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Original source here
YESS!!!! This time its really here! Atlus has finally stepped up thier shit and started working on persona 5. Hell yes, things cant get any better than this! And thats not all, theres more! Atlus is currently working on three games, all of which spell AWESOMENESS for any persona fan out there. All of this has been revealed via a famitsu article.
|Persona 4 seriously can't get any more awesome that it already is..
So we can assume P4P to be as or even more awesome than P3P, thats what I think. The original persona 4 was better than the original persona 3 IMO. So far, as far as revealed info goes, theres a new character called mary in the vita version of persona 4, how does that affect us?.....Honestly, I dunno, but if its brings forth some new story elements, I'm all for it. And, HOPEFULLY, we get a female protagonist for this one too, so we get another different story perspective once again. That would be friggin' badass, I assure you.
|Persona 4 vs Persona 3? Damn, imagine the possibilities!
Whats more, we have arc system works, the genuises behind the blazblue and guilty gear games, working on this with atlus. Hopefully this won't make the game suck and they will help turn this game into one of their many masterpieces. Theres really nothing else for me to comment on this, hoping to see how this shapes out!
|Lets hope its awesome, seriously.
Here we are...the main attraction that EVERYONE has been waiting for. PERSONA 5!! Well, theres not much I can say here, since nothing has been revealed AT ALL, but we know that shoji meguro and crew behind persona 4 will be working on this...thats reasurring enough. We will be getting something badass, thats for sure! And this better be for the PS3/XBOX360, not the vita or some shit, persona 5 deserves the BEST, and I literally mean the best, it has to be something of the persona 3/4 calibur, NOTHING LESS. Altough, knowing them, things will probably go well, and they will cook up a fantastic game. I have faith in atlus.
Too much....seriously. Theres far too much goodness packed in one day. Thank you atlus for these 3 coming projects, and I'm sure you can pull each and every one of them off successfully. Cheers! Now I just have to buy catherine!


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Add this event to your Google, iCal, or Outlook calendar by clicking one of the links below. Registration is still required.
Bear Bags and Backcountry Food Storage Workshop
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$15 for REI Members
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- Group size 6 people
- Instructor REI Specialist
Are you ready to travel in bear country? Join REI's expert guides to learn the basics of bear canisters and bear bags, and when and where to use them. You'll get a hands-on chance to practice bear bag hanging skills, and learn bear awareness to keep your food (and your campsite) bear free. No bears nearby? These skills will protect your food from many other small creatures, and ensure you don't wake up with any unwanted, furry visitors. No prior experience necessary.

subset: commoncrawl


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Court 6mm wedding band in platinum
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i would like to do the navigation from a website using blender.
the navigation (blenderfile) is in one frame and the
content in another. to change the content i use a javascript-
function, which is called by a message-actuator in the blenderfile.
this works exactly 15 times fine and on the 16th the Internet Explorer
crashes. i tried it on three different Win2000 workstations with IE 5.0 and
6.0 and it is always the same thing.
The errormessage is "R6025 - pure virtual function call".
Does anybody know, how to fix it or a workaround ?????
web-plugin bug ???
Game Engine, Players & Web Plug-in, Virtual Reality, support for other engines
Moderators: jesterKing, stiv
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2 posts • Page 1 of 1
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Dunkin Donuts Blackface Posters Criticized as 'Racist'; Company Issues Apology (PHOTO, VIDEO)
Dunkin' Donuts' new blackface advertising campaign has been widely criticized and has forced the company into issuing an apology for their "insensitivity."
The advertising campaign took place in Thailand and featured a woman in blackface makeup to promote a new chocolate flavored drink.
However, the campaign came under fire on Friday when Human Rights Watch labeled the adverts "bizarre and racist."
Quickly, Dunkin's chief executive in Thailand sought to defend the campaign, but as criticism continued to spread, the U.S. headquarters moved to issue a formal apology.
Dunkin' Donuts said in a tweet posted on its official U.S. Twitter page: "We are working with our Thailand franchisee to immediately pull the ad. DD recognizes the insensitivity of this spot."
The campaign was in fact launched last month to promote a new "Charcoal Donut" range, and shows a woman smiling covered in black makeup, as well as bright pink lipstick. The poster was launched with a slogan in Thai reading, "Break every rule of deliciousness."
Many critics have slammed the advertising campaign as being reminiscent of the Minstrel show, which was an American entertainment consisting of comic skits, variety acts, dancing, and music, performed by white people in blackface in the 19th and 20th centuries.
The Minstrel show was later criticized for lampooning black people as dim-witted, lazy, buffoonish, superstitious, happy-go-lucky, and musical.
After noticing the advertising poster for the Thai branches of Dunkin' Donuts, Human Rights Watch, based in New York, released the following statement through Phil Robertson, the deputy Asia director for the organization: "It's both bizarre and racist that Dunkin' Donuts thinks that it must color a woman's skin black and accentuate her lips with bright pink lipstick to sell a chocolate doughnut. Dunkin' Donuts should immediately withdraw this ad, publicly apologize to those it's offended and ensure this never happens again."
Following the initial criticism the company's chief executive in Thailand dismissed the criticism as "paranoid American thinking."
CEO Nadim Salhani said in a telephone interview: "It's absolutely ridiculous. We're not allowed to use black to promote our doughnuts? I don't get it. What's the big fuss? What if the product was white and I painted someone white, would that be racist?" according to The Associated Press.
Salhani did confirm that the Thai franchise of Dunkin' Donuts operates independently of the American operation. He claims doughnut sales have increased 50 percent since the campaign was launched two weeks ago.


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B.J. Hoeptner Evans
Manager, Communications
Phone: (719) 228-6800
E-Mail: firstname.lastname@example.com
@USA_Volleyball - USAV Facebook
COLORADO SPRINGS, Colo. (Dec. 12, 2012) – Outside hitter Matt Anderson (West Seneca, N.Y.) has been named the USA Volleyball Indoor Male Athlete of the Year for 2012, while setter Donald Suxho (Korce, Albania) has been selected as USA Volleyball's Most Improved Player in the indoor male athlete category.
At 25, Anderson was the youngest player on the U.S. Men's Olympic Volleyball Team. He finished the 2012 season as the team's leading scorer with 393 points on a team-leading 326 kills, 42 blocks and 25 aces (second highest on team). Anderson started 96 out of the 97 sets for the U.S. Men. His kill percent was 50.7 and his hitting efficiency was .440.
"My success this season with the National Team came from the realization of the trust my teammates and coaches had in me," Anderson said via e-mail from Russia where he is playing for Zenit Kazan in the Super League. "In training we created an atmosphere of the best volleyball and it was tough to differentiate between training and big-time matches."
Anderson started all 21 sets of the Olympic Games in London and was the team's leading scorer with 81 points on 69 kills (.390 hitting efficiency), six aces and six blocks. His tournament best was 18 points (16 attacks, one block and one ace) scored in 3-2, pool play loss to Russia. The U.S. Men finished fifth in London.
"The highlight of my 2012 season was being a part of the 2012 Olympic Games," Anderson said. "There is no words to describe the honor I received being able to walk with the team in Opening Ceremonies, and then to compete on the world's biggest stage for my country, the USA. The low point is leaving the Olympics knowing we could have accomplished more as a team."
Anderson played in all 60 FIVB World League sets in which the U.S. Men competed and was the team's leading scorer. He finished with 248 points on a team-leading 205 kills, 32 blocks and 11 aces. He was fifth among all World League scorers at the end of pool play. His tournament high was 21 points scored against Korea on June 16.
Anderson was named "Best Spiker" at the NORCECA Men's Continental Olympic Qualification Tournament on May 7-12 in Long Beach, Calif., as the U.S. Men qualified for the Olympic Games. He played in 15 out of 16 sets and was the team's leading scorer, finishing with 64 points on 52 kills, four blocks, and eight aces. His hitting efficiency was .585 and he scored a tournament-high 24 points against Cuba.
"My sights are already set on (the Olympic Games in) Rio 2016," Anderson said. "If I'm lucky enough to make that squad, I don't want to go home from those Games without a medal, hopefully gold."
Suxho, 36, went into the 2012 season not knowing for sure if he would be the team's starting setter, as he had to battle Brian Thornton (San Clemente, Calif.) and Kevin Hansen (Newport Beach, Calif.) for the slot. Suxho ended up playing in 92 of 115 sets in which the U.S. Men competed. He helped the team to a season kill percentage of 45.4 and a hitting efficiency of .375. He also finished the season with 46 points on 18 kills, 24 blocks and four aces. He was credited with 128 digs (1.39 per set) and 705 running sets (7.67 per set).
"I am extremely thankful to the USA Volleyball organization, the USA coaching staff and the medical staff for training and helping me," Suxho said via e-mail from Argentina where he is playing for Drean Bolívar. "I also want to thank my teammates for trusting me."
Suxho finished second among all setters at the 2012 Olympic Games in London where he was credited with 213 running sets (10.65 per set). He started 20 out of 21 sets and scored 10 points on three kills, six blocks and one ace.
"The highlight of my season was winning our group at the Olympics," Suxho said. "The low point was losing to Italy in the quarterfinals. It was like a stab in the heart."
Suxho played in 57 out of 60 FIVB World League sets for the U.S. Men, scoring 29 points on 14 kills and 15 blocks, including highs of five points against France in France (four kills, one block) and against France in Dallas (one kill, four blocks). He finished first among all setters in pool play with 331 running sets (5.81 per set) and finished second among all setters in the Final Round with 74 running sets (5.29 per set).
He started 15 out of 16 sets for the U.S. Men at the NORCECA Continental Olympic Qualification Tournament. He finished with seven points on one kills, three blocks and three aces and was credited with 87 running sets (5.44 per set).
"My goals are to continue to improve my game, stay healthy and win gold in Rio," Suxho said.


