text:
Angels Still Have Issues, but what a Difference a Few Lit Halos Can Make!
Writers are often purported to be an angsty bunch, pouring out the prose most effectively in a fit of anger or sadness. But not I. Words flow from my fingers through the keyboard most easily when I'm in a good mood and this blog is no exception. I don't want to yell at my Angels, I want to cheer for and celebrate them. Now, is this more a factor of there being little truth to the stereotype about writers or of the fact of my being a hack, I cannot say. 😉 But I can tell you that I'd far rather continue writing the post I started in a fit of baseball fan euphoria on Sunday than anything "inspired" by last night's game against the Rangers…but, don't worry. You know me. I'll bring it back around eventually.
Oh what a difference a series or even a game can make in the mood of the baseball fan! Especially when that series finds my previously slumping Angels sweeping the Tigers, scary offensive lineup and all! You would think that, as a lifelong baseball fan, I would thoroughly grok the whole 162 game season concept and not get so worked up over a series or even a week here or there. But, in truth, I think that's only possibly for the more casual fan, the fan who skims the box scores far more often than they find the time to sit down and watch a game. Because, when you watch most of those 162 games, the no less true for being so very clichéd concept of this being a marathon not a sprint, becomes strictly academic in the face of the fact that you are living the season game by game. Heck, sometimes it doesn't even take a series to provoke a completely disproportionate to the sample size at hand move to despair or jubilation. Especially this early in the season, sometimes just a game will do it. I certainly found myself embracing an impractical surge of optimism after watching the Angels' walk off win against the Astros from the Big A two Saturdays ago. And a game like last night's game against the Rangers, a game which laid bare all of the Angels flaws over the course of nine innings – see, I told you I'd bring this back around! – would have eaten at me, planting nagging doubts about the season, even in June or July.
Thus, last post I was desperately searching for a reason to stay optimistic and this weekend I was trying to temper my optimism with sane practicality and with only limited success…until last night. After the first game against the Rangers, the stark reminder of the Angels flaws did temper that optimism, but it didn't kill it. Yes, I know the Angels are far from out of the woods yet in terms of the standings…yes, even this early in the season and I will remind anyone who says 'no it's too early to worry at all' to look at last season. Yes, the starting rotation is a real problem, especially for the duration of Jered Weaver's DL stint, and the bullpen is worse. And, yes, there is an awful lot riding on a potentially brilliant but frustratingly streaky offense. But the weekend's sweep of the Tigers did at least show us what an Angels team with a fully functioning offense can do when the different components of the pitching staff combine for at least a passable performance, and what that team can do is win! Now, when the offense takes a while to come online, or is scoring but still strands too many runners in scoring position while any aspect of the pitching outright self destructs? Well, hang on to your hats ladies and gentlemen, this season could get a little interesting by all appropriately Hoban Washburne definitions of the word.
So those are the realistic concerns from the past week and change, but what about the happier observations?:
- Is there anything hotter in baseball than your team's walk off win? I mean, seriously. Is there anything more, dear lord, 'Is it getting warm in here or is it just me?,' I think I need several moments to recover and quite possibly a cigarette, hotter in baseball than a walk off win…especially one you witness live? No. Quite simply, there is not, as I was reminded from our seats at the Big A two Saturdays ago and again just this past Sunday.
- When the offense is clicking it can and will pick up even so-so pitching…and the offense is heating up. Okay, Josh Hamilton needs to catch the warming trend and we'd like Mike Trout to steal more again, but for the most part they're starting to look really good more games than not.
- Promising youth explosion! If we had to have so many injuries early on – and, let's face it, we'd all prefer that the Angels did not, but here we are – then at least the team has found two legitimate gems in the form of Garrett Richards and Luis "Lucho" Jimenez. When he last joined the Big League team, Richards had promising stuff but little seasoning. Returning from more time in the minors with a lot more polish, the youngster still has some work to do, but has nevertheless been one of the brighter spots in the rotation. And Lucho, replacing the ailing Alberto Callaspo, is simply a revelation. Good instincts, good hands, serious athleticism, some speed and no small amount of pop in his bat, not to mention an attitude with just the right amount of cockiness and an infectious grin. I find myself hoping that Lucho is Callaspo's permanent replacement and I'm one of the fans usually counted among Callaspo supporters.
- Even in our sketchy bullpen there are a few standouts. Scott Downs is Downs again. Jerome Williams is a confidence inspiring sight taking the mound in long relief and recent call up Michael Roth sure impressed in his Angels debut…in fact, one wonders why we haven't seen him since. (Editor's Note: Ah, that would be because apparently Roth is temporarily joining the starting rotation beginning tonight. I'm awfully excited to watch that. It's only the Rangers, kid, and Yu Darvish. No pressure. 😉 )
- Our outfield!! Trout, Peter Bourjos and Hamilton. I cannot get enough of the great plays from these three guys. And Bourjos haters? You go right on hating because, let's face it that's what you're going to do anyway despite anything I say or, you know, logic. But don't look now, Bourjos is hitting. Well!! And he's getting on base too. Once Hamilton settles in at the plate, this trio will be unstoppable.
And that's basically the long and the short of it. Which Angels tendencies will have more of an impact on the standings by season's end? Well it really is too soon to tell, no matter how I feel on a game by game basis. But I have more optimism than I did when last I checked in and that, dear reader, is seriously something…something I for one needed badly.


text:
Coronavirus Updates: The latest information on the global pandemic and campus operations. COVID-19 Website
Coronavirus Updates: The latest information on the global pandemic and campus operations. COVID-19 Website
Career Services at Trinity facilitates relationships for Trinity students and graduates with prospective employers, graduate school recruiters, and fellow alumni. The Career Services Offices fosters career advancement and contributes to the growth and success of Trinity graduates.
Career Services at Trinity is a comprehensive and centralized service that works with both students (from first-years to seniors) and alumni. Our office specializes in assisting students and alumni to evaluate their interests and skills, to set goals, and to research majors and occupations in light of interests, skills, and goals. Career Services is not a "placement office", but rather is part of the overall educational program at Trinity. Helping students and graduates to develop lifelong career-planning skills that they will utilize long after they leave the campus.
As part of the educational program, Career Services offers a variety of services and workshops, including Hire A Tiger, our online recruitment system. We offer services that assist students who are going on to pursue graduate study and help students to evaluate goals related to post-graduate study. The staff of Career Services also works closely with employers and recruiters to develop recruiting relationships and assist students to have access to jobs, internships, and employer information targeted specifically to Trinity students and graduates. Career Services also works closely with the Alumni Career Network. A group of over 500 Trinity Alumni who have volunteered to assist students and other Trinity graduates to access networks that can assist them to move forward with their career plans.
Learn more about how Trinity's Career Services seeks to challenge students and graduates to consider how their career plans and ultimately their careers place them in roles of community leadership and service.

subset: commoncrawl


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Why did officers not break it up?
Investigative Reporter Sarah Wallace has covered violence in the City's jails for years.
What's most disturbing about the video is that officers and inmates say it's just one example of an escalating problem of violence on Rikers, often sparked by gangs.
Officers claim there are simply not enough of them to keep the peace.
By the time officers in riot gear get into this housing unit in GRVC on RIkers island on August 5th, the inmate fight was in full swing.
"They're tossing chairs at each other, they have brooms, they have all kinds of weapons, and we're outnumbered," said Norman Seabrook, President, COBA.
Seabrook heads up the Correction Officer's union.
SARAH WALLACE: "People are going to look at this and wonder, why aren't the officers stepping in?"
NORMAN SEABROOK "Because we don't have the staff to break it up. The officers certainly can't go in there with just 3 officers against 60 inmates."
SARAH:"But the officers are just letting this happen?" "What else are we going to do?"
SEABROOK"The only thing they could possibly do at this point is watch is this point." Because going down there, they're subjected to violence that they're turning on each other, and then they turn on us. Which they've done already. So it clearly shows that there is not enough staff in the department and the management in the department has not trained correction officers properly in how to deal with these types of situations.
Seabrook says the jail is down 22 officers and that staffing in all the jails is down from 10 years ago.
"At one point, you can hear an officer yelling in vain at inmates to get back in their cells; one inmate repeatedly gets cup after cup of hot water to douse on targets," he adds.
He continues, "And that's why we took baby oil from inmates because they would mix the two together and it would stick on the body."
Seabrook goes on to say nobody called ESU units.
32 Inmates were disciplined, some will be criminally charged on assault and weapons possesion charges. The Correction Department notes there are 12,000 inmates in the system, but adds: "There is every indication that this situation could have been handled differently and that this incident went on far too long. Every issue will be addressed to prevent a reoccurrence." (Eldin Villafane, Deputy Commissioner, Public Information).
If you have a tip about this or any other issue you'd like investigated, please give our tipline a call at 877-TIP-NEWS. You may also e-mail us at firstname.lastname@example.com.
Follow Jim Hoffer on Twitter at twitter.com/nycinvestigates and on Facebook at www.facebook.com/jimhoffer.wabc
Follow Sarah Wallace on Twitter at twitter.com/sarahwallacetv and on Facebook at www.facebook.com/sarahwallace.wabc


