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text:
A Trial of BKM120 (a PI3K Inhibitor) in Patients With Triple Negative Metastatic Breast Cancer
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to evaluate the clinical activity of BKM120 in patients with metastatic triple-negative breast cancer who have developed disease progression after standard chemotherapy in the adjuvant or metastatic settings.
Breast Cancer
Drug: BKM120
Phase 2
|Study Type:
|Study Design:
|Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase II Trial of BKM120 (a PI3K Inhibitor) in Patients With Triple Negative Metastatic Breast Cancer
- Rate of clinical benefit = CR + PR + SD for ≥4 months per RECIST 1.1 [ Time Frame: Rate of clinical benefit for at least 4 months ] [ Designated as safety issue: No ]
- Progression-free survival [ Time Frame: Every 8 weeks from study entry to up to 2 years ] [ Designated as safety issue: No ]
- Overall survival [ Time Frame: 2 years ] [ Designated as safety issue: No ]From recruiting date until death by any cause.
- Frequency and severity of adverse events [ Time Frame: Continuous, until 30 days after treatment stops ] [ Designated as safety issue: Yes ]
- Molecular alterations in tumor tissue that correlate with clinical activity of BKM120 [ Time Frame: 2 years ] [ Designated as safety issue: No ]
- Change from baseline in expression levels of p-AKT and S6 in tumors [ Time Frame: At day 28 of cycle 1 ] [ Designated as safety issue: No ]
- Change from baseline in glucose metabolism markers [ Time Frame: At day 28 of cycle 1 ] [ Designated as safety issue: No ]
- Rate of clinical benefit = CR + PR + SD for >=4 months per RECIST 1.1 after preselection [ Time Frame: Rate of clinical benefit for at least 4 months ] [ Designated as safety issue: No ]To determine if preselection of patients depending on specific tumor molecular alterations can increase the probability of a clinical response to BKM120
|Estimated Enrollment:
|Study Start Date:
|June 2012
|Estimated Study Completion Date:
|June 2016
|Estimated Primary Completion Date:
|June 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: BKM120
Drug: BKM120
BKM120 oral capsules. 100 mg daily in cycles of 28 days, until disease progression
Detailed Description:
This is a prospective, non-randomized, open-label, multicenter, single-arm exploratory study of single agent BKM120 in the treatment of metastatic triple negative breast cancer patients that have progressed to at least 2 lines of chemotherapy in the neoadjuvant, adjuvant, or metastatic setting.
Patients will first undergo screening, tumor measurement and collection of available tumor block from the primary tumor and/or a metastatic site. Available tumor block is required in all patients per inclusion criteria. Analysis of this tumor block will be used for correlation of predictive markers and clinical response in order to define potential subpopulation that benefit from BKM120.
Following confirmation of eligibility criteria, subjects will be enrolled. BKM120 will then be administered in a 100mg dose, orally, once daily, in a continuous schedule. A treatment cycle is defined as 28 days for the purposes of scheduling procedures and evaluations.
Treatment with BKM120 will continue until disease progression, unacceptable toxicity that precludes any further treatment, and/or discontinuation of the treatment by investigator or patient decision.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Pathologically and radiologically confirmed metastatic TNBC (Stage IV disease), previously documented by histological analysis, which is ER-negative and PR-negative by IHC and HER2 negative by IHC or FISH/CISH.
- Subjects must have received at least two prior neoadjuvant chemotherapy regimens, adjuvant or metastatic
- Availability of a representative tumor specimen (primary or metastasis, archival tissue or fresh biopsy for patients with biopsiable tumor) at baseline.
- At least one measurable lesion by RECIST 1.1
- Age ≥ 18 years at the day of consenting to the study
- ECOG performance status ≤ 2
- Adequate bone marrow and organ function as defined by the following laboratory values: ANC ≥ 1.0 x 109/L, platelets ≥ 100 x 109/L, hemoglobin ≥ 9.0 g/dL, INR ≤ 2; serum potassium between 3.0mmol/L and 5.5 mmol/L; Corrected serum calcium between8.0mg/dL and 11.5mg/dL (OR between 1.0mmol/L and 1.5mmol/L of Ionized calcium); serum magnesium between 1.2mg/dL and 3.0 mg/dL; serum creatinine ≤ 1.5 x ULN, ALT and AST within normal range (or ≤ 3.0 x ULN if liver metastases are present); serum bilirubin within normal range (or ≤ 1.5 x ULN if liver metastases are present; or total bilirubin ≤ 3.0 x ULN with direct bilirubin within normal range in patients with well documented Gilbert Syndrome); fasting plasma glucose (FPG) ≤ 140 mg/dL or ≤ 7.8 mmol/L.
