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Do you need to find a builder for your new construction Project in South Africa?
There are many construction companies in South Africa willing to take part in your dreamed house project. Home builders will be in charge of making your ideas and needs take form, so a sourceful dialogue and a good relationship during the process are vital to make your dreams come true. You will also find master builders for your maintenance needs or other projects.
Infoisinfo offers you a list with the best building services in South Africa as well as comments and valorations to help you in the search.
How to choose the right builders for your new home in South Africa
In Infoisinfo we know how stresful building a new house may be and we've prepared a little guide to help you when choosing among all the building companies in South Africa.
- What do you need?: as a first step you need to have a completed and specific idea of what you want and how you want it. The key to success is to be very specific when telling your needs to the builder. On the other hand it is important that you give him some freedom to work in the project, so a good idea woul be to prepare a brief where you include everything you want the new-home builders to know.
- The builders: check whether they are registered builders or not as well as warranty service and insurance.
- Design: if your tastes ar very specific, maybe you should count on custom home builders in South Africa to be fully satisfied with the result.
- Price, what is included?: you might be prone to hire the cheapest service you find, but it is vital to strike a balance between price and the services offered. Maybe a cheap service will turn out expensive if you dont' pay attention to what it incluedes and you have yo hire other services afterwards. For example, bare in mind whether you want them to remove waste or not. Try to get a global bill where all building material is clearly included in the price.
- Visit of a similar project: most of the construction builders in South Africa will let you see some of their last projects so you can have a better idea about their work. When visiting other houses, seek for signs of quality materials.
- References: ask for advice and look for reviews. Recommended builders are surely good builders.
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Patio Enclosure Builder - South Africa
1 - DG Construction - Vanderbijlpark
Unit 6 Nevada, Nikkel Street, Ce 2. Vanderbijlpark. Gauteng. 1911
No matter how challenging or what the size of the building project is, at DG Construction we pride ourselves on the fact webuild safe, quality structures, on time and within your…
2 - TOMECO (PTY)LTD - Bushbuckridge
Ratanang Trust, Green Valley. Bushbuckridge. Mpumalanga. 1370
WHO ARE WE? We are one stop shop when it comes to home building, and providing you with quality and presentable housing you can take pride on. Tomeco consists of a group of workmen…
3 - JP-Construction Overberg - Kleinmond
James Road, Pringle Bay. Kleinmond. Western Cape. 7196
JP Construction is a building contractor and construction company specializing in residential construction and holiday homes within the Overberg and Helderberg area. We focus…
4 - HBC Constructions - Hermanus
18 Krintang Sngl, Onrus River. Hermanus. Western Cape. 7201
Builders Hermanus, Vermont, Onrus, Gansbaai, Kleinmond, Pringle Bay, Betty's Bay, Rooi Els. We are NHBRC registered building contractors. For more than 25 years Hennie Bothma…
5 - Quality Sandblasting and Construction - Nelspruit
17A, Christie Crescent. Nelspruit. Mpumalanga. 1200
The company was established to provide the industry with a Sandblasting, recoating and industrial coating service. Additional services include new construction, maintenance,…
6 - Empire Premium Construction - Giyani
Giyani Section F 763, Giyani East. Giyani. Limpopo. 0826
Empire Premiums is a black owned company established in south Africa. the company is registered as a close corporation. Empire Premiums is a renowned company with sophiscated…
7 - Design Ventures RSA - Cape Town
19 Andrag Road, Vierlanden, Durbanville, 7550., Durbanville. Cape Town. Western Cape. 7550
Fast, friendly, and fully functional, our professional Home ImprovementCompany is well renowned throughout the Northern Suburbs of Cape Town.Our team is up for every job, managing…
8 - Gustine Development Investment cc - Nelspruit
26 bester street, Nelspruit Ext. Nelspruit. Mpumalanga. 1200
Gustine Development Investment cc was born out of keenness and dedication in construction. Currently the shareholding in Gustine Development Investment cc is 100% Black African Owned.…
9 - Donnelly Home Maintenance - Hermanus
Vermont. Hermanus. Western Cape. 7201
No job is too big or too small so whether you want a tap washer replaced or a water tank installed or a garage conversion or home extension built we are the people to call. Here…
10 - Turbo Glass - Johannesburg
Southern Africa. Johannesburg. Gauteng. 1854
Based in Zimbabwe, we export our boats and products to the far reaches of South Africa and will be happy to help with and boat sales or queries you may have. We manufacture, repair…
JAMJOHN CONSTRUCTION - Rustenburg
17986 EXT 8, Boitekong. Rustenburg. North West. 0308
Mechanical WorksOUR PRODUCT OFFERING Electrical Installation Jamjohn Construction services include design, reporting and evaluating emergency generator upgrades, high voltage and…
Helderberg Painting Renovating Construction - Cape Town
40 Algoa Street, Strand. Cape Town. Western Cape. 7140
HPR Construction -For All Your BUILDING & PAINTING Solutions, Construction & Building Contractors, New Homes, Renovations, Additions, Concrete Decking, Boundary Brick and Block Walls,…
East Rand Steel Construction - Boksburg
6 Paul kruger street, Boksburg East. Boksburg. Gauteng. 1459
STEEL STRUCTURES EASTRAND 0739990190, www.stimteam.co.za The region extends from Germiston in the west to Springs in the east, and south down to Nigel, and includes the towns of…
TG CONSTRUCTION GROUP - Midrand
696 Kite Street, Rabie Ridge. Midrand. Gauteng. 1685
At TG Construction Group we are dedicated to providing infrastructure and building solutions for tomorrow's world. We combine creative planning, design and construction with…
Cosy Cabins - Pretoria
72 Ouklipmuur avenue Willow Park Manor. Pretoria. Gauteng. 0186
Cosy Cabins manufactures & sells quality Timber huts, Wooden decks and more and also offer relocation and restoration services.There is no job to big or to small, Servants quarters…
UKASA Construction - Cape Town
Jefferson Road, Noordhoek. Cape Town. Western Cape. 7985
Cape Town based Residential & Commercial Building contractors, UKASA are geared to handle all bespoke building requirements.Our vast experience in the construction arena allows us to…
Hu Art Cape Province CC - Kleinmond
67 Main Road, Palmiet. Kleinmond. Western Cape. 7195
We specialise in the building of superb upmarket homes in the Overberg region. We do not utilise sub-contractors outside of our infra-structure, thereby ensuring continuous excellence…
Construction South Africa - Durban
837 Afreedom Road, Booth Aansluiting. Durban. Kwazulu Natal. 4170
Construction Company South Africa Based in Durban Reserve and Eugene Trading Enterprise is a Magabheni, Durban, Kwazulu Natal primarily based South African Construction and…
Malverns Projects (Pty) Ltd - Pretoria
430 Main Street, Waterkloof. Pretoria. Gauteng. 0181
Tel:0127727834 Cell:0810068753 E:firstname.lastname@example.com Do you need a home that defines you? Call Our talented craftsman and knowledgeable staff are committed to giving you…
GDS Costruction - Pretoria
c/o Alwyn and Waloo road, Pretoria North. Pretoria. Gauteng. 0001
GDS Construction is based in Pretoria. Known as an industry leader with more than 10 years' experience in the construction of concrete slabs and raft foundations we deliver on projects…
TECUWAY (PTY) LTD - Rustenburg
35 Kwartelsingel, Safari Gardens. Rustenburg. North West. 0300
We specialize in Underpinning of buildings. We do green building. We are always on the lookout for new business opportunities and new inventions. Our Company is based on Love for the…
Steel Workshop Warehouse-Xinguangzheng Steel Structure Co., Ltd. - Pretoria
Paul Kruger Street. Pretoria. Gauteng. 0002
Founded in 1996, prefab house and container house with ISO9001:2008, aircraft hangar, steel structure poultry house, storage warehouse shed, steel structure buildings, steel…
DB Building Projects (pty) ltd - Edenvale
4th Avenue. Edenvale. Gauteng. 1610
We take pride in our work and we work with the client so if there is anything the client requires, we will do it. Get a FREE quote today. For all your building requirements. For…
Rapid Repairs & Renovations - Roodepoort
169 Pruimbos ave. Roodepoort. Gauteng. 1709
Rapid Repairs & Renovations' inception into the building, maintenance and renovations industry commenced in 2004, with its Director, Brett Vee being a fully qualified Real Estate Agent…
Builders Cape Town - Cape Town
26 Alpha Street, Hoogstede, Brackenfell. Cape Town. Western Cape. 7560
Your house sure is valuable to you but if you are planning on selling it, you might need to check out the possible home improvements you can do to add more value to it in order to get…


