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Having saved all my packs for the community TOTS, I was happy to pull Godin (untradeable) last weekend. I threw him in my squad for Weekend League alongside baby Hierro and was pleasantly suprised by his quality. With shadows over 20k on the market and Godin already at 95 base defending, I opted to go with a catalyst chem style for the +10 pace boost and the passing boost. With 85 pace (catalyst), Godin is just fast enough to deal with the speedsters up top, although several times I was willing him on to get an extra step. In all though, the 85 pace is just enough. In terms of defending, he steps perfectly and has great interceptions. He almost never got caught out in the open field and led my team in tackles. With 97 strength, he wins nearly every ball in the air. I did notice a boost in his passing as a result of the catalyst; his passes were laser-guided and pinged right to feet. Dribbling was average and shooting is a negligible factor. If you are running a Serie A squad or looking for a cheap CB, this card at 80k is a steal, even if he may be outside the meta. My personal highlight with him was playing a guy who was much better than me - nearly the entire game was played in front of my goal, and even though I lost 2-1 in ET, Godin won MOTM as a defender with 6 tackles, at least 3 or 4 blocks, and a goal-line clearance. The heart of Uruguay's defense was rock solid for me all weekend.
- Defending (interceptions, tackling, everything)
- Physicality (strength: wins every header)
- Pacey enough with either catalyst or shadow (not sure about engine)
- high defensive workrate
- not a top tier CB
- max pace is 88 with shadow


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Level 1 -Thermowave One50 = 150gsm fabric weight for cool weather performance
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subset: commoncrawl


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Izhevsk State Technical University
Faculty of Information Science and Computer Engineering
The faculty was founded in 1993.
The dean of the faculty is Mikhail Andreyevich Senilov, Doctor of Engineering, professor.
As part of the innovative development program for 2011-2015 the faculty provides training, retraining and advanced training in the IT area for 'Rostec' employees.
The educational work is conducted in the following areas: information science and computer engineering, computer mathematics, system and application programming, computer systems and networks, operating and programming systems, databases and workbenches, system analysis and computer simulation, decision making and management, data processing systems and artificial intelligence.
- Department 'Computing technology';
- Department 'Automated data processing and management systems';
- Department 'Software';
- Department 'Information security systems and technologies';
- Department 'Intellectual information technologies in economy'.
Izhevsk State Technical University is of great significance for a number of 'Rostec' enterprises, located in Udmurtia ('Concern Izhmash' OJSC, FSUE 'Izhevsky mekhanichesky zavod', 'Sarapul Electric Generators' JSC, 'NITI Progress' JSC). Izhevsk State Technical University trains skilled personnel and conducts promising researches together with Rostec.


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BENEFITS AND CHALLENGES ASSOCIATED WITH USING STRATEGIC ALLIANCES Over the past years, strategic alliance has been seen as an expansion in globalization and is a known device/mechanism used in the global market by different firms, which is widely accepted. Most leading companies have used different alliances to improve their resources better than their competitors. Strategy involves planning for the future, is a direction for achieving long term profit through its capabilities and competence. Strategy
The identification and the discussion of the foreign market Starbucks should enter will be presented, along with the strategy it should use to enter the market. Challenges Starbucks may face in the foreign market will be discussed, as well how it might respond strategically to minimize the impact of these challenges. Also, this paper will encompass a scenario when it would not make sense for Starbucks to diversify or expand into a foreign market and how the company will create a business environment
crucial system in ensuring the economy is at a stable growth level. With a majority of this activity stemming from family controlled or managed businesses, the focus on developing a global and long term perspective for these firms are ever growing in importance because of the global perspective entrepreneurship has started to take. A family business refers to a company where the voting majority is in the hands of the controlling family; including the founder who intend to pass the business on to their
Introduction and Where We Are Now General Mills, Inc (GMI). produces and markets branded consumer foods globally. They also supply branded and unbranded food products to the foodservice and commercial banking industries. It offers ready-to-eat cereals, refrigerated yogurt, ready-to-serve soups, dry dinners, shelf stable and frozen vegetables, refrigerated and frozen dough products, dessert and baking mixes, frozen pizza and pizza snacks, grains, and fruit and savory snacks; a range of organic products
external information about facts that could influence an organization on its' strategic decision-making process. It is a method of analyzing relevant gathered information and use to determine strategic and premeditated action on the business environment. The environmental scanning process seek obtain both realistic and subjective information on the business environments where a corporation is functioning or considering entering. It is the possession and use of information concerning events, trends, and
management and other executives of the organization. Planning and organizing Planning and organizing is another vital quality needed for managers. If manager can do effective planning he can really contribute in the long term progress and development of his organization. Proper planning helps in useful and efficient use of the existing resources of the organization. After planning if you are not able to organize the things, this can really worsen your planning. Manager should be a team man Successful
macroenvironment of the foreign market. Companies usually decide to expand their market to grow their revenue in an untapped market, however, before doing so, the obstacles that are not typically encountered in the domestic market should be taken into account. According to Hansen (2013), the understanding of the foreign market before expansion is important as it helps understand the potential and future direction of operations. The understanding of a foreign market is prioritized in order to reduce
project due to the various groups of people from different countries being involved in it such as the Nigerian and South African's that form part of the Dangote enterprise. International organizations have a high intake and a high output of information. The value of knowledge sharing has been recognized by most international and supranational bodies of knowledge and as such they have set up information and knowledge management programs. Many organizations consider information management as part of
Wal Mart: Strategic Planning Introduction Wal-Mart is a brand that is well known around the world, especially in the USA. It has gradually developed into the largest retailer in the world. Wal-Mart's globalization efforts have been happening rapidly. But have they been successful in all aspects of their international expansion or not? This is the main thought that is going to be discussed in this essay. The questions I will be looking at are based on a case called "Wal-Mart takes on the world"
The automotive industry constitutes one of particular importance in today's societies. Over the past 50 years, automobiles have allowed people to live and work in ways "that were unimaginable a century ago" (Hwang, 2014). Automotive vehicles are "fundamental to a functioning global economy and to the well-being of the world's citizens" (Hwang, 2014) while it also plays a key role in the technology level of other industries and of society (Hwang, 2014). A large part of the world's population is employed


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Mobile applications are a fantastic new tool that can be used by businesses in a number of ways to accomplish a variety of different results. From improving existing customer loyalty to increasing your social media presence, the outcome depend how your application is designed and how this app is then promoted to your customers. Turning infrequent customers into raving fans is a good method for businesses to enhance their main point here and this is achievable through a well-designed and well executed mobile app campaign.
Once your app is in your customer's phone only 1 / 2 of the work is complete. You've to ensure that the app provides rich, rewarding content for your web visitors to keep them coming back. The kind of content will depend heavily on the kind of business you run but you should have a good notion of what will interest your target demographic. Something that individuals are universally interested in is special offers and discounts. Ensure that you include some exclusive offers to app users every now and then, and make fully sure your customers know you will undoubtedly be doing this reward stamp app. This will keep them engaged and help to keep your app on the phone. It doesn't have to become a massive reduction just enough in order for them to feel they are finding a better deal than everyone else.
In app loyalty cards may also be an effective way to boost customer loyalty through mobile applications. These may be integrated with a QR scanner so that each and every time an individual makes a purchase they receive a virtual stamp, then after so many purchases they will receive a free of charge item, or a portion discount off their next purchase. This works well for transactional businesses such as cafes or juice bars as decisions regarding which of the places a client attends depends heavily on locational proximity, however if your business offers this and the business next door does not guess who will obtain the sale?
Updating the application on a regular basis with fresh content may also keep people checking in. This works great for places like beauty salons or gyms who can provide their clients with free information. This might be on hairstyling tips or new season looks for a beauty salon or workout of your day programs for gym clients. People love free content and if you can provide them with that in an easy to use format that's easily accessible such as through a mobile application, you'll have one up on the competition.
It pays to think about the manner in which you will turn infrequent customers into raving fans before you have your mobile application developed. Decide which strategies you wish to use based on what type of business you have, how your competitions interacts with its clients and also how your clients currently connect to your brand. This will provide your mobile application developers with the blueprint they have to develop an effective customer loyalty building mobile application.


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Kusaba 【草場】5 The Japanese surnames etymology dictionary.
Gunma-ken , Shizuoka-ken , Kanagawa-ken . Occupation . Variant of the 監物 . 監物 reference. Gunma-ken Takasaki-shi It was during the Warring States period as a vassal of Mr. Nagano who was the castle owner of Minowa castle in Minoucho cho. Chiba-ken Minamibousou-shi Wada town In Shiba tell Kanagawa-ken Odawara-shi that he came to live in 1180 (4 years old) after the battle of Ishibashi.
※ Gunma-ken Azuma-gun Azuma-cho Iwai, Kanagawa-ken Odawara-shi tells that the followers had a sword at the time of the eastward expedition of Yamato Takeru which will be the Yayoi era from the Imperial.
※ Niigata-ken Nagaoka-shi in Fukasawa-cho Kanagawa-ken Kamakura-shi Snow It is Komakura Shogunate's authority of the Kamakura Shogunate who was the authority of Sakunaga and Komachi in the mounds when traveling around the countries in 1258 (Masaka 2 years) Tell them that the residents who were absent and had no surname gave it. From tradition to mound there was the name "surname mound".


