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CHICAGO (Reuters) - An implantable, wireless microchip delivered osteoporosis medicine to a small group of Danish women, raising hope for a new kind of drug delivery device that might allow patients to skip regular injections, U.S. researchers said on Thursday.
The device, now being developed by privately held Microchips Inc, has a wireless receiver that signals the microchip to release the drug.
"Until now, you never had any way you could do this," said Dr. Robert Langer of the Massachusetts Institutes of Technology, who helped to develop the technology and is a board member of Microchips Inc.
Langer said the device could be used for different types of injectable drugs where getting people to take their medications regularly is a problem.
That is often the case in patients with severe osteoporosis, who tend to skip doses of their medications because they cannot tell whether or not the injections are affecting the density of their bones.
That is something the microchip was designed to overcome, said Robert Farra of Massachusetts-based Microchips, which paid for the study. Farra, Langer and colleagues published a paper on the study in Science Translational Medicine.
Instead of constantly releasing small amounts of drug, like most drug-delivery systems, the microchip releases medication on command all at once, much like an injection would.
It can be activated by telephone or computer using a special radiofrequency reserved for medical use to safeguard against accidental release of the drug, Langer said.
The microchip itself is a thin wafer, about the size of a small coin, made with tiny wells that hold concentrated doses of medication. These doses are covered with a layer of gold nanoparticles, which dissolve when exposed to a certain radiofrequency. The wafer is implanted under the skin with a receiver device that is roughly the size of a heart pacemaker, Langer said.
In the system's first test in people, the team implanted the device in eight Danish women aged 65 to 70 with a severe form of osteoporosis which required injections of Eli Lilly & Co's hormone treatment teriparatide.
The researchers sent daily signals to the microchip device to release the drug for up to 20 doses. Then, they followed up with a period in which the women took hormone injections.
As seen in animal studies, a fibrous collagen-based membrane developed around the device, but the drug still performed just as well as daily injections in the women, improving bone formation and reducing the risk of fractures, the researchers said.
Still, there were some hitches.
John Watson, a professor of bioengineering at the University of California, San Diego, said in an editorial the device failed to work in one of the patients, and that data was not included in the analysis.
And the team had some manufacturing issues and was able to manufacture only one device with all 20 reservoirs filled with the study drug. Even so, all doses in the microchips were released in the patients, a sign that the device could work in people, Watson said.
"Several years are still needed to bring this technology to approval by the U.S. Food and Drug Administration and to the clinical promise reflected in this small study," Watson wrote.
The current device holds only 20 doses, but Langer said the group is working on adding more doses to the device.
The company hopes to have a version of the device on the market in five years. Langer said he sees potential for other uses, such as treating diabetes or delivering cancer drugs.
SOURCE: bit.ly/xUUOwu Science Translational Medicine, February 16, 2012.


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Get to Know Us! Featuring Product Manager, Nancy Balter
How long have you worked at Educational Insights? I started here in 2005, so eight years. What drew you to working here? I was a teacher. I had been a teacher for 11 years and I really enjoyed it, …
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Welcome to GPS
Where honesty, integrity, and ethics are not just buzzwords, they are the words we live by.
Since 1985, we have helped employers hire great people. We can provide the temporary, temp-to-hire, contract, and salaried employees you need to get work done.
Our Experience Is Your Advantage
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Our Mission
Building Solid Relationships by Partnering in Human Resources Management.


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Quick Search: Choose Model and Year, then enter search topic.
Page: 202
Exercise Extreme Caution when Working on your Vehicle
The engine compartment of any motor vehicle is a potentially hazardous area. If you are not fully familiar with proper repair procedures, do not attempt the adjustments described on the following pages.
This caution also applies to the entire vehicle.
Fire and Explosion Hazards
Many vehicle fluids are highly flammable, e.g. fuel, engine oil and transmission oil. Fuel vapours can deflagrate. A highly explosive detonating gas can be formed when charging lead-acid batteries.
Fluid Health Hazards
Refill fluids, e.g. engine oil, brake fluid or coolant, are harmful to health (toxic, irritant or caustic).
Exhaust Gas Inhalation
Engine exhaust is dangerous if inhaled.
Engine exhaust fumes have many components which you can smell. They also contain carbon monoxide (CO), which is a colorless and odorless gas.
Carbon monoxide can cause unconsciousness and even death if inhaled.
Hot Engine Parts, Exhaust System and Fluids
The engine and adjacent components, the exhaust system and coolant become very hot when the engine is running.
The coolant reservoir is pressurised. Hot coolant can spray out suddenly if the coolant reservoir is opened without due care.
Moving Engine Parts
Hands, fingers, items of clothing (ties, sleeves, etc.), necklaces or long hair can be drawn in by moving parts, e.g. the engine-compartment blower, drive belt, etc., when working in the engine compartment.
The engine-compartment blower is mounted on the engine compartment lid.
After the engine is switched off, the engine compartment temperature is monitored for approx. 30 minutes.
During this period, and depending on temperature, the engine-compartment blower may continue to run or start to run.
Carry out work in these areas only with the engine off and exercise extreme caution.
The radiators and radiator fans are in the front of the vehicle.
The radiator fans in the front end of the vehicle may be operating or unexpectedly start operating when the engine is switched on.
Electric Shock from Ignition System
When the ignition is on, all cables and wires of the ignition system carry a high voltage.


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The Indians and their manager, Terry Francona, completed the team's coaching staff. They are bench coach Sandy Alomar, pitching coach Mickey Callaway, hitting coach Ty Van Burkleo, first base coach Mike Sarbaugh, third base coach Brad Mills and bullpen coach Kevin Cash.
Here is the team's e-mailed release:
The Cleveland Indians and Manager Terry Francona today announced the formation of the 2013 Major League coaching staff.
Francona today appointed SANDY ALOMAR (Bench Coach), MICKEY CALLAWAY (Pitching Coach), KEVIN CASH (Bullpen Coach), BRAD MILLS (Third Base Coach), MIKE SARBAUGH (First Base Coach) and TY VAN BURKLEO (Hitting Coach) to the Major League coaching staff for the upcoming season. The staff owns a combined 148 years of experience in professional baseball.
Alomar, 46, begins his fourth season on the Tribe�s Major League coaching staff, having spent the 2012 season in the same capacity. The Cleveland Indians Hall of Fame inductee is entering his 30th season in professional baseball and his 6th in the coaching ranks. During his 20-year Major League playing career from 1988-2007, Alomar hit .273 (1236-4530) with 249 2B, 112 HR and 588RBI in 1377 games. He played 11 seasons with the Indians from 1990-2000, was selected to six American League All-Star teams and caught the third most games (950) in the 112-year history of the franchise.
Callaway, 37, spent the 2012 season as the Tribe�s Minor League Pitching Coordinator in his third campaign in the Indians organization. He was previously the Pitching Coach at Class-A Lake County in 2010 and at Class-A Kinston in 2011 after hanging up his cleats after the 2009 season. Mickey pitched professionally from 1996-2009, appearing in 40 Major League games with Tampa Bay, Texas and Anaheim from 1999-2004 and made 6 starts for the 2002 World Champion Anaheim Angels.�
Cash, 34, spent the 2012 season as the Major League Advance Scout for the Toronto Blue Jays after concluding his playing career in 2011. He enjoyed a 12-year career from 2000-11, including parts of 8 seasons in the Major Leagues with five different teams from 2002-10. The Tampa, FL native signed his first professional contract with Toronto in 1999 and made his Major League debut with them during the 2002 season and was Toronto�s opening day catcher in 2004. He played for Terry Francona in Boston in 2007 and 2008 and caught for Brad Mills in Houston in 2010. In 2008 he appeared in a career-high 61 games, caught all 30 of Tim Wakefield�s starts and homered during the ALCS for Boston.
Mills, 55, is beginning his 35th year in professional baseball, reuniting with Francona after spending the last three seasons (2010-12) managing the Houston Astros. During his first season with the Astros (2010), the Astros finished 59-52 over their final 111 games and finished 1.0 game out of 3rd place in the NL Central. Mills owns 14 seasons of experience coaching or managing at the big league level, having previously served with Francona in Philadelphia (1997-2000) and for five playoff appearances in Boston (2004-09). Mills played collegiately (University of Arizona) and professionally (Montreal) with Francona, compiling a 4-year Major League batting average of .256 (43-168) over 106 games with the Expos from 1980-83 before retiring as a player in 1986.
Sarbaugh, 45, has been a member of the Indians organization since 1990 as a Minor League player, coach and manager and is beginning his first season on the Major League staff. He is entering his 25th season in professional baseball, having guided the Triple-A Columbus Clippers over each of the last three seasons since 2010, leading the Clippers to the International League and Triple-A championships in back-to-back seasons of 2010-11. During his nine seasons (since 2004) piloting Cleveland Minor League affiliates, Mike�s teams compiled winning records in each campaign and captured five league titles. The Shillington, PA native became a coach in the Tribe�s Player Development system in 1995 after a six-year Minor League playing career from 1989-94.
Van Burkleo, 50, owns five years of Major League coaching experience, having spent the last seven weeks of the 2012 season as the Hitting Coach of the Houston Astros after previous stints with the Oakland A�s (Hitting Coach, 2007-08) and Seattle Mariners (Bench Coach, 2009-2010). Prior to his interim stint with the Astros in August he served as the Hitting Coordinator in the Houston Player Development system in 2011-12 and also held the same position with the Anaheim Angels (2001-06). The Oakland, CA native enjoyed a 15-year player career from 1982-96, appearing in 14 Major League games in 1993 (California) and 1994 (Colorado) before beginning his coaching career in the Angels system in 1996.�


