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Ford Motors has added to its vast collection a limited-edition of Ford Ranger Fx4.
The Ranger Fx4 is based on the segment-defining 3.2-litre XLT Double Cab 4×4, and introduces an attention-grabbing array of styling enhancements.
"The Ranger Fx4 fills a unique space in our current line-up as it offers our valued Ranger customers a vehicle that has been personalized as part of our standard manufacturing process," said Kagwiria Mbiti, Head, Ford Operations at CMC Motors Limited.
He added that a strong demand for accessorizing and customizing the standard Ranger amongst enthusiast customers, is the niche Ranger Fx4 fills, while maintaining the exceptional capabilities of the XLT model.
The Ranger Fx4 incorporates a number of distinctive styling changes, including attractive black finishes for the radiator grille, fog lamp bezels, exterior mirrors, roof rails, as well as the door and tailgate handles.
The 17-inch alloy wheels are supplied in an eye-catching Panther Black finish. The same colour is adopted for the side steps, rear bumper and special Fx4 tubular sports bar located in the load bay.
The Ranger Fx4 is exclusively available in four colour choices: Frozen White, Moondust Silver, Sea Grey and Panther Black.
The Fx4 features the latest-generation SYNC®3 with Navigation infotainment system.
All models come with the option of Ford Protect, including a three-year/100 000km standard warranty and five-year/100 000km service plan.
The limited-edition Ranger Fx4 is only available on 4×4 derivatives and can be ordered with the six-speed manual or automatic transmission options.


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Check out the preview of I Don't Get It, the third hardcover collection of Shannon Wheeler's cartoons the follow-up to 2012′s I Told You So and 2011 Eisner Award Winner for best humor publication I Thought You Would Be Funnier.
- Story & art: Shannon Wheeler
- Cover: Shannon Wheeler
- Format: 116 pages, black & white, hardcover
- List price: $17.99
- Sale date: 22 January 2014
- Publisher's description: This next collection of illustrations from cartoonist Shannon Wheeler continues a run that began with the Eisner Award-winning book, I THOUGHT YOU WOULD BE FUNNIER. Where do cartoons go when they've been bounced by the New Yorker? When they're as funny as what's floating in Wheeler's brain, they're boiled down to the best of the bounced and presented in one laugh-out-loud volume.

subset: commoncrawl


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Mechan Controls Plc are a British designer and manufacturer of non contact safety switches for machine guards. Mechan produced its first electronic safety switch in 1972, since which time, it has developed an enviable reputation as the industry leader. Today, tens of thousands of applications worldwide attest to the outstanding reliability of Mechan safety switch and safety interlock systems.
Mechan Controls is now a group of engineering companies designing and manufacturing bespoke products from specialist markets. Originally quoted in 2004 on the PLUS/OFEX London stock exchange, Mechan is now quoted on the ICAP securities & derivatives exchange.
CODEX Switch Monitoring Systems
CODEX is a multi-gate safety switch monitoring system. Easy to install and expand, it can be used to monitor up to 30 gates with one control unit.
F-SERIES DIN RAIL Safety System
The DIN rail mounting safety control unit can monitor up to 30 Mechan safety switches and/or emergency stop buttons in one system. The electronic non-contact safety switches are fully encapsulated, easy to install and tolerant to misalignment.
ISIS Tamper-Proof Safety System
The ISIS safety system is a tamper resistant non-contact safety switch system, suitable for use in most types of machine guarding applications where guard locking is not required.
MAGNASAFE Safety Switches
The Mechan Magnasafe switches are magnetically operated safety switches. Easy to install and maintain, the Magnasafe switches are fully encapsulated non-contact switches ideal for long term for use in harsh / wet environments.
MPX Control Units
Mechan safety control units have been monitoring 1000's of Mechan electronic safety switches of over 40 years. Proving to be safe, reliable and easy to install, the MPX range is a cost effective way to continuously monitor all your safety switches.
S-SERIES Standalone Safety Switches
The S-Type are electronically operated safety switches. Based on Mechan's unique frequency operated switching system the S-Type safety switches provide a more secure, standalone, non-contact safety switch. The precise switching ensures reliable operation and indication on the switch makes identification of guard status easy for the operator.


text: HOME DAMAGE RESTORATION SERVICES [av_slideshow_accordion slide_type='image-based' link='category' items='5′ offset='0′ size='featured' title='active' autoplay='true' interval='5′] [av_slide_accordion id='85' title='Sewer Damage?' link='page,26′ link_target="][/av_slide_accordion] [av_slide_accordion id='67' title='Flood Damage?' link='page,39′ link_target="][/av_slide_accordion] [av_slide_accordion id='93' title='Water Damage?' link='page,22′ link_target="][/av_slide_accordion] [av_slide_accordion id='68' title='Fire Damage?' link='page,24′ link_target="][/av_slide_accordion] [av_slide_accordion id='81' title='Smoke Damage?' link='page,41′ link_target="][/av_slide_accordion] [av_slide_accordion id='92' title='Storm Damage?' link='page,28′ link_target="][/av_slide_accordion] [/av_slideshow_accordion] Knoxville Home Damage Restoration Services All it takes is a couple of minutes for your floors, walls, and furniture to be damaged from water whether as a result of weather or from unavoidable home accidents. Even having a fire start on your property is an event that is completely unpredictable but as a home owner, we are faced with the possibility of these issues happening at any time. Making sure that you are sufficiently prepared in the event of such damage is essential to restoring your home and giving your family peace of mind. Storm Damage Restoration Storms and flash floods are two common issues that home owners across the United States deal with throughout the year. The damage that they bring with them is unpredictable and even if you take the time to prepare for flooding, you never really know how it's going to affect your home. Our team specializes in Knoxville home damage restoration and is here to make sure that you have professionals at your disposal to protect your home from further damage. The equipment that we use is state of the art and helps us to get the job done quickly and efficiently. Water Damage Restoration When water enters the home it doesn't take a lot of time for it to be soaked into the carpet, floors, baseboards, ceiling, or even the walls. Your personal property is also at risk in the event of flooding or a leak. You would be surprised at the amount of damage that your house could experience from a small amount of water making its way to areas that it shouldn't be in. This is where a Knoxville home damage restoration specialist comes in as our skilled restoration technicians will help to assess current damage, eradicate any traces of water, and protect your investment to ensure that you don't have to replace your furniture or any elements of your home. Fire Damage Restoration Fire damage is one of the most unfortunate and common issues that home owners face. With our years of experience we are able to work with your insurance company and an adjuster to make sure that you file a claim that accurately describes the amount of damage done to your home in the event of a fire. We will also be able to make sure that your entire house is returned to its original condition so there aren't any remaining odors or traces of soot and ash. This is essential for making your home a comfortable and safe haven for your family once again. QUICK LINKS Knoxville Water Damage Restoration Knoxville Fire Damage Restoration Knoxville Smoke Damage Restoration Knoxville Flood Damage Restoration Knoxville Sewer Damage Restoration Knoxville Storm Damage Restoration Knoxville Property Damage Restoration Archive July 2016 June 2016 May 2016 February 2016 January 2016 Scroll to top


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Using Jaga's low mass, low water content Low-H2O heat exchanger combined with Dynamic Boost Effect (DBE) technology, the Knockonwood Freestanding DBE is perfect for use with low temperature heating systems. Where there is little wall space or large expanses of glazing, these freestanding heaters are practical and convenient. The elegant wood finish provides an aesthetically pleasing feature, inspired by its eco-friendly performance characteristics.
Please complete the form below to ask us about any of our products or their applications and one of our consultants will be in touch with you.