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I have read several Origins reviews lately from fellow bloggers and each time I was like "that sounds like just what I need", so I guess you could say it was fate my bus was early haha!
This gift set was Christmas edition that retailed for around £25 I think, which is still a pretty good price seeing as the moisturiser retails for £24 alone here.
In the gift set you get the popular GinZing Energy Boosting Moisturiser 50ml, another cult favourite the Drink Up Intensive Overnight Mask 50ml, the Modern Friction Exfoliater 50ml and the GinZing Refreshing Scrub Cleanser 50ml.
GinZing Energy Boosting Moisturiser 50ml
A hydrating moisturiser is exactly what I needed so I was really looking forward to trying this out. However, after checking a few more reviews that said this was more for normal/combination skin I was slightly worried it wouldn't be suitable for my skin that's a bit dry. However, this is actually much better, in my opinion, than some creams that are infact targeted for dry skin. The reason being is that in instantly sinks in and really hydrates the skin. It has such a cooling and refreshing effect as soon as you apply it but at the same time it gives a really dewy look.
Drink Up Intensive Overnight Mask 50ml
Another product that I've been wanting to try for months! No matter how much moisturiser I put on at night, by morning my skin is just as dull and dry as if I hadn't bothered. The formula of this is like an lightweight lotion, it just sinks in quickly and doesn't really feel any different to wearing a moisturiser. So did it work? Update: Well I've been using it for atleast a year now, and I can honestly say it is absolutely worth the hype. I do tend to put on a bit more than a light layer, but when I wake up my skin is absolutely hydrated and looks quite soft and plump. It is a life saver during Winter, and I've already repurchased it in anticipation for this year.
Modern Friction Exfoliater 50ml
For me, the exfoliators were like the extras you get, I wasn't overly fussed but still excited to try them as I haven't heard much about them before. I rarely exfoliate with these grain exfoliators anymore after a few sessions with the Simple scrub left me with some broken capillaries on one of my cheeks (whoops). But at the same time I have really dry skin around my jawline that refuses to budge! The grains on this exfoliator are quite big so I wouldn't say it's as gentle as it claims. However, you can lather your face beforehand so it's not too harsh.
This has a texture than I can only compare to oatmeal. The grains are immersed in this really creamy, thick formula. I decided to just go for it around my jawline and you could really feel it shifting that dead skin, I just slightly brushed it over my cheeks but I concentrated on my jawline and forehand more. Also, I had a lot of dead, flaking skin around my nose from a really bad cold (gross I know) and this literally made light work of it. When I washed my face it was like new life had been breathed into it, it looks much better compared to a few weeks ago. I would recommend this but I would say be careful if you have sensitive skin.
GinZing Refreshing Scrub Cleanser 50ml
This is more of a toned down exfoliator compared to the above. It has a few much smaller grains in a clear gel like liquid that lathers up slightly when you apply it. It does give you quite a refreshed feeling like the accompanying GinZing moisturiser. However, just because the grains are more gentle on the skin compared to the Modern Friction exfoliator I would still not apply this too often as it does feel a bit abrasive. It is still a good product however I wouldn't say it's necessary if you have the other products.
Overall, I had a really bad cold for two weeks (hence why I've not been as active on the blogging scene) and my skin was a mess. I was breaking out, my skin was dry and itchy and so trying these products couldn't have come at a better time. Now my skin is much more hydrated, the dry patches are fading and the little breakouts are already disappearing. I would really recommend all of these products even though my budget is more drugstore normally, and I for one cannot wait to see what else Origins has in store!


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Ever wonder why yeast make alcohol? Probably not, I realize, but you should. Yeast throw off ethanol in the process of metabolizing sugar, so alcohol is a byproduct of survival; fair enough. But alcoholic fermentation is, in fact, a surprisingly inefficient way to get energy. The standard oxygen-requiring way of breaking down sugar used by most cells, our own included, wrings somewhere between 30 and 38 ATP (38 is the ideal number; it's probably never quite that high in practice) out of a single glucose molecule. (ATP is the cellular currency in which energy is transferred and spent.) Nevertheless, alcoholic fermentation has the distinct advantage of not needing oxygen and so it makes perfectly good, intuitive sense for Saccharomyces cerevisiae to use it when oxygen isn't available.
Here's the quirk: S. cerevisiae uses inefficient alcoholic fermentation even when it does have access to oxygen, even though it has the machinery for the much, much more energetically worthwhile aerobic metabolic process. Yeast will only switch to aerobic metabolism when the amount of sugar available for them to eat is very low. Why? A good question, and one microbiologists haven't had much success answering.
Our best hypothesis according to a brand-new review on the subject comes in two parts:
- Alcoholic fermentation lets yeast act fast to use up the "public goods" while squirreling away private resources for later. Every microorganism you'll encounter in grape juice can consume sugar. Very few can also consume (and get energy out of) ethanol, but yeast can. So, by converting sugar to ethanol, S. cerevisiae can starve out other microbes and leave itself with a food source for later.
- As an additional and maybe even bigger benefit, ethanol is toxic to most yeast and bacteria at concentrations that Saccharomyces can tolerate with relative ease
Possibly the most bizarre thing? We don't know much about what determines the circumstances under which S. cerevisiae, our long-time compatriot and coworker, produces alcohol versus making energy in some other way. We've looked at when and where different yeast genes are expressed and when and where it makes different byproducts but, like so much else in the wonderful and frustrating world of modern-day genetics, putting together the whole story is still a work-in-progress.


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Dental hygiene available at NTCC teaching clinic
- Details
- Category: School
- Published on 25 August 2013
- Written by Mount Vernon Optic-Herald
The fall semester is about to start at Northeast Texas Community College. This means that dental hygiene students will be back in the clinic providing low-cost services to the community as of August 27.
A flat nominal fee of only $30 for adults and $15 for children, NTCC students, and NTCC employees is charged to receive dental hygiene services. For more information, see the August 22 edition of the Mount Vernon Optic-Herald.


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Ccie Lab Material
- 1. TS: 2 sets topology, TS1 Ts2
- 2. DIAG: 8sets
- 3. CFG: 3sets topology,H1 CFG,H1+CFG,H2 CFG,H2+CFG,H3 CFG
1) TS:TS have 2 topology, TS1 and TS2,you will face one of them on exam ,our TS include all of the faults on exam.
2) DIAG:DIAG have 8 Sets, you will face one of them.
3) CFG:CFG have 2 topology,every topology include 2 Sets CFG,so you need practice 4 Sets CFG. We call H1 CFG、H1+ CFG、H2 CFG、H2+ CFG.
H1 CFG and H1+ CFG 95% are the same. just some request is different.
H2 CFG and H2+ CFG 85% are the same ,just some request is different.
H3 CFG is new CFG.
Cisco Pass Report View More >
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CCIE Security Lab
CCIE R&S v5.0 LAB Exam Format
CCIE R&S v5.0 LAB exam include 3 models(TS、DIAG and CFG).
The total score of lab exam is 100 points ,if you get 80% every model ,you will get your CCIE number.
TS:TS total score is 24 points,TS have 10 tickets,There are 2 tickets is 4 points, 8 tickets is 2 points,if you get greater or equal to 20 points,you will pass.
DIAG:DIAG total score is 6 points,DIAG have 6 tickets, if you get greater or equal to 4 points,you will pass.
CFG:CFG total score is 70 points,CFG have 5 section, if you get greater or equal to 56 points,you will pass.
How to complete lab training Download PDF
CCIE RS v5.0 LAB Examination Content1)TS:2 sets topology,TS1 TS2
2)DIAG:8 sets
3)CFG:3 sets topology,H1 CFG、H1+ CFG、H2 CFG、H2+ CFG、H3 CFG
SPOTO Collaboration CCNP Dumps AdvantageQuality and Value for the Collaboration CCNP Exam
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Ccie Lab Material
- 1997 Reviews
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text:
Italian Leather Ostrich Effect Backpack: Emerald & Tan
An understated design, this ostrich effect shoulder bag can also be worn as a backpack. It is beautifully designed in a structured shape and is secured with a top zip fastening. It features two outer pockets and internally it is fully lined.
Smart and versatile.
Features include:-
• Style No - AA0102
• Italian leather ostrich effect finish
• Fully lined
• External vertical zipped pocket - both sides
• Two main compartments with central zipped pocket
• Zipped top fastening
• Inner zip pocket
• Slip pocket
• Twin handles
• Silver-tone finish
• H25 x W28 x D8cm approx.
• Shoulder drop: 31cm approx.


