text:
- Review
- Open Access
Digitoxin and its analogs as novel cancer therapeutics
- Hosam A Elbaz1,
- Todd A Stueckle1, 4,
- William Tse2,
- Yon Rojanasakul1, 5Email author and
- Cerasela Zoica Dinu3, 6Email author
© Elbaz et al; licensee BioMed Central Ltd. 2012
- Received: 28 February 2012
- Accepted: 5 April 2012
- Published: 5 April 2012
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs.
- Digitoxin
- Mitotic Catastrophe
- Intracellular Sodium
- Cell Cycle Regulatory Protein
- Anticancer Mechanism
Cardiac glycosides (CGs) are a large family of chemical compounds found in several plants and animal species [1]. Plants containing CGs were used for more than 1500 years as diuretics, emetics, abortifacients, antineoplastics, and heart tonics [2]. In the 18th century, English physician and scientist William Withering discovered that a patient with congestive heart failure, "dropsy", improved after administering foxglove extract (Digitalis purpurea L.) [3]. Since then, many CGs have been isolated and their pharmacological effects have been tested; subsequently, CGs were used for treating congestive heart failure, cardiac arrhythmias, and atrial fibrillation [4, 5].
It is well established that CGs inhibit Na+/K+-ATPase and increases intracellular sodium ions [10]. The Na+/K+-ATPase is a P-type pump that actively transports potassium ions inside and sodium ions outside cells in a 2:3 stoichiometry [11]. Such activity keeps intracellular sodium levels low, thus initiating and sustaining adequate electrochemical gradient across the plasma membrane [11]. Appropriate electrochemical gradient is essential for vital cellular processes such as ion homeostasis, neuronal communication, and apoptosis [10, 12]. To maintain ion homeostasis after Na+/K+-ATPase inhibition by CGs, the cells have to restore intracellular sodium concentration to their basal levels by stimulating the Na+/Ca2+ exchange pump to extrude sodium ions out of the cell and introduce calcium ions into the cell [10]. This activity increases intracellular calcium ions and results in increased cellular phenomena such as calcium dependent signaling and myocardial contractility [5].
Cardiac glycosides and their anticancer action
Summary of most studied CGs and their anticancer activity
Structure and Natural Origin
Susceptible cancer types
IC50 Range
• Prostate cancer (PC3, DU145, and LNCaP cells)
• Leukemia (THP1, U937, and MOLT-3 cells)
0.1-10 μM
• Prostate cancer (PC3, DU145, and LNCaP cells)
0.1-10 μM
• Prostate cancer (PC3, DU145, and LNCaP cells)
• Breast cancer (MCF-7 cells)
• Renal adenocarcinoma (TK-10 cells)
• Melanoma (UACC-62 cells)
• Leukemia (K-562 cells)
• Lung (A549 cells, and NCI-H460 cells)
0.01-10 μM
• Prostate cancer (PC3, DU145, and LNCaP cells)
• Cervical cancer (Hela cells)
• Lung (A549 cells, and NCI-H460 cells)
0.1-10 μM
• Prostate cancer (PC3, DU145, LNCaP)
• Leukemia (U-937, and HL-60 cells)
• Breast cancer (MCF-7)
• Lung
• Malignant Fibroblast (VA-13)
• Liver carcinoma (HepG2 cells)
• Pancreatic cancer (PANC-1 cells)
0.1 - 1 μM
• Prostate cancer (PC3, DU145, LNCaP)
• Breast cancer (MDA-MB-435scells)
• Lung (NCI-H460 cells)
0.1-10 μM
• Breast cancer (MCF-7 cells)
• Fibroblasts
30-100 nM
Digitoxin: a well established CG
Digitoxin is one of the few CGs that have been extensively studied and have a well-established clinical profile [67, 68]. Digitoxin is a cardiotonic drug with a narrow therapeutic window; thus, toxicity is a persistent concern whenever digitoxin is considered for therapy [69]. Cardiotoxicity is frequently encountered as the most significant toxicity following digitoxin's clinical administration [70, 71]. However, digitoxin is perhaps one of the most promising anti-cancer CGs since it shows significant anticancer effect against several types of cancer including lung cancer, pancreatic cancer, leukemia, and breast cancer, all at therapeutic concentrations (see Table 1) [18, 31, 58, 68, 72]. Moreover, digitoxin has a prolonged half-life [69], which can potentially contribute to a less frequent and more stable pharmacokinetic profile in digitoxin-treated cancer patients. Such advantages qualify digitoxin for further laboratory investigations and clinical trials. However, to justify the anticancer clinical application of digitoxin, its anticancer mechanism ought to be clearly understood. Also, with the persistent concern about digitoxin's cardiotoxicity, further studies are needed to clarify the cytotoxic mechanism of digitoxin in cancer cells.
Digitoxin and its anticancer mechanism
In 2003, Xie et al. suggested that the signaling characteristics of Na+/K+-ATPase are distinct from the ion pumping activity [77]. It was shown that Na+/K+-ATPase signalosome is a multiple-protein signaling complex of 3 alpha (α) subunits and 2 beta (β) subunits that controls cellular activities like apoptosis [78], cell proliferation [79], cell motility [80], and tight junctions [81]. Subsequently, it was proposed that digitoxin at nanomolar concentrations activates Na+/K+ATPase signalosome to transmit intracellular signals. Figure 2B summarizes the intracellular effects of digitoxin upon binding to Na+/K+-ATPase at concentrations between 10-100 nM. Upon binding, digitoxin modulates the Na+/K+-ATPase protein complex activating the associated downstream signaling pathways, i.e., activation of several signaling cascades such as phospholipase C (PLC) signaling, mitogen-activated protein kinase (MAPK) signaling, phosphatidyl-inositol-3-kinase (PI3K) signaling, and Src kinase signaling.
The signaling cascades that are stimulated upon the interaction of digitoxin with Na+/K+-ATPase have mixed functions. For example, the MAPK signaling is mainly a proliferative and pro-survival signaling that can also be complemented by a pro-apoptotic signaling capability [82–88]. Src kinase signaling is a non-receptor tyrosine kinase that exhibits pro-survival as well as pro-apoptotic functions [89–97]. Therefore, digitoxin's ability to affect the downstream Na+/K+-ATPase signalosome is very complex. Such complexity, together with the digitoxin's narrow therapeutic window and its known cardiotoxicity, led to a slow progress in developing digitoxin as anticancer therapeutics [1, 2, 18, 98].
Designing digitoxin analogs as anticancer agents