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Still in Dalat I woke up and read my mum's post about a solar eclipse at that exact moment, in a band of Asia we were in! So out I rushed to see it for myself, not with the naked eye of course but using careful aiming through a camera.
Then we jumped on a bus to Nha Trang, what we thought would be a wonderful beach stop on our tour of Vietnam. We were slightly wrong. Not that it is a particularly horrible place or anything.
Disappointingly the Vinpark, the local water park that is, was closed. Ever since I saw a spectacular advert for an airborne water slide in Koh Panyang I was hoping for a water park day. Denied. Again. Kelly couldn't be bothered with any of that culture junk here, so lazy beaching was primarily the schedule.
We searched for a beach with a pool bar that we'd heard about. The entrance of which was a bit worn down and had a big ferris wheel, that gave it a kind of abandoned Soviet fair ground look I'd seen in Call of Duty games. First impressions aside we booked a luxury sun bed for next to nothing and set about enjoying the relaxation ahead. I swam the entire length of the circular pool and gorged on cocktails and sun.
We then wandered down the beach to find a bar, but along the way heard a familiar sound as the 'Circle of life' music burst into song. The Lion King was playing on the beach cinema for kids. We smiled at each other knowingly and turned to sit down and watch, before the chorus proclaimed "so dnya my prikhodim na planete" – the opening line of the song – in Russian. Yes you read that right, maybe not the actual Russian words, that's Google Translate, but yes Nha Trang is a Russian playground. At the next bar, like all others, the menu is presented in Russian, before we ask for English.
Dinner that evening was at a restaurant called Lanterns. It was very popular so be warned if you go, it involves queuing. Our friend Rimmer recommended it, and it didn't disappoint as the food was very good.
Kelly woke up the next day feeling ill unfortunately, which could've been down to anything she'd consumed in the previous 24 hours, and fixed her to within 10 steps from a toilet. That evening we needed to catch our first overnight bus to Hoi An. Which lets face it, in her state was never going to happen. So we booked a plane. Which was super cheap and allowed her to recover.
That day therefore, we stayed in. I popped out for supplies (basically tissues and the all important Pringles). Whilst on a mission I found some Durian to try. Durian, if you don't know is a large fruit, that has the consistency like it's been melted in the sun. It also smells like that too. In many major Asian cities, Durian is banned from public transport because of the smell. Like rotting flesh, it has a sharp unpleasant smell most Westerners cannot get over enough to enjoy the wonderful taste, I was told.
So I dived in, buying four segments for less than a pound and sat in a park and ate. Tentatively I took my first bit and was surprised it didn't taste awful. Actually quite nice – not amazing as I had been led to believe – but good. My pack of segments didn't have a particularly bad smell, still something present, but not pungent enough to put me off. So maybe I had a bearable batch. Satisfied I returned to my sick wife and watched some movies during our first duvet day in some months.
By the time we needed to get the plane, thankfully Kelly was feeling fine. The double flight back to Saigon followed by Danang, and subsequent taxi ride took us from 11PM until 7AM. So it was a bit of a blur, and thoroughly knackering.
Our hotel is thankfully located in the centre of Hoi An, just outside the walls of the old city. After a brief nap we got up and walked down the road, past countless tailors, dress makers and the like. Each and every rep, outside claiming the cheapest but best quality of course. Our hotel had recommended a particular tailors and Trip Advisor backed this up with glowing reviews.
Firstly, tired bodies needed filling up and we wandered down the very pretty riverside street looking for a preferable joint. We happened to stumble into Morning Glory a restaurant actually thought to be the best in town. Accidentally too at the perfect time, as every other time we passed afterwards we saw what looked like 45 minutes of queue. The two most famous dishes in Hoi An are the sumptuous White Rose Dumplings and Cau Lau. Both of which make us declare it the best food in Vietnam, or at least ten times better than our previous food here. Not that any was bad.
Going back to the recommended tailors it was called Bebes. Inside we were welcomed by Anna our assistant who took us through the process in a very laid back and friendly manner. We could choose the style, fabric, quality and adjustments of any garment and within 24 hours they would be finished. Plus it was less expensive to have a fully measured, tailored suit here than off the shelf in the UK. I indulged in suits and shirts whilst Kelly looked gorgeous in her fitted dresses.
Whilst we got Measured up all of the shop girls were giggling and flitting around, giving us colour and fabric options. It was fun and good to get to know them all, about their lives, children and families. Afterwards we walked around the market streets at night with all their lanterns and wonderful shops.
In the morning we tasted our second bike tour experience. This time around the surrounding countryside. Our guide offered extra stops so we started off at a Pagoda, where he explained the different Buddhas. Then we cycled to a vegetable garden owned by an awesome old couple who were 92 and 85 years strong. They still tend their crops, and took it upon themselves to teach me how to water the plants.
Using a shoulder supported beam, suspending a watering can at each end I needed to fill and sprinkle the water evenly across the crops. It was heavy and cumbersome, so the man nearly 3 times my age showed me with considerable ease how it should be done. Only to then hobble back over, reminding me of his age once the task was complete.
At a next stop we made some pots at a pottery village. On a spinning pottery table I attempted to replicate the spice pot, Kelly nailing hers with aplomb.
At a spectacular carpentry village we bought some chopsticks, before watching a boat being made from scratch, the true service the village offered. Every village we note, has an industry and everybody chips in.
Cycling past a field we spot a buffalo and our guide asks if we would like to ride it. I did and during this random event I contemplated how every day is different and it will be weird to return home to have a routine. Kelly and I are always catching ourselves thinking 'I didn't know I would be doing this when I got up today". I asked the buffalos name, so the guide and farmer exchange confused words which I interpret as "it's a buffalo it hasn't got a name", "but he asked for a name", "tell him buffalo" in Vietnamese, "OK", "Mr Andrew it's called Bingh". The farmer's face looked like he was just thinking, why does this man want to ride my buffalo. Weirdo.
Back to Hoi An and we wander to the Japanese covered bridge, then to other side of bridge during the setting up of night market and the world food fair. It's a busy market with lots of people smiling at us, going about their evening.
For dinner we ate in a French restaurant by the river. Again great food. Hoi An was such a beautiful old city, with such rich history, and exceptional food. This was an unexpected high following on from a bit of a dampener at Nha Trang. Love rekindled it was time to head up the coast, eventually reaching the capital Hanoi, where we were told life was a lot less relaxed and more in keeping with party ethics.


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Starfall - letters, letter sounds, word families, learning games
ABCYA - reading, math, science, social studies, art, etc. GREAT site!
EPIC Books - books that your child can read or listen to someone read to them! Sign up with your email address.
Cool Math Games - more math games that are fun.
Fun Brain - fun games for learning
PBS Kids - all sorts of learning games, videos, activities
Go Noodle - exercise through dancing, yoga, olympic games, silly songs, etc.


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Enabling our client to understand existing process control networks while assisting with security and development phases to leverage future technologies.
The client engaged WorleyParsons to provide security assurance and enable compliance with the latest client and industry standards. The goal for the client was to understand the first steps to OT business integration and put in place plans to safely and securely bridge the OT/IT gap. This client is recognized as an early mover in the IT/OT space and has well developed standards and frameworks that local sites are mandated to follow. The rapid uptake of new technologies and inconsistent OT industry documentation meant the biggest challenge facing them was the lack of understanding existing networks in the OT space.
The client had engaged numerous IT based companies to solve this challenge for them, but they struggled to understand the control system and operational requirements of a modern hydrocarbons facility and lacked the training and ability to connect with key stakeholders. In some instances these IT companies were asked not to return to their the client's facilities.
The first steps in IT/OT understanding is identifying and building relationships with key stakeholders in both domains. Once this is achieved, we utilize the WorleyParsons developed 'Three Step Process to OT/IT Security and Integration'.
Key features:
- Minimum disruption
The discovery phase can be completed on a live plant. We completed mapping and reports for six sites including two offshore platforms.
- Error reduction
Implementing cyber security in the OT space is relatively simple once the discovery phase is complete.
- Benchmarked performance
Standard network documentation has been developed in line with global IT standards.
- No lost time
Management of change can take effect immediately post discovery phase.
- Clear documentation
Documentation takes into account differences between IT & OT, such as static assigning of IP addresses.
- Assisting contract negotiation and future work scope
Documentation produced early on enables clients to explore frame services agreements with IT companies.
The Advisian Digital approach to assisting the client was as follows:
- Discovery
Applying a unique mapping process, developed in house, to map and document existing OT networks. This process can, and has, been completed on a live plant with no upsets. This phase includes gap analysis reporting, which prioritizes areas of concern and remediation steps.
- Remediation
Using the findings and CAD drawings generated in the discovery phase to organize the network as per recommendations and as-build all documentation. This provides ongoing assurance and sets up a framework for management of change.
- Maintenance
Assisting with future projects and helping the client set up frame services agreements with local IT based companies, allowing them to work with WorleyParsons to provide asset management and disaster recovery plans, as well as day to day system hardening and general support.


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In all the hustle and bustle of continual excursions and weekend trips, it was easy to forget how magical it was just to explore Oxford. Some of my most pleasant memories of the program are not from Stonehenge or studio tours but from local excursions and just walking around town. When the weather is nice (which isn't always), Oxford has a safe, dreamy quality, making it more like a rural English town and less like the bustling tourist destination it usually is.
Our first taste of this came in an event mentioned earlier, when we walked through the Botanic Gardens on Alice's Day in the first week of class. While the gardens were peaceful, this was not the full Oxford experience; dreary skies and crowds from the holiday celebrations dampened the pastoral charm of the gardens. However, the greenery was infectuously cheerful and helped brighten spirits even in the rain.
Another note about the Gardens: I returned once more with family to try to find Lyra's Bench (a real monument made famous in Phillip Pullman's The Amber Spyglass). While we were signing in, a crash echoed through the visitor's center. We learned while rushing into the Gardens proper that the old Black Pine, famous as J.R.R. Tolkien's favorite tree, had partially fallen down and crushed a wall. The tree, once a centerpiece of sorts for the Garden, soon will be cut down for safety concerns. It was a quite shocking turn of events, considering our program had visited the tree for the purposes of literary tourism just weeks before.
Other visits in the town of Oxford were a bit brighter. Among our last few excursions was a serene tour of of Magdalen College (where C.S. Lewis taught) and its vast grounds. Magdalen, one of the oldest and most spectacular colleges, contains many of Oxford's photogenic buildings and boasts a large deer park with a walking trail. Other highlights included an ornate, functioning chapel and a casual riverside cafe.
Several days after Magdalen College, the students returned to that neck of the woods for the end-of-program activity: punting on the Isis. The afternoon became a test of creativity in what we could do with a boat, a pole, and two hours. (The answer: haphazard laps around an island punctuated with collisions with the banks and other boats.) The event was a fitting conclusion to the program because our course material started (in spirit) over a hundred years earlier with another boat ride, when Charles Lewis Dodgson went on a river picnic with the real-life Alice and her family.
What we learned: while certain monuments and museums are impressive and educational, and tourist attractions are tempting by nature, some of the best moments of visiting a foreign country can actually come from enjoying small-town scenes and activities. Oxford, as an internationally recognized university town, may not quite reach the level of tranquil fun that a true rural town could provide. However, the times where the city appeared closest to that pastoral ideal — when touring parks and gardens, and later floating on a river, for example — were some of the best times we had in the Program. After seeing so much in a few short weeks, in the end the little things stood out.
Stay tuned for more, including writing samples from our final project.


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Different style components in workplace couches: A broad array of office sofas are now readily available in the market that vary in their dimensions, shades, fabrics and also forms. Experienced furniture designers and also musicians are used by the couch producers of today. Lots of companies likewise supply their customers to get for customized couch styles which allow them to be more imaginative.
When it comes to the velvet chesterfield sofa, there are several benefits of them. Sometimes, people additionally find it challenging to preserve the natural leather couches. Normally, if you desire to come out of the box as well as yet are looking to protect the beauty of the couch, the velour chesterfields are an excellent choice.
Possibly your couch is broken or maybe it is time for a new look, in any case picking out a new couch can be hard for many individuals. Many people do unknown where to begin looking or just what to try to find when acquiring a couch collection. It is rather easy to find your ideal couch set for your office or home with a little study. Keep reading for more details on what you should try to find in a sofa.


