text:
- Research
- Open Access
Acidosis and acute kidney injury in severe malaria
- Natthida Sriboonvorakul1,
- Aniruddha Ghose5,
- M. Mahtab Uddin Hassan5,
- Md. Amir Hossain5,
- M. Abul Faiz5,
- Sasithon Pukrittayakamee1,
- Kesinee Chotivanich1,
- Yaowalark Sukthana2,
- Stije J. Leopold3, 4,
- Katherine Plewes3, 4,
- Nicholas P. J. Day3, 4,
- Nicholas J. White3, 4,
- Joel Tarning3, 4 and
- Arjen M. Dondorp3, 4Email author
© The Author(s) 2018
- Received: 13 December 2017
- Accepted: 14 March 2018
- Published: 23 March 2018
In severe falciparum malaria metabolic acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome in all age groups. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria.
Plasma and urinary acids which previously showed increased concentrations in proportion to disease severity in patients with severe falciparum malaria were quantified. Patients with uncomplicated malaria, sepsis and healthy volunteers served as comparator groups. Multiple regression and multivariate analysis were used to assess the relationship between organic acid concentrations and clinical syndromes, in particular AKI.
Patients with severe malaria (n = 90), uncomplicated malaria (n = 94), non-malaria sepsis (n = 19), and healthy volunteers (n = 61) were included. Univariate analysis showed that both plasma and creatinine-adjusted urine concentrations of p-hydroxyphenyllactic acid (pHPLA) were higher in severe malaria patients with AKI (p < 0.001). Multiple regression analysis, including plasma or creatinine-adjusted urinary acids, and PfHRP2 as parasite biomass marker as independent variables, showed that pHPLA was independently associated with plasma creatinine (β = 0.827) and urine creatinine (β = 0.226). Principal component analysis, including four plasma acids and seven urinary acids separated a group of patients with AKI, which was mainly driven by pHPLA concentrations.
Both plasma and urine concentrations of pHPLA closely correlate with AKI in patients with severe falciparum malaria. Further studies will need to assess the potential nephrotoxic properties of pHPLA.
- Severe malaria
- Acidosis
- Acute kidney injury
Severe malaria caused by Plasmodium falciparum remains a major cause of death in the tropics, with an estimated 429,000 deaths in 2015 [1]. The major manifestations of severe malaria, which independently predict fatal outcome in both adults and children, include coma (cerebral malaria), acidosis and renal dysfunction [2–5]. Coma in cerebral malaria is characterized by an absence of localizing neurological signs, and full recovery in most adults and the majority of children if patients survive. Acidosis in severe malaria is primarily a lactic acidosis, resulting from anaerobic glycolysis as a result of microcirculatory impairment caused by sequestered parasitized red cells. This is compounded by reduced hepatic lactate clearance [6]. But lactic acid comprises less than half of the acid load, whereas these incompletely characterized additional acids are an independent prognosticator for a fatal outcome [7]. Acute kidney injury (AKI) is common in adult severe malaria, and may be under-recognized in paediatric patients [8, 9]. The pathology of AKI is characterized by acute tubular injury, associated with an accumulation of parasitized red cells and mononuclear cells in the glomerular and peritubular capillaries with a contribution of haem-mediated oxidative damage [10–12]. Metabolic acidosis and AKI are interrelated, since renal dysfunction causes accumulation of acids normally excreted or metabolized by the kidney. Indeed, in severe malaria plasma creatinine is an independent predictor of acidosis [6]. The plasma concentration of an acid, or other biomarkers of severity may therefore reflect either increased production, reduced clearance or both. Adjusting the plasma concentration for plasma creatinine only corrects for concomitant renal dysfunction if the acid or biomarker has similar renal clearance dynamics as creatinine, including similar renal filtration, re-absorption and secretion. For many biomarkers these properties have not been assessed.
The current study reports a secondary data analysis on plasma and urine organic acids elevated in adult patients with falciparum malaria and sepsis [13, 14], and relates these to organ failure in severe malaria, in particular AKI.
Patients and sample collection
Details of the study have been described previously in detail [13, 14]. Written informed consent was obtained from all participants in the study or from their attending relative for incapacitated patients. Consecutive adult patients with slide-proven severe falciparum malaria admitted at Chittagong Medical College Hospital, Chittagong, Bangladesh, were recruited in the study. Pregnant women were excluded from the study. In addition, a sub-set of Bangladeshi patients with other sepsis syndromes with acidosis and with uncomplicated falciparum malaria were included in the study. In addition, a group of healthy controls were recruited from the local population, screened by a physical exam and basic laboratory testing.
Severe malaria was classified by modified World Health Organization (WHO) criteria [15]. AKI was defined by a plasma creatinine > 265 μmol/l, coma as a Glasgow Coma Score (GCS) < 11 and a high parasite biomass by a plasma concentration of P. falciparum histidine-rich protein 2 (PfHRP2) > 1000 ng/ml [16].
Non-malaria sepsis was defined by a blood film negative for malaria of all species, clinical suspicion of bacterial infection, based on history, examination and, when available, complete blood count and other investigations, a standard base deficit (SBD) ≥ 3 mEq/l and 2 or more of the following four criteria: (1) heart rate > 90 beats per minute; (2) respiratory rate > 20 breaths per minute; (3) systolic blood pressure < 90 mmHg; and/or, (4) GCS score < 15. Recruitment in this study was prior to the recently adopted updated criteria for sepsis [17].
Healthy volunteers were screened by microscopy for absence of Plasmodium parasites. Ethical approval for this observational study was provided by the Chittagong Medical College Hospital Ethical Review Committee and the Oxford Tropical Research Ethics Committee.
Analytical methods
Peripheral blood parasitaemia was assessed by microscopy from peripheral blood slides stained according to Field's method. Plasma PfHRP2 concentration was assessed by a commercial sandwich enzyme-linked immunosorbent assay kit (ELISA) (Cell Labs, Brookvale, Australia), as described previously [19].
Plasma PfHRP2, released by the parasitized red blood cell at schizont rupture, is a surrogate measure of the total body parasite biomass, which includes the sequestered biomass [19].
Statistical methods
Plasma and corrected urine acid concentrations were log-normalized. Acid concentrations were compared initially between disease groups and disease manifestations. The four groups (severe malaria, uncomplicated malaria, non-malaria sepsis, healthy) were compared by analysis of variance (ANOVA). Student's t test was used where only two participant groups were compared. Multiple regression models were assessed for plasma and urinary acids, PfHRP2 as independent variables, and plasma or urinary creatinine as dependent variable. For the multiple regression analysis, acid concentrations were log-transformed toward normality before analysis. All variables in univariate analysis were initially included in the model then backward stepwise selection was performed, removing variables with α ≥ 0.05 and using optimal value of Akaike's information criterion (AIC) and Bayesian information criterion (BIC) in the model.
Further multivariate statistical analyses relating acid concentrations to disease states included principal component analysis (PCA) and partial least square discrimination analysis (PLSDA). PCA analysis was used to visualize clustering for specific disease profiles, including presence of AKI, coma and parasite biomass. PLSDA analysis was then used to create prediction models to classify unknown samples.
Analyses were performed with STATA/IC 12.0 software (StataCorp, College Station, TX, USA), MATLAB version 7.11 software (MathWorks, Natick, MA, USA) and GraphPad PRISM® version 5.03 (GraphPad Software Inc, CA, USA).
Patient characteristics and univariate analysis
Baseline clinical and laboratory
Severe malaria
Uncomplicated malaria N = 94
N = 61d
p value
Male, n (%)
63 (70%)
74 (79%)
9 (47%)
Age (year)*
32 (25–45)
29 (21–45)
35 (25–48)
Glasgow Coma Scale score*
10 (8–14)
15 (15–15)
14 (8–15)
< 0.001
GCS score < 11, n (%)
59/90 (66%)
0 (0%)
6/19 (32%)
Parasitaemia (count/μl)
41,929 (26,191–67,127)
10,287 (5959–17,758)
< 0.001
PfHRP2 (ng/ml)
1740 (1333–2272)
240.3 (167.8–344.1)
< 0.001
Total bilirubin (mg/dl)
2.8 (2.3–3.5, 0.2–44.2)
1.1 (0.9–1.4, 0.2–28.3)
0.94 (0.59–1.49)
< 0.001
Creatinine (mg/dl)
1.48 (1.34–1.65)
0.95 (0.89–1.01)
1.68 (1.25–2.26)
< 0.001
Acute kidney injury (creatinine > 3 mg/dl), n (%)
13/90 (14%)
0/94 (0%)
4/19 (21%)
Plasma concentration (μmol/l)a
4587 (4028–5223)
2246 (2080–2426)
2849 (2148–3779)
1111 (1088–1133)
< 0.001
118.7 (106–133)
63.07 (56.58–70.3)
107.7 (86.2–134.6)
22.18 (21.19–23.21)
< 0.001
139.0 (126.1–153.1)
101.9 (91.28–113.7)
247.9 (160.4–383.2)
71.37 (69.43–73.37)
< 0.001
9.73 (8.51–11.11)
5.85 (5.57–6.15)
8.24 (6.97–9.73)
1.06 (0.99–1.14)
< 0.001
Corrected urine concentrations (μmol/mmol CrCl)a, b
9.94 (7.54–13.09)
2.85 (2.32–3.49)
13.82 (4.76–40.1)
< 0.001
0.95 (0.73–1.25)
0.63 (0.51–0.78)
1.07 (0.55–2.09)
2.56 (2.17–3.03)
1.88 (1.57–2.26)
4.61 (2.13–9.96)
1.42 (1.09–1.86)
0.48 (0.34–0.66)
0.83 (0.30–2.29)
< 0.001
0.14 (0.12–0.17)
0.23 (0.19–0.28)
0.15 (0.11–0.22)
< 0.001
0.21 (0.17–0.25)
0.34 (0.27–0.43)
0.32 (0.21–0.48)
2.44 (2.09–2.85)
2.16 (1.89–2.47)
4.31 (2.77–6.70)
< 0.001
Urine concentrations (μmol/l)c
560.0 (436.3–718.7)
166.8 (140.0–198.7)
370.7 (196.7–698.7)
247.6 (221.1–277.2)
< 0.001
56.58 (44.39–72.12)
35.97 (29.98–43.16)
35.44 (23.43–53.59)
90.71 (80.0–102.8)
< 0.001
159.4 (142.2–178.7))
127.0 (114.4–140.9)
252.3 (168.7–377.3)
122.1 (115.3–129.2)
74.98 (60.85–92.40)
26.31 (20.73–33.40)
28.57 (17.75–45.97)
21.76 (16.29–29.08)
< 0.001
10.19 (8.51–12.20)
13.32 (11.20–15.84)
6.99 (4.53–10.79)
24.25 (20.79–28.28)
< 0.001
13.22 (10.63–16.45)
19.70 (15.83–24.52)
11.79 (7.51–18.53)
45.34 (36.54–56.26)
< 0.001
218.0 (201.5–235.9)
220.8 (201.9–241.4)
250.1 (190.8–327.8)
< 0.001
Plasma and urine concentrations of organic acids detected in patients with severe malaria with or without acute kidney injury (AKI)
Severe malaria
Severe malaria
p value
with AKI (N = 13)
without AKI (N = 77)
Plasma concentration (μmol/l)a
6406 (4816–8520)
4335 (3760–4998)
142 (107–188)
115 (102–131)
178 (133–238)
133 (120–148)
33.8 (22.5–50.7)
7.88 (7.36–8.45)
< 0.001
Urine creatinine adjusted concentrations (μmol/mmol CrCl)a, b
50.7 (30.4–84.5)
7.55 (5.78–9.86)
< 0.001
1.33 (0.86–2.06)
0.90 (0.66–1.22)
5.94 (4.52–7.80)
2.22 (1.87–2.64)
< 0.001
8.80 (6.17–12.5)
1.04 (0.82–1.33)
< 0.001
0.11 (0.07–0.17)
0.15 (0.12–0.18)
0.16 (0.09–0.25)
0.22 (0.18–0.27)
7.29 (6.28–8.46)
2.03 (1.76–2.33)
< 0.001
800 (451–1420)
527 (400–696)
21.0 (13.7–32.3)
67.0 (51.8–86.8)
101 (86.0–120)
172 (152–194)
139 (102–189)
67.6 (53.6–85.2)
3.21 (2.59–3.98)
11.2 (9.38–13.4)
3.58 (2.42–5.30)
15.4 (12.4–19.1)
242 (213–275)
218 (201–237)
The (log) plasma concentrations of pHPLA correlated with (log) plasma concentrations of PfHRP2, (r = 0.57, p < 0.001). The (log) corrected urine concentration of pHPLA also correlated with plasma PfHRP2 (r = 0.38, p < 0.001), whereas the unadjusted pHPLA urine concentrations did not (r = -0.024, p = 0.835). The (log) plasma concentrations of pHPLA also correlated with the (log) plasma total bilirubin concentrations (r = 0.46, p < 0.001).
Multiple regression and multivariate analysis
In patients with severe malaria, applying linear multiple regression models with (log) plasma creatinine as dependent variable, including plasma acids (LA, αHBA, βHBA, pHPLA) and plasma PfHRP2 as marker for total parasite burden as independent variables, plasma pHPLA and LA were retained in the model (Additional file 1: Table S2). In the model, pHPLA was associated most strongly with plasma creatinine (β = 0.827).
In patients with sepsis, linear regression models with (log) plasma creatinine as dependent variable, including plasma acids (LA, αHBA, βHBA, pHPLA) as independent variables (Additional file 1: Table S3), only the (log) plasma pHPLA concentration was correlated with the (log) plasma creatinine (r = 0.26, p = 0.007) and plasma pHPLA was associated most strongly with plasma creatinine, with β = 0.849, Plasma LA, αHBA and βHBA did not show a correlation.
In patients with severe falciparum malaria the concentrations of several small organic acids are increased compared to patients with uncomplicated malaria and healthy controls. Apart from lactic acid, concentrations of pHPLA, αHBA and βHBA in plasma and pHPLA, αHBA, βHBA, MMA, EMA, and αKGA in urine are all elevated [14]. In this secondary analysis the relationships between these acid concentrations and specific organ involvement, in particular AKI, were assessed in more detail.
