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Drug Discovery
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Synthetic Peptide Non-Covalently Transports Cancer Drugs Across the Blood-Brain Barrier
By BiotechDaily International staff writers
Posted on 18 Jun 2014
Cancer researchers have used a novel synthetic peptide to transport chemotherapeutic compounds and other small molecules across the blood-brain barrier and into the brains of mice.
The transport peptide, K16ApoE, comprised sixteen lysine residues and 20 amino acids corresponding to the LDLR (low density lipoprotein receptor)-binding domain of apolipoprotein E (ApoE). Investigators at the Mayo Clinic (Rochester, MN, USA) had demonstrated previously that by mimicking a ligand-receptor system, K16ApoE could deliver three different proteins (beta-galactosidase, IgG, and IgM) in a non-covalent fashion across the blood-brain barrier. To their knowledge this was the first report demonstrating successful delivery of various proteins across the blood-brain barrier that did not involve chemically linking the proteins with a carrier entity.
In the current study, the investigators delivered chemotherapeutics and other agents into the brains of mice either by injecting the carrier peptide and the drugs separately or as a mixture via the femoral vein. A modification of the method comprised injection of K16ApoE pre-mixed with cetuximab, followed by injection of a small-molecule drug.
The investigators reported in the May 21, 2014, online edition of the journal
that seven-of-seven different small molecules were successfully delivered to the brain via K16ApoE. Depending on the injection method, brain uptake was 34–50-fold greater for cisplatin and 54–92-fold greater for methotrexate with K16ApoE than without. Visually intense brain-uptake of the dyes Evans Blue, Light Green SF, and Crocein scarlet was also achieved. Direct intracranial injection of Evans Blue showed locally restricted distribution of the dye in the brain, whereas K16ApoE-mediated intravenous injection resulted in the distribution of the dye throughout the brain.
"We know that some chemotherapeutic agents can kill brain tumor cells when they are outside the brain (as in a laboratory test). But because the agents cannot cross the blood-brain barrier, they are not able to kill brain tumor cells inside the brain. With the peptide carrier, these agents can now get into the brain and potentially kill the tumor cells," said senior author Dr. Robert Jenkins a neurology researcher at the Mayo Clinic.
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37 U.S. Code § 802 - Forfeiture of pay during absence from duty due to disease from intemperate use of alcohol or drugs
A member of the Army, Navy, Air Force, or Marine Corps, on active duty who is absent from his regular duties for a continuous period of more than one day because of disease that is directly caused by and immediately follows his intemperate use of alcoholic liquor or habit-forming drugs is not entitled to pay for the period of that absence. However, a member whose pay is forfeited for more than one month is entitled to $5 for personal expenses for each full month that his pay is forfeited. Determinations of periods and causes of absence under this section shall be made as prescribed by the Secretary concerned, and are final.
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For women who experience the most freedom and comfort in fitted run apparel, the New Balance Komen Go 2 Capri is a classic choice for cooler days or added coverage. It boasts a simple design with soft, stretch fabric and reflective accents. New Balance will donate 5% of MSRP to the Susan G. Komen for the Cure foundation.
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On Saturday, a routine system check caused a nationwide problem for people enrolled in the SNAP, or food stamps program, and using EBT cards.
Many people, including Albany residents, could not use their cards . Some stores including Dollar Tree posted signs outside to alert customers of the inconvenience.
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Implementation Examples: MAP-IT at Work
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Tasks not syncing on iPhone abd iPad
Asked on Oct 28, 2013 - 15:20
Just noticed this is the past two days. I have 2 tasks that are pending today which I can see in Todoist in the Chrome extension, however, on my iPhone and iPad it just says "no tasks for today".
I've tried uninstalling and logging back in on both devices and the tasks don't show up still.
Any ideas?
All responses
Replied on Oct 28, 2013 - 16:26
Hello Andrew,
We're sorry for the inconvenience, we're looking into this right now.
Best regards,
Replied on Oct 28, 2013 - 17:20
This issue should now be fixed. Please resync the data or make a minor change on your task list or log out and back in to see the changes.
Best regards,
Replied on Oct 28, 2013 - 17:29
Thank you, that now works again.


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I did 2 pages. I uploaded both pages separately and then together as a 2 page spread. I hope that's ok! I just decided to purchase the kits today & participate, so I didn't say I was participating sooner.
Thanks for such great products & organizing this great exchange!! I look forward to getting everyone's pages!


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Are you looking for a good looking couple that you can spend time with chatting? Is this you? Then you have totally found the right place. FLING has the most entertaining couples out of other adult personals on the web. The registration is fast and the webpage is easy to navigate through. You will have the chance to create a member profile with pictures of yourself and some information. You may be wondering what information do you need; well you can talk about what you are looking for in a individual and something fun about yourself to develop traffic from promising daters.
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KUWAIT CITY (AP) — Secretary of State John Kerry said Wednesday that he's set no ad hoc deadline for making concrete progress in talks between Israel and the Palestinians that he's continuing this week, but that long before September there needs to be some kind of progress shown.
The U.N. General Assembly, which reconvenes in September, voted overwhelmingly in November to upgrade the Palestinians from U.N. observer to non-voting member state. The Palestinians have said that if attempts at reaching an accord between the two sides fail, they would pursue a strategy of international recognition on their own, which would make finding peace in the decades-long conflict more elusive.
Kerry spoke during a news conference with Kuwait's emir, Sheik Sabah Al Ahmed Al Sabah. Later Wednesday, he was heading to Amman, Jordan, which he will use as a base for diplomacy with Jordanian, Israeli and Palestinian officials. It is Kerry's fifth visit to the region since becoming secretary of state earlier this year.
"The time is getting near where we need to make some judgments. Last time, I was here, I said it's time for leaders to make some hard decisions," Kerry said. "That stands. It is time. Why is it urgent? It's urgent because time is the enemy of a peace process."
"I don't want to trap myself or any of the principals in this with arbitrary — or somewhat ad hoc time limits," Kerry said.
But he added: "Long before September we need to be showing some kind of progress in some way. ... That's why I'm here for this visit and I hope it can be productive."
Kerry has been shuttling between the Israelis and the Palestinians in search of a formula to restart talks. So far, there have been no signs of a breakthrough.