Exclusion Criteria:
- Previous treatment with PI3K inhibitors
- Symptomatic CNS metastases
- Patients with controlled and asymptomatic CNS metastases may participate in this trial. As such, the patient must have completed any prior treatment for CNS metastases > 28 days (including radiotherapy and/or surgery) prior to enrollment in this study. Patients with previously treated brain metastases, who are on a stable low dose corticosteroids treatment are eligible
- Concurrent malignancy or malignancy within 3 years of study enrollment (with the exception of adequately treated basal or squamous cell carcinoma or non-melanomatous skin cancer). An exception to this rule are those patients with documented germline mutations in BRCA1 or 2, who may have previous history of cancer
Any of the following mood disorders as judged by the Investigator or a Psychiatrist, or meets the cut-off score of ≥ 10 in the PHQ-9 or a cut-off of ≥ 15 in the GAD-7 mood scale, respectively, or selects a positive response of '1, 2, or 3' to question number 9 regarding potential for suicidal thoughts ideation in the PHQ-9 (independent of the total score of the PHQ-9)
- Medically documented history of or active major depressive episode, bipolar disorder (I or II), obsessive-compulsive disorder, schizophrenia, a history of suicidal attempt or ideation, or homicidal ideation (immediate risk of doing harm to others)
- ≥ CTCAE v 4.0 grade 3 anxiety
- Concurrent use of other approved or investigational antineoplastic agent and/or chemotherapy ≤ 21 days prior to enrollment in this study.
- Radiotherapy ≤ 28 days prior to enrollment in this study or failure to recover from side effects of such therapy at the time of initiation of screening procedures.
- Major surgery within 28 days prior to starting study drug or has not recovered from major side effects of the surgery
- Poorly controlled diabetes mellitus (HbA1c > 8%)
Active cardiac disease including any of the following:
- Left Ventricular Ejection Fraction (LVEF) < 50% as determined by Multiple Gated acquisition (MUGA) scan or echocardiogram (ECHO)Note: ECHO/MUGA is only required at baseline if patient has a history of abnormal cardiac test results
- QTc > 480 msec on screening ECG (using the QTcF formula
- Angina pectoris that requires the use of anti-anginal medication
- Ventricular arrhythmias except for benign premature ventricular contractions
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication
- Conduction abnormality requiring a pacemaker
- Valvular disease with documented compromise in cardiac function
- Symptomatic pericarditis
History of cardiac dysfunction including any of the following;
- Myocardial infarction within the last 6 months, documented by persistent elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LVEF function
- History of documented congestive heart failure (New York Heart Association functional classification III-IV)
- Documented cardiomyopathy
- Treatment with QT prolonging medication known to have a risk to induce Torsades de Pointes, and the treatment cannot be discontinued or switched to a different medication prior to starting study drug
- Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of BKM120 (e.g., uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection)
- Chronic treatment with steroids or another immunosuppressive agent. Note: Topical applications (e.g., rash), inhaled sprays (e.g., obstructive airways diseases), eye drops or local injections (e.g., intra-articular) are allowed. Patients with previously treated brain metastases, who are on a stable low dose corticosteroids treatment (e.g., dexamethasone 2 mg/day, prednisone 10 mg/day) for at least 14 days before start of study treatment, are eligible
- Other concurrent severe and/or uncontrolled medical condition that would, in the investigator's judgment contraindicate her participation in the clinical study (e.g., chronic pancreatitis, active chronic hepatitis etc.)
- History of non-compliance to medical regimen
- Current treatment with drugs known to be moderate and strong inhibitors or inducers of isoenzyme CYP3A, and the treatment cannot be discontinued or switched to a different medication prior to starting study drug
- Known history of HIV (testing not mandatory) infection
- Pregnant or nursing (lactating) woman
- Woman of child-bearing potential unwilling to observe total sexual abstinence or to use a double barrier method for birth control throughout the trial. Reliable contraception should be maintained throughout the study and for 6 months after study drug discontinuation
Please refer to this study by its ClinicalTrials.gov identifier: NCT01629615
|Contact: Josefa Morales, PhD
|+34 93 343 63 02
|United States, Massachusetts
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02215
|Contact: Nancy Lin, MD firstname.lastname@example.com
|Contact: Catherine Zeghibe email@example.com
|Principal Investigator: Nancy Lin, MD
|Beth Israel Deaconess Medical Center
|Boston, Massachusetts, United States, 02215
|Contact: Gerburg Wulf, MD, PhD email@example.com
|Contact firstname.lastname@example.com
|Principal Investigator: Gerburg Wulf, MD, PhD
|Dana-Farber at Faulkner Hospital
|Boston, Massachusetts, United States, 02130
|Contact: Eric Mayer, MD, MPH email@example.com
|Contact: Kimberly Washington firstname.lastname@example.com
|Principal Investigator: Eric Mayer, MD, MPH
|Hospital Universitario Vall d´Hebron
|Barcelona, Spain, 08035
|Contact: Susana Muñoz email@example.com
|Principal Investigator: Cristina Saura, MD
|Hospital Universitario 12 de Octubre
|Madrid, Spain, 28041
