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Marcella's Italian Kitchen - Polaris
- Address:
1319 Polaris Parkway
Columbus, OH 43240Neighborhood:
- Cuisine:
ItalianPrice: $30 and under
Marcella's Italian Kitchen - Polaris
- Dining Style: Casual Dining
- Website: http://www.marcellasitaliankitchen.com/
- Phone: 6148446500x
- Hours of Operation:
Lunch: Monday - Friday 11:30 a.m. to 4:00 p.m. Saturday - Sunday 12:00 p.m. to 4:00 p.m.
Dinner: Monday - Thursday 4:00 p.m. to 10:00 p.m. Friday - Saturday 4:00 p.m. to 11:00 p.m. Sunday 4:00 p.m. to 9:00 p.m.
- Payment Options: AMEX,Diners Club,Discover,MasterCard,Visa
- Cuisine: Italian
- Executive Chef: Michael Ho
- Dress Code: Casual Dress
- Accepts Walk-Ins: Yes
- Additional Details: Banquet/Private Rooms, Bar Dining, Bar/Lounge, Beer, Cafe, Full Bar, Gluten-free Menu, Happy Hour, Late Night, Non-Smoking Restaurant, Patio/Outdoor Dining, Private Room, Takeout, Wheelchair Access, Wine, Wine Bar
- Private Party Facilities: Marcella's is available to host your private lunch or dinner event for 20 or more guests. Please contact the General Manager at to begin planning your special event today.
- Private Party Contact: Brett Nordstrom, General Manager 6148446500x
- Special Events: WINE ENTHUSIAST WEDNESDAYS
Receive half off all bottled wines on Wednesday nights.
Start a new Sunday family tradition at Marcella's
Dine with us Sundays and enjoy a Marcella's Chop Salad, Spaghetti & Meatball and a Choice of Chocolate, Pistachio or Honey Vanilla Gelato for only $15.95
Half Price Happy Hour at Marcella's Polaris
Join us for half price happy hour in our bar, cocktail lounge and patio Monday - Friday from 4:00 – 6:30 p.m. Enjoy half off our bar menu and $3 beers, $5 spirits & specialty cocktails, and ½ off select wines.
A word from Marcella's Italian Kitchen - Polaris
Marcella's Italian Kitchen is a bustling, urban burst of Italian flavor and energy. Serving lunch and dinner daily, Marcella's Italian Kitchen will have a lively atmosphere – whether it be for sharing lunch, dinner or a late night snack. The dynamic bar provides a vibrant venue for sampling from a selection of 50 Italian wines served by the bottle or quartino. The Italian menu features selections of olives, meats, cheese, hot and cold small plates, as well as a variety of pizzas, pastas and Italian specialties. Marcella's Italian Kitchen brings an authentic Italian cafe to the Polaris Town Center, located across the street from Polaris Fashion Place.Continued
Foodspotting photosSee all photos
Awards voted by OpenTable diners
- Diners' Choice WinnerItalian
Marcella's Italian Kitchen - Polaris - Best Restaurants in Polaris ›
Marcella's Italian Kitchen - Polaris reviews from OpenTable diners
138 reviews since May 26, 2014
- Food4.3Service4.1
- Ambiance4.1Noise LevelModerate
special occasion (52)good for groups (52)great for outdoor dining (35)fit for foodies (32)notable wine list (28)romantic (28)neighborhood gem (28)great for lunch (24)kid-friendly (16)vibrant bar scene (15)hot spot (15)great for brunch (9)late-night find (8)scenic view (6)Show More
- Disappointed with foodFoodFancyDined on 9/13/2014While it was nice to have our group of 8 in the private party room (lower noise level) and our server did a nice job staying connected with our table (though it seemed she was spread out among various large groups), the food was a disappointment. The one dish was barely warm and had to be sent back to be warmed up. My eggplant parmigiana was barely warm and lacked much flavor. The tomato sauce was bland. The wine selection was average at best. I'll think twice before going back.
- Good but loudbel14Dined on 9/13/2014The first thing we noticed when we walked in the door was how loud the restaurant was. It was a Saturday night so it was crowded, but it was a fun, energetic noise. The food was good and we enjoyed our dinner.Special Features:
- Gluten freeCarolDined on 9/7/2014Marcellas is my favorite restaurant!! Their gluten free options are excellent. The gluten free pizza is my favorite although the pasta is excellent as well. Also, the gluten free bread is awesome!Special Features:I would recommend this to a friend.
- Great food, wine, serviceOpenTable Diner Since 2014Dined on 9/5/2014My wife and I have been to Marcella's at Polaris a number of times, and we also have been to the short north location a lot, usually for happy hour. The food is always very good, and we like trying the different Italian wines they have. The attitude of the servers is also good, helpful but not overly serious. It is a popular restaurant though, so it is usually loud.Special Features:I would recommend this to a friend.
- sharpdocDined on 9/4/2014The giant meatballs are quite good, the pasta is meh. The gnocchi is ok, but the sauce is very undistinguished. The service was good, but this is probably going to be my last time at Marcella's.Special Features:
- not as good as normalOpenTable Diner Since 2014Dined on 8/30/2014I visit Cameron restaurants frequently due to gluten free availability. As always, our food was awesome. We were disappointed in a few things though. One we had to physically move the table as it was so close to the table next to us your backs were touching (neither party was heavy either). Our server was overly fake with kindness and we all found him to be quite obnoxious. Yes you should be kind, but it's obvious when you're trying so hard it's fake. It also took my brother several requests and 15 minutes to get normal stemware for his wine and this was after a snarky comment from our server that the glassware you use "is real stemware". If a guest asks for it, just get it.Special Features:I would recommend this to a friend.
- OpenTable Diner Since 2014Dined on 8/30/2014The food was excellent . Almost my Mom's meatballs and she made the best! Thank youSpecial Features:
- First visit, very impressedOpenTable Diner Since 2014Dined on 8/29/2014The extensive gluten free menu was amazing. They had gluten free bread that was delicious. Service was good. Wine list could have been a bit better. Patio was very nice. Traffic noise was surprisingly low.Special Features:I would recommend this to a friend.
- ComplaintGreatDined on 8/24/2014First time there for my family, there was 2 birthdays. Me an Husband really raved about Marcells's. The service was slow, food wasn't that good. I talked to the manager Bennett, an told her. She was nice, but still had to ask for more refills. Some of food was cold, server never told us about Sunday special, we had to ask. They was not crowded at all. My husband had been there before an had great service an food. Our bill was 279.37, plus 55.00 tip..I guess never brag about ant rest.on Sundays. Which we won't. There was 11 of us.I would recommend this to a friend.
- OpenTable Diner Since 2014Dined on 8/24/2014always well satisfied with the food, service and dollar value.Special Features:
- Mom's Night OutladyduskDined on 8/22/2014My Suster-in-law and I met for a moms night out. We ate and laughed and talked for a long time. Our server was incredibly gracious and helpful. She was knowledgeable about the wine list and helped us make a great selection. We shared small plates at the table and she made that very easy to order more at intervals and divided our check for us. We had a wonderful time. We had the zucchini (my favorite), arancini, olives, melted pecorino, and a pizza. Yum.Marcella's is one of my favorites and I will definitely be back!Special Features:I would recommend this to a friend.
- Wonderful Place to DineLouiseDined on 8/17/2014We celebrated our 30th wedding anniversary at Marsella's, and had a terrific experience. Our waiter was attentive, efficient and friendly. He even offered, and took our 30th anniversary photo for us. We will definitely go back again.Special Features:I would recommend this to a friend.
- Wonderful experienceFoodieWannaBeDined on 8/16/2014Everything was great! Have already recommended to friends.Special Features:I would recommend this to a friend.
- Don't bother with table reservationOpenTable Diner Since 2014Dined on 8/15/2014Make a reservation, show up on time, get handed a vibrating caller, wait 10 minutes. Don't bother with reservations.Special Features:
- Business LunchNightsOutDined on 8/15/2014Went with five business associates. Great lunch. Panini's were great and reasonable price for business lunch. Table was ready when we arrived. The server was efficient, and accurate. Very pleasant. Noise level was low which made it easy for conversation.Special Features:I would recommend this to a friend.
- MrWonderfulVIPDined on 8/13/2014We enjoyed the wide variety of menu options and tasty foodSpecial Features:
- Excellent!!!NotsogrumpygourmetDined on 8/12/2014Wonderful authentic Italian food! The veal meatball appetizer is to die for. Very impressed with all of our meals. My only knock would be the risotto, but still a very well put together dish with the chicken and broccolini.Special Features:I would recommend this to a friend.
- BarGreatDined on 8/9/2014The bar very noisy. Great top shelf Margritas, didn't ask but wish margeritas was on happy hour. Bartentenders very friendly.Special Features:I would recommend this to a friend.
- OpenTable Diner Since 2014Dined on 8/9/2014Unfortunately, with the exception of M and Molly Woo's, the service at the Cameron Mitchel restaurants has been unfortunate. Marcella's was better than either Cap City locaitions, but she was still very slow while the restaurant was not very busy.Special Features:
- Happy Hour with GirlfriendsDatenightDined on 8/5/2014This is our favorite Happy Hour spot. Like always, the food was delicious and it was a perfect setting. Unfortunately, our waiter was not as attentive as we are used to and was very awkward at times to interact with (ex. ordering drinks, delivering our food, ect) - it will not prevent us from coming back, however it was different than normal.Special Features:
- Excellent DiningDTJRDined on 8/2/2014All starts with a great staff. The Veal Meatball is a must. We are always pleased with Marcella's.Special Features:I would recommend this to a friend.
- Birthday DinnerBuckeyeMike1Dined on 8/2/2014Went to Marcella's for a birthday dinner. The food here is always good. The Melon and Prosciutto appetizer was wonderful. The Veal Meatball melts in your mouth. My dinner was very good. Ravioli Mezzaluna was GREAT. The goat cheese filling was not heavy and the portion was good. The bread was fresh and served promptly with our drink order. The waitress was not very attentive. She stood around for a several minutes in the back while we were trying to pay our bill and get to a movie. She did apologize and we were on our way. Would definitely go back!Special Features:I would recommend this to a friend.
- Food taste and quality just so sopeeweeDined on 8/1/2014First time visit and heard a lot about this place but to be honest it was just average and for the price you have a lot of much better Italian options out there than this.Special Features:
- Wonderful time!OpenTable Diner Since 2013Dined on 7/29/2014The food was wonderful and the service was outstanding. Thank you for a perfect date night!I would recommend this to a friend.
- Service was lackingMking113Dined on 7/28/2014Marcella's is one of our favorite restaurants, so when my daughter wanted to make a reservation for herself and a group of friends for her 16th birthday, I wasn't surprised. Unfortunately, she said their waitress was not attentive and they had to wait a long time for service and for their food. They had to flag down another waitress. I cannot imagine the restaurant being super busy as it was a Monday evening with 8pm reservation.Special Features:I would recommend this to a friend.
- Good food, not awesome for kidstravelinggazerDined on 7/26/2014Found Marcella's in a busy restaurant and retail area via the Open Table app., but it was not above average or excellent for the price. Our service was prompt, but I'm not sure that the server (albeit very kind) was very informed about dishes and recommendations. The lasagna and kids spaghetti were not spectacular, angel hair pomodoro was good...no "fried cheese (mozzarella sticks)" for kids :( Waiter suggested that fried risotto balls were a good substitute...(while adults liked them, the kids did not). Gelato was a nice surprise to the dessert menu!!Special Features:
- A Go-to Favoritelroach65Dined on 7/25/2014Amazing veal meatballs, as well as, other delicious Italian fare.Special Features:I would recommend this to a friend.
- Good for a large groupPhilBDined on 7/23/2014I have been here several times in recent weeks; this tome was with a group of eight from work. We were seated promptly and received excellent service. While this is not normally a quiet restaurant, we were seated in a separate room which was quite nice. Definitely recommend asking for this room if you have a group of eight or more. As usual the food was very good and I enjoyed a few bottles go the J Lohr Seven Oaks Cabernet. Overall a very good experience with a group.Special Features:
- FilipinaDivaDined on 7/19/2014Although some dishes were not as what the menu stated, overall,the food was very good. I have been there before and I would definately go there again. There were 8 in our party and all 8 enjoyed their meal.Special Features:
- Good Food, Poor ServiceAutoJunkie98Dined on 7/12/2014The good: food came quickly once ordered and was good but not great. Our waitress was pleasant. The bad: They could not find our reservation; gave us a pager telling me the table was almost ready but never paged us until I went back in to check, now 30 minutes after our reservation. All other customers had been seated. Then they thought our rsvp was for 2. They seated us but did not tell the waitress - we waited another 12 minutes before ever seeing anyone. She said the host never informed her. They did not provide us with appetizer plates, I stole them from an empty table next door. I never saw a manager doing rounds making sure everything was ok. I hope the downtown location is better, we will never come back to this location again.
- Great for particular eaters & kidsOpenTable Diner Since 2013Dined on 7/11/2014I went with my 5 year old and he absolutely loved the food. I am gluten free and they had SO many options and accommodated all my requests. My parents are vegetarians and they enjoyed their meal also.Special Features:I would recommend this to a friend.
- Get the meatballAlanArturoDined on 7/7/2014My wife and I love going to Marcellas. It's better than olive garden without being quite as pricey as some Italian restaurants. We've gotten several items, our favorite is the Chicken Parmesan. The Meatball appetizer is pretty great too.Special Features:I would recommend this to a friend.
- Great Food, Great Service. Love itBarbDined on 6/29/2014Sunday afternoon great time to stop in. Service was wonderful, 4:30 is a great time for a quite dinner.Special Features:I would recommend this to a friend.
- Anniversarycantw8Dined on 6/28/2014This is the perfect place to spend an anniversary. We couldn't have gotten a better evening any place else in Columbus. The service, food and ambience was outstanding and although we will be there many more times through the year, we can't wait until our 38th wedding anniversary. Simply excellent!!Special Features:I would recommend this to a friend.
- Never Disappoints!DonatellaDined on 6/28/2014I've been to Marcella's a number of times and it never disappoints! Food is always fabulous and the service is excellent as well. Highly recommend this as a place for an informal Italian dinner!Special Features:I would recommend this to a friend.
- Great serviceOpenTable Diner Since 2007Dined on 6/28/2014Food was nothing special one way or the other but our waitress went out of her way to be helpful --- with two small grandchildren in tow!Special Features:
- an intimate placedinernumeroUnoDined on 6/25/2014It was my first time at Marella's but will definitely not be my last. The food was great and the ambiance and decor just as good. I have been in search of a place built with love where great Italian food is served with genuine dedication to one's craft. I feel like I have found that place and I am sure my wife and I will make it a destination for some of our special occasions.Special Features:
- Loud mouth chiefOpenTable Diner Since 2014Dined on 6/21/2014The food was outstanding! The service was excellent! What wasn't good was the loud mouth lead chef who screamed at the preperation chefs the whole entire time!! We were seated 2 tables from the kitchen and he never stopped . Our waitress even apologized for all the screaming we had to listen to our entire meal. Other than that it was wonderful to reserve on line and be seated right awaySpecial Features:I would recommend this to a friend.
- Our favortie restarauntDrewDined on 6/20/2014You could probably throw a dart at this menu and leave beyond satified, but there are a few dishes I have to get everytime I come. If you do not get the veil meatball and the marg. pizza, you are truly doign yourself a disservice. The Penne al a vodka is amazing as well.Special Features:
- foodieVIPDined on 6/17/2014Celebrating Father's day... food was great. However, we waited almost 20 minutes for someone to approach our table after being seated and that only happened b/c we had to flag someone down. I hope this was just a fluke in service because have dined at both locations before and never had this problem.


