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Rugby Union: Youngs ready for tough challenge
Ben Youngs is expecting a difficult game when the British & Irish Lions come up against Queensland Reds at Suncorp Stadium.
The Lions have romped to big victories against the Barbarians and Western Force in the last week but can expect a much closer encounter against a strong Reds side that includes the likes of Quade Cooper, Anthony Faingaa and Ben Tapuai. The Lions are 1/16 with bet365 to beat the Reds and 11/2 to win by between 11 and 15 points. "I was delighted to get on against the Western Force, but we know the game this weekend will be the biggest challenge we have faced on tour. We have a huge amount of respect for the Reds," said Youngs. "They have a very dangerous squad. The Force really took it to us in the first 30 minutes, but then ran out of steam, perhaps because they had their minds on their game with the Waratahs on Sunday."
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Keywords: Rugby Union, Youngs, challenge
Source: Bet365
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A Life Lived in Overalls
May 15, 2018
· Memory, imprint, and a grandpa's aesthetic · My grandpa was a fashion icon. Okay, so maybe he didn't wear the most fashionable suits and no, he wasn't known outside of his close friends and family. But he was a fashion icon to our family in his own right. Papa, as we called him, had one … More A Life Lived in Overalls

subset: commoncrawl


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AEES Recruitment
Atomic Energy Education Society has expanded an advertisement of AEES Recruitment for filling up 50 TGT/PGT Teacher Posts. Job hunters who think themselves eligible for given posts they may apply by filling AEES application form on or before the end date that is given below. Apply as soon as possible.
Grab this chance, Atomic Energy Education Society invites online application form from eligible and talented candidates to fill vacant fifty job openings. End date to submit an application form is 07-April-2018. Official Site of Atomic Energy Education Society is aees.gov.in. Before applying you must check the eligibility norms.
Read: कैसे बनाये Teaching में अपना करियर
Atomic Energy Education Society Recruitment 2018 brief details:
|Organization Name
|Atomic Energy Education Society
|Post Name
|Primary Teacher, Trained Graduate Teacher, Post Graduate Teacher
|No. of Posts
|Official Site
|End date to apply
Post wise Vacancy
- Primary Teacher- 25 posts (General-13, OBC-08, SC-01,ST-03)
- TGT- 17 posts (General- 06, OBC-06, SC-02, ST-02)
- PGT- 08 posts (General-05, OBC-01, SC-01, ST-01)
- Primary Teacher – 10+2 Senior Secondary/Intermediate exam pass with 50% marks with D.El.Ed./B.El.Ed./D.Ed. and must have qualified CTET(Paper I)
- TGT– Bachelor Degree in concerned subject with 50% marks with B.Ed. and must have qualified CTET (Paper II)
- PGT– Master Degree in relevant subject with 50% marks wih B.Ed.
Mode of Selection:
Written Exam and Skill Test
Age Limit (As on 07-April-2018)
- Primary Teacher– 30 years
- TGT– 35 years
- PGT- 40 years
- General /OBC – Rs.750/-
- SC/ST/PH– No Fee
- All Category Female– No Fee
Mode of payment:
Submit the exam fee through credit card or debit card or net banking
Read: Check out All List of Teaching Jobs for All States
Pay Scale:
Selected job hunters will earn good amount of pay scale.
How to Apply for AEES Recruitment :
- Interested candidates can submit the application through the link available at the official website of AEES that is aees.gov.in
- Applicants may also apply by clicking on the Apply Online link given below.
- Fill the form with all important details and upload scanned image and signature
- After filling the form submit it within the given period of time
- At the end take print out of form
Important Dates
|Starting Date to apply
|Last Date to apply
|Fee Payment Last Date
|Exam Date
|Will be available soon
|Apply Online
|Click Here
|Candidate Login
|Click Here
|Official website
|Click Here
Read: Latest Upcoming Sarkari Naukri
Read: Last Minute Tips For प्रतियोगी परीक्षा


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Just One More Day
If I could be with you, for just one more day,
I'd tell you all the things, I have wanted to say.
I'd look into your loving eyes, and see your soul shine through,
Each day was so much happier, when I spent the day with you.
And when the day was over, I'd hold you close, and then,
I'd whisper softly in your ear,
Please wait for me, my friend
Author julia Member since Jan 11, 2011
Post Comments
shellrayb Posted on Feb 06, 2012
i like to think they will all be waiting for us one day. i know how you feel
Joanne Posted on May 21, 2011
Your poem is really beautiful and is exactly how I feel about losing my litle Roxy only a few weeks ago. The love we have for our pets is so deep and it hurts so much when they leave us.
Thanks for sharing your thoughts xx
julia Posted on May 11, 2011
Thank you both so much, for your kind words .... xx
jenking Posted on May 11, 2011
Such a beautiful dog Julia. My thoughts are with you and I do know how you feel.
katiert Posted on May 11, 2011
This is lovely Julia. I do hope they wait for us. I sooo miss my Til and I know you understand. Thankyou for posting this poem. KT xx


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Trollbeads Silver Whorl TAGBE-40017 (11452)
The spirals seen in nature, in flora and fauna, are also called whorls, and have always been a great inspiration in art. Also, fingerprints are whorls Spirals were studied by Archimedes in in connection with his attempts at squaring a circle.
Designer - Soren Nielsen
Weight - 3.02g
All Trollbeads will come perfectly packaged in either a Trollbeads pouch or box, please let us know if you need any further packaging in the notes section at checkout where our customer service team will be happy to help.
All items are sent 48 Hour by Royal Mail and delivery is completely FREE to England, Northern Ireland, Scotland and Wales. Deliveries through this channel typically take 2-5 working days to arrive, items not in stock will take a little longer and you will be notified by email. At present there is no free postage for International deliveries therefore in this case there is a minimal charge of GBP 14.99
Unwanted goods may be returned for a refund or exchange. Please use our returns form on the reverse of your invoice.
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Oh, Jodi Picoult… I don't have favorites, but you are at the top of my list when I think of amazing authors. To take a novel and make a person think so deeply about real life situations, right and wrong, ethics and values, and life or death… that's something beyond special, and it's completely enrapturing.
(Photo Credit: Google Images)
I've read most of Picoult's work, and eagerly look to the next new novel, so I bought Lone Wolf shortly after it came out, which has been a few years now. But, I never got around to reading it. I just kept it stashed in my purse, or by my bed, as the back-up book for whenever I didn't have something to read and was in need. Being in the current transition of moving out of my apartment, I've been too afraid to take a book out of the library. I don't want to lose a book in the shuffle. So it seemed like the perfect time to actually crack the spine of Lone Wolf.
Now, here's where I'm going to deviate from the system here. I'm only 50 pages in, but I'm not going to review on anything further than those 50 pages, and here's why. I am not but 50 pages in, and I'm already having some serious 'deep conversion' in my head. THAT is what impresses the hello out of me when I say that Picoult is an amazing author.
So here's the summary as of those 50 pages. We meet Luke, a man who lives, eats, and sleeps wolves. He has a teenage daughter, named Cara, who has lived with her dad and doesn't seem to mind his eccentric parenting methods. Luke's ex-wife, Georgie, has moved on to a new husband and twins, but ends up rushing back into his and Cara's life when the hospital calls about the car accident they were in. She's immediately concerned about Cara, and blaming Luke for everything, until she learns that Luke was in the accident and worse off than Cara. Because she's the ex-wife, she isn't privy to next-of-kin information, so she immediately calls her son, Edward, Clara's older brother, who moved to Thailand to get away from the family problems. It's the typical "broken family bonding due to family tragedy" scenario, but it works like a charm to lure in the reader.
Picoult uses multiple points of view separated as chapters per person to get into each character's thoughts, and this aids the reader in keeping track of them. In "Lone Wolf", I was immediately drawn into the comparisons of human vs. animal nature and nurture. As an animal person who has make it a passion to study and learn animal behavior, I find the parallels of the wolf pack behavior to human behavior fascinating. Picoult uses Luke's point of view for this, and I'm really interested to see where she takes it as I read further.
I also want to point out a piece from Edward's point of view that make my brain fire up:
"Mistakes are like the memories you hid in an attic: old love letters from relationships that tanked, photos of dead relatives, toys from a childhood you miss. Out of sight is out of mind, but somewhere deep inside you know they still exist. And you also know that you're avoiding them." (pg. 57, Picoult)
This resonated with me. I'm a perfectionist, I hate making mistakes, and as quickly as I learn from them, I stash that memory away and don't want to reflect on them once I'm past it. And of course I'm an over thinker so I went through about 10 scenarios that fit that quote. It's only just a part of Edward's stream of thought, but it made me, as the reader, think about the way my own conscious thoughts roll.
All of this, from 50 (or so) pages into this book. Now, I don't know how it's going to end, but all I'm saying is that there is always something at the end of a Picoult book that blindsides me, and I'm eager to find out what it is. And, I highly suggest you give this book a read, as well as check out some of her other works.


