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News from WTOP
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Mike Causey
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Shows & Panels
- The 2014 Big Picture on Cyber Security
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- Building the Hybrid Cloud
- CDWG/NetApp
- Connected Government: How to Build and Procure Network Services for the Future
- Continuing Diagnostics and Mitigation: Discussion of Progress and Next Steps
- Federal Executive Forum
- Federal Tech Talk
- The Future of Government Data Centers
- The Future of IT: How CIOs Can Enable the Service-Oriented Enterprise
- Government Perspectives on Mobility and the Cloud
- The Intersection: Where Technology Meets Transformation
- Maximizing ROI Through Data Center Consolidation
- Mitigating Insider Threats in Virtual & Cloud Environments
- Modern Mission Critical Series
- Moving to the Cloud. What's the best approach for me
- Navigating Tough Choices in Government Cloud Computing
- The New Generation of Database
- Reimagining the Next Generation of Government
- Satellite Communications: Acquiring SATCOM in Tight Times
- Targeting Advanced Threats: Proven Methods from Detection through Remediation
- Transformative Technology: Desktop Virtualization in Government
- The Truth About IT Opex and Software Defined Networking
- Value of Health IT
- Air Traffic Management Transformation Report
- Cloud First Report
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Shows & Panels
Mondays, 3 p.m.
Hosted by nationally-known speaker and consultant Mark Amtower, Amtower Off-Center highlights the good, the bad, the ugly and the just plain silly of doing business in the government market. Every week experts join Amtower for a lively discussion of current issues facing the government contractor community.
Talking BRAC
Raj Kuchadkar, Deputy Director of the Howard County BRAC Office and the Base Business Initiative (BBI) program joins host Mark Amtower to talk about the BBI program as it enters Phase 3.
October 31, 2011(Encore presentation November 7, 2011)
A tale of two (Maryland) schools
Host Mark Amtower is joined by Ellen Hemmerly, executive director of BWTech at the UMBC Research and Technology Park, and Capitol College President and CEO Mike Wood.
October 17, 2011(Encore presentation November 28, 2011)
Social media in the public sector
Market Connections President and CEO Lisa Dezzuti joins host Mark Amtower to talk about how government and contractors are using social media to do their jobs.
October 10, 2011
Building "Green"
Richard Knight, principal/vice-president of Aercrete Advantage LLC, joins host Mark Amtower to talk about the work being done by his company.
October 3, 2011
Fostering better communication between government and industry
Former "e-gov Czar" Mark Forman joins host Mark Amtower on today's program.
September 26, 2011
Acquisition reform and more
Allen Federal president Larry Allen joins host Mark Amtower to talk a wide range of government procurement issues.
September 19, 2011(Encore presentation October 24, 2011)
Events! nothing but events!
Federal Business Council COO David Powell and GovEvents president Kerry Rea join host Mark Amtower to talk about the importance of conferences, seminars and other events.
September 5, 2011
All things acquisition
Host Mark Amtower will talk government acquistion with Jaime Gracia, President and CEO of Seville Government Consulting, and Federal News Radio Executive Editor Jason Miller.
August 29, 2011(Encore presentation September 12, 2011)
Executive education programs at George Mason University
Nick Archer, director of George Mason University's executive education program, and Dr. Roy Hinton, the school's associate dean, join host Mark Amtower on today's show.
August 22, 2011
How to win business from the government
Author and consultant James "Jimmy" Baker joins host Mark Amtower to talk about what you can do to get government contract for your company.
August 8. 2011
An in depth look at the hottest government topics
Host Mark Amtower will talk debt crisis, cloud computing and other issues with Federal News Radio's Francis Rose.
July 25, 2011(Encore presentation August 15, 2011)
What 's next for federal contractors?
Allen Federal Business Partners CEO Larry Allen joins host Mark Amtower to talk about a variety of contracting issues.
July 18, 2011(Encore presentation August 1, 2011)
What 's ahead for federal contractors?
Host Mark Amtower is joined by contracting veteran Scott Friedlander, for a in-depth discussion of what you need to know, if you want to do business with the government.
June 27, 2011(Encore presentation July 11, 2011)
A looks at issues concerning small businesses
Scott Denniston, CEO of the Scott Group of Virginia joins host Mark Amtower for a discussion on issues concerning small businesses.
June 20, 2011
Helping small businesses get government contracts
Guy Timberlake, chief visionary officer of the American Small Business Coalition joins host Markt Amtower to talk about the organization, and how it helps companies that want to do business with the government.
May 30, 2011 (Encore presentation June 6, 2011)
An in-depth look at ACT-IAC
ACT-IAC Executive Director Ken Allen joins host Mark Amtower for a wide-ranging discussion of the myriad of projects that ACT-IAC is working on.
May 23, 2011 (Encore presentation June 13, 2011)
Women in technology
Women in Technology Communications Committee Chair Piper Conrad joins host Mark Amtower to talk about the group's mission and goals.
May 16, 2011(Encore presentation July 4, 2011)
What are the big cybersecurity issues?
Federal News Radio's Executive Editor Jason Miller joins host Mark Amtower for a wide-ranging discussion of how the nation's cybersecurity efforts have changed over the years.
May 2, 2011 (Encore presentation May 9, 2011)
What to look for when investing in a startup
Dendy Young, Managing Partner of McLean Capital, joins host Mark Amtower for a wide-ranging conversation on a number of contracting issues.
April 18, 2011
Amtower's brain trust discusses mergers, acquisitions,and more
Host Mark Amtower discusses a wide variety of issues with Washington Technology editor-in-chief Nick Wakeman and Lohfeld Consulting Group CEO Bob Lohfeld.
April 11, 2011 (Encore presentation April 25, 2011)


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Influenza pandemics HA Antibody have historically been linked to high levels of morbidity together with mortality. Pandemics return periodically and then a new pandemic is today overdue. The most serious pandemic threat in recent times has been posed through the highly pathogenic avian influenza virus H5N1 Anti-HA Antibodies which emerged in South-East Parts of asia in 1997. Cumulatively 385 cases have been reported with an general mortality of 63%. In addition other avian influenza worms including H2, H6, H7 and H9 subtypes are reported to either get caused human cases or shown potential to take some action, and are also recognised as probable pandemic threats.
Readiness to confront an influenza pandemic is still a major public ailment. Broad spectrum antivirals, such as the neuraminidase inhibitor oseltamivir, HA Antibody have been stockpiled as a first line defence against immediately spreading HPAI strains. However the utilization of oseltamivir in the treatment of H5N1 infections has been associated with the generation of resistant viruses in addition to a sharp increase in that isolation of human H1N1 stresses resistant to oseltamivir was recorded in 2008 providing that other preventative measures are required. Pre-pandemic vaccination has been put forward as something to ameliorate the spread of virus and brutality of disease, however all vaccines enjoy the limitation that they safeguard at best against strains in the same subtype. Consequently, an immunological intervention which is to be active across the selection of potential pandemic subtypes together with clades remains an elusive goal for influenza prophylaxis together with therapy.
Passive immunization has been anecdotally reported to work against H1N1 and H5N1 worms indicating that immunoglobulins may be effective against infection and disease with the systemic nature seen in the H1N1 1918 influenza outbreak. Influenced by this, broadly cross-neutralizing monoclonal antibodies with avian influenza virus H5N1 have been completely pursued using a variety of approaches. These kind of approaches have concentrated with using convalescent patient material as a source of B cells for screening of antibodies. However it is definitely known that the protected response against influenza viral is highly restricted, as borne out by a recent cloning study , HA Antibodies and centered on subtype and strain specific epitopes. Thus to reach a more diverse immune repertoire we find the novel strategy of interrogating this human IgM+ memory N cell repertoire. Nevertheless this subset of M cells is characterised by CD27 expression and mutated / genes, both tightly from the memory B cell phenotype, the foundation and role of this subset of B cells is controversial. It has been proposed that circulating B cells with this particular phenotype are linked to marginal zone B cells and have a primary role with T independent immunity when argue they are formed included in an intermediate differentiation help normal T dependent germinal centre immune responses. A few reports have highlighted a job for IgM in earlier stages of protection with experimental influenza virus test. Intriguingly the following protective role includes influenza viral subtypes to which mice are immunologically.
In this study we have built combinatorial libraries and selected a panel of people monoclonal antibodies against H5 HA from your particular compartment of memory B cells which were characterized by their ongoing expression of IgM at first glance. Our results suggest that IgM+ memory B skin cells express mAbs recognizing T-dependent antigens with high affinity, and consistent with a hallmark of recollection B cells, all selected H5N1 mAbs included mutated VH genes. Memory B cells are generally defined by their rapid proliferation and difference into antibody secreting plasma cells on re-exposure to antigen. Yet from this study not necessarily clear that the IgM+ random access memory B cells expressing your cross-neutralizing HA specificities participate in a true recall answer upon vaccination. A small increase in serum neutralizing activity was measured in all vaccinated donors for H1N1 and not H5N1, Anti-HA Antibody even in donor from which the heterosubtypic neutralizing mAbs have been isolated. Thus if the B cell clones expressing CR6261 along with the other cross-reactive mAbs were present in the donor prior to vaccination (as may be expected) then an honest recall response associated with differentiation into plasma cells haven't likely occurred. Although we could not exclude the chance that at later time points serological differences might have been measured the results are consistent with the observation that measurable heterosubtypic immunity is rare in the general population.
