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You will not be mixed with another group
We offer you a Discovery Tour consisting in: clear explanations of the vineyard, the visit of our fermenting rooms and of our elegant wine storehouse which was recently renovated. The visit will be followed by a wine tasting session of two wines from the Carles Vineyards.
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No More Business as Usual
Readers Write That United, Other Big Airlines Must Change Their Ways If They're to Survive
Many years ago, one of my predecessors on the airline beat was harangued by a CEO. "Why don't you ever write anything good about us?" he barked.
"When you run a good airline, we'll have something good to write about you," she replied.
That's how it is in this business, and not just with CEOs. Pilots, in particular, are more...

subset: commoncrawl


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text:
Baylor's Lauren Cox will not require surgery after suffering a scary knee injury late in the third quarter of Sunday's 82-81 Lady Bear victory over Notre Dame in the NCAA championship game, the school announced Monday night.
Cox suffered the injury with 1:22 left in the third quarter, and didn't return to the game. She had an evaluation, including an MRI, on Monday afternoon with Dr. Brad Gilliam of Southwest Sports Medicine and Orthopedics in Waco. Gilliam determined that Cox had suffered an MCL sprain in her left knee, with bone bruising.
Despite the fact that Cox won't need surgery, there is no timetable on her return. The recovery time for an MCL sprain varies depending on the severity of the sprain.
Cox averaged 13 points, 8.3 rebounds and a team-high 2.6 blocked shots for the national champion Lady Bears this year. The junior forward from Flower Mound, Texas, was a third-team All-American by the U.S. Basketball Writers Association and the Associated Press, and was named the Big 12's Defensive Player of the Year.


