text:
I mentioned over on the Firefox Blog about a thread in the Thunderbird Builds forum asking if there is a possibility of being able to have toolbar (icons) next to the tabs like in Firefox. They posted the following mockup of how they would like this to look in Thunderbird (note they are using Small Icons and have the 'Show:' setting as Icons):
At first I really didn't understand what they were asking or why you want to do this. However, the more I got to looking at this, the more I would like to see this feature. This is a nice way to clean up wasted space in Thunderbird (especially just using 'icons' only) and provides a cleaner looking interface as well.
While nothing official has been posted there has been discussions in tb-planning about changing the UI in Thunderbird. However, given Thunderbird 5 has already reach the feature freeze point (of course technically so has Thunderbird 6 if they are following the Firefox release schedule) the earliest we could see this would be Thunderbird 7 or possibly Thunderbird 6?
I have not yet had a chance to take a look the pre-release version of Thunderbird 6 (if there is one yet) or the current Nightly builds which are 7.0. I'll try to take a look these in the coming days to see what changes have been made.


text:
Cakewalk has released version 7.0.2 of their DAW software SONAR (Producer Edition & Studio Edition).
New features in SONAR v7.0.2
- Step Sequencer
- Save and load SONAR Step Sequencer pattern files.
- New mouse gestures to edit velocities in the steps pane.
- Change/set default velocity of new steps.
- Step record from MIDI devices.
- Option to audition notes when clicking on steps.
- Preserve patterns when changing step sizes.
- Main Application
- Auto-fade playback when starting/stopping the transport.
- Option to automatically enable input monitoring when recording.
- Euphonix EuCon
- Cakewalk has released a Control Surface plug-in supporting the Euphonix EuCon protocol, compatible which now makes SONAR compatible with all Euphonix Control Surfaces.
- Many issues resolved.
Visit Cakewalk for more information.

subset: commoncrawl


text:
Alexa Devices
We're keeping up with Smart Speaker technology at the Living Bread Radio Network. We now offer an exclusive Alexa Skill. What that means is with your Alexa enabled device, all you have to say is "Alexa, ENABLE Living Bread Radio" then "Alexa, PLAY Living Bread Radio", and she'll do the rest. Once you enable Living Bread Radio, you'll be ready for any added features that we add in the future. You only have to "ENABLE" Alexa one time, then all you have to say is "Alexa, PLAY, or Alexa OPEN Living Bread Radio"
Google Home Devices
Currently Google Home Devices default to Tune-In Radio where Living Bread Radio is available. So here's how to listen through Google.
Say "OK Google, play Living Bread Radio Network"
This seems to work in most instances.


text:
In this do-it-yourself culture, where a website can be made by anyone with those annoying can-do attitudes, yours has to stand out. Quality, creative, and professional websites and commercials are the keys to making a lasting impression—the good kind that is. That's where Strillogy comes into play. With over 17 years in the industry, Strillogy Productions will help you and your company become unique and innovative.
It's simple. A unique business like yours needs unique solutions. Our promise is to always find the most creative and professional solutions for your business in a manner that's as painless as possible. We're not going to just be "creative for the sake of being creative". We're going to develop a site that's tailor-made for your one-of-a-kind business.
Lowell is skilled in all areas of production from pre to post. He's produced numerous TV commercials, developed entire network branding packages, and created several teaching tools for both education and corporate industries.
Trey graduated with a Bachelors degree in computer science from the University of Utah, and loves to build amazing software. If it runs some form of code, Trey can program for it, but he specializes in developing server-side APIs, Mobile Apps, and Web Apps. Trey has a unique ability to understand development at a very deep level, but still be able to communicate at a very high level with anyone. When Trey is not working, he's with his family at the beach, surfing and having fun.
Brent's photography has appeared in Dwell magazine, Salt Lake Magazine, Slug Magazine and Western Art and Architecture, among other publications. He's shot numerous commercial spots.
Nick holds a Bachelors degree from Brigham Young University in Fine Arts and Character Animation. He's spent several years with Disney Interactive (animation and illustration). His strengths are in Maya, Adobe After Effects, Adobe Illustrator and Adobe Photoshop.
Nuts and Bolts
"Our company has grown in leaps and bounds over the course of the past three years, and I can honestly say that without the insight and talent at Strillogy it simply would not have been possible."
Jenny Phillips
"I always know that I will get something I love when I work with Lowell. Not only is he talented and versatile, but his expertise always helps my projects go smoothly and quickly."
Development Center
"Strillogy Productions has helped our organization's website, videos, and manuals become more relevant, responsive, and respected across the Utah public education community! In working with their team, we felt we were their most important client. The willingness to listen, response time, and understanding of 21st century communication is exceptional."


text:
Fullsize Titflash Display
Zen's Age: 36 - 42 years
Submitted from: Indonesia
Titflash Photo ID: 10556
Rate Tits : This Photo of Zen's Medium Tits is
Search for more Tit Photos from Zen
Medium tits Natural tits Tits from Indonesia
luv to suck ur tits and ur pussy
May 9, 2017, 10:59 pm
mau tukar foto:sy cewe jkt ingin tukar foto dgn kamu email sy ya dewisanjaya @rocketmail.com
November 25, 2010, 7:50 pm
crazy:fuck you zen..
i love the nipples !!
September 24, 2010, 5:45 am
yes:I'd love to. They look so delicious!!! Lezat in bahasa?
September 15, 2010, 11:20 pm
cantik:tetek yang sangat cantik. hantar lah sikit ker firstname.lastname@example.com
August 21, 2010, 6:06 pm
Love your tits!:yummy, would love to suck your nips! bet they taste like a spicy hershey kiss. You still in IDN? contact me: email@example.com
July 24, 2010, 10:05 pm
great tits:great tits..teteknya bagus banget zen...mau ketemuan ?
sayariza3 at yahoo.com
May 13, 2010, 2:57 am
Wowwwwww:Wowwww..i would like to suck your nips Zen! Those nipples are gorgeous! and sexy! Send me more pleaseee~ firstname.lastname@example.com
April 30, 2010, 8:05 pm
indah sekali:this is one of the sexiest and real nipples I ever seen....want to suck it deep & make love to u cantik !
i louv u !
harry, indonesia 2
April 30, 2010, 2:19 am
Hi Zen, contact me! xx:WOW! - I just wanted you to know that you ve made my day hunny! - I voted you superb, cause you are sex on legs! - you are a real fox and a total natural with THE most amazing big dark ruby nipples, which really do it for me!!! - if you wish to keep in touch, then my addy is firstname.lastname@example.com - hope to hear from you Zen. Mwah. Rainbow xx
April 29, 2010, 9:10 pm
Suckable!:Love to suck your nips and areolas really hard and pull on them. I'd put my mouth around your big dark rings and suck hard while I use my tongue to lick and caress your rock hard nipples. I'd do this til you came just from my mouth on your tits! firstname.lastname@example.com
April 29, 2010, 10:46 am
Can i Suck them?:You have very sexy breasts. I'd love to chat with you! You can IM me on yahoo messenger if you'd like collegemale4fun_now. or E-mail me at email@example.com
April 29, 2010, 5:46 am
perfect nipples -- make it bigger!!
i'll spray my sperms all over yournice pretty tits bitch !! i wanna fuck youu
April 29, 2010, 5:30 am
9":you indian girls nipples rock always scrumtous,keep them firstname.lastname@example.com
April 29, 2010, 1:21 am
Nipples!!:What great nipples you have. Love them dark and perfectly round ... just like yours
April 28, 2010, 10:40 pm
OH!:Love those dark nipples and oversize areola. Sweet. What do they look like after a good sucking?
April 28, 2010, 9:57 pm
WOW!!! Great big dark nips are a turn on for sure!!! More please!!
April 28, 2010, 9:46 pm
Start with your areolas:They're lovely....lick my way around them and then suck your nipples.
April 28, 2010, 9:40 pm
HELL YES:Of course I'd like to suck on those beautiful dark nipples....WOW. Of course I'd like to shoot my hot white cum all over them too ;o) firstname.lastname@example.com
April 28, 2010, 9:27 pm
Yes, I wouldlike to suck on your pretty nipples. I want you to post more pictures.
April 28, 2010, 9:25 pm
Our titflash pages are under heavy reconstruction. Some pages still have the old layout and will appear under the new layout soon. Please apologize the dust.
Voyeurclouds and VCity are our main adult lifestyle platforms. Join the fun and see hundreds of instant adult lifestyle and voyeur postings at VCity now.
We tolerate real amateur posters only. No lame internet copies - real pics and videos from real people only!
Please explain in a few words why this photo is not appropriate:


