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Disney Princess Splashing Aquata
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2009 Player Previews - Carlos Marmol
Quick Links
- 2008 Season Recap: Carlos Marmol
- Nobody Expects the Dutch
- Closing is 80 Percent Mental, 40 Percent Physical
- Closers, Ex-Govs, and Caps. Oh my.
Can you believe the season is only a day away? I don't know about you, but this has been the longest spring ever. So, I have the honor of second to last player preview, unless we decided to look at the batboys or David Patton, if he makes the team. Until then, lets take a look at another bullpen arm.
Coming into this season, everybody thought (including me) that Carlos Marmol would be the closer for the Cubs. Well, a funny thing happened on the way to Marmol's accession to the top spot in the pen. After hedging about joining the World Baseball Classic, Marmol pitched for the Dominican, where he eventually blew a save against the Netherlands. The Netherlands? That's almost as bad as the Pirates losing to community college in Spring Training (which did happen).
The one thing that I love about Lou Pinella is that he wants competition in Spring Training. For the most part, it works. Guys like Ryan Theriot and Mike Fontenot are living proof. This year he opened up the closer's role, and Kevin Gregg stepped up to challenge Marmol. With WBC and a spotty spring, Lou chose Gregg, who hasn't given up a run all spring. Marmol's been wild this spring, hitting five and walking two. That's led to his 4.35 ERA. We can only hope that the Netherlands incident hasn't carried over to the Cubs.
Marmol has been a workhorse for two seasons, and I'm convinced that his exploits are a major reason the Cubs are two time NL Central Division Champions. In the past two seasons, Marmol has thrown 156 2/3 innings, while striking out 210 with his slider. There are times where he relies on the slider too much, and it has got him in trouble at times when he couldn't locate his fastball. Last season, he only allowed 40 hits in 87 1/3 innings, which translates into an .0927 WHIP. It just doesn't get much better than that.
Still, with all those numbers, I'm glad Lou gave the closer spot to Gregg. Now, he can continue to use Marmol in the situations where the Cubs need a strikeout or two innings of relief. That being said, Lou does need to balance him out a little bit, because he has looked less than sharp at times. The Cubs have a serious problem, and little depth if Marmol isn't lights out again this season, but I'm not worried (well, at least not yet).

subset: commoncrawl


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- joy faber
- Moriarty, NM
- United States
recycling artist, Read "Write" Literacy of Torrance County
This conversation is closed.
Do you think marriage, as a social commitment device, still works? Or did it ever work?
I'd like to see what people think of marriage as a social commitment device.
Topics: commitment divorce marriage
Showing single comment thread. View the full conversation.
Thomas Brucia 10+Dec 27 2011: In some respects marriage seems to act as a reflecting mirror of other societal 'contracts'.
It used to be that employers took care of their employees and that these in turn tried to protect the interests of 'the company'. (I remember my father's insistence we buy American Cyanamid products like Breck shampoo or Lederle drugs since they were 'company products'. The way one rose in an 'old style corporation' was by tying oneself to a mentor. He would look after your interests and you looked after his. There was therefore 'commitment to the team'. (Side note: This has survived in Japan, though there too it's a waning view).
In the U.S. many people approach marriage just as they do the 'job market'. You find an employer who offers a good 'benefit package'. If he finds you inconvenient or finds someone more to his liking, you get a few hours to 'clear out your desk'. If there was no written agreement for a 'termination package', you head out the door to find a new employer. Likewise, if you find yourself a new job that pays better, you arrange for a starting date, and then -- if you feel like it -- you tell your existing employer you found 'a better deal.' If there are uncompleted projects, you leave the mess for him to clean up.
Likewise (many marriages). It's all about 'shopping for a better deal' or 'getting rid of deadwood'. I have no idea how the 'new model' for both marriage and for work relationships interrelate, but I suspect they're both the result of more options, optimism that one can 'improve' one's station in life, a disregard for the interests/feelings of others, and a basically self-centered and individualistic approach to 'the world'. It's just more and more Gesellschaft and less and less Gemeinschaft.
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March 2012 Cookbook of the Month: The Olive and the Caper
- L.Nightshade Feb 29, 2012 09:15 PM
Welcome to the March 2012 Cookbook of the Month! This month we will be cooking from The Olive and the Caper: Adventures in Greek Cooking, by Susanna Hoffman.
If you haven't ever participated in the Cookbook of the Month discussion, we hope you'll give us a try in March. We have a lot of fun, and we learn from each other's experiences. The basics of COTM, and the archive of past books, can be found here:
If you are curious about the selection process, and the accompanying discussion, the nominating thread is here:
and the voting thread is here:
Also, there is some discussion to be found in the announcement thread here:
I've divided the book into six sections for reporting on recipes. I've tried to keep the divisions in the order they appear in the book, but divided so that they each have a roughly similar number of recipes. (For example, Sauces and Toppings is coupled with Birds, and Wild Game, because none of those three categories had a great number of recipes.) I hope this works out for reporting. The page numbers are for the US 2004 edition.
Here are the links to the reporting threads:
Drinks; Small Dishes; Savory Pies (pages 4 - 113)
Breads; Soups; Salads (pages 118 -213)
Eggs; Sustaining Grains; Vegetable Parade (pages 214 - 321)
Fish and Shellfish; Meat (pages 322 - 405)
Birds; Wild Game; Sauces and Toppings (pages 406 - 487)
Fruit as Finale; Sweets (pages 488 - 563)
In addition to using the above threads to report on specific recipes, please feel free to use this thread for general impressions, menu ideas, ingredient sources, and links to online recipes.
The Chowhound Team has asked me to remind you that verbatim copying of recipes to the boards is a violation of the copyright of the original author. Posts with copied recipes will be removed.
Gosh, I really fell way behind during the Feb. COTM. I hope I don't do as badly this month. There are still quite a few Japanese recipes I want to cook and perhaps I'll be able to slip one in from time to time.
OTOH, I have singled out some intriguing recipes from this Greek book. The goat for one plus I see that I can use my clay pot for a few of the lamb recipes. From another cookbook I have, Mediterranean: Food of the Sun by Jacqueline Clark and Joanna Farrow, I noted 2 recipes: Kleftiko (lamb) and Afelia (pork) that I hope to find in The Olive and the Caper... or something similar. The recipes in this book seem different than the Kochilas book, The Glorious Foods of Greece.. Thanks to Lulusmom for the tip about seasoning.
Thank you, L. Nightshade. for coordinating everything seamlessly...!
re: Gio
Hi Gio,
Regarding clay-pot recipes--I found one that isn't listed as such in the index, but the recipe instructions say to cook in a clay pot--so that's what I did. The recipe is Beef with Kalamata Olives and 100 Cloves of Garlic, and I will post my review on the appropriate thread.
Yes, L Nightshade, the coordination you provided was really great.
Even though I won't be cooking from the COTM this month, I am still quite interested in each and every posting. (I cooked a little a few years ago from this book.)
I am posting just for a simple reason, to thank everyone for making cooking more exciting for me, and wanted specifically to say that I particularly like the page numbers after the sections. For some reason it was confusing to me to sift through the categories - pages identified: I like!
Edited to include - further thought:
By posting here now, this will bring up further postings into my personal threads - :-)
Woohoo! I can't believe it's March. I'm hoping to receive my book today. I'm also hoping to get at least a COTM recipe or two under my belt this month. I have very easy access to a greek grocery, so I'm hoping that it will be "easy" for me to participate this month. I'm a little worried about the confusing layout of the recipes everyone has been talking about, though. It seems even the smallest of inconveniences turn into giant barriers for me lately when it comes to COTM participation...
re: The Dairy Queen
Don't be worried about the page layout, TDQ. It really isn't as bad as it seems at first. Just take care moving from one column or page to the other, making sure you have the right recipe after the move...IYKWIM. That's the only thing I had to be careful of when I started reading the recipes. As for the other writings: stories, history, etc. I read them only if I'm interested at the moment and go back later if I think it's something I need to know about the recipe... I always read the header notes and tips, though.
re: The Dairy Queen
Hey TDQ, would that Greek grocery be Bill's Imported Foods, by any chance? I have very fond memories of Bill's when I lived in that neighborhood.
I hope you manage to participate too. I always enjoy your takes on recipes! (Heck, I hope *I* manage to participate as well. Haven't been doing much in recent months.)
re: Karen_Schaffer
Karen, yes! Bill's Imported Foods! http://www.billsimportedfood.com/ I'm always looking for an excuse to go there...
Gosh, I'm not sure if I knew you once lived in Minneapolis. Small world.
And, yes, let's hope we both find time to dive in this month.
re: The Dairy Queen
Yep, between 34th & 35th on Colfax. That was 15+ years ago, but I'm glad that Bill's is still around. Did you ever go to the butcher on Bryant and, hmm, 35th or 36th? They closed probably 20 years ago, but I still mourn their beef jerky. It was big chunks of real meat, the moistest, most delicious jerky I have ever eaten. A really great butcher shop in every respect. There was a fantastic old-fashioned hardware store next door, the kind of place that had everything needed to repair old houses, because they still had it in stock from when the houses were built. Ah, nostalgia. Now I'm making myself feel really old.