text:
While the endogenous opioid system has generally been associated with regulation of pain, it also modulates the experience of distress and may play a central role in many psychiatric and neurodevelopmental disorders. Decades of preclinical research on the analgesic effects of endogenous opioids, i.e., endorphins, suggests that opioid receptors have plastic bimodal (inhibitory/excitatory) properties that may explain conflicting findings in clinical research. An exploratory study with 60 healthy volunteer participants, using a cold pressor-induced pain paradigm, found evidence that a combination of a nutraceutical agent that enhances endorphin release (Endorphin Enhancer) with one that switches opioid receptors from an excitatory to inhibitory mode (Opioid Receptor Switcher) not only increases pain tolerance but also reduces emotional and physical distress. This discovery led to clinical application of a critically formulated endorphinergic treatment in 203 case studies over a two-year period. Findings revealed the remarkable clinical efficacy and safety of this treatment in the relief of chronic emotional and physical distress, including anxiety, anger, depression, cravings, and hyperalgesia, as well as enhancement of well-being, productivity, mental clarity, relationships, and an adaptive response to life's stresses. These studies provide new insights into the role of endogenous opioid system imbalances in the development, treatment, and prevention of dysfunctional emotional and physical distress. We postulate that an Endorphinergic Distress Syndrome (EDS) consists of abnormal endorphin levels together with opioid receptors predominately in their excitatory mode. EDS may account for many core distress symptoms associated with chronic anxiety, addictions, pain, as well as affective personality, autism spectrum, attention-deficit, and distress-related medical problems. Our research has led to new endorphinergic formulations, combining Endorphin Enhancers, such as caffeine, with Opioid Receptor Switchers, such as n-acetylcysteine, for the relief of emotional and physical distress. Our studies also provide a novel method to reverse the anxiogenic effects of caffeine and related hyperexcitatory substances.
There is significant evidence that the endogenous opioid system is involved in attenuation of the experience of pain [
Endorphins have been found to reduce the experience of emotional and physical distress including pain [4,6]. In addition, there is evidence that they have rewarding and reinforcing properties that promote hedonia and motivation, including the popular "runner's high" [7,8]. Therefore, it has been hypothesized that endorphin depletion may result from prolonged stress and trauma, leading to an increase in distress, anxiety, and depression [
The preclinical nerve tissue research of Crain and Shen [15,16] over the past three decades on the function of opioid receptors in the pain response may provide critical insights into these issues with important clinical implications [
The initial phase of this clinical investigation was designed to test the pain-relieving effects of Crain and Shen's endorphinergic cotreatment formulation, combining an Endorphin Enhancer with an Opioid Receptor Switcher, in humans, using a "cold pressor" pain assay [
For these cold pressor trials, healthy volunteer participants were recruited from the Penn State University community. Eight potential participants were eliminated from the trials since their baseline pain tolerance time was more than 2 minutes, a standard criterion used in cold pressor testing to assess meaningful experimental effects. The final 60 participants (38 males, 22 females; ages 18 - 86) went through each experimental condition, separated by at least a two-day "wash-out" period. A variety of Endorphin Enhancer and Opioid Receptor Switcher agents (and doses) were assessed in these trials, using Crain and Crain's rationale for selection of appropriate agents in each class [17,19-21]. The present report is focused on the nutraceutical agents used in these trials, all of which are considered as Generally Recognized as Safe (GRAS) by the FDA and do not require further FDA approval or a prescription. While our findings were generally consistent among all agents studied, this analysis highlights caffeine (100 mg), a PDE inhibitor that enhances endorphins by boosting cAMP levels (Endorphin Enhancer), combined with N-acetylcysteine (NAC) (600 mg), an amino acid that metabolizes into sodium sulfate thereby switching opioid receptors from an excitatory to inhibitory mode (Opioid Receptor Switcher) [
Throughout these cold pressor trials, none of the pain measures were reduced from baseline, more than placebo, by the separate administration of the Endorphin Enhancer or the Opioid Receptor Switcher. In fact, the Endorphin Enhancers, such as caffeine, produced an average 12% decrease in pain tolerance from baseline in contrast to an average 7% increase produced by the placebo. Therefore, PDE inhibitors, such as caffeine, generally triggered hyperalgesia and an increase in pain sensitivity and reactivity. However, as predicted by our bimodal theory of endogenous opioid receptor signaling, the addition of an Opioid Receptor Switcher, such as NAC, to the Endorphin Enhancer reversed this hyperalgesia and produced a dramatic average 18% increase in pain tolerance, significantly more than the placebo. In fact, a number of the participants were able to keep their hands in the icecold water for the 4-minute protocol limit when taking certain cotreatment formulations. It is remarkable that this endorphinergic nutraceutical formulation effectively and safely increased pain tolerance, at levels similar to that seen in prior studies with acetaminophen or lowdose exogenous opiate pain medication [23,24], even though it contained no conventional analgesics. Also noteworthy is that these formulations did not significantly alter pain thresholds or pain intensity ratings. Therefore, the therapeutic benefit of this novel endorphinergic nutraceutical appears to be its ability to allow participants to tolerate or adapt to the painful stimuli, and not necessarily alter the nociceptive experience of the pain triggered by the cold water.
Moreover, clinical observations by Dr. Steven Crain (a neuropsychotherapist with a PhD in clinical psychology and 35 years of clinical experience) of the emotional state of the participants in these "cold pressor" studies revealed unexpected, dramatic, and meaningful changes in the distress they experienced when facing this stressinducing situation. When participants were administered a combination of an Endorphin Enhancer, such as caffeine, and an Opioid Receptor Switcher, such as NAC, a remarkable reduction in emotional and physical distress—including anxiety and agitation as well as anger and irritability—was evident in the majority of the participantsespecially those who initially were the most apprehensive about the procedure. Most participants, when given this combination of agents, were clearly more relaxed and calmer with a greater sense of well-being and a more adaptive approach to the stress-induced "cold pressor" paradigm. Their cognitive functioning was intact with no side effects reported. In discussing their experience in each experimental condition, it became clear that the participants' higher pain tolerance, i.e., their ability to keep their hands in the ice-cold water longer, when administered the combination formulation was generally due to their reduced emotional and physical distress rather than a significant decrease in nociceptive pain.
These clinical "cold pressor" findings cast a new light on the earlier preclinical pain studies of Crain and Shen (Section 1), suggesting that reduced behavioral reactivity to pain-induction paradigms produced by our endorphinergic nutraceutical formulation is related more to emotional and physical distress relief than analgesia. This interpretation is consistent with observations made regarding exogenous opioids as well [
In order to explore the potential clinical implications of these exciting discoveries and insights, we initiated a 26- month clinical case study investigation, assessing the benefits of this novel endorphinergic nutraceutical formulation for individuals suffering from distress-related conditions. Through direct treatment and close clinical supervision by Dr. Steven Crain, 203 case studies (121 females, 82 males, ages 14 - 85) were conducted at Therapeutic Alliance, an outpatient psychotherapy practice he established in 1980. The key criterion for participation in this investigation was moderate-to-severe emotional and/ or physical distress that was clearly excessive and maladaptive in relation to the individual's life circumstances. In other words, their level of distress was significantly out of proportion to the actual stress in their life. This criterion was chosen since the most dramatic benefits of the endorphinergic formulation used in the cold pressor trials were observed in participants who initially were the most distressed about the stress-induced paradigm during baseline assessment. The assumption underlying this criterion is that individuals with dysfunctional distress have unbalanced endogenous opioid systems and would benefit the most from our endorphinergic formulation. Participants suffered from a wide variety of distress-related symptoms and conditions including chronic anxiety and agitation, anger and irritability, cravings and addictions, aches and pains, as well as affective, autism spectrum, personality, and attention-deficit disorders, and distressrelated medical conditions. Most of these participants had already been in intensive psychotherapy and many had either previously tried or were concurrently on psychiatric medications including anxiolytic, anti-depressant, stimulant, and pain medication as well as a variety of herbal nutraceuticals.
The nutraceutical endorphinergic formulation used in these case studies consisted of one or more Endorphin Enhancers combined with one or more Opioid Receptor Switchers. At times, other nutraceutical agents were added to the formulation, which are thought to synergize with the endorphinergic formulation and further enhance functioning of the endogenous opioid system (Endorphinergic Synergizers). For most participants, the formulation included caffeine (60 - 280 mg daily) and NAC (240 - 1200 mg daily). For those particularly sensitive to the stimulating effects of caffeine, the Endorphin Enhancer was changed to forskolin (60 - 240 mg daily). At times, a second Opioid Receptor Switcher, magnesium sulfate (60 - 480 mg daily) was added to the formulation. When needed for additional benefits, one or more Endorphinergic Synergizers were added, including L-theanine (60 - 280 mg daily) to further reduce agitation or white willow bark (200 - 800 mg daily) to reduce pain and inflammation. The participants took our endorphinergic formulation from a minimum of two months up to the entire 26 months of the research project. At times, the endorphinergic treatment was discontinued briefly and/or modified in order to more effectively assess benefits, withdrawal response, and dosing effects. Participants were also switched, at times, to single agents in order to compare their individual effects to the endorphinergic formulation. Given the extensive history with most of these participants as well as the clear documentation of the effects of prior treatment (psychotherapeutic, pharmaceutical, nutraceutical), potential placebo effects were minimized and separated from experimental treatment effects.
A remarkable and reliable set of clinical benefits of the endorphinergic formulation were reported by participants as well as observed by their psychotherapists, family members, friends, and co-workers. Nearly everyone reported at least some reduction in emotional and physical distress when using our endorphinergic formulation. Most participants felt an increased sense of calm, comfort, well-being, and positive mood while simultaneously experiencing enhanced mental clarity, energy, memory, and attention. For many participants these benefits began within the first day of taking the formulation, and continued with no signs of tolerance throughout the entire course of daily treatment. If anything, the benefits generally increased gradually over time. A consistent effect among most participants was a reduction in underlying agitation and restlessness, anxieties and worries, obsessions and compulsions, anger and irritability, cravings and substance abuse, as well as motivation and attention deficits. They simply felt more at peace with themselves and the world. With less fear and anger, participants were more able to use their cognitive abilities to approach life's challenges, instead of their prior tendency to respond emotionally and impulsively. A general trend was that the greater the participant's initial dysfunctional distress, the greater the benefits from the endorphinergic formulation.
As a result, most participants were more able to constructively change their maladaptive beliefs and behaviors, and often developed healthier and more active lifestyles, with greater control over unhealthy eating habits as well as drug, tobacco, and alcohol use, obsessions and compulsions, emotional outbursts, and social withdrawal. Desired weight loss was more easily obtained through healthier food choices and exercise. A dramatic reduction in relationship conflicts was evident, especially in couples and families. In fact, the most impressive reports came from other family members who appreciated the greater calm and constructive problem solving and perspective taking, and often encouraged the participant to continue using the endorphinergic formulation. In fact, during the investigation, there were many requests from family members and friends to take the nutraceutical formulation after observing the benefits in the participants and they were often added to the study. Overall, participants reported a more adaptive response to stressful life events. Many participants were able to reduce and/or eliminate their use of pharmaceutical and overthe-counter drugs, including anxiety, depression, pain, and stimulant medication. In fact, nearly everyone in the study eliminated his or her use of prescription anxiolytic medications while taking our endorphinergic formulation.
While at least some relief of emotional and physical distress was evident in nearly all participants, many of their problems were not immediately resolved simply by taking the endorphinergic formulation. Maladaptive beliefs, values, behaviors, and mood often continued and required further treatment, including psychotherapy, coaching, skill training, and certain medications, such as antidepressant, mood stabilizing, stimulant, and anti-psychotic drugs. For instance, the endorphinergic formulation did not automatically change irrational beliefs, such as the faulty assumption that "my plane will crash." However, the reduction in emotional distress created a much more effective mind-set to allow the individual to constructively reflect on the likelihood of this catastrophic event. In another example, after an experience with his wife's betrayal, a man could continue to perceive her as the "enemy" while using the formulation, but it facilitated his ability to forgive her for her actions, since he was not as viscerally angry. Similarly, the decision to stop overeating or drinking was not evoked by the formulation, yet it made it easier to make this choice when cravings and anxiety were reduced. While physical activity, such as running, exercise, and yoga are well-known for their mood-enhancing benefits, the endorphinergic formulation facilitated participants' ability to develop these healthy lifestyles. Therefore, it became clear that these dysfunctional patterns were more easily modified when emotional and physical distress was reduced by the endorphinergic formulation. Furthermore, the more changes participants were able to make in their maladaptive beliefs, values, and behaviors as a result of their reduced emotional and physical distress while taking the endorphinergic formulation, the greater their overall long-term improvement in life satisfaction and functioning.
This comprehensive set of benefits produced by our endorphinergic formulation had not been experienced or observed with other forms of treatment by the participants or their therapists, or when any single agent in the formation was administered alone. While synergizing agents, such as L-theanine (for agitation) or white willow bark (for inflammation), enhanced certain benefits, the simple combination of an Endorphin Enhancer with an Opioid Receptor Switcher was sufficient to produce substantial emotional and physical distress relief for most participants. For certain participants who were particularly sensitive to the stimulating effects of caffeine, the Endorphin Enhancer was switched to another agent, such as forskolin, which generally provided desired benefits. At times, adding a second Endorphin Enhancer and/or Opioid Receptor Switcher, such as magnesium sulfate, improved benefits for particularly resistant symptoms of distress.
Of particular importance is that these remarkable benefits were produced with almost no reports of significant side-effects typically seen in treatments with current psychoactive pharmaceuticals and nutraceuticals, including sedation, agitation, fogginess, gastrointestinal distress, and general malaise. There was no evidence of tolerance, withdrawal symptoms, or other signs of dependence observed throughout these case studies. Moreover, it is striking that our novel endorphinergic formulations simultaneously promoted calm, comfort, and well-being, together with enhanced mental clarity, energy, and motivation. Current psychoactive pharmaceuticals and nutraceuticals generally produce a tranquilizing or energizing benefit, often with related side-effects (sedation or agitation). By contrast, our critically formulated nutraceutical preparation, by restoring normal balance to the endogenous opioid system, appears to significantly promote healthy and adaptive emotional, cognitive, and behavioral functioning, without the sedation, agitation, or fogginess, as well as tolerance and dependence typical of most current treatments.
In order to quantify the benefits of our endorphinergic formulations, a Distress Dysfunction Inventory (DDI) was developed and given to each participant at the end of his or her participation in the study to complete and submit anonymously. The DDI contains a set of 22 distress dysfunction symptoms and conditions including "emotional distress," "physical distress," "worries and fears (anxiety)," "depressed mood," "aches and pains," "anger and irritability," and "obsessions and compulsions" as well as 9 functional characteristics including "calm and well-being," "physical comfort," "energy and motivation," and "concentration and attention." Participants were asked to rate the degree of symptom change, from "reduced" to "increased," as well as the change in functioning, from "improved" to "declined," on a 7-point Likert scale. All participants anonymously completed and returned the DDI. Scores were summarized to determine the percent of participants who experienced a change in symptoms and conditions as well as the percent of participants who experienced a change in functioning.
Following an extended period (range: 2 - 26 months; mean: 8 months) of generally daily use of our endorphinergic formulation, all of the 203 participants reported increased calm and well-being as well as concentration and attention, while more than 90% of them experienced an increase in emotional, relationship, sexual, work, and spiritual satisfaction. Nearly 90% of the participants reported increased physical comfort, while 75% of them experienced increased energy and motivation. More than 90% of the participants, who suffered from emotional distress, anxiety, obsessions and compulsions, depressed mood, anger and irritability, as well as restlessness and agitation prior to commencing the endorphinergic formulation, experienced a reduction in symptoms at the end of treatment. The same level of benefits were reported by sufferers of physical distress, aches and pains, as well as concerns about motivation, energy, concentration, and attention. Similarly, more than 90% of the participants suffering from sleep, sexual, weight, and body image concerns as well as food, alcohol, and drug cravings reported at least some improvement from taking the endorphinergic formulation. Finally, nearly 90% of those suffering from memory concerns and 80% of those suffering from gastrointestinal concerns experienced at least some improvement in these problems. These selfreport DDI findings are consistent with clinical observations of these individuals and demonstrate the remarkable benefits of our nutraceutical endorphinergic formulations across a wide variety of neuropsychiatric disorders.
Most participants, regardless of their neuropsychiatric diagnosis, experienced this comprehensive set of emotional and physical distress relief benefits from our nutraceutical endorphinergic formulations. These nutraceuticals appear to provide a safe method to enhance well-being, mental clarity, positive mood, and adaptive emotional, cognitive, behavioral, and physiological functioning. Obviously, simply taking these nutraceuticals did not typically resolve all the individual's problems, but they clearly helped most of them feel better and engage in their lives more adaptively as well as more effectively and thoughtfully work through their remaining issues. Given the wide variety of disorders, from chronic anxiety and addiction to autism and dementia, these findings are impressive and support the existence of an underlying imbalance in the endogenous opioid system, responsible at least in part for the participant's emotional and physical distress.