text:
Mattituck-Laurel: "Footloose" opens at NFCT July 28
Weddings are often the high point of summer activities. Bridal showers, rehearsal dinners and ceremonies and receptions fill our calendars and put smiles on our faces. Best wishes to all the brides and grooms who chose this wonderful season on the North Fork to tie the knot.
July 16 is Adrienne Rehm's birthday — and what better gift than watching her daughter Shannan walk down the aisle on her wedding day? Shannan will exchange vows with Kevin Maida at Our Lady of Good Counsel Church with a reception immediately following at Calverton Links. I saw her dad, Chris, the other day and he remarked that he can remember walking Shannan to the bus stop on the first day of school and now he'll be walking her down the aisle. Time passes so quickly! May the day bring memories to last a lifetime!
Weddings continue to take center stage next week, when Christina D'Eletto and Jason Wesnofske join hands and hearts at St. Isidore Church. The couple will celebrate, surrounded by family and friends, with a reception at Majestic Gardens after exchanging vows. May your life together be full of love and laughter.
Celebrating birthdays this week are Eric Shaw on the 14th; Laura Kelly and Maria Ulmet on the 18th; and Kyle Steele and Dustin Strauss on the 20th.
Best wishes to Megan Bundrick, daughter of Linda and Bill Bundrick, who is in Oklahoma studying to be an air traffic controller. Megan is a 2005 graduate of Mattituck High School.
Congratulations to my daughter, Vanessa Arslanian, who has been invited to be a staff writer for Boston College Law School's International and Comparative Law Review. Vanessa will begin her second year in law school in September and is currently completing an internship in the Queens District Attorney's office.
You could tell from the many cars parked along Main Road last Saturday that the Love Lane Street Fair was once again a huge success. One of the many highlights was the crowning of Little Miss and Mr. Mattituck. Congratulations to this year's winners, Torrance Shipman and Paul LoCascio.
If you've never seen a Youth on Stage production at North Fork Community Theatre, you're truly missing one of the gems of the North Fork. This year's production, "Footloose," promises to be a fun, entertaining experience. For tickets, call 298-NFCT. The show opens July 28.


text:
An homage to CO. and DiPalo Dairy Store in Little Italy
Now I won't say this place actually reminded me of my old haunts in Rome which were more Salumerias than Dairy outposts. But it is exclusively Italian down to the Illy coffee that was being sampled along with rounds of Gran Padano, that cousin of Parmigiano that's grainier and less well known. DiPalo continues that wonderful Italian tradition of letting you sample virtually everything you buy.
We were treated to paper thin slices of prosciutto that literally melted in our mouths and we got to taste our cheeses. The cheese selection at DiPalo is fantastic and I think, well priced. I got Pecorino Romano for $12.00 a pound and Gran Padano was on offer at 11.99. Then there was, at 7.99 for 500 grams or 1.1 lbs., the all-important Stracciatella, yet another cousin, this time of mozzarella, that's the basis for my homage to Co., the new pizza place at 230 Ninth Avenue and 24th Street (212-243-1105).
And there's also a little nod (in the use of the prosciutto) to the spectacular "Parma" pizza at World Pie, 2402 Main Street in Bridgehampton (631 537 7999), which is one of our all-time favorites.
It makes a lot of sense that pizza would take off in this economy. It is an inexpensive luxury although I am not sure a 12 inch pie like the ones at CO. (pronounced Company, by the way) coming in at $17.00 can be considered that inexpensive. But you can certainly get in, have a couple of glasses of screw-top wine and get out for about $35.00 a piece.
Co. already has a huge following and doesn't take reservations but at lunch, it's a snap to get a table and, jammed as the place was when we went for a weeknight dinner, we got seated immediately.
You must use a pizza stone, parchment paper and a dough that uses all-purpose rather than bread flour. This is because bread flour has a higher protein content and retains less moisture.
In a restaurant pizza oven, the 800 degree temperature zapa everything so that the crust browns and the toppings melt before the dough dries out. In a home oven where you might get a temperature of 500 degrees, a bread flour crust will dry out.
To make Stracciatella and Prosciutto Pizza with Arugula and Tomato Sauce, you will need:
However, because the dough is such a key part of making this pizza, I wanted to include a recipe for it. I've combed the blogs and recipe sites and this one makes a great deal of sense. It's from Cook's Illustrated and the general consensus is this is the best recipe for at-home pizza crust.
One caveat: You should make the dough and let it rest in the refrigerator overnight or up to 48 hours before you use it. I've included instructions for creating dough you can use instantly. But I promise you this is true proof that the best things in life come to those who wait.
On the other hand, a freshly processed dough that is too dry will form a clean ball, feel more oily than moist, and look slightly curdy on the surface.
To moisten a processed dough that is too dry, add 1 teaspoon water and throw the dough against the counter 10 times. The dough may take up to 2 teaspoons additional water.
A properly kneaded dough with enough water will be supple and fine-textured. Though moist and sticky, the dough should have structure and not feel "batter-like."
Now that tomato season is past, here at least, it's reassuring to know that everyone from Marcella Hazan on down touts using canned tomatoes when tomatoes are not in season. So don't fret about fresh versus canned.
You can decide if you want to spring for San Marzano tomatoes at about twice the price of Red Pack, the ones I use.
There's good reason to spring for the Italian imports. They are grown very close to Naples, and Naples, if it didn't invent pizza, certainly gave me my first taste of a genuinely fantastic pie.
Or you can be completely indolent and go with your favorite store-bought Marinara Sauce. I can personally vouch for any one of Newman's Own All-Natural Pasta Sauces.
Recipe for Quick and Spicy Tomato Sauce
½ cup finely chopped onion
2 garlic clove, minced
½ cup white wine
2 tbsp. tomato paste
2 tsp. dried oregano
1 tsp. crushed red pepper
¼ tsp. freshly ground black pepper
1- (28-ounce) can crushed tomatoes in puree
1 tsp. balsamic vinegar1 Heat a large saucepan over medium-high heat. Add olive oil to heated pan
2 Add onion to pan; sauté 3 minutes or until tender. Add garlic to pan; sauté 30 seconds. Stir in wine; cook 30 seconds. Add tomato paste, oregano, crushed red pepper, black pepper, and tomatoes.
3 Reduce heat, and simmer for 20 minutes or until thick. Remove from heat; stir in vinegar. Cool.
4 This will yield about 2 2/3 cups of tomato sauce.
To make the pizza:
1. Adjust oven rack to lowest position, set baking stone on rack, and heat oven to 500 degrees. Heat baking stone 1 hour before proceeding.
2. Remove dough from plastic bag and divide in half with pastry scraper. Set each half in center of lightly floured large sheet parchment paper. Flatten the each dough lump into a circle. Neatness doesn't count here. If the pizza isn't a round, it will be just as delicious.
3. Setting one dough aside, roll the other dough into a 14-inch round with even thinness of 1/32-inch. You can make your life easier by putting a second piece of parchment paper on top of the dough and using your rolling pin directly on the parchment. With scissors, trim excess parchment so that it is just larger than dough. Using a fork, make multiple tiny holes in the dough so that it will keep its flat shape.
4. Slip dough with parchment onto inverted rimmed baking sheet, or rimless cookie sheet, then slide onto hot pizza stone. Bake 4 minutes. Remove from oven. Top with tomato sauce, then about 1/8 of the stracciatella and finally ½ the prosciutto slices. Return the pizza to the oven and cook an additional 8 minutes under a watchful eye—your pizza make take less or more time depending on how hot your oven is and how thick your toppings are.
5. Transfer pizza to cutting board, slide parchment out from under pizza. Spoon spoon stracciatella over the prosciutto. Cover the pie with a handful of arugula, a couple of grinds of the pepper mill and a little salt.
6. Cut pizza into wedges and serve.
7. While first pizza is baking, repeat steps 3 and 4 to roll and sauce the second pizza; allow baking stone to reheat 15 minutes after baking first pizza, then repeat step 5 to bake the second pizza which for some reason you will be ravenous for after you've tasted the first.
8. This serves 2. I am sure you can double or triple the recipe without any problem at all.


text:
Yoga shows us that our bodies are able to do amazing things. Yoga also shows us how to observe our bodies in the moment that it's doing the amazing act. Yoga is all about amazing moments of personal accomplishment. If this video doesn't give you a burst of empowerment and an urge to ramp something, nothing will.
P.S. Check out the first guy doing a sweet jump in a wheel chair… hello motivational. Oh and be sure to check out the yogi-contortionists at 3:12 and 4:01!
Check out the Places to Yoga & Manduka Amazing Yoga Gear Giveaway… Someones gonna win, and it might as well be you!


text:
Morwell Power Station & Briquette Factories have been determined cultural heritage of significance to the State of Victoria and should be included in the Victorian Heritage Register.
While heritage advocates will be over the moon, we can expect a major fallout from this as Latrobe Valley anti-asbestos groups are outraged.
Not only are these sites a major eye-sore but questions need to be asked who is responsible for the maintenance and upkeep costs of these sites.
What are your thoughts on the decision?


text:
Global healthcare systems will have to move more into early health and the use biomarkers if they want to survive financially in the future, a meeting held at the embassy of Sweden in London on Friday May 13 has heard.
The event, hosted by the Stockholm-Uppsala region of Sweden, heard that the ideal scenario would be that biomarkers are used regularly to test people for diseases to catch them in early stages or before they occur and treat them.
However, current efforts put into this field are limited and as a result, little new technology is being developed. Daniel Mahony, fund manager at Polar Capital, said: "Financial firms are not investing in diagnostics because it is not interesting to them. It is insurance companies and governments that will invest because it is a way to save money."
The meeting also heard about the growing antibodies market. Lotta Ljungqvist, head of R&D BioTechnologies, Life Sciences at GE Healthcare Sweden, said: "There will be more protein-based drugs available commercially within the next two years, which will be transferred through to the copycats."
She predicted that within 20 years the healthcare system will be able to treat almost every disease, stating "there is so much going on in this area." There are currently 20 protein-based drugs on the market.
The meeting heard that antibodies are easier to manufacture than molecules and that their popularity is growing, moving to India and China.
The purpose of the event was to promote the Stockholm-Uppsala region and the technologies it is developing. The region has already attracted AstraZeneca, GE Healthcare and Pfizer and participates in one third of all EU funded life sciences and protein research projects.
Andreas von Beckerath, minister counsellor for Sweden, said: "Sweden has been successful [in this area] because it invests 4 per cent of GDP into science, which is one of the highest in Europe.
"Also we are open-minded and we collaborate between academic and corporate sectors," he said.
We are a specialist health communication agency creating powerful and trusted content. If you're looking for a partner to help...