We have not made a comparative analysis of other B cell compartments to look into whether related clones can be found in isotype switched memory cells or plasma cells of donor or even other donors. However, preliminary data for a mAb isolated from the bone marrow of an H5N1 Anti-HA infected patient has been recently reported that boasts cross-neutralizing activity between H5N1 and H1N1. Extremely this mAb uses the IGHV1-69 germline gene together with conserves the hydrophobic residues in the tip of the HCDR2 loop that him and i show in this study to remain critical in binding your conserved hydrophobic pocket with HA. Sorry to say without further data it may only be inferred that mAb is binding to the same region as CR6261 and also other mAbs described in this study. The ease at which the IgM+ memory B cell repertoire may be accessed in normal, corrupted and vaccinated donors in comparison to bone marrow and the diversity in such a repertoire compared to antibody secreting cells supports this process to generate therapeutic mAbs with other pathogenic targets and really should be further explored.
Other articles you might like;

subset: commoncrawl


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See and share Beautiful Nature Photos and amazing photos of interesting places
Roque Vallejos Biography and Poems. This is biographical information on Roque Vallejos, one of the best poets of all time. This biography page also provides a link to poems written by Vallejos, as well as, a video biography...if available.
Roque Vallejos (Asunción 1943 - Asunción, 2 April 2006) was a poet, psychiatrist and essayist from Paraguay .
More Roque Vallejos Information


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Yahoo! Toolbar - Internet Explorer
- Category: Browsers
- Operating Systems: Windows
- File size: 227.25 Kb
- Number of downloads: 357
- Latest version: 184.108.40.206
- License type: Freeware
- Developed by: Yahoo! Toolbar - Internet Explorer
- Latest update: 06-12-2010
Authors (3/5)
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Yahoo! Toolbar - Internet Explorer
Yahoo! Toolbar - Internet Explorer is an impressive tool that helps you search the Web from anywhere in the world. You will be amazed at how easily it discovers and adds RSS feeds to My Yahoo! and how you can customize and access your toolbar from any PC.
Yahoo! Toolbar for Internet Explorer gives you the assurance of a hassle-free surfing, because it has a Pop-up Blocker and Anti-Spy features for your security and peace of mind. You may enter the Yahoo! Email and Yahoo! Messenger without being bothered by pop-ups.
Yahoo! Toolbar is a freeware packed with the essentials such as a search box, a popup blocker, bookmark support, spyware removal and an award-winning Anti-spy technology. It can work with Win 98 and 2000 OS.


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Latest headlines
- Top 5 Reasons to Participate in the Mammoth Winter BiathlonI recently competed in my first winter biathlon, and while I did not ski fast or shoot straight,... Continue
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Welcome to Hotel Srinivas
Located on M.G.Road, the heart of Cochin, Hotel Srinivas is close to the city's most prominent shopping areas, Marine drive, Bus stations, Parks, Places of worship, Banks, Commercial areas and is very near to Ernakulam Town, Ernakulam Junction Railway stations.
With 48 spacious,elegantly furnished and well maintained A/c and Non-A/c rooms, Hotel Srinivas has amenities which includes direct dial telephones and a lot more. Facilities include Car Parking, Cable TV, Room service and a well furnished restaurant with vegetarian cuisines.
|Holiday home for State Bank of Bikaner & Jaipur


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I was tagged by vanelandia
1.-What's your favorite food?
potatoes or empanadas :D
2.-What's your first language?
3.-What's your age?
19 years DD:
4.-Are you studying? if your answer is yes, what are you studying?
5.-What are your biggest flaws?
trust to much in the people
6.-Do you believe in love at first sight?
maybe haha
7.-What kind of books do you like?
drama, romantic and erotic paranormal :)
8.-What is your favorite book?
omg this question it's so dificult because i have a lot of favorite books
9.- If I could offer you anything in the world, what thing would you want?
uff… i don't know
10.-What part of your body do you like the most?
my eyes i think
11.-If these things were in your power: Peace for the world, food for the hungry, love for they who needed it, what would you choose to give away and why?
love, because i think that the people need more love in their lifes
My questions
My questions


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Goddard College BFAW student Jason Stocks reads his poetry
Goddard College BFAW student Jason Stocks reads his poetry
Goddard Videos
Goddard College student Jason Stocks speaks about his Goddard experience in and reads three of his poems.
Goddard Videos
Watch More Goddard Videos
Executive Chef Paul Somerset talks about the food program at Goddard's Vermont campus. The Vermont campus serves 100% local meat and is moving toward more locally produced goods. Goddard College... more
BA in Sustainability, About Goddard
Watch students from across the country as they talk about their experiences at Goddard College. If your life was transformed by Goddard, please consider giving to our... more
Individualized Bachelor of Arts
Individualized Bachelor of Arts
BFA in Creative Writing


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Crisis Intervention in Criminal Justice/SocialCharles C Thomas 2014; US$ 59.95
This expanded new edition continues to demonstrate and provide theoretical, analytical, and practical knowledge for first responders. Face-to-face interaction with the client/victim is part of the comprehensive approach advocated by the book, which requires interveners to assess the nature of a crisis and the condition of the victim in order to determine... more...
Crisis InterventionCharles C Thomas 2010; US$ 49.95
Criminal justice professionals are confronted with crisis situations on a daily basis in an era when crime ranks in the forefront of domestic social issues, and the administration of criminal justice is a major concern of public officials and the public. This expanded new edition delves into the historical perspective of crisis intervention and examines... more...
Multicultural Perspectives in Criminal Justice and CriminologyCharles C Thomas 2000; US$ 36.95
This second edition of Multicultural Perspectives in Criminal Justice and Criminology addresses cultural diversity, criminal justice, and criminology. As an edited anthology, this book represents the work of national scholars who have expertise in criminal justice issues and multicultural contexts. It includes original work addressing such diversity... more...
Multicultural Perspectives in Criminal Justice and CriminologyCharles C Thomas 2011; US$ 36.95
This third edition of MULTICULTURAL PERSPECTIVES IN CRIMINAL JUSTICE AND CRIMINOLOGY has been slimmed down from previous editions. Chapters have been combined and subjects updated throughout. In keeping with the theme of previous editions, this third edition addresses cultural diversity, criminal justice, and criminology. As an edited anthology, this... more...
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By Len Kiese - bio | email
ALBANY, GA (WALB) – An Albany church is preparing for an annual food giveaway. They expect one of the biggest turnouts ever.
Last year dozens lined up for a crowded giveaway at First Apostolic Church. Wednesday night, members started bagging items for this weekend's event.
They'll give away turkeys, hams, hens and other items to families in need. Pastor Betty Jackson says people usually start lining up at 4 a.m. and she expects to see more in line this year.
"Of course we expect to see more people this year because of all the many layoffs in Albany, Georgia," said Jackson, "and what we are trying to do this year is ensure that the city of Albany and surrounding counties receive help."
The giveaway will begin at 8 Saturday morning at First Apostolic Church on Lumpkin Street.
Jackson says they wouldn't be able to do so much without contributions from the community and church members. They could always use more as they expect to serve 1,200 people this year. To help, call 229-869-1549.
©2009 WALB News. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. Feedback
P.O. Box 3130
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(229) 446-1010
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A look at the rollercoaster year of Nuggets basketball
Hopes were high for the Nuggets at the end of the 2012 offseason, with some analysts predicting up to 59 wins and a top two playoff seed. Masai Ujiri had acquired Olympic gold medalist and star defender Andre Iguodala in a trade, and extended Ty Lawson and JaVale McGee with long-term contracts. He surrounded the team's young core with veteran Andre Miller and cheap talent like Anthony Randolph and Evan Fournier.
But a difficult early schedule loomed. The Nuggets would play 22 of their first 32 games on the road, including 8 sets of back-to-back games. By the end of November, the team had a pair of four game winning streaks sandwiched in between three losing streaks of three games each, including worrying losses to the lowly Suns and Magic.
If you've been following the rumor mill lately, you're probably aware of the frenzy that a potential blockbuster trade between the Boston Celtics and the Los Angeles Clippers has caused, momentarily even overshadowing the NBA Finals. But before Boston and LA engaged in negotiations, Josh Kroenke made a call the Celtics, offering a first-round pick for the release of Doc Rivers.
A little over two months ago I posted a video piece on Andre Miller's clutch play that helped seal Denver's victory against the Indiana Pacers on Dec. 7. With eight points and an assist in just 104 seconds, Miller poured it on in crunch time to lead the Nuggets to a big road win at a time when they were struggling.
Unfortunately, we are back in the Film Room today to visit what essentially was the opposite scenario. In their heartbreaking road loss to the Celtics on Feb. 10, the Nuggets were down just two points with 48 seconds remaining in the game's third overtime when Miller retrieved the rebound off a missed Kevin Garnett jumper. And as every Nuggets fan not living under a rock is well aware, from there the train rapidly derailed from the tracks.
The Film Room video, followed by analysis of Miller's play and George Karl's coaching, is after the jump.
St. Patrick's Day, March 17, 2012. The Boston Celtics at the Pepsi Center in Denver (with all too many traitorous green jerseys in attendance). The only matchup between the Nuggets and C's in the lockout shortened season. And Denver jockeying for playoff positioning as the season drew closer to an end.
It was a huge game for the Nuggets. And despite the hype surrounding the St. Patty's-Boston imagery, the most important symbolism of the game was when George Karl uncharacteristically entrusted a rookie, Kenneth Faried, to close out the final minutes of a closely contested contest.
