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|[nil edit]Black Receiver 15px
|Kuroi Jushinki
|English anime
|Chakra Receivers
|English games
|Black Needle (黒針, Kokushin)
|Alternative names
|Black Rod (黒い棒, Kuroibō), Stake (杭, Kui), Transmitter (発信機, Hasshinki)
|Chapter #327
|Naruto Shippūden Episode #80
|Road to Ninja: Naruto the Movie
|Naruto Shippūden: Ultimate Ninja Heroes 3
|Naruto x UT
|Appears in
|Anime, Manga, Game, Movie
|Kekkei Genkai, Ninjutsu, Dōjutsu
|Hand seals
Black Receivers, created and used by those who possess the Rinnegan,[1] act as high-frequency chakra demodulators, allowing users to transmit their chakra into these receivers, and by extension, into those whom the receivers have been embedded in.[2] Chakra can be transmitted across vast distances, though for best results the user should be nearby and at a high elevation.[3] Black receivers disintegrate if their creator is killed or incapacitated.[4][5]
The exact source of the black receivers is unclear, having been seen produced through various means:
- Rinnegan wielders are able to generate them from their own bodies, usually their hands.[6]
- Nagato's Six Paths of Pain can also generate them from their bodies.[7]
- Madara Uchiha produced a black receiver from Hashirama's artificial body, calling it his will in physical form and telling Obito Uchiha to use it with the Six Paths Technique.[8]
- Black receivers have protruded from the Demonic Statue of the Outer Path's midsection at times,[9] on one occasion piercing Nagato's back and draining his life force.[10] He was afterwards able to control the Demonic Statue.[11]
- Black receivers have sprouted from Obito's prosthetic limb on several occasions,[12] typically while his actions are being controlled by others.[13][14]
- When Obito was the Ten-Tails' jinchūriki, he seemingly converted one of his Truth-Seeking Balls into six black receivers in order to perform the Six Red Yang Formation.[15]
Users can produce black receivers in various shapes and sizes to fit the situation.[16] The most frequently seen usage has been as part of the Six Paths of Pain, where the user embeds up to six corpses with chakra receivers, which can optionally be fashioned into body piercings, in order to reanimate and take full control of them. The user is then able to perform jutsu through the bodies and shares their field of vision.[17] Creatures summoned through the Animal Path also have these body piercings, suggesting a similar manner of control. The receivers implanted in Obito's Six Paths of Pain doubled as a means of temporarily binding the chakra of the tailed beasts sealed in the Demonic Statue to the bodies, granting them the abilities of a jinchūriki.[18]
Black receivers can be employed offensively, wielded from the hands similar to swords. By stabbing a target with these receivers the user can transmit their chakra into them, hindering their movements if pierced with only one receiver,[16] and completely paralysing them if pierced with multiple.[19] Simple contact with the receivers can apparently incur the same debilitations, an effect only other Rinnegan users are immune to.[20] If the user is able to create a strong enough transmission into a target, they can potentially control the target's movements, though it is possible for the target to resist this effect provided their own chakra is powerful enough.[21]
Offensively employing receivers through the Six Paths of Pain carries a risk to the user, as sensor types can trace the transferred chakra back to the user when pierced with one.[22] In an effect similar to that of the Truth-Seeking Balls, black receivers appear to cause permanent damage to reincarnated individuals, with their bodies being unable to repair the damage until the receivers are removed.[23][24] Obito is shown employing black receivers fashioned into giant stakes as projectiles, ejecting them from Kamui's dimension to pierce and pin targets.[25] He can then transmit chakra chains into the receivers to further strengthen the binding.[26]
- When Obito's Six Paths of Pain enter Tailed Beast Mode, the black receivers relocate from the jinchūriki's chest to the tailed beast's neck.[27]
- In Naruto Shippūden: Shinobi Rumble, Pain's Black Needle Stab temporarily reverses the controls of those stabbed with black receivers.
- Naruto Uzumaki made a similar usage to these rods when he shaped his Truth-Seeking Balls into rods and used them to immobilise Black Zetsu, preventing it from even escaping underground.
- ↑ Fourth Databook, page 255
- ↑ Naruto chapter 420, pages 15-16
- ↑ Naruto chapter 436, pages 3-4
- ↑ Naruto chapter 680, pages 10-11
- ↑ Boruto: Naruto the Movie
- ↑ Naruto chapter 647, pages 8-9
- ↑ Naruto chapter 378, page 1
- ↑ Naruto chapter 606, page 16
- ↑ Naruto chapter 512, pages 8-9
- ↑ Fourth Databook, page 247
- ↑ Naruto chapter 447, pages 8-10
- ↑ Naruto chapter 605, page 6
- ↑ Naruto chapter 637, page 2
- ↑ Naruto chapter 656, page 16
- ↑ Naruto chapter 643, page 9
- ↑ 16.0 16.1 Naruto chapter 381, pages 1-3
- ↑ Naruto chapter 565, pages 9-11
- ↑ Naruto chapter 570, page 4
- ↑ Naruto chapter 661, page 11
- ↑ Naruto chapter 673, pages 8-9
- ↑ Naruto chapter 444, pages 3-4
- ↑ Naruto chapter 441, page 14
- ↑ Naruto chapter 656, page 2
- ↑ Naruto chapter 673, page 9
- ↑ Naruto chapter 598, pages 9-10
- ↑ Naruto chapter 569, page 10
- ↑ Naruto chapter 569, pages 5-6


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I am in my 21st year of teaching, and still love every day! Being around kids keeps me young.
Yet to be added
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I received my Masters in Education in 2000
Grandmother to three wonderful grandsons....Jack, Ben, and Sam.
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Harriman Fire Department, in partnership with Harriman Utility Board, will begin flushing fire hydrants throughout the city starting today, Aug. 15.
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I usually turn to David Lebovitz and The Perfect Scoop, when I'm looking for a great ice cream recipe. He's my "ice cream guy." I especially like his fruit based ice cream recipes because they let the fruit be the star. I wanted an ice cream that would let these peaches shine. His peach ice cream sounded like a winner and didn't involve much actual cooking so no need to stand over a hot stove. That was definitely an added bonus!
Peach Ice Cream
(Printable recipe)
Source: David Lebovitz, The Perfect Scoop, adapted
4 large ripe peaches
1/2 cup water
3/4 cup sugar
1/2 cup 0% fat Greek yogurt
1 cup heavy cream
1/4 tsp vanilla extract
A few drops of freshly squeezed lemon juice.
|Beautiful ripe peaches!
|Cut into chunks
|Adding the sugar
Remove from the heat, stir in the sugar, then cool to room temperature.
Puree the cooked peaches and any liquid in a blender or food processor with the yogurt, heavy cream, vanilla, and lemon juice until almost smooth but slightly chunky.
|Turing it into ice cream!
Chill the mixture thoroughly in the refrigerator, then freeze it in your ice cream maker according to the manufacturer's instructions. If you want firmer ice cream, remove from ice cream maker and freeze for several hours or overnight.
The original recipe called for sour cream, but I had Greek yogurt on hand and substituted that for the sour cream. I think it gave the ice cream a nice tangy flavor. I also topped mine with some chopped pistachio nuts. I love the salty crunch they add to the ice cream.