|Contact: Olga Ortega email@example.com
|Contact: Maria José Aguilella email@example.com
|Principal Investigator: Eva Ciruelos, MD
|Instituto Valenciano de Oncología
|Valencia, Spain, 46009
|Contact: Laura Calabuig email@example.com
|Principal Investigator: Joaquin Gavila, MD
|Hospital Clínico Universitario de Valencia
|Valencia, Spain, 46010
|Contact: Estela Contel email@example.com
|Principal Investigator: Ana Lluch, MD
|Study Chair:
|Jose Baselga, MD
|Massachusetts General Hospital
|Study Chair:
|Eric Winer, MD
|Dana-Farber Cancer Institute
|Principal Investigator:
|Jordi Rodon, MD
|Hospital Universitario Vall d´Hebron
Additional Information:
No publications provided
|Responsible Party:
|SOLTI Breast Cancer Research Group
|ClinicalTrials.gov Identifier:
|NCT01629615 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 23, 2012
|Last Updated:
|September 27, 2013
|Health Authority:
|Spain: Agencia Española de Medicamentos y Productos Sanitarios
Keywords provided by SOLTI Breast Cancer Research Group:
breast cancer
triple negative breast cancer
PI3K inhibitor
Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
ClinicalTrials.gov processed this record on October 02, 2014

subset: commoncrawl


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University of Georgia
Consumer Behavior And Family
Consumer Behavior And Family 1110
Consumer Behavior And Family 1110
University of Georgia
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Introduction to the dual-self model of choice Behavioral economics and consumer decision-making An alternative model Previous discussion shows that the rational, utility-maximizing assumption for consumers is not always true. So, now what? Throw it out the door? But, it often makes accurate predictions A modification from behavioral economics The dual-self model of consumer choice ?Our theory proposes that many sorts of decision problems should be viewed as a game between a sequence of short-run impulsive selves and a long-run patient self.? Drew Fudenburg (Harvard U.) and David K. Levine (Washington U.), 2006, A dual-self model of impulse control. American Economic Review, 96(5), 1449-1476. Fudenberg & Levine (2006) Long-run (patient) self This side tries to maximize utility across time Short-run (impulsive) selves Sequential selves that exist only for a brief time Each cares only about immediate experience Experiment Time! This is real. One of you will be picked to receive one of the choices you selected. Choice One Pick one You can receive $1.00 (cash) on the second to last day of this class. You can receive $1.05 (cash) on the last day of this class. Choice Two Pick one. One week prior to the last day of class, you can have during class either Tangerine Chocolate Bar The dollar value of both is identical. (Of course, the tangerine is a healthier choice.) It?s now time! Get ready, someone is about to get a nice giveaway! Choice Three Pick one. Right now, you can have either Tangerine Chocolate Bar The dollar value of both is identical. (Of course, the tangerine is a healthier choice.) Choice Four Pick one You can receive $1.00 (cash) right now. You can receive $1.05 (cash) during the next meeting of this class. Research Results Read & van Leeuwen (1998). 200 participants. People who were not hungry, chose the unhealthy snack for delivery in one week 26% of the time They chose the unhealthy snack for immediate consumption 70% of the time ? Next Week Right Now ? 26% 70% Dual-self Long-run (patient) self This side tries to maximize utility across time Short-run (impulsive) selves Sequential selves that exist only for a brief time Each cares only about immediate experience Discussion ? Next Week Right Now ? 26% 70% Short-run (impulsive) selves Does the short-run self care about Future consumption next week? Future health consequences? Immediate consumption choice? Discussion Discuss with a neighbor and vote in a moment. Does this result fit better with simple rational decision-making or a two-system approach? Simple rational decision making Two system ?dual-self? decision making (long-run/patient self and short-run/impulsive selves) ? Next Week Right Now ? 26% 70% Class vote comparison How many voted for chocolate at the end of the semester? Fall 2009 ? 62.7% (n=86) How many voted for chocolate right now? Fall 2009 ? 64.8% (n=74) Hyperbolic discounting Would you rather receive $100 right now or $101 in a week? Most people choose $100 right now. But when the choice is between $100 a year from now and $101 in a year and a week from now, most people choose $101 in a year and a week. This is time inconsistent, as both choices involve delaying by one week for $1. Note also that choosing $100 right now implies an interest rate charge of 1% per week or APR of 52% Discussion Now v. later Short-run (impulsive) selves Does the short-run self care about Immediate money? Two different future money options? Later v. much later Class vote comparison How many voted to take the $1 on the second to last day of the class (instead of $1.05 on the last day)? Fall ?09: 32.2% (n=87) How many voted to take the $1 right now (instead of $1.05 in the next class meeting)? Fall ?09: 66.3% (n=86) What is the implied interest rate being charged to those who chose the immediate $1? Next class in 2 days. 5% difference. APR = (365/2) X 5% ? 912% Thoughts to ponder Could the willingness of some to ignore a 920% interest rate for immediate reward have implications for consumer use of credit? Could the variations in the healthiness of food choices have implications for consumer food choices? More later?