text:
Top Items:
Iraqi official: Al-Qaida in Iraq leader wounded — Al-Masri reportedly hurt, in custody; aide slain in skirmish north of Baghdad — BAGHDAD, Iraq - The leader of al-Qaida in Iraq was wounded and an aide was killed in a clash Thursday with Iraqi forces north of Baghdad, the Interior Ministry spokesman said.
Discussion: Counterterrorism Blog, Ace of Spades HQ, Anti-Idiotarian Rottweiler, digg, Blue Crab Boulevard, Macsmind and In the Bullpen
Andrew Cochran / Counterterrorism Blog: Capture of Leader of Al-Qaeda in Iraq: Wait Until the U.S. Confirms It
Emperor Misha I / Anti-Idiotarian Rottweiler: Leader of al-Qaeda in Iraq Wounded, in Custody... Well, No He Isn't (UPDATED x2)
Gaius / Blue Crab Boulevard: Potentially Huge News
Macranger / Macsmind: Al Qaeda on the run and bleeding
Pajamas Media:
ABU AYUUAB AL-MASRI STILL AT LARGE. "NO DNA MATCH" — INTEL OFFICER — ABU AYUUAB AL-MASRI STILL AT LARGE. "NO DNA MATCH" — INTEL OFFICER — PJM in Seattle — Abu Ayuuab al-Masri. — In the sights, but still at large. — Media reports that the leader of al Qaeda in Iraq …
Richard Mauer / Kansas City Star:
U.S. and Iraqi forces raid leading Shiite mosque in Baghdad — BAGHDAD, Iraq - A U.S. military spokesman on Thursday hailed a joint American-Iraqi raid on Baghdad's leading Shiite Muslim mosque as proof of that the Baghdad security plan is being applied evenly against all sides of the country's sectarian divide.
Discussion: Right Wing Nut House and Mudville Gazette
Rick Moran / Right Wing Nut House: THE GLOVES ARE OFF IN BAGHDAD
Greyhawk / Mudville Gazette: COLLECTIONS
Iraqi terror leader reported wounded
Iraqi terror leader reported wounded
Discussion: PrairiePundit, Andrew Olmsted, Outside The Beltway, On Deadline, Decision '08 and PoliBlog (TM)
James Joyner / Outside The Beltway: Al Qaeda in Iraq Leader Wounded, Deputy Killed
Michael Winter / On Deadline: Reports: Al-Qaeda leader in Iraq wounded
Dr. Steven Taylor / PoliBlog (TM): Breaking News: al Qaeda in Iraq Leader Wounded.
Allahpundit / Hot Air:
Breaking: Al Qaeda in Iraq leader wounded in firefight? …
Breaking: Al Qaeda in Iraq leader wounded in firefight? …
Discussion: The Belmont Club, The Heretik, The Jawa Report, Captain's Quarters, The Political Pit Bull, alphabet city and Pajamas Media
Ed Morrissey / Captain's Quarters: Al-Qaeda In Iraq Leader Captured By Iraqi Forces
Robert / alphabet city: Breaking: Al Qaeda in Iraq Leader Wounded, Top Aide Killed; Update: False Alarm
David S. Broder / Washington Post:
Bush Regains His Footing — It may seem perverse to suggest that, at the very moment the House of Representatives is repudiating his policy in Iraq, President Bush is poised for a political comeback. But don't be astonished if that is the case. — Like President Bill Clinton …
Discussion: Right Wing Nut House, Outside The Beltway and Don Surber
Rick Moran / Right Wing Nut House: READY FOR THE "BUSH BOUNCE?"
James Joyner / Outside The Beltway: Bush the New Comeback Kid?
Joe Gandelman / The Moderate Voice: Broder: George Bush Has Regained His Political Footing
Ken Allard / MySanAntonio.com:
NBC sinks too low for this talking head — Like some second marriages and most Hollywood sequels, it's usually a bad idea for a columnist to revisit the same topic. But last week's discussion of renegade blogger and NBC military analyst Bill Arkin proved some larger points.
Discussion: Andrew Olmsted, Hot Air, Blue Crab Boulevard, NewsBusters.org and Ed Driscoll.com
Allahpundit / Hot Air: Arkin fallout: Col. Ken Allard quits NBC in disgust
Matthew Sheffield / NewsBusters.org: NBC Military Analyst Quits Network, Citing Left-wing Bias
Howard Kurtz / Washington Post:
A Hard Right Punch — Michelle Malkin's Conservative Fight Has Others Coming Out Swinging — Michelle Malkin has seen her head electronically grafted onto a photo of a bikini-clad body. — She had to cancel a Berkeley book signing in the face of 200 shouting protesters. — YouTube banned one of her videos.
Discussion: Captain's Quarters, Sadly, No!, Hot Air, NewsBusters.org and Rising Hegemon
Brad Altrocket / Sadly, No!: Nice Love Letter, Howie
See-Dubya / Hot Air: WaPo's Kurtz Profiles Lonely Outspoken Conservative Who Brings It All On Herself
Ken Shepherd / NewsBusters.org: Wash Post's Kurtz Profiles Michelle Malkin
Attaturk / Rising Hegemon: Things you learn on the internets
Jules Crittenden:
Good News Bad News — Lots of news from and about Iraq, Iran, Waziristan, all these places. Good, bad, ugly and irrelevant. How's it stack up? Let's have a look: — Good news from Iraq: al-Zarqawi's replacement wounded and a top aide killed, Iraqi officials say.
Lee Keath / Associated Press:
Elite Iranian Corps Enmeshed in Iraq
Elite Iranian Corps Enmeshed in Iraq
Discussion: The Corner and Don Surber
Jonah Goldberg / The Corner: Quds, The AP & Totalitarian Regimes
Jennifer Steinhauer / New York Times:
Democrats in State Capitols Push Antiwar Resolutions — Frustrated by the inability of Democrats in Congress to pass a resolution opposing President Bush's policies in Iraq, state legislators across the country, led by Democrats and under pressure from liberal advocacy groups, are pushing forward with their own resolutions.
Paul Kane / Capitol Briefing:
Rep. Jefferson Gets Seat on Homeland Security — Rep. William Jefferson, the Louisiana Democrat who's facing an ongoing federal corruption probe, is being granted a spot on the Homeland Security Committee, according to Democratic aides. — The appointment will be announced Friday …
Discussion: Captain's Quarters, Hot Air, Oliver Willis, Gun Toting Liberal ™ and Wizbang
Ed Morrissey / Captain's Quarters: Dollar Bill On Homeland Security?
The Gun Toting Liberal / Gun Toting Liberal ™: Two Months In: "Blue" …
Lorie Byrd / Wizbang: MR. COLD CASH TO GET HOMELAND SECURITY SEAT?
Amanda Marcotte / Salon:
Why I had to quit the John Edwards campaign — During my brief tenure as blogmaster for a Democratic presidential contender, I experienced the right-wing smear machine firsthand — As one of the thousands, possibly millions, of bloggers out there holding forth on everything from cooking to politics …
Discussion: QandO, Althouse, Riehl World View and Pandagon
Ann Althouse / Althouse: Marcotte blames sexism for her troubles.
Amanda Marcotte / Pandagon: Article at Salon — So, the panda is red, not black and white.
OLBERMANN RE-UPS WITH MSNBC—CONF CALL AT NOON TODAY — Olbermann Named Managing Editor of "Countdown" And Will Contribute To NBC Network News Programming — "Countdown" Up an Amazing 89% Over 2006 — Media Conference Call at NOON TODAY (ET) — Dial (866) 332-6117 Conference ID #9265852 to participate
Discussion: The News Blog
Steve / The News Blog: The rise of Olbermann
TRex / Firedoglake:
Late Nite FDL: Death Threats from Malkin Readers (And Other …
Late Nite FDL: Death Threats from Malkin Readers (And Other …
Discussion: RADAR
David Bromwich / eurekalert.org:
Antarctic temperatures disagree with climate model predictions — COLUMBUS , Ohio - A new report on climate over the world's southernmost continent shows that temperatures during the late 20th century did not climb as had been predicted by many global climate models.
Discussion: Flopping Aces, The Strata-Sphere and small dead animals
AJStrata / The Strata-Sphere: More Bad Science On Global Warming
Greg Simmons / Fox News:
CONGRESSMAN MURTHA CRAFTS BILL TO PREVENT IRAQ TROOP DEPLOYMENTS — WASHINGTON — A powerful Democrat and Iraq war foe said he intends to introduce legislation in the coming weeks that would effectively end President Bush's plans to send 21,500 more troops into Iraq by setting limits on which troops can be sent.
Discussion: Taylor Marsh, Democrats.com, First Read, Gateway Pundit, Daily Pundit and Anti-Idiotarian Rottweiler
David Swanson / Democrats.com: Murtha Only Intends to Undo the Escalation
Mark Murray / First Read: MURTHA'S ANTI-SURGE PLAN
Dick Polman / Dick Polman's American Debate:
The "honorary soul brother" calls in his markers — This little item ran on the wires the other night: "Two key black political leaders in South Carolina who backed John Edwards in 2004 said Tuesday they were supporting Sen. Hillary Rodham Clinton's bid for the Democratic presidential nomination."
Discussion: The Moderate Voice and TIME
Tom Bevan / TIME: Real Clear Politics: The Worst Apology In History
David Brown / Washington Post:
One Hot Archaeological Find — Chili Peppers Spiced Up Life 6,100 Years Ago — Inhabitants of the New World had chili peppers and the makings of taco chips 6,100 years ago, according to new research that examined the bowl-scrapings of people sprinkled throughout Central America and the Amazon basin.
Steve Clemons / The Huffington Post: Evolving Beyond the Chili Pepper