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Writing Short Stories
Hi everybody, I haven't been very active this year. Life has been crazy. I have a lot of things I'm trying to figure out. But, there's one thing I finally have figured out: Shorts It's about time I really start writing short stories. Why? First of all, they don't take as long to write as… Continue reading Writing Short Stories


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New stills from Drive, Harry Potter and the Deathly Hallows Part Two and posters for The Whistleblower and 5 Days of War.
Set photos of Collinwood Manor being used for Tim Burton's Dark Shadows, and extras as zombies killed on the Israeli border after they broke quarantine in the currently shooting World War Z.
"Marvel has set Don Payne, one of the credited scribes on the first "Thor", to script the sequel. Payne also penned "Fantastic Four: Rise of the Silver Surfer" and "My Super Ex-Girlfriend"…" (full details)
"Starz has partnered with Landmark Theatres for free advance screening events of the first episode of "Torchwood: Miracle Day" in about a dozen U.S. cities on July 5th and July 6th. Seating is on a first come, first serve basis in Chicago, Philadelphia, Atlanta, Denver, San Francisco, Dallas, New York City, Los Angeles, Boston, Houston, and Washington DC…" (full details)
"Francis Ford Coppola is returning to Comic-Con for the first time since 1991 and will present portions of his latest film "Twixt" on Saturday, July 23rd in Hall H…" (full details)
"The DVD and Blu-ray for "X-Men: First Class" is set to include 13 cut scenes adding up to just under 15 minutes of new footage, mostly scenes featuring CIA agent Moira Taggart (Rose Byrne) and her relationship with Charles Xavier (James McAvoy). Moira's character often disappeared for long stretches in the second half of the film, these will probably explain why…" (full details)
"Uwe Boll calls Terrence Malick's "The Tree of Life" a "piece of shit… Malick is one of the overrated directors of all time". He also slammed the Matt Damon film "The Adjustment Bureau"…" (full details)
"Film Movement has acquired North American rights to Valerie Donzelli's directorial debut "The Queen of Hearts". A fourth quarter theatrical opening in New York for the Paris-set romantic comedy will precede a limited national roll-out followed by a day-and-date cable video-on-demand premiere…" (full details)
"Strand Releasing has acquired all U.S. rights to Brazilian spiritual drama "Nosso lar" ("Our Home: The Astral City") from Buenos Aires-based FilmSharks Intl. for release later this year…" (full details)
"Chord Overstreet, who plays Sam Evans on "Glee", will not return for the third season except in possible guest starring appearances, on the flip side Darren Criss has been upgraded to a series regular…" (full details)
Tom Spilsbury, editor of Doctor Who magazine, tweets that the US and UK versions of the upcoming "Torchwood: Miracle Day" will have different edits. Certain scenes in the US version will be cut from the UK one for 'censorship', while scenes that didn't make the US cut due to timing issues will be inserted back into the UK cut.


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Wistron Corporation Becomes Newest Intellectual Ventures Customer
September 21, 2011
September 21, 2011
Today we announced our newest customer, Wistron, a Taiwanese company that is one of the world's largest original design manufacturers (ODM) in the information communications technology space. What does that mean? When you buy an electronic device like a notebook PC, mobile phone or LCD TV, there is a good chance it was manufactured by a company like Wistron and then marketed and sold under another company's brand name.
For any company with a broad global reach in the technology sector, a strong IP strategy is essential to maintaining a competitive advantage and market share. With this deal, IV provides Wistron with efficient access to IP rights and also the ability to obtain patents through our IP-for-Defense program to protect itself from potential litigation in the future.
IV's customer list continues to grow, and Wistron is the latest addition to the group of progressive companies who understand that a strong IP strategy is essential when you're competing in the technology sector.


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When comparing Inkscape vs Adobe Acrobat, the Slant community recommends Adobe Acrobat for most people. In the question"What are the best PDF editors?" Adobe Acrobat is ranked 1st while Inkscape is ranked 3rd. The most important reason people chose Adobe Acrobat is:
Since Adobe is the creator of the PDF standard, it stands to reason that Adobe's Acrobat Reader has the excellent support for it.
Ranked in these QuestionsQuestion Ranking
Pro Free and open source
Inkscape is GPL-licensed and maintains public repositories.
Pro Opens lots of file types
Inkscape supports many common formats for import (including SVG, Photoshop and Illustrator) and its plugin architecture allows more to be added.
Pro Export to different file types
You can export and save your files for example as a "normal" svg, png, jpg, bmp etc. file.
Pro Cross-platform
Pre-built binaries are available for Windows, Mac and Linux. Inkscape can be built from source on additional platforms.
Pro Integrates well into a X11-System
Its uses the X11 icon theme and desktop theme(GTK).
Pro It's really easy and fun
You can edit and create vector graphics with Inkscape.
Pro Excellent compatibility with the PDF standard
Since Adobe is the creator of the PDF standard, it stands to reason that Adobe's Acrobat Reader has the excellent support for it.
Pro Acrobat can construct a font to match scanned content
Instead of simply trying to match the font to the closest available, Acrobat can attempt to construct a font based on other characters in the document.
Pro Clean interface
Acrobat has a three tab interface. There are home, tools and document tabs.
The home tab has recently used files as well as files stored in Adobe's cloud services. It will be the first thing shown once you start the program.
The tools tab includes access to all Acrobats functionality. From here you can add tabs to panels or use the search to look for tools.
Pro Cross-platform
Available on Windows, OS X, iOS and Android.
Pro Good OCR
Acrobat can recognize characters from both both scanned documents and photos of text. Even if the photos are at an angle.
Pro Can automatically detect form fields
Acrobat has a form wizard that will attempt to overlay appropriate form fields (single-line and multi-line text fields, checkboxes, radio buttons, etc.) over existing layouts.
Pro Allows converting MS Office documents to PDFs
You can use the create PDF tool to open any Office document and convert it to an editable PDF or if you're on Windows, you can access the same functionality in Office from the Acrobat tab.
Pro Integrated cloud service
Gives access to a cloud service that allows storage and sharing of PDF files.
Pro Allows getting notified when recipients view or download a file
You can use the document cloud to get a shareable link to any of your documents. And it's possible to get notified when a document cloud document gets viewed and/or downloaded.
Pro Desktop app supports electronic signatures
You can both sign as well as send PDFs for signature.
Pro Search allows finding functionality
You don't have to look trough menus to find specific functionality, instead you can use search that's available in the sidebar and the tools tab to find the functionality you're looking for. You don't have to know the name of the tool either, related terms will work.
Pro Good annotation options
Acrobat allows commenting on text, highlighting text and leave audio messages.
Pro Video playback support
Flash and H.264 encoded video can be played back in a Adobe Reader.
Pro Allows comparing two separate PDF files for differences
Reader can compare two versions of a PDF file and highlight differences.
Pro Allows real-time collaboration
Since version 9, Reader supports real-time collaboration that synchronizes documents and includes chat.
Pro Touch-friendly interface for the desktop version
The interface has big enough button that they can be used on a tablet sized device.
Con Very slow startup on some systems
Depending on factors like how many fonts you have installed, Inkscape can take upwards of 30 seconds to launch.
Con Uses its own SVG-format by default
Inkscape might use SVG as its default format, however this SVG's contains some additional SodiPodi/Inkscape additions that can be troublesome if you want to import the SVG into some other application.
Con Based on the GTK widget toolkit
Software is based on GTK, so it might not integrate well in non-GTK environments. It also requires many dependencies on those non-GTK desktops. It also adds dependencies to GTK-environments since it is written in C++ which requires the gtkmm wrapper/interface
Con Mac version is in worse shape than Windows/Linux version
Con Incompatible with previous versions
Sometimes backward compatibility breaks. For example, pre 0.92 SVGs are incompatible with later releases (due different default resolutions).
Con Limited work with ICC CMYK color scheme
Support for ICC color profiles only in SVG files.
Con No support for large printing machine system
No support for large printing machine environment, except exporting the resulting artwork to PDF.
Con Y-axis inverted
0,0 coordinates begin in lower left corner, not upper left corner as SVG standards define.
While there's a free version of Acrobat Reader, it does not allow editing. There's a choice of Standard edition that costs $299, and Pro version for $499.


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1 butternut squash, peeled & diced
1/2 head of cauliflower, broken into florets
2 stalks of celery, diced
2 small-medium onion, diced
4 cloves garlic, in their skins
10 sage leaves, ripped
sprinkling of ground ginger
sprinkling of ground coriander
pinch sea salt
3 twists black pepper
1/4 teaspoon cayenne pepper
1/2 cup + 3/4 cup water
Prep squash, cauliflower, celery, and onions. Put them all together in a baking tray - you don't need any olive oil.
Now - the house is warm, the coat comes off and I'm toasty, too! On to the next thing...


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Before I found a legit pixel gun 3d hack online, I use to think there is no way to acquire free gems. At that time, I gave up after failing to get many amounts with cheat engines online.
I and my friends reply to threads that have anything to do with that. We told numerous players to stop wasting time on any tool out there. That is because, we haven't found out that website.
On 24th February, we embarked on another research to test top 10 websites on Google. After going through all of them, we were able to find the best that works legit. It is actually the website you see on the first paragraph of this post.
With it, I no longer have to worry about low coins or other stuffs for the game. In fact, I can play without restrictions. Weapons, characters and so many can be easily unlocked for free.
There is no more need to doubt or post discouraging replies on questions and answers sites.
I am typically a boss of my own in the game. So, you must check it if you need to get to where I am this very day.
It seems the latest release of the site that offers that is fantastic. Android users can now use the modifier to make everything in the game unlimited. They don't have to download any more patches online. From what I see so far, it is an amazing stuff anyone needs.
Its new design and responsiveness makes it better for everyone. With your mobile device, you can obtain anything easily. So, why not check it today.
After the newest update within the game, it seems the capability of getting more items has increased. You don't have to wait for 4 minutes on the website in order to get approval.
There adding system can now be done right from your internet browser. It doesn't require any special gadget in order to start. You just need your smart-phone with internet enabled to get what you want.
Even if you are new in the main game, you won't be restricted from getting started there. Meanwhile, it is important you watch this game-play to see some activities you will face while playing.
With the pixel gun 3d hack that works legit, your experience on every mission will be top notch.
No more asking for gems or free coins. You can get them all after going to the site shared on this great article.


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Best Management Practices
If you have been searching for ways to improve turf performance in marginal or poor soils, consider using compost as a soil amendment.
Dollar for dollar, fertilization does more to improve poor-quality turfgrass or to maintain good-quality turfgrass than any other management practice. Proper fertilization practices produce a dense, medium- to dark-green turf that resists pests and environmental stresses.
Liming is the practice of applying an agent to reduce soil acidity (raise pH) and make soils more favorable for turfgrass growth. Raising soil pH requires a quantity of liming material that is determined by the degree of soil acidity as well as the quality and type of liming material.
Spreaders must be properly calibrated if they are to deliver granular fertilizers and pesticides to turf at correct rates. If calibration is done incorrectly, the product may be misapplied and either too much or too little of the product will reach the turf. Spreaders and be calibrated in several ways; but the following methods are relatively simple, fast, and accurate.
A fundamental problem in turfgrass fertilization involves determining how much fertilizer is needed to supply a specified amount of nitrogen (or any other nutrient) per 1000 sq ft. Use the following examples to learn how to solve this type of problem.


