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Temecula - the Napa Valley of Southern California
Paula Gaston
After spending a day in Disneyland, our road trip continued south. We had about an hour drive to Temecula Valley, where we stopped to participate in a family wedding. What a great place for such an important day! And the wedding of course, was at one of the wineries in Temecula Wine Country.
Temecula is best known for it's wineries and the Old Town. It is conveniently located between Los Angeles and San Diego, only an hour drive from San Diego and a couple hours from L.A.. So some people call it the Napa Valley of Southern California. Since Temecula is a valley, it gets high temperatures during the day, but the weather cools off for the night time. This makes it a perfect location for growing wine grapes. In May and June mornings they sometimes get a marine layer spreading out to the valley cooling off the grapes. There are about 40 wineries in Temecula Wine Country.
In downtown Temecula the buildings date all the way to the 1890's. Today, they are full of restaurants, tasting rooms, antique stores and boutiques. Every year Temecula hosts a Balloon and Wine Festival and vintage car shows.
Our main event was at a winery called Europa Village. We enjoyed the wedding festivities and had so much fun! The actual ceremony was held at a beautiful spot right by the grape vines. I am not very familiar with the wines that Temecula produces, but I would think that they don't produce enough to be sold all over the country. That being said, one could find some really nice unique wines from here. Since I'm currently pregnant, I didn't have a chance to taste them but hopefully I can return later to drink some.
Temecula is a great little stop if you are passing by, but I woulnd't compare it to Napa Valley yet. Maybe someday...


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At TODAY we take care to recommend items we hope you'll enjoy! Just so you know, TODAY may get a small share of the revenue.Using interviews with specialists, online reviews and personal experience, TODAY editors, writers and experts take care to recommend items we really like and hope you'll enjoy! TODAY does have affiliate relationships with various online retailers. So, while every product is independently selected, if you buy something through our links, we may get a small share of the revenue.
Whoever said money can't buy you love has never met my new boyfriend.
Sure, he's not cheap. But as they say, you get what you pay for. He's sleek and sexy. He's tall, posh and handsome. He doesn't balk at performing mundane household tasks. In fact, he's in his element when cleaning floors, removing cat hair from couches and picking up tiny, deadly Lego pieces.
He needs little tender, loving care — just a little bit of attention in the form of a quick charge. He's flexible, going from long to short to something in between.
And he's got a name that's fitting: Dyson V8 Animal cordless vacuum.
Dyson V8 Animal Cordless Stick Vacuum Cleaner, $299 (normally $499), Amazon
First, a little background. Maintaining clean floors is my Achilles heel. Crumbs, my nemesis. Cat litter, my ongoing adversary. Dyson steps up, so I don't have to step on any of it. He sits with us at dinner, and after my son and his friends inevitably dump pasta and veggies and bread and chicken and whatever onto the floor, he comes out to do his thing. In seconds, the mess is gone.
Emptying him out is equally painless. You simply pull at the top handle, the bottom releases, and your trash is safely gone.
And just charge him in the morning, and he's ready for 40 minutes to serve your every cleaning need. He comes with extensions, which I've used to vacuum my dusty ceiling fan, and under my son's bed — a cesspool of discarded food wrappers and tiny shards from broken toys.
Dyson has replaced my former amour, the automated vacuum Roomba, who also was a great partner, until he wasn't. Suddenly, he would get stuck in the center of the room for no discernible reason. He'd be trapped under furniture. He stopped sucking up even basic clumps of cat hair. And then, something got stuck in his belly. It made a grating noise whenever I ran him. I took him apart to find it, but came up short, and now, he sits alone, unwanted, unloved, as Dyson has taken his place.
For more home recommendations, check out
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Dr. FU is a dynamic rock cover band known for its energetic stage shows and rock versions of hits from classic rock to current radio pop dance hits and rap. Dr. FU has been an institution in the DC area music scene since the late 90's and has played virtually every popular venue and event in the DC area such as Big Night DC, Celebrate Fairfax!, ShamrockFest, and Friday Night Live, the 9:30 Club, the Howard Theatre, the State Theatre, the Hamilton, the Clarendon Ballroom, the Gaylord National Resort, Nationals Park, RFK Stadium grounds, and FedEx Field.
Dr. FU also performs a full-costume 80's hair rock show under the name Herr Metal.