The differential potency and cytotoxic selectivity of digitoxin MeON-neoglycosides and digitoxin O-glycosides have been demonstrated in various cancer cell lines. For instance, Iyer et al. compared a library of digitoxin MeON-neoglycosides and digitoxin O-glycosides in a panel of 60 different cancer cell lines [9]. They showed that O-glycosides are more potent anticancer agents when compared to MeON-neoglycosides in a variety of cancer cell lines from leukemia, to lung, pancreatic and breast cancer cells. Additionally, the authors also show that the potency of the analogs depends on their sugar moiety with the monosaccharide analog being more potent than the di- and tri-saccharide analogs, respectively. Wang et al. used artificial O-monosaccharide analogs that they tested against a panel of 60 different cancer cell lines [37–39]. They identified three digitoxin monosaccharide analogs that showed significantly greater cytotoxic potential against non-small cell lung cancer (NSCLC) cells [37–39]. The most promising of these analogs, D6-MA, was subsequently evaluated for its anticancer mechanism by Elbaz et al. [36].
Anticancer mechanism and selectivity of digitoxin and D6-MA analog
Elbaz et al. showed that the D6-MA analog was 4-5 folds more potent than digitoxin in inhibiting cell proliferation, inducing cell cycle arrest and apoptosis in NSCLC cells [36]. The authors also showed that digitoxin and D6-MA exhibited significantly greater cytotoxicity against NSCLC when compared to both primary and non-tumorigenic lung epithelial lines. The selective cytotoxicity in lung cancer cells included G2/M phase arrest and apoptosis [36]. Moreover, digitoxin and D6-MA inhibited the expression of p53, cdc2, cyclin B1, survivin, and Chk1/2, critical genes/proteins for cell proliferation.
The above suggested mechanism is supported by previous work showing that digitoxin inhibits AP-1 and NF-κB signaling through the Na+/K+-ATPase signalosome [45, 55, 106, 108–112]. AP-1 is a transcription factor that promotes the expression of cell cycle regulatory proteins such as cdc2 and cyclinB1 [113–115]. Several studies have shown that cyclinB1 is essential for cell viability [116, 117]. CyclinB1 and cdc2 are overexpressed in cancer cells [118–123] and form a complex with each other prior to mitosis. They catalyze chromatin condensation as well as nuclear envelope breakdown during mitosis [124, 125]. The cyclinB1/cdc2 complex performs a rate limiting function in G2/M phase transition and protects mitotic cells from apoptosis by activating survivin. Survivin is a vital cell cycle regulatory protein known to be overexpressed in different cancer types [126–131]. Survivin controls cell progression through mitosis by promoting the chromosomal passenger complex and regulating microtubule dynamics [132–135]. Additionally, survivin regulates the mitotic spindle checkpoint [136–139]. Several studies suggest survivin downregulation as a biomarker for mitotic catastrophe [140–142]. Also, NF-κB transcription factor regulates the expression of cell cycle regulatory proteins such as survivin [143]. Thus, by inhibiting both AP-1 and NF-κB signaling, digitoxin and D6-MA potentially inhibit the expression of cdc2, cyclin B1, survivin and Chk1/2, as shown in Figures 2 and 4. Moreover, the association of cyclin B1/cdc2 complex with survivin indicates that the complex is crucial for G2/M phase transition and cell viability, and inhibiting its expression by both digitoxin and D6-MA could potentially explain the selective cytotoxicity of these compounds towards cancer cells. Since inhibiting Chk1/2 typically elicits checkpoint abrogation and uncontrolled cell cycle progression abolished cell viability [144–146], a potential alternative mechanism of digitoxin and D6-MA's cytotoxicity may be their ability to cause checkpoint abrogation. It is unclear, however, how digitoxin and D6-MA inhibit checkpoint kinase proteins in cancer cells. Distinguishing between CG-induced cell cycle arrest and/or checkpoint abrogation will improve our understanding on how CGs including digitoxin and its analogs exert their anti-proliferative/cell death effect.
Conclusions and outlook
Digitoxin and D6-MA strongly modulate cell cycle machinery through the Na+/K+-ATPase signalosome in a manner that significantly undermines cell viability (Figure 4). However, several questions remain unanswered regarding their mechanistic control of cancer cell cycle. Delineating the mechanism of cell cycle arrest and selectivity of digitoxin and its analogs are particularly interesting. First, it will improve our understanding of how digitoxin and its analogs cause G2/M phase arrest in cancer cells. Second, it will help identify novel p53-independent therapeutic targets to mediate cancer cell death. Since many cancer types develop resistance to chemotherapy by reducing p53 expression and signaling [158-168], identifying p53-independent therapeutic targets will contribute to the development of new and more effective cancer treatments by circumventing p53 related resistance mechanisms. Third, detailing how digitoxin and D6-MA inhibit survivin expression in cancer cells will improve our understanding on how the drugs cause G2/M phase arrest and apoptosis. Last, dissecting the inhibitory effects of these compounds on survivin and p53 expression in cancer cells would explore whether and how the compounds induce mitotic catastrophe. Answering these questions will elevate our understanding on the antineoplastic mechanism of CGs at therapeutically relevant concentrations, and develop new and more effective cancer treatments [147].
Research findings and conclusions are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
This work is supported by the NIH grants R01-HL076340, GM090259, GM088839 and the NSF grant EPS-1003907.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Walking London Literally
..."was Patrick Kabanda, a Ugandan who started his training while still a chorister at St. Paul's Cathedral, Namirembe, Uganda. Mr. Kabanda taught himself to play the piano and organ and is currently completing his master's degree in organ at Juilliard in New York City. He played a stunning 'Prelude and Fugue in C minor BWV 546' by J.S. Bach, pieces by Medelssohn and Hovland and a lovely meditative piece 'Tranquility', which he wrote and premiered at this recital. If you plan on attending one of these concerts, be sure to arrive about 30 minutes early. Because we were so early, we were treated by being invited to sit in the Quire, where the archbishops sit when they gather at St. Paul's. It was very easy to drift back 400 years and imagine what London was like back then. With this perch, we were surrounded by the organ pipes and exquisite music. Admission to St. Paul's is free and they offer several services each day."

