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Dana M. Brantley-Sieders, Ph.D.
Assistant Professor of Cancer Biology
Assistant Professor of Medicine: Rheumatology and Immunology
VICC Member
Contact Information:
T-3107A Medical Center North
1161 21st Avenue South
Nashville, TN 37232-2681
Fax: 615-322-6248
Our research program focuses on molecular mechanisms that regulate breast tumor growth, tumor angiogenesis, and host-tumor interactions. Members of the Eph family of receptor tyrosine kinases regulate cell growth/survival, motility, and angiogenic remodeling during embryogenesis. More recently, several members of this family have been linked to tumor progression and neovascularization, including breast cancer.
Overexpression of one family member in particular, EphA2, correlates negatively with overall and recurrence-free survival in breast cancer patients.
Read more ....
Our research program focuses on molecular mechanisms that regulate breast tumor growth, tumor angiogenesis, and host-tumor interactions. Members of the Eph family of receptor tyrosine kinases regulate cell growth/survival, motility, and angiogenic remodeling during embryogenesis. More recently, several members of this family have been linked to tumor progression and neovascularization, including breast cancer.
Overexpression of one family member in particular, EphA2, correlates negatively with overall and recurrence-free survival in breast cancer patients. Our laboratory along with others has linked EphA2 signaling to Erk-dependent growth and Rac-dependent invasion in cell culture and animal models of breast cancer, as well as neovascularization and Herceptin-resistance. Moreover, EphA2 physically and functionally interacts with EGF receptor family members, including EGFR and HER2, in the context of breast cancer. More recently, we found EphA2 expression levels are highest within the Triple negative/basal-like subtype of breast cancer. Thus, EphA2 represents a new molecular target for cancer therapy, especially given its simultaneous influence on both tumor cells and the blood vessels within the surrounding microenvironment.
Ongoing studies in the laboratory focus on:
1. The role of EphA2 ligand-independent signaling in lipid metabolism in the context of breast cancer
2. The role of EphA2 signaling in Triple Negative/basal-like breast cancer growth and invasion
3. The role of EphA2 in angiocrine-mediated breast cancer growth and invasion
- Ph.D. in Cell Biology, Vanderbilt University (2000)
- Fang, WB, Brantley-Sieders, DM, Parker, MA, Reith, AD, Chen, J A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene, 24(53), 7859-68, 2005.
- Brantley-Sieders, DM, Fang, WB, Hicks, DJ, Zhuang, G, Shyr, Y, Chen, J Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J, 19(13), 1884-6, 2005.
- Brantley-Sieders, DM, Chen, J Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis, 7(1), 17-28, 2004.
- Brantley-Sieders, D, Parker, M, Chen, J Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des, 10(27), 3431-42, 2004.
- Brantley-Sieders, DM, Caughron, J, Hicks, D, Pozzi, A, Ruiz, JC, Chen, J EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci, 117(Pt 10), 2037-49, 2004.
- Schneider, C, Strayhorn, WD, Brantley, DM, Nanney, LB, Yull, FE, Brash, AR Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. J Invest Dermatol, 122(3), 691-8, 2004.
- Muraoka, RS, Koh, Y, Roebuck, LR, Sanders, ME, Brantley-Sieders, D, Gorska, AE, Moses, HL, Arteaga, CL Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol, 23(23), 8691-703, 2003.
- Cheng, N, Brantley, DM, Liu, H, Lin, Q, Enriquez, M, Gale, N, Yancopoulos, G, Cerretti, DP, Daniel, TO, Chen, J Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res, 1(1), 2-11, 2002.
- Muraoka, RS, Dumont, N, Ritter, CA, Dugger, TC, Brantley, DM, Chen, J, Easterly, E, Roebuck, LR, Ryan, S, Gotwals, PJ, Koteliansky, V, Arteaga, CL Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest, 109(12), 1551-9, 2002.
- Muraoka, RS, Lenferink, AE, Law, B, Hamilton, E, Brantley, DM, Roebuck, LR, Arteaga, CL ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol, 22(7), 2204-19, 2002.
- Brantley, DM, Cheng, N, Thompson, EJ, Lin, Q, Brekken, RA, Thorpe, PE, Muraoka, RS, Cerretti, DP, Pozzi, A, Jackson, D, Lin, C, Chen, J Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene, 21(46), 7011-26, 2002.
- Cheng, N, Brantley, DM, Chen, J The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev, 13(1), 75-85, 2002.
- Muraoka, RS, Lenferink, AE, Simpson, J, Brantley, DM, Roebuck, LR, Yakes, FM, Arteaga, CL Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. J Cell Biol, 153(5), 917-32, 2001.
- Bushdid, PB, Chen, CL, Brantley, DM, Yull, F, Raghow, R, Kerr, LD, Barnett, JV NF-kappaB mediates FGF signal regulation of msx-1 expression. Dev Biol, 237(1), 107-15, 2001.
- Brantley, DM, Chen, CL, Muraoka, RS, Bushdid, PB, Bradberry, JL, Kittrell, F, Medina, D, Matrisian, LM, Kerr, LD, Yull, FE Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell, 12(5), 1445-55, 2001.
- Brantley, DM, Yull, FE, Muraoka, RS, Hicks, DJ, Cook, CM, Kerr, LD Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech Dev, 97(1-2), 149-55, 2000.
- Muraoka, RS, Bushdid, PB, Brantley, DM, Yull, FE, Kerr, LD Mesenchymal expression of nuclear factor-kappaB inhibits epithelial growth and branching in the embryonic chick lung. Dev Biol, 225(2), 322-38, 2000.
- Bushdid, PB, Brantley, DM, Yull, FE, Blaeuer, GL, Hoffman, LH, Niswander, L, Kerr, LD Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature, 392(6676), 615-8, 1998.
- Dana M Brantley "Apolipoprotein E synthesis by transplanted bone marrow derived cells in apolipoprotein E deficient mice." BIOS, 6774-82, 1996.


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I enjoy drinking brewed tea. In my day-to-day life I consume mostly not caffeinated (not de-caffeinated!) teas from tea bags but on weekends or when having friends over I like making real tea. I'm not a tea snob, I do not read about teas even as much as I read about perfumes so I have no idea if teas that I like are amouages or britney spearses of the field. And I do not really care as long as I like how they smell, how they taste and how they look.
I knew nothing about the brand when one of my friends brought a couple of Golden Moon Tea's tins as a gift – one with White tea (with an unexpectedly for a white tea well-defined taste) and one with black tea and vanilla (they do not carry it any longer but this one is the closest to the one I tried before). If you were to apply L'Artisan's Tea for Two lightly, wait for couple of hours and then add Diptyque's Eau Duelle you would get something close to how Madagascar (black tea) smells.
For a while I could buy those teas from Williams Sonoma and several upscale grocery stores but then they disappeared. I switched to other brands but kept reminiscing about those teas… until I thought of looking for them online (I know it sounds strange now but it all happened long before the verb "to google" was added to official dictionaries). I found company's website, ordered their Tea Taster's Sampler, decided which I liked most and since then I buy those from time to time.
My current favorites (in addition to the two mentioned above) are Honey Pear (the smell of Jo Malone's English Pear & Freesia from the bottle) and Rose (the same exercise with Tea for Two and then add Jo Malone's Red Roses and start sniffing immediately before it turns soapy).
Golden Moon Tea offers a variety of teas, not only flavored as my favorites mentioned above, so if you're curious check them out. There is a promotion going on now – 15% off any purchase from their website with a coupon 15percent (exp. 4/14/2011). As somebody who follows their promotions I can confirm that this is a rare one, they have it several times a year so it might be good time to try some of their teas. S&H is $4.95 (free with $60 purchase).
Do you have favorite teas?
As always, feel free to post a link to your blog's post(s) related to the topic.
Image: my own