Herr Metal plays all the hair hits from the 80's and 90's with flowing locks, spandex, and an authentic stage show that looks and sounds reminiscent of a concert you would expect to see circa 1987. Herr Metal has played to thousands at festivals and venues in the DC area alongside national acts such as: Cheap Trick, Pat Benatar, Third Eye Blind, Good Charlotte, Bush, Cracker, Kongos, and Plain White T's.
Both Dr. FU and Herr Metal are available for private bookings, including weddings, corporate events, and private parties.
Drums & Vocals / Chris DeChiara
Guitar / Greg Gonzalez
Bass & Vocals / Rob Harris
Vocals / Kent Strang
Guitar & Vocals / Greg Yadzinski
News & Updates
30 Sept. - Join the FUs for our Halloween show at Whitlow's on Oct. 25! Get you costume ready now!
8 Sept. - FU killed it at Whitlow's last night! Here are the photos! Next up: FU & Herr Metal invade Westminster FallFest on 9/27!
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12 Aug. - Big gigs on the horizon! First: FU rocks Lansdowne on the Potomac Summer Concert Series on Aug. 16. Next, FU & Herr Metal Rock the Block on Aug 23!
Go back to school with Dr. FU at Whitlow's on Wilson! https://t.co/mx4qa6vg1w
Ballroom Blitz: ft. The Reflex and Herr Metal ticket giveaway on the Herr Metal Instagram! https://t.co/3IRqa5cjUP
Ticket giveaway on the Herr Metal Instagram! https://t.co/wUwsYBrInR


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President Pranab Mukherjee today arrived here on a two-day visit to Bhutan and was received by the King and his wife in a special gesture.
King Jigme Khesar Namgyel Wangchuck along with his wife turned up unexpectedly at the airport as a special gesture to receive Mukherjee, the first Indian head of state to visit to the country in 26 years.
Hundreds of school children were lined up along the way, holding Indian and Bhutanese flag.
During the visit, Mukherjee will hold meetings with Wangchuck and Prime Minister Tshering Tobgay besides other leaders to take bilateral ties to a new level.
Some agreements in education sector are likely to be signed during the trip.
The President is accompanied by a high-level delegation comprising Minister of State for Railways Manoj Sinha, Members of Parliament Mukhtar Abbas Naqvi, Anil Shirole, Mahendra Nath Pandey (all BJP) and Gaurav Gogoi (Congress), besides officials and representatives of a few educational and academic institutions.
Sources said as India is keen to revive the ancient Nalanda University, an agreement will be signed for seeking cooperation from Bhutan in this regard.
Mukherjee's visit to Bhutan comes nearly five months after Prime Minister Narendra Modi's trip to the country. It was Modi's first foreign visit as Prime Minister.
The meetings of the President with the King of Bhutan and the Bhutanese Prime Minister, who will call on him, will provide an opportunity to discuss all issues of mutual interest and ways of further strengthening close bilateral relations.
India shares a unique and special relationship with Bhutan nurtured by successive Kings of Bhutan and Indian leaders.


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August 7, 2012Technology and Innovation
Emerging Voices features contributions from scholars and practitioners highlighting new research, thinking, and approaches to development challenges. This article is from Nadia Oshry, Adam Bradlow, R…
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A Syrian refugee holding her child in the Turkish border town of Boynuegin. (Osman Orsal/courtesy Reuters) Two weeks ago the Obama administration unveiled a new policy for preventing and responding …
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The very tight race between Uhuru Kenyatta and his Jubilee Party and Raila Odinga and the National Super Alliance (NASA) reflects growing food insecurity that, in turn, is the product of drought, whi…
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July 6, 2017Donald Trump
In his major speech in Poland today, President Donald J. Trump pledged that the United States will work with its allies to defend "Western civilization" from "dire threats to our security and way of …


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EXIT is a puzzle game that requires pure logic rather than luck or dexterity. 100 levels that will blow your mind. The goal is seemingly simple: put all the balls into their corresponding target slots.
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When it is real, a wedding ceremony is a profound and mystical event. At the heart of a wedding ceremony is the celebration of a relationship's beauty and strength while two single people change into a single, united partnership. Your wedding ceremony honors and celebrates the love, hard work, commitment, compromises, and forgiveness that have supported your relationship this far; experiences that you will return to again and again as you travel through time together as individuals, the best of friends, lovers, and partners.
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Casual Labour - Security Officer
Marina Bay Sands Pte Ltd| Date Posted: 3-Oct-2019
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Job Nature:
Job Category:
'N' Levels / 'O' Levels, ITE/ NITEC/ Higher NITEC, 'A' Levels, Diploma, Bachelor's / Honours, Masters / PhD
Job Description
Summary of Key Responsibilities
- Maintain security by ensuring a safe and secure environment for guests and team members at Marina Bay Sands.