subset: commoncrawl


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LAST July Price Waterhouse, the big accounting firm, startled the profession when it announced an increase in salaries of beginning accountants to at least $29,000 from $23,000.
In higher-priced areas where the firm pays an extra cost-of-living stipend, the new salary level is now in the low $30,000's, according to Francis N. Bonsignore, national director, human resources, for the firm. At the same time Price Waterhouse has eliminated overtime pay and instituted a bonus plan for its 9,000 client-service professionals.
The salary increase was reminiscent of the announcement about 20 years ago by the law firm of Cravath, Swaine & Moore that it would increase sharply the salaries of young lawyers - a move that led to spiraling increases at other law firms.
''We have had blinders on,'' Mr. Bonsignore said last week. ''Now we want more broadly trained accountants.''
In recent years the accounting profession has faced radical changes involving the needs of clients. For example, the management consulting and taxation sections of Price Waterhouse are growing faster than the regular auditing area, which has long been the bread-and-butter part of accounting, Computerization has streamlined the industry.Continue reading the main story
''We want more liberal arts college graduates who know history and economics, who can communicate well orally and in writing, and have a good knowledge of other cultures,'' Mr. Bonsignore said.
Many clients operate as global businesses, he said, and it is logical for them to expect their accountants to think in global terms.
''We want individuals who have interpersonal and managerial skills and who can handle a broader range of clients' problems,'' he said. ''We have a top-down approach. Our view is that our accountants must look more at the business ramifications of what a client does.''
In short, he said, ''they must become business advisers.'' In recent years management consulting has become an increasingly competitive business.
The accounting profession has traditionally hired college graduates who majored in accounting. Many leading institutions like Princeton and Dartmouth, and small liberal arts colleges like Amherst and Williams, do not offer accounting majors, so fewer of their graduates have joined accounting firms.
In addition, many such graduates have chosen to start careers in management consulting or investment banking firms, lured by high salaries.
Perhaps that will change. Management consulting firms have long used the ''up or out'' philosophy, which means that those who do not become partners or vice presidents within a certain period must leave. The October stock plunge might well persuade more attractive job candidates to look at the relative security offered by accounting firms.
Price Waterhouse wants to tap this liberal arts college market. Mr. Bonsignore is an example of a broader background that the firm now wants. A graduate of Cornell University with a major in labor relations, Mr. Bonsignore earned a master's degree in public administration from Cornell's business school. He was working with Booz Allen & Hamilton Inc., the management consulting firm, when Price Waterhouse hired him to begin the new program.
It has not been easy, he acknowledged. First, the firm's 809 partners had to be convinced that paying higher salaries, which might initially cut into their profits, would be beneficial. Then he had to put the hiring program into effect.
''The real challenge has been to wear away the reliance on undergraduate-level accountants and persuade our managers to look at broader talents,'' he said.
This spring the firm expects to hire about 1,000 young accountants, or about 10 percent fewer than the 1,100 who joined the firm last year. In the group will be 800 new graduates who majored in accounting, and 200 with master's degrees in accounting or taxation.
He also hopes to hire more than 100 people with master's degrees in business administration, compared with the 80 hired last year. They will receive salaries of $50,000 or more.
In addition, the firm will hire 80 professional assistants, mostly liberal arts graduates, adding to the ranks of the 154 on hand. By 1990 he expects to be hiring 200 a year. He estimates the salary level for the assistants at about $22,000 a year, depending on the area where they work. Assigned to help the accountants, the professional assistants are encouraged to study at night so they can take the examination to become certified public accountants.
Mr. Bonsignore expects other big accounting firms to match Price Waterhouse's salary level for beginners. ''We will all benefit if they do,'' he said.
However, Jerry Walsh, a manager for the American Institute of Certified Public Accountants, said that no other major accounting firm had yet followed Price Waterhouse's example in increasing its salary scale and eliminating overtime. ''Several firms have pointed out that there is not that much difference because they pay overtime, which adds up during the tax season,'' he said.
Mr. Walsh noted that Touche Ross & Company, one of the Big Eight firms, now pays $50,000 and more to M.B.A.'s.Continue reading the main story


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Ally Tobin left New York after one too many bad dates, determined to rebuild a stable life and career as a private investigator in Silicon Valley. But when the man she knew as one name walks into her office with another, will her curiosity once again lead her to risk her heart?
The last thing Special Agent Jared Green needs is "security risk" stamped on the resume of his latest undercover identity. Especially by the woman his job forced him to leave in New York without any explanation. She may threaten his cover, but it's his heart on the line.
He's good at playing a part. She's good at catching a fake. Can they trust enough to give love another chance?
He sauntered through the door, a white, button- down shirt tucked into belted khakis. When his dark gaze found her, he stopped. Stared. Her throat dried and a rustling motion stirred in her abdomen.
"Hi. I'm Darren Ray."
Keep your cool, she commanded herself, standing and reaching across the desk. His hand was rough.
She yanked her hand back and waved at the chair. "Please, have a seat." He waited for her to sit before settling in the visitor's chair. "So, Darren, according to this, you're being considered for a programmer position in the IT department. Tell me about your background."
A professional mask settled over his features. "As you can see on my résumé, I have several years of consulting experience."
"Tell me something about your experience as a mechanic." Working on his prized old Mustang had been a favorite hobby.
The corner of his mouth twitched. "What do you mean? That's not in my résumé."
"You don't have the hands of a programmer. More of a mechanic." Oh, his hands.
"Okay, you got me." He was going to confess. This should be good. "When I'm not programming computers I'm working on my car."
"And what were you doing in New York City?"
He reached across her desk for a piece of paper, plucked a pen from its stand and scrawled something. When she took the note their fingers brushed. Meet me for dinner at Pico's at 7. I'll explain everything. Can't talk here.
The best part of working in the computer field was meeting her husband. He took up skiing and she helped him document his computer inventions! They live in "Silicon Valley" in California where their favorite thing to do is cook together for friends. Nia's specialties are dessert and veggies while her husband's are entrees and sourdough bread.
Their only pet at the moment is the sourdough starter, which lives in the fridge and requires bi-weekly feeding.
Nia blogs every day about travel, food, writing, books, skiing and photography at niasimoneauthor.com (where she won the Versatile Blogger Award and Inspiring Blogger Award).
Buy link: The Last Straw http://amzn.to/164srh
Website: niasimone.intuitwebsites.com
Facebook: facebook.com/niasimoneauthor
Twitter: @niasimone4
THE AUTHOR WILL BE GIVING AWAY: $25 Amazon gift card to one randomly drawn commenter.
Follow the tour and comment; the more you do, the better your chances of winning. The tour dates can be found here: http://goddessfishpromotions.blogspot.com/2013/08/super-book-blast-last-straw-by-nia.html


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Sponsored by the Wild Blueberry Commission of Maine
The cooking contest is a fun part of the Blueberry Festival tradition. People of all ages enter their favorite blueberry creations in the following categories: Appetizers, Breads, Rolls & Muffins, Coffee Cakes, Dessert Cakes, Cookies, Bars & Squares, Doughnuts, Desserts & Puddings, Jams & Jellies, Pancakes & Waffles, One-Crust Pies, Two-Crust Pies, Salads, Punch & Wines, Relishes, Entrees, and Sugar-Free recipes.
From Pickles to Pies and Prizes
Entries must be made from scratch. Cooks include the recipes with their entries, but do not have their names visible. Cooking contest entries are accepted on Friday at the Machias Savings Bank Community Room from 9 am – 11 am. Judging is Friday from 11-3 p.m. and winners will be announced at 6 p.m. at the Fish Fry.
Judges for the 2019 Contest: To be announced.
2019 Cooking Contest Prizes
The Wild Blueberry Commission of Maine awards prizes for the best overall entry, and for the best two-crust pie. The pie winner is also invited to participate in the pie contest at the Blue Hill Fair. Two children's awards are given for the best entries by a boy and a girl. Prizes this year are as follows: overall winner, $100; best two-crust pie winner, $100; boy and girl winners, $50.
Click here to download the Cooking Contest Entry Form.