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How To Check The Reliability Of Online Shops
Fashion has taken today's youth by surprise, and the availability of numerous options just leaves them spoilt of choice. Sales, deals or coupons: Many online stores have sales on items you might need, and these sales often rotate seasonally or by department. There are so many great products available for Womens online shopping at very low price. In case you want a quick look at our picks, here are ValuePenguin's best shopping rewards credit cards for 2017.
Today, the department store is a national favourite, offering quality goods to shoppers at over 240 stores across 27 countries. Showpo is a trend-focused boutique with a curated offering fun, fashion items for women sizes 4-18. Fragrances, perfumes, and body products are all available online at terrific prices.
MSE is a massive site giving you tips and tricks to cut your shopping costs, and that includes special deals on big brand items. Value: Nearly every item, supply or service can be found online at many distinct price points. Talk about anything and everything in our community discussion forums Ask fellow Shopify users how to choose the best website template, select a payment gateway, design a marketing strategy or set up SEO for your online store.
A top pick for fashion-savvy shoppers around the world, British-based ASOS is one of our favourite online shopping destinations. Banana Republic's top priority is developing relationships with sites that are a good fit for the brand with a strong fashion angle.
We've been running the snazzy Christmas Deals Predictor for the past two years to help you plan for pre-Christmas sales. More than just your average online retailer, Look Bible sells not only designs from the most exciting new brands but also showcases multimedia content to go along with it including a magazine, blogs and an industry-networking hub.


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| Amonet
South Africa's online retail store
| Aramex
Aramex, the disruptive leader in the global logistics and transportation industry.
| Sportal
Sportal delivers turnkey, cutting-edge e-commerce, website & rights management solutions that drive business for sports brands, sponsors & rights holders.
All rights reserved. Copyright © 2019. Republish permission. ADSL & Web hosting proudly provided by Afrihost. Bizcommunity.com, its sponsors, contributors and advertisers disclaim all liability for any loss, damage, injury or expense that might arise from the use of, or reliance upon, the services contained herein. Privacy policy, Terms of Use, PAIA.


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Studio L3's challenge. However, I am late in posting.
I put a piece of red cardstock behind the fan so it can be seen in the scan. I decided to use my grunge as my title "Paris". The images are of things that remind me of Paris- the Eiffel Tower, foreign postage and a fashion shoe. I also attached a "key" to the city. A little lace and a triple-layered flower was added to dress up the fan.
Sunday, September 26, 2010
Alcohol Ink Agate
Posted by Vicki Romaine at 9:33 PM
Labels: Compendium of Curiosities, Fan, Grunge
2 comments:
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About Us
All UD trucks are manufactured to the highest standard in its factory in Japan.
Our New Quon range, launched in 2017, includes features that redefine the Japanese truck market and ultimately keep you on the road longer, like bigger payloads, better safety, smarter fuel efficiency and respect for the environment, and improved driver comfort. We also have a well-established Medium Duty Condor range.
At UD Trucks we are committed to the concept of a 'customer for life' with a Total Offer approach to aftersales that includes extended warranties, service agreements and roadside assistance. All this is offered by our service-minded dealer network, which, as part of Volvo Group Australia, is the largest in Australia and New Zealand.


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"To sing is to pray twice."–St. Augustine
Our parish has a teen choir, a Hispanic Mass choir, an adult choir, & a handbell choir. These choirs serve at Sunday Masses, Christmas Masses, and other special events throughout the year.
Practices schedule is as follows:
If you are interested in joining one of our choirs, please contact Pam Haynes, our director: 731.668.2596 or firstname.lastname@example.com.
If you don't feel called to join the choir, please join us in singing our hymns & Mass parts from the pews!


text: By the way if you havent seen them Mr ley has a cd with maps on it they are evry well done. I took mine to a frinds office that is a profeshinal enger and survyer and we cahnged the fiels from waht they were to austo cad files then printed them out on a lotter. any printer pritns them out but if you have acess to a plotter especly a real expisve one deigned for making maps they are evry sharp in color. We were also abel to print them out on water proof paper. Course it is lot sof maps we put to on a apge and I belive montana alone was soem like 45 maps maby more I never counted Jonathan Ley wrote: >Before everyone else bails from the list... good luck to all in 2003! The >CDT is an amazing thing, I hope it brings you half the joy it's brought me. >May the snow melt quickly, the fires not sprout, the water run clear, the = winter be late, the lightning not strike, the bears be kind, the mail arriv= e, the gear not break, the body endure, and the mind & soul flourish! > >-Jonathan >_______________________________________________ >CDT-L mailing list >email@example.com >http://mailman.backcountry.net/mailman/listinfo/cdt-l > > >


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Get 15% OFF Your Next Order
The best deals come to your inbox. Sign up for GEMPLER'S emails to get exclusive offers and first dibs on hot new products!
Steel Trowel with handy engraved depth markings up to 5-1/2"
Ideal for planting, weeding, smoothing and moving soil. Blade: 7"L x 3-1/2"W. Overall: 15-1/4"L .
Need more options? Check out our full selection of Shovels, Spades and Long-Handled Garden Tools


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Back to the basics. Back to the drawing board. Back to discovering God's plan, God's vision, mission, purpose etc. for this mission in Westwood. I've been reading like crazy, devouring texts and books like a parched man would water. Here are some raw notes from an article I looked at over the weekend. It's just the first article in a series.
The church must be orthodoxological, logocentric, and pneumadynamic.
1. Doxological: Oriented to the Glory of God
The church is doxological, or oriented to the glory of God. Specifically, the church is to be orthodoxological, or oriented to the proper (Gr. ortho) glory (Gr. doxa) of God.
2. Logocentric: Focused on the Word
The church is logocentric, or focused on the logos, the Word, understood in two senses to refer to Jesus Christ, the incarnate Word of God, and Scripture, the inspired Word of God.
3. Pneumadynamic: Empowered by the Spirit
The church is pneumadynamic, or created, gathered, gifted, and empowered by the Holy Spirit.
For further reading and understanding, visit "Missional Ecclesiology: The Trinitarian Church" on the Resurgence website.


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Chapter 1: Leaving The Farm
Chapter 2: Bumpy Ride Home
Chapter 3: Home Not So Sweet Home
Chapter 4: A New Face
Chapter 5: Sweet, Sweet Revenge!
Chapter 6: A Better Looking Face...
Chapter 7: The Great Escape
Chapter 8: Found! & Yucky Kisses!
Chapter 9: Carving Time!!!!
Chapter 10: It's Not So Bad to be Not So Great!


text: Community ECO Store Business Name: Community ECO Store Business Genre: Gift Shops, Retail Shops Long Business Description: Sustainable Living and Resource Saving Products for Home, Garden, Camp, and beyond. Solar Alternative Energy, on and off Grid. Follow us: Facebook | Instagram Business Website Address: http://www.communityecostore.com Business Phone Number: 610-935-2600 Business Address: 252 Bridge St. Phoenixville PA ZIP Code: 19460 Send Message to listing owner Listing Title: Community ECO Store Your Name Your Email Message


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UN condemns Peshawar attacks
UN Secretary General Ban Ki-moon condemned in a statement the attack on a Shia mosque in Peshawar in Pakistan during Friday prayers, which has reportedly killed at least 19 people and injured dozens.
The attack killed Naveed Abbas, a Pakistan national working with the UN Department of Safety and Security, Ban's press office said in a statement Friday.
The statement noted that the attack came merely two weeks after more than 60 people were killed in another attack on a Shia mosque in Shikarpur in southern Pakistan.
Ban, it added, is deeply dismayed by such repeated targeting of innocent people on account of their religious beliefs and in their places of worship. There is no justification for such crimes, he said.
Ban called on the Pakistani authorities to bring swiftly to justice the perpetrators, and urged them to redouble their efforts to protect religious and ethnic minorities and to combat terrorism in all its forms.
The UN official extended his heartfelt condolences to the families of the victims and to the Government and people of Pakistan.


text: There's countless ways to share content and collaborate on projects with friends and coworkers who are located far away. But what about with a group of people all in the same room? There might be a big TV, a video projector and ten mobile devices present, and still people are usually left scratching their heads. A Denver-based startup, Mersive, launched a product today to simplify this interaction, and make higher-quality displays easier to access.


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Living Hotel Life
When going on holiday, many are wowed by the decoration within the room, whether it be the interior design, the views, the comfort or anything else. The room feels like a sanctuary, and even though you may miss home, a tiny, minuscule part of you doesn't want to leave.
The idea of having a hotel room as a bedroom may seem strange for many. Some many think, why would I want my bedroom to look anything like a hotel room, some may think, I will never be able to maintain such a room due to the members in my family (namely the children). However, there are so many touches that can be added to the room to make it feel more personal or example: family photos or furniture, favourite colours, your children or grandchildren's drawings.
Incorporating all of these things into your home will make it all the more special. You'll have your own sanctuary in the home without having to go anywhere. All the furniture, whether it be beds, bedside tables, wardrobes and many more, you can find them all here at: https://inadamfurniture.co.uk/


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Mr. Toads Wild RideMay 25th, 2006
This week has been like "Mr. Toads Wild Ride" at Disneyland…..you never know what's around the corner; so fare (and I hope this is the end of it) I've had the pleasure of a flat tire and a dead battery !
The flat tire happened Tuesday while parked in the BJC garage. While on the phone with AAA, two knights in shining armor came to my rescue and offered to change it for me. I was so touched I started to tear up. You see, I had been at the hospital since 6 a.m. with my mom who was having surgery on her hands. I said to the AAA man on the phone, "Wow, now that's fast service!" So these two gentlemen changed my tire, while their father was having surgery. I was truly touched by their kind heart and quick hands. I feel horrible because I didn't even get their names. I did give them a gift certificate for a free family portrait session. So with a flash and a bang I was off to photograph a private event.
Wednesday morning I went to have the tire repaired and the attendant asked me which tire needs to be fixed. I really wasn't sure what (or why) he was asking and my immediate reply was "the flat one in my trunk". $26 later I'm up and going again.
Today I took my mom back to the doctor to have the dressing removed and her hand checked. All is well and the healing process is progressing nicely. This evening I stopped at Sam's to pick up a few office products, but when I went back to my car it wouldn't start. I mean nothing! No clicking, no buzzers, ding ding ding, NOTHING! So out comes my trustee AAA card again. This time they actually had to send out a truck to help me out. My new knight in shinning armor arrives! It's Terrance from Harsley's Towing and he goes right to work.
I have to tell you, he looked at me a little strangely when I all of a sudden pop out my pocket camera and start taking snaps. I explained, it's ok, I'm a professional, no really I am, this is just my toy camera – really!
Thanks Terrance for all your help! (It was a dead battery as we thought, not the alternator.)