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Job Responsibilities
- Perform security functions at assigned posts in the non-gaming areas.
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Education & Certification
- At least 'N' Levels and above.
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- A team player.
- Able to handle stress and multi-task.
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Five OST to PST Converter Tools to Convert OST File to PST
No one can deny the fact that OST file corruption is common these days therefore people are finding the way out to deal with such issues. The most recommended solution is to convert OST file to PST. So I am going to tell you five most demanded OST to PST Converter Tools which has positive
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PARRY Locks for Stainless Steel Wall Cupboards
PARRY Locks for Stainless Steel Wall Cupboards is part of the range of quality accessories from Parry. These locks are designed to be fitted to Hinged Wall Cupboards : WCHSeries 450, 600 & 750 and Sliding Door Wall Cupboards: WCS Series 900, 1200, 1500 & 1800.
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PESHAWAR: The Khyber Pakhtunkhwa Wildlife Department has closed the partridges shooting season from Sunday last. The hunters were asked to abide by the wildlife hunting rules and regulations in letter and spirit. However, violators could be punished with fine and imprisonment, under the Khyber Pakhtunkhwa Wildlife Act and rules made there under, said a press release issued here on Monday.–Staff Reporter
Our Staff Reporter
February 09, 2016


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Bonide 024 Concentrate Neem Oil Insect Repellent, 16-Ounce
List Price:
Deal Price 12.19 USD
(Updated Feb 24 0:59 UTC)
See details on Amazon .
Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon.com at the time of purchase will apply to the purchase of this product.
(Deal Product)


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This author's biography has not yet been added to our database.
After escaping an abusive marriage, Lila Hayes never dreamed she'd fall into bed with a tall, dark and domineering man like Arthur. He's a stranger, he's cocky as hell, and…he seems to have emerged from the painting on her wall. From the second she feels his touch, Lila knows she's found the lover of her wildest fantasies.
Arthur of Sefyll is an ancient Druid, a man cursed for thousands of years to grant the wishes of those who summon him from his enchanted rest. He's had enough of serving mortal whims, until he spends a night satisfying Lila's every carnal fantasy and losing his heart in the process.
But soon, the new lovers' happiness is threatened by a monster from Lila's past and a horror from beyond the grave.
Now Arthur and Lila must convince sexy Sheriff Sam Walker to succumb to his desire for them both and help them form a mystical threesome. Wishes are no longer enough to keep Lila safe. Only the love of two special men can save her life — or maybe just as importantly, mend her heart.
Dr. Cecelia Barnes' research on blood diseases made vampire Julian Mansfield want to watch her. Her intelligence and spirit, not to mention the sparkle in her eyes, made him want to help her.
Julian planned to seduce her work — which endangers all vampires — out of her, but her strength and wit seduce him right back. Before he knows it he's changing his plans and starting a bloody, violent war against his old master in a desperate bid to save the life of the woman he's quickly realizing he can't live without.
As their passionate meeting turns into a full-blown love affair more intense than either of them expected, Julian is tortured by the knowledge that he must admit to Cecelia that he is a vampire, or lose her…but when she finds out he's been lying, will she want to stay?
Reader Advisory: This book contains a brief scene of light female/female sexual exploration.


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Hydradermie Facial £53 - 1 hour 15 minutes
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UW Forefront Suicide Prevention Program in the Schools
- Written by David B. Clark
Suicide is the second leading cause of death for youth ages10 to 24 in the state of Washington. On average, two young people in Washington state fall to suicide every week; 17 more are hospitalized for attempting to end their own lives. We live in a time when mental health awareness is at an all-time high but only because the torments of anxiety, depression, and addiction have skyrocketed. Thanks to legislation that was enacted in 2013, school safety plans got a much needed booster shot concerning mental health and suicide awareness. As the problem continued its steady push putting more kids at risk, it became vividly apparent that protocol concerning how to handle these daily emergencies in the classroom was as vital as knowing the location of a fire exit.
The University of Washington's Forefront Suicide Prevention in the Schools (FIS) was formed to support Washington high schools with the task of creating a comprehensive approach to mental health promotion and suicide prevention. The program utilizes on-going training and consultations to foster an environment that destigmatizes mental health issues. The model sets six-to-eight member multi-disciplinary teams of parents, administrators, counselors, and teachers to lead things like behavioral health and awareness weeks and peer-led trainings. The program, which runs for three years, is now in its second cohort of schools (2017-2020) while the first cohort wrapped concluding in 2018. Woodinville High School (WHS) was among 12 other schools that proudly participated in the first FIS cohort.