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As with most things, I'm sure this concept has been tried before - I just haven't come across editors that use what I've termed 'Virtual Formatting'. The principle is that there's a floating left-margin that simulates the effect of the padding space/tab characters that are conventionally inserted by the developer or the editor itself to format the code. The editor continously parses code (even when commented-out) as you type and calculates the required indent based on the context where each line-feed is found
I'm developing this idea working specifically with an XML editor as XML has some peculiar problems with formatting characters and it tends to be heavily nested, however I believe many of the principles still hold for conventional code.
Have you experience coding with such a tool or do you have a view on whether it would help or hinder? Would it cause problems with version-control systems? (it detects and strips out all existing padding characters)
Unless you've tried it, the behavior of such a tool is hard to describe, it looks conventional until you actually start editing. I've put up a screencast video showing a prototype in action which demonstrates editing XML, changing it's hierarchy and doing drag/drop and copy and paste operations, and then how formatting is broken/fixed when invalid characters are typed.
Edit All answers/comments have so far been negative - so to attempt to redress balance, some benefits of virtual-formatting to think about:
- No more debates on formatting standards, just place line-feeds where that conforms to your chosen/mandated convention
- Where space is at a premium (in a book/blog/documentation) you can word-wrap but still getting perfect indentation
- Each code-block can have a 'mouse-handle' immediately adjacent to where it starts, not squeezed into the screen edge - click this to select the whole block or inner-block
- Drag, drop and forget - becomes viable for the first time
- No time spent reformatting other peoples code
- No incorrectly formatted code (in the sense that there is none - just the rendering)
- Using Backspace instead of Ctrl+Backspace keeps your fingers on the keyboard guide-keys
- Flexible rendering - adapt rendered formatting to your environment, anyone tried reading code on a mobile phone/small-screen tablet?
- Consider that there are roughly 25% fewer editable characters (in a sample XSLT), doesn't that have efficiency benefits?
Edit - Conclusions so far
Developers have established tools and working methods that efficiently overcome most of the disadvantages inherent in the use of padding characters used for indentation.
There is concern that removal of formatting characters will detrimentally affect some differencing tools.
Developers want the flexibility to 'fine-tune' formatting in such a way that automated rendering could not handle.
The removal of leading spaces/tabs means that a 'code-aware' tool capable of code-formatting is needed to review such code efficiently - a plain-text editor would show no formatting.
Those that feel there may be some hypothetical benefits (to virtual-indentation), have a view that the disadvantages outweigh those potential benefits - conclusively.
Edit - Verdict
The perception of the obstacles and few (if any) benefits is such that it would be unwise for me, as a sole-developer, to pursue this space-free editing concept for general languages. For XML/XSLT, however (because of its special treatment of whitespace), there seems to be some agreement of potential at least.
Edit - Product Shipped
In spite of the generally negative sentiment found here, I went ahead and shipped the editor. I made a free version in the hope it would bring criticism in the form of more concrete issues, based on real experience. Somewhat frustratingly, there have been no complaints so far (in fact barely any feedback considering download volume). I'd like to think this was because users adjusted to the idea so well that they see this as a 'so what?' kind of feature - but there's no way of telling...


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STEROIDz - Grammy Night [Unsigned Hype]
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I had been to Masbate port twice in recent days in this month of July of 2017. The first one was when my ship Super Shuttle RORO 3 of Asian Marine Transport Corporation (AMTC) was on the way to Batangas and dropped anchor in Masbate first. The second was when I took the route via Pilar and Masbate ports on the way back to Cebu. Those two visits afforded me a chance to compare and weigh developments in Masbate port since last January of 2017 when I was also able to visit the port.
Masbate port
The first notable thing is all works in expanding Masbate port has already been completed. The lineal distance of the port is a little longer now. On the other hand, talking of infrastructure, the Masbate port terminal building deteriorated in the same span of time as it is no longer air-conditioned and yet the dear terminal fee which is more expensive than the much better Cebu and Batangas ports remained the same when Masbate port does not even have shuttle buses and does not really have the capacity to take in all the passengers of the buses. And so it copied the Batangas port model which means bus passengers have to go down when the bus enters the port in order for them to pay the terminal fee and then board the bus again or walk to the ferry. The former is the preferred mode now.
Another new thing is Masbate port has an X-ray machine now for the baggage but it is not operational yet. Another useless piece of equipment just to justify the terminal fee and to have another reason for "cattle-herding" the passengers. It seems what is good enough for the buses is not good enough for PPA (Philippine Ports Authority), security-wise, because buses don't bother checking the baggage of the passengers because they know the chance of them being victims of terrorist attacks is next to nil, at least in Bicol. And I think if one asks the ferries they will say they are not bothered if there is no X-ray machine. The buses and the ferries do not have the ISPS thinking that all passengers are possible terrorists. Actually that is simply ridiculous and is just the product of "praning" minds.
One more notable thing is that the passenger motor bancas are now practically gone from Masbate port and they have already transferred to the municipal port of Masbate near the public market and the bus/van terminal because of the high passenger terminal fee being charged by the port when passengers have no actual need for the terminal as they go direct to their vessels. Actually, last January I saw a terminal building (it was named as a community fish landing center) being built in Masbate municipal port and I saw that it is already finished when I went to the bus and van terminal.
The problem now in Masbate municipal port is congestion, I was told, especially in the rush hours of the morning and the early afternoon. The boat landing areas there are actually the facility being used by the so-many small passenger motor bancas and motor launches headed to the different barrios across Masbate Bay. Add to that that that is also the docking area of the passenger motor bancas to barrios just outside Masbate Bay and up to Baleno town. Now the bigger motor bancas to Ticao island, Pilar port and Burias island are also lumped there now. That also includes a few cargo motor boats that were once passenger motor boats.
Actually, some small motor launch operators also built docking areas just beyond the northern end of Masbate port. I was told these transfers were the reaction to the terminal fee that costs P30. A terminal fee of that amount for a P10 boat fare? So right now just a very few motor bancas use Masbate port. One effect is congestion of the port was gone in one stroke. So I wonder now if there was any need to lengthen the port after all. Maybe they could have just donated the construction materials to the boat landing areas at the end of the port. The surface there is still dried muck which is obviously undulating and slippery. Well, if the funds were really meant to benefit the public.
A makeshift boat landing area adjacent Masbate port
Regarding steel-hulled ferries, the competition in Masbate port is heating up and truck volume was obviously bigger than last January. Not in the buses though as July is already part of the lean months. Sta. Clara Shipping Corporation fielded their Cargo RORO LCT there, the LCT Aldain Dowey which was identified in PSSS (Philippine Ship Spotters Society) as the former LCT Ongpin. So now they have a total of three ferries in Masbate and I was told in summer Sta. Clara Shipping even fielded a fourth ferry. Their LCT is of the same length as their Jack Daniel and Anthon Raphael, their two ROPAXes there which are the best in the fleets of Sta. Clara Shipping Corporation and sister company Penafrancia Shipping Corporation (this is before the fielding of the former Tamataka Maru ships from Japan).
Their LCT is the first to leave at noon and in the afternoon they are the only ferry departures from Masbate at 2pm and 4pm. Their three ferries are the biggest in Masbate because what their competitors have are only basic, short-distance ferry-ROROs because they use the shallow Pilar port whose depth cannot handle bigger ferries. By the way in terms of rolling cargo traffic the Pio Duran route now of Sta. Clara Shipping and Penafrancia Shipping is the favorite now since Pio Duran in Albay is nearer to Manila than Pilar of Sorsogon while the rolling cargo rate is just about the same.
With the exception of the ROROBus which is related to Montenegro Shipping Lines Inc. practically all the other buses to Masbate are handled by Sta. Clara Shipping Corp. and Penafrancia Shipping Corp. as the third operator Denica Lines, a Pilar native does not load buses. Loading buses from Luzon meant extending discounts, rebates, free tickets and free meals and Denica Lines does not play that game because they say they have their share of rolling cargo too. And I saw that when we left left Pilar port aboard their Marina Empress at 3am and the car deck was full. From Masbate port their three ROROs Odyssey, Regina Calixta-II and Marina Empress all left full. Denica Lines has already bought the Regina Calixta–II of Regina Shipping Lines (RSL) of Catanduanes and so they have three ROROs also now while Montenegro Shipping Lines Inc. (MSLI) is down to two ROROs from three. Maybe because it is lean months now and maybe they have one undergoing refitting in a shipyard.
If we assume that Montenegro Lines has a third RORO in Masbate then a total of 8 ROROs make a daily crossing now to Luzon plus there is a Cargo RORO LCT for a total capacity of about 100 truck/bus units (of course, since there are smaller vehicles mixed in, the actual total is higher). Many of these come from as far as Cebu island. Buses will be at least a fourth of that total. One will wonder why there is such a large number of people on the move when within Masbate island there are not that many number of buses although there is a significant number of commuter vans.
Montenegro Lines have three fastcrafts and a catamaran in Masbate including their newest and fastest, the City of Angeles which is a catamaran. They also have there one of their biggest fastcrafts, the City of Masbate. Their future rival, the two fastcrafts of Denica Lines are still not ready and are still being refitted in Pilar port. Meanwhile, I wonder if the Masbate-Pilar motor bancas are already in terminal decline. There are just so many ROROs and High Speed Crafts. Although the motor bancas are faster than the basic, short-distance ferry-ROROs, they are noisier. They might be noisy, however, but still they are better than the "Stairs Class" of Montenegro Lines.
But in trucks and buses Sta. Clara and Penafrancia are already beating Montenegro Lines by about 3:1. Denica Lines could also be level now with Montenegro Lines in trucks and buses. By the way, sedans, SUVs, AUVs are not that many in the Masbate crossing to Pilar and Pio Duran and jeeps are practically unknown.
However, there is a rumor in Masbate port that a new player will come and serve the Masbate-Pio Duran route and it seems it is not Medallion Transport which was gone from the route after their Lady of Carmel sank in 2013 off Burias island. It remains to be seen if this rumor will come true.
The Super Shuttle RORO 3 of AMTC is also back in Masbate port and it connects to Batangas and Cebu plus Cagayan de Oro but their schedule is irregular as in there are no definite day for arrivals and departures as it is more of a container carrier now. There are also still a few motor bancas to Bulan when where before that was the dominant route to Bicol from Masbate.
There are also off-hours docking now in Masbate port as Denica Lines has an early evening departure from Pilar. To the credit of Masbate port they let the passengers stay in the port terminal as the arrival of that is midnight and there is still no transportation to the towns outside Masbate City (and that gave me an idea). And Sta. Clara Shipping sends back its ship from Pio Duran if there are a lot of shut-outs (vehicles left unloaded in port) and that becomes another off-hours docking. That was the reason why they fielded their LCT because shut-out were already happening frequently (I saw that last January when one Mega Bus cannot be accommodated and they asked passengers of that to get down the ship and it was an event not good to look at — I pitied the passengers).
Masbate port is changing. Traffic is obviously up and I think the port will only get more important in the future when more traffic will shift to it from San Bernardino Strait if the rates become lower. Maybe then competition will further heat up and we will see the full blooming of Masbate port.
But they have to get that passenger terminal fee down. It is much higher than Zamboanga port when that port is better than Masbate port and the passenger terminal is not really needed by most of the ship passengers. A sore point really and that must change.