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Dr. Jeannette Graf M.D. Copper Collagen Infusion and Serum Duo
- Item qualifies for VIP Easy Returns with the HSN Card. Restrictions apply. See Details
HSN Credit Card Perks & Offers Apply online or call 1-800-695-1418.
Overview & Details
You can't turn back time, but you can help your skin look more youthful and refreshed with Dr. Graf's collagen-based beauty treatments. Copper peptides and collagen work together with your skin's own collagen to help firm skin and reduce the appearance of lines and wrinkles. Isn't it time to make an investment in the future of your skin?
What You Get
Dr. Jeannette Graf M.D. Copper Collagen Infusion and Serum Duo Includes:
Good product
This product really works.i can see a difference already.the down side is if you use the firming serum as directed you are going to run out of the serum,which means you have to purchase another bottle of the serum.this can end up being costly.and you will end up with an excess of the infusion.doesnt make seance to me.sally65, WIWas this review helpful? 6 out of 6 found this review helpful
I have spent a ton on expensive collagen products and these are less expensive and work so well on my over 70 years of age skin. My skin looks much younger than my age and I plan to go auto shipment for thismooshie45, FLWas this review helpful? 2 out of 2 found this review helpful
this seems to be workig..my skin looks great for a 70year old..I plan on checking out the other products in this lineDOLLYMARIL, OKWas this review helpful? 7 out of 7 found this review helpful
Great Products
These products energize your skin and give a brighter glow and smoother skin appearance.ReRe21, MAWas this review helpful? 4 out of 4 found this review helpful
Great product
My wish would be no less than 16 0z of the serum. My skin reacts well to copper, but the copper college cream lasts past the serum. Thus I am w/o serum for several weeks while waiting to use the cream.NoNNoBistro, TNWas this review helpful? 8 out of 8 found this review helpful
Dr. Jeannette Graf, M.D.
Remind me about Dr. Jeannette Graf, M.D. upcoming shows.


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ALEXANDRIA, VA — Viewers of CBS News broadcasts and "Face The Nation" will recognize the new speaker added to the lineup at the Society of American Florists' 38th Annual Congressional Action Days, March 12-13 in Washington, D.C.
Major Garrett, the CBS News' Chief White House Correspondent and columnist at large for National Journal, will share an insider's perspective of the political scene, during the SAFPAC Reception and Dinner on March 12.
"He is a big deal," said Shawn McBurney, SAF's senior director of government relations. "Major Garrett is universally recognized as balanced, having worked for the White House teams of both CNN and Fox News. His speeches are known for his anecdotes from his time on Capitol Hill, relationships with top political players, and from the presidential campaigns he's covered."
For 30 years, Garrett has reported from the frontlines of the nation's pressing issues, chasing and breaking news stories. He began his journalism career as a police and general assignment reporter, and has since covered Congress for two major magazines and served as White House correspondent for three television networks. As the Chief White House Correspondent for CBS News, he covered the 2016 Republican race for the White House. Beginning in the summer of 2015, he covered every GOP debate and significant campaign event for CBS.
Known for asking tough questions, Major's extensive and award-winning print and television work is well-known and has drawn the public wrath of Presidents Obama and Trump among others. He has worked with outlets including U.S. News and World Report, The Washington Times, The Weekly Standard, and Mother Jones.
Garrett's presentation is among the highlights of SAF's Congressional Action Days. Last year, Congressional Action Days drew 119 growers, wholesalers, retailers and suppliers — including 35 first-time participants — from 30 states to Washington, D.C., to talk to lawmakers on Capitol Hill about their businesses and the floral industry's legislative priorities.
"The ability to sit with representatives from your state and speak with them about the important issues that impact the floral industry is so important," said Kristen Gainan-Sparboe of Gainan's Flowers in Billings, Montana, after participating last year. "Plus, it's really exciting to be on the Hill witnessing all the action and being a part of it all."
For details about this year's CAD, visit safnow.org/cad. The cut-off date for guaranteeing the SAF room rate at the CAD hotel is February 16. The early-bird registration fee is $295 for members and $395 for non-members by February 23. Your registration includes an additional FREE registration for a second person from your company who has never attended CAD before. This offer is not available online; please contact firstname.lastname@example.com.
SAF's 38th Annual Congressional Action Days is underwritten by Platinum Partner CalFlowers and Gold Partners BloomNet, FTD and Teleflora.
About SAF
The Society of American Florists is the leading organization representing all segments of the floral industry. SAF is proud to provide marketing, business and government services to its members, including growers, wholesalers, retailers, suppliers, importers, educators, designers and allied organizations. The association was chartered by an act of Congress in 1884. To learn more about SAF or to join, visitsafnow.org.
Source: The Society of American Florists


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I have a terribly tragic story to tell. Terribly tragic. Like, small children and those easily driven to tears should avert their eyes. Not that small children should be reading my blog with how often I say "fuck" but that's beside the point.
I have no internet access at home. I KNOW! How can I go on?!?! Woe! *crumples dramatically and weeps* I'm going to be without it until Monday. MONDAY! It's like the world is telling me to get outside or get a life or something. I don't like it. I'm scared. Hold me.
In all seriousness, I don't know what's wrong with our connection. I swear that we paid the bill. I have a feeling that our modem just got fried and the technician is going to have to replace it. Oh, and the window they gave us for the tech to come by is from 8 AM to 7 PM. Dude, technician guy, you suck. You need an 11 hour window? Fuckers. All of them.
To make a long, tragic story short, I've been burning up the internet here at work today to soak it in so I don't go into withdrawal or something. I don't remember the last time I was offline for over 24 hours. I might end up stark raving mad and be one of those people you hear about on TV whose neigherbors are all "She was such a nice lady. We never expected this of her." Yeah.
Anyway. I have half an hour until I'm off work so I'd better not dally too long or I'll end up with a half-written post and an angry scowl.
Onto the books!
Book #282 - The Warlord's Secret by Lizzy Ford - Not a perfect book by any means but I was captivated by it. Don't ask. I can't explain it.
Book #283 - Misfit by Jon Skovron - I liked the book, I didn't like some of the stylistic choices the suthor made. Does that make sense?
Book #284 - Soulless (The Parasol Protectorate #1) by Gail Carriger - OMG! Loved it! I was all O.O as I was reading it. And there was laughing. Out loud. While I was alone. Yay!
Book Blogger Hop & Follow Friday - I put up a picture of a man who looks like he wants to juggle two chickens. I know. I know.
In My Mailbox (07/17/11) - The Oodles of free ebooks edition - Holy pancakes! I picked up a hell of a lot of books this week. *whimpers*
On this note, I leave you until at least Monday morning. If the world ends, somebody text me since I can't get my news form twitter until then.