And the Manimal delivered. Scoring 18 points on perfect shooting, including five of five from the field and eight of eight from the line, Faried also grabbed 16 rebounds — 6 offensive — with a steal and a block on top. Beyond the stat line, he was the engine that fueled the team's energy and drive with infectious, relentless effort. And he played a crucial role in earning the Nuggets victory.
|Kenneth Faried, F 24 MIN | 5-5 FG | 8-8 FT | 16 REB | 1 AST | 18 PTS | +9
By halftime, Faried had 11 rebounds while the entire dead-legged Celtics team had 12. He turned in a career night in only 24 minutes, which would have been about 17 had Miller and Harrington not engineered an epic fourth quarter collapse. He was the most dominant player on the floor and he's doing it all without the support and trust of his head coach. This guy just doesn't know to quit. Nothing stops him.
|Danilo Gallinari, SF 32 MIN | 5-11 FG | 7-8 FT | 5 REB | 3 AST | 20 PTS | +10
Why he got only one shot in the fourth quarter is a mystery, but all things considered this was another solid effort by Gallo on both ends of the floor. He was looking to wear down the Celtics early and none of the men in green were able to stay in front of him. Gallo's aggression set the tone early and his shot selection was simply outstanding. Gallo's a much smarter player than people give him credit for.
|Timofey Mozgov, C 19 MIN | 4-6 FG | 0-0 FT | 4 REB | 1 AST | 8 PTS | +4
Since returning from injury, Mozgov's been playing his ugliest ball of the season. It was great to see him bounce back with a focused effort against a team like the Celtics, who are not the championship contenders they once were but still have one of the league's top defenses. He appears to be getting some of his elevation back and looked much more confident on the offensive end.
|Arron Afflalo, SG 30 MIN | 6-14 FG | 2-3 FT | 1 REB | 4 AST | 15 PTS | +10
Afflalo was somehow very erratic and steady at the same time. He took 14 shots and missed some easy interior passes by not realizing when his 7-foot teammates were posting up guards. Yet he still led the team with a +10 in 30 minutes and ended up with the second most assists behind Lawson. He played well, but from a leadership standpoint I think he can still improve quite a bit.
|Ty Lawson, PG 35 MIN | 2-5 FG | 2-2 FT | 5 REB | 10 AST | 7 PTS | +7
It was a very rough game for Lawson, who often had to guard Allen and Rondo while Andre Miller took the night off. He took five shots in 32 minutes, which is just way too passive even though he realized the Nuggets needed to be going through their bigs, who were wearing the Celtics down. Lawson's heads up play and staunch defense rescued Denver's guard play from the terror of Andre Miller.
|Al Harrington, PF 28 MIN | 4-12 FG | 2-4 FT | 4 REB | 1 AST | 11 PTS | -1
For every good play Al Harrington made there was a boneheaded mistake. That kind of inconsistency can't be afforded with Al anymore. With Nene out of the picture, he seems to know he's got tons of freedom and total immunity from the coaching staff. That's all fine and well so long as Harrington plays unselfishly and makes smart decisions. Al's blooper reel included an uncontested three-point airball that missed the rim by about five feet. I'm serious
|Andre Miller, PG 23 MIN | 1-8 FG | 0-1 FT | 2 REB | 2 AST | 2 PTS | -2
He clearly doesn't care anymore, and neither do I. Miller gets no more words out of me. Scroll down to the comments if you really wanna know how bad it was. Our informed readers can get this one for me. I'm done with Andre Miller.
|Corey Brewer, SF 17 MIN | 3-5 FG | 2-4 FT | 0 REB | 1 AST | 8 PTS | -4
Brew's hands were all over the court. He hounded Rajon Rondo, whose eye popping production didn't come without some serious pressure during Corey's limited time on the floor. He is so adept at stealing the ball and really makes that over-aggressive style work for him.
|Rudy Fernandez, SG 18 MIN | 1-3 FG | 0-0 FT | 2 REB | 3 AST | 3 PTS | -7
Rudy is making steady progress since his return to the bench rotation, but I'd place him in the Al Harrington category as a little too spastic in this particular game. I don't want to judge Rudy too harshly because he was forced to play nearly all of his minutes alongside Andre Miller.
|Kosta Koufos, C 15 MIN | 3-5 FG | 0-1 FT | 7 REB | 0 AST | 6 PTS | +9
Koufos had perhaps the perfect performance for a defensive backup Center. When you look at his numbers and the appropriate 15 minutes of playing time, you see a guy who knows exactly where he fits into the puzzle. On a night the bench just wasn't getting it done, Kosta stepped up big.
This post is a compilation of analysis and breakdown of 2012 schedule in the hours after it was released. To view the official schedule visit the Nuggets website at NBA.com. If you prefer a printable version of the schedule to reference click here for a link to the PDF. Scroll down to read updates and new developments on all things schedule related.
How do you build a championship roster?
That is a question that General Managers and Presidents of Player Personnel must ask themselves every day. What complicates things is while every team starts every season at 0-0 not every team is created equal. What works in one market is not feasible in another. Add in the fact that no two teams are at the same point in their process of building a team and the possibilities for every team are endless. Every decision creates a ripple in the pool of NBA chaos.
With the NBA Draft now less than a week away, it's time Roundball Mining Co. unveils it's top ten prospects, ranked in order, from the one guy fans should be dying to get, to just a flat-out solid prospect. Factors included in determining the player-rankings were mostly size, potential, athleticism and overall skill level. Keep in mind, all the players codified in this post are ones that will likely be available when the Nuggets select at No. 22. You won't find Bismack Biyombo on this list, because 21 NBA teams are smarter than to pass up on a guy that talented, even if he is 24-years-old. So, without further ado, I give you the official Denver Nuggets Big Board 2.0! (more…)
When I sat down tonight to watch the Denver Nuggets take on the Charlotte Bobcats, I certainly did not expect to see the Nuggets pull off the fifth biggest margin of victory in franchise history. But… THAT JUST HAPPENED! (more…)
There was confusion, miscommunication, a few quizzical glances and some ugly shooting. There was also effort, passion and a Nuggets team who clearly cared more about winning than anything else. For years the Nuggets have been all about whether their talent can outweigh that of the opposition. Now after two games without an All-Star on the roster Denver does not lack talent, but we may be seeing a situation where the whole is greater than the sum of the parts.
ESPN.com recently ran a feature where Chad Ford and John Hollinger ranked the potential for future success of all 30 NBA teams (Insider required). Every team was ranked based on five important characteristics, players (weighted 40%), management (weighted 20%), money (weighted 20%), market (weighted 10%), and draft (weighted 10%).
As a Nuggets fan and observer I believe they forgot one very crucial category, luck.
Whether you call it luck or intangibles, mojo or fortune it comes down to the fact some teams seem to have things go their way a little more often than others. Look at the teams that have dominated the NBA over the previous two decades. Chicago, San Antonio, Los Angeles and Boston had at least one tremendously lucky break that has paved the way for their success.
Box Score | Highlights | ESPN360.com Replay
I am done pulling my punches with this team. All year long I have proclaimed them the second best team in the west. Defended their softer defense and looked the other way with their bad habits. Now that they are shorthanded on the court and on the bench all of the little things they have failed to do all season long are catching up to them. The result is a three game losing streak and what appears to be the beginning of a downward spiral that is threatening their season.
What I really wanted to do with this post is list all the lazy defensive plays the Nuggets made in the fourth quarter alone, but I rarely trust my instincts. Then I remembered that the opposite of my instincts are usually wrong too so here we go.
11:30 – Carmelo jogs back on defense and thus was not in position to defend the pass to Tony Allen after Ty Lawson stopped the ball.
10:49 – J.R. Smith allows Allen to step inside of him on a shot giving up his position for the defensive rebound. The ball came off to the other side and because Smith was not in the lane Rondo was able to collect the ball and then score on the other side of the rim because J.R. was not where he should have been.
9:19 – Rajon Rondo begins a left handed drive from five feet beyond the three point line. He gets Chauncey, who was playing several feet off of Rondo to defend against the drive, on his hip at the free throw line. Carmelo Anthony who is actually under the basket at the time has no idea Rondo is coming because he is walking along side Pierce as he moves from the right side of the lane to the left with his back to the ball. Melo was under no physical or mental duress to prevent him from seeing the ball and staying with Pierce at the same time. It was a simply unconscionable non play.
8:53 – Paul Pierce brings the ball up the floor at a trot. Carmelo for some reason has decided to go over to Rondo even though Chauncey is close by and Pierce is Melo's man. After an attempt to communicate and get back to covering their assigned man neither one covers Pierce who drives from half court to the rim for a layup. Nene did slide over to help, but instead of being ready to make a play on the shot simply stood still allowing Pierce to easily glide past him for the layup.
8:15 – A solid defensive possession where Nene hedged on the screen, Chauncey recovered and Lawson sunk into the lane to cover Garnett on the roll until Nene could recover leads to a travel. It really is not that difficult to defend a screen and roll.
6:48 – Pierce drives away from a screen and gets past Joey Graham. J.R. Smith makes a half hearted swipe at the ball, but honestly with the assignment of covering Ray Allen it is best that he stays home. Carmelo, covering the much less dangerous Tony Allen who is in the offside corner, barely budges and never comes over to help on the penetration by Pierce. Result a three point play
6:06 – Despite the fact he has about eight feet between he and Rondo Chauncey lays back and runs into a screen instead of moving one foot closer to his man and stepping over the pick. After Chauncey gets taken out, Melo shoves Rondo for a foul despite the fact he had done a half way decent job of keeping Rondo from turning the corner coming off the screen.
5:55 – Later that same possession after J.R. and Nene do a decent job trapping Ray Allen on a pick and roll no one steps over to help cover KG on the roll. Garnett catches a pass from Allen just above the block with no Nugget within five feet of him. Graham rotates over late and flies in front of Garnett who blows the easy layup. Once again Carmelo paid tribute to ancient Greece by impersonating an ancient ruin as he stood motionless on the weak side block.