Palestinian President Mahmoud Abbas is being propelled toward a stark choice that could come as soon as next week, define his legacy and set the course for his people in their conflict with Israel. Abbas' aides fear he's being pushed by the U.S. into dropping his conditions for negotiating with Israeli Prime Minister Benjamin Netanyahu
Israeli settlements are at the heart of the heart of the nearly five-year impasse in Mideast peace efforts. The Palestinians say they will not negotiate while Israel continues to construct settlements in territory they seek for a future state. Netanyahu says the fate of the settlements should be resolved in negotiations, and talks should resume immediately without any preconditions. The Palestinians claim the West Bank and east Jerusalem, which were captured by Israel in the 1967 Mideast war, as parts of a future state.
"We come at this carefully. We have been working towards, hopefully an understanding that allows everybody to move forward, notwithstanding the difficulties that people face in the politics of their own countries," he said. "Why am I confident that something can be done? Because I believe peace is understood by them — both of them — to be urgent."
On Syria, Kerry acknowledged that getting a transitional government set up was a "hard lift."
But he painted a dire picture of the alternative to convening an international conference to reach a political resolution to the two-year civil war.
"The people of Syria are suffering ... the prospect a long, continued war, which is very possible, means not only will many, many people die, many more homes will be destroyed, cities be destroyed," he said. "Not only will you have more atrocities, more violations of human rights, even some small evidence here and there of some ethnic cleansing."
"Not only will you have all that, but you may ultimately have complete destruction of the state of Syria so that the army and the institutions will fall apart and you will have a complete sectarian breakdown," he said, "and that becomes far more dangerous for all of the region because it will empower extremists as well as create ongoing sectarian strife" in the region.
Kerry reiterated his called for Iran and the Hezbollah fighters, which are bolstering Assad's forces, to leave Syria — a move he said would make it easier for a political resolution to be reached.


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I kind of love Ray Lewis. I know I know...but still.
Usual gameday attire for me. (This was back in December 2009 when the Saints were killing it)
Go Ravens!
I had totally forgot about those charges until the media drug it out in the last couple of weeks. He was an amazing player to watch


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Bech's Organic Pili Nut Farm will be the largest producers of Organic Pili Nuts in the next 5 years, making them 'THE largest suppliers of organic pili nuts in the world. 200,000+ Pili Trees planted to date. Volcanic Organic Pili nuts are native to the Philippines and are considered a tropical to semi-tropical tree. Almost all parts of the tree are useful commercially. The nut is eaten raw, in which state it has a flavor similar to pumpkin.
When roasted, the pili nut has a flavor similar to almonds.
The shoots are eaten in salad and the fruit pulp is cooked and eaten.
Learn more about the benefits CLICK HERE This will certainly educate you with all the benefits from that the Pili Nuts have to offer, not just as a food, but also in medicines, cosmetics, to name a few, enjoy looking around and learning more.
"The pulp is nutritious and carries as much nutrition as an avocado. The seeds and other parts can be pressed for cooking oil or for use in cosmetics"
The farm is located way up in the highlands at Tablas Island, this is clearly the best climate for the healthy, strong growth of the Organic Pili Nuts. We have access roads all up to the farm and now recently all around the Orchards Phases 3, 4, 5, 6 as well as all the brand new irrigation system we have recently installed.
Climatic and Soil Requirements. Pili thrives best in areas where rainfall is almost evenly distributed throughout the year and in sandy loam soil rich in organic matter and in volcanic soils like it is here at Bech's Organic Pili Nut Farm. The tree is sometimes planted under coconuts, where it has to compete for nutrition and water, but where, in general, they thrive. Soils where volcanic activity has taken place are favorable to the Pili Nut Tree.
Pili nuts come from the Pili tree (Canarium ovatum) Native to the Philippines, the Pili tree is a hardy rain-forest tree that bears a nut with a very hard pointed shell, which houses the creamy melt in your mouth nut, Pili nuts have a rich, buttery flavor, often said to be superior to that of almonds and Macadamia nuts. Few people know about the delicious pili nut, never mind the health and beauty benefits behind it, rapidly being classed as the number one Nutritious nut in the world. Pili nuts are like chocolate melting in your mouth effect it has on your taste buds, and the long term health benefits it has on your body.
The secret to success with the Pili Nut trees is in the Organic volcanic soils that they grow the trees in, all of our trees are given natural organic feeds and supplements 60% of the water is from the rain, the rest is supplied via our irrigation system, creeks and rivers around the farm, all natural, non polluted, pure spring water.
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Discover Adionomy, Your Online Radio Advertising Campaign, Fast, Easy and Custom-Made!
Claus Terhoeven aka Nic Chagall is best know one half of the German trance duo Cosmic Gate, though more recenly has found success as a solo artist, with a number of successful releases on High Contrast Recordings, most notably of which is the highly acclaimed vocal anthem "What You Need". In his solo guise "Nic" has also remixed a number of other artists tracks, most recently of which is his beautifully techy remix of Filo & Peri's smash hit "Anthem".
0 played on Radionomy


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Where am I?
Caps, Gowns, Class Rings, Announcements
All students participating in Commencement are required to wear appropriate academic attire.
If you did not pre-order your cap and gown, you may purchase one at the Bookstore beginning April 22 until May 16th @ 2:00pm. Pre-ordered attire will be available beginning May 6th in the Bookstore. Cap and gowns are available on main campus only.
You may order announcements, class rings and other commencement products from Jostens directly. Please note that custom announcements require at least 3 weeks for delivery. Class rings and generic announcements may be ordered at any time from Jostens directly. Caps and gowns will be available for purchase in the bookstore through May 16th.
Please note hours of the bookstore:
Monday through Thursday: 9:00am - 6:00pm; Friday: 9:00am - 2:00pm Closed Saturday and Sunday
The Bookstore will be open the day of commencement for emergency purchases.
Additional Information:
Undergraduate tassels are to be worn on the right side of the cap until the announcement is made at the ceremony to formally move the tassels to the left side. Graduate tassels are worn on the left side at all times.
The Office of Academic Affairs will notify undergraduate students who have earned graduation (Latin) honors. Latin Honors recipients are eligible to wear honor cords, which will be provided by the University, with their gowns.
The honor cords will be distributed at the Honors Convocation in early May 2014. If someone is unable to attend the Honors Convocation, the cords may be picked up from the Registrar's office in Ryan 205. Master degree candidates do not wear honor cords.
