desirable to automate such a workflow.
Researchers at Genentech in collaboration with University of Geneva recently published an automated workflow using three dimensional separation coupled to mass spectrometry. To automate the workflow, they employed the FabRICATOR-HPLC column to deliver online antibody subunit generation. In their setup, this was followed by on column reduction and separation of the subunits using a reversed phase column, coupled to HILIC column to separate the Fc/2 glycoforms. In summary, the system incorporated three columns controlled by two valves: FabRICATOR-HPLC x Reduction/RPLC x HILIC/MS (Fig. 1 below).
Camperi et al. compared their automated workflow to the standard manual digestion by testing two of their candidate mAbs. The authors concluded that the 3D automated workflow, which took 95 minutes per sample, could deliver comparable data for all N-glycan variants for the Fc/2 subunit and therefore could be applied to the analysis of not only mAbs but also antibody drug conjugated (ADCs) and bispecific antibodies. Finally, the scientists emphasize that the key strength of the 3D approach was not just the automation aspect but also the fact that no tedious sample preparation was required, and that it is applicable to routine analysis tasks.
Fig 1. 3D-LC Workflow for automated middle-up analysis of mAbs (Camperi et al., 2020.)
Camperi et al., 2020. Development of a 3D–LC/MS workflow for fast, automated and effective characterization of glycosylation patterns of biotherapeutic products. Anal. Chem. 2020, 92, 6, 4357-4363. doi:10.1021/acs.analchem.9b05193
FabRICATOR® presents F(ab')2 PET-tracers for Prognostic Imaging
Scientists at Minerva Imaging demonstrate the use of FabRICATOR® to generate a 64Cu-labeled F(ab')2 PET-tracer for the detection of changes in T Cell response to combined radiation and immunoblockade therapy.
Current immunotherapy response-evaluation criteria are limited in discriminating responsive patients eligible for immunotherapy from non-responders. Accurate evaluations of progression are limited by pseudo-progression, a phenomenon where therapy-induced inflammatory events temporarily increase tumor volume, thereby delaying evidence of response. Routine and standardized clinical evaluations are needed that require predictive biomarkers combined with reproducible methods for monitoring biomarker expression and dynamics.
Targeting T cells as essential players in the anti-tumor immune response, Kristensen et al. developed a 64Cu-labeled F(ab')2 against murine CD8a+ T cells. The scientists further demonstrate its potential as a prognostic PET-imaging biomarker
for immunotherapy response in mouse models of colorectal cancer. Rat anti-mouse CD8a antibodies were digested using the FabRICATOR enzyme to generate homogenous F(ab')2 and Fc/2 subunits. Purification by preparative HPLC yielded isolated F(ab')2 subunits for random chelation with p-SCN-Bn-NOTA and radiolabeling using the 64Cu isotope. Treatment response assessment was conducted using in vivo PET-imaging of tumor-bearing mice subjected to combined radiation and anti-CTLA-4 therapy.
The scientists found that the tumor-to-heart ratio of the PET-tracer increased with combined therapy, this was also confirmed by flow cytometry and IHC analysis showing increased tumor infiltration by CD8+ T cells. The prognostic value of the PET-tracer was further demonstrated using in vivo imaging as the scientists were able to distinguish responsive mice from non-responders prior to treatment-induced variations in tumor volume.
Kristensen et al., 2020. Monitoring CD8+ T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [64Cu]NOTA-CD8a PET imaging. Mol Imaging Biol (2020).


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Woman killed in car-train crash at Rosthern, Sask.
A woman died and three children were injured when a car was hit by a train on Sunday.
The crash happened Sunday afternoon in Rosthern, Sask. Police say the car was on Highway 312 crossing the tracks in town when it was hit by the train.
A 30-year-old woman was pronounced dead at the scene.
The children — all girls from seven to 12 years old — were transported to hospital with serious injuries.
The girls are expected to survive. None of the names have been released.
Police say every indication is that the crossing equipment at the rail crossing, including the lights and the bell, was fully operational at the time of the crash.
