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The following is an excerpt from the novel
The Poacher's Son by Paul Doiron
A black bear had gotten into a pigpen out on the Beechwood Road, and it had run off with a pig. There were bear tracks in the mud outside the broken fence and drag marks that led through the weeds into the second-growth timber behind the farm. The man who owned the pig stood behind me as I shined my flashlight on the empty pen. He had called me out of bed to drive over here, and his voice over the phone had been thin and breathless, as if he'd just run up a hill.
"Warden Bowditch," he said, "I never seen nothing like it."
His graying hair was wet from the rain that had just stopped falling. He wore an old undershirt stretched tight over his swollen belly and a pair of wash-faded jeans that hugged his hips and exposed an inch of white skin above the waistband. He carried a .22 caliber rifle over his shoulder, and he was holding a sixteen-ounce can of Miller High Life. His eyes were as red as a couple of smashed grapes.
It was a hot, humid night in early August. The thunderstorm that had just finished drenching midcoast Maine, five hours north of Boston, was moving quickly out to sea. A quarter moon kept appearing and disappearing behind raggedy, fast-moving clouds that trailed behind the storm like the tail of a kite. Crickets chirruped by the hundreds from the wet grass, and far off in the pines I heard a great-horned owl.
The bear had clawed apart the plank fence as if it were a dollhouse, leaving a pile of splintered boards where the gate had been.
"Tell me what happened, Mr. Thompson," I said, moving the beam of the flashlight over the puddled ground.
"Call me Bud."
"What happened, Bud?"
"That bear just scooped him up like he was a rag doll."
I shined the light against the farmhouse. It was a clapboard frame building with a broken-backed barn that looked about to collapse and a chicken coop and tool shed out back. Behind the house was a dense stand of second-growth birch and alder with pine woods beyond. The bear had only to cross thirty feet of open field to get to the pigpen.
"You said you saw the bear attack him?"
"Heard it first. I was inside watching the TV when Pork Chop started screaming. I mean squealing. But you know it sounded like screaming." He slapped a mosquito on his neck. "Anyhow, I looked out the window, but it was raining, and I couldn't see a damned thing on account of how dark it was. Then I heard wood snapping and Pork Chop screaming and I grabbed my gun and came running out here in the rain. That's when I seen it."
Now that I was close to him I could smell the heavy surge of beer on his breath. "Go on."
"Well, it was a bear. A big one. I didn't know there were bears that big around here. It was reaching over the fence with its paw, leaning on the fence, and the boards were just snapping under its weight. And poor Pork Chop was back in the corner, trying to get away, but it wasn't any use. The bear just hooked him with its claws and pulled him in."
"How come you didn't shoot it?"
"That's the thing of it. I did, but I must have forgot to load it." He rubbed his hand across his wet eyes and shifted his weight from one foot to the other. "It wouldn't have really attacked me, would it?"
"I doubt it." There are no recorded reports of fatal black bear attacks on humans in the state of Maine, but I'd read of fatalities in Ontario and Quebec, and it was probably only a matter of time until something happened here. "You were right not to provoke it, though. If you'd shot the bear with a .22 you probably wouldn't have killed it, and there's nothing more dangerous than a wounded animal."
Except a drunk with a gun, said a voice in my head.
"I loved that pig," He swung the rifle off his shoulder and held it up by the strap. "I wish I'd shot that son of a bitch."
"You shouldn't handle a firearm when you've been drinking, Bud."
"He was the smartest pig I ever had!"
I raised my flashlight so the beam caught him in the eyes. "Do you live alone here?"
Whether it was the light or the question that sobered him I don't know, but he blinked and ran his tongue along his cracked lower lip and looked at me with renewed attention.
"My wife's moved out for a while," he said. "But she'll be back before too long." His expression turned pleading. "You don't need to talk to her, do you?"
"No. I just wondered if anyone else saw what happened."
He scratched the mosquito bite on his neck. "I got an old dog inside. But he's deaf and just about blind."
"I meant another person. You said you hadn't seen the bear around here before. Is that right?"
"I didn't even know there were bears this near the coast. You don't think it'll come back here, do you?"
"Probably not since you don't have another pig. But I see you keep some hens." I gestured with my flashlight towards the chicken coop, using the beam to draw his attention. "The bear might come back for the hens, although I doubt it will. Why don't you go inside and put that gun away. I want to take a look in the woods."
He glanced at the trees and shivered. "Be careful!"
I watched him shuffle away into the house, head hanging, beer in hand. No wonder his wife left him, I thought. Then I remembered my own empty bed back home and I stopped feeling so superior. Sarah had been gone exactly fifty-five days. Earlier, I'd gone to bed thinking that it would be fifty-six days when I woke up, but that was before Thompson called. So here it was fifty-five days again.
I got to work measuring the paw prints in the mud. They resembled the tracks a barefoot person might leave walking along a beach. Judging by the distance between the front and hind feet, I figured it was a medium-sized bear, two hundred pounds or so.
I followed the drag marks through the field, and the rainwater that clung to the weeds soaked through my pants legs. The trail disappeared into the low bushes — scrub birch and speckled alder and sumac — that grew along the edge of the forest. I directed my light into the wet mass of leaves, half-expecting to see the beam reflected back by the eye shine of the bear's retinas.
Thompson's description suggested a curious young bear expanding its diet from berries and beechnuts to the other white meat. Probably the animal was miles away by now, having gorged itself on Thompson's beloved pig. Still, I found myself listening for anything to indicate the bear might be nearby. A mosquito whined in my ear. Ahead of me and all around, I heard trees dripping in the darkness. Switching the flashlight from my right hand to my left, I reached down to touch the grip of my sidearm. It was a heavy SIG Sauer P226 .357 that I had never fired except at a practice range.
I pushed my way into the forest. Beaded rainwater spilled off the leaves onto my shoulders and face. I was drenched in an instant.
After a few steps, I was through the green wall of bushes and saplings at the edge of the wood. Beneath the trees the air was still and heavy with the smell of growing things — as humid as a hothouse. I made an arc with the bulls-eyed flashlight beam along the forest floor, looking for drag marks. But the soft carpet of moss and pine needles had absorbed all traces of the bear's passing, and I saw no more blood drops. I wandered deeper into the woods, searching.
I found the pig a hundred yards in.
It lay on its side in a puddle of congealing blood. Its throat had been torn out, and its haunches had been chewed to a red pulp. The bear had not attempted to bury the carcass or cover it with leaves. It was possible it had heard me coming.