Anyhow, I picked up the book at the library today, sat in the parking lot to browse the recipes, then went to Trader Joe's to pick up what I needed. Success!
re: Karen_Schaffer
Unfortunately, no, that butcher would have been long closed by the time I moved to MN. I've been here less than a decade (although, surprisingly close to a decade, which boggles my mind because I still feel *new* here. Probably always will). Too bad the place closed, you could have posted about it in this MSP beef jerky thread http://chowhound.chow.com/topics/835955
I have my book now, too, and am planning my strategy. I still have high hopes even though early reports from the book aren't consistently spectacular. I have a convenient TJ's too (which is definitely new since you lived here!), but I'll go to Bill's first. ;-).
Thank you for the job well done, L.Nightshade. I thought your approach to the COTM process was a bit different and very effective. I really liked how your narrowed the selection to two books for voting. It was so much easier to choose between the two - than three and more. I also liked that you added page numbers to the sections that you divided the book into. I always find that there are too many reporting sections and maybe next time you'll choose to devote 150 pages to a section and maybe it won't make sense:) Congrats!
re: herby
Thanks herby, and everyone else for you kind comments! I really didn't try to do anything differently, just followed the footsteps of my able predecessors. The nominations narrowed naturally to two books, as they each had at least twice as many votes as the next runners up.
I know what you mean, herby, by the many reporting sections. Sometimes it feels like we are not cooking together. One month, some time ago, I found myself to be the only person reporting in one of the threads. It was lonely! On the other hand, in an active month, the threads can get long and unwieldy. Oh well, we can strive toward a happy medium.
re: L.Nightshade
Yes, great job L Nightshade!
re: jpr54_1
I intended to pick up my copy of the book yesterday but ran out of time. I'm hoping for today. In the meantime, there are a number of pages available through Google Books: http://books.google.com/books/about/T...
and there are these online recipes that BigSal posted in the announcement thread:
re: jpr54_1
Book arrived early this morning--
I will look it over an read preface, etc. and then go shopping Monday/Tuesday
Nice job on the thread organising, L. Nightshade. Just one teeny thing - would it be possible next time around to preface the threads with COTM as I find it much easier to locate them then. Thanks!
Am planning to make the beef stifado tonight - will let you know how it goes...
re: greedygirl
Agree! Brava to L. Nightshade for a very well-organized first month!
GG, I'm glad you were able to acquire this book!
re: greedygirl
greedygirl - I will keep that in mind for next month! I used last month as a reference, which didn't have COTM in the titles, but now when I look back, I see that most of the others do. I think last month was just a little different, as it was labeled "Japanese Month." So, my mistake!
re: L.Nightshade
I think lots have the month and maybe the year as well, which possibly helps with archive type stuff.
In other news. I am pleased to report that I had two big hits from the book tonight. Reports to follow in relevant threads...
re: greedygirl
Yes, that's what I was trying to say. I used last month as an example, but it was a little different from the others. When now that I've gone back to look at the others, they do have that information. Myself, I usually go to the index thread to find the chapter threads, but I can see it would be helpful to have the heading on each chapter thread, so I will do that next month.
re: L.Nightshade
I am so very sorry about that L Nightshade, totally my fault. Last month was a pretty difficult one to put together (especially without the books in front of me, and having a cold that whole week), and I just totally forgot to put in the whole COTM part of it. So the fault is definitely not yours, but mine.
re: LulusMom
It's really not a big problem, or a criticism - I didn't even realise how useful it was to have the COTM moniker until it wasn't there, ifyswim.
re: LulusMom
Oh please LulusMom! I didn't mean to blame you at all! I just didn't look at enough examples! The organization of Japanese Month looked pretty complex. I'm only hoping to live up to your great work.
re: L.Nightshade
That Japanese month was just *crazy* to organize. Don't worry, I didn't in any way take what you said as blame, I was just pointing out that I realized halfway through the month that I'd forgotten to put COTM, and now see that not asking to have it fixed was a mistake.
The good news is that all the sudden we're reading some really good reports on recipes from this book. I'm feeling a lot sunnier about it now.
re: L.Nightshade
I go to the index thread if I'm looking for threads to post reports in, but I like how seeing that COTM designation makes them jump out as I'm scrolling around the board, so it's easy to read along if I come upon them.
I also wanted to say that I like the note you added in the threads reminding people how useful it is to keep recipe reports together, and how to do so.
re: Caitlin McGrath
I see the nice people at Chowhound have fixed it for us. *applauds*
re: greedygirl
I sent them a request to change the titles, I didn't know if they would do it but they did! So everything is in order now, thanks to the CH Team!
re: jpr54_1
Excellent question. I'm sure it's very individual, but to me clear direction and predictable, consistent, delicious results are essential. In addition, for a cookbook like this, I do think authenticity would be important, although there might be those occasions where an ingredient isn't readily available in the U.S. and she'd want to remark on that, then offer an alternative. And I like it if the book has a little personality or charm, either by offering personal stories, or context for the recipe, etc.
re: jpr54_1
Boy, jpr54, that is a fascinating, and huge question! Very interesting to ruminate about one's own preferences. I want clearly-written, logically organized, easy-to-read and above all, interesting recipes! Don't have to be easy necessarily, because a little challenge in cooking can be fun! And if they are from a regional or ethnic cookbook, I want authenticity that can be achieved in my kitchen using (mostly) local resources! In other words, I want IT ALL!
Do I get it all? Sometimes, and that's what makes for a great COTM, to my mind. There have been some memorable ones, in my admittedly short 1 1/2 years on Chowhound,
I think this month's "The Olive and the Caper" is provoking some mixed reviews so far because it has flouted the easy-to-read (and follow) typographical rules in its recipes and layout. Some folks have found the seasonings and instructions to be off, as well. But on the authenticity-side, it is a winner, at least to a non-expert in Greek cuisine like me. I love the introductory notes and side-bars about Greek history, culture, and ingredients, and the recipes themselves are introducing me to new ideas and combinations: Beets and Turnips in Sweet Caper Butter, to name just one, not to mention Goat meat! Some of them are probably not going to happen, at least in my kitchen--Thyme-Fed Snails! Marinated Lamb's Liver!--but it's fun to read about them.
re: jpr54_1
This is such a great question, and as you can see, the answers are slightly varied, but pretty consistent. We all want recipes that are interesting and turn out as we hope they will. I think consistency is huge (I loved the Gourmet Today book - I knew that I needed to up the spicing some, but as long as I knew that, the book consistently gave me great meals). I want easy to read and follow instructions (but then here I think of the Italian Easy books, which I loved, but which often needed serious editing). Mostly I want to be able to make delicious food, and I love cooking with other people - eggs me on a bit, and makes it more fun.
re: jpr54_1
The very least I expect is an index which I can decipher.
I wonder how many of my owned cookbooks' index (indices) leave me scrolling through the pages just looking for the R's and then the food, then the next and the next tab, and no spaces between. I am totally irrated by this before I even get to reading the recipe.
re: jpr54_1
Very good question! I agree with most of the responses already. I would add that I like a "voice" in a cookbook as well. I like to hear the author's point of view and get a feel for why these particular recipes are chosen (authenticity, deliciousness, ease, health etc). Pictures are always nice to get you excited and I agree that a reliable and complete index is important!
This months selection is interesting. I am happy to start seeing glowing reports on the food. I think the amount of side information in this book is a little distracting, especially as some of it seems unrelated to the recipe to which is is attached. For me, the layout and lack of pictures has made it a little hard for me to get into this book. But I feel like that's the beuty of COTM. Reading about other people's success makes me much more excited to dive in.
My expectations are usually rather high, unfortunately. When I read a recipe I can pretty much determine what the end result might taste like, so when I cook it I'm disappointed when it doesn't come close to what I think it should given the various ingredients I chose it for in the first place. Authenticity is a good thing but sometimes not easily achieved on my part because of the necessity of substituting a few unavailable ingredients. Additionally, I love learning about new cuisines and sampling those flavors that evoke the cultures of different areas of the world to which I could never hope to travel. Lastly, a few really quick and easy recipes in the repertoire makes getting dinner ready on a busy weeknight a pleasure rather than a drudge.
re: Gio
Boy, everyone is so articulate about their POV as to what makes a good cookbook, I find myself with little to add. If I had to sum it up in one sentence I would say what I look for in a cookbook, or any book, is to be taken on a journey. It could be a journey around the corner or to a far away land, just as long as wherever I go charms or teaches me something.
I know a cookbook is a keeper if I read it cover to cover. It goes without saying for me that the recipes should work, and the info needs to be easily accessible, but beyond that, it needs to transport me someplace wonderful through my senses.
I am really enjoying this book. I haven't made that many recipes yet, but it is a fabulous read. I was always a bit of a Greek History buff and reveled in the myths. I am really enjoying the stories and sidebars. I think having the recipes feed from page to page is a bit distracting, but the page layout seems more user friendly once we get into the soup chapter.
