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December 2012
The world of stem cells
We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual:
- The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc.
- Each cell of early development is undifferentiated; that is, it is not yet specialized to carry out a specific body function. Cells of early development have the capability to contribute to all of the organs in an individual and are called totipotent.
- These totipotent cells are embryonic stem (ES) cells and have both the capacity to self-renew, thereby maintaining a continuous supply of stem cells, and the ability to give rise to specialized (differentiated) cell types, such as liver cells or brain cells.
- Generally, as cells differentiate and become specialized, they lose their ability to divide.
In addition to embryonic stem cells, stem cells also exist in adults (adult stem cells) that allow specific tissues to regenerate throughout an individual's life. They also have the ability to self-renew and can give rise to a subset of differentiated cells depending upon the nature of the adult stem cell. Such adult stem cells and lineage-specific progenitor cells (with limited self-renewal ability) have long been known to exist in organs that continually regenerate, such as skin and blood. Some adult stem cells are active all the time (e.g., blood), and some only respond to injury (e.g., hair follicle stem cells) or physiological clues such as hormones (e.g., mammary stem cells).
More recently, however, stem cells have been identified in organs previously thought not to have regenerative capability, including reproductive organs. Female infants were previously thought to be born with a finite number of eggs, but a recent report identified egg stem cells in human ovarian tissue that can form egg cells, called oocytes, in the laboratory.1 Many tissues in the adult body (e.g., neural, muscle, and fat tissues) now appear to contain stem/progenitor cells.
The main use of stem cells in medicine is as a source of donor cells to be used as therapy to replace damaged or missing cells and organs. Stem cells are also useful for creating models of human disease and for drug discovery.
Sources of stem cells
Stem cells can be obtained from several sources:
- Spare embryos: Stem cells can come from "leftover" embryos stored at fertility clinics that were not used by couples to have children and may otherwise be discarded.
- Special purpose embryos: Embryos created by in vitro fertilization (artificially in the lab) for the sole purpose of extracting their stem cells.
- Cloned embryos: Embryos cloned in labs using the somatic nuclear transfer method in order to harvest their stem cells.
- Aborted fetuses: Stem cells are taken from fetuses in early development that have been aborted.
- Amniotic fluid stem cells: Cells isolated from the amniotic fluid of pregnant women.
- Umbilical cords: Stem cells taken from this frequently discarded after-childbirth tissue hold potential for future research.
- Adult tissue or organs: Stem cells obtained from the tissue or organs of living adults during surgery.
- Cadavers: Isolation and survival (up to 20 hours after death) of neural progenitor cells from human post-mortem tissues has been reported and provides an additional source of human stem cells.
- Induced pluripotent stem cells (iPSC): Adult differentiated cells (e.g. skin) that are reprogrammed in vitro to form embryonic stem cell-like cells. Reprogramming requires the introduction of several specific genes or small molecules into the differentiated cells.2
Embryonic stem cells must be obtained when an embryo is in early development; that is, when the fertilized egg has divided to form about 1000 cells. These cells are then separated and maintained in a cell culture dish, thereby halting embryonic development toward creating an individual. This is why embryonic stem cell research is the subject of ethical debates, as there is disagreement over when dividing cells should be treated as a person. Utilization of adult stem cells and induced pluripotent stem cells poses less of an ethical dilemma.
Comparing embryonic and adult stem cells
Embryonic stem cells have advantages and disadvantages for therapy.
Advantages: Embryonic stem cells are:
- Flexible: They have the potential to create any body cell.
- Immortal: One cell line can potentially supply endless amounts of cells with carefully defined characteristics.
- Easily available: Human embryos can be obtained from fertility clinics.
Disadvantages: Embryonic stem cells could be:
- Difficult to control: The method for inducing the specialized cell type needed to treat a particular disease must be defined and optimized. Also, embryonic stem cells can cause tumors.
- At odds with a patient's immune system: It is possible that transplanted cells would differ in their immune profile from that of the recipient, causing them to be rejected.
- Ethically controversial: Those who believe life begins at conception maintain that conducting research on human embryos is unethical even if donors give their consent.
Likewise, adult stem cells also have advantages and disadvantages in therapeutical uses:
Advantages Adult stem cells are:
- Already somewhat specialized, meaning that inducement may be simpler in some cases.
- Immune hardy: Recipients who receive the products of their own stem cells (autologous stem cells) will not experience immune rejection.3
- Flexible: Adult stem cells may be used to form other tissue types.
- Mixed degree of availability: Some adult stem cells are easy to harvest and others, such as neural (brain) stem cells, involve harvesting techniques that can be dangerous to the donor.
Disadvantages Adult stem cells could be:
- Of minimal quantity: They are difficult to obtain in large quantities.
- Finite: They don't live as long in a culture as embryonic stem cells.
- Genetically unsuitable: Harvested stem cells may carry genetic mutations for disease or become defective during experimentation.
The surprising property of adult stem cells: transdifferentiation
Adult stem cells were thought to be restricted to producing differentiated cells specific for the organ from which they were isolated. Recently, however, several examples have been reported which demonstrate that these stem cells, under certain conditions, can be induced to form other cell types (transdifferentiation). For example:
- Neural stem cells (NSC) can give rise to blood and skeletal muscle;
- Bone marrow cells can give rise to muscle, liver cells, and astrocytes.
When NSCs were used to form muscle, no inducers were needed other than co-culturing the cells with muscle progenitor cells (myoblasts) or injecting them into muscle. This holds some promise for cell transplantation therapies, as the experiment suggests that host tissue has some ability to instruct transplanted cells to a desired result.
Stem cell therapies
Embryonic and adult stem cells offer the opportunity to transplant a live source for self-regeneration. Bone marrow transplants (BMT) are a well-known clinical application of adult stem cell transplantation for cancer patients. BMTs can repopulate the marrow and restore the blood's different cell types after high doses of chemotherapy and/or radiotherapy, which are used to eliminate cancer cells. Adult stem and progenitor cells are being developed for many other clinical applications, such as:
Figure 1. Skin graft grown in the lab from stem cells, Melissa Maggioni, Yann Barrandon's lab. For more information and educational resources about stem cell research, visit www.eurostemcell.org
Skin replacement One of the most successful applications in medicine of adult stem cells is skin replacement for burn victims. The ability to maintain adult skin stem cells in culture and to grow and expand skin in vitro has been used in the clinic for decades (Figure 1). Recently, more sophisticated approaches have relied on this knowledge and technique.
A combination gene/stem cell therapy approach has been used to treat a skin blistering disease called Epidermolysis bullosa, a genetic disease caused by a mutation in the laminin 5 gene. In this approach, biopsies from the palm of the patient's hands are used as a source of skin stem cells. A normal version of the laminin 5 gene can be introduced into these cells in a petri dish. The cells containing the normal version of the gene can then be grown into sheets of cells in the laboratory and grafted onto the patient. Such grafts were shown to be healthy during a one year follow-up period and resulted in some relief for the patient.4
Immunodeficiency diseases The idea of a combination gene/stem cell therapy approach may be extended for use in induced pluripotent stem cells for other diseases. It has already proven successful for patients with a form of X-linked severe combined immunodeficiency caused by a mutation in the adenosine deaminase gene.5 In such cases, blood stem cells are removed and a normal version of the adenosine deaminase gene is introduced into these cells in the laboratory prior to transplantation into the patient. Patients become immune-competent after treatment.
Proof of this principle was also demonstrated in mice with sickle-cell anemia.6 Induced pluripotent stem cells were created and treated to produce blood stem cells. Gene therapy was used to correct the genetic defect in these cells before performing a bone marrow transplant. Although not yet developed for humans, the approach has potential for the future.
Cell transplantation for spinal cord injury Neural stem cells were thought to be strictly embryonic, but many recent findings have proven this incorrect.7 The identification and localization of neural stem cells, both embryonic and adult, have been the major foci of current research. Potential targets of neural stem cell transplants include stroke, traumatic brain injury, neurodegenerative diseases such as Parkinson's disease, and spinal cord injury.
Christopher Reeve, the actor who famously portrayed Superman, became a victim of spinal cord injury after he fell off a horse. His perpetual support for stem cell research, combined with his celebrity status, brought much public support for stem cell research.
A milestone was hit in 2009 when the US Food and Drug Administration (FDA) granted permission to the company Geron to initiate the world's first human clinical trial of an embryonic stem cell-based therapy for acute spinal cord injury. Rigorous preclinical testing showed the product (embryonic stem cell-derived oligodendrocyte progenitor cells, which can be thought of as neural-supporting cells) was safe and efficient in improving locomotor skills in animal models.8 The neural-supporting cells produce myelin that insulate nerve cells and allow them to send electric impulses; these cells also make products that support nerve cell growth and survival. Importantly, evidence suggested the product would not cause tumors, a potential side effect of using a product derived from human embryonic stem cells.
However, permission was put on hold after Geron reported the observation of tiny cysts at the injection site in some preclinical experiments in rats. After passing further tests for safety, permission to proceed was granted again. Several patients were treated but, soon after, Geron announced they would discontinue the clinical trials because of financial difficulties, leaving a significant hole in the body of work surrounding the use of stem cell-based therapies for spinal cord injuries.
The eyes have it for stem cell therapies
The first embryonic stem cell trial in Europe has been approved for the treatment of one of the main causes of blindness in young people: Stargardt's macular dystrophy. This genetic disease causes the loss of cells, called retinal pigment epithelial cells (RPE cells) that lie underneath the retina. These cells support the health of the rods and cones; loss of these cells leads to the loss of rods and cones and, eventually, loss of vision. The trial—initiated by Advanced Cell Technology—will involve the injection of embryonic stem cell-derived RPE cells behind the retinas of human subjects. Thus, another milestone to test the safety of stem cell therapy in a clinical trial is underway.
Adults' eyes contain limbal stem cells that maintain the health of the cornea, a structure crucial for eye protection and vision. Chemical and thermal burns can result in the loss of these stem cells, as well as normal vision. Transplantation procedures using limbal stem cells from the unaffected eye have been demonstrated to be fairly successful for up to 10 years for those with damaged corneas, though large-scale clinical trials are needed.9
An exciting research report gives hope for further breakthroughs in the application of stem cells for eye disease. Researchers have demonstrated the formation of a three-dimensional optic cup structure (a precursor of the eye) in culture from human embryonic stem cells.10 The fact that the cells organized themselves to form a multi-layered retina with rods and cones that could be then be cryo-preserved moves us one step closer to being able to transplant fully functional retinas.
Figure 2. The first synthetic trachea, developed in the lab of Professor Alexander Seifalian at University College London and seeded with stem cells for implantation into a male patient. The creation of "Claudia's trachea" utilized a similar process.
Claudia's trachea and other successes
The ideal application of stem cells is to use them to replace organs damaged from disease. This has been accomplished in a report that has commonly become known as the story of "Claudia's trachea." A 30-year old woman with tuberculosis received a successful tracheal (windpipe) transplant (Figure 2), which was constructed using a donor trachea from a deceased donor (after removing donor cells and antigens), seeding it with cells grown in laboratory from the patient's own stem cells, and surgically replacing the patient's diseased windpipe.11 The patient did not require immunosuppressive drugs because the cells of the donated windpipe were her own cells. This approach has been extended to treat several patients with tracheal cancer.
Dentistry may someday involve growing your own teeth
The wearing and decay of teeth over a lifetime is inevitable, but the potential for stem cells to replace teeth may not be too far in the distant future. The production of a tooth using non-dental stem cells has been demonstrated in adult mice.13 First, non-dental stem cells were used to construct an embryonic primordium (defined as an organ in its earliest recognizable stage of development) in vitro, and transplantation of the primordium to the mouth of an adult mouse was then shown to form a tooth. The most successful source of non-dental stem cells tested was derived from adult bone marrow, which suggests that growing teeth from a patient's own stem cells may someday become a reality.
Use of stem cells for drug discovery
Liver and heart toxicity problems account for about 30% of drugs that fail in early stage clinical trials, indicating a need for more efficient and successful means of testing drugs for toxicity before clinical trials. Induced pluripotent stem cells can be an important and limitless source of human liver and heart cells for toxicity studies.14 iPSC-derived heart cells are already being used for this purpose but obstacles still remain for generating fully functional iPSC-derived liver cells. The generation of iPSC cells from patients with specific diseases holds promise for better models of each disease and can include different genotypes. Such cells have been created for Huntington's disease, Juvenile diabetes, spinal muscular atrophy, and severe combined immunodeficiency.15
Future directions
The generation of new neurons in the adult brain is limited. However, self-repair of neuronal cell death has been recently demonstrated in mice, suggesting that stem cells normally residing in the brain might be able to be stimulated by inducers in a manner similar to how we induce our immune system by vaccination.3 Such a process would bypass the need for cell transplantation. A search has begun to discover regenerative drugs that can prompt endogenous stem cells to differentiate in vivo and repopulate lost or diseased cells in conditions such as stroke. Some regenerative drugs are already available and others are actively being developed. For example, eltrombopag (Promacta/Revolade) is a small molecule that stimulates the production of platelets from blood progenitor cells, and compounds that stimulate bone differentiation from stem cells are being developed as drugs for promoting bone growth. In the meantime, we eagerly await the elongation of the list of regenerative drugs.
Research is leading us closer to the routine and broad use of stem cells in the clinic but, before this can become a reality, large scale clinical trials for safety and efficiency are needed. Some of the work described above is demonstrated in mice or in a few human case studies. With the initiation of clinical trials such as those for spinal cord injury and Stargardt's macular dystrophy, the journey has begun, but it is important to realize that claims of stem cell wonder treatments are not to be trusted without vetted data from clinical trials and the approval of bodies such as the Food and Drug Administration.
Scientists and stem cell research
Scientists believe that stem-cell research could lead to cures for myriad diseases afflicting humans. Anti-abortion groups, some religious groups, and conservative citizens say that using cells from embryos is immoral because it destroys life. However, a recent poll published in the New England Journal of Medicine showed that 6 out of 10 (62%) Americans believe that medical research involving stem cells obtained from human embryos is morally acceptable and favor conducting medical research that uses stem cells from human embryos, with the majority saying that it should be funded by the federal government.16 The Obama Administration has lifted former-President George W. Bush's previous restrictions on funding, and the legality of that decision was upheld by federal courts, but the future degree of such funding lies in political hands.
Most scientists do not support applications for human reproductive cloning; that is, they do not want any embryos altered during stem cell research to develop past a defined stage. They agree with governments and concerned citizens that it should be banned worldwide. However, they do want the opportunity to continue stem cell research for clinical applications under appropriate regulation and legislation with the hope of alleviating human suffering.