I switched off the flashlight and stood under the dripping trees, listening. I knew retired game wardens and ancient trappers who could hear the rustle a buck made passing through alders across a stream. Men who were so at one with the woods that they didn't fully exist among other human beings but were only truly themselves outdoors. Maybe someday I'd be one of those old woodsmen. But for the moment I was still a twenty-four-year-old rookie, less than a year on the job, and my senses told me nothing about where the bear was.
I turned the flashlight back on. Then I went up to the house to tell poor Bud Thompson what I had found.
By the time I got home it was well past midnight. I'd left the light on outside the screen door and moths were swirling about, butting themselves stupidly against the glass.
As I stepped inside, I was surprised again by my empty house. Sarah had taken most of the furniture with her when she moved out. It always startled me, coming home, to see how little I actually owned. Stacks of books and newspapers, a steel gun cabinet, fallen antlers I had collected in the snow.
Moonlight shone in through the windows, bright enough to see by, so I left the lights off as I moved through the house, shedding my damp shirt and boots as I went. I unbuckled my gun belt and put it away, then wandered into the kitchen. Frosty light spilled out of the refrigerator when I swung the door open. I found a can of beer and pressed it against my forehead as I made my way out into the living room.
I cracked open the beer and toasted Bud Thompson and Mike Bowditch — two womenless men dousing our loneliness with alcohol. Except that unlike Thompson, I had chosen to be alone. An empty house was what I'd wanted all along, even if it had taken Sarah years to realize it.
She'd hung in there with me from Colby College, where we'd met, through the Maine Criminal Justice Academy and the Maine Warden School and my eight weeks of field training. She toughed it out, thinking it was a phase I was going through, that eventually I'd go to law school like we'd talked about and become a prosecutor and maybe someday a judge. But it wasn't a phase, and it was only after I had gotten posted in coastal Knox County that she realized that being a game warden was a twenty-four-a-day, seven-days-a-week way of life, and for reasons neither of us fully understood, I'd chosen it over her.
So she left.
And I missed her — and counted the days since she'd gone away. But I was relieved, too. Relieved that I no longer had to justify my emotions to anyone else. I could spend the night alone in the woods searching for a dead pig and be content in a way that made absolutely no sense to anyone who wasn't a game warden. With Sarah gone, I could love this solitary and morbid profession without excuses and not have to look too deeply into the dark of myself.
That was when I noticed a small blinking light across the room.
It hadn't occurred to me to check my answering machine. I'd been gone only an hour and a half, and most everyone I knew had my pager number if they needed to get a hold of me. My first thought was that it had something to do with the bear. Maybe someone else had seen it outside their house, or maybe it had gotten into another pigpen.
When I pushed play there was the raspy sound of breathing on the other end for a while before a man finally spoke: "Mike? Hello? Pick up if you're there." There was a long pause. Then, in the background, came a woman's voice: "Is he there?" The man said: "No, goddamn it! He's not home!" Followed by a disconnect.
I didn't recognize the woman, but the other voice was deep and monotone, just like mine, and hearing it again after two years was enough to start my pulse racing. Why was my father calling after all this time? What could he possibly want from me now?
I stood still in the dark while the tape rewound.
© 2010 Paul Doiron


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Welcome to the graduate page of Chulalongkorn Chemical Engineering. We are actively engaged in state-of-the-art research, offering students a unique blend of research and educational opportunities that seek to address challenging problems faced by new, emerging industries. One major source of strength for the department is the high quality of its faculty and the graduate student body. In 2006, there were 148 full-time graduate students enrolled in our programs. These students represent a wide spectrum of backgrounds; among them are the top students from universities in Thailand and other neighboring countries.
Thank you for your interest in the Chemical Engineering Undergraduate and Graduate Programs at Chulalongkorn University. The Department of Chemical Engineering at Chulalongkorn University is the dynamic player on the forefront of chemical engineering technologies in the region today. We are home to a motivated faculty, involved in both pioneering chemical engineering academics and assisting Thailand industries. If you want to study chemical engineering, you should seriously consider Chulalongkorn Chemical Engineering. For example:

subset: commoncrawl


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TB Research Perspectives
A Brief Project Overview
Tuberculosis has afflicted humanity for thousands of years. In 2009 there will be more cases of TB and more TB deaths than in any other year in recorded history. The last effective test for diagnosing latent tuberculosis was developed in 1891. The last vaccine for the prevention of TB was developed in 1921. The most recent first-line drug class for the treatment of TB was developed in 1967, more than 40 years ago. Humanity is now facing multiple-drug-resistant and extremely-drug-resistant strains of tuberculosis for which effective treatment may be vanishing. According to the World Health Organization as of March 2009, the total number cases on record for the most recent year for which we have complete statistics is over 5.5 million. All of this makes a review of the science of combating this ancient enemy an urgent priority. Compare this with the attention paid to the recent outbreak of "Swine Flu" or H1N1.
We hope to place this and the renewed relevance of the classic research into the prevention and cure of tuberculosis into historical perspective. This project will be carried out with the assistance and cooperation of the Division of Infectious Diseases and Immunology of the Department of Medicine at the NYU School of Medicine, Dr. Joel Ernst, Director.
The principle components of the proposed website are:
I. The 40 research papers written between 1890 and 1980 comprising the most important "classic" scientific papers on the disease
II. A section for people directly concerned with the disease: researchers, clinicians and patients; using interactive social Web technologies, this is intended to be a forum for all concerned parties as well as a repository of writings and graphic materials of general as well as scientific interest
III. A timeline combining a graphic representation of the highlights of the recent human experience of the disease from the point of view of patients, public policy and science
IV. Links to other related efforts
No website presently exists combining the science of tuberculosis research and its human impact. By making the classic TB research papers available in a single place—as a first step—will be an important contribution to a nuanced understanding of the disease for researchers. Beyond that, we wish to embed this research into the context of the present growing threat of the disease. We can add further dimensions by tracing the historical path we have taken. This will include the great advances of the last century, the false belief that the disease had been defeated, and the missteps in not adequately prioritizing the treatment of the disease in areas where people have been most susceptible to infection. This has taken us to where we are today, with new strains threatening to overwhelm our defenses.
The recent outbreak of "swine flu" or H1N1 as reawakened many to the dangers of a dangerous infectious disease. However H1N1 is a minor threat, at the moment, compared to the magnitude of the danger of tuberculosis in its new forms. We hope our website will address these concerns, encourage research and broaden our general understanding of the relationship of humanity to one of its oldest and most dangerous enemies.


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We have had au pairs living with us for the last six years. It was a choice that we made just before Maya was diagnosed with autism, figuring it was better for her to come home after school rather than have to adjust and cope in an after school program, once Maya was diagnosed we knew that an after school daycare for special needs kids was not really something that existed.