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With the majority of the various aides being touted as the best in the business picking the correct manual for games wagering can be a test. There are truly several these games guides accessible in print and on the Internet making it hard to tell which ones are going to really enable you to figure out how to wager on games with a generally high possibility of accomplishment. This is on the grounds that for each one that is elegantly composed by somebody who comprehends what they are doing there are in any event a hundred composed by individuals who do not understand what they are doing.
First What Not to Expect from a Guide to Sports Betting
Before you can quit fooling around about searching for a manual for games wagering you have to comprehend what you ought not anticipate from the guide. Any guide that claims that you will wind up well off in only half a month ought to be dodged as even the individuals who have really gotten rich wagering on games will disclose to you it requires investment to transform your little speculation into a fat ledger.
Most aides that are composed by expert punters will reveal to you that you can get rich with the assistance of their guide, in the meantime they will be straightforward and disclose to you that it will require some investment and exertion on your part. When you move beyond the ones that guarantee to have the option to make you a medium-term tycoon you can begin looking all the more truly at the ones remaining over.
What You Should Expect from a Guide to Sports Betting
In the event that you will put your well deserved dollars in a manual for 안전놀이터 games wagering you reserve an option to hope to receive something as an end-result of your speculation. The one thing that you ought to hope to escape any games wagering aide is instruction. They are not going to reveal to you which groups to pick for the Superbowl or the World Series, while numerous punters have a thought who may make it the whole distance they are not going to offer that data toward the start of the period as it would all be able to change in a matter of seconds.
What a decent quality manual for games wagering that is composed by one of the best punters will let you know is what to look like at the insights and utilize their formulae to make instructed wagers that depend on the data in the guide. This implies the framework portrayed in the book ought to be precisely the same one the writer utilizes and has a demonstrated reputation of accomplishment. For whatever length of time that you stick to aides composed by surely understood fruitful punters your chances of figuring out how to make cash wagering on games are much better than attempting to make sense of everything without anyone else.

subset: commoncrawl


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Anglers have had a big week on beaches and offshore
There were some good seas and some great fishing to go with it this week, as many anglers hit the water in search of a feed or just some fun.
All the action was offshore and the beaches though, as the rivers fished tough in the estuaries.
School tuna have made a welcome return to both Warrnambool and Port Fairy.
Many anglers have been getting stuck into these awesome, fighting rod rattlers this past week with some like Peter Kavanagh and his mate Jonesy bagging quickly.
These boys were bagged out in 20 minutes from when they started fishing, which is incredible. Sam Powell, Ash Jacob and Chloe Dance all caught fish on Sunday, getting 11 hook ups and releasing the majority after tagging them. Ben McDonald and Jeff Dimech caught multiple fish on Saturday while casting top water stick baits into the feeding packs of fish, pushing bait balls high in the water column.
The reason for them being back is anyone's guess, but a few people I've spoken to have put it down to currents and the amount of red bait that's out there.
This is the same bait that kept the big barrel tuna at Portland for the past few months, so we could see some big fish come into our own ports soon.
Most anglers are trolling shallow diving minnows such as the Zerek Speed Donkeys and Halco Lazer Pros or small skirts like the Pakula Uzis and Fluzis in whites and purples.
But don't think that there is only tuna out there, as other anglers have focused their efforts on the bottom fish and have been rewarded with some great captures.
Isaac Ferguson sent us a picture of a nice gummy he caught on squid, which was one of many sharks caught that day.
There are some nice pan-sized pinkies in closer around Killarney and surrounds and the odd whiting also. At this time of year, the numbers of whiting really thin out, but the size of fish usually increases. So when you find them, they should be a good size.
If your taste buds need a bit of a wake-up call and you love eating crayfish, there's some good crays being taken by fisherman diving and drop-netting along the coast. Remember that you can only take the males, as the females have a closed season until November 15.
If you're unsure of how to find out, put them back as there's a hefty fine if you get it wrong. Tags are still required to be placed on the horns of the cray five minutes after getting it on board or 50m from the bank of where it was caught.
There's been some more action off the beaches this past week, with some good captures of salmon for those spinning for them.
Reports are coming in that you can see the schools moving up and down the beach, which makes it easier to target - especially while casting metals at them. If you're new to that style of fishing, a 9ft graphite rod and a 3000-4000 reel spooled with 20lb braid and a 20lb leader is ideal.
The longer rod gives you more control of your line in the swell and a longer cast, as its used like a catapult to heave out the lure with minimal effort. The 35-65g metals have been the pick, with a set of BKK ranger assist hooks replacing the trebles to give them that bit more attracting appeal.
Best places to look have been East Beach at Port Fairy and Killarney.
Try fishing around the change of the ride, whether it be the top or the bottom of the tide, as long as there is some sort of movement.
The estuaries have seem to gone quiet this week, especially the Hopkins where I know of a few anglers who didn't get a bite for a full day's fishing.
It's not uncommon this time of year, as the water really cools down and makes the fish a bit doughy.
Soft baits such as cut mullet, shrimp and glassies are the pick of baits in the winter. There has been some nice estuary perch being caught by Luke and Jedd after dark on soft plastics.
The Gercovich boys headed over to Nelson for a day trip on Friday after getting some live mullet. They caught one small mulloway about 55cm and lost a big one on a livie with the leader breaking between the treble and main hook.
Some nice fish have still been caught by the dedicated ones who put in a lot of time and effort getting the right bait. The fish have spread right out from the Caves all the way to the bottom, so chances of getting one are pretty high still - you've just got to persist.
There's still some nice trout being landed by anglers walking the banks along the Hopkins and Merri while casting shallow hard bodies and soft plastics.
Any sort of lure in the 5cm-11cm will get the interest of trout this time of year, but the most popular has been the perch and brook trout in the F7s Rapala.
If you're wanting to cast soft plastics, the Westin Shad Teez and Berkley T Tails in black gold are definitely worth a shot.
Unfortunately, with some strong winds hitting us this weekend, I can't see anyone being able to get offshore. It might be a quiet week coming up.
Until next week, tight lines and best of luck.


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- Manage the day-to-day running of projects from concept through to completion.
- Work alongside other engineers in the Practice and provide guidance to our Technicians as required.
- Attend site at various stages of each project.
- Attend design team meetings as required.
- Liaise with other members of the design team, effectively communicating design requirements.
- The production of technical drawings, either via hand sketches or by AutoCad drawings produced by our in-house Technicians.
- Manage time spent on projects to comply with the fee proposal.
- Attend any relevant training and CPD courses to support your role.
Working hours
Working hours are usually 8:45am to 17:15pm, Monday to Friday, with some occasional evening and weekend work where necessary
The work is office-based with occasional visits to construction sites in order to visit other professionals and clients, or to measure progress of a building project.
Degree level qualification in Structural/Civil Engineering or equivalent experience in the role.
- Competent in the design of steel, concrete, timber and masonry to British Standards of Eurocodes
- Experienced in AutoCad and design software, such as Tekla Structural Designer, CADS 3D, etc.
- Good analytical and problem-solving skills
- Strong mathematical ability
- Computer literacy
- Three-dimensional conceptual skills
- Excellent oral and written communication skills
- Diagrammatic skills
- The ability to work as part of a team
- Attention to detail
- The ability to liaise well with professionals from other disciplines
- An interest in the design and structure of buildings.