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In the name of our entire staff, we welcome you warmly to the Hotel Santangelo. Our hotel provides plenty of parking spaces for its guests. If you are arriving by car, we have free parking directly at the hotel. Make yourself at home Use the lift to access the upper floors of the comfy hotel. The terrace in the garden is definitely a sight to see. Where you will stay Desks are a standard feature in every hotel room. Every single room features a television (cable). For your comfort Our hotel includes an easy-to-use telephone in all of the rooms for you to keep in contact with your loved ones. The bathrooms all have windows in them. Your room's bathroom includes a shower and a blow-dryer for drying your hair afterwards. Baby monitors are provided upon request. Business hours of reception: Every day: from 00:00 to 00:00 .
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text:
Military, Products
By By Andrew Drwiega, International Bureau Chief | July 1, 2014
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Diagram showing AVX Aircraft's offering for the Joint Multi-Role competition. Renderings courtesy of AVX Aircraft
Coaxial compound and tiltrotor aircraft are making news thanks to the U.S. Army's search for the next-generation platform to replace its Sikorsky Black Hawk and Boeing Apache helicopter fleets from 2035 onward.
While both technologies have been around for many years and to differing levels of development, the prospect of winning a contract for between 2,000 and 4,000 U.S. Army helicopters to come into service from the mid-2030s is not something that any rotorcraft company would wish to ignore.
The U.S. Army's Aviation and Missile Research, Development and Engineering Center (AMRDEC) launched the multi-phase Joint Multi-Role technology demonstrator (JMR TD) program, which is expected to lead eventually to Future Vertical Lift (medium variant).
The declared intent is to down select two of the four companies who are competing by the end of June, and they will go forward to produce a flying technology demonstrator by 2017. There are four competing teams during this first phase (for all the principle players are supported by their own industry teams – some of whom are on more than one team). They are: Boeing/Sikorsky; Bell Helicopter; AVX Aircraft; and Karem Aircraft (about which perhaps the least is known).
The fact that the JMR TD Phase 1 competition has come at a time of sequestration in the United States, as well as an economic downturn in Europe, has resulted in a reassessment by all concerned about how the objective will be reached. The two main European manufacturers, Airbus Helicopters and AgustaWestland, are not competing – at least not at this stage. Airbus' management continues to stress that the company is pushing forward with its own research after the successful flight of its own technology demonstrator aircraft, the X³ high-speed compound helicopter. Meanwhile, AgustaWestland is modifying what Bell would call its second-generation tiltrotor, the AW609, although there are currently no plans to militarize the aircraft.
While not in the first phase of JMR, it is too early yet to tell if both the European companies will not have a role to play in the eventual development of the FVL (medium) aircraft.
Rather than tackle this challenge independently, Boeing and Sikorsky have teamed up to offer a coaxial compound helicopter based on Sikorsky's own technology demonstrator, the X2, which flew from August 2008 to July 2011 completing 23 test flights and logging 22 hours airborne. It is not the first time that the two organizations have teamed up over a rotorcraft research project; the RAH-66 Comanche program is well documented.
To do this, Boeing had to move away from its partnership with Bell Helicopter and the V-22 program. Both Boeing and Bell are keen not to make any impression that the V-22 has nothing but a bright future, particularly for foreign military sales (FMS) countries such as those who have already expressed an interest including Israel, Japan, the United Arab Emirates and Qatar among others, any further technical advances could potentially be fed by Bell into its V-280 Valor JMR offering which will directly complete with the Boeing/Sikorsky Defiant.
Recently, Rotor & Wing had the opportunity to talk to the current head of Bell Helicopter, President and CEO John Garrison, who leads the strongest tiltrotor challenge, and AVX Aircraft's president and chief engineer Troy Gaffey, himself a 38-year Bell veteran but now championing his company's coaxial compound helicopter (CCH).
Bell Helicopter has firmly kept to its strength as a champion of the V-22 and continues this technology focus with the launch its third generation V-280 Valor tiltrotor. Garrison describes it, though, as a clean sheet design using 55 years of tiltrotor experience and that of the team behind it.
Illustrating the point about teaming on the project, Garrison said that 'Team Valor' includes Lockheed Martin, which is "a significant investor who is bringing technologies from the Joint Strike Fighter (JSF) world." He added that Spirit AeroSystems is bringing the strength of its experience in structures, which would help to "attack cost points." The partner list also includes GE engines, GKN Aerospace, Moog, Astronics Advanced Electric Systems, Meggitt and Lord Corporation.
Showing the progress the company has made, a full-scale mock-up was displayed at this year's American Army Aviation Association (Quad-A) Mission Solutions Summit during May in Nashville, Tenn. The company went to the trouble of setting it in the middle of a circle that Garrison explained was the circumference of a UH-60 Black Hawk's rotor.
Garrison stated with confidence that he was looking forward to the down select in the summer and talked about his expectation for the aircraft's development and performance. He said that the expectation was for the first flight to occur in 2017 and that the V-280 would easily achieve 280 knots, adding, "actually we will disappointed if it only goes 280 knots."
With the U.S. Army's benchmark for helicopter operating capability now set at 6,000 feet and 95 degrees F (known widely as 6K/95), Garrison said that whereas the V-22 was designed for 3K/95 – although the U.S. Marine Corps and U.S. Air Force have both operated their MV-22B/CV-22s in Afghanistan – the new Valor would be prepared for high/hot operations.
Talking about the investment into the JMR TD, Garrison revealed: "We invest around four dollars for every dollar the government invests." He said that he understood that the Department of Defense (DoD) was in "difficult position regarding their budget," but went on to say that he understood that the Science and Technology (S&T) dollars were being protected and that there was an understanding of the importance of JMR development to the future of Army Aviation.
"In JMR, industry's investment is significantly greater than the government's investment currently, so it is a great opportunity [for the DoD] to leverage the government's investment dollars with industry. Everything within DoD is a concern, but all indications are that they are fighting to protect the S&T."
But the V-280 is not just a smaller V-22, far from it. Says Garrison: "Much of the technology going into the V-280 is designed to attack cost and complexity. It is a more simple design than before – we have more modern tools today than we did when designing the Osprey. Survivability will be an important part of the aircraft."
But just as the V-22 relies on the attributes of speed and range, so will the V-280. "Think of what that means in terms of force structure and deploy-ability around the globe." He says it provides a strategic as well as tactical advantage.
One weak point of helicopter operations, particularly over a large area, is the requirement for Forward Aerial Refueling Points (FARPS), which help helicopters to operate away from their main base locations for long periods. However, those FARPS need to be constantly manned and resupplied with fuel, which actually is a significant draw on resources. As with the V-22, Garrison suggest, a V-280 would cut those back significantly.
Troy Gaffey has not named the AVX Aircraft offering – he says that is up to the Army to do. However, if he were to attach a name to it he said, perhaps tongue-in-cheek, he would call it the Warhorse.
When questioned as to why this young pretender of a company with around 25 engineers could displace the might of Bell or the Boeing/Sikorsky duo, he points to the fact that nobody on the Army's technical side has yet told him the company is too small to compete.
First, he points to the fact that within the AVX Aircraft team there is a wealth of experience and heritage gained working on the V-22 Osprey and the latest iterations of the H-1 family, the UH-1Y and the AH-1Z Super Cobra: "I was extensively involved as the technical director of the V-22; the guy designing our rotor system designed the V-22 rotor system; the guy who designed the V-22 main gear box is designing our drive system. The background is there and we are all familiar with working for a large company."
As Garrison did, Gaffey points to the value of teaming with the right people: "We have put together a team who are doing some experimental and production work on the rotor system together with Eagle Aviation Technologies."
He does not see the initial size of the company as a problem. "There is a big capability out there to build aircraft components. What we will most likely do is have a teaming arrangement with a company that can handle the assembly, integration and product support. We are talking to everybody, from helicopter manufacturers, fixed wing and military aerospace people."
The AVX Aircraft proposal is also a clean-sheet design, but Gaffey believes that it is one that combines the right amount of innovations with balanced, practical and tried solutions. "We know about trade-offs: power and weight, speed and range, and of guarding against cost escalation."
When discussing whether AVX will make the cut of "two from four" expected in the early summer, Gaffey said he believes that it will not be a black and white decision. The Army, he says, has given all of the contractors guidance on the process and to that, he believes, "the concept of down selecting two and the two others going away is probably not going to happen."
According to Gaffey, there are five potential scenarios with the two extreme options at either end unlikely to happen. That is, all four going ahead, or two being selected while the other two have nothing further to do with JMR.
The vulnerability is the realization that AVX is the only one of the four competitors that has not flown its own aircraft. Bell's tiltrotor pedigree speaks for itself; Boeing and Sikorsky have the X2 trials behind them and will fly the S-97 Raider (the aircraft that would have been presented to the Army for its now "on-hold" Armed Aerial Scout) by the end of the year; and Karem Aircraft founder Abe Karem designed and developed what eventually became Boeing's A160 Hummingbird, the first helicopter (unmanned) to use a variable speed rotor system.
But Gaffey remains optimistic that AVX will be involved in the JMR program beyond the official decision point "because of the technology that we are bringing to the party – we have a lot of ideas that are new and different."
The rotor blades on the AVX offering "are 20 percent lighter than you would predict; we have a unique design," he states. "Similarly on the fuselage, we are working very hard to get airframe costs down so we are using technologies different to the others. One example is that we are trying to minimize the number of fasteners being used, and that is where cracks to the airframe can start. To illustrate this point, around half of the six million parts used to fabricate a Boeing 747-800 commercial airliner are fasteners (see AviationPros.com, Sept. 22, 2011).
He also considers the design and performance to be crucial. A new design needs to be better than the existing fleet of Apaches and Black Hawks. "First, it provides much better cabin arrangements for the troops; there will be more and they will be heavier with more equipment."
Accordingly, the payload will be twice that of an existing Black Hawk, and it the aircraft will have double the combat radius. "Our dash speed will be 230 knots against the Black Hawk's dash of 150 knots. The cruise speed will be 180 knots versus 130 knots. Gaffey also plans for the aircraft to self deploy in line with the Army's requirement of reaching Hawaii from Travis Air Force base in California (a distance of around 2,300 miles). "Our aircraft can do that. We can put three ferry tanks into it, which will provide an additional 14,000 lbs of fuel to the internal tanks. We will also have a flight control system that allows it to fly unmanned, which has been a requirement for JMR. It takes 13 hours to get to Hawaii so we could potentially fly it unmanned all the way," he said.
If not directly selected this summer, Gaffey believes there could still be roles for all the competitors in helping the Army to understand how a JMR platform will develop into what it will require in a FVL platform but, he reaffirms, he still feels good about plan A.
Neither is AVX Aircraft a one-program company. Gaffey revealed that AVX is talking to the U.S. Navy about its future helicopter requirement, although this is not a program of record yet. "The U.S. Navy is interested in replacing its SH-60 Sea Hawks. If you look at the JMR, it isn't going to fit on a destroyer or a frigate and we have a smaller aircraft and an idea of how to fold one of these up that is rather interesting." It has been considered that any JMR aircraft – which then turns into FVL medium – would be a platform that not only the Army, but the Navy and the Air Force would use. However, neither of the other services have committed to the JMR program, so the future for a one-platform fits all helicopter remains gray at best.
There is also an opportunity to deliver an unmanned platform to the Navy. "We have submitted an RFP with another company (BAE Systems) for MRM UAS concept for the Navy. That involves a long-range ISR (intelligence, surveillance and reconnaissance) mission where a smaller aircraft could speed out to the orbit point then loiter with long endurance."
Back in 2010, AVX also responded to a U.S. Defense Advanced Research Projects Agency (DARPA) request that sought designs for a tactical fly/drive vehicle known as Transformer TX.
One of Gaffey's colleagues, Frank King, senior vice president of business development, summed up the AVX approach to progressing its business. "We don't bring with us either a legacy or burden of overhead that some of the bigger guys do. We applaud the Army in recognizing that innovation is not the birth rite of multinational corporations. We can bring innovation to the equation as well as utilize the capacity and skill that exists out there in the market. When it is time to gear up production facilities we have all the confidence in the world that we can partner with the folks who can deliver the scale of industry required."
Related: Airframe News