It's been a win-win for us. And before you think we are just spoiled, upper class people who don't want to raise our kids, we aren't. We are quite atypical from most families that have au pairs. While we are comfortable financially and have a nice house, we live in a very average home, in a neighborhood with people who are school teachers, electricians, secretaries auto mechanics and the like. We definitely do not live among the country club set, no CEOs, Diplomats,
Ponzi Schemers or Hedge Fund Managers over here. We definitely have to think about where and how we spend our money. We go without certain things in order to have an au pair. We take less vacations than your average European family and we also gave up having a second car. So, we are not just some rich family in a Range Rover talking about how hard it is to find good help.
This is a conscious choice we have made for our family. We gladly made and continue to make that choice for our girl, because having an au pair is better for her development, it's more comfortable with us and fits better into our lifestyle, helps reduce the inevitable stresses from raising a special needs child and most importantly, our daughter, as an only child, it gives her at least a taste of the experience of having an older sibling to be with, live with, pal around with and form a bond with.
This is a conscious choice we have made for our family. We gladly made and continue to make that choice for our girl, because having an au pair is better for her development, it's more comfortable with us and fits better into our lifestyle, helps reduce the inevitable stresses from raising a special needs child and most importantly, our daughter, as an only child, it gives her at least a taste of the experience of having an older sibling to be with, live with, pal around with and form a bond with.
We've adjusted pretty easily to having someone living with us (which is the number one question I get from people about having an au pair) and now it just feels normal to have another member of our family.
There are certain adjustments you need to make as a family with live in help. There is the whole thing that you have to adjust to someone actually living in your house and who has different ways of doing things than you do. You also have to accept that there will always be things that you feel they don't do as well or as thoroughly as you, because that is just the reality of having household help. It's the overall package which is important rather than any individual task. The fact that you have someone taking your children under their wing and helping you with the day to day of childcare, of taking the children to where they need to go and helping you keep house counts for a lot. I always love coming home from work each day and having my living room and kitchen cleaned up and tidy, our beds made and things more or less put away. Believe me, it would not look that way if the system were dependent on me.
We've had 4 au pairs over the years and will likely have a few more. Leo and I have decided to continue with an au pair at least until Maya finishes primary school and then based on where she is with her development and what her life looks like then, we will decide if we will continue.
We've loved our au pairs, they have all been very kind people, although with very different personalities and Maya has adored each one of them. Of course, like anyone, you like some traits better in one person than another and vice versa. We've been very lucky, because despite whatever personality ups and downs there have been, every single one of our au pairs has been kind and caring people, who've loved our girl and have done their best to do things the way
we Leo I like.
Not that our au pairs over the years haven't done things that have irritated us from time to time or had certain habits in the way they did things that we would have preferred were handled in a different way but that is always going to be true when you have relationships with people. If you keep a scorecard, you are going to get less out of the relationship. If you build trust and accept that one another are not perfect, you can find your way. We, like any other family have certain deal breakers and I stress the importance of those and mostly for the rest, I let it go, as I am certain there are certain things we (mostly I) do which annoy them from time to time and they let that go as well. Give and take.
Au pairs that come from a foreign country often become friends with other au pairs, and you know what that means. They compare their host families. So, we've had a lot of au pairs come in and out of our house and I have heard a lot of stories about host families. Many are just funny stories, but we have heard more than our fair share of truly shocking things, things that really show a lack of compassion, responsibility and downright abuse.
The Netherlands has very strict rules regarding au pairs, partially because there were so many cases of reported abuse by host families that our immigration authorities just got a whole lot stricter. Even with those rules in place, however, it seems like a lot of families don't follow those rules and take advantage of their au pair's youth and naiveté. Au pairs eager to please and make a good impression, have a good experience are often reluctant to question the orders of their host families.
Still, the things I see are often in flagrant violation of the rules and in my view, common decency. An au pair is not a job in the classic sense, the au pair doesn't get a salary, he/she gets room/board and a small stipend each month. It's supposed to be a cultural exchange and you are supposed to treat the au pair as if they were an older sibling to your own children. That's not to say that it's not right to give them responsibilities and require nothing, but you really should play fair. These people are caring for your children, however you treat them will be reflected back to you in how the au pair cares for your own kids.
These are just some of the things I have seen/heard about over the years:
-Not giving the au pair their own room but making them sleep in a public room, like the dining room, without any privacy. One au pair told me that her room is detached from the rest of the house and doesn't have its own bathroom and the family has said she is not allowed to come into the house when they are there, even to use the bathroom. They've given her three buckets and toilet paper to keep in her room. Ummm, guess what, it's not a barnyard animal you're keeping, it's a human being. How the f*ck would you like to pee in a bucket? (the rule is that the au pair needs their own room (and their own bathroom if possible)).
-Making the au pair work 6 or 7 days per week (5 is the max)
-Giving the au pair the responsibility for all the shopping, cooking, cleaning and total care of the children (totally not allowed, the immigration authorities are very specific about what you can and cannot ask from an au pair in order to make sure that the responsibility stays with the parents, down to the fact that you can ask them to vacuum but you can't ask them to clean your stove or oven).
-Routinely expecting the au pair to watch the children 10-12 hours per day or more (8 hours per day is the max)
-Not giving the au pair any weekends off (they must have at least one per month)
-Calling the au pairs on their day off and expecting them to return home to work (not allowed, days off must be scheduled, you can change the schedule, but that should be done in consultation with the au pair and certainly NOT once the day off has begun).
-Not providing meals on the au pair's day off (full room and board is the agreement)
-Making the au pair do the family's entire laundry including ironing (kids laundry only)
-Making the au pair taking care of all night feedings for a newborn baby (not strictly against the rules but probably not very ethical unless the au pair's night hours are factored into the hours she is allowed to work (which means for a newborn probably a pretty light day schedule), and this particular au pair gets up in the night and then takes the older children to school and picks them up. Not sure what the schedule is there, but this person is supposed to help the parents, not raise the sodding children.
While it is the host family's obligation to ensure that they follow the rules, both the official rules but also the rules of common decency, I find it hard to believe that many au pairs feel like anything other than a servant. Still an au pair has to know their rights. Many host families think that because they are supporting the au pair financially they can ask anything and everything and like I said, they often take advantage of the au pair's naiveté. Au pairs should know their rights. Certainly there is room for flexibility, so if you for instance like doing laundry, and you agree, sure, go ahead but to me the problem is where a host family just expects, expects and expects and gives no flexibility or leeway of their own. In some capacity by not understanding the rules and gently raising questions on these things, they confirm to their host families that indeed this treatment is okay.