subset: commoncrawl


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April showers brought a fresh coat of snow blankets in the Chicago area Tuesday, making for a sloppy and dangerous commute.
The snow that started Monday evening dropped a total 1.4 inches until 1 a.m. Tuesday at O'Hare International Airport, bringing the year's snow total to 82 inches, according to National Weather Service meteorologist Matt Friedlein.
The temperature was 26 degrees at O'Hare International Airport about 7 a.m.
Many Chicagoans had to start their morning by scraping off their cars and reevaluating their outfits.
Many bikes, which are usually are sign of spring, were snow covered and icy Tuesday morning. Locals told FOX 32's Anita Padilla that they are "snover it." One man called the April snow "ridiculous."
The cold temperatures and snowfall made for an icy and dangerous commute. Officials responded to several crashes Tuesday morning. One crash on the Dan Ryan involved none cars.
No more snow is expected in the next week, and as April passes, snowfall becomes less likely, the weather service said.
The Sun Times Media Wire contributed to this story
Follow @fox32news
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This unique call is designed and produced by famed caller Mickey Saso. Its unique 8-in-1 combination includes calls for pintail, teal, widgeon, wood duck, mountain quail, bobwhite quail, gamble quail and valley quail. The 8-in-1 call features an easily adjustable slide to allow for quick tuning adjustments.
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A firefighter has been terminated for having sex while on the job at fire stations, the department said Friday.
Joel H. Mitchell, 28, was fired after a department investigation and disciplinary hearing, said Deputy Chief Kim Lawson.
The president of the local firefighters' union said they plan to appeal the decision.
A complaint first surfaced in December 2013 when a citizen accused Mitchell of engaging in sexual activity while temporarily assigned to Station 36 in Old Hickory.
The citizen also said Mitchell had sex at Station 3 while it was located in the old Fire Marshal's building in East Nashville, according to a disciplinary letter sent to Mitchell.
An investigation found the consensual sex happened while Mitchell was on duty, violating several policies including rules against sexual activity in the workplace and allowing visitors in the dormitories.
A panel met Feb. 11 and Mitchell was found guilty of all charges and fired immediately. He has the right to appeal the decision before the Civil Service Commission within 15 days, Lawson said.
"The investigation of Firefighter Joel Mitchell shows no evidence of wrong doing at any fire station," said Mark A. Young, president of the International Association of Fire Fighters Local 140.
"No evidence was presented that would warrant termination. We do not condone this type of activity," Young said.
"However this is nothing more than a case of revenge. We have started the appeal process and strongly believe this will be overturned."
Mitchell has been a Nashville firefighter for six years.
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Bumped: Arrested for walking my dog at Al-Quds Day Rally... The Video
Upperdate: Militant Khomeinist Muslim At Center Of Al-Quds Day Dog Walking Incident Brought Hezbollah Flag To Rally
Update: The subject of this report has received his 1st threatening phone call; "We are going to kill you, you dirty jew"
Toronto Police Services Arrest Man For Walking His Dog On Al-Quds Day
It's touching how O' Canada is being sung in the background as this event unfolds.
"I was arrested at the rally for, "offending Islam" by walking in a PUBLIC park with my dog. Apparently, Muslims do not like dogs. I was warned by a few demonstrators not to go near them. Of course I ignored them and reminded them this is Canada, not Pakistan. Well I was assaulted and returned the favor in kind.


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- 866-722-3338 General Information
- 800-874-PACE Admissions
- New York City
- Westchester
|Select the desired Level or Schedule Type to find available classes for the course.
|HIS 113CG - The American Experience: The United States and the World (CAP) - Learning Community
New Core: Fulfills 3 credits in Area of Knowledge II.
Course Description: This Learning Community focuses on the international crisis that America faced during the twentieth century. Special emphasis will be placed on the World War I, World War II, and the Cold War. Students will read a variety of historical, literary, and non-fiction works in these courses. These readings will be enriched by films and taking at least one out-of-classroom field.


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Blue Book® Suggested Retail Value
Fuel Economy (city/hwy)
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User Reviews
The community thinks...
Fun to drive by Gman on 10/23/2006. Trim: 1999 Audi A6 Avant Quattro, Owned 7 years.
Pros: Styling fit and finish is beautiful. Handling and ride is great. Quattro is felt even in dry weather handling.
Cons: Just problems, the same ones over and over again. For example I have replaced the passenger window regular 4 times, the a/c control module 3 times, both upper front and rear control arms 3 times or more. replaced tensioner seals 3 times and its leaking again. Driver headlamp assembly 3 times, oH and how about the window washer pump or reservoir 3 times and its leaking again. Auxillary fan and the control. Each of these jobs O rings when not in warranty are a min of 1K control arms are $750 a set. Let put it this way, my extended warranty company hates me to the tune of over 10K, and I've paid at least 5K on repairs that they didn't cover durning and when the warranty ran out.
Overall review: BTW brake jobs are $500 an axle and they last about 25K miles if I'm lucky. Really a wonderful vehicle to drive if only it didn't thousand dollar you to death. Also I forgot to mention its a little poky with only 200hp and nearly 4000lbs that is what you would expect.
Review ID: #500339 Is this review offensive?


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Allover Nighttime Lotion
Mix together the oils, lecithin, and beeswax in another glass measuring
cup. Place the oils-wax mixture in a glass cup in a water bath. Heat the
oil mixture in the water bath over medium heat until the beeswax is
melted, stirring occasionally.
When the wax is melted, bring the soda-water mixture almost to boiling.
Remove the oil mixture from the water bath. Slowly add the oil mixture
to the water solution, stirring briskly.
Pour the lotion into a clean container with a lid. The lotion will
thicken as it cools. Cool completely then use this lotion all over
your body.
HomeUpAlligator Pear LotionCalifornia Cold CreamSkin CreamYarrow LotionUltra-Rich Skin CreamRose Cleansing CreamStretch Mark CreamBasic Cold CreamRose LotionRich Moisturising CreamOriginal Greek Cold CreamBody ButterMint Body LotionLanolin CreamHealth Nut LotionEnglish Ivy Body MassageDaily Hand CreamCucumber Cold CreamCream PolishComfrey Nourishing CreamChapped Hand TreatmentAustralian Frangipani LotionAlmond Oil LotionAllover Nightime Lotion


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Easton Place
"Thank you for making my vision a reality. Lauren did an amazing job of taking my requests & feedback and designing a website that was exactly as my minds eye envisioned. Chris was absolutely incredible throughout the programming and product adding process. He quickly addressed every question I had (and I had several) going above and beyond my expectations. I really felt like I had someone by my side when bringing it all together.
Isa's marketing guidance was a tremendous help for focusing on the overall plan and layout of my shop. Her insight and knowledge was outstanding.
The feedback I've received from so many people has been overwhelmingly positive. Clients and friends tell me my site is easy to use, a pleasure to shop and inspiring. I sincerely could not be happier with the final outcome.
Thank you for all your hard work, patience and vision. I highly recommend you and your team of talent."
Patti Wunder


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By Kate Ward, Hollywood.com Staff
It's a good sign that Adam Levine starred in ""The Stand Off"", the sole highlight of Jeremy Renner's Saturday Night Live episode that featured Maroon 5 as musical guest. But it's also not such good a sign that the majority of jokes in Levine's promo for his hosting gig Saturday centered around The Voice.
Granted, the swivel chairs and supple chest of Christian Aguilera lend themselves to plenty of Voice-related humor. But fans of Levine, who watched the Maroon 5 frontman dabble in drama on this season of American Horror Story: Asylum, are curious to see how the burgeoning actor fairs in other genres. Can he do comedy? Based on his Voice zingers, yes, he can. But is it too much to ask for some non-reality TV material?
In fact, the funniest part of the promo comes when Levine criticizes cast member Bobby Moynihan's ""Drunk Uncle"" character. ""Sober uncle would be just as funny, with a better message for the kids,"" Levine deadpans. Stick to this material, Adam for once, we don't want to hear about your Voice.
See the promo for the episode which features Kendrick Lamar as musical guest below!
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Jennifer Lawrence on 'SNL': Did the Actress Hit a Comedic Bullseye?
Adam Levine to Host 'Saturday Night Live'
Adam Levine: From 'The Voice' to the Big Screen
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Student project could lead to official state oysterFriday, February 14th, 2014
Nobody was really talking about designating an official "Washington state oyster" until 14-year-old Claire Thompson came along. Now the state Senate has approved a bill, on a 47-1 vote, to list the Olympia oyster as the state's official oyster.
Claire is an eighth grader at Olympia's Nova School, which requires a yearlong project involving something that students care deeply about and can make a difference. Claire, who hopes to become a marine biologist or oceanographer, developed a sense of history for the once-prominent Olympia oyster, as we learned from her testimony before the Senate Governmental Operations Committee.
The full testimony on SB 6145 falls between 40:00 and 51:00 in the video on this page.
"Pollution near historic beds caused many closures of the fishery and rallied the oyster farmers to fight for the earliest pollution control regulations for clean water and cleanup," Claire told the committee.
Ostrea lurida, the scientific name for the Olympia oyster, is the only native oyster to the region. The Pacific oyster, imported from Japan in the 1920s, makes up most of the production today, but the tiny Olympia is making a comeback as a unique delicacy with natural ties to the region.
Claire talked about ocean acidification, caused by excess carbon dioxide in the atmosphere, and its ongoing threat to the ecological health of Puget Sound, Hood Canal and other bays and estuaries.
"Ostrea lurida," she said, "stands as a living symbol of Washington's history, from the earliest Native Americans through the pioneers down through statehood to the present day, deserving protection as our native oyster. Please join me in fighting to protect not only our native oyster but our waters as well."
Claire is the daughter of Rowland Thompson, lobbyist for Allied Daily Newspapers of Washington, who encouraged her to develop her project and speak before the Legislature.
Jim Jesernig of Pacific Coast Shellfish Growers Association said he supports the bill, even though it came as a surprise to his group.
"We have been very pleased working with Claire," Jesernig said. "It's very interesting. From the industry, we did not see this. We were working on derelict vessels and a whole bunch of things going on. Claire has worked with folks in Willapa Harbor and the South Sound. We would like to support this in any way."
If next approved by the house, the Olympia oyster will become the official state oyster, joining:
- The orca, the official marine mammal;
- The Olympic marmot, the official endemic mammal;
- The willow goldfinch, the official bird;
- The steelhead trout, the official fish; and
- The common green darner dragonfly, the official insect.
By the way, Puget Sound Restoration Fund, a nonprofit group, has been working for years to restore the Olympia oyster to Puget Sound. I first wrote about this issue in 1999 in a piece called "Native oyster making a comeback — with help." A companion piece about the taste of the little oyster was titled "Olympia Oyster Gains Respect." I also presented the tribal perspective in "Tribal Officials Welcome Oyster Restoration."
Since then, Puget Sound Restoration Fund has helped rebuild native oyster populations in many bays, with one of the greatest successes in Liberty Bay near Poulsbo. Betsy Peabody, executive director, told me this morning that her group has great hopes for success in Dyes Inlet near Silverdale and in Port Gamble Bay in North Kitsap. A new oyster hatchery in Manchester is expected to be in operation later this year.
Washington Department of Fish and Wildlife has developed a long-term restoration plan for the Olympia oyster with 19 areas listed for habitat restoration:
Drayton Harbor
Bellingham Bay (South) Shoreline, Portage Island, and Chuckanut Bay
Samish Bay
Padilla Bay
Fidalgo Bay
Similk Bay
Sequim Bay
Discovery Bay
Kilisut Harbor
Port Gamble Bay
Quilcene Bay
Union River/Big and Little Mission Creek(s) deltas
Liberty Bay and sub-inlets
Dyes Inlet and sub-inlets
Sinclair Inlet
Point Jefferson-Orchard Point complex of passages and inlets
Budd Inlet
Henderson Inlet
Harstine/Squaxin Islands complex of passages and inlets


