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LeBron James is in Mount Rushmore company now, earning comparisons to basketballs legends.
Just two years ago the King was mocked as pretender to the throne. He was an overhyped loser. When crunch time came, he was crunched.
Therefore, part of the pleasure and privilege of watching James take command of Game 7 of the NBA Finals was comprehending his transformation as a player but more so as a competitor.
The difference between the James of 2011, who was consumed by self-doubt as much as he was by the Dallas Mavericks, and the James of 2013, who hauled a flawed Miami Heat team to a second consecutive championship, was one of mind over muscle.
The growth of LeBron James has been as riveting to observe as any of his rim-melting dunks, sixth-sense passes or gravity-defying blocks.
As he rode atop a red double-decker bus down Biscayne Boulevard during the Heats victory parade Monday, he wore a T-shirt imprinted with the Nike campaign buzzword Witness. It no longer seemed pompous and stupid. Turns out it was prophetic. Because thats what Miami fans get to do up close witness the maturation of an athlete who was psychoanalyzed like no other.
Some of his predecessors in sports have faced greater scrutiny, pressure and malice. When James spoke of the haters who ridiculed and jeered his decision to leave Cleveland in 2010 and ally with the Big 3 in Miami, it seemed minuscule compared to the hate Jackie Robinson endured because of his decision to break the color line in baseball.
Heavy burden
But resentment weighed James down. He miscalculated the acidic backlash, which ate away at his confidence. It took him a long time to admit it, but it was apparent against Dallas in the 2011 Finals, when the Heat lost Game 6 at home. Everyone waited for James to pounce. Instead, he hesitated, deferred, dribbled as if he was circumnavigating an island. It was agonizing.
Flash forward to the celebration inside AmericanAirlines Arena on Monday, when James shimmied his hips and led fans in a singsong chant of I aint got no worries. He looked so happy and weightless.
Flash to Game 7 against San Antonio, which the Heat had to win over the demoralized Spurs lest the Big 3 blueprint be ripped apart as an ostentatious failure. The team goes through each season with the everything-to-lose expectation of championship or bust, which feels like a 60-pound boulder on your back, team president Pat Riley said.
But each time the Spurs thrust, James parried. They tied the score in the third quarter, he responded with a three-pointer. They went ahead by one, James nailed two three-pointers in a row. In the fourth quarter, the Spurs, with their dynasty on the line, cut the gap to four points. James sank a 17-foot jump shot. A minute later, another pullup. In the final 30 seconds, after Tim Duncan missed the hook and tip that he said will haunt him forever, James delivered the coup de grace a 19-footer, followed by a steal and two free throws.
He finished with 37 points and 12 rebounds. Most remarkably, he took the Spurs bait and swam away. He took what the lane-packed defense dared him to take, jump shots in lieu of power drives to the basket. In Game 7, he made five three-pointers and scored all seven of his second-half field goals from outside the paint.
He made enough shots to make us change our defense over and over again, Duncan said. We just couldnt find a way to stop him.
James studied Games 1 and 2, when he was limited to an average of 17.5 points. Had this been 2011, he would have second-guessed himself, overreacted to the whats wrong with LeBron? criticism and made things worse. But in 2013, he calmly re-calibrated. He went to his mid- and long-range jumper, not exactly supple but reliable after an assiduous summer of refinement. He trusted himself.
Likewise in Game 6 when James turnovers down the stretch nearly cost the Heat everything before Ray Allen rescued the season and the grand plan and the Big3 and maybe Erik Spoelstras job with his three-pointer that sent the game into overtime. James never panicked not even when his headband came off. In overtime his defensive fury overwhelmed the Spurs. In Games 6 and 7, he averaged 34.5 points.
Little desperate
Yes, there was luck, James acknowledged.
There was a miracle in Game 6, Riley said of the Heats rally from five points down in the last 28 seconds. Thats the bullet we dodged. I was a little bit desperate.
But, of course, the Heat also made its own luck by obtaining Allen and holding onto Shane Battier. Signing Chris Birdman Andersen, a gamble given his August knee surgery. Staying healthy despite a marathon season that began in China, or, for James, in London. Wade got injured but not devastatingly so, like Derrick Rose, Danny Granger, Rajon Rondo, Russell Westbrook or Kobe Bryant. And there was the luck James built, extra shooting practice by extra shooting practice.
One by one, the Heat players struggled through 14 games against Indiana and San Antonio. Battier got stuck in a 2-for-15 slump. Mario Chalmers did his disappearing act. Wade played erratically on his bruised right knee. Chris Bosh had massive matchup problems against Roy Hibbert and Duncan. The weaknesses of the Big 3 and positionless basketball were often exploited. But James rose to the challenge slowly, inexorably.
He publicly promised to play better, and he did. He pledged to lead, and he did. The younger LeBron, so eager to please and scared to disappoint, would have been frazzled to pieces by the Spurs guile and grit, and by the rush to bury Miamis Big 3 and all they represented as wrong with modern-day disloyalty.
James, 28, validated his decision with the repeat. He flipped all the negativity on its head. One title would not have been good enough. But back-to-back was special; Miami became only the sixth franchise in NBA history to win consecutive championships.
When James accepted the Finals MVP Trophy from Bill Russell, he joined Russell and Michael Jordan as the only players in NBA history to win back-to-back season MVP and Finals MVP honors.
Im LeBron James from Akron, Ohio, from the inner city, he said as confetti rained down. Im not even supposed to be here. Every night I walk into the locker room, I see a No. 6, James on the back, Im blessed. What everybody says about me off the court dont matter. I aint got no worries.
In that moment, the villain was gone if he was ever really there in the first place. Plenty of people still despise James, but they despise the notion more than the man. He freed himself from the anger when he apologized for the way he left Cleveland.
Do you ever hear him complain (except to officials)? Do you ever hear him displace blame on others, such as Spoelstra or underperforming teammates? Do you ever hear of a rift in Heat camaraderie? Do you ever hear of misbehavior or typical superstar rudeness? Do you know how magnanimous a personality it takes to bring Miamis diverse populace together, extinguish our notorious hostility and gladly lift the city on his shoulders?
Time to celebrate
In the aftermath of Game 7, James squirted champagne in the locker room (one guy was smart enough to put on ski goggles) and strode the arena corridors with a cigar clamped between his teeth. He earned that joy, not merely via 6-8, 260 pounds worth of freakish talent but through dogged dedication to improve his game even though he has been told since age 12 that he is the No. 1 player on the planet.
This is a guy who unabashedly loves his mother and in postgame comments spoke excitedly about his upcoming wedding to his longtime girlfriend. He said that to come through for my teammates makes me more satisfied than anything in the world.
Success makes it easier to see how James was misunderstood. Success makes it easier for James to see his true self.
I want to be, if not the greatest, one of the greatest to ever play this game, he said after Miamis victory. I will continue to work for that, and continue to put on this uniform and be the best I can be every night.
During the sun-soaked celebration Monday, as players waved to spectators or, in Birdmans case, flapped and held the gold trophy aloft, James wore a tropical-colored hat with a sparkly gold Nike crown logo stuck on the front. It looked like it was cut from the sort of plastic toy you would buy for a costume party. He was downplaying the whole king thing, having fun with it. His reign should be enjoyed. Finally for King James, easy lies the head that wears the crown.


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Friday, August 27, 2010
Castle living..
11 comments:
- Wendy said...
If the castle was in France or Italy off the shore of the ocean...then yes. Just a castle? Not for me. Location, location, location.
- August 27, 2010 at 5:47 AM
- a Broad said...
Yes, as Wendy said .. not just anywhere but yes !
- August 27, 2010 at 6:23 AM
- Splendid Sass said...
Such beautiful images. The 3rd is my favorite. Have a great weekend.
- August 27, 2010 at 6:41 AM
- Aoife.Troxel said...
And if I couldn't have the castle, I could settle for a converted cathedral or church.
- August 27, 2010 at 6:54 AM
- Acquired Objects said...
Such a hardship but yes I think I could with stand living there!...lol. Such a beautiful place.
Have a wonderful weekend!
- August 27, 2010 at 8:47 AM
- priscilla said...
I have just had a walk around Göttingen, and saw a candelabra exactly like this in a shop window and loved it. Got home, sat down to check my favourite blog, and here it is again (first few pics) - is it a sign I should buy it??
- August 27, 2010 at 9:16 AM
I think that particular castle would be just fine ... and so is the current resident "king" of said castle ... have seen the pics! I so love your blog ... thanks!
- August 27, 2010 at 9:34 AM
- Terri said...
Oh yes, I could live in a castle like this. Stunning!
- August 27, 2010 at 4:52 PM
- design traveller said...
Majestic! A place with amazing atmosphere...
- August 28, 2010 at 1:53 AM
- la habitación de Pandora said...
Me encantaria vivir en un castillo. Hermosas imágenes!!
- August 28, 2010 at 3:55 AM
- Beadboard UpCountry said...
I don't think I would live in ANY castle, but sure wouldn't mind these digs!!!!!Maryannexo
- August 28, 2010 at 12:27 PM