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Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic Malignancy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00433745
Recruitment Status : Completed
First Posted : February 12, 2007
Results First Posted : July 8, 2014
Last Update Posted : July 8, 2014
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study will determine the safety and effectiveness of an experimental vaccine in controlling the abnormal growth of cells in patients with myelodysplastic syndrome (MDS, also known as myelodysplasia), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML). It will test whether the vaccine can increase the number of immune cells responding to the cancer and thereby slow progression of the illness, improve blood counts, reduce the need for transfusions of blood and platelets, or even achieve a disease remission. The vaccine contains part of a protein that is produced in large amounts by cells of patients with these cancers and an added substance called Montanide that helps the immune system respond to the vaccine. Sargramostim, another substances that boosts the immune response, is also given.
Patients 18 to 85 years of age with MDS, AML, ALL or CML may be eligible for this study. Candidates are screened with a medical history, physical examination, blood tests, chest x-ray and bone marrow biopsy. Women of childbearing age also have a pregnancy test.
Participants undergo the following:
- Chemotherapy entering the study.
- Leukapheresis to collect large amounts of white blood cells for infusion before vaccine administration.
- Participants may need placement of a central line (plastic tube, or catheter) in the upper part of the chest to be used for giving chemotherapy, blood or platelet transfusions, antibiotics and white blood cells, and for collecting blood samples.
- Weekly vaccine injections for nine weeks, given in the upper arm, upper leg or abdomen.
- Sargramostim injections following each vaccination.
- Standard of care treatment for MDS, AML, ALL or CML, which may include blood or platelet transfusions, growth factors, and drugs to control underlying disease and potential side effects of the vaccine.
- Weekly safety monitoring, including vital signs check, brief health assessment, blood tests and observation after the vaccination, on the day of each vaccination.
- Follow-up evaluations with blood tests and chest x-ray 3 weeks after the last vaccine dose and with blood tests and bone marrow biopsy 7 weeks after the last vaccine dose.
|Condition or disease
|Myelodysplastic Syndrome Acute Myeloid Leukemia (AML) Chronic Myeloid Leukemia (CML)
|Drug: WT1 Peptide Vaccine
|Phase 2
Leukemias and the related disorders myelodysplastic syndrome and myeloproliferative diseases represent a wide group of bone marrow stem cell malignancies. Some patients can be cured with chemotherapy or by allogeneic stem cell transplantation. However, standard treatment approaches are not effective for patients who become refractory to chemotherapy, those who relapse after transplantation and those with progressive disease. The management of such patients remains unsatisfactory and requires new treatment approaches other than chemotherapy.
The immunological graft-versus-leukemia (GVL) effect seen after allogeneic stem cell transplantation suggests that stimulating the patient's own T cell responses to hematological malignancies might also retard disease progression and even achieve disease remissions. Wilm's Tumor 1 (WT1) was identified as a target vaccine antigen because this antigen is over-expressed by cluster of differentiation 34 (CD34) plus stem cells of most patients with myeloid and lymphoid malignancies but not by normal marrow cells. A human leukocyte antigen (HLA-A0201) restricted peptide derived from the Wilm's Tumor (WT) protein is anticipated to induce T cell response against MDS and leukemic cells while sparing normal cells. Of note, about 40% of the population is HLA-A0201 positive.
Therefore we propose this Phase II trial, the second in a series of planned peptide vaccine research, which will evaluate the safety associated with an immunotherapy approach of lymphodepletion, lymphocyte infusion, and WT1 vaccination in select patients diagnosed with MDS, AML, ALL and CML. The WT1 vaccination will comprise of 9 doses of WT-1 peptide vaccines (in Montanide adjuvant) administered concomitantly with granulocyte macrophage- colony stimulating factor (GM-CSF) (Sargramostim).
The primary objectives will be to evaluate the efficacy and toxicity associated with the immunotherapy approach of lymphodepletion, lymphocyte infusion, and WT1 vaccination in selected patients with hematological malignancies.
Secondary objectives will include evaluation of disease response by following the numbers of WT1 expressing cells in blood, hematological measurements (reduction in marrow blast cells, changes in blood counts), transfusion dependence, and time to disease progression and survival.
The primary endpoint will be the side effects of treatment (toxicity and number of circulating WT1 specific T cells (efficacy ) measured through week 16 of the study (7 weeks after the last dose of vaccine).
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|4 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Wilm's Tumor 1 (WT1) Peptide Vaccination for Patients With High Risk Hematological Malignancies
|Study Start Date :
|February 2007
|Actual Primary Completion Date :
|November 2009
|Actual Study Completion Date :
|November 2009
Experimental: WT1 Peptide Vaccine
WT1 vaccination (9 doses of WT-1:126-134 peptide (in Montanide adjuvant) administered concomitantly with GM-CSF (Sargramostim)
Drug: WT1 Peptide Vaccine
WT1 vaccination (9 doses of WT-1:126-134 peptide (in Montanide adjuvant) administered concomitantly with GM-CSF (Sargramostim)
Other Name: Wilm's tumor 1 vaccine
- Cellular Immune Response [ Time Frame: 7 weeks after last dose of vaccine ]Minimum criterion for a cellular immune response was defined as the emergence of detectable T cell frequency against Willm's tumor 1 (WT1) when the pre-study analysis found no response, or a twofold increase in T cell frequency at any post vaccination time point
- Disease Response [ Time Frame: 7 weeks after last dose of vaccine ]Clinical response of underlying malignancy to the vaccination
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 85 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Diagnosed with
refractory anemia with excess of blasts (MDS-RAEB).
refractory anemia with excess of blasts in transformation (MDS-RAEBt).
secondary acute myelogenous leukemia (AML).
relapsed or refractory acute or chronic myelogenous leukemias (AML).
relapsed or refractory chronic myelogenous leukemias (CML) with accelerated phase or blast crisis
relapsed or refractory acute lymphoblastic leukemia (high risk ALL).
acute lymphoblastic leukemia (ALL) in complete remission.
chronic myelomonocytic leukemia (CMML).
Unsuitable for stem cell transplantation (age over sixty or unavailability of a fully-matched donor).
made an informed decision not to undergo the transplant procedure.
relapsed AML, CML, MDS or ALL post stem cell transplantation (SCT).
- HLA-A0201 positive.
- Ages 18 - 85 years.
- Off all lympho-ablative chemotherapeutic agents.
- All subjects (men and women) must agree to practice abstinence or effective contraception during the study period.
Inclusion Criteria Donor (for post transplant subjects without available donor lymphocyte infusion (DLI) cells):
- Related donor, HLA identical (6/6) with recipient.
- Age greater than or equal to 18 or less than or equal to 80 years old.
- Ability to comprehend the investigational nature of the study and provide informed consent.
- HIV positive (HIV-infected patients are immune-compromised and it is unlikely that these patients will be capable of mounting an immune response to the vaccine).
- Treatment with systemic corticosteroids within 7 days prior to study entry.
- Low bone marrow reserves (less than 20 percent cellularity).
- Serum creatinine greater than 2.5mg/dl or serum bilirubin greater than 4mg/dl (patients receiving fludarabine).
- Co-morbidity of such severity that it would preclude the patient's ability to tolerate protocol therapy.
- Predicted survival less than 3 months.
- Previous allergic reaction to Montanide Adjuvant.
- Pregnant or breast feeding (Pregnant and breast-feeding women are excluded from study because the effects of vaccination are not known and may pose a risk to the developing fetus. All female patients will have a urine pregnancy test, and only those that test negative will be allowed on study).
- Enrolled in another vaccine clinical trial during the study period.
- Inability to comprehend the investigational nature of the study and provide informed consent.
Exclusion Criteria-Donor (any of the following):
- Pregnant or lactating.
- Unfit to receive filgrastim (G-CSF) and undergo apheresis (abnormal blood counts, history of stroke, uncontrolled hypertension).
- HIV positive.
- Severe psychiatric illness. Mental deficiency sufficiently severe as to make compliance with the bone marrow transplant (BMT) treatment unlikely and making informed consent impossible.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00433745
|United States, Maryland
|National Cancer Institute (NCI), 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|John Barrett, MD
|National Institutes of Health- NHLBI
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Minoo Battiwalla, M.D., Principal Investigator, National Heart, Lung, and Blood Institute (NHLBI)
|ClinicalTrials.gov Identifier:
|NCT00433745 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
07-H-0091 ( Other Identifier: National Heart Lung and Blood Institute )
|First Posted:
|February 12, 2007 Key Record Dates
|Results First Posted:
|July 8, 2014
|Last Update Posted:
|July 8, 2014
|Last Verified:
|June 2014
Myelodysplastic Syndrome (MDS)
Acute Myelogenous Leukemia (AML)
Chronic Myelogenous Leukemia (CML)
Acute Lymphoblastic Leukemia (ALL)
Wilm's Tumor-1 Peptide
Myelodysplastic Syndrome
Acute Myelogenous Leukemia
Chronic Myelogenous Leukemia
Acute Lymphoblastic Leukemia
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Wilms Tumor
Myelodysplastic Syndromes
Pathologic Processes
Neoplasms by Histologic Type
Bone Marrow Diseases
Hematologic Diseases
Precancerous Conditions
Myeloproliferative Disorders
Neoplasms, Complex and Mixed
Kidney Neoplasms
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Neoplastic Syndromes, Hereditary
Kidney Diseases
Urologic Diseases
Genetic Diseases, Inborn
Immunologic Factors
Physiological Effects of Drugs


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CHARDON: A group from Virginia Tech is returning to Northeast Ohio this week to help Chardon High School students cope with the first anniversary of a cafeteria shooting that left three classmates dead.
Some Chardon High students have already formed a bond with leaders of the movement at Virginia Tech � site of a 2007 mass shooting � designed to help students move beyond tragedy by changing the way they treat each other.
The Plain Dealer reports that about a dozen of the college students have already made trips to Ohio in advance of Wednesday�s anniversary.
The college group is working with Chardon teens to mentor students in elementary and middle schools. They want helping others to be an outlet for the students to heal.