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i got a bit of flack about my getting-ready-for-a-roadtrip post -- "overachiever mom" "what's wrong with electronics the whole way?" -- that kind of thing. and yea - it was over the top, totally worthy of some eye-rolls. truth: we didn't do most of the things i thought about; i didn't make a family favorites album, but i wish i had, we listened to enough raffi to make us (nate and i) looney. henry couldn't have cared less about the trip journal - flop. and i didn't have little packages for the kids to open every hour, but i did take a bit of time before we left to make sure I had a few tricks up my sleeve for the restless moments...
and! our time in the car was really great. we listened to charlie & the chocolate factory (on CD) and we were completely enchanted. (roald dahl is my hero). at one gas station stop we all hopped out and picked out a chocolate bar to enjoy during the next chapters. it was magical! and we chatted. and sang songs. and played the guessing game. and ate junk. and had fun.
so i'm pressing on in my idealistic ways; you can roll your eyes if you want to. this morning we made our *summer 2011 list* -- all the things we'd like to do while the fruit is ripe and the sunshine is warm and we're schedule-less.
our list is not 1/100th as cute as Meg's, (above) but it is magnet-ed to the side of the fridge and we will consult it regularly for inspiration.
here are a few things we're looking forward to:
*star gazing on mimi's lawn
*homemade ice cream, probably peach flavored
*making pajama pants & having a pajama party
(we're going to need someone with sewing skills to help with this one)
*sprinklers, splash parks, swimming
*making fruit popsicles
*sending a package to a friend
*making the kids room a more colorful, kid-happy place to be
*getting new sunglasses (mom & henry)
*eating a picnic on top of a (small :) mountain
*make-your-own pizza party
*late nights with friends
*breakfast in bed
fun starts today - we're spending the morning with our crayolas and then we're taking our creations to our dear elderly friend, ethyl.
what are you doing this summer?


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Pray the Blessing:
John 4:6-14 Jacob's well was there; so Jesus, wearied as he was from his journey, was sitting beside the well. It was about the sixth hour. A woman from Samaria came to draw water. Jesus said to her, "Give me a drink." (For his disciples had gone away into the city to buy food.)
The Samaritan woman said to him, "How is it that you, a Jew, ask for a drink from me, a woman of Samaria?" (For Jews have no dealings with Samaritans.) Jesus answered her, "If you knew the gift of God, and who it is that is saying to you, 'Give me a drink,' you would have asked him, and he would have given you living water." The woman said to him, "Sir, you have nothing to draw water with, and the well is deep.
Where do you get that living water? Are you greater than our father Jacob? He gave us the well and drank from it himself, as did his sons and his livestock." Jesus said to her, "Everyone who drinks of this water will be thirsty again, but whoever drinks of the water that I will give him will never be thirsty again. The water that I will give him will become in him a spring of water welling up to eternal life."
Declare your faith:
I believe and confess that Jesus Christ is the giver of the water of life, and that He has given us everything to live a godly life (Rev 21:6; 2 Pet 1:3).
Pray on foot:
Pray at the water source of your town or city, e.g. well, oasis, fountain, storage tank, and ask for a release of the living water in your community.


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Andrew Jackson Smith, Iowa
A. J. Smith, a leading farmer residing on section 5, Pleasant Grove Township, and a pioneer of Des Moines County, Iowa, was born in Washington County, Va., in 1817. He is a son of Daniel and Isabel (Gilson) Smith, the father a Virginian, and the mother a native of North Carolina. The paternal grandfather, Robert Smith, who was a farmer in Virginia, his native State, served in the War of the Revolution. The maternal grandfather, William Gilson, was also a farmer by occupation, and was of Irish descent. Daniel Smith was reared upon a farm in his native State, and there was united in marriage with Isabel Gilson. In the spring of 1818, they emigrated to Washington County, Ind., where Mr. Smith rented a farm until 1823, at which time they removed to Rush County, the husband there entering eighty acres of raw timber land among the settlements of the Indians. He erected a cabin, and immediately began the improvement of the tract, grubbing up the trees, and developing a farm upon which he lived for twelve years, during which time, by his thrift and enterprise, he was enabled to double his land, both in quantity and quality. Selling out, he next made his home in Hancock County, Ind., where he purchased a partially improved farm of 160 acres, and there resided until his death, which occurred Dec. 29, 1848, at the age of sixty-five years, ten months, and twelve days. Mrs. Smith survived her husband until Aug. 15, 1864, having reached her ripe old age of eighty-one years and twenty-three days at the time of her death. They were both members of the Presbyterian Church. Mr. Smith was a public-spirited man, taking an active interest in all enterprises for the good of the community. He served as Probate Judge in Rush County, Ind., for a number of years, and held the same office in Hancock County. In his political views, he was a supporter of the Whig party. Noted for his honesty and integrity, he was ever a leading man in the community where he resided, and was highly esteemed by all.
To Mr. and Mrs. Smith were born sixteen children, all of whom grew to manhood and womanhood, except one, and eleven are still living: Hiram, born Jan. 28, 1805, a retired farmer of Keokuk County, Iowa; William G., born Feb. 9, 1806, died in Indiana, Feb. 16, 1868; Robert and Jane (twins), born July 26, 1808, are both deceased; Samuel, born Nov. 26, 1809, departed this life in Rush County, Ind., Aug. 13, 1835; Mary, born Sept. 1, 1810, married Thompson Fleenor, and died in 1842; Louisa, widow of Benjamin Fry, of Hancock County, Ind.; her twin-sister Lavenia, died at birth; Elizabeth, born April 15, 1814, wedded Thomas McKinnon, of Henry County, Iowa; our subject is next in order of birth; Nancy Ellen, born Sept. 24, 1819, became the wife of Solomon Tiner, of Missouri; Sarah Ann, born July 27, 1821, widow of A. J. Porter, of Dallas, Tex.; Diroxia L., born Dec. 5, 1826, married Samuel Tibbits, a resident farmer of Pleasant Grove Township, died Feb. 22, 1888; Lillas, born Dec. 24, 1828, wife of David Davis, of Keokuk County, Iowa; Jeroial D., born Jan. 14, 1829, now residing in Texas; John H., born July 16, 1832, whose home is in Keokuk County, Iowa.
At the age of twenty-five years, our subject left the parental roof and emigrated to Iowa, settling in Pleasant Grove Township, Des Moines County. In the spring of 1843, he purchased 120 acres of partially improved land on section 10, immediately began the work of development, and upon that farm twelve years were passed. Then purchasing a farm on section 11 of the same township, he made it his home for the succeeding ten years, when he removed to Washington Township. After residing upon the last-purchased farm for three years, he again removed to Pleasant Grove Township, residing for twenty years on section 15, and then moved to section 5, which still continues to be his home. After having given his children farms, Mr. Smith is yet the owner of 1,518 acres of land, all of which were gained through his own efforts. His father being a poor man, he received no financial aid, but began his financial career by working for twenty-five cents a day. At the time of his emigration to Iowa, he had but $64 in money, and two ox teams, with which he commenced breaking prairie. The perseverance and energy which have made his life a success, may well serve as an example to future generations.
On the 18th of April, 1847, the marriage of Mr. Smith and Jane Westfall, a native of New York, born June 20, 1829, was celebrated. This worthy couple are the parents of twelve children, all of whom are living: Francis M., born March 20, 1848, a resident of Pleasant Grove Township; Frederick N., born Aug. 28, 1850, whose hone is in Washington Township; Isabella, born Aug. 30, 1852, is the wife of David L. Davis, of Keokuk County, Iowa; Asbury D., born May 17, 1854, is engaged in farming in Ness County, Kan.; A. J., born June 1, 1856; Mary J., born March 26, 1858, is the wife of Ira Reedfern, a farmer of Pleasant Grove Township; R. A., born April 8, 1860, whose home is in Wapello County, Iowa.; A. E., born Feb. 18, 1862, of Pleasant Grove Township; John H., born Oct. 30, 1864, residing in Jefferson County, Iowa; Minnie, born Nov. 12, 1865, wedded George Overman, of Des Moines County; Squire, born Nov. 18, 1867, now of Pleasant Grove Township; Ira, born Feb. 23, 1870, is still at home.
Mr. Smith has held various township offices, was Trustee for several terms, and County Supervisor for one term. His occupation has always been that of a farmer, though he also engages in raising and shipping stock. In the support of charitable, educational and religious institutions, he is very liberal, and in him the temperance cause finds an earnest advocate. To such men as Mr. Smith, Des Moines County owes her present prosperous condition, and as a pioneer, citizen and friend he receives the highest respect and esteem from all with whom he comes in contact. He can now look back over a well-spent life, and also takes pleasure in his children, who are honorable men and women in their several communities. The portraits of Mr. and Mrs. Smith appear upon the preceding page.
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Saturday, December 31, 2016
Lightmen !!
11 comments:
- AnonymousJanuary 1, 2017 at 10:59 PM
cool bonanza!!!ReplyDelete
You're absolutely correct. Everything by The Lightmen is fantastic! Thanks!ReplyDelete
You both are very welcome! Enjoy the tunesReplyDelete
Thanks so much for this! Only thing missing is Space City!ReplyDelete
And guess what ...I scored a copy of that for $1. In fact I added that release on DiscogsDelete
Cool. Would you be willing to share it?Delete
Hello Ethics, Just wondering again whether you might consider sharing Space City?Delete
Thanks again,
Currently, i don,t have proper equipment for ripping. I wish I could, though.Delete
A side note: I actually befriended Bubbha Thomas and his son, on Facebook. He says that all of the early Lightmen releases will be reissued this summer. I've seen nothing of this coming to fruition.
Perhaps a cassette? I'd be happy to do the ripping.Delete
Any chance you could re-share these? Link doesn't appear to work any more.Delete