subset: commoncrawl


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Red wines that are more fruit-forward and lighter in tannin and body.
Medium bodied reds that go down easy, with smooth tannins and supple fruit.
Wines where earthy and/or spicy dominate the flavors – typically medium to full body.
Full bodied wines that have concentrated fruit and are higher in alcohol and/or tannins. Some need age.
Rosso di Montalcino, made with 100% Sangiovese, is deep ruby red with purple reflections. It displays fresh, intense aromas of ripe fruit infused with spice from the oak. It is full-bodied and fruit forward, structured by supple tannins.
Best when served slightly cooler than room temperature. Well-matched with veal, pork and poultry dishes, as well as duck and goose.
"Fruit and floral flavors are at the forefront of this charming, supple red. Firms up on the finish, where cherry and tobacco notes mingle. Best from 2014 through 2020."
90 Points
Wine Spectator
"A wine with ripe strawberries and cherries with hints of cocoa. Full and chewy. Structured and stylish for a Rosso. Delicious now with lots of tension but better in 2013."
90 Points
James Suckling
Col d'Orcia is the internationally celebrated producer of one of Italy's most revered red wines, Brunello di Montalcino. Situated on the outskirts of the medieval hilltop village of Montalcino in Tuscany's Siena province, the estate has a rich winemaking history that dates back to the 1700's. In the hands of the Cinzano family since 1973, Col d'Orcia is owned today by Count...Read More About Col d'Orcia
One of the most important wine regions in Italy, Tuscany is home to the cities of Florence and Siena, the districts of Chianti and Brunello di Montalcino, and the wineries of Sassicaia, Tignanello and Ornellaia. Tuscany is also home to the indigenous Italian grape variety, Sangiovese. Most of the wine coming from Tuscany is made from some clone of this...Read More About Tuscany
Sangiovese (SAHN-gee-oh-VAY-zee) Blood of Jove (literally translated) The principal grape of Chianti - in fact, the principle grape of all of Tuscany - has had its ups and downs. For a stint in the 70s and 80s, wines labeled Chianti contained cheap red wine packaged in a straw casked bottle, most popular for the candle holder it would become. But no more. Sangiovese re...Read More About Sangiovese
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The Small Business Ombudsman works with small businesses to ensure they receive timely answers to questions and timely resolution of issues involving state government. The Ombudsman also works with the small business community to identify problems in state government related to unnecessary delays, inconsistencies between regulatory agencies, and inefficient uses of state resources. This position was established by the 2004 session of the NC General Assembly in paragraph 143-B-432.1 of Section 13.9A.(e) of Article 10 of the General Statutes.
Additional activities of the Ombudsman are to:
Please contact the Ombudsman with small business questions or concerns toll-free at 1-800-228-8443.
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Last quarter moon occurs at 12:54 a.m.
After sunset, aim binoculars/cameras to brilliant Venus, Evening Star, in the northwest. The Beehive star cluster shimmers 3 degrees upper left of Venus. The Gemini Twins, Castor and Pollux, hug the northwestern horizon and set early. Leo, Lion, crawls lower in the west.
Corvus, Crow, flies ahead of Spica and silver Saturn in Virgo in the southwest. The stars of Libra follow Saturn. Huge Scorpius clears the southeastern horizon. Ruddy Antares, the red heart, beats in the Scorpion's torso. The Sagittarian Teapot (center of our galaxy) closely follows Scorpius. Capricornus, Sea Goat, appears on the southeastern horizon.
Hercules leads Vega, in Lyra the Harp, and the vast Summer Triangle higher in the northeast. Arcturus, Herdsman, sparkles overhead. Corona Borealis, Northern Crown, follows Arcturus. The Big Dipper edges into the northwest. Its bowl faces Polaris, North Star. The tip of the Little Dipper's handle is Polaris. Late evening, dim blue Neptune rises in the southeast in Aquarius. Pegasus, Winged Horse, appears in the east.
By 6 a.m. the waning moon rises to the right of the Seven Sisters (Pleiades star cluster) in the east.
Before 6 a.m., the crescent moon floats between two star clusters in the east: Seven Sisters (top) and the V-shaped Hyades (below). In binoculars, compare the red tones of Aldebaran in the Hyades to ruddy Mars lower left of Aldebaran. Bright Capella leads Auriga, Charioteer, higher in the northeast. The Royal Family arrives in the northeast.
Blue-green Uranus drifts across the southeast in Pisces, Fish. Vega leads the Summer Triangle westward. Cygnus, Swan, soars within the Triangle. The tilted Sagittarian Teapot "pours" onto the stinger tail of the Scorpion in the southwest. The Summer Milky Way arches from the Teapot to the Triangle.
At 11 a.m. Earth is farthest from the sun that it will get this year, 94.5 million miles.
At dawn aim binoculars to the old moon rising to the lower right of Mars in the east. Bright Jupiter appears 7 degrees below Mars.
Compiled by Barb Yager, Southern Cross Astronomical Society, 305-661-1375, scas.org


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President's Circle
The New England College of Optometry invites you to join the President's Circle,a prominent group of individuals whose generosity enables the College and New England Eye to educate optometrists and improve the visual health of children, elders and underserved populations. Members of the President's Circle give a minimum of $1,000 per year between July 1 and June 30 ($500 for alumni in their first decade). Benefits of this and our other giving societies include recognition in College publications and exclusive invitations to events. President's Circle members inspire the entire NECO community and enhance the quality of life for our students and patients.
The Foster Namias Society
The Foster Namias Society honors individuals who have remembered the New England College of Optometry and the New England Eye in their estate plans. We recognize this esteemed group of individuals with deep gratitude for their commitment to the success of tomorrow's optometrists and patients. Members of the Foster Namias Society enjoy a special relationship with the College's leadership, including exclusive invitations to events hosted by the president, informational updates and recognition in publications. For more information on the benefits of becoming a Foster Namias Society member, click here.
The Philanthropist's Society
The New England College of Optometry is proud to honor a distinguished group of contributors whose cumulative giving demonstrates their exceptional commitment to the College and New England Eye. Their dedication enables the College to prepare the next generation of eye care providers, teachers and innovators. Members of the Philanthropist's Society are recognized for cumulative giving of $50,000 and more. Members of the society enjoy a special relationship with the College's leadership, including exclusive invitations to events hosted by the president and the Board of Trustees, as well as recognition in College publications.


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Say hello to your new spring-summer staple - the skater dress! The skater shape has been refreshed for SS14 with texture, colours and prints that tick all the trend boxes. The feminine dress works just as well by night as it does for the day, just add statement accessories and heels and you're good to go!
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Women's skater dresses are an essential style for the new season. Get in on the trend with must-have styles from River Island including dresses in an array of colours and prints. Shop the full range of River Island women's skater dresses online.


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Map It
Map City Services
LouisvilleKY.gov Links
Wednesday July 23, 2008
The LMPD's Sixth Division will be hosting an open house for its new location.When: Thursday, July 24, 2008 from 3 pm to 6 pmWhere: 5600 Shepherdsville RoadThe Sixth Division is moving its headquarters to 5600 Shepherdsville Road and will be hosting an open house for the community. The media are invited to attend. Directions: The new headquarters is located in the Park Jefferson Industrial Park. Take entrance #2 and the new Sixth Division is the second building on the right.


text: Bulk Fuel Communications Water Distribution, Source and Treatment Systems City of Hoonah Public Water System ID# AK2130067 Primary Source Surface Water System Type Community Water System Population Served 980 Water System Details URL http://dec.alaska.gov:8080/DWW/JSP/WaterSystemDetail.jsp?tinwsys_is_number=4287&tinwsys_st_code=AK&wsnumber=AK2130067 Sewage Collection Systems Hoonah Wastewater Collection System Number of Lift Stations 5 Service Connections 300 Residents 760 Wastewater Collection URL https://myalaska.state.ak.us/dec/water/opcert/Home.aspx?p=SystemSearchRecord&d=279 Hoonah Wastewater Treatment System Class 1 Gallons Per Day, Capacity 100,001 - 500,000 Wastewater Treatment URL https://myalaska.state.ak.us/dec/water/opcert/Home.aspx?p=SystemSearchRecord&d=278 Refuse/Landfill Systems City of Hoonah DEC Landfill Permit # SW3A059-17 Landfill Name Hoonah Landfill DEC Landfill Classification Class III DEC Landfill Permit Status Current DEC Landfill Expiration Date 9/21/2017 DEC Landfill URL http://dec.alaska.gov/Applications/EH/SWIMS/ModFacility.aspx?siteId=2 Electric Utility Inside Passage Electric Cooperative Power Source Diesel generator PCE Eligible Yes Residential Rate $0.63 per kWh, June 2012 PCE reimbursement rate $0.42 per kWh, June 2012 Residential Rate after PCE $0.21 per kWh, June 2012 Note Wind Turbines installed Rated Wind Capacity Kilowatts ISER Community Data Summary https://akenergygateway.alaska.edu/community-data-summary/1403488/ Health Care Visitor Accommodations/Information Local Facilities and Utilities Transportation Facilities Hoonah Airport Airport Type Airport Airport Code HNH Airport Owner State of Alaska -DOT&PF Southeast Region Airport Use Public Airport Ownership Public FAA URL http://nfdc.faa.gov/nfdcApps/airportLookup/airportDisplay.jsp?category=nasr&airportId=HNH Runway-1 ID '06/24 Runway-1 Size 3,367 ft. x 75 ft. Runway Materials/Condition Asphalt-Good Condition Runway-2 Size Hoonah Seaplane Base Airport Type Seaplane Base Airport Code OOH Airport Owner State of Alaska -DOT&PF Southeast Region Airport Use Public Airport Ownership Public FAA URL http://nfdc.faa.gov/nfdcApps/airportLookup/airportDisplay.jsp?category=nasr&airportId=OOH Runway-1 ID 'E/W Runway-1 Size 9,000 ft. x 5,000 ft. Runway Materials/Condition Water Runway-2 Size Public Safety Entities Hoonah Police Department City Police Station Yes Hoonah Volunteer Fire Department Emergency Medical Services Yes Structural Firefighting Yes Marine Firefighting Yes Airport Fire/Rescue No Industrial Firefighting No Airlines Air Excursions LLC Enplaned Passengers 227 passengers in 2013 Enplaned Freight 9,507 lbs. in 2013 Enplaned Mail 22,886 lbs. in 2013 Alaska Central Express Enplaned Passengers 0 passengers in 2013 Enplaned Freight 184 lbs. in 2013 Enplaned Mail 685 lbs. in 2013 Alaska Seaplane Service Enplaned Passengers 1,644 passengers in 2013 Enplaned Freight 54,308 lbs. in 2013 Enplaned Mail 46,125 lbs. in 2013 Scott Air LLC dba Island Air Express Enplaned Passengers 9 passengers in 2013 Enplaned Freight 0 lbs. in 2013 Enplaned Mail 0 lbs. in 2013 SeaPort Airlines, Inc. d/b/a Wings of Alaska Enplaned Passengers 8,146 passengers in 2013 Enplaned Freight 152,516 lbs. in 2013 Enplaned Mail 64,359 lbs. in 2013 Post Offices Public Libraries Esther Greenwald Library Schedule of Hours Monday - Saturday 1 - 6pm Annual Hours Open 1,560


