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Welcome to A.E. Corporate Services, your global landmark for comprehensive business services and advice.
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subset: commoncrawl


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Kerala is known as the land of many things: God's Own Country or the Land of the Coconut Trees; but, to us, it'll be known as the Spice Garden of India. Even though my wife and I were born in India and lived there for some time, we have never visited Kerala. Kerala is the southernmost state of India, towards the edge of the Indian Ocean.
Mrs.CurryonTravel and I got an opportunity to visit the region in mid-November. The weather was a little chilly in mountains of Munnar, however in Kumarakom and Thekaddy it was just right. Can you imagine a better 8-night/7-day trip surrounded by the mountains, and beaches, and teas?
What to do there
We booked our tickets from Ahmedabad to Kochi. This involved flying from Ahmedabad to Mumbai to Kochi with a 2/3-hour car ride to Munnar. For Kerala the vacation packages usually include a car and a driver throughout your stay. The car comes with prepaid miles (or kilometers since we have to use the metric system) and any excess mileage is extra.
Hacking tip: the driver was with us through our trip, they usually stay in the driver's quarters of a resort. Tipping is common and expected daily, such as tea or dinner for the driver, however some caution is also recommended. Drivers know the tourist traps and they further make commission by taking you to them. Later in the post I'll mention areas or events that were tourist traps and could be avoided. Call the agent if you have reservations about your driver, and they should be able to send someone new the next day. If you need help with the booking, feel free to contact me.
Munnar city is in the mountain regions of Kerala. A popular destination for newlyweds, the mountains engulf you with the green vista. You can spot different shops, some selling crafts and some selling coconuts. We stopped once to drink some fresh coconut water, to truly feel we are in the South. Tea is grown all over the mountain and you'll be sure to see tea-pickers picking tea, wrapping it, and carrying it to the factory. The mist of the mountains seems to lay suspended as we drover higher and higher, and you could feel the cool mountain air thinning. We reached our hotel late in the afternoon, and after checking in we recuperated from the flight and prepared for the next day.
Tea leaves that beckon
The next morning, we got ready and had breakfast by 9. Munnar is great for relaxing, as there are spa options however they are very different from the spas we experience in the west. We started the day visiting [Matupetty Dam]. As we drove through the small falls spread across the mountainous region, we arrived at the old dam. The purpose of the visit is not solely for the dam, since that was not too exciting, but rather to walk past it and hike to one of the top points of the mountain. The views from the mountain were exceptional, we could see the mist covering parts of the mountain. As we walked down from the hike we came across some local fruit stalls. We bought some fruits that were local to Munnar, and I was introduced to jackfruit. I ended up buying more as they were delicious.
After Matupetty Dam, we decided to visit the Tata Tea Factory. As a tea connoisseur, which is something I hope to be, visiting the factory of one of the biggest tea growers was a must. We had an option to visit the [nature park], however the lines were incredibly long and after talking to a few locals it felt like a tourist trap. The entry tickets were reasonable and inside we were greeted with a guide. After a 20-minute video about the history of tea in the region, we made our way to the factory floor. The factory is not operational, but the old machines were left for the tourist. We walked through the floors to learn how teas are converted from leaves to beans. I was disappointed when we weren't given free samples of tea, instead you had to pay for it; and it wasn't the freshly made chai-tea that I meticulously make but rather a hot water machine.
Tata Tea Factory
After the Tata Tea Factory, we visited the Munnar market, akin to a downtown area. Located below the mountains, the market can get very busy closer to the evening. The wife was very excited to visit the shops and potentially get some bargains for handcrafts, spices, and other items. After visiting a few shops to get the general price sense, we came across a wholesaler located in the bowels of the market. After some haggling we get some great deals on fresh spices, especially spices used for South Indian cooking; something the wife cooks regularly. The handcrafts were generally the same price compared to the shops we found by the mountains, but food items such as fruits and banana chips were a good buy.
The next day we left for Thekkady. After the mountain regions of Munnar, Thekkady was another quiet getaway. Along the way we stopped at an Elephant Junction. The Elephant Junction allows tourists to ride an elephant or even take a "shower" with the elephant (seriously…). We opted for the ride. For someone that has never ridden on an elephant it was a unique experience. After checking into the hotel we relaxed and enjoyed a quiet evening.
The next morning, we visited the Periyar National Forest. The forest offers several options to hike and tours to look at animals and plants that reside in the forest. After spending an hour walking around the forest, we chose instead to take a "safari" on the borders of Tamilnadu. Tamilnadu is a bordering state of Kerla, and the views along the border are divine. You'll find many folks canvassing for tours, with different options. We made a deal for a tour of 4 points to see along the border, with the whole jeep to ourselves (bargaining is recommended). The safari was the highlight of our stay in Thekkady, with the water fall views so pristine.
Safari Point #3
After Thekkady, we made our next stop to Kumarakom. On the way our driver mentioned that we will cross a big market, a great spot to shop for clothes, antiques, and other souvenirs. We spent the afternoon in the market, exploring and shopping for some sarees. The collection was interesting, but Mrs. CurryonTravel had her fun. After checking in the Zuri Resort, we freshened up and walked around the resort to explore.
Kumarakom is not in the mountains, rather it's a coastal city. Expect a humid climate, with its share of insects. Folks come here to relax and enjoy the backwaters. You have the option to rent a houseboat and spend a night on the waters with 5-star service at your beck and call. Spending a night on a houseboat, or renting a boat for a few hours can get a little pricey. Mrs. CurryonTravel and I found another group of tourists and we negotiated a 3 hour ride in the backwaters. For a fraction of the cost, we were able to tour the houses and fishing boats on the water and see the beauty that one would expect in Kerala.
How to get there
Our route was local, since we were in Gujarat. However, any trip to Kerala will have to be through Kochi, closest city with a major airport. The travel time between Kochi and Munnar is 2-3 hours by car, and could be longer based on the traffic.
A car and drive are standard ways of vacationing around Kerala, and one I would recommend to see the sights and be flexible with your plans.
Where to stay
I would recommend the Kofiland Resort in Thekkady and the Zuri Resort in Kumarakom.
Kofiland in Thekkady
The level of service, cleanliness, and beauty of these resorts make visiting Kerala worthwhile. Chef Boban at the Zuri Resort was very accommodating with our requests, and he made the best Nizam Handi I've tasted.
Zuri in Kumarakom
As always drop me a note if you need additional information about my trip or if I could help in booking your adventure. I would love to hear about your experience as well. Did my recommendations come in handy? What else is there to see?
Safe Travels,
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Apocalypse Now
Apocalypse Now is a 1979 epic Vietnam War film directed by Francis Ford Coppola and co-written by Coppola and John Milius, starring Marlon Brando, Robert Duvall, and Martin Sheen. It was loosely based on Joseph Conrad's novel, Heart of Darkness.
In 2001, an extended cut, Apocalypse Now Redux, was released that restored 49 minutes of deleted scenes.
The film was selected for preservation in the National Film Registry in 2000.
Green Beret Colonel Walter E. Kurtz (Marlon Brando) has gone insane and is leading a tribe of Montagnards to fight the war on his own accord in Cambodia, setting himself up as a demigod. The American high command decides to send in 173rd Airborne Brigade Captain Benjamin Willard (Martin Sheen) to assassinate him. Serving as his escort is the crew of a US Navy PBR known as the "Street Gang", consisting of Chief (Albert Hall), Lance (Sam Bottoms), Clean (Laurence Fishburne) and Chef (Frederic Forest).
As they go up the Nung River to Kurtz's compound, both Willard and the PBR crew begin to slowly lose their sanity to the horrors of war around them and succumb to the darkness that lurks within humanity.
Why It Rocks
- Has a dark and gritty story that is excellently done.
- Amazing acting, especially from Marlon Brando.
- Breathtaking (and oftentimes disturbing) cinematography.
- Lots of iconic dialogue and scenes. Some of the dialogue, especially Kurtz's, were notably ad-libbed.
- An eerie and haunting soundtrack that boosts the film's atmosphere. The movie also makes great usage of "The End" by The Doors and Richard Wagner's "Ride of the Valkyries".
- All around excellent sound design, which showcases many surround sound systems beautifully.
- The uniforms, weapons and vehicles used are very much accurate and feel authentic.
- Memorable quotes such as "I love the smell of napalm in the morning." and "The horror... the horror..."
Bad Qualities
- As iconic as the helicopter raid scene is, it ended up polarizing audiences because of its cinematography and usage of "Ride of the Valkyries". To this day, people are divided over whether the film is pro-war or anti-war because of this scene.
- The rather long French plantation scene in Redux was also met with polarizing reception. The Final Cut remedied this.
- The movie used to have an end credits sequence, but it got removed because the audiences misinterpreted it as Kurtz's compound getting blown up by a U.S. airstrike, which wasn't Coppola's intention (the film was shot in the Philippines and the government required that the set be destroyed; Coppola decided to capture footage of the set's demolition and chose to use it as a graphical background).
Apocalypse Now has received critical praise, with a 97% on Rotten Tomatoes. Roger Ebert gave the film 4 stars, added the film to his Great Movies list and considered it to be the finest Vietnam War film ever made.
Box Office
The film also performed well at the box office, grossing $150 million worldwide out of a $31 million budget.
Awards and nominations
The film won the Palme d'Or at the 1979 Cannes Film Festival, and has won two Academy Awards, Best Sound (for Walter Murch, Mark Berger, Richard Beggs and Nathan Boxer) and Best Cinematography for Vittorio Storaro.
It also won three Golden Globe Awards: Best Director for Francis Ford Coppola, Best Supporting Actor for Robert Duvall, and Best Original Score for Carmine and Francis Ford Coppola, not to mention two British Academy Film Awards (Best Supporting Actor for Robert Duvall and Best Direction for Coppola) and earning a spot on the AFI 100 Years... 100 Movies list, ranking at #30.
- The usage of Ride of the Valkyries was supposed to invoke that the gunship crew were the villains, as Wagner's music was a favourite of Nazis and was often blasted through concentration camps (Wagner himself was not a Nazi, as he died before Hitler was even born)
- Due to there being no film processing laboratories in the Philippines at the time, Coppola did not see a single second of the film before he returned to the States, meaning he shot the film blind. He had to sort through hundreds of hours of film, and post production took two years.
- The reason The Godfather got a TV adaptation was because Francis needed the budget for this film.
- The film had a notoriously troubled production, during which Martin Sheen suffered a near-fatal heart attack, Dennis Hopper got Laurence Fishburne addicted to heroin, and Francis Ford Coppola attempted to kill himself, amongst other setbacks. Coppola even said during the film's premiere in the Cannes Film Festival that "my film is not about Vietnam; it is Vietnam". The production and its problems were chronicled in the 1991 documentary film, Hearts of Darkness: A Filmmaker's Apocalypse.
- Laurence Fishburne was only fourteen years old when shooting began in March 1976, as he had lied about his age in order to get cast in his role. The film took so long to finish that Fishburne was seventeen (the same age as his character) by the time it was released in 1979.