I bought this on a whim and am glad that I did. I can't remember who first suggested this book, so whoever that is, thank you!
re: smtucker
I'm glad someone else loves the book, I suggested it a few months ago. I've had it for years and cooked from it but not recently. At this point I'm almost sorry I recommended it because it's hard to read a bunch of disparaging comments on a cookbook I love. Oh well, it's chow hound I shouldn't be surprised.
re: rasputina
Rasputina. I would hate to think you are regretting reccommending a book. I know I have been a bit skeptical of this book at times, but as I said above, I think this book illustrates the beauty of COTM. This is a book I would never have picked up and bought if left to my own devices, but now I have already made one meal for my family out of it and am looking forward to making more in the coming weeks.
I don't think any of the comments have been made in a mean spirit and are not meant to offend.
re: rasputina
I am enjoying the book and I have made several of the recipes.
I had not previously made any Greek dishes and I am happy I joined this group to experiment and experience them.
I also enjoy the authors comments, history and sidebars.
re: rasputina
I think early reports on this book were a little mixed, but it seems (to me anyway) that recent reports have been very favorable and that people are excited to cook from it! Sometimes it just takes a little time to get into the rhythm of particular book or author and a book can grow on you. I think people have learned with this book to feel free to tweak a little here or there to make the recipes fit your tastes. "Italian Easy" and "Italian Two Easy" were like that for me. Early on, I was really frustrated cooking from them because I thought the books were poorly edited (with bad measurement and missing steps and ingredients). Eventually, though, I realized I was still getting delicious results from the books, despite all my frustrations, and I ended up buying one of them. Sometimes you just have to give a book a chance.
Furthermore, not every recipe or book or author is for everyone. I don't think you should ever feel bad about recommending a book you love to the group. We always love the hidden gems.
re: The Dairy Queen
P.S. Isn't it funny how personal a cookbook can feel though? Sometimes an author can paint such a vivid picture that you're completely drawn in, which can make you feel that you are practically sitting in her kitchen.
re: rasputina
Oh Rasputina, I am very pleased that you recommended this book, because it has inspired such interesting commentary and I for one have learned a lot from people's posts. Plus I've learned so much from the book itself and am looking forward to learning more as the month progresses. (Maybe not marinated lamb's liver, but braised goat for sure!)
The fun of cooking from the COTMs is that I find myself introduced to books I might never have have picked off the shelf at the bookstore. And I would have been the poorer for having missed The Olive and the Caper.
re: rasputina
Rasputina, when I first started reading the book I did not like it a bit and very dissapointed to the point of wanting to return it. But instead I continue to read and made a dish which I did not like... I read others reviews and read some more of the book and made another dish, more successful this time. By now I have a list, not too long yet but a list never the less. Going shopping tonight a few things and will make a meal from the book for tomorrow when my Albanian friend is visiting. Albanian food is very influenced by Greece and my friend's mother makes very good Greek dishes (she lives in the southen Albania). All this to say thank you for introducing me to a cuisine that I am not familiar cooking, and a book that I would not have discovered in a million years! I even want to try a goat recipe:)
re: rasputina
I too am finding more and more recipes I want to try, and I have had two big successes, including my new go-to tzatziki recipe.
re: greedygirl
GG, did you try smtucker's tzatziki recipe? You ought to if you have not!
re: greedygirl
I did not put sourcream in mine since smtucker said that she only puts it in when company is coming but oil is essential in tzatziki, imo:) Her recipe also has pepper, sugar and larger quantity of vinegar. I am trying beet tzatziki from O&C tonight.
re: rasputina
Rasputina, I am a new COTM...new chowhounder for that matter (I had viewed it as a quick reference and only recently discovered what a great community it is)...
BUT, this is a book I would never, ever, have discovered on my own. I have not cooked a recipe from it yet, but as an avid cookbook reader for the last 30+ years, this is a great cookbook. It is interesting, different, and accessible! Considering it is a "foreign" cuisine for the most part, what more can one ask?
re: debojay
I am sad to say that my copy of The Olive and The Caper is due back at the library tomorrow (some other CH-er has put a hold on it so I can't renew it) and I have yet to make one thing out of the book. Oh, what to do, what to do!!!!
re: dkennedy
Copy recipes that others were successful with that sound tasty to you if you have a scanned or a printer. If not, we will happily paraphrase and maybe some are on-line.
re: herby
I have probably overlooked it, but I couldn't see any on-line recipe links. Here's one. If I missed the links, plz forgive. I'm a bit rusty, having been out of touch for the past few months.
re: dkennedy
Some of the pages of the book are available via googlebooks.
re: dkennedy
Here are some links for you. Hope you get a chance to cook from this book.
http://oldowls.wordpress.com/2010/04/... rave reviews from Allegra on this one
The chicken version which we enjoyed. http://cookinghabit.blogspot.com/2008...
Double Lemon Avgolemono Soup [Soupa Avgolemono], page 169
http://www.dailycamera.com/ci_13071909 smtucker highlighted this one for us.
Eggplant Salad City Style http://www.cookstr.com/recipes/eggpla...
Eggplant Salad Country Style http://www.cookstr.com/recipes/eggpla...
Taramasalata with Bread http://www.cookstr.com/recipes/tarama...
Taramasalata with Potato http://www.cookstr.com/recipes/tarama...
Taramasalata with Bread and Potato http://www.cookstr.com/recipes/tarama...
Grape Leaves Stuffed with Pine Nuts, Currants, and Golden Raisins http://www.cookstr.com/recipes/grape-...
Leek and potato pie http://tinyurl.com/6t52798
Warm greens http://tinyurl.com/88gnons
Roasted Lamb Shanks with Garlic and Thyme http://tinyurl.com/7lbh67t
re: BigSal
Here's the Tzatziki recipe...
re: Gio
Spinach Pilaf. (Tonight I'm making Hoffman's Shrimp variation)...
Spring Lamb Stew
re: Gio
Found another recipe :
Pork Gyros with Yogurt-Tomato Sauce, Red Onion, and Arugula
re: dkennedy
dkennedy, very late seeing this post, but I think I'm the other CHer with the hold on the book. I haven't even had time to pick it up from the library yet and my life has gone kind of haywire, so I'm unlikely to get to cooking from it this month.
I'd be happy to go over and release my hold on it tomorrow so you could get it out again. It's in the Silver Lake branch though, so not sure how long it would take to get back to you.
The nomination thread for the April COTM is now up and running (yes, already!)
It will soon be stickied, but until then, here is the link:
The moussaka recipe in Olive and Caper is fantastic. I do find all the side bars, and the layout of the book distracting though--just too much on each page. But I do enjoy the stories, and photographs of Greek life. This inspired me to get out the book and look through it again--there's a lot there.
I am visiting New Jersey from Southeast Florida.
I went to Fairway in Paramus,International Foods(Rt.#17S)-they both had good Greek ingredients.
Fairway had great olive oil.
mizithra cheese....anyone out there familiar with it? or did anyone else try some this month? in a burst of enthusiasm i bought some greek cheeses this month, including some semi-hard mizithra, in my life i've never encountered a saltier cheese. trying to decide what, if anything, to do with it. suggestions welcome!
re: qianning
Ha! I bought some too! It's salty, rubbery, and it doesn't melt! I don't know anything about the quality of what I found, as I have nothing to compare it to, but I wasn't a huge fan. I expected it to be more like firm feta, or ricotta salata, I guess. Disappointing!
re: L.Nightshade
my sentiments exactly....thanks for letting me know it doesn't melt, i hadn't tried that yet....i really thought it would be more like a ricotta salata too.
re: qianning
I made a half-hearted attempt at trying to find the "K" cheeses, as someone else called them, but ended up using the very much less salty feta we found at TJ's for everything.
re: qianning
Does it grate? Could you use it as a topping on a flatbread, for example? Perhaps the saltiness would compliment a more 'bland' cheese?
Another thought is using it in a bechamel where the creaminess of the milk could neutralize?
I have not, for various reasons, been able to get to my Greek market where I was planning to get some of these unknown-to-me cheeses. Wish I could be more helpful.
re: smtucker
I wonder if it would be possible to "debrine" the mizithra. That is, soak it in fresh water changed every so often...
re: smtucker
I don't know about qianning's cheese, but the cheese I got really would not melt, I doubt if it would have worked in a sauce. But I don't know if that is typical. I ended up slicing it thinly and using it in sandwiches with un-salted meats and vegetables. That worked out OK, but I wouldn't buy it again.
re: L.Nightshade
i tried it grated in a salad today, used only oil & vinegar as dressing, and the salad was still way too salty.
SMT, don't know which Greek market you had in mind, just so you know, I got this at Sophia's in Belmont.....my first time there (usually I prefer Athena in Brockton, but had absolutely no reason to be on the south shore this month)....anyway, I would assume they would have had the "good" stuff, and and at least for me the semi-dry mizithra has proven a live and learn experience.
