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Lobster Mac & Cheese
Holiday foods can be decadent but come just once a year, so they can fit into an overall plan. If you indulge in a treat like this one, balance it out with other meals and get in some activity - and enjoy every delicious bite. Get back on track the next day.
Active Time: 20 minutes
Total Time: 45 minutes
Amount: 8 servings
8 ounces Essential Everyday™ Penne Rigate Pasta
½ cup Essential Everyday Butter, divided
1 tablespoon chopped garlic
6 tablespoons Essential Everyday All-Purpose Flour
3 cups whole milk, warmed
1½ cups Essential Everyday Shredded Mild Cheddar Cheese
1½ cups Essential Everyday Shredded Mozzarella Cheese
1¼ cups Essential Everyday Fancy Shredded Parmesan Cheese, divided
¼ teaspoon cayenne pepper, optional
8 ounces cooked lobster meat, torn into chunks
4 slices Essential Everyday Thick Cut Bacon, cooked and crumbled
1 medium tomato, seeded and chopped
1½ cups Japanese-style Panko bread crumbs
Note: Can be baked in individual ramekins; reduce bake time by 5-10 minutes.
KTBC FOX 7119 East 10th StreetAustin, TX 78701Phone: (512) 476-7777Fax: (512) 495-7001


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Depression: Using Positive Thinking
What is an Actionset?
Depression is an illness that makes a person feel sad and hopeless much of the time. It's different than feeling a little sad or down. Depression can be treated with counseling or medicine, or both.
Positive thinking also can help prevent or control depression.
Key points
If you would like more information, see the topic:
Return to topic:
Positive thinking, or healthy thinking, is a way to help you stay well by changing how you think. It's based on research that shows that you can change how you think. And how you think affects how you feel.
Cognitive-behavioral therapy, also called CBT, is a type of therapy that is often used to help people think in a healthy way. CBT can help you learn to replace negative thoughts with positive ones. These negative thoughts are sometimes called irrational or automatic thoughts.
Working on your own or with a counselor, you can practice these three steps:
The goal is to have positive thoughts come naturally. It may take some time to change the way you think. So you will need to practice positive thinking every day.
Test Your Knowledge
Cognitive-behavioral therapy (CBT) is a type of therapy that can help change how you think about yourself.
You need to see a counselor to do CBT.
Changing the way you think can help you replace negative thoughts with helpful ones. This can help you cope with depression and may help keep it from coming back.1
Maybe you weren't able to close a sale or get a big project done at work. Or perhaps a relationship has ended. It's normal to feel down. But you've had trouble sleeping. You can't enjoy many of your usual activities. And you're blaming yourself. "I'm a failure at everything," you tell yourself.
The more you think about yourself in a negative way, the harder it is to feel hopeful and positive. The negative thinking makes you feel bad. And that can make you feel more depressed, which leads to more bad thoughts about yourself. It's a cycle that's hard to break.
But with practice, you can retrain your brain. After all, you weren't born telling yourself negative things. You learned how to do it. So there's no reason you can't teach your brain to unlearn it and replace negative thinking with more helpful thoughts.
Positive thinking also can help you manage stress. Too much stress can raise your blood pressure and make your heart work harder, which can increase your risk for a heart attack. Stress also can weaken your immune system, which can make you more open to infection and disease.
Although you can use CBT on your own, it's important to talk to your doctor or a counselor if you feel that your mood is getting worse. You may need more help.
Test Your Knowledge
Positive thinking can help you stop negative thoughts that make depression worse.
Positive thinking can help your health in other ways.
Stop your thoughts
The first step is to stop your negative thoughts or "self-talk." Self-talk is what you think and believe about yourself and your experiences. It's like a running commentary in your head. Your self-talk may be positive and helpful. Or it may be negative and not helpful.
Ask about your thoughts
The next step is to ask yourself whether your thoughts are helpful or unhelpful. Does the evidence support your negative thought? Some of your self-talk may be true. Or it may be partly true but exaggerated. There are several kinds of irrational thoughts. Here are a few types to look for:
Choose your thoughts
The next step is to choose a more positive, helpful thought to replace the unhelpful one.
Keeping a journal of your thoughts is one of the best ways to practice stopping, asking, and choosing your thoughts. It makes you aware of your self-talk. Write down any negative or unhelpful thoughts you had during the day. If you think you might not remember at the end of your day, keep a notepad with you so you can write down any irrational thoughts as they happen. Then write down a helpful message to correct the unhelpful thought.
If you do this every day, positive or helpful thoughts will soon come naturally to you.
But there may be some truth in some of your negative thoughts. You may have some things you want to work on. If you didn't perform as well as you would like on something, write that down. You can work on a plan to correct or improve that area.
If you want, you also could write down what kind of irrational thought you had. Journal entries might look something like this:
Test Your Knowledge
Which of these thoughts is an example of positive thinking?
I've had a couple of bad relationships. I know I'll never have a good relationship.
I feel bad that I didn't get as big a raise as I wanted. But there may have been reasons that had nothing to do with me. I'll talk to my supervisor to see if there is anything I can do to get a bigger raise next time.
How can a daily journal help you have more positive thoughts?
It makes you aware of your self-talk and can help you come up with helpful thoughts to correct an irrational thought.
Writing in the journal every day will help positive thinking come naturally to you.
Now that you have read this information, you are ready to practice positive thinking to help cope with depression.
eMedicineHealth Medical Reference from Healthwise
This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
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Main Content
Show everyone that the Roadrunners reign supreme with this Triple Conference adjustable hat from Top of the World featuring an embroidered school wordmark at the crown, embroidered team logo on the right panel and a woven team name on the adjustable strap.
- 65% Acrylic/35% Wool
- Adjustable hook and loop fastener strap
- Imported
- Officially licensed collegiate product
- Quality embroidery
- Six panels with eyelets
- Structured fit
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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B·A·R Honda drivers Jenson Button and Takuma Sato will line up on the 4th and 5th rows of the grid for tomorrow's Hungarian Grand Prix after posting the
8th and 10th fastest times of this afternoon's qualifying session.
It's all change in the
running order as some interesting
strategies clearly came into play
at the Hungaroring, where the
track temperature peaked at a
scorching 51°C. As such, it's difficult to know how tomorrow's 70-lap race will shape up but both Jenson and Takuma are happy with the balance of the B·A·R Honda 007s after a solid morning's progress and the team is eager to pick up where it left off last weekend in Germany.
Free Practice 3 Position: 11rd Fastest lap time: 1:23.902
Free Practice 4 Position: 7th Fastest
lap time: 1:21.301
Qualifying Position: 8th Lap time: 1:21.302
"8th on the grid is not a great
position to be starting from but
hopefully we have a good strategy
compared with the cars in front
of me. I feel that I was unable
to get much more out of the car
today because we had pretty low
grip. It also looks like we will
have some different competition
to fight with tomorrow.
I'm sure we can achieve our
target of some good points from
here though so we'll see
what tomorrow brings. Hopefully
the temperature will have cooled
by a few degrees as well."
Free Practice 3 Position: 14th
Fastest lap time: 1:24.070
Free Practice 4 Position: 9th Fastest lap time: 1:21.880
Qualifying Position: 10th Lap Time: 1:21.787
It was a better day for me today. In the morning
we worked on the set-up which we could not do yesterday
due to lost running
time. We caught up nicely and I was happy with the balance of the car. In qualifying
I felt that I had less grip and a bit of oversteer
in the middle sector cost me a
little time. In the end it was
a reasonable lap and we now look
to see what we can do from this
position and hope that we have
a strong package for tomorrow."
"We are reasonably happy with our qualifying slots and both drivers had good clean laps. We suspect there are different strategies at play in the front half of the field,
therefore it is hard to draw any definite conclusions.
The cars are fairly wellbalanced and we hope our homework will pay good dividends tomorrow."
"The drivers did a good job in very hot weather conditions.
This morning we continued the good set-up work from yesterday and achieved a lot of solid preparation for the qualifying session. This
afternoon, Takuma lost a bit of time in the second sector but both drivers performed well against
our expectations for today. We'll have to see how the various strategies unfold tomorrow but I am looking forward to a strong race for us."
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DOE Nanoscale Science Research Centers
Other Links of Interest
Muruganathan Ramanathan and Seth Darling of the Electronic & Magnetic Materials & Devices Group have won the Best Photon Micrograph award at the 54th International Conference on Electron, Ion, and Photon Beam Technology & Nanofabrication, held in Anchorage, Alaska, in June 2010.
The image is a bright field optical micrograph of a poly(styrene-block-ferrocenyldimethylsilane) (PS-b-PFS) block copolymer thin film. The polymer was spin coated on a thin TEM membrane and subjected to hybrid thermal/solvent annealing. This artistic structure appears because of the selective dewetting of the polymer from the thin TEM window (seen in the middle), which oscillates during the process of spin coating.
The micrographs selected this year will be on display at next year's conference.
A total of 88 entries were submitted to the contest, which covered work in a wide range of fields including micromechanical, photonic, and integrated circuit fabrication, chemical and dry etching, carbon nanotube structures, carbon nanotube growth experiments, biological samples, material science experiments and, e-beam, ion beam, and photolithography experiments.
The panel of judges who selected the award winners was:
June 2010
The Center for Nanoscale Materials is an Office of Science User Facility operated for
the U.S.Department of Energy Office of Science by Argonne National Laboratory