We relish the relationship we have had with all our au pairs and love that they have loved our daughter so much. They truly are members of our extended family and I hate to see, what I think are mostly good natured people being taken advantage of.
Au pair is not French for indentured servant.


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{Wordless Wednesdays}: Curbside Cafe and Wine Bar
Labels: affordable, all-day-breakfast, biopolis, Brownies, brunch, cafe, Cheesecake, coffee, desserts, milkshakes · Posted by Sihan at 8/13/2014 11:22:00 pm
Rounding off the National Day weekend with the family over a round of guilty pleasures. Spam fries, Red velvet cheesecake chocolate brownie, homemade apple pie and a smorgasbord of sticky milkshakes.
Curbside Cafe & Wine Bar
21 Biopolis Drive
Nucleous #01-21
Singapore 138567
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text: Around 3.5 million people use Cairo's metro everyday. Work is under way on providing better services and developing a line which will take passengers to the airport, pleasing Egyptians who consider the transport to be one of the only functional services in the busy metropolis. Al Jazeera's Rawya Rageh reports from Cairo. SOURCE: Al Jazeera Middle East


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Buying primary goods in bulk is a great way to save money, but we often hesitate if we have enough room and good conditions for storing everything in a way the products would stay fresh. That's the main reason nowadays people reach out for the processed, preservative-full goods that likely drive up the price of our cart.
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Best Food Dehydrator for 2017
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Received 4.9 Starts out of 5 in Customer Reviews
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Their food dehydrator uses a ten tray system that allows you to create multiple batches of dehydrated foods at a time. The digital temperature settings make this dehydrator novice friendly as it shows you precise drying times and temperatures that allows you to monitor the process for perfect results every time. The transparent window allows for careful monitoring of your progress for perfect results every time.
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Enjoy the homemade easiest healthiest snacks, preserve foods, without additives, made with BPA free machine. Rear-mounted fan is designed to promote even drying without overheating, and the adjustable thermostat with automatic shutoff ensures that foods are dehydrated at their optimal temperature and crispiness. 6 Spacious, (13″ X 12″) adjustable stainless steel drying racks, 2 plastic fine mesh trays,2 nonstick trays, 1 set oven mitts, to accommodate a wide variety of fruits, herbs, vegetables, and meats, great for large families, gardeners, sportsmen, outdoor hobbyists, health-conscious enthusiast. Help you choose your desire temperature and time. Up to 19.5 hours dry time. Choose drying temperatures from 95º F to 158º F. Countdown timer. Perfect for dried fruit slices, long-lasting dried herbs, delicious beef Jerky and more. Also a perfect way to preserve foods. For a fraction the price of commercial.
The Magic mill dehydrator is designed to serve you with all you need to have the joy of hydrate food for your health and taste
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If you want to dry fruits, vegetables, and jerky in hours instead of days. The unit's patented Converga-Flow drying system forces air down the exterior pressurized chamber, then horizontally across each individual tray, converging in the center, for fast, even, and nutritious drying.
Flavors don't mix, and there's no need to rotate the trays. It's top-mounted fan eliminates the worry of liquids dripping into the heater chamber, and an opaque Vita-Save exterior helps block harmful lights in order to retain more of the food's nutrients and vitamins during the drying process. Four trays come included, but the unit can be expanded to 12 trays (additional trays sold separately) for drying larger quantities at one time. Accessories include one fruit roll sheet, perfect for drying semi-liquids like soups, sauces, and fruit rolls; one Clean-A-Screen flexible screens, which allow for easy drying of small items such as herbs, spices and potpourri and one original jerky spice packets for making jerky. Other highlights include a bale handle for removing the power head, dishwasher-safe parts, and an instruction manual for getting started.
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Press Play: Four Tet, Wolfgang Voigt, Jonwayne, Robot Koch, and More
It's a wild mix of sounds and styles in today's edition of Press Play, with heavyweights like Four Tet and Wolfgang Voigt dropping frequencies alongside younger talents such as Suzanne Kraft, Michna, Total Freedom, Jonwayne, and Robot Koch, among plenty of others. Give it all a spin after the jump.
A burly reworking of a standout tune from Four Tet's brand-new Pink LP from up-and-coming tunesmith Happa.
Kompakt boss Wolfgang Voigt shares his "HardTranceAtlanticXSMix" of a track he produced with Jörg Burger as Mohn.
LA beatmaker Jonwayne claims to be "getting the funk out" on his latest tune to surface online, and we wholeheartedly agree.
Following his recent collaboration with Rain Dog, Berlin producer Robot Koch unveils another track from his Cosmic Waves EP for Project: Mooncircle, the Kuhn-featuring "Sludge."
Here's another leak from Michna's forthcoming EP for Ghostly, the airy and bright "Through the City on the Edge of Forever."
The latest signee on New York's UNO label, Aquarian evokes the soul of Drexciyan electro and techno on "Motherisk," the hard-edged first leak from his forthcoming record.
Suzanne Kraft's buoyant "Horoscope" tune is lifted from the DJ/producer's forthcoming EP for Young Adults.
Palace's wobbly bassline tune "Trust" is coming soon from Unknown to the Unknown.
LA DJ/producer and Fade to Mind cohort Total Freedom nabs Kelela's vocal from Teengirl Fantasy's new "EFX" single, and makes his own slow-bouncing tune with her soulful melodies.
UK label Four40 shares this deep remix of I Killed Kenny's "Let's Go (feat. Jamie George)" by Shorterz.
The artist formely known as Beacon, Lorenz System follows up his recent freebie, "2K," with "2K4O," a punchy and glistening cut that further exhibits the producer's budding love for freestyle beats.


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By Lise Alves, Senior Contributing Reporter
SÃO PAULO, BRAZIL – The non-governmental group Human Rights Watch (HRW) stated in its latest Global Report that the overcrowding in Brazilian prisons and the high number of extrajudicial killings at the hands of Brazilian police forces contribute to a cycle of violence in Brazil.
For the advocacy group, although advances in the human rights area have been seen, drug laws must be changed and security agents guilty of indiscriminate murders must be punished.
According to the report over sixty percent of men and thirty percent of women today in Brazilian prisons are there for drug-related offenses. "[Drug] laws increased penalties for trafficking and has left a lot of room for interpretation, leaving up to police the interpretation of who is a user and who is trafficker," said the 687-page document about the Brazilian prison system.
In addition to the high number of people imprisoned for drug offenses, HRW reported that temporary inmates also cause the enormous overcrowding and inhumane conditions in prison today.
"Overcrowding and understaffing make it impossible for prison authorities to maintain control within many facilities, leaving detainees vulnerable to violence and gang activity," says the report by HRW, which found that more than 622,000 adults are behind bars, 67 percent more than the prisons were built to hold, according to official data.