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She made me feel comfortable. She didn't sit behind a desk - she sat down with me and talked to me face to face MORE>>
Sharon Castano Henry Student Center 570-408-2950 (T) 570-408-7794 (F)
Wilkes faculty, and intern/co-op site mentors, students obtain valuable practical experience while organizations obtain capable, young, professionals who are able to help meet goals.
Students who meet academic standards and departmental requirements, and have completed at least 30 credits, are eligible to participate in fall-, spring-, or summer-semester programs.
related to his or her field experience. The internship program requires that the student work at a placement site for a specified number of hours -- part-time during the school year or full-time during the summer. During that time, the student will fulfill learning objectives developed under the guidance of the site supervisor and the faculty coordinator. Academic credit is awarded to Wilkes University students upon achievement of objectives, positive employer evaluations, and a credit-worthy academic project.
submit job descriptions to the Wilkes Cooperative Education coordinator.
prior to each semester. Requests for part-time employees should also be submitted.
in accordance with their majors, based on the organizations' needs. After an employer chooses an appropriate candidate, the intern and supervisor arrange a schedule. Students are expected to be on site for a minimum of 15 hours per week to earn three credits. Students and supervisors arrange mutually convenient schedules and a start date. If it is necessary and beneficial, students and organizations may decide on a start date that is prior to the beginning of a semester.


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U.S. Travel Toolkits
Tools to Help You Communicate Critical Issues
The U.S. Travel Association provides members with ready-made communications resources, such as talking points, sample news releases and op-eds, PowerPoint presentations and graphics, to help the travel community speak with one voice on a variety of critical topics. Recent toolkits distributed to U.S. Travel members are available below.
Travel Means Jobs toolkit
Labor Day and everyday, policymakers and media should recognize travel as an engine for our nation's economic growth and American job creation. Use the resources within this toolkit to spread the word about the important role of travel in creating and supporting jobs in your community.
Keep America Meeting toolkit
Meetings and events matter to the U.S. economy. In 2011, meetings and events generated $99 billion in direct travel expenditures, which supports 859,000 American jobs and contributes $15 billion in tax revenue for local, state and federal governments. Tools provided will help protect American workers and local communities and deliver the message to "Keep America Meeting."
Defend Your Budget
With reductions and even elimination of an entire state tourism office, U.S. Travel wants to help you get your budgets back. Let's make the case for why travel matters – an ongoing effort for all of us, particularly during these tough economic times. U.S. Travel has packaged valuable ammunition to help you fight the good fight and inform your elected officials on why travel and tourism is important and how it supports vital public services.
National Travel and Tourism Week toolkit
This kit includes a number of useful resources, ideas and travel facts to help you plan and stage effective activities in support of the annual National Travel and Tourism Week, including tools to organize a U.S. Travel Rally Day event in your community or state.
International Travel Promotion toolkit
President Obama has signed into law the first-ever national travel promotion and communications program to attract more international travelers to the U.S. The toolkit of resources provides useful templates for crafting messages to your local media and expressing thanks to policymakers in the House and Senate who helped make TPA a reality.
Business Travel ROI toolkit
The analysis on ROI of U.S. business travel by Oxford Economics is a critical tool in the battle to affirm why travel matters, especially for meetings, conventions and exhibitions, and incentive programs. These tools will help you spread the word on business travel's effects on profitability.
H1N1 / Swine Flu toolkit
While it's critical that the travel community do all that it can to ensure spread of H1N1 is limited, these tools assist in vital communication efforts to underscore the critical role travel plays in our economy to ensure appropriate responses as information about swine flu becomes available.
U.S. Travel Councils
Upcoming Events


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Professor Steve Jackson - Associate Faculty
Steve Jackson's research group focuses on understanding how cells detect and repair DNA damage via the activities of the 'DNA-damage response' (DDR). The importance of the DDR for maintaining good health is shown by the diseases that are associated with the alteration or loss of these activities; including neurodegenerative disease, immunodeficiency, premature ageing, infertility and cancer.
Steve graduated from Leeds University in 1983 and then carried out his PhD research working with Jean Beggs on yeast RNA splicing at Imperial College, London and Edinburgh University, gaining his PhD in 1987.
Steve moved to the USA to carry out his postdoctoral research with Robert Tjian at Berkeley, where he developed an interest in the regulation of transcription. He returned to the UK in 1991 to become a Junior Group Leader at the then Wellcome-CRC Institute to continue his research into transcription by eukaryotic RNA polymerases II and III. This work was subsequently expanded to include the transcriptional apparatus in Archaea.
Through characterising the functions of the DNA-dependent protein kinase, Steve was led into the field of DNA repair and DNA-damage signalling. Although a considerable amount of his lab's current work is still focused on pathways controlled by DNA-PK and the related kinases ATM and ATR, his research is increasingly determining how other post-translational modifications, such as protein acetylation, poly(ADP)-ribosylation, ubiquitylation and sumoylation, also control key DDR events.
In 1997 Steve founded KuDOS Pharmaceuticals with the aim of translating knowledge of DDR pathways into new treatments for cancer. KuDOS developed into a fully integrated drug-discovery and drug-development company, being acquired by AstraZeneca in 2005. KuDOS drugs are now being evaluated in a number of clinical trials.
Recently, Steve founded MISSION Therapeutics Ltd with the aim is to translate new molecular understandings of human cell biology into drugs that will markedly improve the management of life-threatening diseases, particularly cancer.
Selected Publications
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Nature chemical biology 2012;8;3;301-10
PUBMED: 22306580; PMC: 3433707; DOI: 10.1038/nchembio.780
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
Molecular cell 2012;45;4;505-16
PUBMED: 22365830; PMC: 3550743; DOI: 10.1016/j.molcel.2011.12.035
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.
Genes & development 2011;25;5;409-33
PUBMED: 21363960; PMC: 3049283; DOI: 10.1101/gad.2021311
Human SIRT6 promotes DNA end resection through CtIP deacetylation.
Science (New York, N.Y.) 2010;329;5997;1348-53
PUBMED: 20829486; PMC: 3276839; DOI: 10.1126/science.1192049
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Nature 2009;462;7275;935-9
PUBMED: 20016603; PMC: 2904806; DOI: 10.1038/nature08657
The DNA-damage response in human biology and disease.
Nature 2009;461;7267;1071-8
PUBMED: 19847258; PMC: 2906700; DOI: 10.1038/nature08467
CDK targets Sae2 to control DNA-end resection and homologous recombination.
Nature 2008;455;7213;689-92
PUBMED: 18716619; PMC: 2635538; DOI: 10.1038/nature07215
Human CtIP promotes DNA end resection.
Nature 2007;450;7169;509-14
PUBMED: 17965729; PMC: 2409435; DOI: 10.1038/nature06337
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.
Cell 2006;124;2;301-13
PUBMED: 16439205; DOI: 10.1016/j.cell.2005.12.031
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
Cell 2005;123;7;1213-26
PUBMED: 16377563; DOI: 10.1016/j.cell.2005.09.038
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Nature 2005;434;7033;605-11
PUBMED: 15758953; DOI: 10.1038/nature03442
A DNA damage checkpoint response in telomere-initiated senescence.
Nature 2003;426;6963;194-8
PUBMED: 14608368; DOI: 10.1038/nature02118


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- Sam Ash Gift Guides
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The PV® 231EQ dual 31-band 2/3 octave graphic EQ brings quality features and low pricing together. Select between 6 dB or 12 dB cut or boost over frequencies ranging from 20 Hz to 20 kHz. Low cut filter switch with status LED helps remove rumble from open mics while the bypass switch with LED indicator is convenient for sound checks. Balanced XLR and 1/4" ins and outs make connections to any system quick and simple.
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Comments about Peavey PV231EQ Dual 31 Band Graphic Equalizer:
Bought this to replace an older very scratchy peavey eq on my FOH run. Don't know if I got a bad one or what but right out of the box this thing adds so much white noise to the signal I might as well be using a noise generator. When all sliders are set to middle (flat), the hiss is terrible. And get this, when I cut the lows from 100hz and lower down, the hiss actually gets louder. Huh? Both channels do the same thing.
Sorry Peavey but this thing's a dud. I am sending it back tomorrow. I have 3 Behringer 3102's I use on my monitor runs and those things are dead silent. Looks like I'm getting another 3102 for the mains.
PV231EQ Dual 31 Band Graphic Equalizer
The manufacturer's warranty covers guitars, basses, amplifiers, pre-amplifiers, mixers, electronic crossovers and equalizers for two years from date of purchase. An extended warranty is available for three additional years of coverage if a warranty card is completed and returned within 90 days of purchase. The warranty excludes damage from misuse, abuse, and contains other exclusions.


