text: Adhesion inhibitors that block the attachment of pathogens to sponsor cells may be used synergistically with or while an option to antibiotics. on sponsor cells while avoiding bacterial illness. Intro Wound infections are progressively demanding to treat due to a rise in multidrug-resistant (MDR) bacterial isolates. While MDR Gram-negative bacteria such as and progressively contribute to the profile of wound infections seen in the medical center, Gram-positives and above all methicillin-resistant (MRSA) remain a major cause of morbidity and mortality in wounded individuals [1,2]. As an option approach to antimicrobial treatment of wound infections, we are studying the potential of focusing on bacterial-host relationships using adhesion inhibitors. Prevention of bacterial attachment to sponsor cells abrogates subsequent processes facilitating illness, such as type III secretion system (Capital t3SS)-mediated effector injection into sponsor cells or cellular attack, making this a encouraging strategy for management of bacterial infections [3]. use an array of adhesins to accomplish sponsor cell attachment and attack and intrusions fibronectin as a key receptor for cell attachment and attack [4-6]. Efforts possess been made to utilize peptides produced from fibronectin-binding proteins (FnBPs) as adhesion inhibitors[6,7]. For example, a recombinant fragment of the adhesin fibronectin-binding protein A (FnBPA) reduced staphylococcal abscess formation in a guinea pig model of wound illness and experienced a synergistic effect on standard antibiotic treatment [7]. However, the competitive properties of these substances are centered on their ability to situation to the sponsor receptor fibronectin with high affinity. Since fibronectin is definitely tightly involved in a range Sav1 of cellular processes prerequisite to wound healing, such as cellular expansion, adhesion, migration and matrix formation [8], this caused undesired side-effects on sponsor cellular functions [9,10]. We have recently recognized a book family of bacterial adhesins, termed Multivalent Adhesion Substances (MAMs). MAMs are involved in initial bacterial attachment to sponsor cells and MAM homologs are found in many Gram-negative pathogens [11]. MAMs are outer membrane proteins consisting of tandem arrays of six to seven mammalian cell access (mce) domain names. The mce domain names mediate attachment to sponsor cells by high affinity connection with the sponsor membrane lipid phosphatidic acid (PA) and use fibronectin as a co-receptor [12]. Since MAM homologs are present in many bacterial varieties, the use of MAM-based inhibitors might become an approach permitting prophylaxis and eventually treatment of a broad spectrum of infections [13]. We have successfully used inhibitors centered on MAM7 to prevent infections caused by enteric pathogens in cells tradition models, and more recently we shown that this approach can become prolonged to MDR Gram-negative isolates causing wound infections [14]. Since the joining site in fibronectin acknowledged by MAM7 is definitely also acknowledged by FnBPA, we arranged out to test if the antibacterial properties of MAM7 could become prolonged to competitively prevent adhesion to sponsor cells. Additionally, we analyzed the effects of a MAM7-centered adhesion inhibitor on sponsor cellular reactions FnBPA, which experienced previously been looked into as adhesion inhibitor [7]. FnBPA mediates bacterial attachment and attack of a variety of cell types by affixing to the N-terminal region of fibronectin in a modular fashion, using a tandem -zipper mechanism [18-20]. FnBPA consists of eleven fibronectin-binding repeats (FnBRs) arranged in tandem, and the binding affinity of individual CGS 21680 HCl repeats ranges from 1nM to 3M (Number 1M), [21]. Number 1 Adhesion inhibitors protect sponsor cells from MRSA illness. Our studies demonstrate that adhesion inhibitors centered on peptides produced from adhesins N1 and FnBPA efficiently prevent bacterial adhesion but interfere CGS 21680 HCl with cellular processes advertising wound healing, as was previously described. In contrast, a MAM7-produced peptide is definitely an effective adhesion inhibitor but does not cause undesired effects on sponsor cells USA300 genomic DNA and cloned into pGEX-TEV CGS 21680 HCl using BamHI and NotI sites. Protein was indicated in BL21 and purified on glutathione sepharose as previously explained for individual FnBRs [21]. adhesion to sponsor cells GST, MAM7, N1 or FnBPA produced peptides were immobilized on latex beads as previously explained [13]. Bead-immobilized inhibitors in tradition medium CGS 21680 HCl were added to dishes comprising HeLa cells to give a final concentration of 500 nM immobilized peptides and incubated for one hour. Medium was then replaced with medium, comprising GFP-expressing USA300 (gift from V. Torres lab) at a multiplicity of illness of 10 and incubated for four hours. Cells were washed, fixed with 3.2% formaldehyde, permeabilized with 0.5% Triton X-100 in PBS and discolored for F-actin.