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03 Oct 2018
Cara Delevingne made a surprise catwalk comeback appearing in the Balmain show at Paris Fashion Week.
The model wore a futuristic warrior look designer by creative director Olivier Rousteing.
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A web site is highly important for any company over these modern days. No matter this agreement segment the business enterprise belongs to, it needs an internet site for surviving the onslaught of cut-throat competition. An internet site makes communications easy between a customer and business. It does not take first introduction of your business to the online audience helping a small business establish online identity and reputation. The need for developing a website has paved the way to the emergence of the thought of website design and development. A powerful web page design and development strategy leads to the development of an impactful website.
Website design. Designing an internet site implies designing that part of your web site that is utilized by the customers can use. It provides concepts like the appearance in the site, functionality, navigation etc. It emphasizes on making things simple for online visitors.
Website development. Web design is always that part which remains hidden from your viewers. Oahu is the back-end such as programming and interaction required for efficient functioning from the website. Website design helps to ensure that your website is working effectively and in addition involves solving any problems that may arise through the use or repair off the website.
After you have decided to create a website to your business, you have to first get yourself a domain name registered for the website. Url of your website is different and it must have appropriate keywords linked to your industry. Following are the three kinds of websites.
1. E-commerce website
2. Message boards and portals
3. Corporate or business website
After selecting a website name, you have to proceed to decide the website you want to have. E-commerce websites are generally useful for selling online. Corporate or business websites are widely-used to disseminate information. Depending on your needs it is possible to decide on the sort of website you need. After deciding all the above things, you have to begin the world wide web development process. It commences using a requirement analysis then Sitemap must be developed to design the navigation as well as the appearance of the web site.
If you use customized templates, graphic designing, and image editing, you are able to design principle appearance of your web site. A database should be designed and developed to enable you to upload content and images aimed at your website. The very last phase of web design and development includes lab testing. This is accomplished to spot bugs in the website and rectify them prior to site is intended for viewers.
If you are not a technical person but still are thinking about creating a website on your business, it can be perfectly fine. There are numerous of companies offering web designing and development. These people have a team of professional and experienced web designers and developers who work responsibly to provide an ideal website that helps you attain your organization goals.
Check out about web design galway please visit internet page: click here.


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text:
They have no testimonials
Dog(s), Cat(s), Horse/Donkey(s), Other animal(s)
They don't have a police check
From: 3 November 2019
Until: 2 September 2020
Not stated
They don't have referees/references
Hello, My name is Monica from Washington State. I am a very friendly caring person, who enjoys helping others, I like to be kept busy, and I am naturally calm. I try hard to be always open and honest because I truly believe that honesty builds trust. I value health more than appearance, and my only addiction is caffeine. I love to make new friends, and to me, animals, nature, and friends make life more pleasing.
I want house sitter because it will allow me to experience places from a resident's perspective. I am looking for a place to settle down, and house sitting will help me to find that perfect place! Of course, isn't just this. I want to make new friends, be around animals, learn a lot about people, and customs.
I know how to take care of a house. I always house sitter my sister's house when she was traveling. I also have experience with animals.
I am an animal lover who is studying to become a Veterinary Assistant. I'm clean and organized, and I will keep a daily and weekly schedule for your pets and the house. I am reliable, also I'm respectful of your home, I will treat it as if it was mine.
United States
From: 3 November 2019
Until: 2 September 2020
They don't charge for house sitting services
MindMyHouse member since 2019
You need to be logged in to see this house sitters' references.


text:
UK Men's Basketball
Stanford leans on veteran Fields
CANCUN, Mexico — Kentucky assistant coaches John Robic and Rod Strickland, plus assistant director of basketball operations Tony Delk watched Stanford beat Virginia 57-52 Tuesday night in the Cancun Challenge semifinals.
No doubt Landry Fields figured large in their assessment of Stanford (3-2), UK's foe in Wednesday night's finals.
Fields scored 25 points, grabbed 13 rebounds and made three steals — all game highs.
"He's one of the best players in the country," Stanford Coach Johnny Dawkins said. "I think he showed it tonight."
Fields, a 6-foot-7 wing, is Stanford's lone returning senior starter from a team that went 20-14 last season. He came to Cancun averaging 22.5 points a game.
"He's our captain, our leader and our best player," Dawkins said.
Other than Fields, who hit nine of 16 shots, Stanford struggled for points. The other Cardinal players made 12 of 38 shots.
Stanford's goal to play good defense was met in the victory over Virginia, which made just 37.8 percent of its shots (4-for-18 from three-point range).
"Something we've concentrated on for a few weeks: Just our overall help defense and rotating," Dawkins said.
As for facing Kentucky, Dawkins said he would get his first look at tape of UK later in the evening.
"I know they have terrific talent and a terrific coach," Dawkins said. "So I know they'll be a formidable team."
A former star player and later assistant coach for Duke, Dawkins acknowledged the elite position of Kentucky.
"If we can raise Stanford's level to the program we're going to face tomorrow and to the level of a program like Duke, I think we'd be pretty proud."
Familiar face
Former UK walk-on Dwight Perry is a volunteer student helper for Stanford. He's completing work on his degree at nearby San Jose State.
Asked about Perry's duties, Dawkins said, "Anything from doing laundry to keeping stats ... But nothing on the court."


text: Is it valid to say (in the mouseUp script) ..... of grp me into .... Isn't 'me' a button, so "grp me" is unclear ? [ or did you mean to say put the short name of grp tGroup into ... ? ] -- Alex. On 14/08/2015 23:50, William Prothero wrote: > Folks: > I just encountered what appears to be an error in the group function. > > To duplicate, make a new stack. > Make a graphic for a background > Make a button > group the graphic and the background > Name the group something, anything, like "myGroup" > inside the button script, put: > > on mouseUp > send "getGroup" to grp "myGroup" > put the long name of me into lName > put wordOffset("Group",lName) into nw > put word nw+1 of lName into tGroup > breakpoint > put the short name of grp me into tGroup > answer tGroup > end mouseUp > > in the group script, put: > on getGroup > put the short name of grp me into theGroupName > breakpoint > end getGroup > > You will notice that the "put the short name of grp me …." statement, the correct group name is in tGroup. However, if you continue past the breakpoint, the code fails. You can verify that the statement "put the short name of grp me into tGroup" works by putting a breakpoint in the group script. > > It's not a show-stopper, but seems to be a bug. > > Verify, anybody? > > Best, > Bill > > William A. Prothero > http://es.earthednet.org/ > > _______________________________________________ > use-livecode mailing list > use-livecode at lists.runrev.com > Please visit this url to subscribe, unsubscribe and manage your subscription preferences: > http://lists.runrev.com/mailman/listinfo/use-livecode