Increased concentrations of plasma LA, βHBA and pHPLA were observed in severe malaria patients with AKI compared to patients without AKI. The main source of plasma lactate in severe malaria is from anaerobic glycolysis in the human host caused by blockage of the microcirculation by sequestered parasitized red blood cells and compounded by reduced hepatic clearance [6, 7, 20]. Plasmodium falciparum parasites also produce lactate, but this is thought to be a minor contribution to the total lactate concentration [7]. Plasma lactate and AKI both have strong prognostic significance for death in severe malaria.
Urinary lactate concentrations were also increased in severe malaria patients with AKI. In healthy subjects, creatinine has limited tubular re-absorption and negligible tubular secretion, whereas lactate is fully filtered by the glomerulus [21] and then almost completely re-absorbed in the proximal tubule [21]. Tubular re-absorption of lactate might be disturbed in severe malaria patients with AKI, characterized by acute tubular injury. Increased renal production of lactate is another possible contributor, related to the extensive sequestration of parasitized red blood cells in renal vessels, shown in post-mortem autopsy studies of severe malaria-related AKI [11], whereas the medulla of the kidney is already scarcely vascularized.
βHBA is a ketoacid generated from human free fatty acid metabolism, which becomes an energy source during fasting, dysregulated type I diabetes, and other disease states. Patients with severe malaria have usually been fasting for an extended period, and there is a high metabolic demand related to the severe febrile illness. As previously shown, plasma concentrations of βHBA are elevated in severe falciparum malaria, provided ketogenesis has not been suppressed by quinine-induced insulin secretion, and correlate well with plasma creatinine concentrations (r = 0.68, p = 0.001) [14, 22–24].
Ketogenesis can also occur in the kidney, which might contribute to the increased urine concentrations of βHBA adjusted for plasma and urinary creatinine concentrations.
In the present study, an increase in both plasma and urinary concentrations of pHPLA in patients with severe malaria was shown, strongly correlating with the presence of AKI. This indicates that pHPLA production is increased in these patients, although reduced hepatic clearance could also have contributed. The renal handling of pHPLA has not been well characterized, so it cannot be excluded that the increased urine concentrations are explained by reduced renal tubular re-absorption of glomerular-filtered pHPLA. Local renal production of pHPLA is an alternative explanation. pHPLA is derived from p-hydroxyphenylpyruvic (pHPPA) acid and a product in the phenylalanine and tyrosine pathways. Plasma phenylalanine (an indirect precursor of pHPPA) has shown to be increased in adult patients with severe malaria [25]. Both the human host and P. falciparum produce pHPLA (Human Metabolome Database (HMDB) [26]. The human gut flora produces the d-isomer of pHPLA, and is thus another potential source. The LC–MS method used in the current study cannot distinguish between d and l-form isomers. Plasma PfHRP2 and pHPLA concentrations were correlated and might suggest P. falciparum as a potential source of pHPLA in patients with severe malaria. However, a positive correlation with PfHRP2 may also reflect increased sequestration in the gut microvasculature, causing increased translocation of gut microbioma and their products.
In the PCA analysis, pHPLA was a strong driver for clustering on the PC2 axis patients with AKI, which was confirmed by PLSDA analysis. pHPLA remained a significant driver separating the patients with AKI, even when creatinine was added as a variable in the PCA analysis. The results suggest that pHPLA is not merely a biomarker for AKI, but also could contribute to renal dysfunction in patients with severe falciparum malaria. The pathogenesis of AKI in severe malaria is multifactorial. Free haemoglobin associated oxidative damage to the renal tubules is thought to be an important contributor [10]. In a large autopsy series, microvascular sequestration of parasitized red blood cells in the peritubular capillaries is observed, which could impair the already vulnerable circulation of the renal medulla. Locally parasite-produced pHPLA could be an additional contributor to renal tubular injury. In patients with tyrosinemia, pHPLA accumulates, and renal tubular damage is common in this disease [27]. In addition, pHPLA has been implicated as a cause of tubular damage in Fanconi syndrome, although alternative mechanisms have also been proposed [28]. Assessment of the sources of pHPLA in severe falciparum malaria, and its contribution to renal damage will need further investigation, including animal studies, metabolomic studies in P. falciparum, and detailed kinetic studies in patients, distinguishing the l- and d-isomers of pHPLA.
Limitations of the study include the focus on a limited number of acids selected by the column used for extraction. Although during the development phase several columns were compared [13], it cannot be excluded that additional contributing small organic acids have been missed. The number of sepsis patients was limited in this study, and the causing microorganisms were not identified, because of the limited local diagnostic capacity. This precludes drawing firm conclusions in this patient group. In addition, 24-h urines were not collected in the study, so that the total quantity of excreted acids could not be estimated accurately. Correcting the urine acid concentration for urine creatinine concentration partly circumvents this problem, but assumes similar renal clearance mechanisms of these compounds.
This secondary analysis of organic acid concentrations in patients with falciparum malaria shows that both plasma and urine concentrations of pHPLA are independently correlated with AKI, suggesting a possible causative contribution of pHPLA to AKI. This hypothesis will now need further testing.
Authors' contributions
NS and AMD drafted the manuscript. NS and JT devised and performed LC–MS analyses. NS, JT and ADM devised and performed chemometrics. NJW, NPJD, JT, and AMD conceived of the study. AMD, AG, SM, MMUH, MAH, MAF, SM, SJL, and KP provided clinical sample, data collection and input on the analysis. AMD, NW, NPJD, JT, SP, KC, and YS supported all work and interpretation data. All authors read and approved the final manuscript.
Special thanks to The Thailand Research Fund, Office of the Higher Education Commission and Mahidol University (MRG5980038). This study was part of the Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme supported by the Wellcome Trust. Sincere appreciation is expressed to Assist. Prof. Dr. Kanet Wongravee for Chemometrics advice and Atthanee Jeeyapant for statistical advice.
Competing interests
The authors declare that they have no competing interests.
Availability of data and materials
Not applicable.
Consent for publication
Not applicable.
Ethics approval and consent to participate
Ethical approval for this observational study was provided by the Chittagong Medical College Hospital Ethical Review Committee and the Oxford Tropical Research Ethics Committee.
The Thailand Research Fund, Office of the Higher Education Commission and Mahidol University (MRG5980038) and the Wellcome Trust of Great Britain [Grant Number 089275/Z/09/Z].
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Authors' Affiliations
- WHO. World malaria report. Geneva: World Health Organization; 2016.Google Scholar
- White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM. Malaria. Lancet. 2013;383:723–35.View ArticlePubMedGoogle Scholar
- Dondorp AM, Lee SJ, Faiz MA, Mishra S, Price R, Tjitra E, et al. The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis. 2008;47:151–7.View ArticlePubMedGoogle Scholar
- Von Seidlein L, Olaosebikan R, Hendriksen IC, Lee SJ, Adedoyin OT, Agbenyega T, et al. Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. Clin Infect Dis. 2012;54:1080–90.View ArticleGoogle Scholar
- Sypniewska P, Duda JF, Locatelli I, Althaus CR, Althaus F, Genton B. Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis. BMC Med. 2017;15:147.View ArticlePubMedPubMed CentralGoogle Scholar
- Day NP, Phu NH, Mai NT, Chau TT, Loc PP, Chuong LV, et al. The pathophysiologic and prognostic significance of acidosis in severe adult malaria. Crit Care Med. 2000;28:1833–40.View ArticlePubMedGoogle Scholar
- Dondorp AM, Chau TTH, Phu NH, Mai NTH, Loc PP, Chuong LV, et al. Unidentified acids of strong prognostic significance in severe malaria. Crit Care Med. 2004;32:1683–8.View ArticlePubMedGoogle Scholar
- Trang TT, Phu NH, Vinh H, Hien TT, Cuong BM, Chau TT, et al. Acute renal failure in patients with severe falciparum malaria. Clin Infect Dis. 1992;15:874–80.View ArticlePubMedGoogle Scholar
- Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, et al. Acute kidney injury is common in pediatric severe malaria and is associated with increased mortality. Open Forum Infect Dis. 2016;3:046.Google Scholar
- Plewes K, Kingston HWF, Ghose A, Maude RJ, Herdman MT, Leopold SJ, et al. Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study. BMC Infect Dis. 2017;17:313.View ArticlePubMedPubMed CentralGoogle Scholar
- Nguansangiam S, Day NP, Hien TT, Mai NT, Chaisri U, Riganti M, et al. A quantitative ultrastructural study of renal pathology in fatal Plasmodium falciparum malaria. Trop Med Int Health. 2007;12:1037–50.View ArticlePubMedGoogle Scholar
- Plewes K, Royakkers AA, Hanson J, Hasan MM, Alam S, Ghose A, Maude RJ, et al. Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria. Malar J. 2014;13:91.View ArticlePubMedPubMed CentralGoogle Scholar
- Sriboonvorakul N, Leepipatpiboon N, Dondorp AM, Pouplin T, White NJ, Tarning J, et al. Liquid chromatographic-mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;941:116–22.View ArticlePubMedPubMed CentralGoogle Scholar
- Herdman MT, Sriboonvorakul N, Leopold SJ, Douthwaite S, Mohanty S, Hassan MM, et al. The role of previously unmeasured organic acids in the pathogenesis of severe malaria. Crit Care. 2015;19:317.View ArticlePubMedPubMed CentralGoogle Scholar
- Tran TH, Day NP, Nguyen HP, Nguyen TH, Tran TH, Pham PL, et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med. 1996;335:76–83.View ArticlePubMedGoogle Scholar
- Hendriksen IC, Mwanga-Amumpaire J, von Seidlein L, Mtove G, White LJ, Olaosebikan R, et al. Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement. PLoS Med. 2012;9:1001297.View ArticleGoogle Scholar
- Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–10.View ArticlePubMedPubMed CentralGoogle Scholar
- Charunwatthana P, Abul Faiz M, Ruangveerayut R, Maude RJ, Rahman MR, Roberts LJ, et al. N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial. Crit Care Med. 2009;37:516–22.View ArticlePubMedPubMed CentralGoogle Scholar
- Dondorp AM, Desakorn V, Pongtavornpinyo W, Sahassananda D, Silamut K, Chotivanich K, et al. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med. 2005;2:204.View ArticleGoogle Scholar
- Pukrittayakamee S, Krishna S, Ter Kuile F, Wilaiwan O, Williamson DH, White NJ. Alanine metabolism in acute falciparum malaria. Trop Med Int Health. 2002;7:911–8.View ArticlePubMedGoogle Scholar
- Hohmann B, Frohnert PP, Kinne R, Baumann K. Proximal tubular lactate transport in rat kidney: a micropuncture study. Kidney Int. 1974;5:261–70.View ArticlePubMedGoogle Scholar
- White NJ, Warrell DA, Chanthavanich P, Looareesuwan S, Warrell MJ, Krishna S, et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med. 1983;309:61–6.View ArticlePubMedGoogle Scholar
- White NJ, Miller KD, Marsh K, Berry CD, Turner RC, Williamson DH, et al. Hypoglycaemia in African children with severe malaria. Lancet. 1987;1:708–11.View ArticlePubMedGoogle Scholar
- Sasi P, English M, Berkley J, Lowe B, Shebe M, Mwakesi R, et al. Characterisation of metabolic acidosis in Kenyan children admitted to hospital for acute non-surgical conditions. Trans R Soc Trop Med Hyg. 2006;100:401–9.View ArticlePubMedGoogle Scholar
- Lopansri BK, Anstey NM, Stoddard GJ, Mwaikambo ED, Boutlis CS, Tjitra E, et al. Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications. Infect Immun. 2006;74:3355–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Park YH, Shi YP, Liang B, Medriano CA, Jeon YH, Torres E, et al. High-resolution metabolomics to discover potential parasite-specific biomarkers in a Plasmodium falciparum erythrocytic stage culture system. Malar J. 2015;14:122.View ArticlePubMedPubMed CentralGoogle Scholar
- Sun MS, Hattori S, Kubo S, Awata H, Matsuda I, Endo F. A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice. J Am Soc Nephrol. 2000;11:291–300.PubMedGoogle Scholar
- Andreoli TE, Fanestil DD, Hoffman JF, Schultz S. Clinical disorders of membrane transport processes. US: Springer; 2012.Google Scholar
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.