And on a corollary, the manouri wasn't my favorite cheese either, but it was edible. The vlahortiri, on the other hand, we both kinda liked especially as fried cheese w/ that lemon caper dressing.
re: qianning
Sophia's was exactly where I meant to head. Guess I will skip the cheese then, but I do have to go there regularly for my taramsalata fix.
re: smtucker
Everyone's different, but I would suggest tasting first if possible.
I did use a tiny (1/2 oz?) amount of the mizithra grated onto a feta tart/quick flat bread/alevropita last night; cooked at the 500 degrees that this tart required and finely grated it did melt a bit, not sure it added anything, but having left all other salt out of the recipe it did ruin anything either.
re: qianning
I've not had this, but the use of mizithra that seems always to come up is a simple dish people love from the Old Spaghetti Factory chain of spaghetti with brown butter and mizithra. Ridiculously caloric, of course. Not that one would need a recipe because that, it seems, is literally all there is to it, but: http://www.cdkitchen.com/recipes/recs...
re: Caitlin McGrath
fairway had several Greek cheeses-I tried them all-
most were too salty for me-I am on low sodium d iet-
I did buy a small amt. of kasseri


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This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
02 January 2013
Fragments in the clinic: 2013 edition
5 comments:
- @BioDueDiligence said...
Great list - thanks for updating. Astex has one more drug AT13148, an AGC Kinase inhibitor starting phase 1 trials in oncology.
- January 05, 2013 6:52 PM
- Chris said...
Might be useful to have a link to this list in the sidebar?
- January 11, 2013 3:44 AM
- Dan Erlanson said...
Good idea Chris - this post now has a link on the sidebar for easier access.
Thanks BioDueDiligence for the tip on AT13148.
I just came across a selective Abbott Bcl-2 inhibitor, ABT-199, in Phase 1b:
- January 12, 2013 3:31 PM
- Dan Erlanson said...
Here's the press release for AT13148:
- January 17, 2013 5:58 PM
- Dan Erlanson said...
Vernalis and Servier recently announced that their BCL-2 inhibitor has entered Phase I:
- August 17, 2014 10:22 AM


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Cold City (Repairman Jack)by F Paul Wilson
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Cold City is the first of three Repairman Jack prequels, revealing the past of one of the most popular characters in contemporary dark fantasy: F. Paul Wilson's self-styled "fix-it" man who is no stranger to the macabre or the supernatural, hired by victimized people who have no one else to turn to.
We join Jack a few months after his arrival in New York City. He doesnt own a gun yet, though hes already connected with Abe. Soon hell meet Julio and the Mikulski brothers. He runs afoul of some Dominicans, winds up at the East Side Marriott the night Meir Kahane is shot, gets on the bad side of some Arabs, starts a hot affair, and disrupts the smuggling of preteen sex slaves. And thats just Book One.
"In Wilson's lively first in a projected trilogy of prequels to his Repairman Jack saga (Nightworld, etc.), Jack, newly arrived in Manhattan, begins honing the skills that will eventually make him a formidable urban mercenary who operates off the grid. Jack's talent for finding trouble is already well developed, as becomes clear when his job smuggling cigarettes runs him afoul of Arab jihadists, the mob, and a ring of sex slavers. Wilson expertly evokes Manhattan in all its gritty glory in the early '90s and introduces series regulars Abe Grossman, Jack's gunrunner and surrogate father, and Julio, the hard-working barkeep at Jack's preferred watering hole, the Spot. Though preachy in spots and devoid of the supernatural subtext that invigorates the later novels, this valentine to Jack's legion of fans still packs a wallop that whets the appetite for his next early adventure. Agent, Al Zuckerman, Writers House." Publishers Weekly Copyright PWxyz, LLC. All rights reserved.
The beginning of a new prequel trilogy, Repairman Jack: The Early Years
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Our health club offers a fantastic range of facilities for both hotel guests and local members.
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Work out in the gym, take an exercise class or simply luxuriate in a sauna at The Legacy Farnham Hog's Back Hotel.
Take a revitalising swim in our heated indoor pool while your children splash in the small kids' pool area. Afterwards relax with a visit to the steam room or bubbling spa bath.
Active guests enjoy working out in the gym at The Legacy Farnham Hog's Back Hotel, with its weights and cardio machines. Wind down and tone up in our Pilates classes. Energetic lengths or a gentle dip in our heated indoor pool end a busy day perfectly. Soothe aching muscles with a visit to the steam room or Finnish sauna, or indulge in spa treatments from massage to manicures.
Call us on 01252 784 800 or alternatively JOIN ONLINE for our fantastic introductory offer. If you are deciding whether or not to join, talk to us first and we can advise you of the best package for your requirements plus tell you all about our current special offers.
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The weekend is half way over. Thus far it's been a fun one. Friday night was my Xmas party with work. Tons of fun times. Still waiting to see what Xmas bonus will be for this year and next week it's only a 4 day work week, which I am excited about, … [Continue reading]
Weekend Ramblings
Canadian Debt Level Exceeds US!
[retweet] For the first time in 12 years or so, Canadian debt level has exceeded our friends south of the border. Surprise huh? Well not really, this has been coming for sometime to come, roughly since October of last year. The ratio that is used … [Continue reading]
Fine dining on a budget!
We all enjoy eating at a lavish restaurant and we've all had the pleasure to experience this one way or another. For example I have experienced lavish restaurants through work, which most have taken place in Las Vegas or Toronto. Needless to say, the … [Continue reading]
Yaba Daba Dooo…its Friday!!!
[retweet] Yeah you read it right, its "Yaba Daba Doooooo". Glad the weekend is here and this Fred Flinstone is about to get his weekend started, yet sounds like a busy weekend ahead too might I add. Besides the usual stuff, like laundry and … [Continue reading]
Traped in Debt? …Here are your 4 Escape Routes!
[retweet] We all carry some form of debt, no matter who you are. Just that there is good debt (such as a mortgage) and bad debt (any consumer debt, credit cards, loans, line's of credit). Now I am not saying debt is a good thing to have, heck at … [Continue reading]


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A man hit by a car and killed on the Hawthorne Bridge Sunday is believed to have been watching his wife participate in dragon boat races on the river below.
Police revealed that information Monday regarding the death of Robert Espeseth, 58.
Investigators said he attempted to move from one side of the Hawthorne Bridge to the other shortly after 9 a.m. when he was hit by a car in the center of the bridge.
The Major Crash Team is investigating. Officers said Floyd Davidson, 70, was driving the car and speed and impairment were not factors in the crash.
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Music / Singing - Performance
Sunday, December 2, 2012
Our Lady of the Angels Church
1222 Main Street
Worcester, MA 01603
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Don't miss the WSU Chorus, Chorale and Alumni Singers in concert this coming Sunday evening at 8 pm at Our Lady of the Angels Church, 1222 Main Street, Worcester. Holiday music and light classics will be performed. Tickets are available at the door or in the Dept of Visual and Performing Arts in L-325. General admission: $12, Students and Elders, $5.
Cost: General admission: $12, Students and Elders, $5.
Suggested Audiences: Elders, Adult, College
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Please feel free to contact any of our faculty or staff with questions reguarding our program.
A new faculty member at Eastern, Daniel Bigler holds a masters degree in Children's Studies from King's College London and is finishing an additional degree in Children's Rights at the University of Fribourg in Switzerland. He has previously worked in a Reggio Emilia-inspired preschool, studied children's play and peer cultures in an adventure playground in London, and been involved in a number of groups that advocate for greater play opportunities for children in the United States.
His current research interests include children's play and play spaces, the hidden 'street' cultures of children, incorporating children as co-researchers in academic research, and the history of organizations like the Boy Scouts and summer camps and their influence on concepts of 'Childhood'. In his personal life, Daniel also spends a lot of time exploring big cities and imagining himself as a dinosaur.
Sue Marie Wright, Ph.D., served as Director for the Children's Studies Program at Eastern Washington University from the Program's inception in 2002 until the year 2013. She currently holds a position as Professor in the Department of Sociology and Justice Studies, teaching courses on children, gender, and family. Published articles include "Bridging Third-Wave Feminism and Family Pluralism" (2004).
Maria, a life-long resident of the Spokane, WA area, recived her BS in Applied Developmental Psychology in 2008 and then received her MS in Social Work from EWU in 2010. Starting as Program Coordinator for Children's Studies in 2014, Maria provides support to the program and works to advise students in the Children's Studies Online Program.
Trevor obtained his MS in Applied Psychology: Mental Health Counseling as well as his Master's Certificate in Addiction Studies from EWU in 2014. Trevor currently works as a mental health and addiction counselor for Daybreak Outpatient in Spokane Washington serving youth ages 12-17 and is an adjunct instructor for the Children's Studies Program. Trevor has collaborated in many community outreach research studies during his student and professional careers at Eastern Washington University. These studies focused on the topics of: Engaging middle-school youth, their families, and communities in academic achievement, collective impact, moral disengagement, and compassion in relation to psychological well-being.