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Diggin': Dom Flemons – Big Head Joe's March
inDiggin'on April 16, 2015
If you haven't heard already Dom Flemons is releasing What Got Over, an EP of extra cuts from his 2014 release Prospect Hill for Record Store Day. Big Head Joe's March is the first track from this exclusive album and does NOT disappoint. Dom explores some of the deeper roots of American music by pairing independently played bass and snare drums with quills and an intoxicating banjo riff played on none other than his freakishly large banjo, Big Head Joe.


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Toyota idles plants for extra 11 days
Automaker extends shutdown of Japanese plants beyond previously announced three-day hiatus.
TOKYO, Japan (CNN) -- Toyota announced Tuesday it will idle all 12 of its wholly owned factories in Japan for an extra 11 days in response to the slumping auto market.
The company already had announced a three-day shutdown, which was set to begin in January. Company spokesman Paul Nolasco said the longer stretch, scheduled for February and March, will help the company get through the downturn without cutting jobs.
"In good times and bad, we try to keep output in line with demand, keeping production in line with demand," Nolasco said. "This will help even out production flow."
Three of the factories to be shuttered are auto assembly plants, while the rest make parts. Expanding that shutdown is a rare move that is likely to produce a ripple effect among its suppliers of parts and raw materials.
The announcement followed dismal numbers posted Monday by the Big Three U.S. manufacturers. Chrysler saw December sales decline 53% from last year, while General Motors (GM, Fortune 500) saw its receipts drop 31% and Ford (F, Fortune 500) dropped 32% .
In December, Toyota (TM) warned that that it would report its first loss as a public company. Toyota, Honda and Nissan all reported an annual drop in U.S. sales, the first time there's been such a broad-based decline for those powerful Asian brands.
A week earlier, Honda (HMC) slashed its earnings forecast for 2009 and said it saw "no prospect for recovery" in the midst of a widespread downturn.
Talkback: Have you tried to do a mortgage work-out? Was it successful or a failure? E-mail email@example.com and your story could be included in an upcoming article.


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Recent Posts
Tag Archives: jericho
The Light at Jericho
Some photos from the weekend, mostly centered around Jericho Beach. Great time with Sam Kim and Amanda Catching, both of whom helped a great deal here. The photo through the wooden railing was only possible with Sam's flash chicanery, and … Continue reading
Posted in Photography Tagged beach, City, experimental, jericho, photography, photos, skyline, Vancouver Leave a comment


