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Chapter 16. Psychopathology: Biological Basis of Behavior Disorders
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By Sandra G. Boodman, As the jet hurtled toward New York's John F. Kennedy International Airport on New Year's Day 2013, the clinical psychologist watched her 16-year-old daughter warily, praying there would be no recurrence of the girl's inexplicable and bizarre behavior. The previous night, while walking down a street in Spain where the family had spent Christmas, the teenager suddenly began yelling that the traditional New Year's Eve fireworks were actually bombs. On the flight home, the girl seemed entirely normal. Her mother thought the high school junior might have had a panic attack, stressed by her upcoming college search and impending wisdom teeth extraction. But the uneventful flight brought a short-lived relief. Five days later, the teenager was hospitalized for treatment of what appeared to be a severe psychotic break. And for the next six weeks, the news seemed to get worse as a more ominous diagnosis emerged — and with it the specter of death. "Every day seemed like a horror story," said Carmen, a psychoanalyst who practices in New York and whose last name, along with that of her daughter, Mia, is being withheld at her request to protect her professional privacy. For Lara Marcuse, a neurologist at Mount Sinai Hospital in Manhattan who treated Mia during her hospitalization, those weeks were filled with tension and anxiety that deepened as she worried that the teenager might not survive her sudden illness. "If she was my age," said Marcuse, who is 44, "Mia would either be dead, in a coma or in a state psychiatric center." Instead Mia, now 18, has fully recovered. She recently had a part in her high school play, is anticipating graduation and looking forward to entering college in September. © 1996-2014 The Washington Post
Keyword: Schizophrenia
Link ID: 19548 - Posted: 04.29.2014
By MATTHEW PERRONE WASHINGTON (AP) — The Food and Drug Administration announced Friday it will convene a public meeting in October to review the risks of psychiatric and behavioral side effects with Pfizer's anti-smoking drug Chantix. The agency said in a federal notice it will convene its panel of psychiatric drug experts to discuss the pill's risks and how to best manage them. Since 2009 Chantix has carried the government's strongest safety warning — a ''black box'' label — because of links to hostility, agitation, depression and suicidal thoughts. The warning was added after the FDA received dozens of reports of suicide and hundreds of reports of suicidal behavior among patients taking the smoking-cessation drug. At that time, the FDA also required Pfizer to conduct additional studies to determine the extent of the side effects. A spokeswoman for Pfizer said Friday that the company recently submitted new data to the FDA comparing the drug's psychiatric safety to placebo and other anti-smoking techniques. The FDA first began investigating potential side effects with Chantix in 2007, the year after the twice-a-day pill hit the market. The drug's labeling tells patients to stop taking Chantix immediately if they experience agitation, depressed mood, suicidal thinking and other behavioral changes. Doctors are advised to weigh the drug's risks against its potential benefits in helping patients quit smoking.
Keyword: Drug Abuse; Aggression
Link ID: 19535 - Posted: 04.26.2014
by Michael Slezak Could preventing the brain shrinkage associated with depression be as simple as blocking a protein? Post-mortem analysis of brain tissue has shown that the dendrites that relay messages between neurons are more shrivelled in people with severe depression than in people without the condition. This atrophy could be behind some of the symptoms of depression, such as the inability to feel pleasure. As a result, drugs that help repair the neuronal connections, like ketamine, are under investigation. But how this shrinkage occurs has remained a mystery, limiting researchers' ability to find ways of stopping it. Ronald Duman at Yale University wondered whether a protein called REDD1, which was recently shown to reduce myelin, the fatty material that protects neurons, was the key. To find out, his team bred rats unable to produce REDD1 and exposed them to a prolonged period of unpredictable stress. In normal rats, this stress resulted in depressive-like behaviour and brain shrinkage, but Duman's rats were unaffected. In contrast, rats engineered to overproduce REDD1 became depressed and had brain shrinkage, even without being stressed. What's more, injecting normal rats with a stress hormone boosted levels of REDD1 in the brain. Giving them a drug that blocked the production of stress hormones stopped them producing the protein, even when they were externally stressed. Taken together, the experiments show that REDD1 is necessary to produce the brain shrinkage seen in stressed rats, and that stress hormones are involved in its production – offering a possible way to prevent the shrinkage. © Copyright Reed Business Information Ltd
Keyword: Depression
Link ID: 19532 - Posted: 04.24.2014
By Melissa Healy The nature of psychological resilience has, in recent years, been a subject of enormous interest to researchers, who have wondered how some people endure and even thrive under a certain amount of stress, and others crumble and fall prey to depression. The resulting research has underscored the importance of feeling socially connected and the value of psychotherapy to identify and exercise patterns of thought that protect against hopelessness and defeat. But what does psychological resilience look like inside our brains, at the cellular level? Such knowledge might help bolster peoples' immunity to depression and even treat people under chronic stress. And a new study published Thursday in Science magazine has made some progress in the effort to see the brain struggling with -- and ultimately triumphing over -- stress. A group of neuroscientists at Mount Sinai's Icahn School of Medicine in New York focused on the dopaminergic cells in the brain's ventral tegmentum, a key node in the brain's reward circuitry and therefore an important place to look at how social triumph and defeat play out in the brain. In mice under stress because they were either chronically isolated or rebuffed or attacked by fellow littermates, the group had observed that this group of neurons become overactive. It would logically follow, then, that if you don't want stressed mice (or people) to become depressed, you would want to avoid hyperactivity in that key group of neurons, right? Actually, wrong, the researchers found. In a series of experiments, they saw that the mice who were least prone to behave in socially defeated ways when under stress were actually the ones whose dopaminergic cells in the ventral tegmental area displayed the greatest levels of hyperactivity in response to stress. And that hyperactivity was most pronounced in the neurons that extended from the tegmentum into the nearby nucleus accumbens, also a key node in the brain's reward system.
Keyword: Depression; Aggression
Link ID: 19511 - Posted: 04.21.2014
Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's a twist. Instead of suppressing it, researchers funded by the National Institutes of Health boosted runaway neuronal activity even further, eventually triggering a compensatory self-stabilizing response. Once electrical balance was restored, previously susceptible animals were no longer prone to becoming withdrawn, anxious, and listless following socially stressful experiences. "To our surprise, neurons in this circuit harbor their own self-tuning, homeostatic mechanism of natural resilience," explained Ming-Hu Han, Ph.D External Web Site Policy., of the Icahn School of Medicine at Mount Sinai, New York City, a grantee of the NIH's National Institute of Mental Health (NIMH) and leader of the research team. Han and colleagues report on their discovery April 18, 2014 in the journal Science. Prior to the new study, the researchers had turned resilience to social stress on and off by using pulses of light to manipulate reward circuit neuronal firing rates in genetically engineered mice – optogenetics. But they didn't know how resilience worked at the cellular level. To find out, they focused on electrical events in reward circuit neurons of mice exposed to a social stressor. Some mice that experience repeated encounters with a dominant animal emerge behaviorally unscathed, while others develop depression-like behaviors.
Keyword: Depression; Aggression
Link ID: 19510 - Posted: 04.19.2014
By DORIS IAROVICI, M.D. "I think our experiment failed," the young graduate student told me, referring to our attempt to take her off the antidepressant she'd been on for seven years. She was back in my campus office after a difficult summer break, and as she talked about feeling unsettled and upset, I wondered about the broader experiment playing out on college campuses across the country. Antidepressants are an excellent treatment for depression and anxiety. I've seen them improve — and sometimes save — many young lives. But a growing number of young adults are taking psychiatric medicines for longer and longer periods, at the very age when they are also consolidating their identities, making plans for the future and navigating adult relationships. Are we using good scientific evidence to make decisions about keeping these young people on antidepressants? Or are we inadvertently teaching future generations to view themselves as too fragile to cope with the adversity that life invariably brings? My patient had started medication as a college freshman, after she'd become depressed and spent much of her time in bed. She was forced to take a medical leave but improved quickly, returned to school and graduated. She married soon after and worked for a few years, feeling well all the while. Professional guidelines recommend six to nine months of medicine for first episodes of depression. But my patient had never been advised to stop taking it. She reluctantly agreed to my recommendation to taper off her antidepressant. © 2014 The New York Times Company
Keyword: Depression
Link ID: 19502 - Posted: 04.17.2014
On Wednesday morning we woke to the news that a passenger ferry had sunk off the coast of South Korea, with at least four people confirmed dead and 280 unaccounted for. Meanwhile, though the search has continued for the missing Malaysia Airlines plane, relatives' hopes of a safe landing have long since been extinguished. Human tragedies like these are the stuff of daily news, but we rarely hear about the long-term psychological effects on survivors and the bereaved, who may experience the symptoms of post-traumatic stress disorder for years after their experience. Although most people have heard of PTSD, few will have a clear idea of what it entails. The American Psychiatric Association's Diagnostic and Statistical Manual (DSM) defines a traumatic event as one in which a person "experienced, witnessed, or was confronted with an event or events that involved actual or threatened death or serious injury, or a threat to the physical integrity of self or others". PTSD is marked by four types of responses to the trauma. First, patients repeatedly relive the event, either in the form of nightmares or flashbacks. Second, they seek to avoid any reminder of the traumatic event. Third, they feel constantly on edge. Fourth, they are plagued with negative thoughts and low mood. According to one estimate, almost 8% of people will develop PTSD during their lifetime. Clearly trauma (and PTSD) can strike anyone, but the risks of developing the condition are not equally distributed. Rates are higher in socially disadvantaged areas, for instance. Women may be twice as likely to develop PTSD as men. This is partly because women are at greater risk of the kinds of trauma that commonly produce PTSD (rape, for example). Nevertheless – and for unknown reasons – when exposed to the same type of trauma, women are more susceptible to PTSD than men. © 2014 Guardian News and Media Limited