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May 23, 2005
Just a small update today, I added a link
for guitar tabs for the song Italian Leather Sofa by Cake, which is the
opening theme song for Mission Hill. Too bad I don't play guitar.
March 7, 2005
Another episode capsule is up, this
time for "THE BIG-ASS VIACOM LAWSUIT" ( Or, "Andy vs. The Real
February 16, 2005
I've added a link to the Mission Hill and Clone High Refuge, a fansite for both Mission Hill and another very funny cartoon called Clone High. What's interesting is that the person behind the site is working on animating new episodes of both series in Flash. They're not ready just yet, but take a look.
I've also added the episode capsule for "Kevin's Problem" (aka: Porno for Pyro). Remember, for any of the episode capsules please feel free to contribute anything I might have missed. Just contact me with the 'Like My Site?' button on the left side of every page.
Oh, and make sure you look just below for the big news in case
you haven't read it already.
January 15, 2005
The news we have all been waiting for is finally here. I've heard from a reliable source that Mission Hill is finally coming, to DVD! They are scheduled to be produced by June, and be in the stores in November. Extras are still being discussed, but expect things like commentaries and info about the lost episodes.
Thanks to everyone who helped out with the DVD campaign, I'm not
sure if Warner Bros. decided on a DVD because of our letters, or due to other reasons,
but our efforts certainly didn't hurt, and in the end, we are getting what we
all wanted.
October 22, 2004
Some great news for those of you who miss Mission Hill. TBS will be showing it starting December 4, 2004 as part of it's 'Too Funny To Sleep' programming block. You can find more info about the block here and the scheduling here.
Also, I've uploaded the second episode capsule, for the episode "GREAT SEXPECTATIONS" (Or, "Andy Joins the PTA").
The first epsiode capsule is
up, appropriately for the first episode, "THE DOUCHEBAG ASPECT" (Or,
"Pilot Episode"). Read it to find out just about everything
about the episode, including jokes you may have missed. It's very possible
I missed something, so please if you have any additions contact me with the
feedback link on the left side of every page. And stay tuned there's more
on the way!
July 31, 2004
This is sort of Mission Hill-related, as it relates to Brian Posehn (the voice of Jim) doing a comic book, which is what Mission Hill was inspired by. Okay a bit of a stretch but whatever.
This was taken from Newsarama.
July 12, 2004
I've FINALLY gotten around to adding a new image to the Multimedia section. It's a picture of Andy's unflattering caricature of a man from the episode "BROTHER'S BIG BONER" (Or, "Unemployment Part One"). So check out the new image here. And be sure to keep visiting because there will be much more very soon!
While not exactly Mission Hill related, Gamespot has an article about voice acting in games, which features Scott Menville, the voice of Kevin French. Check it out, it's an interesting read.
Read the full article here.
May 18, 2004
Mission Hill is returning to Adult Swim! According to the official site, starting Sunday, May 23 you can see Mission Hill at 1 am and 4 am every Sunday. These times are Eastern and Pacific, so check your local listings and be sure to tell your friends! The show had very high ratings the last time the episodes were played so Warner Bros. is paying attention! This is probably the simplest thing you can do to get those DVDs made!
In site news, there are a few minor updates. Did some modifications to the FAQ, removed a dead link from the Links page and added a new video clip in the Video section, from the episode "HOT FOR WEIRDIE" (Or, "Kevin Finds Love").


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Yamaha's Whitetail Diaries
Yamaha Takes Over Deer Camp
We head to the annual Yamaha Whitetail Diaries media camp where several writers will be joining up with the Yamaha staff and Whitetail Diaries' host Wade Middleton for a week of field testing, hunting, and product evaluations on a wide range of hunting related items. During this year's event, we'll be joined by Archery Talks' Lucas Cooney, outdoor writer Spencer Neuharth and Conner McKibbin of American Hunter Magazine.
Please note that only previews for this show will be available online at this time.
Showtimes: Tuesday - 11:00 am, Wednesday - 10:00 pm, Friday - 11:30 am, Sunday - 3:00 am


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LJ-SEC: (ORIGINALLY POSTED BY navytron89)
After reading the article here I'm completely pissed off that Senator Barack Obama would even go to the mega-church of Saddleback Community Church. The church in the past has missonary groups go to Africa and spread "the word of Christ" and tell those who had AIDS, they got it do to their failure to worship Jesus/God.
While I do believe the Senator is a good person overall and his mission to improve AIDS awareness is a very laudable goal its the fact he went to the door of the enemy with the idea of changing their little pea-brains about AIDS.
I think it was inapproprate for him to even go to a chruch, the whole point is seperation of church and state, not have the politicians in the pulpit to begin with. It was bad enough when Pat Robertson tried to run and now here we are on the opposite end of the spectrum.
I remember awhile back (2002-03) when Warren was attending a Christian/Fundy Summitt in D.C. and Pat Robertson or one of his asshat associates said that AIDS in Africa was none of our concern. Instead we should cut their help funding and spend it on more practical things like the Ten Commandments in the classroom. I remember that Warren agreed with that opinion during interview on national TV.
Its make me concerned that either the Senator is trying to sway the enemy to be more compassionate or that the enemy is slowly corrupting him.
While it was a nice bit about all those Fundies fuming at his appearance at the event and even boycotting it. I find that once again its the most rabid, hardcore wackjobs speaking from their buttocks to make another pointless opinion heard about fetus rights that they stop caring about after the baby is born and "gay" marriage is bad.
Hopefully by showing compassion the Senator will change the fundies minds to be more tolerant; but even so I think he may have maligned his voting base by even going there.
On the other hand; Rev. Rob Schenck, who heads the National Clergy Council; proves just how big of an asshat fundy he can be by all those statement he made on the first and second pages of the story. It amazes me that he only opens his mouth to change feet and its amazing that he can't fit both of them in there at the same time.
One last thought is why is Warren suddenly concerned with AIDS?
I'm guessing a family member or close friend must have it or HIV as that was the only way I'd ever see that jerk be compassionate towards AIDS victims (yes, he one of those whole can give false compassion out by the bucket loads).


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I always end up having over ripe bananas in my kitchen. The easiest way to use them up is to quickly whip up a batch of yummy soft banana muffins. Your healthy breakfast on the go, ready in a jiffy !!!
You will need :
All Purpose flour - 200 gms
Baking Powder- 2 tsp
Baking Soda- 1 tsp
Granulated Sugar- 115 gms
Egg- 1
Ripe Bananas Mashed - 3
Buttermilk- 1 cup
Oil- 2 tbsp
Vanilla Extract- 1 tsp
As always, first thing to do before you start any baking is... Preheat!
Preheat your oven to 190 Degrees C.
Grease a 12 hole muffin pan or line with your favourite fancy cupcake liners.
Sift all the dry ingredients together in a mixing bowl.
In another bowl beat the egg, mashed banana, buttermilk, oil and the vanilla essence.
Make a well in the centre of the dry ingredients and pour the wet ingredients. Mix just until well incorporated. Dont over mix.
Spoon into muffin cups till about 3/4th full. Place a cashewnut in the middle (optional).
Bake for 20 minutes or until a skewer comes out clean.
Take it out of the oven and cool for about 15 minutes in the tin.
Your yummy banana muffins are ready!!!
Savour it with some whipped cream or as it is.


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Playing an eccentric cruciverbalist who falls red boots over umbrella for her blind date, and then travels across the country to convince him he is her true love!
A nice, light way to postpone doing work, together with some laugh out loud moments (well some, I can't believe she's doing that, laugh out loud moments).
|(Image from IMDb)
|(Image from IMDb)


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The human genetic code is an incredible thing, it's a building block that exists in every cell in our bodies, it's fantastically complex. With that in mind, surely it'd be almost impossible to quantify the amount of data it'd take to make a human being?
Not so much. Turns out a human being's entire genetic code take up just 1.5GB. Not bad considering the game Watch Dogs was over 40GB in size.
It's from here that things start to get a little mind-blowing because actually, that 1.5GB counts for just one copy of the code, in fact your body has a copy in every single cell in your body, all 40 trillion of them.
The result of that is a cool 60 zettabytes.
To give you some idea of just how big a number that is, by 2020 all of the digital information in the world will amount to around 40 zettabytes.
Your body contains more data in it than every single line of code in the world, and it'll continue to do so for many years.
How do you get this figure? Well you can thank the science blog Veritasium which used some serious maths to calculate the exact amount in data it'd take to store a human's genetic code.


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LOVE // Jennie + Brandon
Some people have faces that the camera just can't get enough of. And, then by some stroke of luck, those people get married and create the perfect storm of photogenic greatness. Jennie and Brandon, not only are you two SO much fun to be around, but your love for one another is just so wildly palpable. Thank you for exploring downtown Denver with me and for making these photos some of my all-time favorites!
Be sure to check out Jennie's AMAZING blog, Rustic Glory, here. Homegirl has some amazing tidbits on fashion, food and all-things-fabulous!