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...and Chairman Mao he loves the Repitition...
I hate to do this, but let's revisit the Immutable Law of Firing the Head Coach. From not quite one year ago, when I wrote the following on the idea of firing Tom Soehn:
My answers at this time:
Based on the answers to the questions above, I would then summarize with the big question: Do you believe it is unlikely that this team will perform at an acceptable level in the future?
- Has the coach permanently lost the team? A team that just doesn't put stock into their coach means you either change the team, or change the coach. One of those is feasible.
- Is the coach consistently outsmarted? Even if the coach has the ear of the team, it makes little difference if what he tells them to do will always be ineffective from week to week.
- Is the coach adapting and improving when things are bad? There's a time to stay the course, but even if you know what you want to do, and it isn't showing up on the pitch, you need to adapt to get results. The line between persistent and obtuse can be a small thing.
- Is the team performing better or worse as time goes on? Changes made in training or personnel must show up in better results on the field, or they are useless.
- Is there a better option out there? If you're going to change the coach, you better have a strategy for what comes next.
- Are there mitigating circumstances, such as injuries, that might mean we're not seeing a true reflection of the performance of the team? Look, sometimes you're just unlucky, and it is stupid to make a huge change just because the breaks aren't going your way.
- Do we really have an accurate picture of how the team is performing? Similar to #6 above,but more of a caution about the danger of small sample sizes.
1. No.
2. Not yet, but let's keep watching this. The worst thing may be if Soehn is outsmarting himself.
3. Too soon to tell, but let's reconvene after Thursday.
4. Too soon to tell, but let's reconvene after Thursday.
5. Some people think so.
6. No.
7. Yes.
Based on the checklist, that's three things not in Soehn's favor (#s 5, 6, and 7) and one supporting him (#1). There are three undecided questions. With that, we come to the big question.
BIG QUESTION: Right now, I am still more hopeful about the season than despondent. We've had two league losses, but we've also seen some good play and good results (two international wins, one league).
So to summarize, it ain't time to start the SOEHN OUT!!11!!!1!eleventy!!!1! posts, but it ain't too early to think about what would need to happen to make that time arrive. And that, not to put too fine a point on it, sucks. My sense is that we get through this, that this is just one of those periodic phases. My concern is a voice in the back of mind saying of course, that's what you'd like to believe...
Labels: Tom Soehn


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Here are a few links to make your weekend a little more enjoyable.
Parenting... @ The Vanilla Tulip.
The Guy Behind the Camera... @ Much Love, Illy.
A sweet post about a wife who is still falling for her guy... @ Just Dawnelle.
A first tattoo (since I secretively wish I had one)... @ Take Heart.
The outfit... @ Cara Loren.
Enjoy your weekend! I will be hosting a great group of ladies at my house, enjoying a wedding, and spending some alone time with my hubby.


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When travellers think about Tasmania holidays, beaches, wilderness, wine, seafood and cheese come to mind. The island is famous not only for its stunning beauty but also for the fresh, local produce.
But Tassie is not limited to landscape and food. It has beautiful, historic cities and they are also worth a visit. Or more.
Below is our take on Hobart.
We only stayed there for two days which is definitely not enough. And made some mistakes in planning our trip and not researaching enough.
But some of our mistakes can help you with your planning.
The best way to explore is to drive around to visit the city and the attractions close to it.
But if you don't want to drive and prefer a coach experience, click on the images on the right to check out the tours offered by Viator in and around Hobart.
Plan to fly to Hobart early in the morning. By around 10 am you can be comfortably sitting in your rented car, making the 15-20 minutes drive into the city.
Hobart is the second oldest city in Australia and is said to be the second driest capital city in the country after Adelaide.
We do not relate to this as we copped heavy rain on both afternoons spent in Hobart. But the mornings were great.
Mount Wellington is one of the best attractions of Hobart. Click on the image below to read more about it and about how to get there.
The mount is 1271 m high and only half an hour by car from the centre of Hobart.
But Mount Wellington is not the only great lookout in this city.
There's another one at Rosny Hill, Montague Bay. You can't miss it. We went there when we left Hobart, in the morning.
Hobart lies on the Derwent estuary and is a lovely city with beautiful historic sandstone buildings as well as newer constructions.
The Sullivans Cove is a splendid waterfront and busy port.
The Parliament of Tasmania is nearby and next to it are the cobblestone streets around the Salamanca area.
Salamanca houses heaps of small art galleries and artists' studios, fine restaurants, a famous market open each Saturday.
There are so many other things to see and do in Hobart but two days are not enough.
If we had been there on a Saturday we could have experienced the buzzing Salamanca markets.
But we weren't there on a Saturday so we can only imagine all the stalls filled with gourmet cheeses, wine, crafts, and the like and the crowds hunting for a treasure or a bargain.
In the absence of the crowds and buzz, a stop at the fountain behind Salamanca works fine.
If we had been there between Christmas and New Year we could have applauded the winning team of the Sydney to Hobart sailing race, welcomed the runner-ups and the less lucky yacht crews.
But we weren't there in December so we can just imagine the harbour bustling with boats, sails, cheers, applauds and sailing gear.
The end of the year marks the city's seven day festival. Seven days of fun, laughter, good life, art, music and of course food. From 28 December to 3 January each year. The name of the festival says it all: the Taste Festival. Taste a lot of food.
Hobart and food get together along very nicely.
If you liked reading about Hobart here are other destinations nearby. Click on the images below to read more and see how to get there.
Like this page?
Click on the images below to see more options for spending a holiday in Tassie:
Travelling along the East Coast
The East Coast
Freycinet Peninsula
Touring the North East
Launceston, Plan Your Visit
Launceston Hotels
Cataract Gorge, Launceston
Cradle Mountain
Cradle Country


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'First drafts' of human protein catalogue published
The first two attempts at a database of every single human protein - the "proteome" - have been made public.
This builds on our knowledge of the genome by showing which genes actually produce proteins in which tissues.
One team in Germany and one spanning the US and India have published their proteome maps in the journal Nature, and on searchable, public websites.
Some of the 17-to-18,000 reported proteins arise from stretches of DNA previously thought to be "non-coding".
Along the vast length of DNA packed inside each of our cells, our genes are the sections which contain the instructions, or code, for making proteins.
"While we have a good idea of what the genome looks like, we didn't know how many of those potentially 20,000 protein-coding genes would actually make protein," said Prof Bernhard Kuester, who led the German team at the University of Technology, Munich.
Unexpected results
To find out, the researchers extracted all of the protein from many different samples of human tissues, as well as a number of cell lines. The proteins in that purified mixture were then chopped into small pieces and a technique called mass spectrometry revealed the sequence of amino acids forming each of those pieces.
With a lot of computing power and patience, these batches of protein fragments can be compared with the human genome to make a map, showing which genes in which tissues are "expressed" and producing protein.
"This is the first inventory, if you like," Prof Kuester told BBC news, "like a dozen years ago with the first draft of the human genome."
And just like the results of the Human Genome Project, these data contain some surprises.
Both groups found hundreds of unexpected proteins, produced by fragments of ancient genes (called "pseudogenes") or by lengths of DNA that were not thought to be genes at all.
As well as the newcomers, there were notable absences. "We have good reason to believe that there are hundreds of known, annotated genes that perhaps are redundant," said Prof Kuester.
The team based in the US and India, led by Prof Akhilesh Pandey of Johns Hopkins University in Baltimore, found evidence for only 84% of the proteins that might be predicted from looking at the genome.
Beyond genetics
Prof Pandey told the BBC it was important to study the proteins themselves, as well as the genes that encode them.
He offered an example of how a researcher, investigating a particular gene, might use one of the new databases: "They can look at the expression and get clues about what it could be doing. For example if a protein is expressed in the foetal gut and not the adult gut, then they might think of some sort of developmental process."
The tissue-by-tissue breakdown could also help scientists trying to figure out the actions and side effects of drugs. By comparing the proteome of various cancer cell lines, Prof Kuester and his team have already identified certain clusters of proteins that could increase or decrease sensitivity to cancer drugs.
Dr Kevin Mills, who uses proteomics to study rare diseases at the UCL Institute of Child Health, agrees that it is crucial to look "beyond genomics" at protein levels and how they vary.
"Genetics can't tell us everything," said Dr Mills, who was not involved in either study. "This is really important. We're not static - we're fluid and dynamic and our proteome changes continually."
Although they had seen each other's work at conferences, both Prof Pandey and Prof Kuester told BBC News they had "no idea" they were headed towards publishing simultaneously. They spoke on the phone last week after discovering that both of their studies would grace the cover of Nature.
"We never saw this as a race to be first," said Prof Kuester. "My interpretation is that when the time is right, somebody's going to just do it. And perhaps two people are going to do it!"
Prof Pandey compared today's joint publication to the first draft of the human genome, which was announced by two different teams in February 2001.
"Although both groups came up with similar numbers of genes, the actual list was different," he said. "We are likely to have less of that confusion, but we are definitely going to benefit from putting the two data sets together."
In the meantime, both sets of results are freely available online: the work of Prof Kuester's team is at proteomicsdb.org and Prof Pandey's team at humanproteomemap.org.