text:
Nation & World
Key fundraiser for Afghanistan's Haqqani Network gunned down in Pakistan
A top financier of the notorious Haqqani Network, a key Afghan terrorist group, was killed late Sunday in a drive-by shooting on the outskirts of Islamabad, the Pakistani capital, four years after he was detained by Pakistani authorities here for violating United Nations and U.S. Treasury Department sanctions.
Nasiruddin Haqqani apparently had been released from custody by the Pakistani authorities and was shot dead by motorcycle-borne gunmen while returning to his home in the Bhara Kahu township of Islamabad from evening prayers at a local mosque.
There was no immediate claim of responsibility for the assassination, but Pakistani security officials and Afghan militants transiting the southern Pakistani city of Karachi said they suspected the murder had been ordered by Mullah Fazlullah, who was appointed Friday to be the new head of Tehrik-i-Taliban Pakistan, commonly known as the TTP or the Pakistani Taliban. He succeeded Hakimullah Mehsud, who was killed Nov. 1 in a U.S. drone strike in the northwest Pakistani tribal area of North Waziristan.
If that turns out to be the case, it would help cement analysts' views that the death of Mehsud and the ascendency of Fazlullah to the top spot in the Pakistani Taliban eventually will lead to a split between the Pakistani Taliban and the Haqqanis, whose alliance has been showing strains for months, particularly since September when Fazlullah ordered the assassination of the army's regional commander in the Bajaur tribal area in northern Pakistan.
The killing of Maj. Gen. Sanaullah Niazi, the highest ranking officer killed since the TTP launched its insurgency in 2007, infuriated the Pakistani military, which long has had a close relationship with the Haqqani Network.
Shortly after, Afghan Taliban-allied forces launched an attack Fazlullah's base in eastern Afghanistan in what militant commanders privately described at the time as a "punitive action taken to put Fazlullah in his place."
The hit on Nasiruddin Haqqani could have been Fazlullah's retaliation for the attack on his base, said a Taliban commander from the Afghan province of Ghazni.
Haqqani's death also could hurt the Haqqani Network's ability to finance its operations in Afghanistan. Nasiruddin Haqqani was particularly effective as a fundraiser because of his connections to the ruling families of Saudi Arabia and the United Arab Emirates. His well-born Arab mother is believed to live in Sharjah, one of the United Arab Emirates that is known for its close ties with the Saudi government.
Haqqani, who operated under the nom de guerre Dr. Khan, also may have doubled as the spokesman of the Afghan Taliban, known by the pseudonym Zabihullah Mujahid, according to the Taliban commanders currently in Karachi. They spoke on condition of anonymity because they weren't authorized to talk on behalf of the Taliban, and they did not want to alert Pakistani security agencies to their presence.
The Taliban spokesman's pseudonym is likely to have been shared by several Taliban operatives, Western security analysts have said previously.
At age 41, Nasiruddin was the eldest of nine known sons, from two wives, of the Haqqani Network's ailing founder, Jalaluddin Haqqani. The group is led in all but name by Sirajuddin Haqqani, 31, Nasir's half-brother. Two other half-brothers, Mohammed Omar and Mohammed, respectively died in a July 2010 drone strike in Pakistan's North Waziristan tribal area and in fighting with U.S.-led forces in Afghanistan's Paktia province in February 2011.
There was no comment thus far from the Pakistan government, but operatives of two federal security agencies confirmed the killing and its circumstances, on the condition that they and their employers not be named.


text:
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Aug. 12, 2004
Public Invited To Address TPW Commission on Aug. 25
AUSTIN, Texas — The Texas Parks and Wildlife Commission will hold its annual public hearing Wednesday, Aug. 25, at 2 p.m. in the Commission Hearing Room here at the Austin headquarters office at 4200 Smith School Road.
The public is invited to speak on any issues related to the Texas Parks and Wildlife Department. The TPW commission is a nine-member board appointed by the governor to oversee the department.
During the previous year, TPWD has been involved in a number of significant issues affecting hunters, anglers and park users, including: license fee increases as a result of the new freshwater fishing stamp and plans for a new fish hatchery in East Texas, cormorant depredation permits, nuisance alligator problems, riverbed vehicle access prohibition, white-tailed deer management and Chronic Wasting Disease, golden alga impacts, the new state parks pass, grass carp stocking, the World Birding Center and a ban on wildlife feeding in state parks, to name a few.
Anyone wishing to comment on the above topics or any other related issue is encouraged to attend the public hearing.
Anyone can also see past and upcoming commission agendas and comment on proposed department regulations, such as the currently proposed regulations for late season migratory game birds, on the TPWD Web site Public Comment page (http://tpwd.texas.gov/involved/pubhear).
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I want help using information from books, articles and other sources
The starting point in using information from books, articles and other sources is to have a clear understanding of your purpose. That is, what do you need from the source? For example, you might need to:
- read the source to get a better understanding of the topic
- skim it to quickly find the author's general point of view
- scan it for one specific piece of information
- look for evidence to support your own point of view
- summarise and/or critique the whole article
- focus on one or two ideas only, etc.
When you have a clear idea of what you need from the source, you then need to know how to use it in your work. Usually the source material must not be used by itself in a paragraph, but should be included along with your own words and ideas. For example, it may be evidence which follows a claim you are making, it may be the source of a particular theory or model you are using, or it may be data which you need to analyse. This requires some skills and knowledge for planning the structure of your paper.
You will also need to decide how to represent the source material – usually as a paraphrase, sometimes as a quotation – and this requires good skills for reorganising ideas and facts into new words and grammatical structures. To avoid plagiarism you need not only to paraphrase or quote appropriately but also to reference appropriately, using the citation conventions which are expected in your particular assignment, department, school, faculty and/or discipline.


text:
Immigration's latest ally: Christian right
The usual suspects pushing immigration reform have a new ally in the fight this time — the religious right.
Christian conservatives, who stayed on the sidelines in 2006 or opposed reform outright, have sprung into action for the cause.
Story Continued Below
( PHOTOS: At a glance: The Senate immigration deal)
They're talking to their congregations from the pulpit. They're urging lawmakers in private meetings to support reform. And they're even calling for change publicly.
The efforts have dramatically changed the dynamics of the debate, so much so that Republicans anxious to vote yes on a deal might have the political cover to do it.
"I think it is night and day, particularly among social conservatives," Faith and Freedom Coalition's Ralph Reed told POLITICO of the support for immigration reform.
( Also on POLITICO: House GOP takes piecemeal approach on immigration)
Reed's group released a letter Tuesday that outlines broad goals for reform, like keeping families together, reforming the visa system and securing the border.
High profile leaders are also weighing in. Mathew Staver, vice president of Liberty University, the college started by former TV minister Jerry Falwell, is on board. Focus on the Family, which for years has focused on issues like opposing abortion rights and gay marriage, is supporting immigration reform for the first time in its history — even using its radio broadcast that reaches millions to push its message.
"The issues had been so demagogued for the last five or six years, it was hopeless to get seriously into this," said Tom Minnery or Focus on the Family. "It seems the time is better. The time has changed…That's why we've become more active."
Social conservatives are directly targeting GOP offices and trying to show that they can give cover to lawmakers in the South, West and Midwest, who are worried about facing retaliation at the ballot box in 2014.
"Many of the most hostile critics got beat, a fact not lost on the other House members," said Richard Land of the Southern Baptist Convention, referring to Republicans who have lost their seats since 2006. "I think there's a bigger coalition in the House for immigration reform than people think."
( Also on POLITICO: Business, labor leaders talk guest workers at White House)
While many of the groups have put together a broad framework of what they support, it's unclear if the unity will withstand what could turn into an all-out political brawl — especially on tenuous subjects like border enforcement, citizenship and including immigration rights for gays and lesbians.
But for now, many involved in the movement say it is more about raising visibility with social conservatives.
Nearly a dozen groups, including Bread for the World, Esperanza, Christian Community Development Association and the National Association of Evangelicals, have launched a 40-day "I was a stranger" campaign asking parishioners to read a bible verse dealing with immigrants each day.
"We've moved beyond the religious leadership in our country on the evangelical side to begin influencing more of the pews," said Noel Castellanos of CCDA. "We need to inform them and expose them the way we did with our pastors."