Inspired by the success of these clinical case studies at Therapeutic Alliance, case studies using our new endorphinergic formulation were conducted at several independent healthcare outpatient practices with similar benefits. More recently, endorphinergic nutraceutical formulations, based upon these discoveries, have been selfadministered by thousands worldwide. An analysis of DDI online survey responses from a sample of 307 of these individuals found a set of benefits almost as remarkable as that experienced under close clinical supervision (www.PonderaPharma.com). Therefore, these novel endorphinergic formulations appear to be therapeutic in both clinical treatment settings as well as more general populations. While these clinical case and survey studies were not blinded nor compared to placebos, the similarity of benefits in a variety of clinical settings, the close clinical observations by highly trained clinicians, as well as their consistency with the earlier double-blind "cold pressor" studies (Section 2) supports the validity of the effectiveness of this new generation of endorphinergic formulations in the treatment of emotional and physical distress across a wide variety of neuropsychiatric and neurodevelopmental disorders. These clinical findings are also consistent with the decades of preclinical nerve tissue culture and animal research on the endogenous opioid system (Section 1).
Our clinical studies provide important validation of the bimodal opioid receptor theory of the endogenous opioid system (Section 1) and the clinical impact of excessive excitatory opioid receptor signaling and abnormal and unstable endorphin availability. It is well accepted in the clinical and research literature that caffeine is counterindicated for anxiety and other psychiatric disorders since it tends to stimulate emotional distress and agitation [14, 26]. Paradoxically, by combining caffeine with an Opioid Receptor Switcher, such as NAC, as predicted by the bimodal opioid receptor theory, the anxiety stimulating and hyperalgesic effects of caffeine were transformed into anxiolytic and pain relief benefits. This reversal of caffeine's effect on emotional distress and pain sensitivity is consistent with, and supports the principle that sulfated agents, such as NAC and magnesium sulfate, can switch opioid receptors from the excitatory to the inhibitory mode (Section 1), thereby reducing anxiety and pain triggered by elevated endorphins (stimulated by cAMPPDE inhibitors, such as caffeine). Without an Opioid Receptor Switcher, administration of an Endorphin Enhancer, such as caffeine, alone is more likely to produce the opposite effects, i.e. emotional and physical distress, especially for individuals already predisposed to anxiety. We are not aware of any other current theory that can explain these clinical findings.
Therefore, this line of clinical and preclinical research supports the existence of an Endorphinergic Distress Syndrome (EDS), manifested clinically by a variety of emotional and physical distress symptoms, created and maintained, at least in part, by a dysfunctional imbalance in bimodal opioid receptor signaling and abnormal endogenous opioid levels. We postulate that EDS is a common neurophysiologic dysfunction that underlies many previously considered distinct psychiatric and neurodevelopmental disorders including chronic anxiety, addictions, pain, as well as affective, personality, autism spectrum, attention-deficit, and distress-related medical problems. EDS is a dysregulation of the stress response, which produces maladaptive fear, anger, cravings, and hyperalgesia. The high prevalence of EDS may explain the frequent resistance of many emotional and physical distress symptoms, including chronic anxiety, depression, addiction, and pain to conventional treatment to conventional treatment. We are not aware of any current therapy that directly addresses EDS, or attempts to resolve these underlying imbalances in the endogenous opioid system.
It is beyond the scope of this article to systematically examine the etiological factors responsible for the development of EDS, though chronic stress, trauma, genetics, drug and alcohol use, as well as other lifestyle choices may be significant factors. In particular, chronic stress and trauma appear to trigger prolonged endorphin release as an adaptive coping response, which over an extended period of time is likely to lead to mechanisms that switch opioid receptors to a protracted excitatory mode as well as depleted and/or unstable endorphin availability. It is theorized that this shift toward opioid receptor excitatory mode is part of an adaptive expectation of danger or threat in the world, based on a prolonged experience of stress or trauma. However, even when the stress and trauma are over, this neurophysiologic adaptive coping mechanism may remain, leaving the individual prone to emotional and physical distress, i.e., EDS. Genetic factors are also very important in the etiology of EDS since many people are more "wired" toward hyperexcitability and are highly reactive to perceived stressful situations, leading to a "fight-flight" coping response, including a maladaptive tendency toward fear, anger, aggression, withdrawal, and cravings, even when circumstances do not warrant this.
There is significant evidence that widely used substances, including certain drugs, alcohol, and foods, create serious and often chronic imbalances in the endogenous opioid system, potentially leading to the development of EDS. Exogenous opioid drugs, such as oxycodone, hydrocodone, and morphine, are the most widely prescribed medications in history, and their use, both legal and illegal, continues to escalate [
Nicotine and other widely used substances appear to have a similar impact on the endogenous opioid system as exogenous opioids. Nicotine has been found to modify opioid receptors and alter the synthesis and release of β-endorphin and other endogenous opioids, which is responsible, at least in part, for nicotine dependence and withdrawal [
Another factor that may be contributing to the development of EDS is our culture's excessive avoidance of sunlight, due to cancer fears as well as long indoor work hours. According to Seneff et al. [
Our preclinical and clinical findings suggest that EDS may be responsible for many of the core distress symptoms seen in a wide variety of psychiatric and neurodevelopmental disorders. If there is indeed a common neuropathology underlying these conditions, interventions that specifically target this dysfunction may be effective across a wide variety of previously considered distinct disorders. Therefore, therapeutic methods which restore healthy balance to the endogenous opioid system by concomitantly enhancing endorphin release and switching opioid receptor signaling from an excessively excitatory to a normal inhibitory mode are expected to attenuate emotional and physical distress in these clinical disorders.
Clinical research and experience suggest that effective healthy lifestyle choices, including adaptive stress management strategies, positive outlook on life, routine exercise and exposure to sunlight, minimal use of prescription and OTC pain drugs as well as alcohol and nicotine, and a diet focused on whole natural foods and beverages (e.g., low gluten, casein, dietary sugar, sugar substitutes, and MSG) are among the best natural methods to prevent and treat EDS. However, our case studies reveal how difficult it is to maintain these healthier behaviors and attitudes, since the neurophysiologic imbalances underlying EDS create such emotional and physical distress that it is challenging to relax sufficiently to rationally handle stress adaptively. This is especially problematic for people who have experienced trauma and chronic stressful life circumstances as well as those genetically prone toward endogenous opioid system imbalances.
In addition, EDS produces a dependency on, and cravings for substances that dysfunctionally impact upon the endogenous opioid system, including alcohol, nicotine, pain drugs, processed sugar, unbalanced caffeinated beverages, "comfort foods," and certain food additives. In fact, when opioid receptors are switched to a protracted excitatory mode, methods that stimulate endorphins, such as exercise, are more likely to produce distress than pleasure, leading to avoidance of healthy activity. This vicious cycle potentiates EDS since unbalanced endogenous opioid systems lead us to experience emotional and physical distress. This increased distress greatly enhances our interpersonal conflicts, maladaptive stress-coping strategies, and cravings for comfort foods, beverages, and drugs, thereby exacerbating our anxiety, anger, cravings, depression, hyperalgesia, aggression, and withdrawal. Our case studies reveal that, at times, this vicious cycle can only be broken by methods that directly restore healthy homeostatic balance in the endogenous opioid system. Therefore, our endorphinergic formulation appears to be necessary to treat EDS for many people who suffer from emotional and physical distress.
Ever since the discovery of opioid receptors and "endogenous morphine," or "endorphins," as Eric Simon named them, many have envisioned that the "Holy Grail" would be therapeutic regulation of these amazing "molecules of emotion" [38,39]. With our discovery of EDS and a method to restore healthy balance in the endogenous opioid system, our research offers promise of a remarkably safe and effective treatment for the emotional and physical distress symptoms underlying a wide variety of psychiatric and neurodevelopmental disorders, including chronic anxiety, anger, addictions, hyperalgesia, as well as affective, autism spectrum, attention-deficit, and personality disorders. Our endorphinergic treatment may also help to prevent and treat stress-related illnesses. By combining Endorphin Enhancers, such as caffeine and/or forskolin, to insure sufficient and consistent endorphin levels, with Opioid Receptor Switchers, such as NAC and/or magnesium sulfate, to restore normal inhibitory opioid receptor signaling, critically formulated nutraceutical and pharmaceutical preparations may provide a novel method to correct neurophysiologic imbalances in the endogenous opioid system.
It is interesting to note that our endorphinergic formulation worked so effectively with such a wide variety of distress symptoms and disorders, especially since prior studies have shown that distress conditions may involve abnormally low or high endorphin levels (Section 1). Our case studies suggest that regardless of the endorphin imbalance, the inclusion of an Endorphin Enhancer is generally beneficial. This finding may be explained by the homeostatic nature of the endogenous opioid system. Preclinical studies [16,18] have shown that excitatory opioid receptor signaling tends to promote endorphin levels by increasing cyclic AMP and neurotransmitter release, which may enhance endorphin release in some parts of the nervous system. This evidence suggests that when an Opioid Receptor Switcher restores normal inhibitory signaling, endorphin production is likely to decrease. Therefore, regardless of whether endorphins initially are abnormally high or low, administration of an Endorphin Enhancer is generally needed to insure sufficient and reliable endorphin availability at the same time that normal inhibitory opioid receptor signaling is restored by the Opioid Receptor Switcher.
With a balanced endogenous opioid system, we are generally less emotionally and physically distressed and more able to respond to stressful situations appropriately and adaptively without self-defeating struggles and conflicts or reliance on "comfort" drugs and alcohol or foods and beverages. By reducing these maladaptive coping strategies and substances, EDS is further reduced, leading to a healthier, more satisfying and enjoyable life. However, it is important to note that while these endorphinergic nutraceuticals appear to be effective for EDS, they are not a treatment for medical disease conditions. Therefore, our endorphinergic formulations should only be considered as part of a comprehensive treatment program that targets dysfunctional emotional and physical distress. Obviously, these new generation nutraceuticals appear to have remarkable benefits for individuals who suffer from EDS, that is, an underlying imbalance in their endogenous opioid system, manifested by excessive emotional and physical distress. For these individuals, the restoration of healthy homeostatic balance in the endogenous opioid system, essentially tuning down fight-flight distress alerts, facilitates more effective "top-down" regulation between our emotion centers, where endorphins are concentrated, such as the limbic system and the gut's "second brain," and our higher cognitive processes in the prefrontal cortex. By enhancing "top-down" regulation, our endorphinergic formulation provides a therapeutic tool in the treatment of a wide variety of distress-related conditions.
It is not expected that this formulation will have much immediate benefit to those who already have a balanced endogenous opioid system, though regular use of these endorphinergic nutraceuticals may help prevent the development of EDS. Another way to prevent EDS on a large-scale basis might be the systematic addition of an Opioid Receptor Switcher, such as NAC or ULDN, in all drugs, foods, and beverages that may trigger excessive excitatory opioid receptor signaling, including opiate drugs, acetaminophen, certain respiratory medications, (e.g., cAMP-PDE inhibitors, such as roflumilast and theophylline), nicotine and alcohol products, caffeinated and sweetened foods and beverages, as well as specific food additives (e.g., excitatory amino acids, as in aspartame and MSG).
Autism Spectrum Disorder (ASD) provides an excellent illustration of the application of our bimodal endorphinergic theory to a specific clinical condition since there are a number of lines of evidence that suggest that many ASD symptoms stem from early-onset EDS produced by both genetic and environmental factors. Panksepp [
These biochemical assays in ASD children provide support for our bimodal endorphinergic theory suggesting that EDS may be a critical factor in producing the distress symptoms in ASD. In addition, opiate antagonists at doses that block both excitatory and inhibitory opioid receptor signaling have been shown to provide some, albeit inconsistent, benefits for ASD children, demonstrating involvement of the endogenous opioid system [
While the endogenous opioid system plays a central role in our adaptive response to stress and imbalances in this system appear to be responsible for many distress symptoms, it has complex homeostatic inter-connections to other stress-related neurotransmitter systems, such as dopamine, glutamate, serotonin, GABA, and norepinephrine [
While our choice of NAC as an Opioid Receptor Switcher for our formulations was based on its sulfation effects on the endogenous opioid system [17,21], it also directly modulates other stress-related neurotransmitters including dopamine and glutamate [
We postulate that the endogenous opioid system serves as the central alert system, informing the individual of the relative safety (inhibitory opioid receptor mode), or threat (excitatory opioid receptor mode) from the environment or one's own body. The release of endogenous opioids triggers inhibitory (calming) or excitatory (distressing) opioid receptor signaling, which then homeostatically stimulates the other neurotransmitter systems, together producing the full range of emotions, cognitions, and behaviors relevant to the specific circumstances. Dysfunctional endorphinergic imbalances, such as opioid receptors abnormally switched to the excitatory mode, reflect a dispositional bias to the perception of danger or threat, thereby producing distress symptoms of EDS. Endorphinergic therapeutics that restore healthy balance to the endogenous opioid system are likely to directly reduce these EDS symptoms. In view of the complex interconnected stress adaptation system, however, interventions that target other neurotransmitter systems, such as SSRIs, are likely to indirectly impact the endogenous opioid system, thereby producing distress-relieving benefits as well. Our theory suggests that methods which restore healthy homeostatic balance in the endogenous opioid system, including both sufficient endorphin availability and normal inhibitory opioid receptor signaling, may provide direct resolution of the central neurophysiologic dysfunction and, therefore, more extensive relief from emotional and physical distress. Once normal balance is restored in the endogenous opioid system, homeostasis is likely to promote healthy balance in the other neurotransmitter systems as well. In this way, healthy emotional, cognitive, behavioral, and physiological regulation is restored. Thus, a well-functioning balanced endogenous opioid system provides resilience and an adaptive stress response including effective higher-order cognitive functioning and a generally positive hedonic tone with less interference by more primitive "fight-flight" reactions, such as maladaptive fear, anger, and cravings. Simply put, stress does not have to produce distress.
Obviously, these clinical studies have been exploratory and need further investigation. Future research can elucidate and validate the existence and nature of endogenous opioid system imbalances and their role in causing EDS, and the extent to which a common endorphinergic dysfunction underlies many of the distress symptoms typically associated with psychiatric, neurodevelopmental, and distress-related medical conditions. These studies could clarify which of the endogenous opioids, such as β- endorphins, and their primary locations in the nervous system, such as in specific regions in the brain or gut, are more critically involved in EDS. This research should also explore the complex relationships among the important stress-related neurotransmitter systems, including endorphin, glutamate, dopamine, GABA, norepinephrine, and serotonin in order to determine the most effective levels of intervention. The existence and nature of genetic dispositions toward EDS need to be studied, such as ASD and other conditions with early onset emotional and physical distress, and their interface with trauma, chronic life stresses, and lifestyle choices.
Systematic large-scale clinical trials as well as more targeted double-blind, placebo-controlled studies will help validate and refine the use of our novel critically formulated endorphinergic formulations, consisting of one or more Endorphin Enhancers and one or more Opioid Receptor Switchers, with possible Endorphinergic Synergizers, for the prevention and treatment of EDS. Investigation of functionally relevant nutraceutical and pharmaceutical agents and their combinations, as well as dosing, will be important. For instance, the combination of a specific cAMP-PDE4 inhibitor, such as roflumilast, with ULDN, should be considered as a potent pharmaceutical treatment for EDS. Further research is also suggested that can evaluate the benefit of these endorphinergic therapeutics as a safe method to enhance well-being, mental clarity, positive mood, and adaptive emotional, cognitive, behavioral, and physiological functioning. Finally, the longterm effects of these endorphinergic formulations need to be explored, including their lasting benefits after discontinuation. Further research is needed to study the role of changes in beliefs, behaviors, and values made while taking the formulation in facilitating and synergizing long-term benefits.
Clinical research, including neuroimaging, biochemical, and pharmacologic analyses, should be designed to systematically investigate the specific imbalances in the endogenous opioid system, including maladaptive opioid receptor signaling and endorphin levels that underlie each EDS cluster to determine whether specific neurophysiologic profiles exist. For instance, certain disorders may involve excessive endorphins, such as autism, while depleted endorphins may be implicated in other conditions, such as post-traumatic stress disorder. Similarly, while most distress conditions are likely to involve excessive excitatory opioid receptor signaling, there may be others that could stem from excessive inhibitory signaling, such as certain catatonic states. Once these specific profiles are determined, and assessment methods are established, more critically targeted endorphinergic formulations can be developed. Finally, neuroimaging, biochemical, and pharmacologic analyses can be used to determine the specific impact these endorphinergic treatments have on the central and peripheral nervous systems, especially regarding changes in "top-down" processing of stressful events.
Systematic methods need to be developed for the prevention of EDS. Studies should address the positive impact on the endogenous opioid system of teaching effective stress management techniques, especially in early childhood education. Identification of vulnerable children and adults, due to more serious stress, trauma, and genetic factors, for such programs would be important. Research is also suggested to investigate health benefits of natural endorphin enhancing lifestyle choices, such as routine exercise, relaxation, and sun exposure, as well as potential risks of drugs, foods, and beverages that may trigger excessive excitatory opioid receptor signaling, including opiate drugs, acetaminophen, certain respiratory medications, nicotine and alcohol products, caffeinated and sweetened foods and beverages, as well as specific food additives. While minimizing use of these popular substances could reduce endorphinergic imbalances, studies should also address the possible benefits of routinely adding Opioid Receptor Switchers to them in order to help prevent the development of EDS.