Graduate and Undergraduate candidates are invited to wear the stole and pins that they have received at the Convocation Ceremonies held throughout their years at Fontbonne University.


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One police department is getting national recognition for its support of the troops.
The Sheffield Police Department has been named a "patriotic employer" three times in the last four years.
It is an award Chief Greg Ray describes as bittersweet.
"It is a double edged sword because we are taking some of our best officers and sending them to the conflicts all throughout, and we also have a home front to protect, so it's kind of a catch-22 situation, but we realize this has to happen," he said.
Two banners hang in the entryway at the Sheffield Police Department, symbolizing their support for two of their men currently on deployments.
Covering their positions on the home front isn't always easy.
"Sometimes it's a burden when you don't have enough officers to cover shifts and being gone for a year at a time, it's tough," said Ray. "We always hate to see that officer leave, but we do realize what they're doing."
The Department of Defense has recognized the Sheffield Police Department as a patriotic employer. The award honors the sacrifices made by employers who support our nation's guard and reserve service members.
"We certainly stand behind every officer that's ever been. We're honored to have officers from our department protect our country," said Ray.
He said he admires his officers for their commitment to protecting our country.
"It's hard to imagine being a two front soldier, being an officer, and then going off in the military and fighting for your country, and then coming back and being a law enforcement officer. I admire people like that," he said.
One of the two soldiers, Rodney Rippey, just returned home from his deployment on Monday with the 167th unit in Cullman.
Copyright 2013 WAFF. All rights reserved.
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Learn more about the five boroughs that make up New York City with our complete guide.
Discover what to do, where to stay and what to see in New York City with our planning tool.
NYC is the place for inquisitive minds looking for new things to see, hear, taste and learn.
Enjoy The Nutcracker, the Times Square New Year's Eve Ball Drop, the Orchid Show and more.
Download your free copy or order a guide online today.
Wireless Internet is available at locations throughout NYC—including many parks and libraries.
Get tips, maps and everything else you'll need during your stay.
These NYC-centric mobile apps put the City at your fingertips.
Off-Broadway Week: Get 2-for-1 tickets to this diverse roster of shows September 29 – October 12
Special dining offers, exclusively on Sunday.
Hotel deals to make you fall for NYC.
Fatty 'Cue is a play on Zak Pelaccio's Fatty Crab restaurants, here serving barbecue with Southeast Asian accents. Succulent fat does come into play with the flavorful meats, such as red curry–rubbed duck and lamb shoulder with goat-milk yogurt, garlic and Vietnamese mint. It's messy, just as barbecue should be, and piles of napkins are provided. Bright, spicy condiments and cocktails infused with smoked grapefruit, smoked pineapple and Thai basil display creative touches.


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While Paramore experienced some dark days after Josh Farro and Zac Farro left the band in 2010, frontwoman Hayley Williams says that the brothers' departure helped inspire the band's songwriting process for their upcoming self-titled album, due on April 9.
"Obviously our band has just been through a lot and it was kind of the perfect time to write this record," Williams tells Billboard in a video interview. "I feel like we grew up quite a bit since from the time we put out [2009's] Brand New Eyes to this record, this is really the story of the last three years of our lives. I'm just so proud of it."
Williams adds that fans can expect the album to feature a fair amount of musical experimentation. "I just feel like the record has so many different sides of our band," she reveals. "We like so many different genres, and somehow it all worked in our favor this time around. It really is hard to put a finger on what this record sounds like."
Copyright 2013 ABC News Radio


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These days, most couples want to find out the sex of their unborn baby, but Michael Buble says he and his pregnant wife have differing opinions on the subject...and unfortunately, she's overruled him.
Speaking to Australia's Kyle and Jackie O show , Michael said that he and his wife Luisana went for a sonogram, but they couldn't see the sex of the baby because "it had its legs crossed and wouldn't cooperate." The singer predicts that they'll find out very soon, but it's entirely against his will.
"The truth is, I don't wanna know," he said. "But it turns out that my wife is the boss of everything, so she decided what I would find out and what I wouldn't. I didn't have a choice!"
Plus, finding out the sex of the baby won't do anything to assuage his fears of first-time fatherhood. Michael told the radio show, "It's the weirdest thing. I'm scared, I don't know what I'm doing. My friends are all laughing at me, telling me I'm never gonna sleep again and there's gonna be poop everywhere!" But, Michael says, "The truth is, I think the good stuff is gonna outweigh the bad."
Michael also spoke a bit about Reese Witherspoon , with whom he duets on his upcoming album To Be Loved. He says the two met a while back and liked each other, and he was knocked out by her singing in the movie Walk the Line. He asked her to record the Sinatra tune "Somethin' Stupid" with him and was thrilled when she agreed.
"I called her the other day and told her that she was the icing on the cake...the cherry on top for this record, she did such a great job," revealed Michael. To Be Loved goes on sale April 23.
Copyright 2013 ABC News Radio


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You'll definitely have to check a couple heartbeats when you walk into the room wearing the Adult Nurse Nicky Plus Size Costume. This costume will bring some new life to your Halloween night. The outfit comes with a white dress with buttons on the front and red lacing on the sides. The dress has an included garter belt that has the medical symbol across the bottom of it. A nurses headpiece is included too with the same symbol on it, just as a nurse would typically wear in a hospital. A toy stethoscope is also included but the costume isn't complete until you purchase some stockings, gloves, and shoes from our accessories section. You can bet that blood pressure will be very high when you show up in this incredibly sexy costume.
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Task Force, Inc., hails Senate passage of federal hate crimes legislation
Roberta Sklar, Communications Director
(Office) 646.358.1465
(Cell) 917.704.6358
Vote clearly shows that U.S. rejects all forms of hate violence, including bias-motivated crimes against lesbian, gay, bisexual and transgender people
First time a bill extending protections to transgender people has passed both houses of Congress
WASHINGTON, Sept. 27 — The National Gay and Lesbian Task Force, Inc., hails today's landmark passage of a gay and transgender-inclusive federal hate crimes measure, included as an amendment to the Department of Defense reauthorization bill. The amendment, introduced by Sens. Edward Kennedy (D-Mass.) and Gordon Smith (R-Ore.), passed by a 60–39 cloture vote, which ended debate and sent the bill to the floor where it was approved by a voice vote.