The rail line is privately owned.
Rosthern is about 66 kilometres northeast of Saskatoon.


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Typewritten documents.
There are 4,397 related items to this topic
Date: 1 Jan 1903-31 Dec 1903 From: Ward, Basil A, fl 1984-1995 : Diaries of Joseph Ward and members of the Ward family Ref: MS-Papers-5115-07 Description: Diary gives details of farm and family life in the Nelson-Marlborough district Quantity: 1 folder(s). Physical Description: Typed transcript (photocopy)
Date: 9 Apr-15 May 1915 From: Stichbury, Vincent John, 1891-1966 : Family papers and World War One diaries Ref: MS-Papers-11559-01 Description: Folder contains two typed transcripts (original and carbon copy) of Stichbury's 1915 World War One diary. Records daily entries for most of April and May. De...


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196x Remington Mark II #1384709
Status: My Collection
Created: 03-27-2020 at 12:10AM
Last Edit: 04-27-2020 at 11:02PM
I've had this thing for many years, mostly because I can't get rid of it. I've taken this thing travelling across the country back in my tramping days, its been used heavily and abused mercilessly but still works perfectly well.
Typeface Specimen:
Hunter: Trevor London (NoiselessBastard)
Trevor London's Typewriter Galleries [ My Collection ] [ My Sightings ]
RESEARCH NOTE: When researching the Remington Mark II on a computer with lots of screen real estate, you may find that launching the Remington Serial Number page and the Remington Mark II By Model/Year/Serial page in new browser windows can give you interesting perspectives on changes throughout the model series.
Vintage Remington Mark II Cursive Script Typewriter With Locking Case
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140 Funny Comics About Winter Problems That Almost Everyone Will Relate To
For those who live in cold places (looking at you, Canada) winter can be an ordeal. We all know that it's coming and we all find our own ways to deal with it, some better than others.
Here at Bored Panda we have compiled a list of hilariously relatable comics that perfectly illustrate the struggles of winter, from the mundane worries of trying to look fashionable while wrapped up in a coat the size of a mattress, to the more serious issues of winter depression and pretty much freezing to death. For our readers in the southern hemisphere we also have the classic summer problems, because we understand that it can be tough at this time of year down there too.
Scroll down to check out the list below, and feel free to add your own winter struggles in the comments!
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It's not as bad as my jeans thinking my crotch is in my belly button.
The sun is really busy during winter time! I'm living in north of France, here it's 10:40 am, I'm at work and the sun didn't show up yet...
even the "can u come to my party" is hidden...
I didn't even notice that...how did you..?
When i was at school...A ''while'' ago..I'd receive Christmas cards with ''PS....Happy Birthday'' along the bottom.... So yes,you're right.Load More Replies...
I'm born in December but I actually just get more presents than everyone so I'm happy hehe thanx mum and dad
That is parenting done right.Load More Replies...
My birthday is at Christmas and every year i seem to age but not actually have a birthday. Every year,for as long as i can remember,we went to relatives to hand out Christmas presents on MY BIRTHDAY, and then i'd be greeted with..'''Oh yes,it's your birthday isn't it..'' GREAT. :(
Christmas birthday right heeeeeere!!! December 25. I love it. It's special. And I was never screwed on gifts, in fact everyone remembers my bday, so I get gifts from relatives that my sister never would.Load More Replies...
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Check your privilege girl. Count those blessing that you even get presents.
I was referring to when I was a child...As an adult,things are very different.
Excuse me while I go scream.
Had a friend who's birthday was on December 24th. And then her parents thought it would be great to name her Eva... That's just evil! :(((
To clear it up - here in Sweden we have "namedays" and Eva is the name on Christmas eve...Load More Replies...
thanks from all of us December babies.
I know this pain....
Add January and you nail it. Hell, add November for the real cheapos
I've never been so happy
Im the 20 th yaaay
26th December.
December 27th and I can relate. A lot of people think it would be fun but in reality it kinda sucks.