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Home > War Games & Miniatures > Para Bellum Wargames
Model: PBW7332Bar Code: 5213009010313Brand: Para Bellum Wargames
Released 04/01/2020
While the clamor of war spreads, the wisest amongst those living fear the rising of the Dweghom. Deep in their Holds, they hear the clamor of battle approaching and feel the pulse quicken in their veins. They are the eldest disciples of War. The last time their Hosts marched to battle, the eternal reign of Dragons came to an end in a conflict so violent the land itself withdrew.
Resin miniature with 27 mm plastic base and 1 iCard for the Tabletop Game "Conquest: The Last Argument of Kings.
Miniatures supplied unassembled and unpainted. Glue and paints required.
Release date January 2020. May be subject to change.
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Research Administrator
- Recruiter
- Location
- Bristol, United Kingdom
- Salary
- £23,754 - £26,715 per annum
- Posted
- 20 Sep 2019
- End of advertisement period
- 06 Oct 2019
- Ref
- Contract Type
- Permanent
- Hours
- Full Time
Division/School Research Development
Contract type Open Ended
Working pattern Full time
Salary £23,754 - £26,715 per annum
Closing date for applications 06-Oct-2019
We are looking for a well-organised, confident and proactive research administrator with strong communication and interpersonal skills to support the Bristol Digital Futures Institute (BDFI). This new flagship Institute will transform the way we understand and create digital technologies for economic and social prosperity in future societies.
You will plan activities undertaken within BDFI and provide support to academic staff, researchers, postgraduate students and project partners. This is a varied role and tasks will include: budget monitoring; maintaining project websites; project administration and reporting; event management (from meetings to conferences); organising travel and research meetings, gathering information and copy for marketing materials and future research bids; managing key relationships across the University and with external contacts. This opportunity would suit an enthusiastic and self-motivated individual who is comfortable working on a varied portfolio of projects and activities and is able to plan and prioritise workloads successfully.
The position is offered on a full-time basis with an open-ended contract and guaranteed funding until 30.09.2020. Subject to funding availability, the post will be extended.
Informal enquiries can be made to: Maria Korea, Smart Internet Lab Manager, email@example.com.
For further information about the Bristol Digital Futures Institute:
We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.
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05 Oct 2015
Parisians proved that the denim dress is going nowhere from the trend sphere soon
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By: Danielle Hatch
On June 24, 2019 President Trump signed an executive order imposing sanctions that targeted Iranian Supreme Leader Ayatollah Ali Khamenei and other top Iranian officials. The move came after Tehran's downing of an unmanned American drone last week. Some are saying that the attack was initiated to try and get the US to ease the current sanctions that were imposed after the US left the Joint Comprehensive Plan of Action (JCPOA).
The goal of these new sanctions is to keep top Iranian officials from using international banking systems or financial vehicles set up by European nations or other countries. OFAC is also imposing sanctions on eight Iranian military commanders that were responsible for the downing of the US drone.
Executive Order: https://www.whitehouse.gov/presidential-actions/executive-order-imposing-sanctions-respect-iran/