Statement by Matt Foreman, Executive Director
National Gay and Lesbian Task Force, Inc.
"At long last, Congress is putting a bill on the president's desk to condemn and respond to violent crimes based on hatred of a person's sexual orientation, gender, gender identity or disability. Laws ultimately reflect a nation's values and today's vote says that America rejects all forms of hate violence, including bias-motivated crimes against lesbian, gay, bisexual and transgender people. This victory is all the more sweet given the right wing's hysterical, defamatory and lying campaign against it.
"We are deeply disappointed by President Bush's past statements that he would veto hate crimes legislation. The president has also threatened to veto the larger Department of Defense reauthorization bill to which this measure is attached. We call upon the president to work with — rather than oppose — the Congress, the overwhelming majority of the public and national and local law enforcement leaders in enacting this important legislation.
"Violence against lesbian, gay, bisexual and transgender people has escalated over the past 25 years. Since establishing our groundbreaking Anti-Violence Project in 1982, we have been working to get the federal government to take a stand against this epidemic. Until today, sadly, little progress has been made in the 17 years since Congress passed the Hate Crimes Statistics Act, because right-wing forces would rather see hate crimes against lesbian, gay, bisexual and transgender people ignored than have the words 'sexual orientation' or 'gender identity' appear alongside other protected classes in federal law.
"We particularly thank Sens. Edward Kennedy and Gordon Smith for their leadership and commitment to the passage of this legislation. We also want to recognize those courageous senators who stood in support of this vital legislation despite immense political pressure from anti-gay forces."
The Local Law Enforcement Hate Crimes Prevention Act of 2007 (LLEHCPA) extends federal authority for investigation and prosecution of hate violence to crimes based on the victim's actual or perceived sexual orientation, gender, gender identity or disability. Current federal hate crimes law covers crimes motivated by race, religion and national origin. LLEHCPA also removes the existing limitation on federal involvement that a victim of a bias-motivated crime must have been attacked because the victim was engaged in a specific federally protected activity such as serving on a jury or attending public school. The Department of Justice will now have the authority to provide assistance to local law enforcement agencies in addressing all forms of hate violence.
Lesbian, gay, bisexual and transgender people are disproportionately affected by hate violence. In fact, lesbian, gay and bisexual people are more likely to be victims of hate-motivated physical assaults than other minorities, including African Americans, Jews and Muslims. According to the FBI, 14 percent of hate crime victims in 2005 were victims of crimes motivated by hatred of lesbian, gay or bisexual people. Moreover, reports produced by the National Gay and Lesbian Task Force (1984–1993) and the National Coalition of Anti-Violence Programs (1994–present) have documented more than 35,000 anti-LGBT crimes over the last 22 years. It is important to note that these statistics are based on reports from only a handful of local LGBT crime victim assistance agencies.
The version of the hate crimes bill passed today includes crimes based on a victim's actual or perceived gender identity. The clear inclusion of transgender people in hate crimes laws is especially important because violence against transgender people is widespread, largely underreported, and disproportionately greater than the number of transgender people in society. In 2005, the National Coalition of Anti-Violence Programs reported that 11 percent of the 2,306 victims of reported hate crimes identified as transgender.
The Task Force has been a leader in efforts to secure an effective and full government response to hate crimes against lesbian, gay, bisexual and transgender individuals, beginning with the launch of its groundbreaking anti-violence project in 1982.
Additional resources for media
Learn more about the Task Force's groundbreaking and longtime work to secure hate crimes protections for lesbian, gay, bisexual and transgender people.
The National Gay and Lesbian Task Force, Inc. ("NGLTF, Inc."), founded in 1974, works to build the grassroots political power of the LGBT community to win complete equality. We do this through direct and grassroots lobbying to defeat anti-LGBT ballot initiatives and legislation and pass pro-LGBT legislation and other measures. We also analyze and report on the positions of candidates for public office on issues of importance to the LGBT community. NGLTF, Inc., is a 501(c)(4) nonprofit corporation incorporated in New York. Contributions to NGLTF, Inc., are not tax-deductible.
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- Bruno Giussani
- Lausanne
- Switzerland
European Director, TED
This conversation is closed.
Which relevant/important events currently unfolding around the world are being ignored by the media? Why are they relevant?
Open a newspaper or watch a newscast, and along with a couple of important news (say, Egypt and Tunisia) and a couple of surprising and insightful stories, you will read or hear a lot of irrelevant stuff. Yet world-changing and life-altering events are happening all the time around the world - just not where the media are focusing their lenses (I'm not suggesting active censorship here - just a structural problem in the way "news" is identified, selected and distributed). What are the events currently unfolding, anywhere in the world, of any kind, that are 1) underreported 2) regionally or globally truly relevant 3) may have a broad impact and 4) people should know about?
Showing single comment thread. View the full conversation.
Mar 4 2011: .
The rapid emergence of Africa as an economic powerhouse is definitely an underreported story.
Sub-Saharan Africa's middle class is now bigger than that of much hyped economic wonder India. And it already has more purchasing power. Africa's stock exchanges are the world's best performing, and they are so consistently, not just temporarily or by some trend in commodities.
The rise of Africa will stun everybody -- especially because it is so underreported.
And the (Western) media cannot accept that this rise comes from Africa itself. In a persistently colonial logic, they continue to attribute this rise (if reported at all), to some "outside" force: be it China which is investing, or the diaspora which is coming back, or some anonymous market force coming from the West. All these external forces pale compared to Africa's own dynamism and its growth spurred by its own rising class of investors and its hyper-globalised middle-class.
Because of our own prejudice against Africa (and our wish to "help these poor people" via our aid industry), we will all be surprised and stunned, pretty soon.
Jing CaoMar 8 2011: Hey Laurens, I couldn't agree with you more. I was already quite surprised and stunned by Africa during my short stay there last year, and yes I have the miserably poor media coverage to thank.
First of all, I've met some of the most creative and resourceful entrepreneurs and engineer who have developed effective solutions and products, with virtually very little cost. Sometimes it's even painful to admit something that cheap actually does work.
Second I'm amazed by the prevalence of mobile phones, and how many things they're capable to do, all using the simplest models. SMS, facebook, even mobile banking is already incorporated into people's daily lives for quite some while.