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Media Release :: 4 August 2016
Ms Emily Lee-Ack, Executive Officer of Women's Health Barwon South West, has been appointed Chair of the Partnership. She will be joined by a diverse and high-calibre team drawn from local industry, including transport, tourism and agriculture, as well as the arts, regional education and the Aboriginal community.
Minister for Regional Development Jaala Pulford congratulated the eight successful applicants who were today appointed as the community and business members of the Partnership. They were chosen for their broad skills and experience, know-how and ability to positively contribute to the development of their communities.
Regional Partnerships are also being established in Barwon, Central Highlands, Gippsland, Goulburn, Loddon Campaspe, Mallee, Ovens Murray and Wimmera Southern Mallee to give rural and regional Victorians greater say about what matters to them and direct regional priorities straight into the heart of Government decision making.
Ms Felicity Melican, Principal of Sinclair Wilson (accountants and business advisors) will be Deputy Chair of the Great South Coast Regional Partnership.
The other members include:
• Ms Lisa Dwyer, dairy farmer and non-executive Director, Dairy Australia and LiveCorp
• Mr David Pope, Operations Manager, Popes Timboon
• Ms Felicity Melican, Principal, Sinclair Wilson (accountants and business advisors)
• Mr Wayne Kayler-Thomson, Chairman, Great Ocean Road Regional Tourism
• Mr John Bell, CEO, Dhauwurd Wurrung Elderly & Community Health Service
• Ms Sarah Schmidt, Director, Hamilton Gallery
The community members will be joined by local council CEOs, Regional Development Australia representatives and senior Victorian government officials.
Boosting tourism opportunities, creating new jobs, supporting local food and fibre and improving education outcomes, are likely to be among the matters addressed by the Great South Coast Regional Partnership.
As Chair of the Great South Coast Regional Partnership, Ms Lee-Ack will also sit on Victoria's Regional Development Advisory Committee, working with the other Partnership Chairs on cross-regional issues and opportunities.Download Media Release


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|STRIPED BLAZER - Loft
WHITE DENIM CAPRIS - Express
NAVY TANK TOP - Old Navy
RED BELT - Thrifted (Thanks, Mom!)
GINGHAM WEDGES - Payless
SUNGLASSES - Fierce left them in my car :)
I decided to wear my striped blazer because, well, I haven't worn it in a while and it was overcast. I originally paired it with light blue rolled up jeans, but later decided it looked better with white capri ones. I also decided to mix prints by pairing the stripes with my new gingham wedges from Payless. Payless was having a BOGO 1/2 off sale so I couldn't help myself and had to buy 2 pairs of wedges. These were the 1/2 off ones and ended up being only $7.50!!!
Obviously I have a shoe obsession. Or addiction. Whatever. There are probably worse things, right? (just nod your head) And while I'm at it I'll leave you with one more pair of shoes I've been scoping out (in case Camouflage wants to give me an "I love you" gift). They're on sale and they look almost identical to the Jeffrey Campbell ones which are almost $100 more! And if you end up buying them too? Let's just try not to wear them at the same place at the same time, deal?


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April 29th, 1:00 PM ET
This webinar will help Head Start users in the search and navigation of the Census website, and in locating specific topical data as it relates to children. We will include visual examples, show you actual tools to locate and access data, and demonstrate how these data can be used.
WebEx access: Access the webinar
Call in: 800-988-9528
Participant passcode: 7519699


text: We've added a "Nick Name" field to the system to help Camps distinguish between campers with the same name, and to allow the parents to let the counselors/cabin leaders know what their child prefers to be called. We've also added some UI enhancements in the parent portal. The processing spinner (which shows during data transactions) will now show in the middle of the page so that parents know something is happening behind the scenes.


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The Future of Work
Work is urban, integrated, and more integral to organizational culture than ever. Image © Connie Zhou
Anniversary milestones are often an ideal time to reflect on where we've been and to position ourselves for the future. As Gensler turns 50, thinking about the workplace seems like a natural way to mark the occasion. Art Gensler started our firm by focusing on interior architectural at a time when "workplace" wasn't even a term. The physical workplace of today, where we spend so many of our waking hours, has evolved and changed dramatically from the ones we've designed over the last 50 years. And the next 50 years may bring even more fascinating changes.Where We've Been
In Gensler's early days, a key driver of corporate workplace design was real estate efficiency. Open plan workstations aimed at reducing square footage were just becoming mainstream. Tall panels around each workstation provided perceived visual and acoustic privacy. Years later, the cartoon "Dilbert" made much fun of these spaces. Space standards were based on employees titles, not their function, and the amount of real estate you were given reflected your position within the organization. As the first generation of personal computers became common in the workplace, designers found that big CRT monitors did not fit on a typical desk, so the corner workstation was introduced. To get electrical power and data cables to each desk, workstations were linked together—the workstations got even larger as a result. Because organizations were often changing, "universal planning" replaced re-configuring space as the common way to move people in the 1980's. This not only saved real estate, but time and cost as well.
By the mid 1990's, technology was driving much of the change that we saw in workplace design. Personal computers got smaller. Flat screens allowed a computer to once again fit on a desk. Panels got shorter or went away entirely to encourage more collaboration and openness between colleagues. As organizations got flatter, space standards becomes fewer and more of a universal size and layout. This was the Age of Flexibility. As equipment size reduced and work became less paper-based and more electronic, the desk size reduced as well. The concept of "benching" was introduced and staff began sitting together at one long table or work surface.
By the late 1990's, laptops and cell phones had dropped in cost and become readily available for both business and personal use. People were no longer tethered to the desk. Wi-Fi gave employees the ability to freely move around the office. This was the Age of Mobility. We measured how our clients were using space and found that people were only at their assigned seat 40-50% of the workday. They were working in conference and team rooms as much as they were working at their desks. Working from home was becoming more prevalent, but internet connections were still slow for big applications and many still preferred to work at the office for speed and access to specialized equipment.Where We are Today
Today, organizations are moving data to the cloud. We are no longer tethered to servers in the office. Smaller devices make it easier to be even more mobile. This is now the Age of Work Anywhere! As Martha Johnson, former GSA Administrator, said "Work is what you do, not where you are." There are numerous drivers of this change including technology, multi-generations, and globalization. But one of the biggest drivers in my mind is that the work people are doing has fundamentally changed.
In our 2008 U.S. and U.K. Workspace Survey research, we uncovered four different work modes universal to all workers: focus, collaboration, learning and socializing. We measured how people work, where they work, and how effectively the workplace supported their efforts. What we found is that work has dramatically shifted, but the workspace has not kept pace. For the most part, the stereotypical work environment most organizations inhabit is no longer effective. And the exciting news? The companies that do have highly effective workspaces rate higher in terms of business performance and innovation measures. Conclusion? Space matters.
We have continued to measure how work is changing and evolving. In 2013, we discovered that workers are spending more time in focus or individual work and less time in collaborative or group work. But those organizations that provide "balanced spaces," which prioritize both focus work and collaborative work equally, outperform those in "unbalanced spaces" on every creative and innovation metric we measured! Clearly, space impacts individual as well as organizational performance. We are learning that we need a variety of work settings to support the varied and personal ways of working. Mobile technologies now easily allow us to move from one effective space to another without interrupting our flow of work. And we need spaces that support this easy shift from individual work requiring focus to group work requiring collaboration.
But it's not just about performance. Space also plays a powerful role as a connector. It can better connect people to people for face-to-face or virtual group work. It can better connect employees to organizations and to their mission. It can better connect people to data. In fact, we already have the technology to sense a person's presence and automatically turn on lights and power, adjust the air temperature, and respond to a user's behavior upon arrival. There are wearable technologies and embedded digital technologies that can connect people, places, and things through cloud computing and big data; these technologies are already finding their way into the built environment. The confluence of these technologies are allowing the physical environment to respond to individuals' behavior and pushing information to occupants in a seamless and personal way. Workplace can now respond to personal workstyles and react to how occupants are actually using the space. The boundary between digital and physical are more blurred than ever.Positioning for the Future
Now that people can work anywhere, the real question becomes how do we create workspaces where people want to be? The answer lies in understanding what people really care about.
First, the work itself really matters. In his book Why We Work and his TED talk of the same name, Barry Schwartz explores what makes work satisfying. He notes that we don't work just for the money, but for the meaning and soulfulness that comes from a job well done. In his book Drive, Dan Pink calls it a feeling of purpose. Mihaly Csikszentmihalyi calls it a state of "flow." I believe it is all these things.
In a world fragmented by digital technologies and boundless streams of sometimes conflicting information, people more than ever seek purpose, meaning, and a strong sense of community with each other from the places they work. Work has become a central marker of selfhood in addition to being a source of gainful employment. Workspaces that engage employees in personal ways and seek to tangibly improve the experience of end users have a much better chance at bringing a sense of personal fulfillment to each and every individual worker. And this sense of fulfillment leads to more satisfied employees, because when the space gives the end user a sense of comfort and ease, that person is better able to focus on the things that make them happy. And that includes their work. It can assist people to find true joy and satisfaction in completing the task at hand and feeling energized at the end of the day.
As we move forward, we must remember that people are individuals with singular tastes, preferences, and goals. There is no one-size-fits-all workspace anymore. In fact, providing one size fits none. Personal customization has become standard operating procedure for everything from mobile phone apps to shopping, and workspace design must embrace this trend. People want autonomy to control when and where to work. That includes workspaces that provide a choice and a variety of work settings—in fact, our research shows that providing choice improves job satisfaction. Workspaces must also be customizable to adapt. We must never forget that the next iteration of change is always on the horizon, and building a level of customization and adaptability can allow workspaces to evolve with the times.
Wellness is another key factor in employee satisfaction. People want to know their organization cares about their individual wellbeing, and providing access to great coffee, healthy food choices, fitness amenities, abundant natural light, and views of outdoor spaces shows workers the level of care they crave. It also keeps workers healthier and that's good for organizations and society in general. What if, in the future, employees left the office at the end of the day actually healthier than they were when they arrived in the morning? Exploring how our corporate campuses, buildings, and workplace can foster healthier habits is an exciting challenge.
This year was a tipping point. At 27 percent, the millennial generation now make up the largest population of the workforce. Millennials have different expectations from their predecessors; they are approaching the sharing economy indifferent ways. These differences are changing the ways we shop and bank, use social media, and work.
But we are discovering that the impact on the physical work environment at the office is not vastly different. What Millennials want, is what we all want: to enjoy purposeful work, to be a part of an exciting and vibrant organizational community, and to be treated as unique individuals who are valued as part of that organization. The potential of the physical work environment to stimulate creativity, new thinking, connections, engagement and expression has never been greater. We must embrace this opportunity and constantly keep our eyes trained on the future.
Janet Pogue McLaurin is a Principal in Gensler's Washington, D.C. office. She co-leads the firm's Workplace Practice and is a frequent writer and speaker on the critical issues affecting the design of high performing work environments. Contact her at firstname.lastname@example.com.