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Trump Dumps Prime Lawyer Who Defied Immigration Order
In a voyage or time charter the charterer charters the ship (or a part of it) for a specific voyage or for a set time frame. For instance, a travel club's members need to go on a cruise so the travel club goes to the cruise line and negotiates an important worth by buying 200-300 cabins on the ship. Nowadays, so many overseas travelers are coming to this a part of the world in an effort to expertise its culture, food and traditions. Compassion, willingness to learn and dealing as part of a team are necessary attributes for any potential travel nurse.
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text: Marden has an "A" rating according to The Better Business Bureau Business Reliability Report. The BBB assigns ratings by evaluating businesses in multiple categories. Ratings are determined by a proprietary formula that represents BBB's opinion. BBB assigns grades from A to F with pluses and minuses. A+ is the highest grade and F is the lowest. The grade represents BBB's degree of confidence that the business is operating in a trustworthy manner. An "A" means a score of 94 to 96.99 in BBB's rating system (out of 100). To learn more about BBB's rating system, click here. We are Quality Professionals Providing Quality Care.


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Sunday, February 22, 2015
Us at Duende last night
Jason Berry from Vacuum Tree Head took this photo of us playing at Duende last night. It's the last gig we'll do for a while, as we're heading back into Studio Faire la Nouba the first weekend of March to start work on our new album. The first tunes we'll be recording will be "Itzirktna" by Amanda and "Undeciphered" by Tim.
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I'm going to make a grand assertion here: Social media can work for pretty much any business… if it's used in the right way.
Some people think it's a waste of time, however, and that's fine; it's not for everyone. But I'd like to at least offer you five tips that will help get social media working for your business, if you want and need it to.
Footprint's top 5 tips for making social media work for your business
- Understand what you want out of it…
Never, ever, do social media just for the sake of it. Therein lies the path to wasted time, frustration, and disappointment. Be very clear in your mind what the purpose of engaging with your audience is, and hold onto that thought every time you log in. Is it to gain sales directly? Is it to build your brand? Is it to extend your mailing list? Is it to stay ahead of your competitors?
If you have a clear idea of what you're trying to achieve – and don't forget you can have more than one goal – it will make it far easier to craft your posts and responses.
You then need to track your performance, understand where you need to make tweaks, and assess your performance regularly.
- Understand your audience…
The questions you need to ask yourself are twofold:
- Where does my audience 'hang out'? In other words, what platforms do those people use? There's no point spending time on LinkedIn if the people you're trying to engage with are on Facebook.
- What types of posts are going to get their attention? How do I want them to engage?
So let's have a quick look at some current social media demographics for the UK.
Social media sites by their popularity
Facebook is still the biggie, and interestingly the user base is split pretty evenly between men and women. It also still has a broader reach across the generations, though probably leaning more towards the over thirties. If your market is the youngsters of the day, another platform may ensure your time is better spent.
Twitter is very actively used by people under 35 and the media, but not so much teenagers… The gender split is fairly even.
LinkedIn is very much business oriented. Users tend to be older rather than younger, and we're talking over 35. A B2B based business will find LinkedIn of greater benefit than B2C.
There are lots of other platforms to investigate too, such as Google+, Instagram, and Pinterest. Your audience is out there somewhere.
- Converse, don't transmit…
The buzz word for getting the most out of social media is 'engagement'. Be human. Don't talk AT your audience, converse WITH them. Interaction is the name of the game. Get the interactions going, and they'll start talking about you elsewhere and sharing your posts. Sounds time-consuming? It needn't be. Limit your choice of platforms to a manageable amount and don't spread yourself too thinly.