text:
Maybe you exercise to tone your thighs, build your biceps, or flatten your belly. Or maybe you work out to ward off the big killers like heart disease, diabetes, and cancer. But how about sweating to improve your mind? "Exercise is the single best thing you can do for your brain in terms of mood, memory, and learning," says Harvard Medical School psychiatrist John Ratey, author of the book, Spark: The Revolutionary New Science of Exercise and the Brain. "Even 10 minutes of activity changes your brain." If you need a little extra incentive to lace up those sneakers, here are five ways that exercise can boost your brainpower.
HOW TO DO IT: Start with your weight on your right leg with your knee bent. Bent your left knee so your foot is slightly off the ground. Push off your right leg and jump to your left, landing softly and holding that position for a one-count, keeping your hips back and down throughout. Reverse the movement and repeat, gradually increasing your speed and range of motion.
"You'll definitely feel a minute of boat with the belly drawn in and the chest lifted," says West. It's tough to hold this for the full 60 seconds, but there's no better way to end a workout than with a challenge, right? (That being said, if you are struggling to maintain proper form for the full minute, take a break after 30 seconds, reset, and try holding for another 30.)
Want to see those arms getting leaner in a hurry? Try adding some dips to your routine. While there are resistance machines that can help you tackle this exercise, it's also easily accomplished using parallel bars or even a sturdy chair at home. With your arms shoulder-width apart by your waist, grip whatever surface you're dipping on. Bend your elbows at a 90-degree angle, bringing your whole body down, and extend to straighten your arms again. Not only does this help build strong triceps, it can also help you define your pectoral muscles, making your whole upper body look and feel stronger.
Think you can't get a good workout while you're sitting? Think again. In fact, the seated lat pulldown is one of the best exercises for toning those arms in a hurry. Using a pulldown machine, grip the bar and pull to chest level, and then raise again. This exercise makes it easy to build your biceps quickly and helps strengthen and tone your shoulders, which can make your arms look leaner, as well.
Because exercise helps use up oxygen, it causes your body to burn stored fat and helps you maintain a normal weight. For instance, if you walk 4 miles a day four times a week, you can burn about 1,600 calories or nearly half a pound a week. If you don't change your diet at all and keep walking the same distance over six months, you'll lose 12 pounds. Walk the same distance for a year and you'll drop 24 pounds.
Copyright © 2019 Leaf Group Ltd. Use of this web site constitutes acceptance of the LIVESTRONG.COM Terms of Use, Privacy Policy and Copyright Policy. The material appearing on LIVESTRONG.COM is for educational use only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse any of the products or services that are advertised on the web site. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the advertisements are served by third party advertising companies.
Exercise improves self-confidence. One of the reasons many individuals do not attempt an exercise program is because they feel they are not very athletic or coordinated. Once an exercise program is begun, however, these same individuals discover that they are indeed able to work out successfully: gaining muscle tone and strength, improving their stamina, and improving how they feel emotionally. These revelations are very empowering. It is this increased sense of self confidence and improved sense of well-being that eventually becomes the sustaining force that helps people to continue their exercise program.
If you're irritated by sagging upper arms, you're not alone! As universal as complaints about thigh fat and belly bulge are, the same can be said for complaints about arm fat. If you've dealt with excess arm fat before, you know how frustrating it can be to try on so many dresses and tops that are otherwise perfect, except that they don't have sleeves and you just want to hide your arms! And you are acutely aware of how embarrassing it is that you don't want to clap in public or wave your arms due to that all-too-familiar jiggle effect. So it's time to free yourself from saggy, waving upper arms and tone those babies up. Here's our comprehensive guide on how to lose arm fat. There's no magic trick, but if you do this right, you can lose the higgle and uncover strong, toned arms.
Starting your day with a workout could be the key to getting rid of those jiggly upper arms at record speed. Researchers at Northumbria University found that, among a group of physically active male study subjects, those who hit the gym before eating breakfast burned nearly 20 percent more fat than those who fueled up before exercising. So, if you're eager to shed that fat fast, a fasting workout can help you achieve those goals right on schedule. When you're back home post-workout, nourish your muscles with the best breakfast foods for weight loss and you'll keep your metabolism going strong all day.
There are few experiences in life more pleasurable than turning up the music and drowning out the world around you. With so many podcasts and music apps available on your smartphone, you can easily find entertainment options perfectly suited to your personal tastes. Never worry what people may think of you when working out;instead, crank up the volume and get lost in your own world. You'll be in shape before you know it.
Are you constantly misplacing your keys or struggling to recall names? Exercising regularly can help jog your memory. A 2014 study found that aerobic exercise, like running or swimming, boosts the size of the hippocampus, the part of the brain responsible for memory and learning, in women with a recognized risk factor for dementia. (9) Besides looking to brain food to boost your memory and mental skills, start breaking a sweat!
This is a particularly cool one. Neuroscientists used to believe the brain was the only organ incapable of growing new cells—which partly makes sense, since we need our brains to be relatively stable over time, to keep our memories intact and to keep us us. But in recent years, it's become clear that the brain, too, can grow new neurons, in a process called neurogenesis. And what seems to spur the growth of new neurons, perhaps above other activities, is aerobic exercise. (Other things, like meditation and antidepressant medication, have also been shown to trigger brain new cell growth.) The area of the brain that seems most capable of growing new cells is the hippocampus, the seat of learning and memory. It's also the area that's known to "shrink" in depression, and particularly in dementia—so the fact that we may have some control over its health is exciting.
You've cut your cancer risk. In a study of more than 14,800 women, those who had the highest levels of aerobic fitness were 55 percent less likely to die from breast cancer than those who were sedentary. Women considered moderately fit had about a 33 percent lower risk of developing the disease. Exercise may also help protect against endometrial, lung, and ovarian cancer, researchers say.
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Stand with your feet placed shoulder width apart and arms extend straight to your sides, raised at shoulder height. Now, do 50 small circles with your hands by rotating them in the forward direction. Then switch to 50 small backward circles. The backward and forward arm movement tones all the muscles of the arms including the triceps, biceps, shoulders and back muscles as well.
The answer, then, is a short workout, right? Something that takes, say, 20 minutes tops. You'll usually be able to squeeze that in between punching out at work and getting ready for your evening activities. But here's the rub: It may only take you 20 minutes to train, but it takes 10-15 minutes (at least) to drive to the gym, five minutes or so to get in and out of the locker room, then 10-15 minutes to drive back home. You're talking at least 45 minutes for the whole deal, but probably more like an hour-plus.
Check out our Nutrition Calculator, where you can plug in all your information and it'll spit out the right number of calories and macronutrients you should be consuming to hit your goals. If you need help using the calculator, take a look at our video tutorial that shows you how to enter all of your information to get the right metrics. If you get that nutrition on point for an extended period of time, you will lose body fat in general which will lead to you losing the fat on your arms.
Science is also showing that even short bursts of exercise can have a significant impact on your brain function in the short term. A study published in January 2018 in the journal Neuropsychologia found that when participants cycled for 10 minutes (either moderately or vigorously) on a stationary bike, their measured reaction times to a cognitively demanding task were significantly more accurate and faster than when they did the task after not doing any physical activity, meaning their attention was sharper.
HOW TO DO IT: Assume a bent-knee push-up position with your hands underneath your shoulders and your knees bent at 90-degrees, feet underneath hips. Step your left hand and your right foot forward and continue to crawl forward so that your opposite hand and foot are moving together. Repeat for 30 to 60 seconds. Start with smaller, slower steps and gradually increase the speed and distance traveled per step over time.
Whether it's a pick-up game of soccer, a group class at the gym, or just a run with a friend, exercise rarely happens in a bubble. And that's good news for all of us. Studies show that most people perform better on aerobic tests when paired up with a workout buddy Aerobic exercise is promoted when individual performance affects the group: a test of the Kohler motivation gain effect. Irwin, B.C., Scorniaenchi, J., Kerr, N.L. et al. Kinesiology, Michigan State University, East Lansing, MI. Annals of Behavioral Medicine 2012;44(2):151-9.. Pin it to inspiration or good old-fashioned competition, nobody wants to let the other person down. In fact, being part of a team is so powerful that it can actually raise athletes' tolerances for pain Rowers' high: behavioural synchrony is correlated with elevated pain thresholds. Cohen EE, Ejsmond-Frey R, Knight N, Dunbar RI. Institute of Cognitive and Evolutionary Anthropology, University of Oxford, Oxford, UK. Biology Letters 2010 February 23;6(1):106-8.. Even fitness beginners can inspire each other to push harder during a sweat session, so find a workout buddy and get moving! Two-playered partner exergame for obesity prevention: using discrepancy in players' abilities as a strategy to motivate physical activity. Feltz, D.L., Irwin, B., Kerr, N. Department of Kinesiology, Michigan State University, East Lansing, MI. Journal of Diabetes Science and Technology 2012; 6(4):820-7.
While a Bulgarian split squat isn't technically a zero-equipment move, they can still be done pretty much anytime, anywhere. "It activates many muscle groups and can be performed with any lifted surface, like a couch, bench, small table, or even an airport chair," says DiDomenico. The move is a major lower-body burner—you'll feel it in your quads, glutes, inner thighs, hamstrings, and even your calves.
Femina has been capturing the essence of the Indian woman for 58 years now, and has evolved with her over the years bringing the world to her doorstep. And now, here's your chance to get the dope on everything--from celebrities and fashion, beauty and wellness, to lifestyle and relationships--delivered directly to your inbox. Plus expert tips, polls, contests and other interactive articles and a whole lot more!
Because exercise helps use up oxygen, it causes your body to burn stored fat and helps you maintain a normal weight. For instance, if you walk 4 miles a day four times a week, you can burn about 1,600 calories or nearly half a pound a week. If you don't change your diet at all and keep walking the same distance over six months, you'll lose 12 pounds. Walk the same distance for a year and you'll drop 24 pounds.
When it comes to these pushups, make sure your left and right hands are shoulder-width apart to keep proper form. Keep your left elbow and right elbow in as well so you can activate not only your triceps but also your chest. This exercise is great because it helps you protect your rotator cuff, which is upon your shoulders. Shoot for 15 to 20 reps in this 30-second set. Don't go for high speed, go for perfect form.
"Telomeres are a good index of cellular aging," says study author Larry Tucker of Brigham Young University. "In short, because of lifestyle differences, some adults are older biologically than their chronological age, while others are younger. Given the same chronological age, adults who engage in high levels of physical activity have nine years' less cell aging than sedentary individuals. That is substantial and meaningful."
Begin with a free weight in your right hand. Rest your left hand and bent left leg on the exercise bench. Your left hand should be directly under your left shoulder so it supports your body. Bend your right hand while holding the free weight, making sure your back is straight and your torso is almost parallel to the floor. Form a 90-degree angle between your forearm and your upper arm. Keep your head up and your neck straight.
I wanted to eat Tortilla chips with nacho cheese dips for the second time in my life (in fact its probably the first time because its been so long that i dont even remember if that was even a cheese that i used as dips). You convinced me not to eat it. just ran for like 20 minutes ad burned about 250 to 300 calories about two hours earlier too. kind of feeling bad for not eating the cheese.
Exercise reduces risks for serious illness. Exercise reduces people's chances of developing and dying of illnesses such as heart disease. It does this by lowering illness risk factors such as triglyceride and overall cholesterol levels, while improving the level of HDL (the "good" cholesterol which is thought to reduce the risk of heart disease). Weight-bearing exercise and strength training activities help to maintain or increase bone mass, reducing a person's risk for osteoarthritis and associated bone fractures. Regular exercise also lowers resting blood pressure rates for hours after an exercise session is over. In addition, moderate exercise may significantly reduce the risk of developing type II diabetes. Arthritics who exercise often experience more strength and flexibility in their affected joints as well as a reduced pain levels. Furthermore, exercise may delay or prevent the development of arthritis in other joints. Regular walking of over a mile a day has been shown to reduce the risk of stroke significantly. Exercise even appears to reduce the risk of developing some cancers, especially cancers of the breast and colon.
Starting your day with a workout could be the key to getting rid of those jiggly upper arms at record speed. Researchers at Northumbria University found that, among a group of physically active male study subjects, those who hit the gym before eating breakfast burned nearly 20 percent more fat than those who fueled up before exercising. So, if you're eager to shed that fat fast, a fasting workout can help you achieve those goals right on schedule. When you're back home post-workout, nourish your muscles with the best breakfast foods for weight loss and you'll keep your metabolism going strong all day.


