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Publications172 found, 100 shown here
- The brain tissue response to biodegradable poly(methylidene malonate 2.1.2)-based microspheres in the ratElvire Fournier
Inserm U646 Ingénierie de la vectorisation particulaire, 10 rue André Bocquel, 49 100 Angers, France
Biomaterials 27:4963-74. 2006..PMM 2.1.2 was thus shown to be inadequate for intracerebral drug delivery...
- Lewis acid-catalyzed conjugate additions of silyloxyallenes: a selective solution to the intermolecular Rauhut-Currier problemTroy E Reynolds
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA
Org Lett 10:2449-52. 2008..These latent allenolates undergo conjugate additions to alkylidene malonates in the presence of 10 mol % Sc(OTf) 3...
- MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatulaJian Zhao
Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
Plant Cell 23:1536-55. 2011..However, some flavonoid glycoside malonates accumulate to higher levels in MATE2 knockouts than in wild-type controls...
- SmI(2)-mediated carbon-carbon bond fragmentation in alpha-aminomethyl malonatesQiongfeng Xu
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Road, Beijing 100083, China
Org Lett 11:4136-8. 2009A new and efficient samarium diiodide-promoted carbon-carbon bond fragmentation reaction of alpha-aminomethyl malonates, taking place normally at room temperature and generating the corresponding deaminomethylation products in 74-94% ..
- Palladium-catalyzed carbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with imidoyl chlorides: an efficient route to substituted isoquinolin-1(2H)-onesZhaoyan Zheng
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
Org Lett 10:4903-6. 2008..were synthesized in reasonable to good yields by the palladium-catalyzed cyclization of diethyl(2-iodoaryl)malonates with imidoyl chlorides and carbon monoxide in tetrahydrofuran...
- Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coliS Hoenke
Mikrobiologisches Institut der Eidgenössischen Technischen Hochschule, Zurich, Switzerland
Eur J Biochem 246:530-8. 1997..As partial deletion of the mdcR gene impaired growth of the transformants on malonate, MdcR is probably a transcriptional regulator of the mdc genes...
- Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonateIsabel Lastres-Becker
URA CEA CNRS 2210, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, 4 Place du General Leclerc, 91401 Orsay Cedex, France
Neuroreport 14:813-6. 2003....
- Pd(II)-catalyzed asymmetric addition of malonates to dihydroisoquinolinesNaoki Sasamoto
IMRAM, Tohoku University, Miyagi 980 8577, Japan
J Am Chem Soc 128:14010-1. 2006We have developed a highly efficient reaction for catalytic asymmetric addition of malonates to dihydroisoquinolines using chiral Pd(II) complexes...
- Detection and quantification of glycosylated flavonoid malonates in celery, Chinese celery, and celery seed by LC-DAD-ESI/MSLong Ze Lin
Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, 103000 Baltimore Avenue, Beltsville, MD 20705, USA
J Agric Food Chem 55:1321-6. 2007..derivatives was confirmed by their conversion into glycosides upon heating and by comparison of some of the malonates with malonates that had previously been identified in red bell pepper and parsley...
- Nucleocytoplasmic-localized acyltransferases catalyze the malonylation of 7-O-glycosidic (iso)flavones in Medicago truncatulaXiao Hong Yu
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Plant J 55:382-96. 2008..Such C-terminal polypeptide deletion or deletion of the DFGWG motif alone led to improper folding of the transiently expressed GFP fusion protein in living cells, and impaired nuclear localization of the enzyme...
- Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiationMorimichi Hayashi
Toxicology Laboratories, Research and Development, Kissei Pharmaceutical Co Ltd, 2320 1 Maki, Hotaka, Minamiazumi gun, 399 8305 Nagano, Japan
Arch Toxicol 78:460-6. 2004..25 mg/kg per day KAT (by 64%). The results of the present study thus suggest that KAT inhibits the development of altered hepatocellular foci and might be a promising chemopreventive agent for hepatocarcinogenesis...
- The thyromimetic T-0681 protects from atherosclerosisIvan Tancevski
Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
J Lipid Res 50:938-44. 2009..Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans...
- Enzymic and genetic basis for bacterial growth on malonateP Dimroth
Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH Zentrum, Zurich, Switzerland
Mol Microbiol 25:3-10. 1997..The genetic evidence firmly supports the idea that malonate decarboxylation is carried out by the two different decarboxylases, as deduced from the biochemical studies of the enzymes...
- Malonate metabolism: biochemistry, molecular biology, physiology, and industrial applicationYu Sam Kim
Department of Biochemistry, College of Science, Protein Network Research Center, Yonsei University, Seoul 120 749, Korea
J Biochem Mol Biol 35:443-51. 2002..In addition to these, the genes matB and matC have been successfully used for generation of the industrial strain of Streptomyces for the production of antibiotics...
- Nephrotoxicity of heptaplatin: a randomized comparison with cisplatin in advanced gastric cancerJin Hee Ahn
Section of Hematology Oncology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138 736, Korea
Cancer Chemother Pharmacol 50:104-10. 2002..Heptaplatin is a newly developed platinum derivative which has been reported to be less toxic than cisplatin. This study was designed to evaluate the nephrotoxicity of heptaplatin in comparison with that of cisplatin...
- Characterization of novel astragaloside malonates from Radix Astragali by HPLC with ESI quadrupole TOF MSChu Chu
Key Laboratory of Modern Chinese Medicines China Pharmaceutical University, Ministry of Education, Nanjing, P R China
J Sep Sci 33:570-81. 2010..With the strategy of target precursor ions scan, a total of 22 astragalosides including 8 astragaloside malonates were screened and characterized from the methanolic extract of Radix Astragali by HPLC-Q-TOF/MS...
- Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectivelyPeter D Alfinito
Levine Neuroscience Laboratory, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci 23:10982-7. 2003..Interestingly, these effects are mediated by A1 and A2a receptors located in the substantia nigra for DAergic neurons and in the striatum for GABAergic neurons...
- Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomesWilliam F Maragos
Department of Neurology, Kentucky Clinic, Room L 445, University of Kentucky Medical Center, Lexington, KY 40536, USA
Biochem Pharmacol 63:1499-505. 2002..e. noncompetitive inhibition of the DAT...
- Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part II. Scope and applicationsB M Trost
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
J Am Chem Soc 123:3687-96. 2001..In conjunction with the subsequent reactions that occur with high stereospecificity, allylic gem-dicarboxylates serve as synthons for a double allylic transformation...
- Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient miceWilliam F Maragos
University of Kentucky, Department of Neurology, USA
Neurochem Res 29:741-6. 2004..These findings indicate that normal levels of MAO-A participate in expression of malonate toxicity by a mechanism involving oxidative stress...
- Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonateW L Nixdorf
Program in Basic and Clinical Neuroscience, Department of Psychiatry, Case Western Reserve University, Cleveland, USA
J Neurochem 77:647-54. 2001..Overall, these results highlight the importance of energy balance to the function of DA and 5-HT neurons and to the toxic effects of MDMA...
- Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performanceSéamus H McCooey
Centre for Synthesis and Chemical Biology, Department of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland
Angew Chem Int Ed Engl 44:6367-70. 2005
- Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporterLily Y Moy
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Pharmacol Exp Ther 320:747-56. 2007....
- Mechanisms of the interaction of nitroxyl with mitochondriaSruti Shiva
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biochem J 379:359-66. 2004....
- Organocatalytic conjugate addition of malonates to alpha,beta-unsaturated aldehydes: asymmetric formal synthesis of (-)-paroxetine, chiral lactams, and lactonesSven Brandau
The Danish National Research Foundation Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark
Angew Chem Int Ed Engl 45:4305-9. 2006
- Catalytic asymmetric Michael reactions with enamides as nucleophilesFlorian Berthiol
Graduate School of Pharmaceutical Sciences and Department of Chemistry, School of Science, The University of Tokyo, The HFRE Division, ERATO, JST, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Angew Chem Int Ed Engl 46:7803-5. 2007
- Ternary phase diagram for the Belousov-Zhabotinsky reaction-induced mechanical oscillation of intelligent PNIPAM colloidsJingyi Shen
Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, Texas 77843, USA
J Phys Chem A 111:12081-5. 2007....
- Enantioselective modular synthesis of 2,4-disubstituted cyclopentenones by iridium-catalyzed allylic alkylationMathias Schelwies
Organisch Chemisches Institut der Universitat Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
Angew Chem Int Ed Engl 45:2466-9. 2006
- Practical synthesis of optically active alpha,alpha-disubstituted malonamic acids through asymmetric hydrolysis of malonamide derivatives with Rhodococcus sp. CGMCC 0497Zhong Liu Wu
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
J Org Chem 68:2479-82. 2003..The enantioselectivity originated from the effects of a highly enantioselective amidase. The products could be converted to valuable (R)- or (S)-alpha,alpha-dialkylated amino acids after routine conversions...
- Strontium-catalyzed highly enantioselective Michael additions of malonates to enonesMagno Agostinho
Department of Chemistry, School of Science, The University of Tokyo, The HFRE Division, ERATO, JST, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Am Chem Soc 130:2430-1. 2008
- A general organocatalytic enantioselective malonate addition to alpha,beta-unsaturated enonesVeit Wascholowski
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Chemistry 14:6155-65. 2008A general enantioselective organocatalytic conjugate addition procedure of a variety of malonates to alpha,beta-unsaturated enone systems is presented. The reaction is efficiently catalysed by the pyrrolidinyl tetrazole catalyst 1...
- Desymmetrization-like catalytic enantioselective fluorination of malonates and its application to pharmaceutically attractive moleculesDhande Sudhakar Reddy
Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa Ku, Nagoya 466 8555, Japan
Angew Chem Int Ed Engl 47:164-8. 2008
- Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetinePeter S Hynes