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Blue Book® Suggested Retail Value
Fuel Economy (city/hwy)
Flash Drive: 2008 Scion xD
This 2008 review is representative of model years 2008 to 2014.
By Staff of MSN Autos
It may not be the most fuel-efficient, cheapest or the coolest car on the road, but the Scion xD does possess qualities that make it a great daily commuter. The moment I sat in the driver's seat I felt as if I were sitting in a crossover SUV because it was so high. But that's a good thing for anyone who has trouble seeing the road. The xD is a fun little car with decent get-up-and go and good handling. The engine is by no means a powerhouse but it did pleasantly surprise me. As for fuel economy, the hatchback is no Prius but averaged 35 mpg in combined city and highway driving, exceeding the EPA's estimates of 27/33. There is ample room for rear passengers but trunk space is good for groceries only. Starting under $15,000, this is definitely a car for the fuel-conscious to consider. – Johnny Pak
The Scion xD is more stylish than the xA it replaces, but falls short of being able to be called attractive. The short hood, high beltline and squared-off rear give the xD odd proportions. Since form follows function, the odd shape does create useful space inside; the cargo area can hold two large suitcases and a briefcase without folding the rear seat. The aft seat is comfortable for two, and the boxy shape provides plenty of headroom both front and rear. I was able to achieve 32 mpg in combined city and highway driving in the xD, but there's not a lot of power available. This newest Scion works well as efficient, useful transportation, but with the price of our test car exceeding $16,000, the xD is venturing out of the first-car-buyer territory. – Perry Stern
The Scion xD is a great example of how good entry-level cars have become. Priced at $16,444 with stability control and a security system, the xD has an unusual style that provides more driving pleasure than your ordinary econobox. It has a high beltline, aggressive fender flares and standard 16-inch wheels. Although a straightforward, basic car, the xD has responsive steering, linear brakes, a solid feel to the chassis and decent power, yet delivers excellent fuel economy — I averaged 32 mpg overall. The equipment level inside is impressive with comfortable sport seats, both aux and iPod input jacks, steering wheel audio controls, and a cool single gauge that incorporates both the speedometer and tachometer. The red metallic paint is impressive — it smacks of Lexus. The xD makes a great commuter car. – Mike Meredith


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The man explained that giving up his seat was his way of saying thank you to those who serve.
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Variety is the spice of life; complacency in your workouts can be just as dangerous as it is on patrol
Trooper Whitt was shot and killed on the evening of April 12, 1985, during a traffic stop
Two officers were so taken by the girl's spirit that they invited her for a tour of each of their departments


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Fine Stripe Button Shirt
Product code: G570016
Boasting finely striped cotton creating a classic yet individual style. Featuring a button down collar and single cuffs allowing both comfort and ease. Can be worn with a variety of our casual trousers making it a highly wearable piece.
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- Models height 6"0
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Imogene Newland
phone: +44 (0)28 9097 4761
fax: +44 (0)28 9097 4828
room: SARC PhD Lab
Imogene completed a BA (Hons) in Contemporary Music (Performance) and an MA in Choreography from Dartington College of Arts, Devon. She has more recently been awarded a Licentiate of the Royal Schools of Music in piano (performance). Her work addresses the relationship between the female body and the piano in order to create a sociological commentary on the nature of western classical music culture and it's potential for deconstruction and reinstitution. She has presented work at, amongst others; the Arnolfini, Bristol, the Klankkleur Festival, Amsterdam, and at the Tonlistarskoli, Egilsstadir. Imogene is currently undertaking research that examines the body-instrument relationship using and extending the theories of sexuality and eroticism by George Bataille and Michael Foucault.


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Will You Be Our Valentine?> back
February 4, 2011
Call me sentimental, but all the bright hearts and warm wishes of Valentine's Day naturally make me think of everything I love about my daily workout. I totally appreciate the blessings of a healthier heart, tons more energy, a sunnier outlook, a perkier backside, and…(drum roll)…having terrific sports bras that keep me secure and comfortable regardless of how I challenge them!
In the spirit of V-Day, we want to share a little love (and 10 free sports bras for 10 lucky winners of our new sports bra giveaway contest!).
To enter the contest, you simply need to finish the sentence, "I love Champion sports bras because…….!" To be eligible for the drawing, you must enter your sentence in the comment box below and then submit your information here http://www.facebook.com/champion?v=app_181100898568496&ref=ts. All entries must be received between 11:00:00 a.m. February 11, 2011 and 11:59:59 p.m. on February 17, 2011. (You must be 18 or older to enter.) We'll be drawing 10 winners and announcing winners on February 18, 2011, and will send those winners an e-mail requesting size and activity level information in order to select the right sports bra.
I hope you'll take a minute to share a little Champion sports bra "love," and put yourself in the running for a spanking new sports bra for yourself!
> back
Introducing Champion's Sports Bra Expert - LaJean Lawson
In 1977, Champion Activewear invented the first sports bra, called the Jogbra®, made from two jockstraps sewn together. The realization that women also needed support for their assets was the catalyst for Champion Activewear to apply innovation and technology to become the leader in the sports bra market.
In 1977, runner LaJean Lawson had just finished her first marathon with bleeding sores on her shoulders and chest from a bra that did anything but support. Her search for a solution eventually led to the discovery of her life's passion–sports bras!
Today, Champion Activewear is thrilled to offer Dr. Lawson as a resource to help you solve your sports bra problems. While Dr. Lawson has gained critical knowledge from scientific research, the best education she's had about sports bra needs has come from the thousands of women she has spoken to at races and events, as well as those who help her test Champion products.
Whether it's your shoes or your sports bra, your workout happiness depends on finding the gear that's just right for your size and activity level, and that's exactly why we're here to help!


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July 23rd, 2014
Justistal (Justis Valley) in the Bernese Alps, Switzerland. August 2013.
Samsung 18-55 f/3.5-5.6 OIS
Samsung NX10.
Photo Settings: 18mm, f/13, 1/50 second, ISO 100.
Munnar Tea Gardens
By illuminati
July 22nd, 2014
Munnar is a town and hill station in the southwestern state of Kerala, India. Munnar is situated around 1600 m above sea level, in the Western Ghats range of mountains. This hill station is famous for it's tea and tea Gardens
Nikon D800, Nikon AF-S NIKKOR 14-24mm f/2.8G ED.
Photo Settings: 24mm, f/8, 1/125 second, ISO 100.
Map: 10.0892, 77.0597
The Outstanding
By snowlee
July 20th, 2014
Taken in Blue Mountains National Park, Australia.
Adobe Lightroom 5.
Canon EOS 5D Mark III, Canon EF 20mm f/2.8 USM.
Photo Settings: 20mm, f/8, 1/4 second, ISO 100.
Down to Earth
July 19th, 2014
Downtown Vancouver, as seen from Stanley Park. May 2014.
Samsung NX10, Samsung NX 12-24mm F4-5.6 ED.
Photo Settings: 12mm, f/10, 30 seconds, ISO 100.
Rocky Morning
July 18th, 2014
Sunrise off the coast of Texas.
Adobe Lightroom 5.
Vivid Sunset
July 17th, 2014
I saw the most amazing colors in the sky and rushed to the beach to catch the last of it. This was taken from Alki (West Seattle) in July 2014.
Canon EOS 6D, Canon EF 17-40mm f/4.0L USM.
Photo Settings: 22mm, f/5, 6 seconds, ISO 50.
Under Proxy Falls
By theadaptive
July 16th, 2014
This image was the result of a workshop with "Starving Photographer" Mahesh Thapa on July 11, 2014. Mahesh really emphasized that getting in the water and capturing several exposures would give the best results. Man, was he right.
Adobe Photoshop CS6.
B+W Circular Polarizer, and a microfiber cloth from Costco to wipe water off of the lens as much as possible.
Canon EOS 6D, Canon EF 16-35mm f/2.8L II USM.
Photo Settings: 16mm, f/8, 1 second, ISO 100.
Map: 44.1618, -121.9278
The River
By jdphotopdx
July 15th, 2014
A foggy January morning in Oregon along Highway 38.
Adobe Lightroom 5.
Canon EOS 6D, Canon EF 24-105mm f/4L IS USM.
Photo Settings: 24mm, f/5, 1/40 second, ISO 100.
By picturbex
July 14th, 2014
This picture was taken in an abandonned castle in Europe.
There was a guardian with a riffle in the garden when we were inside!
Adobe Lightroom.
Copyright 2000-2014 L-bow Grease, LLC.


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Product Details
This series 1928 $500 FRN from the St. Louis district is a beauty!
Graded About Uncirculated 55 by PMG, this note looks CU at first glance! Only the corner bumps and 1 minor handling fold keeps this example from being Uncirculated. Still a nice high quality note. Woods/Mellon signatures.
An interesting aspect of the Federal Reserve Notes from 1928 is that their redemption wording states, "Redeemable in Gold on Demand at the United States Treasury, or in Gold or Lawful Money at any Federal Reserve Bank." No Federal Reserve Note since 1928 has carried this redemption. Friedberg#2200-H.
Currency -- why buy Currency from APMEX?Currency such as Federal Reserve Notes, Silver Certificates, Gold Certificates and Legal Tender Issues are all popular collectibles and a nice addition to any numismatic collection. Call our Account Managers toll free at (800) 375-9006 or click on the "Live Chat" button. APMEX is where to buy Precious Metals! Also, you can come to us when it is time to sell Gold, Silver, Platinum, Palladium, and Currency.
We provide our customers with a refund and or exchange policy on everything we sell including bullion and certified coins. If for any reason, you have a problem, please feel free to call us. We will always do our best to accommodate you.
|Product ID:
|About Uncirculated 55
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Puzzle - Answer
A couple were invited a local party, they arrived early and were offered some of the freshly made, iced punch. They couldn't stay at the party very long and left early. The next day they found out that everyone else who had drunk the punch had been poisoned and had fallen very ill. Why were the couple not ill?
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Rolex Rankings #65
Rolex Rankings #1
Will Shanshan Feng defend her title?
Will Lexi Thompson defend her title?
Ernst's victory another big step in her career
The Social Scene for September, 2014
LPGA players spend most of their year on the road. Hear their tips to making your travels easy!