- Be prepared to put your hand up…
If your company makes a mistake see this as an opportunity to admit it and turn it around. Apologise. Thank the person for taking the time to point it out. Explain how you've taken the experience on board and changed how you operate. That individual will feel their view matters, they've been listened to, and you care. That will make them feel very differently towards your business, and the issue won't just be left to fester. There will be times, of course, when the best outcome you can hope for is simply about damage limitation… but take the opportunity to limit that damage ASAP, and move on.
- Be committed and consistent…
Out of sight is out of mind, as they say, and never was an idiom truer than in the world of social media. You need to be active, though you mustn't overdo it, and you need to be consistent. Put a human voice to your messages, and let your company values, commitment, and consistency sit behind those messages. This will enable your brand to connect with your audience in a powerful way.
I'm hoping that's given you food for thought. And if you need a little help with your social media, either through some training or an extra pair of hands to actually do some of it for you, give me a ring. I'd love to chat through what you're trying to achieve and see if Footprint can help move things forward for your business.


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Dragon's Prophet has mountable flying dragons and you know what other MMO had flying mountable dragons? WoW and you know what that means…WoW clone! But beyond that obviously overly gross generalization, Dragon's Prophet does indeed allow players to fly around on mountable flying dragons. I preface dragons with flying because Dragon's Prophet is known for having dragons that well, aren't what we would technically define as "dragons" and thus don't all posses the ability to fly.
Nonetheless, what this all is really about is the floating islands in Dragon's Prophet. The ones that require flying mounts to reach and grant the explorer their very own home on a floating island. Europe based developer-turned-published Infernum is giving one guild the chance to pull their own rendition of Howl's Moving Castle and secure several islands (I counted 10) including one with a large mansion for the Guild Leader. To be eligible to win you must and I quote "in a nutshell" explain why your guild should get access to the closed beta. Afterwards you will need to invite 10 guild members to qualify.
These houses aren't just for looks though. The developers have stated that in the future these islands will be used as the backdrop for PvP battles where guilds will vie for territory control.
Even if you think your guild's chance at winning is slim to none it may be worthline to do so anyways. All registered guilds will score early access to the closed beta and 30 days of Enjin premium, whatever that is.
If you don't have a guild and would still like to try Dragon's Prophet sooner rather than later you may be able to snag some time this coming Wednesday April 24th from 17:00 until 22:00 CEST. Full details can be found here.
If you want to sign up your guild you can visit the signup page here.
16 Readers CommentedJoin discussion
the stress test today is a joke, they are letting ppl in – 500 per hour — basically lots of ppl won't get to log in, they should have done a key giveaway (to show it was going to be limited) instead of badly stating that all are welcome to join in the stress test and wanting to get as many online at once
obviously didn't speak to the PR dept about this
meh, now they're stating that there will be up to 10,000 online over this course of 5hours released slowly (this will include those who already have access e.g founder packs etc)
well I've tried three times an hour apart each time so I'll leave them to it and won't bother with it till OB
wen you need the game go to dragons prophet website 🙂
when can i download this game.. been w8ting 4 it??
Wow, wow, wow, do only guilds get housing? Or will this feature be available to all players later on?
Wow, me. Watch the trailer next time. Geezes….
When will this be available in Australia/ north america?
i think its already out just in CBT.
ahh okay thanks 🙂
How to Train your Dragon Online.
Do I get my Night Fury ingame? XD
This is not a feature i look for in a mmorpg. They need to concentrate more on game play Than building your house crap. Unless they make it so you have to defend it from the enemy's you make during missions & quests. Maybe an assassin will sneak into your house & try to kill you while you are sleeping. Or maybe the orc band you fought at the start of the game comes back & seeks you out in a large mob to destroy you & your home. If any game that has housing would add quests like that it would be a nice feature. Other than that housing & marriage in a game is just lame to me.
im plaing)
the game is still raw and buggy
aka my mounted


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Good news: I selected another sock pattern for the Fair and I love it. Love, love, love it.
Bad news: I now have 7 days to finish knitting them, washing and blocking them.
Good news: I had the perfect skein of yarn for these socks.
Bad news: It's the same yarn base that I am using for about 300 current contract knitting pieces. It's wonderful, but all yarn has its pros and cons, and the cons for this yarn is a tendency toward splitting.
Good news: The yarn is perfect for stitch definition.