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SOCHI, Russia -- Before the Olympic hockey tournament began, Russian superstar Alexander Ovechkin joked that if his country were to prevail at the sport it once dominated internationally, "it means gold only costs $50 billion," the price tag for the Sochi Games.
Apparently, $50 billion doesn't buy what it used to.
Despite assembling a powerfully talented lineup with immense scoring potential, Team Russia was eliminated from the hockey tournament Wednesday when it fell to Finland, 3-1, in a quarterfinal game at the Bolshoy Ice Dome.
Hockey had been the focus of the Games for many Russian fans, who were hoping home-ice advantage would lead to the team's first gold medal since 1988. However, the Russian team never unleashed its scoring potential, as Evgeni Malkin and Alexander Ovechkin each scored only one goal and a shaky defense proved the team's undoing.
At the same time, Finland was the better team on Wednesday, overcoming an early 1-0 deficit on goals by Juhumatti Aaltonen, Ducks right wing Teemu Selanne and standout Minnesota Wild forward Mikael Granlund. Finland goalie Tuukka Rask of the Boston Bruins stopped 37 shots.
Selanne and Granlund assisted on each other's goals, displaying a remarkable affinity despite their considerable age gap. Selanne, 43, made his Olympic debut at the 1992 Albertville Games -- a few weeks before Granlund was born.
Finland will face traditional rival Sweden in one semifinal on Friday. The other semifinal will match the winners of Wednesday's late quarterfinal games, Canada vs. Latvia and the U.S. vs. the Czech Republic.
Russia scored first Wednesday, on a power play it had gained when Granlund was sent off for holding. Pavel Datsyuk of the Detroit Red Wings set it up with a pass from the right circle to Ilya Kovalchuk in the high slot, and Kovalchuk's blistering shot got past Rask at 7:51.
Finland responded quickly. Petri Kontiola won a faceoff in Russia's end and got the puck to Juhamatti Aaltonen, who faked defenseman Nikita Nikitin out of his skates and drove to the net before taking a shot that got between Varlamov's left arm and body at 9:18.
Selanne gave Finland the lead with help from his 21-year-old linemate. Granlund used his strength and speed to get around Russia and Kings defenseman Slava Voynov before passing the puck to Selanne, who nudged it under a sliding Varlamov for his second goal of the tournament. That extended his own career Olympic scoring record to 40 points over six Winter Games.
Selanne also extended his own record for being the oldest player to score a goal in the Olympic hockey tournament, 43 years, 261 days.
A penalty that was painful for Russia in more ways than one led to Finland's third goal and silenced the crowd.
Russia defensemen Alexei Emelin upended Finnish forward Lauri Korpikoski in front of the net, and as Korpikoski was falling, his stick struck Emelin in the mouth. Emelin dripped blood onto the ice before he went for treatment, and then to the penalty box.
Finland capitalized on the man advantage at 5:37, controlling the puck and working it down low, where Selanne took a shot. He didn't get all of it but he got enough for it to bounce in front, where Granlund pounced on it and tucked it inside the post.
After that goal, Russia Coach Zinetula Bilyaletdinov pulled starting goalie Semyon Varlamov and replaced him with Sergei Bobrovsky.
Rask stopped Syomin on a breakaway with a nifty sliding stop, and Finland went on to kill a penalty against Aaltonen in the second period.
Russia pressed frantically in the third period, urged on by the hometown crowd, but the Finns continued to block shots and clamp down defensively.
Latest Olympics


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The LGBT Center of Raleigh is physically closed due to the ongoing COVID-19 pandemic, but we continue to meet virtually! Those virtual offerings can be found here. If you have questions or are seeking resources, you can call 919-832-4484 seven days a week between the hours of 12pm and 4pm, and your call will be answered by a staff member or volunteer.
We continue to work with our partners at the Alliance of AIDS Services - Carolina on creating a plan to resume HIV and STI testing at the Center and will make an announcement by the end of July!
Thank you and we look forward to seeing you again soon!
|HIV/STI Testing
- Program/Event:
- HIV/STI Testing at the Center
- Event status:
- Confirmed
- Event date:
- Monday, September 02, 2019 5pm - 7:45pm
- Location:
- LGBT Center of Raleigh, 119 East Hargett St, Raleigh NC 27601
- Center Room:
- Testing Area
- Event Contact:
- LGBT Center of Raleigh
- Contact Phone:
- 919-832-4484
- Contact E-mail:
- email@example.com
Free, confidential testing for HIV and other Sexually-Transmitted Infections is provided at the LGBT Center by the Alliance of AIDS Services - Carolina every Monday and Thursday evening. Please arrive before 7:45 pm. Thanks!


text:
Cardinals Blank Blue Jays 5-0
TORONTO (AP) - Shelby Miller took a no-hit bid into the sixth inning and finished with a three-hit shutout as the St. Louis Cardinals beat Toronto 5-0 on Saturday, snapping the Blue Jays' six-game winning streak.
Randal Grichuk hit his first career home run as the Cardinals won for only the third time in 11 games.
Miller (7-5) retired the first 13 batters before walking Adam Lind in the fifth.
Jose Reyes lined a single to right field with two outs in the sixth for Toronto's first hit. Melky Cabrera followed with a ball that nicked first baseman Allen Craig's glove for a double, but Miller struck out Jose Bautista swinging at a high fastball to end the inning.
Mark Buehrle (10-2) had won six straight decisions. Grichuk's solo homer was the only run Buehrle allowed in seven innings.