Theatre teacher and dean of students at WHS, Josh Butchart, was heavily involved in getting FIS involved at the high school. Butchart, who has been an educator for 15 years, shared that the school has seen a significant increase in students who are willing to talk about their struggles with suicide. He commented on students speaking up when they were worried about each other and not just themselves. "Students routinely bring their own mental health concerns to their counselors and they seem much more willing to share with their peers since we began FIS," said Butchart.
Butchart said that the mental health specialists for which Principal Kurt Criscione and the Parent Teacher Student Association "bent over backwards to find funding" has been an enormous help. He said that they were essential for developing the practices and protocols that WHS now uses. "Criscione realized the profound need we had for mental health specialists and has made that staffing and our work with FIS paramount over the past four years," said Butchart.
Butchart went on to explain how the framework FIS has standardized in their process really aided the WHS's staff becoming aligned with talking about suicide comprehensively. WHS has held an annual suicide prevention training for its staff each of the last four years. Furthermore, the support and guidance of FIS allowed for suicide prevention training to specific groups of students and parents over the last two years. "The model is both accessible and pragmatic, designed with educators in mind" said Butchart. The cohort of the schools—those 13 involved in the first round—worked as a network of resources, sharing best practices, ways to support, and even methods on how to respond to suicide or attempted suicide.
Butchart believes that the teacher training has established a positive culture of support and openness for the entire staff. "It has gotten all of the staff on board with being open to talking about suicide, how to handle a situation with a student who is thinking about suicide, and following protocols to best serve our students," said Butchart.
The American Foundation for Suicide Prevention has shown the suicide rate among youths has steadily risen in both the country and in the state of Washington. Moreover, Washington's youth suicide rate is slightly higher than the national average. The vision is that these better protocols, a focus on strengthening programs that will last, and a collective ability to destigmatize mental illness will allow those heartbreaking numbers to become only statistics of the past. The data providing reference to where we have come from and how much more work we have to do to better ensure more equitable mental health education and resources for the generations to come.


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2019 Education TrendsJan 24, 2019
2019 is here already! Let's take a look at what might be in store in education for the year ahead. What are the trends to be watching as we move through 2019?
Building a Foundation for School Readiness for Low-Income ChildrenJan 17, 2019
School readiness skills begin in early childhood. When parents work extra hours or come home too tired to read or play, children may not receive enough attention to develop the cognitive skills needed for school success.


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Bawean Island is an island located in the Java Sea, with an island area of almost 200 km2. Bawean Island is one of the islands in the district of Gresik, East Java, Indonesia. Its location is around 80 minute or around 120 km north of Gresik district. Bawean Island has many potential untouched tourism destinations, natural beauty of the mountains with dense tropical rainforests, lakes and waterfalls, to very exotic beaches.
Bawean Island has seven beautiful beaches that can be enjoyed by tourists, such as Noko Beach, Gili (East), Noko Selayar, Ria, Long Grave, Mayangkara and Tanjung Gang. Each beach certainly has a uniqueness and beauty that can spoil the eyes of the tourists. The island is also dubbed the island of the princess, the reason being that all male residents became nomads. This causes most of the Bawean population to be women.
All tourist destinations offered on this island are still very natural and awake, white sand lies on all its beaches, including small islands around it. Here tourists can also enjoy the sunrise and sunset from the corner of the island. Bawean Island has an amazing underwater beauty, no wonder if all the beaches on this island have snorkeling spots. And it has many beautiful coral reefs, one of which is a coral reef around the border between the villages of Kepuh Legundi and Gili Islands. These coral reefs are increasingly exotic with many ornamental fish and turtles swimming there, there are 10 species of fish that do not exist in other oceans in the world except on this island.
In addition to enjoying the underwater beauty, on this island, there is one place that is also often visited by tourists, namely captivity of protected animals of the Bawean deer (axis kuhlii). The deer breeding area is located in the west gebang pudakit, sangkapura district, about 10 km from Sangkapura with a distance of 30 minutes. Bawean deer are endemic animals whose population is increasingly scarce and endangered, currently the number of bawean deer is estimated to be 400 to 600.