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VITC changeover unit and monitoring module.
- Download PDF
Module System Diagram
Module Control Panel
RUBIDIUM H1 SV module front view
RUBIDIUM H1 SV rear view
RUBIDIUM H3 SV rear view
- Switcher for VITC signals
- Signal monitor with status indicator
- GPI outputs for error indication
- Optional SNMP and status indication via an internet browser
- Bi-stable signal outputs relays
The PLURA "SV"module is an automatic switchover unit for VITC signals.
It monitors and analyzes two VITC sources. If a VITC source is lost, the VITC output is automatically switched to the other error free source.
Connected with a reference time source, the VITC signal is monitored and analysed in conjunction with this reference time signal.
The module can monitor the following:
- Errors in the VITC
- Errors in the reference time source,
- Time differences between the two individual VITC sources
- Status information of all input sources.
If an Ethernet module is present in the system, the status and error messages can be queried via a browser or SNMP.
When combined with two of PLURA master generators RUB "GT", a fully redundant fail-safe VITC generator system is possible.
One or both VITC input sources can be acquired from any third party devices as long as the VITC signal complies with the SMPTE/EBU specifications.
In the event of a failure the signals can be switched autmatically or manually. The changeover is completed with bistable relays.
The relay contact remains in its last position even if power is lost.
The relays are mounted on a separately installed circuit board, so that even when physically exchanging a module the signal flow can continue without interruption.
LEDs located on the front of the module indicate the operating status.
Built-in GPIs can be programmed to signal errors or other pre-programmed warnings.
The backlit keys on the front of the module can be programmed to suit the user specific needs (e.g. a key could be programmed to manually switch incoming sources).
Distribution amplifiers modules with four separate outputs as well as six fail-safe amplified outputs can be utilized for redundant systems.
The Rubidium series can offer various generators, inserters and converters for different signal formats (LTC, DVITC and ATC).
All programmable functions and the communication between modules can be set with the included configuration software.
The operating status of the module is available at any time via a status monitor function.
The status request is made using a PC software using the USB interface of the applicable housing (H1, H3, S1, T1).
Firmware upgdate for the frame and other modules can be set up via the same USB interface.
With the optional Ethernet module (RUB IE), Standard web browser can utilized for all status information and configuration menus.
Monitoring via SNMP is also possible.
Browser Configuration
Rubidium Configuration
DOWNLOADSData Sheet
Order Code
Product Model ID: RUB SV Module description VITC change-over and monitoring unit RUBIDIUM series 1 & 3 Change-over Module


text: Baba Nyonya Heritage Museum ADD TO TRIP PLANNER REMOVE FROM TRIP PLANNER The 'Straits Chinese', also called the Baba and Nyonya, are Chinese of noble descent who have adopted much of the Malay culture into theirs. This has been a gradual process lasting over 400 years since the great Chinese explorer Admiral Cheng Ho first brought Chinese settlers to Melaka. Over the centuries, the Baba Nyonya have developed a distinct and highly interesting culture that is unique to Malaysia's west coast, particularly Melaka. The public can now view the historical artefacts unique to this heritage at a captivating private museum run by the Babas and Nyonyas of Melaka. Within the walls of this heritage building, you can learn everything there is to know about this unique culture. The Heritage Museum offers guided tours (by appointment), research facilities and audio visuals. Well worth a visit! Getting Here By Foot or TaxiThe museum is on Heeren Street, parallel to Jonker Street. Who To Contact The Baba Nyonya Heritage Museum Phone: +606 - 283 1273 Tourism Malaysia Melaka Office Phone: +606-288 3304/ 3785 Related Brochure View all brochure


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HP Deskjet Ink Advantage 2676 Driver and Software for Windows, Mac Os, and Linux – Many of you will surely have understood that you need to install the proper printer driver before you start using a printer. If you have lost the CD to install the driver, you can download it from the internet. For those who are using HP Deskjet Ink Advantage 2676 printer, you have to make sure that you are installing the compatible driver based on your PC specification.There is nothing that you need to worry about if you are looking for the website to download the printer driver that you need. There are quite a lot of websites that will give you the download link to download the driver for the HP Deskjet Ink Advantage 2676 printer. You just need to make sure that you get the right version of the printer driver.
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Release date: Sep 24, 2018
Filename: HP_Easy_Start.app.zip
File Size: (9.1 MB)
Installation Process
You can follow these instructions to install the downloaded driver.
- Find the setup file that you have just downloaded. You can check the location from the download folder from your current browser. Most of the time, the setup file will have the .exe extension.
- Run the driver that you have just installed. For this one, make sure you run the setup file as the administrator. This one is meant to make sure that nothing will go wrong during the installation process of the driver of HP Deskjet Ink Advantage 2676 All-in-One printer.
- Follow all of the simple instructions on the installation wizard. This is not something hard to do because you just need to follow the simple instructions there. After that, the installation process will start automatically.
Recommended Installation
- This kind of installation is something that many people choose because this installation type is considered as the simplest one of all. As an addition to that, you can also get the best features based on the kind of printer that you have as well as the performance of your computer.
Custom Installation
- Custom installation is meant for those who want to have the compact installation for the HP Deskjet Ink Advantage 2676 All-in-One printer. This one is usually sued by those who have the low specs computer. The point that you need to highlight is that you need to understand all of the components on the installation. Or else, you might not be able to use the driver after the installation.


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The Oakland social- and environmental-justice activist and author who went to Washington last year as President Barack Obama's "green jobs czar" — only to be let go in the face of conservative criticism — has joined a White House-friendly think tank in a similar capacity.
Van Jones, 41, will serve at the Center for American Progress, or CAP, as a senior fellow to lead its new Green Opportunity Initiative. He also has been appointed distinguished visiting fellow in the Center for African American Studies and in the Program in Science, Technology and Environmental Policy at Princeton University's Woodrow Wilson School of Public and International Affairs.
"We are thrilled that Van Jones is joining us to spearhead a 'green opportunity' agenda to develop the policies and strategies that will ensure the clean-energy future brings not just climate stability and energy security, but also broadly shared economic prosperity," Kate Gordon, CAP's vice president for energy policy, said in a news release Wednesday.
Jones will work with CAP's existing Energy Opportunity team to develop an agenda for expanding investment, innovation and opportunity through clean energy and environmental restoration — especially for low-income and minority communities. That essentially was his job description as founder of the Oakland-based nonprofit Green For All; as author of the 2008 New York Times bestseller "The Green Collar Economy;" and as special adviser for green jobs at the White House Council on Environmental Quality from March through September.
John Podesta, CAP's president and CEO, called Jones "a pioneer in the effort to promote a clean, sustainable economy that works for all Americans. I'm proud that he's coming back to CAP to focus on creating economic opportunity in distressed communities through the Green Opportunity Initiative and that he will be giving voice to those issues once again."
Jones resigned his White House post after conservatives targeted him for past political activities, including his 1990s association with a Marxist group and a public comment disparaging congressional Republicans. In his first interview since his resignation, Jones told The Washington Post on Tuesday he has no "bitterness or anger" about what transpired last year.
"The good thing about being an American is you're free to think whatever you want, and you're also free to change your mind. That's my story. … God willing, I've got 10 or 20 years, 30 years, three decades more work to do. And it's my hope and belief that people will judge me based on that work."
In a column published Wednesday on the Huffington Post, National Association for the Advancement of Colored People President Benjamin Jealous — a former Alameda resident — wrote that he is proud to be presenting Jones with the group's President's Award on Friday at its' 41st Image Awards.
"Far from the divisive caricature painted by some cable news outlets, Van has been one of America's most effective and inspiring bridge-builders," Jealous wrote. "He has successfully brought together labor leaders, business executives, civil rights champions, students and environmentalists to find creative solutions to the ecological and economic crises."
CAP was launched in 2003 and has been supported since with funding from East Bay billionaire banking moguls Herb and Marion Sandler, and has had close ties to the Obama administration. Podesta, a former chief of staff to President Bill Clinton, went on leave from the center for a while to serve as one of three co-chairs of Obama's transition team; several fellows and trustees were appointed to administration posts; and CAP consistently has helped shape the message on such administration initiatives as health care reform, economic stimulus and national security.
Read the Political Blotter at www.ibabuzz.com/politics.


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Larry Jones (born September 22, 1942 in Columbus, Ohio) is a retired American basketball player. He played professionally in the NBA and ABA, from 1964 to 1974.
A 6'3" guard from the University of Toledo, Jones started and ended his career with the NBA's Philadelphia 76ers, who drafted him in 1964. However, Jones would have his best years in the rival ABA, playing for the Denver Rockets, The Floridians, the Dallas Chaparrals, and the Utah Stars from 1967 to 1973. A high-scoring jump shooter, he averaged at least 22 points per game during each of his first four seasons in the league, and during one stretch with the Rockets in 1968, he scored at least 30 points in 23 consecutive games. He was also named to four ABA All-Star teams, and he was the first president of the ABA Player's Association. Upon retiring from professional basketball in 1974, Jones had tallied 10,505 combined NBA/ABA career points. Larry is now a substitute teacher in Columbus City Schools.