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DAVIS, Calif. – After putting up just three hits as a team in Tuesday's loss to UCLA, the Gauchos offense rebounded in a big way on Thursday afternoon, keying UCSB to a 10-5 victory over UC Davis in the first of a three-game Big West series at Dobbins Stadium.
The 3-4-5 hitters in the UCSB lineup were especially effective, combining to go 7-12 with a whopping six RBI's.
The 10 run outburst made a winner out of Gaucho starter Austin Pettibone, who set a new career high with his ninth victory of the year.
Pettibone was extremely effective early on, facing the minimum through his first 3 2/3 innings and allowing just one run over the first seven frames on a fourth inning RBI single.
After the run in the fourth, he put the clamps back down by retiring nine of the next 10 batters he faced. However, he was victimized by a two-run home run from Austin March as part of a three-run eighth before departing.
He ended the day with a still-strong line of four runs allowed on seven hits in eight innings pitched with four strikeouts and no walks, the second time he has declined to issue a free pass in a start this season.
Barring an unexpected relief appearance, Pettibone will close the regular season with a total of 110 innings pitched, the most thrown by a UCSB pitcher since James Garcia logged 122 innings in 2001. His nine wins are the most by a Gaucho pitcher since Michael Martin went 9-4 in 2004.
Sophomore second baseman Woody Woodward led the way with the bat for the Gauchos. He matched a career-high with four hits, and drove in four runs on the day.
Woodward was the one who got the Gauchos on the board first, collecting an RBI in his first two at-bats on a sacrifice fly and single, respectively.
UCSB broke it open in the fifth, as left fielder Joey Epperson led off the inning with a base hit up the middle, then came around to score on the next play when Aggie right fielder Spencer Henderson misplayed Brandon Trinkwon's single. Woodward followed that up with a run-scoring double before Robby Nesovic singled him in to make it 6-1.
Woodward was at the heart of yet another UCSB rally in the seventh, when he singled to lead off the frame. First baseman Tyler Kuresa singled as well before a Luke Swenson RBI fielder's choice was sandwiched by RBI singles from Nesovic and Marc Venning.
The Gauchos moved to 32-23, 15-10 with the win. Couple with Cal State Northridge's loss on Thursday, UCSB now occupies third place in the Big West standings. UC Davis, losers of four straight, dropped to 19-35, 5-20.
Nesovic will be on the bump tomorrow afternoon as the Gauchos aim for their sixth consecutive series win. UC Davis will counter with righty Spencer Koomans, who has gone 1-8 this year with a 5.56 ERA. First pitch is set for 2:30 p.m.

subset: commoncrawl


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Summer Enrichment
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Summer enrichment course was great. 10/10


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Inspired by Sash and Dash from Designers Dolores Smith and Sarah Maxwell of Homestead Hearth
Quiltmaker: Laura Boehnke
6—9x22" pieces (fat eighths) assorted solids in pink, blue, and green (blocks)
12—8x10" pieces assorted small to large prints in pink, orange, yellow, green, and blue (blocks)
1 yard blue floral (sashing, binding)
1/8 yard multicolor small floral (sashing)
1/4 yard pink tone-on-tone (inner border)
2/3 yard multicolor large floral (outer border)
2-3/4 yards backing fabric
49x59" batting
Finished quilt: 42-3/4x53"
Finished block: 8-3/4" square
Quantities are for 44/45"-wide, 100% cotton fabrics.
Measurements include 1/4" seam allowances. Sew with right sides together unless otherwise stated. {C}