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Lyrics Training was a favourite site for me but for some time I have stopped using it in class. I was thinking to do a fun exercise with a class and my 16 year old daughter said 'Why don't you use Lyrics Training' fot the lesson. I listened to her and visited the site to have a look at the changes and I found out that they are testing the teacher account. I signed up as a teacher , chose a song and created my custom exercise and then sent it to my students.
Speaking For An Audience
These new kids need more public speaking skills than us. They will work on projects in teams, they will present their projects and they will need to be more confident in front of an audience. Thus, as teachers we can encourage our students to speak in front of an audience by assigning weekly projects. Friday afternoons can be a great time for doing this as on the last day of the week they feel tired and demotivated. You can find a lovely box, or a jar and put the project ideas in and ask them to choose the one for the next week.
Here are some suggestions but we can add more,
- Every week students choose a song which tell a story and prepare a 3-minute presentation about the song. They have to mention the band, singer, genre and the story of the song.
- Students scan through the week's newspapers, online news channels and prepare their 3-minute presentation on current affairs.
- Students find out about the movies or the plays on and choose one that they've watched or want to watch and prepare a presentation.
- Students choose a quote that they like. Tell the class who said that and why they have chosen it and what it means.
- Students choose a colour and research how that colour effects people.
- Students choose two places they want to compare. they can be two cities, two cafes, two bookshops, two clothes shops, etc and prepare a 3-minute talk.
Cool Warm-Up Activities and Sites for #ELT Classes
Beginning a lesson with a warm-up activity has many advantages. I can just list some as
- waking up tired students
- breaking the ice
- encouraging students to talk and think on the subject
- allowing students to settle down and prepare for the lesson
- previewing or revising a particular language area
- introducing the topic
- providing humour
- starting the lesson with a smile
- energising your students
- proving oral fluency practice
- and they are easy to prepare
There are many activities that can be used as warm-ups. Course books usually support the teachers with a short activity but from time to time, to surprise the students we can bring drama into the classroom. I'll just list here a few drama activities and a few links for websites in this post.
- Divide the class into two and tell students to stand as 2 lines. Tell them Line 1 will form a circle and that will be the inner one, line 2 will form another circle around the inner circle. Set time limits. Ask students to come face to face and talk about a) something they remember from yesterday b)what they know about the topic you are going to work on. When the time is up, tell outer circle to move until you stop them and inner circle to wait for a new partner. (You can play music while they are moving) When they stop, they can talk on the same topic with their new partners. You can finish the activity after a few rounds.
- The teacher gives a piece of paper to the students and asks them to write at least 5 features of their character. The teacher collects the papers from the students and puts 4 chairs in a + shape. Then the teacher reads the features written on the papers and students who have those features are asked to gather around the same chair. Then the students can talk about their similarities. You can even put them in groups and ask them to create a class poster. This activity will be a great 1st week activity even with large classes.
- Group your students and ask them to freeze frame a few scenes from the previous chapters of the book you have been reading after each scene the rest of the class try to guess which scene is in the frozen frame.
- GoNoodle is a fun website you can find many videos and use them as warmers or energizers when you feel your students are getting bored.
- Famous Movie Segments for Warm-ups and Follow-ups will come handy when you need something different.
Have a great term 🙂
Roald Dahl 100 Years Old
September 13th is the Roald Dahl day and this year it's his 100th birthday. Regular readers know that I'm fond of Roald Dahl stories and I love using them in class. I just wanted to bring some links that you'd like to use with your classes.
Here the schools are not open yet but I'll start the year with some Roald Dahl stories with my Grade 11 and 12 students. So here you can find some ideas and websites which will inspire you with your celebrations.
My number 1 is The Official Roald Dahl Website, full of ideas and inspirations. You can find writing tips, games, stories and teaching materials there.
On Teacher Vision, you can find loads of links with great ideas.
TES also has lesson plans and ideas.
British Council's literature project BritLit has a great lesson on The Landlady with the full story.
Some older posts on my blog can be found here
Well, let the celebrations begin!
A first week activity inspired by a novel
September is here and another school year is on its way. I'm just enjoying the last few lazy days reading and planning ahead. I'm reading "The Little Paris Bookshop" by Nina George at the moment. I loved the book. Not only for the plot, not only it is set in Paris along the River Seine but also the richness of the creative writing ideas that pop up in front of my eyes while reading it.
The book takes place in Paris and tells the story of a bookshop owner Jean Perdu who calls his bookshop the Literary Apothecary, because he doesn't just sell books to his customers, he also prescribes them to suit their minor ailments he diagnoses in them.
I just don't want to forget those brilliant ideas Mr Perdu brought into my mind so I decided to write them.
Here is one as a first week activity. Mr Perdu says "books are like people, and people are like books." And continues " I ask myself is he or she the main character in his or her life?" (pg 28) well, I'm not going to reveal more but I'm planning my first day activity as follows.
The activity will be suitable for any level if you plan it that way but I'll do it with my year 12 students.
Tell students they are a character in a novel.
Tell them to describe themselves, their motives, ambitions, weak points, strengths.
Who else are in their story? What kind of characters are they? A short description for them as the characters of the story…
The blurb of their story, their problem and how they expect the story will end.
I'll tell them to create a book cover and a few pages of their books to display on classroom walls.
I think this will be a good beginning for a class who will be studying hard for their university exam. This year their main concern is the exam and how they will shape their future so I guess starting the year with these book covers will be fun.


text: Am I to understand that South America and Africa hosted a better climate for dinosaurs, when most K-T dinosaur fossils are found in North America? Very little is preserved at the K-T boundary layer, probably an effect of the change in depositional chemistry. What we need is a great fossil dinosaur find [not reworked material] above the K-T layer to show which continent's post-impact environment could support the survivors. Maybe answer a few questions like, why the environmentally delicate amphibians faired better than dinosaurs like ceratopsians and hadrosaurians?


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Racing Roundup
The 28th annual Pennsylvania Sprint Speedweek kicked off Friday night at Williams Grove Speedway where Trey Starks led all 30 laps to score the win. Starks outran Greg Hodnett, Chad Trout, James McFadden and Brock Zearfoss for the $5,000 win.
Speedweek hit Lincoln Speedway Saturday where it was Danny Dietrich winning a nonstop 30-lap thriller that saw Lance Dewease come on strong to challenge on the final circuit. But it was Dietrich scoring the $7,000 win in the Kevin Gobrecht Memorial ahead of Dewease, Brian Montieth, Lucas Wolfe and Chad Trout.
Jeff Rine was the Super Late Model winner Saturday at Port Royal Speedway over Tim Wilson, Dylan Yoder, Tim Smith Jr. and Andy Haus, with McConnellsburg's Marvin Winters placing eighth.
Jeff Halligan was the Port Royal 358 Sprint car winner over Eric Parker, Steve Drevecki, Doug Hammaker and Troy Wagaman Jr., while Zach Newlin won the makeup 305 Sprint car main over Jonathon Jones and Dylan Shatzer. Kyle Smith won the regular 305 Sprint Main over Nick Sweigart and Kyle Ganoe.
Logan Roberson took the win in Saturday's Crate Late Model feature at Hagerstown Speedway over Mike Franklin, Tyler Hershey, Transton Stoner and Tanner Kerr.
Jamie Zentmyer won the Pure Stock feature at Hagerstown over Jamey Swank and Wayne Hawbaker while Jonathon Raley won the Hobby Stocks over Tom Caravello and William Ecton, Jr.
Jason Shultz picked up the 360 Sprint car win Saturday at Selinsgrove Speedway over Derek Locke, Mike Walter, Chad Layton and Mark Smith, while Coleby Frye was the Super Late Model winner over Hayes Mattern, Bryan Bernheisel, Brett Schadel and Jim Yoder.
Pennsylvania Speedweek invaded Path Valley Speedway Sunday night where Ohio driver Cole Duncan stole the big $10,000 payday from the Posse, taking the win over Freddie Rahmer, Brock Zearfoss, Harrisonville's Mike Wagner and Trey Starks. Logan Wagner earned a $500 bonus for the Hard Charger, going 24th to ninth in the 50-lap feature.