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Taylor Swift 's long list of boyfriends, both confirmed and unconfirmed, includes Joe Jonas , Jake Gyllenhaal , John Mayer and Taylor Lautner . Since none of those romances have ended well, why does Taylor continue to get involved with famous men? Well, she has her reasons, which she reveals in the new issue of the U.K. edition of Marie Claire .
While Taylor agrees that she does have track record of dating and breaking up with high-profile men, she tells the magazine, "I think I have to trust that you end up with the person you're supposed to end up with, and that everything in between is there to teach you stuff. Plus it makes for great stories when you're older."
Not only that, but it makes for great songs now. Many of Taylor's songs were written in reaction to her romantic ups and downs, and she tells Marie-Claire that she makes no apologies for it.
"Music is absolutely everything that I am and everything that I stand for. It's not my fault if someone gets into a relationship with me and then cheats and I write a song about it," she says.
Also in Marie-Claire , Taylor talks about her hopes for children in the future. She says, "I want a bunch of them running around, minimum four. I want to wait a while, but the idea of pouring everything you are into another person when you become a parent has always been amazing to me."
The singer says she's being careful with her millions now to make sure her kids will never have to worry.
"'That money will be really good for sending my kids to college some day -- or maybe I'll have a few more kids than I thought," she tells the magazine.
In addition, Taylor says that unlike many young stars, she's even considered what her kids might think about her one day, and she tailors her actions accordingly. "That factors into everything I do. They're going to have computers and they're going to be able to read what I said in this interview," she notes.
Copyright 2012 ABC News Radio


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Definition of cacophonous in English:
cacophonousSyllabification: ca·coph·o·nous
Pronunciation: /kəˈkäfənəs /
Involving or producing a harsh, discordant mixture of sounds: the cacophonous sound of slot machines
More example sentences
- Together, her many voices create for the reader a symphony, discordant thought not cacophonous, of her being.
- He twists and turns in his efforts to get away from the cacophonous dissonance, and then untwists himself to get out of his sheets.
- But the distortion is kept to a minimum as they reach for different tools to hit dizzying new heights, creating cacophonous peaks only to expertly let the moments implode into stark, hypnotic introspection.
noisy, loud, ear-splitting, raucous, discordant, dissonant, jarring, grating, inharmonious, unmelodious, unmusical, tuneless
Definition of cacophonous in:
- The British & World English dictionary
- The English Synonyms
- The US English Synonyms
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Word of the day bouffant
Pronunciation: bo͞oˈfänt
styled to puff out in a rounded shape...