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The House">White House on Tuesday quickly panned the new budget proposal from Rep. Paul Ryan, R-Wis., saying it would slow the nation's economic recovery and hurt the middle class.
"To build real, lasting economic security for the middle class, the President and Democrats in Congress have a plan to grow our economy from the middle out, not the top down, and create more opportunities for every hardworking American to get ahead," said the White House in a statement. "Unfortunately, Republicans in Congress do not have a plan that works for the middle class and the House Republican Budget is the same old top-down approach.
"Because of a stubborn unwillingness to cut the deficit in a balanced way by closing tax loopholes for the wealthy and well connected, the House Republican Budget would slow the economy, stack the deck against the middle class, and threaten the guaranteed benefits seniors have paid for and earned," the statement continued.
Ryan, the House Budget Committee chairman, unveiled his latest fiscal blueprint on Tuesday. The plan would cut spending by $5.1 trillion over the next decade, achieving balance by 2014. Ryan's proposal does not raise taxes, would repeal Obama's health care reform law, institute changes to Medicare benefits, and bring about sharp cuts to domestic programs.
The budget stands no chance of becoming law, but the White House was quick to reject the proposal. Democrats made Ryan's budget proposals a centerpiece of their attacks during the 2012 campaign -- when Ryan was the GOP vice presidential nominee -- and are likely to do so again ahead of November's midterms.
President Obama has said helping the middle class will be a focus of his second-term economic agenda. The White House said Ryan's budget would "raise taxes on middle class families with children by an average of at least $2,000 in order to cut taxes for households with incomes over $1 million."
The White House also warned of deep cuts to infrastructure, medical research and education and said the the Republican plan would "end Medicare as we know it, turning it into a voucher program and risking a death spiral in traditional Medicare."
Obama unveiled his own budget proposal in March, a $3.9 trillion plan that provided new spending for domestic programs, the administration claims would boost job growth.
"The House Republican Budget stands in stark contrast to the President's Budget, which would accelerate economic growth and expand opportunity for all hardworking Americans, while continuing to cut the deficit in a balanced way," said the White House on Tuesday.
"Budgets are about choices and values," the statement added. "House Republicans have chosen to protect tax breaks for the wealthiest rather than create opportunities for middle class families to get ahead."


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Itzhak Perlman has made klezmer recordings in the past. Here he has joined forces with the renowned cantor Yitzchak Meir Helfgot and his klezmer collaborator and arranger Hankus Netsky for a set of mostly sacred Jewish music, much of it lamenting and dramatic, interspersed with a couple of instrumental pieces. Perlman plays with the sweet-toned, vocal eloquence that has always been a feature of his musical style, with pliant lines, rhythmic freedom and a sense that the music is flowing directly from his imagination (one wonders how much of what he plays is fully scored).
Helfgot sings with an extraordinary intensity and power, a beseeching tenor crying out and filled with emotion, and always somehow with a higher note or two in reserve. The best-known sacred song, Kol nidrei, comes last, in a moving but essentially simple performance. Before it is Sheyibone Bays Hamikdosh, a ten-minute mini-drama with virtuosic singing and the violinist in increasingly free and ecstatic partnership.
Many of the tracks have the feel of dramatic narratives, often in several segments. Some have the slow–fast bipartite structure familiar from gypsy music, to which some are very close in style. Perlman has a couple of numbers to himself, one of them a terrific medium-paced dance with klezmer band and a clarinet as sideman. It's gripping stuff, vividly recorded.
From the October 2012 issue. Subscribe to The Strad or download our digital edition as part of a 30-day free trial.
London Concertante
Hellen Callus (viola) Phillip Bush (piano)


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By BILL BARROWAssociated Press
HARTWELL, Ga. (AP) - The governors and lawmakers from South Carolina and Georgia have promised cooperation on water management issues in the Savannah River Basin.
Georgia Gov. Nathan Deal and his South Carolina counterpart, Nikki Haley, headlined a meeting of elected officials, conservationists and Army Corps of Engineers representatives on Wednesday.
The group met with fanfare at Lake Hartwell, a man-made reservoir near the top of the Savannah River that divides the two states.
Officials signed an agreement to update drought management plans for the basin. That's the latest phase of a long-term study of Savannah River management financed by the federal government and both states.
The governors said they hope the cooperative spirit prevents new litigation over water usage.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Find a Auburn, Australia bed and breakfast for your romantic weekend getaway. Intimate b & bs are cozy, romantic accommodations that are perfect for a mini-vacation, honeymoon, or wedding anniversary celebration. You will love the unique charm of our Auburn, Australia inns. Many guesthouses include complimentary breakfasts and unbeatable hospitality. Browse our bed & breakfasts and plan your Auburn, Australia romantic getaway today!
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Auburn, Australia Bed & Breakfasts - Amy's house is a stunning early Australian design fully self-contained bed and breakfast set in a tranquil garden featuring the latest country decor, it offers a beautiful blend of old world charm and modern day comfort.
Auburn, Australia Bed & Breakfasts - Cygnets at Auburn, built in the 1800s from local stone, is today a beautifully restored property in the historic village of Auburn, gateway to the Clare Valley. Cygnets offers 4 star accommodation in the heritage cottage and stable suites.
Lyndoch, Australia Bed & Breakfasts - 2 fully self contained 2 bedroom cottages set amid an australian bush garden in South Australias' Barossa Valley, Australias premier wine district.
coober pedy, Australia Bed & Breakfasts - Underground bed and breakfast is a five bedroom four bathroom two kitchens two lounges two outdoor barby living areas ,safe and secure undercover car parking
Blacktown, Australia Bed & Breakfasts - Blacktown City central location, selection of 2 & 3 bedroom serviced & furnished apartments accommodation for short and extended stay
Sydney, Australia Bed & Breakfasts - Sydney South Central location, luxurious studio & 1 bedroom hotel apartments accommodation suitable for daily or extended stay. All our self contained hotel apartments include full kitchen,internal laundry and security car parking.
Sydney, Australia Bed & Breakfasts - One of Sydneys top B&Bs, Clean. Comfortable and close to the Heart of the city centre Ashfield Manor offersd you all the comforts of home.A short trip to Olympic Park.Transport by bus or rail at your door. Nightly and weekly rates available
Denmark, Australia Bed & Breakfasts - Aspects is a stunning modern pole house built among the karri trees with amazing water views, just three kilometres south of Denmark. The home comfortably sleeps six guests, and has three bedrooms (two queens and one set of bunks).
Emerald, Australia Bed & Breakfasts - Set amongst the majestic gum trees of Emerald in Victoria's Dandenong Ranges only 55km south-east of Melbourne Victoria. Wake in the morning to the bird chorus whilst you enjoy a coffee and your Breakfast from the Gourmet Hamper included.
Via Morisset/Lake Macquarie, Australia Bed & Breakfasts - Escape to secluded indulgence. In the Watagan Forest floodlit & romantic. King beds, spa, lounge kitchenette, crackling fire, abundant wildlife. Sumptuous breakfasts. Candlelit dinners by. Come, enjoy this scenic lake, forest & vineyard region.