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Keep your business safe without limiting internet access
Using an intuitive color-coded rating system, McAfee SiteAdvisor Enterprise identifies websites that contain malware or other threats such as spyware or phishing scams, alerting you before you click.
Get always up-to-date alerts
McAfee Global Threat Intelligence continually scans the internet with intelligent bots and virtual computers to uncover websites that contain malware.
Gain valuable insight
Our email and download tests inform you if a site contains suspicious links or affiliations to harmful sites.
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When you search with Google, Yahoo, MSN, AOL, Bing, or a variety of other search engines, you get a safety rating next to each search result.
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text: "Automotive Wiring and Electrical Systems" is the perfect book to unshroud the mysteries of automotive electrics and electronic systems. The basics of electrical principles, including voltage, amperage, resistance and OHM's Law are revealed in clear concise detail. All the tools and the proper equipment required for automotive electrical tasks are covered. In addition, this in-depth guide explains how to perform more complex tasks such as adding new circuits, installing aftermarket electronics, repairing existing circuits, building your own wiring harness and troubleshooting. Author Tony Candela explains how to complete popular wiring projects throughout this 144-page softbound guide. More than 350 color photos provide visual assistance for a variety of electrical tasks.


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R-MaaS: Rights Management as a service?
I participated in a panel session this week at the Cloud Computing Summit in Washington D.C. sponsored by the 1105 Government Information Group. Over the course of the day, there was a healthy debate being waged about exactly when and how government agencies should deploy cloud applications. Some postulated that the cloud was merely a marketing term for hosted services that had been around for years, while others believed that significant technology advances such as virtualization make today's cloud computing deployments something altogether different and more valuable. One area that lacked any debate was that the number one area of concern for both commercial and government customers regarding cloud deployments is security. Part of this debate focuses on whether or not applications that housed PII or other highly sensitive information should ever be deployed in a cloud infrastructure due to the assumed lack of control. This topic triggered some thoughts about another way security and the cloud are coming together quickly today: deploying Enterprise security software in the cloud as a managed service.
Perhaps we'll coin the term R-MaaS for now, Rights Management As A Service. There are many layers of security that needs to be built into a cloud infrastructure, from physical security, to access controls, firewalls, and even encryption for archived data at rest. But this concept is using the power of the cloud to actually deploy security tools such as LiveCycle Rights Management, which provides persistent document protection regardless of whether the recipient is internal or ecternal to the organization, regardless of the document type (PDF, CAD, or Microsoft Office) and regardless of where the documents ultimately travel (at rest in storage or file systems, in motion over email or to the web, or in use on laptops or removable media devices). LiveCycle Rights Management as a Managed Service has already garnered a lot of interest as all of the features available on premise are also available in the cloud. This includes the ability to protect documents both inside and outside the firewall via free, widely available Adobe Reader for PDF, support for strong user authentication including VPN access for internal employees and a variety of PKI based authentication mechanisms for identity federation across organizations. As well as the ability to expire or dynamically revoke documents, link users automatically to the latest versions, or even provide anonymous access to particular documents as a way to track how documents are being consumed.
Some of these capabilities customers have been using since 2003, but now in 2010, we have added this new deployment option that not only brings rights management to the cloud, it's actually rights management in the cloud. LiveCycle Managed Services is our new cloud deployment option for LiveCycle that allows customers to deploy software in a simple annual subscription pricing model that includes all hardware, software, maintenance, upgrades, and 24/7 monitoring of the system. We still work with a customer's internal IT and security resources to help build out the appropriate security policies, but the mundane tasks of maintenance and upgrades are performed by Adobe. Besides all the benefits that come with a fully managed service, deployments times can be accelerated from weeks down to a couple of days or less. This allows you to get the application up and protecting documents quickly for the business without the costly delays associated with approvals, hardware and software procurement, and installation.
Now getting back to the original concerns at this week's conference about relinquishing control of sensitive information to the cloud…. Where LiveCycle Rights Management deployed as a Managed Service circumvents these objections is through an elegant architecture that is absent the need to ever house sensitive documents in the cloud itself. In fact, only the document policies and associated keys are stored in the cloud, the documents remain in the organization's datacenter, within their control. Keys are passed back and forth from the Rights Management server sitting in the cloud to allow user access based on the document policies. So what started as an interesting philosophical discussion about whether or not applications which transact sensitive information should leverage a cloud computing architecture, ends with the notion that some of these concerns can actually be mitigated by none other than, the cloud.


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Ariana Grande's music video for "Baby I" is out—and it's so cute! (YouTube)
Rihanna's fall makeup collection for MAC is girly, but still has that statement-making RiRi edge. (Beauty High)
It's Beatle-mania! Check out the latest promo for Glee's new season. (Just Jared Jr.)
One Direction and Taylor Swift made history! Check out which Guinness World Records they broke. (Cambio)
The X Factor's runner-up Carly Rose Sonenclar can SING! Hear her belt out this amazing motown mash-up. (Huffington Post)


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The countdown to the House finale is on, ladies and gentlemen, and if you're starting to well up already, join the club. If not, here's something that might get you going:
In this short video piece, which you'll see first here on EW, the House cast reflects on what they'll miss most about going to the set every day and their characters.
"It's going to be very, very, very sad," says Hugh Laurie. "Most of that has to do with not coming here and seeing these people every day."
And we'll miss them. Check out the video below!
Read more:


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Every week, a DIY expert spares us a trip to the grocery store and shows us how to make small batches of great foods at home.Today, Heather Baird, the photographer and blogger behind Sprinkle Bakes, shows how to make an at-home version of Tootsie Rolls. Heather is the author of SprinkleBakes: Dessert Recipes to Inspire Your Inner Artist.
When Halloween rolls around, I'm usually stuck in the candy aisle trying to decide what kids like nowadays. Besides a tangle of spider rings and an economy-size sack of chocolate bars, I usually leave with a bag of Tootsie Rolls -- more for me than for the trick-or-treaters. It's something I always received in my treat bag as a kid.I love re-creating nostalgic candies at home, and the idea of making homemade Tootsie Rolls has always appealed to me. I came up with my own Tootsie Roll recipe after trying several that seemed too sweet. I ditched the corn syrup for honey and traded in the semisweet chocolate for good quality unsweetened cocoa powder. The end result is a lightly chocolate-flavored chewy candy that is reminiscent of the real thing. And besides melting a little butter, it's a no cook and no bake recipe!The texture of a homemade Tootsie Roll is slightly less firm than its classic counterpart, but no less delicious. The honey is mostly masked by the cocoa flavor but I really love the little nuance it gives the candy. I used wildflower honey but different types of honey will impart different subtleties, so have fun choosing what to use! You can also add a little espresso powder to enhance the chocolate flavor, though this is a more grown-up option and not recommended for kiddie treats.
Homemade Tootsie RollsMakes 22-24 pieces½ cup honey¼ cup plus 2 tablespoons unsweetened cocoa powder, sifted1 teaspoon pure vanilla extract1 tablespoon unsalted butter, melted¼ cup powdered sugar, siftedPinch of salt1 to 1 ¼ cup instant non-fat dry milk powderIn a large bowl, combine honey, cocoa powder and vanilla using a whisk. Add the melted butter and whisk until well incorporated. Add in the powdered sugar and pinch of salt; whisk again until well combined.
Using a wooden spoon, mix in the instant milk powder ¼ cup at a time until a dough forms. When you can no longer stir the mixture with a spoon, knead it with your hands. Keep adding in milk powder until a firm dough forms. You may not have to use all the milk powder. The finished dough should be firm and a little sticky but not so sticky that you can't handle it. Roll the dough into a ball and place on waxed paper lightly sprayed with cooking oil or coated with butter or vegetable oil.
Let dough rest uncovered on the wax paper for 5-10 minutes. As the candy stands it will relax from a ball shape into a disc. Cut candy into ¾-inch strips and then into 2-inch lengths. If candy sticks to the knife, spray it with cooking oil or coat it with butter.
Cut wax paper into 3 ½ x 5 inch pieces. Wrap candies with the wax paper pieces.
Store candies in an air-tight container in the refrigerator. Bring to room temperature before serving.Save and print the recipe here.Heather will be answering questions about Tootsie Rolls on the Hotline for those of you who want to take on this project at home. For the quickest response, go to her recipe and ask a question from there -- we'll email her your question right away!
See what other Food52 readers are saying.