As for extrajudicial killings by police, the group criticized the lack of more severe punishment given to those agents who kill arbitrarily.
"When a police officer executes a criminal, a suspect to be a criminal, who knows that the police will kill or torture barbarically, he will not surrender peacefully and, at the earliest opportunity, will kill the police officer, whether on or off duty," HRW Brazil director, Maria Laura Canineu, was quoted as saying by Agencia Brasil.
Despite the criticisms, the human rights organization did acknowledge some advances made in the past few years in the country. Amongst the praised advances were the expansion of custody hearings programs to all state capitals and the Ministry of Justice's implementation and consolidation of the mechanism to combat torture.


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and special colorful tika's on the forehead.
Bhola and his brother Boldeb were honored by their sisters and vice versa
Then Sue and I each acquired 2 tika sisters (and Eli a brother).
As I proudly displayed my 'stoplight' Tika
In true Nepali style; what celebration would be complete without FOOD and LOTS of it!!
After the ceremony and food, we went visiting friends and enjoyed wonderful Chia and a short photoshoot.
What a wonderful celebration of life and how to live it; love and how to give it!


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Published at Wednesday, September 12th, 2018 - 17:33:55 PM. Beanbag. By Belinda Vargas.
The reclining chair was made up of a dozen pieces of polyurethane foam and was protected by different types of fur. Despite the fact that the bag was circular it would would mould by itself to the curves associated with the sitter, who could then nore easily obtain a comfortable seating position of different angles. Some debate that the Sea Urchin is very little more than an altered futon mattress, not really that it makes much difference because the Sea Urchin is typically credited as being the precursor to the 'Sacco' which is what most people realize these days as the modern beanbag.
Beanbag furniture has been around sense the '60s. They quickly became popular and have remained so today. There are plenty of reasons that beanbags are the best if you want comfort and convenience. They are easy to move, more comfortable then anything on the market, affordable, and can fit in event he tightest living spaces. It's no surprise that the beanbag is the prime choice for many people looking for a new place to sit. Beanbags are typically filled with PVC "beans" which give them their name. With all the small beans in the bag they are incredibly lightweight for their size, and can be moved with very little effort. On top of that, you are not limited by shape. Sense they are not made of pre-cut padding, you are able to adjust them and flex them into any space you desire.
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Welcome to Health Holistica
We have a passion to help people, which starts from the moment you walk into our treatment rooms.
We work in very calming, relaxing and peaceful surroundings with background sounds of subtle healing music. We listen with compassion and understanding to your inner most concerns or everyday aches and pains. We will help you find a "feel good factor" about yourself and guide you to maintain a healthier body and mind.
Health Holistica Treatments are a wonderful, relaxing and soothing experience, where the aromas from the essential oils will leave you feeling perfectly calm and relaxed. Our treatments will help reduce the tension in your body, help to improve your skins condition, improve circulation, plus help to eliminate toxins which build up in our body – so basically every massage is like a De-tox for your body.
Holistic and Complimentary Therapies are drug free, safe and suitable for almost anyone, whatever their age. Focusing on the whole person and not just the symptoms, holistic therapies aim to bring balance to the whole body. It will be our job to adapt a treatment for your needs.
You may suffer with acne, IBS, insomnia, PMT, back, neck and shoulder strain, hot flushes or stress, tinnitus or glue ear, these are just a few of the problems that our treatments can help with.
Even though we believe in conventional medicines, we find it focuses only on providing a quick fix to your symptoms, without addressing the underlying causes and ensuring your long-term health.
We don't claim to solve all health issues, however we do have an excellent track record with our existing clients! So whether you're not sure if we can help you, or unsure what treatment approach will work best for you, then please contact us at Health Holistica for a chat and we will do our very best to help. We always listen respectfully and give you essential guidance where needed.
It will cost you no more than 10 minutes of your time which could change your life!


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zondag 23 september 2012
CULTO DEL CARGO - st 7'' 2012 (italy)
D-beat from italy!
no slow boring crap,but with some great thrashy riffs and filthy vocals! just getting a bit into the whole d-beat stuff so what do i know??? but this is a pretty damn good record!!! go pick it up!
in december these guys will record a couple of new songs for an upcoming split with BRIVIDO from Croatia...
this was send in by the band,so thx for the tunes dudes!
you can download the mp3's from the links in the pics above or here (with corrected title for track #2 ;-0)
and lyrics in english and italian are included as PDF file,unfortunaly i couldn't open/read the english lyric sheet so no clue what their lyrics are about but pretty sure these ain't luv songs so....go figure out yourself!!!!
D.I.Y. or die!
and talking about D.I.Y.
think the band released this by themselves so that really cool!
d/l here:
or through here:
4 opmerkingen:
- Anoniem24 september 2012 om 06:33
there is a problem with the sendspace link. however the other link works.BeantwoordenVerwijderen
- Anoniem24 september 2012 om 10:16
not bad,not bad at all...Btw if you can post something by Unwise (japanese hardcore band) i would be glad :) im searchin for discography,its possible? thanksBeantwoordenVerwijderen
by Samia
fixed sendspace linkBeantwoordenVerwijderen
the only ones i have are the 1998-1999 7 inches and those came from the damagingnoise blog,only 7 tracks...
not sure if there's an official discography,but if there's ,i need to hear it!
ill keep an eye out,sorry
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text: The challenges of retrofitting New York City's multifamily housing stock against future climate threats, including the potential effect on the city's limited stock of affordable housing, are examined in a report by the New York University Furman Center, a MacArthur grantee. The report finds storm-proofing and retrofitting older buildings will be particularly challenging. New York's shortage of affordable housing may make the direct and indirect costs of retrofitting difficult to bear given that the majority of units in flood-prone areas are either rent-stabilized or receive a government subsidy to provide affordable housing.


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I believe in love.
Here is a brief post from The Scriptorium that takes a look at two possible readings of "God Part II," asking if the song's narrator is sincere or not in the final affirmation of belief in each stanza. Excerpt: Luther spoke of the dramatic tension of the Christian life as one in which believers are simul iustus et peccator —at once fully righteous and fully sinful. This makes no sense, but it sure does explain a lot. On this second reading, Bono's 'I' is sincere throughout, even if he is a hapless, sorry mystery to himself and us.
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Lindsay, Brian and Bogart in PEI
Posted by Rob & Lauren Lim on
Last fall (please don't laugh at how far behind I am here!) we went to Prince Edward Island for my cousin's wedding. PEI is such a gorgeous place, we just had to head out the day after the wedding to take some portraits of the newly married couple! We found an amazing little fisherman's wharf, and frolicked around at sunset. So today I'm going to share a few of my fav images from our time together!