text:
Sinfully Simple Fruit Cobbler
1 1/4 cups sugar
1 cup all purpose flour
1 cup whole milk or half and half
1 stick melted butter
2 cups fresh or frozen, raspberries, blackberries, blueberries, or combination
Spread berries in the bottom of an 8"x 8" seasoned cast iron skillet.
Whisk together 1 cup sugar, flour, and milk until just blended. Whisk in the melted butter. Pour batter over the berries. Sprinkle the remaining 1/4 cup sugar evenly over the batter.
Bake at 350 degrees for 1 hour or until golden brown and bubbly.
My hubby said this is the best cobbler I've ever made. I've never made one in a cast iron skillet before. I love anything that I can whip up in five minutes!
Thanks for stopping by and God bless.
But as for you, brethren,
do not grow weary in doing good.
2 Thes. 3:13
This post is linked to Tuesdays With a Twist, The Dedicated House, Between Naps on the Porch,
and Sugarbee Crafts.


text:
Welcome to my blog. I have been on Facebook much longer than I have had this blog. It had been a while since I've blogged and began missing it some. So I decided to start the blog to accommodate my page.
Here I will post all my latest book reviews. Some old books and others new. Just all depending on what my mood is for reading. I am currently not accepting arcs for review, as I want to just enjoy reading what I want and not being on a tight schedule.
I have a very open taste in genres. I read but not limited to; Contemporary Romance, NA, Paranormal, Suspense, Thrillers, and anything else that piques my interest.
As well as my latest book reviews, I'll post some cover reveals, and blog tours, just not an overwhelming amount of them.
I also started a tab for what's on my mind. On this I will post random thoughts. Some will be on the book community, others may be completely outside of that. Some of my interests include, Crossfit, healthy eating, self love, reading, and so much more. So if you do not care for what's on my mind, just don't open that tab 😉
Hope you enjoy my blog!


text:
A new solution
for an old dilemma
for an old dilemma
Our goal is to be available and for our product to be accessed by anyone, anywhere, anytime.
Monitor mood and habits
Application for individuals to monitor their mood and their habits. It will read trends and predict reactions.
Professional Application
It will be used in retail for better research over people's shopping habits or interpreting in politics.
Powerful Tool
It will be more than just a simple tool, it will be a powerful tool. The possibilities are endless.
We believe in our research and its autonomy.
We are committed to deliver excellence in mental healthcare diagnosis by focusing on each client and their needs. Learn more about us!
Our Approach
Computational strategies that complement complex subjective evaluations. Interpretation of memory reports and word connectedness.
Accuracy in schizophrenia diagnosis for both chronic and first episode patientes with a maximum of one minute of recorded speech.
Our approach represents spontaneous word trajectory as a graph, quantifying abnormal Formal Thought Disordrs (FTDs) related topology.