Keyword: Stress; Aggression
Link ID: 19501 - Posted: 04.17.2014
By BENEDICT CAREY The relationship had become intolerably abusive, and after a stinging phone call one night, it seemed there was only one way to end the pain. Enough wine and pills should do the job — and would have, except that paramedics barged through the door, alerted by her lover. "I very rarely tell the story in detail publicly, it's so triggering and sensational," said Dese'Rae L. Stage, 30, a photographer and writer living in Brooklyn who tried to kill herself in 2006. "I talk about what led up to it, how helpless I felt — and what came after." The nation's oldest suicide prevention organization, the American Association of Suicidology, decided in a vote by its board last week to recognize a vast but historically invisible portion of its membership: people, like Ms. Stage, who tried to kill themselves but survived. About a million American adults a year make a failed attempt at suicide, surveys suggest, far outnumbering the 38,000 who succeed, and in the past few years, scores of them have come together on social media and in other forums to demand a bigger voice in prevention efforts. Plans for speakers bureaus of survivors willing to tell their stories are well underway, as is research to measure the effect of such testimony on audiences. For decades, mental health organizations have featured speakers with schizophrenia, bipolar disorder and depression. But until now, suicide has been virtually taboo, because of not only shame and stigma, but also fears that talking about the act could give others ideas about how to do it. "This is a real shift you're seeing," said Heidi Bryan, 56, of Neenah, Wis., who has been speaking for years about suicide attempts she made in the 1990s. "For people working in suicide prevention, they always told us not to talk about our own experience, like they were afraid to tip us over the edge or something. Honestly, we're the ones who know what works and what doesn't." © 2014 The New York Times Company
Keyword: Depression
Link ID: 19481 - Posted: 04.14.2014
|By Scott O. Lilienfeld and Hal Arkowitz A rabble-rousing patient on a psychiatric ward is brought into a room and strapped to a gurney. He is being punished for his defiance of the head nurse's sadistic authority. As he lies fully awake, the psychiatrist and other staff members place electrodes on both sides of his head and pass a quick jolt of electricity between them. Several orderlies hold the patient down while he grimaces in pain, thrashes uncontrollably and lapses into a stupor. This scene from the 1975 Academy Award–winning film One Flew Over the Cuckoo's Nest, starring Jack Nicholson as the rebellious patient, has probably shaped the general public's perceptions of electroconvulsive therapy (ECT) far more than any scientific description. As a result, many laypeople regard ECT as a hazardous, even barbaric, procedure. Yet most data suggest that when properly administered, ECT is a relatively safe and often beneficial last-resort treatment for severe depression, among other forms of mental illness. One Flew Over the Cuckoo's Nest is far from the only negative portrayal of ECT in popular culture. In a 2001 survey of 24 films featuring the technique, psychiatrists Andrew McDonald of the University of Sydney and Garry Walter of Northern Sydney Central Coast Health of New South Wales reported that the depictions of ECT are usually pejorative and inaccurate. In most cases, ECT is delivered without patients' consent and often as retribution for disobedience. The treatment is typically applied to fully conscious and terrified patients. Following the shocks, patients generally lapse into incoherence or a zombielike state. In six films, patients become markedly worse or die. Probably as a result of such portrayals, the general public holds negative attitudes toward ECT. © 2014 Scientific American
Keyword: Depression
Link ID: 19475 - Posted: 04.12.2014
By NICHOLAS BAKALAR A new study adds to the evidence that the use of antidepressants during pregnancy is associated with a higher risk of premature birth, though many factors most likely play a role and the relationship is complex. Researchers reviewed data from 41 studies, some of which controlled for factors like smoking, alcohol or coffee drinking, weight gain during pregnancy, and other behavioral and health issues. They found no increase in the risk of early birth with the use of antidepressants during the first trimester, a 53 percent higher risk over all and a 96 percent higher risk with antidepressant use late in pregnancy. Depression itself is a risk factor for premature births, and a few studies tried to account for this by using, as a control, a group of women with a diagnosis of depression who did not take antidepressants during their pregnancy. Generally, researchers still found a higher, though diminished, risk from taking antidepressants. The review was published in March in PLOS One. Does this mean that all pregnant women should avoid these drugs? No, said the senior author, Dr. Adam C. Urato, an assistant professor of maternal-fetal medicine at Tufts University. Risks and benefits have to be balanced, he said. "It's very complex, and depends on the severity of the disease," Dr. Urato added. "The point is that we have to get the right information out so that we can let pregnant women make an informed decision." © 2014 The New York Times Company
Keyword: Depression; Aggression
Link ID: 19454 - Posted: 04.08.2014
By BARBARA EHRENREICH MY atheism is hard-core, rooted in family tradition rather than adolescent rebellion. According to family legend, one of my 19th-century ancestors, a dirt-poor Irish-American woman in Montana, expressed her disgust with the church by vehemently refusing last rites when she lay dying in childbirth. From then on, we were atheists and rationalists, a stance I perpetuated by opting, initially, for a career in science. How else to understand the world except as the interaction of tiny bits of matter and mathematically predictable forces? There were no gods or spirits, just our own minds pressing up against the unknown. But something happened when I was 17 that shook my safely rationalist worldview and left me with a lifelong puzzle. Years later, I learned that this sort of event is usually called a mystical experience, and I can see in retrospect that the circumstances had been propitious: Thanks to a severely underfunded and poorly planned skiing trip, I was sleep-deprived and probably hypoglycemic that morning in 1959 when I stepped out alone, walked into the streets of Lone Pine, Calif., and saw the world — the mountains, the sky, the low scattered buildings — suddenly flame into life. There were no visions, no prophetic voices or visits by totemic animals, just this blazing everywhere. Something poured into me and I poured out into it. This was not the passive beatific merger with "the All," as promised by the Eastern mystics. It was a furious encounter with a living substance that was coming at me through all things at once, too vast and violent to hold on to, too heartbreakingly beautiful to let go of. It seemed to me that whether you start as a twig or a gorgeous tapestry, you will be recruited into the flame and made indistinguishable from the rest of the blaze. I felt ecstatic and somehow completed, but also shattered. © 2014 The New York Times Company
Keyword: Schizophrenia; Aggression
Link ID: 19452 - Posted: 04.07.2014
By LISA SANDERS, M.D. On Thursday, we challenged Well readers to solve the mystery of a 23-year-old man with episodes of aggressive, manic behavior that couldn't be controlled. Nearly 1,000 readers wrote in with their take on this terrifying case. More than 300 of you got the right class of disease, and 21 of you nailed the precise form of the disorder. Amazing! The correct diagnosis is … Variegate porphyria The first person with the correct answer was Francis Graziano, a 23-year-old recent graduate of the University of Michigan. His major in neuroscience really gave him a leg up on this case, he told me. He recalled a case he read of a young Vietnam veteran with symptoms of porphyria. He's a surgical technician right now, waiting to hear where he'll be going to medical school next year. Strong work, Dr.-to-be Graziano! The Diagnosis: The word porphyria comes from the ancient Greek word for purple, "porphyra," because patients with this disease can have purplish-red urine, tears or saliva. The porphyrias are a group of rare genetic diseases that develop in patients born without the machinery to make certain essential body chemicals, including one of the most important parts of blood known as heme. This compound makes up the core of the blood component hemoglobin. (The presence of heme is why blood is red.) Patients who can't make heme correctly end up with too much of its chemical precursors, known as porphyrins. The excess porphyrins injure tissues throughout the body, but especially in the nervous system. The disorder is characterized by frequent episodes of debilitating back or abdominal pain and is often accompanied by severe psychiatric symptoms. Patients with porphyria do not respond to most psychiatric medications. Indeed, many of these drugs make the symptoms of porphyria worse. © 2014 The New York Times Company
Keyword: Schizophrenia
Link ID: 19448 - Posted: 04.05.2014
David Adam The day the Brazilian racing driver Ayrton Senna died in a crash, I was stuck in the toilet of a Manchester swimming pool. The door was open, but my thoughts blocked the way out. It was May 1994. I was 22 and hungry. After swimming a few lengths of the pool, I had lifted myself from the water and headed for the locker rooms. Going down the steps, I had scraped the back of my heel on the sharp edge of the final step. It left a small graze through which blood bulged into a blob that hung from my broken skin. I transferred the drop to my finger and a second swelled to take its place. I pulled a paper towel from above the sink to press to my wet heel. The blood on my finger ran with the water as it dripped down my arm. My eyes followed the blood. And the anxiety, of course, rushed back, ahead even of the memory. My shoulders sagged. My stomach tightened. Four weeks earlier, I had pricked my finger on a screw that stuck out from a bus shelter's corrugated metal. It was a busy Saturday afternoon and there had been lots of people around. Any one of them, I thought, could easily have injured themselves in the way I had. What if one had been HIV positive? They could have left infected blood on the screw, which then pierced my skin. That would put the virus into my bloodstream. I knew the official line was that transmission was impossible this way – the virus couldn't survive outside the body – but I also knew that, when pressed for long enough, those in the know would weaken the odds to virtually impossible. They couldn't be absolutely sure. In fact, several had admitted to me there was a theoretical risk. © 2014 Guardian News and Media Limited
Keyword: OCD - Obsessive Compulsive Disorder