4:59 – On a shot by Pierce Carmelo stood watching the ball as Tony Allen moved past him into the middle of the lane and Rondo cut past him along the baseline both in position to nab an offensive rebound. The ball caromed off the back iron flying well over all of their heads and Melo's laziness goes unpunished.
4:35 – After a make by Graham Rondo is walking the ball up the floor. J.R. is walking near Tony Allen. The problem is he is supposed to be guarding Ray Allen who is wide open in the corner. The pathetic thing is Smith realizes his mental error, but instead of hustling to where Ray Allen is and possibly drawing attention to his mistake he shuffles slowly as if he has nowhere in particular to be. Rondo finally notices Ray and passes the ball. Smith is completely out of position and has no chance to cut off the baseline drive. Nene saves a basket by blocking the layup attempt. On the weak side Melo looks on. Joey Graham, who was coming over to do what he could kept Tony Allen, Melo's man from getting the loose ball and getting a layup. Still the ball goes off of Graham and Boston retains possession.
4:26 – After having success with hedge and recover and trapping schemes on the pick and roll Denver is back to switching. Carmelo is brushed off of Pierce about 30 feet from the rim and decides to sling back into the lane covering no one in particular. Meanwhile Nene and Afflalo double KG on the block after Arron switched over to Garnett on a screen. Kevin passes to Ray Allen in the corner and Chauncey leaves Rondo to run at Allen. Melo had three choices. One, he could look for Chauncey's man, Rondo who was the leading rebounder in the entire game, and get in front of him as he crashes the offensive boards. Two, he could go box out Tony Allen who is alone in the middle of the lane. Three, he could stand still. Melo chose to stand still and Rondo swept in for the rebound.
3:56 – Carmelo is playing Tony Allen to drive as he is a good seven feet off of him. Allen still chooses to drive and blows by Carmelo who was practically standing straight up instead of crouched and ready to defend. Afflalo rotates late and fouls Allen at the rim.
3:15 – Nene and Afflalo trap Ray Allen on the left wing after a screen by KG. Chauncey is at the top of the circle and when KG gets the pass back from Allen Chauncey plays him to swing the ball instead of getting in front of him and closing a wide open lane to the rim. This time Melo does come over to help, but only to take a weak swipe over his head at the ball. Nene recovers to challenge KG at the rim and forces a miss. J.R. Smith plays the role of statue on this play as he allows Tony Allen to run from the corner all the way along the baseline to tip the rebound to Rondo who passes to KG for an open layup.
2:37 – Chauncey and Nene trap Rondo after a screen by Garnett. The Big Ticket rolls into the lane while Carmelo inexplicably waits too long to react to the play. Melo must not realize that you can be in the lane, just not for three consecutive seconds. There is no reason he was not planted and ready to prevent KG from being wide open. Melo does foul Garnett which I guess counts as a moral victory.
1:57 – Rondo drives the left side of the lane and dumps the ball to Garnett. Tony Allen dives into the lane completely unnoticed by Melo. By the time Garnett shoots Allen is back outside the lane, but he runs right around Melo who is this time impersonating an individual viewing a solar eclipse with the ball filling the role of the sun. Allen gets the rebound in front of Carmelo and extends the possession. Ray Allen hits a three to put the Celtics up 15.
I think you get the idea. The really sad thing is that was probably the best quarter the Nuggets played defensively. It did not include the offensive rebounds off of free throws or instances where Denver was leaving the entire lane wide open.
It goes to show how one player can ruin a defensive possession. All too often that player is Carmelo. He showed some real moxie early in the season on defense and I praised him for his willingness to cover LeBron during their win in Cleveland. Right now he is playing some of the worst defense of his career and it is inexcusable.
The one thing that stood out to me in going over the film again was how hard Nene played. He did a great job of making it difficult for the Celtics bigs to set their screens and he prevented the ball handler from turning the corner and getting in the lane. Arron Afflao worked very hard too and kept the mental mistakes to a minimum.
The bottom line is Denver is in danger of falling into fifth in the West by the end of this road trip. If the coaching staff does not alter their tactics and get away from switching screens and the players do not begin to play with focus and attention to detail they are going to dig themselves a very dangerous hole.
Additional Game 72 Nuggets
Ty Lawson finally saw some game action and his presence provided a visible, albeit short lived, boost of energy and confidence. The players know who should be playing and who should not. From the day he stepped foot in Denver Lawson's teammates talked about how good he was and how he should be on the court. It had to have been a little demoralizing to see Anthony Carter constantly enter the game when Lawson was physically able to play. Now the bad news, Lawson was not very good. Following a very good initial possession on defense where he fought over the screen and along with a strong hedge by Birdman forced Nate Robinson to turn the ball over resulting in a dunk for J.R. Smith Ty looked very rusty and turned the ball over three times, all of which were absolutely horrid passes. Still, Lawson got in the game and the derustification has begun.
J.R. played a very good game on offense. He only took three three pointers which is much better than seven or nine and two of those three came at the end of quarters. His lone make came at the end of the third as he caught a perfect pass from Chris Andersen as he ran a streak pattern up the left sideline, a play that showed great presence of mind by Birdman. J.R. took a rhythm dribble to gather himself and hit a big shot that narrowed the lead down to seven.
The Celtics crushed the Nuggets on the offensive boards. According to ESPN Stats and Information Boston entered the game 28th in the league in offensive rebound rate, but that did not stop them from posting an offensive rebound rate near 38%. Their 90 shot attempts was a season high.
Advanced Game Stats
Pace Factor: 91.5
Defensive Efficiency: 123.3 – embarrassing
Offensive Efficiency: 108.2 – below average, but short of embarrassing
Featured Blogs: Celtics Hub | Celtics Blog
The contrast between the Boston Celtics and the Denver Nuggets in the 114-76 demolition last night was quite startling. One of the biggest gaps between the two squads was how they defended screens. The Nuggets continue to rely too heavily on switching while the Celtics help and recover as well as anyone in the NBA.
I have put together several clips that display very clearly the hedge, help and recover system the Celtics use on pick and rolls and the switch and pray system the Nuggets are so fond of.
Keep in mind the Celtics played defense like this without Kevin Garnett who is a vital defensive cog in their system. Had KG been on the court it is possible the Nuggets would not have broken 60.
The point is as long as the Nuggets defend screens like this, regardless of the opponent, they will be lit up more often than not. Switching does rarely work as it did against Orlando and Philly, but against most teams it is like asking Stephon Marbury to show the new female intern his truck.
Check out all my videos in the Film Room
The Nuggets seem to think that they have arrived and should be in the mix for the coveted veterans who are bought out and/or released by the terrible teams that they are playing for. So far there are two players who might fit that mold, Sam Cassell and Mikki Moore although neither is worth much on the court.
George Karl has spoken about his desire to bring in his old buddy Cassell to add all of those special things that veterans can add. Apparently the special veteran point guard/coach on the floor/championship experience Chauncey brought to Denver is wearing off. More importantly with Nene and Kenyon Martin having missed games in the last couple of days the search for additional big man insurance, apparently the safety blanket that is Johan Petro is not keeping the nightmares away, and Denver was hot and heavy after Moore. Surprise, surprise, despite the Nuggets best efforts, Moore signed with the Boston Celtics.
The other big man that all the contenders are panting over is Oklahoma City's Joe Smith. Of course Denver is interested in him too. In the effort to save the Nuggets' front office a lot of work and disappointment I have crafted the following note:
There is a good chance that the Thunder will release Joe Smith and you will envision how much high quality veteran-ness he can bring to the Nuggets. Treat the potential addition of Smith to the Nuggets roster as a fleeting thought like eating your weight in Thin Mint cookies or pushing the person next to you onto the light rail tracks right before a train approaches. No good will come of your efforts. Smith's agent will take your call and make you feel warm and fuzzy, but there will not be a second where he will consider joining the Nuggets.
Denver is not on the same level as true contenders such as Cleveland, Orlando, Los Angeles (not the Clippers), San Antonio, Boston or even New Orleans. Do not take solace in the fact the Celtics have signed Mikki Moore. Even though that is one fewer team you must compete with it will not change a thing. As long as any of the previously mentioned teams have interest in a player, he is not coming to Denver.
Approaching Smith's agent will only serve to remind you, and us, that Denver is still not considered an elite team, nor is it an elite destination. Whatever time you put into the pursuit of Smith, or any other quasi-useful veteran player will be time that could have been better utilized doing something else. You might as well try finding a cure for cancer because as unlikely as it is that you might be successful the chances are better than the 0.000% chance you persuade a waived veteran whose play is worth the contract he signs to join the Nuggets.
I hope you find this advice helpful, but more than that I hope you follow said advice.
P.S. Sam Cassell will probably sign with you should you make the inane decision to offer him a contract. Do not let that go to your head.
Nene out one or two weeks
As expected it was determined that Nene did not have any structural damage to his knee. Unfortunately, the bruise is bad enough that he might miss up to two weeks (see link above). Considering the Nuggets Pythagorean projected record is 3-79 without Nene in the lineup this season missing him for two weeks, with Portland and Utah breathing down our necks is not something I want to think about.
Let's move on.
Hurricane Rondo
I certainly did not give Rajon Rondo enough credit for his play last night. He is quickly developing into a player who can do whatever he wants on the floor. He has tremendous instincts, a great handle, superlative vision and has a mean streak. He is afraid of no one and did not think twice about challenging Chris Andersen for rebounds or attacking Birdman off the dribble. Rondo is quickly making a name for himself and has been endorsed by TrueHoop contributor Kevin Arnovitz and Henry Abbott's mother.