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When Children Go Hungry
Experts say numbers of reported children suffering from hunger in Afghanistan are rising. As a mother, I can't help but wonder what I can do to make things a little better.
The front page of a recent New York Times is chilling. A shrouded woman holds a baby with a face so gaunt from hunger that his skin hangs in folds. He looks like an elderly man as he cries out in her arms. Malnutrition among the very young is on the rise in Afghanistan, and with so many possible reasons why, experts are confounded to declare one specific cause.
It's a story so grim, so full of defeat that I could hardly get through the whole thing. As a mom with three little kids and one more on the way, I can barely read this stuff anymore. It's simply too painful. I know what it takes to make my kids cry, and it's not much. When I think about how much effort I put into their well being every day—preparing fresh food, making sure their growing bodies get enough rest, teaching them the fundamental truths I believe in—and how exhausted I am by assuming their care, I can't understand how it works in the opposite direction. If it takes so much to raise a child in a happy and healthy environment, how can these children in Afghanistan survive such horrific experiences and go on?
That's when another part of me wakes up, the part who wants to help. Can I help? The only way to be useful is to better understand what's going on, so I read on.
The article points out that there's no one reason why more and more starving children are showing up in hospitals all over the war-torn country, offering instead only theories. There are mines in family gardens where food might otherwise have been grown, experts say. There's a culture where women are kept to their homes and only communicate with immediate family members, marginalizing efforts by global relief organizations to educate mothers on nutrition. Millions are displaced by war, it's reported, and even though UNICEF and Doctors Without Borders (among other agencies) have therapeutic feeding programs to offer, they can't reach many families in need.
And there's more. "The main cause of malnutrition in Afghanistan is lack of breast feeding," explains Dr. Khan in Helmand Province. "They see beautiful pictures of milk cartons and they think it's better." But most families don't have access to fresh milk, only powdered versions that must be mixed with water, clean water, which is often not available. Diarrhea is the result, and when there aren't many feeding options to turn to, things go downhill for these young children very quickly.
Millions and millions of dollars have been poured into this region, all aimed at "helping" and this is the best we can hope for? It reminds me of a book on poverty that I once read, The Hole in Our Gospel, which lays out the deep complexities of the very poor. They don't need more stuff, explains author Richard Steams, CEO of World Vision which is a Christian organization that pairs needy children with financial sponsors all over the world. Instead, he says they need jobs, infrastructure, clean drinking water, less corruption and more local leadership, among other things. How can I give that to them? I'm an educated person with a job of my own and a basic understanding of how the world works, not to mention a fiery temperament—surely those things can be put to use somehow.
But I still don't know.
My husband and I sponsor a few children through World Vision, and while it's only four kids in four very bleak corners of the world, this is one of the only ways I can get through a news story like this. We know there are kids who need someone to reach out, and for these four kids, we can say we'll help. We'll help with water, with education, with raising them up so they can be productive adults, and maybe even leaders, in their communities someday. We'll probably never meet any of them in person, but we're hoping that we can make an impact in their lives this way.
At least that's what I tell myself.
I'm not alone either. Millions of us are trying, along with massive efforts by professional relief organizations all over the world. It's still not quite working, but I say we've got to keep trying.