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A gunman randomly firing from his pickup truck killed 1 person and injured 5, including the sheriff of Concho County, Texas, on Sunday before the suspect was killed in a shootout with police, authorities said.
Authorities recovered an assault rifle, a handgun and countless rounds of bullets from the suspect, who was said to be 23 years old and from North Carolina. The name was withheld pending notification of family members, the Texas Department of Public Safety mentioned in a report.
The statement recognized the dead victim as Alicia Torres, 41, who was shot dead in her vehicle, the report said. The Texas Rangers, local police and Texas Parks and Wildlife were examining several scenes in Concho County, about 250 miles southwest of Dallas, after the early morning shooting spree.
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OOC: And now I have an idea for the Autobot Leader.
OOC: Wait, we're using new characters?!
OOC: Yeah, we are.
Know what else? I saw no character development, no one going against the flow... Just everyone being completely static. I wanted some 'damn, how will this impact my life?' or 'what the hell am I!?'. But instead, it's just run, fight, run. Blah, blah, without any 'maybe the Project is right', or 'why am I with these creeps?'.
There was a little of that.
And I don't see why we're still using 'OOC' now, seeing as this RP looks dead.
Four entire RPs... I had fun for the two I was in.
Anyway, the only thing I know about Transformers is the stuff from the cartoon show I saw when my little brother was watching it a year or so ago.
That show... had giant robots in it.
And out-of-place small children that shouldn't have been working with those giant robots.
You should read Cucumber Quest because it's a rad webcomic that anyone can enjoy.
OOC: I'm just saying what's the point in going through all this trouble when the possibility of a sequel has already been thrown in the trash. Not to mention nobody has any ideas that could bring the story along or to a close. |:<
OOC: It's always me to have to take the first step, isn't it? Look, we're supposed to be confronting the Project, but no one's contextually suggesting it.
"Hold on," Anthony spoke up, "We should go and finish the Project once and for all, right? I bet we could do that now, if we choose."
OOC: Wait, I've got it! A sequel idea with a completely new take! No more venturing around!
OOC: Was that even remotely positive? Your post sounds like sarcasm. Nor does my character even know about the project,so how would I bring up something he has no clue about?
OOC: I'm all eyes... Because I can't do much with my character or start any commotions whatsoever without something to go on. Then it'd be pointless.
OOC: like the project get the funds to plan a false event,which is just a trap to see of they're experiment can be mass produced?


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We're scoreless after a rainy first half in Houston. Houston won the possession battle but the Revs had a few quality chances (view stats), including this one from Benny Feilhaber on a free kick:
The Revs are warming up in Houston and hope to be the first MLS team to pick up three points at BBVA Compass Stadium. Here are tonight's lineups.
#Revs lineup: Shuttleworth - Alston, Soares, McCarthy, Barnes - Cardenas, Feilhaber, Simms, Rowe - Imbongo, Bengtson
— NERevsLive (@NERevsLive) September 29, 2012
#Revs bench: Reis, Roach, Gavin, Fagundez, Toja, Brettschneider, Purdie
— NERevsLive (@NERevsLive) September 29, 2012
Tonight's starting XI: Hall; Sarkodie, Boswell, Taylor, Ashe; Davis (C), R. Clark, Moffat, Garcia; Bruin, Carr #MLS #HOUvNE
— HoustonDynamo (@HoustonDynamo) September 29, 2012
Available subs: Deric, Ching, Weaver, Camargo, Creavalle, Kandji, Hainault #MLS #HOUvNE
— HoustonDynamo (@HoustonDynamo) September 29, 2012
Just want to wish Revolution friend and supporter Danny O'Connor the best of luck in his 20th professional boxing match this Saturday night at the MGM Grand Theater at Foxwoods. Re-live Danny's August 12 bout at Gillette Stadium that followed the Revs' match against Montreal below. Wish Danny good luck in the comments!
Who will step in for Lee Nguyen? Will Juan Toja's playing time increase once again this Saturday? Will JWro run away with the predictions title? All this and more in another action-packed episode of The Far Post Podcast.
And as I said on the show - we want to hear from you! Listen to the show and leave us a comment or question.
As promised yesterday, here is a hi-res downloadable cover featuring Benny Feilhaber for your brand-spanking new FIFA 13 game. We'll have more on today's FIFA 13 launch later on with the Revolution rookies seeing their virtual 'selves for the first time.
Click the image to grab the full-sized download, or right-click (CTRL-click on mac) and choose 'save image as' to download.
Apparently a lot has happened since the last time New York won in Foxborough...
Darrius Barnes' first MLS goal could not have come at a better time for the Revolution. Watch Barnes knock home a 95th-minute header past Red Bulls' goalkeeper Bill Gaudette to equalize for the Revolution and keep their now 16-game unbeaten streak vs. New York at Gillette in tact.
We're scoreless at halftime, despite several great chances by the Revs, including one by Jerry Bengtson which found the back of the net but was called back for offsides. Each side also had an injury substituion, as Flo Lechner left the game with left knee injury (Stephen McCarthy subbed on) and Rafa Marquez left the game for the Red Bulls with a right hamstring injury (Joel Lindpere subbed on).
Red Bulls GK Bill Gaudette has come up big, making three first half saves.
Check out MLSSoccer.com's MatchCenter for more highlights, stats and more here.
Great crowd here tonight at Gillette Stadium - check out some instagrams taken by fans in attendance:
Tonight's lineups are in - follow along live on Twitter (@NERevsLive) here, and watch on Comcast SportsNet beginning at 7:30 p.m. ET.
#revs lineup: Shuttleworth, Alston, Soares, Barnes, Lechner, Nguyen, Guy, Simms (c), Rowe, Fagundez, Bengtson
— NERevsLive (@NERevsLive) September 22, 2012
#Revs bench: Reis, Gavin, Toja, Feilhaber, McCarthy, Cardenas, Imbongo
— NERevsLive (@NERevsLive) September 22, 2012
#NYRB lineup: Gaudette, Conde, Pearce, Holdersson, Lade, Solli, Marquez, Tainio, McCarty, Cahill (c), Le Toux
— NERevsLive (@NERevsLive) September 22, 2012
#NYRB bench: Robles, Sam, Lindpere, Hertzog, Keel, Barklage, Cooper
— NERevsLive (@NERevsLive) September 22, 2012


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Four-Year Colleges & Universities
Four-Year Arkansas Colleges & Universities ranked by most recent year's fall enrollment. Also includes enrollment from previous year, most recent year's in-state and out-of-state tuition, president or chancellor, year founded, and website. Updated 5/5/2014
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- Early Childhood Development
- Early Childhood Development Course Descriptions
- Early Childhood Development Saturday Workshops 2011-12
- Faculty
- Workshop Descriptions Fall 2010
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- Kate Hemsoth
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- Workshop Descriptions Spring 2011
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- Meet our Students
- Transfer Program Overview
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- Saturday Workshops
- Visiting the Bing Nursery School and Summer Institute
Frequently Asked Questions
Who do I talk to if I'm interested in this degree?
You should contact Angela Huftill at 541-552-6332 or KC Sam at 541-552-6936.
Where do I take the lower division course work?
You can take your General Ed courses at SOU or at your local community college. It's important that the lower division (100-200) courses meet SOU's transfer requirements. For information visit the transfer agreement page. Use the drop down menu to select the community college you are currently, or plan to attend.
What if I've taken classes but was not in an Early Childhood program - where would I start?
The best thing to do is have your transcript evaluated so you get an idea of how many of the general education and pre-requisite courses you have met. We will outline which classes you may still need and work with you to find these classes. There is no cost or obligation for the transcript evaluation. Just fax your unofficial transcripts from all your previous college work to KC Sam at 541-552-6287.
When should I start the program or begin working on the Bachelor's degree?
Ideally, you should begin the coursework during your freshman year combining early childhood courses with your general education requirements. We have transfer agreements with many of the community colleges in northern California and Oregon. The agreements assist students with identifing the required courses. If you decide to begin working on the ECD later in your college career, you would still need to take some lower division early childhood education coursework through your community college. Enrollment at both SOU and community colleges (co-enrollment) is very common and will not affect your financial aid. It is important that if you plan to be enrolled in classes at both a community college and SOU and receive financial aid that you complete a concurrent enrollment form and submit it to your home institution's financial aid office at least two weeks prior to the beginning of each term. The form is available online. Scroll down the page to Consortium Agreements.
What if I want to be in the online Bachelor's degree program but do not have the necessary lower division early childhood courses?
An advisor will review your previous coursework and make suggestions on which classes you may still need.
What if I don't want to delay my graduation by taking the lower division coursework?
You could minor in Education, focuing on ECD courses and majoring in your preferred field.
Can I teach with the ECD?
Yes, you can teach in early childhood settings, for example, HeadStart Programs or in private preschools. If you want to teach in public schools you will need to get a license through an Initial Licensure program. The Elementary Education Bachelor's degree or the Master of Arts in Teaching (MAT) program.
Are any of the lower or upper division ECD courses delivered on the SOU campus?