For accommodation on the Bawean island, it is already available in a fairly complete manner, many resort-shaped inns have been built, so that tourists just choose according to the budget for the place to stay. Access to the Bawean island can be reached by fast boat or ferry, through the port in Lamongan or the port in Gresik tourists can go directly to the Bawean island, with a travel time of about 3.5 hours by fast boat, and 8 hours for the ferry.


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Geetanjali Laghate and Dr Heeshma Shah, Technical Services Department, Signet Chemical Corporation, Mumbai, give an insight of various excipients and strategies that can be used for solubility enhancement by using different techniques
The pharmaceutical industry is facing enormous challenges in formulating poorly soluble active pharmaceutical ingredients (APIs) including new chemical entities (NCE) which are approved and under development. These molecules possess poor physicochemical properties like low aqueous solubility and low permeability both of which lead to poor bioavailability [1,2]. Scientists are therefore focusing on developing formulation strategies for increasing the therapeutic effectiveness of these molecules via an appropriate selection of excipients. Various excipients and strategies that can be used for solubility enhancement by using different techniques are elaborated [3,4] .
Solvents / co-solvents
The addition of a water-miscible or partially miscible organic solvent /co-solvent, is one of the most common and effective ways to increase solubility of poorly soluble molecules which are generally weak electrolytes, highly crystalline and lipophilic in nature. Co-solvents act by decreasing the interfacial tension between aqueous solution and lipophilic solute to facilitate solubilisation[5]. Some co-solvents extensively used in marketed formulations are propylene glycol (Kollisolv PG), low molecular weight polyethylene glycols (Kollisolv PEG 300 and 400), polyoxyl castor oil derivatives (Kolliphor EL and ELP), glycerin, medium chain triglycerides (Kollisolv MCT 70), long chain triglycerides like corn oil and olive oil, dmimethyl sulfoxide, ethanol, etc. Although a simple and quick approach, precautions need to be taken while using co-solvents to avoid precipitation of the solute on exposure to aqueous media and biological fluids.
Solubilisers: Surface active agents or surfactants are amphiphilic molecules having a polar head group and non-polar tail. The head group can be cationic, anionic or non-ionic in nature. They function by lowering the surface tension and improve the dissolution of lipophilic, poorly soluble APIs. Beyond a specific concentration known as the critical micelle concentration (CMC), the surfactant molecules self assemble to form aggregates known as micelles. Drug molecules get entrapped within these micelles which in turn increases their solubility.
The CMC for most surfactants is very low. For non-ionic
surfactants it is in the range of 10-5 mol/L. The CMC is slightly higher for ionic surfactants and micelle formation is difficult due to electrostatic repulsion between the charged polar groups and is in the range of 10-3 mol/L. Non-ionic surfactants are the ones which are mostly used for formulation development. Notable examples found in marketed formulations are polyoxly 35 castor oil (Kolliphor EL), polyoxyl 40 hydrogenated castor oil (Kolliphor RH 40), polyoxyl-15-hydroxystearate (Kolliphor HS 15), Poloxamers (Kolliphor P 188, Kolliphor P 407 , Kolliphor P 124), D-alpha-tocopherol polyethylene glycol 1000 succinate (Kolliphor TPGS), Polysorbates (Kolliphor PS 60, Kolliphor Ps 80), sorbitan mono oleate (Span 60, Span 80), etc. Apart from facilitating dissolution by micellar solubilisation, surfactants also play an important role in stabilising suspensions, formation of micromulsions and self emulsifying drug delivery systems [6]. Microemulsions are thermodynamically stable, transparent, low viscosity, isotropic dispersions consisting of oil and water stabilised by an interfacial film of surfactant molecule in conjunction with a co-surfactant. Water soluble, water insoluble and amphiphilic drugs can be incorporated in these systems. Self emulsifying and self micoremulsifying drug delivery systems (SEDDS and SMEDDS) are isotropic solutions of oil and surfactant which form oil in water microemulsions on mild agitation in the presence of water. Poorly soluble drugs can be dissolved in the oil surfactant mixture which is known as a pre-concentrate. On oral administration they behave as microemulsion and enhance the bioavailability of the API. Examples of oils used in the formulation of microemulsions, SEDDS and SMEDDS are caprylic/capric triglycerides (Capryol), polyglycolysed glycerides (Labrafil and Labrasol), medium chain triglycerides, (Kollisolv MCT) etc. [7,8] These oils are used along with the surfactants listed above. Another way of enhancing the solubility of poorly soluble drugs is by formulation of liposomes. They are closed spherical vesicles composed of outer lipid bilayer membranes and an inner aqueous core with an overall diameter of < 100 microns. They can be produced from cholesterol, non-toxic surfactants, sphingolipids, long chain fatty acids and phospholipids like hydrogenated soya phosphatidiyl choline (HSPC), Distearoylglycero phosphoethanolamine (DSPE), Dipalmitoylglycerophosphoglycerol sodium salt (DPPG, Na), MPEG-ylated phospholipids like MPEG-DSPE [9,10].