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Aktiv is a new sporty and playful rubber boot created for active kids. The outsole is sturdy and gives the kids a good grip. Aktiv comes in many color combinations - a must have for active kids in rainy weather.
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Feb 01, 2012
Centerville, Mass. - Junior forward AJ Matthews (Brooklyn, N.Y.) was named ECAC Division III Metro Player of the Week on January 31st, 2012.
Matthews, the recipient of this week's Skyline Conference award, led the Rams to league wins over Old Westbury in overtime (71-70) and Mount Saint Mary (76-55). In the first outing, he had 22 points and 19 rebounds. Against Mount Saint Mary, he posted 22 points and 23 rebounds (school-record) to go along with a school-record nine blocked shots. He leads the nation in rebounding average at 15.6 rpg.


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Police say 'suspicious' man who approached child was in fact a friend
New London — The "suspicious man" who police said approached a school-aged child who had missed the bus Thursday morning turned out to be a family friend, police say.
Police said earlier a caller reported that a child who had missed the school bus had been approached near Montauk Avenue and Lower Boulevard by a man who made comments and followed the child a short distance.
On Friday afternoon, New London police said in a statement that through investigation they have confirmed the child was actually approached by a family friend. The witness who overheard an exchange between the child and man thought the incident seemed suspicious and rightfully reported it to police, said Deputy Police Chief Peter Reichard.
Reichard said similar incidents were reported on the morning of Sept. 9 on Montauk Avenue near Mitchell Court and on the afternoon of Sept. 16 in the Lower Boulevard area. Those incidents remain part of active investigations. Police have increased patrols during school bus pick up and drop off times.
Police are asking residents to continue to be aware of their surroundings and remind children about safety.
Police suggest that parents remind their children:
- Never respond to strangers when alone.
- Stay with your friends.
- Report suspicious incidents to trusted adults.
- Never accept gifts, food or candy.
- Never accept rides.
- Be alert to similar incidents, especially in areas that have been identified.
- Never go with anyone without a parent's or guardian's permission.
- Always tell someone where you are going.
Reichard said police encourage citizens always to report suspicious activity and thank the citizens who conveyed the suspicious activity that they had witnessed.
If anyone has information regarding such activity, they are asked to contact the New London Police Department. In an emergency, call 911. For non-emergencies, please call (860) 447-5269.
Stories that may interest you
Police: Driver taken to hospital after having medical emergency in Norwich
A driver was taken to the hospital under life-threatening conditions after witnesses observed him apparently having a medical emergency and hitting a school bus and other vehicles, police said.
Sister receives deal from state, testifies about Griswold triple murder
Ruth Correa described the murders of Matthew, Janet and Kenneth Lindquist in excruciating detail, then admitted she had lied about some of the information during interviews with police.
Intense fire the focus as hearing gets underway in Griswold triple murder case
The intense 2017 fire that consumed the Lindquist family home in Griswold was the focus of testimony Monday as a probable cause hearing began in the case of Sergio Correa.
Democratic hopefuls call for Kavanaugh's impeachment after new allegation


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Researchers@Work: Energetic Material Research
March 20, 2014
Dr. Betsy Rice, ARL Fellow, discusses how the Army Research Laboratory's history in modeling and simulation in dynamic responsive materials is helping to develop warfighter solutions designed to address evolving threats. In this latest video, she imagines a future weapon system that would allow a Soldier to use a single weapon that has firepower that can be 'dialed up or down' to stop a sniper or a blow open a cave from several miles away.
(Produced by T'Jae Gibson. Edited by Larry Shank and Brett Wright)


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Denali National Park, Autumn 2013
One of my favorite places on Earth. Beautiful in any season, but especially so in autumn, when the tundra becomes a vast carpet of brilliant fall colors. Blueberries are everywhere! It is not uncommon to see a grizzly bear (or a human) standing in the middle of a field eating berries by the paw full. The animals; grizzlies, caribou, moose, fox, coyote, wolf, ptarmigan, loons & magpies, seem so completely at ease here. At home on this landscape as they have been for centuries.Read More


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October 2016
|<< September 2016
|November 2016 >>
|Oct 19, Wed
|Days of Caring, Edu Annex Classroom 3
| 8:00am - 12:00pm
The Desert Museum is hosting several service projects in conjunction with United Way's "Days of Caring" events. Volunteer have the choice of assisting the Conservation, Education & Science Department with a Buffelgrass Pull or assisting the Exhibit's Department with sanding and oiling the Coati Club Field Station.
|<< September 2016
|November 2016 >>
View by Day | View by Week (Calendar) | View by Week (List) | View by Month (Calendar) | View by Month (List) | View by Year (Calendar) | View by Year (List)


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skullman80 wrote:Kovy27 wrote:Spangler wrote:Ziggler needs to work on his tan lines...
Rock beats CM Punk at Rumble.
Shield attacks Rock.
Ziggler cashes in and wins.
I know it's stupid, but Ziggler's MITB briefcase is only for the World Heavyweight Title, not the WWE title. So he can't cash in, in that scenario.
Son of a...I forgot that Cena had the other one. Fudge. Ruins that idea.


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V Engine is a modern 3d engine which simplifies the creation of virtual three-dimensional worlds. Engine provides many advanced graphics technologies: HDR rendering, FFT water, atmospheric scattering, post-effects, soft particles, GPU skinned animation, lightmaps, parallax, normal and specular mapping, anaglyph stereo 3d, GUI (Unicode, TTF, Ogg Theora are supported), sound (OpenAL), script system (Lua), network, WYSIWYG editor etc.
Only registered members can share their thoughts. So come on! Join the community today (totally free - or sign in with your social account on the right) and join in the conversation.


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- Auteur(s):
- Verhey, Luc; Kiiver, Philipp; Loeffen , Sandor
- Jaartal:
- 2009
- Taal:
- engels
- Afmetingen:
- 16x24 cm
- Pagina's:
- 171
- 9789089520555
- Uitvoering:
- Paperback
- Druk/editie:
- First
Europa Law Publishing
Political Accountability and European IntegrationTerug
This volume addresses the future of political control and accountability in a European and comparative perspective. It is based on the contributions to an international conference hosted by the Montesquieu Institute (Centre of European Parliamentary History and Constitutional Development) at Maastricht in March 2008. The conference concluded a larger research project that was devoted to identifying features of domestic constitutional law that could help develop a system of effective accountability for the European Union. This volume contains contributions from Thomas Christiansen, Paul Craig, Deirdre Curtin, Bruno de Witte, Philipp Kiiver, Veith Mehde, Dawn Oliver, Jit Peters, Michael Shackleton, Jan Jacob van Dijk, Walter van Gerven, Luc Verhey and Anchrit Wille.


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This is a tutorial about Tsuna from Kateikyou Hitman Reborn! It took me some time to draw it but I hope you'll like it :)
DragoArt members upload artwork and drawing tutorials! They are also allowed to leave comments on tutorials, profiles, etc. Many more features, as well; it's way better than just being a boring guest! Register Now!


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Yesterday CNBC was kind enough to have me on to talk about Apple's reported plans to release an iPad-mini.
It ended up being a debate between myself and the other guest, Todd Schoenberger of Blackbay Group. He thinks Apple is making a mistake because it's chasing the smaller tablet market instead of defining it, and he thinks Apple will have its margins squeezed.
I think both of those arguments are ridiculous. Apple has defined the tablet market. It is not chasing after Amazon or Google. Neither company has sold a tablet in comparable amounts to the iPad. Apple is simply expanding its market. This is a natural evolution of the iPad.
As for margins, Apple, and Tim Cook in particular, won't sell a product that doesn't make money. If the margins are squeezed a little, then so be it. However, I think Cook, with his understanding of the supply chain will be able to make plenty of money on a smaller iPad.
Here's the full video of our debate:


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Leialoha Borja is Guam's Finest and Our Babe of the Day
Leialoha Borja was born and raised in Guam, and she currently models in the unincorporated U.S. territory. The exotic babe is just 19 years-old, but she has already racked up a series of shoots.
Leialoha specifically wants to take part in fashion shows, street wear, catalog, art and even go-go dancing gigs.
The burgeoning model isn't particularly active in social media, but her photos are still certainly worth ogling.