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At about 17 stories tall, a water slide opening this spring in the Midwest is being touted as a contender for the fastest in the world.
KANSAS CITY, Kan. (AP) ? At about 17 stories tall, a water slide opening this spring in the Midwest is being touted as a contender for the fastest in the world.
The Schlitterbahn water park and resort company is keeping the ride's exact height secret until an official measuring event this spring, The Kansas City Star reports. But officials promise it will exceed the height of the current world-record-holding slide ? the Insano, Spanish for Insane ? at Beach Park outside the city of Fortaleza, Brazil. Riders on the Brazilian slide have been clocked at 65 mph ? a speed Schlitterbahn vows it can top.
Thrill seekers will get their first chance to ride the Verr�ckt ? German for insane ? when the Kansas City, Kan., water park opens May 23. The company hopes the ride will become a destination attraction.
"We have always been family friendly, but this will attract those adrenaline junkies who are always looking for that next biggest, coolest thrill," said Layne Pitcher, the park's director of marketing and sales.
After a 264-step climb to the deck at the top of the tower, riders will hurtle downward in four-person inflatable rafts. At the bottom of the initial plummet, riders will confront a five-story hill. They will be propelled up and over that hill for the final descent to the ride's finish.
Jeff Henry, a Schlitterbahn co-owner who designed the ride, said in a news release that the new slide would be a "game changer" for the industry.
With the construction phase almost complete, Pitcher said the ride will undergo extensive testing before the public is invited to ride it.
"Safety is paramount to us," he said. "We want to provide a thrilling ride, but safety comes first."


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[Intro: Rokamouth]
Beastcoast, Ya Kna ?
Beastcoast Animal, we are the super Pro's
Beastcoast Animal, we are the super Pro's
Beastcoast Animal, we are the super Pro's
Beastcoast Animal, we are the super Pro's
[Verse 1: Capital STEEZ]
I got her in a cobra clutch, she choke it up
Beastcoast baby, I'm an animal, you know what's up
And I don't mean to sound like a dickhead
But I supply the drinks so I already got her lips wet, so sip that
I can make the other two drip sweat
Forgettin' is a sin when the lick start settin' in
You can light a lickle spliff, if you wit it
Don't try to play dirty, it's better if you bring a friend
[Verse 2: Dirty Sanchez]
I'm the nigga that your bitch rolled and she don't wanna switch lanes
Take a lick 'till you make the main vein drip
Rub-a-dub-dub, I'm not a player I just crush alot
Queen Latifah: Are you gonna pass the dutch or not ?
Blood clots from smoking with jamaican girls
She so curvy, curve me, know it's Dirty
I'm not cleanin' up any time soon, do me a favor
Climb it boo, it's hot and you're thirsty
[Verse 3: Kirk Knight]
Man, let me tell you 'bout this girl named rachel
She had a dinosaur smile plus had had the cakey
She said she love Apex but I was never with the fitness
Survival of the fittest, King of the spits like queen of the licks
Keep me lifted, I don't need a wingman
She wanted to be the number one, wait...hold on, suppose to
I'm supposed to hit it once like a monsoon
[Verse 4: Rokamouth]
I keep these girls in check
Remind em' what I do when I'm kissin down they neck
Better not go and hit my phone if I left
Or I'm on to the next, Bustin' cheeks when I flex
Shawty got vexed when I leaked on her dressed
But Roka makes it up when my lips on her breast
Little mama shiver, I be licking down her chest
I Ain't even do my best cause I'm giving her the rest
[Verse 5: Chuck Strangers]
And this a song about bitches
She go up and down like alpine switches
She had more L's than the New York Knickses
Screamin' fuck your schwap, this shit here prescription
Uh, and the pussy had me trippin
Call me Faja, when I hit it like the dutch
She was splitted, never call after I tear it down
Stole her loud
Now we crusin' while you losin' on the way to Dirty house
[Verse 6: NYCk Caution]
Dirty Hoes in they flirty clothes
They give me nerdy dome
Say they got a man but it really don't concern me though
Why you think you got that title for ?
You say that you not a whore
Why am I slapping on your spinal cord ?
Me and her converse, slippin' off my converse
Bandit with the bars, you should listen to this Con's verse
STD won't infect me, I wrap it up when I'm in it
Straight rip up the kitten
[Verse 7: CJ Fly]
I got a few sumchins, I think we got some chance
I never had a russian but she always goin' cum fast
I told her give it to me
She sent it, I smelled it
I hope she don't think this won't damage are friendship
I went in, now it's time to get out
I told her come to my house to show her what I'm about
Little do she know that I heard she was a ho
And I got word of mouth that she go down south
[Verse 8: Joey Bada$$]
Aye yo shawty, come toke this bud
It's the smokers club
She scoped the bus and got so stoked it's us
I'm done talking, spoke enough
Just hope to bust
I won't poke at love I'm a focused thug
Step into my office
Groupie broads can't keep of us
Only thing offered is major label offers
Cause I ain't with selling my soul and my sound
For some pounds and that pretty brown round
[Verse 9: Capital STEEZ]
Girl, lemme entertain your yin and yang
Or i'll dig my fangs in between your frame
If you really into kissing games
You're a fan of my masculine balance
Acrobats of unmasking your talents
Astrosex doesn't count if you doubt it
But I bet you can't wait to find out yet
Your blouse is closer than my house front
And a dime doesn't cost what an ounce does
[Verse 10: Joey Bada$$]
Sweet mother of pearls, and diamonds
Everything was perfect but the timing
From the underworld, came the young minor
Mining his own gold, finding his own soul
Ho try to make me fold, bitch play your own role
Ho's profound cause what the pro found
I been charming princess but you get no crown
It's funny gettin' high cause them chickens so down


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The Daily Startup: Gigwalk Gathers $10M for Army of 'Gigwalkers'
Top stories in today's VentureWire:
Gigwalk was started in 2010 by former employees of Yahoo as a way to connect businesses to contractors, called Gigwalkers. The idea was that these contractors would use their iPhones to gather local information--verifying street names, photographing menus etc.--while going about their daily routines. Over time, the company found that Gigwalkers needed more direction, and a new $10 million Series B funding round is intended to provide that, Deborah Gage reports in VentureWire. The company is now focused on attracting consumer packaged goods companies and directs its Gigwalkers to collect information that's related to their business visibility--how a product display in a store, for instance, is affecting sales.
ALSO IN TODAY'S VENTUREWIRE (subscription required):
Cultivation Capital plans to hire a managing director to lead an effort to raise up to $100 million for a growth fund that would be invested in companies throughout the Midwest, Brian Gormley reports in VentureWire. The St. Louis firm aims to hire a venture investor from a top-quartile fund to lead the fundraising and to set the growth fund's strategy. Access to venture capital is limited in the Midwest compared to the coasts, creating opportunity for a fund with this strategy.
Qiming Venture Partners has secured $500 million for its fourth dollar-denominated fund to invest in Chinese companies, according to a person familiar with the situation, Sonja Cheung reports in VentureWire. The vehicle's amount surpasses the expectations of some investors, who a few weeks ago said the fund could close in the $400 million to $450 million range.
Pley, which allows people to rent Legos for a monthly fee, has raised $6.75 million in venture funding.
Stir, maker of a "smart desk" that moves to accommodate sitting or standing levels, raised $1.5 million in seed funds from investors including Tony Hsieh's Vegas TechFund.
Shares of Akebia Therapeutics closed 57% higher than the IPO price, after the anemia therapeutics maker sold an increased number of shares at the top of the expected price range.
SharePractice, the developer of a "social medical reference" tool for doctors, has come out of stealth with $1.3 million in seed funding.
FuturePerfect Ventures is raising a maiden $50 million fund, according to a regulatory filing.
(VentureWire is a daily newsletter with comprehensive analysis of all the investments, deals and personnel moves involving start-ups and their venture backers. For a two-week trial, click here.)
How Does Airbnb's $10 Billon Valuation Size Up? The online apartment rental company, which is in talks to raise a huge financing round, is now tied with Chinese smartphone maker Xiaomi and cloud-storage company Dropbox for the highest valuation among private companies, the WSJ's Scott Austin reports. At a $10 billion valuation, Airbnb would be valued at more than some of the hotel chains it is increasingly competing against.
AngelList Syndicates--Six-Month Report: When investing platform AngelList launched its Syndicates program six months ago, investors flocked to commit money to some prominent names in the seed-stage game. But so far those syndicators haven't made any deals. "I think some [investors] assembled syndicates but didn't know what to do with them," AngelList co-founder Naval Ravikant told StrictlyVC. "I think some are scared because the platform is very transparent. [An investment] is going to be tracked. People will see the deal in detail. There's no hiding anything, and it causes people to freeze up a bit." He expects the program to hit its stride next year.
Data Science in Venture Capital. With data analysis playing an ever-greater role in building companies, it's natural that venture capitalists would look to apply data to investing. But VCs always talk about how it's all about an entrepreneur's drive, grit and persistence. So where does data fit? Donald Fischer, general partner at General Catalyst Partners, offers some thoughts, and notes that his firm is looking to hire a data scientist.
Tech Publishing Titan and VC Pioneer Passes Away. Patrick McGovern, whose tech-world magazines both chronicled and helped define the rise of the computer age and who made the world safe for "Dummies," died Wednesday, the WSJ reports. He was 76. In addition to being founder and chairman of International Data Group, the publisher of Computerworld, Macworld and the "For Dummies" instructional series, Mr. McGovern in 1992 created one of the first venture capital funds in China.
Some big names in tech -- Elon Musk, Mark Zuckerberg and Ashton Kutcher -- are investors in a $40 million round for Vicarious FPC, a secretive artificial-intelligence company, WSJ's Reed Albergotti reports. Venture firm Formation 8 led the deal.
Write to Zoran Basich at firstname.lastname@example.com. Follow him on Twitter at @zoranbasich