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Prodigal Butch
This is the story of how I was recruited into the gender critical movement, what key players I worked with, and how I left.
NOTE: Since this is a public interest story, and I own the rights to all messages that appear, I've blacked out names from the actual images so I can use them in this article. I'm a whistleblower who's been publicly accused of lying and madness by powerful gender critical women, and I have the right to present my evidence. This story has been altered to comply with Medium's rules, but the original version is archived and available online for journalists and the public.
Pride 2018 was a significant recruitment month for the GC movement, but most of us weren't calling it that back then. It was marketed as "lesbian rights" to LGBT people. Theoretically, GCs are critical of gender and question how trans rights impact women's rights, but the reality is no one has brought anything to the table that isn't based in bigotry.
They used fear mongering and misrepresentations to manipulate us into believing lesbians were under attack, that our own greater community was silencing and erasing us. There was nonstop criticism of the left, postmodern queer culture, and LGBTQ+ publications and organizations.
We were constantly triggered. Now I realize we were used as pawns in a culture war. It was never about defending and strengthening lesbians. The goal was to divide our community.
I reviewed approximately thirty thousand screenshots I took during my time in the GC movement, and it was an emotionally difficult task. Today I see the propaganda for what it is, but back then my living situation was unstable. I had to auto camp (sleep in my vehicle) to make ends meet, and I'd recently had a window broken while I was showering at the gym. Meals were inconsistent and I was usually tired, so I was vulnerable to GC fear mongering propaganda.
Compartmentalization was necessary for survival. So were distractions. I worked a full-time job while looking for better work. Except for when I set up camp to sleep, I could forget about my situation and blend in with housed people.
The GC movement made me feel needed. I could put aside my struggles and transcend my hardships by answering what I thought was an ethical call to help lesbians.
There's a kernel of truth to GC propaganda about lesbian erasure, though it's been greatly exaggerated. It's a fact some lesbians have been called "TERFs" (trans-exclusionary radical feminists) or transphobic on social media, simply for being gay. It happened to me on Tumblr, and that's how I was radicalized.
Imagine surviving an evangelical upbringing that told you being gay was a choice, a "bad" choice. Then picture your friends going through conversion therapy that attempted to retrain what genitals they like. Think about spending years of your young adult life when gay sex was illegal, your governor made fear mongering statements about needing to defend his citizens from gay people, and you couldn't even see a gay film at the theater without people shouting at the screen to remind you being gay was "wrong." Try hard to visualize people publicly debating whether you're worthy of raising children and saying maybe you're good enough to have a dog.
Now imagine seeing modern gay media and some blue ticks on Twitter saying lesbians are hateful for not liking penises. I still believe that's homophobic. There's nothing wrong with being same-sex or same-gender attracted. Both are valid and gay. I want acceptance for all of us. It's still illegal to be gay in some countries, and lesbians are correctively raped for not wanting penises. We can't pretend lesbian oppression isn't real.
The reason I and other LGBTQ+ people ever supported GCs and groups like the LGB Alliance was because we were told it's not OK to be gay, as well as how to be gay. Now I realize it wasn't an epidemic, though it was happening on some level. Instead of trying to work with community leaders and media to reach a positive solution for everyone, I assumed the worst and betrayed my values by behaving in some anti-trans ways.
The truth is I had no problem with the concept of trans lesbians before I started hanging around GCs. In fact, I first noticed I'm sometimes attracted to trans women as early as 2003, when I saw one during Gay Days at Disney's Magic Kingdom. She was the inspiration for a fictional character I wrote a few years later. There weren't that many trans women around until recently, but I had a date with one in 2015. I told myself and others it was something else. Now I'm being honest.
Life is complicated and "gay" has evolved to mean same-sex and same-gender attraction. I'll expand on that more in future writing, but the bottom line is if you're secure with your sexuality then you don't feel the need to police others. I was insecure about some things. I was in pain so I hurt others. That was wrong.
Gender critics find what makes you angry and then get you onboard with more of their ideas. I'm explaining how that can happen. Hopefully people listen so we can end this cycle.
This is an overview of the key players and organizations I collaborated with in 2018 and 2019.
Radical feminists and AfterEllen had already influenced me on Tumblr in 2017 with posts and articles that made me think lesbians were under attack. Now I know that was most likely due to Jocelyn Macdonald's influence as assistant editor. She's a radical feminist who supports WoLF (Women's Liberation Front), an organization that claims to be feminist but works with far right groups who are against women's and LGBT rights. WoLF called Macdonald a "trusted friend."
To be clear, Macdonald was not my recruiter. We were connected on Facebook and she supported my punk protest song in 2019, but we no longer talk. My original recruiter won't be named in this article because she's threatened to harm me if I identify her or show her avatar. She has global influence and has been mocking my story, daring me to publish. JK Rowling recently supported her work, which was disturbing. I wanted to tell this story, so I chose to censor her name and image.
When my AfterEllen recruiter connected with me on Twitter in 2018, I was open to her ideas. She love bombed me and constantly sent me upsetting social media posts to keep me triggered. She roped several women into a media war and encouraged us to antagonize LGBTQ+ publications, organizations, and public figures. Coordinated targets included Diva, PinkNews, Autostraddle, Juno Dawson, Grace Petrie, Ruth Hunt, Ellen Page, Chase Strangio, Rhea Butcher, and so many more.
It's notable that AfterEllen's editor-in-chief Memoree Joelle recently stepped down after PinkNews published a story about my GC experience. Joelle also came out in support of Donald Trump. She was replaced by Macdonald, and there were other changes. My first story about lesbian erasure was removed from AE's site this month, but it's still archived.
The publication received criticism in 2018 and 2019 for posting transphobic content. They published radfem and GC influencers Julia Beck, Miranda Yardley, and Ani O'Brien. Joelle co-owns AfterEllen with Gaye Chapman, AKA "GC Grandma."
I wrote a few articles for AfterEllen, but my time there ended in March 2019, when Joelle and I had a falling out.
WoLF (Women's Liberation Front)
WoLF followed me on Twitter and promoted my work on social media. I never officially joined the organization, but I worked with some of its members. I thought about suing Twitter over discriminating against women's free speech, and WoLF member Natasha Chart took notice.
Though I considered working with Republicans, I didn't go through with Natasha Chart's suggestion. Now I know they're religious right people, not regular conservatives. WoLF, Chart, and Emily Zinos had been following me and supporting my work. Chart and Zinos were also in Hands Across the Aisle. Various people suggested I join the organization, but I was dating one of WoLF's founding members, Terri Strange. The best advice she ever gave me was to avoid them.
I don't like to show private messages, but since women involved with my story have chosen to openly mock me instead of coming out to support me, I'm forced to prove this collaboration happened. I'm showing DMs that illustrate organization and influence. My intention isn't to humiliate anyone.
Julia Beck and I became friends. We considered forming a lesbian liberation party and running for president and vice president together. She wanted to join my band, and we would often sing to each other over the phone to work on my music. Sometimes we flirted a little, but that ended after she got a girlfriend on her London visit. She went there in May 2019 to panel at Lesbians on Chairs, which was hosted by Posie Parker. I didn't approve of the event because it was an attack on almost everything I loved about lesbian culture. They promoted the harmful idea that women can "choose" to be lesbians and strategically deny men sex. That panel was a huge red flag.
I tried to make our friendship work, in spite of her political lesbianism and WoLF. Julia was on the verge of telling me she'd been used by the movement. She'd lost a lot of friendships and was receiving weird looks around Baltimore. But Beck was so far deep into WoLF and everything Posie Parker was doing. She wasn't ready to leave them. I really hope she does one day soon. The movement can create an emotional dependency while also alienating its members from the world.
Hands Across the Aisle
An American religious right group called HATA (Hands Across the Aisle) started to reach out to me in 2018. They used points about lesbian erasure that would appeal to me. When I shared my famous TERF article with them, they already knew about it. They asked me to get in touch with Emily Zinos and Natasha Chart, who were already following me.
I didn't understand who HATA was at the time, but by the end of the year I ended up joining their secret Facebook group with Posie Parker. In order to join that group, I had to pretend that I could tolerate their co-founder, Kaeley Triller Harms, who I already knew was homophobic from things she posted.
Julia Beck, Meghan Murphy, and Julia Long also worked with HATA, WoLF, and Standing For Women in the US, UK, and Canada to harm LGBTQ+ rights. They justify working with the US religious right to achieve their goals.
Obviously, there's overlap with international women supporting the same groups. There's a lot more content I don't have room to fit, but what I've shown has connected the dots. I'm collaborating with journalists to further expose this movement in future work.
International Power Lesbians
Anyone who knows anything about lesbian culture understands that a power lesbian is a lesbian influencer. My AfterEllen recruiter organized an international group of lesbian leaders. Some projects happened as a result, though there were just as many plans that never materialized. This group of power lesbians kept expanding over time, and at various points it included my recruiter, writer Claire Heuchan, AE co-owner Gaye Chapman, New Zealand activist Charlie "Montague," ex-WoLF founding member Terri Strange, AE co-owner Memoree Joelle, Speak Up For Women NZ organizer Ani O'Brien, WoLF and HATA member Julia Beck, Get the L Out UK members, and more. We also had one bisexual, who I'll refer to as Homoarchy.