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♥ Peppermint smells great and offers a lovely healing tingle from the peppermint essential oil. Helps clear your mind, good for sinus congestion, herpes, and can even help with headaches. Take a bit of lip balm and use your fingers to rub into your temples. Ahh. {available without cabernet red mica in tube, with red mica in 1/2 ounce tin}
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This lip balm soaks into your lips, offering great healing, moisture and protection.
Ingredients: Organic Vitellaria Nilotica Shea butter (Butyrospermum Parkii), jojoba oil, California Beeswax, pure essential oil, Vitamin E


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In Rivers and Bayelsa State, the failure to publish detailed unit level results at polling stations has increased State-wide tensions, raising local concerns of electoral rigging and voter fraud.
On Our Radar reporters have today shared their own experiences of voting, investigating whether results were published transparently at a local level.
"Room for manipulation"
Flora Asieri, On Our Radar reporter and election monitor in Ogbia, Bayelsa State, suggested that the process in her ward was far from transparent.
"I received the total number of votes on the various parties in unit 1, but only because I was an observer. Party agents were also privy to the information, but the result wasn't pasted on the wall. A copy of the result was given to party agents present. I think this might create room for manipulation at LG or State level. I am sure when the result is out, it will be inflated."
Faith Abraham, in Anibeze, Bayelsa, confirmed that the results were not posted in her ward either. "Results were not posted nor announced in my unit, even in local levels, but no protest has been planned. This could lead to rigging, but if INEC is sincere it will not be rigged."
Bokolo Nimiteinbofa, Bayelsa State, was so concerned about the voting situation in Nembe that he followed the matter up with the local police unit. "They announced the results before everyone in the units, but the results were not posted in all the polling units in Nembe LGA. The police officer [at the station] said there were no manipulations with the ballot boxes after the election in the coalition office at the Nembe City Hall. But I know that with this pattern rigging is possible."
Robert D. Nitabai, in President Jonathan Goodluck's county, Ogbia, commented; "The independent national electoral commission has refused to announce the result in the state and nobody is aware of the idea." At this stage, the LGA results in Bayelsa are yet to be announced.
All eyes on Rivers
On Sunday, APC protestors marched upon INEC's office claiming the result sheets being used by polling officials in several parts of the state were fake. Governor Amaechi refused to be personally accredited because the Presiding Officer in his Polling Unit in Ubima was not able to provide the result sheet upon request.
In Isaac Cotterell's unit of voting (Unit 5 – Abuja), the result sheet was not formally displayed, supporting Governor Amaechi's claim. "A sheet was shown, but it was not displayed on the wall. What they displayed was the sheet that contain the pictures of the candidates."
On Our Radar reporter, Glaad Amadi who covered the protest in Port Harcourt and interviewed local protestors, had this to say; "According to the audio interview l did with APC member, which they claim that election materials was not giving to them. Many people were very angry."
[Picture credit: Glaad Amadi]
Interviewed at the protest, Mr Stephens said, "INEC never produced the results sheet for us so there is NO election in Rivers State. I am from Okrika, Ward 6, materials arrived and they were moved into the personal resident of the PDP Chairman's house. So, we have decided to protest that materials are not acceptable."
Mr. Apliza Adu added, "They did not allow us to vote for our choice! We need them to allow us to vote! We don't know what INEC are saying, but we are here to represent our party."
Nkaiso Akpan, a Rivers resident who was unable to vote due to the fact that she could not travel to her place of registration was frustrated and angry with the system. "I am having a feeling that the elections will be rigged. Why am I saying this? Many people could not vote yesterday, but they were registered. What happens to these votes? You may find it hard to believe, but I still have hope."
Contrary to Amaechi's reports, however, Best Uso, reporting from Rivers State, confirmed yesterday that the results sheets were, in fact, properly displayed in the units she visited, but that the people are now concerned about the lack of consistency across the State.
"Result sheets were properly displayed in some of the polling units I visited at Ward 3 and 4, Onelga, but after voting and counting the result sheet was not pasted. We here that there was no result sheet at most polling units in Rivers. I think that it will surely affect the credibility of the process. The people in Erema are divided over the election. Yes, we are very worried too. The secrecy of the result has really affected the credibility of the process."
Many in the Niger Delta have urged caution in response to these accusations by the APC, claiming this should not mar the democratic process.
"The PDP has claimed the protest in Rivers State was sponsored and early on Sunday morning there were buses in Omoku which conveyed people to the protest," commented Best Uso. Damasus Henry lamenting the current situation urged calm, placing his faith in the agreed upon process; "we are waiting for the results from INEC. This is a crucial time – they have to take it carefully not to make a mistake."