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Seven people were injured in two separate accidents on Interstate 29 in Platte County on Thursday, Aug. 8, according to the Missouri State Highway Patrol.
The first occurred at 1:02 p.m. near mile marker 13 in the southbound lane.
A 2008 Chevrolet Malibu driven by Michael A. Young, 29, of Independence, traveled off the roadway, struck a guardrail, overturned and then caught fire.
Injured the accident was Young and Britney B. Gordon, 29, of Kansas City. Both suffered minor injuries and were transported to North Kansas City Hospital. A second passenger, Michael A. Young, Jr., 3, was also transported to the hospital but without injuries.
The Platte County Sheriff's Office and the Kansas City Fire Department assisted on the scene.
At 5:55 p.m. that night, another accident happened in the southbound lane, north of the 112th Street exit.
This three-vehicle accident occurred when a metal object was dropped from a commercial vehicle and caused a 2018 Nissan Altima driven by Nurris Perez Benitez, 51, of Kansa City, Mo., and a 2004 Honda Pilot driven by Erik L. Waters, 26, of Platte City, to stop suddenly.
Benitez's car struck Waters' vehicle. A 2003 Honda Pilot driven by Jalen L. Redmond, 23, of Kansas City, then struck Benitez's car, which in turn hit Waters for a second time.
The four injuries in this accident were all in Benitez's car. He suffered moderate injuries, while passengers Yanesis L. Rojas, 33, Yamila Rondon, 51, and Miriam Tzintzun Silva, 57, all of Kansas City, sustained minor injuries.
All four were transported to North Kansas City Hospital.