text:
The domain within your query sequence starts at position 74 and ends at position 210; the E-value for the KISc domain shown below is 2e-41.
The domain was found using the schnipsel database
KIScKinesin motor, catalytic domain. ATPase.
|SMART accession number:
|Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division.
|Interpro abstract (IPR001752):
Kinesin [(PUBMED:8542443), (PUBMED:2142876), (PUBMED:14732151)] is a microtubule-associated force-producing protein that may play a role in organelle transport. The kinesin motor activity is directed toward the microtubule's plus end. Kinesin is an oligomeric complex composed of two heavy chains and two light chains. The maintenance of the quaternary structure does not require interchain disulphide bonds.
The heavy chain is composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it is known to hydrolyse ATP, to bind and move on microtubules), a central alpha-helical coiled coil domain that mediates the heavy chain dimerisation; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
The kinesin motor domain comprises five motifs, namely N1 (P-loop), N2 (Switch I), N3 (Switch II), N4 and L2 (KVD finger) [(PUBMED:20587735)]. It has a mixed eight stranded beta-sheet core with flanking solvent exposed alpha-helices and a small three-stranded antiparallel beta-sheet in the N-terminal region [(PUBMED:15236970)].
A number of proteins have been recently found that contain a domain similar to that of the kinesin 'motor' domain [(PUBMED:8542443), (PUBMED:1832505)]:
The kinesin motor domain is located in the N-terminal part of most of the above proteins, with the exception of KAR3, klpA, and ncd where it is located in the C-terminal section.
The kinesin motor domain contains about 330 amino acids. An ATP-binding motif of type A is found near position 80 to 90, the C-terminal half of the domain is involved in microtubule-binding.
|GO process:
|microtubule-based movement (GO:0007018)
|GO function:
|microtubule motor activity (GO:0003777), ATP binding (GO:0005524), microtubule binding (GO:0008017)
|Family alignment:
There are 50033 KISc domains in 50005 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing KISc domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with KISc domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing KISc domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
Binding / catalysis: ATP-hydrolysis
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Arnal I, Wade RH
- Nucleotide-dependent conformations of the kinesin dimer interacting with microtubules.
- Structure. 1998; 6: 33-8
- Display abstract
BACKGROUND: Kinesins are crucial to eukaryotic cells. They are a superfamily of motor proteins that use ATP hydrolysis to move along microtubules. Many of these motors are heterotetramers with two heavy and two light chains. The heavy chain has a globular motor domain that interacts with microtubules and shows a similar sequence throughout the family. Compared with myosin and dynein, kinesin provides a 'simple' model for understanding molecular motors. RESULTS: Electron cryomicroscopy and three-dimensional reconstruction methods have been used to investigate microtubule-kinesin dimer complexes in different nucleotide states. Three-dimensional maps were obtained in the presence of 5'-adenylylimidodiphosphate (AMP-PNP), ADP-AIF4, ADP and apyrase. In all cases, kinesin has one attached and one free head per tubulin heterodimer. The attached heads appear very similar whereas the free heads show distinct conformations and orientations depending on their nucleotide states. CONCLUSIONS: The kinesin dimer is likely to undergo considerable conformational changes during its ATP hydrolysis cycle. In all nucleotide states, the kinesin dimer attaches to a microtubule using one motor domain with the other motor domain hanging free. Only the free domain changes conformation in the presence of different nucleotides, suggesting that it, or the region linking both motor domains to the coiled coil, is the determinant of directionality. These results give some structural clues as to how kinesin moves along microtubules and we describe possible models of kinesin movement based on currently available data.
- Block SM
- Kinesin: what gives?
- Cell. 1998; 93: 5-8
- Block SM
- Leading the procession: new insights into kinesin motors.
- J Cell Biol. 1998; 140: 1281-4
- Hirokawa N
- Kinesin and dynein superfamily proteins and the mechanism of organelle transport.
- Science. 1998; 279: 519-26
- Display abstract
Cells transport and sort proteins and lipids, after their synthesis, to various destinations at appropriate velocities in membranous organelles and protein complexes. Intracellular transport is thus fundamental to cellular morphogenesis and functioning. Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.
- Cross RA
- Molecular motors: the natural economy of kinesin.
- Curr Biol. 1997; 7: 6313-6313
- Display abstract
Kinesin is a molecular-scale walking machine. New analyses of its mechanism indicate that each step along a microtubule consumes one ATP molecule, and that the binding and cleavage of ATP precede detachment of the molecule's 'feet'. Directional walking ensues if ATP processing occurs preferentially on one foot.
- Hirokawa N
- The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors.
- Curr Opin Neurobiol. 1997; 7: 605-14
- Display abstract
Progress in the identification and characterization of new carboxy-terminal motor domain type kinesin superfamily proteins (KIFs)-KIFC2, 16 new KIFs and KIF-associated protein 3 (KAP3)-has provided further insight into the molecular mechanisms of organelle transport in neurons. Developments in molecular and cellular biophysics and recombinant adenovirus infection techniques combined with transgenic mice technology have enhanced the visualization of moving forms of cytoskeletal proteins during slow transport. The results of these studies strongly support the subunit transport theory.
- Kozielski F et al.
- The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
- Cell. 1997; 91: 985-94
- Display abstract
The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helical interaction of their necks. They are broadly similar to one another; differences are most apparent in the head-neck junction and in a moderate reorientation of the neck helices in order to adopt to the coiled-coil conformation. The heads show a rotational symmetry (approximately 120 degrees) about an axis close to that of the coiled-coil. This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules.
- Sack S et al.
- X-ray structure of motor and neck domains from rat brain kinesin.
- Biochemistry. 1997; 36: 16155-65
- Display abstract
We have determined the X-ray structure of rat kinesin head and neck domains. The folding of the core motor domain resembles that of human kinesin reported recently [Kull, F. J., et al. (1996) Nature 380, 550-554]. Novel features of the structure include the N-terminal region, folded as a beta-strand, and the C-terminal transition from the motor to the rod domain, folded as two beta-strands plus an alpha-helix. This helix is the beginning of kinesin's neck responsible for dimerization of the motor complex and for force transduction. Although the folding of the motor domain core is similar to that of a domain of myosin (an actin-dependent motor), the position and angle of kinesin's neck are very different from those of myosin's stalk, suggesting that the two motors have different mechanisms of force transduction. The N- and C-terminal ends of the core motor, thought to be responsible for the directionality of the motors [Case, R. B., et al. (1997) Cell 90, 959-966], take the form of beta-strands attached to the central beta-sheet of the structure.
- Vale RD, Fletterick RJ
- The design plan of kinesin motors.
- Annu Rev Cell Dev Biol. 1997; 13: 745-77
- Display abstract
The kinesin superfamily comprises a large and structurally diverse group of microtubule-based motor proteins that produce a variety of force-generating activities within cells. This review addresses how the structures of kinesin proteins provide clues as to their biological functions and motile properties. We discuss structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities. We also discuss how the kinesin motor domain uses chemical energy from ATP hydrolysis to move along microtubules.
- Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD
- Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.
- Nature. 1996; 380: 550-5
- Display abstract
Kinesin is the founding member of a superfamily of microtubule based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. It has two identical approximately 960-amino-acid chains containing an amino-terminal globular motor domain, a central alpha-helical region that enables dimer formation through a coiled-coil, and a carboxy-terminal tail domain that binds light chains and possibly an organelle receptor. The kinesin motor domain of approximately 340 amino acids, which can produce movement in vitro, is much smaller than that of myosin (approximately 850 amino acids) and dynein (1,000 amino acids), and is the smallest known molecular motor. Here, we report the crystal structure of the human kinesin motor domain with bound ADP determined to 1.8-A resolution by X-ray crystallography. The motor consists primarily of a single alpha/beta arrowhead-shaped domain with dimensions of 70 x 45 x 45 A. Unexpectedly, it has a striking structural similarity to the core of the catalytic domain of the actin-based motor myosin. Although kinesin and myosin have virtually no amino-acid sequence++ identity, and exhibit distinct enzymatic and motile properties, our results suggest that these two classes of mechanochemical enzymes evolved from a common ancestor and share a similar force-generating strategy.
- Moore JD, Endow SA
- Kinesin proteins: a phylum of motors for microtubule-based motility.
- Bioessays. 1996; 18: 207-19
- Display abstract
The cellular processes of transport, division and, possibly, early development all involve microtubule-based motors. Recent work shows that, unexpectedly, many of these cellular functions are carried out by different types of kinesin and kinesin-related motor proteins. The kinesin proteins are a large and rapidly growing family of microtubule-motor proteins that share a 340-amino-acid motor domain. Phylogenetic analysis of the conserved motor domains groups the kinesin proteins into a number of subfamilies, the members of which exhibit a common molecular organization and related functions. The kinesin proteins that belong to different subfamilies differ in their rates and polarity of movement along microtubules, and probably in the particles/organelles that they transport. The kinesins arose early in eukaryotic evolution and gene duplication has allowed functional specialization to occur, resulting in a surprisingly large number of different classes of these proteins adapted for intracellular transport of vesicles and organelles, and for assembly and force generation in the meiotic and mitotic spindles.
- Rayment I
- Kinesin and myosin: molecular motors with similar engines.
- Structure. 1996; 4: 501-4
- Display abstract
Structure determination of the catalytic domains of two members of the kinesin superfamily reveals that this class of molecular motor exhibits the same architecture as myosin and suggests that these microtubule- and actin-based motors arose from a common ancestor.
- Smith CA, Rayment I
- X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution.
- Biochemistry. 1996; 35: 5404-17
- Display abstract
The structure of the vanadate-trapped ADP complex of a truncated head of Dictyostelium myosin II consisting of residues Asp 2-Asn 762 has been determined by molecular replacement at 1.9 A resolution and refined to a crystallographic R-factor of 19.4%. The crystals belong to the orthorhombic space group C2221 where a = 84.50 A, b = 145.4 A, and c = 152.8 A. The conformation of the protein is similar to that of MgADP.AlF4.SlDc [Fisher, A.J., et al. (1995) Biochemistry 34, 8960-8972]. The nucleotide binding site contains a complex between MgADP and vanadate where MgADP exhibits a very similar conformation to that seen in previous complexes. The vanadate ion adopts a trigonal bipyramidal coordination. The three equatorial oxygen ligands are fairly short, average 1.7 A, relative to a single bond distance of approximately 1.8 A and are coordinated to the magnesium ion, N zeta of Lys 185, and five other protein ligands. The apical coordination to the vanadate ion is filled by a terminal oxygen on the beta-phosphate of ADP and a water molecule at bond distances of 2.1 and 2.3 A, respectively. The long length of the apical bonds suggests that the bond order is considerably less than unity. This structure confirms the earlier suggestion that vanadate is a model for the transition state of ATP hydrolysis and thus provides insight into those factors that are responsible for catalysis. In particular, it shows that the protein ligands and water structure surrounding the gamma-phosphate pocket are oriented to stabilize a water molecule in an appropriate position for in-line nucleophilic attack on the gamma-phosphorus of ATP. This structure reveals also an orientation of the COOH-terminal region beyond Thr 688 which is very different from that observed in either MgADP.BeFx.SlDc or chicken skeletal myosin subfragment 1. This is consistent with the COOH-terminal region of the molecule playing an important role in the transduction of chemical energy of hydrolysis of ATP into mechanical movement.
- Bloom GS, Endow SA
- Motor proteins 1: kinesins.
- Protein Profile. 1995; 2: 1105-71
- Display abstract