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The Fiat 500X is available with three different trim levels: Pop, Trekking, and Lounge. Standard power for Pop models is a 1.4L turbocharged four making 160 horsepower and 184 pound-feet of torque. It is the same unit that powers the 500 Abarth, though in the 500X it's connected to a six-speed manual, rather than a five-speed. Trekking and Lounge have a 2.4L 4-cylinder that makes 180 horsepower. The bigger engine is optional on the Pop, and it puts power to a 9-speed automatic. Front-wheel drive is standard on all 500Xs, with all-wheel drive optional on Trekking and Lounge trims.
Despite the smaller engine, Pop models still have decent acceleration, thanks in part to the 500X's relatively small size and light weight. Despite being the most basic trim, Pop models still come relatively well equipped for the price. Standard features include power windows and mirrors, an electronic parking brake, hill start assist, steering wheel mounted audio controls, a 3.5-inch screen in the gauge cluster, 16-inch wheels and daytime running lamps.
The next trim level up is called the Trekking trim. Trekking adds the bigger engine and automatic transmission and makes all-wheel drive a $1,900 option. It carries a more rugged appearance, and it also gets unique 17-inch wheels, a 6-speaker Uconnect stereo, and a 5-inch color touchscreen display in the dashboard.
Lounge models ditch the rugged appearance of the Trekking trim and instead add some additional exterior chrome and daytime running lamps. Other features on the Lounge include automatic headlights, a leather-wrapped shift knob, a 6.5-inch touchscreen display, one year of SiriusXM radio and a backup camera.
Popular options on the 500X add items like automatic headlights, Bluetooth hands-free connectivity, leather upholstery, and a rear camera and parking sensors. Trekking and Lounge trims can also be ordered the Advance Safety Package, with blind-spot monitor and rear cross-traffic alert, forward collision warning, a lane departure warning, and more. The Premium Package includes a dual-pane power sunroof, 18-inch alloy wheels and a 9-speaker Beats sound system.
The Fiat 500X comes standard with a host of airbags, anti-lock brakes, stability control and traction control.
Compare Avondale, AZ Car prices. Get free price quotes for any Car in Avondale, AZ. See the invoice price, MSRP price, and clearance prices for all vehicles. Save big when Avondale, AZ Car dealerships compete on price. Compare Car prices, pictures, reviews, local rebates and incentives, and more.
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MotoGP 09/10 – Trophies
PlayStation 3
Complete each requirement to receive the Trophies.
Trophy Description 1UP (Gold) Complete a full Arcade mode season without using a continue. Back to my place...? (Bronze) Host a multiplayer race. Beat the 'Fun Vampire' (Bronze) Beat a time of 01:19.78 on Donington in Time-Trial Mode. Blackjack (Bronze) Win 21 races online. Bohemian Unlike You (Bronze) Cross the finish line separately from your bike. Bon Voyage (Silver) Ride over 100 miles. Boy Done Good (Bronze) Win on your home circuit in Career Mode. Brand (Bronze) Choose your own team leather, helmet, livery design and paint with your own selection of colors. Centurion (Silver) Complete 100 races in any game mode. Champagne! (Bronze) Win a race against a full grid of human riders. Cheers (Bronze) Excited isn't the word... Corporate Cartel (Bronze) Obtain a full complement of sponsers. Doppelganger (Bronze) Finish a race with each rider in the game. Draughter (Bronze) Spend a total of 10 minutes slipstreaming in Arcade mode. Dude, Where's My Bike? (Bronze) Come to a standstill over 100 yards away from your bike after a crash. Dynamic! (Bronze) Complete over 50 dynamic race objectives. Egg-Head (Silver) Fully upgrade a MotoGP class machine in Career Mode. Endo-Rider (Bronze) Do an endo lasting at least 50 feet on a motorbike. Famed (Silver) Obtain a reputation level of 20 in career mode. Find Your Own Way (Bronze) Create a custom racing line in time trial that you then go-on to use in any other game mode. Halcyon (Bronze) Win a race with no penalties - all clean sections, no crashes, no collisions. Insert Coin (Bronze) Use a continue and then finish first in Arcade Mode. Jump through some hoops... (Bronze) Successfully perform every type of dynamic race objective. Legend (Gold) Win a MotoGP class season in Career mode. Middle Management (Bronze) Hire a full compliment of staff in career mode. Mirror, Signal, Maneuver (Bronze) Get every type of time bonus within the same lap on Arcade Mode. Mr. Consistent! (Bronze) Finish 10th or better on every race in a season. Nicky Hayden (Gold) Win 69 races online. Niko Wheelie (Bronze) Do a wheelie lasting at least 500 feet on a motorbike. Notorious (Bronze) Obtain a reputation level of 10 in career mode. Out Runned (Bronze) Finish a race with more time than you started with in Arcade Mode, without using any continues. Owned (Bronze) Use your own Career Mode motorbike and rider in a multiplayer race. Panning For Gold (Bronze) Win a race at each track. Photo Finish (Bronze) Finish a race within 0.1 second of another rider. Power UP! (Bronze) Earn more time between timing-out and using a continue in Arcade Mode. Pro (Silver) Win a 250cc class season in Career mode. Rookie (Bronze) Win a 125cc class season in Career mode. That's A Rep (Bronze) Obtain a reputation level of 1 in career mode. The G.O.A.T. (Gold) Obtain a reputation level of 30 in career mode to become the greatest of all time. The Ultimate Prize (Platinum) Complete all other Trophies They Made Me Do It (Bronze) Complete a full season in championship mode. Top of the Class (Bronze) Obtain an 'A' class rating in all three sessions of a race weekend in career mode. Unravel (Bronze) Unlock the MotoGP class in any game mode. Victory (Bronze) Your first win. Water Sports (Bronze) Win a wet-weather race. Wind Tunnel (Bronze) Go over 207mph.
Contributed By: Guard Master.
Know Something We Don't?
You can submit new trophies for this game and help our users gain an edge.
Have We Been Fooled?
You can submit a problem report for any non-working or fake item in the lists above.


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Learn how to reduce flooding, prevent pollution, and beautify your yard and community!
At this workshop, you will learn about easy and effective ways to enhance your residential or business property, manage rainwater onsite, and help improve local water quality. These practices are designed to be affordable and easy to maintain—if not easier than your existing property features! Come learn from the experts.
We will also be raffling off five 55-gallon rain barrels at this workshop! All guests will receive one FREE entry into the raffle. Snacks and prizes will also be available at the workshop.
This event is FREE and open to the public, but please RSVP as space is limited.