Mine's Boxing Day...And I agreeLoad More Replies...
Story of my childhood....
Story of mine too...Plus every single birthday i can remember..Load More Replies...
My friens has birthday 27 Dec and in this year is her 18th birthday. Party is on 26Dec.. Imagine leaving your family on a second day of Christmas to go to another city for a party lol
My nephew's is December 24th. Yeah.
My birthday is on 29 December. While I was a child my birthday was celebrated together with my eldest brother, whose birthday is on 31 December. = (
If I have a kid in December I'll nominate a more advantageous date to hold the celebration. They can just lie to everyone about when their birthday is (obvs not official forms).
Clever, very clever picture!
How true!
My birthday is in January ! Lucky me
I relate
So true. It was great when I was younger and everyone went to the pub on Christmas eve (my birthday)
My momma birthday is on Dec 10 and we always have a birthday party separate from Christmas.
My birthday is in December and I'm getting at that age where I'm kinda glad people forget about it.
No, it's in January :P Same shit...
"It's my birthday..." "Oh really? Merry Christmas!!!"
Well been there-done that 😊. But you still have a whole year to get used to your age 😉. You are alvays a year younger than those born in january the same year 😀😁😂
This happens to me ALLLL THE TIME
5 days before Xmas as a kid DOUBLE PRESENTS !!!! but as you get older every one gooses straight o Christmas
My best friend/8 months older sister's birthday was today!
Does this remind anyone of Diary of a Wimpy Kid? In book 5, Cabin Fever Greg Heffley (the main character) says that he feels bad for people whose birthdays are right around Christmas because they get cheated out of a gift.
or early January
C'est trop vrai !!!!
25th December...and yes, same here. Anyway, when I was a child my father used to give me a present on a random day (NOT in December) for my Non-Birthday! Most relatable invitation ever o_O
19th december here, I know the feeling... Let's not forget the usual "you'll have a bigger present, but it will be for your birthday AND christmas". Nope, never happened :D
one of my friend's birthday is at Christmas at 12 am. They celebrate is at lunch, then celebrate Christmas in th evening. It means one big present for the two every year.
We did it this year at work, I received a Star Wars kit with glass and cup... I don't like Star Wars... Am I the weirdo? :o
Where I live: "Whoa, a snowflake! Must drive 3 km/h!!!!" *panicking*
That was me as a child. Now most of my family knows that I'm too picky to buy clothes for, but you know that kid mentality: "What do you mean it's not a toy!?" My grandpa used to give my brother and I cheques specifically to go into our accounts for school (like college/university school), I understand the purpose now but he gave them TO US AS CHILDREN! You give that to the parents! No kid wants a card full of money they can't use!
No,you're not 'getting fat'....You're ''insulating yourself'' from the cold weather....That's what i keep telling myself anyway..
That's true. And this oscilation between extreme temperatures is the main reason we get those stupid winter colds.
The house I lived in with my mum and brothers was an older house, didn't have very good insulation and only had heating downstairs, so I grew up like that, always cold in winter, having to wear multiple layers at home. At some point (when I was around 18 and had moved to the attic for more space) we got a heater for in our rooms. I hated having to be sparing with it though. Now I have my own place WITH heating everywhere xD Never been happier about heating lol. I still wear a sweater at home but I'm not gonna wear 10 layers to be comfy so I just turn up the heat :D


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Hessarghatta, Hyderabad Dhulapally Road, Hessarghatta, Hyderabad - 500014, Dist. Hyderabad, Telangana
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Tswastha Nature Cure & Yoga
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G Spa
Redhills, Hyderabad Floor Number 10, Banjara Hills, Gauri Shanker Colony, Sai Baba Temple, Redhills, Hyderabad - 500034, Dist. Hyderabad, TelanganaCall +91-9676184711
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Palm Exotica
Hyderabad Sy.No.125, Parveda Village, Shankarpally, Ranga Reddy, Hyderabad - 501203, Dist. Hyderabad, TelanganaCall +91-7702500222
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Banjarahills, Hyderabad Shop No. 1, Ground Floor, City Center Mall, Road No. 1, Banjarahills, Banjarahills, Hyderabad - 500034, Dist. Hyderabad, TelanganaCall +91-9959555444
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Manicure is a cosmetic treatment of the Hands involving shaping and often painting of the nails, removal of the cuticles, and softening of the skin.