To summarise, due to the ease of availability and relatively non-toxic nature as compared to organic co-solvents, solubilisers were and still are the most widely used excipients for solubility enhancement.
Complexation: Cyclodextrins are cyclic (a-1,4)-linked oligosaccharides of a-D-glucopyranose comprising of a hydrophobic central cavity to accommodate the drug molecule to form an inclusion complex and hydrophilic outer surface. They are classified as a, ß or ? corresponding to 6, 7 or 8 glucopyranose units. Out of these, ß-cyclodextrins (ß-CD) are widely preferred in the industry. They act by making the drug available at the surface of the biological membranes from where it partitions without interfering with the lipid bilayer thereby making the drug bioavailable. In addition to the natural cyclodextrins, two synthetic water soluble derivatives i.e. hydroxypropyl ß-cyclodextrin (HP ß-CD) and sulfobutylether- ß-cyclodextrin sodium salt have generated interest due to the advantages of greater solubility, tolerability and safety. Though ß-CD and HP ß-CD are less toxic as compared to surfactants and co-solvents, the limitation of this technique is that the drug needs to have the ability to form complexes which may not be possible in some cases. [11,12]
Solid dispersions: The stable form of a drug molecule is crystalline in nature and poses problems in solubilisation due to its high lattice energy. On the other hand, the disorderly/irregular amorphous form offers an advantage over crystalline forms with respect to solubility inspite of its poor physical and chemical stability. New techniques that render the amorphous form stable are becoming increasingly popular; can be achieved either by making the API amorphous or by formulating an amorphous delivery system. For both approaches, solid dispersion technology is used extensively. These are systems where one component is homogenously dispersed in a carrier matrix (which is usually polymeric and often amorphous) and when the whole system appears to be in a solid state. They can be formulated primarily by two methods viz. melting method and solvent evaporation by using processes like spray drying, spray congealing, spray layering and hot melt extrusion among others. Amorphous solid dispersions can be stabilised if the 'freezing effect' is sufficient due to a high glass transition temperature of the system or, better, by interaction such as hydrogen bonding formation between the dispersed drug and the polymeric or amorphous carrier. When exposed to the aqueous GI environment these systems produce supersaturated solutions to achieve optimum release. Commonly used matrix formers are homopolymers, copolymers, amphiphilic copolymers. These may be used in combination with solubilisers and plasticisers. Notable examples of matrix formers are polyvinyl pyrrolidone- poly vinyl acetate (Kollidon VA 64), Hypromellose acetate succinate (AQOAT), Hypromellose (Pharmacoat), povidones (Kollidon 30, Kollidon 90F), polyvinyl caprolactum-polyvinyl acetate-polyethylene glycol graft co-polymer (Soluplus), Polymethyl methacrylates. These polymers can be used alone or in combination with one or more surfactants like Poloxamers (Kolliphor P 188, Kolliphor P 407), polyethylene glycols (Kollisolv PEG 300 and 400), and Vitamin E polyethylene glycol succinate (Kolliphor TPGS). The concept of solid dispersions has been applied to many marketed formulations and has resulted in clinical benefits by increasing the bioavailability poorly soluble API [13,14,15].
Understanding the rate limiting step in oral absorption is important in the selection of appropriate excipients and designing formulation approaches which are simple and cost effective. A combination of good science and good judgment help in overcoming the challenge posed by poorly soluble drugs and meeting stringent development timelines.
1. Shah SS, et al. Preclinical Formulations: Insight, Strategies, and Practical Considerations. AAPS PharmSciTech 2004; 15(5); 1307-1323.
2. Kawabata Y, et al. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. International Journal of Pharmaceutics 2011; 420; 1– 10.
3. Herting MG, et al. Investigation of solubilization efficacy using a high throughput robot. In: Reintjes T, ed. Solubility Enhancement with BASF Polymers, Germany: BASF SE, 2011: 53-63.
4. Narang A. Problem dissolved? – ensuring improved bioavailability. World Pharmaceutical Frontiers. 2014.
5. Kalepu S, et al. Insoluble drug delivery strategies: review of recent advances and business prospect. Acta Pharmaceutica Sinica B 2015; 5(5); 442-453.