Of course the emergence of Africa is by nature complicated. I certainly don't buy into those prototype stories anymore. We need to hear more voices about the exciting developments come from within.
Mar 9 2011: Hi Jing Cao, I agree: we need to get rid of prototype stories.
I exaggerated in my view on Africa, just to give an anti-dote to the eternal "Africa = misery" line of reporting.
But as you probably know all too well: Africa is dynamic because it blends very modern things rapidly with traditional structures.
So lots of problems do persist, but on many other fronts they are really becoming very modern.
The example of the mobile phone is strong: here in Europe we have none of the things they do in Africa with a simple phone. If only the internet-connections could catch up, that revolution would expand even faster.
Mar 10 2011: Totally agree. Huge emerging story, which I've seen up close recently. See Feb. 28 report by American Enterprise Institute demographer. It predicts that the largest share of the increase in the world labor pool next 20 years will be in Africa. In the last 20 years, the big contributors were India and China. Political and social implications of this prediction are substantial. See also my contribution above on how we can bring slow-motion stories like this to light.
Showing single comment thread. View the full conversation.


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To understand the depth of the Republican dilemma that continues to brew in Washington, you only needed to listen to two voices last week.
One belonged to New Jersey Gov. Chris Christie. The primal scream he aimed at his fellow Republicans in the 112th Congress, who on their final day refused to take up a $60 billion relief bill for Hurricane Sandy victims, rumbled across the right-left spectrum of cable TV news.
Most outlets focused on Christie's criticism of John Boehner. The House speaker was to face re-election by his GOP caucus the next day. But the New Jersey governor dropped large hints that his real target was the dominating right wing of the House GOP caucus, peopled primarily by Southern conservatives.
"New Jersey and New Yorkers are tired of being treated as second-class citizens," Christie said. "New Jersey deserves better than the duplicity we saw displayed last night."
"[The bill] just could not overcome the toxic internal politics of the House majority," the governor said. Christie was asked to identify the culprits. "They know who they are," he said.
On that same Wednesday, only a few hours earlier, U.S. Rep. Tom Price, the Republican from Roswell, had dialed into a radio talk show in Washington. The topic was the House vote on the "fiscal cliff" agreement, and Price did more than hint at the regional split in his caucus.
"If you look at the votes that were 'yes' on the Republican side – there were 85 of them. Seventy of them come from blue states," Price said. Nearly 90 percent of House Republicans from the South and border states voted against the Senate measure that was produced by negotiations between Minority Leader Mitch McConnell, R-Ky., and Vice President Joe Biden.
A similar percentage of Northeastern Republicans (far fewer in raw numbers) voted yes.
"I think this is a red-state, blue-state issue," Price said. "It's a different conversation that we need to have within our own conference as we move forward."
When the time came, Price would endorse Boehner's re-election. But he was clearly dangling himself as rallying point for his caucus' most conservative members.
Price ended the interview with this thought: "I think we need red-state representation in both our leadership as well as the organizing committees that we have." Boehner, of course, is from Ohio. House Majority Leader Eric Cantor represents Virginia, which has slipped into swing-state status.
Disregard the fact that Price, despite his years in the Georgia General Assembly, is a Michigan import. The Roswell congressman was declaring the need for House Republican leaders who are not just more conservative, but more Southern as well.
This is an important point, because Republicans have nearly maxed out in the South. Future gains will come from elsewhere, in states with districts less solidly Republican. So Price's argument could be interpreted as one of consolidation of the House GOP majority, not expansion.
Larry Sabato, the University of Virginia political scientist, was among the first to spot last week's regional split. Price is far from alone, he said.
"To get a bunch of Republicans from the Northeast or even some of the urban-suburban Midwestern states is to guarantee that the moderates have more weight. They don't want that," Sabato said. "They would prefer to have a smaller majority. I think some would prefer to be in the minority."
Remember that former U.S. Sen. Jim DeMint of South Carolina, who just left to head the Heritage Foundation, famously declared that he'd rather have a group of committed conservatives in the Senate than a majority.
It is a peculiarly Southern trait, as many of our ancestors can attest, to prefer principle – whether right or wrong – over what might be considered natural self-interest. "There's nothing in the law or Constitution that says a party has to win," Sabato said.
On Friday, a chastened but re-elected Boehner put the first of three Hurricane Sandy aid bills up for a vote before the newly seated 113th Congress. It passed easily, 354 to 67. All votes in opposition were cast by Republicans. Thirty-one came from the Deep South, including five from Georgia. Price's vote was among them.
- By Jim Galloway, Political Insider
For instant updates, follow me on Twitter, or connect with me on Facebook.
January 5th, 2013
9:21 am
In other words, southern GOPers are prejudiced. Big surprise!
Let's see, they don't like civil rights for African Americans, they don't like civil rights for the LGBT community, they don't like privacy rights for women, they don't like immigrants or their children, they don't like non-GOPers, and they don't like non-right-wing radicals. That doesn't sound so much like a political party as it does a hate group.
If Boehner was a smart man he should really consider marginalizing the southern GOP delegation into nothingness. They are a perpetual humiliation to the party and the country. Just look at how these people (southern GOPers) run their own states and tell me they have a plan for the nation. They are clueless and devoid of any intellectual foundations upon which to build a plan for America's future other than handing the country over to the super-wealthy and claiming that is how capitalism works.
January 5th, 2013
9:25 am
Where is the free market? If you want to live in certain areas, run the insurance calculations and pay the preminums. If you live in Kansas or Oklahoma and a tornado comes through, you don't have to worry about hearing, "I'm from the government and I'm hear to help.
January 5th, 2013
9:37 am
I wonder why Dr Price and his fellow clown brigade can't see the problems they will face as the Republican Party devolves to no more than a southern regional party.
January 5th, 2013
9:42 am
Lets see the lowest education rates are dominated by southern states. How else do you get people to vote against their own interests.
January 5th, 2013
9:42 am
Happy New Year!
I thought the civil war was over 148 years ago. The south is still fighting in hopes of it rising again. This is not good for America. Take a look at the southern states that are run by the GOP and view the poverty and education levels. It will speak volumes to even the most casual observer.
In 2013, let's hope the people will become educated and begin to vote these LOSERS out of office.