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Flipping & Frying
From: £
Verified bookings: 0
Reviews: 1
Media Files
Price from: £
Fish Cod £4.50 Haddock £4.50 Chips Small £2.50 Large £2.75 -75p when bought with Fish or accompaniment item Fishcake £1.25 Sausage £1.25 Chicken Nuggets £1.75 Peas | Curry | Gravy £1.00
We are based in Lincolnshire and serve some of the finest Traditional Fish and chips around the East Midlands but can cover events further afield upon request. If you have any questions please feel free to give us a call and you can be guaranteed a friendly reception!
1 Reviews
Andrew Moore• 1 May 2018
"Took over the van April now completely independent and based in Lincoln no contact with previous management. Gave myself 4 stars ensure quality is good but no-one is perfect:-) Love my customers and hope they like our service
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Home Tags GWSN
Tag: GWSN
M!Countdown E593 (2018-10-25)
The Halloween themed episode of M!Countdown is back with comebacks from MONSTA X, Stray Kids and Golden Child.
The Show E168 (2018-10-23)
This week's The Show is in a concert format from Injae.
Inkigayo E979 (2018-10-21)
Inkigayo is back this week with comebacks from Lee Hong Gi, SOYA, APRIL, Sohee and Kim Dong Ha.
Simply K-Pop E333 (2018-10-20)
Simply K-Pop the K-pop show hosted in English has comebacks this week from Kim Dong Han and APRIL
Music Core E607 (2018-10-20)
Music Core is back this week with comebacks from APRIL and Lee Hong Gi
Music Bank E951 (2018-10-19)
Music Bank is back this week with comebacks from Lee Hong Gi, APRIL and Kim Dong Han
M!Countdown E592 (2018-10-18)
M!Countdown is back with comebacks from Lee Hong Gi, Weki Meki and more!
Simply K-Pop E332 (2018-10-13)
Jacob and Kevin of THE BOYZ hosts the weekly K-Pop show actually in English! This week has comebacks from SoYou and Nakjoon!NOIR - Airplane...
The Show E166 (2018-10-09)
This week The Show is coming from the Hwacheon Peace Concert.
Inkigayo E977 (2018-10-07)
SBS Inkigayo is back this week with the hottest K-Pop performances for the week,with comebacks from Yuri, iKON, SoYou and The Rose.
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drifterzero May 21st, 2019 (edited) 92 Never
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- 001-Prologue.txt
- An event or action that leads to another event or situation.
- You know that feeling you get in your stomach, like you just dropped down a roller coaster? The kind where your balls travel up your throat or out your ass? That's the feeling you get after you've been pulled over. Day turns night. If a break-up is cocaine, getting pulled over is baking soda and a spoon.
- Sarah was a green eyed beauty. She had one of those pleasant faces. The type that automatically makes your facial muscles twitch into a smile. Her personality was that sensation when you take a shot of your favorite liquor. It warms your chest and radiates outward. Sarah was Pendleton 1910. I hadn't originally been attracted to her, but she grew on me. We both had our life in order. I had helped build up her business. I was always computer savvy. So reverse-engineering Googles local place algorithm to boost her business to the top took minimal effort. It was a simple matter of doing enough submissions to local directories, building a good website with quality content, and incentivizing her existing customer-base to write positive reviews on Yelp and Google Local.
- Tap-tap.
- "Roll down your window" said the officer.
- At this point I knew the 2600 square foot house, with 5 bedrooms and 2.5 bathrooms, that I had just put an offer on wasn't happening. Sarah never believed that I would go to jail for months. She was the eternal optimist, I am the eternal pessimist. Things never went as bad as I thought or as easy as she thought. I guess the pendulum always settles in the middle. Eleven months later the pendulum would swing me into jail.
- I tend to create self-fulfilling prophecies. I push things in directions I don't want them to go. I am the scorpion on the foxes back. When I called it off with Sarah, I only did it because I wanted to see pain in those green eyes of hers. I wanted to see tears swell in the edges, lips to quiver, and the floor drop from under. I had that power. I wanted her to finally feel what I was feeling. Of course she never would. I certainly made her feel terrible, but she would never catch up to me.
- "But we can still work things out, right?" said a confused Sarah.
- Flipping a bit to zero I responded. "No, we're done. Its over."
- I instantly regretted my actions. But I wouldn't let those feelings get in the way of my sense of duty. I had a mission to complete, honor was at stake here. Collateral damage, civilian casualties, those are just a part of war. Crippled and broken, I would wear this purple heart with pride.
- A bonafide war criminal now, I decided to buy an RV and explore the country. There was nothing left for me here. Me and my German Shepherd cohort Brooklyn would travel, with fate as our guide. Tech people have to put a name on everything: Web 2.0, Rockstar, 10x Developer, Ninja, and Guru. They call this lifestyle a "Digital Nomad." I think I am more of a Digital Drifter, but whatever. Ultimately it may be just another personal mind fuck to further isolate myself from an already depleting circle of friends.
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The aim of this study was to explore specific conditions and types of genetic variants that specialists in genetics recommend should be returned as incidental findings in clinical sequencing.
Sixteen specialists in clinical genetics and/or molecular medicine selected variants in 99 common conditions to return to the ordering physician if discovered incidentally through whole-genome sequencing. For most conditions, the specialists independently considered three molecular scenarios for both adults and minor children: a known pathogenic mutation, a truncating variant presumed pathogenic (where other truncating variants are known to be pathogenic), and a missense variant predicted in silico to be pathogenic.
On average, for adults and children, respectively, each specialist selected 83.5 and 79.0 conditions or genes of 99 in the known pathogenic mutation categories, 57.0 and 53.5 of 72 in the truncating variant categories, and 33.4 and 29.7 of 72 in the missense variant categories. Concordance in favor of disclosure within the adult/known pathogenic mutation category was 100% for 21 conditions or genes and 80% or higher for 64 conditions or genes.
Specialists were highly concordant for the return of findings for 64 conditions or genes if discovered incidentally during whole-exome sequencing or whole-genome sequencing.
Genet Med 2012:14(4):405–410
There is an increasing consensus that whole-exome sequencing (WES) and whole-genome sequencing (WGS) will continue to improve in accuracy and decline in price and that the use of these technologies will eventually become an integral part of clinical medicine.1,2,3,4,5,6,7 Several recent reports have highlighted the use of WES/WGS in the diagnosis or treatment of patients,8,9,10,11,12 and there is rapid expansion of Clinical Laboratory Improvement Amendments–approved molecular laboratories now providing, or soon planning to provide these services to clinicians.13,14,15 One of the greatest impediments to the immediate application of sequence data to clinical medicine relates to whether, and to what degree, molecular laboratories and clinicians should seek out, interpret, and communicate incidental or secondary (i.e., unrelated to reasons for ordering) genetic findings.
Whatever the clinical indication for WES/WGS, there is considerable potential in each patient to discover large numbers of variants in genes associated with human disease.16 Currently, there are no guidelines for return of incidental findings from clinical sequencing, although there have been proposals for lower- and higher-risk categories or "bins" based on clinical validity and actionability.17 Yet no one has asked whether well-meaning specialists would agree upon incidental findings that would be appropriate to disclose. To explore concordance or discordance that such efforts might face, 16 specialists in genetics independently evaluated 99 common genetic conditions and individual genes and selected those they would recommend reporting back to the patient's physician as incidental findings after WGS.
Materials and Methods
A list was generated of all diseases for which testing is clinically available as registered on the GeneTests website.18 Genes associated with the same disease were combined. The top 88 conditions or genes based on the frequency of laboratory testing were supplemented by adding hereditary breast and ovarian cancer, a condition that was not frequent among laboratories due to patented genes, along with a number of common chromosomal conditions and deletion syndromes currently diagnosed through cytogenetic analysis (Table 1).
The 16 participating specialists were clinical geneticists and/or molecular laboratory directors, most of whom have been involved in early uses of genome-scale data, but there was no attempt to be representative or to include all relevant subspecialists. Each specialist was asked to assume that he/she was serving as a consultant to a laboratory that performs clinical WGS and to decide which variants discovered as incidental findings should be returned in a report to the ordering physician. Specialists were asked to assume that family history was not available, that the patient had no previously recognized clinical features consistent with the disease variant under consideration, that the patient's gender was known, and that it was known whether the patient was an adult or a minor child (under 18 years), but not the exact age. Specialists were asked to assume that the sequencing was perfectly accurate and could detect translocations and repeat expansions perfectly, even though this degree of accuracy is not available through current WES/WGS technologies. Details of the consent process, patient preferences regarding results disclosure, and details about how disclosure of results might be handled by the referring physician were not specified. An additional assumption was that family members of the patient being tested would not have been sequenced or genetically tested for the variant under consideration, thus decisions were made on the basis of the genome findings alone without contextualization by patient medical history or family history.