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Adam Culp (@adamculp), organizer of the South Florida PHP Users Group (SoFloPHP) where he speaks regularly, is a Zend Certified PHP 5.3 Engineer working at Zend Technologies as a Senior Professional Services Consultant. Adam is passionate about developing with PHP and enjoys helping others write good code, implement standards, refactor efficiently, and incorporate unit and functional tests into their projects. When he is not coding or contributing to various communities he can be found hiking around the United States National Parks, teaching judo, or participating in long distance. Worked on ZF2 Certification
Alexander Veremyev has been doing IT work since 1989 at the Computer center of Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences. Graduated from Saint-Petersburg State Techincal University in 1998 with a Magister degree. Alex has over ten years of technical expirence working with XML from the very begining. He has been a lead contributor at Zend Technologies since 2005. Worked on ZF1 certificaton
Andi Gutmans leads the PHP Collaboration Project and Zend product strategy, working together with both partners and the community, to build the market's leading Web development platform. Andi has been a leading contributor to PHP since 1997. Recently, Andi spearheaded the object-oriented improvements for PHP 5. He is a member of the PHP Group, the Apache Software Foundation, and on the board of the Eclipse Foundation. Additionally, he brings a rich background in enterprise software development including real-time avionics simulation software and n-tier J2EE applications. Andi holds a B.A. in Computer Science from the Technion, Israel Institute of Technology. Worked on ZF1 Certification
Andries Seutens is a PHP guru and President of Centim Consultancy. He is Zend Certified, and a member of the Zend Education Advisory Board, the group responsible for authoring the Zend Certification Exam. When Andries is not madly coding away on a cool new project, he likes to use what little free time he has volunteering with open source projects. He is also an avid cook, movie fan, and in true Belgian fashion, a connoisseur of finely crafted beer. Worked on ZF1 Certification
Ben Scholzen is a Zend Certified Engineer who has been programming since his childhood, and started with PHP in 2000. In 2008 he started contributing to the Zend Framework, developing key components including Zend_Application. He joined the Zend Framework Community Review Team in 2010. For Zend Framework 2 he contributed features such as the new routing system and the internationalization layer. Worked on ZF2 Certification
Darby Felton is currently a senior developer for Automotive Computer Services, where he engineers software solutions for the automotive dealer industry. He has worked with PHP since 2000 and as a PHP developer for Zend Technologies made core contributions to Zend Framework. Darby holds a Bachelor of Science degree in Computer Science from the University of Missouri - Columbia and is a Zend Certified Engineer (PHP 4 and 5). Worked on ZF1 C ertification.
Enrico Zimuel is a Software Engineer since 1996. He works as Senior PHP Engineer at Zend Technologies, in the Zend Framework Team. He has been a Researcher Programmer at the Informatics Institute of the University of Amsterdam and he collaborated with the Science Department of the University of Pescara (Italy). He is a frequent speaker at PHP conferences and the author of articles and books about PHP, applied cryptography and computer security. He holds a B.Sc. (Hons) in Computer Science and Economics from the University of Pescara. He is the co-founder of the PHP User Group of Torino (Italy). Worked on ZF1 & ZF2 Certification.
Evan Coury is a core contributor and long-time user of Zend Framework who is perhaps most well known in the community for authoring the all-new ZF2 module system. He is currently a professional software architect and independent consultant. In addition to consulting and his open source contributions, Evan is also the owner of Roave, a PHP and Zend Framework consulting and development company which employs some of the most talented developers in the PHP community. Worked on ZF2 Certification
Jon Whitcraft has been working with PHP for more than 8 years, but he began working with HTML in late 1995. He is currently the lead programmer for the Indianapolis Motor Speedway and the Indy Racing League where he writes and maintains the code for over 20 websites, he is also active contributer to the Zend Framework Community providing help to the other community members and also submitting patches and bug fixes. Worked on ZF1 Certification
Marco Pivetta aka Ocramius is a software developer by day, and a passionate open source software contributor, evangelist and supporter by night. He is part of the Doctrine team and an active Zend Framework 2 contributor, constantly looking for new challenges to deal with, especially when it comes to PHP. Worked on ZF2 Certification
Matthew Weier O'Phinney was a Computer Sciences refugee for many years, but returned to programming in 2000, when he was introduced to ASP, Perl and PHP, in that order. After working in a variety of positions as well as freelancing, he joined Zend in 2005 as part of their new "eBiz" team, where he implemented CMS solutions and mid-tier web services for Zend's online presence. He moved full time to the Zend Framework team in late 2007, and took over as project lead in 2009. Worked on ZF1 & ZF2 Certification.
Maurice Kherlakian, North America Services Manager for Zend Technologies, is a seasoned PHP professional. Over the past 12 years he has built and maintained several small and large scale applications. He also worked as a system administrator for both Windows and Linux platforms. Maurice is part of the Zend Professional Services team, which gives him the opportunity to travel the globe to assist Zend's consulting customers improve their experience with PHP and Zend Solutions. He specializes in PHP and Zend Framework architectural and performance audits and implementation of best practices to provide solutions for complex problems. Worked on ZF2 Certification
Michaël Gallego is a computer science engineer who co-founded the company Maestrooo (France). While he used to be passionate about C++ that gave him a strong OOP knowledge, he now dedicates exclusively to web development. He especially focuses on technical support and Zend Framework 2 development, where he is a core contributor and maintainer. Michaël also writes beautiful code for widely used Zend Framework 2 modules like DoctrineModule or SlmMail. Worked on ZF2 Certification.
Mike Willbanks works as a Sr. Web Architect Manager and has more than a decade of experience programming the web with PHP. He is an active Zend Framework contributor and serves on the community review team. Worked on ZF2 Certification.
Nico Edtinger has chosen PHP as his tool of choice since 2000 and being a freelancer, he worked as a software architect and PHP guru for various companies. He started working on the mail reading classes for Zend Framework shortly after the project went public and been shifting between being an active contributer or lurker depending on the time needed for his other projects, like communication platforms, IPTV solutions, the latest trendy stuff on the web or whatever his customers long for. Worked on ZF1 Certification.
Ralph Schindler has experiences with PHP date back to the late 1900's during the days of PHP 3. Since 2006 his contributions to ZF have touch many different components, but currently he is the primary lead on ZendDb: ZF's database abstraction component. Ralph is currently located in his native home-town, New Orleans - partaking in as much of the great food, drink and live music as one can muster. When not in front of his computer, he can be found hacking on home-owner projects, participating in his neighborhood improvement organization, or playing with his son and chocolate labrador, Belle. He is married to Jenny, his spectacular wife and a father of two sons. Worked on ZF1 & ZF2 Certification.
Rob Allen has been programming with PHP for over seven years and is a member of the Zend Framework community and is the lead author of Zend Framework in Action. He is a contributor to the Zend Framework, developing the Zend_Config component with the help of many ideas from the mailing list. Rob holds a Masters degree in Electronic Engineering from the University of Birmingham in the UK and started out writing C++ Windows applications. He now concentrates solely on web-based applications in PHP. Rob is the Technical Director of Big Room Internet concentrating on the company's content management framework and future technologies. Worked on ZF1 & ZF2 Certification.
Ryan Mauger is the Lead Developer at Lupimedia, where he is responsible for the day to day operations of the development team. Working on everything from small business to large scale enterprise applications, largely using Zend Framework. He was the technical editor for Vikram Vaswani's book "Zend Framework: A Beginners Guide" and works in the Zend Framework community as well as contributing to the framework. Worked on ZF1 & ZF2 Certification.
Slavey Karadzhov is a full time senior consultant at Zend Technologies. He is located in Stuttgart, Germany and travels the world while trying, among other things, to help people get better understanding about programming and Zend Framework in particular. Slavey Karadzhov PHP and ZF Certified Engineer and has two major university degrees: one in Software Technology from the University of Applied Science in Stuttgart, Germany, and the other in Computer Science from Sofia University, Bulgaria. Author of the popular "Learn ZF2". Worked on ZF2 Certification.
Thomas Weidner is core developer of Zend Framework. He specifically created the complete I18N core and several other usefull classes like Zend_File_Transfer. He is working as application developer and product marketing manager at Voxtronic Technology a company specialized to do speech and data recording in high security environments. Thomas has worked with PHP since 2000 and a Zend Framework contributor since 2006. He has a deep knowledge of I18N, L10N, the Windows architecture and Web technologies. Worked on ZF1 Certification


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Wednesday, February 23, 2011
The Boy in the Box
Since tomorrow is the anniversary of when the Boy in the Box was found, I thought it was appropriate to re-post this. It is still an active homicide investigation.
On February 25, 1957, the body of a young boy approximately 4 to 5 years old, was found in the Fox Chase section of Philadelphia by Philadelphia Police officer Elmer Palmer (Note: Elmer Palmer just passed away in January 2011). Police had received a call that there was something inside a J.C. Penney bassinet box that someone had thrown away.
The subsequent autopsy showed that the blond haired boy was undernourished and had been abused. The cause of death was head injuries.
For the past 50 years, investigators have been searching for this boy's identity. They thought the case would be solved quickly, but the boy was never even reported missing. Investigators have followed thousands of leads over the years. It is still an open case, now handled by Homicide Detective Tom Augustine, who first became interested in the case as a child when he saw the posters of the boy that were displayed all over Philadelphia.
The boy's murder has been featured on America's Most Wanted and 48 Hours, but most of the leads generated by these shows have failed to produce anything. One tip from an Ohio woman in 2002 seemed the most promising. The woman appears credible but investigators have so far been unable to corroborate her story. The boy's remains were even exhumed in 1998 and an independent lab was able to obtain mitochondrial DNA from a tooth, but as long as he remains unknown, there is no one to match it to.
The sad death of this boy has generated interest all over the world. There is a website dedicated to solving the case and finding his identity--America's Unknown Child. This site has the entire case history, photographs, information on witnesses, etc. It is run by volunteers whose sole purpose is for this boy to rest in peace.
It is also being investigated by the Vidocq Society, which is an organization comprised of retired detectives and others, including a forensic sculptor who has made a bust of what the boy's father probably looked like.
I think what intrigues me most about this case is the dedication of the investigators involved. Some of the retired detectives working on this case were the original officers assigned to the investigation. Many of them have worked on their own time studying evidence, looking through hospital records and interviewing witnesses. These seasoned cops remember this boy as if he belonged to them--and in a way he does. Fifty years later, they still attend memorial services at the gravesite.
How would you have this story end? Will there ever be justice for The Boy in the Box?
5 comments:
- Ramona said...
Joyce, from an academic/writer's POV, this story hold so many intriguing elements: the mystery of the boy's identity; the dedication of Elmer Palmer for so long; the purpose of the Vidocq Society. I see why you've become fascinated with it.
Plus, that child's face is haunting, isn't it?
- Joyce Tremel said...
Very haunting. Even though it's been over fifty years, I keep hoping his murder will be solved. If this was a book it would be. Unfortunately real life doesn't always work out like a mystery novel.
- Patg said...
I remember this story. So sad.
I learned of this case a few years ago. It haunts me and I can't explain why. Possibly it's that I am the mother of two boys with special needs and although they are almost grown I feel for this little guy because he was so vulnerable. The website by the investigative team seems not to have been updated in the past few years. Do you know if there is ANYTHING new? I tried to email them but the email bounced, apparently the account is no longer active. Have they given up? I hope not. There have to be answers out there, somewhere. Some one has to know the truth.
- faith said...
This story is so sad.. I'm 12 years old and live in the US. I wish I could've been around when this happened. I hope eventually this case will be solved, but I also have doubt about it. This kid had to be tortured, so bad. It really makes me feel like killing whoever did this. Really? They put him in a box? That's f***ed up. I KNOW someone out there has a clue who did this.. Whoever did this, I hope they live/ lived a miserable, horrible f***ing life. If I did this, I wouldn't have been able to live with myself.. I hope they didn't.. Sincerely, Faith. If you want to contact me, just e-mail firstname.lastname@example.com