The Axnis Hair & Beauty Salon (Ladies only)
Nizampet, Hyderabad Plot No.314, 315 & 316, Sumanth Sai Palace, Shop No.3, Bandari Layout, Near Gram Panchayat, Nizampet, Nizampet, Hyderabad - 500090, Dist. Hyderabad, TelanganaCall +91-9441414768
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madhapur, Hyderabad madhapur, madhapur, Hyderabad - 500081, Dist. Hyderabad, TelanganaCall +91-9703811221
Swedish Massage
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- White Derma Glow Face Massager, Full Body
Rs 3,500/ UnitGet Latest Priceread more...
Target Location: Full Body
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Bhagyalaxmi Industries
ECIL, Hyderabad 51, Electronic Complex Extension Kushaiguda, ECIL, Hyderabad - 500062, Dist. Hyderabad, Telangana
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- Summer Cleanup 5 In 1 Face Massager
Rs 448/ summerGet Latest PriceSpecifications: Exfoliating of dead skin cells to reveal a roseate , youthful skin. Massage and application of cream to better penetrate the skin and keep it nourished and hydrated. Removing hard cells under foot or elbow. Battery Replacement Important: If the unit is to be disposed for long time, make sure to take outread more...
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- Women Wahl Head To Toe Confidence (Purple)Ask Priceread more...
Gender: Women
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Salonlo Cosmetics
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The Relax & Spin Tone is an effective, light weight and portable device capable of targeting specific areas of the body. Its unique oscillating feature penetrates deeply into the inner layers of the skin for muscle toning and deep tissue massage. The 360 degree
Acupressure Health Care Systems
Kachi Guda, Hyderabad Shop No. 3-2-1/5, Kumar Talkies, Near Shyam Mandir, Station Road, Kachiguda, Kachi Guda, Hyderabad - 500027, Dist. Hyderabad, Telangana
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Kothaguda, Hyderabad Ektha Pearl,Above Ratnadeep Super Market Kothaguda, Kothaguda, Hyderabad - 500028, Dist. Hyderabad, Telangana
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Beauty parlors near you for Bridal make-up, party make-up. Visit our site and find the best service provider.
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Rs 1,500/ HourGet Latest Pricemassage
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Gachibowli, Hyderabad Shop No. 4-41, Gachibowli, Hyderabad - 500034, Dist. Hyderabad, Telangana
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- Deep Tissue MassageAsk PriceDeep Tissue Massages have been in practice for a long time, now. O2 Spa specializes in this massage to relieve the stress and strain from the clientele's body and mind.read more...
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- Classic manicureAsk PriceThe pedicure which will remove all your dead cells, softning your heel, clean up your cuticle area and a wonderful foot massage that improves your blood circulation followed by nail polish.
Manik Salon
Jogani, Ramgopalpet, Secunderabad, Dist. Hyderabad No. 1-8-153/153/a, Shivasadan Apartment. P.g Road, Innovation Colony, Jogani, Ramgopalpet, Jogani, Ramgopalpet, Secunderabad - 500030, Dist. Hyderabad, Telangana
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- Deep Tissue MassageAsk PriceUsed to release chronic muscle tension through slower stroke and more direct deep pressure or friction opplied across the grain of the muscles. Added benefitt include releasing toxins from muscles and get blood and oxygen Circulating properly
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Isa Spa
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Ever Young Services
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text:
The Dow's pain was a boon for most of the Treasury market today.
Down rather sharply early in the session, the benchmark 10-year Treasury note and shorter-maturity issues moved into positive territory once the
Dow Jones Industrial Average
factored in the far-fallen price of
Procter & Gamble
(PG) - Get Report
and never looked back.