Link ID: 19447 - Posted: 04.05.2014
By James Gallagher Health and science reporter, BBC News The illegal party drug ketamine is an "exciting" and "dramatic" new treatment for depression, say doctors who have conducted the first trial in the UK. Some patients who have faced incurable depression for decades have had symptoms disappear within hours of taking low doses of the drug. The small trial on 28 people, reported in the Journal of Psychopharmacology, shows the benefits can last months. Experts said the findings opened up a whole new avenue of research. Depression is common and affects one-in-10 people at some point in their lives. Antidepressants, such as prozac, and behavioural therapies help some patients, but a significant proportion remain resistant to any form of treatment. A team at Oxford Health NHS Foundation Trust gave patients doses of ketamine over 40 minutes on up to six occasions. Eight showed improvements in reported levels of depression, with four of them improving so much they were no longer classed as depressed. Some responded within six hours of the first infusion of ketamine. Lead researcher Dr Rupert McShane said: "It really is dramatic for some people, it's the sort of thing really that makes it worth doing psychiatry, it's a really wonderful thing to see. He added: "[The patients] say 'ah this is how I used to think' and the relatives say 'we've got x back'." Dr McShane said this included patients who had lived with depression for 20 years. Stressed man The testing of ketamine has indentified some serious side-effects The duration of the effect is still a problem. Some relapse within days, while others have found they benefit for around three months and have since had additional doses of ketamine. There are also some serious side-effects including one case of the supply of blood to the brain being interrupted. Doctors say people should not try to self-medicate because of the serious risk to health outside of a hospital setting. BBC © 2014
Keyword: Depression; Aggression
Link ID: 19444 - Posted: 04.03.2014
|By Hal Arkowitz and Scott O. Lilienfeld A commercial sponsored by Pfizer, the drug company that manufactures the antidepressant Zoloft, asserts, "While the cause [of depression] is unknown, depression may be related to an imbalance of natural chemicals between nerve cells in the brain. Prescription Zoloft works to correct this imbalance." Using advertisements such as this one, pharmaceutical companies have widely promoted the idea that depression results from a chemical imbalance in the brain. The general idea is that a deficiency of certain neurotransmitters (chemical messengers) at synapses, or tiny gaps, between neurons interferes with the transmission of nerve impulses, causing or contributing to depression. One of these neurotransmitters, serotonin, has attracted the most attention, but many others, including norepinephrine and dopamine, have also been granted supporting roles in the story. Much of the general public seems to have accepted the chemical imbalance hypothesis uncritically. For example, in a 2007 survey of 262 undergraduates, psychologist Christopher M. France of Cleveland State University and his colleagues found that 84.7 percent of participants found it "likely" that chemical imbalances cause depression. In reality, however, depression cannot be boiled down to an excess or deficit of any particular chemical or even a suite of chemicals. "Chemical imbalance is sort of last-century thinking. It's much more complicated than that," neuroscientist Joseph Coyle of Harvard Medical School was quoted as saying in a blog by National Public Radio's Alix Spiegel. © 2014 Scientific American
Keyword: Depression
Link ID: 19432 - Posted: 04.01.2014
By Lenny Bernstein After 60 years of refusing, the people who run the Golden Gate Bridge are moving toward installing a suicide barrier, the New York Times reports. As soon as May, the Golden Gate Bridge, Highway and Transportation District is expected to approve construction of a steel mesh net 20 feet below the California landmark's sidewalk. A record 46 people jumped to their deaths from the span in 2013, and another 118 were stopped before they could. According to the Times, they have tended to be younger than in the past. Experts have long known, and good research shows, that barriers are highly effective at halting suicides, the 10th-leading cause of death in the United States at 38,364 fatalities in 2010. This is true not just of bridges or other high places: locking up firearms and individually bubble-wrapping pills both limit suicides by those methods, said Jill Harkavy-Friedman, vice president of research for the American Foundation for Suicide Prevention. The key is the characteristics of a person on the verge of committing suicide, even someone who has been contemplating it for a while. Suicides are impulsive acts, and the people who commit them are not thinking clearly, have trouble solving problems, have difficulty shifting gears and weigh risks differently. If thwarted in that first, impulsive attempt, they often do not adjust and seek another way to take their lives, Harkavy-Friedman said. "In a suicidal crisis, it's all about time," she said. "They're going to grab whatever is available. They don't change gears if that is thwarted, because they have rigid thinking in that moment. They're not thinking about dying. They're thinking about ending the pain. © 1996-2014 The Washington Post
Keyword: Depression
Link ID: 19423 - Posted: 03.29.2014
By NICHOLAS BAKALAR A large study has linked several common anti-anxiety drugs and sleeping pills to an increased risk of death, although it's not certain the drugs were the cause. For more than seven years, researchers followed 34,727 people who filled prescriptions for anti-anxiety medications like Valium and Xanax, or sleep aids like Ambien, Sonata and Lunesta, comparing them with 69,418 controls who did not. After adjusting for a wide variety of factors, the researchers found that people who took the drugs had more than double the risk of death. The study appears online in BMJ. The researchers tried to account for the use of other prescribed drugs, age, smoking, alcohol use, socioeconomic status, and other health and behavioral characteristics. Most important, the investigators also controlled for sleep disorders, anxiety disorders and other psychiatric illnesses, all of which are risk factors for mortality. The lead author, Dr. Scott Weich, a professor of psychiatry at the University of Warwick, said that while he and his colleagues were careful to account for as many potential risks as possible, they were not able to control for the severity of the illnesses suffered by the study participants. Still, he said, the research "adds to an accumulating body of evidence that these drugs are dangerous." He added: "I prescribe these drugs, and they are difficult to come off. The less time you spend on them the better." © 2014 The New York Times Company
Keyword: Depression; Aggression
Link ID: 19419 - Posted: 03.29.2014
by Colin Barras What a nerve! Skin cells taken from people with bipolar disorder have been turned into brain cells. These in turn are offering up clues about the changes in the brain that drive the disorder, and may also provide a way to test new treatments. About three in every 100 people develop bipolar disorder – a mental illness characterised by episodes of depression and euphoria. But the condition remains poorly understood. That's because it would be too invasive to obtain and study viable nerve cells from the brains of people with the condition. There are also no good animal models, because bipolar disorder – although highly heritable – has, for the most part, not been linked to any specific genes that can be studied using animals. "People say the condition is probably the result of a lot of small contributions by multiple genes," says Sue O'Shea at the University of Michigan in Ann Arbor. Now O'Shea and her colleagues may have found an ethical way to make a genetic model of the condition. First, they took skin samples from 22 people with bipolar disorder and 10 healthy volunteers. They induced these adult skin cells to return to a stem-cell-like state, creating what are called induced pluripotent stem cells (iPSCs) and then encouraged these cells to mature into neurons. O'Shea was surprised to find that neurons derived from people with bipolar disorder grew differently from those from people without the condition. "I was expecting it would take decades of careful science before we would find any real differences," she says. © Copyright Reed Business Information Ltd.
Keyword: Schizophrenia; Aggression
Link ID: 19412 - Posted: 03.26.2014
By Gisela Telis, Jodi Corbitt had been battling depression for decades and by 2010 had resigned herself to taking antidepressant medication for the rest of her life. Then she decided to start a dietary experiment. To lose weight, the 47-year-old Catonsville, Md., mother stopped eating gluten, a protein found in wheat and related grains. Within a month she had shed several pounds — and her lifelong depression. "It was like a veil lifted and I could see life more clearly," she recalled. "It changed everything." Corbitt had stumbled into an area that scientists have recently begun to investigate: whether food can have as powerful an impact on the mind as it does on the body. Research exploring the link between diet and mental health "is a very new field; the first papers only came out a few years ago," said Michael Berk, a professor of psychiatry at the Deakin University School of Medicine in Australia. "But the results are unusually consistent, and they show a link between diet quality and mental health." "Diet quality" refers to the kinds of foods that people eat, how often they eat them and how much of them they eat. In several studies, including a 2011 analysis of more than 5,000 Norwegians, Berk and his collaborators have found lower rates of depression, anxiety and bipolar disorder among those who consumed a traditional diet of meat and vegetables than among people who followed a modern Western diet heavy with processed and fast foods or even a health-food diet of tofu and salads. © 1996-2014 The Washington Post
Keyword: Depression
Link ID: 19403 - Posted: 03.25.2014
By Ariana Eunjung Cha, Millions of ordinary Americans are now able to walk into a marijuana dispensary and purchase bags of pot on the spot for a variety of medical ailments. But if you're a researcher like Sue Sisley, a psychiatrist who studies post- traumatic stress disorder, getting access to the drug isn't nearly so easy. That's because the federal government has a virtual monopoly on growing and cultivating marijuana for scientific research, and getting access to the drug requires three separate levels of approval. Marijuana offers hope for 6-year-old girl with rare condition: In marijuana, Lydia Schaeffer's family members think they might have found a treatment that works. Now, they are trying to help legalize the drug. Sisley's fight to get samples for her study — now in its fourth month — illuminates the complex politics of marijuana in the United States. While 20 states and the District have made medical marijuana legal — in Colorado and Washington state the drug is also legal for recreational use — it remains among the most tightly controlled substances under federal law. For scientists, that means extra steps to obtain, transport and secure the drug — delays they say can slow down their research by months or even years. © 1996-2014 The Washington Post
Keyword: Drug Abuse; Aggression
Link ID: 19396 - Posted: 03.22.2014