School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom
Org Lett 10:1389-91. 2008....
- Manganese(III)-catalyzed free radical reactions on trimetallic nitride endohedral metallofullerenesChunying Shu
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060 0212, USA
J Am Chem Soc 129:15710-7. 2007..These are the highest levels of substitution of TNT metallofullerenes reported so far...
- Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicityJürgen G Okun
Department of Pediatrics, Division of Metabolic and Endocrine Diseases, Im Neuenheimer Feld 150, Federal Republic of Germany
J Biol Chem 277:14674-80. 2002..We propose that neuropathogenesis of methylmalonic aciduria may involve an inhibition of complex II and the tricarboxylic acid cycle by accumulating toxic organic acids, and synergistic secondary excitotoxic mechanisms...
- N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injuryC Demougeot
, Laboratoire de Pharmacodynamie, , Dijon, France Service de Neurologie, Centre Hospitalier Universitaire, Dijon, France
J Neurochem 77:408-15. 2001..Overall results show that cellular dysfunction can cause higher reductions in NAA level than neuronal loss, thus making of NAA quantification a potential tool for visualizing the penumbra area in stroke patients...
- Spectrophotometric study of fluorescence sensing and selective binding of biochemical substrates by 2,2'-bridged bis(beta-cyclodextrin) and its water-soluble fullerene conjugateYu Liu
Department of Chemistry, State Key Laboratory of Elemento organic Chemistry, Nankai University, Tianjin 300071, P R China
J Phys Chem B 109:23739-44. 2005....
- Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocyclineSylvie Cornet
Ipsen Institut Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis, France
Eur J Pharmacol 505:111-9. 2004..From these experiments, the neuroprotective activity of minocycline appears more related to its antiinflammatory activity than to a direct beneficial action on mitochondria...
- Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatumGail D Zeevalk
Department of Neurology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
Exp Neurol 176:193-202. 2002..These findings also point to fundamental differences between immature and adult neurons in the downstream involvement of GABA receptors during metabolic insult...
- A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivoLichuan Yang
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Neurobiol Dis 17:250-9. 2004..These findings suggest that systematically active broad-spectrum caspase inhibitors maybe useful in the treatment of neurodegenerative diseases such as PD and HD...
- Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicityA Meldrum
Centre for Brain Repair, Cambridge University, UK
Neuroreport 12:89-93. 2001..These data suggest that malonate-induced toxicity in the striatum depends upon the integrity of interactive influences from both glutamatergic and dopaminergic afferents...
- In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobeFrederic Pain
Institut de Physique Nucleaire, Interface Physique Biologie, 91406 Orsay, France
Proc Natl Acad Sci U S A 99:10807-12. 2002....
- Neuroprotective effects mediated by dopamine receptor agonists against malonate-induced lesion in the rat striatumR Fancellu
Laboratory of Functional Neurochemistry, IRCCS C Mondino, Pavia, Italy
Neurol Sci 24:180-1. 2003..Our data suggest that malonate- induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D1 and D2 agonists showing different profiles of efficacy...
- Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitroneAlexia Paucard
Laboratoire de Pharmacologie, UPRES EA2510, Universite Rene Descartes, 4 avenue de l Observatoire, 75006 Paris, France
Fundam Clin Pharmacol 19:57-64. 2005..Taken together, these results show that malonate induced a severe oxidative stress leading to the rapid development of the lesion. PBN demonstrates anti-edematous properties that are not sufficient to reduce the lesion...
- Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatumAlexia Paucard
Laboratoire de Pharmacologie, Universite Rene Descartes, 4 avenue de l Observatoire, 75006 Paris, France
Eur J Pharmacol 483:259-65. 2004..Thus NO production by the neuronal isoform of NO-synthase is not the major event leading to caspase activation due to malonate. However, NO seems to have pro- and anti-caspase effects that neutralize each other...
- Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the ratMarie Therese Armentero
Laboratory of Functional Neurochemistry, IRCCS, C Mondino, Pavia, Italy
Exp Neurol 178:301-5. 2002..Our data suggest that malonate-induced striatal toxicity can be attenuated by systemic administration of dopamine agonists, with D(1) and D(2) agonists showing different profiles of efficacy...
- Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibitionEvelise N Maciel
Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Brazil
J Neurochem 90:1025-35. 2004..We propose that under conditions in which mitochondrial complex II is partially inhibited in the CNS, neuronal cell death involves the induction of PT...
- Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptakeS R Mirandola
Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP 13083 887, Brazil
J Inherit Metab Dis 31:44-54. 2008....
- Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heartElena Maklashina
Molecular Biology Division, VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
FEBS Lett 556:64-8. 2004..In addition, these studies show that complex II is fully active in the mitochondrion and not inhibited by OAA regardless of the oxygen concentration...
- The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioningAndrew P Wojtovich
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
Biochim Biophys Acta 1777:882-9. 2008..Together, these observations suggest that complex II inhibition by endogenously formed malonate may represent an important activation pathway for mK(ATP) channels during IPC...
- Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic culturesJulie Ehrhart
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
J Neurochem 86:1487-97. 2003..It is speculated that these events are linked by glutaredoxin, an enzyme shown to contain both dehydroascorbate reductase as well as glutathione thioltransferase activities...
- Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part I. Asymmetric addition of malonate nucleophilesB M Trost
Department of Chemistry, Stanford University, Stanford, California 94305, USA
J Am Chem Soc 123:3671-86. 2001Asymmetric alkylations of allylic geminal dicarboxylates with dialkyl malonates have been investigated...
- 3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitorsAlexey Rivkin
Department of Chemistry, Merck Research Laboratories, Boston, MA 02115, USA
Bioorg Med Chem Lett 16:4620-3. 2006..Starting from a derivative with an IC(50) = 1.4 microM, SAR studies led to compounds with more than 70-fold increase in potency (IC(50) < 20 nM)...
- Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligandsNeil A Beare
Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
J Org Chem 67:541-55. 2002..reactions of aryl bromides and chlorides with two common stabilized carbanions-enolates of dialkyl malonates and alkyl cyanoesters-are reported...
- Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthaseYue Ma
School of Chemistry, University of Bristol, Cantock s Close, Clifton, Bristol, BS8 1TS, UK
Chembiochem 7:1951-8. 2006..The NSAS holo-ACP was also active in actinorhodin minimal PKS assays, but only in the presence of exogenous malonyl transferases...
- Improved reagent for electrophilic amination of stabilized carbanionsJason A Smulik
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
Org Lett 5:4187-90. 2003..Reagent 2 reacts efficiently with stabilized sodium or potassium enolates derived from malonates, phenylacetates, and phenylacetonitriles and is sufficiently soluble for use in solution at -78 degrees C.
- The decarboxylative Blaise reactionJae Hoon Lee
Chemical Development Division, LG Life Sciences, Ltd R and D, 104 1 Moonji dong, Yusong gu, Daejeon 305 380, Korea
J Org Chem 72:10261-3. 2007..Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lacrimatory reagent, and is possible with 0.5-1.0 equiv of zinc chloride...
- Quantitating the effect of an ortho substituent on cyclization and intramolecular hydrogen-transfer reactions of aryl radicalsDennis P Curran
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Org Chem 68:2972-4. 2003Reduction of allyl 2-iodobenzyl malonates with triphenyltin hydrides generates aryl radicals that partition between 6-exo cyclization, 7-endo cyclization, and 1,5-hydrogen atom transfer...
- Zn(II)/amine-catalyzed coupling reaction of alkylidenemalonates with propargyl alcohol: a one-pot synthesis of methylenetetrahydrofuransMasaharu Nakamura
Department of Chemistry, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Org Lett 6:2015-7. 2004..In the presence of catalytic amounts of zinc triflate [Zn(OTf)(2)] and triethylamine (Et(3)N), various 2-alkylidene-1,3-dicarbonyl compounds reacted with propargyl alcohol to give 3- or 4-methylene tetrahydrofurans in excellent yields...
- Boc-protected amines via a mild and efficient one-pot Curtius rearrangementHélène Lebel
Departement de Chimie, Universite de Montreal, P O Box 6128, Station Downtown, Montreal, Quebec, Canada H3C 3J7
Org Lett 7:4107-10. 2005..These reaction conditions are compatible with a variety of substrates, including malonate derivatives, which provide access to protected amino acids...
- Synthesis of indenes by the transition metal-mediated carboannulation of alkynesDaohua Zhang
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
J Org Chem 72:251-62. 2007..The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method...
- ESI-MS studies on the mechanism of Pd0-catalyzed three-component tandem double addition-cyclization reactionHao Guo
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P R China
J Am Chem Soc 127:13060-4. 2005..characterized by the high-resolution ESI-FTMS technology, on the basis of which a mechanism was proposed for the Pd0-catalyzed three-component tandem double addition cyclization of organic halides, 2-(2,3-allenyl)malonates, and imines.
- Conformations, energies, and intramolecular hydrogen bonds in dicarboxylic acids: implications for the design of synthetic dicarboxylic acid receptorsThanh Ha Nguyen
Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
J Comput Chem 26:1233-41. 2005..Intramolecular H-bond redshifts of 170-250 cm(-1) have been estimated from the results of the harmonic frequency analyses...
- A convenient method for the efficient removal of ruthenium byproducts generated during olefin metathesis reactionsY M Ahn
Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66044, USA