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What Alyssa would like to know about your dog
I would like to know if he or she doesn't like other dogs, if they need any medications, if they prefer taking certain routes for walks.


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Fine Coaching Counseling
Close Encounters of the Worst Kind: The Narcissistic Abuse Survivors Guide to Healing and Recovery
Recent Posts
- How to Be Authentically You October 5, 2019
- Holding Out Hope for Your Narcissistic Family September 9, 2019
- You Are Worthy You Are Loved July 29, 2019
Narcissistic Personality Disorder
- Holding Out Hope for Your Narcissistic Family
- You Are Worthy You Are Loved
- The Narcissistic Abuse Addiction Connection
- What the @#$%? is Wrong With My Family
- Narcissistic Triangulation Sabotages Sibling Relationships
- The Process of Narcissistic Parental Alienation
- The Narcissistic Mothers Accomplice
- Twenty Questions Determine If You Have an Enabling Parent
- Breaking Up With a Narcissist
- How Enablers And Flying Monkeys Fuel Narcissistic Abuse
- Invisible Trauma of Childhood Abuse
- World Narcissistic Abuse Awareness Day June 1st
- Mothers Day Joyful For Some Dreadful For Others
- Ten Things to Know Before Confronting Your Narcissistic Abuser
- Changing Inner Dialogue Crucial for Narcissistic Abuse Recovery
- Healing the Core Wounds of Narcissistic Abuse
- Ten Tips Prevent Narcissistic Re-victimization
- 10 Reasons Some People Just Can't Let Go of an Ex
- Narcissists: Finally the Truth About Who They Really Are
- Attributes of the Narcissistic False Self
- Twenty Signs Your Abuser is a Narcissist
- If You Are Dreading Valentine's Day You Are Not Alone
- Poll: Who Is or Was Your Narcissistic Abuser(s)
- Why Is It So Hard To Leave Your Narcissistic Abuser
- What It Means When a Narcissist Says "I Love You"
- Feeling Isolated in the Aftermath of Narcissistic Abuse
- Is Your Abuser a Narcissist
- How to Spot a Narcissist on the Prowl
- Strategies Tips and Tactics for Dealing with NPD Abuse
- Is Your Inner Dialogue Keeping You Stuck In Pain
- Broken Sons of Narcissistic Mothers
- Taking Back Control From Your Narcissistic Abuser
- Are You Being Spiritually Abused by a Narcissist
- Help Has Arrived for Narcissistic Abuse
- Narcissists Lie But Your Intuition Never Does
- Impact of Verbal Abuse Quote
- Master Class Interview with Randi Fine
- Emotional Relationship Boundaries
- Passive Aggressive Behavior is Covert Abuse
- Turning Triggers Into Treasures
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Tag Archives: Life
Twenty Personal Choices Determine How Happy You Are
Photo Image Credit Twenty Choices You Can Make to Increase Happiness Written by Randi Fine, Narcissistic Abuse Counselor and Author of Close Encounters of the Worst Kind: The Narcissistic Abuse Survivor's Guide to Healing and Recovery In our pursuit of … Continue reading
Posted in Happiness, Polls, Quizzes, Surveys, Positive Thinking Tagged choices, Happiness, Happy, Life, randi fine Leave a comment
Why Is Life So Difficult
Facing Life's Challenges Written by Randi Fine Have you ever asked yourself, "What am I doing all this for? Why is life such a struggle? What am I accomplishing?'" I believe we are souls housed within a human body; eternal … Continue reading
Posted in Adversity, Life, Personal Growth Tagged Adversity, challenges, evolving, Life, soul Leave a comment
Rising Above Narcissistic Victimization
Pain is Mandatory, Suffering is Optional Article Written by Randi Fine Author of Close Encounters of the Worst Kind: The Narcissistic Abuse Survivor's Guide to Healing Most of us have been, victimized many ways in our lives; emotionally, mentally, physically, … Continue reading
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Dealing With the Curve Balls of Life
Image Source When Life Throws You a Curve Ball Embracing Unpredictability Daily OM Post Written by Madisyn Taylor When the unexpected happens, you always have your inner core strength which cannot be taken from you. In life, we are always … Continue reading
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We Are All Here to Learn
Life Packaging The Gift Inside by Madisyn Taylor Daily OM We are all spiritual beings living in a human body even though our packaging seems different, we are very much the same. We have all had the experience of encountering someone whose … Continue reading
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Over the last 500 million years or so, life on Earth has been threatened on many occasions; the fossil record is littered with extinction events. What's curious about these events is that they seem to occur with alarming regularity.
The periodicity is a matter of some controversy among paleobiologists but there is a growing consensus that something of enormous destructive power happens every 26 or 27 million years. The question is what?