Progress regarding the kinesins is now being made at a rapid and accelerating rate. The in vivo-functions, and biophysical and enzymatic properties of kinesin itself are being explored at ever increasing levels of detail. The kinesin-related proteins now number several dozen, and although more is known about primary structure than function for most of the proteins, this trend is already reversing. For example, knowledge about the kinesin-related protein, ncd, is expanding rapidly, and more is already known about its three-dimensional structure than is known for kinesin heavy chain. This volume presents a comprehensive review of the major published works on kinesin and kinesin-related proteins. Hopefully, this manuscript will complement other recent review articles [17, 20, 25, 37, 60-62, 67, 69, 75, 85-88, 231, 233, 238, 244, 269-271, 281, 282, 292] or books [49, 227, 293] that have focused on more selective aspects of the kinesin family, or have been aimed more generally at MT motor proteins. In line with the stated purpose of the Protein Profile series, annual updates of the review on the kinesins are planned for at least the next few years.
- Fisher AJ et al.
- X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.
- Biochemistry. 1995; 34: 8960-72
- Display abstract
The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II complexed with beryllium and aluminum fluoride and magnesium ADP are reported at 2.0 and 2.6 A resolution, respectively. Crystals of the beryllium fluoride-MgADP complex belong to space group P2(1)2(1)2 with unit cell parameters of a = 105.3 A, b = 182.6 A, and c = 54.7 A, whereas the crystals of the aluminum fluoride complex belong to the orthorhombic space group C222(1) with unit cell dimensions of a = 87.9 A, b = 149.0 A, and c = 153.8 A. Chemical modification was not necessary to obtain these crystals. These structures reveal the location of the nucleotide complexes and define the amino acid residues that form the active site. The tertiary structure of the protein complexed with MgADP.BeFx is essentially identical to that observed previously in the three-dimensional model of chicken skeletal muscle myosin subfragment-1 in which no nucleotide was present. By contrast, the complex with MgADP.AlF4- exhibits significant domain movements. The structures suggest that the MgADP.BeFx complex mimics the ATP bound state and the MgADP.AlF4- complex is an analog of the transition state for hydrolysis. The domain movements observed in the MgADP.AlF4- complex indicate that myosin undergoes a conformational change during hydrolysis that is not associated with the nucleotide binding pocket but rather occurs in the COOH-terminal segment of the myosin motor domain.
- Smith CA, Rayment I
- X-ray structure of the magnesium(II)-pyrophosphate complex of the truncated head of Dictyostelium discoideum myosin to 2.7 A resolution.
- Biochemistry. 1995; 34: 8973-81
- Display abstract
The structure of the magnesium pyrophosphate complex of the truncated head of Dictyostelium myosin has been determined by molecular replacement at 2.7 A resolution and refined to a crystallographic R-factor of 16.0%. The crystals belong to the orthorhombic space group P2(1)2(1)2, where a = 105.2 A, b = 182.1 A, and c = 54.5 A. The conformation of the protein around the magnesium pyrophosphate is very similar to that seen when magnesium ADP-beryllium fluoride binds in the active site. The latter complex mimics the binding of ATP prior to hydrolysis. The pyrophosphate molecule occupies the beta- and gamma-phosphate sites, where the two phosphorus atoms are in the same positions as the beta-phosphate and the BeFx moiety of the beryllium fluoride-trapped ADP. The surrounding active site residues are almost perfectly superimposable in the two structures and the hydrogen-bonding interactions that the PPi makes with the protein are essentially identical. The similarity between the MgPPi and MgADP.BeFx complex with S1Dc suggests that the conformational change, which occurs when ATP binds to actomyosin and which reduces the affinity of myosin for actin, is caused by the binding of the gamma- and beta-phosphate groups of the nucleotide. This then implies that the role of the remainder of the substrate is to increase the binding affinity for myosin and thus to drive the equilibrium toward dissociation of myosin from actin.
- Rayment I, Holden HM
- The three-dimensional structure of a molecular motor.
- Trends Biochem Sci. 1994; 19: 129-34
- Display abstract
Myosin is one of only three proteins known to convert chemical energy into mechanical work. Although the chemical, kinetic and physiological characteristics of this protein have been studied extensively, it has been difficult to define its molecular basis of movement. With the recent X-ray structural determination of the myosin head, however, it is now possible to put forward a hypothesis on how myosin might function as a molecular motor.
- Metabolism (metabolic pathways involving proteins which contain this domain)
% proteins involved KEGG pathway ID Description 50.00 map05217 Basal cell carcinoma 50.00 map04340 Hedgehog signaling pathway
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with KISc domain which could be assigned to a KEGG orthologous group, and not all proteins containing KISc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of KISc domains in PDB
PDB code Main view Title 1bg2 HUMAN UBIQUITOUS KINESIN MOTOR DOMAIN 1cz7 THE CRYSTAL STRUCTURE OF A MINUS-END DIRECTED MICROTUBULE MOTOR PROTEIN NCD REVEALS VARIABLE DIMER CONFORMATIONS 1f9t CRYSTAL STRUCTURES OF KINESIN MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE MOTOR ATPASE 1f9u CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE 1f9v CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE 1f9w CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE 1goj Structure of a fast kinesin: Implications for ATPase mechanism and interactions with microtubules 1i5s CRYSTAL STRUCTURE OF THE KIF1A MOTOR DOMAIN COMPLEXED WITH MG-ADP 1i6i CRYSTAL STRUCTURE OF THE KIF1A MOTOR DOMAIN COMPLEXED WITH MG-AMPPCP 1ia0 KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM 1ii6 Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP. 1mkj Human Kinesin Motor Domain With Docked Neck Linker 1n6m Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd 1q0b Crystal structure of the motor protein KSP in complex with ADP and monastrol 1ry6 Crystal Structure of Internal Kinesin Motor Domain 1sdm Crystal structure of kinesin-like calmodulin binding protein 1t5c Crystal structure of the motor domain of human kinetochore protein CENP-E 1v8j The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-ADP 1v8k The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-AMPPNP 1vfv Crystal Structure of the Kif1A Motor Domain Complexed With Mg-AMPPNP 1vfw Crystal Structure of the Kif1A Motor Domain Complexed With Mg-AMPPNP 1vfx Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-AlFx 1vfz Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-VO4 1x88 Human Eg5 motor domain bound to Mg-ADP and monastrol 1yrs Crystal structure of KSP in complex with inhibitor 1 2fky crystal structure of KSP in complex with inhibitor 13 2fl2 crystal structure of KSP in complex with inhibitor 19 2fl6 crystal structure of KSP in complex with inhibitor 6 2fme Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide 2g1q crystal structure of KSP in complex with inhibitor 9h 2gm1 Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide 2gry Crystal structure of the human KIF2 motor domain in complex with ADP 2h58 Crystal structure of the KIFC3 motor domain in complex with ADP 2heh Crystal Structure of the KIF2C motor domain (CASP Target) 2hxf KIF1A head-microtubule complex structure in amppnp-form 2hxh KIF1A head-microtubule complex structure in adp-form 2ieh Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer 2kin KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS 2ncd NCD (NON-CLARET DISJUNCTIONAL) DIMER FROM D. MELANOGASTER 2owm Motor domain of Neurospora crassa kinesin-3 (NcKin3) 2p4n Human Monomeric Kinesin (1BG2) and Bovine Tubulin (1JFF) Docked into the 9-Angstrom Cryo-EM Map of Nucleotide-Free Kinesin Complexed to the Microtubule 2pg2 Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 15 2q2y Crystal Structure of KSP in complex with Inhibitor 1 2q2z Crystal Structure of KSP in Complex with Inhibitor 22 2rep Crystal structure of the motor domain of human kinesin family member C1 2uyi Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33 2uym Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 37 2vvg Crystal Structure of the G.intestinalis Kinesin 2 GiKIN2a Motor Domain 2wbe Kinesin-5-Tubulin Complex with AMPPNP 2wog Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine 2x2r Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid 2x7c Crystal structure of human kinesin Eg5 in complex with (S)-enastron 2x7d Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron 2x7e Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol 2xae Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid 2xt3 HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING 2y5w Crystal structure of Drosophila melanogaster kinesin-1 motor domain dimer 2y65 Crystal structure of Drosophila melanogaster kinesin-1 motor domain dimer-tail complex 2zfi Crystal Structure of the Kif1A Motor Domain Before Mg Release 2zfj Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-1 2zfk Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-2 2zfl Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-3 2zfm Crystal Structure of the Kif1A Motor Domain After Mg Release 3b6u Crystal structure of the motor domain of human kinesin family member 3B in complex with ADP 3b6v Crystal structure of the motor domain of human kinesin family member 3C in complex with ADP 3bfn Crystal structure of the motor domain of human kinesin family member 22 3cjo Crystal structure of KSP in complex with inhibitor 30 3cnz Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein 3cob Structural Dynamics of the Microtubule binding and regulatory elements in the Kinesin-like Calmodulin binding protein 3dc4 Crystal structure of the Drosophila kinesin family member NOD in complex with ADP 3dcb Crystal structure of the Drosophila kinesin family member NOD in complex with AMPPNP 3dco Drosophila NOD (3DC4) and Bovine Tubulin (1JFF) Docked into the 11-Angstrom Cryo-EM Map of Nucleotide-Free NOD Complexed to the Microtubule 3edl Kinesin13-Microtubule Ring complex 3gbj Crystal structure of the motor domain of kinesin KIF13B bound with ADP 3h4s Structure of the complex of a mitotic kinesin with its calcium binding regulator 3hqd Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+ 3j2u Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule 3j6h 3J6H 3j8x 3J8X 3j8y 3J8Y 3k3b Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline 3k5e The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol. 3kar THE MOTOR DOMAIN OF KINESIN-LIKE PROTEIN KAR3, A SACCHAROMYCES CEREVISIAE KINESIN-RELATED PROTEIN 3ken Human Eg5 in complex with S-trityl-L-cysteine 3kin KINESIN (DIMERIC) FROM RATTUS NORVEGICUS 3l1c Kinesin-14 Protein Ncd, T436S Mutant 3l9h X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085 3lre Crystal Structure Analysis of Human Kinesin-8 Motor Domain 3nwn Crystal structure of the human KIF9 motor domain in complex with ADP 3pxn Crystal structure of the Drosophila kinesin family member Kin10/NOD in complex with divalent manganese and ADP 3t0q Motor Domain Structure of the Kar3-like kinesin from Ashbya gossypii 3u06 Crystal structure of the kinesin-14 NcdG347D 3wpn 3WPN 3wrd 3WRD 3x2t 3X2T 3zcw Eg5 - New allosteric binding site 3zfc Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP 3zfd Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP 4a14 HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING 4a1z Eg5-1 4a28 Eg5-2 4a50 Crystal structure of human kinesin Eg5 in complex with 2-Amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid 4a51 Crystal structure of human kinesin Eg5 in complex with 1-(3-(((2-Aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride 4a5y Intermediate state of human kinesin Eg5 in complex with Ispinesib 4ap0 The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib 4aqv Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state. 4aqw Model of human kinesin-5 motor domain (1II6, 3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.5-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the rigor state. 4as7 Eg5 complex 1 4atx Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin 4b7b Eg5-3 4bbg Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol 4bn2 The crystal structure of kinesin-like protein KIF15 4bxn Eg5(WT) complex 4ck5 Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP state, based on cryo-electron microscopy experiment. 4ck6 Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP.AlFx state, based on cryo-electron microscopy experiment. 4ck7 Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in presence of adp.alfx (NECK-LINKER IN ITS DISCONNECTED CONFORMATION, based on cryo-electron microscopy experiment 4etp C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil 4frz Arabidopsis KCBP motor domain dimerized via regulatory domain 4gkr Structure of the C-terminal motor domain of Kar3 from Candida glabrata 4h1g Structure of Candida albicans Kar3 motor domain fused to maltose-binding protein 4hna Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN 4lnu 4LNU 4ozq 4OZQ 4ubf 4UBF 4uxo 4UXO 4uxp 4UXP 4uxr 4UXR 4uxs 4UXS 4uxt 4UXT 4uxy 4UXY 4uy0 4UY0 4y05 4Y05 4zca 4ZCA 4zhi 4ZHI 5gsy 5GSY 5gsz 5GSZ 5hnw 5HNW 5hnx 5HNX 5hny 5HNY 5hnz 5HNZ 5m5i 5M5I 5m5l 5M5L 5m5m 5M5M 5m5n 5M5N 5m5o 5M5O
- Links (links to other resources describing this domain)
PFAM kinesin BLOCKS KINESIN_MOTOR_DOMAIN1 INTERPRO IPR001752