6. Koltzenburg S. Formulation of problem drugs- and they are all problem drugs. In: Reintjes T, ed. Solubility Enhancement with BASF Polymers, Germany: BASF SE, 2011: 9-26.
7. Bajaj H, et al. Bioavailability enhancement: A review. International Journal of Pharma and Bio Sciences 2011; 2(2); 202-214.
8. Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharmaceutical Research 2004; 21(2); 201-229.
9. Jing L, et al. Review on phospholipids and their main applications in drug delivery systems. Asian Journal of Pharmaceutical Sciences 2015; 10; 81-98.
10. Technical Brochure of Synthetic phospholipids and other synthetic lipids. Switzerland: Corden Pharma Switzerland LLC, 2011.
11. Rasheed A, et al. Cyclodextrins as drug carrier molecule: a review. Scientia Pharmaceutica 2008; 76; 567-598.
12. Technical Brochure of Kleptose: Betacyclodextrins and hydroxypropyl betacyclodextrins. France: Roquette Freres S.A, 2006.
13. Huang Y, et al. Fundamental aspects of solid dispersion technology for poorly soluble drugs. Acta Pharmaceutica Sinica B 2014; 4(1); 18-25.
14. Introduction to solid dispersions. In: Kotler K, Karl M, Gryczke A, eds. Hot Melt Extrusion with BASF Polymers, Germany: BASF SE, 2012: 10-18.
15. Introduction to hot melt extrusion for pharmaceuticals. In: Kotler K, Karl M, Gryczke A, eds. Hot Melt Extrusion with BASF Polymers, Germany: BASF SE, 2012: 19-34.


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Veterinarians Ernie Ward & Cyndie Courtney with veterinary technician Beckie Mossor confront whether pursuing a degree in veterinary healthcare is a good or bad idea; how staggering student debt impacts our profession both financially & emotionally; potential solutions for excessive debt, escalating college tuition, and imbalanced veterinary supply & demand. The hosts share why they joined the veterinary profession and offer some of their best personal advice.
Podcast: How to Host an Open House or Pet Health Fair with Laura Ward, MA
Hosts Dr. Ernie Ward & Beckie Mossor, RVT are joined by practice owner & hospital administrator, Laura Ward to discuss giving back to your community. We review how to plan and pull off an Open House, creating an awesome Pet Health Fair, and why the Wards believe giving back to your community is good for team building and practice building. If you're looking for ideas to jumpstart your clinic's civic participation, this episode is chock full of ideas and inspiration.
Podcast: Title Change to Veterinary Nurse with NAVTA's Julie Legred, CVT
The title "veterinary technician" is moving out! This week Dr. Ernie Ward and Beckie Mossor are joined by the National Association of Veterinary Technicians in America (NAVTA) Executive Director, Julie Legred, CVT, while Dr. Cyndie continues to enjoy (?) maternity leave. Julie discusses the recent official announcement of the name change from "veterinary technician" to "veterinary nurse," how the credentialing and transition will occur, and a new support staff training program from NAVTA. The trio have a wide-ranging conversation on finding happiness and meaning in the profession, what's the best advice for new colleagues, and how Julie finds balance with a husband, four sons, managing a HUGE swine business in Minnesota, and changing the world.
Podcast: Pet Loss - Grief, Clients, and Our Stories
This week's podcast touches on an important and highly emotional topic: Pet Loss. Listen in as Dr. Ernie Ward shares his recent loss of his beloved dog, Sandy, how his family is dealing with the aftermath. The team talks about grief in both veterinary professionals and clients, why grieving for pets is so intense, what "grief disenfranchisement" is all about, and how we can better understand and help our colleagues and clients as they confront the death of a pet. Share your own stories and experiences in the comments below or send us a private message.


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Thu., April 2, 2015, 1:12 p.m.
On The Waterfront …
... Greg Lee and I took what should be our last stroll on the "closed" Dike Road during the noon time. The Dike Road is scheduled to open Friday. Justin Kimberling was still busy with his backhoe. And there were some trucks, pickups and another piece of heavy equipment in use. But the work on the levee sides appeared to be complete. You'll be impressed with the smooth contour, the many new paths leading down to the water, and the more open view. Some of you, I suspect, will be shocked by the open view, especially along the Spokane River. But some might be pleasantly shocked re: the view. As we were walking today, the southerly wind was whipping off Lake Coeur d'Alene, chilling us. "It wouldn't be so cold," Greg quipped, "if there were more trees to block the wind." We laughed.