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Supreme Court appoints four new judges
The judges are likely to be sworn-in to the position on Monday
Four different High Court Chief Justices were appointed as judges of the Supreme Court, taking the judge strength of the apex court to 34, the highest ever.
The oath ceremony is likely to take place next Monday.
The four new judges of the top court are Himachal Pradesh Chief Justice V. Ramasubramanian, Punjab and Haryana Chief Justice Krishna Murari, Rajasthan Chief Justice S.A. Ravindra Bhat and Kerala Chief Justice Hrishikesh Roy.
The central government has cleared their appointment as Supreme Court judges and President Ram Nath Kovind has appointed them as judges of the top court. The Supreme Court collegium last month recommended the Centre to elevate four Chief Justices of different high courts to the apex court. The collegium has said against the sanctioned judge strength of 34, the Supreme Court is currently functioning with 30 judges, leaving four vacancies.
While recommending the names of Justice Krishna Murari, Justice S. Ravindra Bhat, Justice V. Ramasubramanian, and Justice Hrishikesh Roy, the collegium has taken into consideration combined seniority on all-India basis of Chief Justices and senior puisne Judges of High Courts, apart from their competence, conduct and integrity.
Justice Ramasubramanian, born on June 30, 1958, did his Bachelor's in science from Vivekananda College in Chennai and Law from the Madras Law College, before enrolling as a member of the bar on February 16, 1983. After practising for almost 23 years in the Madras High Court, he was appointed Additional Judge of the Madras High Court on July 31, 2006 and as a permanent Judge on November 9, 2009.
He was transferred at his own request to the High Court of Judicature at Hyderabad for Telangana and Andhra Pradesh with effect from April 27, 2016. After the bifurcation and the creation of a separate High Court for Andhra Pradesh, he was retained as a Judge of the High Court of Telangana at Hyderabad with effect from January 1, 2019. He was sworn in as the Chief Justice of Himachal Pradesh High Court on June 22, 2019. Justice Murari, born on July 9, 1958, did his law degree from the Allahabad University, and was enrolled as an advocate on December 23, 1981.
Practising in the Allahabad High Court for over 22 years in civil, constitutional, company, service and revenue matters and specialising in civil revenue and service cases, he was Standing Counsel of Uttar Pradesh State Yarn Co Ltd, Kanpur, Northern Railway Primary Co-operative Bank Ltd, UP State Textile Corporation Ltd, Kanpur, UP Co-operative Spinning Mills Federation Ltd, Kanpur and Bundelkhand University, Jhansi.
Appointed as an Additional Judge of the Allahabad High Court on January 7, 2004 and appointed a permanent Judge on August 18, 2005, he took over as Chief Justice of Punjab at Haryana High Court on June 2, 2018.
Also Read: Supreme Court sets October 18 deadline for completion of Ayodhya hearing
Justice Bhat, born in 1958, graduated in law from Campus Law Centre of the Delhi University and enrolled with the Delhi Bar Council the same year. After practising before the Delhi High Court and the Supreme Court, he was appointed an Additional Judge of the Delhi High Court in 2004 and a permanent Judge in 2006. He was appointed Chief Justice of the Rajasthan High Court on May 5 2019.
Justice Hrishikesh Roy was sworn-in as the 35th Chief Justice of the Kerala High Court on August 8, 2018 after being its Acting Chief Justice since May 30, 2018, on his transfer from the Gauhati High Court. Born on February 1, 1960, he did his LL.B from Campus Law Centre of the Delhi University in 1982. He practiced in the Gauhati High Court and was designated as a senior advocate on December 21 2004. Sworn in as an Additional Judge of Gauhati High Court on October 12, 2006, he was made a permanent judge with effect from July 15, 2008.
As the executive head of the Assam State Legal Services Authority, Justice Roy had implemented the "Reach Out & Respond" programme to facilitate access to justice for the marginalised sections of the state. He was also in-charge of the Assam chapter of the Indian Law Institute.
Spearheading the training programmes for the Judicial Officers under the Gauhati High Court, he was nominated as a member of the National Judicial Academic Council, headed by the Chief Justice of India.
While he headed the Mediation Monitoring Committee, the film "Shako" (Bridge) was produced and is used as a training tool in mediation programmes. The Arunachal Pradesh Legal Services Authority, led by Justice Roy, produced 'Apne Ajnabi', a short film on racial discrimination which highlights how legal help can be provided to the victims.
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Baba Siddique's Son Pitted Against Sena Veteran In Bandra East


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Inspired by the great blue herons that can be seen by the Ballard locks and waterfront parks in Seattle.
This is a 10" x 14" two-color silkscreened poster. It is hand-printed with water based inks on heavy French Paper Company "Carbon Copy Kraft" 100# grey cover stock. The first print layer uses a metallic gold ink.


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Megaboots 2015 is a photograph by Joan Carroll which was uploaded on May 22nd, 2015.
More from Joan Carroll
Comments (267)
Thank you Starving Artist for the feature in the Starving Artist Photographers group!
Thank you Colleen!
Congratulations on your latest sale Joan! :)
Congrats on your sale!
thank you Judy!
Congratulations on your sale!
I love this...congrats on your sale!
thank you Karen!
thanks so much the the buyer in Stockton CA for purchasing a copy of this print!
Beautifully done Joan! I love this!
thank you Paul!
Joan, Great detailed cowgirl boots next to the detailed flower, L/F
thank you Judy for the feature in the USA Photographers Only group, 9/25/17
thank you tina for the feature in the A B F A Platinum group, 9/21/17
thank you Stefano for the feature in the 10 Plus group, 9/8/17
I have my very own pair i love over here in NZ..l,f
thank you Karin! you have fat babies! fantastic!
CONGRATULATIONS! Your awesome work has been featured in Pretty in Pink Blue or Purple!. Thank you so much for contributing your talent to our highly ranked group! You're invited to post your dated image in the features thread. As always, I have faved and tweeted all featured images. Please visit your colleagues' features and promote your favorites by clicking fave as well as icons to the right of the artist's image if you wish. To easily find our group, just click on the features icon beneath your image and it will take you right there. Have a blessed Day! Maggie l
thank you Maggie!
thank you Maggie for the feature in the Pretty In Pink Blue Or Purple group, 8/29/17
This would be beautiful on a canvas print. L/F/G+
Love this on a wood print. L/F
thank you Terry!
thank you Sergey!
thank you Luther fine Art for the feature in the ABC group - P is for Pink group, 9/20/16
Absolutely LOVE this!
thank you Teresa!
thank you Darren for the feature in the 2 A Day Photos Turned Into Paintings group, 5/15/16
Congrats on your Sale!!
thank you Colleen!
Congrats Joan!
Congrats joan!
thank you Guido!


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(and with HJC in the background)
1. "Manhattan Beach" - Jennifer Egan - Give me a book that's just about Eddie and the bosun.2. "Dark Sacred Night" - Michael Connelly - Connelly finally puts Bosch and Ballard together and I like it.3. "My Own Devices: Essays From the Road on Music, Science, and Senseless Love" - Dessa - I first heard about Dessa during Barb during her MPR days. I saw this book on the NPR book thingy and thought I would check it out. Parts of this book will definitely stick with me for a long time. I love the way her mind works, even if it seems to work against her in some aspects of her life.4. "Come with Me" - Helen Schulman - Slooooooooooow start but I finally connected with the book in the final quarter. But, it took me all month (and about a week and a half of late fines from the library) to finish it.5. "The Heart's Invisible Furies" - John Boyne6. "Still Me" - Jojo Moyes7. "To All the Boys I've Loved Before" - Jenny Han8. "P.S. I Still Love You" - Jenny Han9. "Always and Forever, Lara Jean" - Jenny Han10. "The Wedding Date" - Jasmine Guillory - I wanted something and light and found this recommendation from Roxane Gay. I flew through the book. Definitely light and LUSTY.11. "Rich People Problems" - Kevin Kwan12. "We're Going to Need More Wine" - Gabrielle Union 13. "Eleanor Oliphant is Completely Fine" - Gail Honeyman - I found myself crying a lot while reading this book. She really pulls you into the loneliness of this character.14. "The Proposal" - Jasmine Guillory - I had so much fun with her first book that I hopped onto the second one, which follows a secondary character from her first book.15. "The Bride Test" - Helen Hoang - This was recommended for folks who liked the Jasmine Guillory books. I was not disappointed. I'm embracing my sudden need for somewhat trashy novels.16. "The Lager Queen of Minnesota" - J. Ryan Stradal - Life's what happens while you're busy making other plans.
1- i'm a stranger here myself- bill bryson2- oh crap! Potty Training: Everything Modern Parents Need to Know to Do It Once and Do It Right- jamie glowacki3- sideshow usa: freaks and the american cultural imagination- rachel adams4- bhagavad gita- translated and commentary by ac bhaktivedanta swami prabhupada5- lord of light- roger zelazny6- uncle's dream- dostoyevsky7- infinite jest- david foster wallace8- the complete works of pseudo dionysius9- nigger of the narcissus- joseph conrad 10- the ascent of money- niall ferguson