So speaks HOT DOG
January 5th, 2013
9:48 am
Eli, sadly you are right. As a moderate Republican, I have been deserted by my party in the South. The GOP in the north is the last vestige of the Republican Party I once knew and supported. It is frightening that these southern Republicans keep winning elections. I guess that means that a majority of southerners feel the same way. You can also add to your list that they don't believe in science.
January 5th, 2013
9:52 am
The economy of totally GOP controlled Georgia vs the US in general, will prove, over time, the lack of leadership from the Republican Party. It starts "big time" with opting out of the Affordable Health Care provision to cover lower income Georgians via medicaid.
That will prove to be the worst decision for growth and quality of life for Georgians ever made.
Not only will the lower class suffer, but due to the exodus of Doctors, so will all Georgians.
Hopefully, that will jump start the anti GOP movement and bury this 19th century party once and for all.
January 5th, 2013
9:53 am
Wow, the Republicans aren't lock step talking point stooges, like we are. Let's make big hay about it.
Can I get a duh?
January 5th, 2013
9:53 am
These third and fourth generation Johnny Rebs will once again unite the country against them because of their low morals and misguided value systems…. Blue state vs Red State ???? It is more like the educated vs the under educated..
January 5th, 2013
9:57 am
We lost Virginia and Florida and here's what Lib Galloway's analysis discovers -
This is an important point, because Republicans have nearly maxed out in the South.
Attention, libbies – The Repugs ran a flip flopping northeastern big government rich guy who's own health care plan was the model for obozocare. How do we improve upon this? Lure nasty pelosi over to our side?
January 5th, 2013
9:59 am
As Christie pointed out, this is also a "makers versus takers" split. The Northeastern states with moderate Republican representatives give more in taxes to the federals government than they get back; the hard-red Southern states get more than they contribute. Demonizing the very fiscal basis for Georgia's survival cannot be a good strategy for Price and his ilk.
January 5th, 2013
9:59 am
The south/north split is an interesting insight. Red southern states are the biggest takers of aid from the Federal government, and yet the majority of inhabitants of red states insist on cutting Federal government spending! Blue states contribute more money to the Federal government than they take. That's why Christie and other blue state Republicans were so appalled by those red state Republicans who voted against aid to NY and NJ. Blue states are Federal government givers. Southern states are Federal government takers. That's why the succession petition after Obama was re-elected was so precious.
January 5th, 2013
10:01 am
Please register to vote democrats/independents, run someone against every Republican, remember Allen West got defeated in a Republican district. I think he and his wealthy backers spent about 17.3 million to his conservative democrat opponent's 3.4 million. If you will go to c-span, you can see what the republican in your district is saying and voting on to see if he is representing you or his wealthy supporters. If you have less than a million dollars in the bank, you had better try to get together with other working people and vote someone in who will watch out for you , your family. do not be mislead by mouthpieces who are worth millions. Run for office yourself, get to know and register every voter in your district. Where else can you get a job where you only work about 130 days, get paid 174.000, good healthcare, retirement paid for by taxpayers, employees to write up laws, take care of your voters, free trips home every weekend from Thur till Mon afternoon, make contacts to make millions after you leave congress.
as lobbyist/other jobs.
January 5th, 2013
10:01 am
Living in a county that was wrecked by tornadoes in April 2011, and who received a large amount of assistance from FEMA, to find my Representative, Mr. Price, voting No to aid to NJ/NY leaves me angry and wondering if he'll vote No for my county next time…or does he only do that for "the Yankees"? Pathetic…
January 5th, 2013
10:06 am
."Palace Intrigue". (Price) WWMAS? What would marie antoinette say? "If they have no hurricane relief, then let them seek earthquake (relief)."
January 5th, 2013
10:12 am
The Price is right! There ought to be someone from the south in the House leadership, if for no other reasons than the greater ability to broker deals among factions when the going gets tough and ensure that their point of view is heard at the start of policy discussions.
Let's also see this for what it is — an opportunity. Southern conservatives don't understand the degree to which their social policies have eviscerated Republican strength in the West, which leans more Libertarian and the Northeast, where the prevailing outlook is one of Main Line rather than Evangelical Christianity.
There needs to be some meeting of the minds at the very least on how to characterize and describe social issues so that entire groups don't continue run from the Republican brand. I would suggest that the Southern home base isn't as secure over the medium term as many Southern Republicans think that it is, so this discussion will not be just idle chatter here in Atlanta.
January 5th, 2013
10:13 am
Funny how all of these comments run along lines of prejudice, bias, north v. south, etc. Could it just be that the southern GOP was against all of the pork spending that was tacked onto the Sandy Relief Bill, as in 1.2 billion for Alaska fisheries (gee, didn't realize Sandy went that far West), a new roof for the Smithsonian (gee again) and other such local district freebies. The bill may have been titled Relief for Sandy, but if you actually took the time to look at the bill and all the amendments and riders, it was mostly a poorly-disguised stimulus bill. As for me, guess I'm one of those mean-spirited conservatives. If you are going to live near a coast, where hurricanes and storms are known to happen, it's your choice and you should carry hurricane insurance, flood insurance, whatever. You choose to live there so accept the consequences and stop looking for the gov't to bail you out.
January 5th, 2013
10:16 am
These are the states that get the most federal money.
1) Alaska- Repug, but also under 3 foot of ice.
Federal spending per capita net of income taxes: $15,197
Total federal spending per capita: $17,762
Federal income taxes per capita: $2,565
2)Virginia- Lib
Federal spending per capita net of income taxes: $14,201
Total federal spending per capita: $17,008
Federal income taxes per capita: $2,807
3) Maryland- total babbling lib
Federal spending per capita net of income taxes: $13,723
Total federal spending per capita: $16,673
Federal income taxes per capita: $2,950
4) Hawaii- nice place but ate up with liberals
Federal spending per capita net of income taxes: $13,709
Total federal spending per capita: $15,331
Federal income taxes per capita: $1,622
5) New Mexico- lib
Federal spending per capita net of income taxes: $12,399
Total federal spending per capita: $13,578
Federal income taxes per capita: $1,179
Go see for yourself, liars -
January 5th, 2013
10:16 am
Those who don't study history are doomed to repeat it. The South was the original third world of the U.S.(particularily after the Civil War), and still is. It operates like any other banana republic, with an ignorant, and impoverished populace, ruled by a corrupt governments.