Bad news: The yarn is perfect for showing every error, including splitting.
Good news: I have one sock of the pair finished.
Bad news: Last night I had to frog the entire second sock (2-3″) because of a dumb error that was not fudgable, especially considering the yarn's perfection in showing every error.
Carrying on…


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Some women go on to write letters to their physicians and the hospitals or medical centers where they practice. If we want to prevent misdiagnosed miscarriages, I think this is a great idea.
Several years ago, Kerry shared with me her misdiagnosed story and asked me to share it on The Misdiagnosed Miscarriage site:
Later she emailed me to share that her baby boy had been born! So exciting. She also shared with me the letter she sent to the hospital as well as their response. I asked permission to share this letter/response and she gladly gave it. Hopefully this letter can help other women when they have been misdiagnosed.
Here is Kerry's e-mail to the hospital (I've blocked out any identifying dates and names blocked out for privacy reasons):
Hi there,If you could please pass this on to the manager of your obstetric ultrasound department it would be greatly appreciated.This email is regarding an early pregnancy ultrasound that I had performed at your xxxxxx department on xx xxx xxxx, ref: xxxxxx (see attached scanned report)Basically I was told that my ultrasound appearance at 6 weeks 5 days, was consistent with a blighted ovum but I'm now happily 17 weeks pregnant! I understand that the doctor's report (Dr xxxxx xxxxxx) needed to simply describe what the ultrasound found, however, I think they should have quantified their conclusion with a statement that these early scans can sometimes be wrong and that further monitoring is advised (given these early assessments have been wrong in the past and that there are some factors that can influence the image). For example, I had a tilted (retroverted) uterus which I wasn't aware of until a later scan (and the lady performing my initial scan at xxxxxx didn't notify me of this and I feel she should have, given this can interfere with the image and is quite a common occurrence especially in second pregnancies).After doing some research on blighted ova, I found out that my story can be a rather common occurrence – they receive a few cases each month apparently, on the following website: www.misdiagnosedmiscarriage.
com/mycommunityIn conclusion, I just wanted to write this email in the hope that future blighted ovum ultrasound reports may hopefully have a quantitative/explanatory note at the bottom of them, outlining that these early scans can sometimes be incorrect and for the patient to follow up with later scans if they want to. This is in the hope that people don't rush out to have a curette performed (like I was intending to do) when they may indeed still be pregnant.Thank you for your time.Regards, Kerry
and I will share the hospital's response (again, I've blocked out any identifying names for privacy reasons):
(you may click on the image of the letter for easier reading)
We do know that dates are often one to two weeks of with a tilted uterus and, thankfully, more and more doctors seem to be recognizing this as well. In fact, I excitedly blogged this last year when I found the American Pregnancy Association was finally acknowledging the link between the retroverted uterus and 'hidden' babies. Here is that post:
No Heartbeat or Baby seen at Seven Weeks? Finally, the Medical Community Recognizes it Might Be Because of Your Tilted Uterus
Also, in reference to the letter, I also believe miracles happen but in the case of blighted ova being misdiagnosed, really, it's not so much a miracle when the baby is found as much as it is a patient doctor who waits until a growing gestational sac is at least 25mm before even suggesting a blighted ovum.


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Rowan Gillis MA BA
As part of his MA, Rowan undertook an internship in the sculpture conservation department with Glasgow Museums. This involved working on a wide variety of objects and materials; ranging from classical marble statue, wooden architectural features and contemporary art installations. Many objects were large and heavy, requiring the use of specialist lifting equipment and working with a team of technicians. Rowan also undertook community outreach programmes, including consultation with Glasgow's Bengali community, to explore ethical issues regarding the treatment and display of a collection of ceremonial, Hindu murti sculptures.
After graduating, Rowan worked as a conservator on the Paisley Museums decant project, as part of the opening of a new, publicly-accessible museum store. Here he was responsible for undertaking environmental monitoring and collection surveys, as well as providing advice on developing environmental standards, pest treatment programmes and identifying hazards in the collection.