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Take a tour with Jennifer Little and find out more about artworks in the gallery. This tour is ideal for hearing impaired and deaf visitors. It will be delivered in British Sign Language.
The next tour in British Sign Language will be on Sunday 18 January, 3 - 4pm.
Jennifer Little studied BA (Hons) History of Art and Design with Practice at Manchester Metropolitan University. She is an experienced tour leader and regularly delivers tours in British Sign Language at Tate Modern, National Gallery and the Wallace Collection. Her next event at Tate Britain will be a talk on Francis Bacon on 12 Dec.
She has translated an architectural tour of the Bridgewater Hall into BSL. Jennifer's own art practice is as a 'walking artist' with her walks being closely related to deaf culture and childhood memories.


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All Towneplace Suites by Marriott in the USA and Canada have a smoke-free policy that applies to guest rooms, restaurants, lounges, meeting rooms, public space and associate work areas . To accommodate the needs of smoking guests, Hotels will have designated smoking areas outside of the property .
|Check-in Policy
|Check-out Policy
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Family Fun at Aunt Grace's Stay 'N Play
Lakeview, Arkansas Hotels & Resorts
Clean and spacious stone cottages. Large pool and picnic grounds. Minutes to Bull Shoals lake and the White river. Real kitchens or you can eat out or Bar-B-Q. Pizza can be delievered pool side or to your room. Pets are welcome. Free WI-FI....
Starting at $75 Per Night
Suburban Extended Stay
Bentonville, Arkansas Hotels & Resorts
The Suburban Extended Stay Bentonville is conveniently located off I-540, within one mile of the corporate offices of Wal-Mart and Sam's Club, minutes ...
$50 Per Night
Microtel Inn Bentonville
Bentonville, Arkansas Hotels & Resorts
Microtel Inn & Suites by Wyndham Bentonville seven miles from Fayetteville, AR (XNA-Northwest Arkansas Regional) Airport, and local attractions include ...
$50 Per Night
La Quinta Inn And Suites Bentonville
Bentonville, Arkansas Hotels & Resorts
La Quinta Inn and Suites Bentonville?is a mile from Scottsdale Center, 10 miles from Beaver Lake, and approximately 29 miles north of Drake Field Airport ...
$72 Per Night
Springhill Suites By Marriott Bentonville
Bentonville, Arkansas Hotels & Resorts
Conveniently located near Walmart and Tyson Foods corporate headquarters, Springhill Suites by Marriott is designed for guests who need spacious and functional ...
$65 Per Night
Sleep Inn Bentonville
Bentonville, Arkansas Hotels & Resorts
The Sleep Inn Bentonville is located approximately 30 miles from Fayetteville Municipal Airport and 120 miles from Tulsa International Airport. ...
$49 Per Night
Comfort Suites
Bentonville, Arkansas Hotels & Resorts
Our beautifully decorated spacious all-suites hotel is between two large shopping, eating, and entertainment complexes, all within walking distances and ...
$74 Per Night
Doubletree Bentonville Rogers
Bentonville, Arkansas Hotels & Resorts
The DoubleTree Suites by Hilton Bentonville hotel is located near the headquarters of Wal-Mart Stores, Inc., Sam's Club, Tyson Foods, and J.B. Hunt Transportation. ...
$62 Per Night
Travelodge Bentonville
Bentonville, Arkansas Hotels & Resorts
The Travelodge Bentonville is located two miles from the Sam Walton Museum, 10 miles from the Pea Ridge Museum, and 25 miles from the University of Arkansas. ...
$36 Per Night
Holiday Inn Exsts Bentonville
Bentonville, Arkansas Hotels & Resorts
The Holiday Inn Express & Suites Bentonville is located just 3 miles from downtown. Stay Smart at the Holiday Inn Express. ...
$68 Per Night
Active Cave Exploration
Ozarks, Arkansas Cave Exploration
Tame Cavern tour ( about 45 minutes ); and two extreme cavern tours, not for the faint of heart ( from 3-5 hours ). We provide helmets, headlights, knee-pads, and gloves; and hot showers. Rock and mineral shop. Spectacular bluff, and waterfall....
Starting at $12 Per Person
Renew & Relax at Fire Om Earth Retreat Center
Eureka Springs, Arkansas Spiritual
Spiritually Creative Workshops & Retreats Nightly & Weekly private cabin rental Yoga - Tai Chi - Bellydance -...
Creek's End Riverside Retreat
Parthenon, Arkansas Vacation Rentals
Comfortable, well-stocked vacation rental located right on the banks of the Little Buffalo River. Beautiful wooded mountain location with hiking trails and plenty of relaxation!...
Affordable Rates from $125 Per Night
1st Choice Cabins
Jasper, Arkansas Vacation Rentals
A Great Vacation awaits you at 1st Choice Cabins! Enjoy your stay in the Ozark Mountains and the Buffalo National River Country....
Rates from $140 Per Night
Lake Forest Cabins in the Beaver Lake Area
Eureka Springs, Arkansas Vacation Rentals
Luxury Log Cabins in the Beaver Lake Area of Beautiful Eureka Springs, Arkansas. All cabins sleep 1 - 10 persons. Seasonal Swimming Pool, Fireplaces, BBQ grills, 2 person jacuzzi tubs....
$149 Per Night
Rustic Luxury at the Buffalo River Lodge
Ozarks, Arkansas Bed & Breakfasts
The Buffalo River Lodge offers rustic luxury with a romantic atmosphere in the Ozark MTNs. near the Buffalo National River. Guests can escape to the serentiy of 62 scenic acres. Relax by the waterfall and koi pond while enjoying landscaped gardens. ...
$79 Per Night
A Eureka Springs Favorite for Over 28 Years
Eureka Springs, Arkansas Bed & Breakfasts
Quiet Historic District residential street with plenty of free parking - One block walk or trolley to shops, spas & cafes. A full breakfast is served on our balcony overlooking "America in Bloom" award winning gardens. Some rooms with TWO BEDS...
Starting at $95 Per Night
A Wedding at Hidden Acres
Eureka Springs, Arkansas Bed & Breakfasts
Hidden Acres offers small, intimate weddings at our chapel or gazebo with professional photographs in digital black and white or color format. You may reserve one of our B & B cottages with its own personal hot tub for a honeymoon package or getaway....
Catherine's Landing, an RVC Outdoor Destination
Hot Springs, Arkansas Campgrounds & RV Parks
Encompassing one mile of water frontage on Lake Catherine in Hot Springs, Arkansas; this is your ideal natural environment mixed with your favorite hotel experience....
$36 Per Night
Mar Mar Resort, Tackle Shop & Big Phil's Guide's
Ozarks, Arkansas Hotels & Resorts
We have regular sleeping rooms and kitchenettes with two beds in each. Microwave, coffee pot, refrigarator, tv and free wifi. Fishing tackle shop on premises. We are 500 feet from Marina. We have fishing guide trips for the Wht. River & Lake....
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We're Seeing Starz
Hulu Plus gets an upgrade, studios and publishers seeking "Rights of Publicity", a fan-assembled Star Wars documentary, and Leo's new diet.
Download or subscribe to this show at twit.tv/fr.
We invite you to read, add to, and amend our show notes at wiki.twit.tv.
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Gosh I love a good bite of propaganda. But maybe instead of "good" I should demur to "appealing"; it's probably a bit redundant to say that I don't brook with the smug-mongering on FOX, and even if it's couched in concern for the personal safety of Americans, the advisories that our government puts out on the countries of our brothers and sisters in South American scared the dickens out of my mom when I decided to do Carnaval in Colombia.
Point being, we're surrounded by propaganda. And I know Oliver Stone thinks so too. The fact appears to be the motivation behind his new movie South of the Border (opens Fri/16 in Bay area theaters), in which he travels down there to meet with Hugo Chavez and seven other leaders of what he believes to be the new Bolivarian movement. "I think that there has been so much unbalance [in American coverage of Latin America] that we are definitely a counter to that," the director told the New York Times. Read more »