subset: commoncrawl


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The Crossroads of the Aether
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That is an insanely low cost to power such a high-performance device.
Well prior to 2007 most phones couldn't even do that without issues so it's all subjective to what the person considers high performance. Some think a mustang is high performance some think a Bugatti is high performance. Either way its still pretty cheap to charge this phone, lol.
these statistics are interesting but irrelevant compared to the cost of the device. very efficient relatively
So I guess my Home Cinema is using about $80 a year then. :/
iPhones, iPads, iDevices are gadgets.
Sure they are getting more powerful, but it is not even near what a desktop can do.
I don't get it. Charging from 0-100% while the device is turned off? How do you do that with an iPhone?
iPhones > gs3
It saves you 12 cents a year!:P I don't even know if that's right. Haha I am an apple fanboy but if you aren't buying cases etc. online but instead at stores a gs3 will save you a lot more money..
Also this years smartphones are high performance devices. They do more than 1/2 of what a laptop can do In the palm of your hand.. Look at laptops that were considere high performance years ago! 1gb+ used to be a great amount! And now that's on most smartphones.
It think you guys both are missing the point, and obviously don't use your smartphones very much. What exactly do you do on you computer that can't be done on a cellphone these days? Emails, cat videos, and po*n? My cellphone is used to take photos, make videos, edit video/photos, emails, make calls, watch movies, watch TV, transfer documents, scan documents, banking, set up business meetings, maintain and collect large amounts of data, steam music, etc....Now how much energy would it take to charge/power a video camera, photo camera, usb hardrive, mp3 player, desktop computer, LCD screen, streaming device (i.e., Roku, Apple TV), scanner, receiver, etc...?!
If you're talking about rending HDQ videos, playing Skyrim on Ultra, or creating 3D animation, you're right....but now you're just looking desperate for something/someone to troll.
i just say that i spend more bills then that 41 sense ..... come on


text: I would like to know how a 11-year-old can survive for more than a month in the streets? Where is Jerry Walker (Oakland, California), just checked, he is STILL missing. And no, there are no updated articles available, Jerry's only hope is right here, Tumblr, Facebook, Twitter, email - any social networks - let's use this tool to find him!


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Jewelry Appraisals
Appraising is an art, a science, a profession. The proper appraisal is your assurance that your interests will be protected and there will be prompt and accurate compensation in case of a loss. Intercontinental Gemology Laboratory, a division of Black, Starr and Frost, is one of only a few laboratories in the world specializing in the determination of country of origin of gemstones and of various enhancing treatments.
Jewelry appraisals have become ever so important with the rising prices in gold, platinum and diamonds. It is important to insure that your jewelry is adequately covered by your insurance company in the event of a loss. Often time's appraisals become out of date every 5-10 years depending on the quality and rarity of the item.
Trust our on-site profesional Certified Gemologists from the American Gemological Society to give you the most accurate evaluation of your jewelry.
Appointments Available on:


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This summer, Catonsville resident Kat Novak teamed up with Beagle Freedom Project to help a beagle rescued from an animal testing lab adjust to the life many dogs enjoy of running in the grass, and being petted and fed in a loving home.
Vito, who turned 4 on Sept. 3, was rescued from a laboratory in Washington, D.C., on July 15 along with six other dogs.
Novak, an animal trainer, cared for and rehabilitated Vito until Aug. 31 when he arrived at his new home in Pittsburgh, Pa.
"His permanent home was his birthday present," Novak said.
Beagle Freedom Project is a Los Angeles-based nonprofit established in 2004 to help find permanent homes for animals, usually beagles, used in testing. The organization works with the labs to take in those dogs that are no longer usable for testing and would otherwise be euthanized.
"Beagles are the breed of choice for laboratory research for the exact same qualities that make them great family pets," said Kevin Chase, director of operations for Beagle Freedom Project. "They use beagles because they know they're not going to bite you.
"At the end of the day — at the end of the research — we owe these dogs more than just a cold lonely death in a cremation oven," Chase said. "We owe them a soft spot on the couch."
Since the organization's first rescue two years and nine months ago at a Los Angeles laboratory, Beagle Freedom Project has rescued 126 beagles, three mixed-breed dogs, eight rabbits and two cats from 17 different laboratories in 21 different rescue missions, according to Chase.
Novak has a long history working with dogs, and applied to be a foster parent with Beagle Freedom Project because she said she strongly believes in the group's mission.
"I started my own dog training business [in 2006] that was Top Dog Canine Counseling," Novak said. "And then I started Catonsville dog walkers two years ago.
"I kind of connect with anything dog," she said.
Due to the uncertainty about when or where Beagle Freedom Project is able to conduct a rescue, Novak said she only had a few days notice before she picked Vito up from the Washington laboratory.
"I said, whenever you get a rescue on the East Coast, I would be happy to foster," Novak said. "They let me know, I think, four days before.
"Everybody was kind of anxious," Novak said of the day of the rescue. "I didn't really know what was going to happen."
The group met at a home not far from the lab where the beagles were released from their crates to experience the outside world for the first time.
"You couldn't not cry when you saw those dogs coming in," Novak said. "Their little faces were like, 'What's going on?'
"It was kind of surreal in a way, because you think what these dogs have been going through [is so bad]," she said. "Vito was standing there looking at me, so I said, 'OK buddy.' "
For the next month and a half, she cared for Vito like she would one of her own children, she said, socializing him with her other dogs, Mickey and Mary Ann, and introducing him to basic life experiences.
Having been bred and raised in a laboratory, Vito had never been exposed to anything as basic as the sound of a television or eating from bowl.
"Vito had never known anything," she said. "He wasn't used to daylight; he wasn't used to sunshine.


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Dorsey sees where he needs to go. In a report from the Wall Street Journal he says
"We have a lot of mainstream awareness, but mainstream relevancy is still a challenge," he said during a discussion at Columbia University's Journalism School Tuesday. Mr. Dorsey, who came up with the idea for Twitter, said Monday that he is returning to be product chief of the company; on Tuesday he outlined more about his plans for the next few months.
Mr. Dorsey said Twitter could make it easier for people to navigate the technology and do a better job of catering to people who use Twitter to get information rather than relay their own thoughts.
Amen to that. While relaying ones' own thoughts can be interesting at times it is a lot less interesting most of the time. And with Twitter's limited capabilities to archive and search much of what has been tweeted it can be a frustrating experience to get what you need from the service.
Dorsey has already created a stir amongst the TweetDeck and other Twitter client creators by telling folks to get beyond that kind of service. Is it because Twitter is going to do something on its own? Maybe. What Dorsey had to say about what could really be of interest was, well, interesting.
What does he want to see from Twitter developers? Mr. Dorsey says he has "no idea," but that more tools that combine information from Twitter with other services would be a good place to start.
"The interesting products out on the Internet aren't building significantly new technologies. They're combining technologies," he said.
That's not the first person I have heard that theory from (Bing!) and it seems to be right on target.
So what could Dorsey do to improve upon Twitter and make it accessible to the rest of the world? And, if more people get comfortable with the service will it continue to be the inane rantings of the masses or could it be even more of the kind of life enhancing tool that so many feel it already is?
What's your take?