When rough is not tough
Another thing I forgot to mention in my game recap for the blowout to the Celtics was how after already having been manhandled by the Celtics the Nuggets tried to get physical. Kenyon was called, and I think rightly so, for a flagrant one on the shot he gave Ray Allen and Anthony Carter ran through Allen on a three point attempt late in the third quarter. Maybe both Nuggets felt like they sent a message and felt like they had exhibited toughness.
To me the player who exhibited true toughness was Ray Allen who after getting knocked off the court by Martin made both free throws (the start of what ended up being a five point possession) and on the play he was drilled by Carter he made the three and the free throw.
Sports movie Oscars
Denver Post Nuggets beat writer Benjamin Hochman put together a great post on his personal list of nominees and winners for the all time sports movie Oscars.
There were three simple differences between the Boston Celtics and Denver Nuggets tonight.
One team was the Celtics and they won by 38. The other team was the Nuggets and they lost by 38.
Playing hard for 48 minutes is a cliché. Every team has slumps of a few minutes here and there where the effort wanes and they get lazy. I promise you the Celtics played their bums off for all 48 minutes. The collective competitive spirit puts the Nuggets to shame. Kendrick Perkins was bickering with the refs with about a minute left after he was called for traveling. These guys do not care what the score is. The score is almost immaterial. They are giving it their all from start to finish.
For the Nuggets the built in excuse is that they have been on a three week long road trip and it was unfair to ask them to play the Celtics a day after they played in Milwaukee. I am not buying it. As has been pointed out by many people, including myself, the road trip they just finished was only a three game trip. Sure they played five road games in a row before that, but they had six whole days off during the All-Star break. The Celtics were the team that had to check into hotels last night after playing in Phoenix.
Honestly it did not matter who suited up, how many days in a row the Nuggets had played or what strategy the coaches asked the players to implement. Boston played with confidence and determination while the Nuggets looked like a scrawny book worm getting ready to ask out the prom queen.
Denver has now lost by 40 points, give or take a couple of points, twice in their last seven games. Does that scream contender? The game in New Jersey could be written off as a fluke, but for it to happen again just seven games later is shocking. I guarantee you the Trail Blazers and Jazz are licking their chops right now.
Denver now has a day off to prepare for an Atlanta Hawks team that was blown out by the Jazz and two days later the Lakers roll into town. They better get their act together by Wednesday or else they will be going back out on the road with a five game losing streak.
Additional Game 57 Nuggets
Mindboggling Game Stats
Pace Factor: 89.5
Defensive Efficiency: 127.4 – Fourth worst single game rating this season.
Offensive Efficiency: 84.9 – Second lowest single game rating this season ahead of only the 44 point drubbing in New Jersey.
Featured Blogs: Celtics Hub | Celtics Blog


text:
Research Topics
Genomes and Genes
Gene Symbol: CD9
Description: CD9 molecule
Alias: BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29, 5H9 antigen, BA-2/p24 antigen, CD9 antigen, CD9 antigen (p24), cell growth-inhibiting gene 2 protein, leukocyte antigen MIC3, motility related protein-1, tetraspanin-29
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications235 found, 100 shown here
- Effects of K+ channel blockers on the action potential of hypoxic rabbit myocardiumE Ruiz Petrich
Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke, , Canada
Br J Pharmacol 106:924-30. 1992..and at least one yet unidentified current component rather insensitive to changes in [K]o and to K+ channel blockers...
- Complexes of tetraspanins with integrins: more than meets the eyeF Berditchevski
CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
J Cell Sci 114:4143-51. 2001....
- Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motilityM Miyake
Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
J Exp Med 174:1347-54. 1991....
- Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNAS Ikeyama
Department VI, Takeda Chemical Industries, Ltd, Osaka, Japan
J Exp Med 177:1231-7. 1993..by monoclonal antibody (mAb) M31-15 inhibiting cell motility and that the sequence of MRP-1 coincides with that of CD9. In the present study, plasmid was constructed in which human MRP-1/CD9 cDNA is expressed under the control of the ..
- Lateral organization of membrane proteins: tetraspanins spin their webStephanie Charrin
INSERM, U, Villejuif, France
Biochem J 420:133-54. 2009....
- Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linkingOleg V Kovalenko
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Biochem J 377:407-17. 2004..Evidence for constitutive CD9 homodimers was obtained using several cell lines, utilizing the following four methods: (1) spontaneous cross-..
- Reduced motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancerM Higashiyama
Department of Surgery, Center for Adult Diseases of Osaka, Japan
Cancer Res 55:6040-4. 1995Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and ..
- HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3Eduardo Garcia
Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland
Traffic 9:200-14. 2008..stomatitis virus protein G colocalized in a viral compartment enriched in tetraspanins including CD81, CD82 and CD9, although at different levels, indicating a role of the viral envelope in targeting to the tetraspanin-rich ..
- A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9Koji Mitsuzuka
Pacific Northwest Research Institute, Seattle, Washington 98122, USA
J Biol Chem 280:35545-53. 2005..is highly dependent on the organization and function of microdomains composed of integrin, proteolipid/tetraspanin CD9, and ganglioside (Ono, M., Handa, K., Sonnino, S., Withers, D. A., Nagai, H., and Hakomori, S...
- CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanomaK J Radford
Oncology and Immunology Unit, David Maddison Clinical Sciences Building, Newcastle, New South Wales, Australia
Biochem Biophys Res Commun 222:13-8. 1996..These results are the first to demonstrate an association between CD63 and two other TM4SF members, CD9 and CD81 in 2 human melanoma cell lines...
- Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cellsJia Weng
Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
J Virol 83:7467-74. 2009..Overall, these data establish tetraspanins as negative regulators of HIV-1-induced cell-cell fusion, and they start delineating the requirements for this regulation...
- CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophagesEzequiel Ruiz-Mateos
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Virol 82:4751-61. 2008..into intracellularly sequestered plasma membrane domains that contain several other tetraspanins, including CD81, CD9, and CD53. CD63 is recruited to this domain following HIV infection...
- Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrinP M Sincock
Department of Medicine, The University of Adelaide, Australia
J Histochem Cytochem 45:515-25. 1997It has recently been shown that several members of the tetraspan superfamily, including CD9 and CD63, associate with each other and with beta1 integrins...
- Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteinsKei Sato
Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara cho, Sakyo ku, Kyoto, Kyoto 606 8507, Japan
J Virol 82:1021-33. 2008..In addition, these behaviors were commonly observed in other tetraspanin proteins, such as CD9, CD81, CD82, and CD231...
- Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domainsClare Jolly
The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
J Virol 81:7873-84. 2007..glycoprotein (Env) and the core protein (Gag) colocalize strongly with CD63 and CD81 and less strongly with CD9, whereas no colocalization was seen between Env or Gag and the late endosome/lysosomal marker Lamp2...
- CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)K R Park
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
Mol Hum Reprod 6:252-7. 2000Recently we reported that CD9 is involved in the invasion of a trophoblast-like choriocarcinoma cell line, BeWo, probably through the regulation of integrin functions...
- Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modificationsJia Chi Wang
McMaster University Medical Centre, Hamilton, Ontario, Canada
Clin Cancer Res 13:2354-61. 2007Cluster-of-differentiation antigen 9 (CD9) protein, a member of the tetraspanin family, has been implicated in carcinogenesis of various human tumors...
- Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrinsX A Zhang
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
J Biol Chem 276:25005-13. 2001..plasma membrane leads to their specific association with transmembrane-4 superfamily (TM4SF; tetraspanin) proteins (CD9, CD53, CD81, CD82, and CD151), as demonstrated by reciprocal co-immunoprecipitation and covalent cross-linking ..
- Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylationStephanie Charrin
INSERM U268, Hopital Paul Brousse, 94807 Cedex, Villejuif, France
FEBS Lett 516:139-44. 2002..All tetraspanins studied, CD9, CD37, CD53, CD63, CD81, CD82 and CD151, were found to incorporate [3H]palmitate...
- FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated proteinC S Stipp
Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
J Biol Chem 276:4853-62. 2001CD81 and CD9, members of the transmembrane-4 superfamily (TM4SF; tetraspanins), form extensive complexes with other TM4SF proteins, integrins, and other proteins, especially in mild detergents...
- Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactionsV Serru
INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
Biochem J 340:103-11. 1999..mild detergent, digitonin, dissociated most of these associated molecules, including integrins, from the tetraspans CD9, CD37, CD53, CD63, CD82, Co-029, Talla-1 and NAG-2...
- EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamilyC S Stipp
Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, Mssachusetts 02115, USA
J Biol Chem 276:40545-54. 2001..EWI-2 associated specifically with CD9 and CD81 but not with other tetraspanins or with integrins...
- Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusionMónica Gordón-Alonso
Servicio de Inmunologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
J Immunol 177:5129-37. 2006..Therefore, the role of CD81 and other related tetraspanin, CD9, on the cell-to-cell fusion process mediated by HIV-1 was studied...
- Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1Sascha Nydegger
Graduate Program in Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
J Cell Biol 173:795-807. 2006..Here, we reveal the presence of tetraspanin-enriched microdomains (TEMs) containing the tetraspanins CD9, CD63, CD81, and CD82 at the plasma membrane...
- The major CD9 and CD81 molecular partner. Identification and characterization of the complexesS Charrin
INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
J Biol Chem 276:14329-37. 2001..We have previously identified a 135-kDa molecule (CD9P-1) as a major molecular partner of CD9 in cancer cell lines...
- CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82G Horvath
INSERM U268, Hopital Paul Brousse, 94807 Villejuif Cedex, France
J Biol Chem 273:30537-43. 1998..4 transmembrane domains, member of the tetraspan superfamily, is engaged, together with other tetraspans such as CD9, CD53, CD63, and CD82, in multimolecular complexes containing beta1 integrins and major histocompatibility complex ..
- Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursorJoanna S Brooke
Dept of Biological Science, DePaul University, Chicago, IL 60614, USA
BMC Cell Biol 3:2. 2002..cDNA clones containing nucleotide sequences encoding domains of two proteins were obtained and their derived amino acid sequences were evaluated...
- Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivityR Iwamoto
Institute of Life Science, Kurume University, Fukuoka, Japan
EMBO J 13:2322-30. 1994DRAP27, the monkey homolog of human CD9 antigen (DRAP27/CD9) and diphtheria toxin receptor (DTR) were expressed in mouse L cells...
- CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspansS Lozahic
INSERM U268, Hopital Paul Brousse, Villejuif, France
Eur J Immunol 30:900-7. 2000..raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9. A unique mAb was identified which recognizes the complement regulator CD46 (membrane cofactor protein)...
- Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusionKeisuke Kaji
Department of Life Science, Tokyo Institute of Technology, Yokohama, 226 8501, Japan
Dev Biol 247:327-34. 2002b>CD9 is a membrane protein belonging to the tetraspanin family...
- A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrinMaria Dolores Gutierrez-Lopez
Instituto de Farmacologia y Toxicologia CSIC UCM, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
J Biol Chem 278:208-18. 2003..The tetraspanin CD9 has been implicated in cell motility, metastasis, and sperm-egg fusion...
- Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63V Horejsi
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
FEBS Lett 288:1-4. 1991..of the recently described leucocyte surface (glyco)-proteins with significant amino acid sequence similarity (human CD9, CD37, CD53, CD63, TAPA-1, CO-029 and R2 and several homologues of other species) are distinguished by the ..
- Calcium antagonist and antiperoxidant properties of some hindered phenolsG P Sgaragli
Istituto di Scienze Farmacologiche, Siena, Italy
Br J Pharmacol 110:369-77. 1993..8. Di-t-BHA is proposed as a lead reference compound for future synthesis of new antioxidants combining two potentially useful properties in the prevention of tissue damage after ischaemia reperfusion injury...
- Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytesL Folgueira
Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Virol 70:223-31. 1996..Altogether, these results suggest that atypical PKC isoenzymes, including PKC-zeta, participate in the signal transduction pathways by which HIV infection results in the activation of NF-kappa B in human monocytic cells and macrophages...
- Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channelsR L McDonald
Department of Pharmacology, University of Leeds
Br J Pharmacol 113:621-7. 1994..Keywords: SH-SY5Y; calcium channels; noradrenaline release; muscarinic receptor; nifedipine; w-conotoxin GVIA; pirenzepine;hexahydrosiladiphenidol..
- Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actionsJ Church
Department of Anatomy, University of British Columbia, Vancouver, Canada
Br J Pharmacol 113:499-507. 1994..Keywords: Ifenprodil; voltage-activated calcium channels; N-methyl-D-aspartate (NMDA); polyamines; cultured hippocampal pyramidal neurones..
- Evidence for an external location of the dihydropyridine agonist receptor site on smooth muscle and skeletal muscle calcium channelsC Strübing
Institut fur Biochemische Pharmakologie, Innsbruck, Austria
Br J Pharmacol 108:884-91. 1993..The DHP binding domain can be reached by agonists and antagonists from the extracellular but not from the intracellular face of the membrane...
- Modulation of calcium channel currents by arachidonic acid in single smooth muscle cells from vas deferens of the guinea-pigN Nagano
Department of Chemical Pharmacology, Faculty of Pharmacentical Science, Nagoya City University, Japan
Br J Pharmacol 116:1887-93. 1995..The inhibition of Ca channel current by AA may be partly induced by superoxide radicals derived from AA oxidation. PGF2A also reduces Ca channel currents but probably by a separate mechanism via activation of a GTP binding protein...
- Homing of the myeloma cell cloneK Vanderkerken
Department of Hematology-Immunology, Free University Brussels, Belgium
Acta Oncol 39:771-6. 2000..analysis we demonstrated that the stroma-dependent MM5 cells show a downregulation of the motility-related protein (MRP-I CD9) which might reflect the involvement of this molecule in the regulation of myeloma cell extravasation.
- The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot studyD A Fryburg
Division of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
Yale J Biol Med 68:19-23. 1995..These preliminary observations suggest that short-term treatment with beta-carotene may increase CD4+ cell counts in patients with AIDS who have greater than 10 cells/microliters...
- Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and CdJ Duguid
Department of Biochemistry, University of Minnesota, St Paul 55108
Biophys J 65:1916-28. 1993..Metal cation linkage of two displaced bases would allow separate DNA strands to crosslink. Aggregation is proposed to result from the formation of an extended network of these crosslinks...
- Intravenous immunoglobulin in symptomatic and asymptomatic children with perinatal HIV infectionL Olopoenia
Department of Pediatrics, DC General Hospital, Washington, DC 20012, USA
J Natl Med Assoc 89:543-7. 1997..However, symptomatic patients responded much better than the asymptomatic patients...
- Evaluation of surface tension and ion occupancy effects on gramicidin A channel lifetimeA Ring
Department of Physiology and Medical Biophysics, Uppsala University, Sweden
Biophys J 53:541-8. 1988..These effects of blockers, osmotic agents, and voltage on the lifetime, as well as the lack of effect of voltage at low salt levels, are consistent with the occupancy hypothesis...
- [Strip immunoblot assay (SIA) with recombinant antigens and synthetic peptide for detection of anti HIV-1 and HIV-2 antibodies]M Deguchi
Laboratory for Clinical Investigatio, Osaka University Hospital
Kansenshogaku Zasshi 75:371-81. 2001..The SIA method indicated the positive readings earlier than the WB1 assay. The present findings indicated that the SIA method was more specific and sensitive than the WB assay, and would be useful as a confirmatory test...
- Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the ratD Bleakman
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637
Br J Pharmacol 107:334-40. 1992..These results are consistent with a localized presynaptic inhibitory effect of NPY on glutamate release in hippocampal neurones in culture...
- Strychnine-induced potassium current in CA1 pyramidal neurones of the rat hippocampusS Ebihara
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan
Br J Pharmacol 106:823-7. 1992..7. When neurones were loaded with cholera toxin (CTX) or pertussis toxin (PTX) through a patch pipette, PTX suppressed the Str response whereas CTX did not, suggesting that G, and/or Go might be involved in the Str-induced IK...
- Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family membersJ Fullekrug
Cell Biology and Cell Biophysics Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Mol Biol Cell 10:1939-55. 1999....
- Kinin-induced chloride permeability changes in colony 29 epithelia estimated from 125I- efflux and MEQ fluorescenceL J MacVinish
Department of Pharmacology, University of Cambridge
Br J Pharmacol 108:469-78. 1993..7. It is concluded that LBK increases electrogenic chloride secretion in Colony 29 epithelia through the generation of second messengers cyclic AMP and Ca2+, each of which may act on both apical and basolateral membranes...
- K+ current stimulation by Cl- in the midgut epithelium of tobacco hornworm (Manduca sexta). II. Analysis of Ba(2+)-induced K+ channel conduction noiseW Zeiske
J Comp Physiol B 162:340-4. 1992..It seems likely that basolateral K+ channels (1) are subject to anionic gating ligands, and (2) depend on anions with respect to the rate of K+ transfer through an open K+ channel...
- The ambulatory care of HIV-infected persons: a survey of physician practice patternsM D Stein
Division of General Internal Medicine, Rhode Island Hospital, Providence 02903
J Gen Intern Med 7:180-6. 1992..Such incorporation might increase guideline acceptance by practicing clinicians...
- [A case of primary HIV-1 infection]H Sugiyama
Department of Internal Medicine, Teikyo University School of Medicine
Kansenshogaku Zasshi 71:949-52. 1997..Diagnosis of primary HIV-1 infection was made. Recently, HIV-1 infection has been increasing in Japan. Consideration of this disease in differential diagnosis of acute febrile illness is necessary...
- Ionic currents in cardiac myocytes of squid, Alloteuthis subulataM P Odblom
Marine Biological Association, Plymouth, UK
J Comp Physiol B 170:11-20. 2000..It also had a more transient time course, was activated at more negative potentials, and resembled the previously described low-voltage-activated, T-type calcium current...
- Detection of simian T-lymphotropic virus type I using the polymerase chain reactionC S Dezzutti
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210
Int J Cancer 50:805-10. 1992..Additionally, our data suggest that the tax and pol gene regions are conserved between HTLV-I and STLV-I strains found among these diverse species of non-human primates...
- Regulation of a voltage-dependent, calcium-activated K conductance by cyclic GMP in dissociated flounder enterocytesK E Cooper
Department of Physiology and Animal Sciences, University of Minnesota, St Paul 55108
J Comp Physiol B 163:581-6. 1993..l-1 Ba2+ to cells bathed in symmetric K Ringer's solution resulted in nearly complete inhibition of outward current. Charybdotoxin produced only minor effects on this current.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Differential in vitro anti-HIV activity of natural lignansH C Schroder
Abteilung Angewandte Molekularbiologie, Universitat Mainz, Bundesrepublik Deutschland
Z Naturforsch C 45:1215-21. 1990..Our results suggest that both compounds prevent the increase of topoisomerase II activity, involved in virus replication, after infection of cells with HIV-1...