Today, Johnny and Tim talk about the Mehserle verdict, the riots, and what comes next. You can listen after the break. Read more »
It's easy for political analysts to talk about "the Latino vote" as if 15 million people in California all shared exactly the same views and cared about exactly the same issues. Which is nuts: Latino voters are a diverse group.Read more »
I guess that's nothing new, and I could have written the same headline dozens of times over the past couple of years. But in this case, the Bay Citizen has a nice scoop -- Newsom personally scuttled a deal that would have created a $50 million annual stream of affordable housing money because he didn't want to be on record supporting any new taxes.Read more »
Today's Look: Melissa, Union Square
Read more »
BJÖRK AND DIRTY PROJECTORSMount Wittenberg Orca
Mount Wittenberg Orca is neither the first nor last time Björk sings about oceans, mothers, and plant life (re: "Oceania"). But now, she has the genius of the Dirty Projectors – in particular, producer and Dirty frontman David Longstreth – looking at Mother Nature, too. Read more »
By Joseph E. Stiglitz
NEW YORK – It was not long ago that we could say, "We are all Keynesians now." The financial sector and its free-market ideology had brought the world to the brink of ruin. Markets clearly were not self-correcting. Deregulation had proven to be a dismal failure.
The "innovations" unleashed by modern finance did not lead to higher long-term efficiency, faster growth, or more prosperity for all. Instead, they were designed to circumvent accounting standards and to evade and avoid taxes that are required to finance the public investments in infrastructure and technology – like the Internet – that underlie real growth, not the phantom growth promoted by the financial sector.
The financial sector pontificated not only about how to create a dynamic economy, but also about what to do in the event of a recession (which, according to their ideology, could be caused only by a failure of government, not of markets). Whenever an economy enters recession, revenues fall, and expenditures – say, for unemployment benefits – increase. So deficits grow. Read more »
Mayor Gavin Newsom and his business community allies often accuse progressive members of the Board of Supervisors of being too "ideological" in their proposals, particularly when they involve revenue or regulations. But a looming battle over reforming the city's business tax – one of three new revenues set for a special Budget & Finance Committee meeting tomorrow (7/9) at 11:30 am – shows that an ideological aversion to taxes of any kind drive Newsom and the business community more than their stated concern for "jobs" and the "economy." Read more »
The jury has reached an involuntary manslaughter verdict in the murder trial of Johannes Merserle, the former BART cop who shot and killed Oscar Grant, and Oakland City Hall has been evacuated in anticipation of the response. The judge has announced that the jury rejected the two more severe verdicts -- 2nd degree murder and voluntary manslaughter -- which could prompt an angry response from some protesters.Read more »
Who do you drink to? I guess it really depends on what you're drinking. Moonshine: The Devil Makes Three. Thug Passion: Tupac. Shot of a Patron, beer back: Very Be Careful. And hell no I'm not getting mom on you -- that's the vallenato five-piece from Los Angeles that's ready to party with you next week at The Rickshaw Stop (Thurs/15). VBC, formed by brothers Ricardo (accordian) and Arturo (bass) Guzman, sticks pretty close to the sounds that originated in their hard-partying parents' homeland in the sun-soaked Colombian Caribbean coast. Read more »
WAVVESKing of the Beach(Fat Possum)
With King of the Beach, Nathan Williams, Billy Hayes, and Stephen Pope have finally stopped adding "v"s to their name. After Wavves (2008) and Wavvves (2009) of unpolished lo-fi, these San Diego-based upstarts have elevated to a dreamier, more whimsical sound (re: "When Will You Come"). Yet Wavves also hearkens back to Blink-182, Sum 41, and the bygone days of summer in the '90s. The new album's delightful pastiche is thanks, in part, to Dennis Herring, who's produced the likes of Counting Crows, Elvis Costello, Modest Mouse, and the Hives. Goodbye dissonant noise; hello pop punk! Read more »
More bloodthirsty coverage of the San Francisco IndieFest's horror-fest offshoot, Another Hole in the Head, in this week's Guardian.
Another Hole in the Head's two documentary offerings concern themselves with the distinctly American roots of two related strains of genre filmmaking. Elijah Drenner's American Grindhouse traces the history of exploitation film, with a particular focus on the grindhouse theater as a cultural institution. Narrator Robert Forster recounts the tendency of even the earliest films to cater to prurient interests, and how the establishment and eventual dissolution of the Motion Picture Production Code stimulated the development of exploitation subgenres. The featured film clips are impeccably selected, mixing titillation and shock with a healthy sense of humor about the over-the-top absurdity of films like Ilsa: She Wolf of the SS (1975). Surprisingly candid interviews with gore luminary Herschell Gordon Lewis and blaxploitation director Larry Cohen prevent the film from taking on a too-self-important tone — these folks knew they were making b-pictures, and were damn proud of it. One of the most charming aspects of the documentary is the juxtaposition of different attitudes, wherein one interviewee will sing the praises of a classic, followed in quick succession by another talking head declaring it to be trash. It feels like John Landis gets the most screen time of any subject, but his charisma as well as the breadth of his oeuvre make it seem appropriate.
More bloodthirsty coverage of the San Francisco IndieFest's horror-fest offshoot, Another Hole in the Head, in this week's Guardian.
Grotesque (Koji Shiraishi, Japan, 2009) When did gorno stop being sick and start becoming sad? In Koji Shiraishi's Gurotesuku, or Grotesque – banned in the UK – a chainsaw is brought to chests, arms, legs, and fingers when really it should be brought down on this celluloid garbage. Shiraishi presents a film that is sloppy, badly written, badly acted, and is above all things, deeply unentertaining. The plot is as thin and drawn-out as one of the protagonist's intestines: While on a date, two dumbfucks get picked up by a craaaaaazy doctor (at least I think he's a doctor – and I think he's lost his board certification) who proceeds to do sick but unoriginal things to them (sawing off a girl's fingers and stringing them on a necklace for her BF? C'MON!). There are some brief moments of respite, albeit painfully acted and ridiculous respite, but the torture tries not to let up its chokehold on the audience. Unfortunately, it just ends up being a chokehold on our time. Fri/16, 5 p.m. and Sun/18, 7 p.m., Roxie.
Read more »
I know this is political heresy, but I was encouraged by the results of the Field poll on Boxer and Fiorina. I remember back in 1982, when Milton Marks, then a liberal Republican state senator, challenged incumbent Congressmember Phil Burton -- the legendary Democratic leader -- with an anti-incumbent message fairly similar to what Fiorina is throwing at Boxer. Read more »
Ariel Pink: the myth, the former solitary man, and the current group leader
There's a moment during You Think You Really Know Me, the 2005 documentary on 1970s Midwest cult artist Gary Wilson, when the filmmakers acknowledge that their subject is not necessarily as weird as his music. "I thought he would be a little bit more," says Christina Bates, coowner of the defunct Motel Records, which reissued Wilson's 1977 jazz-rock curio You Think You Really Know Me to much acclaim. Bates' voice trails off. "He's really in complete control of his image."Read more »