text: Make sure you are ready to get your seeds planted before spring begins. Hyacinth are a spring flowering bulb that have long and narrow leaves with highly fragrant flowers with beautiful coloring. But before you start getting the holes ready, make sure you read through some of these facts first.Hyacinth History Hyacinths have been a […]Continue reading

subset: commoncrawl


text:
Our theme for the 2016-2017 school year, "Living in Community," comes from Colossians 3:12-17. Each month our Scripture memory will be focused on our theme for the year. In addition to monthly Scripture memory, we also have longer passages of Scripture for the fall and spring. Our fall Scripture focuses on the birth of Christ. Our spring Scripture focuses on the resurrection of Christ.
At Covenant, we memorize and reinforce Scripture as a community in order to encourage families to learn the memory verses together. We recognize that younger children may only memorize a portion of the passage. Each teacher will set expectations regarding the memory work for their class. Our prayer is that our students will place God's Word deep in their hearts. In addition to Scripture, we also formally memorize our school hymn, Amazing Grace, and as we go through the year we will seek to memorize the first verse or two of several other hymns.
Download our Scripture Memory PDF here.


text:
Why are people so mad at Game of Thrones?
- Published: 14 May 2019
- The final season of Game of Thrones, and especially the last 3 episodes, have divided and angered many fans of the show. But why? Well, there are a number of reasons for this, so let's break down the biggest and most recent problem first - Daenerys.
In last night's episode, Daenerys and Drogon rain fire down upon King's Landing, killing thousands of innocents. This is all after Cersei's armies have surrendered. Now the show's writers justify this by claiming it's the Mad King storyline coming full circle with his daughter. And, if the show had more episodes and time to develop this extreme choice, it could have made more sense. But we're only given 6 episodes this season, as opposed to the usual 10, and the decision to make Daenerys the "Mad Queen" seems rushed and hasty.
Throughout the seasons, we've seen Daenerys promise she's nothing like her father, as she's freed slaves and ruled mostly benevolently. So last night's episode largely felt like a betrayal to both fans and her very character. An entire city going up in flames makes for a great visual, sure, but narratively it's questionable. Now it appears Daenerys is the show's "Big Bad," and not Cersei.
And that's another big problem - Cersei and her fate. Fans were out for blood and wanted a gruesome end for the cold-hearted tyrant. But instead of getting a knife in the heart (like many predicted), she fell victim to rubble. Now one could argue that Daenerys ultimately killed Cersei...but her end still seems somewhat anticlimactic. And that doesn't even begin to address Jaime's problem.
Jaime's redemption arc - where'd it go?! The Lannister most changed from a character standpoint after years of questioning his actions and his loyalty to his lover went back to his old ways all too quickly. In the previous episode, after leaving Brienne, fans had hoped he was on his way to King's Landing just to finish Cersei off himself. But this latest episode proved - NOPE! - he just wanted one last cuddle with his sister-lover. Hm.
In conclusion, we only have 1 episode left, and frankly I'm excited to see where this all goes.
GREEN SCREEN VERSION: blog-rank.info/user/watch?v=SZwkU6egd8M
- Fun
Comments • 5 503
- alien sauce 56 minutes back
The actual script is in the description and he actually filmed himself saying the script, just a lil' spice of EndGame
- 7452 2 hours back
Someone got a new green screen
- melting crayon 2 hours back
I knew I should've stopped when the mini Jack appeared, yet I stayed and watched the full thing anyway.
- living_dead_guy_222 3 hours back
Game of thrones is actually for stupid people.
- JJ Plays 5 hours back
How does jack have 4.5 million subscribers
I mean *only* have 4.5
- Luis Gonzalez 9 hours back
You are a loser
- Ivan Lamparelli 12 hours back
You forgot about the night king. What the f*** was the whole point of the army of the dead?
- Marina Knežević 13 hours back
The most anoying video i have ever watched
- some guy with no life 14 hours back
Sorry jack i watched endgame and i didnt like it
- robert powers 18 hours back
have you seen endgame yet?
- Entitled Vegetables 19 hours back
When all ur friends have seen endgame and you have yet to see it
- Michael Johnson 22 hours back
Next!...Game of Thongs.
- Gurveen 23 hours back
why do i even watch ur videos anymore lmao
- Dasha Young 23 hours back
I left this in my watch later only to find this....
- Damian Smith 24 hours back
Sweet baby Lucifer this is an audio nightmare
- Grim Sleeper 2 days back
The only thing worse than game of throws and end lame is your gay ass.
- fynn bearfoot 2 days back
like a horrific snake
- Kactusman 2 days back
I love how he gets progressively sweatier the more layers there are.
- veikka toivari 2 days back
A lightswitch
- Garrick Vachs 2 days back
For some reason this felt way longer than a minute and 50 seconds...
- Jiggly Jayden 2 days back
who is endgame, what the hell
- Tv and Ev epic vids 2 days back
Did anyone else notice that little jab to tell us to watch endgame
- FabolousNupe 2 days back
- Badger DragonInc. 2 days back
This is the 15th time I'm watching this
- Santiago Rodriguez Guillen 2 days back
In title brats that can't watch something without whining
- Proillyyasin 2 days back
- Filipe's morning of gaming 2 days back
What a good point
- DAJOKER808 2 days back
Are you sweating ?
- churg err 2 days back
Headache achieved
- Kuroemii 2 days back
Hold up is that Alix?
- Bill Gates 3 days back
I was too focused on thanos dancing
- ZACH R 3 days back
What did I just download,,,,so many pop up ads
- Normantas 3 days back
No sponsor?
- Jordan Ortiz 3 days back
You are the worst youtuber
- Gael epic channel of awsomness 3 days back
Wtf? youtube JUST TODAY SEND ME THIS NOTIIFCATION TF YOU TUBE
- emma jemma 3 days back
i get jumpscared every time he says "did you see endgame yet" like wtf
- Shaggy Rogers 3 days back
Endgame of thrones
- Adrianne Kok 3 days back
this physically hurt to watch
- Teal Squid 3 days back
all very valid reasons
- Henrik Opheim Hegre 3 days back
I haven't seen any of the infinity wars movies yet. What order and should I view them in? Long fighting scenes makes me dizzy, so I will probably watch the movies half speed to keep score of who punches who and where. Do I have time to watch all the movies half speed before Thongus pull the plug on the universe?
- Wilfredo Ramos 3 days back
What. A. Madlad.
- Yo Bro 3 days back
I watched Endgame last night
- Bincy John 3 days back
Well this made me mad at him
- MYSTER 3 days back
Daenerys spent the entire series rationalizing butchering anyone who crossed her or hurt others because "they deserved it." The only difference between butchering your enemies and butchering innocents is whether or not you can justify seeing those innocents as your enemies. Which she did. She was quite clear the entire time that she felt the people were siding with Cersei and she was infuriated that they only surrendered after things were clearly not going their way instead of before her friend was murdered and one of her dragons killed. She hates those people and sees them as weak and cowardly and people and creatures she loved died because of them. As far as her fucked up mind is concerned they are her enemies and she's doing what she always does to her enemies: making a brutal and swift example of them so no one will ever cross her again. And just like every other time she won't feel bad at all because she's always willing to rationalize her butchery. She's a fanatic who's presently paranoid and barely holding herself together after seasons of her barely being held back by anyone else as it was. She likes to say she's doing what she does for noble reasons but it's always just been a rationalization for her.
She is driven by greed of power and materialism, being so, non of her murders can be justify. Her comfort zone was recently destroyed and that lead to her loosing control, showing her true self in all of her glory.
This has been, if anything, her most consistent character trait throughout and the only thing that ever held her back at all before were her trusted advisors. Now her trusted advisors are either all dead or people she no longer trusts and thinks are actively plotting against her.
- Brendon 69 4 days back
Congratulations! You found the most recent comment in the ocean of 5.4k comments!
- Mel 4 days back
I haven't even seen Infitity War let me breathe Jack
- die - you tried 4 days back
hey can you turn my ad blocker back on I can't hear the video.............
- Hayden Minish 4 days back
Okay and a woah