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21 iconic women of the stage, page and screen
For International Women's Day, Fairfax's entertainment team selects our female icons of entertainment, arts and culture for 2013.
Our criteria were deliberately broad: the women we chose had to be still alive but could be from anywhere.
What about that troublesome tag "icon"? Do we mean role models? Popular? Powerful? Beloved? Our icons are almost certainly all those things. We'll leave the last word to the trusty Oxford dictionary, which carries this definition: "An object of particular admiration, especially as a representative symbol of something (a literary icon of the 1970s)".
Cate Blanchett
As she shuffled on stage at January's AACTA awards in a tight, bright-red Armani sheath, an out-of-breath Cate Blanchett joked: "You hit 40 and it's all downhill from there." But at 43, the regal Melbourne-born, Sydney-based actor remains as in-demand as ever. Coming soon are two more instalments of Peter Jackson's The Hobbit trilogy, a new Woody Allen film and a project with Terrence Malick. Little wonder she stepped aside from the co-artistic director role at the Sydney Theatre Company last year, though she will continue to appear on stage. Up next is Jean Genet's The Maids in June, with Isabelle Huppert. We can't wait.
Tina Fey
Forget Carrie Bradshaw – for relatable single female characters on contemporary television, 30 Rock's Liz Lemon nailed it. Comedian Tina Fey's goofy, unlucky-in-love TV writer (in a sitcom she created) is pure, understated feminist genius; bitingly funny but not sanctimonious. The first female head writer in the 22-year history of legendary comedy series Saturday Night Live, (for many of us outside the US, our first exposure was the 2004 film Mean Girls, which she co-wrote and starred in), Fey is one of the most talented producers, actors and comedians in a still male-heavy industry.
Helen Garner
Now 70, Helen Garner has been a role model for generations of Australian women (and men) as a writer of exquisite, muscular fiction, non-fiction and journalism, as a feminist and a contrarian. From her first novel, Monkey Grip, in 1977 to her recent books The First Stone, on sexual harassment, and Joe Cinque's Consolation, about a murder case, she has looked piercingly into the dark and tender parts of human relationships. She reveals her own frailties as frankly as those of the world she observes in stories where we can all find ourselves. If she is controversial it is because of her uncompromising honesty.
Hilary Mantel
British novelist Hilary Mantel shot to critical and popular stardom with her ninth and 10th novels, Wolf Hall and Bring Up the Bodies, which made her the first woman to win two Booker prizes. Her fictionalised life of Thomas Cromwell and the court of Henry VIII crackles with the intrigue of politics and intimate details of character and conversation. Despite chronic illness, she has reinvented historical fiction and assured women that intelligence is beauty and middle-age can be a new beginning. Her recent comments that Kate Middleton (the Duchess of Cambridge) was a "shop window mannequin" were seen by some as harsh but were a bold call for greater freedom for Britain's queens.
Adele isn't that special because she won't play along with the stick figure rules for pop singers or has a voice of power and depth. Nor is she that special because she bares every aspect of her fraught relationships in lyrics that make everything universal. Those are admirable qualities, certainly, and rare enough in these days of pre-fab, karaoke pop. What makes Adele Adkins something beyond regular is how she refuses to let anyone else's expectations rule her life. You can see it in her style, feel it in her willingness to admit fear and hear it in her expletive-filled stories and in that wild laugh.
PJ Harvey
The uncompromising British singer-songwriter Polly Jean Harvey has feathers in her cap that no other person can boast, not least winning Britain's prestigious Mercury music prize twice. Harvey became the first woman to win the Mercury, in 2001 for Stories from the City, Stories from the Sea. A decade later she repeated the feat with Let England Shake. She also earned nominations for two albums in between. Her strident first album, 1992's Dry (which spawned the brilliant, howling single Sheela-Na-Gig) and the macabre To Bring You My Love still stand up just as well today.
Jacki Weaver
Jacki Weaver has been a kind of icon since the 1970s via such films as Caddie, Stork and Alvin Purple - an immensely likeable and talented actress who revealed just how colourful her life was in the 2005 autobiography Much Love, Jac. But as well as a strong body of theatre work, it's her career resurgence since shining as Janine "Smurf" Cody in Animal Kingdom (above) that cements her status. With two Oscar nominations in three years and a string of strong Hollywood roles, she is evidence that character and talent will out – even after turning 60. And by all accounts she remains as likeable and charming as she was way back then.
Kathryn Bigelow
Kathryn Bigelow has an Oscar for best director, which makes her unique among women filmmakers. But that's not what's interesting about her. She has made distinctive and inventive genre films, full of kinetic energy and visceral physicality. She explores stories of obsession and transgression, and she is drawn to tightly knit groups, often on the margins, united by unlikely bonds of community, whether they are vampires (Near Dark) or Zen surfer bank robbers (Point Break). And although she often focuses on male protagonists, she has created some striking, unusual roles for women, from Blue Steel to Strange Days to Zero Dark Thirty.
Magda Szubanski
A cabaret-style sketch comedy performer at Melbourne University in the mid-'80s, Magda Szubanski has established herself as one of Australia's most loved comedy, television, film and musical stars. She is an inspirational and surprising success story, proving talent can always win out. In her own words: "I'm overweight. I'm short. I'm gay. I've got a funny name. It is surprising to me that someone like me would be in that place." Szubanski was widely lauded last year when she came out on national television, maturely discussing her sexuality in an effort to promote tolerance and gay marriage.
J.K. Rowling
Joanne "J.K." Rowling became a hero to children, English teachers and wannabe authors worldwide when a book series she started writing in cafes and completed on an old typewriter took her from clinical depression and social welfare to the life of a philanthropic multimillionaire and Britain's bestselling author in a matter of five years. The idea came to her on a train ride to Manchester and her seven-year quest to write the first novel, overcoming a litany of obstacles including the death of her mother, is inspiring. The Harry Potter novels and films are now the benchmark for blockbuster franchises worldwide, and Rowling is one of the most influential women in Britain, but also one of the most admired women in the world.
Kylie Minogue
Loved by girls, guys, gays and grandmothers, Ramsay Street's most famous alumnus celebrated her 25th anniversary in the music industry in 2012. Whatever you think of her music, it's hard to dislike the singing budgie-turned-battler, the woman who morphed from girl-next-door to chart-topping sex symbol with seeming effortlessness and an admirable touch of class. Her recent performance in Holy Motors hints at an as-yet untapped acting talent, but the 44-year-old is not hanging up her stilettos just yet - this year she was signed to Jay-Z's venerable Roc Nation label, with a new single and album reportedly on the way.
Oprah Winfrey
You know someone is an icon when they are known the world over by their first name. Her enormously successful Oprah Winfrey Show broke all records. It was on air from 1986 to 2011 and had the highest ratings in history for a program of its kind. With those ratings came followers worshipping at Oprah's self-help mantel. At her peak of popularity, Oprah was considered the most influential woman in the world. Her shows were seen by 46 million people every week and she was without doubt the richest African American in history, and most admirably, a great philanthropist.
Asher Keddie
In the past couple of years, Keddie has been all over our screens with a lead role in the Ten Network's Offspring, as Blanche d'Alpuget in the telemovie Hawke and, most memorably, as Ita Buttrose in Paper Giants: The Birth of Cleo. But what seems like overnight success has been almost three decades in the making, starting with the 1980s television series Five Mile Creek. One of our most prolific and versatile actors, Keddie shines in everything from crime procedurals and police shows to nuanced dramas such as Love My Way. Her star burns brightest, however, when she portrays real-life Australian icons.
Leigh Sales
When political strategist Graeme Morris branded Leigh Sales a "cow" for her tenacious interview with Tony Abbott on ABC's 7.30, he caused a minor storm. Fortunately, Sales brushed off his sexist remarks to forge her reputation as this country's best political interviewer (winning a Walkley Award to boot). Tenacious and thorough, she unfailingly demands real answers in place of the carefully scripted soundbites most politicians proffer. What's more, she appears to be enjoying her job – as is evident in her energetic demeanour and engaging screen presence. Former 7.30 host Kerry O'Brien was a tough act to follow, but Sales has taken Aunty's flagship current affairs program to new heights.
Deborah Mailman
If there was an award for best smile, she'd win it hands down. Mailman radiates a certain inner joy, something only ever dimmed by her deliberate acting, when she can bring complex and compelling emotions to the fore. From her breakthrough role in the film Radiance, for which she won an AFI award, to her much-loved character Kelly on The Secret Life of Us, she won over Australian audiences. Throw in other roles from television's Offspring to films Bran Nue Dae and the smash-hit The Sapphires, for which she again won an AACTA (formerly the AFIs) this year, and we can't get enough of this wonderful performer.
Kate Champion
Kate Champion, 51, is no dancing prima donna. She creates and choreographs dance pieces as engaging as they are accessible. The daughter of a Sydney University psychology professor, Champion was clumsy as a child before she enrolled in local dance classes, and at 16 joined Munich's Iwanson Dance Company. She got her break dancing in a touring show with Kim Carpenter's Theatre of Image. In the '90s she began devising her own dance shows, and by 2002 had created Force Majeure, an influential Sydney modern dance company. Her show Never Did Me Any Harm was a funny physical theatre examination of parenting and chimed with anyone who's ever been in a family.
Lady Gaga
No list of iconic women in entertainment could hold its head up without including Stefani Germanotta. Call her a pop singer, dancer, designer, LGBT activist . . . whatever, but you can't ignore Lady Gaga. Responsible for some of the biggest hits of the past five years, her sophistication, wit and sheer bravery leave her head and shoulders above almost all her contemporaries. Her roots are pure New York performance art, inspired in part by the likes of Marina Abramovic and Yoko Ono and, although she seems to have been around forever, it comes as a shock to remember she is only 26 with, hopefully, a long and fascinating career to come.
Dame Judi Dench
In an era when notoriety and bad behaviour are so often passed off as talent and star quality, thank god for Dame Judith Olivia Dench. With a career dating back to 1957, Dench deserves her icon status on longevity alone. But it is the breadth and quality of her work over 50 years that really makes her shine. While modern audiences will know her primarily for her pitch-perfect role as spy chief M in recent Bond movies, she can also lay claim to a long and distinguished Shakespearean career and a successful run in TV sit-coms. Outside her work, Yorkshire-born Dench has always been a byword for dignity and class.
Judith Lucy
In the publicity conscious entertainment world, where image sometimes seems more important than talent, Judith Lucy stands out. A comic who says what's on her mind and tells frank and funny stories that show her in a far-from-flattering light is to be appreciated. Who else would call shows I Failed!, Nothing Fancy and Judith Lucy's Not Getting Any Younger? Well, no one not called Judith Lucy for a start. The films Crackerjack, Bad Eggs and The Sapphires, her TV work on The Late Show, Rove, Judith Lucy's Spiritual Journey and Agony Aunts, her one-woman shows, radio gigs and the book The Lucy Family Alphabet all demonstrate a very Australian comic sensibility and a blistering honesty.
Julia Morris
Despite the bang-up title – "Lady", literally purchased on the internet in 2003 – the heart of Morris' power lies in her relatability: she is everywoman. A mother, a wife, a former single girl and a comedian whose success, when she emerged in the 1990s, challenged the notion that everyone on TV had to be rake thin and blonde. In winning last year's Celebrity Apprentice she revealed her strength and generosity – she shared the prize with the runner-up – and in stepping up to the Channel Nine drama House Husbands proved that with hard work and determination every little girl who dreams of becoming an actress can get her wish.
Ursula Yovich
Singer and actor Ursula Yovich narrated The Secret River at Sydney Theatre in January. "The play brings up a lot of hurt," Yovich, raised by a Serbian father in her indigenous mother's country, Maningrida, far north Arnhem Land, wrote to director Neil Armfield. Yovich, 35, insists she's "not a trained actor by any means", yet she won a Helpmann award for best female actor in a play for her role in Capricornia in 2007 for Belvoir Theatre. Three more Helpmann nominations have followed, including for best cabaret performer in 2011 for her soulful one-woman show Magpie Blues, in which she sang Over the Rainbow in Burarra, Serbian and English, no less.
Written by: Steve Dow, Nick Galvin, Giles Hardie, Philippa Hawker, Michael Idato, Michael Lallo, Garry Maddox, Kylie Northover, Karl Quinn, Annabel Ross, Christine Sams, Susan Wyndham.