text:
Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration: Possible Association with Clinical Changes
Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin , a decrease in leukocytes , and an increase in platelets . We found a negative correlation between the amount of platelets and their volume (, Pearson correlation coefficient: −0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (, sensitivity of 76.9% and specificity of 80%). Conclusion. Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).
1. Introduction
Age-related macular degeneration (AMD) is the main cause of legal blindness among the elderly [1–4]. AMD usually begins as the dry form of the disease. Arresting the progression of the disease with effective treatment at this stage, when the vision is not markedly damaged, would be desirable. However, there is no proven therapy for advanced dry macular degeneration. The rheological aspects of the disease may be the key for treatment. One such therapy was described by Klingel et al. [4–7]. The methodology and clinical possibilities of rheological therapy (e.g., rheopheresis, rheohemapheresis, and hemorheopheresis) and the importance of microvascular flow were verified [4, 6]. The aim of the therapy is to stop the progression of the disease. In several cases, we observed certain improvements, such as the disappearance of the drusen or a reduction of thedrusenoid retinal pigment epithelium detachment (DPED) area [8–10].
During the course of AMD, periods of both long-term stabilization and sudden turns for the worse may occur. Therefore, recognizing the disease activity in time and stopping its progress by RHF are necessary. During our long-term research of AMD and other microcirculation disorders, we have studied markers of clinical activity and the possibilities of improving the clinical state after extracorporeal elimination. We have found changes in markers of apoptosis, several cytokines, interleukins, or endoglin [11]. Obtaining these markers is technically difficult and relatively expensive, and the results are not immediately available. However, we identified several interesting changes in the complete blood count that could serve as easily available markers of the therapy effectiveness. Determining the changes in the blood counts and understanding their relationship with clinical improvement (the DPED resorption) are the objectives of this study.
2. Materials and Methods
2.1. Patients
The 46 patients included in this study, 17 men and 29 women, suffered from the dry form of age-related macular degeneration. The mean age of the patients was 68.9 (±7.2) years, and their age range was 53–86 years. The patients had to have a diagnosis of AMD in both eyes, with dry AMD in one or both eyes, confirmed by fluorescein angiography and fundus photography. The controls were recruited from healthy blood donors: 20 men and 50 women. The mean age of the controls was years, and their age range was 19–61 years.
2.2. Rheohemapheresis
Our modification of the cascade method (named rheohemapheresis) was used for the therapy of our patients. After plasma separation (blood-cell separator, Cobe Spectra, Denver, USA), the separated plasma was pumped through a rheofilter (Evaflux 4A, Kuraray, Osaka, Japan). The size of the filter pores enabled a considerable amount of high molecular weight (HMW), rheologically active substances (such as LDL-cholesterol, lipoprotein(a), fibrinogen, 2-macroglobulin, and immunoglobulins, especially IgM) to be captured. The amount of washed plasma was calculated by the computer of the Cobe Spectra separator. In each therapeutic series, the amount washed was 1 body volume during the first procedure (for safety reasons) and 1.5 body volumes in all the following procedures. The plasma flow was continual, and anticoagulation was performed with a basic bolus of heparin and then continually with an ACD-A (Baxter, USA) solution. Every patient was treated with a series of 8 RHF procedures over 10 weeks (twice, every other day, in the first week, followed by 2 weeks rest period and repeated again 4 times). The procedures used have been previously described elsewhere [8–10].
2.3. Laboratory Examinations
Blood samples were collected before and after the first and the eighth (the last) sessions. The blood samples were measured at accredited laboratories (Faculty Hospital, Hradec Kralove, CZ) with standard methods using the Sysmex XE-2100 device (Sysmex Corporation, Kobe, Japan). Determination of the complete blood count was performed using 100 L of blood, and the response time was approximately 15 minutes after the laboratory received the sample.
2.4. DPED Evaluation
Optical coherence tomography (OCT) was performed using a Stratus OCT (OCT 3 Stratus, Zeiss, Jena, Germany) before and 2.5 years after the therapy. DPED was found in 36 eyes. The subsequent fundus photography was performed to evaluate the DPED area. The Visupac method (Visupac System, Zeiss, Jena, Germany, which measures the DPED area in ) outlined the DPED area, and a copy of this area was transferred to the studied picture with special software.
2.5. Statistics
Univariate comparisons of continuous variables within groups were performed with the paired t-test or the nonparametric Wilcoxon rank sum test in cases of nonnormally distributed variables. For independent groups, the unpaired t-test or nonparametric Mann-Whitney rank sum test was used. The association of platelet number and its volume before and after the rheopheretic series was tested using the Pearson product moment correlation. The statistical analyses were performed with SigmaPlot for Windows, version 11. The results are presented as the means (±SD). The platelet (109/L)/MPV (fL) ratio for the prediction of clinical outcome was tested with ROC (receiver operating characteristic) curve analysis. After generating the ROC curves, we evaluated the criterion value, sensitivity, specificity, and area under the curve (AUC) as a marker of the test quality (AUC: 1–0.97, excellent; 0.97–0.92, very good; 0.92–0.75, good; 0.75–0.50, applicable test). The ROC analysis was performed in MedCalc 12.4 for Windows.
3. Results
The blood count, fibrinogen, and cholesterol changes before the first and last sessions are shown in Table 1. The hemoglobin level dropped during the procedures () until 10 weeks after the therapy initiation. The leukocyte levels were raised after the first procedure but were reduced before the last session (). The comparison of the leukocyte levels before the start of apheresis revealed that the number of leukocytes was elevated in the patients compared with the healthy controls () (Table 2). The number of platelets increased during the procedures (). When searching for an association among the changes in selected parameters, we found a negative association between the difference in the platelet number and its volume (, Pearson correlation coefficient: −0.509). The platelet numbers were reduced with each procedure (median 226 versus 216 before and after each procedure) (). However, during the long-term course, the platelet quantity was increased (224 before the first procedure versus 235 before the last procedure) (). To evaluate the clinical effect (change in the size of the DPED area before and after the treatment), we used the platelet/MPV ratio. Using ROC analysis for the prediction of a favorable prognosis, we determined that the cutoff of 21.5 () had a sensitivity of 76.9%, a specificity of 80.0%, and an AUC of 0.817 (good quality) (Figure 1). Positive predictive value is 90.9% and negative predictive value is 57.1%. Patients with a platelet/MPV ratio greater than 21.5 before the last RHF had a significantly better outcome (, mean regression in the DPED area of 3.35 [±2.88] versus 0.344 [±2.63]).
4. Discussion
RHF is used for the treatment of sudden hearing loss, age-related macular degeneration, peripheral arterial disease, and several other microcirculatory diseases [6, 7, 12, 13]. Data supporting the efficacy of this procedure have been published, but detailed pathophysiological explanations of the positive clinical effects are not clear or are missing. However, several possible mechanisms have been proposed. In our previous study, we demonstrated that there is a reduction in the blood viscosity in AMD [9]. After RHF, a decrease in the macromolecule concentrations (mainly fibrinogen) occurred [14], whereas erythrocyte deformability improved [13]. Together, both led to improved blood supply in the microcirculation. Improved microcirculation could arrest the disease progression and lead to a substantial improvement in the visual function in people suffering from AMD [15, 16]. Several other factors may play important roles; for example, endothelial progenitor cells (EPC) derived from the bone marrow might mediate a long-term effect. Therapy with statins, erythropoietin, or estrogens demonstrated an increase in the circulating EPC [17]. Therapeutic apheresis was capable of mobilizing such cells [18]. Removing cytokines, inflammatory mediators, or yet-unknown plasma components might be another method to induce the long-term clinical effects of RHF. Thus, there appears to be a "pleiotropic effect" similar to that described in LDL apheresis [17].
According to the recent literature concerning AMD, significant changes in the complement system have been observed, mainly in activation of several complement components [19]. The activity changes are time-dependent. Currently, we hypothesize that RHF favorably influences several clinical changes, including vision [10], and favorably influences the pathways of complement activation and H protein regulation. Indeed, the first results showed the decreasing activity of several complement components after rheohemapheresis (data unpublished).
Our study showed immediate changes in the blood count parameters after a single apheresis treatment, and long-term changes were induced over the entire rheopheretic therapy series. The decrease in the hemoglobin level was most likely the result of a small blood loss in the device (10–30 mL, according to the manufacturer). This change is logical and was observed during the entire RHF course. This small amount of blood loss can be presumed to be replaced with increased production during the intervals between the procedures. Any differences between the hemoglobin values in the controls and patients before the therapy were not observed.
In the leukocytes, in contrast, the admission value was higher (not clinically dangerous) in patients than in healthy controls (). We did not try to search for age and sex matched healthy controls because neither of these parameters has a significant impact on leukocytes level [20]. Higher levels of leukocytes may be a negative prognostic factor of the disease, as in several other diseases. Twig et al. described a higher risk of coronary artery disease in patients with leukocytes in the upper 2 quintiles [21]. Similarly, other authors described an increased level of leukocytes as a risk factor for peripheral artery disease [22], heart failure [23], or ischemic cardiovascular disease [24]. No data from the literature have been found regarding increased leukocyte values or their importance in AMD. During the course of a single apheresis treatment, the leukocyte level increased due to the leukocyte activation caused by the contact with the microenvironment in the separator tubes or rheopheretic filter. During the 7 cycles, the leukocyte value decreased significantly, which likely corresponded with the clinical benefits of rheohemapheresis (together with the decreases in the LDL-cholesterol and fibrinogen levels).
The number of thrombocytes (and their MPV) prior to the rheopheresis in the patients was the same as in the controls. In a single procedure, the number of thrombocytes (and their MPV) is well known to decrease due to their losses in the separator tubes or the rheopheretic filter (herein, this loss is likely larger, with more active platelets being caught). However, during rheopheresis, their numbers increase. Additionally, Macher et al. described an elevation of thrombocytes in donors 14–42 days following multicomponent apheresis [25]. The generation of thrombocytes is regulated by thrombopoietin, and thrombopoietin is increasingly washed out with the decrease in platelet number [26]. Other possible factors influencing platelet generation are granulocyte-colony stimulating factors, interleukins, and nitrogen oxides [27]. These agents are increasingly released in endothelial dysfunction, typically in diabetes, brain stroke, and cardiac ischemia [28]. The volume and shape of the platelets also increase during their activation. Larger platelets contain more granules, thromboxan A2, serotonin, and ATP and express more adhesive molecules (P-selectin, GpIIb/IIIa) [29]. Increased platelet volume has been described in patients with diabetes, coronary affection, obesity, hypercholesterolemia, ictus [30, 31], and other diseases. Therefore, we believed that also evaluating the MCV in patients with AMD would be useful.
In our group of patients, the platelet volume was negatively correlated with the platelet number. Brækkan et al. described such negative dependence in a sample of 25,923 healthy participants (Pearson correlation , ) [32]. An increased number of smaller platelets appeared to be produced during thrombopoiesis activation and vice versa. With regard to the demonstrated relationship between higher MPV and changes in microcirculation or in atherosclerotic complications [30, 31], the increased number of smaller thrombocytes in AMD may be considered to be prognostically more favorable.
The long-term efficacy of the dry AMD therapy with rheohemapheresis in our group of patients was demonstrated previously [8].
To determine the changes in the DPED area, we measured the area before therapy and then 2.5 years after the therapy had been completed (see our previous study [33]). The area decreased with time compared with the controls; the increased area in the controls was significant (). Our present-day study confirmed the positive relationship of the platelet count/MPV ratio with the change in the DPED area and that the clinical result of the RHF therapy was associated with clinical improvement (higher platelet/MPV ratio after RHF therapy = regression of the DPED area). This relationship is not causal (i.e., the higher platelet count and clinical improvement are apparently a consequence caused by the activity of other factors), but it may serve as an inexpensive and easily available prognostic biomarker with sufficient sensitivity and specificity. We can presume that this marker could be the guide for the intensity (additional cycles) of the treatment. To the best of our knowledge, there are no publications with similar results. Further research is needed with more patients to verify these observations.
5. Conclusion
The basic blood count parameters significantly changed during the rheohemapheresis treatments. Although these changes are not clinically significant, they may be highly significant for research. The changes occur not only after individual RHF procedures (see above) but also during long-term followup due to changes in the microenvironment. The thrombocyte count/MPV ratio at the end of the rheohemapheresis therapy may serve as a laboratory biomarker for patient prognosis.
Conflict of Interests
The authors declare that there is no conflict of interests regarding the publication of this paper.
This work was supported by Ministry of Health, Czech Republic, nos. NT/14037, NT/13475, Prvouk P37/12, 00179906, and Grant Agency of Charles University (GAUK) 373611.
A. J. Fell, K. Engelmann, G. Richard, C. Fassbender, W. Wahls, and R. Klingel, "A systematic approach to therapy of age-related macular degeneration (AMD)?" Ophthalmologe, vol. 99, no. 10, pp. 780–784, 2002.View at: Publisher Site | Google Scholar
R. Klein, C. Chou, B. E. K. Klein, X. Zhang, S. M. Meuer, and J. B. Saaddine, "Prevalence of age-related macular degeneration in the US population," Archives of Ophthalmology, vol. 129, no. 1, pp. 75–80, 2011.View at: Publisher Site | Google Scholar
K. Michalska-Malecka, L. Slowinska, M. Dorecka, and W. Romaniuk, "Correlations in some pathogenetic factors and values of hemorheological parameters in age-related macular degeneration," Clinical Hemorheology and Microcirculation, vol. 38, no. 3, pp. 209–216, 2008.View at: Google Scholar
R. Klingel, C. Fassbender, T. Faßbender, and B. Göhlen, "Clinical studies to implement Rheopheresis for age-related macular degeneration guided by evidence-based-medicine," Transfusion and Apheresis Science, vol. 29, no. 1, pp. 71–84, 2003.View at: Publisher Site | Google Scholar
R. Klingel, B. Erdtracht, V. Gauss, A. Piazolo, P. Mausfeld-Lafdhiya, and C. Diehm, "Rheopheresis in patients with critical limb ischemia—results of an open label prospective pilot trial," Therapeutic Apheresis and Dialysis, vol. 9, no. 6, pp. 473–481, 2005.View at: Publisher Site | Google Scholar
R. Klingel, C. Fassbender, T. Fassbender, B. Erdtracht, and J. Berrouschot, "Rheopheresis: rheologic, functional, and structural aspects," Therapeutic Apheresis, vol. 4, no. 5, pp. 348–357, 2000.View at: Publisher Site | Google Scholar
R. Klingel, C. Fassbender, A. Heibges et al., "RheoNet registry analysis of rheopheresis for microcirculatory disorders with a focus on age-related macular degeneration," Therapeutic Apheresis and Dialysis, vol. 14, no. 3, pp. 276–286, 2010.View at: Publisher Site | Google Scholar
E. Rencová, M. Bláha, J. Studnicka et al., "Reduction in the drusenoid retinal pigment epithelium detachment area in the dry form of age-related macular degeneration 2. 5 years after rheohemapheresis," Acta Ophthalmologica, vol. 91, no. 5, pp. e406–e408, 2013.View at: Google Scholar
M. Bláha, E. Rencová, H. Langrova et al., "The importance of rheological parameters in the therapy of the dry form of age-related macular degeneration with rheohaemapheresis," Clinical Hemorheology and Microcirculation, vol. 50, no. 4, pp. 245–255, 2012.View at: Google Scholar
E. Rencová, M. Bláha, J. Studnička et al., "Haemorheopheresis could block the progression of the dry form of age-related macular degeneration with soft drusen to the neovascular form," Acta Ophthalmologica, vol. 89, no. 5, pp. 463–471, 2011.View at: Publisher Site | Google Scholar
M. Bláha, M. Cermanova, V. Bláha et al., "Elevated serum soluble endoglin (sCD105) decreased during extracorporeal elimination therapy for familial hypercholesterolemia," Atherosclerosis, vol. 197, no. 1, pp. 264–270, 2008.View at: Publisher Site | Google Scholar
A. Ramunni, P. Brescia, G. de Fino, G. Piscopo, and L. Gesualdo, "Therapeutic apheresis in peripheral and retinal circulatory disorders," Clinical Research in Cardiology Supplements, vol. 7, supplement 1, pp. 41–44, 2012.View at: Google Scholar
H. Borberg and M. Tauchert, "Rheohaemapheresis of ophthalmological diseases and diseases of the microcirculation," Transfusion and Apheresis Science, vol. 34, no. 1, pp. 41–49, 2006.View at: Publisher Site | Google Scholar
C. Otto, W. O. Richter, and P. Schwandt, "Contribution of fibrinogen and lipoproteins to plasma viscosity in hypercholesterolemia and hypertriglyceridemia: evaluation by selective depletion of low-density lipoproteins or fibrinogen," Metabolism, vol. 49, no. 6, pp. 810–813, 2000.View at: Google Scholar
M. J. Koss, P. Kurz, T. Tsobanelis et al., "Prospective, randomized, controlled clinical study evaluating the efficacy of Rheopheresis for dry age-related macular degeneration," Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 247, no. 10, pp. 1297–1306, 2009.View at: Publisher Site | Google Scholar
J. Yeh, C. Cheng, and H. Chiu, "A case report of double-filtration plasmapheresis for the treatment of age-related macular degeneration," Therapeutic Apheresis and Dialysis, vol. 12, no. 6, pp. 500–504, 2008.View at: Publisher Site | Google Scholar
A. Ramunni, M. Burzo, L. Vernò, and P. Brescia, "Pleiotropic effects of LDL apheresis," Atherosclerosis Supplements, vol. 10, no. 5, pp. 53–55, 2009.View at: Publisher Site | Google Scholar
A. Ramunni, P. Brescia, P. Dambra et al., "Effect of low-density lipoprotein apheresis on circulating endothelial progenitor cells in familial hypercholesterolemia," Blood Purification, vol. 29, no. 4, pp. 383–389, 2010.View at: Publisher Site | Google Scholar
R. Troutbeck, S. Al-Qureshi, and R. H. Guymer, "Therapeutic targeting of the complement system in age-related macular degeneration: a review," Clinical and Experimental Ophthalmology, vol. 40, no. 1, pp. 18–26, 2012.View at: Publisher Site | Google Scholar
U. Mahlknecht and S. Kaiser, "Age-related changes in peripheral blood counts in humans," Experimental and Therapeutic Medicine, vol. 1, no. 6, pp. 1019–1025, 2010.View at: Publisher Site | Google Scholar
G. Twig, A. Afek, A. Shamiss et al., "White blood cell count and the risk for coronary artery disease in young adults," PLoS ONE, vol. 7, no. 10, Article ID e47183, 2012.View at: Google Scholar
J. Chen, L. Lin, H. Lee et al., "Association of white blood cell count and peripheral arterial disease in patients with and without traditional risk factors," Angiology, vol. 61, no. 4, pp. 382–387, 2010.View at: Publisher Site | Google Scholar
W. Bekwelem, P. L. Lutsey, L. R. Loehr et al., "White blood cell count, C-reactive protein, and incident heart failure in the Atherosclerosis Risk in Communities (ARIC) study," Annals of Epidemiology, vol. 21, no. 10, pp. 739–748, 2011.View at: Publisher Site | Google Scholar
Q. Liu, D. Zhao, W. Wang et al., "The association between white blood cell count and 10-year cardiovascular risk in a large Chinese cohort aged 35–64 years," Zhonghua Xin Xue Guan Bing Za Zhi, vol. 36, no. 5, pp. 453–457, 2008.View at: Google Scholar
S. Macher, S. Sipurzynski-Budra, K. Rosskopf et al., "Influence of multicomponent apheresis on donors' haematological and coagulation parameters, iron storage and platelet function," Vox Sanguinis, vol. 103, no. 3, pp. 194–200, 2012.View at: Publisher Site | Google Scholar
D. J. Kuter and R. D. Rosenberg, "The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit," Blood, vol. 85, no. 10, pp. 2720–2730, 1995.View at: Google Scholar
L. Vizioli, S. Muscari, and A. Muscari, "The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases," International Journal of Clinical Practice, vol. 63, no. 10, pp. 1509–1515, 2009.View at: Publisher Site | Google Scholar
A. Muscari, G. M. Puddu, A. Cenni et al., "Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes," Thrombosis Research, vol. 123, no. 4, pp. 587–591, 2009.View at: Publisher Site | Google Scholar
P. M. W. Bath and R. J. Butterworth, "Platelet size: measurement, physiology and vascular disease," Blood Coagulation and Fibrinolysis, vol. 7, no. 2, pp. 157–161, 1996.View at: Google Scholar
S. G. Chu, R. C. Becker, P. B. Berger et al., "Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis," Journal of Thrombosis and Haemostasis, vol. 8, no. 1, pp. 148–156, 2010.View at: Publisher Site | Google Scholar
P. Bath, C. Algert, N. Chapman, and B. Neal, "Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease," Stroke, vol. 35, no. 3, pp. 622–626, 2004.View at: Publisher Site | Google Scholar
S. K. Brækkan, E. B. Mathiesen, I. NjøLstad, T. Wilsgaard, J. StøRmer, and J. B. Hansen, "Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study," Journal of Thrombosis and Haemostasis, vol. 8, no. 1, pp. 157–162, 2010.View at: Publisher Site | Google Scholar
J. StudniIka, E. Rencová, M. Bláha et al., "Long-term outcomes of rheohaemapheresis in the treatment of dry form of age-related macular degeneration," Journal of Ophthalmology, vol. 2013, Article ID 135798, 8 pages, 2013.View at: Publisher Site | Google Scholar