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Image: Sam Namos
A massive sealed doorway to the facility
The town of Krasnokamianka in Crimea, Ukraine is a scenic place surrounded by forested mountain slopes, gardens, vineyards, and red stone – for which the area is renowned. However, underground there is something arguably much more sinister. During the Soviet occupation, subterranean tunnels and chambers were built in Krasnokamianka to host an arsenal of nuclear weapons.
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Why HiRise?
iPad mini soars with HiRise.
If you've been looking for the perfect dock for your iPad mini as long as we have, your search is over. HiRise makes a spectacular pedestal for iPad mini. Sitting atop HiRise, your iPad mini looks absolutely gorgeous, and the speakers are wide open too. Just like iPhone, you can stream your favorite music or display your favorite photos, all while charging your device on a modern vertical perch. We think HiRise will lift the ways you use and interact with your mini.
Stream your favorite hits.
Remember when your favorite speakers also docked and charged your iPod? HiRise is a great way to keep your iPhone or iPad mini fully charged while streaming music to your favorite new Bluetooth speakers (not included). Go ahead, listen to hours of music... you'll find that big green iPhone "battery full" icon when you're ready to grab your phone and go. This sculptured metal stand looks great parked next to the most stylish Bluetooth speakers out there – or your Mac desktop setup.
Meet the whole family.
Our HiRise family is the perfect way to elevate your MacBook, iMac, iPad mini or iPhone to a more comfortable viewing height. All three HiRise models are made from sturdy steel to support, showcase and boost your Apple user experience.
"It's quite possibly Twelve South's best accessory yet."Nick Guy, iLounge
"...a great accessory for anyone looking for a nicely designed, well-constructed and convenient iOS Device stand."Mark Gurman, 9to5Mac
"Unlike most stands, the HiRise also works with cases, so you don't have to remove your case just to charge your phone."Thorin Klosowski Lifehacker
Handy desktop companion. Place HiRise on your workspace, next to your desktop setup. Keep your eyes focused on your Mac and use iPad mini for at-a-glance apps like news, stocks, weather and sports.
News and weather center. Sitting next to your desktop, HiRise uses your Lightning Cable to charge your iPhone 5, while letting you use your small screen to keep an eye on weather, news, sports or Twitter.
Excellent bedside manners. Park HiRise on a nightstand, set your iPhone 5 alarm and wake to a fully charged phone or iPad mini.
Excellent bedside manners. Park HiRise on a nightstand, set your iPhone 5 alarm and wake to a fully charged phone or iPad mini.
Headphone friendly. Notice that HiRise doesn't block the iPhone 5 headphone port or iPhone speakers. With or without headphones, your iPhone will deliver crystal clear sound atop HiRise.
Think of it as a stream machine. Look at this. Set iPad mini or iPhone 5 on HiRise and pair with your favorite Bluetooth speaker. Stream music all day long while keeping iPad mini fully charged.
Use with almost any iPhone case. HiRise adjusts to fit many of the most popular iPhone 5 cases, including the OtterBox® Defender and Speck CandyShell. Of course, our favorite case for HiRise is our own BookBook for iPhone.
Beautiful, sleek design. In this side view, you can see how this sliver of metal props up and supports your iPhone 5. See the rear support that iPhone leans against? It adjusts back and forth to fit different iPhone 5 cases.
HiRise Specs
|HiRise for iPhone/iPad mini
Height (Front Support): 1.65 inches (4.2 cm)
|What's in the box
HiRise FAQs
- Is HiRise compatible with iPhone 6/6 Plus?
Yes, HiRise for iPhone works great with the new iPhone 6 and iPhone 6 Plus!
- Can I use a different brand of Lightning cable than Apple?
HiRise is designed to work exclusively with the smallest and highest quality Lightning Cable available – the Apple Lighting Cable that came in the box with your iPhone 5, iPod Touch or iPad mini. The Apple Lightning Cable fits perfectly with the HiRise height-adjustable clips, allowing you to use HiRise with nearly any case on the market, whether it's a rugged OtterBox® Defender, a Speck® CandyShell, or our favorite -- the BookBook for iPhone.
- Can I use Apple's 2-meter Apple Lightning Cable with HiRise for iPhone?
No. The new 2 meter Apple Lightning Cable is thicker than the standard 1 meter cable (the one that came with your iPhone) or .5 meter cable, so it is unfortunately incompatible with HiRise for iPhone. If you need additional length, we recommend extending the length of your 1-meter cable instead by buying a USB extension cable instead (like this one).
- Can I use HiRise for iPhone with my iPhone 4/4S?
Sorry. HiRise is made exclusively to work with Apple's Lighting Cable, which means it's compatible with iPhone 5s, iPhone 5c, iPhone 5, iPod Touch (5th generation) and iPad mini only.
- How to assemble HiRise for iPhone [VIDEO]
- Can I use HiRise if I have the Apple iPhone 5s or Apple iPhone 5c case installed on my device?
Yep. By using the #2 clip (included with your HiRise), you can use HiRise to dock your iPhone without having to remove your Apple iPhone 5c Case or Apple iPhone 5s Case.
- Can I use HiRise with my full-size iPad or iPad Air?
We don't recommend it. While the Lightning connectors of the full-size iPad and iPad Air are compatible, their overall size is a bit too big to be stable on the HiRise.
- Do I have to remove my iPhone case to use HiRise?
No way. HiRise works with nearly any iPhone 5/5s case on the market today. You can also use your iPod Touch (5th generation) or iPad mini with HiRise and nearly any case that covers them.
- How can I know if my case will work with HiRise? (video)
Step 1: While connected, use your thumb to mark the visible portion of the lightning cable
Step 2: Measure from your mark to the top of the white overmold of your cable
Step 3: If it measures 5mm or less, your case is compatible!
- Does HiRise block access to the headphone jack on my iPhone?
No. Unlike cup holder type docks, HiRise elevates iPhone so you can easily use the headphone jack.
- Does HiRise muffle my iPhone speakers?
Nope. Having iPhone elevated on HiRise means your speakers will sound just like Apple intended them too. Sound won't be blocked, distorted or muffled as it would with a drop-in style dock.
- Why does HiRise use the Apple Lightning Cable?
HiRise for iPhone/iPad mini uses the Apple Lightning Cable exclusively. It's the cable that came with your Apple iPhone 5, iPad mini or iPod Touch (5th gen.) Here's why:
The Apple Lightning Cable is the secret to using HiRise with practically any case. The HiRise height-adjustable clips, along with the Apple Lightning Cable, means HiRise can work with practically any case on the market today–especially cases with recessed connections that no other dock can fit.
All Lightning Cables are not created equal. Exclusively using Apple's Lightning Cable allows us to create a perfectly-fitting dock with the smallest and highest-quality Lightning cable we know of–the Apple Lightning Cable you already have.
It makes the best possible desktop stand. Most users have additional specialized Lightning cables, such as car chargers or shorter travel cables. This leaves an Apple Lightning Cable at home. Installing an Apple Lightning Cable into HiRise turns your already-stationary cable into a beautiful, convenient desktop dock.
- How do I identify the Lightning cable clips and insert them into HiRise? (photo)
Each Lightning cable clip has a number imprinted on the bottom of the clip. These numbers represent the additional height it will provide your Lighting cable if using HiRise with an iPhone that has a case installed.Click here for a handy graphic showing how to identify each clip and insert them into HiRise.
- What is the benefit to keeping my iPhone on a HiRise?
HiRise for iPhone is a perfect way to charge and sync your Lightning-based iPhone, iPod Touch (5th generation) or iPad mini, while using nearly any case that covers them. HiRise is small enough to use at your workspace or anywhere in your home or office. Plug your Lightning Cable into a wall outlet for charging or plug it into your iMac or MacBook to charge and sync your phone using HiRise.
- Can I undock my iPhone from HiRise with one hand? (video)
Yep, check out the video below:
Although you can undock your iPhone 5 from HiRise with one hand, we do recommend using two hands when undocking an iPad mini from HiRise.