Please note that Bogart, their adorable little pup, seriously knows how to pose.
Hope married life is treating you two well! Thanks again for the awesome evening, can't think of a better way to take in a perfect sunset on PEI. Well, chowing down on a lobster supper would come close. ;)
Lauren :)


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Cost Per Baptism
What if our church or ministry budget was evaluated by Cost Per (Believer) Baptism?
How many truly converted people have been added to the kingdom through our ministry in the past year?
Looking at our annual expenses, what is the cost per new believer?
It may be several thousand dollars. For many churches it may be $100,000 or more!
Is our ministry effective?
Is it efficient?
What can be changed to make it more effective?
Money is a measure of value. According to our budgets, what do we value?
Copyright © 2006 Ronald G. Hedberg. All rights reserved.


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- Research article
- Open Access
- Open Peer Review
MiR-181a contributes to bufalin-induced apoptosis in PC-3 prostate cancer cells
© Zhai et al.; licensee BioMed Central Ltd. 2013
- Received: 21 July 2013
- Accepted: 18 November 2013
- Published: 23 November 2013
Bufalin is a major active compound of cinobufacini, which comes from dried toad venom and has been used for treatments of various cancers in China for many years. A number of studies have demonstrated that bufalin can induce apoptosis in some cancers. However, effects and mechanism of bufalin on prostate cancer cells remain unknown.
Apoptosis assay was measured by the annexin-V/PI flow cytometric assay. Western blot was used to measure Caspase-3 and Bcl-2. qRT-PCR was used to measure the relative expression of miR-181a.
Bufalin was found to induce the expression of miR-181a, a small non-coding RNA believed to induce apoptosis by repressing its target gene, BCL-2. In prostate cancer PC-3cell line, bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor, which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation.
Our dataindicatedthat miR-181a mediates bufalin-induced apoptosis in PC-3 cells. Thus, we presented here a new pharmacological mechanism for bufalin in anti-tumor therapy.
- miR-181a
- Bufalin
- Apoptosis
- Prostate cancer
- Traditional Chinese medicine
Cinobufacini is extracted from the skins and parotid venom glands of the toad Bufo bufo gargarizans cantor and has been widely used in clinical therapy for various cancers in China. The major pharmacologic constituents of cinobufacini are bufadienolides (which primarily include bufalin, cinobufagin, resibufogenin, bufotalin and lumichrome), alkaloids, biogenic amines, peptides and proteins [1]. Studies have suggested that some of its active compounds (e.g., bufalin and cinobufagin) exhibit significant antitumor activity, including inhibition of cell proliferation, induction of cell differentiation, induction of apoptosis, disruption of the cell cycle, inhibition of cancer angiogenesis, reversal of multi-drug resistance, and regulation of the immune response [2]. The mechanism of bufalin-induced apoptosis has been well investigated in various cancer cells. For example, bufalin was shown to induce apoptosis of human gastric cancer cells by inhibiting the PI3K/Akt signaling pathway [3]. In prostate cancer cells, bufalin significantly induces apoptosis through the p53- and Fas-mediated apoptotic pathways [4]. Bufalin was shown to induce ROS-mediated Bax translocation, mitochondrial permeability transition, and caspase-3 activation in human lung adenocarcinoma cells [5]. In an orthotopic transplantation tumor model of human hepatocellular carcinoma, bufalin showed significant anticancer action by regulating expression of apoptosis-related proteins, Bcl-2 and Bax [6]. Similarly, Takai et al. showed that bufalin-induced apoptosis was associated with levels of Bcl-2, Bcl-XL and caspase-9 in human endometrial and ovarian cancer cells [7].
MicroRNAs (miRNAs) are small, endogenous non-coding RNA molecules of ~ 22 nucleotides (nt) in length that can regulate gene expression. MiRNAs recognize and repress target mRNAs based on sequence complementarity, and are critical in regulating a variety of biological processes, including cell cycle, differentiation, development, and metabolism, as well as such diseases as diabetes, immuno- or neurodegenerative disorders, and cancer [8]. In cancer, miRNAs function as regulatory molecules, acting as oncogenes or tumor suppressors. Dysregulation of these miRNAs contributes to tumorigenesis by stimulating proliferation, angiogenesis and invasion [9–11].
MiR-181 was first identified in promoting B-cell differentiation when expressed in hematopoietic stem/progenitor cells [12]. Subsequently, the miR-181 family (miR-181a and miR-181b) was shown to function as tumor suppressors that triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells [13]. Ouyang et al. showed miR-181 to induce apoptosis by targeting multiple Bcl-2 family members in astrocytes [14]. Recently, several studies further showed that by targeting various multiple anti-apoptosisgenes, such as BCL-2, miR-181 significantly enhances drug- or radiation-induced apoptosis in various cancer cells [15–20]. In chronic myeloid leukemia (CML), the RalA gene was reported as a direct target of miR-181a, and is associated with cell proliferation, G2-phase arrest and apoptosis [21].
Here, we report that bufalin treatment could induce miR-181a expression. We also show that miR-181a contributes to bufalin-induced apoptosis in prostate cancer cells. Thus, our study illustrated a new pharmacological mechanism for bufalin in anti-tumor therapy.
Cell culture and treatment
Human prostate carcinoma PC-3 cells were maintained in Ham's F-12 medium (Invitrogen, Carlsbad, CA, USA) supplemented with 10% fetal bovine serum (Invitrogen, Carlsbad, CA, USA). Bufalin (Sigma-Aldrich, St. Louis, MO, USA) was dissolved in DMSO and stocked in 1 mM solution. Cells with 80–90% confluence in 12-well plates were treated with indicated concentrations of bufalinfor 24 hours. When combined with miR-181a inhibitor, 50 or 100 μM of miR-181a inhibitor was transfectedinto cells (~70% confluence in 12-well plates) 12 hours before bufalin treatment. MiR-181a, miR-NC and their inhibitors were purchased from GenePharma (GenePharma, Shanghai, China). Sequence of miR-NC was from C. elegans and has no known similar sequence in the human genome. Transfection was performed using Lipofectamine™ RNAiMAX (Invitrogen, Carlsbad, CA, USA).