text:
To understand all the info above, check out our Site Facts Glossary.
Grades have no direct impact on the overall score.
The Hand Job Site is up for review today, and this site obviously features handjob content just as you'd expect. They're mostly POV in nature, and the girls tend to get a little oral at times as well (at least taking a facial or something). It's part of the Adult Doorway network of sites, which you get full access to with your membership. $20 a month gets you in the door thanks to a special discount they've setup for our users.
Fun handjob action.
The handjob thing isn't all that unique, but it provides for content a little different from the norm at least. They also stick with a POV theme as well most of the time, which is even better if you ask me. The girls seem to have doing the scenes too.
Network access included.
There are several other sites included from the Adult Doorway network of sites. Most of the sites are setup pretty similarly, so getting around will be about the same wherever you go. Themes vary a little but cover all the standard bases.
Some HD videos available.
The newer videos all come in 1080p high definition format and look a lot better than the older videos do. If all of their scenes looked this good, that would help them stand out a bit more from the crowd I'd say.
Other Good Stuff:
Site and navigation need work!
The site is just so plain to get around. It's not as big of a deal here with the smaller collection, but it's still a problem. It makes everything feel pretty dated overall, and like not much effort was put into anything. Don't expect any search or browse features.
Older quality isn't as good.
Once you get out of the HD video range, the quality definitely goes downhill quite a bit. It's kinda expected with the older scenes to have that happen, but it also just kinda fits right in with the site here that's a bit of a mixed bag all around.
Slow updates; needs growth.
The last update was around four months ago, and even before that, they were iffy at best. I don't know if the site is completely done updating, or what, but it's not good news. There are around 80 scenes up currently, which isn't awful, but they could definitely use more content overall. Without updates, I don't see a huge reason to stick around all that long.
Minor Negatives:
Just an okay collection overall, though it could be better with a little TLC.
The Hand Job Site isn't really bad, but I wouldn't call it one of their better options. The newer scenes that come in HD are decent, but there's just not enough going on here to really get excited about. Updates are extremely slow, at best (if not stopped completely already), and there's not a ton here yet to keep you busy for all that long. The site itself is rather plain as well, and won't be winning any awards. I'd call this one more of an okay network site, but not one that could stand very well on its own.
About the Content:
Downloadable exclusive scenes featuring girls giving guys handjobs, usually in POV style scenes.
Download Managers:
Yes, should work.
Channel Max: 10
Able to pause/resume.
Test Software: Speed Download
Download Speed:
Download Mgr: 6.2MB/sec.
Browser: 1.1MB/sec.
(432MB video, 50Mbps cable internet)
Exclusive Info:
Advertised: 100% exclusive.
My Opinion: Yes, it looks like they shoot all their own content here.
File Sizes (HQ):
(average size, HQ)
HD Video:
Yes, some videos.
File Type: WMV
Dimensions: 1920x1080
Bitrate: 5000kbps
Quality: Not bad overall.
Live Cams:
No free live cam shows.
Logging In:
User, pw, verification image.
Saved after closing browser.
Videos don't require pw.
Logs you into network first.
Model Appearance:
Mix of models.
Generally amateur to semi-pro.
Body types from thin to thick.
Model Info:
75+ models total.
Ages 18-35.
Other Content:
No notable extras.
Other Details:
Little to no condoms.
No music in most videos.
Pic Details:
Amateur-level photography.
Little to no airbrushing.
Pic Dimensions (HQ):
Recent = 1440 x 960
Archives = 1920 x 1080
(might be taken from video camera/vidcaps)
Streaming Player:
Large flash player.
Can jump ahead immediately.
2-4 second buffer.
Smooth playback.
Good quality.
Updates in Last 7 Days:
No updates in about four months.
Submit : Add Review | Add Comment
View All: User Reviews & Comments (1)
No Outside Reviews Found.
Outside Review dates and scores are submitted to us directly by the approved review site periodically. We have limited control over the scores displayed.