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You Don't Understand The Boundary Between Teasing And Abuse
Light banter is fun. Downright lovely, in fact, when you pick up on the tiny little eccentricities I didn't think anybody cared enough to notice. But you really, really don't understand where the limit is. Yes, it's embarrassing that I have a Justin Bieber song on my iPod. But scrolling through every artist I adore whilst proclaiming I have absolutely no taste in music whatsoever is a little too harsh for my liking. And yes, when I was little I had hamster cheeks like no other. Mock them all you like. But asking how such a disgusting whale grew up to be such a fox isn't actually as flattering as you seem to think. Oh, and next time a girl gets close enough to you to tell you she once attempted suicide? Here's a handy tip - don't tell her she's "so fucking emo", ok?
Written by Laila.


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20 North Bridge, EH1 1TR, Edinburgh
Tel: +44 (0)131 556 5565 - Fax: +44 (0)131 652 3652
Stay with us at The Scotsman Hotel & North Bridge Brasserie for a boutique Christmas. Experience a five-star break, with all your meals meticulously prepared by Executive Head Chef Paul Hart, including an extravagant six-course meal on Christmas Day.
Join us at The Scotsman Hotel & North Bridge Brasserie for an extravagant New Year's Eve celebration. Enjoy a five-star break, with all your meals meticulously prepared by Executive Head Chef Paul Hart, including an extravagant six-course gala dinner on New Year's Eve.
Enjoy a trip to The Scotsman Hotel & North Bridge Brasserie for a two-night break full of fine food and retail therapy. Plus, enjoy free access to our health spa & fitness club, as well as 25% off any spa treatments.
Join us at The Scotsman Hotel this festive period for an unforgettable Christmas party. Enjoy a delicious three-Course meal of gourmet Scottish delicacies, and then dance the night away with friends and colleagues.
Throughout December, the North Bridge Brasserie will be serving festive-themed afternoon tea, perfect after a hard day of Christmas shopping. Executive Head Chef Paul Hart creates a new afternoon tea menu every day, but you can be sure that everything on the menu will have its own unique Christmas twist.
For the entirety of December, the North Bridge Brasserie is serving delicious Christmas lunches full of festive Scottish Cuisine, carefully crafted each day by Executive Head Chef Paul Hart. Expect a new menu every day, as Chef Hart creates delightful delicacies using only the freshest locally-sourced ingredients.
Join us at the North Bridge Brasserie throughout December for one of the Scottish Capital's most stylish dining experiences. Executive Head Chef Paul Hart is renowned for creating a new menu every day, so you can be sure of a unique Christmas dinner, complete with festive sparkle.
Stay with us at The Scotsman Hotel & North Bridge Brasserie for a boutique Christmas. Experience a five-star break, with all your meals meticulously prepared by Executive Head Chef Paul Hart, including an extravagant six-course meal on Christmas Day.
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Enjoy a trip to The Scotsman Hotel & North Bridge Brasserie for a two-night break full of fine food and retail therapy. Plus, enjoy free access to our health spa & fitness club, as well as 25% off any spa treatments.
In association with Ultimate Golf Service we've created an excellent short-stay Edinburgh golf break. Enjoy a round of golf on one of Edinburgh's fantastic parkland courses, including Prestonfield and Duddingston, along with bed & breakfast at The Scotsman Hotel, all for as little as £145.
The Scotsman Hotel has joined forces with Ultimate Golf Service to bring you a fantastic short-stay golfing holiday. Enjoy a night at the Iconic Scotsman Hotel, followed by a delicious breakfast and a round of golf at one of a selection of the finest links courses in the region, all for as little as £170.
Five-star Bed & Breakfast at the Scotsman Hotel. This Best Guaranteed Rate cannot be found cheaper anywhere else online. Book Directly with this Website for the best possible deal available anywhere online.
The Scotsman Hotel have created a truly indulgent experience, perfect to pamper yourself or a loved one during a five-star stay in Edinburgh. Tempting treats include delicious dinner at the award-winning North Bridge Brasserie, Champagne breakfast and a luxurious Scotsman Spa gift bag.
Let us show you and your partner the romantic highs of Edinburgh with this luxury overnight break for two. Experience the finest Champagne, homemade chocolates… and some of the finest cuisine in the city – all served up in exclusive 5-star fashion at our Baroque hotel in Edinburgh's stunning city centre.
Take a stunning two day break in Edinburgh and indulge in the luxury trappings of our five-star hotel, complete with full Scottish breakfast on both mornings... and a three course dinner in our North Bridge Brasserie.
The Scotsman Hotel is proud to be able to offer a selection of three outstanding tours for those looking to get the most out of their Edinburgh stay. Experience the history of old Edinburgh; revel in the spooky vaults of the Old Town; or discover the intimate secrets of the famous Royal Mile. All this, plus a five-star stay for two in our luxury hotel.
If you looking for a superb rate for a luxury bed and breakfast weekend or week day break away then this excellent offer is perfect for you and your family and friends. Enjoy a fantastic full Scottish breakfast following a stay in one of our beautiful rooms or suites, perhaps even treat yourselves to breakfast in bed - Scotsman Style!
Experience a luxury two night getaway in Edinburgh. Enjoy the very best Edinburgh has to offer then retire to our traditional five-star hotel for a stunning serving of Afternoon Tea and some of the finest amenities in the city.
Experience the magic of Scotland with this outstanding tour and luxury stay offer. Enjoy two nights of boutique luxury; including all the trappings of our in-house spa, a three course gourmet meal for two in the North Bridge Brasserie... along with a look at traditional Scotland on this once in a lifetime tour.
This special online rate from the Scotsman Hotel offers you a fantastic room only rate, along with a free £10 voucher to spend in our North Bridge Brasserie. You won't find this deal anywhere else online. Rates start at an oustanding £135 for an exclusive night of five-star luxury.
Congratulations! By booking directly with us you can rest assured you will be receiving the best rate The Scotsman has to offer. With this offer you have the opportunity to choose one of our unique and original rooms that suits you perfectly. From a wood panelled room, roll top bath or king size bed we have everything to make your stay perfect.
The Scotsman Hotel, in conjunction with its luxury in-house Spa, has put together the ultimate overnight Spa package. Luxuriate in the decadent surroundings of our state-of-the art spa, dine in our award winning restaurant… and let us simply pamper you with five-star luxury.
Two fantastic days and nights in Edinburgh, including: dinner in the award winning North Bridge Brasserie, a traditional Scottish breakfast every morning and a selection of treatments in our state of the art Spa. If you're looking to explore the sights of Edinburgh… then relax in luxury every evening, this is the perfect package for you.
You could save up to 15% by booking early at The Scotsman Hotel. Enjoy one of our fabulous rooms or perhaps upgrade to a luxury suite at a special rate. When you know your plans ahead of time it makes relaxing and enjoying them so much easier; you can truly look forward to your "Scotsman" experience with us.
Sunday nights at the movies! Always a great way to enjoy a lazy Sunday evening but why not make it extra special by treating yourselves to an overnight stay with us after enjoying a matinee showing of a great classic film. A 1 night stay including dinner, flowers and Champagne as well as tickets to our private cinema.
Take a relaxing break at the Scotsman Hotel and indulge in one of the finest Afternoon Tea's in Edinburgh. This offer gives you one night of five-star luxury, traditional, or gluten-free, Afternoon Tea and a full Scottish breakfast in the morning.
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42, The Calls, LS2 7EW, Leeds
Tel: +44 (0)113 244 0099 - Fax: +44 (0)113 234 4100
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Kaerntner Ring 9, A-1010, Vienna
Tel: +43 (0)1 515 800 - Fax: +43 (0)1 515 80 10
Experience a 'crowned' holiday with an 'imperial' stay at the Grand Hotel Wien. With the Habsburg Highlights Package you will stay two nights at the 5-star De Luxe Hotel that, in the early times of its 140 years history during the then Austrian-Hungarian Monarchy, regularly was visited by members of the Imperial family.
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9 rue Balzac, 75008, Paris
Tel: +33 1 42 99 80 80 - Fax: +33 1 42 99 80 40
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Universal Tuition Tax Credits
Universal Tuition Tax Credits, called UTTC for short, is a system by which parents pay the school their son or daughter attends and, in turn, school tuition is deducted from the state income taxes of the parents making the payment. The result: students who normally wouldn't have the opportunity to attend a school other than the one located within their district are given that opportunity because of the UTTC-based system. UTTC, unlike school vouchers, would not allow state funds to support religious schools, drain any funding from public schools, or spawn new entitlements in private schools. Instead, Universal Tuition Tax Credits will take less than 10% of students in public schools and aid them in migration to private or home schools—the schools that they or their parents want them to attend. This system saves state and local governments large sums of money while also providing a quality education to students in a setting of their choice. Students and parents alike are thereby empowered to take a proactive role in the education process. It isn't only the UTTC recipients and their families who benefit, however. Public school students benefit, too, via smaller class sizes, higher per pupil spending, and increased teacher competition. Parents of UTTC enrollees would receive a dollar-for-dollar reduction in state income tax liability for every dollar spent on tuition. Money from the tax credit could simply be claimed against state tax liability. Deductions could include books, supplies, computers, tutors, tuition, and transportation.In the end, parents and students—public, private, and alternative alike—win with a UTTC system. When school choice is made more accessible to parents and students, the quality of education, the ability to take personal responsibility, and the availability of quality schools for all social classes climbs dramatically.
- It's Time for a Change in DC's Schools 02/2002
- Tuition Tax Credits: A Model for School Choice 12/2001
- Hard Numbers On Tuition Tax Credits 10/2001
- The Arizona Scholarship Tax Credit: Giving Parents Choices, Saving Taxpayers Money 09/2001
- Arizona School Choice Plan Serves as Model 08/2001
- Fiscal Analysis of a $500 Federal Education Tax Credit to Help Millions, Save Billions 05/2001
- Pennsylvania's New Universal Tuition Tax Credit Legislation 05/2001
- Education Tax Credits Could Give New Hampshire Parents, Students More Choice 04/2001
- Achieving Excellent Schools Without a Tax Increase: A Plan for Virginia 09/1999
- The Universal Tuition Tax Credit: A Proposal to Advance Parental Choice in Education 11/1997
School Vouchers
In a school voucher system, all designated students would receive vouchers for a specified amount of money good at any school—public, private, or alternative. The school admitting the student would then redeem the voucher for payment. Depending upon the amount of the voucher, the students' tuition bill would be partially or fully paid by the local or state government.
Universal vouchers would allow all parents to direct funds set aside for education by the government to send their children to a school of choice, whether that school is public, private or religious separates the government financing of education from the government operation of schools. Means-tested vouchers enable income-eligible families, usually in limited numbers, to direct funds set aside for education by the government to pay for tuition at the public, private or religious school of their choice.
- When Schools Compete: The Effects of Vouchers on Florida Public School Achievement 08/2003
- Vouchers for Special Education Students 06/2003
- Lessons from Florida: School Choice for Students with Special Needs 03/2003
- Graduation Rates for Choice and Public School Students in Milwaukee 09/2001
- Lessons from Vermont: A Voucher System that Works 09/2001
- Lessons from Maine: Educational Vouchers for Students Since 1873 09/2001
- An Evaluation of the Cleveland Scholarship Program 09/1997
- What Would a School Voucher (Really) Buy? 03/1996
Charter Schools
Charter schools are publicly funded schools that are granted a high degree of autonomy from existing rules and regulations. Depending upon state law, teachers, parents, or other would-be educators can apply for permission to open a school. The "charter" may be granted by, for example, the local school board, the state board of education, or a public institution of higher education, depending upon the state. Some states also allow existing public or nonsectarian private schools to convert to charter status. Charter schools have the potential to control their own budget, staffing and curriculum, but their autonomy varies from state to state. They must attract students and achieve the results agreed to in their charters, or their contracts can be revoked.
Charter schools are semi-autonomous public schools, founded by educators, parents, com