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Justin Bieber gave his millions of fans a proverbial wink and a smile Friday when he accepted an honor from the prime minister of Canada – in nothing but a white T-shirt and overalls.
The 18-year-old singing sensation was back in his home country to accept a Diamond Jubilee Medal from Prime Minister Stephen Harper, who wore a suit and tie for the occasion.
"Overauhls. Lol," Bieber tweeted of the incident.
Shortly afterward, to drive his message of hilarious indifference home, he tweeted a photo of himself in his full outfit, complete with a backwards baseball cap, large silver chain and yellow high-tops.
"I met the Prime Minister in overalls lol," he tweeted. "I hope you hate my style."


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HARRISON COUNTY, Ind. (WHAS11) -- It's the largest roundup ever of suspected drug dealers in Harrison County, Ind.
The arrests all took place before 5 a.m. Tuesday.
More than three dozen officers joined forces with surrounding counties to track down 33 people suspected of dealing meth, heroin, cocaine, marijuana and prescription drugs.
Mugshots of Suspects: Computer | Mobile
Deputies took 27 into custody within the first two hours of what was called "Operation N.A.S.T.I." The operation began almost a year ago, using undercover officers and surveillance video.
2012's Operation N.A.S.T.I mugshots: http://bit.ly/J28Bh6
Chief Deputy Wayne Kessinger says this roundup will not only eliminate drugs on the street, but also in the areas of major crimes.
Download WHAS11 News app: iPhone | Android
"When you do an individual, it doesn't have a big impact. What we're trying to do is send a message to people of Harrison County that, our biggest problem is robberies, thefts and burglaries and all of that is a result of a drug problem," Kessinger said.
Police hope to have all 33 suspects in custody by the end of the week.
This is the second year for Operation N.A.S.T.I., also known as Narcotics Apprehension Suppression Through Intervention.


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How to Wear Lace Front Wigsby Lynn Anders
Lace front wigs differ from standard "full lace" wigs in their construction. With a lace front wig, only the front section of the wig is made of lace, while the rest of the wig base is made of other materials. This allows you to pull the hair back without anyone noticing that you are wearing a wig, although it does take some practice to learn to apply and wear your lace front wig for the most natural look.
Items you will need
- Skull cap
- Hair pins
- Alcohol
- Cotton balls
- Skin protector
- Adhesive
Braid your hair into small cornrows or flatten your hair and cover with a wig cap. Your real hair must be as flat and inconspicuous as possible. Also, use hair pins to secure any loose hair onto the top of your head and away from your face.
Use a cotton ball soaked in alcohol to clean the skin around your entire hairline. Rub along your hairline from your forehead to the back of your head.
Apply the skin protector using a cotton ball to the skin along your entire hairline. Just as you did with the alcohol, apply the skin protector to the skin closest to your hairline around your entire head. Let dry completely.
Brush on the adhesive with the brush provided. Apply the adhesive to the skin along your entire hairline. Let this dry before putting on the lace front wig.
Put your wig hair into a loose ponytail before applying the wig. This will keep the hair looking neat and avoid getting stray hairs in your adhesive.
Roll back the front top edge of the wig as you fit it onto your head. Position the wig on your head but don't unroll the wig edges onto the adhesive until you have it positioned it the way you want it.
Roll the lace front edge of the wig over your hairline and onto the adhesive on your skin once you have the wig in the proper position. Press the edges of the wig onto the adhesive, starting at the top of your head and then moving to the back of your head and behind the ears.
Style the hair any way you choose. With a lace front wig, you can pull the hair up into a ponytail, braid or other up-do style.
- If you use a wig cap, choose a color that is slightly lighter than your skin tone.
- Use adhesive remover on a cotton ball to remove any misplaced adhesive.
- Read the instructions that came with the wig. Most manufacturers provide specific instructions for applying your wig. These may vary slightly from the standard instructions.


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Girl Scouts would also like to extend a very special
thank you to our
top Capital Campaign
donors for all of your support!
Polly and Larry Nichols
Chesapeake Energy Corp
Devon Energy
The J.E. and L.E. Mabee Foundation, Inc.
The Alford Foundation
The Chickasaw Nation
Mary Nichols
SONIC, America's Drive-In
E.L. and Thelma Gaylord Foundation
Inasmuch Foundation
Ann Simmons Alspaugh
Linda Whittington
Bronze Award Workshop
Date: September 17, 2013
Time: 6:30 - 7:30 p.m.
Place: Mary Nichols' Family Leadership Center - 6100 N Robinson Ave., OKC, OK 73118
Who: Juniors and Adults
Cost: FREE
Going for the Bronze Workshop
This session will prepare you to complete the award process and become a positive change in your community! (Bronze Award is for Juniors) This is the highest award that Girl Scouts can earn at this grade level.
Event Contact: Megan Adkins, 405-418-7963
Deadline to Register: September 13, 2013


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Authorities say a husband and wife were found dead in a plane crash in western Arkansas. Crews had been searching for the single-engine plane since it disappeared from radar on Monday afternoon.
The Civil Air Patrol says the crashed plane was located Tuesday morning in rural western Arkansas.
Madison County Sheriff Phillip Morgan says the husband and wife were found dead at the scene of the crash. Their names have not yet been released, pending notification of relatives.
The Civil Air Patrol says the plane only had two people on board. It wasn't immediately clear who owned the aircraft.
Tulsa, Okla., television station KJRH reports (http://bit.ly/1bSHtdz) that the Piper Saratoga was headed to Claremore, Okla., from Sylacauga, Ala.(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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(706) 650-5400
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EEO Report
Closed Captioning


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Share your comments
Diary of a wimpy kid : Greg Heffley's journal
Jeff Kinney
Children's Fiction KINNEY
Jeff Kinney
Children's Fiction KINNEY
What other readers are saying about this title:
MarshmallowReaders said:
I love these books.
posted Dec 24, 2012 at 1:22PM
chinu said:
its funny and awsome very cool.
posted Apr 23, 2013 at 8:46PM
Alex said:
This book was a good. I like how there is funny stuff in it, And how its so entertaining1!!!
posted Jun 4, 2013 at 11:44AM
Alex said:
This book was a good. I like how there is funny stuff in it, And how its so entertaining1!!!
posted Jun 4, 2013 at 11:44AM
minnesotakid1 said:
This book is really funny! It isn't written with normal font, instead it looks like hand writing! There are also many drawings describing his "Journal Entries." This book is SUPER funny and I would recommend it to anyone who needs a good laugh. The quiz question is even about it this week. It talks about his life through is middle school years. There are other ones but you don't need to read them in order. Once you read them you can watch the movies which are just as funny!
posted Jun 9, 2013 at 12:08PM
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Find this title in the Library Catalog
Greg Heffley
Age: 12
Starts middle school; wants to fit in and get girls; tries to use Rowley's popularity to his own advantage.
Age: 12
Greg's best friend; starts to become popular in school.