Specialists provided separate responses as to whether incidental findings should be returned to the physicians of adults and of minor children, and where applicable, in each of three categories of variants: a known pathogenic mutation, a truncating variant presumed pathogenic (where other truncating variants were known to be pathogenic), and a missense variant predicted to be deleterious by in silico analysis. For recessive conditions or genes, specialists were asked to specify whether they would return a variant even in a carrier state, or only if the patient were found to be biallelic (for autosomal recessive) or hemizygous (for X-linked), or not at all. For repeat-expansion disorders, specialists indicated whether they would return a finding of a premutation or full mutation, only a full mutation, or neither. For each possible scenario per disease (adult/child, pathogenic/truncating/missense), specialists were also asked if they had difficulty deciding whether to report the variant. Each specialist could decline to respond due to lack of familiarity with the condition or gene. All of the aforementioned choices were made through pull-down, forced-choice menus. For the purposes of this analysis, conditions or genes were counted if the specialist recommended an affirmative response in the dominant disorders or genes, or in any option of the recessive, X-linked, or expansion disorders or genes.
The specialists did not communicate with each other about their decisions. All 16 specialists are listed as coauthors of this paper. One additional coauthor (S.K.) is a genetic counselor who prepared the lists and assisted with data analyses and manuscript preparation, and a second additional coauthor (A.L.M.) is a contributor in ethics and legal issues who participated in data analyses and manuscript preparation.
Of the 16 specialists who selected conditions, 13 were MDs with or without an additional degree, and 3 were non-MD PhDs; 9 were primarily clinical geneticists, 3 were primarily molecular laboratorians, and 4 were active both clinically and in the molecular laboratory.
The conditions and genes proposed and the number and percentage of specialists who would recommend return of incidental findings based on these are shown in Table 1 (specialist order does not correlate with order of coauthors). For each of the 99 conditions and genes, an average of 13.5 (s.d. 1.9, range 8–16) specialists suggested incidental genetic findings be returned about adults and 12.8 (s.d. 2.3, range 4–16) suggested findings be returned about children if there was a known pathogenic mutation. For each of 72 conditions and genes (excluding trinucleotide repeat–expansion, chromosomal, and deletion conditions, and conditions caused by only a specific known mutation), an average of 12.6 specialists (s.d. 2.3, range 8–16) and 11.9 specialists (s.d. 2.2, range 7–15) suggested that incidental findings of truncating variants be returned about adults and children, respectively. An average of 7.4 specialists (s.d. 1.5, range 4–10) and 6.6 specialists (s.d. 1.7, range 3–9) suggested that incidental findings of a missense variant predicted to be pathogenic by in silico analysis be returned about adults and children, respectively. The concordance in favor of disclosure was 100% for 21 conditions or genes in the Adult/Known Pathogenic Mutation category, 80% or higher for 64 conditions or genes, and at least 50% for all conditions or genes.
Concordance was higher for returning incidental information about conditions that had potential for medical intervention (such as cancer predisposition syndromes) than for those without such potential (such as developmental or neurodegenerative disorders). Concordance was also higher when returning incidental findings about adults rather than about children, and for returning known pathogenic mutations and presumed pathogenic truncating variants rather than missense variants predicted to be pathogenic. The total number of genes or conditions selected by each specialist varied along these axes (Supplementary Table S1 online and Supplementary Figure S1 online) whereas the discomfort that specialists felt in making the decision varied inversely along the same axes (Supplementary Table S2 online).
This report presents an exploratory description of concordance and discordance around specific conditions and genes with respect to incidental findings in the context of clinical WGS/WES. There were 21 conditions or genes in which all 16 specialists agreed that known pathogenic mutations should be disclosed if found incidentally in adults, and 4 conditions for which all 16 specialists agreed that known pathogenic mutations should be disclosed if found incidentally in minor children (Supplementary Table S3 online). There was considerable concordance among all 99 conditions or genes for known pathogenic mutations, with a majority of specialists selecting nearly every condition or gene for return as an incidental finding.
Substantial discordance was observed across two major domains. First, some specialists were more reluctant than others to disclose incidental findings. For example, even within the category of adult/known pathogenic mutations, one specialist reported that he or she would recommend disclosure of only 30.3% of the identified genes or conditions, whereas two others thought 100% should be disclosed. Second, there was discordance in judgments about the relative value of different criteria when making decisions about disclosures. For some, whether the result pertained to a child or an adult seemed to be the most relevant factor driving the decision to disclose, whereas for others, the established pathogenicity of the variant was the most important factor. These criteria also influenced whether contributors found a particular decision to be difficult. Additional research is needed to better understand the source of this discordance; for example, whether it reflects primarily differences in clinical or ethical judgment or, in the case of the potential pathogenicity of variants, whether specialists were fully aware of the limited accuracy of in silico prediction tools for missense variants.
These data have a number of limitations. The specialists were not representative and were of varying degrees of expertise. Each specialist responded independently and without interaction that would characterize formal consensus building. Specialists were asked to assume that no information was available about family history or knowledge of signs or symptoms in relatives of the proband, which is a somewhat artificial situation.
The degree of discordance observed suggests that whether considering incidental findings in research subjects or incidental findings in clinical WES/WGS, it may be difficult to reach consensus on a specific list of variants that meet a threshold for disclosure, as called for in various consensus statements on incidental findings. However, in an actual consensus group, experts on a subset of disorders would educate the rest of the group and likely increase concordance. Plans that attempt to factor in subject or patient preferences (which were excluded in this exercise) could make consensus easier or more difficult. In this exercise, the choice was whether to provide such information in a report to the ordering physician, not to the patient. This may have provided comfort to the specialists who were wavering because the ordering physician would have the ability to seek preferences from the patient about how much information to share, as well as the ability to contextualize the report by integrating personal medical history, family history, symptoms and signs, or by referring the patient. The variability in responses surrounding issues for which consensus has already been achieved and published (such as the unreliability of in silico prediction of variant significance) also highlights the need for greater education, even among specialists, as well as the need for extensively curated clinical-grade databases.
In summary, there was considerable concordance and considerable discordance in choices about return of incidental genomic information among specialists queried for this report. The variability in responses suggests that a relatively small panel of specialists is unlikely to embody all of the necessary expertise to achieve consensus about the vast number of genetic variants that will be identified by WES/WGS, especially if additional variants are considered that are less well characterized than those we selected. Modifications to a typical consensus approach may need to be considered, such as collaboration among multiple expert panels, with each panel being composed of specialists in a more narrow focus of expertise. It appears that even genetic specialists are a heterogeneous group and may not be yet fully prepared to deal with the implementation of new genetic technologies.
The authors declare no conflict of interest.
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Funding for this work was provided by National Institutes of Health grants HG02213, AG027841, HG005491, HG005092, HG006615, HG003178, HG006500, CA138836, and HG006485. G.T.B. is supported by the Manton Center for Orphan Disease Research. L.G.B. is supported by intramural funding from the National Human Genome Research Institute. A.L.M. is supported by the Baylor College of Medicine Clinical and Translational Research Program and the Baylor Annual Fund.
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JCO Precision Oncology (2018)
A Model for Genome-First Care: Returning Secondary Genomic Findings to Participants and Their Healthcare Providers in a Large Research Cohort
The American Journal of Human Genetics (2018)
Incidental or secondary findings: an integrative and patient-inclusive approach to the current debate
European Journal of Human Genetics (2018)