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Organizations are making strides to become more inclusive. Team performance improves by 50 percent when everyone feels included—resulting in better business performance and outcomes.
I&D maturity is not simply about a mantra or programs that are seen to do right: They must make the workplace experience right too—for everyone. Each individual needs to experience the impact of I&D programs and have a fair chance to get interviewed, hired and promoted.
But, as our latest research reveals, there is still a gap between what companies are doing and how the workforce evaluates their impact. The Accenture I&D Insights Survey examined the effectiveness of I&D efforts globally across five key industry sectors: Retail, Consumer Goods, Travel, Industrial and Life Sciences. The research focused on the four cornerstones which have the greatest influence on I&D maturity: Strategic intent; Leadership behaviors; Inclusive culture; and Talent actions.
The aim of the research was to evaluate the impact I&D initiatives have on the people who they are designed to help. We analyzed I&D impact among different groups, notably between I&D / HR practitioners responsible for implementing I&D programs and the people affected by them. The study covered 1,340 executives representing organizations valued at >$1billion.
*The Science of Inclusion, C. Cox et al, NeuroLeadership Journal, Vol 6, 2016DOWNLOAD REPORT [PDF]
While HR practitioners and non-practitioners broadly agree that organizations are taking steps to advance I&D, dig below the surface and views vary considerably, with factors like industry, geography, gender and ethnicity all playing a part.
In addition to the ratings on various aspects of I&D effectiveness, an overall maturity index scoring system was developed which rates organizations on maturity up to a highest score of 200. The results revealed disparate scores across industries and regions that were quite interesting.
Looking at the HR practitioners, men and women assess progress on I&D differently.
Of the men in HR, 51 percent feel their organizations are at the point of measuring the impact of their I&D initiatives, compared to just 33 percent of women who assess their organizations the same way.
Ethnic minority women employees rate progress on I&D differently to their non-minority counterparts. Ethnic minority women are twice as likely to rate their organizations as 'managing the minimum' (18 percent) compared to just 9 percent for non-minority women.
Respondents in the retail sector give their organizations a significantly lower score on overall maturity (174) than their counterparts in other Products sectors, including Consumer Goods (183), the highest scoring industry overall; Travel (182); Industrial (181); and Life Sciences (180).
We also found significant regional differences on ratings of I&D maturity. Respondents in North America score their organizations' I&D maturity significantly lower (171) than their counterparts in other regions whose scores range from 177 in Europe to 192 in South Africa.
In organizations that can be described as truly human, people are encouraged to bring their "whole", most authentic self to work and to be comfortable in doing so. These organizations understand how to maximize the positive impacts of a genuinely diverse and inclusive workplace culture.
To achieve this at Accenture, we have developed, and are continually refining, innovative approaches and tools to measure how closely our employees' attitudes align with our I&D initiatives. These include the Accenture I&D Maturity Index and Accenture I&D Framework. Together, they provide a structured approach that organizations can use to advance their journey to become a truly human business.
Accenture I&D Maturity Index
The I&D Maturity Index provides a truly meaningful measure of the maturity of an organization's I&D initiatives.
Accenture I&D Framework
The I&D Framework provides a basis for evaluating maturity as well as a roadmap for what needs to be achieved.
At each level of the I&D Framework, organizations are assessed on four cornerstones which inform specific actions on the journey to I&D maturity. It's an approach enabled by metrics and analytics, communication and change management to keep companies on track, while engaging with external networks to grow the talent pool and lead change.
1. Strategic intent:
Is I&D integrated in overall company growth strategy and communicated throughout the organization?
2. Leadership behaviors:
Does leadership ensure that those with different backgrounds are welcomed, treated equally and their voices heard?
3. Inclusive culture:
Do people of all backgrounds feel included, welcome, valued and respected for their individual differences?
4. Talent actions:
Do talent programs attract, retain, develop and build more diverse and inclusive teams at all levels?
The journey to I&D maturity is continuously evolving. Our four-stage maturity model is a useful way to assess impact against each of the four cornerstones to understand the current situation and inform future opportunities.
Do internal policies ensure that external legal requirements are met?
Are programs provided to address specific challenges and gaps?
Is there a comprehensive strategy and framework to ensure goals are measurable and will be achieved?
Integrated & sustainable
Is I&D deeply ingrained into the fabric of the organization?
As the research indicates, simply having I&D programs in place is not enough. The true success of I&D initiatives depends on the impact they have, and that often means different things to different people. With the right model, tools and approach, companies can go beyond the basics to ensure their programs are genuinely making a tangible impact for each individual person they are designed to support.
That means embedding measures to assess the I&D impact of the four factors that most strongly influence I&D maturity:
Is there strategic intent to integrate I&D?
Do leadership behaviors support I&D?
Is an inclusive culture actively fostered?
Do talent actions encourage I&D?
With the capability to evaluate I&D impacts holistically, organizations can assess how effectively they are executing on the I&D initiatives that are most important to employees, while accounting for multiple variables such as geography, gender, ethnicity, sexual orientation, or disabilities. And, by doing so, make I&D more than a mantra and accelerate the organization's journey to become a truly human business.


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Springfield T.C. Williams guard Christian Roberts personally outscored West Springfield 15-14 in the first half of Monday's contest and showed no signs of slowing down in the second.
The senior converted a three-point play in the opening minute of the third quarter to extend the Titans' lead to 14 points. But later in the period, Roberts came out of the game after injuring her left wrist while playing defense. With Roberts, who had scored 18 of TC's 31 points, on the bench, West Springfield closed the third quarter with a flurry, outscoring the Titans 11-3 during the final two minutes of the quarter.
With a double-digit lead trimmed to three entering the fourth quarter, the Titans' mental toughness would be tested. But rather than fold, TC regrouped and handed the West Springfield girls' basketball team its first home loss since 2009.
THE TITANS defeated the Spartans 50-39 on Jan. 28 at West Springfield High School, leaving the teams tied atop the Patriot District standings. According to the WSHS athletics Web site, it was the Spartans' first home loss since falling to T.C. Williams on Feb. 3, 2009. West Springfield had won three Patriot District championships, made a trio of state tournament appearances and captured one Northern Region title since the last time it lost on its home floor—and the Titans ended the streak with their most productive player of the evening sitting on the bench for the final 10 minutes.
"Christian's a senior and she came up and played like a senior tonight," TC head coach Kesha Walton said. "We were feeding off her energy—she was hot early. I think that when she went out initially, I think we kind of panicked. I talked to them, settled them down a little bit and said we can still do this."
"People were thinking it was a fluke that we beat them the first time. Now we proved that it wasn't and we're definitely a better team."
--- TC sophomore Rejoice Spivey
TC entered the fourth quarter with a 34-31 lead. Rejoice Spivey scored on a reverse layup and Megan Laychak and Angie Schedler each buried a 3-pointer to extend the Titans' lead to 42-31 with 5:33 remaining. West Springfield eventually pulled to within five, but TC's Grace Peterson answered with a three-point play, giving the Titans a 47-39 advantage with 2:08 remaining in the contest.
"Coach just told us to calm down," Spivey said. "We trusted each other. Even though Chris was out, we've got other people on the court that can make plays, so we just made plays."
For the first two-plus quarters, the Titans didn't need anyone else to make a play. Roberts scored eight points in the opening quarter, beating West Springfield off the dribble and knocking down jumpers. She added seven points in the second, including a 3-pointer from the left wing with 3:12 remaining in the first half. Roberts' three-point play in the opening minute of the third quarter gave her 18 points for the night.
Roberts credited her success to a hot shooting hand and the Spartans' decision to play man-to-man defense.
"When they play their zone, it's hard to score," Roberts said. "But when they [play] man, it's like [it's time to] go to the basket and score on them. They can't really match-up that well with us because of [our] quick guards. If they're giving it to me, I'm going to take it."
West Springfield junior Amy Berglund spoke after the game about the Spartans' defensive shortcomings.
"[The Titans] were just attacking," she said, "and we weren't able to stop it."
Walton said Roberts has played well of late.
"She understands what her role is and she's accepted the challenge of being in that senior leadership role," Walton said. "I talked with her before the game and I said, 'Look, you're a senior. This will be a shining moment for you. In the past three seasons you weren't able to beat them on their court. This is a great opportunity—you won't get it again.'"
TC defeated West Springfield for the second time this season. The Titans won 56-42 on Jan. 4 at T.C. Williams High School, handing the Spartans their first Patriot District loss since 2009.
WEST SPRINGFIELD had won the last nine meetings between the teams, including victories over TC in the 2011 and 2012 district championship games and the 2011 Northern Region final.
"People were thinking it was a fluke that we beat them the first time," Spivey said. "Now we proved that it wasn't and we're definitely a better team."
Spivey finished with 12 points for TC and Schedler added nine.
Berglund led West Springfield with 18 points. Freshman guard Haley Blankinship finished with seven.
"[Blankinship] likes attacking the bucket and that's good," West Springfield head coach Bill Gibson said. "Some of them fell tonight and that was good. It definitely helped keep us in the game."
TC defeated Lee 49-20 on Wednesday to improve to 12-7 overall and 9-2 in the Patriot District. Roberts said via Twitter she planned to play on Friday, Feb. 1 when TC will travel to face South County at 5:45 p.m.
West Springfield beat South County 70-32 on Wednesday, improving its record to 16-3 overall and 9-2 in the district. The Spartans will travel to face West Potomac at 7:30 p.m. on Friday, Feb. 1.