My recruiter wanted me to join Charlie and Claire as the face of this lesbian activism. I was being groomed for it, and she wanted to use the fact that Jared Leto is my cousin to get us noticed. She also exploited my connection to him for the first AfterEllen article I wrote.
Claire, Charlie, and I were going to do a campaign and go on TV for interviews. That didn't happen because the GC movement ended up taking over lesbian activism.
Memoree and Gaye, who now co-own AfterEllen, first met and discussed buying the publication together in our group chat. Ani and Charlie were working on Speak Up For Women, a New Zealand organization that made an impact. As you can see, our group was influential. It evolved into other groups over time.
I have to clarify something in the recent PinkNews article. I never met up with my original recruiter. I did meet up with other women in our international lesbian group, though. After I told Homoarchy about a man who harassed me at a park and ride one night, she offered to rent me a family member's cottage for about three months maximum. I also dated Terri for five months and visited her in Portland.
My critics have made jokes about this power lesbian network, even though some of them were in it. Get the L Out UK has particularly been hypocritical over this since I was in one of their own worldwide organizational chats. It's been disappointing to see so many feminists harass me for speaking truth to power.
Rosa Freedman & Julie Bindel
Most GC influencers were angry at me in fall 2019. I thought the movement would never be reformed because they were unwilling to resolve their major problems, like working with the US religious right and ramping up homophobia and transphobia. A lot of LGBTQ+ people like me were distancing ourselves from the movement and making a new path. Just as I thought I would totally move on, Rosa Freedman reached out.
"I'm just so ashamed of what GC has become," Rosa wrote. She respected that I wanted accountability and ethics in the movement. I also wanted to build bridges with trans activists and LGBTQ+ media and organizations.
We talked about how Linda Bellos and Julia Beck were being used by WoLF. Then Rosa connected me to Julie Bindel.
Bindel promised me the world on our first phone call, and I wrote to Rosa about what we discussed. They both wanted to help me get settled down in the UK. Rosa said there were a lot of Scottish women interested in me. Julie said she would have to give approval for all my wife candidates. I saw it as an incentive to move over and work with them. What lesbian wouldn't be thrilled at the idea of having so many women into her?
Some people confused the wife detail in the PinkNews story for human trafficking and wild takes like that. What was actually proposed was more in the spirit of Butch Bachelor: GC Edition hosted by Julie Bindel. I was into it at the time.
Bindel said we would co-write some articles together, co-panel talks, and make unified statements on social media to influence the direction of the movement. I was going to stay in Julie's home, and we were looking forward to visiting Kensington Gardens so I could meet and take a walk with one of my favorite celebrity corgis. Miranda Yardley wanted to join us for a night out. The LGB Alliance was following me on Twitter, and they wanted to meet with me during my trip. A lot of people wanted to see me. Everything was moving fast, and Julie Bindel seemed to be my new best friend.
Rosa was going to fly me out and put me up in a hotel wherever there weren't women to host. Julie and I would talk about the differences between American law and UK law at Rosa's university. She was negotiating with Woman's Place UK to frame an event around me in England. She also was talking to For Women Scot, the late Magdalen Berns' organization, about having me do a talk with Claire Heuchan in Edinburgh.
"You're a major player in the rad fem sisterhood," Rosa wrote. She said I could speak about whatever I wanted. It was all exciting.
On November 4, 2019, I told her I'd settled on dates for my trip. I wanted to visit the inside of Anne Lister's Shibden Hall, and I was going by the site's schedule. Rosa said feminists were planning a big conference for early February, which was a little earlier than I'd planned, but I considered it.
Then Judith Green, a Woman's Place UK founder who'd been following me on Twitter for awhile, attacked me for criticizing political lesbianism. I was also pointing out that some Get the L Out UK members love Posie Parker. They've sent me messages pledging their allegiance to PP. Green tried to create a radfem pile-on by tagging in influential GC women, like Kathleen Stock, to argue with me.
As a lesbian, I no longer felt safe or valued at Woman's Place UK events. It felt like a hostile community. I told Rosa about what happened, and I said I still wanted to come over but I didn't want to do anything with WPUK. I also postponed the trip for a warmer time. A lot's happened since then, including a global pandemic.
Recently, Julie Bindel called me delusional, attacked my integrity and mental health, and gaslit me. She tried to claim we were never connected and that none of what I've written in this article is true. My receipts, which I have the right to show since she's publicly challenged me, prove Bindel is lying and being abusive toward me.
There's a lot more I could reveal about Julie Bindel, but I've already proven the points I want to make about her in this article. I will state it's interesting that such a powerful woman as herself would use her platform to attack a lesbian whistleblower instead of condemn the sexual harassment and abuse that people in her movement have thrown at me and other lesbians lately.
After trying to navigate a GC world that said "f*ck kind," I longed for kindness. I didn't think I was anti-trans, but looking back over the screenshots it's clear that I was. The whole time, I had LGBTQ+ friends around the world telling me they didn't like the GC stuff. However, what's alarming is some friends did listen. I radicalized some people and regret it. Hopefully they'll listen to me now and find their way out of gender critical culture.
In 2019, gender critics ramped up personal attacks on trans people, and they also focused on hating Pride, the rainbow, and gay and lesbian culture. It hurt to see it back then, and they've only gotten worse. Do GCs know what their endgame is anymore? Did they ever?
WoLF, Posie Parker, Meghan Murphy, the LGB Alliance, and others derailed any possible legitimate concerns GCs and radical feminists had about the trans rights movement. The culture is unapologetically anti-left and has chosen to die on that hill.
The rise of "political lesbianism," an anti-lesbian ideology, also made me leave the movement. Sheila Jeffreys, Julie Bindel, and Angela Wild are political lesbians who harm international lesbian rights by stating lesbianism is a "choice." Lesbian rights depend on "born this way," and they selfishly don't care. GC influencers only value PLs. Anyone who claims being gay is a choice shows their privilege, as well as their lack of understanding of gay rights.
One of the main things that helped me leave the GC movement was seeing my trans friends from real life posting about their hopes, community needs, and fears. It made me feel conflicted throughout my time with gender critics. In fall 2019, I was upset after seeing a friend describe workplace discrimination and how hard it was to find a restroom to use. I didn't want anyone to feel that way, so her words solidified my need to get off the GC path.
On February 1, 2020, I was at the Seattle protest against WoLF and Meghan Murphy instead of being protested at Woman's Place UK across the pond. I spoke to a lot of trans activists and enjoyed having physical LGBTQ+ community again, even though it was so cold that my nose sometimes ran. There was a lot of anti-TERF sentiment with signs and chants, but I wasn't triggered. I understood the anger.
I made videos about that protest and uploaded other videos a trans activist sent me. Some people in the LBGTQ+ community are still upset with me, and I have specific apologies to give a few. Most people have been forgiving and want to understand more of how I got into the GC world. Like I've said before, it would take a book to fully tell my story. There's a lot I didn't have room to include, but I hope this article clarifies some details and fills in some blanks.
This year I've been challenging myself. I've been talking to a lot of people in the trans community. There are some topics I won't talk about yet since I haven't had time to properly research them, but I've been learning a lot. I want to continue working with my community to accomplish the most good. If any gender critics are reading this, I hope you pay attention to the red flags you've been seeing and find your way out. It's OK to talk about concerns with empathy. If you have a friend trying to help you get out, take that hand because that's love. We can stop our real opponents together.
If you're interested in lesbian news and culture, you can find me on Twitter as Amy Dyess.


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Five Nylon Gym Sack
Five's nylon gym sack has a large prominent logo to front with a minimal lightweight design and drawcord closure. This gym sack is the perfect accompaniment for going to the gym and daily use.
> Large five branding to the front
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Product code: 700520


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Packet radio is a form of packet-switching technology used to transmit digital data via radio or wireless communications links. It uses the same concepts of data transmission via datagram that are fundamental to communications via the Internet, as opposed to the older techniques used by dedicated or switched circuits.
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Gerard Pique agrees three-year contract extension with Barcelona after attending Billboard Music Awards with Shakira in Las Vegas
- Contract will keep Pique at the Nou Camp until 2019
- Financial terms of the deal not released by Barcelona
- Pique was in Las Vegas with Shakira at Billboard Music Awards on Sunday
Barcelona defender Gerard Pique has agreed a three-year contract extension that ties him to the club until 2019.
The Spain international has been an integral part of Barcelona's success, helping the club win two Champions Leagues titles and five of the past six league trophies since his arrival in 2008.
Barcelona did not release financial terms of the deal, which the club says will be signed 'in the next 10 days.'
VIDEO Scroll down to watch Shakira's raunchy performance at the Billboard Awards 2014
Jumping for joy: Gerard Pique has signed a three-year contract extension with Barcelona
Red carpet: The Spanish defender joined Shakira at the Billboard Music Awards in Las Vegas
Road to Rio: Pique will join up with the Spanish national squad ahead of the World Cup in Brazil
The former Manchester United defender was in Las Vegas with partner Shakira at the Billboard Music Awards on Sunday.
He will link-up with the Spain squad shortly as they look to defend their World Cup in Brazil this year.
Pique has made 266 appearances for Barcelona, scoring 20 goals, and will most likely partner Sergio Ramos in the centre of defence for Spain in Brazil.