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If you've ever wanted to learn how to code, here's your chance. Hummingbird is back with a vengeance as it unveils a new robotics kit that can teach anyone the basic of robotic engineering, even children. The kit was released on Kickstarter and has surpassed its funding goal of $30,000.
The kit is called the Hummingbird Duo and is meant to provide a progressive robotics learning experience. Users start on level one, where they build and program their own homemade robot using the Hummingbird board. At level two, users can program their robots using computer programs Scratch 2.0 or Snap! Makers can also use the very same kit to run Arduino Leondardo (which comes installed on the backside of the board) to create a standalone robot, capable of doing anything really, since it's open source and can run on Mac, Windows, or Linux.
Hummingbird won the Parents' Choice Gold Award with its original robotics kit for children in 2012. This time around, they're marketing their updated kit to all aspiring makers. Their campaign is, of course, child-focused, and schoolteachers can get supersized classroom Hummingbird Duo kits to accommodate 16 to 24 students. The design team says the kits are equally useful for elementary children, high school teens, college kids, and adults, all with a desire to take their robotics skills to the next level.
Each kit comes equipped with a different bag of tricks, but most include the Hummingbird/Arduino board itself and add-ons, like LEDs, sensors, motors, and more. Kit options start at $69 (for just the board) and increase in price up to $1,500 for the classroom kit (for early backers, of course).
Backers can expect the Hummingbird Duo to ship as early as December. Hummingbird's self-proclaimed focus is to enhance the education of robotics, engineering, electronics, and programming. With children at the center of their projects, introducing kids to the wonderful world of engineering early on can mean a serious enhancement in how we access technology. Children are by far some of the most imaginative creatures on the planet.
Along with promoting child creativity, another company is targeting the child market, but not quite on the same level as Hummingbird. Child's Own Studio encourages children to expand their minds through drawing. The drawings are then made into plush toys that they can cherish forever. Dream it. Make it. Laugh about it when you're 30. That's their motto.
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NightSky is an ambient action-puzzle game that offers a gameplay experience unlike any other cerebral challenges fill uniquely designed picturesque worlds. Each of these worlds is broken into different areas in which the player must maneuver a sphere by using realistic physics to advance.
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Smashing Pumpkins Aim for New Album in 2014, Book 2013 SXSW Gig
The Smashing Pumpkins are back at work on new music. In a new interview with Interesting People Talking Wrestling, Pumpkins mastermind Billy Corgan reveals that he's been working on a new book, plus a new album from the band.
During the interview, Corgan discloses that he had just spent six hours writing on the book and had also been working out a new song. As for when fans might expect new music, the frontman states, "We're just starting to work on a [new] album now, so I'd say sometime early next year would be reasonable." As for the book, he adds that it likely wouldn't arrive until 2014, too. He also reveals that he's been working on a reality show for Resistance Pro Wrestling.
In the meanwhile, Smashing Pumpkins continue to book dates in support of their 'Oceania' album. The latest is expected to take place at South by Southwest next week. A Smashing Pumpkins show had been rumored heavily of late, and the Sword may have ruined the surprise. The hard rocking outfit posted on Facebook that they were playing a show with the Smashing Pumpkins as a concert alert. However, that post has since been taken down, but not before Crestfallen.com grabbed a screen shot.
The show will take place at the Red Bull Pop Up Venue at 310 E. 3rd St in Austin on March 16. To hear Corgan's full interview with Interesting People Talking Wrestling, which obviously focuses on his wrestling passion, check here.