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Shelly Palmer talks to Jeff Rosenblum, filmmaker and co-founder of the ad agency Questus. Rosenblum's new documentary, The Naked Brand, focuses on the death of an advertising model that's been around for 100 years and Rosenblum says we should be glad. He says corporations will change the world for the better in this new age of transparency. Listen to find out how!
Podcast: Play in new window | Embed


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KREM 2 Sports Director Darnay Tripp has highlights from a wild GSL shootout at Albi Stadium.
Shadle Park had the win within grasp thanks to 577 yards passing from Brett Rypien - a performance that put him past Connor Halliday for the GSL's single season passing mark. But Central Valley's Austin Rehkow booted a 67 yard field goal to force overtime for the Bears. They went on to win it on a Grayson Sykes touchdown run, 62-55.
Video of Rehkow's booming field goal can be found on YouTube.


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Streets around Wright Square to be closed for the "Rally For Justice Trayvon Martin."
Several church congregations expected to walk to City Hall and have a prayer service in Wright Square around 11 a.m. They will walk East on West Gwinnett to Montgomery Street, north on Montgomery to Charlton Street and then north on Bull Street to Bay Street.
A short prayer service on the south side of Bay Street before the assembly walks back to Wright square from 11 a.m. till about noon. Bay Street will not be closed but streets around City Market could be affected during the short prayer service in front of City Hall.
Expect traffic to be blocked at Whitaker and York streets, Bull and Oglethorpe Avenue, Drayton and President streets, Drayton and State streets, and Bull and Broughton streets for the duration of the rally. Drivers may experience intermittent delays as the procession makes its way to Wright square.
The rally is sponsored by Connor's Temple Baptist Church and First Tabernacle Baptist Church.
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For The Newly Diagnosed
Painting by - Tiffany Sage
For anyone who has been diagnosed with a serious disease what follows is often fear of the unknown. As the weeks turn into months the realization sinks in that you have a heath crisis on your hands. Quickly you find yourself seeking out information, looking for the right answers and asking yourself a few familiar questions; What can I do to improve my condition? Can this disease be treated, if so, when should I start treatment, or should I wait ?
For the millions of people who have been diagnosed with hepatitis C, the same questions need to be answered.
The Disease
In 2012 Medscape reported:
Out of 100 people that contract the infection, 75–85 people will develop chronic infection, 60–70 people will develop chronic liver disease, five to 20 people will develop cirrhosis over the course of their chronic infection and one to five people will
die of complications including hepatocellular carcinoma (HCC).
2014 - People With HCV Die Decades Earlier Then Persons Without The Disease
2012 - Hepatitis C increases risk of death from both liver disease and non-liver-related causes
Further down this page additional information on the newly oral FDA approved drugs to treat the hepatitis C virus will be provided.
Treatment is not for everyone, only you and your physician will determine what path you should investigate. However, if you are considering treatment, then arm yourself with accurate information.
The thought of treatment can be overwhelming, you may even see the side effects of treatment as much more detrimental then the disease itself. Or because the symptoms of hepatitis C manifest very slowly, it's easy to dismiss treatment because it appears that there is nothing to be treated. What ensues for some people living with hepatitis C is a lack of urgency to seek treatment.
Worth The Wait? Or Treat Now?
A collection of research articles weighing the risks and benefits of treating HCV now vs waiting for future therapies.
Provided below are helpful links to additional information on HCV including: support, FAQs, diet, transmission, books, videos, disease progression, treatment with current direct-acting antivirals and investigational antivirals, HCV tests, news
and research.
Need To Talk To Someone ?
Help is available, recently "Project Inform" announced the launch of a new national helpline, 877-HELP-4-HEP (877-435-7443), run by and for people affected by hepatitis C. The helpline operates Monday through Friday 9am to 7pm EST. To learn more, visit www.help4hep.org or email email@example.com.
American Liver Foundation HelpLine Service Adds a Dedicated Hepatitis C Specialist
Callers can now reach someone at the Helpline from 9:00 AM to 7:00 PM Eastern time, Monday – Friday.
In addition, questions sent on e-mail to firstname.lastname@example.com will be promptly answered.
Two Great Books
Hepatitis C Treatment One Step at a Time And Free From Hepatitis C
Lucinda K. Porter, RN, the author of "Free from Hepatitis C" has graced the HCV community with a second book "Hepatitis C Treatment One Step at a Time" available now on Amazon. A must read for anyone starting HCV therapy.
For the hands on reader check out the Multimedia section of the web site. This page contains udpated HCV educational podcasts, videos, and links.
Educate Yourself
Education-related information
Includes CME activities in various media formats covering the following topics: treatment regimens, resistance, current direct-acting antivirals, investigational antivirals, interferon alfa-free regimens, effects of HCV on the liver, diet,drug-drug interactions, and managing side-effects
What Is A Hepatologist ? What Is A Gastroenterologist?
Most hepatologists, although not all, are also gastroenterologists. These doctors have successfully completed both a hepatology and a gastroenterology fellowship.
Begin here with easy to read facts, from liver health and disease progression to new therapies, side effects, FDA inserts and more.
Welcome to HCSP Fact Sheet Webpage. The three different types of fact sheets are geared towards different audiences depending on their need or requirement for information. The Fact Sheets range from short, easy to understand, but relevant information to the more technical aspects of hepatitis C
Support Online
HCV Support
Med Help
WebMD® Hepatitis Community
Links To HCV Support On Facebook and Twitter
Cirrhosis - Transplant Support
Next up, what about the disease progression of hepatitis C ?
Disease progression
2013 - Hepatitis C - A Look At Disease Progression
The natural history of hepatitis C remains controversial. Among HCV-infected individuals progression to advanced liver
disease generally requires decades and is influenced by several host factors...
Medscape Gastroenterology - December 2013
Excerpt: Outcomes of Chronic HCV Infection
Natural history: The German HCV-contaminated anti-D cohort provides an ideal population to investigate the natural course of HCV infection in a large and homogenous cohort of young women followed from the date of HCV inoculation. Previous follow-up studies at 20 years and 25 years after infection suggested slow rates of fibrosis progression in this unique cohort. A prospective community-based multicenter study[10] reevaluated liver disease progression in 718 patients from the original anti-D cohort at 35 years after infection.
Patients with self-limited HCV infection were compared with those who did not eliminate the virus. In the overall cohort, 9% of patients showed clinical signs of cirrhosis at 35 years after infection. The women with self-limited HCV infection or SVR after antiviral treatment were protected from progressive liver disease and showed the best long-term clinical outcomes. Liver disease progression largely depended on HCV infection status.
This study provides further evidence for a mild but significant disease progression at 35 years after infection in the German HCV-contaminated anti-D cohort.
Benefits of HCV eradication.
For patients with chronic HCV infection, achieving an undetectable viral load reduces the risk for death by 45% and the risk for liver-related adverse events by 27%. McCombs and colleagues[11,12] documented the impact of viral load suppression and treatment on morbidity and mortality in patients with HCV infection receiving care through the US Veterans Health Administration.
Read more....
Transmission Of Hepatitis C
How is hepatitis C spread? Who's at risk?
Hepatitis C virus (HCV) is transmitted through contact with an infected person's blood. The following list outlines sources of hepatitis C transmission
-Sharing needles and syringes (IV drug abuse);
-Other possible risk behaviors: tattoos, body piercing, living and medical care in a developing country, folk medicine, intranasal cocaine;
Related - 2012 - Amateur tattoos carry hepatitis C risk
Related - IV User-Worried About HCV ? Check This Out
-Extensive surgical procedures
-Unknown--up to 5% of patients have no identifiable risk factors;
-Sexual transmission is rare; the risk of sexual transmission to an individual is probably less than 3% when a person is in a stable monogamous relationship;
-Vertical transmission from mother to baby
-Reused needles in a medical or health care setting.
According to the CDC:
In a recent analysis of data from a national health survey, 55% of persons ever infected with HCV reported an exposure risk of either (IV drug use or blood transfusion before July 1992), and the remaining 45% reported no known exposure risk
(CDC, unpublished data, 2012).
Other potential exposures include ever having received chronic hemodialysis, being born to an HCV-infected mother,
intranasal drug use, acquiring a tattoo in an unregulated establishment, being incarcerated, being stuck by a needle (e.g., in health care, emergency medical, home, or public safety settings) and receiving invasive health-care procedures (i.e., those involving a percutaneous exposure, such as surgery before implementation of universal precautions).
Is hepatitis C transmitted sexually?
According to studies in the Journal of the American Medical Association, a low sexual transmission rate of hepatitis C was suggested. Of the 62 patients studied, none of the monogamous heterosexual partners had developed the hepatitis C antibody. In general, the probable risk of heterosexual transmission of hepatitis C is less than 3%.
It is recommend that all patients in a non-monogamous relationship use a condom or spermicide and patients in a monogamous relationship use a barrier method only if they are anxious or concerned about transmission.
All non-monogamous individuals should use safe sex practices.
For patients with hepatitis C, testing of spouses, babies and significant others is recommended by Centers for Disease Control(CDC). Please discuss these issues with your physician.
Hey Can I Get Hepatitis C From.......
Dec 2013 AUDIO - Drs. Stephen A. Harrison and Norah A. Terrault discuss the article:
Sexual transmission of hepatitis C virus among monogamous heterosexual couples: The HCV partners study.
2012 - Hepatitis C Sexual Transmission Is Rare among Monogamous Heterosexual Couples
Sexual transmission of HCV among monogamous heterosexual couples: The HCV partners study
Related - 2011 - Hepatitis C Transmitted by Unprotected Sex Between HIV-Infected Men
The Sexual Transmission of Hepatits C In The HIV Population
Is hepatitis C transmitted by breast milk to infants?