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Posts Tagged Classic car
Cuba – A vintage car heaven or A car graveyard
Posted by hollatainment in travel on April 18, 2013
Spring has sprung and every now and then I see a vintage car getting an air bath with its proud owner driving leisurely down the street.
This post is to celebrate all old cars that have been given a new lease of life, especially the ones I saw in Havana, Cuba.
I want to believe that they are living their second life because their owners had no option but to hold on to them.
Enjoy America's gift to Cuba!
And there are the Russian cars…………..
5.555717 -0.196306


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Event Archive - Lust Life Jazz Band Plays The Bengal Lounge: Lust Life Jazz Band
Sat. March 5th 2016 @ The Bengal Lounge Victoria BC (No Minors)
7:30 - 10:30
Event CategoriesMusic: Funk / R&B, Jazz / Blues
Catch Lust Life Jazz Band at the Bengal Lounge in The Fairmont Empress Hotel for a great evening of cool jazz and funky stuff every Saturday night from 7:30 pm-10:30 pm. Featured musicians in The 2015 Victoria International Jazz Festival, Lust Life has been a staple of the Victoria music scene for years. The repertoire stems from the love of the jazz song form, the great American songbook and takes inspiration from jump jazz, blues, funk and swing.Sultry vocals, infectious grooves, and original improvisations create an exciting new concept in modern jazz. The style of Lust Life, truly defies classical description
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Lust Life Jazz Band (Jazz)
Featured musicians in The Victoria International JazzFest and many other events, Lust Life has been a staple of the Victoria BC and Vancouver Island music scene for many years. Frequently guest soloists join the band to offer their opinions in the language of jazz. The repertoire stems from the love of the jazz song form, the great American song... more info


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vet that took samples at Madison Retriever Club trial reported that 8 of 17 samples came back as carriers
How big is this problem??
vet that took samples at Madison Retriever Club trial reported that 8 of 17 samples came back as carriers
How big is this problem??
A lot of the dogs at Madison are sired by the same "suspected" carriers.
I would like to ask "lablady" how she knows about the sires of these dogs.
My dogs sire is EIC clear but both his 6 and 7 month old pups are carriers
Do you know the sire of these two dogs?
Please don't make statements like this unless you can state for a fact who the sires are.
As per my conversation today he said the first 17 that came back 8 were carriers.
that is all i know
I do not know how many he collected at the Madison Trial.
So much for this being a "results" thread.
Jeff Telander
Durham, NC
FC AFC CT Broad Reach Devil Made Me Doit CD "Sinner"
Broad Reach Smarty Pants
Forever in my heart
OTCh Broad Reach Diesel TD MH UDX2***
CH Broad Reach Gripper UD MH
OTCh R Labs Darth Wader TD JH
OTCh Teracroft Topaz TD JH
Thank you for posting Dusty's results here, Missy. I hope others with dogs of his caliber will do the same.
Proud to be a Dusty pup owner!
Marlana Smith
APR SHR TDK's Dusty Gunslinger JH - "Churchill"
CPR Max's Black Diamond Girl Scout JH - "Scout"
An ounce of prevention is worth a pound of cure.


text: Back Choline Other name(s) choline bitartrate, choline chloride, choline dihydrogen General description Choline is a water-soluble component of many important chemicals within the body. Although not all choline functions and interactions are known, it is believed that choline is necessary for normal liver and kidney function. Choline is also a component of the neurotransmitter acetylcholine, a chemical that passes messages between nerves, and between nerves and muscles. Choline is also the building block of lecithin and sphingomyelins. Lecithin is a major component of cell walls, plasma and lipoproteins. Sphingomyelin is the insulating material of brain and nerve tissue. Medically valid uses Most people obtain sufficient choline from their diet. Because deficiency occurs only under unusual circumstances, use of choline supplements is limited. Choline currently does not have a well-established use as a supplement in healthy individuals. Unsubstantiated claims Please note that this section reports on claims that have NOT yet been substantiated through scientific studies. Choline supplements have been suggested for the treatment of certain neurological disorders associated with the cholinergic system, but studies have demonstrated that oral supplements of choline do not affect brain metabolism. Choline is claimed to be useful in the treatment of: Tardive dyskinesia Huntington's chorea Tourette's syndrome Friedreich's ataxia Presenile dementia Fatty liver and cirrhosis In addition, choline supplements have been reported to reduce cholesterol, control mood swings, protect the liver from damage attributed to alcohol, decrease blood pressure, improve memory, and treat Alzheimer's disease. Choline is also claimed to increase athletic performance. Recommended intake The Food and Nutrition Board of the Institute of Medicine has established an Adequate Intake (AI) of choline as 550 milligrams (mg) for adult men and 425 mg for adult women. An average diet generally supplies these amounts of choline. Foods containing choline include egg yolks, soybean, wheat germ, peanuts, and liver. Although not yet demonstrated in humans, choline deficiency in animals may lead to abnormal liver function and kidney damage. Choline-associated liver dysfunction has led to liver cancer in laboratory animals. People being fed intravenously may develop low serum levels of choline and require choline supplements. Side effects, toxicity and interactions Choline in normal doses may cause stomachache, diarrhea or loose stools. Large quantities (~20 g) have been associated with dizziness, hypotension, fishy body odor, depression, and electrocardiographic abnormalities. Choline may cause depression in some patients. Choline should not be used by people with bipolar disorder. Women who are pregnant or breastfeeding should consult a physician before taking any dietary supplements. There are no known interactions between choline and any food or drug. Low serum folate levels (insufficient folic acid) may increase the requirements for choline. Additional information Click here for a list of reputable websites with general information on nutrition.