Rowan joined AOC Archaeology as a conservator in 2017. Part of his role entails conservation work for Historic Environment Scotland's (HES) call off contract, as well as objects from archaeological excavations and private clients. Rowan is experienced in undertaking conservation treatment on a wide range of objects and materials, including wood, bone, stone, metals, ceramics, textile and paper. He is trained in the use of analytical equipment, such as Fourier Tansform Infrared Spectroscopy (FTIR), Energy Dispersive X-ray Fluorescence (EDXRF), Scanning Electron microscope (SEM) and x-radiography.


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Month: Year:
Call for Papers: PBRC Student Essay Contest Fall 2016
The Pacific Basin Research Center (PBRC) is pleased to request submissions for its biannual student essay contest. Undergraduate students are encouraged to submit papers from classes written during the Fall 2016 semester. Essays should speak to the PBRC's core mission of promoting humanistic development in the Pacific Basin, although we define these criteria widely. Essays from all disciplines and fields are accepted. PBRC staff and faculty will select four winning essays, typically one per graduating class. Winning abstracts will be featured in the PBRC's newsletter, PBRC Update, and the authors will receive $50 Amazon gift cards. The deadline is Saturday, December 31st, 2016.
For submission details, please click here.


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I am planning to write-up my much longer 1 year post-HSCT follow-up post in the next week, although bear with me if it takes longer than that to accomplish. All sorts of things have been happening this past week around here and this next week will most likely be just as crazy, especially at work with this being Memorial Day Weekend here in the US. Memorial Day is another baffling holiday really. It's meant to honor those who were killed defending this country, and what do people do, celebrate by having a giant BBQ and many go camping. Seems twisted, but people don't care about the reason for the holiday, they just like a 3 day weekend from work and school… Seems fitting given the state of society right now.
But onto my blood work. So I had originally planned to do this closer to May 11th, my actual stem cell birthday, but again life got in the way. I kept planning to try to get it done before work and then I never managed to get there in time to have it done and then last week I was on my period and that really messes with my platelet counts, so I wanted to wait until several days after that to actually have it done. Which put me to Wednesday May 24th. I headed into work a bit early that day to hit the hospital to have the blood draw, prior to them closing for lunch. I normally go to another hospital clinic to have the blood draw done, but the hospital itself was more convenient this time, so went there instead. Normally there are lines and you wait forever there, but amazingly I got in right away, their updated computer system makes the check-in process much easier. Then I got called back right away. Lady managed to hit my vein first time, drew 3 tubes of blood and then I was on my way. Literally from leaving my car to head inside to leaving the parking lot was around 5 minutes, crazy fast. Can't complain. And even more shocking, for once they did not use the godawful sticky tape that rips off all my arm hair, I actually had the stretchy stuff!!!! No pain on removal, can't complain.
So even more amazing was the fact that my results literally posted in under 4 hours, I was reading over them when I was on lunch. My doctor felt my numbers were all pretty good, minus my lower white blood cell count still. So I probably will follow-up with more blood work in another 3 months if he feels it is necessary. So just for the hell of it, a couple of pics from that experience.
But down to the numbers. So as I've said every time I've posted numbers, they vary a lot person to person, and they will fluctuate a lot over the first 2 years you are home. While some counts look amazing one blood draw, the next they may be horrible, it's a vicious cycle as your body recovers from the hell you put it through. So my numbers are similar to other veterans and different from others. So this time around I did a full thyroid panel, which isn't required, but thyroid issues run rampant in those with autoimmune disease, you have 1 autoimmune disease, your odds of having others is very high, many people have 2, 3 or even 4 different diseases. Even though HSCT will wipe out the MS or whatever disease you may have, still doesn't mean you won't get others. But in general chemo also fucks with your body and messes with everything and often messes with the thyroid gland. It's fairly common for those who had HSCT to end up with thyroid issues afterwards, for some it's temporary while the body recovers, for others it is lifelong. Many people say in recovery if you somewhat crash and feel like shit with tons of old symptoms popping up, to get a complete thyroid panel, because often low or high numbers are actually causing that to happen, and with medication it makes you feel normal again. My numbers for that are all in the normal range, my TSH level itself has always been on the lower end of normal, and this time it was a bit lower than it was pre-MS and at my 3 month post-HSCT. So nothing to be concerned about at the moment, but it is something I will probably have checked again sometime in the future, especially if I ever felt any signs of it being out of whack.