There is no substantial evidence that hepatitis C is transmitted through breast milk, however, a few studies have been performed that tested breast milk and very rarely is hepatitis C found in the breast milk--even using the most sensitive tests such as PCR. The CDC has issued a statement explaining that mothers who have HCV can breast feed, but should avoid it if there are sores around the nipple.
Human breast milk inactivates hepatitis C virus infectivity
In an editorial published with the paper online September 24 in The Journal of Infectious Diseases, Dr. Ravi Jhaveri from the University of North Carolina in Chapel Hill says "the results provide a plausible explanation for why breastfeeding is not a risk factor for HCV transmission. This is reassuring for us as practitioners when we counsel our HCV patients that it is safe for them to breastfeed."
Can hepatitis C be transmitted to other members of my family (household contacts)?
There is a slight risk of hepatitis C transmission among household contacts, so family members should not share items such as razors or toothbrushes that may transmit blood or secretions. Women who have hepatitis C and are menstruating as well as men or women with hepatitis C and sores in the genital area should avoid sexual contact. The CDC recommends that spouses or partners of a hepatitis C patient be tested for hepatitis C.
Can a pregnant woman give hepatitis C to her baby?
A report in New England Journal of Medicine suggested a 7% transmission rate of hepatitis C from mother to child at birth. Though this is a high estimate, the possibility of transmission must be considered when a woman with hepatitis C is deciding whether to have children.
For infants who have received the hepatitis C virus from their mother, brief elevations of liver enzymes may occur, but no chronic liver disease has been reported. There have been no reports of cirrhosis in newborns, infants or child due to mother-to-child hepatitis C infection. It is recommended that all babies born to mothers with HCV be tested annually until age three with antibody tests.
October 2013
Hepatitis C - Pregnant women may pass heartier viral strain to newborns
Infants who get hepatitis C from their mothers during childbirth may inherit a viral strain that replicates more quickly than strains found in non-pregnant hosts, according to a new study published Oct. 27 in Nature Medicine. The findings, from a team in The Research Institute at Nationwide Children's Hospital, are the first to describe how a virus that has infected 180 million people worldwide takes advantage of immune changes during pregnancy
Women with AIDS and hepatitis C are at high risk for transmitting the virus to their babies, and research has shown that these women consistently transmit the virus to their babies at birth.
Is hepatitis C transmitted by insects?
There is no documented transmission of hepatitis C through insects. The virus, however, is related to a group of viruses including yellow fever and Dengue, and those are known to have been spread by insects.
Exams and Tests
The following tests are done to help diagnose hepatitis C:
Learn more here
Related - Hey, I Have A Question About HCV Tests
The Tests
Diagnosis of HCV infection is based on the detection of anti-HCV antibodies by enzyme immunoassay.
Anti-HCV test detects the presence of antibodies to the virus, indicating exposure to HCV. This test cannot distinguish between someone with an active or a previous HCV infection. Usually, the test is reported as "positive" or "negative." There is some evidence that if the test is "weakly positive," it may be a false positive. The Centers for Disease Control and Prevention (CDC) suggests that weakly positive tests be confirmed with the HCV RIBA test before being reported.
HCV recombinant immunoblot assay (RIBA) test is an additional test ordered to confirm the presence of HCV antibodies. In most cases, it can tell if the positive anti-HCV test was due to exposure to HCV (positive RIBA) or represents a false signal (negative RIBA). In a few cases, the results cannot answer this question (indeterminate RIBA). Like the anti-HCV test, the RIBA test cannot distinguish between a current or past infection.
Can you have a "false positive" anti-HCV test result?
Yes. A false positive test means the test looks as if it is positive, but it is really negative. This happens more often in persons who have a low risk for the disease for which they are being tested. For example, false positive anti-HCV tests happen more often in persons such as blood donors who are at low risk for hepatitis C. Therefore, it is important to confirm a positive anti-HCV test with a supplemental test as most false positive anti-HCV tests are reported as negative on supplemental testing.
Can you have a "false negative" anti-HCV test result?
Yes. Persons with early infection may not as yet have developed antibody levels high enough that the test can measure. In addition, some persons may lack the (immune) response necessary for the test to work well. In these persons, research-based tests such as PCR may be considered. . How long after exposure to HCV does it take to test positive for anti-HCV? . Anti-HCV can be found in 7 out of 10 persons when symptoms begin and in about 9 out of 10 persons within 3 months after symptoms begin. However, it is important to note that many persons who have hepatitis C have no symptoms..
Hepatitis C RNA assays to determine virus levels (called viral load)
Viral Load Test
How long after exposure to HCV does it take to test positive with Qualitative HCV RNA test =PCR?
It is possible to find HCV within 1 to 2 weeks after being infected with the virus
Unlike antibody tests, HCV RNA tests directly measure for the presence of the hepatitis C virus. HCV RNA tests may be qualitative or quantitative.
Qualitative HCV RNA tests are used to diagnose hepatitis C. Your doctor might choose to perform an HCV RNA test instead of the ELISA, especially if you are at high-risk for hepatitis C. The HCV RNA test will be positive in as little as 1 to 2 weeks after exposure.
A positive HCV RNA test means a person has hepatitis C infection.
Quantitative HCV RNA tests allow your doctor to determine exactly how much virus is in the blood. This is referred to as the viral load.
Related - HCV Viral Load Test
The viral load is usually expressed as units per milliliter or copies per milliliter. In patients with chronic hepatitis C infection, viral loads vary widely from 50,000 to 5 million copies per milliliter. A higher viral load may not necessarily be a sign of more severe or more advanced disease but it does correlate with likelihood to respond to treatment. HCV RNA tests can also be used to monitor response to hepatitis C treatment. For example, if the viral load decreases during treatment, this suggests that treatment is working and should be continued, referred to as response guided treatment . Conversely, if the viral load remains the same, it suggests that the patient is not responding to treatment.
Related - Testing Positive For Hepatitis C
On-Treatment Predictors of Response
Once hepatitis C virus (HCV) treatment is started, initial viral kinetics are helpful in predicting treatment outcome. Patients who have cleared the virus by Week 4 of therapy, whether with protease inhibitor (PI)–based triple therapy or with peginterferon/ribavirin alone, are very likely to achieve sustained virologic response (SVR). By contrast, those who still have detectable HCV RNA (virus) levels by Week 12 of therapy have very low likelihood of obtaining SVR
Viral Load - Familiar Treatment Terms
Response guided treatment-
Or viral load monitoring during treatment is intended to enable the physician to determine the duration of combination therapy based on a patients viral response.
Terms Used In Response guided treatment
(RVR)-Rapid Viral Response; Is an undetectable viral load four weeks into treatment. In SOC-standard therapy if you have an RVR your chance of cure is better than 78% and 92% and your doctor may recommend that you shorten your treatment.
(cEVR) Complete early viral response- Is an undetectable viral load 12 weeks into treatment. If you have a complete EVR you have a good chance of being cured .
(pEVR) Partial early viral response - A drop in viral load of at least 2-log (e.g. from 600,000 IU/mL down to 6,000 IU/mL) at 12 weeks of treatment, but still detectable virus in your blood. In people with genotype 1 the chance of viral clearance is low and treatment is generally stopped.
(non-EVR) Non-response- No significant drop in viral load in the first 12 weeks of treatment.
Related - Standardization of Terminology of Virological Response in the Treatment of Chronic Hepatitis C
What Is A 100-fold reduction in viral load ?
Changes in viral load are sometimes expressed in terms of logs: a 1-log change means a 10-fold increase or decrease; a 2-log change is a 100-fold increase or decrease.
What Is A 2 Log Drop?
Example: 2 log drop = 15,000,000 IU/Ml to 150,000 IU/mL; a viral load that starts at 15,000,000 IU/mL and does not decrease to 150,000 IU/mL or lower.
Terms Used To Define Patients
Naïve- No prior treatment/first time treating HCV.
Relapsers- People whose viral load drops to an undetectable level with treatment but rises again after treatment ends.
Partial responders- People who have at least a 2 log10 (100-times) drop in viral load, but do not reach undetectable levels in the blood by week 24.
Null responders- People who failed to reduce their viral load by at least 2 log10 (100 times) after 12 weeks of prior treatment, which is the currently recommended Food and Drug Administration (FDA) definition for clinical trials of investigational hepatitis C treatments.
How Will I Know If Treatment Is Working?
The standardized term "SVR" was defined as being HCV RNA negative 6 months after finishing standard therapy. This surrogate endpoint used in clinical trials has been interpreted by researchers as a 'cure'.
Recently, both the Federal Drug Administration (FDA) and the European Medical Agency (EMA) have shortened the post-treatment follow-up period necessary to define an SVR by introducing the so called SVR12, defined as HCV RNA undetectability 12 weeks following PegIFN/Rbv.
Learn More About Treatment Response
Aug 19 2014
Treating HCV- Learning The Basics
In order to gain a better understand of treating HCV, a review of the basics, especially treatment response, is a necessary first step. By doing so, participating in the decision process and communicating with a healthcare provider is made easier, if treatment is needed.
SVR - sustained viral response
Is SVR12 As Good As SVR24?
Posted on June 17, 2013 by Kristine Novak, PhD, Science Editor
In patients with chronic Hepatitis C virus (HCV) infection, a sustained viral response to treatment regimens 12 weeks after therapy (SVR12) is a good indicator that the response will be maintained until week 24 (SVR 24), based on an analysis of pooled clinical trial data published in the June issue of Gastroenterology. Therefore SVR12 can be used instead of SVR24 as a primary end point for registration trials.
A SVR24 (undetectable levels of HCV RNA in serum 24 weeks after completion of therapy) is considered to indicate successful treatment—most patients who achieve SVR24 maintain their serum-negative status and have reduced complications from liver disease and increased survival times. It is therefore the primary endpoint of HCV therapy trials for regulatory approval—efficacies of all HCV therapies approved by the US Food and Drug Administration have been based on the proportion of patients attaining SVR24. However, earlier time points could increase efficiency of drug development.