text:
(785) 261-9287
Patented Systems
Quality construction is defined by both affordability and durability. The Global Technology Building Systems provides both. With key aspects including overnight curing, repeated re-usability of molds, mobility of the system, and reduced materials and labor consumption; our technology allows you to build strong concrete buildings on time and on budget.
Global Technology Building Systems
Our mission is to provide fast and durable construction with reduced materials at an affordable cost. We achieve this by making continuous improvements to our building systems and by consistently providing quality services. We ensure safety with the finished products being fireproof, seismic and hurricane resistant and sustainable. We know that our building systems can make a huge difference in many lives around the globe.
Part of our social commitment is to improve the quality of life of people around the world and to help our clients provide affordable housing. With Global Technology Building Systems, we reduce the costs of housing projects, allowing more people to live in safe homes. Our technology allows for rapid mobilization and completion of large projects including single or multi-family housing.
Global Technology Building Systems in Hays, Kansas, is one of the leading providers of budget-friendly construction systems for all kinds of concrete structures. By offering our innovative building systems, we speed up the building construction process for residential, commercial, and industrial clients. We provide engineering, drawings, and on-site technical training for our projects along with our molds, equipment, and supplies.
Our company consistently makes improvements to our building technology to help build communities around the globe. With more than 40 years of providing modular concrete construction systems, we offer consistent quality and affordability every time.
Learn about Global Technology Building Systems
Thank you for your interest. For questions or comments, please use the information listed here. We look forward to hearing from you soon.
Inquiry requires a minimum of 50+ units or large commercial projects.
Phone Number(785) 261-9287(785) 625-3486
WhatsApp Number(785) 635-2952
Address205 East 7th Street, Suite 100, Hays, KS
Service AreaProudly Providing Services Globally


text:
Generator installation services and commissioning from a team of experts. A leading generator commissioning and installation service that powers your business, undertaken by our expert team of engineers.
In a typical year, our experienced team install over 3MW of generator power. We only select market-leading products, keeping performance and energy efficiency front of mind. Our wide range of generators are supplied to clients across Europe, installed in businesses within the public sector, retail, industrial and more.
We understand that preparation is vital for a smooth installation process, so our engineers will work closely with you to ensure as little disruption to your day-to-day activities as possible. We will undertake all electrical works during the installation process, as well as providing training to the user so the generator can be operated properly.