Org Lett 3:1411-3. 2001..Treatment of the crude reaction products with triphenylphosphine oxide or dimethyl sulfoxide, followed by filtration through silica gel, was found to be a practical and effective method to remove colored ruthenium byproducts...
- Efficient removal of ruthenium byproducts from olefin metathesis products by simple aqueous extractionSoon Hyeok Hong
The Arnold and Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Org Lett 9:1955-7. 2007..Simple aqueous extraction removed ruthenium byproducts efficiently from ring-closing metathesis (RCM) reactions catalyzed by a poly(ethylene glycol) (PEG) supported N-heterocyclic carbene-based ruthenium complex...
- Novel autoxidation and Michael addition of a butenolide-containing sugar leading to a C-branched-chain glucopyranosidulose, and X-ray structure of intermediatesHong Min Liu
Department of Chemistry, Zhengzhou University, Daxue Road, Zhengzhou 450052, PR China
Carbohydr Res 338:1737-43. 2003..The autoxidations are also performed in weakly basic, neutral and weakly acidic medium, respectively...
- Michael addition of ortho-lithiated aryloxiranes to alpha,beta-unsaturated malonates: synthesis of tetrahydroindenofuranonesAntonio Salomone
Dipartimento Farmaco Chimico, Universita di Bari, Consorzio Interuniversitario Nazionale Metodologie e Processi Innovativi di Sintesi, Via E Orabona 4, I 70125 Bari, Italy
Org Lett 10:1947-50. 2008..of tetrahydroindenofuranones based on the Michael addition of ortho-lithiated aryloxiranes to alkylidene malonates followed by the nucleophilic oxirane ring-opening and subsequent lactonization is described...
- Convenient syntheses and transformations of 2-C-malonyl carbohydratesJian Yin
Department of Chemistry, University of Potsdam, Karl Liebknecht Strasse 24 25, 14476 Potsdam, Germany
Chemistry 13:10152-67. 20072-C-malonyl carbohydrates were synthesized in only few steps and high yields by radical additions of malonates to glycals...
- Regioselective tandem dimethylsulfonium methylide addition-eliminative olefination of diendioates: a novel route to 1,3-butadien-2-ylmalonatesRekha Singh
Bio Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
Org Lett 9:5071-4. 2007....
- Enantioselective syntheses of tremulenediol A and tremulenolide ABrandon L Ashfeld
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
Org Lett 7:4535-7. 2005..This strategy was applied to the first enantioselective syntheses of tremulenediol A and tremulenolide A...
- Preparation of pyrrolidine-based PDE4 inhibitors via enantioselective conjugate addition of alpha-substituted malonates to aromatic nitroalkenesPaul J Nichols
Department of Process Chemistry Research, Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, USA
Org Lett 8:1495-8. 2006reaction: see text] The enantioselective conjugate addition of alpha-substituted malonates to aromatic nitroalkenes generates a stereocenter at the carbon bearing the aromatic group and an adjacent prochiral center from the alpha-..
- A practical synthesis of (+/-)-alpha-isosparteine from a tetraoxobispidine corePaul R Blakemore
Department of Chemistry, Oregon State University, Corvallis, Oregon 97331 4003, USA
Org Lett 7:4721-4. 2005..Tetraoxobispidine 7 was itself prepared in three simple operations from dimethyl malonate. The entire sequence to alpha-isosparteine was conducted on a multigram scale and proceeded without recourse to chromatography...
- gem-Dibromomethylarenes: a convenient substitute for noncommercial aldehydes in the knoevenagel-doebner reaction for the synthesis of alpha,beta-unsaturated carboxylic acidsJohn Kallikat Augustine
Syngene International Ltd, Biocon Park, Plot Nos 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 100, India
J Org Chem 72:9854-6. 2007..gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of alpha,beta-unsaturated carboxylic acids...
- LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeansQingli Wu
New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and Pathology, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey, USA
J Agric Food Chem 52:2763-9. 2004..a total 16 isoflavones, including three aglycones, three glycosides, two glycoside acetates, and eight glycoside malonates. The major isoflavones in soybean seeds were daidzein and genistein glycoside and their malonate conjugates...
- Determination of isoflavones in red clover and related species by high-performance liquid chromatography combined with ultraviolet and mass spectrometric detectionQingli Wu
New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and Pathology, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA
J Chromatogr A 1016:195-209. 2003..The separated isoflavones including aglycones, glycosides and glycoside malonates, were individually analyzed and identified by their molecular ions and characteristic fragment ion peaks using ..
- Flavonoids in Leguminosae: analysis of extracts of T. pratense L., T. dubium L., T. repens L., and L. corniculatus L. leaves using liquid chromatography with UV, mass spectrometric and fluorescence detectionEva de Rijke
Department of Analytical Chemistry and Applied Spectroscopy, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
Anal Bioanal Chem 378:995-1006. 2004..In T. pratense and T. repens, the main constituents were flavonoid glucoside-(di)malonates, while T. dubium and L. corniculatus mainly contained flavonoid (di)glycosides...
- Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in EstoniaKati Helmja
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
Nat Prod Res 25:496-510. 2011..to the earlier published polyphenols, several new phenolic acids and flavonoids, such as quercetin hexoside malonates and an A-type catechin-epicatechin trimer were identified in this Hypericum for the first time...
- Phosphoramidites are efficient, green organocatalysts for the Michael reaction. Mechanistic insights into the phosphorus-catalyzed Michael reaction of alkynones and implications for asymmetric catalysisRobert B Grossman
Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
J Org Chem 68:871-4. 2003..phosphites have been found to be efficient catalysts for the Michael reaction of alkenones and alkynones with malonates, alpha-cyano esters, beta-keto esters, and nitro compounds...
- LC-ESI-MS study of the flavonoid glycoside malonates of red clover (Trifolium pratense)L Z Lin
Research Laboratory of Natural Products Chemistry, A M Todd Botanicals, Eugene, Oregon 97402, USA
J Agric Food Chem 48:354-65. 2000..ionization-mass spectrometry (LC-ESI-MS) was applied to the analysis of the flavonoids and their glycoside malonates of the flowers and leaves of red clover (Trifolium pratense)...
- Phenolic compounds and chromatographic profiles of pear skins (Pyrus spp.)Long Ze Lin
Food Composition and Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705 3000, USA
J Agric Food Chem 56:9094-101. 2008..Peckham, Red, Red D'Anjou, and Seckel) contained significant quantities of isorhamnetin glycosides and their malonates and lesser quantities of quercetin glycosides...
- Catalytic asymmetric ring-opening of meso-aziridines with malonates under heterodinuclear rare earth metal Schiff base catalysisYingjie Xu
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Am Chem Soc 133:5791-3. 2011Catalytic asymmetric ring-opening of meso-aziridines with malonates is described. The combined use of two rare earth metal sources with different properties promoted the desired ring-opening reaction...
- Enantioselective Friedel-Crafts alkylation of indoles with trifluoroethylidene malonates by copper-bis(oxazoline) complexes: construction of trifluoromethyl-substituted stereogenic tertiary carbon centerLele Wen
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Rd, Shanghai, 200032, China
J Org Chem 76:2282-5. 2011An enantioselective alkylation of indoles with trifluoroethylidene malonates catalyzed by copper(II)-bis (oxazoline) complexes has been developed...
- Mechanistic studies on the catalytic asymmetric Mannich-type reaction with dihydroisoquinolines and development of oxidative Mannich-type reactions starting from tetrahydroisoquinolinesChristian Dubs
Synthetic Organic Chemistry Laboratory, RIKEN 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
J Org Chem 73:5859-71. 2008Detailed mechanistic studies on our recently reported asymmetric addition reactions of malonates to dihydroisoquinolines (DHIQs) catalyzed by chiral Pd(II) complexes were carried out...
- Enantioselective and regioselective organocatalytic conjugate addition of malonates to nitroenynesXiao Jiao Li
Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091 China
Chem Asian J 6:220-5. 2011..Notably, the protocol worked well with both aryl- and alkyl-substituted alkynyl substrates...
- Synthesis of Dibenz[b,f]oxepins via Manganese(III)-Based Oxidative 1,2-Radical RearrangementZhiqi Cong
Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, Kurokami 2 39 1, Kumamoto 860 8555, Japan
J Org Chem 74:3978-81. 2009The oxidation of monoalkyl 2-(9H-xanthenyl)malonates 1 with Mn(OAc)(3) gave the 9- or 10-dibenz[b,f]oxepincarboxylates 2 in good yields...
- Asymmetric electrophilic amination of various carbon nucleophiles with enantiomerically pure chiral N-h oxaziridines derived from camphor and fenchonePhilip C Bulman Page
Department of Chemistry, Loughborough University, Leicestershire LE11 3TU, England
J Org Chem 67:7787-96. 2002..Nitrogen is transferred, together with the camphor/fenchone unit, when deprotonated esters, malonates, and nitriles are used as nucleophiles...
- Lewis Base-Promoted Hydrosilylation of Cyclic Malonates: Synthesis of beta-Substituted Aldehydes and gamma-Substituted AminesChristopher G Frost
Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom
J Org Chem 74:3599-602. 2009The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of beta-substituted aldehydes...
- High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: ribes speciesKaisu R Määttä
Institute of Applied Biotechnology and Food and Health Research Centre, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
J Agric Food Chem 51:6736-44. 2003..However, cyanidin 3-O-sambubioside and quercetin hexoside-malonate were notable phenolic compounds in red currant. Flavonol hexoside-malonates were identified and quantified in the berries of currants for the first time.
- Ytterbium-catalyzed conjugate allylation of alkylidene malonatesCharlene Fallan
EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, The King s Buildings, West Mains Road, Edinburgh, EH9 3JJ, United Kingdom
J Org Chem 76:4112-8. 2011Alkylidene malonates undergo efficient conjugate allylation upon treatment with allylstannanes or allylsilanes under the action of ytterbium catalysis.
- Stereoselective synthesis of 2-carbamoyl-2-cyanocyclopropanecarboxylates by tandem oxidative cyclization and neighboring group-assisted decarboxylationHua Wang
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
J Org Chem 75:6994-7. 2010..neighboring group-assisted decarboxylation of the Michael adducts of 2-cyanoacetamides with α,β-unsaturated malonates. This method affords the desired highly functionalized cyclopropanes in moderate to good yields and with ..