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Frequencies: T57 configuration (171.045 MHz & 171.845 MHz)
Gently used in perfect working condition. In original box - Includes transmitter, receiver, subminiature clip-on lavalier microphone, and all original accessories, including monitor earphone (original sealed packaging, never used), coiled audio signal cable, and 1/8" mini-plug to 1/4" adapter.
From the Audio-Technica website:
Audio-Technica's PRO 88W VHF wireless microphone systems are designed for camcorder and other applications requiring a small, easily portable wireless. Equipped with a flexible detachable antenna and a choice of two transmitter and receiver frequencies on each system, the small and inconspicuous VHF wireless system will mount on the light shoe of camcorders or on the back of a camera itself with a Velcro attachment. For fixed installations, a 9V DC input is available on the receiver. Eight VHF channels are available for interference-free operation in virtually any location.
From Amazon's website:
Provides freedom of movement for video production, computer applications and business presentations
Two switchable frequencies for interference-free operation
High-band VHF operation for superior sound
Normal operating range 100'; up to 300' under optimum conditions
Durable, flexible antenna can be positioned for best reception
Real-time monitoring capability with included earphone
Rugged design and construction with handsome non-reflective finish
$99 plus $8.00 shipping
NOW $75.00 + $8.00 shipping.


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LEGO The Lord of the Rings on the Wii follows the original storylines of The Lord of the Rings: The Fellowship of the Ring, The Lord of the Rings: The Two Towers, and The Lord of the Rings: The Return of the King, taking players through the epic story events with the humor and endless variety of LEGO play. Trusted with the dangerous task to destroy an ancient magical ring that threatens all, Frodo is forced to leave his peaceful home. But the ring wants to be found and the road to Mount Doom, the only place where it can be destroyed, will be perilous and riddled with Orcs and fouler things.
Super Gamer Dude
Nintendo Wii
The fact that the developers at Traveller's Tales have waited so long to transform the Lord of the Rings trilogy into a LEGO game is at first surprising. But since 2005 and the release of LEGO Star Wars, Traveller's Tales has tweaked and expanded their simple formula of taking well loved movie franchises and reinterpreting them into simple LEGO puzzle/action games into an epic art. Seven years ago The Lord of the Rings franchise would have been reduced to ten playable levels per movie. The best part though of LEGO Lord of the Rings is the gorgeous and faithful open world. Traveller's Tale's base formula would have grown tiresome fast if they had simply leaned on the Lord of the Rings films' appeal to sell games, but their devotion to the source material, and utilization of simple yet effective gameplay mechanics, makes LEGO: Lord of the Rings a solid entry for LEGO and Lord of the Rings devotees alike.
The look of this game is as inventive and amusing as any other LEGO reimagining, continuing the tradition from LEGO STar Wars III, The Clone Wars, however, Traveller's Tale include vistas and elements which appear closer to diaramas than LEGO sets. The variety is good and allows the visuals to really capture from the movies what LEGO blocks cannot.
Gameplay in the LEGO games has always broken down to simple puzzles and light boss battles, mixed together in a very straightforward way. Where previous LEGO games have differed though, is that instead of offering a level by level recreation of the feature films, the world of the films is recreated for the player to explore. This is an invitation to nostalgia. Many players will find more pleasure in exploring the detailed world of Middle Earth for every last collectible than playing the game's vanilla story missions. Not that there is anything wrong with the story missions specifically. They are well worth playing in order to enjoy the always amusing cutscenes. The developers have always had a loving sense of humor toward these beloved characters and franchises. The humor in this game is no different. The majority of the enjoyment in the story missions also comes from replay. LEGO games might be the most jam packed full of collectibles and hidden extras of any franchise ever. After finishing a level for the first time, the real fun begins. Freeplay mode allows players to go through any level with any character they want. This unlocks a whole new layer of puzzles and hidden goodies to uncover. Every unlockable character has unique abilities which are worth experimenting with.
LEGO Lord of the Rings is not the most faithful recreation of the Lord of the Rings universe, but it is certainly the best. Other attempts to adapt Lord of the Rings into a video game have failed mostly because they all got away from what makes an adaptation great. There is a secret Traveller's Tale knows and should stamp on the back of every license developer's eyelids, take what is there, and have fun with it.
|Submitted by
|Cheat Title
Nov 17, 2014


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Ginger beer, lime, soy and chilli marinated and glazed vegetarian chicken with a puy lentil, yellow bean and soya bean salad
When I left the corporate world three years ago, I accepted some truths about myself and life and also resolved to live/be alive/ thrive/bloom/ differently.
I told myself that I would not choose work on the basis of money.
I resolved that I would aim to be happy in each day, for that day.
I committed to being more grateful for each of the blessings that currently I have in my life.
I decided that there would be no gossip in our home, no unnecessary negative or weighing talk.
I devoted more energy and time to love and to spending time with my loved ones.
I set to strive to stop measuring myself by successes and failures.
And I absolutely, most certainly did not want to be commuting into central London for work, again. No. No.
Sounds simple, doesn't it?
On Tuesday this week I went for a physiotherapy appointment and the physiotherapist made barely any eye contact with me at all and spoke to me in a uniform and mechanical tone. When I asked a question, she sighed deeply and answered into her computer screen, 'nooooo, I told you…'
She later happened to ask me what I did before my son was born. I then noticed her well sculpted nose and thick layer of eye liner. She seemed tired and wore a diamond on her necklace that carried a leaf. 'Oh, that's interesting'. We then had an actual conversation before I left to go to the bank where really pleasant young chap with streaks of purple and pink in his otherwise almost-black hair helped me swiftly and politely. He chuckled respectfully about how he was cooped up indoors on a sunny day, but that's what happens when you have a 'normal' 9-5 job, isn't' he joked. Isn't it. It got me thinking about how lovely 'normal' is. That feeling of waking up in the morning purposefully and ready to do a good day's work…even complaining about the traffic or that annoying email full of demands and not enough time. The banter, the parking issues, it is all reassuringly normal; validation that we are all part of a moving engine.
Anyway, later that day, as I headed over to a foodie event I was on the phone to my brother who is not a Londoner (but of course loves London) pronounced his obvious qualms about tube travelling and the maze that the map can be. He thought he would get lost, but I reminded him that he was on the circle line, it goes in a circle? He remarked how the masses of suited and trainer clad commuters moved pensively and determinedly about like wasps that were evidently very, very late. But they read. And I missed it. I felt glad that my upcoming two opportunities are London based.
So, in truths there lies change.
Back to the World Cup 2014. I have absolutely no interest in football but if you do, here is a recipe that you can pick at from your sofa seated position and I promise you that it will titillate you. It really, really will because the ginger beer soaks right through the spongy soya textures and if you are not vegetarian, use chicken. It's a bit sweet, it's a bit spicy and it is wholly pleasurable in a lightly sticky way. I am thoroughly excited by this recipe and can't wait for you to try it.
Ingredients to serve 2
400g mock chicken (use the TKC vegetarian chicken)
450ml ginger beer
4 tbsp. soy sauce
2 tbsp. soft brown sugar
1 large red chilli, or more if you like
The zest of one lime
The juice of one lime
1 tbsp. groundnut oil
2-3 dried ginger roots
1 tbsp. chilli sauce (I use sriracha sauce)
2-3 spring onions, chopped into bite sized pieces
100g puy lentils
100g soya beans
100g yellow beans
- Defrost the TKC vegetarian chicken as per packet instructions and then in a large bowl add the mock chicken, chilli, lime zest, chilli sauce and ginger roots then pour in half of the ginger beer. Then add the brown sugar, soy sauce and the remaining ginger beer. Let it rest in the fridge for a couple of hours
- Prepare the puy lentils by boiling them for approximately 20 minutes, or per packet instructions. Boil the soya beans for 3-4 minutes and then rinse them in cold water. Boil the yellow beans for 8 minutes and then rinse them in cold water. Combine these three ingredients before cooking the mock chicken.
- In a non-stick pan heat the oil and then add the spring onion and sauté for a couple of minutes. Add the mock chicken without the juices and stir through. Then ladle in the juices, two at a time until the moisture is soaked into the mock chicken. You should see a golden and lightly sticky glaze develop. Repeat this process until ¾ of the marinade is used up. Use one ladle for the salad and then serve whilst the mock chicken is hot.