text:
Discovery of two new gene variants associated with reading and language abilities
Keywords: genetic inheritance, reading, language impairment
What is already known about this subject:
- Reading and language abilities are at least partly genetically inherited and probably share common genes.
- Two common childhood disorders of reading and language abilities are reading disability and specific language impairment. Both of these occur for no obvious reason (for example, in children with normal vision, hearing and intelligence, and no lack of educational opportunity).
- While some genes contributing to reading disability and specific language impairment have been identified, most of the inherited component of variation in reading and language skills is still unexplained.
What this Raine study adds:
- Genome-wide analysis of DNA data from individuals with a history of reading or language problems and their siblings who participated in the Raine Study and a number of other international studies identified two new gene variants that appear to be associated with reading and language abilities.
- Further large-scale genetic studies are needed to further understand the genetic inheritance of reading and language abilities, in people with and without reading and language disorders.
Gialluisi, A., et al. (2014). "Genome-wide screening for DNA variants associated with reading and language traits." Genes, Brain and Behavior 13(7): 686-701. [publink]
Shared genetic basis for blood pressure and depression in adolescent boys
Keywords: blood pressure, depression, children, gene
What is already known about this subject:
- A relationship exists between blood pressure and depression in children. This relationship is not explained by lifestyle factors such as diet or exercise.
- Problems with both depression and high blood pressure often emerge during adolescence and then continue throughout adulthood.
- Both depression and blood pressure are strongly genetically inherited, but it is not yet known if they share common genes.
What this Raine study adds:
- Blood pressure, measures of anxiety and depression and DNA data collected from Raine participants at 5, 8, 10, 14 years of age suggest a common underlying genetic contribution to the co-occurrence of depressive symptoms and lower blood pressure in adolescents, but only in adolescent boys.
- Two gene variants were also found to be important in controlling the rate of increase in blood pressure across childhood in boys only.
- Further study will help improve our understanding of way in which these genes contribute to blood pressure and depression and potentially contribute to new prevention or treatment strategies.
Louise, S., et al. (2014). "Monoamine oxidase a gene polymorphisms common to blood pressure and depression scores in caucasian children." Journal of Genetics Study 2(2). [publink]
Age of puberty in girls is influenced by which parent their genes come from
Keywords: reproduction, puberty, genetic inheritance, genetic imprinting
What is already known about this subject:
- There is a wide variation in the age at which puberty occurs in girls. Early puberty is associated with increased risk of diseases such as breast cancer, diabetes and heart disease.
- Lifestyle factors such as nutrition and physical activity are important in determining the age of onset of puberty, however there is increasing evidence that a complex network of genetic factors is also important.
- The activity of some genes depends on which parent they were inherited from (called 'genetic imprinting'). It is not yet clear if the parental origin of genes influences the timing of puberty.
What this Raine study adds:
- Genetic data from over 180,000 women (including Raine participants) identified 123 gene variants associated with the age of onset of puberty in girls, 29 of which were involved in the production and functioning of hormones.
- The parent from whom the genes were inherited was also important in determining the timing of puberty.
- Understanding how genetic imprinting influences puberty and physical maturation may help improve our understanding of how certain diseases are inherited.
Perry, J. R. B., et al. (2014). "Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche." Nature 514(7520): 92-7. [publink]
Identification of genes contributing to the control of blood cortisol levels
Keywords: cortisol, genome-wide association study, genetic inheritance
What is already known about this subject:
- Cortisol is an important hormone released by the body in response to stress. It has a wide range of effects that include regulation of metabolism, the cardiovascular system, brain function and responses to infection.
- Cortisol in the blood is usually found bound to a protein called corticosteroid binding globulin. Only unbound (or 'free') cortisol can be used by the body, so the amount of binding protein determines how much cortisol is available for the body to use.
- Variations in cortisol levels have been shown to contribute to an individual's risk of cardiovascular and psychiatric disease. It is not yet clear how much of this variation in cortisol levels is due to genetic inheritance.
What this Raine study adds:
- DNA data and cortisol levels from blood samples collected from over 15,000 individuals (including Raine participants) revealed that the main way in which genes influence blood cortisol levels is by controlling the capacity of corticosteroid binding globulin to bind (or hold onto) cortisol.
- Genes influenced both the reactivity and circulating concentrations of corticosteroid binding globulin, both of which contribute to its ability to bind cortisol.
- This is the first study to show a genetic basis for variation in cortisol levels between individuals. Further investigation may help in the understanding of how a person's cortisol levels may contribute to their risk of disease.
Bolton, J. L., et al. (2014). "Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin." PLoS Genetics 10(7): e1004474. [publink]
Childhood intelligence is determined by many genes
Keywords: genetic inheritance, intelligence, childhood
What is already known about this subject:
- Intelligence in childhood is strongly linked to many important life outcomes, including educational attainment, income, health and lifespan.
- It is known that intelligence is strongly genetically inherited, but the genes involved have yet to be identified.
What this Raine study adds:
- Data from intelligence tests and DNA samples from Raine participants was included in an international sample of nearly 18,000 individuals, and showed that childhood intelligence is inherited and is influenced by a large number of genes, although the specific genes could not be identified.
- Further genetic studies are required to identify the genes associated with childhood intelligence. Due to the large number of genes involved and the small size of their effects, even larger populations are needed.
Benyamin, B, Bst Pourcain, O S Davis, G Davies, N K Hansell, M-J a Brion, R M Kirkpatrick, et al. 2014. "Childhood Intelligence Is Heritable, Highly Polygenic and Associated with FNBP1L." Molecular Psychiatry 19 (2) (February): 253-8. doi:10.1038/mp.2012.184. [publink]
Identification of gene variants associated with early language development
Keywords: genetic inheritance, language development, vocabulary, infancy
What is already known about this subject:
- Learning to speak is an important stage in a child's development, and most children are able to use two-word sentences by 2 years of age.
- While it is known that a child's language abilities are partly determined by his/her genes, the genes involved have not yet been identified.
What this Raine study adds:
- Genome-wide screening using DNA samples and vocabulary scores from over 10,000 children aged 15-30 months participating in an international study (including Raine) identified a genetic region associated with language development.
- The number of words spoken in the early stages of language development was associated with genetic variation near the ROBO2 gene.
- Understanding the genetic factors involved in language development may help to identify children at risk of autism.
St Pourcain, B., Cents, R. A. M., Whitehouse, A. J. O., Haworth, C. M. A., Davis, O. S. P., O'Reilly, P. F., … Davey Smith, G. (2014). Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature Communications, 5, 4831. doi:10.1038/ncomms5831. [publink]
Anxiety and depression in preschoolers is influenced by a large number of genes
Keywords: genetic inheritance, emotional problems, psychology, preschool children
What is already known about this subject:
- Anxiety and depression can affect very young children, and emotional problems in pre-schoolers will often continue into childhood.
- A person's genes strongly affect their risk of anxiety and depression.
- Many studies have looked for genes related to anxiety and depression in adults, but very few have looked in children, even though childhood emotional problems are a risk for other childhood problems and also a range of disorders in adulthood.
What this Raine study adds:
- DNA data and behavioural assessments from children participating in the Raine study and 2 international cohort studies demonstrated that anxiety and depression in preschool children is influenced by a large number of genes, each with a small effect.
- Anxiety and depression in 3-year olds is genetically similar to anxiety and depression in adults, and genes contributing to preschool anxiety and depression also increase the risk of later psychiatric disorders.
Benke, Kelly S, Michel G Nivard, Fleur P Velders, Raymond K Walters, Irene Pappa, Paul a Scheet, Xiangjun Xiao, et al. 2014. "A Genome-Wide Association Meta-Analysis of Preschool Internalizing Problems." Journal of the American Academy of Child and Adolescent Psychiatry 53 (6) (June): 667-676.e7. doi:10.1016/j.jaac.2013.12.028. [publink]
Identification of a gene involved in the onset of puberty in boys
Keywords: genetic inheritance, puberty, sexual maturation
What is already known about this subject:
- Puberty is an important, complex stage of life, during which a series of developmental events occur, including breast and genital development, the start of menstruation and the pubertal growth spurt.
- Genetic studies examining the timing of puberty generally focus on girls, as it is easy to measure the age at which a girl has her first menstrual period.
- Little is known about the genes regulating male puberty, and it is possible that genes known to be involved in the start of menstruation in girls are also important in the initiation of puberty in boys.
What this Raine study adds:
- DNA data and assessments of pubertal development in children participating in a group of international cohorts (including Raine; 6147 girls and 3769 boys) identified the first gene for male puberty. This gene is related to the timing of sexual development and to the pubertal growth spurt.
- Genes involved in the onset of menstruation in girls and in pre-pubertal weight gain were found to be important in the timing of puberty in both boys and girls.
- Genes play an important and complex role in controlling the onset of puberty, and there is overlap in the genetic signals between the sexes.
Cousminer, D. L., Stergiakouli, E., Berry, D. J., Ang, W., Groen-Blokhuis, M. M., Körner, A., … Widén, E. (2014). Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Human Molecular Genetics, 23(16), 4452-64. doi:10.1093/hmg/ddu150. [publink]
Genetic regulation of stress hormones in adolescents
Keywords: stress hormones, birth weight, genetic inheritance, adolescent
What is already known about this subject:
- Our bodies release hormones in response to stress. Inappropriate stress responses can have negative effects on the body, and have been linked to chronic diseases including obesity, high blood pressure, depression and heart disease.
- A child's environment, both before and after birth, can change the way their body responds to stress. A low birth weight indicates that a child was exposed to a less-than-ideal environment before birth.
- The genetics of stress responses are not well understood, in particular, it is not known how genetic variation affects stress responses in adolescents, and it is not known if there is a genetic link between markers of stress at birth and stress responsiveness later in life.
What this Raine study adds:
- Analysis of DNA data and stress hormone levels at 17 years of age in Raine participants identified a gene related to stress hormone levels.
- No evidence was found for genetic control of the relationship between birth weight and stress hormone levels in adolescence.
- Identifying children who have abnormal stress responses may offer the chance of interventions designed to reduce their risk of chronic disease later in life.
Anderson, L. N., Briollais, L., Atkinson, H. C., Marsh, J. A., Xu, J., Connor, K. L., … Lye, S. J. (2014). Investigation of genetic variants, birthweight and hypothalamic-pituitary-adrenal axis function suggests a genetic variant in the SERPINA6 gene is associated with corticosteroid binding globulin in the Western Australia pregnancy cohort (Raine) study. PloS One, 9(4), e92957. doi:10.1371/journal.pone.0092957. [publink]
Identification of an otitis media susceptibility gene
Keywords: otitis media, genetic inheritance, preschool children
What is already known about this subject:
- Middle ear infection (otitis media) is common in children. Some children will have multiple cases of otitis media or have chronic otitis media that lasts for many months.
- Recurrent otitis media can cause perforation of the eardrum and hearing loss, which can then lead to problems with language development.
- Around half of a child's susceptibility to recurrent or chronic otitis media is genetic, but the genes involved have not yet been identified.
What this Raine study adds:
- DNA data from children with recurrent or chronic otitis media from the Raine cohort and the Western Australian Family Study of Otitis Media confirmed that genes within a region of chromosome 10 contribute to otitis media susceptibility.
- A gene within this chromosomal region was identified as a potential otitis media susceptibility gene.
- Further research may help to identify children at genetic risk of recurrent or chronic otitis media.
Rye, Marie S, Elizabeth S H Scaman, Ruth B Thornton, Shyan Vijayasekaran, Harvey L Coates, Richard W Francis, Craig E Pennell, Jenefer M Blackwell, and Sarra E Jamieson. 2014. "Genetic and Functional Evidence for a Locus Controlling Otitis Media at Chromosome 10q26.3." BMC Medical Genetics 15 (1) (January): 18. doi:10.1186/1471-2350-15-18. [publink]
Genes for otitis media remain unknown
Keywords: genetic inheritance, otitis media, risk factors
What is already known about this subject:
- Otitis media (inflammation of the middle ear) is common in childhood and may occur repeatedly in some children.
- Children who have repeated or chronic otitis media often receive multiple antibiotic treatments and may have grommets inserted.
- Genetics play a large part in a child's risk of otitis media, and it tends to run in families. Despite this, little is known about the genes that cause otitis media.
What this Raine study adds:
- DNA data and data from ear examinations in Raine participants and children and their families participating in a study run by the University of Minnesota showed no association between the gene variants examined and otitis media.
- Further studies are needed to identify genes that increase the risk for otitis media.
Allen, E. K., Manichaikul, A., Chen, W.-M., Rich, S. S., Daly, K. A., & Sale, M. M. (2014). Evaluation of replication of variants associated with genetic risk of otitis media. PloS One, 9(8), e104212. doi:10.1371/journal.pone.0104212. [publink]
Genes associated with adult obesity are also involved in childhood growth
Keywords: adolescent, body mass index, child, genetics, infant, obesity, risk factors
What is already known about this subject:
- Obesity is a major global public health problem. It is associated with poor mental and physical health, and many children who are obese are more likely to be obese as adults.
- An individual's susceptibility to obesity is the result of a combination of genetic, environmental and behavioural factors. Obesity develops over time, and genes related to adult obesity may begin to exert their effects during childhood or even infancy.
- Studying how genes associated with obesity in adulthood relate to changes in growth patterns across childhood may help improve our understanding of how obesity develops. However, accurate statistical models of childhood growth are required in order to get the correct information from genetic studies.
What this Raine study adds:
- Different statistical models were compared to assess how well they estimated the body mass index data (calculated from height and weight measurements) for each individual at all of the follow-ups.
- 17 genetic variants known to be associated with obesity risk in children and adults were measured from the DNA samples of the Raine participants. These genetic variants were associated with rate of growth over childhood and adolescence.
- Differences in the rate of growth for each of the genetic variants were observed between males and females.
- This study provides evidence of genetic effects that may identify individuals early in life that are more likely to rapidly increase their body mass index through childhood and be at increased risk of obesity in later life.
Warrington, Nicole M, Yan Yan Wu, Craig E Pennell, Julie a Marsh, Lawrence J Beilin, Lyle J Palmer, Stephen J Lye, and Laurent Briollais. 2013. "Modelling BMI Trajectories in Children for Genetic Association Studies." PloS One 8 (1) (January): e53897. doi:10.1371/journal.pone.0053897. [publink]
Obesity genes are also important in triggering puberty in girls
Keywords: adiposity, genetic association studies, body mass index, menarche, obesity, women's health
What is already known about this subject:
- Obesity is a global health concern, and is associated with poor health outcomes.