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Imagine your organization powered by technology that's beautiful, easy-to-use, and designed to speed performance. New social collaboration tools, enhanced mobility, deep industry-specific functionality, and an intuitive user interface deliver modern solutions that empower you to innovate and stay competitive.
Taking advantage of new, innovative capabilities at the core of Infor 10X has never been easier or more valuable. With the Infor UpgradeX Program, you get your solution reinvented in the Cloud, making the complexity, high costs, and risk of traditional deployments a thing of the past.
Learn more about UpgradeX
Beautiful software purpose-built for microvertical industries? Cloud-enabled? Engineered for speed? Infor is creating a buzz in the marketplace, and you can find out what analysts and the media are saying about Infor's momentum in this freshly published eBook.
Don't let a lack of training hold you back. Infor Education offers innovative learning solutions for every role, schedule, and budget.
Gaming & Leisure magazine honors Infor with its top Platinum Award in its 2014 Gaming & Hospitality Awards presented this week. MorePosted at 09:30 AM on Thu, Oct 02, 2014
CIO, in partnership with Infor, launches website to foster industry specific cloud thinking and best practices. MorePosted at 01:00 PM on Wed, Oct 01, 2014
At Infor, 'the changes are impressive … it's a long list, and it all looks good,' says analyst Enterprise Application Consulting. MorePosted at 10:00 AM on Wed, Oct 01, 2014
Infor's transition to industry cloud company is 'a journey in progress, but the fresh thinking and energy are pretty obvious,' reports Enterprise Irregulars. MorePosted at 01:00 PM on Tue, Sep 30, 2014
Industry analysts and the media have much to say about all the product innovations and other news coming out of Inforum. Here's a sampling. MorePosted at 12:30 PM on Mon, Sep 29, 2014
At Inforum 2014, Infor announced Infor CloudSuite Business and a swap-out program for NetSuite customers, TEC reports. MorePosted at 01:30 PM on Thu, Sep 25, 2014
ZDNet says conventional software vendors 'will be in trouble as Infor basically upped the ante' with Infor CloudSuite Financials. MorePosted at 11:30 AM on Wed, Sep 24, 2014
SiliconANGLE reports Infor has achieved something Oracle and SAP could only dream of—transformed itself into a fully fledged cloud-based software company. MorePosted at 12:30 PM on Tue, Sep 23, 2014
Our approach spans 12 focus industries and offers deep micro-vertical functionality tailored for your business processes, eliminating the need for costly customizations.
200+Countries & territories


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Explore COPD
COPD, or chronic obstructive pulmonary (PULL-mun-ary) disease, is a progressive disease that makes it hard to breathe. "Progressive" means the disease gets worse over time.
COPD can cause coughing that produces large amounts of mucus (a slimy substance), wheezing, shortness of breath, chest tightness, and other symptoms.
Cigarette smoking is the leading cause of COPD. Most people who have COPD smoke or used to smoke. Long-term exposure to other lung irritants—such as air pollution, chemical fumes, or dust—also may contribute to COPD.
To understand COPD, it helps to understand how the lungs work. The air that you breathe goes down your windpipe into tubes in your lungs called bronchial (BRONG-ke-al) tubes or airways.
Within the lungs, your bronchial tubes branch into thousands of smaller, thinner tubes called bronchioles (BRONG-ke-ols). These tubes end in bunches of tiny round air sacs called alveoli (al-VEE-uhl-eye).
Small blood vessels called capillaries (KAP-ih-lare-ees) run through the walls of the air sacs. When air reaches the air sacs, oxygen passes through the air sac walls into the blood in the capillaries. At the same time, carbon dioxide (a waste gas) moves from the capillaries into the air sacs. This process is called gas exchange.
The airways and air sacs are elastic (stretchy). When you breathe in, each air sac fills up with air like a small balloon. When you breathe out, the air sacs deflate and the air goes out.
In COPD, less air flows in and out of the airways because of one or more of the following:
In the United States, the term "COPD" includes two main conditions—emphysema (em-fih-SE-ma) and chronic bronchitis (bron-KI-tis). (Note: The Health Topics article about bronchitis discusses both acute and chronic bronchitis.)
In emphysema, the walls between many of the air sacs are damaged. As a result, the air sacs lose their shape and become floppy. This damage also can destroy the walls of the air sacs, leading to fewer and larger air sacs instead of many tiny ones. If this happens, the amount of gas exchange in the lungs is reduced.
In chronic bronchitis, the lining of the airways is constantly irritated and inflamed. This causes the lining to thicken. Lots of thick mucus forms in the airways, making it hard to breathe.
Most people who have COPD have both emphysema and chronic bronchitis. Thus, the general term "COPD" is more accurate.
COPD is a major cause of disability, and it's the third leading cause of death in the United States. Currently, millions of people are diagnosed with COPD. Many more people may have the disease and not even know it.
COPD develops slowly. Symptoms often worsen over time and can limit your ability to do routine activities. Severe COPD may prevent you from doing even basic activities like walking, cooking, or taking care of yourself.
Most of the time, COPD is diagnosed in middle-aged or older adults. The disease isn't passed from person to person—you can't catch it from someone else.
COPD has no cure yet, and doctors don't know how to reverse the damage to the airways and lungs. However, treatments and lifestyle changes can help you feel better, stay more active, and slow the progress of the disease.
What is COPD?
What is COPD?
Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. To find clinical trials that are currently underway for COPD, visit www.clinicaltrials.gov.
May 18, 2014
NIH-funded studies find statins provide no benefit to COPD, ARDS outcomes
Statin therapy does not prevent exacerbations of chronic obstructive pulmonary disease (COPD) or lower mortality from acute respiratory distress syndrome (ARDS), report two studies that rigorously tested the benefit of the cholesterol-lowering drugs on outcomes in the lung diseases.
September 2, 2014
Gary H. Gibbons
Researcher Brings Medicine One Step Closer to Widely Available Cure for Sickle Cell Disease
The NHLBI updates Health Topics articles on a biennial cycle based on a thorough review of research findings and new literature. The articles also are updated as needed if important new research is published. The date on each Health Topics article reflects when the content was originally posted or last revised.


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Hot or Not? Slicing Guide
This slicing guide is a product that we instinctively feel like we should ridicule. What a unitasker! And yet we are so uncoordinated that our tomato slices often come out either wispy or chunky — and don't even talk about our bread slicing clumsiness. Precise slicing is definitely an area of growth for our knife skills. So perhaps this has some guilty merit. But then again, maybe you could hack this with a large carving fork? What do you think?
• Buy it: Slicing Guide, $9.95 at Solutions
Related: Hot or Not? Can Colander/Strainer
(Images: Solutions)
12 Comments
I think it's rather silly, but I'm always wary of slicing that last chunk of tomato for fear of cutting myself... maybe this would be easier.
I want to vote "Not!" but my left thumb, which I cut yesterday, is telling me to vote "Hot!"
My mother-in-law has a similar tool and uses it for perfect little tomato slices. I agree it seems silly, but if you entertain a lot it might actually be quite handy.
I usually make a mess of slicing, so I gave it a try, but I found it awkward to use and still made a bit of a mess (but that's probably just me).
I think that a mandolin slicer would work better for things like tomatoes and lemons -- and it wouldn't work on large loaves of bread which is what I'd need it for. I don't have anything against slicing guides, but I'm not sure I'd buy this one.
@mlleErica, a mandolin will butcher tomatos, I can tell you that from personal experience. I've never been able to get mine sharp enough to not tear them apart.
I want to say "NOT!" because it seems silly but slicing tomatos is kind of a pain, especially since I tend to slice diagonally with a serrated knife. Practice has let me get nice, evenly fine slices of naked lemons, though, so maybe that's what it would take rather than a gadget.
I couldn't get the vote button to work after following the directions, but I'd add HOT because I love the idea of not slicing up my fingers or finger nails and getting perfectly sized slices. It seems to hold the meat nicely also, which would be a plus when it is hot.
The only NOT point is that I don't have room to store it, which really is the problem with all unitaskers that actually get the job done.
Not.. just work on your knife skills and keep your knives sharp.
These tools also lock you into certain slice widths... good skills let you slice as needed.
This looks awkward. I loathe slicing tomatoes so my friend bought me a tomato slicer from Target that's sort of like an egg slicer without the hinge. It works pretty well.
While gadgets like this often incite dismay from serious cooks who work on techinque and knife skills, they are actually very useful for people who have mobility issues.
I have several family members who have range of motion issues with their hands and this gadget can really help them to cut fresh food safely. So don't be too quick to dismiss an item like this...
We had something like this (a little larger) for slicing our homemade bread. It was nearly impossible to get sandwich sized slices without it. I don't slice lemons often enough to care, but it would also be great to not have to get the acidic juices all over my hands (and hangnails).
I wouldn't buy one, but I like the concept so I voted Hot.
After working with a caterer for a while, I learned some good cutting/chopping techniques, but I still tend to make a mess of tomatoes. And I think if you are using the tomato/lemon in nicely presented meal, it would be great to give everyone uniform pieces.
I voted Not because I'm not into unitaskers and gadgets. I would buy it for my brother for Xmas though--he and his wife have every kitchen thingy-do made (and a kitchen half the size of my entire apartment).
Funny--I'm always saying I need to work on my knife skills, but the fact is, I can evenly slice tomatoes, lemons, bread, etc., without stress, so I'm going to give myself 10 points. I'd love to be faster, but I guess I'm not too bad.


