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Scientific Agenda:
The Multiple Myeloma Genomics Initiative
Genomics is the study and interpretation of genomes, or gene sequences, and their function. When it became clear that recent technological advances would enable scientists to take an unprecedented look at the blueprint of multiple myeloma, the leadership at the Multiple Myeloma Research Foundation (MMRF) decided to launch a bold endeavor aimed at rapidly accelerating progress against myeloma through the decoding of its genome.
In April 2006, the Multiple Myeloma Genomics Initiative (MMGI) was initiated. The multi-million dollar MMGI program comprises several related research and discovery efforts spanning the spectrum of genomic science. Spearheaded by the MMRF and in partnership with world-class researchers from the Eli and Edythe L. Broad Institute and The Translational Genomics Research Institute (TGen), this cutting-edge research initiative is the most comprehensive research collaboration focused on the genomics of multiple myeloma. The MMGI was the first to decode the entire genome of patients' multiple myeloma tumor cells and in July 2009 announced that it had performed deep sequencing of three myeloma genomes. Moreover, the large number of myeloma genomes that will be surveyed through this effort is certain to have a dramatic impact on our understanding of the disease at the molecular level.
The MMGI's research and discovery programs hinge on the ability to study, analyze, and characterize a large number of myeloma patient tissue samples in great detail. This kind of research has been made possible only recently with the development of the MMRC Tissue Bank, a unique resource that houses high-quality bone marrow aspirates and matching peripheral blood samples accrued under Good Laboratory Practice (GLP) standards with corresponding clinical data. With over 4,000 patient tissue samples now accrued at the MMRC Tissue Bank and ongoing collection at sites in the US and Canada, researchers have access to the critical mass of tissue necessary to sustain this important genomic initiative.
Prior to the MMGI, there was no centralized repository of high-quality myeloma genomic data available to the scientific community to help generate critically needed new hypotheses. Also, interacting with genomic data is technically challenging, and remains a substantial barrier for data exploration and analysis. In response to these challenges, the Multiple Myeloma Genomics Portal was launched in 2007. The portal is the world's only myeloma-specific repository of genomic data and provides the scientific community with open access to high-resolution genomic data from the MMRC Multiple Myeloma Genomics Initiative pre-publication and in near real-time. In addition, data sets generated by other myelmoa genomics efforts are housed on the portal. A "workbench" of cutting-edge bioinformatics tools has been built into the MMGP to enable researchers to analyze and interpret the data. The portal now counts over 400 registered users.
New clues about the genetic determinants of multiple myeloma have started to emerge from the Genomics Initiative, but the work is not finished. In order to expand and translate these findings, a coordinated effort is required to study the functional consequences of the genomic alterations in cellular and animal models of the disease. In the future, the MMRF will support such studies so therapeutic agents that can potentially counteract the devastating effects of these genomic lesions are brought rapidly to patients whose myeloma cells carry such abnormalities. Only then will we be able to build on the foundation set for personalized medicine by the MMGI and provide to a myeloma patient the best possible treatment for his or her disease.


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LOUISVILLE, Ky. (WHAS11)—The former owner of the now closed Butchertown restaurant, The Blind Pig, has filed a lawsuit against his former landlord and business partner.
Joe Frase is accusing Peyton Ray of writing checks to himself, taking money from cash drawers and using a debit card for personal use during his management of a bar called Meat, which was located above the once popular restaurant.
The lawsuit claims Ray interfered with business operations and failed in his duties as the restaurant's partner.
When the case was last presented in court, a judge ruled in Ray's favor and said the restaurant should have been evicted because it owed nearly $37,000 in back rent, insurance and other fees.
Stay connected to WHAS11 for the latest in this developing story.

subset: commoncrawl


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KWillness: K.Will reveals his ideal type is Brown Eyed Girls' Ga In?
Singer K.Will revealed his ideal type is someone like Brown Eyed Girls' Ga In.
On the November 24th broadcast of MBC's 'Quiz to Change the World', the MCs brought up K.Will and Ga In's past connection when they appeared together on 'Infinite Challenge'.
Three years ago, K.Will…
♥ 김종국 ♥: Ailee on K.Will, "K.Will's attractive but he's not handsome", Kim Jong Kook disapproves
Singer Ailee spoke about K.Will's look.
On November 26th, cable channel Mnet's 'Beatles Code' featured guests Shin Hyo Bum, Kim Jong Kook, K.Will, and Ailee.
On the episode MC Tak Jae Hoon stated during K.Will's introduction, "He's not really an idol but he's not a veteran singer…
Daesung's long lost brother K.Will won!!