- Girls who are obese are more likely to start menstruating at an early age; they are also likely to be shorter and overweight or obese as adults.
- Recent studies suggest that genes involved in obesity may also be involved in the timing of puberty, but these relationships need to be confirmed in large population-based studies.
What this Raine study adds:
- Investigation of the associations between 95 obesity-related genetic variants and pubertal timing in over 90,000 girls of European descent (including Raine participants) revealed a genetic relationship between genes controlling body mass index and the timing of puberty.
- None of the genetic variants associated with central (abdominal) obesity were related to pubertal timing.
- The relationship between childhood and adolescent obesity, puberty and adult obesity is complex, and understanding the underlying genetics will help us understand their influence on adult health and disease.
Fernández-Rhodes, L., Demerath, E. W., Cousminer, D. L., Tao, R., Dreyfus, J. G., Esko, T., … Franceschini, N. (2013). Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology, 178(3), 451-60. doi:10.1093/aje/kws473. [publink]
Childhood obesity genes also influence growth during puberty
Keywords: puberty, height, growth spurt, obesity, genetics, adolescence
What is already known about this subject:
- Height growth is a complex process in which genetic inheritance plays an important part.
- A distinct growth spurt occurs during adolescence that can contribute up to 20% of an individual's final height.
- Specific growth patterns during childhood are associated with both the timing of puberty and health risks in adulthood. Obesity during childhood is linked to earlier puberty, and in turn, earlier puberty is associated with reduced adult height and an increased risk of obesity during adulthood.
- While it is estimated that genetic inheritance contributes between 60 and 90% of the variation in pubertal growth between individuals, little else is known about the genes themselves and how they influence adult stature.
What this Raine study adds:
- Genome-wide analysis in over 18,000 individuals (including data from Raine participants: height and weight at 1, 2, 3, 5, 8, 10, 14 and 17, and DNA at 14 and 17 years of age) confirmed that there is a complex genetic relationship between height growth, the timing of puberty and obesity.
- Ten gene variants were found to be associated with pubertal height growth and half of these were also associated with the timing of puberty, although not all of these genes were related to adult stature.
- All of the genes identified that were related to childhood obesity were also related to decreased overall pubertal growth.
- Understanding the effects of specific genes across multiple growth periods may help us to understand how growth patterns in childhood and adolescence affect adult health.
Cousminer, Diana L, Diane J Berry, Nicholas J Timpson, Wei Ang, Elisabeth Thiering, Enda M Byrne, H Rob Taal, et al. 2013. "Genome-Wide Association and Longitudinal Analyses Reveal Genetic Loci Linking Pubertal Height Growth, Pubertal Timing and Childhood Adiposity." Human Molecular Genetics 22 (13) (July 1): 2735-47. doi:10.1093/hmg/ddt104. [publink]
Genes common to fetal growth and adult height and metabolism
Keywords: birth weight, genetics, blood pressure, height, fetal development, diabetes
What is already known about this subject:
- Growth and development are regulated by many different genes; some genes act at specific times, while others regulate growth across different developmental stages. Research suggests that there are links between fetal growth and postnatal growth and metabolism.
- Previous genetic studies have identified genes that are associated with both birth weight and adult diseases, such as type 2 diabetes, hypertension and obesity. Further study is needed to see if there are other genes linking birth weight and adult traits, and if there are, how they work.
What this Raine study adds:
- This international study of almost 70,000 individuals discovered four new genetic variants and confirmed three previously known genetic variants as being associated with birth weight. Over 1,000 of the individuals included in this study were from the Raine Cohort, using birth size information and DNA from Raine participants and their mothers.
- As well as being associated with birth size, five of the genetic variants identified were also associated with adult traits, including type 2 diabetes, blood pressure and height.
- The remaining two genetic variants were not associated with any traits other than birth weight. These genetic variants were found to be important only during very early life, and may be associated with
non-skeletal growth.
- Genes that control fetal growth are also involved in the control of health and disease, and their effects can be seen into adulthood. These genes that link birth weight to adult outcomes may provide clues to the biological pathways involved in the process of normal growth from childhood to adulthood and also in the transition from health to disease.
Horikoshi, Momoko, Hanieh Yaghootkar, Dennis O Mook-Kanamori, Ulla Sovio, H Rob Taal, Branwen J Hennig, Jonathan P Bradfield, et al. 2013. "New Loci Associated with Birth Weight Identify Genetic Links between Intrauterine Growth and Adult Height and Metabolism." Nature Genetics 45 (1) (January): 76-82. doi:10.1038/ng.2477. [publink]
Stress responses differ in adolescent boys and girls
Keywords: adolescence, development, stress, sex characteristics, cortisol
What is already known about this subject:
- The body produces the hormone cortisol in response to stress. Cortisol levels vary between individuals and throughout the course of the day, and are influenced by genetics, developmental factors and environmental exposures.
- Healthy stress responses are an important part of normal function; however abnormal stress responses can affect physical and psychological health.
- Maturation of the stress-response system occurs around the time of puberty. Puberty also marks the onset of stress disorders in many individuals.
- Relationships between stress responses and psychological health problems have generally been studied in adults, who often have other co-existing health issues. Studying stress responses in healthy adolescents may provide more useful information about how the stress-response system matures and functions under normal conditions.
What this Raine study adds:
- Cortisol levels measured in blood and saliva samples from Raine 17-year-olds were close to reported adult levels, confirming that maturation of the stress-response system occurs during late adolescence.
- Under non-stressful conditions, girls were exposed to higher levels of cortisol, possibly due to the additional influence of sex hormones. Girls using oral contraceptives had similar cortisol levels to boys.
- Describing normal cortisol exposure and stress responses in healthy adolescents provides a useful baseline for understanding the relationship between abnormal cortisol exposure and disease vulnerability in adolescents, and also provides potential insight into the relationship between stress responses and health and disease during adulthood.
Reynolds, Rebecca M, Hilary L Hii, Craig E Pennell, Ian W McKeague, E Ron de Kloet, Stephen Lye, Fiona J Stanley, Eugen Mattes, and Jonathan K Foster. 2013. "Analysis of Baseline Hypothalamic-Pituitary-Adrenal Activity in Late Adolescence Reveals Gender Specific Sensitivity of the Stress Axis." Psychoneuroendocrinology 38 (8) (August): 1271-80. doi:10.1016/j.psyneuen.2012.11.010. [publink]
Common genetic variants do not play a role in defining the male-to-female sex ratio at birth
Keywords: genetic inheritance, gender differences, genome-wide screening
What is already known about this subject:
- Across the world, the birth rate for males is slightly higher than for females. In people of European descent is equates to an average of 106 males being born for every 100 females.
- Evidence suggests that the male to female birth ratio is at least partly due to genetic factors, although the particular genes involved have not yet been identified.
What this Raine study adds:
- Genome-wide screening of DNA samples from over 114,000 individuals (including Raine participants) did not find any detectable genetic contribution to the ratio of males to females at birth.
- The study was well powered to detect small to modestly sized genetic effects, supporting the conclusion that common genetic variants do not play a role in defining the male-to-female sex ratio at birth.
- This information will help in the design of genome-wide association studies, especially when selecting control groups for diseases specific to either males or females.
Boraska V, Jeroncic A, Colonna V, …, Zeggini E. Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet. 2012 Nov 1;21(21):4805-15. [publink]
Identification of two gene variants related to head size
Keywords: brain size, head size, genetic inheritance, genome-wide association study
What is already known about this subject:
- The size of a person's skull ('intracranial volume') determines the maximum size of their brain.
- Brain size starts to decrease after early adulthood. As the brain ages and shrinks it becomes more vulnerable to disease. Having a larger brain may help to protect against age-related degeneration.
- It is known that both head size and brain size are strongly genetically inherited, but it is not known if they are under the control of the same genes.
What this Raine study adds:
- Genome-wide screening of DNA data from over 8000 elderly participants and over 10,000 children (including Raine participants) identified two gene variants that were associated with head size (intracranial volume).
- No gene variants were identified that were related to brain size.
- Understanding the genetic contribution to head size may help to identify those most at risk of age-related degenerative brain diseases later in life.
Ikram, M. A., et al. (2012). "Common variants at 6q22 and 17q21 are associated with intracranial volume." Nature Genetics 44(5): 539-544. [publink]
Identification of genes associated with a marker of liver disease and how they change with age
Keywords: adolescent, genetics, heart disease, metabolic disease, genome-wide association study
What is already known about this subject:
- Gamma-glutamyl transferase (GGT) is an enzyme which works inside cells to protect them from damage caused by the by-products of cellular metabolism.
- GGT activity is commonly measured in blood samples as a marker of liver function. GGT activity has also been linked to diseases including type 2 diabetes, cardiovascular disease, obesity and cancer.
- GGT activity is strongly genetically determined; however, to date only a small proportion of the genes involved in GGT activity have been identified. It is not clear how GGT activity influences the risk of diseases and whether the risk changes with age.
What this Raine study adds:
- 3 new genetic variants were discovered for controlling GGT activity, and two previously described genetic variants were confirmed to be related to GGT activity. The study included DNA and blood samples from Raine participants at 14 and 17 years of age.
- Substantial overlap was found between genes affecting GGT and those affecting common metabolic and inflammatory diseases.
- Differences in GGT activity between boys and girls were present from 14 years of age, and GGT activity substantially increased between late adolescence and adulthood. One of the newly discovered genetic variants was found to be differently regulated in adults and adolescents.
- Further investigation of the genetic control of GGT in health and disease and how it changes with age may improve our understanding of a number of diseases.
Middelberg, Rita P, Beben Benyamin, Marleen H M de Moor, Nicole M Warrington, Scott Gordon, Anjali K Henders, Sarah E Medland, et al. 2012. "Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age × SNP Interaction and Cardiometabolic Disease Associations." Human Molecular Genetics 21 (2) (January 15): 446-55. doi:10.1093/hmg/ddr478. [publink]
Identification of new genes for otitis media
Keywords: otitis media, genetic inheritance, risk factors, genome-wide association study
What is already known about this subject:
- Otitis media is a common childhood disease characterised by inflammation of the middle ear, often with a build-up of fluid behind the eardrum.
- It is estimated that genetic inheritance contributes to between 40 and 70 percent of a child's risk of chronic (three months or more) or recurrent (3 or more episodes in 6 months) otitis media.
- While some studies have reported genes involved in susceptibility to otitis media, none have used a genome-wide association study to identify otitis media susceptibility genes.
What this Raine study adds:
- Genome-wide screening of DNA samples from Raine participants together with childhood otitis media data identified 3 genes as potential contributors to otitis media susceptibility.
- These associations were not reproduced when tested in a cohort with severe otitis media, possibly due to differences in otitis media severity between the two cohorts or issues with sample size.
- Further studies are warranted to fully investigate the potential role of these genes in otitis media susceptibility in children.
Rye, Marie S., Nicole M. Warrington, Elizabeth S H Scaman, Shyan Vijayasekaran, Harvey L. Coates, Denise Anderson, Craig E. Pennell, Jenefer M. Blackwell, and Sarra E. Jamieson. 2012. Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood. PLoS ONE 7 (10). doi:10.1371/journal.pone.0048215. [publink]
Identification of gene variants associated with infant head size
Keywords: genetic inheritance, infant head circumference, genome-wide association study
What is already known about this subject:
- Head circumference in infancy is used as a measure of brain size and development.
- Head size is largely genetically inherited. Gene mutations causing problems with head size have been identified, but it is not known which genes control normal variation in head size.
What this Raine study adds:
- Analysis of DNA data from over 19,000 individuals (including Raine participants) identified two gene variants associated with infant head circumference. Both of these genes are also associated with adult height, and may be related to skeletal growth.
- A third gene variant was found to be marginally associated with head circumference. This gene variant may link early brain growth with neurological disease in later life.
Taal, H Rob, Beate St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O Mook-Kanamori, Nicole M Warrington, Marika Kaakinen, et al. 2012. Common Variants at 12q15 and 12q24 Are Associated with Infant Head Circumference. Nature Genetics 44 (5): 532-538. doi:10.1038/ng.2238. [publink]
A gene related to smoking behaviour is also associated with low birth weight in babies born to mothers who smoked during pregnancy
Keywords: birth weight, genetic predisposition to disease, smoking, pregnancy
What is already known about this subject:
- Babies born to mothers who smoked during pregnancy often have a low birth weight.
- A recently identified gene variant has been shown to influence the amount a person smokes. Pregnant women with this gene variant were found to be less able to quit smoking while pregnant.
- It is not yet clear if this gene variant is also able to influence birth weight in babies born to mothers who smoked during pregnancy.
What this Raine study adds:
- Analysis of DNA samples from over 26,000 women (including mothers participating in the Raine study) found that mothers who smoked and had the gene variant under investigation had babies with lower birth weight.
- The gene variant was not associated with lower birth weight in babies born to non-smoking mothers.
- Health interventions that reduce smoking in pregnant women would help to reduce the prevalence of low birth weight.
Tyrrell, J., Huikari, V., Christie, J. T., Cavadino, A., Bakker, R., Brion, M.-J. A., … Freathy, R. M. (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight, 21(24), 5344-5358. doi:10.1093/hmg/dds372. [publink]
Fetal growth is influenced by interactions between the fetal environment and an obesity risk gene
Keywords: childhood obesity, fetal growth, genetic inheritance, maternal smoking
What is already known about this subject:
- The FTOgene has recently been identified as an important cause of obesity in both children and adults.
- It is thought that the FTO gene may begin to increase obesity risk even before birth, but its effects on fetal growth are unknown.
- Studies have not yet found an association between the FTO gene and birth weight, but this may be because its relatively small genetic effects are being masked by maternal factors that have large effects on fetal growth (such as smoking, alcohol intake, diabetes and high blood pressure).
- It is not yet known if considering the effects of genetics and environment together will reveal a role for the FTO gene on fetal growth.
What this Raine study adds:
- DNA, obstetric, fetal and postnatal growth data from Raine participants and participants in a Dutch birth cohort demonstrated that the FTO gene has opposite effects on growth before and after birth. Children with the obesity risk variant of the FTO gene had the lowest fetal growth during the third trimester of pregnancy but the highest growth during the first year of life.
- Maternal smoking significantly affected the growth patterns associated with different FTO gene variants: children born to mothers who smoked during pregnancy showed the opposite growth patterns to children born to non-smoking mothers.
- The FTO gene was confirmed as being an important determinant of childhood obesity and acts in combination with the fetal environment, particularly in relation to maternal smoking.
Marsh, J. A., Pennell, C. E., Warrington, N. M., Mook-Kanamori, D., Briollais, L., Lye, S. J., … Palmer, L. J. (2012). Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: an effect that is reversed in the offspring of smoking mothers. Journal of Developmental Origins of Health and Disease. doi:10.1017/S2040174411000638. [publink]