- Boronate affinity adsorption of RNA: possible role of conformational changesN Singh
Department of Chemical Engineering, University of Houston, TX 77204-4792, USA
J Chromatogr A 840:205-13. 1999..The stoichiometric displacement parameter, Z, in Ba2+ buffer is three times the value in Mg2+ buffer, and is close to unity...
- Adenosine-induced hyperpolarization of the membrane voltage in rat mesangial cells in primary cultureH Pavenstadt
Department of Medicine, Albert Ludwigs University, Freiburg, Germany
Br J Pharmacol 113:7-12. 1994..6. The data indicate that adenosine activates K+-conductance via an A2 receptor in mesangial cells; the activation of the K+-conductance, which is probably mediated by cyclic AMP led to a hyperpolarization of membrane voltage...
- Effects of divalent cations and La3+ on contractility and ecto-ATPase activity in the guinea-pig urinary bladderA U Ziganshin
Department of Anatomy, University College London
Br J Pharmacol 114:632-9. 1995..5. In conclusion, the ability of some divalent cations to inhibit ecto-ATPase activity and to potentiate or inhibit contractile responses in the guinea-pig urinary bladder appear to be independent effects...
- Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptaseOSMOND J D'CRUZ
Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
Biol Reprod 67:1959-74. 2002....
- [Prevalence of HIV infection among stable female partners of seropositive men]S Kimura
Department of Infectious Diseases and Applied Immunology, University of Tokyo
Kansenshogaku Zasshi 67:95-101. 1993..01). HIV-p24 antigen was measured in 10 of 11 seropositive men. The antigen was positive in four men, and negative in six.(ABSTRACT TRUNCATED AT 250 WORDS)..
- The P2Z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATPJ S Wiley
Haematology Department, Austin Hospital, Heidelberg, Victoria, Australia
Br J Pharmacol 112:946-50. 1994....
- A study of the interaction between the Na+, K+ pump and Na+:Ca2+ exchange in macrophages and vascular smooth muscle cellsC Galli
INSERM U7, , Paris, France
Am J Hypertens 1:64S-70S. 1988..2',4'-Dimethylbenzamil was also able to inhibit Na+ efflux (by 3.05 +/- 0.98 mmol (L cells X h)-1; mean +/- SEM of three experiments) suggesting the existence of Na+:Sr2+ exchange.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudineM A Jacobson
Department of Medicine, University of California, San Francisco
- [The detection of human immunodeficiency virus type 1/2 antibody using synthetic peptides]P Mao
Department of Virology, 302nd Hospital of PLA, Beijing 100039
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:72-4. 1997..The reagent are stable at 37 degrees C for 4 days. The results indicated that our reagent is highly specific, sensitive and stable, it can be used for detection of HIV-1/2 infections...
- [Study on reverse transcriptase inhibiting antibody in plasma of HIV-1 seropositive subjects]T Saito
Department of Virology, Kanagawa Prefectural Public Health Laboratories
Kansenshogaku Zasshi 69:851-7. 1995..HIV strains were isolated from these 3 cases. These results suggest that reduction of RT inhibiting antibody levels correlate well with the success of HIV isolation and with progression of clinical manifestation...
- Analogies and differences between omega-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cellsL Gandia
Departamento de Farmacologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4, E 28029 Madrid, Spain
Pflugers Arch 435:55-64. 1997....
- Separation of calcium channel current components in mouse chromaffin cells superfused with low- and high-barium solutionsJ M Hernandez-Guijo
Instituto de Farmacología Teófilo Hernando y Departamento de Farmacología, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, E 28029 Madrid, Spain
Pflugers Arch 436:75-82. 1998....
- Re-evaluation of the P/Q Ca2+ channel components of Ba2+ currents in bovine chromaffin cells superfused with solutions containing low and high Ba2+ concentrationsA Albillos
Departamento de Farmacologia, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4 E 28029 Madrid, Spain
Pflugers Arch 432:1030-8. 1996..An R-type residual current is not present in these cells...
- [Studies on maternal transmission of HIV-1]Y Tabei
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health
Kansenshogaku Zasshi 69:858-63. 1995..None of the HIV-1 markers, except for antibody, was detected in the samples from their children and placenta. These facts strongly suggest that there was no HIV-1 transmission from mother to child...
- [Study on molecular epidemiology of Borna disease virus in Zunyi regions of Guizhou province]Chang ming Wang
Department of Neruology, 1st Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China
Zhonghua Liu Xing Bing Xue Za Zhi 29:1213-6. 2008..In order to study the epidemiology of Borna disease virus (BDV) in Zunyi region and its surrounding regions in Guizhou province...
- Ionic currents and inhibitory effects of glibenclamide in seminal vesicle smooth muscle cellsH Sadraei
Department of Pharmacology, University of Leeds
Br J Pharmacol 115:1447-54. 1995..In addition, an unexpected relaxant effect of high concentrations of glibenclamide may be explained by inhibition of the Ca channels...
- Didanosine therapy in patients intolerant of or failing zidovudine therapyR C Rathbun
Section of Pharmacy Practice, College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73190
Ann Pharmacother 26:1347-51. 1992..Also, development of peripheral neuropathy may occur at lower cumulative doses in these patient populations...
- Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infectionG Toedter
Coulter Immunology, Hialeah, Florida
AIDS Res Hum Retroviruses 8:527-32. 1992..Similarly, normal human peripheral blood mononuclear cells and uninfected, transformed human T cells, were also negative in the assay.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Measurement of HIV-1 p24 antigen by signal-amplification-boosted ELISA of heat-denatured plasma is a simple and inexpensive alternative to tests for viral RNAJorg Schupbach
Swiss National Center for Retroviruses, University of Zurich, Gloriastr 30, CH 8028 Zurich Switzerland
AIDS Rev 4:83-92. 2002..There is no problem with sample instability and no need for cumbersome nucleic acid extraction. The test is validated for subtype B, but requires further studies for non-B subtypes...
- Different modes of electrogenic Na+ absorption in the coprodeum of the chicken embryo: role of extracellular Ca2+M Heinz
, , Federal Republic of Germany
J Comp Physiol B 161:363-70. 1991..The results indicate that Na+ absorption in the coprodeum of the chicken embryo is more complex than in adult hens.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Separation and detection of common mono- and divalent cations by ion chromatography with an ODS column and conductivity/UV detectionK Ito
Department of Environmental Science, Faculty of Engineering, Hiroshima University, Japan
J Chromatogr A 850:247-56. 1999..CD detection was possible for M+ and M2+ and UV detection for M2+. (3) For M2+, the mobile phase, 0.8 mM Ce(III) + 0.1 mM SDS + 1 mM HNO3 and indirect UV detection were effective. The IC methods were applied to real samples...
- Sensitivity and specificity of anti-HIV ELISA employing recombinant (p24, p66, gp120) and synthetic (gp41) viral antigenic peptidesG Filice
Department of Infectious Diseases, University of Pavia, IRCCS Policlinico S Matteo
Microbiologica 14:185-94. 1991..b...
- Intracellular pH transients of mammalian astrocytesM Chesler
Department of Neurology, Cornell University Medical College, New York, New York 10021
J Neurosci 9:2011-9. 1989..The sensitivity of the response to Ba2+ suggests that it is triggered by membrane depolarization. These results suggest that glial pHi is normally modulated by the level of local neuronal activity...
- Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104PC Marbeuf Gueye
, , 74 rue Marcel Cachin, Bobigny, France
Eur J Pharmacol 391:207-16. 2000..A second mechanism involving a high-affinity site for PAK-104P and which would concern molecules such as anthracyclines, calcein acetoxymethyl ester whose efflux depends on the presence of glutathione...
- On the mechanisms of cholinergic control of the sinoatrial node dischargeM Vassalle
Department of Physiology and Pharmacology, State University of New York, Brooklyn 11203, USA
J Cardiovasc Pharmacol 37:173-86. 2001..The results with Cs+ and Ba2+ indicate that both high and low concentrations of carbachol decrease sinoatrial node discharge by activating the I(K,ACh) channels rather than by decreasing If...
- The effect of treatment with zidovudine with or without acyclovir on HIV p24 antigenaemia in patients with AIDS or AIDS-related complexC Pedersen
Hvidovre Hospital, Copenhagen, Denmark
AIDS 6:821-5. 1992..Change in antigen level in response to antiviral therapy needs further investigation before it is used as a surrogate marker for clinical efficacy of antiviral therapy...
- Preliminary comparison of precursor scans and liquid chromatography-tandem mass spectrometry on a hybrid quadrupole time-of-flight mass spectrometerC Borchers
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Chromatogr A 854:119-30. 1999..LC-MS-MS, therefore, appears to be better for the detection of trace components in complex mixtures...
- Dual and recombinant infections: an integral part of the HIV-1 epidemic in BrazilA Ramos
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 5:65-74. 1999....
- Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patientJ M Orenstein
Department of Pathology, George Washington University Medical Center, Washington, DC 20037, USA
AIDS 13:2219-29. 1999..To evaluate changes in architecture, viral RNA, and viral protein over 6 months in lymph nodes from retroviral-naïve HIV-infected persons before and after commencing highly active antiretroviral therapy (HAART)...
- [Analysis of immunophenotype and leukemia associated immunophenotype in 610 patients with acute myeloid leukemia]Yan Rong Liu
Peking University, Institute of Hematology, People s Hospital, Beijing, China
Zhonghua Xue Ye Xue Za Zhi 28:731-6. 2007..To analyze the immunophenotype and leukemia associated immunophenotype (LAIP) of leukemia cells from patients with acute myeloid leukemia (AML) in minimal residual disease (MRD) detection...