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Almond Joy candies take a swan dive into a rich chocolate batter to make these swoon-worthy afternoon treats. Pin this recipe for when you have leftover candy at the end of the month.
All You OCTOBER 2012
1. Preheat oven to 350ºF. Line an 8-inch baking pan with foil so it overhangs 2 sides by 1 inch. In a bowl, mix flour, baking powder and salt.
2. Melt butter and chocolate in a bowl set over a pan of simmering water, stirring occasionally. Remove bowl from heat; let cool slightly.
3. In a separate bowl, whisk sugar and eggs. Stir in chocolate mixture and vanilla, then flour mixture. Transfer batter to pan. Set Almond Joy bars on top, pressing lightly.
4. Bake until just set, about 35 minutes. Let cool completely on wire rack.
Go to full version of


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A magical outdoor activity for everyone
A perfect event for a family day out, the ideal special date venue, guaranteed a fun night out with friends
Tickets can be bought online, over the phone or at the box office.
1st November 2014 till 28th February 2015. The ice rink will be open everyday with the exception of Christmas Day.
If you would like to join the team, we would love to hear from you.
Send us your application.
Please complete an application form and email it to email@example.com and we will be in touch.
© 2012 - 2014 Ice Rink Canary Wharf. All rights reserved. Ice Rink Canary Wharf T/A - Registered company in England Reg. No: 8169969


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Hay Day Hack & Cheat Download
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The following set of pictures shown are from actual scenes along the Wisconsin River during the run of a fleet of lumber and a description of these rafts as they were built up is interesting. More so because the present generation has not no possibly ever will see anything like them.
Logs were cut in twelve, fourteen and sixteen feet in lengths. These were the
standard length of logs but special orders were complied with at the camps. The
raft was made by taking three planks and boring two inch auger holes about one
foot from each end and one in the middle. Into these holes, grub stakes were
inserted from underneath. These grubs, so called, were made from small trees of
about two inches in diameter and cut below the roots and trimmed to leave one
root branch at about right angles to the stem. Later in rafting, these grub
stakes were turned with a head to secure the pin from coming through the lumber
bottom plant when pressure was applied. After the grubs were fitted through the
planks, three other boards similar to the grub planks were set crosswise to the
bottom planks thus tying the form together making what later was called a crib.
Then the building of the crib began. The lumber to go into the raft was laid
cross wise and alternately until sixteen courses had been laid.
Binding planks parallel with the first planks underneath were fastened onto the grubs shown in the next illustration called "witching" or drawing tight the layers of lumber and fastening tight with a wedge run through the grub pin. This crib usually contained about four thousand feet of lumber. Six or seven of such cribs were fastened together tandem fashion, by coupling planks and this was called a "rapids piece", shown in the next illustration.
To make a firm setting for the head and tail block an eight inch square timber was fastened to the two end pieces. A head and tail block was put onto this square timber and fastened to the two end pieces. A head and tail block was put onto this square timber and very securely fastened. In the middle the head block was set an oar-pin to become a part of the steering oar. These oars were very large, the stems thirty feet long, one foot in diameter at one end and shaved down to about three inches at the other end. Into the large end of the stem was inserted the oar blade made of a blank set edge-wise, usually three inches thick and from sixteen to eighteen feet long. This made an oar fifty to forty-five feet in length. A hole having been bored in the stem the same size as the pin in the head block the oar was balanced on this pin. It required strength and skill to handle such a rigging. The man in front guided as he saw the current and the man at the tail also steered.
Two "rapids pieces" fastened together made a "Wisconsin Raft" and several such rafts comprised a "fleet of lumber", sometimes containing much as a million feet. To properly operate the "Wisconsin raft" it required at least ten bowsmen and ten tailsmen together with a pilot and steersman. When required all hands jumped into the water and with long heavy poles lifted the rafts off the sand bars. From Grand Rapids to St. Louis might require six weeks. On these rafts were built the cook's shanty and the "dog-houses" as sleeping cabins for the men. Number 4 shows these cabins and number 5 shows the cook's shanty.
When the rafts passed through towns where there was some population there were always a lot of young fellows waiting at the various eddies for a chance to run the rapids with the crew and when the water was not too dangerous this permission was granted, to the great delight of the boys.
The map is of the Wisconsin River with the particular rapids indicated by the names known in the "river" days.
Usually the ice went out of the river between the first and fifteenth of April and the log driving and running of the rafts began then or soon after though high water in June and September was better for running the river. The dangerous places on the river Big and Little Bull Falls, Stevens Point dam, Conant Rapids, Grand Rapids, Clinton's dam, Whitney Rapids, the Dells and Kilbourn dam. Mosinee - Little Bull - Rapids was the most dangerous on the river. Here, the channel narrowed to not more than thirty feet and the plunges "down a gulch" thirty feet deep, with a rock wall on either side. These rapids were a half mile long and one rebellious stream of water. All rafts were supplied with a "sucker line" which ran from one end of the raft to the other, for security of the raftsmen. Should a raft suddenly take a nose dive in the swift rapids it would take men overboard but for this line.
The dams were required to have log slides built in them at the natural course of the river. These slides were a part of the dam but the crest was at least two feet lower than the rest of the dam. The slides were provided with an apron built down stream and it was often a dangerous operation to guide a raft through these slides, for at the bottom it would duck under the water, and the men likely to be washed off but for the sucker-line. This apron often extended at the foot of the slide and was made of logs fastened at the slide with the lower end free to float. Grand Rapids was a rapids of importance to the drivers. There was about a mile of this water but with high water it did not take over five minutes to make the run.
Just below Grand Rapids was an eddy where the rafts tied up and the crew "gigged back" above the rapids to bring down another raft. This "gigging back" process was repeated after the raft had passed each swift rapid where only one piece could be brought down at a time. So the progress down the river until the crew reached Whitney Rapids was a succession of repeated miles.
Return to Lumber Rafting


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