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MOSINEE, WI (WSAU) - Monday was busy for Wausau Paper staff. Along with finalizing the agreement to sell the Mosinee and Rhinelander specialty paper mills to KPS Capital Partners' new company Expera Specialty Solutions, they also released a new product in their tissue line.
It's called DublNature® and is a plush, cloth-like paper towel that utilizes 100% recycled fiber. The new towel received the Green Seal certification for its recycled fiber content, making it appealing to businesses and households that prefer to make "green" purchases.
DublNature is the first of two new product lines planned for the new high-tech paper machine recently completed in Harrodsburg, Kentucky. Wausau Paper plans to launch their new premium brand Artisan™ line later this year.
Many of the Wausau Paper products are marketed to commercial users, but some are available in the consumer retail market.


text: Homer Simpson is a man's man, an Average Joe, a loving father and husband, and a devoted beer drinker. But do you know the "real" Homer? Find out what's on Homer's mind, discover the mysteries of Homer's fridge, hang out in Homer's haunts; meet his friends and enemies; and spend a typical day with the lovable lout who will lift you out of your D'oh-ldrums.


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Your Family Vacation Guide: Fun for All Ages
A family vacation can be a wonderful diversion from the ordinary. It gives everyone the opportunity to visit new places, affords the adults a chance to take a break from their daily routine, and allows Mom and Dad to spend some true quality time with their kids. Yet, when you're ready to hit the road, how do you make sure that everyone will have a good time, especially when you have older children and a baby on board? Should you put life on hold and wait until everyone is mature enough to enjoy the same activities, or do you make the best of your current situation and go ahead with your travel plans?
Lisa Cohn, co-author of One Family, Two Family, New Family: Stories And Advice For Stepfamilies, has four children ages seven to 17 and says that having a little one along didn't stop them from going on vacations. "It was never a problem," says Cohn. "We took her to places like the Oregon Coast and Mt. Hood. When she was a baby we carried her to the beach, the pool, and the basketball court, and took turns holding her when we hiked. When she was old enough to walk, she was anxious to keep up with her older siblings, and they generally included her when she followed them along."
If you make up your mind that traveling with older siblings and a younger child won't pose a problem, the first step is to discuss all aspects of the trip with your kids. Dr. Cindy Dormer, a family communications expert and author of Hold That Thought For Kids, has three children, ages four, 14, and 17. Before her family sets off on their journey, she and her husband pull out a calendar and a map and talk about three things: when they're leaving, where they're going, and what they'll be doing once they reach their destination.
"Involving the older children is a good way of making them feel as if they are an integral part of the family," says Dr. Dormer. "Parents should also find out if the older kids have ideas about activities that would be good for the baby. If the baby stuff is their idea, they're less likely to fuss about it when it's time to do it."
The next step is to decide on how you will reach your destination. Will it be by plane, train, boat, or car? Will you arrive at your vacation spot in just a few hours, or will your trek take several days? No matter what mode of transportation you decide to use, or how long it will take, the key to making travel time less stressful for little ones and older siblings is to bring along diversions that will make your passengers happy.
Supplying "survival kits" for your children is one way of keeping them from getting bored. We know that it's important to keep babies' tummies full and their bottoms dry in attempts to achieve maximum happiness, so pile their bags with food, formula, wipes, diapers, pacifiers, clean clothes, and bottles. Bring age-appropriate toys for babies and toddlers, too.
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All Golden Valley Casino guests will be spoiled for choice when looking for Worcester activities to help them pass the time. A number of on-site activities will keep both you and the kids busy when you've had enough relaxing and want to get out and do something.
Feeling like a little bit of retail therapy? The Trading Post is a small shop within the casino that offers you the bits and pieces you may have a craving for. Grab a magazine and chocolates before heading out to the swimming pool to suntan or make sure you don't miss your morning paper. The Trading Post stocks the following goods:
Open times:10h00 – 22h00 Sun - Tue10h00 – 00h00 Wed - Sat10h00 – 02h00 Public Holidays
The Golden Valley Casino hotel offers an exceptional kids programme and holiday programmes that will have your kids begging you to return for every holiday to follow. Harry's Corner accommodates children between the ages of 2 and 17 in a special, supervised area. The barnyard atmosphere is a delight for the little children and Harry the Scarecrow is fondly featured. There are a number of activities for your kids to partake in, such as:
Children older than four years can enjoy free play in the arcade games section whereas those younger than four are cared for in the crèche where they can watch movies, paint, draw or build puzzles. Guests can rest assured that their little ones are well looked after while you enjoy some quality gaming in the casino.
Open times:11h00 – 22h00 Mon – Wed11h00 – 23h00 Thu10h00 – 23h00 Fri and Sat10h00 – 22h00 Sun and Public Holidays10h00 – 23h00 School holidays and days before a public holiday


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- Purchase any Kindle Book sold by Amazon.co.uk and receive �1 credit to try out our Digital Music Store. Here's how (terms and conditions apply)
Adrian Howell (pen name) is the author of the PSIONIC Pentalogy: five novels that follow the life of a telekinetic teenager through a dark world of warring paranormal factions, deadly religious cults and secret government organizations.
Born of a Japanese mother and American father, Adrian was raised for a time in California and currently lives a quiet life in Japan where he teaches English to small groups of children and adults. Aside from reading and writing fiction, his hobbies include recumbent cycling, skiing, medium-distance trekking, sketching and oversleeping.
If you wish to contact the author directly with any comments or questions, try:
Visit the author's blog at:


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Love, Hope, Faith, Happiness, believe, happy, joy, believe, religion, God, Christian, trust
This great custom product in red from our department Women and T-Shirt category can be printed just for you in the size and style you like. The design Love Hope Faith Happiness was created by Nowhereman78 and uploaded to Spreadshirt for you to have printed on a T-Shirt. Next to a host of other great customized designs, you can find this Love Hope Faith Happiness design in Spreadshirt's Miscellaneous category. If you are interested in topics like God or Happiness, then you'll love Love Hope Faith Happiness designs by Nowhereman78. Spreadshirt also offers a huge selection of custom t-shirts, hoodies and accessories for the category Miscellaneous as well as top Joy clothing. Nowhereman78's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your destination for great designs of all kinds – whether it's God, Happiness or Joy. We are sure that you will find something nice in our shop, there are many amazing custom Miscellaneous t-shirts, hoodies, or accessories for you to find!Tags: Design ID: 3847174
sunglasses_mustache3 Other Designed by surreal197
love to train Designed by skill11
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The Official Save the Ta-tas® Logo Other Designed by SAVETHETATAS
A mustache with a gift ribbon Other Designed by namo
Two owls Other Designed by SumuLee
Sloth Love Hug iPhone 4/4S Case Designed by carlhuber
segelschiff_o_3c Bags Designed by Judith-M83
This figure-flattering, slim fit t-shirt is soft, stylish and above all comfortable. This is the one you don't let your girlfriends borrow. It's perfect with jeans, khakis, leggings or pretty much any other bottom and is great for layering.
still to fill