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'Disaster' in Vanuatu after Cyclone Pam
The first international aid arrived in Vanuatu on Sunday after Cyclone Pam tore across the Pacific archipelago, killing at least six and leaving widespread destruction.
With winds of more than 185 mph, Cyclone Pam razed homes, smashed boats and washed away roads and bridges as it struck late on Friday and into Saturday. Aid workers described the situation as catastrophic.
"The situation is a disaster," Jacqueline De Gaillande, the CEO of Vanuatu Red Cross, told NBC News. "Most people have lost their homes. All the roofs have gone. People are outside trying to find their belongings on the ground. Lots of trees have fallen on the houses. It's really a big disaster."
De Gaillande told NBC News that six deaths have been confirmed.


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Pray, Sing, Learn, Eat, and Schmooze
At B'nai Emunah we offer a number of opportunities for celebrating Shabbat.
These include:
- Friday Evening Services and Kiddush
- Saturday Morning Services and Kiddush
- Shabbat Dinners
Friday Evening Services
Friday Evening Services begin at 7:30 pm and last approximately one hour. The Shabbat service features communal singing and silent prayer, affording us a chance to leave the work-week behind.
Alternate First Friday Evening Services we will either celebrate Shabbat Shelanu or Torah Study. Torah study is always followed by mourner's kaddish for those who are in mourning and a light kiddush. Shabbat Shelanu is a Family Shabbat heavily attended by families of our B3 religious school. On those Fridays we start with a Tot Shabbat at 5:45 pm, followed by potluck at 6:15 pm, a family friendly service at 7:15 pm and dessert and coffee following the service.
On the second Friday of the month, services will be followed by a vegetarian (kosher fish OK) potluck dinner. After kiddush and hamotzi we sing several songs chosen by congregants. The meal concludes with birkat hamazon.
On the third Friday of the month the service will feature Shlomo Carlebach melodies and the oneg features wine and cheese.
Traditional service on the 4th and 5th Fridays of the month.
Shabbat Morning Services and Kiddush
Please join us every Shabbat Morning for our Traditional Service followed by a delicious kiddush and oneg. Services begin at 10:00 am and last until approximately 12:30 pm, followed by a Oneg, with food and conversation.
On the second Saturday of the month, we have our L'Dor V'Dor Shabbat service. This fun monthly program welcomes families to enjoy our Saturday Morning service with the whole community. Children can become familiar with our community's songs and prayers and join us ont he bimah for the Torah Service and dancing. A childcare professional will be onsite throughout the service to help and will lead a quiet activity in the social hall. Parents are invited to enjoy the service, but are expected to help attend to their children's needs. Snacks will be available for those that need to nosh before kiddush.
Shabbat Dinners
We are organizing monthly, potluck Shabbat dinners in members' homes. Members will be invited based on zip code to a home in their neighborhood. We are planning to invite everyone within a year.
For more information e-mail office[at]bnaiemunahsf.org or call 415-664-7373.