text:
Worldwide Campaign to stop the Abuse and Torture of Mind Control/DEWs
27 members69 Comments 4 Likes
Started this discussion. Last reply by Sue May 30, 2018. 10 Replies 0 Likes
My electronic harassers utilize physical pain as part of their torture on a fairly regular basis. I get pain all over my entire body and then start to shake uncontrollably and am forced to sit on my…Continue
sandy boewer has not received any gifts yet
© 2019 Created by Soleilmavis. Powered by


text:
HR Professional speaks with leadership and wellness coach Gail Voisin on how to think (way) beyond programs for a healthier, happier and more productive workforce
By Melissa Campeau
Many organizations will spend hundreds of thousands of dollars on developing and implementing corporate wellness only to be faced with waning enthusiasm and interest just a short while down the road. That's a huge missed opportunity since wellness, when done right and effectively sustained, boosts employees' overall health and helps an organization save money and reap greater profits.
What's missing in many cases is a holistic approach to wellness. According to an Ivey Business School report published in 2015 (see sidebar), there are several big-picture factors critical for the success of corporate wellness. They include business strategy alignment, a supportive environment and organizational culture.
Gail Voisin, executive leadership and lifestyle/wellness coach, quite literally wrote the book on this subject (All Together Now: Vision, Leadership and Wellness) – four years before the Ivey Business School published their research results. Voisin's model is unique and makes the case that by aligning vision, leadership and wellness, both personally and organizationally, leaders naturally position themselves and their businesses to achieve extraordinary success.
HR Professional recently caught up with Voisin to learn more about how organizations can make effective, sustainable wellness happen.
How do you define personal wellness?
Gail Voisin: I would define it as having a healthy mind and body that can consistently sustain the energy reserves you need – not just to navigate the day to day, but also to meet exceptional circumstances beyond your control, both in business and family life.
Why should organizations make employees' wellness a priority?
GV: Wellness sustains performance and sets employees up for extraordinary success. It's like nudging the rudder of a large ship; just a small change can make a dramatic improvement in life's long-term course.
What roles do leaders play in corporate wellness?
GV: Leaders have both a personal and organizational role to play. Often part of the magic to make corporate wellness stick is in the behaviour modelling of the leaders. Personally, they need to make wellness a lifestyle habit and model these behaviours. Organizationally, they need to promote and support the corporate wellness values in the organization. Whether they realize it or not, leaders help organizations and employees set boundaries because their actions define what wellness means to the organization.
Some examples of how leaders can help set organizational boundaries are when they or their employees are pulled in many different directions by competing obligations. Leaders need to help establish boundaries between work and home life, their social life, sports and hobbies. Organizations with strong corporate wellness values will have leaders who follow protocols to help with this, particularly around the use of mobile phones and other portable communication devices.
This technology certainly has its place – making communication more efficient and instantaneous, especially for those whose positions require frequent travel. However, the expectation shouldn't be that an employee is therefore available 24/7, since this runs counter to the concepts of individual wellness and work-life integration. These devices can promote a culture of workaholism which isn't sustainable, either individually or organizationally, especially given the value and beliefs of many of the current generation and virtually all of the next generation of leaders.
What areas can an organization consider addressing to better support organizational wellness?
GV: There's no one-size-fits-all answer. However, it starts with ensuring leaders are trained on the importance of wellness so they can develop their own wellness strategies to be prepared to foster a culture that promotes wellness among their employees.
Best practices include solid health benefits, including a fitness centre or subsidized fitness program, employee assistance programs, training and development, career transition assistance if an employee is downsized and so on. This type of support helps take both leaders and staff members to a whole new quality of life in sustaining wellness.
To make Canada's Top 100 employers list, organizations are rated on the basis of eight different categories: Physical workspace; work atmosphere and social; health, financial and family benefits; vacation and time off; employee communications; performance management; training and skills development; and community involvement. These categories are a good match for what most employees look for in organizational wellness.
What role does stress management play in organizational wellness?
GV: How employees are able to manage stress is an important aspect of wellness. The harsh reality is that a great majority of our illnesses are stress related. Dr. Dean Ornish has done more than three decades of research demonstrating that comprehensive changes to lifestyle can begin to reverse even severe health problems without drugs or surgery. He points out that stress causes your arteries to constrict. It can cause arterial blockages to build up faster, your heart to beat irregularly and blood clots to form that can cause a heart attack.
The good news: It's not the stressors that are important so much as how you react to them. If you practice some simple stress management techniques you can be in the same job, in the same environment and not have it affect you in the same way.
That's important because when employees are highly stressed it can lead to more absenteeism, sickness and medical drugs, and eventually to short-term disability, long-term disability and so on. Healthy employees who can effectively manage their stress require fewer dollars spent on their health and benefit programs. By integrating wellness into an organization, it helps employees to gradually change unhealthy behaviours, which can lead not only to reduced health-care costs, but also a healthier and more productive workforce.
In your book, you emphasize the importance of work-life integration. Why is that important for personal and organizational success?
GV: In today's fast-paced business world, life is a blur between work and home. Workers might simply be stressed out with too many hours of overtime and not enough physical activity or sleep. They might be struggling to meet a project deadline or attempting to support an ailing parent. Whether they are under stress at home or at work, when they switch environments, their stress carries over. If the environment at work is not a healthy one, it wreaks havoc with their health and their ability to be a high performer. If the pressures at home are too great – and there's no support from the organization by way of an employee assistance program, for example – then performance will suffer, as well.
When an organization hires someone, they hire the whole person. Whatever challenges or problems that person faces can directly or indirectly impact the culture, teams and performance within the organization. That can require purposeful action to set boundaries.
Lifestyle management involves getting in tune with yourself and making choices. Most people will always have stressors in their lives. However, employees who master lifestyle management and put a priority on personal wellness will have a much greater resilience to respond to or reduce stress.
How does a wellness culture impact recruiting and retention?
GV: In general, the younger generation is taking more of an active interest in improving their health. They are seeking organizations that are willing to support and invest in health care. In fact, the new generation is familiar with the phrase "our health is our wealth." As a result, it's now even more of a priority for progressive organizations hiring senior-level staff to not only provide executive coaching services for leadership development, but also to provide executive coaching services in lifestyle management and wellness to attract and retain top talent.
Likewise, the organization needs to do its due diligence in the selection process to ensure that the employee not only has the knowledge and skills to excel, but also has a positive, healthy attitude and is a good fit for the organization, is supportive of wellness and will be a role model for staff.
This growing focus on health and wellness isn't exclusive to younger employees. Executives today are more health conscious and educated about health issues. They are more knowledgeable and better equipped to understand and appreciate the value of work-life integration to attain a high quality of life and sustain high levels of performance at work.
Who is responsible for organizational wellness?
GV: Sometimes corporate executives think the human resources function should be responsible and accountable for organizational wellness. HR is often involved in researching topics related to organizational wellness, especially in leading edge organizations. More importantly it is the role of HR to strategically position organizational wellness. However, it's the CEO and the entire senior management team who are responsible and accountable for organizational wellness, from buying into the concept to supporting organizational wellness, to being role models in integrating their decisions into the day-to-day business operations.
How can an organization ensure they're making strides toward better wellness?
GV: The only way to ensure progress for better wellness is to measure the impact of your corporate wellness culture. An effective corporate wellness culture is highly customized, based on what works best for each individual organization and its employees. Some examples: It can include measuring the impact of the past versus current wellness culture of your existing employees, based on data gathered in an employee survey. You can also measure the ability of your organization to attract and retain talent; measuring results of activities and participation linked to corporate wellness. The important thing is to have all the areas of corporate wellness embedded in the strategic business plan.
For the most part, making strides towards better wellness is a process of continuing to build on corporate wellness and it takes time and patience. That is, whatever aspects work extremely well for your organization, you then want to do more of. Along the way you'll also consider what adjustments have to be made to make it better.
The progress is most apparent when wellness becomes part of the strategic business plan and the personal visions of the leaders are solidly linked to an organization's vision. That's critical because if it's part of the strategic business plan, it signals a strong senior leadership commitment. What gets measured gets done! It's no longer a nebulous idea. If senior leaders are supported in achieving specific results when it comes to wellness – and an element of their compensation is tied to it – it also stands to reason that an organization is much more likely to see positive results.
Any final thoughts on the subject you'd like to share?
GV: In my experience in coaching senior executives in Fortune 1000 corporations, I've learned that we need to focus on leaders and their behaviours when it comes to creating a culture of wellness. Leaders need to make wellness a lifelong habit; organizations need to have a clear focus on wellness in their business plans, vision, values and employee-based initiatives, thereby creating a culture that values and promotes wellness. This means that leaders must actively be role models through their behaviours demonstrating that they are committed to wellness organizationally and personally. It's about actions, not words. My belief has now been supported in the Ivey Business School white paper, as well.
Leaders and employees are then better able to maximize their skills and potential and apply them on the job. Wellness also makes good business sense from an attraction and retention perspective, which adds up to dollars and cents and a greater ROI.
Imagine this: You are in great physical shape and feel good. You have a partner or spouse, family and friends who matter to you. You have time for yourself and time for them. You excel at work and you enjoy developing your successors. Your results have incredible impact on the organization. You go to work with passion and you come home with passion. You find time for your hobby, sports, fitness and other interests. You have more to give others, yet it doesn't seem like you need to expend all your energy. You have more time for community involvement and the more you give, the better you naturally feel. You are engaged and empowered, and your enthusiasm is contagious.
Now imagine you have a workforce full of leaders and employees who feel like this, thanks to a culture that supports and promotes wellness. How powerful could that be, and how limitless are the possibilities?
Gail Voisin is an executive leadership and lifestyle/wellness coach and author of All Together Now: Vision, Leadership and Wellness (Dundurn Press, 2011). She's been helping businesses across North America develop, implement and sustain thriving wellness cultures for decades.