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text:
Dark CreationPromises made but never keptThings said but never meantWords are liesThat cause painBroken trustDying heartMind fadingBody witheringYou did thisWith your promises unkeptAnd your words not meantCreating my painful death
ParentlessI know my MotherI know my FatherI know I wasn't wantedI know I was born as a last ditch effortTo save their failing marriageI didn't save itThey couldn't do the kind thingLeave me behindRelingious their rightsMy Mother wanted meSo my Father couldn't have meOnce she had me she had no interstI went to bed hungry so many nightsI didn't have an outfit for anymore than two days a weekMost years one outfit had to last five school daysFrankiepoo came into our livesHe spanked me because Mother said it was okayHe was fed and clothed better than meI leftMy Father promised me a better lifeHe liedI didn't see it at firstI was so happy to have food and clothesA bed to myself, a whole room to myselfIt wore offHe became a monsterMy Mother stepped out of the pictureShe came back inBut left with glee once moreNot before reminding me how worthless and horrid I amMy Father is an alcholicAn assholeHe takes his anger out on meYet claims to love me oh so muchAnd wants nothi
My Personality: Expiration DateMy personalityIt's got an Expiration DateFive years and I'm no goodIn five years you'll decideMy personality sucksI don't know whyBut its happened thriceIt'll happen againI'll be twenty-twoThen again at twenty-sevenAnd so forthThe curse of 5I'll not escapeIn eighteen yearsI've never been proven wrongIt's hard to believe I ever will beThat little bit of hopeFlickers more and moreSoon it will go outDarkness consumingTill I'm nothing, but a tombstone
Lost LifeI lost my lifeWhy?Simple Answer: No one gave a damn about meYou stand here looking down at my faceFrozen in time at eighteenIt shouldn't beThis was not some horrible accidentLook aroundYou are looking at the many faces of my murdersThe Uncle, the eldest brotherWho led by example in mistreating those he claimed to "love"Egged on my father as he followed in his footstepsThe AuntWho hated herself and made it her mission to spread miseryFickle Bitch one minute your Ally; the next plunging a knife in your backThe CousinsKind, but troubledUnable to make a strong, united standThe MotherWho never loved, cared, or worried for her childWho for good (She may not be one of the faces you see, but she had a hand in this.)The FatherVerbally abusive drunk, who one day turned to physical abuseAnd dealt the final blowNo one listenedI was made to be the monsterA little girl who everyone unanimously agreed grew up to be a horrible human beingEven before my life beganThe predict
Safety FirstThe Fool returnsTo prove his loyaltyWhat's his mark?He asksNot importantWould it be that I'd prefer a random kill as proofHe wondersNoThen what?He pressesSafety firstConfusionCommon of all unseasoned killersWho come my way looking for revengeYour gunI hintBut alas he is a foolTo kill meThe safety must be off firstAs it is not-*Bang*
You Left Me StrongerYou Left Me Stronger:Hey there, it's been awhile, do you remember me?I guess you might not, since I wasn't very important to you.You know, I spent so many days thinking about - what I did wrongI questioned if maybe, I was at fault or if I was screwed up.I thought a lot about the things you said...The things that were my fault, my problems.I took them to heart at first, but then I realised you were wrong.I realised that you are selfish and ugly on the inside.On the surface you pretended to care, but like a cancer;You amputate someone the moment you think they've gone bad.You hide from the rigours of life and only emerge like a parasiteWhen everything is good - when everything is fine and dandy.I used to think that I was afraid of you leaving,But now I know, that you've left me stronger than I was before.You know, this was supposed to be an emotional whine; an emotional spill,Maybe I was supposed to cry tears and beg you to come back, but you know wha
I Comfort MyselfWith a warm drink, whispering secrets to my own reflection.The struggles that plague me, though none may know,Are only for the ears of my quiet mirror, who smilesSoftly, warmly and with care. He tells me, I'm fineI've done well for now and soon I may finally rest.Though the silence continues to press upon me,Weighing upon my soul like an iron crate.Still I find comfort in whispering secrets,If only to my own reflection - holding a warm drink...-Chen Yuan Wen, 17th October 2012
LifePassion.When you do something because your gut tells you toWhen you do something for the love of doing itWhen you do something with no monetary goals.Love is When it doesn't matter how many times you talk to someone, Every time you do it again, it's a new, exciting, experienceWhen you do your job without ever having to workWhen you can look in the mirror and feel pride without vanityWhen a smile is on your face and you don't know how it got there.HappinessThe state of being when you do what you Love, and Love what you Do; have Love and Passion
You Have No Right To LiveYou Have No Right To Live:Hey, what are you doing?That's mine, now give it back.You're stupid, you should just go die!Okay, I'm sorry...What, you failed again?Just how much money do you think we're spending on this,Do you think it just falls from the sky?I can't believe you; and don't give me that look!You better straighten up now you hear meAnd if you keep looking like a dead fish,I'm going to make you wish you were one.I'm sorry...Hey, being around you is driving me nuts,You never want to do anything, you don't even care,Why bother even breathing if you're going to act like you're dead!I'm sorry!You'rePatheticWorthlessUselessStupidUgly and-IgnoredA lousy person like you should just go die!okay, fine! I will...-Chen Yuan Wen, 26th November 2012
I should have seenI tryAnd I tryTo be betterAnd betterI try to be perfectI want no faultAll for youI only wish to be everythingAnd give you everythingI didn't knowI was hurting youAgain and againYou told me I was fineThere's nothing wrongI should have understoodAnd accepted myselfWe all have faultsIt doesn't mean there's something wrongI just wanted to reach the impossibleI wanted to be perfectFor youI'm sorryI should have seenYou love meFor me
She always fell for boys who needed saving.She always fell for boys who needed saving.Giving them kisses in the darkto numb their headache fromdrinking too much and yetnot enough to kill lust.She was always adored by boys, who,if given the chance, would rebuildthe world for her.But she wanted to be the heroineand refused to seeshe needed saving, too.