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Into the 21st Century
Bob Fritz, Animal Naturals
When I began at UNIPRO in 1982 as the first employee, sports nutrition was in its infancy. 16 years ago, there were basically weight-gain powders, protein powders and liver tablets for athletes. Although in time little UNIPRO--and Champion Nutrition which grew out of it--would literally revolutionize sports nutrition with breakthrough products, it was slim pickings compared to now. The idea back then that sports nutrition could be a legitimate alternative to anabolic steroids was not taken seriously.
In 1981, a friend of mine, Mike Zumpano, who owns Champion Nutrition, wrote a book called The Underground Steroid Handbook. He and I have worked on products together like Carboplex, Cytomax and others since 1983. In 1986, Mike invented Metabolol which I first introduced to fanciers in 1987, and which I based my original PEAK PERFORMANCE on in 1989. Because of Mike's book, and that of the very bright Dr. Wright's academic steroid books, the idea of steroids as powerful drugs became more widespread, as did the belief that nutrition was pixie dust compared to these drugs.
The term "natural" became a code word for losers. The proof was clear. In drug-tested lifting meets, 20% drops in performance were typical, as was a 15-foot drop in the throwing events (discus, etc.) And as for bodybuilders, it was drug-free boys against the steroid-aided men. This reinforced the idea that only when taking steroids could athletes compete in the fast lane. In time, this mind set crept into dog sports. But a growing stream of research from elite exercise physiologists from around the word--especially the former USSR--is changing the "only steroids work" mind set. It turns out 13 years and thousands of studies later that there are real, honest alternatives to anabolic steroids. 1995, in particular, has offered major new advances.
Real Nutritional Advances The 1980's were the predigested decade, the Golden Age of sports nutrition when more major advances occurred than at any other time. The merits of predigested nutrition in sports medicine are well documented: 100% efficiency, no GI distress, etc. UNIPRO was the unquestioned leader here.
UNIPRO introduced all new at the time predigested calorie forms of protein (Amino 1000), carbohydrates (Carboplex) and fat (Lipoplex). These were landmark advances that enabled dogs to quadruple usable energy intake, while raising performance and recovery like never before. These landmark products, and the dozens of copycats based on them by knock off companies, can be found in almost any gym or health food store, almost anywhere in the world. I've even seen them in Guatemala. Other major innovations at UNIPRO were branched-chain amino acids, liquid DMG, and more.
Later, with Champion Nutrition, we developed the first lactate polymers--Cytomax, which are very important because it is the first and only sports drink that is actually research-proven to reduce lactic acid during workouts. It builds upon what we learned with Carboplex. The 1990's became the decade of non-calorie ergogenic nutrients, many of which were not new at all but recycled from UNIPRO. For example, Creatine supplements are the rage now for human athletes and for good reason--they're very effective at increasing performance and recovery. They work even better on dogs. To read the ads, you'd think Creatine just came on the scene. Not so. UNIPRO had a product called CREATINE 1500 in 1984, as fanciers who purchased this fine formula back then will remember. But because we were the only company with a Creatine product, it did not get the attention it deserved. Being the pioneer means you get overlooked, after which the bottom feeders come along and take credit more often than not.
The 90's also became a time of developing highly successful strategies to utilize the many powerful nutrition weapons developed since the 80's, thereby producing the rare 1 + 1=3 effect of nutritional synergism. Dr. Fahey, Dr. Brooks, Dr. Silber and others have led the way in this important area.
Anabolic Steroids Some swear at them, some swear by them. There's always strong views when steroids come up, often based on myths from a guy who heard from a guy who heard from a guy about what happened to his cousin's dog while on the drugs. Setting aside the stories and exaggerations about these drugs, steroids--like all other substances that affect canine metabolism--should be viewed as a tool. No magic here. A very powerful tool, with the power for both significant benefits and negative side effects. But just a tool. Steroids, if used in an overall strategy based on sound science and proven methods, can increase performance and to an ever greater degree, recovery. Used willy nilly, they often hurt more than help. To add confusion, most steroids today are counterfeit; probably 98% of them, especially mail order ones. Steroid marketers spend money to exactly duplicate drug lab's labels, not the drug inside the bottle. They don't get rich selling steroids; they get rich selling counterfeit steroids. Ferrari Testarossa rich. Wake up.
Anabolic steroids are synthetic (man made) forms of the male hormone testosterone. Developed by the Germans in the 1930's, steroids were brought to America in 1964 by Dr. Ziglar who saw the performance increases Russian athletes got from them. The Russians have done more research into steroids for athletes than all other countries combined. They have literally written the book on steroids by Dr. Yakoblev, and others.
Steroid Alternatives There are several dozen documented benefits of steroid intake, along with a long list of negative side effects. Of the benefits, we'll take the top 5 generally agreed to be the most measurable, and compare them to the latest research on the new nutritional substances now available. How well do they stack up against steroids? We examine each nutrient and give a percentage of the benefit that the nutrient can reproduce relative to steroids. At the end, we'll add it all together and get the big picture of nutrition vs. steroids. You might be surprised.
1) Nitrogen Balance (NB): This refers to the protein status of the body and is used extensively on both humans and dogs. Nitrogen balance tests are used to rate the effectiveness of steroids; the "anabolic index" of steroids is based mainly on nitrogen balance tests. NB is also used to evaluate and grade the biological value, net protein utilization and other measurements of proteins and amino acids. To have a positive nitrogen balance is the goal. In this state, the dog or human takes in more protein than they lose and they are anabolic. Steroids are known to induce positive nitrogen balance and are very anabolic in that way. But there are now strategies for inducing positive nitrogen balance without steroids that are also very effective.
The first factor to drug-free positive nitrogen balance is to take in higher quality proteins and amino acids. By far, the most effective is a new generation of milk proteins called filtered whey (milk protein) hydrolysates, close cousins of the first UNIPRO amino acids. This is whey which is partially predigested to enhance uptake and highly filtered to remove allergens and lactose, but which still has the important beta-albumin factors.
These whey amino acids are at least 350% more expensive than even the best current canine proteins. But it's worth it since they're much more efficient than even eggs, the previous gold standard. Second, have the dog retain more of the protein-nitrogen taken in, essentially what steroids do. This can now be accomplished by taking Beta Ecdysteroids, which are natural plant sterols repeatedly demonstrated to increase muscle repair and growth in both humans and dogs. Diosegenin, Creatine monohydrate, real Siberian Ginseng, and related nitrogen retaining factors are also proven to be effective in dogs.
Finally, feed all these nitrogen enhancing substances with the new generation of carbohydrates that are cleaner burning, and 20% more efficient at supplying muscle energy and facilitating amino acid entry into muscle cells.
Degree to which substance duplicates specific steroid effects: 65%
2) Cortisol Suppression: The stress hormone cortisol has received a tremendous amount of attention the last few years in the better fitness magazines. With good reason-it's been learned that cortisol, which rises during hard workouts, is an extremely catabolic (muscle destroying) hormone that's chiefly responsible for overtraining. The harder, longer and more often the workouts, the more cortisol produced, the more muscle broken down in a destructive cycle. This is why over trained dogs often look like concentration camp inmates--their muscle tissue is literally being eaten from within because the body turns on itself during very stressful times like conditioning periods.
It's now clear that elevated cortisol levels are the greatest factor leading to overtraining; not energy shortages in muscles and liver which have been largely solved with predigested calories.
One of the primary reasons that steroids are so effective in increasing performance and recovery is because they have a suppressing effect on cortisol. Although it's slight--about 5%--lowered cortisol levels from steroid intake is a major factor why steroids work. In what may be one of the more important advances in sports nutrition history, an all-natural, safe and incredibly effective substance has been discovered by APRL that lowers cortisol to 50%. And it's been tested on dogs and shown to be equally effective. This substance is called phosphytdylserine, PS for short. PS effectively reduces cortisol levels to a degree not achieved even with drugs. So when dogs work out very hard, PS tricks their body into not producing as much cortisol. Enough cortisol is still produced to carry on its roles in the body. The bottom line is this-- harder, longer, more frequent workouts and faster recovery--without overtraining. The result is a stronger, leaner dog with much better endurance--the Holy Grail. But these increases only occur IF the dog is receiving the other nutrients and strategies defined in this article. In other words, to get the full PS effects, take it as part of an overall strategy. PS will show up in many human products under many names this year because it's safe, natural and solves the age-old problem of cortisol syndrome. But remember you saw it here first for dogs.
Degree to which substance duplicates specific steroid effects: 100% +
3) Muscle and Liver Glycogen: Glycogen is the storage form of carbohydrates and supplies much of the energy during workouts. Glycogen is stored in two main tissues: muscle and the liver. The greater the glycogen content in the canine body, the greater the endurance capacity and the faster the recovery. Until the last decade or so, dogs suffered from chronic low glycogen levels because it was virtually impossible to get enough carbs into them. The advent of Carboplex largely solved this because just one cup equals about 5 cups of barley or cooked rice with zero GI distress and 100% utilization. Carboplex-type products help dogs to essentially carbohydrate load throughout the 24-hour day. Second generation Carboplex-type products (MetaCarb III, K-9 Carb II) are even more beneficial to dogs. They contain carbs that are cleaner burning and produce less lactic acid, and are much more efficient at refilling muscle and hard to fill liver glycogen.
Degree to which substance duplicates specific steroid effects: 65%
4) Phosphocreatine (PC): Muscle Stores PC is a very important fuel source in muscle tissue, supplying muscular energy during the first 8-40 seconds of intense contraction. PC stores are also very important during workouts because they are converted into ATP--the chemical currency of the canine body.
After workouts, the PC levels in muscle determine the rate of recovery and repair. Obviously, having high PC stores is an advantage to the canine athlete. Anabolic steroids are known to increase PC stores; another one of these powerful drugs' benefits.
Can taking Creatine orally actually increase the amount in muscle, and therefore performance and recovery? Yes, and it was first proven in 1928--on dogs! Just one teaspoon (5 grams) of 99% pure Creatine monohydrate is equal to the amount of Creatine found in over two pounds of prime red meat steak.
It's not surprising that Creatine supplements are very popular today. A second-generation Creatine supplement is about to hit the streets by the time this article appears. It consists of standard pharmaceutical-grade Creatine monohydrate, plus glycol simdes that enhance overall Creatine efficiency by 25%--a great deal since only about 20% of Creatine monohydrate is absorbed orally.
Degree to which substance duplicates specific steroid effects: 65%
5) Mental Focus/Aggression: Steroids create a specific chemistry in the brain, which stimulates aggression and attitude. These traits help in getting a dog's "mind right" for grueling workouts. Those who have taken steroids themselves know this feeling well. As of now, natural supplements can reproduce little of this steroid effect.
Degree to which substance duplicates specific steroid effects: 2%
Bottom Line So there's mixed results. Some substances, like PC, exert positive effects as good or better than steroids. However, this is very rare. Taken in sum, the new generation of nutrients can probably reproduce a little under 50% the benefits of steroids, a quantum leap ahead of just a decade ago. If 50% doesn't sound like much, then you've been sleeping or are stupid. It's a game of inches for human and canine athletes where even a 3% increase in performance often determines success, or failure-even a world record. It should be noted that this 50% figure is most likely attained when all nutrients are taken together within an overall strategy vs. being taken alone. Those of you who have followed the evolution of scientific nutritional products for dogs, beginning in the early Amino 1000 and Carboplex days of UNIPRO have seen it evolve into Metabolol to Metabolol II and later K9 Super Fuel.


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With over 60 years of collective experience, our professional team is committed to "a celebration of life" in a time of loss. We offer compassionate care from start to finish. Heald & Chiampa is committed to our community and to providing meaningful tributes to bid farewell to loved ones. We also pride ourselves in helping you through the healing process that follows a loss.
The historical Sumner House offers a place of warmth and solace, and our team provides a level of expertise that will allow you to make informed decisions that honor your loved one in the unique way you choose. We also specialize in helping you plan ahead to ensure that you and your loved one's needs are met when death occurs. For more information, please contact us at 508-842-3700, email to firstname.lastname@example.com to arrange a personal consultation.


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Learn more
- Product support
- TS7700 data sheet (783KB)
- Demo: TS7700 3D product tour
- TS7700 SEC Compliance Assessment White paper (663KB)
- System Storage® Interoperation Center
- Financing options
- Gain innovative data protection and business continuance for IBM® System z® servers
- Keep data secure, continuously available and easy to manage
- Improve the performance of backup and recovery operations
- Support disk or physical tape
To effectively protect data, deliver uninterrupted data access, address regulatory requirements and archive business data, organizations need a solution that can manage both primary and backup data that is active, inactive or even archived. As data centers and the data they store continue to grow, data protection often becomes more complex. This may include moving more primary data to tape, continuous backup, multiple metro and global sites, simplifying offsite recovery, disaster recovery verification, and many other objectives and processes to ensure an enterprise level of business continuance. This growth in complexity can in turn lead to higher data management overhead and costs.
IBM Virtualization Engine TS7700 comprises a family of mainframe virtual tape solutions that optimize data protection and business continuance for System z data. Through the use of virtualization and disk cache, the TS7700 family operates at disk speeds while maintaining compatibility with existing tape operations. The TS7700 family of System z tape virtualization is offered in two models:
- IBM Virtualization Engine TS7720 contains only virtual tape drives creating virtual tape volumes within disk cache to provide high performance access for workloads that have the most demanding write and recall requirements. Virtualization Engine TS7720 features encryption capable high-capacity cache using 3 TB SAS disk drives with RAID 6 providing the ability to scale to very large capacities with the highest level of data protection.
- IBM Virtualization Engine TS7740 not only stores data on virtual tape volumes within a disk cache, but also writes data by policy to physical tape. It attaches to and leverages the performance and capacity of IBM System Storage® TS1140 and earlier IBM 3592 model tape drives installed in IBM System Storage TS3500 Tape Libraries. This fully integrated tiered storage hierarchy of disk and tape takes advantage of both tape and disk technologies to deliver performance for active data and best economics for inactive and archive data. This model combines tape and disk to provide a flexible, policy-managed configuration that offers the benefits of both types of storage. Virtualization Engine TS7740 features encryption capable 600 GB SAS drives with RAID 6 protection.
Common features
- May be attached to supported IBM System z servers
- Maximum 4,000,000 virtual volumes
- Maximum of 1,536 virtual drives in a 6-way grid configuration
- Web-based management tools
- Advanced policy management
- IBM TS3000 System Console
- Synchronous mode copy
- Remote-mount IP link failover
Hardware summary
Contact IBM
- Request a quote
- Email IBM
- Find a Business Partner
Call IBM: 1-866-883-89011-866-883-8901
Priority code: 101J413W
Browse System Storage
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Jack Henry & Associates PPS speeds through two billion transactions annually with DS8000 and TS7740
IBM celebrates Tape's 60th anniversary
IBM continues to push the boundaries of tape storage systems technology