- Production and purification of immunologically active core protein p24 from HIV-1 fused to ricin toxin B subunit in E. coliAlberto J Donayre-Torres
Centro de Investigación y de Estudios Avanzados Cinvestav, Unidad Irapuato, Km 9 6 Libramiento Norte, 36500 Carretera Irapuato León, Irapuato, Guanajuato, Mexico
Virol J 6:17. 2009..The aim of this study was to investigate the adjuvant-carrier properties of the B ricin subunit (RTB) when fused to p24...
- Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24P S Barnett
Department of Medicine, King's College School of Medicine and Dentistry, London, UK
Cytogenet Cell Genet 62:188-9. 1993..Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24...
- Mechanisms underlying burst generation of the pyloric muscle in the mantis shrimp, Squilla oratoriaK Tazaki
Biological Laboratory, Nara University of Education, Japan
J Comp Physiol A 169:737-50. 1991....
- Progression to AIDS in patients with lymphadenopathy or AIDS-related complex: reappraisal of risk and predictive factorsH W Murray
Division of Infectious Diseases, Cornell University Medical College, New York, New York
Am J Med 86:533-8. 1989....
- Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replicationT Fitzon
Institute of Medical Microbiology, Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93053, Germany
Virology 268:294-307. 2000..These results suggest that proline residues in the NH(2)-terminal capsid domain represent critical structure determinants for proper formation of functional virion cores and subsequent stages of early replication...
- CD9-dependent regulation of Canine distemper virus-induced cell-cell fusion segregates with the extracellular domain of the haemagglutininK Singethan
Institut fur Virologie und Immunbiologie, Versbacher Strasse 7, D 97078 Wurzburg, Germany
J Gen Virol 87:1635-42. 2006Antibodies to CD9, a member of the tetraspan transmembrane-protein family, selectively inhibit Canine distemper virus (CDV)-induced cell-cell fusion...
- [Investigation of a new HIV-1 p24 antigen detection kit based on the enzyme-linked fluorescent immunoassay]T Hayashi
Department of Virology, Kanagawa Prefectural Public Health Laboratory
Kansenshogaku Zasshi 74:709-15. 2000..The results obtained suggest that ELFA are very useful for an earlier diagnosis of HIV infection and re-test for false positive samples by other HIV diagnosis kits...
- Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammationMayumi Suzuki
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
J Immunol 182:6485-93. 2009..In the present study, the role of tetraspanin CD9 in LPS-induced macrophage activation and lung inflammation was investigated in vitro and in vivo...
- Viral load, viral phenotype modification, zidovudine susceptibility and reverse transcriptase mutations during the first 6 months of zidovudine monotherapy in HIV-1-infected peopleS Rusconi
Clinica delle Malattie Infettive, Universita di Milano, Ospedale Luigi Sacco, Italy
Antivir Ther 1:211-9. 1996..076). SI phenotype was associated with the development of a decreased zidovudine susceptibility. A correlation between zidovudine-associated pol gene mutations and SI phenotype was detected at the 6-month time point...
- Quantification of human immunodeficiency virus type 1 p24 antigen and antibody rivals human immunodeficiency virus type 1 RNA and CD4+ enumeration for prognosis. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical J S Read
Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
Pediatr Infect Dis J 19:544-51. 2000....
- Ba2+ ions evoke two kinetically distinct patterns of exocytosis in chromaffin cells, but not in neurohypophysial nerve terminalsE P Seward
Department of Neurobiology and Anatomy, Medical College of Pennsylvania, Philadelphia 19129, USA
J Neurosci 16:1370-9. 1996..Only a single kinetic pattern is detected in NHP terminals, suggesting that mechanisms for secretion are not universally distributed in excitable cells...
- [Evaluation of an HIV screening assay kit for the combined detection of anti-HIV-1/2 antibodies and HIV p24 antigen]T Shima
Department of Virology, Kanagawa Prefectural Public Health Laboratory, Yokohama City University Hospital, School of Medicine
Kansenshogaku Zasshi 75:1014-24. 2001..All of these specimens were positive by Genscreen HIV Ag-Ab. Therefore, Genscreen HIV Ag-Ab that shorten the window period is a useful and reliable for HIV screening test, especially in case of primary infection...
- Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-kappaB-regulated gene productsKara A Boltz
Department of Biology, Texas A and M University, College Station, TX, USA
BMC Genomics 9:212. 2008..We tested the hypothesis that loss of Drosophila melanogaster p24 protein function causes a transcriptional response characteristic of ER stress activation...
- [HIV isolation and clinical markers on the seropositive subjects]T Otake
Osaka Prefectural Institute of Public Health
Kansenshogaku Zasshi 64:1287-94. 1990..These findings indicate that disease progression correlates with the appearance of variant viruses that are more infective and cytopathic...
- Expression regulation and functional characterization of a novel interferon inducible gene Gig2 and its promoterJun Jiang
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 7 Donghu South Road, Wuhan 430072, China
Mol Immunol 46:3131-40. 2009..Collectively, the data provide strong evidence that Gig2 is indeed a novel IFN inducible gene and its expression is likely dependent on IRF7 upon Poly I:C or IFN...
- RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesisMasaru Ishii
Department of Clinical Research, Osaka Minami Medical Center, Osaka, Japan
J Bone Miner Res 21:965-76. 2006We showed that CD9, a member of tetraspanin superfamily proteins, is expressed in a specific membrane microdomain, called "lipid raft," and is crucial for cell fusion during osteoclastogenesis after activation of the RANK/RANKL system.
Research Grants72
- BIOPHYSICAL/GENETIC PROPERTIES OF HIV1 IN HUMAN PLASMAGeorge Shaw; Fiscal Year: 2007..abstract_text> ..
- PLANT ANTI-HIV AGENTSKuo Hsiung Lee; Fiscal Year: 2003....
- C. Perfringens to Induce Anti-HIV Mucosal ImmunityPhalguni Gupta; Fiscal Year: 2006..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
- MDR Gene Polymorphisms in AMLMaria Baer; Fiscal Year: 2007..The project is expected to provide important information for use in improving AML treatment stratification and outcomes. ..
- Oral HIV Pathogenesis and SheddingScott Brodie; Fiscal Year: 2002..abstract_text> ..
- Oral HIV Pathogenesis and SheddingRobert Coombs; Fiscal Year: 2005..abstract_text> ..
- Pathogenesis of Oropharyngeal HHV-8 InfectionAndrew Johnson; Fiscal Year: 2005..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host. ..
- Tonsil Model of Oral HIV-1 Infection via BreastfeedingDiane Shugars; Fiscal Year: 2003....
- HIV-1 p24 based viral load assay in breast milk & serumANDRZEJ DRUKIER; Fiscal Year: 2002..This assay will also be used for VL testing of HIV-l Clade B-infected individuals as a first step towards a commercially viable assay. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUESGail Skowron; Fiscal Year: 2003..These relationships will be evaluated in the context of the clinical status of each patient group to be studied, and in comparison to HIV-uninfected subjects. ..
- Variation in platelet function: the genetics of platelet gene expressionPaul F Bray; Fiscal Year: 2010..of genes regulating the platelet response to specific agonists (ADP, CRP, collagen, TRAP, U46619, ristocetin, CD9 and epinephrine), as well as genes common to multiple platelet stimuli, and permit assessment of the effects of ..
- Vaccine with altered HIV antigensDanuta Kozbor; Fiscal Year: 2003..III) We will analyze protection levels achieved by DNA immunization with the modified Gag-Pol fusion constructs against intrarectal challenge with rVV expressing Gag and Pol proteins. ..
- TRANSMEMBRANE LINKER FUNCTIONS OF TM4SF PROTEINSMARTIN HEMLER; Fiscal Year: 2003Transmembrane-4 superfamily (TM4SF) proteins such as CD9, CD63, CD81 and CD82 regulate cell invasion, motility, fusion, signaling, and proliferation. The mechanisms whereby these proteins function are largely unknown...


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By Cappello & Noël, LLP
The fifth edition of Lender Liability (800 pages), the authoritative treatise on lender misconduct, is now available through Juris Publishing and is authored by the acknowledged pioneer in lender liability law, attorney A. Barry Cappello.
By Cappello & Noël LLP
A. Barry Cappello and Leila J. Noël, partners in the Santa Barbara law firm of Cappello & Noël LLP, have been named as two of the top attorneys in Southern California for 2013 by Super Lawyers Southern California magazine.
By Cappello & Noël
Cappello & Noël, LLP made a five-year financial commitment to support the Santa Barbara County Legal Aid Foundation. The Santa Barbara-based law firm announced it would donate $10,000 a year for five years to the non-profit organization.
By Cappello & Noel
A collapse of the commercial real estate sector will be catastrophic to financial institutions and the economy so lenders must act now to avoid such a financial debacle, says A. Barry Cappello, an attorney specializing in lender liability law.
By Cappello & Noel
Leila J. Noël named one of the "Top 75 Women Lawyers" in California by the Los Angeles and San Francisco Daily Journals. Noël was the only attorney selected from Santa Barbara, Ventura or San Luis Obispo Counties.
By Cappello & Noel LLP
Jury selection begins this week in Los Angeles Superior Court in a lending discrimination class action against Wells Fargo Bank. Class members are loan customers in minority communities in Los Angeles.
By Cappello & Noel
Cappello & Noël, LLP, one of the country's foremost complex commercial litigation law firms, has added three associates.
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