This is All About YouThis Is All About You:Most people giving you advice, might take a quote from a bookMost people giving you advice, have never had a real lookSo from someone who's been watching, let me lay my heart bareI want to show you all the special things, about the girl for whom I careShe always does her very best, no matter how tough the taskEven when she's struggling, she puts on a brave maskShe's always trying to learn new things, just for a chance to make you proudShe can be a little bit quiet, but I think that's better than being loudShe's not the very best in sports, I know she can be kind of a klutzBut she smiles and goes on anyway, now that takes a lot of guts...She gets embarassed pretty easily and gets far too nervous to talkBut I know she'd like it if we held hands, whenever we went for a walkShe doesn't need a lot of pretty things, she just wants someone who caresI bet she'd like to have someone, whom she knew would always be thereI remember when she tried to cook
To The Beautiful YouTo The Beautiful You:Here we are, sitting behind these screens of glass,Reading lines of text, yet smiling, laughing and crying.It's strange to think that I could have this much fun -Considering that I've never met you before, but then againPerhaps that's the reason why I don't have to pretend.Some people might tell me, that what we have is just a fantasy,I doubt I'll have the chance to actually see you in this life-time.But even so, in the time that we've spent together - Well,I feel as though I've connected with you, more than anyone else.I feel as though I know you better, than those just a few feet away.You might take this little confession as something silly,Maybe you'll even forget about it as time passes,But I for one could never forget about someone like you,And so I'd like to dedicate this piece, to the beautiful you.-Chen Yuan Wen, 17th December 2012
Grow UpWhen I was young,I knew a girl.She was so warm and bright,so I asked her that questionthat all children must answer.'What do you want to bewhen you grow up?'Her eyes lit up with joyand she jumped with excitement.'A dancer!No, an astronaut!Wait, President!A scientist!I'll be famousand in movies!My namewill be everywhere!'She listed so many moreuntil she finally just smiledand looked at me with eyes filledwith child-like wonder.'I could be anything I wanted.'Years and years later,I saw the same girl againbut her eyes no longerlit up with wonder.I asked her,'What did you end up being?'She smiled the hollow smilethat adults have when talking to the young.'Not what I wanted to bewhen I was young.'Nothing more was said on the matterbut I could see that there was no more wonderin the eyes that once shone so brightly.
I'd Be Pretty If I'd Just...I'd be pretty if I'd just smileIf I'd cut my hair a certain wayAnd cover myself up in that chemical crap you call make-upBut did you ever think that just maybe...I don't wanna be prettyThat I just wanna be meWho cares if no one ever calls me beautifulWho cares if I'm never asked to danceHell I don't even know how to dance anywayI don't care how the world sees meI only care how I see meAnd I think there's nothing wrong with the girl in the mirrorSure she doesn't smile much but that's cause she's going through hellHer face may look plain without any make-upBut that's just the way I like itAn old pair of jeansThe first t-shirt could findMy hair in a braidI'm ready to goTo where no one cares just what I look likeLeast of all meIt's a barn full of horsesThat's where I choose to spend my daysWhere no one cares about what I wearWhere I never have to hear "I'd be pretty if I'd just..."
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text:
steady,,, steady… 17sale
agree with digital science.
agree to disagree with improper exposure
will they change it?
The Slow sales is over…!!!!!
now its STOP!
I bet you already know what I wanted to write, even though I havent write it. Haha
motionpictors said
Hi cyzer, are you using Nwallet on android ? because i have the same problem, the app doesn't even load in the last 2 days, i thought i was the only one.
Huh! I thought something went wrong with my phone, so i uninstalled it.. hoho
BetaMotion said
My sales dropped more than 50% from previous month.
April 124 sales
May 54 salesAnybody believs this is natural???
that is naturally not natural,
mine is 92 in april, now only 36, haha
congrats man !
a seriously big problem!
time to move on
urrrghhh!... still terrible


text:
FIX: Code blocks embedded in an ASP.NET 2.0 Web page disappear when you use the Generate Local Resource tool in Visual Web Developer to generate a local resource file
Article ID: 969364 - View products that this article applies to.
In Microsoft Visual Web Developer, you use the Generate Local Resource tool to generate a local resource file for an ASP.NET 2.0 Web page. When you do this, any embedded code blocks on this page may be deleted.
For example, you have a Panel control on the ASP.NET 2.0 Web page. The code for the Panel control resembles the following:
Then, you open this Web page in Visual Web Developer, and then click the Generate Local Resource on the Tools menu. However, the following string disappears from the code:
<%=DateTime.NOW.ToString() %>
Therefore, if you view the Source view of this page, the code resembles the following:
Hotfix Replacement InformationThe hotfix that corresponds to KB969364 has been superseded with the hotfix KB981201, which contains all fixes that were previously included in KB969364 . You should use the hotfix KB981201 to fix the issues described in KB969364. For more information, click the following article number to view the article in the Microsoft Knowledge Base:
(http://support.microsoft.com/kb/981201/ )A hotfix is available for ASP.NET 2.0 that enables support for extended protection
Microsoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section.
For more information about the Embedded Code Blocks in ASP.NET Web Pages, visit the following Microsoft Web site:
http://msdn.microsoft.com/en-us/library/ms178135.aspxFor more information about the Resource Files in ASP.NET Web Pages, visit the following Microsoft Web site:
Article ID: 969364 - Last Review: August 4, 2010 - Revision: 3.0


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Thoughts on this upgrade...