text:
Donald Trump's call to ban Muslims from entering the country caused significant and justified outrage on both sides of the partisan divide on Monday. The swift reaction stands in stark contrast to what has happened in other countries when these sorts of comments have been made. For example in France, Marine Le Pen leads the nation's third most viable electoral party and yet has been charged with hate speech. In India, Narendra Modi has built a career on anti-Muslim rhetoric (despite trying to whitewash this over the past few years) and is now the Prime Minister with a rock star vibe like President Obama had in 2009. In Turkey, the once secular nation has now become a haven for Islamist thought, empowering Recep Tayyip Erdoğan, the President to reverse the secular principles the nation was founded on and impose a certain degree of state sponsored religious thought. He's a self-described "conservative democrat," which basically means "I believe in democracy because I win with my ultra-conservative religious views."
By stark contrast, figures like Le Pen, Modi and Erdogan do not get much traction in the United States. Donald Trump has been roundly condemned by the media and figures in his own party over the last 24 hours for his comments that the US should place a ban on Muslims entering the country. In France, the conservative media backs up Le Pen when she makes similar outlandish statements, in India much of the press has eaten out of Modi's hands and uses terrorist attacks such as the Mumbai bombings of 2008 to justify Hindu Nationalism even though it came AFTER Modi and his party, the BJP began subtle persecutions of Muslims in Western India. In Turkey, Erdoğan is opposed rhetorically by intellectuals and pro-western media figures but has allowed much of his population to become radicalized to where almost ten million Turks according to opinion polls identify with many of the tenets of radical Islam.
Speaker Paul Ryan did the right thing today as Jeb Bush did the right thing yesterday. While I oppose these conservative figures politically, they have shown the best of American tolerance and thought with the instant denunciations of Trump's damaging rhetoric. The mainstream figures of the Republican Party have impressed me in the way they stepped up on this – I believed they would follow the lead of Ted Cruz, now in many circles the presumptive GOP nominee with his nuanced support of Trump's comments. But some like Lindsay Graham did especially well, calling Trump's comments both bigotted and pivoting to how it hurts national security.
Senator Graham said:
"is putting at risk the lives of interpreters, American supporters, diplomats, and the troops in the region by making these bigoted comments."
This is the right way to frame things – without the support of populations within Muslim countries, the US is in grave danger, and the reality of the current situation is the outrageous statements of Trump and the Islam-baiting on FOX News contributes to the propaganda IS/Deash uses to recruit jihadists. At the same time, as I have previously stated I do not believe the American left fully understands the fascist and dangerous nature of radical Islam. But unlike many on the right, I do understand President Obama's hesitation to use vocabulary that will further inflame tensions – those on the right especially at FOX News who get so hung up on the President's calming rhetoric pushing him to exhibit the belligerent tone they advocate toward the region. Democrats who are more concerned about electoral success than the welfare of this nation or the women and men we send into battle (the same types of Democrats that helped give us the Iraq War) have also felt Obama has been too soft – but the President's approach contrary to the rhetoric they exhibit is appreciated overseas. This is why Jimmy Carter is seen as a far more enlightened and positive figure outside this nation than any other American postwar President. It is very possible that Obama might follow the same path in terms of reverence after he leaves office.
But despite these disagreements on tone and policy, the United States both media wise and politically showed it doesn't tolerate the type of rhetoric that so many other countries, even ones like France which the American left often cite as examples of "tolerance" seem to permit. Trump is a dangerous figure but his presence and the sharp condemnations he is receiving reinforce the faith so many of us have in America.
I am proud to be an American, despite my qualms with the right in this country. At the same time, I personally do not identify myself as an Indian-American but an American, because while I am proud of Indian culture (which includes Muslim culture) I cannot and will not idenitfy with the conservative forces culturally that have overrun that nation, making it a haven for male chauvinism and closeted racism. A figure like Trump would get elected in India, in fact one significantly worse already has.
While the Republican Party still is a bad deal for America, at least many of the leaders of that party didn't waste time in condemning something that was bad for America, even if it had political benefits to them at a time where fear, driven by media sensationalism is taking root across the country. American is great because we are good – even when I feel alone and isolated in this nation which tends to favor anti-intellectual political thought over serious policy, moments like this bring me back to that statement.


text:
Every business whether big or small should have a Facebook Fan Page. If you are new then building Facebook Fan Pages can seem daunting.
I've been testing and playing around with building some Fan Pages in different niches the last few weeks.
Here is a video on my latest success.
You need to focus on the content and providing value to your niche as well as deciding what type of page you are trying to build.
Is your page purely for entertainment or is it to provide valuable tutorial information or just pictures and videos?
You need to also do some research on the size of your market and who your core die hard fans.
My best advice is to research before setting up your page and make sure your page is not just about selling product.
If your page is a business page then make sure that it is not just about your product or service. You don't want a page that is all sell sell sell you want to tell a story or create value that will keep your fans coming back to your page.
Here is another article you may find useful if you are new to building a fan page http://www.entrepreneur.com/article/222729


text:
Misleading Blogger
Ever since I switched over to Blogger from Wordpress, I've been getting a lot more traffic here, at least in the built-in stats. With Google Analytics, I'm getting my same old low traffic in the tens, but on Blogger stats, it shows 200+ hits a day. This makes me wonder if something is wrong with either Google Analytics or Blogger stats, or if a bunch of spam bots are going to my site and Google Analytics ignores them. Whichever it is, let me know if you have experienced this, if you are a real person, that is.