- Synthesis of new C2- symmetric fluoren-9-ylidene malonate derived bis(oxazoline) ligands and their application in Friedel-Crafts reactionsJing Li
Department of Applied Chemistry, China Agricultural University, Beijing 100193, China
Molecules 15:8582-92. 2010..Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene malonates were evaluated, and the Cu(OTf)2 complex of a fluoren-9-ylidene malonate-derived bis(oxazoline) bearing a phenyl ..
- A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C-N coupling/Michael addition reactionsMichael C Willis
Department of Chemistry, University of Bath, Bath BA2 7AY, UK
Org Biomol Chem 3:3094-5. 2005..can be used to convert vinyl bromides to the corresponding enamines, which are reacted in situ with alkylidene malonates to provide Michael adducts. The overall transformation results in cine-substitution of the starting vinyl bromide...
- Development of microwave assisted extraction for the simultaneous determination of isoflavonoids and saponins in radix astragali by high performance liquid chromatographyJing Zheng Song
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, China
J Sep Sci 30:819-24. 2007..It was found that flavonoid glycoside malonates were converted into their related glycosides during the prolonged conventional extraction, thus affecting the ..
- Highly enantioselective synthesis of α,α-dialkylmalonates by phase-transfer catalytic desymmetrizationSuckchang Hong
Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151 742, Korea
J Am Chem Soc 133:4924-9. 2011A novel enantioselective synthetic method for the construction of a quaternary carbon center from malonates via phase-transfer catalytic (PTC) alkylation has been developed...
- Water-compatible iminium activation: highly enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated enonesZhifeng Mao
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 China
J Org Chem 75:7428-30. 2010The highly enantioselective Michael addition of malonates to α,β-unsaturated ketones in water was reported to be catalyzed by a primary-secondary diamine catalyst containing a long alkyl chain...
- Hydrogen bond directed highly regioselective palladium-catalyzed allylic substitutionGregory R Cook
Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105 5516, USA
J Am Chem Soc 125:5115-20. 2003..to be directed to the internal carbon (branched:linear, 75:25 to >98:2), whereas sulfonamides, amines, and malonates added only to the terminal carbon of the allyl complex...
- Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylatesTiantian Wang
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
Bioorg Med Chem Lett 21:3381-3. 2011..were prepared through the metal-catalyzed domino reaction of alkylidene malonates and 1,4-butynediol under a one-pot reaction condition at room temperature...
- Enantioselective organocatalytic Michael addition of aldehydes to trifluoroethylidene malonatesLele Wen
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PRC
Org Lett 12:4655-7. 2010..highly enantioselective, organocatalytic Michael addition reaction of aldehydes with trifluoroethylidene malonates is described...
- Palladium-catalyzed cyclocarbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with vinyl ketones affording functionalized enolic 2-acyl-3,4-dihydronaphthalenonesZhaoyan Zheng
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
Org Lett 11:3278-81. 2009..moderate to excellent yields by the palladium-catalyzed cyclocarbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with vinyl ketones and carbon monoxide...
- Highly enantioselective Michael addition of malonates to beta,gamma-unsaturated alpha-ketoesters catalyzed by chiral N,N'-dioxide-Yttrium(III) complexes with convenient procedureLin Zhou
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China
Chem Commun (Camb) 46:3601-3. 2010Highly enantioselective Michael addition of malonates to beta,gamma-unsaturated alpha-ketoesters has been promoted by chiral N,N'-dioxide-Yttrium(iii) complexes, providing the corresponding products in excellent yields with 94-99% ee ..
- Asymmetric three- and [2 + 1]-component conjugate addition reactions for the stereoselective synthesis of polysubstituted piperidinonesStephen G Davies
Department of Organic Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK
Org Biomol Chem 5:1405-15. 2007..Asymmetric three-component couplings of alpha,beta-unsaturated esters and alkylidene malonates initiated by lithium amide conjugate addition proceeds with high levels of 2,3-anti stereoselectivity, with ..
Research Grants110 found, 100 shown here
- RATIONAL DESIGN OF CATALYSTS FOR C-C BOND FORMATIONJohn Hartwig; Fiscal Year: 2002..have now extended this reaction to include the alpha-arylation of carboxylic acid derivatives such as amides and malonates, while finding remarkable catalysts that provide alpha-arylation of ketones at room temperature using aryl ..
- Catalytic Carbon-Carbon Bond Forming ReactionsJohn Hartwig; Fiscal Year: 2006..Although arylations of ketones, esters, malonates and cyanoesters now occur efficiently with several types of aryl halides, the reactions of other common carbonyl ..
- Dopamine Toxicity in Models of Huntington's DiseaseWilliam Maragos; Fiscal Year: 2004..The results of these studies will demonstrate the critical role that metabolism of dopamine plays in striatal neuron death in Huntington's disease and offer a potentially novel therapeutic approach for the treatment of this disorder. ..
- METHAMPHETAMINE AND HIV PROTEIN-INDUCED NEUROTOXICITYWilliam Maragos; Fiscal Year: 2005..To accomplish these goals, we will assess the effects of intrastriatal injections of virotoxins in animals treated with methamphetamine and in vitro in human cortical neurons where cell types can be manipulated. ..
- Metabolic engineering of the methylmalonyl-CoA node in S. erythreaJ Weber; Fiscal Year: 2007..The technology that will be developed in this project will elucidate path- ways leading to the biosynthesis of commercially important antibiotics with a focus on erythromycin. ..
- Engineering metabolic flow for rapamycin productionJ Weber; Fiscal Year: 2005..This will be the first test of this technology for a drug other than erythromycin, and will help to establish the general applicability of the strategy for strain improvement. ..
- GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURYLawrence Lash; Fiscal Year: 1999..These results will ultimately help in development of procedures to maintain or improve kidney function. ..
- Synthesis of Polyketides and TerpenesDavid A Evans; Fiscal Year: 2010..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
- STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLYAlexander McPherson; Fiscal Year: 2002..This research is significant because the conformation of the nucleic acid component of no spherical virus is currently known, and there is presently no comprehensive structural basis for the processes of viral assembly and disassembly. ..
- Canine Multiple System Degeneration: A Novel Animal Model of ParkinsonismDENNIS O BRIEN; Fiscal Year: 2007..This research will develop a novel animal model of the disease which can be used to test theories about the cause and develop new therapies. ..
- Fluorous Mixture Synthesis of Natural Product LibrariesDENNIS CURRAN; Fiscal Year: 2007..To prove the concept, first eight diastereomers and later all sixteen isomers of passifloricin A will be synthesized. ..
- Purchase of a 600 MHz NMR Spectrometer with CryoprobeDENNIS CURRAN; Fiscal Year: 2007..This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work. ..
- CHEMICAL MECHANISMS OF BIOSYNTHESISRichard Wolfenden; Fiscal Year: 2009....
- ASYMMETRIC THERMAL ADDITION AND CYCLOADDITION REACTIONSDENNIS CURRAN; Fiscal Year: 1993..However, exciting preliminary results indicate that these goals are realistic, and that original and powerful solutions to important problems in the synthesis of biomedically active compounds will be forthcoming...
- GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURYLawrence Lash; Fiscal Year: 1993..These results will ultimately help in development of procedures to maintain or improve kidney function...
- SYNTHESIS OF AMINO ACID-DERIVED NATURAL PRODUCTSDavid Evans; Fiscal Year: 1990..For example, amino acid syntheses based upon the development of chiral glycine enolate synthons, chiral electrophilic aminating agents, and chiral metal nitrenoids are presented...
- METAL CATALYZED CARBON-CARBON FORMING REACTIONSJAMES TAKACS; Fiscal Year: 1990....
- STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLYAlexander McPherson; Fiscal Year: 2006..This research is significant because the conformation of the nucleic acid component of no virus is currently known, nor is there any comprehensive structural basis for the processes of viral assembly and disassembly. ..
- Excitotoxic Signaling in HD Transgenic NeuronsKARI HOYT; Fiscal Year: 2004..The cell culture models of HD proposed in this work should also provide a convenient means for testing relevant therapies for HD. ..
- MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLSLawrence Lash; Fiscal Year: 2005..abstract_text> ..
- FLUOROUS REAGENTS IN TRADITIONAL/COMBINATORIAL SYNTHESISDENNIS CURRAN; Fiscal Year: 1999....
- FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESISDENNIS CURRAN; Fiscal Year: 2003..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..
- METAL CATALYZED CARBON - CARBON BOND FORMING REACTIONSJAMES TAKACS; Fiscal Year: 1993..Part 4 describes investigations into defining other new, but mechanistically related, carbocyclization reactions...
- SYNTHESIS VIA SEQUENTIAL FREE RADICAL REACTIONSDENNIS CURRAN; Fiscal Year: 1991..The chemistry outlined int his proposal will contribute both to the understanding of free radical reactions and to the ability to prepare important cyclopentanoid natural products...
- TRANSITION METAL CATALYZED C-C BONDING FORMING REACTIONJAMES TAKACS; Fiscal Year: 2002..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
- RADICAL REACTIONS FOR NATURAL PRODUCTSDENNIS CURRAN; Fiscal Year: 2002....
- MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLSLawrence Lash; Fiscal Year: 2007..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney ..
- ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITYGail Zeevalk; Fiscal Year: 2007..The studies will have relevance to neurodegenerative conditions or pathophysiological situations in which metabolism is compromised. ..
- Carbon Antioxidants to Prevent Diabetic ComplicationsMICHAEL DIENER; Fiscal Year: 2007....
- Molecular Cages for Alpha Particle RadioimmunotherapyMICHAEL DIENER; Fiscal Year: 2002..The development of such a therapy has a potential market of approximately 300,000 Americans/yr. ..
- MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLSLawrence Lash; Fiscal Year: 2001....