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St. Paul mission trip fundraiser
TELL CITY – St. Paul parish will sell carryout chicken dinner to benefit the St. Paul Church Mission trip for 20 youth and adults.
The dinners will be sold Sunday on the corner of 12th and Tell streets beginning at 10:30 a.m. The dinner includes grilled chicken, creek fries and green beans for $7. The mission trip participants will help homeless, elderly, children and single mothers experience a better life in Nashville, Tenn.
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January 2001
Antibiotics allow naturally resistant variants of microbes within a population to survive and reproduce. Source: Microsoft Images.
Microorganisms — bacteria, archaea, fungi, algae, viruses and protists — are often easy to overlook. For the most part (except fungal fruiting bodies seen as mushrooms) we can't see microbes. The effects of microbes we feel are usually associated with an illness. Most people know that bacteria and viruses can act as "germs" and cause disease. Because of this it seems perfectly acceptable to try to wipe all of the germs out of our environment by using antibacterial agents (found in everything from hand soap to sweat socks) and antibiotics. However, our use of antibiotics and antibacterial agents is changing the microbes in our environment, making the germs tougher to beat and eliminating some beneficial microbes.
Beneficial functions of microorganisms
Microorganisms are essential to our very existence. They are ubiquitous, found in common environments such as soil, water, and air as well as exotic locales as diverse as deep sea hydrothermal vents and soda lime lakes. In these natural environments microorganisms have very specific jobs. They are responsible for recycling nutrients in our soil and purifying our water. We also use microorganisms in constructed environments to serve our own functions.
- Nutrient Recycling. When plants and animals take up nutrients, they are not available to other living organisms. When the plants and animals die, the nutrients remain in the carcass. If the dead material, or detritus, is not broken down by microbes, those nutrients will never become available to help sustain the life of other organisms. There are a finite amount of nutrients available in the environment and we cannot simply make more. The nutrients that are trapped in detritus must be released in order for life to continue. It is the microbial population of the environment that is responsible for this nutrient recycling.
- Health. We depend on having a microbial population, called our microbiota, for our health. There are normally 10 times more microbial cells on/in a human body than human cells. The good bacteria that live on and in us protect us from the bad invaders that might come our way. Without the good bacteria, the bad ones can slip in and easily cause us problems. Our own digestion has also evolved to use bacteria for assistance, allowing us to gain nutrition from plant polysaccharides that our own enzymes will not degrade. This is one of the reasons why taking antibiotics can lead to episodes of diarrhea - we have disrupted our natural gut biota.
- Food. Microbes have been used for centuries to provide us with food. Bread is the result of a microbial fermentation of sugars to produce carbon dioxide — the bubbles that make bread rise. We owe our beer and wine to similar little yeast that convert sugars into alcohol for our consumption. Yogurt and cheese are produced by bacterial fermentation of lactose, the sugar in milk. Microbes such as phytoplankton also serve as the nutrient source that indirectly feeds all marine animals. And microbial symbioses with plants allow them to grow strong and increase productivity — sometimes they are even essential for plant survival.
- Biodegradation. Microorganisms are responsible for getting rid the waste generated by industry and households. They detoxify acid mine drainage and other toxins that we dump into the soil and water. The nutrients gained from the breakdown of these products then go to feed plants or algae, which in turn feed all animals.
- Waste Water Treatment. When we flush things down the drain or the toilet, they go to a septic system or waste water treatment plant at the end of the line. After primary mechanical treatment and aeration microbes remove organic materials from the filthy waters that flow into these systems and, eventually, water can safely be returned to the rivers and streams. The methane produced during treatment can even be used to generate heat or electricity for the operation!
- Biosynthesis. We have discovered that microorganisms are useful for making things as well. Products such as xanthan gum (a food thickener) are harvested from their bacterial producers. Most of our vitamin B12, riboflavin, and vitamin C are produced by bacterial fermentation. Approximately 70% of antibiotics currently in use are also the product of microbial fermentation.
Sources of antibiotics in the environment
In spite of all of the benefits of having a healthy microbial population, antibiotics and antibacterial agents are added to the environment at a rate of over a million pounds per week. There are several routes of entry of antimicrobial agents into the environment. Studies have shown that introduction by these routes has changed the antibiotic susceptibility of the microbes in those environments and/or changed the predominant microbes.
Sewage. The antibiotics that we take in are not all processed by our bodies. Some of them are expelled as waste and wind up in our waste water treatment plants. Of bacteria isolated from sludge remaining after wastewater treatment at one plant, 46.4% were resistant to multiple antibiotics. Sewage from hospitals and pharmaceutical plants has been shown to contribute to antibiotic resistance in treatment plants. Rivers contaminated with urban effluent and agricultural runoff have also been shown to have greater antibiotic resistant bacterial populations than areas upstream of the contamination source. Antibiotic resistance in streams is also indirectly selected for by an increase in industrial wastes containing heavy metals.
Medical waste. The dispensing of antibiotics in a medical facility inevitably leads to waste. Discharge from hospitals has been shown to cause an increase in bacterial populations resistant to certain antibiotics such as oxytetracycline.
Production. Antibiotic sales total more than $8 billion worldwide each year. That is 50 million pounds produced each year, 25 million pounds of which are prescribed for human use. Discharge of wastewater from pharmaceutical plant has been associated with an increase in the prevalence of single- and multiple-antibiotic resistance in indicator organisms.
Household products. Over 700 "antibacterial" household products have been introduced in the past five years. These include such items as sweat socks, toothpastes, kitchen plastics, cement and paints. The more common antibacterial ingredients in these formulations are triclosan, quartenary ammonium compounds, alcohol, and bleach. Microbes resistant to each of these compounds have been documented in nature and in some human pathogens. These products wind up in the sewage or landfill after being used in our households.
Sprayed on crops. About 300,000 pounds of antibiotics are used in plant production each year. They are sprayed on high-value crops such as fruit trees to prevent bacterial infections. This can select for resistant bacteria on our crops. Not all of the spray remains on the fruit. Most of the antibiotics are washed into the soil and eventually end up in the ground water.
Animal production. Antibiotics are commonly added at subtherapeutic levels to animal feeds as growth promoters. They are also added to fishery waters. About 24 million pounds of antibiotics are fed to animals every year. Due to this practice antibiotic resistance in foods has become a health concern. Bacteria such as drug resistant Salmonella typhimurium, Escherichia coli and Enterococcus have increased clinically as animal antibiotic use has risen. It is also possible that our normal gut microbiota have gained antibiotic resistance from antibiotic-exposed food animals. A popular theory is that vancomycin resistant strains of the bacterium Enterococcus (VRE), a major cause of postsurgical infections, have arisen in Europe due to the use of the antibiotic avoparcin as an animal growth promoter. At least one study, however, shows that in minced beef and pork, VRE occurs very rarely. The use of oxytetracycline in aquaculture has been shown to cause a seasonal shift in bacterial species towards Enterobacteriaceae and is associated with increased antibiotic resistance.
Mechanisms of spread of antibiotic resistance
Antibiotics do not, in themselves, cause resistance. Instead, they allow naturally resistant variants within a population to survive and reproduce while those individuals without the resistance factor die. Once in a bacterial population, antibiotic resistance can spread rapidly. Even unrelated bacteria can gain resistance from their neighbors in a phenomenon called horizontal gene transfer. Resistance to antibiotics is encoded in DNA, the genetic blueprint for life. Bacteria are able to exchange DNA, especially in the form of plasmids (small, self-replicating circles of DNA) and pass resistance very rapidly.
Conjugation. Bacteria can fuse and exchange plasmids and sometimes chromosome fragments. Increase in mobilizing plasmids has been associated with use of antibiotics in swine husbandry. These plasmids have a broad host range and are able to cross genus lines during transfer.
Transfection. Viruses can infect bacteria and fungi, passing along genes from one infected organism to the next. These genes sometimes encode resistance factors. The use of antibiotic growth promoters in animal husbandry may increase the amount of free phage in intestines and may contribute to the spread of antibiotic resistance.
Transformation. When a bacterium lyses in its environment, any other actively-growing bacteria in that vicinity can pick up its DNA. This is another mechanism of resistance spread, since plasmids (including resistance or R plasmids) are more easily used by the recipient bacterium than chromosomal material.
Microbial populations have been shown to change due to exposure to antibiotics and antibacterial agents. We are seeing a rise in antibiotic resistance all around the world. Some diseases that were previously susceptible to a variety of antibiotics now are untreatable. According to the Center for Disease Control (CDC), approximately 70 percent of infections that people get while hospitalized are now resistant to at least one antibiotic. Resistance to antibiotics is rapidly outpacing our ability to synthesize new drugs. While only a very small proportion of bacteria in our lives can potentially harm us, we are losing our arsenal to treat these rare infections.
Curbing spread of antibiotic resistance
Antibiotic resistance is inevitable. However, there are a few things that we, as consumers, can do to control the spread of antibiotic resistance.
Do not seek antibiotics for the treatment of viral infections such as the common cold, sore throat, bronchitis, or flu. Antibiotics have no effect on viral diseases. Taking antibiotics improperly simply leads to more antibiotics in the sewage and a buildup of antibiotic resistant bacteria in your microbiota.
Take the full course of antibiotics when they are prescribed. Stopping when you feel better means that some bacteria in your body were exposed to only small doses of the antibiotic and have survived. They are now resistant to small amounts of the antibiotic. The next time you get an infection they will not be so easily killed.
Avoid unnecessary antibacterial household products. We need the bacteria that surround us, and it is possible that trying to kill them is causing harm. By introducing antibacterial products into the landfills and sewage we are ensuring that only the microbes that are resistant to these products survive. Research is underway to determine if we are selecting for resistant bacterial populations causing antibacterial agents, like antibiotics, to lose their effectiveness or disrupt the effectiveness of the wastewater treatment plants or nutrient cycling in the soil. Use antibacterial hand soaps only when dealing with ill and immunocompromised individuals.
Wash your hands. The best way to stop the spread of any bacterial infection is through simple hygiene measures. Washing hands in warm soapy water for at least 20 seconds is enough to eliminate most of the potential pathogens. Also be sure to wash all fruits and vegetables well before eating them.
Microbes are an essential part of all life on earth. The addition of antibiotics and antibacterial compounds is changing the microbial populations of the soil, water, and our own microbiota. Recognizing the numerous invaluable functions of microbes should decrease the germophobia prevalent in Western societies.
© 2001, American Institute of Biological Sciences. Educators have permission to reprint articles for classroom use; other users, please contact email@example.com for reprint permission. See reprint policy.


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Co-created by Ladan and Tania Shayan, Los Angeles natives and mother/daughter duo, the Shay collection is sophisticated and investment-worthy without sacrificing any glamour. Shay jewelry is handmade using diamonds and precious gemstones set in 18-karat gold and platinum. Pieces are meant to be stacked, layered and mixed-and-matched to create a jewelry wardrobe.
The hallmarks of Shay include an edgy take on geometry, delicate designs with big impact, and a unique perspective on Victorian and Art Deco inspiration, including baguette diamonds, and diamond-encrusted chain links as well as crescent moon pendants or updated star motifs to explore your ultra-feminine side.
Any order of $100+ receives free ground shipping at YLANG23.com.
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We want you to be completely happy with your purchase, but if you are not satisfied for any reason, we offer free returns on regular-priced orders over $100 within seven days of receipt in their complete original packaging and in unworn condition. Please call us toll free at 1-866-952-6423 or email firstname.lastname@example.com for a prepaid return label that will be sent to the original email address associated with the order. Merchandise will be insured to YLANG23.com. Credit will not include original shipping charges.
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Our knowledgeable staff is happy to answer any questions about special orders and alterations to existing stock (ring sizes, necklace lengths, etc.). Timing and pricing will vary by designer.
Please email email@example.com or call 1-866-YLANG23 with your questions and requests.