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Posters, Wednesday, May 1
Deadline for Posters is 5 p.m.
• Cancelled: Council Committee meeting scheduled for today, May 1, to discuss Land Development Ordinance Text Amendment. Notice will be posted when new meeting date is determined.
• AARP will have a meeting on how to read your Medicare Summary Notice/Spotting Fraud, Rufty-Holmes Senior Center, Thursday, May 2 12:30 p.m., refreshments after meeting.
• Chicken or fish dinners, Friday, 11 a.m. until, at Faithful Guide Lodge 376, 113 Krider St., Cleveland. $8 plate includes chicken or fish, baked beans, slaw, dessert. Carry-out, call 704-902-4092 or 704-450-1454.
• Stowe A-Way for a Day and Concert by Night, May 4, food 11 a.m.-5 p.m., $8-$15. 6 p.m. concert. Mt. Olivet United Methodist Church, 301 Mt. Olivet Road, Concord, www.mtochurch.com


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It has been a long eight months for Shahnaz Nahai, living months in fear after she was the victim of one of America's most notorious cat burglars.
On Tuesday, Nassau County, FL sheriff's deputies arrested Blane David Nordahl, 51, on two warrants out of Atlanta.
Elizabeth Music, Nordahl's girlfriend, was also arrested by deputies as a co-conspirator. Police say she helped plan some of the heists.
"He left no prints, nothing - no dirt in the house, nothing," Nahai said.
Nahai hosted a party on New Year's Eve and used the silver at that party. On Jan. 3, she realized it was missing.
"I was trying to set the table for a party we were having, and I kept opening drawers and opening cabinets and I couldn't understand where all the silver had gone," Nahai said.
She looked around the house for an hour, trying to find where the burglar broke in. Nahai's home is equipped with a security system that included motion detectors and glass break detectors. It wasn't until her son came over and saw the two panes of a glass door intricately removed.
"He didn't break any glass or open the window so it never blew the alarm," Nahai said.
Police said Nordahl uses the same technique for nearly all of his burglaries. He strikes while the victims are sleeping, entering through small cut-outs he makes in windows, and sometimes door frames.
The way police said Nordahl entered homes, without tripping the alarms is what led him to years of not getting caught.
"It was very unique," Atlanta police Detective Drew Bahry said. "I've never seen it before. Detectives that I have worked within other jurisdictions that have been on 25 to 30 years have never seen it before."
According to the New York State Department of Corrections and Community Supervision, Nordahl was released on parole in Nov. 2010. In that time, investigators believe he hit 56 homes across six states.
The estimated value of silver stolen is between $6 to $7 million. Atlanta had the most cases with seven burglaries and an estimated value of stolen silver at $1.5 million.
Other cities hit in Georgia were Macon, Athens, Columbus and Thomasville.
Investigators said they are working with detectives in Belle Meade, TN and Charleston, SC, for additional victims.
"It's just the sterling, he has a great knowledge of what's real," Bahry said. "Every house we went to the plated silver was left, there was a ton of plated silver left, it was just the solid stolen."
Investigators said Nordahl would steal an average of $20,000 worth of silver in a single burglary.
"He didn't take silver plates," Nahai said. "The silver plate was right next to the sterling."
Nahai estimates some of her silver dated back 300 years and were family heirlooms that can't be replaced. She is holding out hope that all of it wasn't just melted down, something police believe Nordahl was doing.
"What and the hell have you done with my silver?" Nahai said she would ask Nordahl. "And how dare you do this? How dare you come into my house, and take all my things and all of my family heirlooms. Where is it? I am will to pay to get it back, I am willing to pay to get it back."
According to police, Nordahl is a high profile cat burglar. Nassau Sheriff Bill Leeper said his criminal history is extensive.
"'The Silver Thief' and 'Burglar to the Stars,' made his living pilfering expensive silver items from fancy homes across the east coast of America. He is believed to have netted $3 million in around 150 burglaries throughout his criminal career. Despite his professional approach to burglary, he has been caught numerous times, and served an 8-year sentence after being convicted of stealing $50,000 worth of silver cutlery from the home of Ivana Trump. Other notables he stole from are sportscaster Curt Gowdy, and musician/singer Bruce Springsteen," Leeper wrote in a news release.
Nordahl and guest will be extradited back to Fulton County where they face will charges of Burglary with Intent to Commit a First Degree Felony and Conspiracy to Commit a Felony.
Nordahl is a well-known silver thief who even has his own Wikipedia page.
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Posted this on Whitearmor.net, but I figure I'd share this build here as well, since it's my latest baby!
[FONT=Helvetica Neue, Arial, Verdana, sans-serif]Vacuum formed this out of 0.06 HIPS, out of an original hand-made mold I made out of bond; mask is actually made in 3 major parts: (silver) outer shell (out of which the detailing was cut), which is glued over the inner mask (dark grey), and middle ridge/diamond section above the nose, which was glued on top of it all.
[FONT=Helvetica Neue, Arial, Verdana, sans-serif]The step-by-step diary with photos is posted on whitearmor, but I also made a youtube video that basically sums everything up in under 3 minutes.
[/FONT][FONT=Helvetica Neue]
Sith Acolyte Warrior Mask Star Wars the Old Republic SWTOR fan-made - YouTube


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Sparrow Beta 5
Labels! Here they are!
Thanks for your patience.
Label implementation on Beta 5 is really basic but be sure that we will add a lot more useful features in the next release.
Sparrow Beta 5 will begin a new full sync between your gmail account and your Mac. Labels will be the last thing to sync so don't panic if they don't show up right away.
The app should be syncing for some time at first launch. We had to do this in order to improve Sparrow's behavior and overhaul performance.
New features
General improvements
Bug fix
We've done a lot more than what you see in Beta 5. We've got to surprise you with Sparrow 1.0.
Beta 6 will be the last Beta. After this, Sparrow will go 1.0.
Thanks for following.
Go and get Sparrow Beta 5 for free here.
posted 11 November, 2010
Follow on Twitter
Scaffold theme by Mike Harding.


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Rec Sports and Intramurals
About rec sports at EMU
Rec sports, or intramurals, are a HUGE part of life on campus at EMU. Our recreation sports director is dedicated to providing a modern program of sports for students and faculty, and participants enjoy positive recreational activities that appeal to a wide variety of people.
Rec sports allow students to relax, disconnect from strenuous academic schedules, and develop skills that can be used after their university experience. They also build a sense of teamwork while making new friends and establishing social contacts.
What can you do?
Come join us in the game room, on an intramural sports team, working out or taking a class in the Fitness Center, or making it to the top of the rock climbing wall!
Open recreation and general use of the gymnasium is open to EMU students, faculty, staff, their dependents, and fitness center members. (Dependents under the age of 14 must be directly supervised by their parent/legal guardian.)
Contact info
Fitness Center
Call the front desk at 540-432-4341 or contact Jeff Tyson, fitness center operations coordinator, at 540-432-4331.
Rec and Intramural Sports
Email or call Phil Tieszen, recreation sports director, at 540-432-4644.
Game Room
Call the front desk at 540-432-4375 or contact game room coordinator, Phil Tieszen, at or 540-432-4644. The game room is closed during the summer, except for special events.
Rock Climbing Wall
Contact physical education instructor Lester Zook at 540-432-4439 or .