January 5th, 2013
10:17 am
FEMA would not be broke right now if they refused to help the thousands in Georgia, and the many GOP controlled counties, swamped by the September 2009 Floods
January 5th, 2013
10:21 am
Most of the military bases are in the south, which accounts for the south getting most of the largess from the government. Libs love to point out how the southern states get back more than they put in, but never take into account the federal government not only places their military bases here, they own large tracts of land that generates no tax revenue, i.e. Chattahoochee National Forest, Okafanookee Swamp, Piedmont National Forest, etc.
Obviously there is nothing scenic or worth Federal Preservation efforts in NJ or Ohio.
January 5th, 2013
10:22 am
The south, is, and for the foreseeable future, will be a region that prides itself on independence from intrusion of a federalist government, and the pursuit of self determination. I would point out that same philosophy is evident in the northwest mountain states, and the southern border states with the exception of California.
Now do I think the House should have voted to support the Senate bill? Of course. Do I see most of the reps ( mine included)that voted against the bill as demogouging, self preserving , scoundrels? Yes.
That does not mean I think the philosophy is wrong, just the method and messengers carrying it out. You will little sympathy from me on the issues some have raised here, but I don't embrace the tactics some use to change them either. Don't be so quick judge the south, and make no mistake, it has already risen. We have made mistakes and changes, as we continue to do, but I hope I NEVER live to see the day we blindly follow blow hards like Christie that would have the house pass such a pork laden bill that was bad for the country. We will vote again in two years, and I think then the moderate majority will call to task these that choose themselves over their district and country.
January 5th, 2013
10:25 am
Bad news for the Southern "conservatives." The era of the domination of the white man is over.
January 5th, 2013
10:32 am
@Aesop's Fables – 2 statements made and neither makes a lick of sense. –
Yes republican politicians in Washington are for the most part in lock step. They vote against anything the African American President is in favor of even if they were the ones who originally thought of it.
There were 10 clowns and 1 statesmen running for the republican nomination for president. The reason Romney won was because of the extreme right wing politics, or down right idiocy of 9 the other 10. Buddy Roamer was by far the best choice because he would not take campaign donations over $100.00 and would have been a moderate republican president that might have been able to get something done, but y'all ignored him and nominated the Mormon venture capitalist with the conscience of a gnat, who couldn't keep his foot out of his mouth or hold a consistent view on any given issue.
Who are the morons?
January 5th, 2013
10:40 am
riponem – Did you read the blog article^^? Lib Galloway says the whole Repug establishment is in danger of extinction if we don't all become fat northeastern backstabbing larders like christie.
And if you think Romney was "extreme right wing" maybe you should pull your head out of cnn's kiester.
January 5th, 2013
10:41 am
January 5th, 2013
10:16 am
Those who don't study history are doomed to repeat it. The South was the original third world of the U.S.(particularily after the Civil War), and still is. It operates like any other banana republic, with an ignorant, and impoverished populace, ruled by a corrupt governments.
And prior to the civil war the south was the wealthiest, best educated part of the nation. In 1860, Mississippi was the wealthiest state in the nation,
January 5th, 2013
10:42 am
Eddie Hall and "a dad" have it exactly right. It's also amusing to see the usual hyper partisans on here spouting their intolerant stereotypes against the south and republicans while at the same time trying to act like they and their party is superior. Eli's first comment is that GOP southerners are prejudiced and are against African Americans' civil rights. What a hoot. Democrats were the ones who denied blacks their rights for decades. Some of these posters need a history lesson.
January 5th, 2013
10:45 am
If I wanted to define impoverished banana republics, I would look no further than detroit, chicago, oakland, trenton, newark and philadelphia.
January 5th, 2013
10:49 am
[...] Christie in his protest over the House not voting Tuesday night on an emergency bill for …A North-South split surfaces among Republicans in CongressAtlanta Journal Constitution (blog)McManus: The worst job in CongressLos Angeles TimesWhite House [...]
January 5th, 2013
11:07 am
What riponem said.
I lived in Louisiana during the time when Buddy Roemer was governor there. He would have made a great President – conservative, but not whacko like most of the other candidates.
But that also meant he couldn't win the nomination, since the Republican base is full of people like many of the posters here.
January 5th, 2013
11:07 am
[...] Christie in his protest over the House not voting Tuesday night on an emergency bill for …A North-South split surfaces among Republicans in CongressAtlanta Journal Constitution (blog)McManus: The worst job in CongressLos Angeles TimesWhite House [...]
January 5th, 2013
11:11 am
Eli is right, unfortunately. Not all Georgians/Southerners are Republican. I do not like the rest of the country thinking all Georgians agree with the Georgia Republicans.
January 5th, 2013
11:16 am
An excellent, astute analysis. I urge readers to see the film, "Lincoln," currently playing in theatres in the Atlanta area.
From my blog "Mary Elizabeth Sings," post entitled, "Finding One's Inner Spirit," January 14, 2011:
"The President (Obama) also spoke of the need for an 'expansion of our moral imaginations' in order to create a more empathetic nation. I thought of how United States General Ulysses S. Grant had shown, in victory, magnanimous empathy to his counterpart, Confederate General Robert E. Lee. Grant had said that he was saddened by the valiant Lee's fate in his surrender because Lee had waged such a courageous battle for his cause, even though that cause 'was one of the worst for which men have ever fought and for which there was the least excuse.' In other words, Grant had exercised an 'expansion of his moral imagination' to place himself, mentally and spiritually, in his former enemy's consciousness. Grant had been able to identify with Lee's sensibilities as well as with all Southerners' sensibilities, and thus, he had been able to be generous not only toward Lee in their private meeting at the end of the Civil War, but toward all Southerners in their reunification with the Union.
In order to know the depths of our unique beings, we must be able to exercise imagination that transcends the temporal. For example, I happened to have been born a white female in south Georgia in the early 1940s when Jim Crow was alive and well in the segregated South. As I experienced an 'expansion of my moral imagination' as an adolescent, I empathized with African-Americans who happened to have been born black in south Georgia in the middle of the twentieth century. Knowing that we are all spiritually equal, I could not abide the superior perceptions that most white Southerners displayed toward black people. Something in my 'moral imagination' told me that I was born a white Southerner, in the middle of the 20th century, simply by an act of fate or chance."