But the erstwhile benchmark, the 30-year Treasury bond, ended lower despite the
Treasury Department's
announcement of details of its plan to buy some of its securities back from investors.
Today's only major economic report, the revision to fourth-quarter
productivity and unit labor costs
numbers, was better than expected. Nonfarm business productivity rose at a 6.4% rate during the fourth quarter, the
Bureau of Labor Statistics
reported, not 5.0% as originally estimated. That is the fastest pace since the fourth quarter of 1992, when productivity rose 7.4%. Economists polled by
had forecast a pace of 6.3% on average.
Unit labor costs, which moderate when productivity accelerates, fell at a rate of 2.5%, not 1.0% as first estimated. That's the biggest decline since the fourth quarter of 1992, when unit labor costs fell at a 3.9% rate. The consensus forecast was for a 2.2% decline.
Historically, both the stock and bond markets have rallied on improving productivity and unit labor costs data. But in his
testimony last month,
Alan Greenspan
suggested that from a bond-market perspective, rising productivity has a dark side.
Because it makes investors willing to pay higher prices for stocks, rising productivity encourages consumer spending in excess of the economy's current ability to produce, even as it works to keep the economy from overheating. That is potentially inflationary.
"The problem is that the pickup in productivity tends to create even greater increases in aggregate demand than in potential aggregate supply," Greenspan said. "This occurs principally because a rise in structural productivity growth has its counterpart in higher expectations for long-term corporate earnings. This, in turn, not only spurs business investment but also increases stock prices and the market value of assets held by households, creating additional purchasing power for which no additional goods or services have yet been produced."
So the bond market shrugged off the productivity revisions, even dropping some as the
futures rallied.
Then, at 9 a.m. EST, the Treasury Department announced that its first debt buyback in 70 years will take place on Thursday. Acting through the
Open Market Desk
of the
New York Fed
, the department will buy up to $1 billion of 30-year bonds maturing between February 2015 and February 2020. The department had previously announced that it would buy back up to $30 billion of securities this year, in increments of about $1 billion.
The buyback program is one of the ways the Treasury Department is dealing with the federal budget surplus, which reduces its need to issue bonds. Simply reducing new issuance has the disadvantage of impairing the liquidity of Treasury securities.
From that point on, though, the action was "all about the Dow,"
Warburg Dillon Read
Treasury market strategist Mark Mahoney said. "It helped fives and 10s, which have been stinking up the place the last couple of days, get a better bid," he said, referring to the five- and 10-year notes.
Money sometimes flows into the Treasury market when stocks sell off on the theory that a sustained decline in stock prices has the potential to limit the amount by which the Fed will raise the
fed funds rate
in the coming months.
At the same time, though, the rally in oil continued, lifting its price to a new multi-year high, with negative implications for inflation and thus for the interest-rate outlook.
The benchmark 10-year Treasury note, which traded down as much as 10/32 this morning, ended up 10/32 at 100 30/32, trimming its yield 4.3 basis points to 6.371%. The 30-year Treasury bond, down as much as 20/32 after the buyback announcement, ended down 2/32 at 101 12/32, lifting its yield a fraction of basis point to 6.148%.
At the
Chicago Board of Trade
, the June
Treasury futures contract fell 2/32 to 94 25/32.
Economic Indicators
Also today, the
BTM/Schroder Chain Store Sales Index
rose just 0.1% in the first week of March. The
Redbook Retail Average
fell 0.3% during the first week of March relative to February.
Currency and Commodities
The dollar fell against the yen and gained against the euro. It lately was worth 106.17 yen, down from 107.43 yesterday. The euro was worth $0.9589, down from $0.9592 yesterday. For more on currencies, please take a look at
Currency Watch column.
Crude oil for April delivery at the
New York Mercantile Exchange
hit $34.13 a barrel, up from $32.18 yesterday.
Bridge Commodity Research Bureau Index
rose to 215.61 from 214.49 yesterday.