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Repulsive By DesignLet me tell you this my friendAnd I will tell you no moreIf my passion is your crimeThen your love should be my lawI'm the exception to the ruleAnd the end of this blood lineI should hang my head in shameI am repulsive by designAllow me to elucidateAnd I will tell you no lieI am charged with being charmlessAnd I have no alibiFeloniously you broke my heartOne chamber at a timeThough I'd expect nothing lessI am repulsive by designBeware of the broken heartedIndeed consider with cautionRepulsion cleansed my sorry soulSuch a spiritual abortionBut when a full term of sorrowAnd low self esteem combineI still remain unloveableI am repulsive by design
My Master's VoiceI screamed at him "I'm leaving!"He smiled and said "okay"I said "no, for once I mean itThis time you wont make me stay"But bags were never really packedAnd that night in our bed I layThe taste of blood on my lipsStill remained there the next dayI screamed at him "please stop this!I am the Mother to your childBaby, I know you have a temperI know my ways make you so wild""But I promise I'll try harderNot to push your buttons so much"With that the beast resumed controlAs I quiver at each stolen touchThey scream at me to leave himTo them it's such a simple choiceBut it's been so long since I've heardAnything but my master's voiceTo the point that I no longer knowMy own mind or my own heartBut today he said he's sorry againAnd tomorrow will be a fresh start
Only When I WriteThe drama unfurling in my lifeFeels like the shadow of my handThat grows as it comes ever closerTo the light perched on my bed standIn that I can feel the darkest cloudEver such a menacing sightIn time I can reverse the feelingBut only when I writeSeclusion left me with nothingApart from creativityLoneliness it turns out, my friendsIs quite the aperitifFor the feast that is awaiting meIf I make it through the nightTomorrow always brings me new hopeBut only when I writeYou approach me on a good dayAnd I will offer you a smileThe same expression on the worst daysBecause my manners are so mildBut don't take me for a toothless foolWhen cornered I've been known to biteFear not, those demons remain at bayBut only when I write
An Ode To A SmileOf late there has been something missingFrom my visage, my mien and my faceMy adult self not able to regainWhat it is my childhood has misplacedThe absence has become more apparentAnd is there for the assemblage to seeBut as it did not happen over nightThe origin remains a mysteryCould it be the colour and the toneOf my sallow skin pigmentationFrom too many hours indoors aloneAnd within my imaginationPerhaps I should pierce my ear and noseRebel against a faceless systemOr indeed tattoo text upon my neckQuoting some so-called ancient wisdomI could iron out all of the creasesNip and tuck on my pronounced cheek bonesBut this would mean erasing my journeySo I might never find my way homeAnd none of these things in any caseWill ever change the person that I amOr influence the mood of the othersLike a timely facial expression canFrom limbic system to nerve and muscleTo the countenance conveyed on my faceSo complex that even Mona Lisa's moodTook over four year
Beautifully Flawed Wild AnimalsAs a child I was kicked by a horseWhile approaching from behindIt knocked me clean across the stableThis fragile framed boy of nineI tried so hard to be strong and braveAnd as Mother wiped my tears awayAll I could think was I must returnTo the stable the very next dayI barely slept a wink that nightFor thinking about the steedAnd how the doctor said I'd be deadIf hoof had hit below my kneeRunning my hand over the horseshoeThat was bruised onto my thighI felt a very real connectionBetween the animal and IMother woke me as dawn brokeAsked if I still wanted to goTo visit the scene of the crimeTo visit my equus foeI nodded bravely and forced a smileAnd with that we were on our wayI recognised the farmers sonI recognised the bales of hayAnd there he was right in front of meHe seemed bigger than beforeBut there was no fear in my heartJust a sense of wonder and aweThe farmers son took me by the handAnd as he tended to its maneHe fed the horse a sugar cubeA
CryingEverywhere I go I see her faceI never got to touch her soft skinTell me how can I mourn the endingWhen we were yet to even beginAnd please don't you tell me to move onYou really think that I'm not trying?In truth all that I want right nowIs to get through a day without crying
Target WeightI am afraid because I knowThat I will never arriveAt a point where I am nourishedAnd emotionally satisfiedSo to regulate my moodI consume levels that disgraceThey suppose that this is greedThat assumption is misplacedI'm addicted to the feelingThe short term stimulationBut that only makes me more proneTo those feelings of deflationAnd stomach cramps and painsLoose skin hanging from my bonesEyes sinking into my skullAnd those deathly grey skin tonesWill I ever fill the holeSilence those voices for a whileI prepare my gut for sorrowWhile I am spoon fed on denialBut life's too much to digestAn acid reflux episodeRegurgitate my memoriesBefore my stomach explodesIn a culture such as oursThe blame lays nowhere but my plateI chose the fats, sugars and saltsThe impossible target weightNow I'm afraid because I knowThe end has already arrivedIn the form of this addictionTo a staple we need to survive
In Love, I RemainI hold the guitar against meBut I'm afraid it just wont doNo notes that I play could compareTo the symphony that is youSo who is the orchestratorOf this harmonic eleganceThe beauty of which sustains meWith such a lasting resonanceAngels, please sing us a chorusAnd paint the clouds so silver linedMay she always dream in colourAnd may I always speak in rhymeOne single whispered word from herAlways seems to eclipse my painWith belief, hope and destinyForever in love, I remainI hold the paintbrush in my handUntil creative thoughts will ceaseBut no strokes could ever come closeTo your beautiful masterpieceEach colour is so delicateSo rare and so understatedFrom a birth and a blank canvasTo potential God createdAngels, please sing us a chorusAnd paint the clouds so silver linedMay she always dream in colourAnd may I always speak in rhymeOne single whispered word from herAlways seems to eclipse my painWith belief, hope and destinyForever in love, we re
Free Your Mind, Lose ControlPut down all of your booksOpen your troubled mindLeave the cell-like classroomAnd feel the warm sunshineBeating down from aboveOn your beautiful skinForget all you have learntLet your journey beginBreathe the air on green hillsOpen eyes to blue skyThey tried to hide the truthBut with no alibiAre you just a productOf wistful memoriesOr is there still some timeTo change your destinyTether your torrid thoughtsSilence those languid wordsThat pollute your young mindInstead choose to observeThe beauty that surroundsNature is your motherWisdom is your fatherCreation your loverThe world outside your doorCan be a hollow placeDividing us through fearOf religion and raceWhy not come togetherAs beyond our skinWe can live foreverThrough our beauty withinMove forward with one loveYour untouchable soulFor once in your life, friendFree your mind, lose control
Valentine's Day? UGHA blood-colored box in the shape of a heartWhat an ironic way to express a poisonous dartWell perhaps that might be the best wayTo also show how love doth decaySo here I stand with my little red boxCrimped firmly shut with bleeding locksDigging a grave with a blackened spoonI bury this trinket under the glow of the moonNo love for me, not for even one daySo to all I whisper: screw Valentine's Day.