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KSI Member Spotlight – KSI K146 HAVOC, CD
Check in with the News Team to learn about KSI K146 HAVOC!
Check in with the News Team to learn about KSI K146 HAVOC!
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Confused about what the term "Clan Ops" means? Learn more here!
KSI Pantsir 7 explains the differences between a clan and a community, tune in to learn!
After almost three years of Impy's LeaderShop being on hiatus, it's back! This week: Communication.
Communication is important in every aspect of life, especially within KSI.
KSI Ascend 7 shares some of his history and a few pieces of advice for up-and-coming leaders of KSI.
KSI True 7 shares five qualities she believes all great leaders have.
KSI True 7 gives us her thoughts on the importance of recruiting.
With Legion about to drop, did Blizzard ruin the fun of playing as a Warlock?
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The X-Lite brand is committed to maintaining the highest standards in manufacturing and safety. Our brand is recognized worldwide. At X-Lite Corporation, we maintain that brand standard in every aspect of our business. Our staff of professionals work closely with our customers to understand their requirements. We listen to what the customer wants and needs. Our process is extremely flexible giving you the widest possible configurations to meet all your needs. At X-Lite Corporation we are committed to your success.
Commitment to Quality
The foundation of our success is our employees. Their commitment to continuous improvement and meeting the customer's expectations provides a basis for achieving our quality objectives. We strive to be a leader in the industry in terms of product quality and value, and we are completely committed to delivering products that meet contract specifications and our customer's requirements. Every aspect of our process is subject to our highest level of quality control. We continually review and revise our processes and make adjustments that ensure our quality benchmarks are maintained.
Commitment to Environment
Our commitment to the environment has guided us to continually strive to reduce our already minimized waste in our manufacturing process. We offer more environmentally friendly and sustainable products and strive to continually reduce our carbon footprint. We are constantly working with our suppliers to help find ways to reduce environmental impact. By offering re-fillable lighters, we help divert lighters from our landfills. Offering more re-fillable lighters helps greatly minimize the environmental impact to our environment. Our packaging is developed to maximize product per each shipment, minimizing the carbon footprint.
Warehouse Locations Across Canada
Our shipping and receiving department is committed to "just-in time" delivery. With over 25 years of shipping experience, our staff has a superior track record and the knowledge to make sure your deliveries make it on time. To better serve our customers, we maintain three warehouse locations across Canada. These strategic locations enable us to successfully ship across Canada and the U.S.A.
We also service clients in Europe, South Pacific and the Pacific Rim countries.
The X-Lite range combines modern design and state-of-the-art production technology at a higher quality level than the latest safety standard. Besides the high-quality material POM, which can withstand temperatures over 75°C and all drop tests, the safety cap ensures a maximum of safety. Above all, the safety flame based on the newly introduced membrane technology, guarantees superb customer satisfaction. The newly developed and patented CR system Gas Stop avoids any unintended gas leakage as with similar products in the market and ensures an even longer lifetime.
The fully automatic production processes guarantee an equally high production standard as in other automatic production plants; the intensive control mechanisms guarantee a consumer product with optimum safety and customer satisfaction.
- Specialist in the lighter industry for more than 19 years;
- ISO9001, ISO14001 and GB/T28001-2001 Certified;
- Quality guaranteed by advanced equipment and experienced staff;
- Four production facilities, more than 200 engineers and 400 technicians;
- The products passed ISO9994:2008 and with GS/SG/ASTM/CPSC certificate;
- Holds numerous North American patents;
- OEM capabilities


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Dave's presentation at the Spring '17 Sales & Retention Convention focused on the tour and closing more sales. He talked about looking for objections when there sometimes aren't any. Price is regularly seen as an objection but there are many ways around this, such as asking your prospect to give you their daily or weekly budget, which will often exceed your prices.
92% of consumers research lifestyle choice product such as gym membership online (Internet Retailing Magazine), so most of your prospects will know about you already, and will know your prices, if you publish them.
This session also covered selling the benefits of the club, but specifically tailored to the prospect's needs. Talk to the member about HUG (History, Usage and Goals), and try to sell something bigger than. The tour also needs to be personalised, and you should build value into the tour, and always link the tour back to the goals. If you run a great tour, as Dave demonstrated, you'll not have any objections to be handled at the end, your prospects will just sign up.


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Must have gadget
Took me back to child hood dream of flying together with my iPhone. Designed my own airplane to fly. Tons of fun with my nephew.
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