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My Recent Publications
Hsp90 regulation of fibroblast activation in pulmonary fibrosis.
Hsp90 regulation of fibroblast activation in pulmonary fibrosis.
JCI Insight. 2017 Feb 23;2(4):e91454
Authors: Sontake V, Wang Y, Kasam RK, Sinner D, Reddy GB, Naren AP, McCormack FX, White ES, Jegga AG, Madala SK
Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease associated with fibroblast activation that includes excessive proliferation, tissue invasiveness, myofibroblast transformation, and extracellular matrix (ECM) production. To identify inhibitors that can attenuate fibroblast activation, we queried IPF gene signatures against a library of small-molecule-induced gene-expression profiles and identified Hsp90 inhibitors as potential therapeutic agents that can suppress fibroblast activation in IPF. Although Hsp90 is a molecular chaperone that regulates multiple processes involved in fibroblast activation, it has not been previously proposed as a molecular target in IPF. Here, we found elevated Hsp90 staining in lung biopsies of patients with IPF. Notably, fibroblasts isolated from fibrotic lesions showed heightened Hsp90 ATPase activity compared with normal fibroblasts. 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), a small-molecule inhibitor of Hsp90 ATPase activity, attenuated fibroblast activation and also TGF-β-driven effects on fibroblast to myofibroblast transformation. The loss of the Hsp90AB, but not the Hsp90AA isoform, resulted in reduced fibroblast proliferation, myofibroblast transformation, and ECM production. Finally, in vivo therapy with 17-AAG attenuated progression of established and ongoing fibrosis in a mouse model of pulmonary fibrosis, suggesting that targeting Hsp90 represents an effective strategy for the treatment of fibrotic lung disease.
PMID: 28239659 [PubMed - in process]
Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.
Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.
PLoS One. 2017;12(1):e0170446
Authors: Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana Hershey GK, Medvedovic M, Dillon SR, Madala SK
[This corrects the article DOI: 10.1371/journal.pone.0161877.].
PMID: 28114322 [PubMed - in process]
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.
J Mol Cell Cardiol. 2016 Dec 09;:
Authors: Lynch TL, Ismahil MA, Jegga AG, Zilliox MJ, Troidl C, Prabhu SD, Sadayappan S
Cardiomyopathies are a leading cause of heart failure and are often caused by mutations in sarcomeric genes, resulting in contractile dysfunction and cellular damage. This may stimulate the production of a robust proinflammatory response. To determine whether myocardial inflammation is associated with cardiac dysfunction in dilated cardiomyopathy (DCM) caused by MYBPC3 mutation, we used the well-characterized cMyBP-C((t/t)) mouse model of DCM at 3months of age. Compared to wild type (WT) mice, DCM mice exhibited significantly decreased fractional shortening (36.4±2% vs. 15.5±1.0%, p<0.0001) and significantly increased spleen weight (5.3±0.3% vs. 7.2±0.4mm/mg, p=0.002). Intriguingly, flow cytometry analysis revealed a significant increase in total (CD45(+)CD11b(+)Ly6C(-)MHCII(+)F480(+)) macrophages (6.5±1.4% vs. 14.8±1.4%, p=0.002) and classically activated (CD45(+)CD11b(+)Ly6C(-)MHCII(+)F480(+)CD206(-)) proinflammatory (M1) macrophages (3.4±0.8% vs. 10.3±1.2%, p=0.0009) in DCM hearts as compared with WT hearts. These results were further confirmed by immunofluorescence analysis of heart tissue sections. Splenic red pulp (CD11b(+)Ly6C(+)MHCII(low)F480(hi)) macrophages were significantly elevated (2.4±0.1% vs. 1.3±0.1%, p=0.0001) in DCM compared to WT animals. Serum cytokine analysis in DCM animals exhibited a significant increase (0.65±0.2 vs. 2.175±0.5pg/mL, p=0.02) in interleukin (IL)-6 compared to WT animals. Furthermore, RNA-seq analysis revealed the upregulation of inflammatory pathways in the DCM hearts. Together, these data indicate a robust proinflammatory response in DCM hearts, likely in response to cellular damage triggered by MYBPC3 mutation and resultant contractile dysfunction.
PMID: 27955979 [PubMed - as supplied by publisher]
Pharmacogenomics and chemical library screens reveal a novel SCF(SKP2) inhibitor that overcomes bortezomib resistance in multiple myeloma.
Pharmacogenomics and chemical library screens reveal a novel SCF(SKP2) inhibitor that overcomes bortezomib resistance in multiple myeloma.
Leukemia. 2016 Sep 28;
Authors: Malek E, Abdel-Malek MA, Jagannathan S, Vad N, Karns R, Jegga AG, Broyl A, van Duin M, Sonneveld P, Cottini F, Anderson KC, Driscoll JJ
While clinical benefit of the proteasome inhibitor (PI) bortezomib for multiple myeloma (MM) patients remains unchallenged, dose-limiting toxicities and drug resistance limit the long-term utility. The E3 ubiquitin (Ub) ligase Skp1-Cullin-1-Skp2 (SCF(Skp2)) promotes proteasomal degradation of the cell cycle inhibitor p27 to enhance tumor growth. Increased SKP2 expression and reduced p27 levels are frequent in human cancers and are associated with therapeutic resistance. SCF(Skp2) activity is increased by the Cullin-1-binding protein Commd1 and the Skp2-binding protein Cks1B. Here, we observed higher CUL1, COMMD1 and SKP2 mRNA levels in CD138(+) cells isolated from bortezomib-resistant MM patients. Higher CUL1, COMMD1, SKP2 and CKS1B mRNA levels in patient CD138(+) cells correlated with decreased progression-free and overall survival. Genetic knockdown of CUL1, COMMD1 or SKP2 disrupted the SCF(Skp2) complex, stabilized p27 and increased the number of annexin-V positive cells after bortezomib treatment. Chemical library screens identified a novel compound, designated DT204, that reduced Skp2 binding to Cullin-1 and Commd1, and synergistically enhanced bortezomib-induced apoptosis. DT204 co-treatment with bortezomib overcame drug resistance and reduced the in vivo growth of myeloma tumors in murine models with survival benefit. Taken together, the results provide proof-of-concept for rationally-designed drug combinations that incorporate SCF(Skp2) inhibitors to treat bortezomib resistant disease.Leukemia accepted article preview online, 28 September 2016. doi:10.1038/leu.2016.258.
PMID: 27677741 [PubMed - as supplied by publisher]
IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.
IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.
PLoS One. 2016;11(8):e0161877
Authors: Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana GH, Medvedovic M, Dillon SR, Madala SK
Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple chronic diseases of the skin and lungs. IL-31 is upregulated in allergic and inflammatory diseases, including atopic dermatitis, asthma, cutaneous T-cell lymphomas, and allergic rhinitis, as well as autoimmune diseases such as systemic erythematosus. Overexpression of IL-31 in T cells causes severe inflammation, with histological features similar to skin lesions of patients with atopic dermatitis. However, the molecular mechanisms involved in IL31-driven pathological remodeling in skin diseases remain largely unknown. Here, we studied the role of IL-31 in skin damage as a result of intradermal administration of recombinant IL-31 into mice. Notably, IL-31 was sufficient to increase epidermal basal-cell proliferation and thickening of the epidermal skin layer. Our findings demonstrate a progressive increase in transepidermal water loss with chronic administration of IL-31 into the skin. Further, analysis of the skin transcriptome indicates a significant increase in the transcripts involved in epidermal-cell proliferation, epidermal thickening, and mechanical integrity. In summary, our findings demonstrate an important role for IL-31 signaling in epidermal cell proliferation and thickening that together may lead to impaired skin-barrier function in pathological remodeling of the skin.
PMID: 27556734 [PubMed - as supplied by publisher]
Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data.
Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data.
Nat Biotechnol. 2016 Jul 12;34(7):697-700
Authors: Sarangdhar M, Tabar S, Schmidt C, Kushwaha A, Shah K, Dahlquist JE, Jegga AG, Aronow BJ
PMID: 27404875 [PubMed - as supplied by publisher]
Canonical genetic signatures of the adult human brain.
Canonical genetic signatures of the adult human brain.