text:
Advanced Uninstaller PRO
MyBestOffersToday 002.362
A way to uninstall MyBestOffersToday 002.362 from your system
This web page contains thorough information on how to remove MyBestOffersToday 002.362 for Windows. The Windows version was created by
. More information on MYBESTOFFERSTODAY can be found
. Click on
to get more facts about MyBestOffersToday 002.362 on MYBESTOFFERSTODAY's website. MyBestOffersToday 002.362 is commonly installed in the C:\Archivos de programa\mbot_es_362 folder, depending on the user's option. "C:\Archivos de programa\mbot_es_362\unins000.exe" is the full command line if you want to remove MyBestOffersToday 002.362. MyBestOffersToday 002.362's main file takes about 3.12 MB (3267248 bytes) and is named mybestofferstoday_widget.exe.
MyBestOffersToday 002.362 contains of the executables below. They take 7.96 MB (
bytes) on disk.
mbot_es_362.exe (3.80 MB)
mybestofferstoday_widget.exe (3.12 MB)
predm.exe (383.81 KB)
unins000.exe (689.51 KB)
The information on this page is only about version
of MyBestOffersToday 002.362. After the uninstall process, the application leaves some files behind on the computer. Some of these are shown below.
Directories found on disk:
C:\Program Files (x86)\mbot_es_362
C:\ProgramData\Microsoft\Windows\Start Menu\Programs\MYBESTOFFERSTODAY
The files below remain on your disk when you remove MyBestOffersToday 002.362:
C:\Program Files (x86)\mbot_es_362\mybestofferstoday_widget.exe
C:\Program Files (x86)\mbot_es_362\predm.exe
C:\Program Files (x86)\mbot_es_362\qwert10.txt
C:\Program Files (x86)\mbot_es_362\qwert13.txt
You will find in the Windows Registry that the following data will not be cleaned; remove them one by one using regedit.exe:
Additional registry values that you should clean:
HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Uninstall\mbot_es_362_is1\Inno Setup: App Path
A way to uninstall MyBestOffersToday 002.362 from your PC with Advanced Uninstaller PRO
MyBestOffersToday 002.362 is a program offered by MYBESTOFFERSTODAY. Sometimes, computer users choose to erase this program. This can be hard because doing this manually requires some skill related to PCs. One of the best QUICK way to erase MyBestOffersToday 002.362 is to use Advanced Uninstaller PRO. Take the following steps on how to do this:
1. If you don't have Advanced Uninstaller PRO on your Windows system, add it. This is a good step because Advanced Uninstaller PRO is an efficient uninstaller and general utility to clean your Windows PC.
navigate to
download the setup by clicking on the green DOWNLOAD NOW button
install Advanced Uninstaller PRO
2. Start Advanced Uninstaller PRO. It's recommended to take your time to get familiar with the program's interface and wealth of tools available. Advanced Uninstaller PRO is a very useful PC management program.
3. Press the General Tools button
4. Click on the Uninstall Programs feature
5. All the programs existing on your computer will be made available to you
6. Scroll the list of programs until you find MyBestOffersToday 002.362 or simply click the Search field and type in "MyBestOffersToday 002.362". If it exists on your system the MyBestOffersToday 002.362 app will be found automatically. After you click MyBestOffersToday 002.362 in the list , some data regarding the application is available to you:
Safety rating (in the lower left corner). This tells you the opinion other users have regarding MyBestOffersToday 002.362, ranging from "Highly recommended" to "Very dangerous".
Reviews by other users - Press the Read reviews button.
Technical information regarding the program you wish to uninstall, by clicking on the Properties button.
For instance you can see that for MyBestOffersToday 002.362:
The web site of the program is: http://es.mybestofferstoday.com
The uninstall string is: "C:\Archivos de programa\mbot_es_362\unins000.exe"
7. Press the Uninstall button. A confirmation dialog will show up. Confirm the removal by pressing Uninstall. Advanced Uninstaller PRO will uninstall MyBestOffersToday 002.362.
8. After removing MyBestOffersToday 002.362, Advanced Uninstaller PRO will ask you to run a cleanup. Press Next to perform the cleanup. All the items that belong MyBestOffersToday 002.362 which have been left behind will be detected and you will be able to delete them. By uninstalling MyBestOffersToday 002.362 with Advanced Uninstaller PRO, you can be sure that no Windows registry items, files or directories are left behind on your PC.
Your Windows computer will remain clean, speedy and able to run without errors or problems.
This page is not a piece of advice to uninstall MyBestOffersToday 002.362 by MYBESTOFFERSTODAY from your computer, nor are we saying that MyBestOffersToday 002.362 by MYBESTOFFERSTODAY is not a good application. This text only contains detailed info on how to uninstall MyBestOffersToday 002.362 supposing you want to. Here you can find registry and disk entries that other software left behind and Advanced Uninstaller PRO discovered and classified as "leftovers" on other users' computers.
2015-02-07 / Written by Daniel Statescu for
Advanced Uninstaller PRO
follow @DanielStatescu
Last update on:
2015-02-07 00:06:11.263


text:
New York, Nov 13 Actress Sonali Bendre Behl, who is being treated here for cancer, penned an emotional anniversary note for her filmmaker-husband Goldie Behl, thanking him for being her source of "strength, love and joy".On her 16th marriage anniversary, Sonali on Monday night took to Instagram to share a string of photographs of herself along with Goldie and wrote: "As soon I began to write this... I knew instantly that I would not be able to put down in words all the emotions and thoughts that were running through my head."Husband. Companion. Best friend. My rock. For me, that's Goldie Behl. Marriage is standing by each other, through thick and thin, in sickness and in health... and god knows, how we have been through that this year."
She added that "cancer is not just an individual battle… it's something that a family collectively goes through."I was also able to go on this journey, knowing that you would juggle all your responsibilities, and take on some more and hold fort back home... all this while shuttling between two continents."Sonali added: "Thank you for being my source of strength, love and joy, for being with me every single step of the way... Thank you is such an understatement for how I feel. What do I say about someone who is a part of you, who is yours and nothing and nobody else matters? Happy anniversary Goldie."The 43-year-old actress married Goldie in 2002. They have a 12-year-old son, Ranveer.She is undergoing treatment for metastatic cancer here.
Image Credit-Google


text:
Welcome Page
Cemetery Plot Map
Contact & Location
Gerald "Chub" Leonard Jansen
File: 642
Date of Birth:
Thursday, August 2, 1956
Date of Death:
Monday, April 9, 2018
Leopold, Mo
Gerald Leonard "Chub" Jansen of Leopold, Mo., passed away April 9, 2018, at his home. He was born on August 2, 1956, in Lutesville, Mo., the son of Luke Robert and Mary Louise Steinnerd Jansen. He married Leeann Renee Holzum on June 9, 1979, at St. John Catholic Church in Leopold. She survives.
He graduated from Leopold High School and later, Southeast Missouri State University with a B.S. in Industrial Technology. His many professions included carpenter, bricklayer, and 16 years as an instructor in Leopold, Perryville, and Woodland School Districts. He spent 16 years in insurance sales with the Knights of Columbus and the Missouri Farm Bureau. He was a life-time member of St. John Catholic Church at Leopold, and served on the Parish Council. He was active in the Boy Scout Troop 315, the Leopold School Board, and was a 4th Degree Knight of Columbus with Council 5898, and served as Deputy Grand Knight and selected as a Knight of the year and family of the year. Gerald enjoyed pitching horseshoes, where he was a five time State Champion with the Missouri Knights of Columbus, and was a board member of the
K of C Horseshoe Association. He was also a member of the NHPA Horseshoe Assoc. and was inducted into the Hall of Fame.He loved to fish, hunt, farm, and especially to spend time with his loving family. He served in the US Army from January 1975 until January 1978, working with electronics and telephones.
He is survived by his wife; two daughters: Hanna (Ryan) Burger and Holly (Dustin) Hoesli, all of Leopold; ten grandchildren: Haley, Reeann, and Holden Burger, and Avery, Skyler, Blaine, Talon, Aspen, Quinton, and Landric Hoesli; five brothers: Mike (Marilyn) Jansen, Larry (Sheila) Jansen, Norman (JoEllen) Jansen, Lindy (Cindy) Jansen, and Rick (Tami) Jansen; three sisters: Pam (Dennis) Horrell, Sheila Irvin, and Eva Jansen; one sister-in-law, Marilyn (the late Stan) Jansen, and his mother-in-law, Lorraine Holzum of Marble Hill. Preceding him in death were his parents, a brother, Stan, and his father-in-law, Henry Holzum. Visitation will be on Thursday, April 12, 2018, from 4:00 p.m. until 8:00 p.m. at St. John Catholic Church in Leopold, Mo. Parish prayers and a Knights of Columbus rosary will be at 7:30 p.m. A funeral mass will be celebrated on Friday, April 13, 2018, at the church at 10:00 a.m. Burial will follow in the church cemetery with military honors.


text: Concept artworks: Concept art is widely used in films, animations, video games and even in paintings. A concept artist uses several styles to achieve to final artwork. Most of the concept artworks are commissioned and you can see many of these great works in advertisements. Concept art can be digitally created using software's like Adobe Photoshop, Manga, Art rage and Corel Painter. In concept art there are various specializations like Character design,... Digital Art02 Mar 2017 Share


text:
Young Mason Follows in Family Footsteps
By Masonry
Ronald Yokimcus, Jr., of Finleyville, Penn., is our Masonry Apprentice of the Month. Yokimcus is a hard-working young mason who first learned the trade from his father and grandfather. Ron, Sr., is active in the trade, and Ron's grandfather is retired after 40 years in the trade.
"I've worked with my Dad since I was 9 years old when I started cleaning up his job sites. Dad bought me a level and taught me to lay my first brick when I was 13. I never really wanted to do anything else," Yokimcus says.
Yokimcus graduated from Ringgold High School and Mon Valley Career & Technology Center in Charleroi, Penn. He is a proud member of the Pennsylvania Bricklayers and Allied Craft Workers Union #9 and works full-time for Marsa, Inc. of Pittsburgh, Penn.
Yokimcus earned third place honors in the secondary division of the national masonry contest held last summer in Kansas City, Mo., in conjunction with the Skills USA ? VICA National Leadership and Skills Conference.
His instructor at Mon Valley, Jeff Yanits, says of Yokimcus, "Ron has excellent work habits. He maintained an 'A' average in school and was a member of the National Vocational Technical Honor Society."
About the Author
Masonry, the official publication of the Mason Contractors Association of America, covers every aspect of the mason contractor profession - equipment and techniques, building codes and standards, business planning, promoting your business, legal issues and more. Read or subscribe to Masonry magazine at www.masonrymagazine.com.


text:
Tips to Consider When Buying the Best European Cuisine
You should be healthier and strong hence you need to eat the best meals on your diet and therefore you need to check on the food that you are eating so that you can work on your eating habits. For you to keep on moving and doing the daily chores you need to eat and therefore it is important to eat the best type of meal for you to be strong and healthy. You need to choose your best taste of the European cuisine this is because there are different types of European cuisine hence you need to experience and have the taste of the best thus you will have an opportunity to explore. You need to east and experience the type of meals the people of western countries eat hence you need to have a taste of the best. You need to explore and have a memorable experience of the European cuisine hence you need to choose the best type for more exploration and a great experience. The following are factors to consider when choosing the best European cuisine meals
The first tip to consider price cost. It is essential to have a budget and this will help you to have great experience in buying the European cuisine hence you need to know the price cost of the meals. Traveling and touring to new places become more when you having a great experience while great meals hence you need to buy the meal that you can afford to as the planning of your budget.
There is the guideline of ingredient that you need to consider. You should familiarize with the eating hence you need to know the ingredient for the food preparation. You should order a variety of the best cuisine hence you need to know the ingredient hence you can have different taste s you explore more on the European cuisine of different ingredients.
Also, you need to consider the tip of a recipe. It is significant to know and inquire for the recipe and this will help to adventure by preparing your own meals hence a recipe is important for the European cuisine. A recipe will give you a hint of the European cuisine preparation hence you can decide to explore more and more on different type of the European cuisines through the recipes.
You need to consider the factor of sample checking. You need to have a sample review of the European cuisines and this will help to have the best taste of the meals. You should have great experience of European cuisine and sampling is helpful in this hence explore more.
A Beginners Guide To Restaurants


text:
Just Shred works with many Indianapolis, IN companies to ensure the proper and secured destruction of their important documents and confidential information.
You will have peace of mind knowing that your documents have been safely destroyed and there is no risk of them falling into the wrong hands! We offer drop-off or pick-up services with no long-term contract required.
Just Shred can help make your company or organization compliant with the federal governments rules and regulations and help you avoid un-necessary fines and penalties. In addition, letting your customers know you use a trusted and established company like Just Shred, Confidential Document Destruction Services, makes it easier to gain customer trust and confidence. No long term contract required. No job is too large or too small. We can accommodate a one time purge or work with you to create a customized pickup schedule that meets your needs. A Document of Destruction is provided upon request at no additional charge.
Do I need Just Shred?
We provide secured containers with built in locks for placement
at your office or warehouse.
At the federal level, FACTA (Credit Report Info), HIPAA (Healthcare) and Gramm-Leach-Bliley (Financial) require specific physical safeguards, such as shredding, to meet compliance. Essentially every organization in the United States has an obligation to protect the personal information of its clients. Just Shred can help your business meet its compliance obligations.
Why Should I Use Just Shred?
Just Shred provides outstanding customer service and provides customers with an unparalleled level of document destruction security. All organizations must comply with laws and regulations which require that it protect certain information when it is discarded. Outsourcing document destruction to Just Shred is an easy and economical way to ensure compliance with information destruction laws. We provide secure containers into which employees can securely and conveniently deposit documents to be destroyed. We then pickup the containers and destroy the contents in accordance with industry standards.
Better Shredded Than Sorry! – We Shred:
Contact Just Shred about protecting yourself, your organization and your customers with a high-security information destruction program.