Gold for April delivery at the
reached $293.70 from $289.40 yesterday.


text:
FARMINGTON — Anybody speak Guarani, or know where someone can get a decent cup of terer� in this town?
These are the questions one might expect to be asked by a visitor to Farmington from the South American country of Paraguay, and by 2013, Nicole Levesque will be able to assist.
Right now, though, Levesque is about to fly down to Paraguay, learn that ancient tribal language and sip terer� most afternoons as social custom demands — all as part of a 27-month commitment to the Peace Corps. She leaves on Feb. 8 for Miami, Fla., where she will meet up with other Peace Corps volunteers. From there, they fly to Sao Paulo, in Brazil, and on to Asunci�n in Paraguay.
Levesque, 23, who grew up in neighboring New Durham and attended Kingswood Regional High, graduated from a Florida college in 2008 with a bachelor's degree, majoring in psychology and minoring in special education. During her college years, she was inspired by a Peace Corps speaker who visited her campus, and from then she made it her goal to get accepted for an overseas posting. To further this aim, she spend a year in Asheville, N.C., as an intern in a residential treatment facility, working with children ages 7 to 18 with emotional and behavioral problems.
Now, accepted into the Peace Corps, she has been assigned to an urban development project and will work with high-risk Paraguayan youngsters, many of whom drift into urban areas at an early age, detached from their families.
As a prelude to working in a barrio teeming with youngsters (40 percent of the country's 7 million people are under age of 15), she will spend 11 weeks in the town of Guarambare, an hour's bus ride north of the capital, Asunci�n, ferociously brushing up on her Spanish and learning Guarini — the latter, language, in particular, being spoken by just about everyone in the country. Interestingly, several English words derive from Guarani, including tapioca, toucan and jaguar.
Levesque, like all trainees, will live with a Paraguayan family near Guarambare, and will share local meals, talking entirely in Spanish and growing scraps of Guarani the while. Then, when she is given her assignment, she will also live with a local family — at least for the first six months of her two years — in order to facilitate her integration into the community.
The Peace Corps has around 180 volunteers serving in Paraguay, and since 1967, when the program was first set up there, some 3,000 United States volunteers have assisted in the country's development in various fields.
Some of the challenges Levesque will be dealing with are high school drop out rates, housing problems, drug use, crime and unemployment — all of which may sound familiar to American ears. On top of this, though, are other hurdles like illiteracy, poor sanitation, explosive population growth and very limited budgets.
Her initial Peace Corps package, which congratulates Levesque on being accepted to the program, goes on to offer firm advice on the need to dress conservatively and avoid shorts, flip-flops and tank tops, hide any tattoos, and not wear earrings. Laptops and cell phones are also strongly discouraged, as such items could be a beacon for criminals.
These words of caution have not dampened Levesque's spirit in any way.
"I get more excited as it gets closer," she said, as she makes her goodbyes to family members and friends in the area.
She does admit that, over the next two years, she will particularly miss her family and her dogs.
The Peace Corps takes care of volunteers' expenses — food, lodgings and the like — and at the end of the 27 months, everyone receives $6,000.
"That will help pay for my master's degree when I get back," said Levesque, whose plan at that point is to attend the University of Colorado. Meanwhile, as someone who prefers chicken, she is preparing herself for a diet of beef, beans and rice, washed down, one supposes, with lashings of terer�.
"Terer� is built into the training schedule, so it is pretty important," she said, grinning.
Farmington woman off to Paraguay for Peace Corps post
FARMINGTON — Anybody speak Guarani, or know where someone can get a decent cup of terer� in this town?


text:
Find the latest therapy jobs in Elkhorn, Wisconsin. Access the newest travel, permanent, and per diem positions through Sunbelt Staffing.
Applying for a job with us is quick and easy. You can choose to either apply directly for job openings on your own or fill out a brief application form and our recruiter will be in contact with you shortly after. If you have any questions or concerns, you can get in contact with one of our recruiters and they'll help you make applying for your dream job as easy as it should be.