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Post office customers still have until midday Saturday to ensure their gifts will arrive on or before Christmas, as weather in the Midwest threatens to snarl deliveries.
According to the US Post Office, customers using Express Mail can send packages out Saturday and still have them delivered in time for Christmas. Rates for Express Mail start at $18.95.
Although post offices will be closed Christmas Day, couriers will still report to work on Christmas to deliver Express Mail parcels.
Fed Ex reports it will not deliver to homes or businesses Christmas Eve or Christmas Day. UPS will deliver Christmas Eve but not Christmas. On-time deadlines for the commercial carries very with parcel size and destination.
Inclement weather is predicted in 17 states as a result of the Midwest's first major snowstorm of the season. Despite the weather concerns, USPS Express Mail comes with a money-back guarantee for Christmas delivery.
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- JabuJabu: Everyone's favorite fish deity/dungeon~3 days ago
Book's coming along well! Should be finishing up in the next week or two. :D Planning to release in late November.Had a lot of fun at the Fangamer PAX booth this year signing books/posters and helping out customers~ Someone had me doodle their Charizard X, Menkar, in their book.Sep 1stSee you guys at PAX Prime this weekend! I'll be at the Fangamer booth for most of the show (near the Riot booth, I think), and at the Fangamer/Attract Mode art show on Saturday night~ Please come say hi! ♥Aug 28th
https://www.facebook.com/events/576269005812524/Anyone going to PAX Prime in a couple weeks? I'll be around the Fangamer booth on Saturday and Sunday if anyone wants a book signed or a high five. ♥Aug 15thWEEKLY KANTO CONTEST GIVEAWAY: Share & tell me who your first starter was for a chance to win a signed hardcover copy of the Kanto Field Guide! I'll pick a winner tomorrow. International entries welcome!Aug 14th
Or if you just want to grab it, it's available here~:
- RT @hank_peters: http://t.co/DEmlnrkeWs NO 03:09:12 PM June 11
- Not sure if they showed this on Nintendo Direct: Legend of Zelda: A Link Between Worlds E3 Trailer http://t.co/RBDjul0SmY 03:06:58 PM June 11
- RT @dawnchapel: #atari #jaguar #dothemath 03:19:48 AM June 11
- RT @CorySchmitz: Holy crap you guys, watch this video now: http://t.co/gZFRKipiAD 02:52:31 AM June 11
- Haha, I love his smug delivery. #shotsfired #e3 02:43:29 AM June 11
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Available on RedBubble. If you like this, also check out Corgi Cluster. Coolest dogs on the planet. (Pugs are a close second.)
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New findings from researchers in NCI's Center for Cancer Research (CCR) have shown that rapamycin, an immunosuppressant normally used to prevent the body from rejecting organ and bone marrow transplants and also used to coat cardiac stents, was highly effective in preventing the development of tobacco-related lung tumors in mice.
The study results, published in the April 1 Clinical Cancer Research, showed that rapamycin (also known as sirolimus) succeeded by inhibiting mTOR, a protein known to play a critical role in the development of certain lung tumors. This study tested rapamycin for treatment as well as prevention of lung cancer.
The researchers exposed the mice to NNK, a procarcinogen found in tobacco. Those given rapamycin beginning 1 week later, on alternate days, had a 90-percent drop in the number of tumors and a 74-percent drop in tumor size. Mice given rapamycin 26 weeks after exposure to NNK continued to develop tumors at the same rate as controls; however, the tumors were smaller and did not progress as quickly.
"Our studies provide an exciting link between exposure to an important tobacco carcinogen, NNK, and mTOR," said Dr. Phillip A. Dennis, head of the Signal Transduction Section in CCR's Medical Oncology Branch. "The critical question is whether this approach would be safe and effective in smokers at high risk for developing lung cancer. Given that rapamycin is relatively inexpensive and FDA-approved for other indications, we are designing clinical trials in humans to address these questions and hope to have the answers in the near future."
Further research is needed to determine whether doses of rapamycin that achieve an antitumor effect in mice are achievable in humans, and whether giving a dose that would be sufficient for an antitumor effect would cause unacceptable levels of immune suppression or toxicity.
New Prostate Cancer Guidelines Weigh Early Therapy, Watchful Waiting
Updated guidelines from the American Society of Clinical Oncology (ASCO) on the use of androgen deprivation therapy (ADT) to treat prostate cancer state that early ADT does not appear to offer a survival advantage over so-called watchful waiting for men with metastatic or progressive disease and, as a result, do not strongly recommend this treatment approach.
The guidelines were published in the April 2 issue of the Journal of Clinical Oncology and are available on the ASCO Web site. Among the materials reviewed by an expert advisory panel to develop the updated guidelines were results from recent randomized, controlled clinical trials, a meta-analysis, a systematic review, and data from several ongoing trials.
Based on its review, the panel concluded that, although early initiation of ADT did decrease the risk of prostate cancer-specific death by 17 percent, it increased the risk of overall mortality by 15 percent and, as a result, could not be endorsed as a favored option over watchful waiting.
"Doctors should discuss with patients the risks and benefits of early ADT versus deferred therapy," the guidelines' lead author, Dr. Andrew Loblaw from Toronto Sunnybrook Regional Cancer Centre, advised in a statement. "If the patient prefers to defer therapy, he should have regular visits with his doctor every 3 to 6 months to monitor the disease."
The guidelines also state that the available evidence suggests that when ADT therapy is initiated, bilateral orchiectomy or luteinizing hormone-releasing hormones (LHRH) are the recommended options. In addition, the panel found strong evidence to back the option of so-called combined androgen blockade, in which a nonsteroidal anti-androgen therapy is combined with an orchiectomy or LHRH.


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The Saskatchewan Roughriders have acquired DE Alex Hall from the Winnipeg Blue Bombers, a move that should see their sack totals increase moving forward.
Saskatchewan sent non-import offensive lineman Patrick Neufeld and a 2015 fourth-round draft pick to the Blue Bombers for Hall and a 2014 second-round draft pick.
In his second year in the league, Hall has a league-leading 15 sacks. The East Division All-Star also has 31 tackles and three fumble recoveries.
Neufeld has started 13 of 17 regular season games he's played in for the Roughriders.
"Alex has been a great player for us over the past two seasons, however, we feel this move will be positive for the long term betterment of the football team," acting General Manager Kyle Walters said in a team statement. "We thank Alex for his tireless efforts and professionalism with us and wish him the best moving forward."
"In Patrick, we are receiving a Canadian offensive tackle who has experience in our league and who we feel can upgrade our offensive line."
Hall will become a free agent at the end of this season and will reportedly look for a deal in the NFL.
CFL on TSN analyst Paul LaPolice opens his playbook and breaks down key plays from each week's games. More...
The CFL on TSN panel is all set to answer your football questions!
Send your question on Twitter to @CFLonTSN using the hashtag #AskThePanel.


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Two men have been arrested in the attempted armed carjacking of a food delivery vehicle in Rockville, police said.
Twenty-year-old Jose Maria Deduque, of Potomac, and 21-year-old Kwajo Oteng-Agipong, of Northeast D.C., were both charged with armed carjacking, conspiracy to commit armed carjacking and motor vehicle theft, according to Montgomery County police.
Shortly before 9 p.m. Sunday, a deliveryman was heading back to his vehicle after making a delivery in the 1600 block of Yale Place. He was approached by Oteng-Agipong and Deduque, one of whom displayed a handgun and demanded the vehicle, police said.
Oteng-Agipong and Deduque entered the vehicle, but couldn't operate its manual transmission. The men fled on foot, and police K-9 units were able to locate and arrest them a short time later. Authorities also found a discarded backpack containing a black BB gun that looked like a semi-automatic pistol.