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Library Services: About
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The mission of the library is to support the college curriculum, to meet the research and information needs of the college community, to promote information literacy and life-long learning, to provide instruction in the use of library resources, and to encourage leisure reading and listening.
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To perform a search, enter a keyword, phrase or item number in the search field and click "search."
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Bright pink, this wine stands for Australian sunshine, and warm days by the beach. Vibrant raspberry and cherry aromas combine with fresh fruit salad and lovely crispness on the palate.
A dry finish lends the wine to food, matching any grilled fish or meat and the juiciest tomato basil and mozzarella salad, dressed with balsamic vinegar and extra virgin olive oil.
The Angove family company, Angove's Pty. Ltd., ranks among Australia's largest privately owned wine companies and stands as one of the few with strong interests in distilling as well as grape growing and winemaking.His early experimentation with vines, winemaking and distilling, led to the establishment of a proud family business. Dr. Angove's initial plantings at the township of...Read More About Angove Family Winemakers
Rose(roe-ZAY) A Rose by Any Other Name Technically, a rose is an unfinished red wine, but the term seems so- secondary. Rose is a different sort of wine, with all the refreshing qualities of a white wine mixed with some characteristics of a red. It can be made from many different grape varietals and in many different regions, the most popular and successful being Southern France,...Read More About Rose
Ship on us for a month!
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Roomy zippered compartments, inner pockets and side water bottle pockets make this Wildkin girls' backpack perfect for toting homework and more. In pink/multi.
Product Features
- Interior utility pockets
- Adjustable shoulder straps
- 600-denier construction
Product Details
- 17"H x 12.5"W x 7.5"D
- Ages 8 years & up
- Polyester
- Zipper closures
- Spot clean
- Manufacturer's 1-year limited warranty
- Model no: 32087
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The links below are ads provided by the Google AdWords™ program. Outside companies pay to advertise via these links when specific phrases and words are searched. These ads are provided by Google and are labeled as sponsored links. Clicking on these links will open a new tab displaying that respective company's own website. The website you link to is not affiliated with or sponsored by Kohls.com


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CORYDON, Ind. (AP) — When a group of expert cavers crawled into a remote section of the Binkley Cave system beneath southern Harrison County in fall 2010, they discovered more than an uncharted cavern.
They found the remains of ancient visitors.
And the collection of well-preserved skeletons — including snakes, a black bear, owl and juvenile bison — constitutes "one of the largest and best preserved deposits of Ice Age bones yet discovered in Indiana," said Ron Richards, chief curator of science and technology at the Indiana State Museum in Indianapolis.
Black bears clawed at the walls, and peccary — a relative of the European pig — left visible tracks, which scientists say is rare.
The bones, which include teeth, legs, skulls and several nearly intact skeletons, jut from brown clay in dozens of locations, and are remarkably well-preserved. The remains have not been carbon-dated, but scientists estimate that they are at least 12,000 years old and possibly up to 50,000 years old.
"They have something really unusual," Missouri-based paleontologist Matt Forir, who has visited the cave, told The Courier-Journal in Louisville, Ky. (http://cjky.it/Zm6QgS ). "They have a cave full of bones that tell a really neat story."
Gary Roberson, the former co-owner of Marengo Cave, his wife Laura and two other partners are working to open part of the cave system — the 11th longest nationally — as Indiana Caverns and begin offering public tours in late May.
Both Forir and Richards made separate forays into the cave last summer at the owners' request, and both found evidence suggesting that various animals, including more than 100 peccary, wandered into the underground maze up to 15,000 years ago and got lost before an Ice Age closed the entrance.
In one location, animals navigated a passageway to a ledge and then evidently lost their footing and fell 30 feet to their deaths, Richards said. Other more sure-footed animals were able to climb down rocky outcroppings, and remains that were found elsewhere suggest that bears, peccary and smaller mammals reached a lower passage where a stream still runs through the cave.
Several bear beds, or wallows, have been identified, Roberson said.
What jumped out at Forir was the well-preserved condition of peccary in several locations, which is rare. "In the fossil record, you don't normally get fully articulated skeletons," said Forir, director of the Missouri Institute of Natural Science and a professor of speleology at Drury University in Springfield, Mo.
After a second trip to the cave last month, Richards estimated that Indiana Caverns ranks as one of the top peccary caves because there may be up to 200 skeletons represented. That's nationally significant, he said, adding that they may eventually find that "it's one of the better peccary caves anywhere."
Other "bone caves" feature mastodons and mammoths. Kentucky's Mammoth Cave, with its archaeological remains of prehistoric humans, isn't known for its animal bones, despite the discovery of remains of an extinct bat species, Richards said.
In Harrison, all bones are staying in the cave because scientists have cautioned that removing skeletons from the consistent temperature and humidity of the underground environment could do irreparable harm.
But Roberson said he and crews working to create safe walkways for cave tour visitors found that moving some bones has been unavoidable. In recent months, after drilling an entrance and preparing to pour concrete footers for an elevated walkway, they discovered loads of bones buried inches beneath the clay silt.
State and federal law doesn't protect paleontological finds in the same way as archaeological remains, so property owners are free to do what they want with such remains, Richards said.
Roberson said the owners intend to conserve the environment and avoid disturbing any bones unnecessarily, but he added that spending money on any research is taking a back seat to getting the business open.
Still, at cave experts' direction, they excavated around bones that were in the way and loaded them with large chunks of mud into plastic tubs that have remained inside the cave, Roberson said.
During a short trek into the cave on a recent morning, Roberson hiked back along a newly erected metal walkway into the dark reaches and returned — his headlamp shining — carrying a small plastic tub of bones.
The bones were caked with thick clay, but the shapes of teeth, ribs and leg bones were unmistakable.
Because the trove of bones holds "tremendous value in the interpretation of the Ice Age in Indiana," Richards said, he hopes that the state and the cave owners can collaborate to preserve the bone deposits for research and education. It could cost a minimum of $10,000 to pay a scientific team to conduct an extensive dig and have material radio-carbon dated.
Roberson said the owners hope to find grant money to help pay for scientific research at the site. He declined to disclose how much the partners are paying to develop the cave for touring.
"It's an unbelievable blessing to be the caretaker of something like this," said Carol Groves, Roberson's sister and the cave's new marketing director. "It's a privilege."
Richards said it would be ideal to map and assess all of the deposits, excavate for more remains and conduct radio carbon-dating.
He said there's tremendous potential for scientists to examine micro fauna, or minute bits of bats, mice, snakes, shrew and salamander, buried in the sediment because those animals exist today.
Because scientists know those animals' range and the environmental conditions they tolerate, the bones can offer clues about the conditions they survived during the Ice Age. That's not possible with extinct animals such as the peccary, Richards said.
Binkley Cave has been a popular destination for serious cavers for decades, but members of the Indiana Speleological Survey made a big breakthrough in early 2012 when they connected two known sections of the cave system, extending its length to 35 miles.
The explorations charted a clear path to a large room that the society named Big Bone Mountain, an area that also features a 50-foot waterfall. Because all of the entrances were on private property, Roberson — who helped develop nearby Squire Boone Caverns as well as Marengo Cave, which is in Crawford County — found three partners and bought 10 acres west of Ind. 135 to open the cave, which is four miles south of Corydon.
They drilled an entrance last summer to provide quicker access to Big Bone Mountain and have been working since to install lighting, walkways and a dam to allow for short underground boat rides.
An interpretive center is under construction now where visitors will be able to walk from a ground-floor room into the cave.
For Dave Everton, an avid caver from Bloomington and one of the first to venture onto Big Bone Mountain, knowing that scientists think the cave is nationally significant is amazing. "We've found bones in caves, but nothing like this. ... We were in the right place at the right time.
"A lot of us are really excited about this."
Information from: The Courier-Journal, http://www.courier-journal.com
This is an AP Member Exchange shared by the Courier-Journal.