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There are a lot of things you forget about once you haven't had a newborn for a few years. You
There are a lot of things you forget about once you haven't had a newborn for a few years. You
Of COURSE I was supposed to post yesterday. Life has just gotten so insane. I swore it was today, and
Intense. That's how I explained my first birth, too. Not painful, just intense, hard work. This time
My due date for baby #3 was 2-16-14. I don't have my babies "ahead of schedule." So
Guess what? I am still pregnant. Apparently, my babies don't seem to ever be in any kind of hurry.
At 39 weeks and 5 days pregnant I was used to waking up a few times a night to
Hello. My name is Amber, and I'm an accidental natural parent. Three and a half years ago,
Potty Training… I thought I would be able to knock this post out easily, but boy was I wrong. Firstly,
I'll be honest. I don't have much to offer in the way of advice or tips when it comes to potty training.
There once was a little girl who traveled across the globe to foreign lands. Equipped with a backpack


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This season's host, AritOkpo discussed these issues with Pamela Adie, Senior Campaign Manager AllOut. Pamela spoke about being formerly married due to family expectations. Further, she spoke deeply about the challenges she faced during this period, emphasizing that all she really wanted at that point was acceptance by her family and loved ones.
She advises parents to love their children unconditionally no matter their sexual orientation.
Pamela said:
"when I came out, my family wasangry and shocked. I did get married but it didn't last because I came out. When I did that I faced a lot of opposition from family and friends, my parents once brought a priest to the house to pray for me."Watch full episode here...