text:
Considerations To Know About ielts
[forty seven][forty eight] Several international and cargo airlines fly to Cebu. Additionally, there are immediate transfer flights by using the funds's Ninoy Aquino Worldwide Airport that readily join town to other Places on this planet.
??What they posted on line regarding their price tag are correct!!! No concealed fees in contrast to marco polo. No stability deposit.??A variety of authentic looking at texts go over the array of text types present in the particular Examination. The answer important features explanations concerning why answers are accurate, and product responses for all creating tasks.|Colon Road, the oldest national street within the Philippines, is the center of a dense and compact region in downtown Cebu Town that was at the time the heart of Cebu City's shopping and small business activity, with stylish shops, dining establishments and Motion picture homes.|The link to reset your password continues to be sent. You should Examine your electronic mail. Retrieve password|TripAdvisor LLC is not really chargeable for content on exterior Websites. Taxes, fees not involved for discounts articles.|Friends can delight in a massage with the comfort in their rooms. The hotel?�s Health and fitness centre offers a sauna and steam space. The lodge delivers totally free parking.|+# test normalization/dictionary managing of halfwidth katakana: very same dictionary phrase in fullwidth and halfwidth|We weren't in a position to load the captcha take a look at required to accomplish this type. Simply click here to reload the captcha. Be sure to finish the captcha (over). E mail Despatched|Inside the early 1990s, much of the action shifted to the more modern day plus much more varied enterprise districts located in almost every one of the city regions of the city, including in what was viewed as household and leisure neighborhoods. Colon also serves as being a transit position for general public utility jeepneys (PUJ) masking arterial routes inside the town.|- "u2762u1680u002du2028u0027u01dcufe56u003au000auffe6u29fdu0020u30eeu007cU0001d178u0af1u0085",|+ "u2014u0a83ufdfcu003fu00a0u0020u000au2991U0001d179u0020u201dU000125f6u0a67u20a7ufeffu043f",|Publication sign on Subscribe now and get a 20% price reduction with your upcoming guidebook purchase. E-mail deal with|This residence has agreed to generally be A part of our Most popular Home Program, which groups alongside one another Qualities that get noticed as a consequence of their excellent services and good quality/selling price ratio with aggressive prices.|IELTS-Examination.net Apply Exams supplies intensive observe in the 4 modules at the level of the actual IELTS Examination. Giving absolutely free observe materials for all significant Examination activity sorts, this portion gives direction on how to technique Every single different activity style.}
Based on Italian historian and chronicler, Antonio Pigafetta, Magellan's entire body was in no way recovered Even with endeavours to trade for it with spice and jewels. Magellan's 2nd-in-command, Juan Sebastián Elcano took his spot as captain with the expedition and sailed their fleet back to Spain, circumnavigating the globe.
- "u002fu2563u202fu0085u17d5u200bu0020U000e0043u2014u058au3d0aufe57u2035u2028u2029",
These rules and specifications intention to keep the information on Booking.com appropriate and family-pleasant, devoid of restricting expression or powerful views. They are also applicable regardless of the remark's tone. Contributions should be travel connected.
Traveled lately? Would you like to inform us more details on the way you prepared for your vacation? Certainly, go ahead and take survey No thanks
You are able to, nevertheless, use the apply exams to comprehend the examination format and issue sorts which you might be very likely to come across.
+ "u1781u0b68u0f0cu3010u0085U00011f7au0020u0dd6u200bU000e007au000au2060u2026u002fu2026u24dcu101eu2014u2007u30a5",
We wish you to definitely share your story, with both of those the good as well as not-so-very good. All we inquire is that you comply click here with a couple of very simple tips.
??beautiful lobby with Stay band on the evening. staff members are certainly friendly and attentive. Total superior stay but possibly could pay back a lot more awareness to details within the place.??+?�ど?�せ?�本語を?�強?�る?�由?�つ?�て?�?�て?�と??��?�も?�ら?�い?�と?�ん?�。�?Whatever they posted on the internet regarding their price tag are accurate!!! No concealed charges as opposed to marco polo. No stability deposit.|Sign up for our publication and have very first decide on special discounts of twenty% or even more! Be sure to enter a valid electronic mail deal with|The viewpoints expressed in contributions are Individuals of Scheduling.com clients and Homes, rather than of Scheduling.|Though most typhoons hit just the northern Element of Cebu, the urban places in central Cebu are occasionally hit, including when Typhoon Ruping, on the read more list of worst to hit Cebu, lashed the central Cebu space in 1990.|This really is accomplished applying simple text documents identified as cookies which sit on your Personal computer. These cookies are fully Safe and sound and secure and will never have any delicate information and facts.|We'll use precisely the same rules and standards check here for all user-produced articles, and with the assets responses to that content.|English for youths and teenagers Give your click here son or daughter the most beneficial begin in life with our common programs and on line assistance for read more youths and teenagers. They are specially built to be fun, interactive and very successful.|We?�ll make an Agoda account and connection it for your Facebook account. Soon after your account is made, you'll sign in with Facebook or along with your Agoda qualifications. Electronic mail handle:|IELTS-Exam.net Practice Tests offers substantial follow while in the four modules at the level of the actual IELTS exam. Giving cost-free exercise elements for all big Test process kinds, this portion presents guidance regarding how to strategy Just about every distinctive task type.|[sixty three] It is actually now headed by the Augustinian Recollects and it has two distinctive campuses throughout the town, excluding a different campus exterior the city situated in the municipality of Balamban.}
- "ufffcu301bu0fa5U000e0103u2060u208eu17d5u034fu1009u003au180eu2009u3111",
+ //kOffsetContainsValue = 0x80000000 // Offset contains benefit for guardian node ; // The two node kinds are distinguished by the kVerticalNode flag.}
+ // Get started by producing the Distinctive empty node we use to point that the mum or dad // terminates a term. This has to be node one, because the builder assumes}


text:
Status: Closed
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
New patients welcome
Please contact us for more information!
Be the first NOLA.com user to add photos or videos of LeMaire, Mitou A Dr
Please contact us for more information!
Q-Dent Provider, New Patients Welcome, Most Insurance Accepted, Family Dentistry