I also had a metabolic panel done, which basically tests for a lot of the components of the blood. All of that was in the normal range again, so in the future I probably will not have that test done anymore
Now for the important numbers which are obtained doing a CBC (complete blood count). I will compare to the last blood work, 2-3 months ago, and discuss in more details after.
WBC: 3.45 (3.8-11.0 is normal range)
RBC: 4.35 (3.5-5.5 is normal range)
Hemoglobin: 13.7 (11.2-15.7 is normal range)
Platelets: 163 (150-420 is normal range)
Neutrophils: 2.37 (1.9-8.0 is normal range)
Lymphocytes: 0.78 (1.4-4.8 is normal range)
So compared to my last blood work 2-3 months ago my WBC counts did drop slightly, they were 3.5 last time, they are 3.45 now. RBC was 4.35 this time and 4.25 last time, so up slightly. Hemoglobin is 13.7 this time and 13.1 last time, so up slightly as well. Then my platelets now are back in normal range at 163, they were 142 last time. Neutrophils are actually up this time at 2.37 compared to 2.21 last time. And then finally lymphocytes are down slightly at 0.78 compared to 0.81 last time.
So what's that mean? Normal recovery with its fluctuating numbers! So my platelets are still on the lower end of normal, but I have mentioned in the past that my platelet counts have always been on the lower end of normal, even pre-MS. I have always bruised easily throughout life. But this time at least they are back in the normal range. Neutrophils are up a bit this time around which is a good thing, those are the numbers you really have to watch, as it is important to stay above 1.9, as below that you are neutropenic, which is not good, means you need to take a lot more precautions. As you can see my WBC counts dropped a bit and are below normal. This is common during recovery and not really a big deal, but it is something that I probably will monitor a bit more over the next year, just to ensure they do rise up to normal levels eventually. WBC counts are another number that pre-MS I have always been on the low-end of the normal range. Lymphocyte counts also dropped slightly, and while not considered in the normal range for my testing lab, they are in the normal range for other labs, so I consider that to be back in the normal range. Now I didn't post percentages of the different blood components, but everything including lymphocytes are in the normal percentages, so that is at least a good thing.
So all in all, things are about where they should be. I will probably at least have a CBC done in another 3 months to monitor my WBC, even though I really hate blood draws. When I do my much longer 1 year write-up I will do my big chart again which compared all my blood work from pre-MS, through treatment and then through recovery.


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I had not intended to boast about this recent accomplishment, but Thursday's quote of the day in the New York Times has provoked me. The quote is: "Can you any longer read Henry James or George Eliot? Do you have the patience?" The quote is from Maryanne Wolf, a professor of child development at Tufts University, in a new story about the current consensus that the book is outdated and publishers are integrating video and other razzle dazzle into books and e-books — which will now be called, of all things, "vooks." (I did not have the patience to read the NYT story in full, I will admit.)
As a matter of fact, after several failed attempts, two of which may have occurred before the advent of the Internet — which was, therefore not to blame, I have finally read, in full, George Eliot's masterpiece, Middlemarch. To be sure, it required extraordinary measures, including turning off my computer on weekends, sitting in computer-free places indoors and out, foregoing nightly TV talk fests for a while, and neglecting facebook entirely. To be honest, it also helped that I persuaded my book club to make it the September book — giving us much of the summer, and creating both peer pressure and a deadline. That I missed nothing important, and actually recreated the formerly familiar, almost-zen state of submerging oneself in an author's created world for hours at a time, has made it hard to go back to newish bad habits.
What I gained was substantial. I am prepared to conclude, in the company of a long line of readers, that Middlemarch is the greatest English novel ever written. (Of course, that matters little if our culture is giving up serious literature entirely.) The author's insights into human psychology are stunning, even 140 years later, when we are all presumably much more sophisticated about motives and thought processes. Furthermore, I forgive my younger self for not sticking with it. It is no book for a 20-year-old — or even a busy 30-year-old. Even if I had read it back then, rereading it at mid-life would yeild far greater insight. Life experience makes a real difference. I recall being too upset to by Dorothea's headstrong act of self-immolation in marrying Causabon in a state of total misapprehension of who and what he was the first time I tried. Now it seems clear enough that we all walk blind into many of our choices in life — and some of them don't work out.