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The six choirs of the Salt Lake Choral Artists are holding auditions for their 2012-2013 concert and touring season.
This year's season will feature music ranging from music in memory of the Titanic to jazz music by Duke Ellington, along with Andrew Lloyd Webber, Morten Lauridsen and Handel thown in.
Members of all the adult choirs will have the opportunity to travel to Israel in January, and the newly-formed Men's Choir will travel to France. The Salt Lake Vocal Artists will travel to Bulgaria in May.
Auditions will be held from August 2-20.
All voice parts welcome, but tenors and basses are especially encouraged to audition for the Men's Choir.
To schedule an audition for the Concert, Chamber, Women's, or Men's Choir or the Salt Lake Vocal Artists, contact audition coordinator Lee Pratt via email (email@example.com) or phone (801-556-3216 or 435-783-2749).
Young singers interested in joining the Young Choral Artists should contact John Walker (email@example.com) or Joan Brinton (email@example.com).
Visit the Salt Lake Choral Artists homepage (www.saltlakechoralartists.org) for more information.

subset: commoncrawl


text:
Filmlinc DailyRSS
Daily Buzz: SXSW Episode 6
On our penultimate podcast from SXSW, Eugene Hernandez talks with the filmmakers behind Maladies, The Retrieval, and Good Ol' Freda, as well as Tim League of Austin's Alamo Drafthouse theaters.
Daily Buzz: SXSW Episode 5
Jeffrey Schwarz talks about his new doc I Am Divine about John Waters's muse and collaborator, plus interviews with the filmmakers behind The Bounceback and Los Wild Ones and SXSW Film head Janet Pierson reflects on the fest (so far).
Daily Buzz: SXSW Episode 4
"I want to create in the way I want to create. I want to move as fast as I can think." Harmony Korine talks filmmaking and Spring Breakers, plus interviews with John Sayles and Edward James Olmos about their new film Go for Sisters.
Daily Buzz: SXSW Episode 3
Malcolm Ingram discusses his documentary Continental about the history of NYC's most famous gay bathhouse, plus a critical recap of the first weekend of SXSW Film and an unexpected story of being bandmates with Jim Jarmusch.
Daily Buzz: SXSW Episode 2
On day two at SXSW, Shane Carruth stopped by the Daily Buzz studio in the Stateside Theater to discuss his highly anticipated new film Upstream Color. Perhaps surprisingly, he described it as an essentially romantic tale.
Daily Buzz: SXSW Episode 1
Television, digital content distribution, and piracy were hot topics on day one of Film Society's Daily Buzz with Eugene Hernandez podcast from SXSW, plus interviews with the filmmakers behind TINY, TPB AFK, and Sake Bomb.
Film Society's Daily Buzz Hits SXSW
Hear that Austin? That's the sound of Eugene Hernandez's daily festival podcast bringing you all the film news from South by Southwest every night at 9:00pm thanks to our broadcast partner KUT, and via iTunes!
Daily Buzz: Sundance Episode 8
We cap off our Sundance podcasts with an interview with David Lowery, who had his hand in three of the most talked-about features at this year's festival: he wrote and directed Ain't Them Bodies Saints, co-wrote Yen Tan's Pit Stop, and co-edited Shane Carruth's Upstream Color.
Daily Buzz: Sundance Episode 7
Actors Josh Radnor and Kathryn Hahn discuss Jill Soloway's Afternoon Delight and the relationship between television and indie film, plus RJ Cutler on The World According to Dick Cheney and Josh Braun on Submarine.
Daily Buzz: Sundance Episode 6
Today's podcast brings the heat with a fast-paced wrap-up of the best so far and the best yet to come at Sundance, plus the true story of the hunt for bin Laden in Greg Barker's doc Manhunt and Albert Maysles on his approach to nonfiction filmmaking and his new short The Secret of Trees.


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Categories > Celebrities > My Chemical Romance > Restating the obvious, Killing what's left
'I'm sure I can top that'1 Reviews
Ben took the crumpled paper that was clutched in his hand. He sat on the kitchen table, pushing the grocery bags to one side. He set the paper on the table and passed his passed his big hand on top of it, flattening the wrinkles in it.
He stared at Alice's almost illegibly tight handwriting in pink ink that covered the black heart-coated piece of notebook paper. As he read he could hear Alice's voice in his head, the way she would pronounce every word, the short pauses and the longer ones she'd make. The way she would emphasize one word, and the slower fashion in which she had gotten to articulate certain words...
"You know, I never thought it'd be so difficult giving her up.
As soon as I was in labour I was thinking something like 'I don't give a shit, they can even kill her, I really don't care'.
I'm not sure that's what I really felt...
Hell, who am I kidding?
I was pretty damn sure that was exactly how I /wasn't/ feeling. I was kidding myself.
...Just as I tried to fool myself a moment before.
But after I saw her face I was in love.
I mean, she was beautiful.
I never thought something covered in several and equally disgusting types of body fluids could be so flawless.
But she was.
And after I saw her I knew how I was going to name her.
Elizabeth just floated instantly into my disturbed mind.
But I can't turn back now; I already signed all of those shitty papers. Changing my mind is worth a lot of money, money I don't have access to right now...
'Cause I'm not stupid.
I know that no one will give a recovering drug addict access to such eye-widening amounts of money. They would all think it would be for drugs...and if I said it is to have my daughter back they'd say 'no' anyway, tell me that I'm not fit to care for a daughter.
They'd give me the same brainwashing talk they gave me that time, the one that influenced in my decision to give her up.
Good Lord, why did I give her up?
Bert sat in the couch, uncomfortably looking at his feet.
"So..." He said, shifting his feet from their position.
"I really liked the new cd, by the way" Kamz said, smiling at Bert. He raised his eyes to meet hers and returned the smile.
"You know what my favourite part is in the whole cd? At the end of 'Smother me'! 'Quesa....dilla. Quesadilla' I loved that. So goddamn hilarious." She commented, Bert laughing alongside her.
"yeah, I love that too" Bert said. They're laugh stopped as they heard the doorbell ring. Kamz sat straight instantly and lifted herself from her seat, "I'll open it..." She uttered, almost dramatically. Bert raised an eyebrow quizzically as she went to the door and greeted Gerard. As soon as Bert heard Gerard's swift Jersey accent his head flipped to where the door was placed. He stared hard their way and his jaw almost dropped as Gerard entered the living room.
They both shrugged when their eyes met, brows furrowing and teeth clenching instantly. The brutal exchange of words was about to start but in that moment Ben entered the room.
"Hey guys... "He said rather awkwardly. "Please sit down..." He said, as he followed his own request. "I'm fine" They said in unison, giving each other nasty glares.
"I do think it's better if you sit down..."Kamz said reassuringly. They reluctantly accepted and sat as far apart from each other on the couch. Ben's mouth was about to open when the doorbell rang once more.
"Oh shit, I didn't think they'd make it..." Pete said, going to the door.
"More people?" Bert mumbled under his breath. Gerard grunted: he hated when Bert voiced his own thoughts out loud.
Daniel and Allison walked in. They didn't seem too surprised of staring at Bert and Gerard sitting on the couch at opposing ends. Daniel groaned and sat by Pete's side on one of the cushioned wooden kitchen chairs, dragging one for Allison as well.
"What the hell son?" Bert snapped incredulously.
"If you didn't insist on keeping shit away from me I wouldn't need to skip school..." He replied curtly, arranging the cushion on top of the chair before sitting.
"You /skipped/?!" Bert hollered back.
"I really don't think that's what you should be worrying about, Bert" Kamz said, leaning forward and placing a hand on top of Bert's trying her best to sound comprehensive.
"Oh really, what's more important than having my son lie to me, skip school and somehow drag his girlfriend's butt (without her mother's consent, I'm sure) and his own from Utah to /Vegas/? Oh God, Daniel, please tell me you didn't take Jepha's joke seriously and you two prostituted your way over here!" Bert cried in preoccupation turning to Daniel very seriously indeed. The other tried to muffle out laughs with their hands.
"Of course not..." Daniel denied the statement with a lopsided grin on his face.
"I'm sure I can top that..." Ben declare slowly, taking a huge gulp before saying "Honey, you can come in now"


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UK harvested its first hemp crop in decades on Sept. 23.
UKAg faculty will participate in UK Gaines Center's Lafayette Seminar in Public Issues, which will address three aspects of the food issue.
High cattle prices and ample high-quality forage provide a unique opportunity.
An insect ecology lab at UK has three articles published in a journal that highlighted the latest research on unraveling food webs in nature.
Could what's on the ground prevent bird strikes in the air? UK Ag researchers think it's a good possibility.
UK researchers are working with scientists in Brazil to stop the spread of coffee ringspot virus.
UK will offer seminars in 14 Kentucky locations. They are designed for professional tax preparers with at least one year of tax preparation experience.
Wednesday's event will be an eye-opening experience for some UK students.
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Home > Post > Post 11 > Post 11 News Release > News Release
News Release
TPR Lloyd Cochran
Public Affairs Officer
Kentucky State Police
Post 11, London
(606) 878-6622
Click here to e-mail TPR Lloyd Cochran
Arson Investigation in McCreary County
Date of News Release: 03/26/2014
(LONDON, KY.) - On Friday, August 30, 2013 at approximately 10:37 PM the Kentucky State Police, Post 11 London, received a report of a structure fire on Water Plant RD in the Stearns community of McCreary County.
Upon arrival, KSP Post 11 Arson Investigator Detective Brian Lewis determined that Whitley City fire fighter Arlie "Pooh" Hill III, 37, of Stearns was severely injured in the fire after going into the burning residence to see if anyone was inside.
After being hospitalized for nearly two (2) months Lieutenant Hill died as a result of the injuries he sustained in the fire.
After an 8 month long investigation Detective Lewis has determined the cause of the fire to be arson.
At this time Detective Lewis is still following up on leads. Anyone with any information in reference to this investigation is asked to contact the Kentucky State Police.
Anyone with information on any suspicious fire can call the Arson Hotline at 1-800-27-ARSON (1-800-272-7766) or the Kentucky State Police at 1-606-878-6622.


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Calorie-cutting kitchen gear
No gadget will lose the weight for you—but the right kitchen gear can make losing pounds a whole lot easier. (Not to mention more fun!) Check out these six tools that any health-conscious cook will love.
More: 25 delicious detox dishes
--By Amanda First
Slimware plates
These make portion control simple. Each flower represents a nutritionist-approved portion of veggies (left), protein (center) or carbohydrates (right). ($37.50 for a set of 4, slimware.com )
Savora oil mister
Lighten up your salads and sautés by spritzing on heart-healthy olive oil with this mister ($25 each, savorastyle.com ). (Don't limit your oil to the kitchen! Find out which oil can erase dark skin spots naturally.)
The Dreamfarm Vebo
You'll cook veggies more often once you have this all-in-one steamer, boiler and strainer that bends to fit any pot ($30, dreamfarm.com).
More: Dodge pesticide-laden produce with our guide to the 12 fruits and veggies you must buy organic.
The Perfect Portions food scale
This scale calculates nutritional info based on weight and displays it in a "Nutrition Facts" box like the one you're used to seeing on packaged goods ($50, amazon.com).
Cuisipro Herb Keeper
Diet-friendly fresh herbs last longer in the refrigerator when you store them in the Cuisipro Herb Keeper ($21, cuisipro.com ).
Prepara volcano fillable ice pop molds
For a healthy ice-cream alternative, pour fresh juice into these easy-to-use molds ($10 for a set of 4, prepara.com). Can't wait? Blend up one of these 25 delectable detox smoothies.