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Matthew unlocked a badge!
Fruits of Your Labor (Level 20)
It's been a long day and now it's time for a reward. Crisp, tasty and refreshing, enjoy that delicious fruit beer! That's 100 different beers with the style of Fruit Beer or Sour - Fruited. Try 5 more for Level 21.
Thu, 25 Jun 2020 22:46:39 +0000


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The United States Parachute Association has released the good news that 2009 marked the lowest skydiving fatality rate for one year in almost half a century: 16 deaths in nearly three million jumps by over 32,000 USPA members at 220 drop zones across the U.S. Of those three million, 400,000 were by people making their first jump. Not since 1961 has an annual fatality total been lower, at 14. But there were only 3,353 members then. Total jumps that year weren't tallied, but suffice to say there were far fewer. So the death rate was surely much higher.
The 1970s averaged 42.5 fatalities per year, but that 10-year average has steadily dropped: The 1980s saw a 34.1 average; the 1990s, 32.3; and the 2000s 25.8. The USPA attributes the decline to safer equipment, better training, and the personal commitment of each skydiver, instructor, rigger, and drop zone manager.
Sixteen in three million is about one death for every 62,500 jumps. Not quite as good as the 2008 rate of one airline passenger death for every eight million airplane passengers who flew that year. But we'd all agree that skydiving may always be a little riskier than simply flying on an airplane. They're better than the odds that you'll die accidentally from a fall due to snow or ice: 1 in 1,270, something people in the mid-Atlantic are thinking about, maybe, right now after getting three feet of snow this week. They're also better than the odds that you'll become employed as a fashion designer: 1 in 7,990.
Frankly, I've never understood odds, and struggled with the probability and statistics class I took in college. That professor would probably tell me that just because you can divide three million by 16 and get one death for every 62,500 jumps doesn't actually mean the odds are one in 62,500. That just happened to be the rate last year.
I've never skydived. I did bungee jump once, 20 years ago, and was somehow comforted by the fact that I was attached to the bridge the whole time. Didn't have to rely on the mysterious function of a rip cord, or the proper unfurling of the chute. To this day I can't seem to find firm numbers on fatalities per million bungee jumps, or whatever. I'm oddly comforted by that too. There are numbers all over the place on the web. Helen, a student in Mr. Varsava's Grade 11 Physics class back in 2004, somehow dug up information that the odds of death by bungee jumping are one in 500,000. I'm going with that, even though I'm done bungee jumping.
By the way, the folks shown here aren't skydiving over water for safety reasons. They're swooping, which is a popular event at skydiving meets. Swooping is part of canopy piloting competitions, the most extreme discipline in the sport of skydiving. Competitors are judged on speed, distance, and zone accuracy. The swooping part, which obviously comes last, also provides some giddy fun, particularly when an overambitious swooper touches down on the water too far from shore and sinks before getting to dry land. That's called "chowing."
Sorry, no data available on the odds of chowing.
A Diving Rate
The United States Parachute Association has released the good news that 2009 marked the lowest skydiving fatality rate for one year in almost half a century: 16 deaths in nearly three million jumps by over 32,000 USPA members at 220 drop zones across the U.S. Of those three million, 400,000 were by…


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At its launch this week, the Digital Public Library of America (DPLA) is featuring StackLife DPLA as an example of how the DPLA's collection of books can be mashed up with other collections and browsed in highly innovative ways.For all those who are aware of digital book collections, the inclusion of the Hathi Trust and the Internet Archive's Open Library are significant advances. The official launch of the website is at Noon Eastern Time, 18 April 2013.
StackLife DPLA, launched today by the Harvard Library Innovation Lab, lets users find and freely read 1.7 million books from the DPLA, the Biodiversity Heritage Library, the Hathi Trust and the Internet Archive's Open Library.
StackLife DPLA enables users to browse via scrollable virtual shelves that cluster—and can instantly re-cluster—books based on their multiple subject areas. With a click, a user can read the book online.
The depth of color of a book on a StackLife DPLA shelf indicates how often a work has been read. The length of that image of the book indicates how long ago it was published and its thickness indicates how many pages are in it.
Thursday, April 18, 2013
Real News: Digital Public Library of America goes live today with StackLife
The Digital Public Library of America (DPLA) is a major step in making major digitized collections available in one place on the Web. Today the DPLA announces the following:
2 comments:
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22 November 2011 - Boston, MA and Lucca, Italy
McGladrey and Tagetik Partner to Deliver Enterprise Performance Management Services
Budgeting and modeling, consolidation, regulatory compliance, enterprise governance and disclosure management to corporate leadership throughout the U.S.
RSM McGladrey, Inc. which operates with McGladrey & Pullen LLP under the McGladrey brand as the United States' fifth largest provider of assurance, tax and consulting services, and Tagetik, a global provider of enterprise software solutions for performance management, governance, risk & compliance and business intelligence, today announced the formation of an alliance to make available corporate performance management support for McGladrey clients across the United States.
Under the agreement, RSM McGladrey will resell and implement the full Tagetik software platform, including solutions for corporate consolidation, budgeting and modeling, regulatory compliance, enterprise governance and disclosure management throughout the U.S.
"At McGladrey, we understand the corporate performance needs of our clients," said Dean Nelson, RSM McGladrey managing director responsible for performance management offerings. "We are pleased to partner with Tagetik to combine our deep understanding with Tagetik's visionary product, which will enable us to provide an additional competitive, high-value solution to our clients."
"Tagetik has a strong relationship with partners that allow us to understand market dynamics and respond with valuable product offerings," said Mark Corsetti, VP and General Manager of Tagetik North America. "We are very pleased to be working with McGladrey as this partnership solidifies our solution offering in North America. The combination of our product and their extensive industry expertise will allow us to provide competitive, high value solutions to customers."
"Tagetik operates in more than 20 countries, and its market experts are committed to the success of its customers across the globe, including some of the largest Fortune 1,000 companies representing all industry sectors," said Todd Breshears, director in RSM McGladrey's Boston office. "We are excited about this new alliance, and look forward to using Tagetik's unique solutions to help meet and succeed our clients." To learn more about the McGladrey-Tagetik partnership, visit the McGladrey website: www.mcgladrey.com
About RSM McGladrey Technology Services
At McGladrey, we understand how people, processes and technology interact to ensure organizational effectiveness. By combining technical expertise and business savvy with a full scope of IT services, we can assess complex situations, and devise and implement effective solutions quickly and cost effectively. For more information, join the McGladrey Technology Services Facebook fan page and/or follow @McGladreyTech on Twitter.
About McGladrey
McGladrey is the brand under which RSM McGladrey, Inc. and McGladrey & Pullen, LLP serve clients' business needs. Together, they rank as the fifth-largest U.S. provider of assurance, tax and consulting services, with 7,000 professionals and associates in more than 80 offices. The two firms operate as separate legal entities in an alternative practice structure. McGladrey & Pullen is a licensed CPA firm that provides assurance services. RSM McGladrey is a leading professional services firm providing tax and consulting services. Both firms are members of RSM International, the sixth-largest global network of independent accounting, tax and consulting firms. For more information, visit the McGladrey website at www.mcgladrey.com, join our Facebook fan page at McGladrey News and/or follow us on Twitter @McGladrey.
Request a Demo
Our personalized demo allows you to speak directly with a senior solution specialist and discover the key functionalities of CCH Tagetik.
Would you love to know more about CCH Tagetik?
For more information, please complete the form and a member of our team will reach out to you shortly!


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Established in 1885, The Dallas Morning News is Texas' leading newspaper. Its portfolio of print and online products reaches an average daily audience of more than 1.1 million.
The newspaper has received nine Pulitzer Prizes since 1986, as well as numerous other industry awards recognizing the quality of its investigative and feature journalism, design and photojournalism. In 2010, The News received the Pulitzer Prize for an editorial series highlighting the economic disparity between the northern half and southern half of Dallas.
The Dallas Morning News is the flagship newspaper subsidiary of A. H. Belo Corporation.