One reason that the much feared impatience doesn't get in the way of reading Eliot is that she, unlike some of her contemporaries — Dickens comes to mind — does not pad her prose. You can read a long, twisting sentence if it says something substantive and interesting. The book, and I gulp to say this, warranted its 785 pages.
All of this is to say that we probably want to exercise our attention spans as we do our limbs and muscle groups, lest we lose the valuable part of our culture while Twittering madly.


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Sony Entertainment Television Asia's much publicised drama 'Amber Dhara' is currently caught up in a nasty tug-of-war between the channel and the production house.
A report in Mumbai Mirror, is suggesting that the channel has distanced itself from the show, and according to insiders if this situation persists, it won't be long before the show is pulled off air.
Apparently, while the channel's programming team wanted to incorporate some changes in the story, the producers – Vikas Seth and Siddharth Kumar Tewary (Swastik Pictures) were adamant about having it their own way. In fact, the producers wanted to take over the story, scripting and casting of new characters entirely, without consulting the creative team of the channel.
When contacted, Siddharth said, "Yes, we have been given complete freedom but there's nothing exceptional about that. Most TV producers today are allowed to do their own thing. What's wrong with that? As for how long the show will go on, Sony has not mentioned anything. Let me tell you that we are ex-employees of Sony and when Amber Dhara was conceived, we were very much a part of the channel. So, how can the channel have problems with us? Sony knows what we are doing."
According to Mumbai Mirror sources the producers have resorted to the last trick to raise the sagging TRPs of the serial. They plan to separate the conjoined twins Amber and Dhara.
Our source shoots back, "Sony's creative team knows that it is the producers' decision and ultimately they will have to bear the brunt."
Only time will tell if the new twist in the storyline will deliver audience numbers…watch this space.


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Cambridge Assessment English
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The expertise, training and experience of our staff put quality and excellence at the heart of our organisation. Their dedication and commitment have earned us the global reputation of 'experts in language assessment'.
We have over 650 staff worldwide – 505 based in the UK and around 145 in our network of 27 offices around the world. Our extended network includes more than 30,000 examiners, 2,800 examination centres, and over 52,000 registered preparation centres.
We have the largest dedicated research team of any English language assessment provider, including some of the world's leading experts in the field of language assessment, dedicated to the development and quality control of our examinations.
Christine Nuttall
Interim Chief Executive
Christine joined the organisation in 1997 and has had a number of roles, including Director of Assessment, Director of Marketing and Stakeholder Relations and, most recently, was responsible for the Partnerships, Projects and Policy department at Cambridge Assessment English.
Christine has more than 30 years of experience in the English language teaching profession, including setting up and running her own successful language school, teacher training in China and the USA, and working for the British Council for seven years in Spain and London.
Christine holds a BA in English and American Literature and a Postgraduate Diploma and an MA in TESOL. As of April 2018, Christine is acting Chief Executive of Cambridge Assessment English.
The Business and Marketing department is responsible for driving growth while supporting our customers' needs.
Sean Hayde
Director Business and Marketing
Sean is responsible for the Business and Marketing department. He joined the organisation as Development Manager for East Asia in 2001, and was Assistant Director, Business Development from 2005–2008. In an extensive career in ELT, Sean has taught English as a foreign language in Latin America, the Middle East and Europe. He also worked for the British Council in Saudi Arabia and the UK. He holds a degree in History and English from University College, Cork, and a postgraduate qualification in Business Administration from Henley Management School.
Cambridge Assessment Admissions Testing
Cambridge Assessment Admissions Testing offers a range of tests and tailored assessment services to support selection and recruitment for higher education and employment with a range of customers, including university consortia, medical councils, education ministries and professional organisations around the world.
The Digital and New Product Development department leads the development of innovative new digital assessment and learning products.
As well as our headquarters in Cambridge we have representatives in offices around the world. Our network of hubs manage our work in key regions to create a truly global operation.
Francesca Woodward
Director Global Network
Fran leads our network of offices around the world to support Cambridge English globally. Before joining Cambridge English, Fran had a sixteen-year career at Pearson, where she worked in a variety of sales leadership roles across the company's products and regions. Most recently she was Head of Pearson Qualifications and International Schools for Europe, Africa and Asia. In that role she led a large team across multiple offices with a broad portfolio including qualifications, schools' resources and English assessment. She has worked closely with schools, higher education institutions, corporate training providers, professional bodies and ministries of education.