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VA State Police Collected Massive Amounts Of License Plate Data By Scanning Plates At Political Rallies
from the a-complete-disdain-for-the-public dept
There are many legitimate uses for license plate data -- tracking auto theft or vehicles used in the commission of crimes. Collection of plate and location data by automatic license plate readers can be troublesome in terms of privacy, but this can usually be mitigated by the prompt disposal of data unrelated to criminal activity. Unfortunately, many states are operating license plate readers without privacy safeguards in place, or are simply building massive databases with no disposal plans for "non-hit" plate data.
Over in Virginia, state police are doing everything wrong when it comes to responsibly deploying automatic license plate readers. It's grabbing massive amounts of license plate and location data, holding onto the info for multiple years, and targeting drivers engaged in First Amendment-protected activity.
From 2010 until last spring, the Virginia State Police (VSP) maintained a massive database of license plates that allowed them to pinpoint the locations of millions of cars on particular dates and times. Even more disturbing, the agency used automatic license plate readers (ALPRs) to collect information about political activities of law-abiding people. The VSP recorded the license plates of vehicles attending President Obama's 2009 inauguration, as well as campaign rallies for Obama and vice presidential candidate Sarah Palin...The chilling effects of the state's activity are obvious.
[B]y creating and maintaining a database of millions of license plates and targeting political activity, the VSP crossed well over the line from legitimate law enforcement to oppressive surveillance. In the cases of the campaign rallies and the 2009 inauguration, the VSP collected personally identifying information on drivers solely because those drivers were heading to a political event. These drivers were not suspected of or connected to any crime — their only offense was practicing their First Amendment rights to speak freely and assemble peacefully.This wasn't just a local operation. Documents obtained by the ACLU via a FOIA request show the Virginia state police operated in conjunction with the FBI to utilize its database to search for "hits" against the state's collected license plate data.
Also included in the documents are two promotional slideshows from ELSAG, the license plate reader supplier. These detail the many advantages of its system, including inputs for facial recognition cameras. When not putting suspended/uninsured drivers into the same list of criminals as the DC snipers and human traffickers, the slideshow is bragging about how many records it's able to collect and retain (50 million in NYC alone without losing a single record!). It also details the exploits of Arizona DPS officer David "Army of ONE" Callister, who was able to rack up 1.1 million "reads" in 16 months.
Unsurprisingly, there's not a single slide in the deck that deals with privacy concerns or the disposal of "non-hit" data. The second deck goes even further, encouraging LEOs to "drive up the numbers" (rack up as many hits as possible). It states: "Read 1000 tags, get a stolen, read 6,000 get an arrest." Does anyone other than ELSAG and law enforcement officers like those odds?
Now, were Virginia police looking to hassle politically-minded citizens? Probably not. Targeting both sides of the political aisle indicates the department's intention wasn't necessarily to chill free speech. This looks more like a crime of opportunity. Thousands of cars headed to (or parked at) single locations was simply too much data to pass up. But the underlying effect remains: even if this wasn't politically motivated, the state police have the technology in place to target any gathering it finds undesirable.
Although it comes far too late to head off the state's collection endeavors, the State Attorney has issued a statement condemning this use of LPRs.
In a strong opinion, Cuccinelli explained that the use of ALPRs for "passive" collection of information violates Virginia's Government Data Collection and Dissemination Act. That is, law enforcement may use ALPRs to search for specific vehicles suspected of involvement in criminal activity, but it may not simply collect and save data on thousands of vehicles for which there is no grounds for suspicion.This statement runs directly contrary to the selling points of the LPRs, at least according to ELSAG. In its pitch, more scans equals more hits, and that's all the justification most officers are going to need. This isn't targeted technology. This is mass scanning hardware that relies on thousands of reads in order to land a direct hit, and it's backed by a company that brags about a single officer racking up over a million scans on his own. These two viewpoints clash badly, and as strongly as the AG feels about this, he's got an uphill battle against law enforcement and the camera company itself if he's going to effect any change in this mindset.
Of course, now that it's been caught holding onto all of this data for nearly three years, the state police has finally purged its database of non-hit plate data and will be disposing of unrelated data within 24 hours going forward. But the fact is that these policies should have been in place before the PD deployed the cameras. This incident does very little to alleviate fears of future abuses. Like our nation's intelligence agencies, the standard MO for deployment of law enforcement technology is to exploit the system until caught and forced to operate within belatedly-applied confines.
Filed Under: license plate, license plate scanning, police, virginia


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The Zealous Crew Roster is brought to the crew in order to make it easier for each member to know who is in what department and to make interaction less confusing. If there are any errors in the Roster please alert Captain Azanialix Ja'arda, Jake Sjet, or Alex Ducane. The Roster will be sent out every week (Saturday) in order to keep everyone up to date.
Promotions are a reflection of logs and mailstring activity. The following is a GUIDELINE towards promotion but is not the final tool used in decisions. Remember, if you wish to be promoted, or to someday become a sim host, activity is the only way to achieve this. We will give out promotions following every mission, some will be at a party while others will probably be less formal.
Commissioned Officer Ranks:
Ensign – No requirement, beginning position
Lieutenant Junior Grade – 1 bio and 10 logs
Lieutenant – 1 bio update and 20 logs (after promotion)
Lieutenant First Class - an additional bio update and 25 logs (after promotion) and recommendation of XO or CO
Lieutenant Commander - an additional bio update and 30 logs (after promotion) and recommendation of XO and CO
*Non-Commissioned Officer
Petty Officer 3rd Class – No requirement, beginning position
Petty Officer 2nd Class – 1 bio and 10 logs
Petty Officer 1st Class – 1 bio update and 20 logs (after promotion)
Chief Petty Officer - an additional bio update and 25 logs (after promotion) and recommendation of XO or CO
Senior Chief Petty Officer - an additional bio update and 30 logs (after promotion) and recommendation of XO and CO
* = If so desired, NCOs may elect to take a Starfleet exam.
If they pass, they will become a Commissioned Officer.
Remember, we do ask at least one log a week from everyone (barring LOA or such).
Important Note: Due to continuing mailstring and forum problems, if you posted a log and did not see it reflected accurately within the roster, please let me know! I will get it remedied for the next roster update.
There were no removals this week, and nobody is On Warning. Now that the server move is finished, the reprieve that we've given everyone is over! As such, we now have THREE people On Notice! Remember, if you are On Notice or On Warning, make sure you get a log in so you don't face removal!
Posters this week:
Sernia, Zuub, Beatrix, Lester, Joy, Aspera, Byrn, Yunisca, Lucas, Sjet, Zania, Garbing, Alex, Ti'ana, Murdock, And Bradhurst
The SLA forums are back up and running! You can access them by going to
_http://tenforward.slasims.com_ (http://tenforward.slasims.com/) .
Please remember to keep our back-up forums
Also, please remember to post your logs both on the forums, in the Current Log Thread, and to send them to the mailstrings. I'm having difficulty with getting some e-mails through the mailstrings. Cross posting is the best way to insure that your logs will be counted!
Now that we also have our mailstrings back as well, let's see if we can get the activity to pick up again!
If your name is in red that means that you are in risk of being removed from the sim due to inactivity. We will need a log from you within one week's time in order to keep you on the sim.
If your name is blue that means that you are at risk of being declared On Warning within one week, and this could be moved to Removal if a log is not sent out within two weeks. Please remember to write at least one log a week. After all, if you are not writing how can you enjoy the sim?
If you need a LOA (Leave of Absence) simply let us know and we can help you.
If you have questions or need help, just let us know. We are there to help you.
We will be putting crew in the On Warning status after 3 weeks without activity and removing crew members after 4 weeks without activity. We're not trying to ride anyone, and this is all supposed to be fun, but if you're not posting at all it's no fun for you.
With the exception of Department Heads, crew members on Extended LOA (3 weeks or more), will no longer be listed in the primary crew roster.
Instead, they will be listed on an ELOA Crew Roster, which can be found at:
(http://tenforward.slasims.com/viewtopic.php?t=9098) .
Upon their return, their character will again be listed on the primary roster.
Position – Rank/Name (Logs since promotion)
Command Staff
Commanding Officer – Captain Azanialix Ja'arda (311)
Executive Officer – Commander Alex Ducane (28)
Bridge Officers
Chief Helm Officer--Lt Cmdr. Howard Madej Murdock (196)
Ensign Sernia Soban (30)
Ensign Ripley Stargrazer (NPC)
Chief of Operations - Lt Cmdr. Ti'ana Sullivan (38)
Assistant Chief of Operations - Lt. 2C Jake Spade (46)
Lt. JG Anthony Ross (2)
Engineering Department
Chief of Engineering – Lt. 1C Vaskel (15
Lt. JG Ma'riel Gine (NPC)
Lt. JG Alexander Thomas (12)
Ensign Jason Hawk (8)
Ensign Samantha Baines (NPC)
Science Department
Chief Science Officer – Lt Cmdr. Joy Robinson (36)
Assistant Chief Science Officer - Lt. 1C Jarrold Scott (65)
Lt. Karen Stanton (NPC)
Medical Department
Chief Medical Officer - Commander Alex Ducane (6)
Assistant Chief Medical Officer - Lt. 2C Zuub (28)
Ensign Kiara Burns-(2)
EMH Mark II (NPC)
Counseling Department
Chief Counselor - Lt Cmdr. Melissa Richards (24)
Ensign Lester Combs-(14)
Ensign Beatrix Aster-(11)
Ensign Yunisca-(3)
Chief Tactical Officer – Lt Cmdr. Luke Osswell (26)
Ensign Jack Rally (9)
Lt. Devin Nord (NPC)
Ensign Roger Xavier Bradhurst-(3)
Lt. JG Teresa Gomez (NPC)
Chief Security Officer - Lt. 2C Daniel Hunt (19)
Ensign Taryn Ryder (6)
Ensign Jason Garbing (35)
Ensign Nikolai Varnyenko-(1)
Ensign Sara McGonaggle (NPC)
Chief Intelligence Officer - To Be Announced
Assistant Chief Intelligence Officer - Lt. JG James Black (NOP)
Ensign Bryn Kincaid-(5)
Cook - Vin'Ti (NPC)
Lounge Manager - Aurianne Hope Tailae Kaemada Siersou/Xternal aka Quamada (67)
Lt. Cmdr. (Retired) Jake Sjet (300)
Artificial Intelligence-Aspera (1)
Command Staff
USS Zealous
"Pugio in Averso Belli- Weapon used to avoid war"


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shmenguin wrote:Gaucho wrote:As I've stated before, what I like about Bennett is that he can play in a Top 6 role, but he's also savvy and good enough to play on the 3rd line. In fact, I think I'd rather have him on Sutter's wing for now.
i don't think him skating around by himself in the offensive zone is the best way to cultivate his talents. sutter doesn't play nice with his linemates. stick someone more resilient with him - not a guy who still needs a little coddling.
There is no evidence that Sutter doesn't ever play nice with his linemates, he just doesn't play well with Cooke, Kennedy and Glass. Too small of a sample size.