Jianmeng Chen et al. assessed data from 15 phase 2 and 3 trials, 3 pediatric studies, and 5 drug-development programs to determine the concordance between SVR24 and SVR12, and even SVR4. They analyzed data from groups of subjects who received various combinations and regimens with interferon, ribavirin, and direct-acting antiviral agents.
Of the 13,599 adult subjects in the database analyzed, 50.6% achieved SVR24 and 51.8% achieved SVR12. These appeared to be mostly the same patients—the positive predictive value of SVR12 for SVR24 was 98% and the negative predictive value was 99% among subjects with genotype 1 HCV infection. A similar level of concordance was observed in subjects with HCV genotype 2 or 3 infections, as well as in pediatric studies.
The positive predictive value of SVR4 for SVR24 was 91% and the negative predictive value was 98% in subjects with genotype 1 HCV infection. Chen et al. observed similar values regardless of subjects' race, sex, treatment experience, genotype 1a vs 1b, or presence of cirrhosis.
Why is there such a high level of agreement between SVR12 and SVR24, and to a lesser extent SVR4 and SVR24? Chen et al. explained that 65% of subjects who relapsed had detectable viral load by week 4 after treatment and 95% had detectable viral load by week 12. So if the virus is going to reappear, in generally does so within 12 weeks after the treatment ends.
The authors conclude that individual patients should be followed for 24 weeks or longer after treatment to confirm their responses. But SVR12, which is currently used as supportive information for registration trial design, can also be appropriate for regulatory approval of treatment regimens.
- Viral genotyping is used to determine the kind, or genotype, of the HCV virus present. There are 6 major types of HCV; the most common (genotype 1) is less likely to respond to treatment than genotypes 2 or 3. Genotyping is often ordered before treatment is started to give an idea of the likelihood of success and how long treatment may be needed Treatment
Treatment According To Genotypes.
A better understanding of Genotypes and treatment
The following tests are done to identify and monitor liver damage from hepatitis C:
Liver function tests
Albumin level
Prothrombin time
Related - A better understanding of Liver Function Tests
Will I need a Liver Biopsy ?
Based on the abundant literature in chronic hepatitis C, alternative, non-invasive methods can now be used instead of liver biopsy in patients with chronic hepatitis C to assess liver disease severity prior to therapy at a safe level of predictability.
All About Fibroscan
Understanding Fibroscan results - Score Card
News and Updates
Liver Biopsy and Noninvasive Tests For Fibrosis
Newly Approved Ultrasound Device Eliminates Risks and Pain of Liver Biopsy
FDA Approves FibroScan for Noninvasive Liver Diagnosis
A painless alternative to liver biopsy for evaluating the stage of liver fibrosis.
When you are first exposed to the hepatitis C virus and become infected, you are said to have "acute hepatitis C". Most people have no symptoms of infection during this time.
In 70 to 80 percent of people, the infection becomes chronic. The word "chronic" implies that the infection will be prolonged, or even lifelong, unless you get treatment that cures the infection.
Many people with chronic hepatitis C have no symptoms, even if there is serious liver damage. Of those who do develop symptoms, the most common symptom is fatigue; other less common symptoms include nausea, lack of appetite, muscle or joint aches, weakness, and weight loss.
Related - Symptoms .
Treating Hepatitis C
Feb 2014
Recently, the AASLD/IDSA launched an up-to-date guidance for the treatment of hepatitis C. The new guidelines will have a complex algorithm for practitioners around the country to follow and see whats the right treatment, for the right patients, for the right about of time. Information includes both newly FDA approved drugs sofosbuvir and simeprevir, as well as off-label use for specific HCV combinations.
Click here to begin reading...................
What if I can't tolerate interferon ?
2014 - Alternative Treatments For HCV
Review article: management of chronic hepatitis C in patients with contraindications to anti-viral therapy
No Interferon - No Shots
HCV drug combinations to keep an eye on, not yet FDA approved
A Once-Daily Fixed-Dose Combination Pill of Sofosbuvir and Ledipasvir (Gilead) is currently in clinical trials.
Gilead's FDA approved drug Sovaldi (sofosbuvir) is a nucleotide analog polymerase inhibitor that works by blocking an enzyme the hepatitis C virus needs to copy itself, the drug has potent antiviral activity against HCV genotypes 1-6 and Ledipasvir, an NS5A inhibitor (not yet FDA approved, has potency against genotypes 1a and 1b.
Gilead tested its combo pill at a variety of treatment durations both with and without ribavirin. In three clinical trials deemed ION-1, ION-2 and ION3, initial results after 8 weeks of treatment demonstrated cure rates over 90 percent for some patients. View the December press release here, - Jan 12 2014 -Gilead Files for U.S. Approval:Ledipasvir/Sofosbuvir Fixed-Dose Combo For Genotype 1 Hepatitis C
Daclatasvir ( Bristol-Myers) and Sofosbuvir (Gilead)
In the January 16 issue of the "New England Journal of Medicine" (View Full Text @ NATAP) researchers reported that patients with genotypes 1, 2, or 3 who were given daclatasvir plus sofosbuvir, with or without ribavirin, for 12 or 24 weeks achieved cure rates from 89% to 100%. According to Paul Pockros, MD, of the Scripps Clinic in La Jolla, Calif., who was not part of the study - if daclatasvir is approved on its own, it's likely some doctors at least will prescribe it with sofosbuvir off label. Bristol-Myers recently announced daclatasvir will get an accelerated review by European regulators, in addition the EMA allows for compassionate use of the daclatasvir-sofosbuvir.
Read more here....
What New Drugs Have Been FDA Approved In 2013?
December 6 2013
Sofosbuvir FDA Approved
Gilead's Sovaldi (Sofosbuvir) Is Now FDA Approved
Sovaldi is approved in HCV genotypes 1 and 4, treatment-naïve adults in combination with PEG-IFN and ribavirin and the first approved interferon-free treatment regimen for people with HCV genotypes 2 and 3. Overall cure rates are at 80%, response rates and treatment duration varies, depending on genotype, viral and host factors.
November 22 2013
OLYSIO™ (simeprevir) Receives FDA Approval for Combination Treatment of Chronic Hepatitis C
Johnson & Johnson's protease inhibitor Simeprevir is approved for the treatment genotype 1, in combination with peginterferon alfa and ribavirin in adults with compensated liver disease, including cirrhosis, who are treatment-naïve or who have failed previous interferon therapy (pegylated or non‑pegylated) with ribavirin.
Download FDA Review Package For Sofosbuvir or Simeprevir.
FDA Approved Treatments For Hepatitis C
2014 FDA approved hepatitis C treatments
Sovaldi/sofosbuvir Homepage
Prescribing information, financial assistance, research articles and important updates
OLYSIO/simeprevir homepage
Prescribing and patient information, research and news
News and Updates
Incivek and Vicrelis
Clinical Trials
To learn more about Hepatitis C virus clinical trials or to find out if a study is enrolling patients in your area, please click here.
Clinical Trial Updates
ClinicalTrials.gov: updated in the last 30 days
HCV Drugs In Development
Hepatitis C Pipeline
Quick Links - Hepatitis C Investigational Drugs
News, Research And Clinical Trials
See **Clinical Trials @ HCV Advocate For Enrollment Information
AbbVie is a new, independent biopharmaceutical company composed of Abbott's former proprietary
pharmaceutical business
News and Research
ABT-450/r - ABT-267 - ABT-333-non- nucleoside
r = ritonavir
**Clinical Trials @ HCV Advocate-AbbVie
News and Research
Sovaprevir (ACH-3102)
**Clinical Trials @ HCV Advocate-Achillion
Boehringer Ingelheim
News and Research
Faldaprevir w-PPI-668/deleobuvir(BI207127)
Faldaprevir/ (BI 201335)
**Clinical Trials @ HCV Advocate-Boehringer Ingelheim
Bristol-Myers Squibb
News and Research
GS-7977 now Sofosbuvir/BMS-790052 now Daclatasvir,
**Clinical Trials @ HCV Advocate-Bristol-Myers Squibb (BMS)
News and Research
(Sofosbuvir) now Sovaldi
GS-7977 sofosbuvir /GS-5885 ledipasvir,
Sofosbuvir (GS-7977)
Ledipasvir (GS-5885)
GS-0938 and Sofosbuvir
**Clinical Trials @ HCV Advocate-Gilead
News and Research
Simeprevir/Samatasvir (IDX719)
**Clinical Trials @ HCV Advocate-Idenix
News and Research
Simeprevir now Olysio
Simeprevir (TMC435)
**Clinical Trials @ HCV Advocate-Tibotec / Janssen
News and Research
Victrelis (Boceprevir)
**Clinical Trials @ HCV Advocate-Merck
News and Research
**ClinicalTrials.gov - Danoprevir
Santaris Pharma
News and Research
**ClinicalTrials.gov - Miravirsen
News and Research
Incivek (Telaprevir)
As a reminder (VX-135) is still on partial clinical hold by the FDA in the U.S.
**Clinical Trials @ HCV Advocate-Vertex
Links To More Information
These links will take you to the premier Hepatitis C sites and keep you informed with breaking news, clinical studies, new drugs, podcasts, newsletters, support, personal experiences and more.
2014 FDA approved hepatitis C treatments
Sovaldi/sofosbuvir Homepage
Prescribing information, financial assistance, research articles and important updates
OLYSIO/simeprevir homepage
Prescribing and patient information, research and news
News and Updates
Incivek and Vicrelis
Clinical Trials
To learn more about Hepatitis C virus clinical trials or to find out if a study is enrolling patients in your area, please click here.
Clinical Trial Updates
ClinicalTrials.gov: updated in the last 30 days
HCV Drugs In Development
Hepatitis C Pipeline
Quick Links - Hepatitis C Investigational Drugs
News, Research And Clinical Trials
See **Clinical Trials @ HCV Advocate For Enrollment Information
AbbVie is a new, independent biopharmaceutical company composed of Abbott's former proprietary
pharmaceutical business
News and Research
ABT-450/r - ABT-267 - ABT-333-non- nucleoside
r = ritonavir
**Clinical Trials @ HCV Advocate-AbbVie
News and Research
Sovaprevir (ACH-3102)
**Clinical Trials @ HCV Advocate-Achillion
Boehringer Ingelheim
News and Research
Faldaprevir w-PPI-668/deleobuvir(BI207127)
Faldaprevir/ (BI 201335)
**Clinical Trials @ HCV Advocate-Boehringer Ingelheim
Bristol-Myers Squibb
News and Research
GS-7977 now Sofosbuvir/BMS-790052 now Daclatasvir,
**Clinical Trials @ HCV Advocate-Bristol-Myers Squibb (BMS)
News and Research
(Sofosbuvir) now Sovaldi
GS-7977 sofosbuvir /GS-5885 ledipasvir,
Sofosbuvir (GS-7977)
Ledipasvir (GS-5885)
GS-0938 and Sofosbuvir
**Clinical Trials @ HCV Advocate-Gilead
News and Research
Simeprevir/Samatasvir (IDX719)
**Clinical Trials @ HCV Advocate-Idenix
News and Research
Simeprevir now Olysio
Simeprevir (TMC435)
**Clinical Trials @ HCV Advocate-Tibotec / Janssen
News and Research
Victrelis (Boceprevir)
**Clinical Trials @ HCV Advocate-Merck
News and Research
**ClinicalTrials.gov - Danoprevir
Santaris Pharma
News and Research
**ClinicalTrials.gov - Miravirsen
News and Research
Incivek (Telaprevir)
As a reminder (VX-135) is still on partial clinical hold by the FDA in the U.S.
**Clinical Trials @ HCV Advocate-Vertex
Links To More Information
These links will take you to the premier Hepatitis C sites and keep you informed with breaking news, clinical studies, new drugs, podcasts, newsletters, support, personal experiences and more.


