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0141 353 3057 or 07896 246 503
Having developed soreness in my right elbow which was causing problems with gripping things, I realised that I was suffering from Tennis Elbow. This condition can make your life a misery as it inhibits a number of everyday actions and causes significant pain. Even pulling a plug out of a socket or tightening a lid on a jar had become very painful. Playing my piano also didn't help.
I thought it is strange that I would get this condition as I don't play tennis. A fanatical swimmer, yes. Racquet sports, no. Golfers also get a similar condition – called, of course, 'Golfers' Elbow'. Confirmation by the GP that it was Tennis Elbow and a recommendation that physiotherapy would certainly improve and possibly cure the condition meant a trip to see Gal. The improvement over a number of weeks has been startling.
Manipulation, strengthening exercises and Ultra-Sound have all contributed to a significant advance in mobility and reduction in pain. The alternative is a steroid injection and worse than that, surgery – two options both best avoided where possible.
Gal brings a wealth of expertise to his treatment clearly explaining the path to recovery and just how physiotherapy helps. As a clinician, he is a great example of a caring medical professional with a vast understanding of his specialism who is passionate about getting you back to full fitness again.
Re-assess your need for operation.
A potential resolution to your problem without surgery or cortisone injection.
Trainers (personal/team)
If you would like GK Physiotherapy to help you, click below to get in touch.


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While some driving instructors are already filming driving lessons, there have been recent calls for this to become the legal standard. Cameras in cars would encourage responsible and safe behaviour from both parties, and provide evidence if disputes arise between learners and instructors.Continue reading Should Driving Lessons Be Filmed?
How to Calculate NI
Phone 0843 596 4157 if you need help to calculate how much National Insurance you should be paying for each tax year.
NI (National Insurance) is a type of financial contribution which most workers must pay if they are earning above a certain amount. Your NI contributions help you to qualify for state benefits, including the State Pension. This is why it is important to make sure that you are paying enough in National Insurance contributions. Read the guide below to find out how you can check if you are paying the right amount of NI.Continue reading How to Calculate NI
How to Claim Car Tax Back
Call the DVLA on 0843 178 3378 to claim road tax refunds on Vehicle Excise Duty.
You can get a refund for any full month of tax that you already paid for if you have to cancel the road tax for your vehicle. This could be due to a variety of reasons, but you need to notify the DVLA. They will cancel the vehicle tax automatically if you provide a valid reason for cancellation. Read this guide to find out how to claim car tax back and get the refund.Continue reading How to Claim Car Tax Back
How to Apply for ESA
Call the ESA helpline on 0843 596 3686 if you're eligible to apply for Employment Support Allowance and unable to work.
ESA, or Employment Support Allowance, is a government benefit to help people who are not able to work due to illness or disability. Or if they do want to work, ESA can help them with getting work if they are able to. If you are eligible for the new benefit Universal Credit, then you might not be able to claim ESA. You can apply for ESA whether you are working or not. This is a guide on how to apply for Employment Support Allowance.Continue reading How to Apply for ESA
How to Get a Budgeting Loan
Call the Social Fund on 0843 178 4097 to learn how to apply for a Budgeting Loan.