Customer Services, Operations, Validation and Assessment is responsible for the end-to-end delivery of our examinations.
Mark Johnston
Chief Operating Officer
Mark oversees four departments; Assessment, Customer Services, Operations and Validation, with primary responsibility for the development, creation, delivery and support of the products and services of Cambridge Assessment English. This group of departments continually collaborates across Cambridge English to develop and enhance our products.
Before joining Cambridge English Mark spent five years as COO of a European Commission funded organisation responsible for delivering services to Education and Research institutions and facilities across Europe and conducting research on behalf of the EC. Before that Mark spent 20 years working in operational roles in the commercial telecommunications sector. Mark has an MBA from the University of Edinburgh.
Guy Nicholson
Director Operations
Guy is responsible for Operations, which primarily focuses on ensuring that all Cambridge English candidates get high-quality exam materials – both paper based and computer based – delivered at precisely the right time and that they receive accurate and timely results. Guy joined Cambridge English in 2004, having previously worked as an English language teacher (and later Director of Studies) in both Italy and the UK for a number of years. He holds a first degree in English Language and Literature from the University of Birmingham and an MA in Applied Linguistics and ELT from King's College London.
Andy Page
Director Customer Services
Andy is responsible for the Customer Services team which provides helpdesk, technical support, Exam Centre development, compliance, inspections and internal business support services.
Andy has 8 years' experience of teaching modern languages and 16 years of commercial experience in the technology sector. He has worked at every level in technical support contact centres (from frontline agent to operations manager). For 12 years before joining Cambridge English Andy held engineering, operational and managerial roles at Intel Corporation. Andy has always maintained, however, a passion for language learning and an interest in education.
Juliet Wilson
Director Assessment
Juliet is responsible for the Assessment department, which manages the production of all examination materials, develops new exams and modifies existing ones. Her department is responsible for the management of all testing products and assessment services, including the overall management of the examination item production system, computer-based testing and English for specific purposes exams. Before joining us in 1998, Juliet taught ESOL to adults and children in the UK, Colombia, Hong Kong and Portugal. Juliet holds a BA in French and German, a Master's degree in TESOL from the Institute of Education, University of London, and a Certificate in Management from the Judge Institute, University of Cambridge.
Partnerships, Projects and Policy leads our external relationships, including IELTS, Michigan Assessment English and our work with Cambridge University Press.
The Research and Thought Leadership department conducts in-depth research in the fields of learning, teaching and assessment of English.
Dr Nick Saville
Director Research and Thought Leadership
Nick Saville is responsible for directing the work of the Research and Thought Leadership Group. He holds a PhD from the University of Bedfordshire in language test impact, as well as degrees in Linguistics and in TEFL from the University of Reading. He has specialised in language assessment since 1987. Before joining Cambridge in 1989, he taught at the University of Cagliari, Italy, and managed test development projects in Tokyo.
Nick presents regularly at international conferences and has published widely on issues related to language assessment. He was a founding associate editor of the journal Language Assessment Quarterly (2004 onwards) and is the joint editor of the English Profile Studies series.


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03rd July 2017
We are thrilled, in this our 40th Anniversary Year, to be handing over our newly completed development at Castle Street in Comber. There has been a huge interest in this stylish development in the heart of the town with hundreds of applicants for the 16 available properties. Today, the successful tenants move into the newly finished accommodation.
With site costs of £195,000 and a contract amount of £1.5 million, the development represents a significant investment in Comber. It has been warmly welcomed by the town's residents and has received much praise for the way in which it complements the area's improvement works. Sensitively designed by RPP Architects and built by Lowry Construction, the development features a mix of natural stone faced, two bedroom apartments and pastel hued, three and four bedroom town houses with rear courtyard parking.
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With work at the site now completed and the new residents collecting the keys to their front doors, Castle Street will now become the focus of family life for 16 households. We warmly welcome the new residents and wish them all happiness in their new homes.


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439 votes 96 voters 14.4k views 18 items
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