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2012 Bring it on! :-D New year, new me! I'll try to be more diligent on my postings. In fact, I'm stashing several Korean Cosmetics mostly from SkinFood's from my hauls here, here, and my latest $100 Korean Cosmetics splurging on eBay, but I hardly ever started halfway using most of them let alone do reviews. I reckon I also need to clean up some of my photo files. So here goes...best to jumpstart it with another recent haul photo. Tada! :-D
I'm actually sharing these loots with my sister. She's now a SkinFood/Korea Cosmetics fan too. I'm the more outgoing and sort of a brand hopper when it comes to BB cream, but she's committed to the Peach Sake Lines of SkinFood. She has an oily/sensitive skin type. And she's standing by the product/s recommended for her skin type.
|My 2011 last hurrah for Korean Cosmetics e-Bay Ph shopping spree complements of GoBiz Korea. So yeah, I'm one lucky unstoppable #Korean cosmetics addict gal! ^_^ I love. :-D
SkinFood Peach Sake BB Cream No. 2
SkinFood Gold Caviar Moist Fitting Cake No. 2
SkinFood Rose Cheek Choc Blusher No. 1
SkinFood Honey Glossy Rouge No. 362 Sugar Jelly Lipstick
SkinFood Choco Smoky Volume Mascara
SkinFood Black Bean Lip Liner
More SkinFood Platinum Grape Cell Essential BB Cream Samples
Other brands: Samples of Innisfree Jeju Volcanic Pore Clay Mask
Innisfree Eco Natural Cover BB Cream
Etude House HD Beam Fantastic Heart Pearl Nail Polish
Overflowing freebies below
|Freebies...Love them! Feels like Seoul Shopping too! I'm really too happy with you.. BHappywithMe :-D
|Meet my sister with her mainstay Peach Sake BB Cream No. 2 plus other SkinFood lovelies! :-D
|Of Cloud and Star...SkinFood Magic Hair Pads sells on eBay Ph for Php 50/pack. I'm definitely getting more of these. These cute hair pads are actually velcro hooks that keeps the hair in place away from the face. These lovelies save the hair from being wavy from use of hair claws or clips. And they're quite powerful in keeping a good portion of hair in place. I have them on me here.:-D
|SkinFood Black Bean Lip Line Pencil Shade No 3 Peach Pink. This actually comes with a lip brush on one end too. It has good pigmentation and lasting power too.
|Cotton Swab-like are SkinFood Eggplant Eye Make-up Remover Bar
|Full-Size Comes in a bar-like cotton swab case with 20 swabs.
- Hold the lid side of the cotton swab upward, and then pull up the lid in a gentle turning motion.
- Leave the lid side of the cotton swab opened, and hold the Remover Bar still until it is completely soaked by the liquid (remover).
- Use the bottom side of cotton swab to remove makeup, and then wipe off surplus remover surplus remover with the lid side of the cotton swab.
- Very handy.
- Cools and refreshes while cleaning.
- Doesn't sting or cloud.
- Doesn't work (at all) on my waterproof Mascara!
Overall, this is a good makeup eraser, and will work on non-waterproof eye makeup. It doesn't feel oil-based. Although, I can't really tell since I just tried two swabs, and I had to reach for the Seaweed waterproof makeup remover right after. Will I repurchase? These are definitely nice-to-have's especially when traveling. Other than that, a good ol' cotton swab dipped in a makeup remover will do the same trick. ;-D
Oh my, I just did three items here...definitely more to come. I have sworn off hauling for the moment. (Wish me luck! ;-D) Except if they come in for free like these lovelies, why not!? ;-D
Anything in the loot you want me to review after? Please let me know. :-D


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After Christmas with my family, we spent a few days in Oklahoma with Curt's side of the family! Here's Kinsley with her 2nd cousins Ellison and Quinlynn - they all got American Girl dolls for Christmas so they had a great time playing with them together!
Curt's brother Travis
While we were there, Oklahoma had this super fun leggo exhibit going on! Kaden LOVED every minute of it - here he is at the HUGE leggo table making his own creation!
Curtis and Kinsley getting in on the fun!
Kaden, Grandma, and Grandpops looking at some of the buildings made out of leggos!
funny boy
The next day we went to the Oklahoma zoo - it was a fantastic zoo and we all had a great time!
From l to r: Me, Curt, Kaden, David, Shelley (Curt's aunt), Ellison, Kinsley, Quinlynn, Susan, Chandler (Curt's cousin), Kim, Malakai, Jared, Courtney, and Carol (another one of Curt's aunts)
Swinging by the monkeys with Grandpops
Curtis, with Kaden, Kinsley, David and Susan by the lake
This sums up the wonder my kiddos have when they are at the zoo - they LOVE it!
Kinsley, Malakai, and Kaden on a tortoise
Curtis's sister Courtney and her boyfriend Jared
Curtis's other brother Kevin, with Kaden and Corbin
Kinsley and Emerson playing and opening presents!


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Our Government
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Doing Business
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Our Government
Government Leadership
Senior Leadership
Communications Manager
Communications Manager
Communications Manager Patty Prince
The Communications Manager for the City of Manassas is hired by the City Manager to enhance the City's communications goals with residents, businesses, media and City employees.
Patty Prince was hired in August 2012 and has more than 30 years experience in communications and marketing. Prior to her arrival at the City, Prince worked as public information specialist with Prince William County. She has a Bachelor of Arts Degree in Communications from Virginia Tech.
Career Highlights
Prince William County, Virginia - Public Information Specialist
PP Productions - Owner / CEO
Full-service agency providing writing, editing, graphic design, event planning, and organizational management to non-profit clients in the Washington, D.C. area.
Guest Services, Inc. - Marketing Coordinator
Professional Organizations & Memberships
3CMA (City-County Communications and Marketing Association) President Elect
Significant Accomplishments Awards & Recognitions
Graduate Phi Theta Kappa International Public Safety Leadership and Education Institute
3CMA Silver Circle Award Winner - Most Creative Event on the Smallest Budget
3CMA Savvy Award Winner - Branding/New Logo
3CMA Silver Circle Award Winner - Best Use of Facebook
Bachelor of Arts in Communications / Public Relations with an emphasis in Creative Writing and Marketing from Virginia Tech
Contact Patty Prince via
or phone (703) 257-8456.
City Manager
Deputy City Manager
City Attorney
City Clerk
Airport Director
City Clerk
Communications Manager
Community Development Director
Economic Development Director
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Delicious food from our family to yours.
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Happy New Year's Eve, Lovelies! Can you believe this year is coming to a close? It seems like we were just ringing in 2012 and now another year is in the history books. On the sparkliest night of the year, I thought I would bring you some of my favorite eye makeup products, perfect for creating a little NYE glam! I love many, many makeup products but here's my tried and true holiday look...
{Shop the Look Here}
eye paint / eye shadow / eye liner / glitter liner / mascara
When applying makeup, I spend the most time on my eyes. They are the focal point of our face and should definitely be played up! I'm a firm believer in an eye shadow base as it lays the foundation for the eye makeup. There's nothing worse than shadows and liners that move or bleed during the day and by the time you get home you look like someone gave you a shiner. To remedy this, I use eye paint by Mac in Bare Canvas. Now that I have the foundation set, it's time for the drama! Start with some dramatic eye shadows...I typically use three or four colors and for that reason, palettes are great. Follow up the shadow with a great liquid liner (this one is water proof!), then add some glitz and glitter with this fun and easy to use liner. Finally, apply your mascara.
There you have it...glamourous in a snap!
What do you use to glam up your NYE look? Do we use any of the same products?
What are your plans for tonight? Whatever you do, have fun and be safe. I'll see you in 2013!


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This section features contact information for those companies involved in taking American lamb from gate to plate. From auction barns, where sheep are sold, to the processors and wholesalers, where lamb is cut and packaged for sale to the foodservice industry and at retail, each plays an important role in ensuring a safe product for consumers of American lamb.
Official U.S. Standards for Grades of Lambs, Yearlings and Mutton Carcasses (pdf)
Official U.S. Standards for Grades of Lambs, Yearlings and Sheep (pdf)
Sheep Safety and Quality Assurance Trainers are also an important part of ensuring consumers are given the safety product. To schedule an SSQA Course, feel free to contact on of the SSQA Certified Trainers.
Suppliers: if you are interested in being listed, please contact us .
The lists provided on this site are offered for the convenience of users for informational purposes only and are not intended as endorsement or recommendation. Please contact us to suggest additional listings or to report errors.