It is past time for the South and Southerners to elevate their collective consciousness beyond simple regional identification into something much more humane and truly spiritual, even in politics. If Eleanor Roosevelt had the wherewithal to make that more humane vision toward all humanity become manifest in reallity, then so can the South and its people.
January 5th, 2013
11:17 am
Who cares about a split? Congress needs to get to work. I see where they are talking about across-the-board cuts. Where are the salary cuts?
January 5th, 2013
11:30 am
I say if the south is so bad why not stay up north when you retire instead of stinking up the south with all your "the way we did it in (where ever) crap. We will be fine without you. And most of the federal money that comes south is to support all the welfare and lazy libs on foodstamps (white and black and brown).
January 5th, 2013
11:33 am
lynnie Gal The red state solons want to cut the govt spending even for their own states because they do not want to fund programs for the poor, the elderly, the children. There are both black and white poor and elderly and needy but the repubs do not care about them- never have. Of course the same solons also claim to be evangelicals. Amazing no?
January 5th, 2013
11:34 am
td @ 10:41 a.m.–actually, td is largely accurate about the wealth of pre-Civil War South. But it was a wealth that did not count slaves as people for statistical purposes but which did count them as valuable property in value. Plus the plantation economy of the South could only continue to amass wealth for its rulers so long as they had a source of cheap labor–i.e. slave labor. The Civil War ended that and the South has never fully recovered even with various contrivances to continue the availability of cheap labor. What do you propose? Surely not that we return slavery?
January 5th, 2013
11:52 am
"Those who don't study history are doomed to repeat it. The South was the original third world of the U.S.(particularily after the Civil War), and still is. It operates like any other banana republic, with an ignorant, and impoverished populace, ruled by a corrupt governments."
You obviously will never be happy here. Why not move to the northern climes where all is well? You might strongly consider tranquil locales such as Chicago, Flint or Detroit?
January 5th, 2013
11:55 am
I am a born and raised Southerner. And I HATE the political climate. I have a good job/career, friends, family etc that have kept me here. But I am approaching retirement and look forward to fleeing the unenlightened (even ignorant) political viewpoints that abound across the South.
January 5th, 2013
11:57 am
Yes, Yuzeyurbrane, td and you are right. But what is the point of pointing out how rich Mississippi once was? It's like talking about how great a football team was in 1948! Has nothing to do with today. And the fact is used mostly by those hearkening back for the "good old days", when the white people had all the poitical and economic power in the South. I, for one, am glad those days are over.
January 5th, 2013
12:06 pm
January 5th, 2013
11:34 am
You and other progressives and not taking into consideration the entire picture. You are saying it is all about wages but do not look at expenses. It cost twice as much to live in NY or CA then it does to live in Georgia. Add to that the differences in taxes you pay and there is a huge difference. NY and CA have a 10% tax rate and in GA a 6%. If you live in NYC then you add another 3% taxes. I have a niece that lives in NYC and pays $1,600 per month for a 720 square foot flat. She would be paying about $600 per month for the same space here.
A $30,000 per year job in Georgia give a person the same buying power as a $60,000 per year job in NYC.
January 5th, 2013
12:09 pm
January 5th, 2013
11:34 am
Just one more point. I have a retired couple from MI that come and rent my condo in PCB for the past three winters. We charge them $900 per month and they told us that it is cheaper for them to rent our condo then to heat their house during JAN, FEB and March.
January 5th, 2013
12:12 pm
January 5th, 2013
11:57 am
" when the white people had all the poitical and economic power in the South"
And let us be brutally honest for a moment. Do white people really have any less political and economic power today in the South?
January 5th, 2013
12:13 pm
@Aesop's Fables and other Lib Economic Theories
January 5th, 2013
9:57 am
And your infantile rants represent deeply held philosophy of deep red state Republican voters? You see nothing wrong with that? You need help.
January 5th, 2013
12:13 pm
This is not race this is a bout paying your bills every month so you do not run into trouble.
January 5th, 2013
12:16 pm
td–Tell me where the $600 per month apt. rent is? I agree with your general pt. that it costs more to live in some parts of NY and Calif. than to live in Georgia. I think your statement that it costs twice as much is probably not accurate but would defer to any reliable statistical source on that point. I lived up North for quite awhile and found some things to cost more, some to be the same, and some cost less. Foe example, real estate tended to cost more, groceries were about the same, and museums and other cultural activities were less.
January 5th, 2013
12:20 pm
And prior to the civil war the south was the wealthiest, best educated part of the nation. In 1860, Mississippi was the wealthiest state in the nation
TD, could that have something to do with not having to pay labor costs?
January 5th, 2013
12:21 pm
The Civil War, translation the soutnerners Rich Man's War.
January 5th, 2013
12:22 pm
Wow! I had not realized so many people who live here in the South are so unhappy here. Please feel free to go back to whatever worker's paradise you came from. Your sweeping and hate-filled generalizations about the South are demonstration that you are the result of left wing inbreeding or you simply don't have an assortment of southern friends! We are a diverse group. Many, maybe most of us, are fiscal conservatives, who believe in the advantages of personal responsibility, work ethic, family (of all kinds), and thrift. Some folks, as with some liberals here, take these positions to an extreme and fold in religion or "morality" in the mix.
No one in Congress should have voted for a 50+ billion dollar expenditure without a lot of review, not even the most spend happy Dem. That's simply irresponsible behavior. Breaking it up and quickly approving the clearly good parts is a reasonable approach, particularly if further votes are timely. This is more critical in view of the debt ceiling debate about to happen.
You say we are unintelligent for opposing spending when we are (allegedly) the beneficiaries; sounds like we are the responsible ones.
Unfortunately, this is not a Repub/Dem or red/blue battle; in its essence it is a battle between a New York/San Francisco/Chicago/Boston urban mentality that wants to "rule" the country with urban-centric policies vs. most of the rest of the country wants relative freedom and prudence and responsibility in government.
Create broad insults about intelligence, education, prejudice, if you will, but you will be very and sadly wrong.
January 5th, 2013
12:24 pm
Keep it up southern Republicans! Go ahead and destroy the Republican party. You are nothing but political carpetbaggers anyway.
You want to be Dixiecrats. Go for it. Have fun with no political power once it happens.


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