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One Bonnaroo music festival-goer received the surprise of a lifetime when her boyfriend popped the question among friends and strangers at the yearly event in Manchester, Tennessee last weekend.
John Ferreira wanted to propose to his girlfriend Catherine Mauro in a creative way and after the couple shared an amazing experience at the festival last year, he knew Bonnaroo was the right place to do it. He told HuffPost Weddings [1], "It's one of the few places on earth where you can just remain in the moment instead of worrying about work or bills. There is just an overall sense of freedom there, it's just magical."
After six months of planning, some help from friends he met on Reddit [2], and dozens of multi-color flowers, Ferreira orchestrated this adorable proposal. Check out the video below!
Ferreira handed out notecards with a flower to people at the festival filling them in on his plan and asking them to hand the flowers to girlfriend.
One-by-one people began walking up to Mauro and handing her the pretty blooms. She was so confused and distracted by the flowers that she didn't even notice Ferreira was down on one knee behind her.
She finally turned around and realized what was going on. The crowd began to cheer and with tears in her eyes she excitedly said 'yes!'
By the end of the proposal, they were both crying as they hugged each other. We love the enthusiasm of the man in the background!
The flower parade continued as friends came forward to congratulate the happy couple.
Best wishes to the future Mr. and Mrs. Ferreira!
— Mary Gillen
[1] http://www.huffingtonpost.com/2014/06/18/bonnaroo-marriage-proposa_n_5508199.html
[2] http://www.reddit.com/r/pics/comments/28ggzs/about_6_months_ago_i_decided_that_i_wanted_to/


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Perforce Software Offers On Demand Version
Perforce Software and Assembla announce the availability of an on demand version of Perforce Software Version Management that is integrated with team tools from Assembla.
Perforce on Demand, which combines enterprise-grade versioning with collaboration tools from Assembla, allows development teams to work together more effectively and accelerate Agile projects. The software, which is hosted by Assembla, is free for up to 20 users on Assembla's website.
According to the announcement, Perforce on Demand allows users to get a new depot in seconds, with triple-redundant backup. They can immediately invite other colleagues by email and don't need to wait for an administrator to authorize or configure repositories or users.
The software provides an activity stream that shows code commits and user activities. Code review and social coding features help distributed teams test, review, and merge code into frequent releases. Activity streams, code reviews, and merge requests can help Agile teams release improvements continuously.
Issue 168/2014
Tag Cloud
Mozilla Labs Shuts Down
Mozilla's product think tank sinks silently into history.
Internet Giants Launch Collaboration to Improve Open Source
TODO group will focus on open source tools in large-scale environments.
Fedora Announces New Partition Manager App
New tool will look like GParted but support a wider range of storage technologies.
Mozilla Releases a New Firefox
New public key pinning feature will help prevent man-in-the-middle attacks.
Tool Predicts Which Websites Will be Compromised
Carnegie Mellon researchers say 3 million pages could fall down the phishing hole in the next year.
SSH Key Management Guidelines
The US government rolls new best-practice rules for protecting SSH.
Knoppix 7.4 Released
Klaus Knopper announces the latest version of his iconic Live Linux system.
PHP Attack Puts WordPress and Drupal at Risk
All websites that use these popular CMS tools could be vulnerable to denial of service attacks if users don't install the updates.
Heartbleed Bleeds On
According to a report, many potential victims of the Heartbleed attack have patched their systems, but few have cleaned up the crime scene to protect themselves from the effects of a previous intrusion.
Drone Brain Goes Open Source
DARPA and NICTA release the code for the ultra-secure microkernel system used in aerial drones.


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Navy essential jogging bottoms
Item No.2850107236
These navy jogging bottoms from Adidas have an elasticated drawstring waist, two front pockets and an embroidered white logo on the left leg.
- Main material: 80% cotton, 20% polyester
- Elasticated drawstring waist
- Two front pockets
- Machine washable
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Debenhams is happy to exchange or refund your purchase within 28 days providing the goods are in a fully resaleable condition (including tags) and not within the exclusion policy*. This policy does not affect your statutory rights. You can return unwanted items either by visiting your local store (the fastest way to get a refund), by arranging a courier collection or returning by post. Exclusions apply to selected products. For instructions on how to return products and information on Debenhams refund policy visit the returns and refunds section of the website.


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Tested by the Good Housekeeping Research Institute
iRobot Roomba 560 Vacuum
Product Review
For time-strapped moms, iRobot's Roomba 560 is a technological masterpiece. Equipped with infrared sensors, the vac will canvass floors, get into corners, and even clean under beds — all while you're running errands or relaxing. You can set a timer so the Roomba automatically starts working on, say, Mondays and Thursdays at 11:15 a.m. It can move between rooms without your help, and even does its own quality control (if you place the Virtual Wall Lighthouse unit in a doorway, the device will not let the robot cross into the next space until it has vacuumed the area it started in). While the Roomba doesn't deep clean, it picked up virtually every speck we dropped on floors; all it asks is that you empty its dust tray after two or three outings. iRobot Roomba 560; 800-727-9077, irobot.com.
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Half of Miami City Ballet's annual support comes from the generosity of individual donors like you. Every contribution sustains our daily and long-term efforts to bring world-class dance to South Florida.JOIN US! There are several ways to become a member of the MCB family:
A nationally-acclaimed dance company like Miami City Ballet requires not only countless rehearsals and long hours building sets and costumes, but most importantly, the wholehearted support of the community. Your participation ensures our ability to plan and stage the performances you enjoy. As one of our supporters, you will have access to exclusive benefits and special offers at various levels of giving throughout the season.
For additional details, please contact the Development Department at (305) 929-7000 x1404 or email@example.com.
Donations can be made online by clicking on the link above, by e-mailing our Development Department at email@example.com, or by phone at 305.929.7000 x1404. You may also contribute by mail. Checks should be made payable to Miami City Ballet, and mailed to: Miami City Ballet ATTN: Development Department2200 Liberty AvenueMiami Beach, FL 33139 Miami City Ballet is profoundly grateful for your support.


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Henry Wiedrich
Henry Wiedrich
Management, Marketing and Business Law, School of Business
UB Beacom Hall 222
Phone: 605-677-5556
Email: firstname.lastname@example.com
Masters Degree in Education with 25 plus years in business and business management. Developed training programs for a variety of disciplines ranging from Mangement training to training for engineers. Currently teaching BADM 101 and BADM 460.
Teaching Interests:
BADM 101, Human Resources, and Training and Development
Research Interests:
Training and Development and Management
- MS, Secondary Education, Northern State University, 1979
- BS, Secondary Education, Norther State University, 1973


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In Stock
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The Analog Venerator Fitted S/S T-Shirt is one of the most unique and different logos out there. Only a certain audience can take it and make it their own. The stats are like this; Machine washable, crew neck, short sleeve. Analog doesn't mess around with quality or durability, the fabric is proven and the T is one of kind!
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Women's Tennis
PRIOR TO MSU: Served as team captain during junior and senior seasons ... Won District 17-4A individual titles in 2006 and 2007 as well as the team title in 2007 ... Placed first in 2007 Regional 3-4A and competed in State Championships ... Awarded academic honors including National Merit Scholar, National AP Scholar, MSU ADS Scholar and National Honor Society member.
PERSONAL: Full name is Kathryn Leatrice Bonnen ... Born Aug. 21, 1989, to Clarence and Susan Bonnen in Austin, Texas.
at the official


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#4 Wine Spectator Top 100 of 2009
Aromatics: Dominant notes of ripe raspberries and dark cherries. Slight traces of wet stone interplay with the fruit and encourage you to taste.
On the palate: Overlapping flavors of boysenberry, dark cherry, traces of nutmeg, savory baking spices and mouthwatering acidity mingle in perfect balance. The distinct fruit grabs your attention with its mid-palate saturation which is the precursor to a long, delectable finish. This is the perfect combination of intensity and elegance.
"Firm and focused, with a wonderful purity of flavor, offering a complex, focused mix of black cherry, raspberry, spice and anise. Full-bodied and concentrated. Long and persistent on the finish. Drink now through 2014. 3,069 cases made"
95 Points
Wine Spectator
"Bright red. Potent aromas of cherry and dark berry skin, smoky herbs, potpourri and black cardamom. Surprisingly fresh on the palate, with brighter red fruit and candied floral character supported by velvety tannins. The mineral note repeats on the long, seductively juicy finish."
91 Points
International Wine Cellar
"Ripe and rich, very nicely concentrated, focused on black cherry fruit with touches of dried violets, cinnamon-like spice and quiet hints of dark chocolate, this very delicious wine feels just a bit on the blocky, slightly tough side at present but has the depth and beauty to insure that it gets better and better over time. For near-term use, we would opt to partner it with sturdy or savory meats rather than more delicate choices."
91 Points
Connoisseurs' Guide
For almost 15 years, Kosta Browne has crafted intensely-flavored and balanced wines from the finest regions in California, including the Russian River Valley, Sonoma Coast and Santa Lucia Highlands appellations. Founders Dan Kosta, Michael Browne and Chris Costello's dedication to quality, stewardship and commitment to customer relationships has propelled the brand to industry leader, producing some of the most sought-after new world Pinot Noirs.
Twice as large as Napa in size, Sonoma County only makes about a half the amount of wine as her northeasterly neighbor. But Sonoma, with her size, is able to vouch for more diversity within her borders, including sub-AVAs that are climatically varied. The atmosphere of Sonoma is decidedly laid back and down home country style. But in wines, they are keeping up with the...Read More About Sonoma County
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text: Dear fans, our shop is currently closed and it will reopen at the end of this week...if you didn't get a chance to pick up this month's mystery bag, no worries… we'll have a few more available when we reopen! This month's Limited Edition set and Mystery Bag, plus The Yokai and a few other new surprises are making their way to our shop this week. It will all be unveiled to you this Friday, October 3rd at 10 PM EST (no tricks. just treats!) Love, RH