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PHH Mortgage Jobs in Kansas
Currently, there are no PHH Mortgage jobs available in Kansas. You may wish to explore other locations on the PHH Mortgage jobs page or view related jobs below.
POSITION SUMMARY: Ensure all Mortgage Collection call center activities meet department, client, and investor expectations as well as service level agreements. Manage daily inbound and outbound call volumes to enhance agent efficiency and productivity. Assist management with ensuring all collection efforts are strategic in nature while striving for constant improvement relative to strategic diali...
The Loan Processor position plays a critical role in the client experience. Clients include borrowers and other third party stakeholders such as financial advisors and real estate agents. After completion of the loan application, the Loan Processor directs the remainder of the mortgage process as the client?s primary liaison/key point of contact. Loan Processors build and manage client relationshi...
JOB FUNCTIONS: ? After completion of the loan application, the loan processor guides the customer through the home financing through to closing. ? Translates and coordinates event logistics, such as investor loan requirements and scheduled events as they relate to home financing. ? Sets appropriate customer expectations to meet turnaround times on the receipt of the application package and trai...
Become a key member of the DLD team! This challenging position involves management of various legal documents necessary within bankruptcy and foreclosure actions. Employees are required to successfully complete annual mandatory training requirements and department specific training, as defined by management. Responsibilities include:? Work closely with the outsource vendors, PHH assigned law fi...
PHH Mortgage provides outsourced, private-label mortgage solutions to clients nationwide who are leaders in their fields of business, including financial institutions, real estate companies, credit unions, corporations and government agencies. In 2011 alone, we closed nearly $52 billion in mortgage financing. The success of our outsourcing model has enabled PHH Mortgage to become one of the top 10...
This role is responsible for originating loans and supporting the Ohio branch. The Mortgage Sales Consultant is the initial point of contact for clients and is responsible for managing inbound call leads that are received in order to effectively sell mortgages and other products. Originate loans to achieve sales forecasts, sales targets and sales penetration rates. The Sales Consultant provides p...
Position Title: Collections Representative I POSITION SUMMARY: Negotiate payments with borrowers who are delinquent with their mortgage loan payments or review their financial situation to determine eligibility for retention or liquidation of their home in order to mitigate losses for the company and/or investors. ESSENTIAL FUNCTIONS AND RESPONSIBILITIES: Attempt to contact, via telephone, all...
Didn't find the right job at PHH Mortgage in Kansas?
We'll keep looking and send you new jobs that match this search.
Upload your resume and let employers find you!
It's that simple!
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Stella McCartney
'Bonnie Sizzling' Underwire Bra
|Item # 616154
(Available every day, from 7am to 1am Eastern.)
Details & Care
Sheer floral lace decorates an utterly romantic long line bra designed with vertical seaming on the underwire cups that helps give the figure a lifted, youthful silhouette.
- Nylon/elastane; hand wash.
- By Stella McCartney; imported.
- Lingerie.
Watch the video: Bra Fit Video


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Night Therapy 14" Deluxe Grand Memory Foam Mattress - King
by Night Therapy | Item #: 747945 | (36) |
Night Therapy's deluxe hi profile mattress, the finest in luxurious comfort and support.
Enjoy the best night's sleep with deluxe firm support. Feel the luxury of a hi-profile mattress with premium memory foam at an affordable price. Exclusive layered memory foam and pressure relief foam that eliminates pressure points in three important areas:
- Head & Shoulders
- Hips
- Feet
- Cream color polyester jacquard cover is quilted with fiber padding, and 1" of memory foam for ultimate body contouring comfort
- Tan base layer cover is quilted with fiber padding. The body core is the unique pressure relief layered system of 2.5" memory foam, 3.75" of super soft pressure relief foam, 3.25" of multifaceted foam, 3.5" high density foam to provide long lasting durability and stability
- The foams are infused with Green Tea, Charcoal, and Natural Seed Oil which minimizes the use of petrol based chemical oils, working to eliminate chemical odor and to minimize growth of bacteria in a natural way
- Night Therapy Real Mattress® in a Box embraces the idea of "Sleep Green" so that the comfort of your sleep environment is balanced with ingredients that are safer for you and the environment we all share
- The ingredients used in this product were selected with sustainability in mind
- Natural Green Tea Extract is a natural odor protectant
- This product is packaged in a box that has a smaller carbon footprint and is made with 45% recycled materials
Assembled Country
Assembled Size
King 76" x 80"
Component Country
Ask & Answer
Shipping Information
Warranty InformationMattress - 10 year prorated limited warranty covers manufacturing defects
There is no additional information available for this item.


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Civilization: Beyond Earth videos show how aliens will react to human presence
Firaxis took to Twitch to stream 50 minutes or so of Civilization: Beyond Earth, in part focusing on how the indigenous (or, to us, alien) species in the game will react to the presence of us fleshy human meatbags. These creatures will essentially perform a lot of the same functions as the barbarians from Civ, but Firaxis were quick to point out some key differences. We also get to ogle at the game's lovely new Tech Web (it's no longer a tree), which is a thing of interconnected, very purple beauty. The session is now on YouTube, and I've linked all three parts below.


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Comparison shopping sites not wicked after all, says Google
Google is adding "AdWords Comparison Ads" to its armoury of weapons designed to squeeze even more money out of advertisers "make ads more relevant and useful". The ads will list prices and features for multiple products from paying advertisers on a single page, thus making it easier for shoppers to find the best deal without …
now refined and better ....mmm NuTruth tm
(warning:may not run on all versions of logic, not backwards compatibe with Truth 1.0. NuTruth copyright Google. guarenteed Evil free. No UmpaLumpas were harmed during production)
Wouldn't Google's own Froogle fall foul of these rules and be classed as a low quality site?
It is gravely annoying to use Google to look up some product or other, to find only shopping comparison sites, and, quite often, no actual shops. Sometimes, as they say, a comparison of comparison sites. Most of all to look for reviews of, say, the Asda Bloody Awful Digital TV Set Top Brick (no longer on sale), and get 100 Google results from shopping comparison sites saying "Be first to review Asda Bloody Awful Digital TV Set Top Brick (no longer on sale)". The text itself is stolen from another shopping site, I expect. Damn them to hell, and while I have mixed feelings about Google providing useful service to me while making its money from people paying them for premium-attention access to my eyeballs, at least they aren't being paid by these filthy scum.
Bing, Bing,
Bing goes the in'ernet...
Damn. I think I am going to have to sue The Reg for permanently damaging my brain...
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Friday, 04 October 2013 08:43
McALLEN – The International Museum of Art & Science (IMAS) will present their latest exhibit "Quantics: The Art & Science of Sebastian" with an opening reception on Thursday, Oct. 10, at 6 p.m. The exhibit will be on display through March 2, 2014.
In this exhibit the world-renowned sculptor Enrique Carbajal, better known as Sebastian, explores the worlds of quantum physics and nano particles, and combines them with his love for clean and geometric aesthetics.
"Quantics" is more than just an art exhibition. It transcends the museum's interactive Discovery Pavilion, the Science On a Sphere Theatre, the museum grounds, and the streets of McAllen; thus, demonstrating the fusion between art and science and their dependency on one another for inspiration.
Read more: 'Quantics' exhibit by sculptor Sebastian opens Oct. 10


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Beauty of the Father
A play by the Pulitzer Prize winner Nilo Cruz. Set in Andalusia, Spain, where the restless ghost of the Spanish poet Frederico Garcia Lorca still wanders through the streets and converses with the living.
Where: James A Little Theater
Phone: 505-476-6429
1060 Cerrillos Road
Santa Fe, NM


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"You want to engage with your wife throughout the day to reinforce your comfort and security," said author Steve Schloss.
Schloss talked to Good Day about his book "The Man's Secret To A Happy And Sexy Marriage."
Schloss advises, for example, tell her you love her before you leave for work, and maybe send her a cute text about something that happened last night later on in the day.
"It can be something that happened with the kids last night, a great dinner she made. Show women you appreciate them. You adore them. You admire them," Schloss said. "Check in throughout the day."
This is called the one percent rule.
"Look at all the time you spend on social media, talking to go guys about sports. One percent of your waking hours is 9.6 minutes. Ten minutes a day," Schloss emphasized.
Remember this, Schloss says, a woman needs to feel:
Mike Jerrick then asked Schloss if he's married, and Schloss revealed that he was married.
"I'm in a wonderful relationship now. You learn. People say, 'how can you be writing this book if you are in the married.' you learn from your experience," said Schloss.
Try to develop a new habit slowly. Just start doing a little a day.
What is the most powerful aphrodisiac? Schloss says it's to have fun together as a couple.
"The one percent rule is to keep the embers burning and when have great time together, that is when it is flames."
Join FOX 29's Mike Jerrick and the Good Day Philadelphia team for a tasty night of yummy treats benefiting local youth.
FOX 13 / WTVT-TV3213 West Kennedy Blvd.Tampa, Florida 33609Main: (813) 876-1313Newsroom: (813) 870-9630Fax: (813) 871-3135