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Expecting a Baby
Already a Parent
Congratulations! By when are you planning for a baby?
Congratulations! How many weeks are you?
Bijal Bhavya Sheth
Nice drive by baby chakra. but my baby just 3 months old and long distance can't travel..
Priya Sood
Hi Bijal. Would have loved to have you. Do take care and check out our articles and reviews of services for your child.
Bijal Bhavya Sheth
Sure Priya. This is the best App.. It is like a Mommy community where we ask, share, get answers, inspired.. lots more to add. Thank you for all your efforts.. This is to all the Mummy's and Baby Chakra team
Priya Sood
So thrilled you find it useful. I'm looking forward to interacting more.
Recommended Articles


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Don Grocott was installed as the new Master of the Worshipful Company of Spectacle Makers on Wednesday 5 October 2016.
Don is well known across the optical world, having been Chairman of the Association of Contact Lens Manufacturers and President of Euromcontact, the European contact lens manufacturers' federation. He was also President of the Association of Optometrists and President of FODO, before spearheading the formation of the Optical Confederation to bring together key players in optics and present a co-ordinated view to government on issues affecting UK optical professionals, manufacturers, retailers, distributors and importers. Don was Chairman of the Optical Confederation until October 2014.
The installation of the new Master and Wardens took place during the Company's annual service at St Bride's, Fleet Street and was followed by a lunch at the historic Apothecaries' Hall in the City of London, attended by visiting City Livery Company Masters and many guests and friends from across optics.