Burnt LoveDo not believe those silly liesOf happiness and sunny skiesWalking along happy as can beLove will strike you blind you seeFor a little while you will rejoiceThinking your heart has made its choiceThen reality will slither your wayAnd hell will become your normal dayLove is nothing but shattered glassSharp and ready to rip your assDon't be stupid you silly foolRun like hell from this deadly duel
Secret WordsI know you need help.It's so plain to see.Please don't hurt yourself.You can count on me.I'll hold you when it's tough,wrap you up tight.I know life is rough,but I'll be your light.I love you, I do.You're everything to me.you don't believe it's true,but I want to set you free.I'll be your rockwhen all your strength is gone.I'll be your lockwhen everythings gone wrong.So please don't cry,my love, my life.I know you want to die,but I'll help you through the strife.Because I'll be there to catch youwhen everything falls apart.I love you, it's so true,with all of my heart.
Blizzard of the WolfIce and snow hiss loudly as they blendWeaving snakes over the river bendThe willow weeps in snaps and cracksBeneath which the wolves run in packsPaw prints vanish beneath the snowAs the howling wind continues to blowUnder the full moon's bright savage glareNothing but white is seen everywhereA black shadowed wolf raises his regal headAnd sings to the pack that he has ledThis mournful howl blends with the nightUnder the blizzard's scream of pure delight
PleaseI want you to love meA little like I love you.Like lovers kissingFor the first time thatIt sets the world on fire.And I plan to burn downWith it because I keep failingTo realize that I'm more thanJust a body for you to touch,A body for you to hold.You arms around my ribsMakes me feel so fragile,But so safe that I could notPossibly break while youContain me.And I can feel you hand slippingFrom mine even though I begYou to stay because I hateThe word goodbye and howYou look as you walk away.Please,I want you to remember meWhen you arrive.And I want you to remember meWhen you leave me behind.
HateYou hated me so much that now I hate me too.You succeeded are you fucking happy? There's nothing left of me to love or save yet your son is still trying, still standing there. We can't see each other but he's the only thing keeping me alive and you don't care.I want to go to somebody anybody and tell them how much I hurt and cry and cut and how it gets me nowhere. I want this to be better. I want you to stop hating me, judging me and lying."I'm not trying to sabotage your relationship"You won't let him see me other than school, let him out of the house except for work and school and you may as well take his phone away too.I feel like we are sabotaged. I feel alone and numb. I feel dead inside.Do you feel fucking accomplished? You destroyed me! You can say I ruined your honeymoon all you want but you ruined it. You looked through his phone; you invaded his personal life by looking at our conversations. Maybe if you'd looked back further you'd have seen I was numb, I was depressed
SecretsSecrets hidden far awayNo needle can draw them forthNo knife can cut them out Secrets under lock and keyNo ear can hear them nowNo lips can speak them aloud Secrets never conceived ofNo judge can jail them allNo one can find them... please.
House of MirrorsThey say I spina web of lies,but webs are for spiders.They catch their flies.No, my lies are mirrors,each a different reflection.They fill up my house,my sinful collection.Sometimes I get lost.There's so much confusion.Which ones are real?Which are illusions?I try to back track,but the mirrors turn me around.I cry out for help,but the mirrors block the sound.I give up.Hang another mirror.In this one I'm cruel and coldon the exterior.How many reflectionswill I become?Which one is real?Where have I gone?