No, all lower division courses need to be completed at a community college. The upper division courses that make up the core & elective courses for this degree are available only online. The upper division general education courses can be taken on campus or online.
After I earn my ECD, how do I get into the MAT program at SOU?
By letting your advisor know of your plans to pursue the MAT early, they can help you plan your coursework, to assure you have completed the necessary prerequisite courses for the MAT. You will still need to go through the process of applying for the MAT and complete requirements for the MAT - for example; PRAXIS exam, letters of recommendation and practicum in public school settings.
If I'm interested in getting my MAT, when should I meet with an advisor?
Ideally, the beginning of your Junior year you should make an appointment to meet with the MAT program advisor in the Education Dept.
If you have any other questions, don't hesitate to email KC Sam or call her at 541-552-6936.


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A car reaching the milestone 50th birthday of its introduction will often move up in collectibility and value.. Five cars that were "all new" in 1962 will be celebrating their Golden Anniversary this year: Shelby's Cobra, the MGB, Pontiac's Grand Prix, Ford's Fairlane and the Chevy II/Nova
We think that 2012 will generate lots of interest in each of these '60s classics and in their performance, sportiness, luxury, practicality in today's hobby and overwhelming popularity. Any of these cars may be a good automotive nvestment to make in 2012. Look for them at the Arizona auctions.
Gunner's Garage with John Gunnell
"Gunner" is one of of the most prolific authors and most visible characters in the old car hobby. He has written dozens of books about old cars for Krause Publications and is the former editor and publisher of Old Cars Weekly. His collecting pursuits range from old Pontiacs, to MGs, to retired police cruisers, to Indian motorcycles. He remains a frequent contributor to Old Cars Weekly and owns and operates Gunner's Great Garage, a classic car restoration and gift shop in Manawa, Wis.
Save 78% Today!
The 2015 Collector Car Price Guide is NOW AVAILABLE and you do not want to miss out. This guide contains over 250,000 listings from over 140 car and truck makers.2015 Collector Car Price Guide
Check these out too:
Old Cars Auto Restoration Guide Vol. II
Standard Catalog of Chevrolet 1912-2003
Standard Catalog of Pontiac 1926-2002
Standard Catalog of Ford 1903-2002
- Automotive Marketplace


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StarveTheEgo, FeedTheSoul
Laura. Passionate about nature and snowboarding.
Bassnectar is my bible. Sophomore at WSCU, Gunnison :)
Studying Rec & Outdoor Ed and Photography
My soul resides in Colorado, one of the most beautiful places my eyes has encountered.
I crave for liberation, the never ending emotion that is like no other.
Come as you are.
Lost in the lights
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Biochemistry 402
Site-specific recombination and transposition of DNA 2_1.ppt
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Biochemistry 402
University of Tennessee - Knoxville
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Site-specific recombination and transposition of DNA 2 Chapter 11 pp 339-368 DNA transposons DNA transposons transpose by a cut and paste mechanism DNA strand Transfer Transposition leads to a direct target site duplication at the TE integration site 3? A C T T T G C 3? T G A A A C G TGAAACG ACTTTGC ACTTTGC TGAAACG TGAAACG ACTTTGC The non-transferred strand may be cut by alternative mechanisms P element transformation in Drosophila LTR-retrotransposons LTR-retrotransposons and retroviruses move using an RNA intermediate Functional and structural elements of LTR-retrotransposons and retroviruses PBS: primer binding site PPT: polypurine tract GAG: viral capsid proteins ENV: membrane associated envelope proteins POL: encodes for a polyprotein responsible for all enzymatic activities: Protease RT RNase H integrase Integrases promote integration of DNA at the target site and are structurally conserved among transposable elements across TE classes Poly-A retrotransposons lack LTRs All promoter elements are downstream of the transcription initiation site It also encodes for a Reverse transcriptase (RT) but Poly-A retrotransposons require an alternative mechanism of transposition ORF1 encodes Ribonucleoproteins that interact with the RNA ORF2 encodes RT plus endonuclease activity Poly-A or non-LTR retrotransposons move by a target site primed reverse transcription Examples of TEs Tn10 are composite bacterial transposons IS10 elements can transpose independently, but the association with resistance genes provides an advantage to the Tn10 composite Tn10 autoregulates its own transposition by transcribing an antisense RNA Levels of antisense are regulated by the number Tn10 copies in the genome (high number = high levels) Bacteria regulates Tn10 by DNA methylation and Tn10 transposition is coupled to the host DNA replication Tn10 uses IHF from l-phage and transposes only when l-phage integrates in the genome High levels of Mu transposition are possible because of Target Immunity mechanisms Phage Mu is similar to l-phage The Mu genome has more than 35 genes During lytic cycle, Mu can transpose more than 100 times per hour Mu induces high rates of mutations in the host bacteria (Mu stands for Mutator) LTR-Retrotransposons transpose via viral particles similar to those of retroviruses. ?save heavens? in the genome lead to site specific integration of TEs Other examples: Transposable elements integrating in the telomeres in insects Transposable elements integrating in rDNA. Ty1 and Ty3: integrate upstream start sites from promoters initiated by Pol III (tRNA genes) Ty5: integrate in regions that are preferentially silenced (telomeres, rDNA) Integrases promote integration of DNA at the target site and are structurally conserved among transposable elements across TE classes LINES and SINES in vertebrates transpose by a target-site-primed reverse transcription LINE: long interspersed nuclear element (human LINE-1 is the most common) SINE: Sort interspersed nuclear element (alu sequences are the most common) LINES provide the enzymatic machinery for SINE transposition and are the origin of processed pseudogenes in mammals Why LINES do not lead to more unspecific cellular mRNA retrotransposition? LINES and SINES make up more than 30% of the human genome piwiRNAs control TEs transposition in higher eukaryotes TEs may have originated important cell functions example: generation of antibodies in vertebrates V(D)J recombination takes place between V D and J regions in genes encoding antibodies DNA encoding heavy chain The mechanism leading to variable regions in antibodies is know as V(D)J recombination and occurs during differentiation of B-cells DNA encoding light chain Recombination signal sequences (RSS) directly participate in V(D)J recombination Strand cleavages during V(D)J recombination are similar to transposition excision RAG1 and RAG2 are recombinases and they introduce single strand breaks at the junctions between the RSS and the gene segment that will be rearranged. RAG proteins function similar to Hermes transposases and have their origin in the Transib DNA transposon.
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text:
Fraud Alert!
There is a SCAM going around targetting our members directly. They are calling and claiming to be representing SYIX, and asking you to send your payment to some address in another city! NOT US!
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My Win7 computer had about 70Mb of updates to do, be sure you get yours patched this week!
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My current (June 2014) answer is:
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text:
After Kira's life is threatened, Sarah is on the warpath, but Dr. Leekie makes her think twice about her plans for revenge. Meanwhile, Cosima faces the truth about Delphine, forcing her to choose sides. Now, it's up to Sarah to decide the killer's fate, but the truth about where Sarah came from changes everything.
Season 1 Episodes View All
Unconscious Selection
Season: 1 | Episode: 9 | Original Air Date: 25 May, 2013


text:
Share your comments
DearS. Vol. 2
Momo no Tane
Teen Fiction MOMO
Momo no Tane
Teen Fiction MOMO
Summary: Takeya and his sexy "slave" girl Ren, a member of the alien DearS race, find their lives even more complicated when an DearS agaent arrives to bring Ren back to the community.
Be the first to add a comment! Share your thoughts about this title. Would you recommend it? Why or why not?
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text:
The guy whose depth and sex appeal of eyes I'd never seen anything like before.
The guy who courted me the right way.
The guy who took his time getting to know me.
The guy who always opened the car door for me, and reflexively pushed back the chair for me.
The guy who always wanted to sit next to me at tables in restaurants, as opposed to across from me.
The guy who didn't try to be witty or to show off.
The guy who was masculine in essence.
The guy who was sweet and noble in character.
The guy who told me he thought I was the girl he'd been waiting for his whole life, over stuttered, shy, careful words…
The guy who told me he wouldn't mind marrying me.
The guy who told me wanted to be with me, always.
The guy who told me he wanted to be as close to me as possible.
The guy who told me it was me and him, "fuck everybody else."
The guy who told me he would kill my enemies with me and be clutch for me.
The guy who told me he would never want me out of his life completely.
The guy who told me he would always have romantic feelings for me.
The guy who told me he couldn't say no to this gorgeous face.
The guy who made breakfast for me every morning.
The guy who didn't text or get texts from any girls.
The guy who put me above his friends and school.
The guy who made me cum so consistently, and more times I ever had in my life.
The guy who always had free time for me.
The guy who said "Whatever you want," concerning what to do.
The guy who would drive a hour to my house just at the suspicion that I'm crying on the phone.
The guy who would pick a fight with a guy on the street at the sight of him hitting on me.
The guy who would reflexively defend me when I'm in a fight with anyone.
The guy who would say, "No, stay, just sleep over, because I care about you," after a fight instead of letting me drive home for a hour at night.