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Welcome, Welcome, Welcome!
Welcome, welcome, welcome to Into the Wild, the first Wild Exclusive Hearthstone podcast on the information superhighway. Thanks for checking out our website!
Into the Wild was born on January 1, 2018! While there were a ton of Standard Hearthstone podcasts, there wasn't a Wild one. So... we made the show we wanted to listen to! Join us each week as we discuss Hearthstone news, meta, decks, and have very special guests, all related to the Wild format of Hearthstone!
DannyDonuts is a hearthstone a writer for Tempo Storm, co host of "Well Met" and member of Team One Trick. He is an expert of mill druid, friend of Majordomo and lover of all things wild
When he's not playing Hearthstone, he is probably beating everyone at auto chess or collecting fine gaming chairs.
Twitter: @DannyDonuts
SaucyMailman is a twitch streamer and wild Hearthstone content creator. He has been playing Hearthstone since vanilla and is at home playing control and weird combo decks.
When not playing hearthstone he can be found hanging out with his parrot Jace or sorting his MTG collection.
Twitter: @Saucymailman


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Walk Date: 09/14/2019
Walk Location: Little Harbor School - Portsmouth, NH
Check-in/Registration Time: 8:30 am
Walk Begins: 10:00 am
Walk Ends: 12:00 pm
For more information, please contact:
Contact Name: Ken & Dorothy La Valley
Contact Phone: 603-862-4343
Contact Email: firstname.lastname@example.com
Online registration closes at noon (local time) the Friday before the walk. However, anyone who would like to participate can register in person at the walk from the time check-in begins until the walk starts. Registration is free and open to the public. Walk donations are accepted until December 31st.
When you walk in the Out of the Darkness Walks, you join the effort with hundreds of thousands of people to raise awareness and funds that allow the American Foundation for Suicide Prevention (AFSP) to invest in new research, create educational programs, advocate for public policy, and support survivors of suicide loss.
Thanks to Walkers and Donors like you, AFSP has been able to set a goal to reduce the annual suicide rate 20% by 2025.
Click the Register Now button at the top of the page to get started right away.
Fundraiser Night
Click here to download a PDF of the above flyer
Walk Route
The Walk is just over 2.5 miles and is dog and stroller friendly.
We're using SignUp.com to organize our upcoming walk.
If you want to volunteer at the event, here's how it works in 3 easy steps:
1) Click I WANT TO VOLUNTEER
2) Review the options listed and choose the spot(s) you like.
3) Sign up! It's Easy - you will NOT need to register an account
Note: SignUp.com does not share your email address with anyone. If you prefer not to use your email address, please contact me and I can sign you up manually at: firstname.lastname@example.com
Paws for Prevention
Friendly, leashed dogs are welcome at the event. AND - with a $10 donation, you can pick up an AFSP Pooch bandana at the Merchandise tent.
Help Spread the Word!
Please help promote the event through your social media outlets! #OutoftheDarkness
There are many more social media outlets, please use any and all to help promote the event. Tell your story about why you walk!
Raise $150 by 09/14/2019 and receive an official Out of the Darkness Walk T-shirt!
Remember, in addition to fundraising online, you will be able to turn in additional cash or check donations at the registration table the day of the Walk.
Resource Fair
Make sure to arrive early to allow time to explore the resources area.
Information tables hosted by local businesses and non-profit organizations will open at 8:30 am. This will be an opportunity to gather literature, hear about upcoming events, and connect with others who are dedicated to raising awareness of mental illness and suicide, strengthening prevention efforts, and providing support to those impacted by suicide loss.
Family Activities
The walk is a family friendly event and we encourage you to bring your children. We will have raffles, temporary tattoos and other kid friendly fun taking place!
Activities of Hope and Healing
Losing someone to suicide or struggling with a mental illness can feel like no one understands what you are going through. Unlike other illnesses, it is difficult to look at someone and know their connection.
There is an honor bead for everyone, whether you have lost a loved one, struggle personally, support a friend and/or family member, or all of the above.
Pop-Up Store
We will have AFSP Tee shirts, sweat pants, hoodies, water bottles, wristbands and lots of other awareness materials for sale during the walk. Payment accepted in the form of cash or credit card.
The Out of the Darkness Community Walk is a journey of remembrance, hope, support, and a walk that unites a campus and community – a time to acknowledge the ways in which suicide and mental illness have affected our lives and our loved ones.