Nat Neurosci. 2015 Dec;18(12):1832-44
Authors: Hawrylycz M, Miller JA, Menon V, Feng D, Dolbeare T, Guillozet-Bongaarts AL, Jegga AG, Aronow BJ, Lee CK, Bernard A, Glasser MF, Dierker DL, Menche J, Szafer A, Collman F, Grange P, Berman KA, Mihalas S, Yao Z, Stewart L, Barabási AL, Schulkin J, Phillips J, Ng L, Dang C, Haynor DR, Jones A, Van Essen DC, Koch C, Lein E
The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing mesoscale genetic organization. The genes with the highest differential stability are highly biologically relevant, with enrichment for brain-related annotations, disease associations, drug targets and literature citations. Using genes with high differential stability, we identified 32 anatomically diverse and reproducible gene expression signatures, which represent distinct cell types, intracellular components and/or associations with neurodevelopmental and neurodegenerative disorders. Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely patterned genes displayed marked shifts in regulation between species. Finally, highly consistent transcriptional architecture in neocortex is correlated with resting state functional connectivity, suggesting a link between conserved gene expression and functionally relevant circuitry.
PMID: 26571460 [PubMed - indexed for MEDLINE]
IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.
IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival.
Oncotarget. 2015 Dec 22;6(41):43395-407
Authors: Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI
The chromatin-binding DEK protein was recently reported to promote the growth of HPV+ and HPV- head and neck squamous cell carcinomas (HNSCCs). Relevant cellular and molecular mechanism(s) controlled by DEK in HNSCC remain poorly understood. While DEK is known to regulate specific transcriptional targets, global DEK-dependent gene networks in HNSCC are unknown. To identify DEK transcriptional signatures we performed RNA-Sequencing (RNA-Seq) in HNSCC cell lines that were either proficient or deficient for DEK. Bioinformatic analyses and subsequent validation revealed that IRAK1, a regulator of inflammatory signaling, and IRAK1-dependent regulatory networks were significantly repressed upon DEK knockdown in HNSCC. According to TCGA data, 14% of HNSCC specimens overexpressed IRAK1, thus supporting possible oncogenic functions. Furthermore, genetic or pharmacologic inhibition of IRAK1 in HNSCC cell lines was sufficient to attenuate downstream signaling such as ERK1/2 and to induce HNSCC cell death by apoptosis. Finally, targeting DEK and IRAK1 simultaneously enhanced cell death as compared to targeting either alone. Our findings reveal that IRAK1 promotes cell survival and is an attractive therapeutic target in HNSCC cells. Thus, we propose a model wherein IRAK1 stimulates tumor signaling and phenotypes both independently and in conjunction with DEK.
PMID: 26527316 [PubMed - in process]
Concept Modeling-based Drug Repositioning.
Concept Modeling-based Drug Repositioning.
AMIA Jt Summits Transl Sci Proc. 2015;2015:222-6
Authors: Patchala J, Jegga AG
Our hypothesis is that drugs and diseases sharing similar biomedical and genomic concepts are likely to be related, and thus repositioning opportunities can be identified by ranking drugs based on the incidence of shared similar concepts with diseases and vice versa. To test this, we constructed a probabilistic topic model based on the Unified Medical Language System (UMLS) concepts that appear in the disease and drug related abstracts in MEDLINE. The resulting probabilistic topic associations were used to measure the similarity between disease and drugs. The success of the proposed model is evaluated using a set of repositioned drugs, and comparing a drug's ranking based on its similarity to the original and new indication. We then applied the model to rare disorders and compared them to all approved drugs to facilitate "systematically serendipitous" discovery of relationships between rare diseases and existing drugs, some of which could be potential repositioning candidates.
PMID: 26306277 [PubMed]
Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.
Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.
Hepatology. 2016 Feb;63(2):512-23
Authors: Miethke AG, Zhang W, Simmons J, Taylor AE, Shi T, Shanmukhappa SK, Karns R, White S, Jegga AG, Lages CS, Nkinin S, Keller BT, Setchell KD
UNLABELLED: Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low-phospholipid "toxic" bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal, apical sodium-dependent bile acid transporter (ASBT), blocks progression of sclerosing cholangitis in mdr2(-/-) mice. Thirty-day-old, female mdr2(-/-) mice were fed high-fat chow containing 0.006% SC-435, a minimally absorbed, potent inhibitor of ASBT, providing, on average, 11 mg/kg/day of compound. Bile acids (BAs) and phospholipids were measured by mass spectrometry. Compared with untreated mdr2(-/-) mice, SC-435 treatment for 14 days increased fecal BA excretion by 8-fold, lowered total BA concentration in liver by 65%, reduced total BA and individual hydrophobic BA concentrations in serum by >98%, and decreased plasma alanine aminotransferase, total bilirubin, and serum alkaline phosphatase levels by 86%, 93%, and 55%, respectively. Liver histology of sclerosing cholangitis improved, and extent of fibrosis decreased concomitant with reduction of hepatic profibrogenic gene expression. Biliary BA concentrations significantly decreased and phospholipids remained low and unchanged with treatment. The phosphatidylcholine (PC)/BA ratio in treated mice corrected toward a ratio of 0.28 found in wild-type mice, indicating decreased bile toxicity. Hepatic RNA sequencing studies revealed up-regulation of putative anti-inflammatory and antifibrogenic genes, including Ppara and Igf1, and down-regulation of several proinflammatory genes, including Ccl2 and Lcn2, implicated in leukocyte recruitment. Flow cytometric analysis revealed significant reduction of frequencies of hepatic CD11b(+) F4/80(+) Kupffer cells and CD11b(+) Gr1(+) neutrophils, accompanied by expansion of anti-inflammatory Ly6C(-) monocytes in treated mdr2(-/-) mice.
CONCLUSION: Inhibition of ASBT reduces BA pool size and retention of hydrophobic BA, favorably alters the biliary PC/BA ratio, profoundly changes the hepatic transcriptome, attenuates recruitment of leukocytes, and abrogates progression of murine sclerosing cholangitis.
PMID: 26172874 [PubMed - in process]
Polycomb repressive complex 1 controls uterine decidualization.
Polycomb repressive complex 1 controls uterine decidualization.
Sci Rep. 2016;6:26061
Authors: Bian F, Gao F, Kartashov AV, Jegga AG, Barski A, Das SK
Uterine stromal cell decidualization is an essential part of the reproductive process. Decidual tissue development requires a highly regulated control of the extracellular tissue remodeling; however the mechanism of this regulation remains unknown. Through systematic expression studies, we detected that Cbx4/2, Rybp, and Ring1B [components of polycomb repressive complex 1 (PRC1)] are predominantly utilized in antimesometrial decidualization with polyploidy. Immunofluorescence analyses revealed that PRC1 members are co-localized with its functional histone modifier H2AK119ub1 (mono ubiquitination of histone-H2A at lysine-119) in polyploid cell. A potent small-molecule inhibitor of Ring1A/B E3-ubiquitin ligase or siRNA-mediated suppression of Cbx4 caused inhibition of H2AK119ub1, in conjunction with perturbation of decidualization and polyploidy development, suggesting a role for Cbx4/Ring1B-containing PRC1 in these processes. Analyses of genetic signatures by RNA-seq studies showed that the inhibition of PRC1 function affects 238 genes (154 up and 84 down) during decidualization. Functional enrichment analyses identified that about 38% genes primarily involved in extracellular processes are specifically targeted by PRC1. Furthermore, ~15% of upregulated genes exhibited a significant overlap with the upregulated Bmp2 null-induced genes in mice. Overall, Cbx4/Ring1B-containing PRC1 controls decidualization via regulation of extracellular gene remodeling functions and sheds new insights into underlying molecular mechanism(s) through transcriptional repression regulation.
PMID: 27181215 [PubMed - in process]