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Pubmed du 11/05/19
1. Al-Ayadhi L, El-Ansary A, Bjorklund G, Chirumbolo S, Mostafa GA. Impact of Auditory Integration Therapy (AIT) on the Plasma Levels of Human Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Autism Spectrum Disorder. J Mol Neurosci ;2019 (May 9)
Neurotrophic factors, including the glial cell line-derived neurotrophic factor (GDNF), are of importance for synaptic plasticity regulation, intended as the synapses' ability to strengthen or weaken their responses to differences in neuronal activity. Such plasticity is essential for sensory processing, which has been shown to be impaired in autism spectrum disorder (ASD). This study is the first to investigate the impact of auditory integration therapy (AIT) of sensory processing abnormalities in autism on plasma GDNF levels. Fifteen ASD children, aged between 5 and 12 years, were enrolled and underwent the present research study. AIT was performed throughout 10 days with a 30-min session twice a day. Before and after AIT, Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Short Sensory Profile (SSP) scores were calculated, and plasma GDNF levels were assayed by an EIA test. A substantial decline in autistic behavior was observed after AIT in the scaling parameters used. Median plasma GDNF level was 52.142 pg/ml before AIT. This level greatly increased immediately after AIT to 242.05 pg/ml (P < 0.001). The levels were depressed to 154.00 pg/ml and 125.594 pg/ml 1 month and 3 months later, respectively, but they were still significantly higher compared with the levels before the treatment (P = 0.001, P = 0.01, respectively). There was an improvement in the measures of autism severity as an effect of AIT which induced the up-regulation of GDNF in plasma. Further research, on a large scale, is needed to evaluate if the cognitive improvement of ASD children after AIT is related or not connected to the up-regulation of GDNF.
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2. Baker EK, Arpone M, Aliaga SM, Bretherton L, Kraan CM, Bui M, Slater HR, Ling L, Francis D, Hunter MF, Elliott J, Rogers C, Field M, Cohen J, Cornish K, Santa Maria L, Faundes V, Curotto B, Morales P, Trigo C, Salas I, Alliende AM, Amor DJ, Godler DE. Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features. Mol Autism ;2019 ;10:21.
Background : Fragile X syndrome (FXS) is a common monogenic cause of intellectual disability with autism features. While it is caused by loss of the FMR1 product (FMRP), mosaicism for active and inactive FMR1 alleles, including alleles termed premutation (PM : 55-199 CGGs), is not uncommon. Importantly, both PM and active full mutation (FM : >/= 200 CGGs) alleles often express elevated levels of mRNA that are thought to be toxic. This study determined if complete FMR1 mRNA silencing from FM alleles and/or levels of FMR1 mRNA (if present) in blood are associated with intellectual functioning and autism features in FXS. Methods : The study cohort included 98 participants (70.4% male) with FXS (FM-only and PM/FM mosaic) aged 1-43 years. A control group of 14 females were used to establish control FMR1 mRNA reference range. Intellectual functioning and autism features were assessed using the Mullen Scales of Early Learning or an age-appropriate Wechsler Scale and the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2), respectively. FMR1 mRNA was analysed in venous blood collected at the time of assessments, using the real-time PCR relative standard curve method. Results : Females with FXS had significantly higher levels of FMR1 mRNA (p < 0.001) than males. FMR1 mRNA levels were positively associated with age (p < 0.001), but not with intellectual functioning and autistic features in females. FM-only males (aged < 19 years) expressing FM FMR1 mRNA had significantly higher ADOS calibrated severity scores compared to FM-only males with completely silenced FMR1 (p = 0.011). However, there were no significant differences between these subgroups on intellectual functioning. In contrast, decreased levels of FMR1 mRNA were associated with decreased intellectual functioning in FXS males (p = 0.029), but not autism features, when combined with the PM/FM mosaic group. Conclusion : Incomplete silencing of toxic FM RNA may be associated with autistic features, but not intellectual functioning in FXS males. While decreased levels of mRNA may be more predictive of intellectual functioning than autism features. If confirmed in future studies, these findings may have implications for patient stratification, outcome measure development, and design of clinical and pre-clinical trials in FXS.
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3. Bong G, Kim JH, Hong Y, Yoon NH, Sunwoo H, Jang JY, Oh M, Lee KS, Jung S, Yoo HJ. The Feasibility and Validity of Autism Spectrum Disorder Screening Instrument : Behavior Development Screening for Toddlers (BeDevel)-A Pilot Study. Autism Res ;2019 (May 10)
Although early screening is critical for individuals with autism spectrum disorder (ASD) in order to receive early intervention and improve function later in life, screening is often delayed. Limitations of existing screening instruments, and the need for a culturally appropriate early screening tool in Korean children, led us to develop Behavior Development Screening for Toddlers (BeDevel). The BeDevel assessment consists of two parts : BeDevel-Interview, a structured interview measure for parents/primary caregivers ; and BeDevel-Play, a play-based semi-structured observational measure in children. To examine the feasibility and validity of BeDevel, 155 children (N = 75 ASD, N = 55 typical development, N = 25 developmentally delayed) aged 18-42 months (M = 31.54 months, SD = 7.60) were examined through parent-reported screening questionnaires, BeDevel, and standard diagnostic assessments. When BeDevel items were analyzed using Cohen's kappa statistics, most items in BeDevel-Interview and all items in BeDevel-Play were reasonably consistent with diagnoses. We identified primary items, which were significantly interacted with actual diagnosis in the chi-squared test (P < 0.05, range = 0.000-0.032). Using cutoff numbers of items determined using the receiver operating characteristics curve, BeDevel showed satisfactory levels of sensitivity (83.33%-100%), specificity (81.25%-100%), positive predictive values (80.65%-100%), and negative predictive values (83.87%-100%), as well as high internal consistency (Cronbach's alpha = 0.866-959). The agreement between BeDevel and most other screening/diagnostic instruments was moderate (k = 0.419-1.000). These results suggest that BeDevel can be a useful instrument for early screening of ASD. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY : Although early screening is critical for individuals with autism spectrum disorder (ASD) in order to receive early intervention and improve function later in life, screening is often delayed. Limitations of existing screening instruments and the need for a culturally appropriate early screening tool in Korean children led us to develop Behavior Development Screening for Toddlers (BeDevel). The BeDevel assessment consists of two parts : BeDevel-Interview, a structured interview measure for parents/primary caregivers ; and BeDevel-Play, a play-based, semi-structured observational measure in children. In order to test the feasibility and validity of BeDevel, we analyzed preliminary data of total 155 children aged 18-42 months, examined through parent-reported screening questionnaires, BeDevel, and standard diagnostic assessments. When individual items were analyzed, responses of all BeDevel-Interview items and of most BeDevel-Play items well matched actual diagnoses, and we identified primary items, which were particularly useful in differentiating between the ASD group and the non-ASD group. With the optimal screening criteria determined, the BeDevel was able to identify individuals with a diagnosis of ASD and those without it, all at satisfactory levels. Lastly, BeDevel items were closely related as a set, and the BeDevel screening results were reasonably consistent with the results of most other screening/diagnostic instruments. These results suggest that BeDevel can be a useful instrument for early screening of ASD.
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4. Bryant LK, Woynaroski TG, Wallace MT, Cascio CJ. Self-reported Sensory Hypersensitivity Moderates Association Between Tactile Psychophysical Performance and Autism-Related Traits in Neurotypical Adults. J Autism Dev Disord ;2019 (May 9)
Atypical responses to tactile stimulation have been linked to core domains of dysfunction in individuals with autism spectrum disorder (ASD) and phenotypic traits associated with ASD in neurotypical individuals. We investigated (a) the extent to which two psychophysically derived measures of tactile sensitivity-detection threshold and dynamic range-relate to traits associated with ASD and (b) whether those relations vary according to the presence of self-reported sensory hypersensitivities in neurotypical individuals. A narrow dynamic range was associated with increased autism-related traits in individuals who reported greater sensory hypersensitivity. In contrast, in individuals less prone to sensory hypersensitivity, a narrow dynamic range was associated with reduced autism-related traits. Findings highlight the potential importance of considering dynamic psychophysical metrics in future studies.
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5. Coban N, Gokcen C, Akbayram S, Calisgan B. Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder : Elongated Collagen-Adenosine Diphosphate and Collagen-Epinephrine Closure Times. Autism Res ;2019 (May 11)
Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA-100) device by measuring collagen-ADP and collagen-epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (P > 0.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (P = 0.047). Moreover, in terms of platelet functions, the elongation in collagen-ADP and collagen-EPI closure times were significantly higher for the ASD group (P = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY : Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls.
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6. Crandall MC, Bottema-Beutel K, McDaniel J, Watson LR, Yoder PJ. Children with Autism Spectrum Disorder May Learn from Caregiver Verb Input Better in Certain Engagement States. J Autism Dev Disord ;2019 (May 9)
The relation between caregiver follow-in utterances with verbs presented in different states of dyadic engagement and later child expressive verb vocabulary in children with autism spectrum disorder (ASD) was examined in 29 toddlers with ASD and their caregivers. Caregiver verb input in follow-in utterances presented during higher order supported joint engagement (HSJE) accounted for a significant, large amount of variance in later child verb vocabulary ; R(2)= .26. This relation remained significant when controlling for early verb vocabulary or verb input in lower support engagement states. Other types of talk in follow-in utterances in HSJE did not correlate with later verb vocabulary. These findings are an important step towards identifying interactional contexts that facilitate verb learning in children with ASD.
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7. Gyawali S, Patra BN. Autism Spectrum Disorder : Trends in research exploring etiopathogenesis. Psychiatry Clin Neurosci ;2019 (May 11)
Autism Spectrum Disorder is a neurodevelopmental condition in which affected individuals have difficulties while interacting and communicating socially, and repetitive behaviors. It has a multi-factorial etiology. Various risk factors including genetic and environmental influences have been explored while trying to understand its causation. As older evidence was suggestive of a high heritability, a majority of research focused on finding the underlying genetic causes of autism. Due to these efforts, there have been advances in the knowledge of some of the genetic factors associated with autism. But a recent trend also shows an increasing interest in exploration of various potential environmental triggers. These efforts have brought us closer to understanding the elusive disorder more so than ever before. The current paper discusses the recent trends in research exploring the etiopathogenesis of Autism Spectrum Disorders. This article is protected by copyright. All rights reserved.
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8. Liu XY, Xiao YK, Hwang E, Haeng JJ, Yi TH. Anti-photoaging and Anti-melanogenesis Properties of Ginsenoside C-Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD-ginsenoside. Photochem Photobiol ;2019 (May 10)
Ginsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound-Y (C-Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB-irradiated NHDFs and its potential for use as an anti-hyperpigmentation agent through ginsenoside C-Y as a functional food and cosmetic ingredient. Ginsenoside C-Y is a natural antioxidant isolated from the American ginseng PDD-ginsenoside. Our data showed that ginsenoside C-Y block UVB-exposed ROS, restrict MMP-1 production, and promote procollagen type I synthesis. Interestingly, ginsenoside C-Y suppresses UVB-exposed VEGF, and TNF-alpha secretion, could be related with NFAT signal path. Ginsenoside C-Y has exhibited photoaging effects by increasing TGF-beta1 level, fortifying Nrf2 nuclear translocation, and restricting AP-1 and MAPK phosphorylation. Assessment of the melanogenic response indicated that ginsenoside C-Y inhibited melanin secretion and tyrosinase activity and decreased melanin content in melan-a and zebrafish embryos. These results suggest that ginsenoside C-Y can be used as a potential botanical agent to protect premature skin from UVB-induced photodamage and prevent skin hyperpigmentation. This article is protected by copyright. All rights reserved.
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9. Locke J, Kang-Yi C, Pellecchia M, Mandell DS. It's Messy but Real : A Pilot Study of the Implementation a Social Engagement Intervention for Children with Autism in Schools. J Res Spec Educ Needs ;2019 (Apr) ;19(2):135-144.
Social impairment represents one of the most challenging core deficits of autism spectrum disorder (ASD) and greatly affects children's school experiences ; however, few evidence-based social engagement programs have been implemented and sustained in schools. This pilot study examined the implementation and sustainment of a social engagement intervention, Remaking Recess, for four elementary-aged children with ASD and four school personnel in two urban public schools. The improved peer engagement and social network inclusion outcomes suggest that Remaking Recess can be feasibly implemented in under resourced public schools with fidelity and has the potential to improve child outcomes for children with ASD.
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10. Passalacqua C, Garcia M, Sepulveda E, Toledo D, Valencia M, Arancibia M. Psychological and cognitive evaluation of autism in a patient with MOMO syndrome : a case report and literature review. Medwave ;2019 (May 2) ;19(4):e7622.
MOMO is an acronym for macrosomia, obesity, macrocephaly and ocular abnormalities. The syndrome was first described in 1993, with a total of nine patients published thus far. All the cases presented intellectual disability and in one case autism was described. We present a new case of a patient with MOMO syndrome, who consulted for hallucinatory phenomena. He completed a neuropsychological, clinical and cognitive evaluation, showing a borderline intelligence quotient and fulfilled the criteria for autism spectrum disorder. This is the first neurocognitive evaluation of a patient with MOMO, supporting the use of standardized scales in order to assess the autism and other psychiatric comorbidities in patients with genetics syndromes.
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11. Raccio A. J. Newman : To Siri with Love : A Mother, Her Autistic Son, and the Kindness of Machines : HarperCollins, New York, NY, 2017. J Autism Dev Disord ;2019 (May 9)
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12. Strugnell A, Leonard H, Epstein A, Downs J. Using directed-content analysis to identify a framework for understanding quality of life in adults with Rett syndrome. Disabil Rehabil ;2019 (May 10):1-8.
PURPOSE : Rett syndrome (RTT) is a rare neurodevelopmental disorder mainly affecting females and is caused by a mutation in the MECP2 gene. Recent research identified the domains of quality of life (QOL) important for children with RTT but there has been no investigation of domains important for adults. This qualitative study explored QOL in adults with RTT and compared domains with those previously identified for children. METHODS : The sample comprised parents and/or primary caregivers of 20 adults, aged 18-38 years, who were registered with the Australian Rett Syndrome Database. Semi-structured telephone interviews were conducted to investigate aspects of life that were observed to be satisfying or challenging. Data were analyzed using directed content analysis, based on existing QOL domains for children with RTT that related to health and wellbeing, daily activities, and community immersion and services. RESULTS : Each of the domains identified for children with RTT was represented in the adult dataset, with no new domains emerging. CONCLUSION : This is the first study to identify QOL domains important for adults with RTT. Health and therapy needs are ongoing during adulthood but services may be limited. Findings will guide choice of an appropriate QOL measure for this group. IMPLICATIONS FOR REHABILITATION Knowing the important domains of quality of life enables clinicians and service providers to systematically review and address key management issues. Despite a high level of dependency and sometimes poor health, parent caregivers perceive potential for strong quality of life in adulthood. Services that maintain functional skills and health throughout the lifespan are valued for their support of quality of life in adults with Rett syndrome.
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13. Wan B, Wang Z, Jung M, Lu Y, He H, Chen Q, Jin Y. Effects of the Co-occurrence of Anxiety and Attention-Deficit/Hyperactivity Disorder on Intrinsic Functional Network Centrality among Children with Autism Spectrum Disorder. Autism Res ;2019 (May 10)
Children with autism spectrum disorder (ASD) present with a high co-occurrence of anxiety and attention-deficit/hyperactivity disorder (ADHD). However, it remains unclear how the co-occurrence of anxiety and ADHD in children with ASD alters whole-brain functional networks. Here, we aimed to examine anxiety- and ADHD-related brain network centrality in children with ASD separately and their relationships with ASD symptoms. Clinical anxiety and ADHD levels in children with ASD, aged 6-13 years old, were assessed. Participants were categorized into four groups : ASD only (n = 28), ASD + anxiety (n = 19), ASD + ADHD (n = 25), and ASD + both anxiety and ADHD (n = 28). Subsequently, we compared voxel-wise network degree centrality (DC) among the four groups. We found that : (a) compared with ASD only, children with ASD + anxiety showed higher DC in the left middle temporal gyrus, right lingual gyrus, and left cuneus, and lower DC in the right precuneus ; (b) children with ASD + ADHD presented higher DC in the right calcarine and left superior frontal gyrus (SFG) compared with ASD only ; (c) children with ASD + both displayed higher DC in the right calcarine and lower centrality in the right middle occipital gyrus compared with ASD only ; and (d) across all children with ASD, there was a positive correlation between DC of the right calcarine with nonverbal behavior scores, and DC of the left SFG was negatively correlated with social scores. Our findings suggest that the right calcarine, left SFG, and default mode network nodes play important roles in the co-occurrence of anxiety and ADHD among children with ASD. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY : The co-occurrence of anxiety and attention-deficit/hyperactivity disorder (ADHD) has been shown to influence the brain function of children with ASD. In order to gain a better understanding of this, the present study compared degree centrality, the amount of effective brain functional connectivity that reflects the characteristics of brain networks, among four groups : ASD only, ASD + anxiety, ASD + ADHD, and ASD + both anxiety and ADHD. We found that some areas located in the language processing network and primary visual cortex were associated with the co-occurrence of ADHD, and some other areas located in the default mode network were associated with the co-occurrence of both anxiety and ADHD. These findings provide more knowledge about the neural basis underlying behavioral changes related to the co-occurrence of anxiety and ADHD in children with ASD.
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14. Wenhart T, Bethlehem RAI, Baron-Cohen S, Altenmuller E. Autistic traits, resting-state connectivity, and absolute pitch in professional musicians : shared and distinct neural features. Mol Autism ;2019 ;10:20.
Background : Recent studies indicate increased autistic traits in musicians with absolute pitch and a higher proportion of absolute pitch in people with autism. Theoretical accounts connect both of these with shared neural principles of local hyper- and global hypoconnectivity, enhanced perceptual functioning, and a detail-focused cognitive style. This is the first study to investigate absolute pitch proficiency, autistic traits, and brain correlates in the same study. Sample and methods : Graph theoretical analysis was conducted on resting-state (eyes closed and eyes open) EEG connectivity (wPLI, weighted phase lag index) matrices obtained from 31 absolute pitch (AP) and 33 relative pitch (RP) professional musicians. Small-worldness, global clustering coefficient, and average path length were related to autistic traits, passive (tone identification) and active (pitch adjustment) absolute pitch proficiency, and onset of musical training using Welch two-sample tests, correlations, and general linear models. Results : Analyses revealed increased path length (delta 2-4 Hz), reduced clustering (beta 13-18 Hz), reduced small-worldness (gamma 30-60 Hz), and increased autistic traits for AP compared to RP. Only clustering values (beta 13-18 Hz) were predicted by both AP proficiency and autistic traits. Post hoc single connection permutation tests among raw wPLI matrices in the beta band (13-18 Hz) revealed widely reduced interhemispheric connectivity between bilateral auditory-related electrode positions along with higher connectivity between F7-F8 and F8-P9 for AP. Pitch-naming ability and pitch adjustment ability were predicted by path length, clustering, autistic traits, and onset of musical training (for pitch adjustment) explaining 44% and 38% of variance, respectively. Conclusions : Results show both shared and distinct neural features between AP and autistic traits. Differences in the beta range were associated with higher autistic traits in the same population. In general, AP musicians exhibit a widely underconnected brain with reduced functional integration and reduced small-world property during resting state. This might be partly related to autism-specific brain connectivity, while differences in path length and small-worldness reflect other ability-specific influences. This is further evidenced for different pathways in the acquisition and development of absolute pitch, likely influenced by both genetic and environmental factors and their interaction.
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15. Zhang Y, Xiang Z, Jia Y, He X, Wang L, Cui W. The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism. Prog Neuropsychopharmacol Biol Psychiatry ;2019 (May 7):109644.
Autism spectrum disorders (ASDs) comprise a number of heterogeneous neurodevelopmental diseases. Recent studies suggest that the abnormal transmission of neural signaling pathways is associated with the pathogenesis of autism. The aim of this study was to identify a link between the Notch signaling pathway and the pathogenesis of autism. In this study, we demonstrated that prenatal exposure to valproic acid (VPA) resulted in autistic-like behaviors in offspring rats and that the expression of the Notch signaling pathway-related molecules Notch1, Jagged1, Notch intracellular domain (NICD) and Hes1 increased in the prefrontal cortex (PFC), hippocampus (HC) and cerebellum (CB) of VPA rats compared to those of controls. However, inhibiting the Notch pathway with (3,5-Difluorophenacetyl)-L-alanyl-S-phenylglycine-2-butyl Ester (Dapt) reduced the overexpression of Notch pathway-related molecules in offspring rats. Notably, Dapt improved autistic-like behaviors in a VPA-exposed rat model of autism. Furthermore, we investigated whether Dapt improved autistic-like behavior in a VPA rat model by regulating autophagy and affecting the morphology of dendritic spines. We found that the expression of the autophagy-related proteins Beclin 1, LC3B and phospho-p62 in the PFC, HC and CB of VPA model rats increased after Notch signal activation and was inhibited by Dapt compared to those of controls. Moreover, postsynaptic density-95 (PSD-95) protein expression also increased significantly compared to that of VPA model rats. The density of dendritic spines decreased in the PFC of VPA rats treated with Dapt compared to that of VPA model rats. Our present results suggest that VPA induces an abnormal activation of the Notch signaling pathway. The inhibition of excessive Notch signaling activation by Dapt can alleviate autistic-like behaviors in VPA rats. Our working model suggests that the Notch signaling pathway participates in the pathogenesis of autism by regulating autophagy and affecting dendritic spine growth. The results of this study may help to elucidate the mechanism underlying autism and provide a potential strategy for treating autism.