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2012-09-12 02:00 - A glimpse into Norwegian artist Truls Espedal's creation process for the RIITIIR album artwork plus a narration by ENSLAVED vocalist/bassist Grutle Kjellson is now available for viewing here: http://www.youtube.com/watch?v=LNgLTl3PuVE
The twelfth studio installment by Norway's progressive extreme metallers ENSLAVED, "RIITIIR", is due out in Europe on September 28th. It was recorded in Bergen, Norway at Duper Studios, Earshot Studios, Solslottet Studios, and Peersonal Sound. At Fascination Street Studios in Örebro, Sweden, Jens Bogren handled mixing duties while Tony Lindgren handled the mastering. The team of producers includes ENSLAVED's very own Ivar Bjørnson, Grutle Kjellson & Herbrand Larsen, plus Iver Sandøy.
View the lyric video for "Thoughts Like Hammers" here: http://www.youtube.com/watch?v=Vmyth2ybwHQ
All editions of RIITIIR are now available for pre-order from the Nuclear Blast web shop: http://www.nuclearblast.de/suche/enslaved_riitiir
|Linked bands
ENSLAVED – Ivar Bjørnson to curate ...
2014-07-23 16:50 - ENSLAVED guitarist Ivar Bjørnson has been announced as one of the curators of Roadburn Festival 2015 alongside WARDRUNA's Einar Kvitrafn Selvik. As curators, both Ivar and ... Details
METAL HAMMER AWARDS – vote for your favour...
2013-04-18 03:00 - This year, Metal Hammer Germany will award their annual Metal Hammer Awards for the fifth time on Friday, September 13, at the "Kesselhaus" in Berlin, Germany, with live pe... Details
ENSLAVED – receive 7th Norwegian Spelleman...
2013-02-12 00:00 - NORWEGIAN progressive extreme metal band ENSLAVED have just received word of their nomination for the 2012 Spellemann Award in the category "Best Metal Album" with their mo... Details
ENSLAVED – "RIITIIR" out now!
2012-09-28 02:00 - Norwegian progressive extreme metal band ENSLAVED have just released their brand new masterpiece "RIITIIR" today.
2012-09-27 00:00 - The following is the seventh of eight installments where rhythm guitarist/songwriter/lyricist Ivar Bjørnson and bassist/vocalist/lyricist Grutle Kjellson of the Norwegian ... Details
ENSLAVED – track-by-track commentary ...
2012-09-24 02:00 - In the sixth of eight installments, ENSLAVED bassist/vocalist/lyricist Grutle Kjellson and rhythm guitarist/songwriter/lyricist Ivar Bjørnson offer song commentaries on ... Details
ENSLAVED – track-by-track commentary ...
2012-09-20 01:00 - In the fifth of eight installments, ENSLAVED bassist/vocalist/lyricist Grutle Kjellson and rhythm guitarist/songwriter/lyricist Ivar Bjørnson offer song commentaries on their Details
2012-09-19 02:00 - Ivar Bjørnson, songwriter, rhythm guitarist, and lyricist for Norway's progressive extreme metal band ENSLAVED, will be participating in a live Twitter Q&A session today at .. Details
ENSLAVED – Track by track commentary, part 4
2012-09-18 05:00 - The following is the fourth of eight installments where bassist/vocalist/lyricist Grutle Kjellson and rhythm guitarist/songwriter/lyricist Ivar Bjørnson of the Norwegian ... Details
ENSLAVED - exclusive stream of the new ...
2012-09-17 00:00 - From 01.00 pm CET on, you will be able to stream the brandnew ENSLAVED track "Veilburner" exclusivly from the hompage of the German Metal Hammer magazine.


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Reader Comments (Page 1 of 1)
NOT DISAPPOINTED!?!? are you kidding me? Theres like two things that are kinda cool that they did for us, otherwise we got a swift kick in the yatch. REMOVE BLACKOUT?! I'm and big pvper and pve-r, when the proc is allowed on trash etc. its usefull as hell, and its the ONLY "chance" of actually killing someone if ur a shadow priest. There's too many outs for other classes to get away from you or shut you down. On top of that, how the heck can you say that the shadow form change is that great. YAY I CAN CRIT ON DOTS ... wait .. does that really matter considering I only have two of them? Id rather hit for an extra couple hundred damage stacked onto my crit for my mindblast sw:death combo than have dots criting like crazy. (ps, bring back shorter sw:d CD)
yes shadow fiend is ok, but if im not mistaken it looks like its nerfed to? reduced speed to player speed? is that my player speed or the pally/dk thats running away from me?
Dispersion is really the only good change i can see here, even from looking at some of the holy/disc changes.
really disappointed, though they might have SLIGHTLY helped out pve shadow priests, There's really no reason to play one anymore with the current changes. Might as well roll a lock... we cant mana battery, and our ve is helping ... kinda ... if you look at it like it was a mini totem. What does this make my current role as a shadow priest? Cast 4 spells in sequence and occasionally shield people that the healers cant get to ...
gg blizz >
Yes i totaly agree with you. But it depends on what stat youre going on. Ive got a spreist myself hes got 420 haste 2100 sp ubuffed. These changes are good for me. If you are a shadow preist with lets say 20%-25% crit and really low haste this is a nerf but look atn the bright side now yoou have gather mote haste and sp gear ;D


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Indian gaming casinos are found throughout the country in almost every county. Each tribe provides the land and setting for tribal gaming with a portion of the profits going back to the tribe. There are certain rules that apply to Indian gaming casinos that may not apply to Nevada casinos, like no alcohol while sitting at slot machines (spielautomaten). All spirits must be consumed in a bar area. Many of the casinos provide smoking and non smoking areas for gamblers so if you do not smoke you can enjoy your personal area while having fun. They offer some of the most technologically advanced versions of video blackjack or roulette in the nation. Most are decorated with a Native American theme and the gift shops offer beautiful art work from local tribal members. They have become some of the most beautiful casino resorts offering amenities like spas, golfing and fine dining. If you are lucky enough to have an Indian casino near you, it pays to make a visit and enjoy the sites, the sounds and the friendliness of the staff and patrons.
Milk crates have been around for very long now, they are good containers for the milk. But have you ever wondered what other possible benefits can they offer? The best they can do is finishing the mess created by tidbits in your house. For example the garage, children's rooms, dressing table etc. All you have to do is place these bins where you think they are needed the most; they are good to store tidbits. Placing one in a garage is a nice idea to store tools that may be otherwise found on the floor. Your little ones have color pencils and other small things all over their room? Provide them with the same mini bins to store the mess in. Throwing the milk crates away is not the best you can do when they can be used as such a wonderful containers. Managing little things becomes easier with them.
Looking and feeling great is every woman's priority. Clothing gives you this sense hence the need to have the right outer and inner apparel. Searching for the right bras can be a woman's nightmare. However, this does not have to be the case with Vanity fair bras. These are at their best. Vanity fair has been in the lingerie business for four decades. Consequently, they have the expertise to manufacture only quality bras for today's woman. In addition, your size is no issue to Vanity fair. There is a wide collection of all sizes. If you are petite or full figured you can be sure to get a perfect fit that provides you with complete coverage. Our staff at Vanity fair stores will assist you in taking your correct bust measurements. This will ensure that you get the perfect support from our bras. Bras should not be boring because you wear them under your clothes. Hence, a wide range of colors and styles are availed to you to suit your taste and preference. Similarly, new arrivals come in everyday. At Vanity fair, you can choose bras that will give you confidence and poise as well as provide you with the elegance of a beauty queen.
Anyone that has never been to a casino may believe that these games are very difficult to make money playing. However, this is not the case when you have a game that you enjoy playing. Professionals are able to become successful simply because they find a passion for something that they enjoy and then use it in order to make as much money as possible. This is now something that you will be able to do when joining an online casino. One difference that you will notice when playing online is the ability to connect and enjoy a game whenever you have free time during the night or day. More time available for playing means that you will be able to practice and become the best player possible. In order to do this, you will need to find a game that you have an interest in playing. The online game selection is much larger than you would find at a traditional casino. However, most games enjoy roulette blackjack and slot machines (gokkasten), these are some of the easiest games out.
The next time you visit a casino, head straight for the roulette wheel and put $100 down on number 23. You might think that would be a crazy bet and a quick way to lose your money and you would be right. The secret to having fun and enjoying your time in a casino is not necessarily winning, but only losing what you can afford to lose. In the meantime, you can spend several hours or longer playing the slot machines (gokkasten), blackjack or any of your other favorite games by simply sticking to a sound money management plan. Gambling should be thought of as entertainment and not as a way to make some quick money. While you can always get lucky and hit a jackpot with the first quarter or dollar you feed into a slot machine, most people wind up losing more than what they brought with them. So, in order to play for 3 hours, divide your bankroll up into 3 separate piles of money. Only play with 1 pile per hour. That way, you will be assured of making it 3 hours with some money in your pocket. If you win, separate that money and you will have something to take home when you are done gambling.
If you are wondering what kinds of gambling you can do at a casino maybe this will help. One of the things that you can do is try the slot machines. It doesn't cost that much money to play, just a few coins. This is a game of chance and the object is to win money from the machines. The second thing you could try is roulette. In this game the player may place bets on a single number or multiple numbers, on the red or black colors, or if you think the number will be odd or even. To find out what the winning number and color is the croupier spins the wheel one direction then spins a ball in the opposite direction around a track running around the wheel. Last but not least you could try your hand at blackjack. In this game you compare cards between a player and dealer and are played with one or more French decks of fifty two cards. So if you are interested in trying any of these gambling games out you can find them easily at a casino.
Anyone that has ever played slot machines knows how easy it can be to make money at a casino. However, this is typically very limited as a result of very few game being available in a traditional casino. A limited selection of tables can only place limits on the way that you are able to make the largest amount of available profit. However, joining an online casino would allow you to get rid of these limits while enjoying a much larger potential for profits. Playing games such as roulette and blackjack do not require a lot of skill. In fact, these can become easier by simply making sure that you are playing them on a daily basis. Making money from these games is one of the easiest things that you will ever do. However, if none of these games are exactly what you are looking for, slot machines can help even the most inexperienced casino player to begin enjoying cash profits. Join an online casino today and begin playing games that will allow you to start making money today.
One important factor that will determine how successful you are when visiting a casino is the amount of time available for playing games. An online casino experience will allow you to enjoy any games that you would like without ever having to worry about having a limited amount of time. One of the problems that people experience at a traditional casino is very long lines. When you spend most of your time waiting for a turn, this will place limits on the amount of profit that is possible during an average visit. However, playing online would allow you to play all of your favorite games without wasting time in play. Additionally, online gaming will offer a larger variety of games including blackjack, roulette and slot machines. These games are some of the most popular choices of players that have a limited amount of experience playing in a casino setting. The important thing to focus on when choosing an online casino is the amount of games that are available for you to play without wasting any time.
Warners bras provide great comfort and support through a range of designs and styles. Each design is carefully made to fit a woman's every need all through the day. Some of the most important features of Warners bras are their versatility, comfort, shape, and support, to name only a few. Warners bras come in a variety of designs such as Warners Elements of Bliss2, wire-free bra, invisible bliss wire-free front closure and more. These bras have been designed to give support, comfort, and seamless look in the best possible manner. Made with 100 percent cotton, these bras can be worn all day long with ease. If you think that these Warners bras would be costly then you are absolutely wrong – you can buy these bras at affordable prices. Visit any reliable online shop and buy these bras in just few mouse clicks. So, order now and feel the difference.
Kasino lovers greatly enjoy placing bets on gaming machines and playing online casino games with their gullible opponents. Gaming in casinos is legendary and it cannot be replaced by any alternative entertainment activities. Online casinos like Harry casino is slowly gaining ground as a gaming option where you can play without even involving the use real money, but to accumulate points for use on virtual slot machines.
You can download these games from the Internet prior to playing. It will take a while to master all the keys for operating and navigating through the game before you can play perfectly and enjoy it fully. Casino games can be broadly classified into three categories namely; 1. Simulated auto racing 2. Number ticketing games like Keno 3. Electronic gaming devices and table games All these games must be authorized and approved by the respective legislative bodies from the website country of origin. For entertainment purposes, you can play using simulated machines which work in the same way as real machines.