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CPT is a professional qualification in the field of "PRO Trading in Financial Market". You are trained by PRO TRADERS.
Read more
CFMP is a comprehensive program for people who want to have a career in financial market but not having knowledge.
ICFM delivers comprehensive training in Trading In International Markets. By virtue of tie up with overseas brokers, ICFM gives you training in Trading in US Markets.
ALGO Trading is the latest and most advanced "Trading Methodology". ALGO Traders are minting money as they are able to execute multiple trades simultaneously.
Equity Trading Workshop is for beginners in Stock Market. You can learn the art of trading in stock market and become an aware and smart investor.
Derivatives Trading Workshop is for those who never traded or know little about Futures & Options Trading opportunities in both Stock Market and Commodities Market.
Currency Trading Workshop opens an other market segment for trading . You get to learn how to trade in major currency pairs.
Technical Analysis workshop is for people willing to enhance their knowledge of trading and want to precise the time of buying and selling with the help of price chart analysis.
NCFM Modules are most popular among candidates willing to have an authentic certification in financial market which could improve.
NISM Modules are given by "National Institute of Security Market " set up by SEBI. These modules add to your knowledge and profile as a certified financial market professional.
NCMP is a superior certification to people who have diversified knowledge of various market segments. It is awarded when you pass 3 or more NCFM Modules.
This is the only authentic certification in the Commodity Market. It is awarded my "Multi Commodity Exchange of India"


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European Union (EU) ErP Regulations - Information for UsersThe EU EcoDesign Directive is legislation that affects all products which consume energy in some form or another. Specific Implementing Measures (Lots) are aimed at controlling and reducing energy consumption of specific products or across multiple product types. In compliance with these Lots or regulations, Dell has provided product information to the public with the attached document, ErP which covers information on test parameters, measurement techniques, and power management features, and other topics not specific to the products.
Product specific information can be found in the Dell Environmental Datasheets found at:
ErP Information


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text: xarthangrol 10 Posted January 12 Hello folks, I'm thinking of buying Affinity Photo for Desktop (Windows), but I'd like to know if the program attempts to collect and/or send any data from users' computers. In these dark days of implied consent and telemetry as excuses to collect data I'd rather know before buying whether or not it does, and if it does, exactly what it does. Thanks. ASUS Prime B450M-K; 16GB Corsair Vengeance RAM; AMD Ryzen 5 2600 CPU; Nvidia GTX1050Ti Windows 10 Professional (64-bit); Manjaro Linux Share this post Link to post Share on other sites


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If the smell of pine tar turns your crank, if you find the crack of a bat as audibly satisfying as a Typhoon album, or if you just like soaking up sun, then Northwest Independent Baseball League games are the place to be. The NWIBL is a competitive wood-bat league that operates like a minor-league system, complete with 17 teams in two divisions, a midseason all-star game, home-run derby and postseason playoffs. Ever since Timbers owner Merritt Paulson chucked the Portland Beavers to Tucson, Ariz., NWIBL has filled the void for local baseball fanatics.
It's easy to root for NWIBL teams because the players play hard, get dirty and hit homers like the pros. Over 200 NWIBL games are scheduled throughout the summer weeks at Portland's nicest public baseball fields, and admission is free for all games played at Walker Stadium in Lents Park (Southeast 92nd Avenue and Holgate Street) and Sckavone Stadium at Westmoreland Park (Southeast McLoughlin Boulevard and Nehalem Street). This family outing is a good way to show kids that the measure of a great baseball player is not the salary, but the way you play the game. This is blue-collar baseball, with teams consisting of college players, ex-pros, and average Joes who love to grind it out on the diamond. When you see a muddy, bloody player walk off the field and gingerly climb into his truck to go home and get up for work the next morning, you know he's in it for the love of the game, not the glory.
The NWIBL season is already under way and runs through late August, with playoffs culminating in a championship game (the Portland Pirates are this year's defending champs).
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- Shell fabric: 100 % cotton
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- Made in Portugal
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This wonderful 2 story 3 bedroom 2 1/2 bath home has lots of room to stretch out in. Master is on the main floor with two bedrooms upstairs. This home has dark cabinets with granite counter tops and stainless steel appliances. The large master bathroom has a double vanity and walk in closet. The backyard is fenced in with room to roam. There is a covered porch in the rear of the home to sip your coffee in the morning.
Specializing in residential real estate we have several Team members that are knowledgeable about specific areas in Northeast Florida. By having several team members we can make sure each customers needs are met.
We also specialize in planned communities including golf, gated, PUD's, family, retirement and boating. Jacksonville, Orange Park, St Johns County, Fleming Island, and Clay County offer so many lifestyles.
Find Out Why More Buyers and Sellers in Northeast Florida are choosing Team Knapp than any other Real Estate Team. Discover what made Team Knapp one of the Top Ten Teams in the Nation and keeps Team Knapp in the Top 10 of Realtors in Northeast Florida year after year.
Call "Team Knapp" TODAY ~ our schedule is Your schedule! 904.334.7426
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There's a saying (made up by me) that goes "how do I know it really happened if I didn't Twitter or Facebook it?".
What I mean to say by that is: technology is important. For everything. Including eating and baking cakes (it enables us to find recipes and post pictures!). My site wouldn't exist without technology. And I'm part of the Verizon Wireless Savvy Gourmets group to celebrate this fact.
And as part of that group, they've offered me a Verizon Jetpack to give away!!
If you win, Verizon will be sending you the Jetpack, a SIM card (needed for activation), a $150 Verizon Wireless gift card (to purchase other equipment or use toward bills), and instructions for how to activate the device.
Now that's totally sweet!
So. the giveaway is open through October 1, at which point it will close and I will announce a winner (I'll choose at random!). For shipping purposes, I am only able to offer this giveaway to US residents. So how do you enter?
It's easy. Simply leave a comment on this post (I have comment moderation enabled, so DO NOT FREAK OUT if it doesn't post right away) stating the following: if zombies were going to attack tomorrow, what dessert would you choose for your last meal?
Fine print about my involvement with the program: I am participating in the Verizon Wireless Midwest Savvy Gourmets program and have been provided with a wireless device and six months of service in exchange for my honest opinions about the product.
Good luck!
UPDATE: The WINNER!
Randomly chosen as the winner was Gwynne! She says her final dessert would be "
might be the frozen Nanaimo bar yogurt, but I think it's a peaches and cream crumble bar. YUM.