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17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00088374
Recruitment Status : Completed
First Posted : July 26, 2004
Results First Posted : September 29, 2011
Last Update Posted : July 27, 2012
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study will examine whether the drug 17AAG (17-allylamino 17-demethoxygeldanamycin) can shrink kidney tumors in patients with Von Hippel-Lindau disease (VHL), a rare, inherited syndrome in which patients develop tumors in certain parts of the body. 17AAG contributes to the destruction of proteins in cells that may play in role in causing cancer and spurring tumor growth. The study will also look at the effect of 17AAG on other tumors patients may have that are caused by VHL, on the amount of blood vessels in the tumors, on the biologic activity of the tumor, and on cells circulating in the bloodstream, as well as the safety of the drug and its impact on the kidney tumor in patients whose tumor(s) is removed.
Patients 18 years of age and older with von Hippel-Lindau disease who have at least one kidney tumor large enough to pose a risk of metastasis (spread of cancer to other parts of the body) may be eligible for this study. Candidates are screened with a medical history and physical examination, computed tomography (CT) scan, brain magnetic resonance imaging (MRI), see below), and blood and urine tests. Additional tests, including a 24-hour urine collection, ultrasound of the testicles in men, hearing test, eye exam, and MRI of the spine, may be done if recent test results are not available.
Participants undergo the following tests and procedures:
MRI: This test uses a strong magnetic field and radio waves to show structural and chemical changes in tissue. During the scan, the patient lies on a table in a narrow cylinder containing a magnetic field, wearing earplugs to muffle loud noises that occur with electrical switching of the magnetic fields. A catheter (plastic tube) is inserted into the patient's arm to administer a contrast dye that enhances the images.
17AAG treatment: Patients receive 17AAG infusions into a vein once a week for 3 weeks out of every 4, for 3 months. The infusions last up to 1 to 2 hours.
Repeat testing: After 3 months, patients have repeat MRI scans to measure changes in tumor activity, blood flow, and number of blood vessels in the tumor since the pretreatment scans. They may have additional tests, including a CT scan, eye exam, and other tests to evaluate the effect of 17AAG on the tumors.
|Condition or disease
|Hippel-Lindau Disease Kidney Cancer
|Drug: 17 allylamino-17-demethoxygeldanamycin Drug: 18 FDG (Fludeoxyglucose 18F) Drug: [15-O] H2O Drug: EPL diluent
|Phase 2
Von Hippel-Lindau disease is a hereditary cancer syndrome in which affected individuals are at risk for developing tumors in a number of organs, including the brain, spine, adrenal glands, eyes and pancreas.
The molecular hallmark of VHL is inactivation of the VHL gene which leads to accumulation of the hypoxia inducible factors (HIF); this, in turn results in overexpression of several genes including vascular endothelial growth factor (VEGF), glucose transporter 1 (GLUT-1), transforming growth factor alpha (TGF-α), platelet-derived growth factor (PDGF) and erythropoietin, which play an important role in tumorigenesis, tumor growth and metastasis.
17-allylamino-17-demethoxygeldanamycin (17AAG) is an inhibitor of the cellular chaperone heat shock protein 90 (Hsp90), and its interaction with Hsp90 leads to destabilization and degradation of several proteins, that depend on Hsp90 for their stability.
The alpha subunit of HIF1 is one such Hsp90 client protein' and is susceptible to VHL independent, 17AAG-induced degradation.
To evaluate the efficacy of 17 AAG administered as a single agent in von Hippel Lindau patients with renal tumors. The primary endpoint of the trial is response of renal tumors following 3 cycles of therapy.
To study the safety and tolerability of 17 AAG. To evaluate PD modulation of hsp90, and to explore the utility dynamic contrast enhanced MRI in evaluation of blood flow and metabolic changes in renal tumors before and during therapy
Adults with clinical diagnosis of von Hippel Lindau disease Presence of one or more localized renal tumors for which surgical resection would be considered the standard approach
Patients will receive 17 AAG as an intravenous infusion at a dose of 300mg/m(2) on days 1, 8, and 15 of 28 day cycles.
The study will follow a two-stage MinMax phase II design and will accrue a maximum of 26 patients.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|9 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase II Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Von Hippel Lindau Disease and Renal Tumors
|Study Start Date :
|July 2004
|Actual Primary Completion Date :
|January 2009
|Actual Study Completion Date :
|January 2009
|Experimental: Von Hippel-Lindau (VHL) associated renal tumors
Drug: 17 allylamino-17-demethoxygeldanamycin
17 allylamino-17-demethoxygeldanamycin (17 AAG) given intravenously at a dose of 300 mg/m2 on days 1,8 and 15 of 28 day cycles.
Other Name: 17 AAG
Drug: 18 FDG (Fludeoxyglucose 18F)
18FDG PET performed at baseline and 12 weeks after treatment. At each timepoint participants can receive 250mCi 0-15 water and 15 mCi F18-FDG.
Other Name: Fludeoxyglucose (18F)
Drug: [15-O] H2O
[15-0] H20 performed at baseline and 12 weeks after treatment. At each time point participants can receive 250mCi 0-15 water and 15 mCi F18-FDG. The water scans were done as several intravenous injections for several scans but not over a total of 250 mCi.
Other Name: water scan
Drug: EPL diluent
17AAG is formulated with this diluent. Supplied in a 50 mL flint vial containing 48 mL of 2% egg phospholipids, and 5% dextrose in Water for Injection, USP. Patients with a history of serious allergic reactions to eggs should not receive this agent.
Other Name: Egg phospholipid
- Number of Participants With a Renal Tumor Response [ Time Frame: 12 weeks ]Response is defined as the number of patients who experience a disease response (complete response (CR) or partial response (PR) of renal tumors)per RECIST criteria. CR is the disappearance of all target lesions. PR is at least a 20% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum LD. See the protocol Link module for the full criteria if desired.
- Number of Participants With a Non-renal Tumor Response [ Time Frame: Baseline and 12 weeks ]Number of patients who have a PR or CR of non-renal lesions (pancreatic tumors, pheochromocytomas, and hemangioblastomas). The effect of treatment on the lesions will be evaluated at baseline and at the time of restaging (12 weeks) per RECIST criteria. RECIST is defined as changes in only the largest diameter (unidimensional measurement) of the tumor lesions. Lesions are either measurable or non-measurable using the criteria. See the protocol Link module for the full criteria if desired.
- The Number of Participants With Adverse Events [ Time Frame: 1 yr, 364 days ]
Here are the total number of participants with adverse events. For the detailed list of adverse events see the adverse event module.
The descriptions and grading scales found in the revised NCI Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 will be utilized for adverse event reporting. For a detailed description see the link in the Protocol Link module.
- The Number of Participants With HIF, HSP90, and HSP70 Modulation in Resected Tumor Tissue and/or Peripheral Blood Lymphocytes [ Time Frame: Baseline and 12 weeks ]Measurement of HIF, HSP90 and HSP70 levels by Western Blot in tumor tissue and/or lymphocytes to assess modulation of these biomarkers in response to 17 AAG treatment. Pretreatment tumor samples (when available) and resected tumors (in those patients who did not have a response and underwent surgical resection of their tumor) were to be used for this analysis. Levels of Hsp90, Hsp70, HIF and HIF transcriptional targets in resected tumor will be compared to respective levels in tumors previously resected from other VHL patients (not treated with 17AAG).
- Number of Patients in Whom Renal Tumors Could be Identified by Positron Emission Tomography (PET)Based on Fludeoxyglucose 18F (18FDG) Uptake [ Time Frame: Baseline and at 12 weeks ]Images were acquired after the intravenous administration of 18FDG and H2015 and used to analyze glucose uptake and estimate blood flow. The parameter to be measured is SUV (standard uptake value(s)) and/or mL/min/gm.
- Number of Participants With Flow Dynamics Measured by DCE MRI Within the Renal and Non-renal Tumor [ Time Frame: Baseline and during therapy (12 weeks) ]Dynamic images will be acquired before and after the intravenous administration of 0.1 mmol/kg of Gadolinium Diethylene triamine pentaacetic acid (DTPA). Time activity curves will be generated over a period of ten minutes. The parameter to be measured is the forward contrast transfer rate (Ktrans), the reverse contrast transfer rate (Kep), and/or the extravascular extracellular space volume fraction (Ve). Flow dynamics are a measure of blood flow changes in the tumor and are determined using the parameters we had previously defined (Ktrans, Kep, etc.).
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients must satisfy all of the following inclusion criteria to be eligible for study enrollment.
- Clinical diagnosis of von Hippel Lindau disease.
- Presence of one or more localized renal tumors for which surgical resection would be considered the standard approach.
- Age greater than or equal to 18 years. Because no dosing or adverse event data are currently available on the use of 17 AAG in patients less than 18 years of age, children are excluded from this study.
- Life expectancy less than 3 months.
- Performance status Eastern Cooperative Oncology Group (ECOG) 0-2.
- Patients must have normal organ and marrow function as defined below: white blood cells (WBC)count greater than or equal to 3,000/microliter, absolute neutrophil count greater than or equal to 1,500/microliter, platelet count greater than or equal to 100,000/microliter, Hgb greater than 10Gm/dl, serum creatinine less than or equal to 1.0 upper limit of normal (ULN) or measured 24 hour creatinine clearance greater than 60 ml/min,aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 1.0 times the ULN, total bilirubin less than or equal to ULN(less than 3 times the normal limit (NL) in patients with Gilbert's disease).
- Negative hepatitis B surface antigen (HbsAg), human immunodeficiency virus type 1 (HIV-1) and nonreactive hepatitis C virus (HCV).
- No history of serious intercurrent illness.
- At least four weeks from completion of any surgical or investigational therapy for von Hippel Lindau disease.
- Willingness to undergo resection of renal tumor at the time point defined in the protocol.
- All men and women of childbearing potential must use effective contraception as determined by the principal investigator or protocol chair.
- Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
- Prior or concomitant non-von Hippel Lindau associated malignancy with the exception of adequately treated basal or squamous cell carcinoma of the skin or any other malignancy from which the patient has remained disease free for more than five years.
- Any renal tumor greater than 4cm in size.
- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events (to grade 1 or less toxicity according to Common Terminology Criteria for Adverse Events version 3.0 (CTCAE 3.0) due to agents administered more than 4 weeks earlier.
- Patients may not be receiving any other investigational agents.
- Patients with known metastatic renal cell cancer.
- Patients with a history of serious allergy to eggs.
- Concomitant therapy with cytochrome P450 3A4 (CYP3A4) potent inhibitors.
- Patients who are on CYP3A4 substrates and inducers qualify for enrollment for this study.
- Pregnant women are excluded from this study because 17 AAG has the potential for teratogenic or abortifacient effects, and no data regarding its safety in pregnant women is available. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with 17 AAG, breastfeeding should be discontinued if the mother is treated with 17 AAG.
- Human immunodeficiency virus (HIV)-positive patients are excluded from the study because of unknown but potential pharmacokinetic interactions of anti-retroviral drugs with 17 AAG.
- Use of any medications that prolong or may prolong corrected QT interval (QTc).
- Patients who have significant cardiac disease including heart failure that meets New York Heart Association (NYHA)class III and IV definitions, uncontrolled dysrhythmias requiring anti-arhythmic drugs, or patients with active ischemic heart disease including myocardial infarction and poorly controlled angina within 12 months of study entry.
- Patients who have a history of serious ventricular arrhythmia (ventricular tachycardia (VT) or ventricular fibrillation (VF),greater than or equal to 3 beats in a row), QTc greater than or equal to 450msec for men and 470msec for women, or left ventricular ejection fraction (LVEF) below lower limit of normal by multi gated acquisition scan(MUGA).
- Patients with a history of prior chest radiation or radiation that potentially included the heart in the treatment field.
- Patients with congenital long Q wave, T wave (QT) syndrome.
- Patients with left bundle branch block.
- Patients with symptomatic pulmonary disease requiring medication, including the following:dyspnea, dyspnea on exertion, paroxysmal nocturnal dyspnea, oxygen requirement and significant pulmonary disease, including chronic obstructive pulmonary disease, patients meeting Medicare criteria for home oxygen.
- Carbon monoxide diffusing capacity (DLCO) less than or equal to 80%.
- Patients with a prior history of cardiac or pulmonary toxicity after receiving anthracyclines, such as doxorubicin, daunorubicin, mitoxantrone, bleomycin, or carmustine (BCNU).
- Patients with greater than or equal to grade 2 baseline pulmonary or cardiac symptoms.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00088374
|United States, Maryland
|National Cancer Institute, National Institutes of Health
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|William M Linehan, M.D.
|National Cancer Institute (NCI)
Additional Information:
|Responsible Party:
|William M. Linehan, M.D., National Cancer Institute, National Institutes of Health
|ClinicalTrials.gov Identifier:
|NCT00088374 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
04-C-0238 ( Other Identifier: Clinical Center (CC), National Institutes of Health (NIH) )
040238 ( Other Identifier: Clinical Center (CC), National Institutes of HEalth (NIH) )
|First Posted:
|July 26, 2004 Key Record Dates
|Results First Posted:
|September 29, 2011
|Last Update Posted:
|July 27, 2012
|Last Verified:
|July 2012
Kidney Cancer
Von Hippel Lindau Disease
Renal Tumor
Kidney Neoplasms
Carcinoma, Renal Cell
Von Hippel-Lindau Disease
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neurocutaneous Syndromes
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Abnormalities, Multiple
Congenital Abnormalities
Genetic Diseases, Inborn
Fluorodeoxyglucose F18
Molecular Mechanisms of Pharmacological Action