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Circus in the park and other artsy fun
I remember LOVING the circus. As an adult, I can't help but think of how terrible it is for the animals and so I haven't been to one in literally, decades. Well, I think my dilemma has been solved! Circus in the park is all the fun of the clowns and acrobats without the animals (except for a dog who loves it!). There are several participating parks and proceeds benefit those parks–its even for a good cause! Starting this weekend through October.
Gompers Park – 4222 W. Foster
Saturday, September 11th, 2pm & 5pm
Sunday, September 12th, 1pm & 4pm
Welles Park – 2333 W. Sunnyside
Saturday, September 18th, 2pm & 5pm
Sunday, September 19th, 1pm & 4pm
Holstein Park – 2200 N. Oakley
Saturday, September 25th, 2pm & 5pm
Sunday, September 26th, 1pm & 4pm
Portage Park – 4100 N. Long
Saturday, October 9th, 2pm & 5pm
Sunday, October 10th, 1pm & 4pm
Chase Park – 4701 N. Ashland
Saturday, October 16th, 2pm & 5pm
Sunday, October 17th, 1pm & 4pm
Have you noticed that some of the vacant storefronts in West Town and Wicker Park are all of a sudden, well, cool? Here's why! It's a project called Make Believe and it's a very creative use of vacant space to beautify and enrich the neighborhood and support our local artists.
For four months (and four months only), Chicago's Wicker Park & Bucktown neighborhoods are offering a rare glimpse into a future driven by artists.
Come sneak a peek as artists innovate the next stages of industry evolution & take on the role of improving various business sectors through creativity & innovation through the 'Make Believe' initiative.
Using the very spaces rendered vacant by the economic downturn, a carefully hand-selected crop of artistic innovators (deemed "the finalists") will temporarily display their work for the public to view. For more info and to vote for your favorites, check out http://chicagoartistsresource.org/visual-arts/node/27822 and http://makebelieve.wegotitinwpb.com/
Renegade Craft Fair this weekend!
I am still treasuring the handmade jewelry I bought at this fair last year. As I always say, you never know when you are going to find a gem at a street fair. But, Renegade is so chock full of talented artists and tradespeople, the likelihood of finding treasure is dramatically increased. Really, its free and totally worth coming to see. The weather is gorgeous and we have had a few very cool days recently to remind us that fall is right around the corner so get out one more time and enjoy!
September 11 + 12, 2010, from 11am – 7pm, all of Division Street, between Damen and Paulina
Mussel Fest in Chicago! Sept. 17th-30th
Dinotto Ristorante, 215 W.North Ave., Chicago, (312-202-0302)
Mizu Sakitori & Sushi Lounge, 315 West North Ave.,(312-951-8880)
Oceanique, 505 Main Street, Evanston, (847-864-3435)
Sweets and Savories, 1534 West Fullerton, Chicago, (312-281-6778)
Free Desserts! September 15th
I've written about the online reservation site Open Table before. It's a great one stop shop to find a cool restaurant, make reservations AND earn points towards gift certificates. That's pretty cool on it's own but now you can get a free dessert too! There are few things I like more than dessert so this is a big deal to me. 🙂
You must log on to Open Table and make a reservation at one of the participating restaurants for September 15th and that's it–the restaurant will know you are supposed to get a free dessert. Come on, what possible reason could you have for not taking advantage of that?!?!


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Every day since starting this blog, I've been watching shaving-related videos. I pay attention to as many variables as I can, especially the less obvious ones that aren't discussed in the video. I'm on a quest to identify the best practices for shaving, then incorporate them into my own shaving routine, and share them with you here.
Today I implemented two new/different variables that I'd like to share with you.
1) Hot Towel: 2 Full Minutes
I've already been using a hot towel, but I've never recorded the precise amount of time it's on my head. I casually just wait for the towel to cool off, and assumed it was 1-2 minutes. When I decided to measure exactly how long this cool-down period lasted, it was actually only 45-seconds!
I recently learned that it takes two minutes for the steam from a hot towel to soften and hydrate the wire-like hairs on our scalp. This two minutes allows the hairs to become 30% softer than normal, and thereby more comfortable to shave.
2) Shaving Cream + Shaving Soap Combo
In an effort to explain the differences between shaving cream, shaving foam, shaving gel, and shaving soap, I've been doing a deep dive into the chemical ingredients of each type of shaving product. This article will be released in early November.
While gaining a better understanding of the chemistry involved, I learned that soap and foam are more soluble, thereby making them easier to rinse from a blade. Gel and cream produce a thicker, longer lasting, and more rich lather. Preferences vary, but there are chemical differences between these lubricants that impact how they work.
Having observed a number of Italian barbers apply a small amount of shaving cream to the scalp before lathering up with traditional shaving soap, I wondered if this combination was actually useful, or merely showmanship.
So off to the shaving lab I went, carefully massaging a pea-sized drop of shaving cream into my scalp before my usual shaving soap.
Today's Shaving Lab Experiment
- Hot towel, 2 full minutes (specifically 2 hot towels at 1-min each)
- Pre-shave oil applied by hand
- Pea-size drop of shaving cream massaged into scalp
- Shaving soap applied with shaving brush
As far as the steam towel goes, the difference between 45 seconds and 2 full minutes was undeniable. The hairs were clearly more "ready" to be shaved after two minutes than they were after 45 seconds. This will now be customary for all my future shaves. If you're going to implement this, use two towels. Warm the first, and after applying it to your head, pop the second one into the microwave. By the time the first one cools off, the second one is ready to go.
As far as the shaving cream goes, I was a bit skeptical. I've never been a fan of shaving cream because it clumps up and gets clogged above the blade in my safety razor. Rinsing it with warm water doesn't do much to dislodge the buildup. So I was careful to only add a small amount, purposely not building it into a conventionally thick lather.
I have to say… Massaging that small pea-sized amount of shaving cream (I used Pacific Shaving Company) really blended well with the pre-shave oil and shaving soap, creating an exceedingly lubricated shaving surface.
While this component is non-essential to my shaving routine, I do believe it's an added benefit of comfort that I'll continue to incorporate.
Give these a try during your next shave.


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March 1, 2018
Vlog 1 Reply to Ian Craig Yi 4K+ Yi Lite external mic noise audio distortion & frame rate problems
This is a response to another YouTuber's comments, Ian Craig, about ongoing audio, microphone and video problems with the Yi 4K+ and Yi Lite Action Cameras.
Here's the original video that Ian made the comments on.
Although I do a fair bit of talking to camera in my videos, and that's an understatement 🙂 I've never really seen my videos as Vlogs, but I think this one is, so here is my first YouTube Vlog.
Please follow and like us:


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Award-winning South African novelist Imraan Coovadia tells the story of a fledgling temporal secret agent named Enver Eleven. Enver teams up with a new handler, Shanumi Six, on a vital mission to preserve humanity's legacy.
In Enver Eleven's city, fair-skinned people are a rarity and have been for centuries. They work as acrobats and jugglers or apply skin-darkening creams to conceal their condition. Johannesburg is the city that survived the end of the world thanks to the shelter provided by the thousands of miles of mining tunnels running beneath it. It's Enver's job at the Agency to make sure that the end of the world doesn't come again. He and his mentor, Shanumi Six, specialize in the hot spots of the twentieth century—Marrakech, Rio de Janeiro, Tokyo—where they travel in search of an elusive enemy, guided by the collective intelligence of the Agency's thinking machines which limit time travel to the bare minimum. When Shanumi vanishes on an assignment, Enver finds himself in the middle of a catastrophe which will require him to put his assumptions to the test in an atmosphere of conspiracy and intrigue.
Praise for the work of Imraan Coovadia
For THE WEDDING
"Both hilarious and heartbreaking, this is a story of love and loathing at first sight."
"As soon as one reads the first few pages of South African novelist Coovadia's premier novel, the cadences of Salman Rushdie and Arundhati Roy immediately come to mind."
—Library Journal
For TALES OF THE METRIC SYSTEM
"The collected stories structure recalls David Mitchell's Ghostwritten, or Jennifer Egan's A Visit From the Goon Squad. As a character says early on, 'We get most of our energy from complications.' These complications rapidly pile up, resulting in a layered, multifaceted narrative."
—Publishers Weekly
"Using the transition to the metric system as both the catalyst and symbol for radical change, Coovadia places his characters in a historical context that explains their triumphs and shortcomings without offering excuses."
—World Literature Today
"Imraan Coovadia is one of the best novelists to come out of South Africa in a long time. His prose is charming, clever and sly. A must read."
—Gary Shteyngart
Author: Imraan Coovadia
Imraan Coovadia (born 1970) has become one of the most prominent and innovative writers in South Africa. He has won the Sunday Times Fiction Prize, The University of Johannesburg Prize, the M-Net Prize and has been shortlisted for the Ama-Boeke Prize (2003) and the IMPAC Dublin International Literary Award. He is the director of the creative writing program at the University of Cape Town and is a regular contributor to various newspapers, journals and magazines such as N+1, Agni, The New York Times, Boston Globe, Times of India, and South Africa's The Mail and Guardian and Sunday Independent. His writing has been the focus of a 2016 special issue of the scholarly journal Current Writing.


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We might additionally wish to send you special provides and information simply by e-mail from other carefully selected firms we expect you may like. Your personal particulars is not going to be shared with those corporations – we send the emails and you can unsubscribe at any time. Please tick here if you are joyful to receive these messages.
Panduan lengkap untuk pengobatan rumah dan obat alami untuk penyakit umum. The Core Mother Small Group Fitness program is designed by a pre-and publish-natal health specialist for pregnant girls and new moms. This class combines purposeful and corrective movements with restorative exercises.
The focus area Cell Well being & Health in corridor A5 is the place the place producers and developers of state-of-the-art health options can present their newest offerings to the over 85,000 commerce visitors who will be making their technique to ISPO Munich from a hundred and twenty completely different countries.
The European Health and Life Expectancy Information Systems (EHLEIS) undertaking continued the work of the European Health Monitoring Expectancy Unit (EHEMU), a collaboration between the Universities of Montpellier, Leicester and the Belgian Institute of Public Well being, on figuring out whether or not the EU population resides longer and healthier lives.