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My husband ate this soup! He is not a soup lover, but he ate it and liked it! This sounds like a small thing but in our house, it's major progress. Since I've known him he won't eat 99% of soups or stews. This is also a great way to use any turkey leftovers from Thanksgiving.
This soup is extremely versatile, with the variety of garnishes that are possible. If you don't make it too spicy, kids will also like it due to the fried chip garnish. Other garnish ideas: cilantro, sliced radish, olives, sour cream. Use what you have on hand to make this an economical meal option.
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About vegetaman
Finally, a smack against copyright maximalists. Can't wait to hear them try to explain this one away and how they still "own the rights" and they were shaking people down for payments in good faith...
Quote from the article on ArsTechnica: "This is a great step forward for all music creators," said Recording Industry Association of America Chairman and CEO Cary Sherman. "Music has tremendous value, whether it was made in 1970 or 2015. We hope others take note of this important agreement and follow SiriusXM's example."
Well, that sounds like the typical slimeball MPAA/RIAA speak we've come to expect. Basically some form of: 'Just look at all the money it has made us! And look at how little we've passed on to the people that wrote it! I mean, we said it had tremendous value -- we never said that value was for the artists! Hahaha, suckers!'
Maybe we can finally stop using SSNs as a unique identifier for people, or pretend it confirms someones' identity, since every company seems to request/require/have access to people's SSNs (and then treat that access with the type of non-chalant, non-caring attitude we've come to expect in the cyber security age).
"Err, pass out the complimentary cigarettes."
"Yeah, we smoke when we shoot the bird!"
CEO (or politician) has no idea how technology works and proceeds to spread FUD? Typical day in America, sadly. :(
Fortunately this was not a problem for me, as I still haven't forgiven them for cancelling Mega Man Legends 3. And I *DO* vote with my wallet.
A time of shareware games with no micro transactions. Truly, simpler times.
Man, I miss playing Doom and Wolfenstein in the 90s...
Wait... You can literally trademark a W?
I can still get parts for my 1952 antique tractor. Parts I don't have, I can find used, or have machined. In my work in electronics, I find that anything that has been built before can be built again, even if the parts that went into it are obsolete (microprocessors, etc.). It just takes money and planning. Did they just now realize they have a parts problem? Or did they plan this as a convenient excuse and not keep parts on hand or have orders in for replacement parts in advance?
I like the "I took a picture and he asked me for ID", because in what world does that make sense? How is that even a relevant question!? Ugh. This makes me sad.
Hey now, they're just thinking proactively about their publicity rights!
Won't somebody think of the military juntas!?
Ugh, nothing is worse in the checkout lane at the store than the person who decides they're going to pay by check... Only, they just heard their total, and NOW they start looking for their checkbook. Rather than, you know, filling everything out but the total ahead of time... Or even just having it in hand ready to go! I'm the type of guy who usually shops without a cart and only has 2 or 3 items in hand that I specifically came in for, and this drives me crazy. Express lanes are the greatest myth of all time!
Wow, as a CS person, I feel bad I never knew about the Morris worm.
Or, even worse, the travesty that befell Robert Morris due to it.
I am not a person who tells people to use a specific site or anything like that. What I am prone to do is pass along links of relevant stories of interest. For me, that is usually things related to musicians and copyright expansion and software patents (as it covers my interests and hobbies of software development, making music, and reading).
As for commenting... It depends. If the story has a low post count, or is a very relevant topic to me, I will always go in and read the comments. 80% the time I post a comment, it is because I want to comment on the story. The other 20% of the time, it is because I want to comment on something somebody else has said. I usually will make it a point to post if my viewpoint is somehow contrarian to the direction that the comments are going (no need for another "me too" post, ya know?).
Oh, and if I think I have something funny or insightful to say (ie. a relevant joke pops into my head), and the topic has a low post count, I'll almost always post as well.
Whelp, now I'm sad. :-(
I think it's just collusion with the toner cartridge industry lobby! First they get you with vendor lock in to their specific cartridges, then they get the government to use tankerloads of black ink per page!
Obligatory dark money shilling!
Somehow, this whole situation reminds me of a Monty Python Sketch (paraphrased).
ISP: "But, you have a witches nose."
Customer: "They put this on me."
ISP: "No! No we didn't! Well... Yeah, we did do that. But she is still a witch!"
Just a further push into "guilty until proven innocent" territory, coupled with no oversight.
Damn, that almost sounds like a more blanket and catch all excuse than national security... Because of "inter-national security"!


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A. Thank you for asking a very important question. Other interns may have come to the same conclusion about their experiences. Before you decide how to handle the situation, evaluate your internship and decide why it was a waste of time. Then, air your views accordingly. The following tips may help you put that negative experience behind you and look forward to future internships with a positive attitude:
- Evaluating your internship: Were your expectations realistic? You may have misunderstood the scope or duties of the internship in your haste to procure one. If so, that's your problem. You could have been overqualified for the position and found the hours dragged and you were bored. If so, consider yourself more advanced in your skills than you had previously thought. Take consolation in the fact that you're ahead of the other interns. However, if the duties or internship description changed, resulting in assignments that you felt were a waste of time, then the company is at fault here. Were you given unexpected assignments that annoyed you, such as getting coffee or making copies? You were probably too polite to say no, but you've built up resentment against the company, and understandably so. But someone needs to know how you feel.
- Expressing your feelings: There is no sense in telling anyone at the company that the internship was a waste of your time because it's too late to do anything about it. Also, keep in mind that you still want a good reference letter. You do owe it to future interns to confide your disappointment to your school's career center or counselor who set up the internship for you. To be fair, explain your evaluation of why the internship was not a success. The counselor will appreciate your information, ensuring that the next intern is better suited to the position or deciding that the company is not a good internship site for the school's students. If a student asks you about your internship, stop and think about your response. If it's a student who is considering the same internship, you might want to give your honest opinion. However, if it's an idle question that will only generate gossip, then it's better to simply shrug off the inquiry.
- Looking ahead: Fortunately, most students are expecting to experience multiple internships in their academic careers. Let's hope that all your other internships will be great. You might want to spend some time on internships.com, browsing through thousands of internships, searching for the right one for you. Enter the keywords and watch all the internships come up. Then, apply for the ones that appeal to you, giving yourself plenty of options. Be choosy. And be sure to start your search months ahead of time. Also, check in with your career center at school. After your earlier negative experience, the staff will work extra hard to ensure that your next internship is a positive one.