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Wien, Autriche
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"Schloss Schoenbrunn" this is our back garden, Anywhere that is anywhere in Vienna within 15-20 min, (Public-Bike). Vienna main attractions at your door step. Christmas markets, Coffee Houses, Schnitzel restaurants, Naschmarkt MuseumQuartier. Our 100sqm apartment is located on complete 1st floor with balcony and Terrace. Bedrooms, Bathroom, Kitchen and all living arias a presently light filled. We are very house proud and like to keep everything well maintained. (Cleaner included). We think our place would be an idea base to recharge and get out amongst it! "Sound of Music" tour in Salzburg, Skiing in Tirol, Mountains everywhere. Central Europe your options are almost endless, Italy, Croatia, Czech, Hungary, Germany, France, Uk
We are an International Family Australian & Austria
Enjoy working Holidays to get Family back home
Bibi 37 Airline staff, Justin 43 Industrial climber and Zoe 4, Jake & Luis our new twins boys
Our home is located in 22nd District of Vienna. It is few minutes walk from subway station, which takes you directly to the city center in 15 minutes. The...
** OUR HOME IS AVAILABLE 15th to 20th December - The week before Christmas in VIENNA! Note: 4 nights min ** 160m2 big space in the city center at a little...
more pictures coming soon! Spending April in LA - hoping to swap:) Beautiful, bright, 175 square meters (about 1800sqft) apartment in a 19th century "Altbau"...


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ELIZABETH – Once again, dockfront Legislative District 20 marks the scene of arguably the most compelling election of the season, as one of the state's last surviving pit bosses of his generation, veteran Senator Ray Lesniak, faces a single mother from Roselle with little to no political experience.
On Wednesday afternoon, Donna Obe, president of the Roselle Board of Education, mounted the steps of a bus decked in red, white and blue across from the downtown realty office of Rafael Fajardo, Lesniak's longtime political nemesis, and rival local overlord in charge of the Elizabeth Board of Education.
"The reality is that people are numb," she said. "When I campaign, people all the time tell me, 'why didn't I get involved earlier?' It is time for this to stop."
Her smile radiated a political neophyte vibe, and PolitickerNJ.com asked her how voters could square that image with the relentless barrage of negative mail Fajardo's forces have laid down on her behalf against the incumbent power broker.
"It's not negative," said Fajardo, appearing from around the corner of the bus.
"It's the truth," insisted the former president of the Elizabeth Board of Education. "He has made money on the backs of the people of this district. That's what we're putting out there. That hurts him? What about the pain he has caused people who have to decide between paying their taxes and paying for their medicine while he cuts deals with developers?"
PolitickerNJ.com got Lesniak on the telephone.
"My opponent is running a negative and slanderous campaign, while I have run a positive race based on my record," the senator said.
"It's obvious Fajardo's running the campaign, and he's making a mess of it," he added.
The latest issue of "The County Post," a newspaper from the workshop of the Fajardo inner sanctum that backs Obe mostly by bashing Lesniak, features a two-page itemization of all the senator's corporate donors – $576,000 and counting – and the question, "Here it is in black and white how Senator Lesniak sold us out."
Two Fajardo operatives made their way to headquarters with the latest round of glossy mailers from the opposition.
The first shows a picture of U.S. Sen. Bob Menendez (D-NJ) and a ringing endorsement. "From pathway to citizenship to the Dream Act, Raymond Lesniak has been the leading voice for us in Trenton," Menendez says. "No one fights harder on these issues."
The second piece features Elizabeth Mayor Chris Bollwage, who destroyed his challenger last year and whom Lesniak enlisted for his latest television ad.
"Vote Column B," the mailer declares. "Mayor Bollwage's Elizabeth Hometown Team."
A larger-sized photo of Bollwage anchors a train of smaller photos of the candidates, including Lesniak, Assemblywoman Annette Quijano (D-20), Freeholder Sergio Granados, and Democratic State Committeewoman Patricia Perkins-Auguste.
Notably absent from the piece paid for by the Election Fund of Bollwage is Assemblyman Joe Cryan (D-20), who like his running mate Quijano, lacks a primary opponent, a political decision made by Fajardo and company in the waning hours before ELEC's filing deadline. Lesniak's allies say the piece is Elizabeth-focused only, which explains Cryan's absence.
But regardless, Cryan is not ubiquitous the way he was last time.
The assemblyman drove a 3-1 plurality out of his hometown of Union Township two years ago to blunt the impact of then-Lesniak challenger Jerome Dunn defeating Lesniak in Elizabeth by 500 votes. By refusing to engage Cryan, and by refusing to engage the incumbent ticket's lone Latina (Quijano) and focusing all their firepower on Lesniak, Obe's allies hope to lull the game Irish American pol – chairman of the Union Township Democratic Party – to sleep and diminish Lesniak's local Latino base.
There are four towns in the 20th district: the half African-American, half white Hillside (6,212 registered Democrats), mostly African American Roselle (7,030 registered Democrats), a white Catholic stronghold in Union (12,086), and the Hispanic-dominant Elizabeth (25,222 registered Democrats), which Lesniak has represented for over 30 years.
Obe lives in Roselle, where Lesniak is counting on low name ID by the challenger and proven winner Roselle Mayor Jamel Holley getting out the vote to check former Mayor Garrett Smith looking for payback in the form of his alliance with Obe.
In Hillside, Fajardo has strong ties to incumbent Mayor Joe Menza, who's up for re-election this year, but running as an independent in the November general election. Having announced her decision to retire as Union County Democratic Committee Chair, Lesniak ally Charlotte DeFilippo does not project strength at the moment from her local political perch.
Fajardo's team trusts a sidelined Cryan will preside over less than invasion-like numbers in Union, which leaves Elizabeth.
"It comes down to Elizabeth," said Fajardo, smoldering as he held in his hands a glossy mailer put out by Lesniak's allies during the school board election earlier this year, which showed the backs of pigs at a long trough.
Inside, the mail piece noted the presence of Fajardo family members on the public dime.
"He hurts over what we're throwing at him?" he wanted to know. "Tell me, is anything we put out as bad as this?"
While staying positive in his own campaign mail, Lesniak has harped throughout behind the scenes on Obe's ties to the Elizabeth Board of Education.
The incumbent gave a savage beating to the Board of Education over then-Board President Marie Munn's allegedly illegal participation of her children in the school lunch program.
Hurtful headlines hounded the Board of Education since last year, one of the reasons the inner sanctum selected the unknown Obe to run against Lesniak rather than Fajardo or sitting Board President Tony Monteiro.
"Explosive newspaper stories," he said, confident that he has immobilized the rival local outfit, rejoicing last month as the state AG's Office rounded up the Board of Education's attorneys and another former board member, three more Fajardo allies.
The question at Fajardo HQ is whether those arrests scared others into no longer wanting to participate, or quietly motivated them to take revenge.
A man with dark shades appeared in Downtown Elizabeth.
He described himself as a Fajardo ally.
""Fear," he said. "We have to deal with the issue of fear out there among some of our people."
Based on their performance last time, Fajardo said he believes they can turn out winning numbers for Obe, particularly since Lesniak hired two operatives who ran Oscar Ocasio's doomed race last year to head up the senator's 2013 field operation in Elizabeth.
The operatives and some members of Fajardo's team did not leave on good terms.
"We have every confidence that they are working very well for us," said Fajardo, referring to Lesniak's team, and unable to resist cracking a smile.


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Current Auction ends from 7pm GMT on Monday 7 December. Deadline for Extended December Auction is Monday 14th December. Click here for our COVID-19 Information Page
Karuizawa Spirit of Asama Collection 3 x 70cl
Two Whisky Exchange exclusive Karuizawas bottled by Number One Drinks. Vatted from 77 casks distilled between 1999 and 2000 at the Japanese disillery. Comes in two strengths, 48% and 55%.
Also an exclusive Swedish release of Karuizawa Asama bottled at 46%, rare and rarely seen at auction. Named after the active volcano located near the now closed distillery, this single malt is comprised of 1999 and 2000 vintages which were some of the last the distillery produced. The whisky has been matured in European oak sherry and bottled in 2012.
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Home decorative screens Decorative Screen Balustrade Decorative Timber Balustrade Bunnings Panels Nz Screen In The Hearth For Protection
There are a number of different kinds of screens based on their usage. The screens are offered in a selection of styles that range from antique, traditional, to contemporary styles. Folding screens are available in many places. You're able to still become antique folding screens, but they are extremely costly. Today there are a lot of interesting decorative fire screens which are both functional and decorative.
If you don't want something very heavy, then you may go for folding screens made from softwood. Soundproof screen is appropriate for new and present structures, without the demand for floor track. A decorative panel screen is regarded as a sculptural piece. When you have the panels picked out you can begin to apply the decorative touches you desire.
There are many kinds of materials you may utilize to create the folds. Lightweight material is essential to avoid sagging in the middle of the line. By making use of a rope line, you will be able to push back the material divider when you wish to open up the space, and you may get rid of the divider just as rapidly.
If you're looking for a way to alter the expression of your house in the most cost-effective way, the partition can be the perfect option for you. With numerous various styles and sizes to select from you can make a decision as to what look and degree of privacy you demand. Or, if you would like a more modern appearance, select the morse pattern.