Therapy Jobs in Elkhorn, Wisconsin
Find the latest therapy jobs in Elkhorn, Wisconsin. Access the newest travel, permanent, and per diem positions through Sunbelt Staffing.
Seeking a School Based Speech Language Pathologist for a Job in the Elkhorn, WI areaElkhorn, WISchools - SLP Contract 17 days ago
Clinical Fellows Accepted! - SLP Job Available near Elkhorn WIElkhorn, WISchools - SLP Contract 18 days ago
Full-time School Occupational Therapist Job Hiring NowElkhorn, WISchools - OT Contract 24 days ago
School-Based Speech Language Pathologist Job Near Elkhorn, WIElkhorn, WISchools - SLP - CFY Contract 28 days ago
Seeking a School Based Speech Language Pathologist for a Job in the Elkhorn, WI areaApply
I am seeking a Speech Language Pathologist who would be available for a school-based job. This contract position is located in the Elkhorn WI, area.
In this role, the Speech Therapist will be providing services for Elementary students, with mild to moderate disabilities. Responsibilities will most likely include writing IEP's, progress reports, and providing group and individual therapy services. This school district is looking for a self-starter with excellent time management skills. Commute from Elkhorn WI.
Job Qualifications:
- Must have an active WI SLP license.
- Must have a WI DPI
- Seeking candidate with CCC or CFY.
- School-based experience is preferred; pediatrics experience is required.
To apply: For immediate consideration Speech Language Pathologist job in the Elkhorn, WI area, please send your updated resume directly to firstname.lastname@example.com
Please reach out to me about ALL other opportunities for you – Full-Time or Part-Time positions
Joanne Hughes
Sunbelt Staffing - National Hiring Manager
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Testimonials: Our reputation speaks for itself.
We could tell you all about our experience, but we think it's best to let the work speak for itself. Read what our clients and candidates have to say.
Read more


text:
Fall instantly gives me an urge for soup, and nothing does it for me like ramen. There is nothing better than having my head bent over, slurping noodles Continue reading "Did Someone Say Ramen?"
Category: Food
Chocolate Cupcakes with Nutella Frosting
As a child, I grew up watching my grandmother bake. She was one of the sought after bakers from my community. My mom picked up the skill and I later did. We enjoyed vanilla cakes Continue reading "Chocolate Cupcakes with Nutella Frosting"
Five Simple Breakfast Ideas
They say breakfast is the most important meal of the day and it is my favorite meal of the day. I can eat breakfast all day. Continue reading "Five Simple Breakfast Ideas"
Stuffed Peppers
My introduction to stuffed peppers was from a Ukrainian friend many years ago. It was simple, delicious and Continue reading "Stuffed Peppers"
Matcha Latte Cupcakes
There is a level of precision and detail that goes into baking that requires focus. It is exactly this kind of mental gymnastics I like and makes baking a great stress reliever. You forget everything, Continue reading "Matcha Latte Cupcakes"


text:
Not to be Missed: News Update Event
We are pleased to invite you to the next event in the Myanmar-Norway Business Council. The event takes place on 20 October 2016 , at... Read More
On this page we list events of interest to our members and other stakeholders. Members normally get a preferred price for all events organised by the Thai-Norwegian Chamber of Commerce or sister organisations.


text:
Blushing Love Bouquet™
Make her blush from head to toe with this super sweet, romantic bouquet! Featuring soft pink and creamy white blooms, it's the perfect gift for Valentine's Day, a special anniversary - or any day you want to show your love!
Soft pink roses are arranged with delicate Peruvian lilies in a lovely pink mason jar, sure to bring big smiles (and thanks!) with it!
Product ID UFN1858M
Approximately 14" W x 19" H
What People Are Saying
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November 26, 2020
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September 03, 2020
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Danielle Bellai
August 20, 2020
We are so pleased with our order! The flowers are gorgeous and arranged beautifully! We would definitely recommend Evangeline Flowers!
Reviews Sourced from Google