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International Photogrammetry and Remote Sensing Community Gathers in Enschede - 13/06/2019
The ISPRS Geospatial Week is being held in the Dutch city of Enschede this week (from 10-14 June). The city is home to the internationally respected University of Twente, which is also the venue for this year's gathering of geospatial professionals from across the globe. Whether to attend a presentation on 'Façade Reconstruction for Textured LOD2 CityGML Models Based on Deep Learning and Mixed Integer Linear Programming' or to meet up with fellow Lidar specialists from Down Under and elsewhere around the world, numerous delegates have travelled to the ISPRS Geospatial Week for a thorough update on what is going on in the exciting and innovative field of photogrammetry and remote sensing.
The topics being discussed throughout the week range from the quality of image-based point clouds from UAV imagery to a SLAM-based approach to mobile robot navigation. The applications being covered vary from urban planning and land administration to agriculture and forestry.
The conference programme comprises five different tracks throughout the day, resulting in a choice of over 275 oral presentations and more than 100 poster presentations. Delegates benefit from a first-rate overview of the scientific advancements thanks to the combination of the technical sessions and the exhibition. This edition of the ISPRS Geospatial Week also incorporates the UAV-g 2019 event.Last updated: 14/10/2019


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Johnny Depp Naked Leaked Photos Updated: April 3, Tom Johnny Depp, Movie Actor, Nude Male Celebs Leave a comment One of the most legendary sexiest men in Hollywood got his photos .
"Johnny Depp Nude Leaked Photos" Gallery. Five nude photos (apparently "hacked" from his phone) have surfaced and spread across the internet: The nude figures photos were probably taken by the actor with his phone, during a visit at the Louvre Museum in Paris earlier this month.
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Johnny Depp is one of the finest actors of his generation. He also has one of the finest tushes of his generation. Depp got his start with a small role in the now iconic A Nightmare on Elm Street ().
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text: Littlewoods Buy Now Pay Later – IT'S ALL ABOUT NEW! get your winter styled up Mr. SaniNovember 3, 2018November 3, 2018 We're feeling oh-so-snuggly with the new drop of teddy coats, checks, animal prints and more Autumn Price Drop – Up to 40% OFF – selected fashion & sportswear We've all seen them styled by our favourite It girls, and you've probably even tried one on, only to quickly put it back on the rack. Sure, oversize shirts are a pretty cool trend, but they're also not as easy to wear as you might have thought. After all, there's a whole lot more fabric to work with.But don't give up on the idea just yet! We've done some research to see exactly how street style stars make them work, and we've come back with plenty of styling advice. Ahead, take a look at all the different ways you could wear this tricky trend, and get ready to become the coolest girl in the room. (Visited 18 times, 1 visits today)


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Confusion abounded in the still-smoldering South about the precise meaning of "freedom" for blacks. Emancipation took effect haltingly and unevenly in different parts of the conquered Confederacy. As Union armies marched in and out of various localities, many blacks found themselves emancipated and then re-enslaved. Blacks from one Texas county fleeing to the free soil of the liberated county next door were attacked by slave owners as they swam across the river that marked the county line. The next day trees along the riverbank were bent with swinging corpses – a grisly warning to others dreaming of liberty. Other planters resisted emancipation more legalistically, stubbornly protesting that slavery was lawful until state legislatures or the Supreme Court declared otherwise. For many slaves the shackles of slavery were not struck off in a mighty single blow but had to be broken link by link.
Prodded by the bayonets of Yankee armies all masters were eventually forced to recognize their slaves' freedom. Some blacks initially responded to news of their newly granted freedom with suspicion and uncertainty. Loyalty to the plantation master prompted some slaves to resist the liberating Union armies, while other slaves' pent up bitterness burst forth violently on the day of liberation. Many newly emancipated slaves, for example, joined Union troops in pillaging their masters' possessions. Many took new names in place of the ones given by their masters and demanded that whites formally address them as "Mr." or "Mrs."
Tens of thousands of emancipated blacks took to the roads, some to test their freedom, others to search for long-lost spouses, parents, and children. Emancipation thus strengthened the black family, and many newly freed men and women formalized "slave marriages" for personal and pragmatic reasons, including the desire to make their children legal heirs. Other blacks left their former masters to work in towns and cities, where existing communities provided protection and mutual assistance.
The church became the focus of the black community life in the years following emancipation. As slaves, blacks had worshiped alongside whites, but now they formed their own churches pastored by their own ministers. Black churches grew robustly. The 150,000 member black Baptist Church of 1850 reached 500,000 by 1870, while the African Methodist Episcopal Church quadrupled in size from 100,000 to 400,000 in the first decade after emancipation. These churches formed the bedrock of black community life, and they soon gave rise to other benevolent, fraternal, and mutual...


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Vawdry future driven as the largest independent trailer builder in Australia
Vawdrey is the largest independent trailer builder in Australia. With year-on-year sales trending upwards, the company is committed more than ever to delivering world-class manufacturing…Read Morearrow_forward
A pioneer in payload potential
Visy Logistics is trialling a unique Performance-Based Standards–approved curtainsider from Vawdrey Australia that enables optimal fleet versatility via ingenious side and top-loading design. (more…)Read Morearrow_forward
Success through versatility
From fresh produce to carpets, plants and everything in between, Exodas Transport is a diverse business that requires flexibility in its equipment. Vawdrey Australia's ability…Read Morearrow_forward
Laying it on the LatchLiner
The acquisition of three new Vawdrey LatchLiner B-doubles has considerably bolstered the Bedggood's Transport fleet. The company specialises in the local and interstate haulage of…Read Morearrow_forward
Less is more
Combining lightweight construction with enhanced strength and capabilities, Owens Transport's newest Performance-Based Standards–approved quad super B-double skels from Vawdrey Australia are helping the fleet to…Read Morearrow_forward
The perfect solution
Transporting goods across Bass Strait, CRE Solutions' fleet is subjected to tough and corrosive conditions which are unique to the Trans Bass operation. However, its…Read Morearrow_forward
A cool change
With a view to expanding into different markets while ensuring optimised fleet utilisation, Mildura-based GTS Freight Management has recently commissioned two new Vawdrey insulated curtain-side…Read Morearrow_forward
Taking the lead
K&S Corporation has recently commissioned a large volume order of curtainsiders and dollies supplied by Vawdrey. The units will see service in Western Australia. (more…)Read Morearrow_forward
Spreading the word
For Australia Post, safety is at the heart of all of its operations, and the safety of its people comes first. With its latest delivery…Read Morearrow_forward
Through thick and thin
When it comes to its trailer fleet, Hannah's Haulage believes consistency and brand loyalty go a long way. Its strong partnership with trailer builder, Vawdrey…Read Morearrow_forward


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Mu1 assignment 2 guide cga
Mu1 assignment 2 guide cga
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text: 4 reasons why taking pictures of yourself (even 25,000 of them) isn't as silly as it sounds. Erica Williams Simon 09.25.15 What could you do with 54 hours? Go ahead. I'll give you a minute to think. Keep Reading Show less humanity and culture diversity culture selfies selfie positive body image self-affirmation identity Most Shared