The guy who would push my hood back, and make me face him and not hide in the middle of a fight.
The guy who would pull me back into his house instead of letting me go home.
The guy who would drive to my work to talk it out, instead of fight through text.
The guy who persisted and saw gold in me.
The guy who told me before meeting me, he was kinda just doing whatever, but after knowing me, he had something to be happy about.
The guy who would say "April… why are you still crying?" in bed, in silence, before falling asleep.
The guy who was masculine enough to fix and make things, like my car lights or stereo.
The guy who was manly enough to always drive and make me sit in the passenger seat.
The guy who was manly enough to always be able to realize our plans through planning and world-knowledge.
The guy who would exercise with me and make sure I got a real work out.
The guy who sang to me in the car on the drive home from Vegas.
The guy who was so reliable and always picked up my call or called me back.
The guy who would remember our plans and never leave them unfinished - in the beginning.
The guy who was finally decent, honest, and loyal.
The guy who had swag, but dressed casually (perfect).
The guy who had a strong back.
The guy who was in touch with survival and the out-doors.
The guy who knew little things here and there about health.
The guy who accepted my crazy interests.
The guy who loved food and to cook. :)
The guy who just liked to chill.
The guy who gave me his all.
From now until the 19th, you tend to be more positive in your outlook, dear Taurus, with Mercury moving through your solar ninth house and in harmony with your own sign. You embrace new ways of looking at old problems, and you prefer not to focus too much on the details in favor of the "big…
"But only I can live my life,
And only I can feel my heart break."
You never thought it would happen, did you?
"Love isn't safe. And whoever you love will hurt you. It's part of the human experience. No one is perfect… people make mistakes. The secret is to focus on what they do right and decide what quirks you can live with."
(Source: onlinecounsellingcollege)
"we're both the same way. sensible girls but when we love we throw any rationality out the window"


text:
Show of force: US, South Korea hold naval drills amid North's nuclear threats
A U.S. nuclear-powered submarine is docked Friday in South Korea ahead of joint exercises that are partly a deterrent to North Korea as it vows to conduct another nuclear test.
SEOUL, South Korea — South Korean and U.S. troops began naval drills Monday in a show of force partly directed at North Korea amid signs that Pyongyang will soon carry out a threat to conduct its third atomic test.
The region is also seeing a boost in diplomatic activity focused on North Korea's announcement last month that it will conduct a nuclear test to protest U.N. Security Council sanctions toughened after a December satellite launch that the U.S. and others say was a disguised test of banned missile technology.
Pyongyang's two previous nuclear tests, in 2006 and 2009, both occurred after it was slapped with increased sanctions for similar rocket launches. As it issued its most recent punishment, the Security Council ordered North Korea to refrain from a nuclear test or face "significant action."
North Korea's state media said Sunday that at a high-level Workers' Party meeting, leader Kim Jong Un issued "important" guidelines meant to bolster the army and protect national sovereignty. North Korea didn't elaborate, but Kim's guidelines likely refer to a nuclear test and suggest that Pyongyang appears to have completed formal procedural steps and is preparing to conduct a nuclear test soon, according to South Korean analyst Hong Hyun-ik.
"We assess that North Korea has almost finished preparations for conducting a nuclear test anytime and all that's left is North Korea making a political decision" to do so, Defense Ministry spokesman Kim Min-seok told reporters Monday.
The spokesman said he couldn't disclose further details because they would involve confidential intelligence affairs. Recent satellite photos showed North Korea may have been sealing the tunnel into a mountainside where a nuclear device could be exploded.
Live-fire exercises
On Monday, South Korean and U.S. forces kicked off three-day exercises off the Korean Peninsula's east coast that involve live-fire exercises, naval maneuvers and submarine detection drills.
South Korea's Joint Chiefs of Staff said the maneuvers are part of regular joint military training that the allies had scheduled before the latest nuclear tensions began. But the training, which involves a nuclear-powered American submarine, could still send a warning against possible North Korean provocation, a South Korean military official said, requesting anonymity because of department rules.
North Korean state media on Saturday described the drills as a joint exercise for a pre-emptive attack on the country. North Korea has said similar things when South Korea and the U.S. conducted other drills; the allies have repeatedly said they have no intention of attacking the North.
North Korea says U.S. hostility and the threat of American troops in South Korea are important reasons behind its nuclear drive. The U.S. stations about 28,500 troops in South Korea, a legacy of the 1950-53 Korean War, which ended with an armistice, not a peace treaty.
North Korea also has denounced sanctions over its rocket launches, saying it has the sovereign right to launch rockets to send satellites into orbit under a space development program.
North Korea's two previous nuclear tests are believed to have been explosions of plutonium devices, but experts say the North may use highly enriched uranium for its upcoming test. That is a worry to Washington and others because North Korea has plenty of uranium ore and because uranium enrichment facilities are easier to hide than are plutonium facilities.
Diplomats are meeting to find ways to persuade North Korea to scrap its nuclear test plans. New U.S. Secretary of State John Kerry and his South Korean counterpart, Kim Sung-hwan, held a telephone conversation Sunday night and agreed to sternly deal with any possible nuclear provocation by North Korea, Seoul's Foreign Ministry said in a statement.
The chief nuclear envoys of South Korea and China met in Beijing on Monday and agreed that they would closely coordinate on ways to stop North Korea from conducting a nuclear test, according to Seoul's Foreign Ministry. China is North Korea's main ally and aid provider.
North Korea: Rocket launches, nuclear tests will 'target' US
North Korea: Sanctions by South would be 'declaration of war'
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text:
Courtyard By Marriott Madison East
Courtyard By Marriott Madison East in Madison
Courtyard By Marriott Madison East
Hotel Guest Rating: 9.4/10
2502 Crossroads Drive
Madison, WI 53718
Welcome to the Courtyard By Marriott Madison East
Wonderful staff, beautiful common areas and very comfortable rooms are just a few of the positive aspects of the non-smoking Courtyard by Marriott Madison East, a favorite among Priceline guests.
Hotel Features
One of the highlights of this four-floor hotel is its newly renovated lobby, adorned with plenty of comfortable seating and sporting a clean, modern aesthetic. Another lobby feature is the GoBoard, an interactive touch-screen that allows guests to make restaurant reservations and print boarding passes. Each of the Courtyard by Marriott's 112 spacious rooms feature plush mattresses and cozy comforters, free Wi-Fi, flat-screen TVs, mini-fridges and microwaves. The hotel also contains an indoor pool, restaurant, fitness room and 24-hour business library.
Hotel Location
The Courtyard by Marriott is located off I-94 on Madison's east side, just 8 miles from downtown Madison and the University of Wisconsin campus. The East Towne Mall is one mile from the hotel, and the Madison Children's Museum is within a 15-minute drive. The hotel is 5.5 miles from Dane County Regional Airport.
Guest Favorites
State-of-the-art style and amenities at an amazing price make the Courtyard by Marriott Madison East an A-1 deal.
Courtyard By Marriott Madison East Amenities
- 24-hour front desk
- Accessible facilities
- Accessible parking
- Air conditioning
- Air conditioning individually controlled in room
- Alarm clock
- AM/FM radio
- Boarding pass print-out available
- Business center
- Business services
- Cable television
- Check cashing policy
- CNN available
- Cocktail lounge
- Cocktail lounge with entertainment
- Cocktail lounge with light fare
- Coffee shop
- Coin operated laundry
- Color television
- Complimentary coffee in lobby
- Complimentary in-room coffee or tea
- Complimentary newspaper in lobby
- Connecting rooms
- Dry cleaning
- Efolio available to company
- Elevators
- ESPN available
- Exercise gym
- Express check-out
- Fitness center on-site
- Food and beverage outlets
- Free high speed internet connection
- Free parking
- Free toll free calls
- Front desk
- Full business center
- Full service housekeeping
- Gift/News stand
- Gym
- Hairdryer
- HBO available
- Health club
- High speed internet access
- High speed wireless
- Housekeeping - daily
- Ice machine
- Individual Efolio available
- Indoor pool
- Interior corridors
- Iron
- Ironing board
- Laundry/Valet service
- Limousine service
- Local calls
- Lounges/bars
- Meeting rooms
- Motorcycle parking
- Non-smoking rooms (generic)
- On-site business center
- On-Site parking
- Outdoor space
- Parking
- Pool
- Premium movie channels
- Public area air conditioned
- Remote control television
- Restaurant
- Room service
- Room service - full menu
- Safe deposit box
- Security
- Telephone
- Valet cleaning
- Valet same day dry cleaning
- Vending machines
- Voice mail
- Wakeup service
- Wedding services
- Whirlpool
- Wireless internet connection in public areas
Hotel Information
Upon check-in photo identification and credit card is required. All special requests are subject to availability upon check-in. Special requests cannot be guaranteed and may incur additional charges. Guests are required to show a photo identification and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
Hotel Guest Reviews of the Courtyard By Marriott Madison EastOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
September 16, 2014
This guest did not leave comments about this hotel.