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Sonasoft Corporation (OTC: SSFT) core business model includes enterprise-class email archiving, eDiscovery, and business continuity software solutions for Microsoft Business Applications on Microsoft Windows platforms, according to the company's website (see here: www.Sonasoft.com). SNNLive spoke with Andy Khanna, Founder and CEO of Sonasoft Corp. at the LD Micro "Main Event" 2015 in Bel Air, CA.
In this video interview, Mr. Khanna and our host discuss the following topics:
- Overview of Sonasoft Corporation
- Describes the compliance marketplace – the need for public companies to have fully compliant email and software solutions
- Discusses cloud technology and on developing cloud solution for its customer base
- How the company's solutions work and how companies are currently addressing technology issues in compliance
- Mr. Khanna's background
- Where and how the company's technology was developed
For more information about Sonasoft Corporation, go to: www.Sonasoft.com
The interview may contain forward looking statements about Sonasoft Corp. See Sonasoft's periodic filings with the Securities and Exchange Commission for more complete information.
© 2019 Stock News Now
Supported by Superior Web Solutions


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- Alfredo sauce
- Cooked bacon (sliced up)
- Cooked chicken (sliced up and seasoned to liking)
- Mozzarella Cheese
- Parmesan cheese
- Basil leaves
- pizza dough
If you're not using pre-made dough then make your pizza dough prior to these following instructions.
Set oven on 400 degrees F. In a sauce pan cook bacon and chicken and slice into small pieces. After both meats are cooked, pour 1/2 cup of Alfredo sauce onto the saucepan and mix. Add in a few dashes of Parmesan and basil leaves into the saucepan. Leave the saucepan on the burner for about 1-2 minutes to allow the sauce to get warm.
As the sauce is warming, spread your desired oil (olive or coconut) across the pizza dough. Next pour in the Alfredo sauce mixture onto the pizza and spread evenly. If you still have spots on the dough without sauce then you may need to add a little more. Spread sauce until the pizza dough is all covered.
Next, add mozzarella cheese onto the top of the pizza. You can add more Parmesan and basil leaves if you'd like. Finally, put the pizza into the oven for about 10 minutes. Oven time may decrease or increase depending on your desire.


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- Apple taught iPhone users not to care about specs. Now it's Google's turn.
- Apple's iPad and Watch see a huge jump in sales
- Apple to launch new educational sessions at stores, including advanced courses, performances, labs & more
- Apple selling red iPhone 7 Smart Battery Case, other accessories for Product (RED)
- Apple makes iTunes backups '1,000 times safer' with iOS 10.2
- Apple quietly releases new iBooks StoryTime app for fourth-gen Apple TV users
- Apple iPhone 7 and iPhone 7 Plus offer upgraded cameras, new A10 Fusion processor
- Apple looks set to kill off the iPhone's most annoying feature
- Apple's iOS 10 will encourage users to donate their organs
WhatsApp's new feature is brilliant news for all drunk texters
We've all, at some point in our lives, fallen foul of the phenomenon of 'WhatsApp Regret'.
Sometimes it takes the form of sending a message while drunk, then waking up the following morning and realising the error of your ways.
Occasionally it's far more instant, though, and you realise almost immediately that you Shouldn't Have Done That.
It can be a spur-of-the-moment slight, or a message whose phrasing could be interpreted the wrong way, but you can easily find yourself wishing you could delete a message before that double-tick turns blue.
If only you could somehow undo it. Well, now that you mention it…
As explained in a recent update to the WhatsApp FAQ, first spotted by TheNextWeb, you are about to get a seven-minute window to correct those mistakes. Indeed, some of you might already have it, as it seems the update has been rolled out for some (but not all) users.
You have the option of deleting messages for yourself, or for everyone in a chat. While the process will let people see you've struck your comment from the record, that will often be a much better option than them being able to see the message itself.
"Messages you successfully delete for everyone will be replaced with 'This message was deleted' in your recipients' chats," the post explains.
"Similarly, if you see 'This message was deleted' in a chat, it means that the sender deleted their message for everyone."
There is a slight caveat, though – in order for this to work, both you and the recipient need the latest version of the app.
WhatsApp is also keen to point out that you won't be notified if you've been successful in deleting the message for all recipients.
And, of course, there's every chance they will see the message before it's deleted if you're not quick enough.
If you want to delete messages for everyone, just follow these three steps (within the seven-minute window):
1. Open WhatsApp and go to the chat containing the message you wish to delete.
2. Tap and hold the message > choose Delete from the menu. Optionally, select more messages to delete multiple messages at once.
3. Tap Delete > Delete for Everyone.
If you're successful, that 'this message was deleted' text will show up for everyone else in your chat, while you'll see the words 'you deleted this message' on your end.


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Wonderful – Day 7
31st July 2015
The sun was shining outside for the first time that week, and we were struck inside shooting another scene for our new short film 'Wonderful'. Typical.
We were back at the parents house of our actress, Joanne Gallagher, completing a few scenes we had already filmed previously.
Seven year old, Chance Monahan, joined us for the beginning of the shoot, for a quick scene in the kitchen. He had to don his school uniform, which, being the summer holidays, he found highly amusing. Then after he'd been picked up by his grandma, it was on for the main bulk of the scene with our main star, David Aston, and playing his long suffering daughter, Joanne Gallagher.
For what was relatively an easy scene to shoot, we still took all day doing it. Maybe it was that hour long break for bacon and sausage sandwiches? We had to think of our priorities!
It was also the fact that we were down on crew members. It was a Friday, so people were at work, and Ben our sound guy was somewhere in Germany, so we had extra jobs to do each. Luckily we had Katy D'Arcy with us for some much needed reflector holding!
One little shot that took up much of our time was a scene in the kitchen. We have a brilliant shot from the inside of a cupboard, as David is searching for his much loved biscuits. In true indie film style, we erected a highly unsafe rig of table, chairs and newspapers, for our make-shift cupboard to stand on. Trying to get the correct camera angles proved tricky and time consuming, but ultimately worked a treat! Another scene over… next!
Posted on August 3, 2015, in Our Film News and tagged Actor, berry productions, filmmaker, filmmaking, hull, independent film, indie film, Short film, superhero, uk, wonderful. Bookmark the permalink. Leave a comment.


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Washington, DC, has a humid subtropical climate. Temperatures vary greatly in Washington, DC, throughout the year, as the city sees four distinct seasons. On average, the warmest month of the year is July, when the average high temperature is 89 degrees and the average low temperature is 71 degrees. By contrast, the coldest month is January, when the average high temperature is only 43 degrees, and the average daily low temperature reaches 29 degrees. In the spring and autumn months, temperatures are regularly in the 50s and 60s.
Washington, DC, sees the most precipitation in the month of May, when the average rainfall reaches almost 4 inches. The least amount of precipitation is in January and February, when the city only sees an average of 2.8 and 2.7 inches, respectively. Most other months see an average of between 3 and 3.5 inches of precipitation, which can include both rainfall and snowfall.
Washington, DC, sees more sunny days than cloudy ones. The average number of days per year with sun is 202, which is just under the national average of 205 days. Naturally, the most sun occurs during the summer months when there is less precipitation and longer daylight hours. June has the most hours of sunlight on average, with just over 282 hours of sunlight each year.
Washington, DC, has the highest wind speeds between December and April, when the average wind knots reaches 11. In the summer, the wind speed averages only 6 knots. The city sees an overall wind speed average of 9 knots throughout the year. The wind's direction in Washington, DC also changes based on the season. Between May and October, wind comes from the south, and the rest of the year the wind's direction is from the northwest.
The level of humidity, or water vapor in the air, is at its highest in Washington, DC during the early morning hours between August and October. During this time period, the percentage of relative humidity is nearly 90%. Generally, the humidity is always 20 to 30 percentage points higher at 7 am than it is in the afternoon at 4 pm. Humidity averages at its lowest in Washington, DC during the afternoon between February and May, when the percentage of relative humidity averages just under 50%.


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Last Updated: February 1st, 2017
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Refresh Your Soul In Psalms This Summer
Aug. 11, 2017
The Book of Psalms contains timeless songs of praise, lament, and thanksgiving that are as relevant today as they were when they were written thousands of years ago. These raw expressions of dependence on God make for excellent prayers.
Over the span of the past few months, Dr. Bryan Chapell of Unlimited Grace Ministries has been preaching his way through Psalms chapters 1 through 132 in his hit series, Summer Psalms.
Airing through August 24, Unlimited Grace listeners are learning about the eternal legacy they're leaving, what it means to be truly prosperous and blessed, how to be lifted above their trials by praising God, and how God can—and does—deliver people from the worst difficulties that life can throw their way.
These messages of from the Psalms will refresh and give hope to all with weary souls.
Encourage your listeners to visit unlimitedgrace.com to download free, study guides to accompany the daily broadcast. These helpful resources are designed to help listeners grow further in their understanding and acceptance of God's unlimited grace.
Sign up to air Dr. Bryan Chapell's fresh and engaging half-hour daily program, Unlimited Grace, by contacting the RKC Media Services Team at (818) 865-0180 or email@example.com. Click here for program samples.


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According to Indonesian authorities and environmentalists, Katsuhide Naito, believed to be a major player in the wildlife-smuggling trade, was detained at Jakarta's main airport as he was about to board a flight to Tokyo with about 250 animals hidden in his bags.
A spokesperson for the Wildlife Conservation Society said the reptiles are stuffed into four suitcases and one box, four are dead.
Before arriving in Jakarta, Naito had been in Medan, Sumatra island. He could face up to three years in prison if found guilty of breaking Indonesian wildlife laws.
He was arrested in 2005 in Australia for attempting to smuggle reptiles into the country from Indonesia.
Indonesia is home to vast rainforests and various exotic animals, but wildlife smuggling is challenging law enforcement efforts.-VNA