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The goal that wasn't for US Soccer
The game was tied 2-to-2, in the 85th minute. The United States was caught in a surge of momentum and Slovenia is being swallowed up by it. Landon Donovan had a free kick, and Maurice Edu blasts it into the net.
The U.S. had won. The Americans celebrate on the soccer pitch. A historic comeback is complete and the Yanks are moving on to the second round.
Or not.
Referee Koman Coulibaly's whistle blew. And the call was .wait, what was the call exactly?
"There was nothing. Absolutely nothing," former U.S. national team player Alexi Lalas said. "It was a bad call."
Was it an offside? Was it an inadvertent tackle? There was no apparent American penalty and there was no explanation by Coulibaly for what the call was, and by FIFA rules he does not have to give an explanation. He certainly didnt offer the Yanks any.
"I saw a good finish and a good goal," Donovan said afterward. "I don't know how much English he knows, but he didnt tell us anything. They didn't tell us what the call was."
As one of the announcers said during the games broadcast, Coulibaly had a rough game. Maybe it was the pressure of officiating his first World Cup match, but he had several missed and delayed calls. In the first half, he yellow-carded American forward, Robbie Findley, for a hand ball; when the ball hit Findley in the face.
But even with poor calls, the U.S. did themselves no favors in the first half.
With a mixture of timid play and weak defense, Slovenia took a two goal lead. With goal scoring at a premium in this World Cup, this was a near devastating deficit. Slovenia had obliterated the Yank defense. Valter Birsa sent a blast that froze up keeper Tim Howard in the 13th minute. Then in the 42nd minute Zlatan Ljubijankic sprinted past Oguchi Onyewu, leaving Howard in a loose-loose situation, alone, against an attacker.
Once again the U.S. had found themselves behind. It seems that in every game the Yanks have a hole that they have to attempt to dig themselves out of. And Donovan was up to the challenge. He was the best player on the field for the U.S. in the first half and in the third minute of the second he took the match on his shoulders and placed a shot over the head of Slovenian keeper Samir Handanovic.
Then in the 82nd minute, he lobbed a kick to Jozy Altidore, who headed the ball to a streaking Michael Bradley. Bradley blasted the ball into the net. Tie game.
Three minutes later it all went down.
"I made my run, pretty much uncontested, so I thought there would have been nothing to call it back. Then the ball came across, it went in and I thought it was a goal," Maurice Edu said on the goal that wasnt. "Obviously the ref saw something different."
Fortunately for the United States all hope is not lost. They control their own destiny. With a win, against Algeria next week, the Americans will be in the second round. And, thanks to England underperforming in a nil-nil tie against Algeria today, the only way the Brits can knock off the U.S. is if the Yanks loose. Or if the U.S. ties and England wins. All the U.S. has to do is win. All they have to do is knock off the weakest team in Group C.
And all this would be unnecessary if Edus goal had counted. The U.S. faces a must win because of the Goal that wasn't.Copyright © 2014, Chicago Tribune


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By Tanya EisererThe Dallas Morning News
DALLAS — The Dallas Police Department recently made changes to its hiring rules to relax standards related to drug use.
Full story:
Dallas PD eases hiring rules on drug use


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Your feet will be stingin'!
For a mere $14,800, the folks at Rayfish Footwear will breed a pair of genetically modified stingrays to your exact color and pattern specifications and then, when they're all grown up, turn them into a snazzy pair of shoes or sneakers. Guaranteed attention getters (because you'll be the guy with dozens of cats following him around).
Official Website:


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Duration: 7 minutes
An exciting story read by a special guest. Kimberley Walsh reads My Mum Has X-Ray Vision, by Angela McAllister and Alex T Smith.
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Vitamin E, Selenium Supplements Unlikely to Affect Age-Related Cataracts in MenSep. 18, 2014 Taking daily supplements of selenium or vitamin E appears to have no significant effect on the development of age-related cataracts in men. Some research, including animal studies, has suggested that ... full story
Second Look at Glaucoma Surgery: Anti-Inflammatory Medications After Glaucoma Laser Surgery Not Helpful or NecessarySep. 18, 2014 Using anti-inflammatory medications after glaucoma laser surgery is not helpful or necessary, new research concludes. Glaucoma is the most common cause of irreversible blindness in the world, and is ... full story
Americans Rate Losing Eyesight as Having Greatest Impact on Their LivesSep. 18, 2014 Many Americans across racial and ethnic groups describe losing eyesight as potentially having the greatest impact on their day-to-day life, more so than other conditions including: loss of limb, ... full story
Nine Fats to Include in a Healthy DietSep. 17, 2014 Fats are often considered the enemy of good nutrition, but when included in a healthy diet they can boast several potential health benefits. Fatty acids and nutritional oils may benefit cognition, ... full story
New Therapeutic Target May Prevent Blindness in Premature Babies at Risk of RetinopathySep. 16, 2014 New research opens the possibility of developing new, more selective drugs to control the abnormal growth of blood vessels and prevent blindness including retinopathy of prematurity, a disorder that ... full story
Cheaper Alternative to Licensed Drug for Treating Eye Disease Has Similar Side-EffectsSep. 15, 2014 Health policies that favour using ranibizumab for treating eye disease in older people over safety concerns for a cheaper alternative should take account of new research. Investigators reviewed the ... full story
Glaucoma: New Culprit Found by ResearchersSep. 12, 2014 Endothelial cells in Schlemm's canal -- important for draining fluid from the eye -- are stiffer in eyes with glaucoma than those in healthy eyes, a multi-institution team of researchers has ... full story
Yogic Breathing Shows Promise in Reducing Symptoms of PTSDSep. 11, 2014 New research offers hope for those suffering from post-traumatic stress disorder. Researchers there have shown that a breathing-based meditation practice called Sudarshan Kriya Yoga can be an ... full story
Not Enough Vitamin B1 Can Cause Brain DamageSep. 11, 2014 A deficiency of a single vitamin, B1 (thiamine), can cause a potentially fatal brain disorder called Wernicke encephalopathy. Symptoms can include confusion, hallucinations, loss of muscle ... full story
Missing Piece Found to Help Solve Concussion PuzzleSep. 10, 2014 A new, 5- to 10-minute test that could be added to a clinician's concussion evaluation toolkit for a more comprehensive assessment of the injury has been developed by scientists. "For the ... full story
New Glaucoma Cause Discovered, Leading to Eye Drops to Treat Molecular Basis of BlindnessSep. 9, 2014 Scientists have discovered a novel cause of glaucoma in an animal model, and related to their findings, are now developing an eye drop aimed at curing the disease. They believe their findings will be ... full story
Statins May Protect Against Microvascular Complications of DiabetesSep. 9, 2014 The development of common diabetes complications that can lead to blindness and amputations could be reduced by taking statins, indicates new research. Results showed that people who used statins ... full story
Education Vital to the Visually ImpairedSep. 9, 2014 Education is important for getting the visually impaired into work, a survey has found. This challenges the current situation in Norway in which partially sighted students are now exempt from several ... full story
Outdoor Activities May Be Linked to Exfoliation Syndrome in EyesSep. 4, 2014 Outdoor activities may increase the odds of developing exfoliation syndrome (XFS) in the eyes, a condition which has been linked to cataracts and glaucoma. XFS is a harmful aging of the eye ... full story
Researchers Define Spontaneous Retinal Neovascular Mouse ModelSep. 4, 2014 Researchers have characterized a novel mutant mouse model, termed neoretinal vascularization 2, which develops abnormal neovessels from retinal vascular plexus. Their hope is this new model will help ... full story
Mouse Studies Advance Treatment for Common Eye DiseasesSep. 3, 2014 Working with mice, a multicenter team of researchers has found a new way to reduce the abnormal blood vessel growth and leakage in the eye that accompany some eye diseases. The finding could lead to ... full story
Around 1 in 10 UK Women Has Dry Eye Disease, Requiring Artificial TearsSep. 3, 2014 Around one in 10 women in the UK has dry eye disease, requiring artificial tears or gel to lubricate the eyes and protect them from damage, reveals the first UK research of its kind. Altered pain ... full story
Molecular Probes Permit Doctors to Detect Diabetic Retinopathy Before Vision FailsSep. 2, 2014 A novel strategy to diagnose the leading cause of blindness in adults, diabetic retinopathy, before irreversible structural damage has occurred has now been described by researchers. "This study ... full story
Simple Test Could Detect Most Common Cause of Visual Impairment in the UKAug. 28, 2014 A simple color test that could detect the early onset of a condition which accounts for over half of visual impairment certifications in the UK is being researched by scientists. If left untreated, ... full story
Health Care Workers in Poor Nations Lack Gear Needed to Protect from Hiv and Other Bloodborne Infections Like EbolaAug. 26, 2014 Health care workers in some of the world's poorest countries lack basic equipment to shield them from HIV and other bloodborne infections during surgical and other procedures, new research ... full story
- Vitamin E, selenium supplements unlikely to affect age-related cataracts in men
- Second look at glaucoma surgery: Anti-inflammatory medications after glaucoma laser surgery not helpful or necessary
- Americans rate losing eyesight as having greatest impact on their lives
- Yogic breathing shows promise in reducing symptoms of PTSD
- Not enough vitamin B1 can cause brain damage
- New glaucoma cause discovered, leading to eye drops to treat molecular basis of blindness
- Statins may protect against microvascular complications of diabetes
- Education vital to the visually impaired
- Outdoor activities may be linked to exfoliation syndrome in eyes
- Researchers define spontaneous retinal neovascular mouse model
- Mouse studies advance treatment for common eye diseases
- Around 1 in 10 UK women has dry eye disease, requiring artificial tears
- Health care workers in poor nations lack gear needed to protect from hiv and other bloodborne infections like ebola
- Eye implant could lead to better glaucoma treatments
- Vision loss adversely affects daily function in older adults
- New DNA test for diagnosing diseases linked to childhood blindness
- Native American ancestry a risk factor for eye disease
- Proteins critical to wound healing identified
- Engineering long-lasting joint lubrication by mimicking nature
- Involuntary eye movement a foolproof indication for ADHD diagnosis
- Rural hospitals: Lean six sigma principles shorten queues, save time
- Neck manipulation may be associated with stroke
- New treatment successful for rare, disabling movement disorder, the Mal de Debarquement Syndrome (MdDS)
- Problem drinking in midlife doubles chance of memory problems in later life
- Vision-correcting display makes reading glasses so yesterday
- Parents need to talk to their children about school bus safety at the start of the school year
- Wearable device for early detection of common diabetes-related neurological condition
- Distinctive developmental origin for a drainage tube in the eye
- High-precision software developed for diagnosing eye sensitivity
- Iodine may alleviate swelling in retinitis pigmentosa patients' retinas
- Age-related macular degeneration occurs much earlier than previously assumed
- Acute glaucoma discovered to be an inflammatory disease
- New technology for diagnosis of cancer cells
- Novel treatment discovered for a form of childhood blindness
- Smell and eye tests show potential to detect Alzheimer's early
- Study of noninvasive retinal imaging device presented at Alzheimer's conference
- New compound treats both blindness, diabetes in animal studies
- Neurologist offers hope to patients with genetic tumor disorder
- Patient-specific stem cells and personalized gene therapy
- Alternative to surgery for Graves' eye disease: Low-carb, gluten-free diet may help
- Most prescription labels fail to meet guidelines, risking dosage errors, Canadian study concludes
- Rehabilitation helps prevent depression from age-related vision loss
- Blind lead the way in brave new world of tactile technology
- Gene critical to early development of cilia identified
- Shock wave from explosives causes significant eye damage
- Soothing cells, peaceful protein could hold promise for treating autoimmune uveitis
- Breathe easy and don't scratch this Fourth of July
- Doctors urge caution with Fourth of July fireworks
- Trained evaluators can screen for premie eye disease from miles away
- Increased nearsightedness linked to higher education levels and more years spent in school
- Challenges of visual accessibility for people with low vision
- Exploring the brain: New findings explain how eyes link to prefrontal cortex
- Howzat eyesight? New study analyses how cricketers' visual skills change with age
- Drug shows promise for the first time against metastatic melanoma of the eye
- Neurons get their neighbors to take out their trash
- Exploring how the nervous system develops
- Who's your daddy? Team programs computer to find out
- Fireworks lead to millions in health costs for amputations
- Hyperthyroidism patients more likely to take extended sick leave than healthy peers
- Soccer-related facial fractures examined
- Eye's optical quality deteriorates after alcohol consumption
- Getting rid of old mitochondria: Some neurons turn to neighbors to help take out the trash
- Omega-3 inhibits blood vessel growth in age-related macular degeneration
- Sensor in eye could track pressure changes, monitor for glaucoma
- Is glaucoma a brain disease? Scientists find that jigsaw effect in glaucoma patients proves it is
- Diabetes care depends on how your doctor is paid
- Making artificial vision look more natural
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It's been proven many times that smoking is horrible for our health.
On top of that, secondhand smoke isn't good for us either.
But what about "thirdhand smoke?"
Dr. Mike was live on "Good Day Philadelphia" Friday with the new warning and possible DNA damage worry.
Join FOX 29's Mike Jerrick and the Good Day Philadelphia team for a tasty night of yummy treats benefiting local youth.
35 Skyline DriveLake Mary, FL 32746
Phone: (407) 644-3535News Tips: (866) 55-FOX35