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Yamaha Outdoors Tips — Waterhole Pronghorns
My ground blind stands out from a long way off, but was placed far enough in advance of my hunt that the pronghorn became accustomed to it.
By Bob Humphrey
Last month I talked about tactics for decoying pronghorns. But that's not the only method for duping these keen-eyed prairie speedsters, or for that matter the easiest. In terms of effort expended, the easiest by far is sitting over a waterhole. And for a bowhunter, it's also the most productive. What follows are a few tips to improve your odds.
1. Set your blinds well in advance of your hunt. This gives speed goats time to become accustomed to them. A couple years ago I arrived on a Montana hunt the day the guide put out our blinds. For the next three days all hunters reported the same thing. The pronghorn would approach waterholes only to within a hundred yards or so, stopping frequently to stare at the blinds before eventually heading off to other waterholes without blinds. The year before I hunted a different outfit where the blinds had been out weeks ahead of our hunt, and the goats never hesitated coming to our waterholes.
2. Hunt the heat. Hunt all day if you like, but your best odds will come during the hottest part of the day. Pronghorn are much more diurnal than whitetails, moving mostly during daylight hours. This makes dawn and dusk particularly important feeding times. As the sun and the temperatures climb, goats become less active and head for water.
3. Approach carefully. The one advantage to all-day hunting is you can approach in the dark, before the sharpest mammalian eyes on the continent can spot you. If you opt for hunting just peak times, you're far better off having someone drive you to your blind than walking in. Pronghorn aren't nearly as bothered by the sight of ranch vehicles and ATVs as by the sight of a human on foot.
4. Whether you hunt all day, or just mid-day, make yourself comfortable. Bring a comfortable chair with a seat cushion and a solid back. Make sure you have plenty of water to stay hydrated, and food to stave off hunger. Be very conscientious about odor control and wear a base layer of moisture-wicking material.
5. Stay Alert. It's easy, and tempting to nod off during the heat of the day when the action is slow. But things can happen fast around waterholes. Antelope are the fastest land animals in North America, and once they make up their mind to visit a certain waterhole, they waste little time getting there, or sticking around when their belly is full.


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When we went to the Colca Canyon (in Peru), we saw two Andean condors. We wanted to learn more about them, so we looked up information about them, and made this post.
Its wingspan is up to 10 1/2 feet. It has the longest wingspan of any bird. It's the biggest bird that can fly. Its weight is up to 33 pounds. The Andean condor's body length is 4 feet (average) when it is fully grown (almost as big as Jason). They need wind to fly, because they are so heavy. They glide on wind currents. Because of this, they need to live in windy areas. They live along the coast of western South America, and in the Andes mountains.
Condors are carnivores. They are scavengers, and they act like a clean-up crew, by cleaning up the leftovers from dead animals. They're actually a type of vulture.
They are endangered, and they only have one chick every two years. The Andean condor is in better shape than its California condor cousin. The Andean condor gets some help through breeding programs.
|Andean Condor we saw in Colca Canyon, Peru
|Close-up of Condor


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For generations, people have worked hard and saved to buy their dream home. They start small and as they add to their family, they buy bigger homes. The kids go off to college and then they start thinking about their dream home. Is that still a reality today ?
While housing decisions remain as some of the most important decisions facing Americans, it is not unanimously assumed that homeownership is the best financial course of action. Click here to read more


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Do you tweet? We do, and we are so appreciative of the great community we have found on Twitter. We wanted to do something a little extra special, so we paired up with Mom it Forward to host a Twitter party. It's called #gno (perhaps you have heard of it before) and it is a great way to gather on Twitter and discuss a topic in depth.
Join us on Twitter this Monday, June 28 from 9-11 ET (8CT, 7MT, 6PT) to learn about starting, growing, and supporting that wonderful thing called a small business. We'll discuss everything from causes and communities to products and promotion. If you haven't joined us before, the pace is fast, the knowledge flows freely, and the fun is simply indescribable.
Check out the Mom it Forward site for all the event details and to RSVP.
Plus you won't want to miss this because we are giving away a great prize!
Because we know that all budding entrepreneurs should have cool gadgets, we are giving one lucky winner a $200 Apple Gift Card! Get that iPod, iTouch, or iPhone you've been dreaming about. Plus, we are giving you a cool Grommet! To protect your cool new gizmo, the winner will also receive an Aquapac waterproof MP3 case with headphones.
For all the prize info and details on how to enter- head on over to Mom it Forward.
Hope to see (and tweet!) with you on Monday night!


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Add to your cart today for a quote, or stop by our Bay Area shop and see us!


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THE BBC have once again decided to boycott Rangers after the club reimposed a ban on sports reporter Chris McLaughlin, according to The Herald.
A previous boycott was dropped last August after discussions between the two parties saw Mr McLaughlin allowed to entry Ibrox Stadium once again.
The last dispute lasted a month and ended in August, with BBC relying on agency staff to cover matches at Ibrox in the time between.
Relations remained amicable until last weekend when the BBC reporter was once again informed he wouldn't be allowed to enter the ground. This occurred prior to Rangers' 4-1 win over Livingston.
The BBC insist they've been left with no choice but to start a new boycott as they stand by their employee.
BBC Scotland said: "We are disappointed that Rangers took the decision to ban our reporter Chris McLaughlin from Ibrox. We believe it is unjustifiable and we stand by the integrity and the quality of our journalism.
"We will continue to report on Rangers both on and off the pitch and will feature match action where appropriate but, until this issue is resolved, we will not be sending journalists to Ibrox or attending Rangers' press conferences."
The club have responded by insisting the move was made to ensure "fairness" from the broadcaster.
Rangers said: "This is about balance and fairness. It is Rangers' view that after having asked for, and having been promised, exactly that - nothing more, and certainly not favour from this or any other reporter - it has not been forthcoming.
"The BBC know they are welcome but once again they, in their wisdom, have chosen not to attend Ibrox thereby denying licence payers the opportunity to see and hear from Rangers on a publicly-funded platform which is supposed to be for everyone. Rangers fans are entitled to ask if this is an abuse of the BBC's privileged position."
• The 25 biggest wins in the Scottish top flight
• Rumour Mill: Aston Villa want Stefan Johansen | Ann Budge fumes at SPFL | Scottish football draft?
• Rangers will not resort to panic buys, insists Mark Waburton
• Keep up to date with all our sport news on The Scotsman's Sport page on Facebook
• Follow @ScotsmanSport for the latest sports news and comment


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Butternut Squash Soup is something I really enjoy eating. It is not a dish I have ever tried making. When I got my Hometown Harvest bag I found a nice sized organic squash tucked inside. Originally I thought, I will chop this up and sauté it with some olive oil and zucchini. My friend however challenged me to step outside my cooking comfort zone and make a soup using my squash.
I always get nervous with a new recipe. If you screw it up then dinner is ruined and if you're a perfectionist like me you feel like you are a terrible person!
Despite the apprehension and fear I was about to waste a beautiful squash I rolled my sleeves up and got cooking.
- 1/2 Spanish Onion (chopped)
- 6 Cloves of Garlic (chopped)
- 5 Medium Carrots (chopped)
- Chicken Broth
- 1 Large Squash (diced)
- Extra Virgin Olive Oil
- Thyme
- Basil
- Garlic Powder
- Sea Salt
- Pepper
- Heat olive oil and sauté the onion, garlic, and carrots until tender
- Add the squash, chicken broth, thyme, basil, garlic powder, sea salt, and pepper to taste.
- Simmer until tender
- Puree with a stick blender until smooth
I think it turned out great! The family loved it and asked for seconds so I would call it a success.
One of the fun things about having Hometown Harvest as a sponsor is I will be pushed to try and create new recipes. I am looking forward to the challenge!
What is your favorite Squash recipe?