Regardless of what design, style or use you may try to find in room dividers, there's an endless quantity of dividers to select from. A room divider is able to help you create a private little hide away where you are able to read, listen to music or simply have some alone time. Nobody will even know that you're employing the room divider to hide clutter. Room dividers are available in many sizes based on the range of panels. Expensive and original or affordable and conventional room dividers offer you attractive designs for each and every budget and taste.
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The goal of this work was to characterize the profile of bioactive compounds and the antioxidant activity of inodorus melon peels. Melon peels were divided into three fractions: a solid fraction with a higher content of carbohydrates (84.81%); a liquid fraction with a higher ash content (11.5%); and a pellet fraction with a higher protein content (34.90%). The structural carbohydrates study revealed a composition of cellulose (27.68%), hemicellulose (8.2%) and lignin (26.46%) in the solid fraction. The liquid fraction had the highest antioxidant activity based on results from DPPH, ABTS and ORAC assays. Flavones, hydroxybenzoic and hydroxycinnamic acids were the main phenolic classes found in all fractions. In addition, ß-carotene, lutein, ß-cryptoxanthin and violaxanthin had also been quantified. Melon fractions were rich in nutrients and bioactive substances and could be useful in the development of novel functional products, considering the growing market demand for safe and healthy food products.
AssuntosAntioxidantes/farmacologia , Cucurbitaceae/química , Ingredientes de Alimentos , Alimento Funcional , Fibras na Dieta/farmacologia
Microgreen based functional juice blends containing fenugreek (Trigonella foenum-graecum), kinnow mandarin (Citrus reticulate) and aloe vera (Aloe brobadensis) in different ratios were blended with sorbitol and stevia. The different ratios of juice blends were analyzed for total soluble solids, sedimentation, viscosity and titrable acidity. They were also screened for total phenolic content, total carotenoid content and antioxidant properties such as DPPH, reducing power and metal chelating activity. The formulation with highest TPC, TCC and antioxidant property was selected to optimize a microgreen based functional juice. The optimized microgreen blend formulation had 20 ml 100-1 ml microgreen juice, 40 ml 100-1 ml kinnow juice, 8.5 ml 100-1 ml sorbitol, 1.78 g 100-1 ml stevia and 29.72 ml 100-1 ml aloe vera juice. It had high protein, minerals (sodium and potassium) and vitamin (vitamin C) content as well as good source beta-carotene, phenols and antioxidants. Antioxidant helps in reducing diabetic complications by reducing the oxidative stress and because of their protective action against reactive oxygen species.
AssuntosAntioxidantes , Frutas , Alimento Funcional , Antioxidantes/análise , Antioxidantes/farmacologia , Ácido Ascórbico/análise , Bebidas/análise , Frutas/química , Fenóis/análise
The bioavailability of DHA-bound phospholipids, especially the DHA-bound lysophospholipid (DHA-LPL) could be considered the most effective DHA chemical forms for DHA accretion in the brain. Such a DHA-LPL should also have very high emulsifying stability performance based on its analogy with conventional soy LPL. Therefore, in this study, we describe two fishery byproducts, rich in DHA-bound phospholipids, to derive DHA-LPL via sn-1 positional specific lipase partial hydrolysis of the phospholipids. Through this reaction, the DHA composition increased to 43.8 % from 29.1 % in the salmon head phospholipid-derived DHA-LPL, and to 84.0 % from 47.4 % in the squid meal phospholipid-derived DHA-LPL. In fact, these obtained DHA-LPLs exhibited far higher emulsifying stability than the conventional food emulsifiers in the market. For example, the prepared high-purity squid meal phospholipid-derived LPL sustained an emulsion form for a week even under 80°C. Thus, food emulsifiers produced from fishery byproducts are considered to exhibit very high values of both in a sense of outstandingly high health benefits and sustaining emulsions even under very high temperatures.
AssuntosÁcidos Docosa-Hexaenoicos/química , Ácidos Docosa-Hexaenoicos/isolamento & purificação , Emulsificantes/química , Emulsificantes/isolamento & purificação , Produtos Pesqueiros/análise , Alimento Funcional , Lisofosfolipídeos/química , Lisofosfolipídeos/isolamento & purificação , Estabilidade de Medicamentos , Temperatura Alta , Hidrólise , Lipase/química
BACKGROUND: Few studies have evaluated iron-rich plant-based foods, such as amaranth grain, to reduce anemia and iron deficiency anemia. Amaranth is rich in nutrients, but with high level of phytate. The objective of this trial was to evaluate the efficacy of home processed amaranth grain containing bread in the treatment of anemia, hemoglobin concentration and iron deficiency anemia among two-to-five year-old children in Southern Ethiopia. METHOD: Children with anemia (hemoglobin concentration <110.0g/L) (N = 100) were identified by random sampling and enrolled in a 1:1 cluster randomized controlled trial for six months in 2017. The amaranth group (N = 50), received 150g bread containing 70% amaranth and 30% chickpea, the amaranth grain was processed at home (soaking, germinating, and fermenting) to decrease the phytate level. The maize group (N = 50), received 150g bread, containing processed maize (roasted and fermented) to give a similar color and structure with amaranth bread. Hemoglobin, ferritin, and CRP were measured at baseline and at the end of intervention. Hemoglobin and ferritin values were adjusted for altitude and infection, respectively. Generalized estimating equation and generalized linear model were used to analyze the data. RESULT: In the last follow-up measure anemia prevalence was significantly lower in the amaranth group (32%) as compared with the maize group (56%) [adjusted risk ratios, aRR: 0.39 (95%CI: 0.16-0.77)]. Hemoglobin concentration estimate of beta coefficient was significantly higher in the amaranth group compared with the maize group [aß 8.9g/L (95%CI: 3.5-14.3)], p-value <0.01. The risk of iron deficiency anemia is significantly lower in the amaranth group [aRR: 0.44 (95%CI: 0.23-0.83)] in the intention to treat analysis but not significant in the complete case analysis. There was no significant difference between groups in iron deficiency [aRR: 0.81 (95%CI: 0.55-1.19)]. CONCLUSION: Processed amaranth bread had favorable effects on hemoglobin concentration and has the potential to minimize anemia prevalence. CLINICAL TRIAL REGISTRATION: Trial registry number: PACTR201705002283263 https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=2283.
AssuntosAmaranthus , Anemia Ferropriva/dietoterapia , Pão , Ferro/metabolismo , Zea mays , Pré-Escolar , Suplementos Nutricionais , Etiópia , Feminino , Ferritinas/sangue , Alimentos Fortificados , Alimento Funcional , Hemoglobinas/análise , Humanos , Ferro/deficiência , Masculino
Accumulating evidence suggests that gut microbiota plays a crucial role in the development of metabolic diseases, especially type 2 diabetes mellitus (T2DM). The nutrient-rich resource Cornus Fructus (CF) showed curative effects on diabetes mellitus. However, the mechanism underlying its hyperglycemic activity remains obscure. Herein, the antidiabetic potential of four extracts from CF, including saponin (CTS), iridoid glycoside (CIG), tannin (CT), and alcohol extract (CCA) was evaluated in vivo. The results showed that all four extracts could increase the body weight, decrease the blood glucose levels, and elevate the glucose tolerance. Moreover, insulin sensitivity and lipid profile were significantly improved in fed mice. In the [Formula: see text]-diversity index of samples, compared to the DM group, the diversity and richness of gut microbiota in mice to a certain extent were reduced in both CF extracts and Metformin (PC). Among them, there was statistical significance in PC (ACE, [Formula: see text]) and CCA (ACE, [Formula: see text]; chao1: [Formula: see text]). Beta diversity showed the same trend as the UPGMA clustering trees, which revealed that CF extracts could improve intestinal homeostasis in T2DM mice. Also, CF extracts could elevate the production of short-chain fatty acids, as well as regulate the composition of gut microbiota. The key bacteria related to T2DM including Firmicutes, Bacteroides, Lactobacillus, and Clostridium were modulated by metformin and CF. Altogether, CF is a potential nutrient-rich candidate that can be used in functional foods for the treatment of T2DM, and the change of gut microbiota might be a novel mechanism underlying its hyperglycemic activity.
AssuntosCornus/química , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/microbiologia , Microbioma Gastrointestinal/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Animais , Glicemia/metabolismo , Peso Corporal/efeitos dos fármacos , Diabetes Mellitus Tipo 2/etiologia , Modelos Animais de Doenças , Alimento Funcional , Resistência à Insulina , Glicosídeos Iridoides , Metabolismo dos Lipídeos/efeitos dos fármacos , Masculino , Camundongos Endogâmicos ICR , Extratos Vegetais/química , Saponinas , Taninos
Novel coronavirus (COVID-19) is causing global mortality and lockdown burdens. A compromised immune system is a known risk factor for all viral influenza infections. Functional foods optimize the immune system capacity to prevent and control pathogenic viral infections, while physical activity augments such protective benefits. Exercise enhances innate and adaptive immune systems through acute, transient, and long-term adaptations to physical activity in a dose-response relationship. Functional foods prevention of non-communicable disease can be translated into protecting against respiratory viral infections and COVID-19. Functional foods and nutraceuticals within popular diets contain immune-boosting nutraceuticals, polyphenols, terpenoids, flavonoids, alkaloids, sterols, pigments, unsaturated fatty-acids, micronutrient vitamins and minerals, including vitamin A, B6, B12, C, D, E, and folate, and trace elements, including zinc, iron, selenium, magnesium, and copper. Foods with antiviral properties include fruits, vegetables, fermented foods and probiotics, olive oil, fish, nuts and seeds, herbs, roots, fungi, amino acids, peptides, and cyclotides. Regular moderate exercise may contribute to reduce viral risk and enhance sleep quality during quarantine, in combination with appropriate dietary habits and functional foods. Lifestyle and appropriate nutrition with functional compounds may offer further antiviral approaches for public health.