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Cobb Salad
James Carrier
Notes: Apple wood-smoked bacon adds especially rich flavor to this salad. Use leftover cooked chicken or buy roast chicken from a deli. Choose a pungent blue cheese such as Oregon blue, Roquefort, or gorgonzola.
Yield: Makes 4 to 6 main-dish servings
More From Sunset
Nutritional Information
Amount per serving
- Calories: 458
- Calories from fat: 71%
- Protein: 25g
- Fat: 36g
- Saturated fat: 10g
- Carbohydrate: 12g
- Fiber: 3.5g
- Sodium: 768mg
- Cholesterol: 129mg
- 1 pound sliced bacon (see notes), coarsely chopped
- 1/3 cup extra-virgin olive oil
- 1/4 cup tarragon-flavor vinegar
- 1 tablespoon Dijon mustard
- 1 tablespoon minced shallot
- About 1/2 teaspoon fresh-ground pepper
- About 1/4 teaspoon salt
- 1 quart lightly packed watercress sprigs (4 oz.), rinsed and crisped
- 5 quarts finely shredded lettuce (use half butter lettuce and half iceberg or all iceberg)
- 2 firm-ripe tomatoes (2/3 lb. total), rinsed, cored, and chopped
- 1 1/2 cups thinly sliced skinned cooked chicken (7 oz.; see notes)
- 2/3 cup crumbled blue cheese (3 oz.; see notes)
- 2 hard-cooked large eggs, shelled and chopped
- 1 firm-ripe avocado (1/2 lb.), halved, pitted, peeled, and thinly sliced crosswise
- 1. In a 10- to 12-inch frying pan over medium-high heat, stir bacon often until browned and crisp, 10 to 15 minutes; spoon out and discard fat in pan as it accumulates. With a slotted spoon, transfer bacon to towels to drain; discard remaining fat in pan.
- 2. In a 1-cup glass measure or small bowl, mix olive oil, vinegar, mustard, shallot, 1/2 teaspoon pepper, and 1/4 teaspoon salt.
- 3. Set aside 4 to 6 watercress sprigs; coarsely chop remaining sprigs. In a large bowl, combine chopped watercress and lettuce. Add all but 2 tablespoons dressing and mix gently to coat.
- 4. Arrange equal portions of lettuce mixture in wide, shallow bowls. On each, in pie-shaped wedges, arrange equal portions of bacon, tomatoes, chicken, blue cheese, eggs, and avocado.
- 5. Spoon remaining dressing evenly over toppings. Garnish salads with reserved watercress sprigs. Add salt and pepper to taste.
My Notes
Only you will be able to view, print, and edit this note.Add Note
Cobb Salad Recipe at a Glance
- COURSE: Main Dishes, Salads
- CUISINE: American, California
- MAIN INGREDIENT: Pork, Vegetables, Poultry
- PUBLICATION: Sunset
More Recipes Like This
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Recipe adapted from Betty Crocker's Cookie Book. Read more about these at Bake or Break.
|Line a 9″ x 9″ x 2″ pan with aluminum foil. Melt butter and chocolate in a medium saucepan over low heat, stirring frequently. Remove from heat. Stir in crumbs, nuts, sugar, water, and vanilla. Press mixture into bottom of pan. Refrigerate.
|Mix powdered sugar, butter, milk, and vanilla. Spread over crust. Refrigerate for 15 minutes.Melt chocolate and drizzle over filling. Refrigerate for about 2 hours.Remove from pan, using foil to lift. Cut into squares.Store covered in the refrigerator.


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Bette-B Bauer will read from her book Inscapes which is a remarkable memoir about one woman's determination to follow her desire for a life of spiritual freedom that leads her from Oregon to San Francisco, to Paris and beyond. The author's journey of transformation, from solitary alienation to a sense of belonging in the world, is insightful, funny and moving.
Bauer's exploration of the dynamic influences of "place" offers a powerful glimpse into her mind and spirit. Each new home that she makes for herself— whether it be in Oregon, San Francisco, Paris, the Virgin Islands, Mexico, Baton Rouge, or the High Plains—brings the author closer to understanding the intimate connection to the natural world that has shaped much of her inner life.
Upcoming Events
- Poetry Reading by Chun Yu
- Saturday, September 27, 2014Chinatown/Him Mark Lai, Chinatown Meeting Room
- Authentic Happiness in Seven Emails
- Wednesday, October 8, 2014Parkside, Parkside Children's Area
- The Public Library: A Photographic Essay
- Saturday, October 11, 2014Noe Valley/Sally Brunn, Noe Valley Meeting Room


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With BMW preparing its new Project i city car, we would expect Smart to react and provide us with a new model of their own. Enter the new Forfour model for 2014. The new model will be built along with Smart's new partners, Renault and Nissan. Fortunately, we wo n;t have to wait that long for a new Smart ,model. The third-generation Fortwo will be revealed in 2012.
The 2014 Forfour will be built on a lengthened version of the Fortwo platform, the same one used for the next Twingo. The Fourfour will be a rear-wheel-drive model, measuring 3500mm in length and 1550mm in height.
Under the hood there will be a new range of four-cylinder petrol and diesel engines, ranging from 1.2 to 1.8 liters. This new direct-injection petrol and common-rail diesel units will be used into a wide range of compact Mercedes , Nissan, Renault and Smart models. In both Smart s, the engines will be mated to a dual-clutch gearbox and will be offered in hybrid and plug-in electric drivetrain options.
These cars look kind of cool , but seem completely irrelevant in the car world. It seems that people should just start walking to places instead of taking these itty bitty cars out. We are not even convinced that these cars can be at all comnfortable.


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New abrasion- and stain-resistant ribbon edged thermal fused laminate over 1-1/2" thick solid core high-density particleboard. For use in a "U" or "L" workstation as a computing or conferencing space. Cord management grommet. Meets or exceeds ANSI/BIFMA standards. Top Color/Finish: Mahogany; Width: 72 in; Maximum Depth: 42 in; Height: 29 1/2 in.
Shipping Weight: 176 lbs.


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Springville World Folkfest
Photos courtesy of Springville World Folkfest
Click on any image to zoom in
|Country and Region
|United States — Utah
|Type of Festival
|Dance, Music
|Location of Festival
|Springville, Utah, USA
|Festival Contact Information
Springville World Folkfest
|Festival Description
The festival of folk dance and music was established in 1986 when it presented its first event. Since that first edition the festival has become an annual event. The festival brings together national and international dancers and musicians to perform. Families in the area host the artists with many returning for visits years later, and likewise dancers host their host familes in their own homes. The aim is to create an event where cultures are shared and friendships are established. Participants wear their colorful, traditional costumes making for a lively and colorful atmosphere.
|Festival Dates
|July 28 - August 2, 2014
|Festival Links
Other Sources:
Want more? Click on a color — travel and explore.
KadmusArts on Facebook:
- Like KadmusArts on Facebook — we are your gateway to interact with the global community of festival fans, artist and organizers. Please share your comments and experiences in regard to this festival at http://www.facebook.com/pages/KadmusArts/17962154811
Start or join a conversation about this festival in the Forum.