text:
Daily Horoscope
Click here for Georgia Nicols' Daily Horoscopes
Moon Alert
There are no restrictions to shopping or important decisions today. The Moon is in Capricorn.
Aries (March 21-April 19)
You have lots of mental energy today, which is why you will attack any job that you do with intensity and purpose. In particular, you will roll up your sleeves and dig in, in a hands-on way. Conversations with work colleagues will be lively!
Taurus (April 20-May 20)
This can be a creative day because your thoughts are spinning and full of clever, creative ideas. Meanwhile, parents might come on a bit too strong with their kids today because there is so much mental energy. Think before you speak. Don't get your belly in a rash.
Gemini (May 21-June 20)
Today you have the energy to tackle home repairs. Family discussions will be intense and lively. Actually, there is so much intellectual energy at play, an argument could break out because everyone has their own idea about what's best. It was ever thus.
Cancer (June 21-July 22)
This is a busy day! Errands, short trips, appointments and discussions with siblings, relatives and neighbours will keep you hopping! You will also have strong opinions about practically everything and expect others to agree with you. (This ain't gonna happen.)
Leo (July 23-Aug. 22)
When it comes to financial issues, earnings or possibly buying something today, you have strong opinions! You are not open to hearing input from others because your mind is made up. In fact, you want others to listen to what you have to say and to your way of doing things. Oh yeah.
Virgo (Aug. 23-Sept. 22)
Today fiery Mars is lined up with your ruler Mercury, which makes your mental process excited and energetic. Your mind will be fast thinking and very active! However, it will also be all too easy to identify with your ego today and only see things your way. (Oops.)
Libra (Sept. 23-Oct. 22)
Today you have lots of energy to do research and dig deep for answers or solutions to old problems. You'll be like a dog with a bone and you won't stop until you find what you're looking for. In this way, this can be a very efficient day for you. Keep looking.
Scorpio (Oct. 23-Nov. 21)
You might find yourself at odds with a friend or a member of a group (especially someone younger) because you have such strong opinions today! Your mind is going a mile a minute, which means it's difficult to take a moment to see someone else's point of view. (Not so good.)
Sagittarius (Nov. 22-Dec. 21)
Tread carefully when talking to parents, bosses, VIPs and the police today because people are extremely opinionated! Many people are so wound up with their ideas and opinions that they're not open to listening to others. Instead, they want everyone to listen to them! (Hmmm.)
Capricorn (Dec. 22-Jan. 19)
You can use this intense mental energy today to study and learn something because you will be extremely focused. Not only that, you will be extremely curious and eager to discover new vistas and new answers. Travel plans might be ambitious.
Aquarius (Jan. 20-Feb. 18)
You'll get a lot done if you have to wade through red-tape papers regarding inheritances, shared property, taxes, debt and such because you have lots of mental energy today! You will also have no trouble defending your own best interests if any disputes arise with someone else.
Pisces (Feb. 19-March 20)
You might attract someone to you today who is opinionated and has very definite ideas. Quite likely, they will be vocal and you'll feel the hair blowing back over your ears. (Sheesh!) Go gently to avoid arguments.
If Your Birthday Is Today
Actor Andy Samberg (1978) shares your birthday today. You are creative, idealistic and impulsive. You are also determined and sometimes bossy. You are a leader who is broad-minded and courageous. Nothing will hold you back once you decide to achieve something. You love to learn and expand your world through knowledge. This year you are working to build firmer structures in your life physically and in an abstract sense.
Birthday Horoscope Zodiac Sign Is Leo
Click here to read anyone's birthday horoscope
AUGUST 18 birthday horoscope predicts that you are a Leo who can withstand the storm. You have broad shoulders to lean on and a face that is easy on the eyes. You have a natural ability to make people feel special. And you also have the guts to stand against people who are wrong.
The August 18th Leo birthday person will live life on the edge. It is typical of you to challenge someone to a drag race or to climb the highest mountain. Sometimes, your adventures can be dangerous. Some people get a kick out of this kind of thing. Leo is one of them. It is a part of your attraction that some people have toward you.
If today August 18 is your birthday, your friends and family may think you are nuts. However, you are inspiring. You are usually someone to look up too. You have very little tolerance for superficial people and like to keep your friends close and few.
The August 18 birthday personality is an honest character. You take responsibility for what you say and do around your friends and family. Furthermore, you have the respect of those younger and would make an excellent mentor or guidance counselor for the youth. People generally tend to bond with you very easily.
According to the August 18th horoscope, these Leo born individuals are likely the leaders in professions and love. You are strong but can be vulnerable too. You live life in a dream world.
Realistically, you are super supportive. More so, you like to be pampered. Sometimes, when it comes to love, you are disappointed by the outcome. It is suggested that you discuss the rules before jumping in. "Only fools rush in."
It is not easy for someone to come to you as you may think. A person looking to commit with a Lion born on this day should mimic your intellectual ability. Being rational and trustworthy, you are often accompanied by an expanding rapport with those in charge.
It is August 18th – your birthday, and you want to be wined and dined. Simple pleasures excite the lion, and this can be seen in the bedroom. It is tastefully decorated with vibrant colors. This also helps to change the bad Karma that may be surrounding you.
You put so much of your personality, hopes and dreams into rearranging your furniture. Typically, the August 18th astrology predicts that you are overly sensitive. You tend to take things too seriously.
If you are in a relationship with a Leo born on this zodiac birthday, then you are likely to keep looking keen this lion is expected to enjoy being free as committing is hard to do.
You will make someone a dependable and loving friend but making a lasting relationship is usually last on the list of things to do. However, when the lion does decide to settle down, it will be with someone who has become your best friend.
The August 18 zodiac also shows that you will seek employment in leadership positions. You have great potential to be successful especially in areas concerning banking or financial matters, but you don't know how to say no. You tend to be creative as well and could easily be employed in this industry.
Characteristically, you have great attention to detail. Your hobby could turn into something profitable as well. You could publish that book you have been writing. There are many opportunities for you even if it meant going back to school for further training.
As per the August 18th birthday meanings, you will typically be overweight. This is mainly due to the fact you do not stick to a diet plan. You indulge in foods that are fatty and have very little nutritional value.
This could be a problem as your workouts could be in vain. You will need a little more than doing chores to have the body you want. It will take work and determination to maintain a healthy body, soul, and mind.
Those with an August 18 birthday personality are willful and emotional people. You can be super sensitive and easily upset. You tend to be knowledgeable and love to learn from life, love, and relationships.
This Leo is not typically found at the gym but has what it takes to have a healthier body. You would rather date than to commit but once you decide to commit, you are loyal and loving.
Famous People And Celebrities Born On August 18
Steve Chen, Edward Norton, Robert Redford, Christian Slater, Patrick Swayze, Malcolm Jamal Warner, Shelley Winters
See: Famous Celebrities Born On August 18
This Day That Year –August 18 In History
1926 – The first time a weather map is used
1940 – In England, 71 German planes gunned down
1958 – On the Cuban circuit radio, Fidel Castro was heard making a speech
1973 – Hank Aaron beats Stan Musial's record for extra base hits with a score of 1,378
August 18 Simha Rashi (Vedic Moon Sign)
August 18 Chinese Zodiac MONKEY
August 18 Birthday Planet
Your ruling planet is Sun that symbolizes our core inner self and gives us the energy to be successful.
August 18 Birthday Symbols
The Lion Is The Symbol For The Leo Sun Sign
August 18 Birthday Tarot Card
Your Birthday Tarot Card is The Moon. This card symbolizes your imagination, fears, and illusions. The Minor Arcana cards are Seven of Wands and King of Pentacles
August 18 Birthday Zodiac Compatibility
You are most compatible with people born under Zodiac Sign Aquarius: This can be a happy and entertaining match.
You are not compatible with people born under Zodiac Sign Virgo: This relationship will be one with divided opinions.
See Also:
August 18 Lucky Numbers
Number 9 – This number represents universal love, wisdom, communication, and intuition.
Number 8 – This number signifies your materialistic personality and how you perceive Karma.
Read about: Birthday Numerology
Lucky Colors For August 18th Birthday
Red: This color stands for positive energy, vitality, love, and strength of character.
Gold: This is a color that represents success, knowledge, abundance, and prestige.
Lucky Days For August 18 Birthday
Sunday – This is the day of Sun that signifies how you inspire and plan your future.
Tuesday – The day of planet Mars that stands for your strong ability to overcome obstacles and move ahead.
August 18 Birthstone Ruby
Your lucky gemstone is Ruby which symbolizes intensity, stimulation, focus, integrity and wealth.
Ideal Zodiac Birthday Gifts For People Born On August 18th
A pretty silk tie with prints for the man and an engraved travel kit bag for the woman. The August 18 birthday zodiac predicts that you love things that are delicate and elegant.
Moon Goddess' Current Phase
From Moongiant.com – You can use this link to go forward or backward in time for Moon phase information. If you are curious you can even find out what phase the Moon was in when you or anyone else, you know was on the date the person was born.
The Moon's current phase for today and tonight is a Waxing Gibbous phase. This phase is when the moon is more than 50% illuminated but not yet a Full Moon. The phase lasts about 7 days with the moon becoming more illuminated each day until the Full Moon. During a Waxing Gibbous the moon rises in the east in mid-afternoon and is high in the eastern sky at sunset. The moon is then visible through most of the night sky setting a few hours before sunrise. The word Gibbous first appeared in the 14th century and has its roots in the Latin word "gibbosus" meaning humpbacked.
Visit the August 2021 Moon Phases Calendar to see all the daily moon phase for this month.
Today's Waxing Gibbous Phase
The Waxing Gibbous on August 18 has an illumination of 81%. This is the percentage of the Moon illuminated by the Sun. The illumination is constantly changing and can vary up to 10% a day. On August 18 the Moon is 10.49 days old. This refers to how many days it has been since the last New Moon. It takes 29.53 days for the Moon to orbit the Earth and go through the lunar cycle of all 8 Moon phases.
The 8 Lunar Phases
There are 8 lunar phases the Moon goes through in its 29.53 days lunar cycle. The 4 major Moon phases are Full Moon, New Moon, First Quarter and Last Quarter. Between these major phases, there are 4 minor ones: the Waxing Crescent, Waxing Gibbous, Waning Gibbous and Waning Crescent. For more info on the Moon Cycle and on each phase check out Wikipedia Lunar Phase page.
Custom Planetary Positions
If you need to calculate the planetary positions for a specific use and time, click on this link Currentplanetarypositions.com To figure out GMT (Greenwich Mean Time) to your local time use this link For Your Local Time and Date
Northern Hemisphere
The time for the Custom Planetary Positions is from the local time in Chicago, Illinois, United States of America
August 18, 2021
08:00 pm GMT 3:00 PM CDT
Zodiac: Tropical (Standard Western)
Moon:08 Capricorn 18
Mercury:12 Virgo 17
Venus:03 Libra 08
Mars:12 Virgo 36
Jupiter:27 Aquarius 23 Rx
Saturn:08 Aquarius 59 Rx
Uranus:14 Taurus 48
Neptune:22 Pisces 29 Rx
Pluto:24 Capricorn 50 Rx
True Lunar Node:07 Gemini 32 Rx
Mean Lunar Node:06 Gemini 41 Rx
Lilith (Black Moon):03 Gemini 29
Chiron:12 Aries 27 Rx
Ceres:05 Gemini 03
Pallas:24 Pisces 08 Rx
Juno:09 Sagittarius 01
Vesta:13 Libra 47
Eris:24 Aries 43 Rx
Southern Hemisphere
The time for the Custom Planetary Positions is from the local time in Melbourne, Victoria, Australia
19 August 2021
05:00 am GMT 3:00 PM AEST
Zodiac: Tropical (Standard Western)
Moon:13 Capricorn 38
Mercury:12 Virgo 55
Venus:03 Libra 34
Mars:12 Virgo 51
Jupiter:27 Aquarius 20 Rx
Saturn:08 Aquarius 57 Rx
Uranus:14 Taurus 48
Neptune:22 Pisces 29 Rx
Pluto:24 Capricorn 50 Rx
True Lunar Node:07 Gemini 30 Rx
Mean Lunar Node:06 Gemini 40 Rx
Lilith (Black Moon):03 Gemini 32
Chiron:12 Aries 26 Rx
Ceres:05 Gemini 09
Pallas:24 Pisces 04 Rx
Juno:09 Sagittarius 03
Eris:24 Aries 43 Rx
Witchcraft/Magickal- Wednesday
From Spells 8 for more Wednesday correspondences
Magick Candle
Light a purple candle to promote spiritual development and an enhanced consciousness. Meditating with a purple candle stimulates instrospection, change and manifestations.
Ruling Deities 🙏
Agate, Amber, Aventurine, Clear Quartz, Emerald, Moldavite.
Carrying these gemstones today can bring success and fulfillment of your goals. Wear them as a talisman or simply keep them close to you to harness their energy.
A Potion
Drink a cup of Lavender Tea today and harness the calming effects of its soothing aroma. This herbal potion can bring total relaxation of the mind and body, neutralizing any bad moods. Lavender helps reduce stress levels and sleep disorders, granting an undisturbed night of sleep and a refreshed feeling in the morning¹.


text:
Client Name:
Design #:
This unique exhibit design features a large fabric archway / banner structure that broadcasts your brand across the show floor. Interspersed throughout the exhibit, multimedia stations engage visitors with your branded message.
Additional Options:
Request A Quote
View My Gallery
fill out the form below and this design will be sent to your email address
Fill out the form below and an exhibit professional will be in contact with you.
Please fill in any additional questions you have.


text:
Nevada Court Reporters
Dear NVCRA member,
We'd love to see you for BRUNCH!
Your Activities Planning Committee has planned a brunch and you're invited. This is a great opportunity to meet NV reporters that are new to the area, do some networking, voice your opinions, or just enjoy the camaraderie of like-minded individuals.
This event is open to members, non-members, and guests.
Please RSVP to email@example.com by Sept. 12.
Saturday, September 21, 2019 at 1:00 pm
Brio Tuscan Grill - Town Square
*This is not a sponsored event. Everyone will be responsible for their own bill.