RNA isolation and quantitative real-time PCR
Total RNA was isolated by Trizolreagent (Invitrogen, Carlsbad, CA, USA) according to the user's guide specifically for short RNAs. Briefly, cells were homogenized by RNApro reagent. After phase separation by chloroform, 2.5 volume of alcohol was added to the aqueous phase to precipitate total RNA containing short RNA. Total RNA was then recovered by centrifuge and dissolved in nuclease-free water. Two micrograms of total RNA was tailed and reverse transcribed by NCode™ EXPRESS SYBR® GreenER™ miRNA qRT-PCR Kit (Invitrogen, Carlsbad, CA, USA) according to the user's manual. Quantitative real-time PCR was performed by miRNA specific primers (Additional file 1: Table S1). All Ct values of miRNAs were normalized to 18S rRNA. The 2−ΔΔCt method was used to calculate relative expression level of miRNAs.
Apoptosis assay
The apoptosis assay was performed with an annexin-V-FITC apoptosis detection kit (Sigma-Aldrich, St. Louis, MO, USA) according to the user's manual. Cells after different time treatments were washed by twice with PBS (Phosphate Buffered Saline) buffer. Cells were then resuspended in 1 × binding buffer at a concentration of ~1 × 106 cells/ml, and 5 μl of Annexin V FITC conjugate and 10 μl of propidium iodide (PI) solution were added to each 500-μl cell suspension. Cells were stained by Annexin-V-FITC/PI for 10 min at room temperature. Stained samples were analyzed using MoFlo XDP flow cytometer (Beckman Coulter, Brea, CA, USA) and the apoptosis rate was determined using Flowjo software (Tree Star, Ashland, OR, USA).
Western blotting
Cells were washed with PBS and lysed in RIPA buffer. Cell lysate aliquots (10 μg) were separated on a 10% SDS-PAGE gel and transferred to PVDF membrane. Primary antibodies for Bcl-2, Caspase-3, RalA and β-actin were purchased from Abcam (Abcam, Cambridge, MA, USA). Secondary antibody coupled with HRP was from Sigma (Sigma-Aldrich, St. Louis, MO, USA). Membrane was visualized by ECL PicoLightChemiluminescence kit (Promoton, Shanghai, China). Membrane was then exposed to X-ray film in dark room.
Caspase-3 activity assay
Caspase-3 activity assay was performed by Caspase-Glo® 3/7 Assay kit (Promega, Madison, WI, USA) in 96-well plate according to the user's manual. Luminescence was measured on a Mithras Multimode Microplate Reader LB 940 (Berthold, Calmbacher, Germany).
Bufalin induced the expression of miR-181a
MiR-181a inhibitor attenuated bufalin-induced apoptosis
MiR-181a inhibitor can reverse bufalin-induced Bcl-2 decrease
MiR-181a inhibitor can reduce bufalin-induced caspase-3 activity
Cinobufacini, is a form of traditional Chinese medicine, and has been approved by the Chinese State Food and Drug Administration (SFDA) for many years. Cinobufacini injection is widely used in China to treat patients with various cancers [27]. Many clinical trials have shown it to effectively shrink lesions and improve patients' survival rate and quality of life. Bufalin, as a major active compound of cinobufacini, was considered to have great effect on tumors, including inhibition of proliferation and cancer angiogenesis, induction of differentiation and apoptosis, disruption of cell cycle, reversal of multi-drug resistance, and regulation of immune response [6]. Although various studies present the mechanism by which bufalin induces apoptosis in cancer cells, the anti-tumor activity of bufalin and miRNAs in inducing miR-181a expression had not been shown before this study.
Many miRNAs regulate various processes in tumorigenesis, including apoptosis and metastasis, and have received increasing attention in cancer research. To test if miRNA pathways crosstalk with the pharmacologic action of bufalin in cancers, we screened expression of some cancer-related miRNAs in PC-3 cells after bufalin treatment, and observed miR-181a expression to significantly increase in a dose-dependent manner. We also showed miR-181 to induce significant apoptosis through down-regulation of Bcl-2 protein. Furthermore, miR-181a inhibitor largely attenuated bufalin-induced apoptosis. Our results indicate that miR-181a mediates a downstream, bufalin-induced apoptosis pathway, and suggest a more detailed model for bufalin-induced apoptosis in which bufalin induces expression of miR-181a, which in turn inhibits Bcl-2 protein, resulting in apoptosis.
Based on our result, we presented here a more detailed model for bufalin-induced apoptosis. Bufalin treatment induced the expression of miR-181a, which in turn inhibited Bcl-2 protein and resulted in cell apoptosis.
This work was supported by Shanghai Municipal Health Bureau (ZYSNXD – CC - ZDYJ032).
Authors' Affiliations
- Yang LH, Jin XQ, Zhang WD: Studies on the chemical constituents from the skin of Bufo bufo gargarizans cantor. Journal of Shenyang Pharmaceutical University. 2000, 17: 292-295.Google Scholar
- Qi FH, Li AY, Inagaki Y, Kokudo N, Tamura S, Nakata M, Tang W: Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor. Int Immunopharmacol. 2010, 11: 342-349.View ArticlePubMedGoogle Scholar
- Li D, Qu X, Hou K, Zhang Y, Dong Q, Teng Y, Zhang J, Liu Y: PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells. Anticancer Drugs. 2009, 20: 59-64. 10.1097/CAD.0b013e3283160fd6.View ArticlePubMedGoogle Scholar
- Yu CH, Kan SF, Pu HF, Jea Chien E, Wang PS: Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells. Cancer Sci. 2008, 99: 2467-2476. 10.1111/j.1349-7006.2008.00966.x.View ArticlePubMedGoogle Scholar
- Sun L, Chen T, Wang X, Chen Y, Wei X: Bufalin induces reactive oxygen species dependent bax translocation and apoptosis in ASTC-a-1 Cells. Evid Based Complement Alternat Med. 2011, 2011: 249090-View ArticlePubMedPubMed CentralGoogle Scholar
- Han KQ, Huang G, Gu W, Su YH, Huang XQ, Ling CQ: Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol. 2007, 13: 3374-3379.View ArticlePubMedPubMed CentralGoogle Scholar
- Takai N, Ueda T, Nishida M, Nasu K, Narahara H: Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells. Int J Mol Med. 2008, 21: 637-643.PubMedGoogle Scholar
- Mo YY: MicroRNA regulatory networks and human disease. Cell Mol Life Sci. 2012, 69: 3529-3531. 10.1007/s00018-012-1123-1.View ArticlePubMedPubMed CentralGoogle Scholar
- Garzon R, Calin GA, Croce CM: MicroRNAs in Cancer. Annu Rev Med. 2009, 60: 167-179. 10.1146/annurev.med.59.053006.104707.View ArticlePubMedGoogle Scholar
- Li MF, Li J, Ding XF, He M, Cheng SY: microRNA and cancer. AAPS J. 2010, 12: 309-317. 10.1208/s12248-010-9194-0.View ArticlePubMedPubMed CentralGoogle Scholar