text:
16 U.S. Code § 414 - Trespassing for hunting, or shooting
Every person who shall trespass upon any national military parks for the purpose of hunting or shooting, or who shall hunt any kind of game thereon with gun or dog, or shall set trap or net or other device whatsoever thereon for the purpose of hunting or catching game of any kind, shall be guilty of a misdemeanor, punishable by a fine of not more than $1,000 or by imprisonment for not less than five days or more than thirty days, or by both fine and imprisonment.
Source(Mar. 3, 1897, ch. 372, §§ 2, 5,29 Stat. 621, 622.)
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text:
Former assistant district attorney Mindy Montford joined FOX 7 live in the studio Friday to answer questions about the Gabrielle Nestande's sentence.
On Friday Nestande was sentenced to 10 years probation for criminally negligent homicide for hitting and killing Courtney Griffin with her car.
Montford helped explain the sentence and gave her opinions on the controversial verdict that elicited strong reactions from many people in Central Texas.
KTBC FOX 7119 East 10th StreetAustin, TX 78701Phone: (512) 476-7777Fax: (512) 495-7001


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Discover Adionomy, Your Online Radio Advertising Campaign, Fast, Easy and Custom-Made!
Mango Funk is an afro-venezuelan funk band that fusions genres such as: funk, afro-venezuelan rythms, dance & pop. Their first album goes by the name of "El Nuevo Beat del Tambor". In this first album they present a new sound consisting of afro rythms with a touch of funk, electronica and latin flavor.
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|Home | Software downloads | Submit | Drivers | Codecs | Linux | Scripts |
Podite has released alterPod v0.7.1b for the most
Podite has released alterPod v0.7.1b for the most daring of iPod users out there. alterPod is a tool that allows you to edit the strings and display graphics in your iPod's firmware as well as performing a firmware backup/restore. At the core of alterPod sits Austin Che's command-line tool ipodedit; alterPod provides an easy-to-use GUI interface for the command line tool.
alterPod now includes a String Editor, and an Image Browser.
dlTube.net did not scan alterPod 0.7.1b for viruses, adware, spyware or other badware.
For your own safety, we recommend that you always have an antivirus, with virus definitions up to date, installed on your computer when downloading and installing programs from the web.
Audio : Business : Desktop Management : Developer Tools : Drivers : Games : Graphics : Home & Education : Internet : Network Tools : Security : System Utilities : Video : Web Authoring