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Back to Graphic Version | SAMHSA
News Home
SAMHSA recently released a report that details changes
to the Agency's National Registry of Evidence-based Programs
and Practices (NREPP). The report was published in the
March 14 Federal Register, and it is also available on
the SAMHSA Web site.
Historically, NREPP has served as a nationally recognized
tool to identify and promote interventions that work
to prevent substance abuse. The new changes, which follow
an extensive period of public comments, will broaden
NREPP to include the latest information on the scientific
basis for specific programs and interventions to prevent
and/or treat mental health and substance use disorders.
The new protocols and procedures are designed to help
reduce the significant lag-time between new scientific
knowledge and its application by community-based prevention
and treatment programs and providers. The changes provide
transparency, accuracy, and timeliness of both the NREPP
process and the end product—the registry itself.
By Fall 2006, SAMHSA anticipates the launch of a new
NREPP Web site. For more information, including a copy
of the NREPP report, visit SAMHSA's
Web site.
Back to Top
Back to Graphic Version


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Hello there, how can we help you today?
We're a social media, mobile, and community consultancy focused on helping your company do its job better.
Whether that means developing the best mobile and tablet applications, harnessing user feedback to help with product development, facilitating intra-company communications, using social support tools to increase customer satisfaction or social-charging your marketing and sales efforts, we are here to help you get it done.


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WOBURN, Mass. (MyFoxBoston.com) – Authorities found pieces of an explosive device near the Woburn-Burlington line for remnants after a suspect taken into custody on Elm Street Wednesday afternoon told them he had recently detonate two pipe bombs in the area.
According to the Woburn police, the parents of 24-year-old Adam Crane called police at about 12:30 p.m. Wednesday because they were concerned about their son's well-being. Crane's parents told police their son had recently been kicked out of the military.
Police responded to 79 Elm Street, the home Crane shares with his parents, and attempted to coax Crane out of the home.
The police chief told FOX 25 at first the suspect was resistant, but after some time came out of the home.
Police said Crane cooperated with police and told them he had explosive material inside the home, but not an actual bomb.
The K-9 Unit was sent into the home, and the bomb squad unit was sent into the Linscott-Rumford Elementary School, which is located right across the street from Crane's residence, to make sure the students were safe. The school was deemed secure and the students were dismissed at their normal time.
Thus far, Crane has been charged with possession of bomb making materials; however, the investigation is ongoing.
Police searched the Mill Pond Reservoir for the two pipe bombs Crane told police he had recently detonated.
More charges could be brought against Crane as a result of the discovery of the explosive remnants.
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Mara Vinson and James Moore in Kiss. Photo © Angela Sterling
Peter Boal's annual roundup favorites and new works features three contemporary works by female choreographers, plus a world premiere by Spanish-born Alejandro Cerrudo (resident choreographer of Hubbard Street Dance Chicago) combine for a mixed-repertory showcase custom made for fans of genre-busting dance. TAKE FIVE… More or Less, Broadway-darling Susan Stroman's sunny slice of jazz-infused Dave Brubeck fun joins Kiss, a performance art/dance/aerial duet that stands alone in its distinctiveness. Molissa Fenley's State of Darkness, choreographed to Stravinsky's riot-inducing The Rite of Spring, is a tour-de-force solo performance for either a male or female dancers (Peter Boal was one of the first to dance it). The much-anticipated new arrival by Alejandro Cerrudo complements a Rudolf Nureyev Prize for New Dance. Cerrudo's works "…enthrall audiences all over the world…" (Huffington Post).
Alejandro Cerrudo's World Premiere commission for PNB was created with the support of a Rudolf Nureyev Prize for New Dance awarded by The Joyce Theater with major funding from the Rudolf Nureyev Dance Foundation.


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Part of our One Hit Wonders series, featuring great new documentaries at special one-night-only screenings!
"Fascinating to watch." – Jennifer Swan, Time Out Chicago
"A revealing documentary that deals with nuns facing change."– John Hartl, Seattle Times
"Inspiring! A heart-felt documentary celebrating the incredible achievements of activist Catholic nuns in the United States." – Frederick and Mary Ann Brussat, Spirituality and Practice
In Band of Sisters, two nuns advocate for the rights of immigrant detainees and deportees in and around a Chicago-area deportation center. It is 50 years since Pope John XXIII opened the Second Vatican Council to let a little fresh air in the church, and most Catholic nuns in the US have never looked back. Fascinating scenes of convent life prior to Vatican II contrast with those of nuns in the tumultuous and exciting years after the Council, when sisters became engaged with the great social movements of the day. Adeptly illuminating the path from direct service to social justice to the transformation of consciousness, Band of Sisters travels with sisters who continue their mission as organic farmers, environmental attorneys, peace activists, holistic health practitioners, podcasters and more. With poignancy, drama and humor, the film fosters well-deserved recognition for its engaging characters and the thousands of sisters like them. In the face of obstacles and threats cast by government agencies, the military, and the hierarchy of their own church, the forward-thinking US nuns are on a mission of love, and it appears that nothing can stop them. A film that shows the sisters as they are, Band of Sisters is a deeply moving story of inspiration and hope for people of all faiths. (Dir. by Mary Fishman, 2012, USA, 88 mins., Not Rated) Digital
Visit the official movie website


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Don't Let Captain Hindsight Pick Apart Your Portfolio!
Margie is a member of The Motley Fool Blog Network -- entries represent the personal opinion of the blogger and are not formally edited.
There is a great Southpark episode where the "superhero" Captain Hindsight flies to the scene of a burning fire to save the day as the building occupants scream for help: "Those fire escapes should've been been built closer to the windows! And the nearest fire hydrant shouldn't have been two blocks away. And putting the extra coat of varnish on the outside of the building was a huge mistake!"
"Thank you Hindsight! Godspeed Captain Hindsight!" the relieved citizens and fire fighters coo as he takes back off into the air, ala superman, his cape blowing in the wind, as the building collapses.
Investors hail Captain Hindsight as a genius, and there are plenty of Hindsights roaming the broadcasts of CNBC, but listening to General Present generally goes against the grain, and most investors find it incredibly painful to do so.
Sometimes it can be incredibly simple for General Present to see the lay of the land. In 2005, I begged my brother not to purchase a house in the Los Angeles area, as to me it was obvious that we were in a housing bubble simply because there were truckers earning $30,000 a year being given $600,000 loans and house keys.
"How could they ever pay that off? When those teaser rates reset, the banks are going to foreclose, prices are going to go back down with the extra supply," I warned.
How many people listened to the warning signs? What happened to investors money as they kept investing in banks stocks? Lehman, Bear Stearns, Wachovia, where are they today? How about the stock prices of Citigroup and Bank of America, and what happened to the broader market during the following years?
I don't want your portfolio to be that burning building, so General Present is going to reiterate some analysis on your favorite companies she has stated before, that will win her far fewer popularity points than when Captain Hindsight arrives to clean up the mess.
Apple (NASDAQ: AAPL) loyalists will fight my opinion tooth and nail, and have called me various names, idiot being the kindest--
General Present states- in order to maintain the absurdly high profit margins on its hardware, the company must continue coming up with new super cool, cutting edge products that push the edges of technology as we know it. Products from Google, Samsung, and even Nokia and Microsoft are catching up to the vast lead that Apple once had. The iPad Mini, despite selling for $130 more than the Google Nexus and the Amazon Kindle, doesn't win most reviews.
When the original iPhone came out, it was an amazing leap in technology. Apple was able to charge a king's ransom for the phone, and people and the cell phone carriers gladly paid it. The iPhone 5 is still a great product, but many people think it's close to a coin flip between the Samsung Galaxy and the iPhone, and the winner depends on your particular tastes.
Now, when a competing product approaches the same quality- price enters into the picture. With the super high margins, there becomes room to drop the price. Based on this, Apple might be forced to drop prices, at the expense of its bottom line, to stay competitive.
Yes, I realize that some people are willing to pay more for Apple products simply because they are Apple. That cool factor, snob appeal, comes in part from society being mesmerized by Apple's continued ingenuity.
And let's give Apple the benefit of the doubt and say that they have another WOW product in the pipeline, however, the more time between such products, the more Apple's "cool appeal" (and thus pricing power) will seep away. I assure you this is a large part of the recent slide in share price.
Fact: Amazon (NASDAQ: AMZN) is in the process of losing its greatest advantage in Internet retail- the ability not to charge its customers sales tax. It is an economic fact that higher prices means fewer sales (law of supply and demand). CEO Jeff Bezos has done an admirable job growing Amazon, and a large part of the reason the price earnings ratio of nearing 3000 is because many investors understand the he is continually reinvesting Amazon's profits into new product lines and services.
However, with margins at just over 1%, they have no room to cut prices on the products they are selling. Many of their current and future sales will be transferred to companies like Wal-Mart online, or customers headed to various retail locations to get whatever they need today. (To combat this Amazon is building warehouses/ fullfillment centers closer to large population centers they weren't previously in, for tax purposes). That's not to say that Amazon isn't also the 800 pound gorilla of cloud services. I have heard some investors state Amazon is mostly a cloud play, but with a heavy investment in infrastructure; I believe this is inaccurate.
When sales growth starts to dip, as they invariably will, that price to earnings ratio of 3000 might start to look very scary.
This is much less of a warning, as Google (NASDAQ: GOOG) is definitely addressing this issue, but this is certainly a metric to watch. The simple fact is that humanity is going to be accessing the Internet more and more from tablets and cell phones than in previous years, and Google still derives 90% of its profits from advertising, mostly desktop.
A friend of mine works for an Internet advertising placing company was specifically told not to buy Google mobile ads because they don't do nearly as well as on the desktop. The company, despite the cheaper prices, still thought it wasteful. Another reason- security is not nearly as good on cell phones as it is on laptops, which certainly affects consumers purchasing decisions. As over 90% of Google's profits currently come from advertising, they're hard at work attempting, with their Android platform, to delve into mobile, and are certainly ahead of their competitors in this realm. However, the game is much more wide open than the desktop, and players like Apple with Siri, and Facebook, are trying to eat Google's lunch. I'm a big Google fan, have been since $500 a share, but I'd be adding a lot to my position if even twenty people I know told me they were comfortable buying things over their cell phones. This is yet to hapen, so watch out.
Let General Present leave you with a pleasant version of the future instead of fires. The world will see a rapid accelaration of robotics. You probably already know someone with the IRobot (NASDAQ: IRBT) Roomba (I have one and love it) and the company is trading at levels not seen since before the aftermath of the financial crisis, and has zero debt on its balance sheet. Shares have dropped as the US government has cut back on purchases of military robots, but I want to invest in the trend of robotics, the possibility of the company being aquired by a larger player, etc. General Present says the future is robots, with tremendous room for growth.
Captain Hindsight appears in all our lives at one point or another, and he can be a useful companion by allowing you to see mistakes you made/ things you didn't see in the past and to apply them to the now. Captain Hindsight is there to sharpen General Present's ability to analyze and make bold decisions today. Hopefully General Present is correct, because I don't want Captain Hindsight cleaning up my mess.
margiecfl has positions in Google, Apple, amd iRobot. The Motley Fool owns shares of Apple, Amazon.com, and Google. Motley Fool newsletter services recommend Apple, Amazon.com, Google, and iRobot . Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.If you have questions about this post or the Fool's blog network, click here for information.