AssuntosInfecções por Coronavirus/prevenção & controle , Dieta/métodos , Exercício Físico , Alimento Funcional , Estilo de Vida , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Antivirais/administração & dosagem , Betacoronavirus , Suplementos Nutricionais , Humanos
Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as a health aid and immune system booster. The COVID-19 pandemic has renewed interest in propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for propolis compounds. SARS-CoV-2 entry into host cells is characterized by viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2. This mechanism involves PAK1 overexpression, which is a kinase that mediates coronavirus-induced lung inflammation, fibrosis, and immune system suppression. Propolis components have inhibitory effects on the ACE2, TMPRSS2 and PAK1 signaling pathways; in addition, antiviral activity has been proven in vitro and in vivo. In pre-clinical studies, propolis promoted immunoregulation of pro-inflammatory cytokines, including reduction in IL-6, IL-1 beta and TNF-α. This immunoregulation involves monocytes and macrophages, as well as Jak2/STAT3, NF-kB, and inflammasome pathways, reducing the risk of cytokine storm syndrome, a major mortality factor in advanced COVID-19 disease. Propolis has also shown promise as an aid in the treatment of various of the comorbidities that are particularly dangerous in COVID-19 patients, including respiratory diseases, hypertension, diabetes, and cancer. Standardized propolis products with consistent bioactive properties are now available. Given the current emergency caused by the COVID-19 pandemic and limited therapeutic options, propolis is presented as a promising and relevant therapeutic option that is safe, easy to administrate orally and is readily available as a natural supplement and functional food.
AssuntosAntivirais/farmacologia , Infecções por Coronavirus/tratamento farmacológico , Pneumonia Viral/tratamento farmacológico , Própole/farmacologia , Animais , Antivirais/administração & dosagem , Betacoronavirus/efeitos dos fármacos , Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/complicações , Infecções por Coronavirus/virologia , Suplementos Nutricionais , Alimento Funcional , Humanos , Macrófagos/efeitos dos fármacos , Macrófagos/imunologia , Monócitos/efeitos dos fármacos , Monócitos/imunologia , Pandemias , Pneumonia Viral/complicações , Pneumonia Viral/virologia , Própole/administração & dosagem
El consumo de proteína y especialmente aminoácidos esenciales juega un papel fundamental en la dieta, ya que suple las necesidades de nitrógeno del organismo y favorece el mantenimiento de estructuras corporales. En los últimos años, la nutrición y la tecnología de los alimentos están experimentando una profunda transformación debido al desarrollo del concepto de alimentos funcionales y nutracéuticos. Tanto las proteínas funcionales como los péptidos bioactivos están cobrando gran importancia ya que, además de su papel nutricional por ser fuente de aminoácidos, son capaces de ejercer diferentes efectos biológicos específicos sobre el sistema inmune, el sistema cardiovascular o el tracto gastrointestinal. Los aminoácidos de cadena ramificada (BCAAs denominación por las siglas en inglés) como lo son la Leucina, Isoleucina y Valina son considerados útiles para el tratamiento y predicción de algunas enfermedades, el presente artículo de revisión, se recopila información acerca de los aminoácidos de cadena ramificada y su uso positivo en el tratamiento de diferentes patologías como enfermedades neurológicas, hepáticas, cardiometabólicas, cáncer, además de su uso en deportistas. Se tuvieron en cuenta los siguientes criterios de inclusión: 1. La búsqueda se realizó en reconocidas bases de datos, 2. Se incluyeron artículos desde el 2006 a la fecha, 3. Se realizó la búsqueda con palabras como aminoácidos de cadena ramificada y efecto en diferentes patologías, con la inclusión de artículos donde se menciona el consumo humano de los mismos, se excluyeron artículos donde los aminoácidos no intervengan de manera positiva en su consumo y tratamiento de enfermedades(AU)
The consumption of protein and especially essential amino acids play a fundamental role in the diet, in order to meet the body's nitrogen needs and the maintenance of body structures. In recent years nutrition and food technology are undergoing a profound transformation due to the development of the concept of functional foods and nutraceuticals. Both functional proteins and bioactive peptides are becoming very important since, in addition to their nutritional role as a source of amino acids, they are capable of exerting different specific biological effects on the immune system, the cardiovascular system or the gastrointestinal tract. Branched-chain amino acids (BCAAs), such as Leucine, Isoleucine and Valine, are considered useful for the treatment and prediction of some diseases. This review article collects information about branched-chain amino acids. and it's positive use in the treatment of different pathologies such as neurological, liver, cardiometabolic diseases, cancer, in addition to it's use in athletes. The following inclusion criteria were taken into account: 1. The search was carried out in recognized databases, 2. Articles were included from 2006 to date, 3. The search was carried out with words such as branched-chain amino acids and effect in different pathologies, with the inclusion of articles where their human consumption is mentioned, articles were excluded where amino acids do not intervene positively in their consumption and treatment of diseases(AU)
AssuntosHumanos , Proteínas , Dieta , Composição de Alimentos , Alimento Funcional , Aminoácidos de Cadeia Ramificada , Compostos de Nitrogênio , Tecnologia de Alimentos , Valor Nutritivo
Date fruit is well known for their taste and concentrated nutritional components. Present study investigated two Omani date varieties i.e., Umsellah and Khalas, related to their physical traits, antioxidant properties, carbohydrates and nutritional values. Results showed that total-phenolic in Umsellah were 62% higher compared to Khalas, i.e., 164.22 and 103.85 mg/100 g. Among antioxidants, gallic acid in both Umsellah and Khalas were 35.77 and 27.41 mg/ 100 g respectively. Caffeic and syringic acid resulted 50% greater in Umsellah compared to Khalas. The ρ-coumaric acid contents in Umsellah and Khalas were 24.94 and 21.69 mg/ 100 g respectively. Total sugar in Umsellah (51.37 g of glucose equivalent / 100 g of dates) was found higher compared to Khalas (44.78 g of glucose equivalent / 100 g of dates). Among nutrients, potassium (K) level is very high (> 450 mg/100 g) in both the varieties with optimum range of other nutrients. For dietary fibers, Umsellah (81.17 g/100 g) reported higher proportion than Khalas (67.35 g/100 g). Overall findings inferred that Umsellah contained greater amount of beneficial individual phenolic and sugar compounds for the nourishment of health than Khalas. Therefore, as high antioxidant and nourished with several nutritional components, Umsellah and Khalas can be well adopted as organic and medicinal diets and can be used for various by-products irrespective of their market value.
AssuntosPhoeniceae , Antioxidantes , Dieta Saudável , Frutas , Alimento Funcional
The repositioning of therapeutic agents already approved by the regulatory agencies for the use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of using molecules derived from foods, whether nutrients or not, is of great importance, also because of their immediate therapeutic applicability. Candidates for these natural therapies against COVID-19 should show certain effects, such as restoring mitochondrial function and cellular redox balance. This would allow reducing the susceptibility of risk groups and the cascade of events after SARS-CoV-2 infection, responsible for the clinical picture, triggered by the imbalance towards oxidation, inflammation, and cytokine storm. Possible strategies to follow through the use of substances of food origin would include: a) the promotion of mitophagy to remove dysfunctional mitochondria originating from free radicals, proton imbalance and virus evasion of the immune system; b) the administration of transition metals whose redox activity would lead to their own oxidation and the consequent generation of a reduced environment, which would normalize the oxidative state and the intracellular pH; c) the administration of molecules with demonstrated antioxidant capacity; d) the administration of compounds with anti-inflammatory and vasodilatory activity; e) the administration of immunomodulatory compounds.
AssuntosBetacoronavirus , Infecções por Coronavirus , Alimento Funcional , Nutrientes , Pandemias , Pneumonia Viral , Antioxidantes/uso terapêutico , Humanos , Mitocôndrias/metabolismo , Nutrientes/uso terapêutico
By-products of Belgian endive represent an interesting yet underutilised source of dietary fibre (DF). Dietary fibre concentrates (DFC) that are low in sugar and neutral in taste are sought by the food industry to increase DF content and improve texture in food products. The aim was to set up a biorefinery process to produce DFC from forced roots of Belgian endive (DFC-BE) and characterise the resulting product. As a control, non-treated forced roots powder (FRP-BE) was tested. Water extraction significantly (p < 0.05) decreased the content of sugars, phenolic acids (PA) and sesquiterpene lactones (SL) in DFC-BE. In contrast, total dietary fibre concentration (TDF) was higher in DFC-BE (81.82 g/100 g DW) in comparison to FRP-BE (49.04 g/100 g DW). DFC-BE offers an excellent water holding capacity (WHC) of 14.71 g water/g DW and a swelling capacity (SWC) of 23.46 mL water/g DW, suggesting possible use as a functional food ingredient.