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Diary of a Madman, Page 53
2M readers, 323K subscribers, you're one of the chosen.
I. STEM Analyses
- Stressed? Take a Forest Bath [Mia Everett]: stress is one of the biggest problems in our industry. The question is how you cope with it. The Japanese may have found the answer.
- A Prescription for Snap Spectacles [Antoine RJ Wright]: ever thought about adding prescription lenses into a wearable product like Snap's? Our friend just went ahead and did it.
- This is how Fear & Outrage Are Being Sold for Profit [Tobias Rose-Stockwell]: can a single metric change the world?
- Cryptocurrency Market Map Chart [Sean Everett]: understanding which industries are covered by ICOs and which have been left completely out. Smells like opportunity.
- 21 Terms to Understand Cryptocurrency [Max Middelman]: glossary for a new age of investing.
- Space Tech: A New VC's First Podcast [Sean Everett]: an upcoming $100M fund focused on Space Tech, by the venerable Sebastian Straube.
- This 90/10 Principle Will Make You Stick To Your Nutritional Protocol [Jacob Lyda]: what is the optimal mix of food in your diet?
Spend the money you make in this life, less on things, and more on learning. Formal education works, but startups are even better. You learn more, faster.
II. Dear Diary: The Mission News & MarTech
We've started a new daily feature called The Mission News which covers a variety of topics, not just STEM-related. Here's todays version and one from earlier in the week. We're still finding the right voice, length and content, but consider it somewhere between The Hustle and MIT Tech Review. Happy to hear your comments on what you like best. Short and sweet, educational, zany. You tell us.
I'm also delving deep into the MarTech / AdTech landscape lately, uncovering some interesting tactics for that old party line of right message, right place, right time. The main thing that stands out is the sheer volume of useless acronyms, proliferation of technology solutions, and recent findings that argue against a massively targeted campaign. Besides, personas are so LY.
Meanwhile, P&G, the biggest spender of consumer ads, found that hyperpersonlization isn't moving the needle on sales, from the WSJ:
The company about a year ago said that it would move away from ads on Facebook that target specific consumers, after finding that ultra-niche targeting compromises reach and has limited effectiveness. P&G indicated it wouldn't pull back on overall Facebook spending.
Of course, it could be argued that this is because their products are so pervasive. Everyone needs soap. You don't need to tell me that becuase I'm a millennial dude, I need soap. I just need soap. If you have a niche product, however, you're forced to go a niche route.
You might be wondering why such a thing is important. Three reasons:
- Revenue is every company's problem. Investors want growth. The question of "where are sales going to come from" confronts every business, whether startups or global 100-year blue chips.
- Companies are always willing to spend money on marketing, advertising, and sales when there is a direct and measurable ROI. That is, spending $1 gets you $1.10 in return. The more you spend, the more money you make.
- It's recession proof. People always have to buy something. Buy food, buy clothes, buy living expenses. It what makes the world, and economy, go 'round. That means you have to find a way to get your competitive product in front of these people. That's marketing and advertising.
So if you only spend time on building emerging tech, and never care how or why anyone is going to buy it, you're missing more than 50% of the game.
The question remains a killer: "why do I buy?".
If you feel you can build anything, anytime, with a budget of $0, attract high quality talent and customers, then you've already made it.
III. Emerging Tech
More proof of the 12 Tech Theses of the 2030s:
- Music: the way you make me feel.
- Video: Facebook's movie in a text message. It's coming.
- China: white glove eCommerce for luxury retail.
- Retail: Kors buys Choo for $1.2B. Seeing consolidation in retail fashion with the Coach/Kate Spade $2.4B acquisition as well.
- Investing: looking for a 10x return. Do the simple compound interest math: 1.08³⁰ = 10x. That means if you can get an 8% return every year for 30 years, you'll 10x your investment. SpaceX and Snap have almost the same valuation. Which one would you rather be a part of?
- Business: a novel business model for emerging tech. There are 2 ways to make money when building emerging tech that becomes an eventuality: 1) Invest in it, wait and 2) Invent the IP, sue. In both cases, patience.
- Jobs: Amazon is hiring 50,000 people. Insanity.
- IR: Smart strategy; get Wall St comfortable with the notion revenue will be flat, then blow doors off in next quarter.
- Communication: WhatsApp has 1B DAUs.
- Ads: the Rock is the man.
- Cryptocurrency: great story from our friend Jen at Fortune. She's working on a big one right now, can't wait for it to hit newsstands.
- VC: we're a top writer.
- AI: StoryApp on the cover of wired, this time with a pic. A16Z links to the Limits of Deep Learning. Nothing to fear but a math text book.
- Robotics: gets more investment, but they still don't have a brain and central nervous system in software. Don't be silly. PROME's better.
- Bio: write a human genome from a text editor.
- Space: systems integration in space might be a gigantic business. This company is already a leader. The next iPhone might double as a space ship.
Why don't any schools teach emerging tech?
— Sean
Read The Rest
Page 52, 51, 50, 49, 48, 47, 46, 45, 44, 43, 42, 41, 40, 39, 38, 37, 36, 35, 34, 33, 32, 31, 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, 1
Humanizing Tech is a premium technological think tank for building humanity's future. It covers autonomous robotics, self-learning AI, superhuman augmentation, personal hedge funds, editable DNA, SAAS space platforms, personal power stations, and video as an app. It recently joined forces with The Mission. This newsletter is a peek inside the Editor's mind.
Diary of a Madman, Page 53 was originally published in Humanizing Tech on Medium, where people are continuing the conversation by highlighting and responding to this story.
from Stories by Sean Everett on Medium http://ift.tt/2wenAxp


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A closet cleanse is about more than decluttering. It's a chance to embrace chemical-free clothes and sustainable fashion.
Remember New Year? When you swore off wine and cake in favour of Elle Macpherson's green powder, and promised to detox negative energy, schedule daily meditations and step up your exercise regimen? Of course you do; you do it every year. But how often do we extend this thinking to our closets? Does your wardrobe need a detox?
"My definition of a toxic closet is one full of clothes I don't wear; items that just hang there, gathering metaphorical dust and making me feel guilty," says Courtney Sanders, co-founder of online sustainable fashion store Well Made Clothes. "Of course, it's important to know who made our clothes and what from. But consider that – according to Greenpeace, we buy 60 per cent more clothes than we did 18 years ago, and keep them for half as long – buying more mindfully is really important, too."
She says that the Vivienne Westwood approach ("buy less, choose well, make it last") has "the added bonus of making me feel good, and helps me curate a look I'm happy with". Think of it as decluttering the fashion mind.
"A good, old-fashioned" clear out is one of Vogue fashion editor Philippa Moroney's favourite things to do. "Take everything out, clean the surfaces so it's all fresh, then put back everything, in order, organised by skirts, pants, dresses, tops coats, blazers and so on," she advises. "I even arrange in colour order (yes, I know)."
Apart from the obvious satisfaction factor, it allows her to take stock. In the process, she usually rekindles a romance with a neglected garment. "Oh, the gems I've found reuniting with a long-lost favourite piece!" Restoring physical order also reduces the stress of the daily grind. "It helps me get dressed in the morning," she says. "No need to rummage around for something."
What to do with pieces that no longer pass muster? "On-sell," says Moroney. "I sell twice a year at markets and for bigger-ticket items use re-commerce sites like Vestiaire Collective. I love the idea that my much-loved items are given a second life." Some things she will never part with. "I have a small archive, including a jewelled black Prada top from the iconic spring/summer '14 collection, and my first Burberry trench coat, and I keep my handbags to hand down to my daughter."
Orsola de Castro, co-founder of Fashion Revolution, says hand-medowns are totally chic. She shares clothes with her daughters and son. "They love it. It makes us more creative." She also passes clothes on to friends and colleagues, who she knows will get excited about specific pieces. "And I never turf clothes out. When the seasons change, I use a rotational system to put them to sleep in the dark parts of my wardrobe, or in suitcases, and I always find new joy when I unpack them later."
One of Fashion Revolution's mantras: "Loved clothes last."
Adds de Castro: "If I do need to pass clothes on outside my circle, I donate intelligently – think what charities are looking for and when. For example, this London winter I know my local homeless charity is after good quality warm jumpers and coats. If passing on my clothes mindfully can do good, that's great. Problems arise when people dump stuff thoughtlessly on charities, which they then have to pay to landfill." Asked if she personally considers that other aspect of the toxic wardrobe: clothes and textiles produced with chemicals that can harm people and planet, she says: "Well, we all should! The fashion industry is famously polluting. Although I admit I often don't know what's in the things I wear, because I'm an upcycler and I collect so much vintage. God knows what I've worn from the 70s!"
"Nasty chemicals can be used to process, dye and transport fashion," says Melbourne designer Courtney Holm, who launched her ethical-eco basics label A.BCH in response. "Formaldehyde [used to keep fabrics wrinkle-free and prevent mildew forming during transport] is an example of a toxic chemical we may have no idea can sometimes be used in garment finishing. These chemicals can lurk in our wardrobes and can cause skin irritation and other health problems."
While the pesticides used in conventional cotton production might not have a direct impact on the wearer, they can have dreadful effects on farmers and the environment. Holm says making the switch to healthier fashion is easier than you might think. "Choosing GOTS-certified organic cotton is a great place to start."
Brands are becoming increasingly transparent about their materials and production processes, as customers start to ask more questions about provenance and healthfulness of their clothes. "Now is a wonderful time to switch to sustainable fashion," says de Castro. "There's so much information available today for you to make informed choices. Be curious, find out and do something!"
This article originally appeared in Vogue Australia's February 2019 issue.