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Town Clerk
Welcome to the online Town Clerk's Office.
The Town Clerk has served as the official "Keeper of the Record" for the Town since the mid-1700s and continues to be the conduit between our residents and the Town Board. The Town Clerk is an elected position and serves a two year term.
The Clerk's Office is the "entryway to local government" and is responsible for The Freedom of Information Law. A free society is maintained when government is responsive and responsible to the public. The people's right to know the process of governmental decision making and to view information leading to determinations is a basic tenet of our society. I will do everything within the law to support the public's right to know.
Our staff issues marriage licenses, hunting licenses, fishing licenses and dog licenses and various permits. Notary services are provided free of charge. The Town Clerk is also the registrar of Vital Statistics.
Marriage ceremonies are performed during regular office hours. Weekend and evening services are by appointment only.
Harrison has the premier dog park in Westchester. Entry permits can be obtained at our office for a nominal fee. Please make sure your dog's shots are up to date prior to coming in for your entry permit.
One of my goals is to make the Town Clerk's office accessible to all of our residents. Please visit our office, located on the first floor of Alfred P. Sulla Municipal Building, One Heineman Place. There you will find my courteous staff ready to assist you in obtaining the services that you require. If you have a medical problem or a special circumstance that makes it impossible to use our in house services please call my office so I can provide special assistance at your home.
The Clerk's Office hours are 9:00 am to 5:00 pm Monday through Friday from Labor Day through Memorial Day and 9:00 am to 4:00 pm during the summer. In an effort to provide service to residents who are unable to come to the office during regular business hours the Clerk's office will be opened from 7:00 pm to 8:30 pm every fourth Tuesday. The new hours will coincide with the scheduled Planning Board meetings thereby saving the cost of opening the building and eliminate the need for providing the required evening security.
Again, welcome to our on line service. If you can't find the answer to your question here or if I can be of further assistance please don't hesitate to contact me at (914) 670-3030.
It's great to live in Harrison!
Jackie Greer
Staff Contacts
|Jackie Greer
|Town Clerk
|Maggie Mauro
|Deputy Town Clerk
|Diana Minishi
|Senior Clerk
|Nancy Piccini
|Archives Clerk
Contact Info
Monday - Friday 9:00am - 5:00pm
Summer Months Monday – Friday 9:00am - 4:00pm
Evening Hours 4th Tuesday of Every Month - 7:00pm to 8:30pm
House Calls are available by appointment.
Email: firstname.lastname@example.com


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Behind the Cover: Natalie Portman
Natalie Portman was all about channeling quite the feminine, fantasy-meets-reality couture vibe for her November cover shoot. Now you can get the cover look yourself, right here.
Cover Interview | Cover Shoot | Behind the Cover: BeautyOctober 15, 2013 9:00 AM
Ruby Sparks
DRESS $2,190, Christopher Kane; colette.fr for similar styles.


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Quick Disconnect Mounting Kits
The Tempress Quick Disconnect Mount is truly an original. No other seat mount on the market provides the functionality and features of the QD Mount. The QD mount will work with the All-Weather and Profile Seat Shells and allows them to swivel and easily be removed from the mount disk. The low profile mount will install on any flat surface with 4 screws (not provided), it is great for bench seats or engine boxes. The kit includes the mount, adapter plate for the seat bottom, (plus hardware to attach), and the locking flap. QD Mount does not work with the Tempress NaviStyle seats or any other manufacturer's seat.
Boat Seat Quick Disconnect
We all have those times with our boats when we wish it was easier to add and remove the seats. Like when there aren't quite enough seats for the the kids who came on the fishing trip, or when the boat seats deteriorate in the winter weather and it would have been nice just to take them off and store them in the garage. Well, the Tempress Quick Disconnect mount is the solution to these sorts of issues. The Tempress Quick Disconnect mount is perfect for all the fishermen out there. It is a low profile, quick-disconnect boat seat mount lets you add extra seats on your boat as needed or remove them for extra space with the push of a button. The mount can be installed on any standard fishing boat seat pedestal to any flat surface with 4 screws. The Quick Disconnect works with the highly rated Tempress All-Weather folding seats and Profile boat seat shells. Also, it comes in a few colors to match your boat.
This product ships in 1 to 5 business days.
Add to Cart and enter your Postal Code to determine the shipping charges and estimated delivery date.
* Most products and orders leave our warehouse in 1 business day. However, select items may take more processing time. Alaska and Hawaii orders please add 1 additional warehouse processing day.
Standard Shipping Policies


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Please verify that this program is approved for credit in your state before registering.
We hope for the 2014-2015 version to be available online in the Fall.
Recommended Desktop Browsers: Firefox (version up to 18; version 19 is not supported), Internet Explorer (version up to 10; must be in compatibility mode when using 10), Safari (version up to 6), and Chrome (up to 13). Note. The course will not work in iPads, phones, and other mobile devices.
Other Software: Latest Adobe Flash player, available for free at http://get.adobe.com/flashplayer/
OverviewThe Appraisal Institute's 2012-2013 15 Hour National USPAP Equivalent Course is approved as an online equivalent by The Appraisal Foundation and the International Distance Education Certification Center (IDECC). The course covers the 2012-2013 USPAP, copyrighted by The Appraisal Foundation, and meets all content requirements specified by the Appraisal Standards Board (ASB) and the Appraiser Qualifications Board (AQB).
Overall Learning Objectives
The module objectives are incorporated into the overall objectives for the Appraisal Institute's 2012-2013 15-Hour Equivalent USPAP Course as identified below:
Pre-Course Quiz: Testing Your Current Knowledge of USPAP
Module 1: Introduction to USPAP
Module 2: USPAP Definitions
Module 3: PREAMBLE and When USPAP Applies
Module 4: ETHICS RULE and COMPETENCY RULE
Module 5: SCOPE OF WORK RULE
Module 6: JURISDICTIONAL EXCEPTION RULE
Module 7: STANDARD 1 - Real Property Appraisal, Development
Module 8: STANDARD 2 - Real Property Appraisal, Reporting
Module 9: STANDARD 3 - Appraisal Review, Development and Reporting
Module 10: STANDARDS 4 - 10
Module 11: Statements and Advisory Opinions
Post-Course Quiz: Testing Your Knowledge of USPAP
Module 12: Conclusion and Final Exam Prep
Overview:The principal objective of this course is to familiarize participants with the Uniform Standards of Professional Appraisal Practice (USPAP). An electronic copy of the 2012-2013 USPAP document, known as eUSPAP, is provided and is referred to throughout the course. As you proceed through the course you will discover that impartiality is an integral part of what defines an appraiser. The course emphasizes the appraiser's role and how impartiality is associated with that role under various assignments—the very types of assignments appraisers perform in everyday practice.
This course is an introduction to USPAP, and therefore many in our class will be focused on assignments that involve the appraisal of real property. However, USPAP extends to assignments involving the appraisal of personal property, and business or intangible assets, in addition to appraisal review and real property appraisal consulting. A clear understanding of USPAP fosters both ethical behavior and competent practice in these appraisal disciplines.
The Appraisal Foundation has placed an emphasis on illustrating USPAP application in real-world examples. This course fulfills this requirement with practical examples, pre- and post-course diagnostic quizzes, problem-solving exercises, and multimedia case studies.
The course includes a 1-hour exam proctored at a Pearson national testing facility.
Do I have to take the 1-hour course exam?
You are required to complete and pass the proctored offline exam if:
You may be required to complete and pass the proctored offline exam if:
You will have 90 days from the time that you complete the course to take the proctored exam. Testing center locations in your area can be found by clicking on this link: www.pearsonvue.com/ai.
AI CE Credit for Designated members, Candidates for Designation and Practicing Affiliates
• Attend Only = 70 points
• Attend and Pass Exam = 75 points
Note: Access to the online program is available approximately one hour after registration.
Course price includes an electronic copy of the 2012-2013 USPAP (e-USPAP), which is available as a download once the class begins.


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Wombats City Hostel Munich
Real Reviews
Real reviews from fellow travellers
These are trusted reviews from guests who have actually stayed here. We hope you find them helpful.
Note: we only give a property a rating once it has received a minimum of 3 reviews.
- " i liked the daily tours and trips they provide... "
- 10 Sep 2014 shady Egypt
- " Absolutely the best hostel I've ever stayed! "
- 21 Aug 2014 Anonymous Poland
- " Reception staff were very accommodating and friendly, cant say the same about the bar staff ; ( really enjoyed my 2 night stay in WOMBATS. Breakfast was really nice. Great atmosphere with all the travellers in the bar. Felt very safe there. Would be great to have the toilet and shower separate as when there are 10 people showering and someone needs the loo... Legs are crossed ; ) Overall great hostel, keep up the good work and bar staff ..... Smile ...its free "
- 21 Aug 2014 irene Ireland
- " Super clean, great location, helpful staff. The rooms are quite big, too. The WiFi is okay, a bit spotty but better than other hostels I've stayed at. "
- 13 Aug 2014 Anonymous USA
- " I really didn't spend a whole lot of time in the hostel, but it was a great location, literally right across form the hauptbahnhof and only a 5-10 minute walk into the center city. The room, including the bathroom, was clean, and the bed was comfortable. My only complaint is that when I came home one night, I saw a drunk guy (presumably from the bar in the hostel) was peeing in the elevator. "
- 10 Aug 2014 Samantha USA
- " Definitely one of my favourite hostels! It's right across the street from the Hauptbahnhof, which is great after a long train ride. Plus, it's a 15-min walk to the heart of Munich: Marienplatz. The facilities are great: beautiful common area, individual reading lights and power outlets, laundry room and an amazing bar where you can easily meet other travelers. The price for breakfast is fair and the staff is really friendly and helpful. I'd definitely stay there again. "
- 09 Aug 2014 Luciana Brazil
- " Wifi and staff are both very poor. Two girls at staff kept chatting and making me wait and then acting very annoyed when they finally did address me. Very stuck up and set the tone for my stay. Mostly just a filing cabinet for travelers and not great for a solo traveller. Would not recommend. "
- 09 Aug 2014 Gregg USA
- " All staff were very friendly and helpful. The rooms were cozy, and the location is right by the central train station, making it very easy to find. Great stay! "
- 24 Jul 2014 Jake Canada
- " very good location, but the luggage room was totally full to use. Not me but my friend was bitten by bedbugs. Still be careful. "
- 18 Jul 2014 Anonymous South Korea
- " convenient lounge, nice staff, nice and spacious room. just one thing no kitchen.. except that everything is perfect. "
- 15 Jul 2014 Anonymous South Korea