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My mother still smiles out at me from a small black-and-white photo on my bookshelf. In the picture, she is a prim young woman in a crisp white shirt and smart pinafore. You can just make out a set of wings—her first—pinned to her chest. It is 1939, and she is only 17 years old. That gleam of silver over her heart and her grand smile say it all: She had achieved her dream. She could fly.
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My mother, Geraldine "Jerry" Hardman Jordan, was one of the Women Airforce Service Pilots of World War II. She knew she wanted to be a pilot from the time she was five years old, and she could pinpoint the moment she made that decision: May 22, 1927. On that day, she was at her grandparents' farm outside the tiny town of Ontario, Oregon. The farmhouse had no radio or telephone; when major news broke, a neighbor simply saddled up his horse and rode from farm to farm to spread the word. The news he brought that day: Charles Lindbergh had flown across the Atlantic and landed in France. As my mother would tell us again and again, when the neighbor rode away, she looked up and said, "That's what I want to do."
With encouragement from her father and brother, Mom began flying when she was 15. Her uncle, a larger-than-life character named Casey Jones, was a pilot; he ran the small airport in Ontario, and let Mom work at the field. Her first paycheck went to buy a pair of jodhpurs and riding boots, so she could be decked out like her hero, Lindbergh, but after that, every dime of her pay went toward flight time. She did all the airport scut work imaginable: sweeping the enormous hangar, washing airplanes, and—in a demonstration of true dedication—cleaning the inside of Casey's airplane after he'd taken passengers with fragile stomachs up for their first flights. In return, Casey gave her flying lessons. "I took my time however I could," she told me. "Fifteen minutes here, 20 minutes there—whatever I could scrounge up the money for."
Casey had spent some time barnstorming and had a surplus Curtiss Jenny that he used to teach her the basics. "We'd pick out a straight line on the ground, like a road, and fly back and forth making S turns across the road," my mother explained. "Our favorite entertainment was to fly over the mountains of Idaho and look for landing spots." On one of these trips, her pocket change hadn't bought quite enough to fill the tank, and she and Casey had to make an unscheduled landing in a farmer's field. She told me about chasing away cows, eager to lick the Jenny's fabric skin, while Casey hiked to the nearest town for gas.
In 1939, the University of Nevada at Reno was granted 20 slots for Civilian Pilot Training Program (CPTP) trainees. Ostensibly established to increase general aviation opportunities, the unspoken message of the CPTP was clear: As conditions deteriorated in Europe, the country needed a pool of well-trained pilots ready to take on military duties. My mother, who had graduated high school early, was working as secretary to the university president. Nineteen young men came forward for the training at the school that year, leaving one slot open, which Mom took. The program provided a 72-hour ground school and 35 to 50 hours of flight instruction. My mother earned her pilot's license that year, but after war was declared in 1941, pilots had to prove their identity to get a wartime aviator's ID. She couldn't produce a birth certificate, and struggled for a year to get authorized to fly. At the same time, efforts were under way in Washington, D.C., to put America's female pilots to work for the war effort.
Nancy Harkness Love and Jacqueline Cochran had both submitted plans to use female pilots in non-combat missions. Love established the Women's Auxiliary Ferrying Squadron (WAFS) with the support of Colonel William H. Tunner, commander of the Army Air Forces Air Transport Command. While Love oversaw the WAFS out of New Castle Army Air Base in Delaware, Cochran set up the 319th Women's Flying Training Detachment at the Houston Municipal Airport in Texas. By mid-1943, the two groups were merged into the WASP, training at Avenger Field in Sweetwater, Texas. Eventually, 25,000 women would apply for WASP training. Just over 1,800 applicants were accepted; only 1,074 would complete the program.
In assembling the WASP program, Cochran and her staff scoured the records of the Civil Aeronautics Administration to find female aviators to participate. They discovered 2,733 licensed U.S. female pilots in the files, and sent them telegrams inviting them to apply for the WASP program.
Mom was assigned to Class 43-W-5, the fifth WASP training class and the first group to go through all of its training in Sweetwater. Arriving there, the women discovered the military was ill-prepared to accommodate female aviators. The WASPs were issued men's surplus mechanics' overalls—in sizes 44 and up—which the women quickly dubbed "zoot suits." One of my favorite photos of my mother is her in her baggy zoot suit, soaking wet and grinning like crazy, after going through an Avenger Field ritual: a dunk in the field's wishing well to celebrate a successful solo flight.
WASPs went through 22 1/2 weeks of training as rigorous as the training male Army Air Forces cadets received, but the women skipped gunnery and formation flying. Simply surviving training could be risky: 11 women died before reaching graduation. My mother told stories of near disaster, such as climbing into airplanes that were sometimes missing pieces of equipment here and there. Once, during a posting to New Castle Army Air Base, she tried to land an AT-6 at night. The whole flight had been beset by mechanical problems, and, on approach, neither my mother nor the tower could tell if the landing gear was down. Mom described flying that Texan in circles over the Atlantic Ocean for more than an hour to burn excess fuel. She was terrified upon landing, but to everyone's relief, the gear was locked down and all was well.
Although the work carried significant risks, that time in my mother's life created some of her most treasured memories. When she talked about her WASP days, she always said that she would not have traded the experience for anything. "I just loved it," she would say. "If I had to pay them for the privilege, I still would have done it." She talked not just about her love of flying but also about the satisfaction of carrying out a patriotic duty.


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This is not an offer for credit and should be used for estimation purposes only based on the information you provided. You should not base your decision on this estimate alone. Title, registration, tax and other fees, and personal circumstances such as employment status and personal credit history, were not considered in the calculations.
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Front - 100/90-19
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Front - 41 mm telescopic fork; 5.5 in. travel
Rear - Single shock, adjustable preload; 3.4 in. travel


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I've not blogged recently on the Pompey basket case. Not because there wasn't much happening, but rather because there has been almost too much happening to stop and take a coherent view. In fact, the last time I posted was back in March 2011, when I commented "Portsmouth City Football Club Ltd. is dead – long live Portsmouth Football Club (2010) Ltd.!" (1), and it reads today like some historical piece, and at least a tad ironic to boot – the tagline was "Onward and upward at Portsmouth?"
The announcement that a conditional sale to the Pompey Supporters Trust has been agreed (2) brings at least some sort of turning point.
That the alternative bid from Balram Chainrai was turned down by the Administrator can only be good news – just how many times can the same person 'save' a club? Trevor Birch's choice may or may not have been influenced by the blogs of Micah Hall (3), but certainly the lack of response to the questions Micah posed to Tavistock Communications, Portpin's PR company, spoke volumes. Micah's digging deserves an award, and shows how far a fan can go in the bigger picture of financial decision-making.
The fly in the ointment of the sale is, of course, the issue of the value that Chainrai is trying to place on Fratton Park. Unless he finally decides to bow out gracefully, accepting that he made a very bad business call, the matter will go to court. With independent valuations at a much lower level, the Trust stands a very good chance of getting the desired result.
There is also the matter of a potential further ten points deduction on coming out of Administration. Here I am less optimistic. I fear it will be yet more evidence that the deduction of points is an entirely dysfunctional sanction, but let's not burn our bridges before we come to them.
All-in-all, there does finally seem to be a light at the end of the tunnel, and this hopefully will prove a turning point in the club's miserable fortunes.
In the bigger picture, it may well prove to be a turning point in the road to fan ownership of clubs. It does need to be seen though as one of many turning points, as I'm sure Brentford. Chester, Exeter Wrexham, and Wimbledon fans, and that's not a definitive list, would be quick to point out. It's significance will depend on how well the hybrid model involving High Net Worth Individuals will work in practice. If it does work, it will doubtless encourage the Supporters Trusts at bigger clubs such as Liverpool, Manchester United and Newcastle.
As a member of the Pompey Supporters Trust, I feel considerably more confident regarding the future than I have for a very long time. I've even put a bottle of bubbly in the fridge, but I'll not actually open it though until Fratton Park is in the fans' hands. The only certainty is the debt of gratitude Pompey fans owe to the PST Board. Let's show our gratitude by uniting behind them.