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Issues: Poverty
Approximately 1.3 billion people in developing countries live on $1.25 a day or less. Between 1990 and 2008, efforts to reduce this number were highly successful and the amount of people living in poverty decreased by nearly half, from 48 to 26 percent. But according to the latest United Nations reports food prices are back on the rise, causing an increase in global poverty for the first time in nearly two decades.
Poverty, food prices and hunger are inextricably linked. Poverty causes hunger. Not every poor person is hungry, but almost all hungry people are poor. Millions live with hunger and malnourishment because they simply cannot afford to buy enough food, cannot afford nutritious foods or cannot afford the farming supplies they need to grow enough good food of their own [1]. Hunger can be viewed as a dimension of extreme poverty. It is often called the most severe and critical manifestation of poverty.
Rural households are the most heavily burdened by the consequences of poverty and hunger. In addition to causing hunger, poverty limits a rural community's ability to invest in its own development. Over 30 percent of rural girls living in poverty are kept out of school to save money, opposed to the 15 percent of urban girls not in school. Studies have shown that lack of general education leads to higher adolescent birth rates; births that in turn over-burden an already economically strained community, perpetuating a cycle of gender inequality, poverty and hunger.
Recognizing the urgency of this issue, world leaders have made poverty a top priority as a part of Millennium Development Goal 1.
The Hunger Project (THP) takes a holistic approach to hunger, which means addressing its root causes – including poverty. In THP Program Countries, we build the capacity of women and men to move beyond poverty, training them in the skills, methods, knowledge and leadership needed to take self-reliant actions so they can meet their own basic needs, improve their communities and build better futures for themselves and their children.
What We Do
- At our epicenters across Africa, thousands of women food farmers are increasing their incomes through training and credit, and strengthening their clout in the marketplace. Over 45,000 women and men participate in our Microfinance Program, and in 2011, they deposited more than $1.6 million in savings in epicenter Rural Banks and revolving loan funds.
- The ultimate objective of THP's Microfinance Program is to gain government recognition and operate as a licensed saving and credit cooperative (SACCO) or Rural Bank. Owned entirely by community members, the Rural Bank then provides the entire epicenter community with sustainable access to savings and loan facilities. There are now 22 Rural Banks that have gained government recognition at our epicenters in Africa.
- Trained THP partners implement income-generating activities, often joining together in self-help groups: from sewing projects in Mexico to cow-fattening projects in Bangladesh. In 2010, 12,341 of our African partners participated in income-generating workshops to learn new and innovative methods of increasing household income.
- In Africa, THP empowers people to create, stock and manage their own food banks at the community level, which helps stabilize day-to-day food prices in local markets during times of crisis. In 2010 alone, community members stocked 482,040 kgs of grains in their food banks across Africa.
- Through agricultural trainings and increased access to farming inputs, small farmers in THP communities are able to increase their crop yields, enabling them to grow enough food to feed their families, diversify their crops and even sell surpluses at market.
- In Burkina Faso and Senegal, a warrantage program allows farmers to not only contribute their share, but also to store their excess harvest in the epicenter food bank until market conditions shift. As a result, farmers can sell their produce for higher prices.
Featured Articles
- MDG 1: Eradicate Extreme Hunger and Poverty
- Microfinance Program in Africa
- Case Study: Putting Vision Into Action (income generation in Bangladesh)
- Case Study: Training and Microfinance Fund a Farm and Build a Dream Home, THP-Ethiopia
- Case Study: Small Farming in Ghana with THP
- Case Study: Leader in Ghana Increases her Income by 600 percent
- Gudatu Rural Bank Inauguration in Ethiopia
- Hunger and Poverty: a report that aims to clarify these and related terms
Give Now
Join THP in ensuring safe drinking water and adequate sanitation by investing now. You will be saving children's lives, enabling girls to return to school, and empowering people to lead healthy and productive lives.
More Resources
- Know Your World: Facts about Hunger and Poverty
- Issues: Environment
- Issues: HIV/AIDS and Other Diseases
- Issues: Water and Sanitation
- Issues: Gender Discrimination
- Issues: World Hunger
1. Pinstrup-Anderson, Per. "Still Hungry." Scientific American Special Issue. Sept 2007.
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Published January 2014. Revised January 2014.
Presents research-based principles of adolescent substance use disorder treatment; covers treatment for a variety of drugs including, illicit and prescription drugs, alcohol, and tobacco; presents settings and evidence-based approaches unique to treating adolescents.
Published December 2012. Revised January 2014.
Describes trends in high school and youth drug abuse and addiction, with an emphasis on marijuana, cigarettes, prescription drugs, alcohol and ecstasy.
En Español
Published April 2011. Revised January 2014.
Examines nationwide trends in drug abuse and addiction among youth, describing lifetime, past year and past month use for alcohol, tobacco, illicit drugs, and prescription drugs.
En Español
Published November 2013. Revised September 2014.
Electronic cigarettes (also called e-‐cigarettes or electronic nicotine delivery systems) are smokeless, battery operated devices designed to deliver nicotine with flavorings or other chemicals to the lungs of users without burning tobacco
En Español
Call 1-877-643-2644 or:


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Career in Sweden - find jobs here
In collaboration with the three leading employment companies — StepStone, CareerBuilder and Monster — we offer the largest and most comprehensive Jobs section for English speakers in Sweden.
At The Swedish Wire's Jobs section you'll find hundreds of great job opportunities for foreign professionals at Sweden's top employers.
Find all jobs at swedishwire.com/jobs. All the best of luck!
Last Updated (Monday, 29 October 2012 04:51)