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29 July 2008
The Year of Magical Thinking
Here summer hums busily, the trees and flowers and insects madly propagating and procreating whilst the sun is high in the sky. Vines crawl up the oak and ash trees, and the native undergrowth is as lush as a carpet. Where there was snow and ice, there is now verdant life, bubbling and vibrant. As we mere mortals swim, canoe, hike and carouse through the increasingly stultifying heat, the natural world is more aware, however, of what is to come, as the planet incrementally tilts back on its axis. Winter is never far from one's consciousness here in the best of times, and even as sweat beads form on one's forehead and upper lip, as the vine climbs upward, one casts a nervous glance behind, towards the glowering ice already passed through and that also calmly, silently, awaits its inevitable return.
Such cyclical rhythms have proved to be my dangerous siren song this past year. I have been fascinated by the riddle of the pattern, the details of the convergences and divergences. I have been living in a world of totems and miracles, of fever visions and symbolism. However, I remain unsure of the meaning of it all. For instance, the same November week my five and half year relationship ended with finality in a misbegotten telephone conversation in rush-hour traffic, a student filed a complaint against me with my Dean, and my car irrevocably broke down on the interstate in the middle of the night. Whilst waiting for the tow truck in the dark, smoking cigarette after cigarette and wiping the tears from my face, I did not then immediately think of the coincidental patterns later apparent to me. Such ironic talismans returned at the closing of the year, the last day of school, the cleaning out of the office, events matched by other vibrations, closings and voids. They seem relevant, in a morbid fashion, but are resistant to all but the most intimate analyses, outside of the colloquial observation that it has been a real shitty year.
Such patterns have haunted me, strange coincidences that brought together the narrative threads of a disastrous year: a long and difficult break-up, a fellowship year that was not what one would have hoped it would have been, a severe financial crisis that has dogged me from beginning to end (partially informed by the reduction in salary assumed by the fellowship year), an unusually trying and dark winter. The resonance of each element amplified the effect of the others, leading to crescendo points of painful introspection that at times seemed insurmountable. It would not be dramatic, I think, to describe the past year as the absolute worst of my life. What doesn't kill you makes you stronger, goes the truism, but what gets missed in such haimische dichos is the scar tissue that remains: thickening, constraining, disfiguring.
I would like to think of myself over the past year as Alice in Wonderland, in a beautiful red silken dress, having to pass through an unavoidable hedgerow maze filled with razors and grabbing hands, beasts and unseen traps. Of course, my experience was not nearly so cinematic, although almost as surreal— crying on the interstate then appearing in class with swollen raccoon eyes, often an inability to focus on details, missed appointments and strange adventures, odd conversations with strangers and acquaintances, hours spent too much inside my head, occasionally raging neurasthenia, pins and needles and exhaustion and depression and morosity. The normal dynamic unsettled by disequilibrium, vertigo, nausea. My "process," as I have been calling it, like a pet, has been a queer sort of evolution, a Darwinian experience of metaphysical proportions, with the exception being that I have felt every cell division, been highly conscious of the protrusion of flippers, the recession of wings, the closing of gills, the elongation of the spine in preparation for upright walking.
Darwin's theory, of course, was predicated on a much longer window of time. My hyperawareness of personal mitosis over the course of the last academic year, the slicing of the cell, is not something one should live within for very long. It is unhealthy to be so aware of one's own transformation into an as-yet unknown creature. Our immune systems have been designed to respond to known and unknown threats unequivocally, unthinkingly, as a tenet of survival. Most traumas are best forgotten, but the body remembers, and the apparatus of self-defense responds free of conscious will, sometimes threatening a deadly response to a mild irritant, to an echo of the past, a swollen closing of the throat, a sudden choking. All of which is to say that, in many ways, the past is prologue, both on the corporeal and existential level.
How that prologue becomes a different narrative, how we shape it to become a different narrative rather than simply a rush of anaphylaxis, has been my challenge of this year, the struggle of my process. The long half-life of trauma was apparent in my reactions to events at school, exacerbated by more intimate and fiduciary crises, the challenge to a particular vision I had of myself as a man, a professional, a "partnered" boyfriend protected by propriety and stability. Ultimately, the larger meaning of the moment, the lesson to be gleaned from the layers of hematoma and laceration, is lost in the effort to stay alive. Perhaps one day I shall be able to look back at this time, this painful year, and honor it with substantial significance, figure the algebra of the dreamwork more effectively. For now, for the moment, I am happy just to have survived.
As nature busily propagates, as the vine climbs upward, so do I too plan for the future under the regime of summer heat, making hay while the proverbial sun shines. At the end of this week, I begin a long road trip striking several points on my personal archipelago, with a combined 52 hours of driving over two weeks. The symbolic value of this journey is both literal and figurative, a closing of the book, a turning of the page, the curtain call on a particular and in some ways peculiar year of personal examination, lost in hours of interstate driving. It is a refusal of totemic signs, a turning away from the talisman, and an emergence into something else, something new, a creature similar but different, the relearning of upright walking— an end to my own personal year of magical thinking and a return to the material world.
13 comments:
- Flavia said...
Thinking of you, as always, and hoping the next year--and the year after that and the year after that--bring you every imaginable compensation. Or at least peace.
I've been encountering bad anniversary after bad anniversary for 2.5 months now--the last one comes in just a little over a month, and I'm so ready no longer to be thinking in terms of what was happening "a year ago today." I mean--who thinks of what was happening "a year and six weeks ago today"? Not me, I hope, and hopefully not you either.
- Wed Jul 30, 12:23:00 AM
you are strong and beautiful and you will get through it.
- Wed Jul 30, 12:51:00 AM
I hope the good times you've had this past year can someday overshadow the trials...
- Wed Jul 30, 01:21:00 AM
You don't know me, but I've also been through an incredibly shitty 18 months in which virtually every aspect of my life has been stripped away. I can only say this for your comfort: we still learn the most during hard times, and it is hard times that force us to return to substance and essence and principle. You are not being transformed, but consolidated to what matters. Take heart from that.
- Wed Jul 30, 08:44:00 PM
- adjunct whore said...
What doesn't kill you makes you stronger, goes the truism, but what gets missed in such haimische dichos is the scar tissue that remains: thickening, constraining, disfiguring.
yes. i can't remember when i finally realized this but it wasn't long ago, perhaps also within this past year. and it's a stunning realization saying as much as it does about who you are and can ever be.
your posts always move me but none more than this one. as i did reading the year of magical thinking (the perfect description of trauma), i cried.
to survival, oso raro. enjoy some summer.
- Wed Jul 30, 08:55:00 PM
- adjunct whore said...
if you've time before you go, you've been tagged.
- Wed Jul 30, 09:31:00 PM
- momo said...
Buen viaje, y un abrazo muy fuerte.
- Fri Aug 01, 12:23:00 AM
Soon you will be in Montreal so La Voix and I can spoil you with luscious treats and a safe haven from your 'misadventures' in the midwest. Although, this year is very trying for you I do think that in a very odd way you are currently laying the foundation for you to thrive in the future. Hopefully your trip will in the very least give you a new perspective to enjoy the fall semester. Can't wait to see you.
- Fri Aug 01, 04:54:00 PM
- New Kid on the Hallway said...
I have no words of wisdom, just sympathies on the shitty year. And also gratitude, that you linked here to your posts about academia/marriage, which led me to reread them for the first time since I've decided to leave academia, and which I appreciated anew, from a different perspective. It was a wonderful feeling to read them as someone who doesn't have to maneuver that system any more. (I'm sure there are others equally bad, but that doesn't mean it isn't still wonderful to escape this particular one.)
Anyway. 39 is a weird, liminal age. Sending best wishes for the rest of your year.
- Mon Aug 04, 05:33:00 PM
Annus horribilis indeed . . . but now, a time of growth and change. Enjoy your travels, recharge your batteries, and once you return, get that fucking book out so you can blow that popsicle stand and achieve your best.
Quien mas?
- Thu Aug 07, 02:14:00 PM
Beautifully written! I hope you find yourself in a more comfortable and nurturing space this fall. I also hope you will be able to adjust the pace of metamorphosis and buffer its effects a bit.
- Thu Aug 07, 10:46:00 PM
- Professor Zero said...
Wait - so you broke up with Mr. Gordo *and* you had only been together 5.5 years? It seemed like longer, and it seemed permanent, but then I guess 5.5 years adds up ... and breakups always happen at about that point, I notice. HMMMM. Buen viaje de todas maneras.
I had my cards read in Lima and it was epoch making, it said everything was about to change. Maybe you should get your cards read.
- Fri Aug 08, 12:58:00 PM
- Sfrajett said...
Don't ever stop thinking magically, OR. Hejiras always take you some place wonderful. You sound as if you are already reaping the poetic rewards. xoj
- Tue Aug 19, 12:10:00 AM


text:
ARLINGTON, Texas (AP) Left-hander Nate Robertson and utilityman Jeff Baker have agreed to minor league contracts with the Texas Rangers.
Baker hit .266 with 37 homers in 543 games during the last eight seasons with Colorado (2005-09), the Chicago Cubs (2009-12), Detroit (2012) and Atlanta (2012). He hit .239 with four homers and 25 RBIs in 83 games last season.
Baker has started games at first, second and third base and in the outfield.
The 35-year-old Robertson last pitched in the majors in 2010. He was 57-77 in 223 games for Florida (2002), Detroit (2003-09), Florida (2010) and Philadelphia (2010).
Texas announced the agreements Saturday.


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Here's two items to top your 2015 New Year's Gift-to-Self List:
1. Take my on-line class Children's Book Illustration: Thinking in Pictures, via UCSD Extension. You can take it as part of the newly-created Certificate Program in Children's Book Illustration. Or as a self-development work-out. Or as a hands-on means to explore the world of children's picture books. You'll read 8 new books a week, and progressively create 8-page, 16-page, 24-page, and 32-page stories by the end of the course. And you'll meet colleagues who love story, from all over the world.
Registration is open now!
Dates: January 7-March 15, 2015
Register here: UCSD Extension / Art 40634 – 3 credits
Here's a video about the Certificate Program itself:
2. Create a creature, and share it online during KidLit Creature Week. You'll see many familiar names submitting theirs! Complete instructions can be found here. I will be rolling up my sleeves to draw one up . . . and so will my students! Roar!
Here's one from my pal, Debbie Tilley


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A large pro field will ensure IRONMAN 70.3 Barcelona has an auspicious start. On Sunday 57 professional triathletes from 14 countries fight for the first IRONMAN title that will be handed over in this beautiful Spanish city.
Terenzo Bozzone hits the starting line with a clear goal: The New Zealander wants to celebrate his 15th IRONMAN 70.3 title in Barcelona. The 29-year-old took third in his birthday-race at IRONMAN New Zealand on March 1 and seems to be ready to roll (fast).
Among the co-favorites are Sylvain Sudrie (FRA) and Victor del Corral Morales from Spain to hang on Bozzone's shoulder. Corral Morales is not only competing in his home town of Barcelona, but he also sprinted into the world of IRONMAN racing last November with two great IRONMAN victories in only 16 days. First, he cracked the race record at IRONMAN Florida in 7:53:12, then he had another brilliant race at IRONMAN Arizona with another impressivewin in 8:02:00.
Also included in the strong field is Rasmus Petraeus from Denmark, Will Clarke (GBR), Jan van Berkel (SUI) and Markus Fachbach (GER).
The women's pro field looks a little bit like it could be a great comeback-event for Camilla Pedersen from Denmark. The reigning IRONMAN European champion had a horrible crash during her bike training in September, but is now back into racing again. This season she has already claimed one win over the IRONMAN 70.3 distance. Other favorites are Diana Riesler and Katja Konschak from Germany.


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My family home has always been kid friendly. It wasn't the hub of social activity while I was growing up, but there was always something on hand for everyone to play with, regardless of age. Alas, children grow up. My youngest niece is now 15, and it has been years since hordes of children have assembled at my parents' house. Who knew they would prefer my aunt's house, with the indoor pool?
Now I have two boys. One is just discovering that he has feet, but the other – ah, he is a force to be reckoned with. I have watched his imagination grow by leaps and bounds in the past year. He no longer requires my input; he will happily sit while his toys have a conversation with each other, he will race cars on the moon and he will rescue every animal he has, from every possible danger.
At the end of my parents' yard is a shed. In this shed is an old blue box. This old blue box is full of toys that have been collected over the years, thrown in for countless kids to play with. My dad couldn't recall the last time it had been opened, and so was excited to see what was inside. It was a time capsule of sorts, discarded toys from different times in the life of our entire extended family. It was also a complete hodgepodge, consisting of original Star Wars, Masters of the Universe and Pixar. My son played with everything indiscriminately, and everything interacted with everything else. Esmeralda danced with Celia, while a Wampa took a ride on Thomas the Tank Engine. I don't know who had more fun, my son or me and my dad watching him!
You won't win a prize if you can name everything in this box, but you can add an extra notch to your geek credentials if you can tell me what the ship is. We hoard things in my family – it's what we do. I also married into it, so I predict that in 20 years' time, when I open the tote boxes I periodically fill with discarded toys, I might have a surprise or two waiting for me. This old blue box certainly had a lot more on the inside than it appeared to contain from without. What would be in your toy box time capsule?


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Erudition, Humanisme Et Savoir: Actes Du Colloque En L'Honneur de Jean Hamelin
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