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A Way with Words and the 501(c)(3) nonprofit corporation which produces the show depends directly on listeners like you. It cannot exist without listener donations.
Donate By Mail: Wayword, Inc., P.O. Box 632721, San Diego, CA 92163
You've made A Way with Words a hugely popular independent public radio show!
The podcasts have been downloaded almost 9,000,000 times, and since July 2012, the show's over-the-air and online listenership has climbed more steeply — pushing the program into the top 10% of all public radio shows in North America. That's without financial or marketing support from NPR.
podcast downloads, 2009-2014
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In fact, our biggest source of program funding — more than half of it — comes directly from you, our listeners.The show can only happen if you help support it! Please give now.
With your help, we produce a great-sounding national show with just five part-time people, and with a budget that's tiny compared to other national programs. There's no large overhead. No big facilities to support. No huge payrolls. We do a lot with a little.
Donate now to support the program. Your donation is tax-deductible.
You can also donate by postal mail: Wayword, Inc., P.O. Box 632721, San Diego, CA 92163.
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They were among the roughly 220 laws added to the books this week after their adoption by lawmakers earlier this year.
A federal judge has put the sex-trafficking legislation's controversial centerpiece – targeting online want ads for sexual services – in limbo. But other pieces taking effect give hope to activists and bill sponsors that a dent can be made in the human-trafficking business.
Among them is a law letting authorities seize and obtain a forfeiture of property used by offenders to further their sex-trafficking crimes, including automobiles. Another lets people convicted of prostitution clear their names if they can prove they were forced into it by sex-traffickers.
"I think we have the best laws in the nation. … It will make a difference if our law enforcement enforces them," said Rose Gundersen of Thurston County, who leads Engage Washington and, along with other activists, helped support action this year. "It will take (community) organizing to get police to recognize it is a problem.''
Gundersen said her group is now working with others in a Thurston County alliance that will try to raise public awareness of the law and the need for enforcement. It plans a meeting June 21 in Lacey to start the work.
"Human trafficking is a billion-dollar industry that exploits the most vulnerable, especially minors," Democratic Sen. Jeanne Kohl-Welles of Seattle said. "I hope other states can follow Washington's lead.''
Kohl-Welles co-sponsored with Republican Sen. Jerome Delvin of Richland the centerpiece of the trafficking reform, which makes it illegal to advertise sex services involving a minor.
Backpage.com, which operates an online clearinghouse for escorts, is challenging that piece of the package, arguing that it is trumped by federal statute.
Federal Judge Ricardo Martinez issued a temporary restraining order earlier this week that keeps that law from taking effect, spokesman Dan Sytman of the state Attorney General's Office said. A preliminary injunction could be considered June 15, delaying the law even longer, Sytman said.


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PURELL® Advanced Skin Nourishing Instant Hand Sanitizer Foam provides advanced antimicrobial germ kill and this green certified formula meets EcoLogo® hand sanitizer standard EL UL 2783 for environmental leadership and proven performance. PURELL Advanced is made from 100% naturally renewable ethanol, meeting the USDA BioPreferred program biobased content standards. Readily biodegradable non-aerosol foam formula provides broad-spectrum antimicrobial efficacy. With six moisturizers for optimal skin conditioning, it's clinically proven to improve skin condition in 14 days. This PURELL Advanced formula is fragrance free, dye free and compatible with latex, nitrile and vinyl gloves, and CHG. Meets CDC and APIC recommendations.
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During a recent survey, when asked if PURELL® Products were made available in a quick-serve restaurant1:
1. Results based on nationwide online survey of 1,508 individuals, conducted in March, 2005 by GOJO Industries. The expected range of error at 95%. Confidence level for any one question is +/- 1.1% to +/- 2.5%.
We're eager to know how our customers feel about GOJO products. From now until September 5th, 2014, we'll reward every 25th visitor who reviews a product*.
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For an additional chance to win, review another product! Each review you write for a unique GOJO product counts as a new entry in the giveaway.


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December 24, 2013
Around the Web
Birthday: January 3
Hometown: La Jolla, CA
Where You've Seen Her: The beautiful Danica McKellar has come a long way since she played a prepubescent boy's dream girl, AKA Winnie Cooper on The Wonder Years. After strutting her grown-up stuff in a 2010 issue of Maxim, Danica landed a spot on our 2010 Hot 100 list, and later, a recurring role on the TV series Young Justice. Now, you can see her in the Lifetime TV movie The Wrong Woman, airing December 28. Adapted from the Hitchcock film The Wrong Man, this may be the first (and last) time we ever sit through a Lifetime movie.
Get to know another girl, Megan Boone, and don't forget to place your vote in Maxim's 2014 Hot 100!


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Robert Pattinson's publicist had him walk out of an interview with Ryan Seacrest after Seacrest asked him about his relationship with his Twilight co-star Kirsten Stewart. See the video of Ryan Seacrest's interview with Rob Pattinson below.
Ryan Seacrest asked what everyone wants to know… about Rob Pattinson's relationship with Kristen Stewart. But Rob's publicist wasn't having any of that and rushed him out of the studio.
The video below shows the publicist motioning Rob to leave after Seacrest asked the question (maybe ignoring the request not to ask about that subject for the interview). Seacrest just asked surprised and said, "We can't ask that question? You can't ask that question to the guy? It's his co-star! It's a fair question!"
Rob Pattinson threw his hands in the air and got up to leave while Ryan Seacrest said, "This is the first time ever!" Seacrest later posted this comment on Twitter "Robert Pattinson is [a] class act. However the rep he was with yanked him off the air and off the mic when I asked about Kristen. Unreal!"
Click thumbnails for larger pictures
Images: wenn.com
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Fanny Hill: Memoirs of a Woman of Pleasure was one of the most banned and censored books in the history of literature. John Cleland (a contrary man of letters, prone to boasting and getting into trouble with the law) wrote it while he was in Fleet debtor's prison. First published in 1748 and withdrawn within a year, it was not legally republished until a hundred years later. Widely considered to be the first example of literary erotica and a stylistic tour de force, with its combination of charm, daring and love of pleasure.
The story is told by means of a series of uninhibitedly explicit letters from Fanny to an unknown friend, looking back over her colourful life and the characters she meets, as an innocent girl of 15 arriving in London. Now widely available at a computer near you, read by one of Britain's finest.
Public Domain (P)2000 Aquarium Audio Books
"A reader lives a thousand lives before he dies. The man who never reads lives only one." - Jojen Reed. #ADanceWithDragons
"No wonder this book was banned in Britain..."
First of all... this book contains A LOT of very MATURE content that I would NOT suggest to ANYONE under the age of 18.
Now on to the actual review... I honestly must say I didn't know what exactly I was getting myself into when a friend of mine suggested I the book to me. It was a very graphic audiobook with very vivid descriptions to say the least. The actual content of the story itself was very blasé if you ask me. It was somewhat predictable in most places and you could definitely see where the book itself would end up. To use the term very loosely, this was a coming of age book, a young girl who (due to tragedy and a series of unfortunate situations) is forced to get herself involved into a very 'controversial' lifestyle and the way she maneuvers her way through it. As stated, the book to me is very predictable... that being said though the descriptions are impressive to say the least.
The narration was in effect underwhelming at best, could most definitely be much better than it was. The narrator sounds like an old woman rather than a young, naive girl. The character of course matured in the book but the narration did nothing, in my opinion, to enhance the overall quality of the experience.
All in all however, the book was pretty ok at best but not exception.
I love all genres of books. However, when I listen to audio books as I clean, garden, drive they are better with a lot of heat!
"Not really erotica"
Fanny Hill is probably the most well known native English erotica ever made.
Fanny is a girl forced into a life she didn't make, and does pretty well for herself.
The sex is not very explicit by todays standards
The only issue for me is that the writing is tough to slog through (very dated) and you do find yourself re-listening parts to figure out precisely what just happened.
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2 U.S. Code § 102 - Repealed.
Section, R.S. §§ 60, 61; Pub. L. 86–628, § 105(c),July 12, 1960, 74 Stat. 461, required submission by Secretary of Senate and Clerk of House to two Houses of statements as to persons employed and as to expenditures and balances on hand and providing for printing of such reports as Senate and House documents. See sections 104a and 104b of this title.
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
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