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I started my career at Fox Networks Group immediately after I completed my Master's degree.
I am currently working as a Market Research Analyst in the European Research department. Having already spent 6 months on the position, I can take advantage of the numerous opportunities the company offers to us. A major challenge I initially faced was working with abundant data and various regular and ad hoc requests concerning our channels' performance across Europe. Our Bulgarian team constantly collaborates with the rest of its global members all over the world, thus gathering in-depth knowledge and invaluable experience from the international multi-media business environment.
For me, FOX, with its friendly atmosphere and good vibes, offers great thrills combined with exciting opportunities to grow my career just in line with my aspirations.
I work as a Market Research Analyst at the European Research Department of FNG Europe and Africa. I joined 6 months ago, right after I completed my MA degree.
Being part of a European team, my responsibilities are quite challenging. Communication and work assignments are bound with a number of people located in different countries and time zones. This dynamic work environment gives me the feeling that I really am part of multinational company. This incredible, positive and open-minded team gives me the ability to look into the future hoping that at some point, through the professional guidance and high-level support of my colleagues, I will become a bright professional like them.
Being part of the FOX family is one of the best experiences I have ever had.
My professional path at Fox started almost 9 years ago, way back in May 2008, wow! How time flies…
I started at the reception and moved my way up to be Regional Distribution Manager today, directly responsible for Bulgaria, Macedonia and Albania.
The possibility for facing a new challenge every day is what keeps me going. I am proud to say I have not only great talented colleagues but also good friends in many places around the world and I <3 television!
I am a Junior Legal Counsel.
I have been with FNG for 6 years and a half.
I love my job here because I am part of a great team of professionals and at the same time I do something I have always been passionate about.
I love FNG because it gives me the chance to work on many exciting projects for some of the most appreciated TV brands around the world.
I am a Legal Counsel.
I have been with FNG for 3 years.
I love my job here because of the wonderful colleagues, the opportunity to work in a company where you can never be bored, because I never stop learning and improving my skills. I simply enjoy my time at work.
I love FNG because FIC gives me the unique opportunity to be myself.
I am a Quality Control Supervisor.
I have been with FNG since the beginning.
I love my job here because I love what I do... and the people I work with.
I love FNG because we can work hard and still have fun.
I am a Key Account Manager.
I have been with FNG for 2 years.
I love my job here because sales is my passion and it doesn't get better than doing that for a brand such as Fox.
I love FNG because I am part of a successful story of great brands, young and motivated people and an environment which gives me opportunities to learn every day, helping me grow personally and professionally.
I am a Program Coordinator.
I have been with FNG for 4 years and a half.
I love my job here because I love watching series and I get great satisfaction to plan smart and innovative programs.
I love FNG because it is the best TV media I've ever worked at.


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No matter how much you prepare, there will also be a handful of things that you cannot do until you arrive in the UK. Our Touchdown Pack makes getting all of those post-arrival essentials in place super easy and stress free. From your UK Bank Account, to a UK mobile SIM card, to international money transfers and more, we've got all of the important stuff covered for one low add-on cost.
We'll mail your SIM card to you in advance; book your bank appointment before you leave home; and help you every step of the way to get the most out of your Touchdown Pack inclusions!
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A burger + free beer combo card that you can redeem at any Walkabout Pub, anywhere in the UK!
Digital train & tube maps, pre-loaded onto your 4GB USB card. You'll want these to get around when you land!


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A Review on Indoor Data Transmission and Software Application Controlling using Light fidelity
Publication Date : 02/12/2015
Author(s) :
Volume/Issue :
Volume 2
Issue 11
(12 - 2015)
Abstract :
LI-FI is a new wireless technology implemented by the German physicist-Harald Haas in the year 2011. By over coming the drawback of WI-FI we are using LI-FI technology. The main aim of LI-FI is to transmit data using LED bulbs and intensity of light is so fast that it is invisible to human eye. This paper describes to control indoor data transmission to control software. In this paper instead of Radio waves we are using LED bulb as a medium to transmit data which provides better security and also it has higher bandwidth
No. of Downloads :


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With the increase in the length of the working schedule today, people hardly get any time to relax. And, the time people get is most of the time utilized by watching television and listening to music. However, it would be great if both of the two elements of relaxation could be combined together for a better experience. Television, when accompanied with wireless TV speakers, can provide the best of experience. All that one needs to do is to just simply pair the speaker with the television and they are good to go. The television speakers are no less than a home theatre as they can provide the exact sound output from the small sized speakers only. There are wireless speakers for the television which are best for those who want to clip the speaker on a hook or something. Such speaker comes with clipping design which allows easy clipping of the speaker with a simple hook or it can also be at the backside of the television panel. One can also carry it easily wherever they go. It is IPX7 water proof which allows people to carry it when it is raining also. It also comes with 3.5mm audio cable jack and thus allows playing music using the AUX cable also.
Not just small sized wireless TV speakers, but there are also various mid-sized speakers which are known for the monstrous sound it delivers. The hard hitting bass delivered by such speaker does not let the listener feel that they are hearing to music from a small Bluetooth speaker and rather feels like a dolby digital home theatre. Such a speaker comes with massive 20,000 mAh battery which allows the user to connect it with their TV and can play music for three days straight. Also, such speakers come with funky handles which allows the user to carry it easily and can easily create a party type mood anywhere.
If one needs good and crisp sound along with superb bass they can go for the high treble portable TV speakers. Such speakers can connect to up to 3 televisions at the same time and also provides superb sound. The best part is that this speaker is IPX7 water proof which allows the user to play music outside by connecting it to the TV when it is raining also. Such speakers generally come with built-in 6000-7000 mAh of Li-ion battery which can deliver power with music for up to 20 hours. One can even attend calls through it with just the press of a button. Users can also use it by charging from their power bank.
Taking out the relaxation time to a whole new level has been possible with the help of portable TV speakers as they not only connect with the TVs but can also be used with the smartphones. Some of the TV speakers today also come with in-built party lights which sets the mood right and can help people to create a party mood anywhere.


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The school's results were impressive: in a community where every single child spoke English as a second language, pupils were giving long, complex and articulate answers to the questions they were asked in class, and showed a parallel improvement in their written work.
What are these techniques? You can see an example in the video below:
Active Questioning has a lot of the ingredients of really effective CPD: it's specific, it's practical, it's relevant to all teachers and teaching assistants, and it can make an immediate difference in the classroom. If you'd like to find out more, see the pages for Active Questioning Plus and Active Questioning in our catalogue.
Active Questioning is going to be coming to nimbl soon as well, so watch this space.


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Viridian Organic Echinacea Tincture 50ml
Customers who bought this product also bought
Viridian's 100% Organic Echinacea tincture is made with the whole fresh Echinacea purpurea plant. Grown and traditionally harvested and tinctured in Herefordshire and the Welsh borders. Certified organic by the Soil Association - better for the planet, better for you. The MHRA (the government's medicine and healthcare regulatory authority) has recommended that echinacea is not given to children aged under 12. If you'd like further information visit the MHRA website.
Directions for use
Take 15-30 drops 2-3 times a day in a little fruit juice or water
Water, organic alcohol & fresh organic echinacea extract
Free Delivery
Orders over £25.00 (Please be aware an additional surcharge may be requested for orders weighing in excess of 5kg. In these circumstances, we will contact you via email once your order has been placed.)
Standard Delivery
Tracked Delivery
Varies per country (France, Germany, Italy, Spain, Australia, Canada, Japan, USA).
Shipping charges will be calculated at checkout. Delivery within 3 - 5 working days (5 - 10 working days for international orders).
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Tag: gardening club
There's a chicken in our garden
View full story
Time, I feel, for a Gardening Club update. The team have had their green fingers hard at work making the place look nice, so here, in pictures, is a tribute to their efforts: A few of us are particularly looking forward to seeing this in all its summertime glory! Office Manager, Angela, putting the finishing […]
Progress on the gardening front
View full story
There's movement! Plants have actually appeared in the big boxes outside the office – and quite an interesting array of them. There's even some kind of wire-frame chicken. Looking forward to seeing that develop… So the green-fingered brigade here at OF&G are on the march and the toxic-fingered among us are watching with interest to […]