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The Bovril equivalent, Bovrite,
Can be purchased alongside of Marmite.
The marketer's local,
An American yokel–
I just hope that they have the extract right.
Anthropology, linguistics, archaeology, and writing systems
Wandering through the world of words and language
Carmina et Verba pro Discipulis Meis
You need the world, and the world needs good people.
Teacher, Author, Christian, Wife, Foster Mother, and Youth Sponsor...not necessarily in that order
Creating an enviroment for sexual purity, starting with the heart
Reading, writing and a-rhythmic tics
creativity : art : philosophy : productivity : writing
Discover Magically Whimsical Art Jewelry Creations


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Some glorious Transnational Dub here introduced to me by my good friend Anna Kucharska!
Greg Hunter has a long and colourful history in sound engineering, production and composition. Some of his best known credits include work with Orb and Youth. But it is his catalogue of works as a producer and musician that have enthralled his fanbase for years. From creation of the seminal world dub of 1994 Subsurfing album, to the classics of Lotus Blossom, Sout el Leil and Fifth Sun; Greg has proven himself to be a pioneer of contemporary electronica. Always sailing close to the edge of the limits of perceived sound, crafting his ethnodelic music by working with classical and Indigenous musicians around the world, and creating a seamless blend of modern technology with ancient musical traditions.
Check out loads more HERE
"With the passage of an immense length of time, conditions begin to change. A scum, with the character of boiled, milky rice, begins to accumulate on the cooling earth, and the terrestrial inhabitants begin to taste it and enjoy the sensation. This new sense pleasure leads to craving and an ever-increasing dependence on the scum for nourishment. The earthly residents find that their formerly light, ethereal bodies become gross and solid and more differentiated in shape and appearance. Gradually, the waters covering the earth subside; the mists disperse and the sun and moon are clearly revealed in the heavens."
When even our self does not belong to us, what else in the world can we call our own?
All that we collect and gather in the external world for our happiness and comfort is limited. Not even a thousandth part of this world that we possess can we really call our own kingdom, our world. But our mind can create and can collect numberless thoughts and impressions, which all make up its real world. All our possessions, all that we collect in life, all these things which we shall have to leave one day are transitory; but that which we have created in our thought, in our mind, that lives.
IN AN EASTERN ROSE GARDEN – Mental Creation
The pairing of the six traditional enemies creates the three mystical animals;
garuda and snow-lion
otter and fish
crocodile and sea-snail.
These animal symbols of universal love represents the spreading of harmony, as they depict combinations of mutually hostile animals.
Khaleeji Dub (first build) by dubsahara
First build of a track i wrote in cairo during the revolution in spring 2011.
it was late at night in a studio in Giza.
everyone had left because of the curfew,
so it was only me and a couple of the night guys left.
and then that bass line dropped like a crystal of joy.
this is the first build,, very raw..


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Rede anlässlich der Entgegennahme der Auszeichnung der Europäischen Lungenstiftung 2014 im Namen der WHO für ihre Leitlinien zur Qualität der Außenluft
6 September 2014, Munich, Germany
Dear Ms Fletcher, Professor Barnes,
Ladies and gentlemen,
It is a great pleasure and honour to accept the 2014 Annual European Lung Foundation Award on behalf of the World Health Organization (WHO) for our efforts in improving the health and well-being of people by addressing the key determinants of respiratory health.
There is no doubt that healthy lungs are essential for quality of life. Yet respiratory diseases still remain a leading cause of death and disability in Europe and across the world.
Prevention and control of respiratory diseases are important elements of the WHO European health policy framework, Health 2020, and the Action Plan for Implementation of the European Strategy for the Prevention and Control of Noncommunicable Diseases 2012−2016, including the measures to strengthen the response to chronic diseases, combat indoor and outdoor air pollution, and efforts to implement effectively the WHO Framework Convention on Tobacco Control.
In the field of communicable diseases, our focus on respiratory diseases has been on the prevention and control of infectious diseases including influenza, tuberculosis and multidrug-resistant tuberculosis. In 2011, the WHO Regional Committee for Europe unanimously adopted the Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-resistant Tuberculosis in the WHO European Region 2011–2015, which was developed through a consultative and iterative process with our Member States and partners like the European Respiratory Society and civil society. We are now in the process of developing, through a similar consultative process, the regional tuberculosis action plan 2016–2020, to implement the global strategy and targets for TB prevention, care and control after 2015. I have appointed a Special Representative of the Regional Director to Prevent and Combat multidrug and extensively drug-resistant TB in the WHO European Region as a sign of my personal commitment to lung health, and the fight against MDR-TB and respiratory diseases. We have been working very closely with our 53 Member States in the WHO European Region and key partners, particularly the European Respiratory Society, to monitor the health indicators, build scientific evidence for intervention, and facilitate country capacity building to address the health inequalities through health systems' lens and people-centred approaches. However, as you are aware, a great deal more is needed to achieve better protection of lung health in Europe.
Let me speak about one of the most important public health challenges. At least six hundred thousand people die as a consequence of indoor and outdoor air pollution in the WHO European Region every year. Seven million people die from the same cause globally.
Science provides convincing arguments for decisive action to improve air quality and reduce related deaths and diseases in Europe.
The leading sources of harmful pollution – transport, burning of coal in power plants and households, burning of biomass and industry – cause over 80% of the population of the European Union to live in cities with particulate matter levels exceeding the WHO air quality guidelines. This pollution creates a substantial burden of disease, reducing life expectancy by almost 9 months on average.
An evidence review conducted by the WHO Regional Office for Europe last year indicated that health effects occur at air pollution concentrations even lower than the existing guideline levels. Results from recent scientific projects indicate that average life expectancy in the most polluted cities could be increased by approximately 20 months if the long-term particulate matter concentration was reduced to the WHO annual guideline level. In line with those findings, the WHO Regional Office for Europe has initiated the revision of the air quality guidelines, which should be completed in the coming two years.
There is also consistent evidence that lower air pollution levels resulting from sustained, long-term interventions result in health benefits for the population, with improvements in population health occurring within a few years after the reduction in pollution. Decreased levels of particulate air pollution can substantially diminish total, respiratory and cardiovascular death rates. Benefits can be expected at almost any reduction in levels of air pollution, suggesting that any good policy intervention is likely to have continuing favourable effects on public health.
Interventions and policies that improve air quality often have significant co-benefits in addressing other important and urgent public health concerns of our times. Cleaner energy production often reduces greenhouse gas emissions as well, mitigating climate change. Improved transport policies and systems not only reduce air pollution but also stimulate active transportation and physical activity and, therefore, contribute to addressing obesity.
It is a fundamental public health responsibility of governments to ensure safe living conditions for all people. Issues like air quality are a perfect example of why health is the business of the whole government. While the health sector should be able to observe, measure and understand common threats to people's health and guide the design and implementation of effective standards and policies, it is the other sectors, such as transport, energy, agriculture, urban and land management that have to act appropriately.
In the WHO European Region, this was understood a long time ago. The European environment and health process, initiated in 1989, developed into a perfect example of intersectoral governance at the international level. It addresses environmental health determinants from a wide perspective of societal priorities of improving health, preserving the environment, developing sustainable societies and economies while promoting environmental and societal justice. In that context, the WHO Regional Office for Europe exercises its core functions of normative guidance and public health policy leadership on the leading health issues of our times.
The WHO air quality guidelines led to the adoption of national air quality standards and of the clean-air directive in the European Union. They are also the basis for the implementation of the Convention on Long-range Transboundary Air Pollution. Together with the current revision of those guidelines in the context of the new evidence, this is a prime example of our role in international public health, of which we are very proud. I therefore thank you wholeheartedly for the recognition of our role in international public health and of our contribution to the better health and well-being of our citizens.
Thank you.