AssuntosChicória/química , Fibras na Dieta/análise , Extratos Vegetais/química , Resíduos/análise , Bélgica , Alimento Funcional/análise , Raízes de Plantas/química , Pós/química , Verduras/química
The physicochemical and physiological properties of soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) from bamboo shoots were investigated in present study. IDF showed better adsorption capacity than the corresponding SDF from the same species. Microstructure observation results indicated that the surface of IDF was porous, whereas the SDF was relatively flat and compact. The cholesterol-adsorption capacities of IDF and SDF from Fargesia spathacea were relatively higher than the other species. Both SDF and IDF from F. spathacea showed potential prebiotic effects, although the Lactobacillus and Bifidobacterium promotion effects of SDF were relatively stronger than IDF. Compared with control, the concentration of total short chain fatty acids in IDF and SDF supplement groups were increased by 1.28 and 0.71 folds, respectively. These results suggested that F. spathacea dietary fibers with strong cholesterol-adsorption activity and prebiotic potential, could be used as a bioactive ingredient in functional foods production.
AssuntosAnticolesterolemiantes/química , Anticolesterolemiantes/farmacologia , Fibras na Dieta/farmacologia , Caules de Planta/química , Poaceae/química , Prebióticos , Fenômenos Químicos , Suplementos Nutricionais , Alimento Funcional/análise
Traditional Chinese medicine(TCM) is the treasure of our culture, and TCM theory is the core of traditional Chinese medicine. Many of its concepts can be unified and balanced with modern functional food ideas. Even in ancient days, people had already found that medicine and food have the same source. Nowadays, homology between drug and food has been accepted widely. Astragali Radix and some other herbs have been used both as food and medicine, with a variety of bio-active substances, so such herbs can be used as characteristics resources to be developed into functional food. It's a combination of traditional medicine and modern ideas. Flavonoids, polysaccharides and saponins, the main compositions of Astragali Radix, can keep intestinal microenvironment homeostasis and human health by influencing the population structure, metabolism and intestinal cell function of intestinal flora. On the other hand, intestinal flora is also involved in the absorption, metabolism, transformation and other steps of these active ingredients in the body, which has an impact on their effectiveness and improves their bioavailability, playing an essential role in the relevant mechanism of their effectiveness. In this paper, we summarize the interaction between the above three functional ingredients in Astragali Radix and intestinal flora, sum up the interaction between these three functional ingredients of other homologous drugs and intestinal flora, provide a theoretical basis for the mechanism and application of functional food materials, and propose some suggestions and prospects for their future development.
AssuntosAstrágalo (Planta) , Medicamentos de Ervas Chinesas , Microbioma Gastrointestinal , Alimento Funcional , Humanos , Medicina Tradicional Chinesa
Functional food material, polyamines are considered to be essential for growth factors in virtually all cells. The polyamines putrescine, spermidine and spermine are low molecular weight organic polycations, well known as mediators involved in cell homeostasis. The proposed functions of polyamines are the regulation of ion channels, nucleic acid packaging, signal transduction, cell proliferation, and differentiation, as well as gene expression. In skeletal muscle, regulation of polyamine levels is associated with muscle hypertrophy and atrophy, yet detailed studies are remained to be undergoing. Here, we studied how polyamines may affect the proliferation and/or differentiation of murine myoblast progenitor C2C12 cell line. Upon polyamine treatment of C2C12 cells during induction of myogenic differentiation, the number of myotubes significantly increased. Morphologically, polyamine-treated myotubes exhibited elongated cell body and contained larger amount of nuclei in the cell. On the other hand, the polyamine did not have influence on myoblasts proliferation. Furthermore, compensatory muscle hypertrophy of C57BL6 mice that underwent sciatic nerve transection of the left hindlimb was enhanced by administration of polyamines. Therefore, our study demonstrates that polyamines may play an important role in regulating myogenic differentiation rather than myoblasts proliferation.
AssuntosAlimento Funcional , Mioblastos , Animais , Homeostase , Camundongos , Camundongos Endogâmicos C57BL , Músculo Esquelético
BACKGROUNDS AND AIMS: Prevention of cardiovascular (CV) disease is considered a central issue in public health and great attention is payed to nutritional approaches, including consumption of functional foods to reduce CV risk in individuals without indications for anti-atherosclerotic drugs. Cholesterol efflux capacity (CEC) is an important anti-atherogenic property of HDL and a marker of CV risk. We evaluated the effect of a daily consumption of an innovative whole-wheat synbiotic pasta, compared to a control whole-wheat pasta, on serum ATP binding cassette G1 (ABCG1)-mediated CEC in healthy overweight or obese individuals. METHODS AND RESULTS: Study participants (n = 41) were randomly allocated to either innovative or control pasta, consumed daily for twelve weeks. Serum CEC was measured before and after the dietary intervention, by a well-established radioisotopic technique on Chinese Hamster Ovary Cells transfected with human ABCG1. The innovative synbiotic pasta consumption was associated to a significantly higher post treatment/baseline ratio of ABCG1-mediated CEC values with respect to control pasta (mean ratio 1.05 ± 0.037 and 0.95 ± 0.042 respectively, p < 0.05). Analysis of the relationship between ABCG1-mediated CEC and glycemia, homocysteine, total folates and interleukin-6 showed specific changes in the correlations between HDL function and glycemia, oxidative and inflammatory markers only after synbiotic pasta consumption. CONCLUSION: This is the first report on serum CEC improvement obtained by a new synbiotic functional pasta consumption, in absence of lipid profile modifications, in overweight/obese participants. This pilot study suggests that a simple dietary intervention can be a promising approach to CV preservation through improving of athero-protective HDL function.
AssuntosMembro 1 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/sangue , HDL-Colesterol/sangue , Dieta Saudável , Alimento Funcional , Obesidade Metabolicamente Benigna/dietoterapia , Simbióticos/administração & dosagem , Grãos Integrais , Adulto , Idoso , Biomarcadores/sangue , Feminino , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Obesidade Metabolicamente Benigna/sangue , Obesidade Metabolicamente Benigna/fisiopatologia , Projetos Piloto , Método Simples-Cego , Fatores de Tempo , Resultado do Tratamento , Grãos Integrais/metabolismo
Nuclear factor erythroid-derived 2-like 2 (Nrf-2) is transcription factor implicated in the antioxidant response element-mediated induction of endogenous antioxidant enzyme such as heme oxygenase-1 (HO-1), glutamate-cysteine ligase, and NAD(P)H quinone dehydrogenase 1, among which HO-1 is an enzyme catalyzing the degradation of heme.producing biliverdin, ferrous iron, and carbon monoxide. In the stomach, as much as regulating gastric acid secretions, well-coordinated establishment of defense system stands for maintaining gastric integrity. In previous study, author et al. for the first time discovered HO-1 induction was critical in affording faithful gastric defense against various irritants including Helicobacter pylori infection, stress, alcohol, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, and toxic bile acids. In this review article, we can add the novel evidence that dietary walnut intake can be reliable way to rescue from NSAIDs-induced gastrointestinal damages via the induction of HO-1 transcribed with Nrf-2 through specific inactivation of Keap-1. From molecular exploration to translational animal model of indomethacin-induced gastrointestinal damages, significant induction of HO-1 contributed to rescuing from damages. In addition to HO-1 induction action relevant to walnut, we added the description the general actions of walnut extracts or dietary intake of walnut regarding cytoprotection and why we have focused on to NSAID damages.
AssuntosAnti-Inflamatórios não Esteroides/efeitos adversos , Alimento Funcional , Gastroenteropatias/induzido quimicamente , Gastroenteropatias/terapia , Juglans , Animais , Alimento Funcional/análise , Mucosa Gástrica/efeitos dos fármacos , Mucosa Gástrica/patologia , Gastroenteropatias/patologia , Humanos , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Juglans/química , Juglans/metabolismo
In the present work, amaranth proteins were used as a functional ingredient of formulated food. An amaranth lemon sorbet, a healthy alternative dessert for celiac, vegan and any consumer that chooses to follow a conscious diet, was elaborated and characterized. The sorbet base mixture behaved like a pseudoplastic and thixotropic fluid, with a Kokini viscosity of 0.42 ± 0.07 Pa.s, a suitable value for elaborating products with good thickness characteristics. Aeration rate of the sorbet was 36.15 ± 3.48, an overrun value within the expected range of 30-50%, indicating that amaranth proteins presented adequate foaming properties in low pH elaboration conditions. Moreover, the stability study showed that the sorbet did not suffer significant changes in its structure over time during the first two months of storage at -20 °C. Sensory evaluation evidenced panelists accepted the product (8 ± 1, acceptability assay) and related it with airy, creamy and healthy attributes (CATA assay). Finally, simulated gastrointestinal digestion was able to release peptides capable of inhibiting fibrin clot formation (IC50 = 3.4 ± 0.1 mg protein/mL), demonstrating that amaranth proteins could be used as a good foaming ingredient in the elaboration of potential functional foods with antithrombotic activity.