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10 U.S. Code Chapter 106A - EDUCATIONAL ASSISTANCE FOR PERSONS ENLISTING FOR ACTIVE DUTY
- § 2141. Educational assistance program: establishment
- § 2142. Educational assistance program: eligibility
- § 2143. Educational assistance: amount
- § 2144. Subsistence allowance
- § 2145. Adjustments of amount of educational assistance and of subsistence allowance
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2004—Pub. L. 108–375, div. A, title V, § 532(a)(1),Oct. 28, 2004, 118 Stat. 1896, renumbered chapter 107 of this title as this chapter.
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Summary: Granulocyte-macrophage colony-stimulating factor
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Granulocyte macrophage colony-stimulating factor Edit Wikipedia article
|Granulocyte-macrophage colony-stimulating factor
three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor
|Pfam clan
|Systematic (IUPAC) name
|Human granulocyte macrophage colony stimulating factor
|Clinical data
|Legal status
|CAS number
|ATC code
|Chemical data
|Mol. mass
|14434.5 g/mol
|(what is this?) (verify)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts.
GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exit the circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer.
The human gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Genes in the cluster include those encoding interleukins 4, 5, and 13.[1]
Human granulocyte macrophage colony-stimulating factor is glycosylated in its mature form.
Medical use
GM-CSF is manufactured using recombinant DNA technology and is marketed as a protein therapeutic called molgramostim or, when the protein is expressed in yeast cells, sargramostim (Leukine). It is used as a medication to stimulate the production of white blood cells and thus prevent neutropenia following chemotherapy.
GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising[2] but GM-CSF is not presently FDA-approved for this purpose.
Leukine is the trade name of sargramostim, recombinant yeast-derived GM-CSF developed at Immunex (now Amgen) and first given to six humans in 1987 as part of a compassionate-use protocol for the victims of the Goiânia cesium irradiation accident.[3] It is currently manufactured by Berlex Laboratories, a subsidiary of Schering AG. Its use was approved by U.S. Food and Drug Administration for acceleration of white blood cell recovery following autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma, acute lymphocytic leukemia, or Hodgkin's disease in March 1991.[4] In November 1996, the FDA also approved sargramostim for treatment of fungal infections and replenishment of white blood cells following chemotherapy.[5]
Berlex funded a study that ran in the May 26, 2005 issue of the New England Journal of Medicine, which concluded that GM-CSF did produce significantly more remissions in Crohn's disease than those having received a placebo in the study, and it also decreased disease severity and improved quality of life.[6] The study's lead author, Joshua Korzenik of Harvard Medical School and Massachusetts General Hospital, is a paid consultant for Berlex, and co-inventor of the patent, which is owned by Washington University - St. Louis.[7]
Rheumatoid arthritis
GM-CSF is found in high levels in joints with rheumatoid arthritis and blocking GM-CSF may reduce the inflammation or damage. Some drugs (e.g. MOR103) are being developed to block GM-CSF.[8]
See also
- ^ "Entrez Gene: CSF2 colony stimulating factor 2 (granulocyte-macrophage)".
- ^ Breitbach CJ, et al. (2011). "Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans". Nature 477 (7362): 99–102. doi:10.1038/nature10358. PMID 21886163.
- ^ By HAROLD M. SCHMECK JrPublished: November 02, 1987 (1987-11-02). "Radiation Team Sent to Brazil Saves Two With a New Drug - New York Times". Nytimes.com. Retrieved 2012-06-20.
- ^ "Approval Summary for sargramostim". Oncology Tools. U.S. Food and Drug Administration, Center for Drug Evaluation and Research. 5 March 1991. Archived from the original on 29 September 2007. Retrieved 20 September 2009.
- ^ "Newly Approved Drug Therapies (179): Leukine (sargramostim), Immunex". CenterWatch. Retrieved 12 October 2008.
- ^ Korzenik J, Dieckgraefe B, Valentine J, Hausman D, Gilbert M (2005). "Sargramostim for active Crohn's disease". N Engl J Med 352 (21): 2193–201. doi:10.1056/NEJMoa041109. PMID 15917384.
- ^ Bernstein DS (2006-04-12). "Med school drug pushers: How scientists are selling out to drug companies". The Boston Phoenix. Retrieved 2008-10-12.
- ^ "MOR103 - Antibody for the Treatment of Rheumatoid Arthritis, Germany". 2010.
Further reading
- Esnault S, Malter JS (2002). "GM-CSF regulation in eosinophils". Arch. Immunol. Ther. Exp. (Warsz.) 50 (2): 121–30. PMID 12022701.
- Martinez-Moczygemba M, Huston DP (2003). "Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF". J. Allergy Clin. Immunol. 112 (4): 653–65; quiz 666. doi:10.1016/j.jaci.2003.08.015. PMID 14564341.
- Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers". Clin. Chem. Lab. Med. 42 (12): 1347–54. doi:10.1515/CCLM.2004.253. PMID 15576295.
- Hamilton JA, Anderson GP (2005). "GM-CSF Biology". Growth Factors 22 (4): 225–31. doi:10.1080/08977190412331279881. PMID 15621725.
- Tortorella C, Simone O, Piazzolla G et al. (2007). "Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins". Ageing Res. Rev. 6 (2): 81–93. doi:10.1016/j.arr.2006.10.001. PMID 17142110.
- Robertson SA (2007). "GM-CSF regulation of embryo development and pregnancy". Cytokine Growth Factor Rev. 18 (3–4): 287–98. doi:10.1016/j.cytogfr.2007.04.008. PMID 17512774.
- Morales JK, Kmieciak M, Knutson KL, Bear HD, Manjili MH (2009). "GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b−Gr1− bone marrow progenitor cells into myeloid-derived suppressor cells". Breast Cancer Res Treat. 123 (1): 39–49. doi:10.1007/s10549-009-0622-8. PMC 3095485. PMID 19898981.
External links
- Official gentaur web site
- Official Leukine web site
- Granulocyte-Macrophage Colony-Stimulating Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000773Granulocyte-macrophage colony-stimulating factor (GMCSF) is a cytokine that acts in hematopoiesis to stimulate growth and differentiation of hematopoietic precursor cells from various lineages including granulocytes, macrophages, eosinophils and erythrocytes [PUBMED:2458827, PUBMED:1569568]. GMCSF is a glycoprotein of ~120 residues that contains 4 conserved cysteines that participate in disulphide bond formation. The crystal structure of recombinant human GMCSF has been determined [PUBMED:1569568]. There are two molecules in the asymmetric unit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure, which is highly compact and globular with a predominantly hydrophobic core, is characterised by a 4-alpha-helix bundle. The helices are arranged in a left-handed anti-parallel fashion, with two overhand connections. Within the connections is a two-stranded anti-parallel beta-sheet. The tertiary structure has a topology similar to that of Sus scrofa (pig) growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus [PUBMED:1569568].
Gene Ontology
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|Cellular component
|extracellular region (GO:0005576)
|Molecular function
|growth factor activity (GO:0008083)
|granulocyte macrophage colony-stimulating factor receptor binding (GO:0005129)
|Biological process
|immune response (GO:0006955)
Domain organisation
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Pfam Clan
This family is a member of clan 4H_Cytokine (CL0053), which has the following description:
Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.
The clan contains the following 22 members:CNTF EPO_TPO Flt3_lig GM_CSF Hormone_1 IFN-gamma IL10 IL11 IL12 IL13 IL2 IL22 IL3 IL34 IL4 IL5 IL6 Interferon Leptin LIF_OSM PRF SCF
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
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External links
MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.
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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
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|Seed source:
|Sarah Teichmann
|Previous IDs:
|Bateman A
|Number in seed:
|Number in full:
|Average length of the domain:
|118.90 aa
|Average identity of full alignment:
|55 %
|Average coverage of the sequence by the domain:
|84.06 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
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Species distribution
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
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Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
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For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
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The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
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Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GM_CSF domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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