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Mike Ballestas' return to the Advanced division was short lived. He and Aaron were tied at -6 going into the second round but Mike bettered his first round score and rolled to victory. Brendan Wear took 3rd place from the second card after being in sixth going into the second round. Mike Holmes achieved his first victory in any division. He began the second round on the second card at even par and was two strokes out of the lead. The lead card stumbled in the second round with the best score being an even par by Jose R. Shooter, also on the second card, shot -1 in the second round to take 2nd place.
Advanced Mike Ballestas -14^ $61.50 shop credit + grab bag Aaron Van Matre -9 $40 shop credit Brendan Wear -5 $25 shop credit Luke -3 Patrick Paramore -3 Ben Farris -3 Quin Henry E Danny Z +2 Augie +3 Adam Cook +3 Serban +3
Intermediate Mike Holmes -4 $40 shop credit + grab bag Shooter -1 $29 shop credit Jose R -1 $29 shop credit Ben Rutherford E $18.50 shop credit Erik Mulhern E $18.50 shop credit Tracy +2 Josh H +4 Nick +5 Sage +8 Donnie +9 Hawk +9 Spence S +10 Shane D +14 Mike T +18
^ Bumped up to next division


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Each year the Kilgore family hosts a barbecue for friends, family and residents of the area. Below are some pictures from the 2006 event.
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The materials on this web site are provided for informational purposes only and do not constitute legal advice. They are not guaranteed to be correct, complete or up-to-date, and you should not rely on them without seeking the advice of an attorney. Use of this site does not create an attorney-client relationship between you and Kilgore Law Office. We have endeavored to comply with all known legal and ethical requirements in compiling this Web site. For purposes of applicable state bar rules, we designate our office in Gate City, VA, USA as our principal office and Terry G. Kilgore as the attorney responsible for this Web site. This web site may be considered an advertisement in some states. Links to other Internet resources do not state or imply that Kilgore Law Office sponsors, is affiliated with or legally authorized to use any trade name, registered trademark, logo, legal or official seal, or copyrighted symbol contained in the links.


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VALLES CALDERA NATIONAL PRESERVE, N.M. (AP) — Visitors line the highway, most peering through binoculars, as they strain to get a better look at dozens of brown specks in the distance.
The specks — members of Valles Caldera National Preserve's infamous elk herd — are munching in green pastures that stretch for miles. They are surrounded by mountain peaks blanketed with ponderosa pine, spruce and fir trees.
The expansive preserve is a sight to behold, but caretakers say Valles Caldera's forests, grasslands and wetlands are not as healthy as they look. Nearly a decade of research has provided them with statistics to say so, and now they have developed a 10-year plan to get the preserve back into shape by using everything from prescribed fire and thinning to weed control and wetland restoration.
The trust has created a special web page that allows the public to review the restoration and management plan and related documents. The public has until Sept. 29 to comment on the plan.
Marie Rodriguez, natural resources coordinator for the Valles Caldera Trust, which manages the preserve, considers it an understatement to say the area's ecosystems are not up to snuff.
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Reaction to Governor's Budget Follows Party Lines
PIERRE, S.D. (AP) - Reaction To South Dakota Gov. Dennis Daugaard's proposed $4.1 billion state budget is following party lines.
The Republican governor proposed modest increases to account for inflation in state aid to schools, funding for universities and reimbursements to hospitals and other facilities that provide medical services to poor people.
House Democratic Leader Bernie Hunhoff of Yankton says the governor's speech to lawmakers failed to address the need to fund schools adequately. He says he hopes Republican and Democratic lawmakers can join forces to find more money for school districts.
Senate Republican Leader Russell Olson of Wentworth says he's pleased the governor has left some money uncommitted. He says he doesn't know how the Legislature might decide to spend that money, but he believes some will be invested in education.
Copyright 2012 by The Associated Press. All rights reserved. Material may not be redistributed.


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Obama Open to Getting Rid of the Penny
(WASHINGTON) -- President Obama says it may be time to get rid of the one-cent coin.
The copper coins cost more to mint than they are worth and are increasingly used less and less, leading many economists to ask why the U.S. hasn't gotten rid of them entirely.
"I don't know," Obama said when asked about it Thursday.
"It's one of those things where I think people get attached emotionally to the way things have been," he said on a Google+ hangout. "We remember our piggy banks and counting out all the pennies and then taking them in and getting a dollar bill or a couple of dollars from it and maybe that's the reason people haven't gotten around to it."
Obama went on to suggest the penny is a "good metaphor" for some of the larger problems facing lawmakers as they seek to reduce the deficit.
"This is not going to be a huge savings for government. But anytime we're spending more money on something that people don't actually use, that's an example of something we should probably change," he said. "One of the things that you see chronically in government is it's very hard to get rid of things that don't work so that we can then invest in the things that do."
Copyright 2013 ABC News Radio


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For food-allergic kids, Valentine's can feel like a minefield of forbidden chocolate. But now they can get their hearts into the day too – with Allergic Living's creative crafts.
Is Valentine's Day is all about chocolates and candy? No! Valentine's Day is about expressing your affection for others. What better way that to create something far more personal than a store-bought goodie?
Just let your imagination go. So gather up those craft supplies, like ribbons and wadded up tissue paper, and pull out your cookie cutters. There's no telling what you might make.
My daughter and I spent a wonderful few hours creating the following. We hope they will inspire your own creations.
Heart-Shaped Crayons
– wax crayons
– muffin tin or silicone pan
- Preheat the oven to 270° F
- Break up crayons into small pieces about ½-inch in length or smaller and place pieces in a heart-shaped muffin tin or silicone pan.
- Put the tin into the oven for 7-8 minutes until the wax has melted. Be careful!
- Remove and let cool completely before taking the crayon hearts out of the pan.
Tip: If you use bright-colored crayons, you will end up with sensational-looking hearts to give to friends.
Heart People
– scissors
– heart-shaped cookie cutters
– glue
– craft foam
– 8 ½ x 11-inch paper
– googly eyes
- Using various sizes of cookie cutters, create your people by cutting several different sized hearts out of craft foam. Glue a medium-sized one onto a larger one to create a frame effect.
- To create the arms and legs, cut 8 strips of 8 ½ x 11-inch paper lengthwise. You'll need two strips per arm or leg.
- Apply glue to a small section of the end of one strip of paper and attach another strip in a right angle position to form an "L" shape. Fold the first strip over the second; the second over the first and so on so that you end up with a stack of accordion-like squares.
- Finish each of the arms and legs by gluing a small heart-shaped foam piece to the bottom.
- Add glue to the top of 2 legs and attach them to the bottom of the heart. Do the same for the arms, attaching them to the towards the middle of the heart.
- Googly eyes and a smile complete the look.
Love Bug
– glue
– toilet paper tube
– red or pink tissue paper
– googly eyes
– craft foam
– party picks
– paper (for banner)
- Cover a toilet paper tube with red or pink tissue paper. Now glue on some googly eyes.
- Use craft foam to create wings that can be glued onto the back of the roll.
- Antennae can be made from party picks.
- Add a banner with a sweet or funny Valentine's message.
Tissue Paper Heart
– scissors
– heart-shaped cookie cutter
– white glue
– pencil
– cardstock paper
– tissue paper (various colors)
- Trace around a heart-shaped cookie cutter on cardstock paper and then cut out the heart.
- Get tissue paper of various colors and cut into 1-inch squares.
- Now place the point of a pencil into the center of your first tissue paper square and twist the tissue paper around it. Dip the point of the tissue paper/pencil into some white glue and press it gently onto the cardstock heart.
- Remove the pencil and repeat until the entire shape is covered with tissue.
Next: More great craft ideas


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On May 28, 96 classic cars left Beijing for an epic race that will take them all the way to Paris.
It's the 5th Peking to Paris Motor Challenge, one of the planet's toughest rally races.
The cars in competition are rarely seen on roads today, and span from a 1913 Ford Model T to a 1982 Renault 4.
They're being driven by teams of two, who hail from 26 countries and are made up of spouses, parents and children, and siblings.
Some are doing it just for fun, while others are raising money for charity (causes include environmental conservation and brain research).
Seven cars were forced to drop out within the first week, but the rest are aiming to reach Paris by June 29.
Standing between them and their goal are 7,500 miles of deserts, mountains, gravel and dirt roads, through China, Mongolia, Russia, Ukraine, Switzerland, France, and more.


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World Smile Archive
Marek Wysoczyński, an initiator of this very unique project has asked us to prepare an identity for his one in a kind collection of 'smiles & autographs'. He believes that this simple act can have a major positive impact on our everyday life. His enthusiasm seems to be shared by many celebrities such as: Pedro Almodovar, Michael Jackson, Liza Minelli, Andrzej Wajda and Lech Wałęsa who supported this cause by dedicating their 'smiles & autographs'. Our major goal was to show the essence of Marek's initiative in the simpliest possible way. We hoped to find a solution that would show the whole idea behind that simple emotion in a single emblem, however we knew that drawing nothing but a smile was not an option even if the whole project seems to be strictly based on it. Although it's not apparent at first, the concept of a helping hand follows, unravelling Marek's true intentions - behind a simple muscle contraction lies a deeper meaning, a desire to help one another, a desire to lend a helping hand. We combined these two ideas into one - a helping hand, carrying and passing the smile on. Aforementioned result served as a basis to create a minimalist and simple emblem which allows others to easily comprehend the whole concept without any unnecessary and misleading elements. Additionally, logo composition was prepared in a way allowing one to isolate a sign with a 'smile word' from the whole logo, which stands alone as a simplified logo version. However, the emblem alone is concise enough to be used without typography.


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Opened in 2010 recognized for its "environmentally innovative design" and is composed mostly of limestone and copper.
Albert Armendariz Sr. Federal Courthouse
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