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Socrates, Plato and Aristotle are the three best-known Greek philosophers of antiquity, representing the classical era of Greek philosophy. In succession, Socrates taught Plato, and Plato taught Aristotle. Each man formulated his own rhetorical argument style and hypotheses about the nature of knowledge to influence the next generation of thinking people. These incredibly important philosophers formed the backbone of higher education for hundreds of years, and their influences continue to this day in the field of philosophy. Three of the most important figures in the history of Western philosophy. You can't begin a study of world philosophy without talking about these philosophers.
Which one do you think is the most important and why?
Please feel free to share your thoughts!


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This timeline of Christian missions chronicles the global expansion of Christianity through a listing of the most significant missionary outreach events.
Earliest dates must all be considered approximate
Hanoi, Laos, Cambodia, Philippines, Thailand


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Scotland's latest outdoor snowsports season could continue into next month, says Ski-Scotland.
The organisation, which supports and promotes Scottish snowsports, said more snow had been forecast for mountain areas.
Scotland's mountain centres – The Lecht, Glenshee, Nevis Range, CairnGorm Mountain and Glencoe Mountain – have had frequent snowfalls this season.
In 2010, skiing was still possible at CairnGorm until midsummer in June.
Ski-Scotland said the mountain centres would stay open while conditions lasted and until numbers of customers "dwindled away".
Chairman Andy Meldrum, added: "Once spring does finally arrive with warm sun and daffodils blooming, people seem to believe there's no snow left for skiing or snowboarding.
"However, this really is the best time of year to come for a slide in the mountains with a much better chance of good overhead weather.
"It's also a really good time to learn, when the weather is kinder and slopes quieter."


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Visit Shipping & Returns and Terms of Use pages to learn about our policies
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In Clear Blue, Spoken's translucent frame is almost crystal-like in beauty. This full-rimmed, round lensed frame is a must-have for any fashionista seeking elegance in the urban setting.
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Color: Clear Blue; Size: S
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Love the thin frame shape and the two different colors!
Color: Clear Blue; Size: S
i'm in love! love the color and it's light weight . this is great if you have a small face . no regrets at all
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Still stylishly large and round looking on my petite face. I got a delicate eyeglass necklace and they go great together!
Enjoy two weeks to try out our frames.
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wine tasting
Barrels of Fun- Wine Education Tour
Barrels of Fun- Wine Education Tour
Duration:3 hours total
Includes:Drinks and Equipment
Languages:Offered in English
About your host
I truly believe wine appreciation is a lifelong learning experience, and that wine is for everyone! I just recently completed my Level 1 WSET certification, which means I love learning about and teaching others about wine. I've also worked in a few local tasting rooms. I am excited to provide you a judgement free and educational tasting experience.
What we'll do
A note from the Host: If our shown availability doesn't meet your needs, please message us and we'll try to schedule something! During your time with us we'll taste at 2 boutique, family owned, wineries in downtown Santa Barbara. You'll have the flexibility to either share tastings or do your own. Throughout our tour you'll learn about the different wine regions of California's central coast,…
What else you should know
Tasting Fees are not included. Plan on $15 per tasting per winery. You're more than welcome to share tastings. If there are other wineries you'd like to try, we are happy to replace or add a stop!
What I'll provide
Water bottles
Learning Materials
What to bring
Good walking shoes
Reading Glasses
Guest reviews
Navigation section for review pages
Where you'll be
We'll begin at August Ridge in historic La Arcada. They focus on Italian Wines grown in Paso Robles. We'll continue to Margerum in De La Guerra Plaza. Winemaker Doug Margerum is a pioneer for the Santa Barbara wine industry.
Keep these in mind
Cancellation policy
Any experience can be canceled and fully refunded within 24 hours of purchase.
Communication policy
Always communicate through Airbnb. To protect your payment, never transfer money or communicate outside of the Airbnb website or app.
Guest requirements
Up to 4 guests ages 18 and up can attend.
Government ID
You'll need to take a picture of yourself that matches the photo on your ID. This is so Airbnb can confirm who's actually going on the experience. You'll only have to do this once.
This experience includes alcohol. Only guests who meet the legal drinking age will be served alcoholic beverages.
More tips
Tasting Fees are not included. Plan on $15 per tasting per winery. You're more than welcome to share tastings. If there are other wineries you'd like to try, we are happy to replace or add a stop!
wine tasting
Barrels of Fun- Wine Education Tour
3 reviews
₹2,557 / person
3 reviews
₹2,557 / person


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Worst-case scenario: the UEd Goblin wipes the map and burns down your house.
Unreal Wiki talk:About
From Unreal Wiki, The Unreal Engine Documentation Site
Revision as of 11:15, 5 November 2015 by SeriousBarbie (Talk | contribs) (Error messages on pages, eg "Moon3")
Error messages on pages, eg "Moon3"
On visiting UE1:Moon3_(UT) I get the following error message:
Extension:DynamicPageList (DPL), version 3.0.7: Error: Too many categories! Maximum: 4. Help: increase $dplSettings['maxCategoryCount'] to specify more categories or set $dplSettings['allowUnlimitedCategories'] = true; for no limitation. (Set the variable in the wiki's LocalSettings.php configuration file.)
Browsing parent classes of "Moon3" creates error messages, too. --SeriousBarbie (talk) 10:15, 5 November 2015 (EST)