AssuntosAmaranthus , Citrus , Digestão , Alimento Funcional , Peptídeos
The widespread use of health foods, including supplements, is now common among patients. This is because many health foods are being claimed to be beneficial. If patients use medicines and health foods concurrently, the interaction between the two might lead to adverse events. Additionally, it is reported that pharmacists do not generally care about health food use in their patients, because they also lack sufficient knowledge about health foods. On the contrary, there are some licenses to be a health food advisor in Japan, and the generic name of these licenses is "advisory staff". Pharmacists who have this license are specialists in both medicines and health foods, and thus, they might pay more attention to the concurrent use of medicines and health foods compared to those who do not have the advisory staff license. To address this issue, we conducted a study with an online questionnaire about health food consultation, and 87 pharmacists with advisory staff license participated. Only 36.8% of participants were found to always ask their patients about health food use. However, 92.0% of them had experience of consultation about the simultaneous use of medicines and health foods, and 17.2% of them recognized adverse events by knowing about the concurrent use. Patients who experienced adverse events have used either eicosapentaenoic acid/docosahexaenoic acid supplement with epadel or Ginkgo biloba extract with warfarin. Therefore, an active interview with pharmacists is important to avoid such adverse events in patients.
AssuntosSuplementos Nutricionais , Interações Medicamentosas , Interações Alimento-Droga , Alimentos Especializados , Alimento Funcional , Licenciamento , Farmacêuticos , Encaminhamento e Consulta , Suplementos Nutricionais/efeitos adversos , Ácidos Docosa-Hexaenoicos/efeitos adversos , Ácido Eicosapentaenoico/efeitos adversos , Alimentos Especializados/efeitos adversos , Alimento Funcional/efeitos adversos , Humanos , Japão , Conhecimento , Extratos Vegetais/efeitos adversos , Encaminhamento e Consulta/estatística & dados numéricos , Inquéritos e Questionários , Varfarina/efeitos adversos
BACKGROUND: Traditionally part of the human diet, plants with edible fleshy fruits (PEFF) contain bioactive components that may exert physiological effects beyond nutrition, promoting human health and well-being. Focusing on their food-medicine functionality, different ways of using PEFF were studied in a cross-sectional way using two approaches: a bibliographical survey and an ethnobotanical case study in a rural community of Patagonia, Argentina. METHODS: A total of 42 studies were selected for the bibliographical review. The case study was carried out with 80% of the families inhabiting the rural community of Cuyín Manzano, using free listing, interviews, and participant observation. In both cases we analyzed species richness and use patterns through the edible consensus and functional consensus indices. Local foods, ailments, medicines and drug plants were also registered. RESULTS: The review identified 73 PEFF, the majority of which (78%) were native species, some with the highest use consensus. PEFF were used in 162 different local foods, but mainly as fresh fruit. Of the total, 42% were used in a functional way, in 54 different medicines. The principal functional native species identified in the review were Aristotelia chilensis and Berberis microphylla. In the case study 20 PEFF were in current use (50% were native), and consensus values were similar for native and exotic species. These were used in 44 different local foods, mainly as fresh fruit. Only 30% were recognized for their functional value by inhabitants (mainly as gastrointestinal and respiratory treatments). The species with the highest functional consensus were the exotic Sambucus nigra and Rosa rubiginosa, followed by the native A. chilensis, Ribes magellanicum and B. microphylla. Infusions also constituted important local functional foods. CONCLUSIONS: This survey highlights the importance of studying the different local functional foods to depict the biocultural diversity of a human society. The preparation of different beverages and herbal medicines was relevant, and would be a promising subject to investigate in the future. The living heritage of PEFF appears to have undergone hybridization processes, such that exotic species play an increasingly significant role.
AssuntosFrutas , Alimento Funcional , Medicina Tradicional , Plantas Comestíveis , Plantas Medicinais , Argentina , Estudos Transversais , Humanos , População Rural
In order to reveal the main nutrients and functional ingredients in the shoots of Polygonatum cyrtonema, the polysaccharides, proteins, amino acids, and total phenols were determined. The tested samples cultured in Ma'nijiaonong, Hengtang village, Tianmushan town, Lin'an, Zhejiang, which were collected from three provenances(Pan'an and Longquan in Zhejiang and Qingyang in Anhui). The results showed that the polysaccharide content of the shoots varied from 2.34% to 12.73%, roughly one-third of rhizomes. The protein content varied from 107.75 to 192.49 mg·g~(-1), nearly 5.50 times more than rhizomes. Moreover, the average of total amino acid content was 193.13-248.74 mg·g~(-1), approximately 4.16 times of rhizomes. And the essential amino acids account for 35.57%-39.44% of the total amino acids content, which was close to the standard of the ideal protein proposed by FAO/WHO(the essential amino acid/total amino acid is about 40%). In addition, the taste amino acids(TaAA) changed from 160.12 to 208.29 mg·g~(-1), revealing the material basis of "shoots were extremely delicious" in Chinese ancient herbal medicine. Additionally, the total phenols varied from 51.21-58.76 mg·g~(-1), about 2.96 times of rhizomes. The DPPH free radical scavenging rate of tested shoots was over 95%, which obviously superior to rhizomes. Therefore, the shoots of P. cyrtonema is a very high-quality vegetable and functional food with good development potential. Furthermore, the main nutrients and functional substances in P. cyrtonema shoots are closely related to the provenances and harvesting seasons. It is important to improve the quality and yield of the shoots by strengthening the variety of breeding and cultivation techniques.


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Freed 'Willy ' now part of Oregon Coast Aquarium's aquatic crowd
Several previous stories in R&R have mentioned the Oregon Coast Aquarium in Newport as a worthwhile stop on any visit to Oregon's north central coast.
The aquarium, on Yaquina Bay just south of the big bridge on Hwy. 101, opened just a few years ago but is constantly evolving.
It's indoor exhibit areas focus well on the ecosystems of the Northwest Coast and the exhibits on kelp and jellyfish are particularly well implemented. Outdoors, there are sea otters, seals and sea lions, and a great place to observe seabirds, including tufted puffins.
The newest exhibit, just opened in January, is the home of Keiko, the orca whale who was the star of the movie "Free Willy."
Keiko, who had been housed in a small, warm water tank at a Mexico City amusement park, moved to Newport on Jan. 7. His physical condition is already is reported to have improved markedly since his move to the Oregon Coast Aquarium.
While his tank was closed to visitors for the first week while he was acclimated, it is now open. Hundreds of school children from the area have already visited "Willy."
Jeff Brody


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Don Andres Hurtado de Mendoza, marquis of Canete, entered Lima as third viceroy of Peru on the 6th of July 1555, and ruled with an iron hand for six years.
A born ruler, Casimir introduced a whole series of administrative and economical reforms. He was the especial protector of the cities and the peasants, and, though averse from violent measures, punished aristocratic tyranny with an iron hand.
To escape from these preoccupations and prejudices except upon the path of conscious and deliberate sin was impossible for all but minds of rarest quality and courage; and these were too often reduced to the recantation of their supposed errors no less by some secret clinging sense of guilt than by the church's iron hand.
employed; all his work was carried out by the iron hand of authority.
collectivized agriculture, his iron hand that applied Bolshevik mercilessness.


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World Book Day Winners
Year 4 are learning about mummification and how the Ancient Egyptians preserved bodies.
To test this process, Year 4 followed instructions, making their own natron and mummified fruit using salt and bicarbonate of soda.
Fantastic Harley, you are my Star of the Week. You deserve this award so much Harley for all your hard work. You are really working hard with your handwriting, a pleasure to have in class and you are a good friend to everyone!
We have investigated how shadows change shape with distance from the light source.
© Copyright 2013–2020 St Hugh of Lincoln RC Primary


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I went to college with her. Your crush was well justified - she's a lovely person. :)
I've met "the one" 15 times I'd say ☺
We'll check in with you next week 😝
I feel good about this. Bourbon burst is A+++
Of course. There's always room for improvement. But to pretend there has been no progress is a slap in the face to the generations of people before us who fought (and often gave their lives) for change - and they succeeded. Ask anyone alive who remembers what real segregation was like. There are plenty of them around who remember.
oh ffs. there's been zero progress? pick up a history book.
Oh man that dog is cute
I'm assuming this is a 13 year old boy wondering, since my (admittedly sexist) gut tells me girls care less about this kind of thing.
A few observations:
"Good enough" is subjective. What's good for you will be different than what's good for me. When I was 13 I was the tallest kid in my grade and I hated it. I have always hated being tall. So what's "good" to you?
According to Google, you are 4" above average for your age. By the time you are your friend's age, you could grow another half a foot, which brings you to just shy of 1.8m. By the time you're done growing, I'm guessing you'll be close to 1.85m. Is that "good?"
My response would be different if you were a parent.
The 13 year old?
Who's asking?
Start on youtube - look for "how to scream" vocal coaching
Idiots of the world: leave my Animaniacs alone!!!
man that baby is super old
/s? Dave Rubin was captured by his crazy right wing nutbag trumper audience years ago. Lost cause.
I want to come over. But I don't want to stay too long.
I remember these! Super cool to look at, but uncomfortable rough plastic texture.
Who had the transformers ones that also came with a tent that attached to your bed? :D
I wanted one of those green mercury guitars so bad.
Maybe you... also have a stick... :X
What's in it?
Me too!
Can you give us some examples of what you're calling indie / emo guitar tones?
I need a diagram.
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