Crisis Loans are no longer available from the government, but there are still plenty of options for emergency financial support. If you have been on certain benefits for six months, then you could apply for a Budgeting Loan. You will have to pay it back, but the loan can help with immediate living costs. Read this new guide to find out how to get a Budgeting Loan.Continue reading How to Get a Budgeting Loan

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text: The importance of webpages for business communication The importance of webpages for business communication Nikolina Bregović / Thursday, May 28, 2015 0 7265 Article rating: 4.9 Nowadays, the art of communication is an inevitable part of each person's life. Every morning when you have a cup of coffee or tea with your family members, when you go to work and meet your colleagues, go to a supermarket, meet your friends, every, and I really mean every part of your life is filled with communication and it is up to you how will you present it. It is divided to verbal and non-verbal forms so you have to watch out and think about the ways of communication even if you are not using words, because you are still communicating – with your actions. Read more


text: Faculty of Graduate Studies Online Theses http://hdl.handle.net/10222/10559 2019-04-21T06:05:27Z DEVELOPING NATURAL KILLER T CELL BASED TOOLS AND STRATEGIES FOR TARGETING BREAST CANCER http://hdl.handle.net/10222/75467 DEVELOPING NATURAL KILLER T CELL BASED TOOLS AND STRATEGIES FOR TARGETING BREAST CANCER Gebremeskel, Simon Natural killer T cells are a rare population of immune-regulatory lymphocytes which have been implicated in tumor control. However, the benefit of NKT cell activation therapy in metastatic breast cancer remains poorly understood. The major focus of this work was to examine the potential role of NKT cell activation in a murine model of post-surgical breast cancer metastasis. Following surgical resection of orthotopic 4T1 mammary carcinoma tumors, BALB/c mice were treated with α-GalCer-loaded dendritic cells. This therapeutic approach decreased tumor burden, prolonged survival, and decreased the frequency and activity of myeloid derived suppressor cells. However, survival was not enhanced by additional dendritic cell treatments. This led us to investigate whether we could augment therapeutic outcomes by combining NKT cell activation with chemotherapy or oncolytic virus therapy, both capable of inducing immunogenic cell death. Combining cyclophosphamide or gemcitabine with NKT cell activation therapy significantly enhanced survival, with surviving mice exhibiting attenuated tumor growth following a second tumor challenge. Similarly, combining NKT cell activation therapy with oncolytic vesicular stomatitis virus also significantly enhanced therapeutic outcomes. Collectively, our findings demonstrate that NKT cell activation therapy as a monotherapy, or in combination with chemo- or viro-therapy, can protect mice from post-surgical breast cancer metastasis. Interpretation of Aerosol Mass Scattering Efficiency over North America Using Ground Based Measurements from the IMPROVE Network http://hdl.handle.net/10222/75465 Interpretation of Aerosol Mass Scattering Efficiency over North America Using Ground Based Measurements from the IMPROVE Network Latimer, Robyn Aerosol mass scattering efficiency affects climate forcing calculations, atmospheric visibility, and the interpretation of satellite observations of aerosol optical depth. We evaluated the representation of aerosol mass scattering efficiency in the GEOS-Chem chemical transport model over North America using collocated measurements of aerosol scatter and mass from IMPROVE network sites between 2000-2015. We found a positive bias in mass scattering efficiency given current assumptions of aerosol size distributions and particle hygroscopicity in the model. We found that overestimation of mass scattering efficiency was most significant in dry (RH<35%) and midrange humidity (35%<RH<65%) conditions, with biases of 87% and 38%, respectively. To address these biases, we investigated assumptions surrounding the two largest contributors to fine aerosol mass, organic and secondary inorganic aerosols. Inhibiting hygroscopic growth of SIA below 35% RH and decreasing the dry geometric mean radius (rg), from 0.069 um for SIA and 0.073 um for OA to 0.058 um for both aerosol types, significantly decreased the bias observed in dry conditions from 87% to 13%. Implementation of a widely used alternative representation of hygroscopic growth following k-Kohler theory for secondary inorganic (k=0.58) and organic aerosols (k=0.10) eliminated the overall bias in mass scattering efficiency. Simulated average sp over North America increased by 12%, with larger increases of 20-40% in Northern regions with high RH and hygroscopic aerosol fractions, and decreases in mass scattering efficiency up to 15% in southwestern U.S. where dust fractions are high and RH is low. Expanded insight into processing and isoform dependent properties of apelin http://hdl.handle.net/10222/75464 Expanded insight into processing and isoform dependent properties of apelin Shin, Kyungsoo Apelin is one of two peptide ligands for a class A G-protein-coupled receptor (the apelin receptor; AR/APJ). Apelin-AR signalling regulates many body systems, including the cardiovascular system, central nervous system, and adipoinsular axis. Notably, apelin can exist as various isoforms and demonstrates isoform-dependent variation in its potency and efficacy, with potency inversely correlated to isoform size. Thus, apelin processing may have an important regulatory role. The existing processing theory suggested that upon N-terminal signal peptide removal, the resulting 55-residue peptide would be an inactive proprotein (apelin-55), requiring an N-terminal truncation to a 36-residue isoform (apelin-36) for activation. Apelin-36 could then be further processed into 17- or 13-residue isoforms to increase potency. However, apelin-55 detection extracellularly did not fit this theory. Thus, I focused on better elucidating our understanding of apelin processing and the potential involvement of biological membranes in regulating the apelinergic system. I begin by demonstrating, through development of an in vitro assay using high performance liquid chromatography and mass spectrometry, that proprotein convertase subtilisin kexin subtype 3 (PCSK3) processes apelin-55 into apelin-13 specifically and preferentially, while PCSK1 and 7 could not process it. This showed that apelin-55 need not be initially processed to apelin-36. Secondly, I demonstrate that apelin processing can occur extracellularly. Specifically, the introduction of apelin-55 into the culture media of various cell lines resulted in observable changes in the level of apelin-55 with distinct processing patterns observable for different cell lines. Next, I examine apelin-55 biophysics. Through solution-state NMR spectroscopy, I provided clear demonstration that apelin-55 shows behaviour fully consistent with it being the longest bioactive isoform, rather than an inactive proprotein, correlating directly to our functional assays. I also examined interactions of both apelin-55 and -36 with zwitterionic and anionic micelles. Strikingly, both apelin isoforms preferentially interacted with anionic micelles and adopted a similar micelle-bound conformation independent of micelle headgroup. In combination, my studies have expanded the current understanding of the apelin processing pathway, increased the number of bioactive apelin isoforms, and demonstrated highly similar behaviour for all apelin isoforms. These factors have likely relevance to the apelinergic system function and regulation. The impact of long term testosterone withdrawal on cardiac excitation-contraction coupling in the mouse http://hdl.handle.net/10222/75463 The impact of long term testosterone withdrawal on cardiac excitation-contraction coupling in the mouse Ayaz, Mohammad Omar The impact of chronic testosterone withdrawal on the structure and function of the heart was investigated in male C57BL/6 mice following bilateral gonadectomy (GDX) or a sham-operation at 4 weeks of age. In vivo echocardiography showed few changes, although hearts were smaller and relaxation was slowed in GDX compared to sham controls. Peak contractions and Ca2+ transients were similar in sham and GDX field-stimulated ventricular myocytes, although both were prolonged in GDX cells. However, when the duration of depolarization was controlled by voltage clamp, GDX suppressed peak contractions and Ca2+ transients. Underlying cellular mechanisms were investigated by examining cardiac excitation-contraction coupling mechanisms. Peak Ca2+ current was smaller and Ca2+ current decay was prolonged in GDX myocytes, but there was no effect on net Ca2+ flux across the sarcolemma. This change in L-channel function was not due to effects of GDX on the underlying protein (e.g. Cav1.2) expression. Both the sarcoplasmic reticulum (SR) Ca2+ content and fractional Ca2+ release from the SR were reduced by GDX. GDX had no effect on the expression of the major cardiac SR Ca2+ release channel isoform (e.g. RyR2). However, spontaneous Ca2+ sparks, which represent fundamental Ca2+ release units from the SR, were smaller, less frequent and decayed more slowly in GDX myocytes. There was no change in expression of the cardiac sarco/endoplasmic reticulum Ca2+-ATPase (e.g. SERCA2), however, the expression of its endogenous inhibitor, phospholamban, was increased by GDX. Microelectrode studies showed that action potential duration (APD) was prolonged in GDX cells compared to sham controls. This was not due to effects on K+ channel expression (e.g. Kv1.5), but possibly due to the prolonged Ca2+ current decay, which would be expected to prolong repolarization. These longer action potentials disrupted electrical activity in the myocytes by increasing the number of early afterdepolarizations and spontaneous contractions. These findings suggest that GDX disrupts Ca2+ handling and may promote diastolic dysfunction and fatal arrhythmias, such as "torsade de pointes", in older men with low testosterone.


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So, tonight Mike makes a fabulous Beef stir fry with rice noodles in peanut thai sauce for us while I am out walking the dog in the twenty degree weather. (I volunteered myself for this as I didn't want to make dinner :) We have a delicious dinner filled with each of our own recap of the day. I finish my dinner before Mike come back to the table to sit down while he finishes his food. I notice our dog Kaiser has been sitting a good foot from Mike begging for some thai food.
It is at this moment Mike looks at Kaiser and says "Sorry you do not get any of this Asian food your German" "I'll give you a brought worst next time we have them" I then lose myself in laughter. Mike turns to me and says "I love making you laugh even if it is not that funny" I think this comment is hilarious and love my husband for every time he makes me smile, giggle, and enjoy life. He is my forever.
Tuesday, December 14, 2010
Sweet Laughter...
Posted by Erin Horn at 6:21 PM
1 comment:
- debrajo said...
Mike is a keeper! I'm so glad that you two have each other. Make every day a fun day...I'll bet that Mike thinks you're just as hilarious, though. Who in their right mind wants to take a walk in 20 degree weather just to avoid making dinner? Wow. He was the one laughing as you left, I'm sure. : )
- December 18, 2010 at 2:05 AM
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