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Secure Trust plans challenger bank buyout binge
Secure Trust Bank is planning major acquisitions in a buyout plan which could make the start of a much-anticipated wave of consolidations and mergers in the challenger banking sector.
A series of new banks have been established in recent years with some success, but many bankers and analysts believe that to really shake up the market and threaten the big banks, mergers are needed.
Secure Trust Bank (STB) is older but is rapidly growing, and chief executive Paul Lynam believes the chance may be coming to lead the transformation of the industry.
STB is majority owned by Arbuthnot Banking Group, but the parent is selling down its stake in a move which will allow new institutional investors into...
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Arrow Electronics announces support services for Microsoft cloud. Arrow has designed a dedicated set of comprehensive services based on global best practices.
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Increased reliance on technology makes professional training more critical than ever. Arrow has a vast training portfolio.
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If you are not selling support services to your customers then someone else is. With Arrow, selling support has never been so easy.
Arrow is a technology company that brings innovative IT solutions to market to solve complex business challenges and develops technology solutions that improve business and daily life.
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Family Guy
S5E4: Saving Private Brian
Views: 52
- Three tracks! - Come on! - We can go all day with this! - Yeah, but... That's it! Every single track, plus the hidden bonus track! There's a hidden bonus track? Oh, I hope it's a ballad. Should I follow the knight into the dungeon, or should I go back the way I came?
Edit Clip Timeline
Also This


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We're a husband & wife wedding photography team
who specialise in timeless, beautiful photography.
Our philosophy is all about making genuine connections, creating incredible experiences
and documenting your love in a fun, relaxed way.
and documenting your love in a fun, relaxed way.
I'm passionately obsessed about documenting life with my camera and I love the true connections I get to make with the people I photograph.
I love capturing natural moments as they happen so I work hard to ensure you're relaxed & having fun in front of my camera. I will give you guidance so that you don't feel frozen or awkward, but I work to get candid photos by giving relaxed direction and styling.
And it's not just about documenting your wedding day. For me being a photographer is also about helping you plan for your photos, creating a fun relaxed atmosphere, turning your images in to quality products that will be treasured forever and exceeding your every expectation every step of the way.
Capturing your love story is not a transaction for me, it's a privilege.
"There aren't enough words to express just how much we want to thank you for the amazing engagement shots you captured of us! You captured us so naturally and beautifully. You made us feel so at ease and we just loved the afternoon we spent with you both!" - Danique & Mitch
"I could not imagine our photos to be any more perfect. I feel so lucky to have found you to be our wedding photographer." - Mary & Rory
"Heidi you special thing! Received our album today and love love love it!
Thank you soo much for everything! I'm soo glad we decided to fork out for a photographer, and in the process we've really learnt to appreciate that it is worth every cent!" - Tim & Becky
"The patience you have and the eye for capturing the special in-between moments are amazing! You managed to make us feel at ease and relaxed for our engagement portraits." - Rebecca & Korey
Get in touch
Engaged and planning your wedding?
Get in touch today - we'd love to hear from you!
Wedding Hub
Wedding advice, info, blog posts, tips & more...everything wedding related in one place!
Heidi & Matt
Established in 2007.
They've shot over 50 weddings together.
Get to know more about the Horton duo...


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This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.
Info: EG; Same primer pair as used in qPCR assay qRnoCID0002201; intron_spanning
Assay Information
Gene Information
ubiquitin-protein ligase; may regulate autoimmunity; implicated as a susceptibility gene for type I diabetes (IDDM) [RGD, Feb 2006]


text: Cats don't take guff from humans, never mind stuffed animals. We had a stuffed Bill Clinton for our cat Henry, but he soon lost interest in it. Robbie goes after stuffed bunnies, and our painted turtle went into his courtship ritual for a toy turtle–we didn't mean for that to happen. Anyhow, here are some cats who react bravely when confronted with the unknown. An inspiration to us all.


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Information Security
Security Training
Security Training – Learn how to be safer and more secure when using technology. Take the University's annual online Security Awareness Training course.
How can we help you?
- Report a possible phishing attempt
- I need to complete Security Awareness Training
- I need to reset or recertify my CNetID or password.
- I want to know how to use two-factor authentication.
- I need an SSL, code signing, or some other kind of security certificate.
- Report a possible compromise or other security incident
- I have a question about security for my application or have my application reviewed.
- My account was locked for spamming or due to some other security issue.
- I need access to phone records, emails, or other data for an investigation or personnel matter.
- I'm traveling and received an email asking that I contact the security team.
- My computer or phone was blocked from the network due to a virus detection.
- I want to send the security team a report about a security vulnerability or some other issue I discovered.
- A website I tried to visit is blocked and erroneously listed as suspicious. What do I do?
IT Policies
Refer to the University's official IT policies regarding data security and use of copyrighted material.
Training and User Guides
Complete security training and get user guides for helpful security tips and advice.
Phishing Alerts
Listed below are the latest phishing scams that have been acted upon by Information Security. Think you've received a phishing email? Don't click it, report it.
Email Scam (Oct 15, 2019): "Password Check Required Immediately"
From: "Information Technology" <firstname.lastname@example.com> <email@example.com> Sent: Tuesday, October 15, 2019 3:26 PM To: firstname.lastname@example.com Subject: Password Check Required Immediately Dear Staff, As part of ongoing efforts to maintain regulatory compliance...read more
Email Scam (Oct 13, 2019): "Hi Martha"
From: MARY LOU GORNO <firstname.lastname@example.com> Sent: Saturday, October 12, 2019 5:39:13 PM Subject: Hi Martha How are you? I'm sorry to bother you, Are you busy ? Regards. Mary Lou Gorno Chair of the Smart Museum of Art Board Of Governorsread more
Email Scam (Oct 10, 2019): "Faculty Evaluation.docx"
From: "IT HelpDesk (via Google Drive)" <firstname.lastname@example.com> Date: October 10, 2019 at 3:08:42 PM CDT Subject: Faculty Evaluation.docx email@example.com<mailto:firstname.lastname@example.com> has shared the following document:...read more
Security News
Check here for the latest security alerts that may affect you.
Statement on Data Vulnerability
An independent security researcher recently notified the University of Chicago Medical Center that a security vulnerability affected a database with information about a cross-section of individuals with connections to the University of Chicago, including some donors...
CRITICAL Security Advisory: Remote Desktop Services Remote Code Execution Vulnerability
In response to a new security vulnerability impacting users of Microsoft Windows, the University is taking actions to ensure that our campus network is protected. Starting Tuesday, May 21, the University will begin requiring all use of Remote Desktop (RDP) from...
Threatening Hoax Email
Written by Craig Drake, Information Security Engineer (ITS) IT Security has detected a new email scam that began affecting the University of Chicago community yesterday, December 13. The scam has been widely reported at other higher education institutions. The email...
Phone Calls You Can Ignore – It's a scam!
Written by Kendall R Williams, Information Security Engineer (ITS) Have you ever received a threatening phone call from the IRS, Social Security Administration, or perhaps from the Chinese Consulate? Phone scams are on the rise, especially during this time of year...
This Email Scam has a Real Password
Written by Kendall R Williams, Information Security Engineer (ITS) You may want to react to this new email scam, but don't. From: Bad Guy <email@example.com<mailto:email@example.com>> Subject: <username> - SEuJ5Kyb Lets get right to the purpose....
Vulnerability Alert: Meltdown and Spectre
What is Meltdown and Spectre? You may have heard about Meltdown and Spectre in the news these past few days. There is a lot of confusing information out there since these vulnerabilities were revealed to the public much earlier than anticipated - so we're going to...


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As arranged, the technical team will visit the blindspot (Removed due to personal information protection) 11am to 1pm on 8th after I requested several times.
Please make sure of visiting the place around 11am or before 11:30am, otherwise the IT manager may leave from the place because he is available only in the morning.
Hi Beomseok,
I have informed the team on your request. I have also removed the location of the address to safeguard your personal details. Do be advised to PM us on sensitive information instead, by clicking the words bracketed by the arrows here > via Private Message <.
Thank you.
The technician visited the place and checked the network signal strength. He said that the customer service would update me how to proceed with this issue. However, no one contacted and updated me so far.
Why nobody update me the status of this issue? And how do you fix the issue?
Actually I requested to fix the issue when the technician visited the place but he just checked the signal strength only.
Why always takes so long time to take action for the issue?
I really disappointed your lousy customer service.
Hi Beomseok, thanks for contacting us. As this requires us to refer to your account details, we are unable to assist you here on StarHub Community. Please direct your query over to Facebook messenger (http://m.me/starhub) or Twitter Direct Message (https://twitter.com/StarHubCares) so that we can log a case for you and respond to you there. Thank you!


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