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Monday, 3 October 2011
National Knitting Week
This special week of crafty events was first celebrated in 2005 after it was created by Knitting Magazine.
There's lots of ways to get involved. You can organise free 'knit and crochet' classes, fashion shows to show off your newly spun clothes and much more!
At the official National Knitting Week website, you can see full lists of all events in your area.
There is also a serious side to National Knitting Week - money raised will go to Bliss the special care baby charity. Last year almost £10 000 was raised to help support the Bliss Family Support Helpline. And this year the money raised will by used to help with the costs of 40,000 Going Home Pack. So with your help lets hope they can raise much more than previous years!
Knit 1 - Pass it On is National Knitting Week's latest campaign, launched by the Crafts Council and the UK Handknitting Association . The aim is to support one other person and teach them how to knit or crochet. You could even get sponsored for your efforts and raise donations for Bliss!
So go on, pick up your pins, get started on that woolly jumper and help a good cause!
Posted by Doodlebugs at 02:53
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- 癌症免疫疗法的小分子药物 -
First-generation cancer immunotherapy agents being developed or approved are engineered T cells targeting tumors or mostly antibody-based biologics that target the immune checkpoint cascade. The success of these biologics in the clinic is now inspiring the discovery and development of small molecules that act on intracellular targets affecting immuno-modulatory pathways in cancer. Cambridge Healthtech Institute's 2nd Annual Small Molecules for Cancer Immunotherapy conference brings together discovery chemists and biologists to talk about these new intracellular oncology targets and immuno-modulatory small molecule inhibitors that are being developed to act alone or in combination with existing treatments.
Final Agenda
Day 1 | Day 2
Choose 2 Short Courses
or 1 Symposium and 2 Conferences/Training Seminars
- September 25 Symposium:
Targeting Autophagy
- September 25 Short Course 3:
How to Best Utilize 3D Cells, Spheroids, and PDX Models in Oncology
- September 26-27 Conference:
Small Molecules for Cancer Immunotherapy
- September 27-28 Conference:
Targeting Tumor Myeloid Cells
- September 27 Short Course 16:
Immunology Basics
Wednesday, September 26
7:00 am Registration Open and Morning Coffee
Update On Small Molecules In Development For Immunooncology
8:00 Welcome Remarks
Tanuja Koppal, PhD, Conference Director, Cambridge Healthtech Institute
8:05 Chairperson's Opening Remarks
Paul Kassner, PhD, Vice President, Quantitative Biology, FLX Bio Inc.
8:10 Beyond PD-1 Axis: The Next Generation Oral Checkpoint Inhibitor Targeting the CD47/SIRPα Pathway for Cancer Immunotherapy
Pottayil G. Sasikumar, PhD, Associate Research Director and Head of the Peptide Chemistry group, Aurigene Discovery Technologies Limited
Encouraged by our success in discovering small molecule immune checkpoint inhibitors predominantly impacting T cells, we are now focusing on next generation checkpoint inhibitors. In this presentation, we will discuss successful identification of oral agents targeting the CD47/signal regulatory protein alpha (SIRPα) axis, a critical regulator of myeloid cell activation and a checkpoint for macrophage and dendritic-cell mediated phagocytosis and antigen presentation.
8:40 Small Molecule Immune Oncology Therapies from Ubiquitin Proteasome System
Suresh Kumar, PhD, Senior Director R&D, Progenra, Inc.
Progenra is developing small molecule inhibitors targeting deubiquitinases and ubiquitin ligases that promote tumor growth and immune evasion. The deubiquitylase (DUB) USP7 stabilizes several pro-tumorigenic proteins and plays an essential in Treg function by regulating post-translational modification of Foxp3 and TIP60. Progenra has developed potent USP7 inhibitors that exhibit direct anti-tumor activity in multiple xenograft tumor models. Most importantly, USP7 inhibitors also impair Treg functions and are efficacious in syngeneic solid tumor models.
9:10 Purine Nucleoside Phosphorylase Inhibitors as Novel, First-in-Class Small Molecule Immunotherapy
Shanta Bantia, PhD, President and CEO, Nitor Therapeutics
We have discovered, contrary to all previous literature, that purine nucleoside phosphorylase (PNP) inhibitors are immune potentiators and represent a new class of orally bioavailable, small molecule immuno-oncology therapeutics. Increase in the endogenous metabolite, guanosine, with PNP inhibition leads to activation of TLR2, 4 and 7. Potential attributes for differentiation of PNP inhibitor (NTR001) are: less adverse events from targeted immune activation in tumor micro-environment; human safety known and doses defined, and immune activation in clinical/preclinical studies confirmed.
9:40 Grand Opening Coffee Break in the Exhibit Hall with Poster Viewing
10:25 The Network-Driven Drug Discovery (NDD) Approach and Lead Generation: Novel Immune-Modulatory Small Molecules Case Study
Sree Vadlamudi, PhD, Programme Manager, e Therapeutics plc
The majority of drug discovery approaches involve the search for a single binding target in a well-characterized pathway. But while pathways are easy to envisage, they do not reflect the complexity of biological systems. A more realistic way to describe the underlying interactions which occur is as a network. We have implemented and validated a highly productive NDD approach to identify NCEs in diverse areas of biology. We will describe a case study highlighting the discovery and optimization of small molecules modulating tumor micro environment (TME) with a novel mechanism of action.
10:55 Epigenetic Control of Immune Checkpoint Inhibitor Responses
Diana Hargreaves, PhD, Assistant Professor, Molecular and Cell Biology, Salk Institute for Biological Sciences
Mutations in subunits of the SWI/SNF chromatin remodeling complex are known to potentiate responses to checkpoint therapies and are thus attractive targets for the development of small molecules for cancer therapy. Here we describe a key role for the SWI/SNF subunit ARID1A in controlling chromatin accessibility and histone modifications at transcriptional enhancers and discuss our efforts to identify novel SWI/SNF complex inhibitors.
11:25 Exhausted CD8 Cells May Predict Response to Immune Checkpoint Inhibitors in Breast Cancer
Pamela Munster, MD, Professor, Department of Medicine; Director, Early Phase Clinical Trials Unit, and Leader, Developmental Therapeutics Program, University of California San Francisco
Immune checkpoint inhibitors have limited efficacy in estrogen receptor (ER)+ breast cancer. Implicated factors include scarcity of tumor infiltrating lymphocytes (TILs), low PD-L1 expression, female gender and liver involvement. Evaluation of in vitro and in vivo effects of epigenetic modulation with HDACi on Tregs, change in TIL composition and data from a clinical trial in patients with (ER)+ metastatic breast cancer suggests that HDACi induced Treg regulation and the presence of exhausted CD8+ cells in a small subset of patients (ER)+ breast cancer patients were predictive of response.
11:55 Sponsored Presentation (Opportunity Available)
12:25 pm Session Break
12:35 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own
1:15 Refreshment Break in the Exhibit Hall with Poster Viewing
IMPACTING TLRs, CYTOKINES AND PRO-INFLAMMATORY PATHWAYS
1:50 Chairperson's Remarks
David Ferguson, PhD, Professor, Medicinal Chemistry, University of Minnesota
1:55 Development of CCR4 Antagonists for Cancer Immunotherapy
Paul Kassner, PhD, Vice President, Quantitative Biology, FLX Bio Inc.
Regulatory T cells (Treg) suppress anti-tumor immunity in the tumor micro enviroment (TME). CCR4 is highly expressed on Treg and responsible for recruitment of Treg to the TME. FLX475 is a potent and selective CCR4 antagonist in Phase I clinical trials. The preclinical development, patient selection strategy and biomarker plan for FLX475 will be discussed.
2:25 A New Approach for the Selective Suppression of Regulatory T Cell Development with Small Molecules
Karolina Ersmark, PhD, Principal Scientist and Project leader Medicinal Chemistry, Medivir AB
Selective suppression of regulatory T cells (Tregs) has previously been demonstrated to enhance the anti-tumor immune response. We have identified a biological target involved in the regulation of Tregs as a novel approach to improve responses to cancer immunotherapy. This presentation will show data demonstrating selective suppression of Tregs in vitro and in vivo by small molecule inhibition of this target. Optimization of two separate classes of inhibitors is currently in progress with the aim of selecting a final molecule for clinical development.
2:55 Sponsored Presentation (Opportunity Available)
3:25 Refreshment Break in the Exhibit Hall with Poster Viewing and Poster Competition Winner Announced
4:05 IDO1 as a Promoter of Inflammatory Neovascularization
Alexander J. Muller, PhD, Associate Professor, Lankenau Institute for Medical Research
IDO1 is a tryptophan catabolizing enzyme implicated in maintaining pregnancy and tumoral immune escape. This may, however, be just one aspect of a multifaceted role for IDO1. Our studies have determined that, by triggering the integrated stress response, IDO1 can support inflammatory neovascularization through its positioning at the regulatory interface between the inflammatory cytokines IFNγ and IL6. These insights have important ramifications for the therapeutic development of IDO1 inhibitors.
4:35 Toll-Like Receptor 7 and 8 Agonists with Direct Inflammasome Activation
David Ferguson, PhD, Professor, Medicinal Chemistry, University of Minnesota
The basic structural features of small molecule ligands that confer selectivity to Toll-like receptors 7 and 8 will be discussed in the context of immunomodulation and the design of cancer vaccines. An SAR analysis will be presented to identify structural features that confer selectivity to TLR7 and TLR8 and ligand specific activation of key cytokines in producing antigen-specific cellular responses in model systems. Finally, in vivo data will be shown that demonstrates the potential of TLR7/8 stimulation in designing advanced vaccines for cancer treatment.
5:05 Interactive Breakout Discussion Groups
Join a breakout discussion group. These are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic. Details on the topics and moderators are available on the conference website.
6:05 Welcome Reception in the Exhibit Hall
7:10 Close of Day
Day 1 | Day 2
Thursday, September 27
7:30 am Registration Open and Morning Coffee
Emerging Targets And Combinations For Cancer Immunotherapy
8:00 Chairperson's Remarks
Amar Natarajan, PhD, Professor, Eppley Institute for Cancer Research, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center
8:05 Targeting Myeloid Cell Suppressor Function through Inhibition of GCN2
Buvana Ravishankar, PhD, Scientist, Discovery Biology, FLX Bio Inc.
Myeloid-derived suppressor cells (MDSC) are a major component of the tumor microenvironment with potent immune-suppressive activity. MDSC within the tumor mediate local depletion of amino-acids that induce suppression of T cell proliferation and activation. GCN2 kinase is a stress response kinase that detects amino-acid deprivation leading to T cell anergy and apoptosis. GCN2 inhibitors abrogated the suppressive function of MDSCs leading to restoration of proliferation and effector function of CD8 T cells.
8:35 Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy
Amar Natarajan, PhD, Professor, Eppley Institute for Cancer Research, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center
Systematic CRISPR studies defined signaling arms in the apoptosis network that can be targeted for cancer therapy. Using a pair of doxycycline (Dox)-inducible cell lines that specifically report on targeting either the Mcl-1 arm or the Bcl-2/Bcl-xL/Bcl-w arm we identified unique combination of inhibitors that synergistically induce apoptosis. Here we will present preclinical studies that validate these combinations that can be rapidly translated to the clinics.
9:05 Sponsored Presentation (Opportunity Available)
9:35 Coffee Break in the Exhibit Hall with Poster Viewing
10:20 Plate-Based Approach to Identify PROTACS Molecules and Protein Degraders
Davide Gianni, PhD, Team Leader, Discovery Sciences, AstraZeneca
PROTACS provide a new modality to drug previously challenging targets and much evidence indicates that protein degraders are a mode of inhibition that can be pursued post HTS. Western Blot is mostly used to characterize PROTACS molecules, but it has a number of obvious limitations. The adoption of plate-based approaches is essential in PROTACS and several options are available such as, antibody-based and non-antibody based approaches. We will present two case studies building plate-based, HTS-friendly protein degradation assays potentially applicable for PROTACS identification campaigns.
10:50 PROTACS: The Chemical Equivalent of CRISPR
Shanique Alabi, Graduate Student, Laboratory of Dr. Craig Crews, Department of Molecular, Cellular and Developmental Biology, Yale University
Induced protein degradation offers several advantages over traditional inhibition strategies and has emerged recently as a potential therapeutic option. For the past 16 years, we have helped develop this fast-growing field, shepherding our initial chemical biology concept into a drug development strategy that is on the verge of clinical validation. PROTACs with high target selectivity, potency, and oral bioavailability will be discussed as well as a system to address the 'PROTACability' of particular E3 ligases.
11:20 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own
11:50 Conference Registration Open
12:20 pm Plenary Keynote Program
2:00 Refreshment Break in the Exhibit Hall with Poster Viewing
2:45 Close of Conference
* 活动内容有可能不事先告知作更动及调整。


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