text: Natalia Starr was in the kitchen chatting with her man and decided to live chat with him cause she wanted to show off her smoking hot body. She started to take out her amazing tits to play with them, but soon got caught by her stepmom who totally surprised her. Jamie Valentine started yelling at her about sexting and whoring around online, so she screamed at her to go to her room. Jamie later went to apologize to Natalia for overreacting. Jamie told her it's hard to see her as an adult now, and she wanted to make it up to her by letting her live chat with her man while Jamie joined in too. Jamie helped Natalia take her top off, then she whipped out her massive jugs and it was on. These two put on one hell of a show for Natalia's man while they ate pussy and scissored till cumming hard!


text:
|JARDIN DE MADELEINE PDF or ePub books
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|PDF, e-Pub, Kindle, Mobi, Audible
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text:
There is no country in the world that is not experiencing first-hand the drastic effects of climate change. Greenhouse gas emissions continue to rise, and are now more than 50 percent higher than their 1990 level. Further, global warming is causing long-lasting changes to our climate system, which threatens irreversible consequences if we do not take action now.
The annual average losses from earthquakes, tsunamis, tropical cyclones and flooding amount to hundreds of billions of dollars, requiring an investment of US$6 billion annually in disaster risk management alone. The goal aims to mobilize $100 billion annually by 2020 to address the needs of developing countries and help mitigate climate-related disasters.
Helping more vulnerable regions, such as land locked countries and island states, adapt to climate change must go hand in hand with efforts to integrate disaster risk measures into national strategies. It is still possible, with the political will and a wide array of technological measures, to limit the increase in global mean temperature to two degrees Celsius above pre-industrial levels. This requires urgent collective action.
Goals in action
Protectors of our planet's lungs
In Peru's Southern Amazon, the indigenous Harakmbut people are fighting against climate change. MORE >
Drones for Social Good
How could drones possibly help to fight the impacts of climate change? The lowest lying country in the world, the Maldives, is giving it a shot. MORE >
A Guilt-Free Holiday
Montenegro is attracting ever-growing numbers of tourists. But just like any other tourist destination, this beautiful Western Balkan country can be harmed by booming tourism. That's why we're helping Montenegro to go carbon-neutral. MORE >
Feeding a family, nourishing a community
1 out of 2 children in Guatemala suffers from malnutrition. A new initiative is working with local farmers to change that. MORE >
The climate shifts. Bhutan responds.
Despite the susceptibility of Bhutan's public health to climate change, the country has worked hard to strengthen its capacity to adapt to climate change. An important innovation of the Bhutanese initiative is linking climate data with epidemiological surveillance. MORE >
Learning to restore and protect Azerbaijan's farmlands
With EU funding and UNDP support, the Clima East Pilot Project in Azerbaijan is working to teach and establish sustainable pasture management practices, improve the fertility of pastures and forests and prevent soil erosion and landslides. MORE >
Water in Myanmar's Dry Zone
In the Dry Zone, chronic poverty is directly correlated with the effects of drought and climate change. UNDP supports efforts to secure water resources and reduce food insecurity in the most vulnerable townships.. MORE >
In search of water
615,000 people are currently displaced by the drought in Somalia. A newly-built water dam may just deliver some of the badly-needed relief. MORE >
Supporting Mali's women to adapt to climate change
Climate change has led to more drought and shorter rainy seasons in Mali. The government has partnered with UNDP to strengthen agricultural communities and empower women to mitigate the social and economic impacts of climate change. MORE >


text:
Hazel Park police Friday afternoon arrested a man driving a Subaru carjacked in Ferndale after they say he tried to rob a restaurant, fled from police and crashed in Detroit.
Police in both cities are working to determine whether the suspected robber is the same man who carjacked the vehicle he was driving.
Hazel Park police said the man implied he had a gun and tried to rob a cashier about 1:15 p.m. at Hardee's, 23240 John R.
'The girl working the register panicked and froze,' said Hazel Park police Sgt. John Colley. 'The suspect got spooked and ran out without getting any money.'
The suspected robber fled from police and crashed into a parked car near Seven Mile and Conant in Detroit.
Ferndale police since Thursday have been looking for a carjacker who stole a resident's vehicle after unsuccessfully trying to carjack three other vehicles within a three-block area in less than an hour.
A Ferndale man was with his teenage son in a Subaru Impreza in their driveway in the 700 block of Wordsworth about 10:30 p.m. Thursday when the carjacker stole the vehicle, police said.
'The victim had just pulled in the driveway when the carjacker approached him, stuck something hard against the victim's chest and demanded his car keys,' said Ferndale Police Lt. William Wilson. 'The victim complied and yelled for his son to go in the house.'
The carjacker drove off, heading west on Wordsworth toward Hilton.
The carjacker is described as black, 25 to 30 years old, clean shaven, with balding or very short hair. He was wearing a hooded jacket or sweatshirt and carrying a light brown satchel.
The carjacker spent an active night in Ferndale.
At 9:11 p.m. he was driving a Chevy Malibu when he was involved in a hit-and-run accident in the 500 block of Academy. He abandoned the Malibu, which was carjacked from its owner Tuesday in Detroit, and fled on foot, police said.
As police responded to the hit-and-run accident, dispatchers at the police station began receiving a series of calls about attempted carjackings in the area.
At 9:44 p.m., two men were sitting in a car on Silman Street in front of their house when the unknown man opened the driver's door and tried to pull the driver out of the vehicle. The driver pushed the assailant away, drove off and called police, Wilson said.
A short time later, the man showed up in the parking lot at the State Fair Market, 726 Hilton, and unsuccessfully tried to force a motorist from his Chevy Trailblazer. The man held the carjacker off.
The carjacker then unsuccessfully tried to steal another man's car in the market parking lot.
'The suspect demanded the car from the owner and hit the owner in the head with a something in a brown paper bag,' Wilson said. 'The victim heard the sound of glass breaking. He suffered some injuries and was bleeding when the suspect fled on foot.'
Several minutes later the unknown suspect carjacked the Subaru a couple blocks away.
Anyone with information is asked to call Ferndale Police at 248-541-3650.