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Next, you'll be asked to connect with Twitter. Rest assured, we will never send a tweet from your account
without your permission.
We will send you an email with an invite soon.
Big Data + Social + CRM + Sourciing: Futurestep : Futurecasting - Futurestep Good stuff from @davemendoza
Excited to present at this action packed 1-day workshop! Sourcing and Recruiting Social —
See what's Trending Now for @peopleshark
Follow @peopleshark on Twitter


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Text Only | SAMHSA News Home
By Deborah Goodman
Thirty years of armed conflicts and a brutal dictatorship have eroded
the health of the people of Iraq and devastated their system of
health care. Understaffed, lacking supplies, and with ongoing concerns
for their own safety, Iraqi doctors and other health care personnel
are attempting to deal with enormous needs.
U.S. Secretary of Health and Human Services Tommy G. Thompson traveled
to Iraq at the end of February accompanied by a group of senior
Federal health care officials that included SAMHSA Administrator
Charles G. Curie, M.A., A.C.S.W. Their mission? To explore how the
United States can help rebuild the health care delivery system in
Iraq and restore the health of the Iraqi people.
Using the analogy of the U.S. Marshall Plan in rebuilding Europe
after World War II, Secretary Thompson said, "Because our health,
our economies, and our humanitarian values have become truly global
in nature, our responses must likewise be global in nature."
Six months prior to the trip, Secretary Thompson and other Federal
officials met in the United States with the Iraqi Minister
of Health, Khudair Abbas, M.D., and the senior advisor for health
to the Coalition Provisional Authority, James K. Haveman, M.S.W.
At the meeting, Dr. Abbas and
Mr. Haveman identified the three areas most in need of rebuilding
within the health care system: surveillance of infectious diseases,
oncology, and mental health. As a result, Mr. Curie served as part
of the visiting team.
In Baghdad, the team visited the Ministry of Health and the Al
Mansour hospital, as well as the Al Alwiya women's clinic.
Iraq's ancient history is distinguished. Often called the
"Cradle of Civilization," Iraq (Mesopotamia) was the site
of the world's first constitutional system and a center for
the study of medicine, science, philosophy, and the arts. The world's
first psychiatric hospital was built in Baghdad in 753 A.D.
Today, in addition to the lack of electricity, fuel, and safe drinking
water, many hospitals lack basic equipment and supplies. In a country
of 25 million people, there are fewer than 100 psychiatrists, according
to a report from the World Health Organization. There are no clinical
psychologists and very few social workers. Services and psychiatric
medications for mental health treatment are also scarce.
The country lacks community mental health services, and the country's
only long-term care hospital for people with serious mental illnesses
was looted and vandalized near the end of major combat in April
2003. Many of the patients ran away and are still missing.
Ordinary Iraqi citizens have been traumatized by war and debilitated
by years of living under an omnipresent, repressive dictatorship
with constant surveillance and where a chance remark or spontaneous
action could result in punishment or imprisonment.
« See
Cover Page: Across Borders: Reaching Out to Iraq
See AlsoArticle
Continued: Part 2 »
Also Related ContentFrom the Administrator:
Mental Health In Iraq »
See AlsoNext
Article »
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SAMHSA Announces Funding Opportunities
Manuals Guide Teen Marijuana Use Treatment
President's National Drug Control Strategy Includes Key Role for SAMHSA
Majority of Youth Obtain Marijuana from
People They Know
SAMHSA Releases Guide for Clergy
5 Million Parents Have Alcohol Problems
Rules Proposed for Workplace Drug Testing
SAMHSA Launches Two Major Efforts on Underage Drinking
Kit Links Service Providers to Resources for Older Adults
Disaster Assistance Center Offers Resources for Service Providers
Center Assists People with Substance Abuse and Child Welfare Issues
Recovery Month Celebrates 15th Year
Corrections & Clarifications
SAMHSA News


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Social Activities
ignatian society of boston college
Social Activities
The Ignatian Society's social programs seek to strengthen the bond between two great communities here at Boston College: the undergraduate students and the Jesuits. All BC students are welcome to participate in any and all events. Additionally, each Jesuit high school at Boston College has a representative in the Ignatian Society who keeps in contact with alumni. For a full list of representatives, click here.
Lunches with Jesuits
Weekdays throughout the semester
Get to know one of our many Jesuits here on campus over a nice lunch. Groups of 3-4 undergraduates meet with Jesuits at a Jesuit Community provided lunch. If you are interested in attending, contact Nina Touraji at email@example.com to sign up.
April Lunches with Jesuits
Tuesday, April 15th - Fr. Jeremy Clarke, S.J.
Thursday, April 24th - Fr. Casey Beaumier, S.J.
Tuesday, April 29th - Fr. James Bretzke, S.J.
February and March's Lunches with Jesuits
Friday, February 21st - Fr. Jeremy Clarke, S.J.
Thursday, February 27th - Fr. Casey Beaumier, S.J.
Monday, March 17th - Fr. James Bretzke, S.J.
Tuesday, March 25th - Fr. Bob Daly, S.J.
Monday, March 31st - Fr. Terrence Devino, S.J.


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One Button Destruction
by David Finley
Throw Pillow
Throw Pillow made from 100% spun polyester poplin fabric, a stylish statement that will liven up any room. Individually cut and sewn by hand, each pillow features a double-sided print and is finished with a concealed zipper for ease of care. Sold with or without faux down pillow insert.
Just push the button already...
- 176Promote
Thanks Denis! Megstuff, thank you, I'm thinking of posting a print here of the robot alone without the guy.


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The house is next to mine. The fence is mine. Nobody hurt.
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Printable View
The house is next to mine. The fence is mine. Nobody hurt.
Attachment 34736
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Glad to hear no-one was hurt. What was it like?
I was away. According to my wife, there was great rumbling sound and more wind than she saw in any of the four hurricanes that hit us a few years ago.
wild... we have nothing even resembling that here... nor earthquakes ... or dangerous animals... glad no-one got hurt :)
Tornadoes are rather rare in Florida, aren't they? I'm glad it appears to have been a weak one and nobody was hurt. I was working for a news broadcaster when that big one destroyed Greensburg, KS a couple of years ago; it's terrifying how much power those storms have and very fortunate that they tend to be limited in scope.
Florida gets more than their fair share of tornadoes unfortunately, including a rather spectacular storm system that wrought havoc on The Villages a few years back (my inlaws live up there). They aren't the kind of monster storms the midwest sees, but we are the lightning capital of the planet, so the conditions often get ripe for a twister. This one was mild in effect, if indeed it was a tornado and not just a brief squall of hurricane proportions, but it successfully took down every remaining sand pine in the neightborhood. Those trees weathered four consecutive hurricanes some years back.
I've lived in the mid west, most recently in Omaha, and I've witnessed the ominious power of the storms up there. Terrifying is right. I'll take my petulant, semi-tropical Florida any day :)
Glad you're cool, bro. I've dodged two twisters already this year...both before spring ever started.
Good to hear everyone's OK, we get tornadoes here in Ft. Wayne on occasion - I think 2 or 3 since I've lived here.


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SITKA — A trip to the grocery store can be a big ordeal for parents of children with disabilities.
"It can be challenging, because I have two other kids as well," said Jaime Bentley, whose middle child, Jema, has intractable epilepsy and cerebral palsy.
But the members of Girl Scout Troop 4140 are hoping to turn the trip to the store into a better experience for Jaime, Jema - and other children and parents - by purchasing three grocery shopping carts that can carry a person with disabilities weighing up to 200 pounds.
SITKA — After a delay of more than six decades, Mike Perensovich has received the prestigious Air Medal for the some 200 missions he flew as a flight engineer in the Berlin Airlift.
To say he's been patient would be an understatement.
"I waited for a while, but then I forgot about it," said the longtime Sitkan. "It wasn't until later years, and a friend said if I didn't press it, they would."
SITKA — Roofing volunteers or amateur archaeologists?
The workers on the Hames Center reroofing project thought of themselves as both last week after finding about 20 rusty iron balls, about one inch in diameter, mixed in with the river-run gravel weighting down the old roofing system.
SITKA — Kids taking the beatbox class at the Sitka Fine Arts Camp say you can start building your skills in this art form with "boots and cats."
Those are the first words they learned when they signed up for Austin Willacy's course at the middle school camp.
Beatboxing and vocal percussion are two related ways of making drum-like sounds with your mouth. It's not as easy as it looks, and the students are spending a lot of time on fundamentals, Willacy said.
SITKA — The incoming Sitka District ranger began his career with the U.S. Forest Service as a volunteer college student in a summer job improving fish habitat on Prince of Wales Island.
"I thought, this is the coolest thing ever," said Perry Edwards, who will move into the district ranger post on July 28. "I was a kid who played with water."
Soon afterward he found out about all the career opportunities available with the Forest Service all over the country. He was amazed. "You mean you can get paid to do this? You've got to be kidding me."
SITKA — The longest-serving sworn officer in the Sitka Police Department has worked under five different police chiefs and alongside some 150 different employees in the department.
On Monday, Lt. Barry Allen looked ready for retirement, dressed uncharacteristically in a sweatshirt and Carhartts for his final day on the job, handling mostly paperwork.
"After 25-plus years in, I'm looking for a change of pace in life," Allen said. He turned in his uniform Friday morning.
SITKA — Sitka Tribe of Alaska is one of 30 recipients of the 2014 W.K. Kellogg Foundation grants for family engagement projects, the foundation announced Thursday.
The STA grant is for $250,000 over three years for a project called "Wooch.een Yei Jigaxtoonei: Working Together to Increase Family Engagement." STA's application was among 1,000 received by the W.K. Kellogg Foundation.
SITKA — Students at Keet Gooshi Heen Elementary this week learned how to line up as either a "biscuit" or "butter."
They created a "spiral" and a "bagel."
And they held hands, sashayed and do-si-doed to the sound of modern and traditional music in the school music room as the visiting teacher Susan Michaels called the dances.
SITKA — A Sitka woman hopes to make a big sound — with the help of 100 small stringed instruments.
Jeannie Jay, a ukulele enthusiast and Katy Perry fan, is leading the charge to organize a performance of 100 ukulele strummers playing and singing the Katy Perry song "Firework," and capturing the event on video.
Jay's big dream is to attract Perry's attention, with the object of getting her interested enough to play a concert in Sitka. But at the very least, Jay hopes to inspire people in Sitka to pick up a uke, learn the song and be inspired by the words.
SITKA — The state has released a tsunami inundation map for Sitka, showing the estimated high-water mark in the event of a tsunami.
But Sitka Fire Chief Dave Miller said not to take the map as the final word on how high the water might rise in a tsunami.
"This tells us what the computer-generated study has found," said Miller, the city's emergency coordinator.
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