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Wild Edible Plants of New Brunswick
This guide provides a list of wild edible plants in New Brunswick (Canada) including the Fredericton, Saint John, and Moncton areas and the Fundy and Kouchibouguac National Parks.
This list only contains "safe" plants - those that are easy to identify and have no deadly poisonous look-alikes.
All plant parts described as being edible raw are also edible (and often more palatable) when cooked.
Learn about getting a printed version of the guide for your area.
Wild Edible Berries of Alberta: A Field Guide is now available (30% Sale)
Click the Google +1 button if this guide was a useful search result for you.


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Sewer rates fly higher and faster
Blaine city council members may have had questions about the date another rate hike would be coming to Blaine sewer customers, or if the rate structure should be changed, but they were stoic when it came to the recommendation rates go up higher, and faster, than was projected last year.
Consultant Edward Cebron said his firm had reviewed current rates, which went up 25 percent in January 2005, and the new Blaine sewer plant project that has led to the ballooning rates. "There is more impact sooner and we have to raise rates more aggressively," Cebron said at an October 4 Blaine City Council work session.
The new wastewater treatment plant is now scheduled to be on-line in 2009, a year earlier than anticipated, so while last year they were recommending a nine percent increase in 2006, today Cebron suggested the city raise rates another 12.5 percent, from $49.90 to $56.14 for residential customers. From 2006 to 2010 the current recommendation is for rates to rise between 12 and 12.5 percent annually, after which they would level off just shy of $80 a month, up from just under $40 in 2004.
"The main thing happening here is that more of the costs are towards the front," Cebron said. "That comes from a better understanding of what will be built when." Projections for the cost of the total project may have dropped by $2.4 million, he explained, but costs in the 2005 to 2009 period rose by $1.4 million. The new wastewater treatment plant slated for Marine Drive just west of Blaine Marine Park and the addition of overflow storage under Marine Drive is anticipated to cost $34 million. Cebron said they had also added costs for replacing aging infrastructure in existing city facilities to their formula when trying to determine what level of rates would be needed to meet the sewer utility's financial obligations.
Cebron also said they had to adjust figures based on a drop in anticipated grant and loan funds available. "The total amount coming in from outside sources is lower," he said. Cebron said that state low-interest loans were less available and city public works director Steve Banham said he was concerned federal grant funds would be squeezed just when the city needed them. "I'm concerned about the federal funds," he said. "With what happened with the hurricanes it's a lot tougher."
January 1, 2006 Cebron is also proposing connection fees
go up $275 more than anticipated in 2004, giving Blaine
the highest hookup fees in the county by more than $200. "But
we're the only ones building a plant," reasoned
mayor John Liebert. Today it costs $4,200 to connect
to the Blaine municipal wastewater system and the
current projection is for that figure to go to
$6,357 by 2010, Cebron said.
Cebron said they would review the rates every year as the project moves forward, and that a web of factors could move rates higher or lower than now anticipated.
"Growth has an enormous impact," he said. Their current projections assume a three percent growth rate, which translates to 75 new homes in 2006. If growth is faster in coming years, such as the 140 new homes that paid in 2004 to hook up to the system, that could mean more revenue from connection fees and less of a need for higher rates. "The problem is that creates the need for the new plant sooner," said city manager Gary Tomsic. "If the high growth rate continues and the project doesn't speed up we will need to address the growth issue." Tomsic also said he didn't want users to think the new plant, and the new rates, were only needed because the city was growing. "We're sizing the plant to accommodate growth but what we have today won't work in the future for the people who live here today."
Cebron said the city could lessen the impact on rates by getting more money up front, whether by issuing revenue bonds to secure low interest rate loans from the state public works trust fund, or by forming utility local improvement districts to collect connection fees from proposed developments. Looking at the first of these scenarios Cebron said "the result was pretty remarkable, about a $3 per month drop in the 2010 rate."
Blaine sewer rates for residential customers today are fixed – every household pays the same amount. Cebron suggested that rates with a volume-based component could be looked at in the future but would only add to confusion if the transition was layered on top of the current regimen of rate increases. "You could wind up with lots of customers paying $20, but you'd also have the flip side with some users paying $100 a month," he said.
Council member Bob Brunkow wanted to know where the increase would put the city relative to other council municipalities. "We are significantly more," Banham said. "In the state small cities looking to replace their plants are all looking at rates like these."
This was the first presentation of the proposed rate increases and Banham said staff would bring the subject back to council for further discussion before a recommendation is adopted in time for the increases to go into effect at the beginning of 2006.


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January 2
Wednesday, 6:00 pm
"Great Battles" Evening Lecture
Gettysburg: History and Hype
It is conventional to depict Gettysburg as a decisive Union victory, the turning point in our Civil War. But that conflict dragged on for nearly two years after Gettysburg, and the fierce resistance mounted by Confederate armies in Virginia and Georgia in the spring and summer of 1864 almost caused a war-weary Northern public to lose its will to continue fighting and turn Abraham Lincoln out of the White House. This lecture compares this battle with other truly decisive Union victories, and considers our distorted view of what the Civil War was really like—which blinds us to the kind of nation that the war produced. Dr. Gregory J.W. Urwin, Department of History, Temple University, speaks at this "Great Battles: Moments in Time that Changed History" series lecture program. Admission with advance registration: $5, general public; $2, Museum members; $10 at the door based on availability.