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Say hi to other HRF members and let us know where you are and what your interests are.
Graduation From Pre-Noob to...
Today, 08:29
Please post link to the news articles for discussion, not the actual article for copyright reasons. Thanks.
Mon 5th Dec 2016, 21:32
Show off and tell us about your Ham Radio shack, QSL Cards, yourself, even your personal websites, & let us know about your club events.
Tue 19th May 2020, 01:35
Clubs are the "heart" of amateur radio, so this discussion forum is for individuals to discuss amateur radio clubs, to exchange ideas, on how to run a club, how to set up club programs & more.
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Think we are missing a Forum, problem with site, are we missing something, or other problem with site?? Post here and we can discuss.
Wed 24th Jun 2020, 08:01


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Roland Emmerich has pushed bad science to its limit before, most notably with the amazing 2012. But for his upcoming movie Singularity, he's actually enlisting the help of Ray Kurzweil, author of The Singularity is Near, to help him revise the script. On the one hand, this means the movie will accurately reflect Kurzweil's theories about a magical transformation in which everything becomes awesome thanks to A.I. and other breakthroughs. On the other hand... will the result actually be more unrealistic than 2012?
Variety reports that Kurzweil is joining Emmerich and his cowriter Harald Kloser to revise the script for Singularity — and pre-production on the movie has been put on hold while the three men work out the kinks in the script. Reading between the lines, it sounds as though Sony, the studio producing the film, was unhappy with the current script draft and sent Emmerich back to the drawing board. Sony remains committed to the project, after how much money Emmerich made them with 2012, and it's still probably going to make its May 2013 target release date.
And Variety gives us our best synopsis of Singularity so far:
Set 50 years in the future, "Singularity" follows a nanotechnology pioneer who uses a dangerous new procedure to save his badly injured son, Adam, whose consciousness is transferred into a swarm of nanobots that take his physical form, giving him all sorts of powers. Protag ends up on the run from an evil corporation that developed the technology.


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Abrasives are generally minerals used to finish workpieces through rubbing. They are used in various forms in grinding, homing, lapping, finishing, polishing, blasting, abrading or smoothing.
Large and small range of products that are used to generate, transmit or distribute electrical power from one place to another place, including generator, motor, transformer, transmission and distribution cable, protective devices such as circuit breakers, fuses, relays, power conditioner and converters, switches and accessories. It has multifarious usage in departments of technology, science, construction, home appliances, automation, giant laboratories, telecommunication and defense sectors.
An adhesive is any substance applied to the surfaces of materials that binds them together and resists separation. Sealant material used for sealing something so as to make it airtight or watertight.
Work holding and positioning components allow for faster speeds and feeds within the manufacturing process. Their modular and economical replaceable wear surfaces extend the life of expensive jigs, fixtures, jaws, and clamping mechanisms.
HVAC is the technology of indoor and vehicular environmental comfort. Its goal is to provide thermal comfort and acceptable indoor air quality. HVAC system design is a subdiscipline of mechanical engineering, based on the principles of thermodynamics, fluid mechanics, and heat transfer. Refrigeration is a process of moving heat from one location to another in controlled conditions.
Battery is a device consisting of one or more electrochemical cells with external connections provided to power electrical devices such as flashlights, smartphones, electric cars etc. and its accessories are like battery adapter, Chargers ,clips, connector etc.
In its most basic form, a chemical is an element, in that it has a specific molecular composition and may be produced by or used during a natural chemical process. Includes automotive chemicals, cleaners, detergents, floor, surface & upholstery chemicals and metalworking chemicals.
Cutting tools are tools designed to cut material or objects in the processes like drilling, turning, cutting, milling, grinding, sawing, threading, shredding, brushing. Metalworking Machinery & Equipments are used to cut, shape, and assemble components that are made of different types of metal, including drill presses, milling machines, saws, punch press machines, tapping machines and more.
Electronics, IT & Telecommunications are amongst the most prominent areas of technology in the world. Products are used in many industries such as entertainment, IT & home décor, networking, multimedia and automation to name a few. These products are intended for everyday use in households, by professionals, individuals, etc. for fulfilment of their daily needs whether at work or home. Products include televisions, cameras, cocks, audio devices, smart phones, tablets, and many other goods.
A quantity of various multipurpose items of wearing apparel providing general protection to the wearer at workplace for different environments.
A fastener is a hardware device that mechanically joins or affixes two or more objects together.
A tool or parts which is used for maintenance or repair in automotives. All of which can be made use of, while the automobile suffers any internal failure or problem. These will not only provide care but also enhance the aesthetics of the automotives. Products ranging from car body covers to automotive lubricants, coolants, engine oil, parking sensors, additives and transmission lubricants, vehicle lifting tools, mechanical gears and stands etc.
Hand tools are the basic manual equipment used to carry out a variety of tasks, which require force. Unlike the mechanical devices, these tools need manual efforts to be operated and are considered less hazardous than automated appliances. The most prominent types of hand tools listed are wrenches, screwdrivers, nutdrivers, punches, pullers, cutters, crimpers, allen keys, hammers micrometers, calipers & gages, measuring & layout tools, marking tools, inspection & retrieving Tools etc.
The generic term dealing with physical items as distinguished from its capability or function such as equipment, tools, implements, instruments, devices, sets, fittings, trimmings, assemblies, subassemblies, components, and parts.
A hose is a flexible hollow tube designed to carry fluids from one location to another. A pipe or tube is a tubular section or hollow cylinder used to convey substances which can flow — liquids and gases (fluids), slurries, powders and masses of small solids. Products includes hoses, tubes, valves, fittings, piping air and liquid distribution systems and other pneumatic and hydraulic products.
Hydraulics is the branch of science and technology concerned with the conveyance of liquids through pipes and channels, especially as a source of mechanical force or control.
Janitorial and maintenance includes all you need to keep every inch of your facility clean and well-maintained-from the cleaning tools and equipment to do the job and the carts and cabinets to store them in, to the ladders, lifts and platforms to reach the heights.
Lab Supplies are the type of equipment found in a building or room equipped for conducting scientific research or for teaching practical science, as for carrying out scientific experiments, etc
Lawn, Garden & Outdoor Equipment help you make a space ready for planting (shovels and spades), clearing out large limbs and branches (pickaxes and mattocks) and helps to haul off debris and limbs (wheelbarrows).
Lighting products provide light for better visibility.
Lubricants and coolants are substances introduced to, reduce friction between surfaces in mutual contact, which ultimately reduces the heat generated when the surfaces move. .
Material handling involves short-distance movement within the confines of a building or between a building and a transportation vehicle.Rigging is the apparatus through which the force of the wind is used to propel sailboats and sailing ships forward.Storage products are commercial cabinets and industrial cabinets with high-density storage and extra heavy-duty welded construction with customizable compartments and shelves.
Office Products are Stationery or consumables required for the everyday business like paper clips, scissors and file folders to binders, staplers, printers etc. Furnitures are the movable articles like tables, chairs, desks or cabinets required for use, storage or ornament in a house, office, or the like. Food service products required for preparation, serving of the food, includes from cookwares, cutleries, kitchen utensils etc.
Paint is a liquid mixture, usually of a solid pigment in a liquid vehicle which forms a thin dry film when applied on a surface. It is most commonly used to protect, color, or provide texture to objects. An paint application tools and equipments are useful for rapidly painting large flat surfaces efficiently.
The system of fittings, valves and valve accessories, pipe and pipe accessories, hose and hose products, flanges and gaskets, restroom and plumbing fixtures, repair and replacement parts, tools, cleaning equipment and pumps and accessories for the water supply, heating, and sanitation in a building.
Pneumatics is concerned with the mechanical properties of gases
Portable lighting and flashlights help illuminate dimly lit work spaces be it the basement, the garage or even outside after sunset. Hands-free work lights help you get the job done by hanging, standing or even coiling around the location you'll be working in. Flashlights are the portable hand held devices used for similar applications.
Power generation of electrical power is a process whereby energy is transformed into an electrical form and transmission is the bulk transfer of electrical energy from generating power plants to electrical substations located near demand centers.
A pump is a device that moves fluids, liquids, gases or sometimes slurries by mechanical action by using energy sources, including manual operation, electricity, engines or wind power. Filtration is a mechanical or physical operation which is used for the separation of solids from fluids by interposing a medium through which only the fluid can pass.
A Raw Material also known as a feedstock or most correctly unprocessed material, is a basic material that is used to produce goods, finished products, energy, or intermediate materials which are feedstock for future finished products.
Packaging tapes are strips of material, typically used to hold or fasten something. Can be used for many different packing applications. Some of them includes hot melt tape; box sealing and carton sealing tapes; adhesive packing list envelopes; clear acrylic, polypropylene and paper tape; matting tape and lithographers tape; biohazard warning tape, lane marker dots and arrows and more
Test instruments help to isolate problems, maintain vital processes and solve problems before they interrupt workflow or cause hazards in the facility.
It s the process of combining two materials, usually metal, by heating them until both ends become molten or Is a method of joining two pieces of metal by melting them together with another metal to form a strong bond
Power tool is a tool that is actuated by an additional power source and mechanism other than the solely manual labour used with hand tools.
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