text:
Michael Kane
Knoy 273
401 N. Grant Street
West Lafayette, Indiana 47907
Dr. Michael Kane is an Associate Professor of Computer Technology. Dr. Kane's teaching and scholarly interests include computational genomics, biotechnology, computational life sciences, and information systems in support of the pharmaceutical, biotechnology and life sciences industry. Dr. Kane has numerous peer-reviewed manuscripts, technical and editorial publications, book chapters and presentations, serves on the editorial advisory board of Genomics and Proteomics, and is a member of several technical and research societies.
- PhD (Molecular Pharmacology), Purdue University West Lafayette, IN, 1996.
- BS (Biological Sciences), Illinois State University Normal, IL, 1988.
- 2007 - Outstanding Non-Tenured Faculty Award, Department of Computer and Information Technology
- 2006 - Best Research Poster Award, Faculty Convocation, College of Technology
- 2006 - Outstanding Faculty in Discovery Award, College of Technology
- 2006 - Seed for Success Award, Purdue University
- 2005 - Best Research Poster Award, Faculty Convocation, College of Technology
- 2005 - Biomedical Informatics Course Fellowship, National Library of Medicine
- 1996 - Jenkins/Knevel Excellence in Research Award, School of Pharmacy
- 1995 - Purdue Research Foundation Fellowship
- 1989 - Abbott Laboratories Presidential Award
Refereed Articles and Conference Papers/Presentations/Abstracts
- Kane, M.D., Springer, J.A., and Sprague, J.E. (2008). Drug Safety Assurance through Clinical Genotyping: Near-Term Considerations for a System-Wide Implementation of Personalized Medicine. Personalized Medicine 5(4): 387-397.
- Kane, M.D., Springer, J.A., Iannotti, N.V., Gough, E.S., Johns, S.M., Schlueter, S.D. and Sepulve (2008). Identification of Development and Tissue-Specific Gene Expression in the Fathead Minnow Pimephales promelas, Rafinesque using Computational and DNA Microarray Methods. Journal of Fish Biology 72, 2341-2353.
- Zhang, M., Ouyang, Q., Stephenson, A., Kane, M.D., Salt, D., Prabhakar, S., Burgner, J., Buck, C. (2008). Interactive analysis of systems biology molecular expression data. BMC Systems Bioinformatics 2:23.
- Kane, M.D. and Summers, K.H. (2007). Challenges and opportunities in pharmacogenomics and therapeutics. Journal of Managed Care Pharmacy 13(7): 607-608.
- Kane, M.D. and Brewer, J.L. (2007). An Information Technology Emphasis in Biomedical Informatics Education. Journal of Biomedical Informatics 40: 67-72.
- Kim, H., Kane, M.D., Kim, S., Dominguez, W., Applegate, B.M, and Savikhin, S. A (2007). Molecular Beacon DNA Microarray System for Rapid Detection of E. coli O157:H7 that Eliminates False Signal Risk. Biosensors and Bioelectronics 15:1041-1047.
- Perry, L., Heard, P., Kane, M., Kim, H., Savikhin, S., Dominguez, W., Applegate, B. (2007). Application of multiplex PCR to the detection of pathogens in food. Journal of Rapid Methods and Automation in Microbiology 15: 176-198.
- Kemp, M.Q., Liu, W., Thorne, P.A., Kane, M.D., Selmin, O., Romagnolo, D.F. (2006). Induction of the transferrin receptor gene by benzo[a]pyrene in breast cancer MCF-7 cells: Potential as a biomarker of PAH exposure. Environmental and Molecular Mutagenesis 47: 518-526..
- Kane, M.D. (2005). Technical Issues in DNA Microarray Production and Utilization: Impact on Clinical Research.. Expert Review of Molecular Diagnostics
- Kane, M.D. (2003). Meeting Highlights: 3rd International Symposium on Early Toxicity Screening: Early ADME-Tox Screening Approaches. Expert Opinion on Drug Safety
- Nagel, A.C., Thompson, J.D., Marino, M.A., and Kane, M.D (2003). Spanscript: A Novel Method for Deriving Non-Redundant 3' cDNA Libraries for DNA Microarray Production. Hardiman, G, Microarray Methods and Applications: Nuts and Bolts
- Kane, M.D., Lin, H-S, Dombkowski, A.A., Diakiw, A., Nagel, A.C., Flexon, A., Leifheit, M., Sprague, (2003). Accelerating Preclinical Drug Development Using A Microarray-Based Method for Detecting Oxidative Enzyme (P450) mRNA Induction and Other Metabolic Genes in the Rat.. Hardiman, G, Microarray Methods and Applications: Nuts & Bolts
- Kane, M.D. (2002). Aligning experimental design with bioinformatics analysis to meet research objectives.. Cytometry
- Kane, M.D., Dombkowski, A.A., and Madore, S.J. (2002). The Emerging Utility of Oligonucleotide Microarrays. Lu, Q. and Weiner, M., Gene Cloning and Expression Technologies
- Kane, M.D. (2001). Screening for xenobiotic-mediated P450 induction using a dedicated DNA microarray protocol.. Journal of Clinical Ligand Assay
- Sprague, J.E., Worst, T.J., Haynes, K., Mosler, C.R., Nichols, D.E. and Kane, M.D. (2001). The pharmacodynamic characterization of an antisense oligonucleotide against monoamine oxidase-B (MAO-B) in rat brain striatal tissue.. Cellular and Molecular Neurobiology
- Kane, M.D. and Pisano, M. (2001). Outsourcing genomic and proteomic technology: A value-added solution.. Helix
- Kane, M.D., Lipinski, W.J., Callahan, M.J., Bian, F., Durham, R.A., Schwarz, R.D. Roher, A.E. and Wa (2000). Evidence for seeding of b-amyloid by intracerebral infusion of Alzheimer brain extracts in b-amyloid precursor protein-transgenic mice. Journal of Neuroscience
- Kane, M.D., Jatkoe, T.A., Stumpf, C.R., Lu, J., Thomas, J.D, and Madore, S.J. (2000). Assessment of the sensitivity and specificity of oligonucleotide microarrays. Nucleic Acids Research
- Kane, M.D., Schwarz, R.D., St. Pierre, L., Watson M.D., Emmerling, M.R., Boxer, P.A., and Walker, G. (1999). Inhibitors of V-type ATPases, bafilomycin A1 and concanamycin A, protect against b-amyloid-mediated effects on 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.. Journal of Neurochemistry
- Kane, M.D., Vanden Heuvel, J.P., Isom, G.E., and Schwarz, R.D. (1998). Differential expression of group I metabotropic glutamate receptors (mGluRs) in PC12 cells: role of nerve growth factor and ras.. Neuroscience Letters
- Kane, M.D., Yang, C.W., Gunasekar, G. and Isom, G.E. (1998). Trimethyltin stimulates protein kinase C translocation through receptor-mediated phospholipase C activation in PC12 cells.. Journal of Neurochemistry
- Yan, S.D., Stern, D., Kane, M., Kuo, Y-M., Lampert, H.C., and Roher, A.E. (1998). RAGE-Ab interactions in the pathophysiology of Alzheimer disease.. Restorative Neurology and Neuroscience
- Pavlakovic, G., Kane, M.D., Eyer, C.L., Kanthasamy, A., and Isom, G.E. (1995). Activation of protein kinase C by trimethyltin: relevance to neurotoxicity.. Journal of Neurochemistry
- Sun, P., Borowitz, J.L., Kanthasamy, A.G., Kane, M. D., Gunasekar, P.G., and Isom, G.E. (1995). Antagonism of cyanide toxicity by isosorbide dinitrate: possible role of nitric oxide.. Toxicology
Industry Engagement:
2002-2004 - Nucleico, LLC
President and Co-Founder
2000-2002 - Genomic Solutions, Inc.
Vice President of Research and Development
1998-2000 - Parke-Davis Pharmaceuticals
Senior Scientist
1996-1998 - Parke-Davis Pharmaceuticals
Postdoctoral Fellow
1988-1991 - Abbott Laboratories
Research Associate


text:
When Donald Mooring took over the girls basketball program at South Lenoir he vowed a better brand of basketball.
It showed against North Lenoir on Friday.
DEEP RUN � When Donald Mooring took over the girls basketball program at South Lenoir he vowed a better brand of basketball.
It showed against North Lenoir on Friday.
Heather West scored 23 points and Demeyia Adams added 11 points and 17 rebounds as the Blue Devils played as good a first half of basketball as Mooring could have hoped for in their 72-49 win over the Hawks at home.
Caroline Jones added 13 first-half points and three assists and Marquia Suddeth scored nine points and grabbed six boards as South Lenoir (5-2) hit 17 of 30 field goal attempts in the first half, committed only 10 turnovers and forced the Hawks (1-8) into 13 in the first 16 minutes of play.
�We�re improving around here. We�re starting to slow down and do the little things that make basketball pretty,� Mooring said.
�No, it wasn�t perfect. But we�re getting better with each game.�
The Blue Devils, who have already exceeded their win total from last season, hit four of their first five shots in building an early 8-3 lead and finished the half shooting 57 percent.
Meanwhile, the Hawks couldn�t seem to keep the ball and when they did get a shot off more often than not it didn�t fall.
North Lenoir turned it over 34 times on the night � 21 in the second half � while South Lenoir had just 14 turnovers heading into the final period.
Quoya Porter scored the first eight points for North Lenoir, which fell behind by as many as 26, and was done in by a key 9-0 spurt by the Blue Devils in the second period.
Porter led the Hawks with 19 points. Emily Varnell had nine points and 11 rebounds, nine offensive, for North Lenoir, which outrebounded South Lenoir 47-43.
South Lenoir had 15 offensive rebounds and 16 second-chance points.
The Hawks scored the first 11 points of the game, and until a late South Lenoir run made things a little tense North Lenoir was completely in control.
Billy Summers and Jauquaz Jones scored 17 points each and North Lenoir (6-3) blew things open with a 26-point second quarter.
Freshman Jonte Midgette scored a game-high 24 points for South Lenoir (3-4), which got the Hawks� lead down to nine at 68-59 with just over 2 minutes to play. But they were able to answer with baskets on back-to-back possessions to not allowed the Blue Devils to get any closer.
The nine-point margin was the closest the game had been since was 21-12 early in the second quarter.
Ishmael Baldwin added 17 points and Jaquan Wooten scored 15 for the Blue Devils, who dropped their second game to North Lenoir this season. The Hawks also got 11 points from Javonta King.
A moment of silence was held prior to tip-off to honor the 26 victims and their families of the deadly shooting that took place early Friday at an elementary school in Newtown, Conn.
Ryan Herman can be reached at 252-559-1073 or email@example.com. Follow him on Twitter: @KFPSports.
North Lenoir 19 9 9 12�48
South Lenoir 23 19 16 14�72
HAWKS (1-8) � Quoya Porter 19, Varnell 9, Haerer 7, Goodall 4, Foster 3, Lee 2, Howard 1, Murray 1, Supel, Hart, Kremer.
BLUE DEVILS (5-2) � Heather West 23, Caroline Jones 13, Demeyia Adams 11, Suddeth 9, Meready 5, Franklin 5, Pelletier 2, Braxton 2, Williams, Epps, Stapleford, Hardy.
North Lenoir 13 26 19 19�77
South Lenoir 8 14 19 25�66
HAWKS (6-3) � Jauquaz Jones 17, Billy Summers 17, Javonta King 11, Troy 8, Rouse 6, Pridgen 4, Sutton 4, J. Robinson 2, Carlton 2, K. Robinson, Davis, Stocks, Letchworth.
BLUE DEVILS (3-4) � Jonte Midgette 24, Ishmael Baldwin 17, Jaquan Wooten 15, Jones 6, Davis 2, Turner 2, Janning, Garner, Smith.