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Please confirm that your email address is correct, so you can successfully receive this alert.
Dr. Kubicki reports no financial relationships with commercial interests.
Address correspondence and reprint requests to Dr. Kubicki, Psychiatry Neuroimaging Laboratory, Brigham and Womenâs Hospital, Harvard Medical School—Psychiatry, 1249 Boylston St., Boston, MA 02215; email@example.com (e-mail). Editorial accepted for publication January 2010.
, 2010.
Copyright © American Psychiatric Association
Schizophrenia is a heterogeneous disorder that is marked by considerable variation in both its expression and pathophysiology. Central to the illness, however, are widespread cognitive deficits in reasoning, perceiving, remembering, and concentration, all of which are often, but not always, evident by a diminution of scores across neuropsychological tests of intelligence, attention, and memory (for instance, see references 1 and 2). These neuropsychological impairments have long been presumed to reflect underlying neuropathology. However, only relatively recently, with the advent of high-resolution brain imaging studies, has the nature of the relationship between disease-related changes in brain anatomy and cognitive function begun to unfold.
An article in the current issue addresses an important issue related to the neuropsychology of schizophrenia. In this imaging study, Pérez-Iglesias and colleagues (3) examined the relationship between fractional anisotropy (a measure of white matter coherence, organization, and myelination derived from diffusion tensor imaging [4]) and neurocognitive deficits in a group of patients in their first psychotic episode. The authors used maps of brain white matter integrity and four neuropsychological tests (Continuous Performance Test, Grooved Pegboard Test, Rey Auditory Verbal Learning Test, and Trail Making Test Part B) that tap into four cognitive domains known to be impaired in schizophrenia: executive function, verbal memory, attention, and motor dexterity. An analytic approach called voxel-based morphometry (5) was used, and attempts were made to find corresponding anatomical features across all subjects and to analyze group differences in white matter integrity at each picture element (voxel). Four independent analyses were performed, in which patientsâ anatomical data were divided according to whether the patients did or did not have a particular cognitive deficit and the data for the two groups were compared.
The results revealed clusters (groups of voxels) of reduced white matter integrity corresponding to cognitive impairments on two of the four tests administered. That is, impairment on the Trail Making Test Part B was associated with reduced fractional anisotropy in the right and left anterior thalamic radiation and inferior fronto-occipital fasciculus, forceps minor, and left superior and inferior longitudinal fasciculi. Additionally, patients with impaired performance on the Grooved Pegboard Test showed reduced fractional anisotropy in the forceps minor, inferior fronto-occipital fasciculus, anterior thalamic radiation, and corticospinal and corticopontine tracts. Impairments on the Rey Auditory Verbal Learning Test and Continuous Performance Test were not associated with significant differences in fractional anisotropy.
The results of this investigation provide new and interesting insights into the links between cognitive symptoms and white matter abnormalities in schizophrenia. The notion of a direct relationship between neuropsychological performance and white matter integrity measured with diffusion tensor imaging is interesting, but it is also somewhat controversial. More specifically, for every study that shows such a relationship, there is at least one that does not (for a review, see reference 6). This problem gets more complicated because most of the studies of schizophrenia that used diffusion tensor imaging were based on relatively small samples of chronically ill subjects, thereby introducing possible confounds of extended medication use, institutionalization, age, and other factors that are often present in patients with chronic schizophrenia. Thus, studies like this one—performed on a relatively large (N=49) group of mostly unmedicated (or medicated for a very short time), young subjects—are important and needed.
Findings from this study suggest that moderate to severe deficits in executive and motor functions might be linked to structural deficits in white matter tracts that connect frontal and temporal as well as frontal and subcortical brain regions, at very early stages of the illness. These results also indicate that attention and verbal memory deficits, even though present in schizophrenia, might not be related to abnormalities in white matter integrity, at least not in the early stages of this illness. An interpretation suggested by the authors, that the "attention deficits during the first episode of psychosis might be attributable (at least in part) to transient factors like acute symptoms or medication, and therefore subject to variation over time, and less likely to be related to structural abnormalities," is interesting but needs to be further tested in studies with longitudinal designs, especially in regard to the fact that the relationship between white matter integrity and attentional deficits in chronic schizophrenia is among the most frequently reported in the literature (7—10).
As the authors note, it is important to list and discuss some limitations of this research, as well as those of other, similar studies. Despite over 14 years of research, diffusion tensor imaging is still in its infancy when it comes to clinical applications. In general, two of the major limitations of clinical research with this technology, which have hampered progress in the field, are 1) variability in acquisition and analytic techniques and 2) lack of validation of the methodology, including derived white matter measures. While the former is probably responsible for most of the inconsistencies in the literature on diffusion tensor imaging studies of schizophrenia, the latter is even more significant. More specifically, despite over 80 studies that have been published to date that used diffusion tensor imaging in schizophrenia research, it is still not known whether when we report group differences in fractional anisotropy, or any other popular or less popular diffusion index, what we report are abnormalities in myelination, axonal integrity, variability in tract orientation and organization, all of these, or none of these. It is still also not known how different parameters of image acquisition, processing, and analysis impact results and whether results indicate real white matter abnormalities or are merely indicative of biases introduced by specific image analysis approaches (in the case of voxel-based morphometry, used in this study, errors in automatic normalization, segmentation, and registration). It is further not known how age, medication, eating and drinking habits, etc., influence the diffusion tensor imaging signal.
Diffusion tensor imaging is nonetheless the most powerful tool to date with which to visualize and quantify abnormalities in human brain white matter connections in vivo. The degree to which it can be reliably used to indicate neuropsychological disturbances in schizophrenia, however, remains to be determined. Clearly, more research is needed in order to understand biological sources of anomalies in the diffusion tensor imaging signal, as well as clinical and cognitive correlates of such anomalies.
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HOUSTON -- The greatest catch in Thursday night's Houston Astros game wasn't made by a player. It happened in the 13th inning as the Astros took on the Detroit Tigers.
Bryan Pena, a catcher for the Tigers, hit a foul ball that took a bounce and headed into the stands.
However, a father in the stands didn't let the fact that he was holding a small child stop him. He caught the foul ball with his baseball cap, while still holding onto his kid.


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AT&T launches new "affordable" pre-paid smartphone plan, cost more than everyone but Verizon
Today AT&T announced they were lowering the price of their GoPhone pre-paid smartphone plan to $65. This new rate plan includes unlimited minutes, unlimited text, and 1 GB of data. AT&T claims this new rate plan is affordable, but that's only when you compare it to Verizon.
"As more of our prepaid customers choose smartphones, ... Read More »


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Should You Buy & Hold These 3 Stocks?
David is a member of The Motley Fool Blog Network -- entries represent the personal opinion of the blogger and are not formally edited.
To value BioPharma, you need to look at the future and consider long-term catalysts under the context of short-term negative catalysts. While many large drug manufacturers do face large patent cliffs and poor upcoming results from highly speculative candidates, it's the long-term that matters in the end. Below, I review 3 major producers with the focus being on a potential "buy-and-hold" strategy.
Bristol Myers (NYSE: BMY)
Pfizer isn't the only major biopharmaceutical company reeling from exclusivity losses. Bristol has seen Plavex revenue fall 96% from the loss of patent protection. This issue is of particular concern in light of the Supreme Court's recent "green light" on reviewing "pay for delay" practices whereby drug manufacturers pay generic producers to hold up on developing alternatives. "Pay for delay" has been estimated to contribute $3.5 billion each year to the top-lines of pharmaceutical companies.
Despite poor third quarter performance, which came below expectations, management guided to the upper-end of FY12 EPS $1.90 - $2 forecast, which is above expectations. While the positive surprise could send shares higher in the near-term, it's the long-term that matters for BioPharma. Here's what Bristol has ahead of itself:
- Blood thinner Eliquis showed an 81% reduced risk of vein and blood clotting compared to placebo. If approved, this product would contribute $4.2 billion by 2017, or $2.4 billion in present terms. This product, however, will be met by considerable competition: (1) Boehringer Ingelheim's Pradaxa and (2) J&J's Xarelto.
- The company's HCV (Hepatitis C) treatment had a good showing in the Phase IIb study. The candidate illustrated the efficacy of drug combinations by successfully producing a sustained virology response in patients. At the same time, this drug will come under considerable competition from Gilead (NASDAQ: GILD), the lead innovator in STD treatments. In its Phase III study, Gilead's HCV treatment sofosbuvir cleared HCV in nearly four-fifths of patients with genotype 2 or 3 HCV. Ultimately, I see more upside for Gilead's candidate in light of the company's proven role in this market.
Gilead, for example, has also delivered strong results in the HIV market. Its Atripla drug is the lead treatment and is about to be complemented by two other HIV drugs under development. Stribild, which is marketed at $28 thousand per patient, was approved in August 2012 for new treatment patients after a Phase III study demonstrated non-inferiority compared to Atripla and Truvada plus ritonavir-enhanced atazanavir. And Complera, another candidate for treating HIV, even showed statistical superiority to Altripa in adults with low baseline viral load and was non-inferior to those with high baseline viral load. Gilead trades at 16.9x forward earnings versus 17.8x for Bristol. Analysts are generally more enthusiastic about the former, and so am I.
Lilly (NYSE: LLY)
Lilly is cheaper than both at only 13x past earnings and a strong 4.1% dividend yield. Analysts are expecting a 4.7% annual EPS decline over the next 5 years, but I find that this is much too pessimistic. The median price target of $52.10 is also at only a 9% premium to the prevailing price. This pessimism has been reinforced by two negative catalysts in recent days: (1) the halting of tabalumab's Phase III study in rheumatoid arthritis patients and (2) a delay in seeking approval for Alzheimer's treatment solanezumab.
Solanezumab failed to produce positive Phase III data in patients with mild to moderate Alzheimers, and tabalumab produced a lack of efficacy altogether. With that said, the scientific background behind solanezumab is promising, since it did show greater blood levels of beta amyloid, a protein believed to be related to Alzheimer's, exiting the brain. Further, tabalumab is not "dead in the water" but will be studies in patients with systemic lupus erythematosus in two Phase III studies.
But then there are the positive catalysts that have gone under-recognized. First, management has showed an increased interest in targeting emerging markets. Strides Arcolab, an Indian company, recently partnered with Lilly in distributing cancer generics to emerging markets. Management has also said that they will expand offerings in China. Further, there has been a series of positive approvals. The EU has approved 5 mg of Cialis for treating prostatic hyperplasia, which is a good complement to its erectile dysfunction approval a decade ago. The FDA also gave the green light on Alimta, which can be taken by lung cancer patients after first-line treatment for maintenance therapy. The regulatory agency reached this decision in light of existing Phase III data indicating improved survival with maintenance.
Gong forward, there are several other positive catalysts. Type 2 diabetes treatment dulaglutide met its primary endpoint in three Phase III studies. An indicator of blood sugar, hemoglobin A1c, fell with minimal adverse side-effects upon treatment. Finally, a Phase III study for gastric cancer drug ramucirumab looks promising. This candidate also met its primary endpoint in increasing survival rate and even prevented the cancer from worsening. In light of Lilly's cheap price tag and favorable pipeline foundation, I encourage buying shares.
TakeoverAnalyst has no positions in the stocks mentioned above. The Motley Fool has no positions in the stocks mentioned above. Motley Fool newsletter services recommend Gilead Sciences. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy. Is this post wrong? Click here. Think you can do better? Join us and write your own!


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Switchfoot's 'The War Inside' Video Premiere
We're sure you've heard of the rock band "Switchfoot", but what you might not know about them is their passion for surfing and the culture that goes with it. Growing up in sunny San Diego, the members of the band have been surfing their entire lives and get involved in the sport whenever they can. Still not convinced of their love of surf? Just look at their name… it actually refers to the pretty fancy footwork on your board when you switch your feet and change direction.
So when we were asked to premiere their exclusive live performance video of "The War Inside", we were happy to support the cause!
Check out Switchfoot's behind-the-scenes video from their episode of Guitar Center Sessions for the first time right here…


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Sioux Falls, SD (KELO AM) - At 9:30 a.m., on Monday morning, November 4, 2013, Dakota Avenue will be closed to through traffic between 14th Street and 17th Street. Access for local traffic will be maintained at all times.
The City of Sioux Falls Public Works Department will be installing utilities. The work is anticipated to be finished by the evening of November 5, 2013.
Motorists are urged to use caution and reduced speeds while travelling through the construction area.