- Ruan K, Fang XG, Ouyang GL: MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett. 2009, 285: 116-126. 10.1016/j.canlet.2009.04.031.View ArticlePubMedGoogle Scholar
- Chen CZ, Li L, Lodish HF, Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004, 303: 83-86. 10.1126/science.1091903.View ArticlePubMedGoogle Scholar
- Shi L, Cheng ZH, Zhang JX, Li R, Zhao P, Fu Z, You YP: hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res. 2008, 1236: 185-193.View ArticlePubMedGoogle Scholar
- Ouyang YB, Lu Y, Yue S, Giffard RG: miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion. 2011, 12: 213-219.View ArticlePubMedPubMed CentralGoogle Scholar
- Bai H, Cao Z, Deng C, Zhou L, Wang C: miR-181a sensitizes resistant leukaemia HL-60/Ara-C cells to Ara-C by inducing apoptosis. J Cancer Res Clin Oncol. 2012, 138: 595-602. 10.1007/s00432-011-1137-3.View ArticlePubMedGoogle Scholar
- Chen G, Zhu W, Shi DZ, Lv L, Zhang C, Liu P, Hu WX: MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol Rep. 2010, 23: 997-1003.PubMedGoogle Scholar
- Galluzzi L, Morselli E, Vitale I, Kepp O, Senovilla L, Criollo A, Servant N, Paccard C, Hupe P, Robert T: miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res. 2010, 70: 1793-1803. 10.1158/0008-5472.CAN-09-3112.View ArticlePubMedGoogle Scholar
- Li H, Hui LL, Xu WL: miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2. Acta Biochim Biophys Sin (Shanghai). 2012, 44: 269-277. 10.1093/abbs/gmr128.View ArticleGoogle Scholar
- Zhu DX, Zhu W, Fang C, Fan L, Zou ZJ, Wang YH, Liu P, Hong M, Miao KR, Xu W, Li JY: miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. Carcinogenesis. 2012, 33: 1294-1301. 10.1093/carcin/bgs179.View ArticlePubMedGoogle Scholar
- Zhu W, Shan X, Wang TS, Shu YQ, Liu P: miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. Int J Cancer. 2010, 127: 2520-2529. 10.1002/ijc.25260.View ArticlePubMedGoogle Scholar
- Fei J, Li Y, Zhu X, Luo X: miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). PLoS One. 2012, 7: e32834-10.1371/journal.pone.0032834.View ArticlePubMedPubMed CentralGoogle Scholar
- Cho WC: MicroRNAs in cancer - from research to therapy. Biochim Biophys Acta. 1805, 2009: 209-217.Google Scholar
- Masuda Y, Kawazoe N, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K: Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells. Leuk Res. 1995, 19: 549-556. 10.1016/0145-2126(95)00031-I.View ArticlePubMedGoogle Scholar
- Watabe M, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K: The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. J Biol Chem. 1996, 271: 14067-14072. 10.1074/jbc.271.24.14067.View ArticlePubMedGoogle Scholar
- Watabe M, Ito K, Masuda Y, Nakajo S, Nakaya K: Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. Oncogene. 1998, 16: 779-787. 10.1038/sj.onc.1201592.View ArticlePubMedGoogle Scholar
- Watabe M, Kawazoe N, Masuda Y, Nakajo S, Nakaya K: Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells. Cancer Res. 1997, 57: 3097-3100.PubMedGoogle Scholar
- Zhai XF, Chen Z, Li B, Shen F, Fan J, Zhou WP, Yang YK, Xu J, Qin X, Li LQ, Ling CQ: Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial. J Integr Med. 2013, 2: 90-100.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/325/prepub
Pre-publication history
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Wide Leg Capri Jeans In Plus Size
Style #: WFOZCP2604
Original Price$89.00
Wide Leg Capri Jeans In Plus Size is rated out of 5 by 2.
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Additional Information
This silhouette is trending in a major way, and it's easy to see why it's so popular. NYDJ's Wide-Leg Capri Women's Jeans in Plus Size With Clean Hem are the undeniably cool, easy-to-pull-off style you have to have this season. Like all NYDJ denim, these Women's Jeans feature our signature Lift Tuck® Technology, which flattens the front, using a proprietary slimming panel with a patented criss-cross design. Features classic five-pocket styling, zip fly and button closure.
Fabric & Materials
- Lift Tuck® Technology uses a patented criss-cross panel to flatten in the front, while curve-contouring construction flatters your back side
- 73% Cotton 15% Lyocell 9% Viscose 3% Lycra Elastane
- Imported
- Zip fly and button closure; 5-pocket style
- Machine was cold, line dry
Fit & Sizing
- Inseam: 23"
- High Rise: 11.5" (front)
- Wide Leg Opening: 16.25"
- Measurements taken on size 16W
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Wide Leg Capri Jeans In Plus Size is rated out of 5 by 2.
Rated 2 out of 5 by Beth S from Lovely color; Fit was off The material (in the rose color) is a heavy denim and the sizing was off--far too large. I ordered according to my measurements and a size down, but that didn't work with these pants. I typically do wear a size smaller in NYDJ. The denim also makes these pants impractical for summer where I live--New Mexico. Returned these.
Date published: 2019-03-04
Rated 5 out of 5 by Fluffy from Lovely White Jeans Perfect pants for summer, white always looks so chic. These are perfect width leg and length. Love them. Please make them in more colors.
Date published: 2019-04-02
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St. Peregrinus
Author and Publisher - Catholic Online
Also known as Cetheus, he was bishop of Amitemum. He was murdered by the Lombards by being drowned in the Aterno River after pleading for mercy for a prisoner condemned to death.
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Colette was the daughter of a carpenter named DeBoilet at Corby Abbey in Picardy, France. She was born on January 13, christened Nicolette, and called Colette. Orphaned at seventeen, she distributed her inheritance to the poor. She became a Franciscan tertiary, and ... continue reading
Sts. Cosmas & Damian
Sts. Cosmas and Damian were brothers, born in Arabia, who had become eminent for their skill in the science of medicine. Being Christians, they were filled with the spirit of charity and never took money for their services. At Egaea in Cilicia, where they lived, they ... continue reading
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Christian Saints & Heroes
Feast of the Deacon St Vincent Calls the Church and her Deacons to Heroic Virtue
By Deacon Keith Fournier
Vincent was a man like us who encountered the same Risen Lord Jesus whom we have encountered. He struggled with the choices which always accompany living the Christian life in the midst of a culture which has squeezed God and His truth out of the center of its ... continue readingMore Christian Saints & Heroes