September 2, 2014
September 2, 2014
Outstanding breakfast and staff
August 25, 2014
This guest did not leave comments about this hotel.
August 18, 2014
This guest did not leave comments about this hotel.
May 13, 2014
March 11, 2014
March 11, 2014
This guest did not leave comments about this hotel.
January 8, 2014
Family Traveling with Teens
This guest did not leave comments about this hotel.
January 8, 2014
Although this hotel is very close to the interstate, it's a little out of the way if you wish to explore Madison (and you should! ). However, the hotel does provide a shuttle to the airport and I believe any place else you wish to go. I needed a row downtown and because their shuttle wasn't running, they paid for a taxi up to about $30 or $40 & would've done the same for my ride back had I needed to use a taxi again-very impressive in my opinion! Although this hotel is a little off the beaten path, if you get a room facing the city, and you should DEFINITELY request this, the view is beautiful! Also the higher up the better but on a clear night you can see the Capitol. The bar has strange hours but they have a little market where you can buy beer & wine until 2 a.m. daily. The pool area is very nice as well. Super comfy beds! In closing I should add that I stay in a lot of hotels and it's been a long time since I've been this impressed with my overall experience. I would also go so far as to say this hotel is definitely in the top ten in Madison! My daughter loves this hotel as well. :) ...
(1 - 10 of 44 reviews)
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- Microtel Inn & Suites By Wyndham Madison East from $51 (0.3mi)
- Staybridge Suites Madison East from $120 (0.4mi)
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text: 25 notes Posted 15, March, 2013 I can't wait. I'm flying to New York in a little over a month for the express purpose of seeing this show. From Vogue: Here Lies Love (the title comes from the phrase Marcos once asked to have inscribed on her tombstone) started as a 2010 all-star concept album whose songs combine ethereal melodic hooks, booty-shaking beats (some courtesy of the British DJ Fatboy Slim), and the real-life words of Imelda and her circle to tell the story of a poor Filipina girl who reaches the pinnacle of wealth and power, losing herself, betraying her nation, and becoming a criminal despot along the way. Having conceived it as an immersive theater piece, Byrne found the perfect collaborator in the dazzlingly gifted young director Alex Timbers, who shares his knack for locating the intersection of irony and sincerity. A fan of Byrne's work (he calls the Talking Heads concert captured on film in Jonathan Demme's Stop Making Sense "a Wagnerian total-theater event"), Timbers has made a name for himself with ingenious postmodern stage mash-ups of rock 'n' roll and history, notably the 2010 hit Bloody Bloody Andrew Jackson. Timbers describes the show as "360," meaning that there is no traditional stage and very few seats, putting the audience right in the middle of the multimedia action (dancing is encouraged). "This is a show for the A.D.D. generation," he says. "It's most exciting when all the elements—music, lyrics, dance, staging, lights, video—collide to create a sense of meaning and emotion."The collaborators wanted to avoid anything that smacked of camp (Byrne: "We don't even mention the shoes") or melodrama (Timbers: "This definitely isn't Evita"). They knew that they would have to pull off a neat trick, creating a portrait of Marcos that didn't vilify or mock or condone her actions. "You can't sort of hate your main character right from the beginning of the show," Byrne says. As Imelda, the young actress Ruthie Ann Miles, who at one point sings "I am the people's star and slave," takes her case directly to the masses (otherwise known as the audience members), sometimes, as she puts it, "singing literally face-to-face, looking right into someone's eyes." Miles describes Marcos as "needy" and "delusional," but she understands where she's coming from. "These people have given her their trust, and she puts them through so much, and then at the end she doesn't understand why they've turned on her. From her perspective, honestly, I don't think she sees that she's done anything wrong. She's only loved, she's only given—and why can't everyone else see it? #Here Lies Love #Imelda Marcos #David Byrne #Vogue #Annie Leibovitz #Fatboy Slim #Alex Timbers


text:
Mother Earth campaign launched for Mother's Day
Press Release 2nd March 2010
Contact: Jane Beaton. 01320 340242; email@example.com
This Mother's Day (March 14th) a new campaign by conservation charity Trees for Life will give people the chance to care for Mother Earth by having a specially-dedicated tree or grove planted in Scotland's Caledonian Forest on behalf of their mothers.
The scheme allows people to tackle climate change and biodiversity loss by helping to restore a
valuable habitat in the Highlands. Following centuries of deforestation, only one per cent of the Caledonian Forest currently survives.
Alan Watson Featherstone, Trees for Life Executive Director, said: "Caring for Mother Earth is one of the best ways to mark Mother's Day in 2010, the International Year of Biodiversity. As we celebrate mothers' care for their children, we can simultaneously create a positive gift for our children by restoring healthy ecosystems like the Caledonian Forest."
Mother's Day sees a huge increase in the sale of cut flowers, which often have a significant
carbon footprint as they are flown to the UK from overseas, with fossil fuels used in their cultivation, transport and refrigeration. Pesticides and artificial fertilisers used to promote their growth also contribute to the negative impact they have on the environment.
By contrast, every tree creates tangible, positive environmental benefits by absorbing carbon dioxide from the atmosphere, providing a habitat for wildlife and boosting biodiversity.
Writer and broadcaster Vanessa Collingridge is backing the new campaign. She said: "As the mother of three boys, I feel it's my job and my pleasure to teach them that the best way to express love is to respect and honour all forms of life, whether human, animal or plant. When it comes to showing you really care, such as on Mother's Day, cut flowers are like an infatuation –
a big thrill that lasts for a week or two. However, the gift of a tree, grove or forest lasts for generations. There's no better way
to show true and enduring love."
Single trees with a personalised certificate cost £15. Groves of eight trees, with a certificate and
a personalised page on Trees for Life's website, cost £50 and extra trees can be added for £5
People can also support Trees for Life's award-winning restoration of the Caledonian Forest by joining its acclaimed Conservation Volunteer Weeks. For more information on the charity, see www.treesforlife.org.uk or call 0845 458 3505.
Notes to editors
- Trees for Life aims to restore the Caledonian Forest to an area of 1,500 square kilometres in the Scottish Highlands west of Inverness.
- Since planting its first trees in 1991 in Glen Affric, Trees for Life has planted over 820,000 trees.
Its awards include 1991 UK Conservation Project of the Year, the Millennium Marque in 2000
and Top 10 Conservation Holidays worldwide (in 2009).
- Trees for Life is a partner in the world-wide celebrations of 2010 as the International Year of Biodiversity. The diversity of life on Earth is crucial for human well-being and now is the time to act to preserve it. For information on events, initiatives and exhibitions across the UK visit www.biodiversityislife.net
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Do you ask yourself why most of the search engines
Do you ask yourself why most of the search engines provide on-the-fly access to their resources? Such sites compress their content as much as possible so they can provide quick and reliable access to their content to millions of users. MetaCompress packs requested content of a web site on-the-fly. This will increase your site's accessibility and speed up the loading of pages on your site in general.
dlTube.net did not scan MetaCompress 2.1 for viruses, adware, spyware or other badware.
For your own safety, we recommend that you always have an antivirus, with virus definitions up to date, installed on your computer when downloading and installing programs from the web.
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-This post was written by American Art/Portrait Gallery Library (AAPG) Spring 2014 intern Sara Cecilia Johnson. Joseph Stella's paintings sit quietly, unnoticed on the second floor of the Smithsonian American Art Museum. People often pass them by, maybe one or two stopping to admire the vibrant color or dynamic movement, but otherwise Stella remains an obscure, unfamiliar name to the average American. What they don't know about is his striking spectrum of more »
Through the generosity of an artists' book enthusiast (and a member of the Smithsonian Libraries staff), the American Art Museum/National Portrait Gallery (AA/PG) Library has recently acquired a copy of a new book depicting scenes from a classic Brothers Grimm fairy tale: Hansel and Gretel: A Shadow Theatre Book.
–This post was contributed by Kimberly Lesley, American Art and Portrait Gallery Library intern, summer 2012. This summer I had the opportunity to work on two projects at the Smithsonian American Art Museum/National Portrait Gallery Library: evaluating titles from the print reference section and selecting public domain titles for digitization. The majority of time was spent on the former, evaluating once heavily relied upon indexes and reference titles against databases and open access online resources. As I paged through volumes of reference titles I was grateful for the vast amounts of information available online with a few keywords and a couple clicks.
A while ago, before the internet, I became interested in studying Saharan rock art, one of the most beautiful and extensive bodies of prehistoric art, but documentary references were hard to find. This is partly because most of the published literature on Saharan rock art is in French, Italian and German.
In Woody Allen's latest film Midnight in Paris, a modern-day writer finds himself repeatedly traveling back in time to Paris at the height of the 1920's. While there he meets a number of the period's famous writers and artists, from Ernest Hemingway and Gertrude Stein to Salvador Dali and Pablo Picasso. Seeing this film made me want to learn more about the fascinating lives of these people, so I decided to research Scott and Zelda Fitzgerald, who in the film introduce us to the world of Paris in the twenties.
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