text:
Dreaming in DIY (aka dreamingindiy.com) is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com.
This is the perfect book for anyone who wants to learn how to make gift baskets inexpensively that look professional. For those that want to turn their hobby into a business I tell you what you need to know and how to get started with links to business sources.
Spoil the chocolate addict in your life with this chocolate spa gift basket. It includes irresistible goodies like chocolate truffle bubble bath and chocolate truffle bath salts, and all the necessary body scrubbing products. Here is a bit of luxury, and the price is right.
A good quality satin bow can really change the look of a basket from nice to incredibly rich and sumptuous. You can buy satin type ribbon from outlet stores for about 59 cents a yard for 1 1/2 inch wide ribbon. Two yards of this would be more than enough to make inexpensive gift baskets in the largest sizes.
Looking for the perfect Get Well gift or something to make a friend smile who is going through a hard time? Who wouldn't be cheered up with this darling Gift Basket full of SUNSHINE!? Includes FREE Printable Gift Tags | Melly Moments Blog
If you're looking for the spot-on gift for a hunter, then this is it! This rustic-style gift basket features yummy goodies for hunting trips, a coffee mug, gourmet coffee and a photo frame with cool hunting paraphernalia. Perfect to remember a hunter on any occasion.
There can be five parts on how you make inexpensive gift baskets, the basket or container, the stuffing or shred (not always needed), the transparent wrap or cellophane to wrap it, the bow/ornament and card to top it all off and of course the gifts that you are making the basket with. You might already have some of the items already on hand which will bring the cost down.
For the car enthusiast you can't go wrong with this deluxe car wash bucket. It has everything they need to do a pristine job on their next wash, including the bucket to hold the sudsy water. They'll be able to wash, wax, and even treat their windshield so rain doesn't stick to it.
Help them celebrate the Christmas season in style with this classic Christmas gift basket. It has old time favorites like peanut brittle, caramel nut crunch, and peanuts done up several different ways. If they like to have company over for the holidays this has all of the crunchy and snacky things they can put out for guests.
If the container that you have chosen is very deep then you will want to put a few layers of newspaper or tissue paper on the bottom to raise all the items up so they are displayed better. Florist will often make the bottom half of a basket "fill" so that the items rise above the edge of the container and it all looks fuller and lusher than it actually is.
I ordered this Five Star Gourmet Nuts Gift Tray as a holiday gift to bring to my best friend's house for Christmas. He and his family love munching on this type of snack. The assortment arrived very quickly, was well packaged and free from damage except for one corner of the box, which was smushed in but didn't affect the interior product. The snacks came in a plastic sectioned and sealed tray for freshness which made it perfect for the special occasion. The tray features delicious, fresh and high quality whole nuts. Perfect for gift giving or to eat at home.
You can find containers and baskets everywhere from dollar stores, grocery stores, garage sales and thrift stores. If you are giving everyone the same gift basket then the dollar store would be a good place to look as they would have multiples of the same container or basket. But if you are making individual baskets then the containers that you use can come from a variety of different sources.
Most of the gifts you will find from the Popcorn Factory are under $50 – making them perfect for gifters on a budget. You can find large assortments of popcorn tins, including their signature flavors, for under $30. During the holidays, they also offer special discounts and sometimes free shipping – so you may be able to find more budget-friendly gifts during the holidays.
The truth is when you ask a diabetic what kind of gift they want for their birthday or holiday they want what everyone else wants: a flatscreen TV and a check for a million dollars! But this list is for diabetic-specific things that might help them manage their condition—all except for medical equipment. Insurance coves […]
Due to a disappointing day at the Paddocks Centre Market today, i have decided to have an auction to clear all of our Valentines Day gifts that did not sell. As well as Valentines Day gifts, the auction also includes some Christmas gifts – the prices of which are very low – with prices so low, why not bid and win yourself some chocolate! There will also be a nappy cake and a few other chocolate bouquets up for grabs.
Addresses in the following State Codes AK, HI, AE, AP, AA, PR, GU, MP, PW, AS, VI, FM and APO/FPO addresses with U.S. ZIP Codes will ship for free with value shipping. You will see this noted in checkout.
This is the ultimate gift basket for the BBQ King or Queen in your life. This gift box is chock full of everything needed for amazing barbecue fun. This box of fun includes tools, marinades, rubs, basting tools, a thermometer, a neat dish towel, and a handy box to store it all in.
We all scream for ice cream with this gift basket, since that's all they'll need to buy to complete the smorgasbord. They've even supplied the ice cream scoop so it will be easy to get the ice cream into the bowl, and even easier to cover and smother it with toppings of all sorts.
Shop the best in unique personalized baby gifts and beautiful gift baskets to celebrate one of life's most special occasions…the birth of newborn babies, toddlers and children of all ages. We specialize in one-of-a-kind keepsakes that are practical and adorable as well as affordable for new arrivals and their proud new parents as well as stunning corporate baby gifts for company and business gifting employees, clients or co-workers. Our personalized collections offer free embroidery of baby's name and or birthdate.
20. Non-Dairy Hot Chocolate Gift Basket (Frog Prince Paperie) – Dairy-free eaters will be stunned when you present them with their very own Non-Dairy Hot Chocolate Gift Basket! Mmmm… And how cute is this basket?!
If you want to give someone a bit of luxury, then this basket's one of the best gifts on the market. It's perfect for someone who enjoys different foods or someone who has some Irish ancestry for example. The basket includes Irish classics like Christmas pudding and Butlers chocolate. It would make an amazing Christmas gift for someone really special.
Buying the best gift baskets for family, friends, corporate events, clients, and employees can take a lot of thought as you carefully consider your options. Adorable Gift Baskets simplifies the process by offering you every imaginable gift basket arrangement for fast delivery to the recipient of your choice.
If you have been searching for cool baby gift ideas, you are going to love our selection. Filled with onesies, plush toys and more, our unique gift basket designs are certain to look remarkable and appreciated for their usefulness. If you are looking to decorate for a baby party, it is not uncommon to find one of our many unique creations used as a centerpiece for the gift table.
A more budget friendly garden lovers gift! A day at a garden can be exhausting and tough – make your favorite gardener happy with this gift basket that includes natural beauty products aimed at gardeners. The items include bug repellent, soap and herbal salve among others, and come packaged in a cute burlap bag. This would make a wonderful birthday gift.
If you go up to $100, you can get several bottles of wine, fine cheeses and even accompaniment baskets for wine tasting parties. Overall, the site is easy to search by price as well – and their search feature brings up plenty of selections and sizes within that price range.
To see if ShippingPass is right for you, try a 30-day free trial. Also, with ShippingPass, there is no need to worry about commitment. If you decide you want to discontinue the service, you can cancel your subscription at any time. No matter what your shipping needs, Walmart's got you covered. Sign up for ShippingPass so you can shop more, save money and live better.
If they've gone gluten free you don't have to worry about which gift to get them, you can simply get them a gluten-free gift basket and they'll be all set. This includes plenty of delicious goodies that are all GF so they can indulge without ruining their diet.
Are you looking for a unique gift idea or Awesome Chicago Gift Basket? We have unique Chicago Gift Baskets with delicious, mouth-watering treats sure to wow your friends and family? Awesome Creations has been providing unique gift baskets and gift ideas to the Chicagoland area and nationwide since 1998.
At the lower end of the budget scale, this Burt's bees essential beauty kit is the perfect choice. Burt's bees is known for high quality natural products, and this set includes 5 popular trial-size beauty products. Ideal for office secret Santa type occasions.
Perfect for the Grillmaster! Make sure to include this 8 at a time burger press and THESE Grilling Accessories and put together The Ultimate Father's Day {or ANYTIME} Grill Gift Basket | A Girl in Paradise
This is the fruit basket to end all fruit baskets, with three different fruits to enjoy. This is a great gift for someone who leads a healthy lifestyle and likes high quality fruit. Succulent pears, crisp apples, and ripe oranges make up this pack, plenty of fruit to get them through the day.
Cheese lovers will rejoice when they receive this hamper filled with an assortment of artisan cheeses. There are plenty of cheeses, and all of the accessories needed to enjoy them, like crackers, and salami, and even a cheese knife to help with the serving.
This classy Christmas gift boasts classic elegance along with, a keepsake planter and an array of some of our most delicious gourmet gifts! it's as much fun to explore and sample as it is to look at! Learn More
Your product will be shipped to its final destination to arrive in 2 business days or faster. If your order is placed before the 11 a.m. PST cutoff time, then it will ship that day and arrive 2 business days later. If your order is placed after the 11 a.m. PST cutoff time, we will do our best to process it the same day but may need an extra day.
When exam time looms, college students tend to freak out. They'll stay up through the night to cram for an exam the next day, and they'll need sustenance to see them through the wee hours of the morning. Keep them fueled with plenty of snacks, sweets, and other treats that is sure to help them ace their tests.
If you know someone who loves to read, then this is the perfect gift for them. It includes yummy snacks for reading time, gourmet coffee and a gift card for Barnes and Noble so that they can treat themselves to some more books. And it is all packaged in a fun book end chest!
Want to surprise a home chef on their birthday or at a housewarming? You can do it with this incredibly complete spice cupboard that comes in a complete box! It includes all the bare necessities and more, all in a hand crafted wooden box.
Grab some of these snuggly slippers and fill them with goodies for a pampering gift bundle anyone would love to receive! Perfect Pedicure Gift Basket Idea and PRINTABLE gift tag! | Laura's Crafty Life
Do you know someone who likes it hot? Hot, but super flavorful? Then this is the perfect gift for them. It includes 4 different award-winning Louisiana hot sauces. As a bonus, it protects you from zombies when used on a regular basis*.
Share the happiness of a new bundle of joy with a thoughtful baby gift. Our whimsical baby gift baskets are sure to bring smiles to proud parents. Congratulate the new parents with an adorable baby basket!
Transparent wrap (cellophane wrap) really gives a gift basket a great look and this is something you shouldn't scrimp on and try to do with plastic cling wrap or just a clear plastic bag. Those will make inexpensive gift baskets just look cheap, the exact thing you are trying to avoid.(Learn to make this basket HERE).
A rider would love this gift! It includes amazing goodies for both a rider, and a horse. It comes with craft soaps and other bath goodies, and horse grooming accessories. This would make for wonderful gift basket ideas for Christmas or birthday. Everything is beautifully crafted and handmade, for that extra touch of luxury.
The ShippingPass assortment is continually being optimized. Products are added and removed for lots of reasons, but the main reason is to show items that we're 100% sure we can deliver within the promised timeline.
Harry & David has over a dozen baskets under $30 and dozens more under $50. You can even find gourmet gifts with wine for less than $75. They do not offer free shipping, but when you purchase a low merchandise value gift basket, you won't spend much in shipping – in fact, it starts at $7.99 for ground.
Are you hunting down gourmet gifts on a tight budget? Then you may want to venture over to Shari's Berries – who now have combined with Cherry Moon Farms to create an awesome line of affordable Gift Baskets. They have an impressive selection of gift baskets for less than $50.
35. Super Bowl Gift Basket (Birthday Bullseye) – Make him feel like a winner with his very own Super Bowl in a basket! For even more sports-themed gifts, be sure and check out A Year of Sport-Themed Dates!
Affordable Gift Baskets
Awesome Christmas Baskets
Baby Gift Baskets
Anniversary Wine Gift Baskets
Corporate, Fathers day Gift Basket Ideas
This traditional style basket includes all the best country style gifts! Wrapped up in a rustic towel, there is a cake ornament, candles, an iron skillet and room spray among other things. This is an unbeatable housewarming gift.
This set gives them an ice cream add-in factory, and all they'll have to do is bring the ice cream to the party. There are Nerds, Snickers, M&Ms, Reese's, and plenty more than can be broken up and mixed in with the ice cream. There's also cones to make this feel like a real ice cream shop.
As in Starbucks coffee and Lindt Chocolate. Just mentioning the two brands alone makes my coffee & chocolate loving heart crave this perfect pairing. Do you ever start looking forward to your morning coffee the night before? Yeah, me too.
Shop by Type Hand-Delivered Balloons Bath / Spa Gift Baskets Breakfast Gift Baskets Chocolate Gift Baskets Cookies, Cookie Gifts / Baskets Gift Towers and Boxes Golf Gift Baskets Gourmet Gift Baskets Inspirational Gifts of Faith Italian Gift Baskets Personalized Gifts Snack Gift Baskets Sports Fan Gift Baskets Gift Baskets
It is easy to shop on a budget with Wine Country Gift Baskets and you will easily find baskets for less than $100. Shipping is free on some baskets as well and others may charge you as much as $10 for ground shipping.
Do you have a special someone who loves beer? Get them this beer guzzler's dream basket. A sleek black basket filled with all the best beer-related items: pint glasses, beer pong cups and balls, snacks… he probably already has the beer! This is a perfect combo for a housewarming, student party or birthday.


text:
Wednesday, 1 April 2015
A for Armitstead not Armistead (#AtoZChallenge)
William Armistead widower and Eleanor Halliday spinster both of this parish were married in this church by banns this 18th day of November in the year One thousand eight hundred and eleven by me John Sampson Off. Minister.
This marriage was solemnized between us signed Wm. Armitstead and the mark of Eleanor Halliday in the presence of Elizabeth Slee and James Baines.
This had been the case when he married his first wife in 1809 too.
Perhaps the minister wasn't listening to how William said his name. My phonetics teacher at high school asked me to write my name in phonetics. I duly did and was told I was wrong. I suggested to the teacher that she should listen to how I said my name and she then had to agree that I had written my name in phonetics as I said it not how she said it.
We continue to deal with this error now as no doubt other Armitsteads will confirm.
Subscribe to: Post Comments (Atom)