The End of the WorldI'm tired of hearing"Its not the end of the world"That I need to cheer upThat "she's only a girl"But these people don't knowThat I've tried to move onBut these feelings won't goI don't like faking a smileWith every "Hello"But goodbyes are the worstEvery time I feel like I'm cursedI know that I overreactedWhen you said that I wasn't your firstBut you liedAnd that's when I realizedThat what I thought was divineFor you was just another timeInside It felt like I'd dieI was enraged and I criedBut now that I've lost youI'd die to again say that you're mineSo please look at me nowSay that we'll make it somehowThat you'll love me with allthat your heart will allowPlease say you'll come backThat we'll get back on trackThat you'll come to meBefore my heart completely turns black
What Lovers DoWhen I was lost you found meSo now you're lost let me find youFall into my arms sweetheartNo questions, it's what lovers doCradled in my arms tonightTill the morning after ensuesMaybe then you can see thingsFrom a different point of viewWe can sit here all night babeI'm no saint to offer guidanceJust some whispered words of loveI'll be here when you break your silenceThere is no doctrine of lifeBut only second hand wisdomEach person is their own jailorAnd inmate begging for freedomSome of those are there by choiceOthers will just misplace the keyYou are indeed the latterBut please know you can rely on meMay this torrid time tick awayThis is no requiem to our loveAs I refuse to mourn the endOf you, of me and of us
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text:
- Aster C Linn
- Port Alfred
- South Africa
Independent Investigative Researcher and Reporter,
This conversation is closed.
The Communist Takeover of America - 45 Declared Goals ("that found their way down the halls of our great Capitol back in 1963*").
Have you read this article? If not - see: http://rense.com/general32/americ.htm
Topics: Communist China
Showing single comment thread. View the full conversation.
Oct 1 2012: Hello Everyone (I'm sorry I cannot reply to you directly Chen, but it appears your "reply" button has been turned off).
If I may, I would like to introduce myself as a born and bred South African citizen, who has been ("living" i.e. a misnomer) struggling to survive under Socialist/Communist (so-called) "governance*" (*not that I need, want, invite or welcome, any other private citizen's "governance" over me) in the (so-called) new, democratic South Africa for the past 18 years.
And, that said, on to vital issues, namely: where I come from, i.e. my cultural background - the "unnatural" death of ONE (unarmed and defenseless) man, woman, child or infant; no matter their race or skin-color; let alone the "unnatural" deaths of hundreds of thousands (or millions) of men, women and children; at the hands of a maniacal murderer (or many maniacal murderers) is ONE death too many!
And, therefore, as this planet, Earth - the "jewel and apple of God's eye" - has been drenched in the blood of (billions of) human beings (and animals) for the past 200,000 years - one can only wonder WHO is behind this? The "perfectly and essentially morally good Creator of All Creation - Love?" Or the (God-created man, animal and life-hating) Anti-Christ and Father of Lies? Obviously the former.
And WHO in this day and age represents that, but The Godless and loveless (individual-freedom-hating; slave-driver; parasitic leech; confidence-trickster; user and abuser; mass-murdering) Socialist/Communists.
And in the understanding that "none of us are alone in this*" (*as though South Africa, or South Africans are a species apart, who live on another planet!).
See the "glorious and noble" aims that the (undercover) South African Communist Party has for the minority and majority of South Africans* (*who have no wish whatsoever to subsist and/or to "starve to death" under the "ruler-ship" of the "manual workers" in South Africa) here:
Showing single comment thread. View the full conversation.


text:
George Allen Russell (June 23, 1923 – July 27, 2009) was an American jazz pianist, composer, arranger and theorist. He is considered one of the first jazz musicians to contribute to general music theory with a theory of harmony based on jazz rather than European music, in his book Lydian Chromatic Concept of Tonal Organization (1953).
George Russell
Jazz Library - George Russell
An interview with composer and theorist George Russell, reviewing his career higlights.
This entry is from Wikipedia, the user-contributed encyclopedia. It may not have been reviewed by professional editors and is licensed under an Attribution-ShareAlike Creative Commons License. If you find the biography content factually incorrect, defamatory or highly offensive you can edit this article at Wikipedia. Find out more about our use of this data.
Links & Information
- Official homepage at georgerussell.com
- Wikipedia article on George Russell (composer)
- Last.fm page on George Russell
- Discogs at discogs.com/artist/80613
- MusicBrainz entry on George Russell
Links & information come from MusicBrainz. You can add or edit information about George Russell at musicbrainz.org. Find out more about our use of this data. The BBC is not responsible for the content of external sites.


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Congratulations! Your son or daughter is a Penn State Altoona student!
You have spent the past eighteen years or so preparing your child for this next important stage in his/her life. You have taught your teen essential life skills, such as how to make good decisions that will help them to succeed in college.
Chances are high that your son or daughter will be faced with the decision whether to use alcohol and/or other drugs while they are attending college. The truth of the matter is your son/daughter had to make these choices in high school. And, most likely you have had many discussions about alcohol and other drugs with your son/daughter.
We hope you will continue these discussions with your student BEFORE he/she arrives at college and DURING the time he/she is in college. Studies show that parents continue to exert significant influence on their college student's decisions, especially in regards to alcohol and other drug use.
Please note—evidence suggests that the first 6 weeks of the first semester are critical to a first year student's academic success. Some students initiate heavy drinking during these early days of college and this may interfere with a successful transition to campus life.
The following are helpful guidelines:
The Counseling Center is staffed by licensed counselors who provide both individual counseling and case management services. The Center's staff is dedicated to assisting students in their pursuit of personal and academic growth, to help students gain a better understanding and appreciation of themselves, and to support students as they make important decisions about their lives. Contact the Health and Wellness Center at 814-949-5540 to schedule an appointment or schedule through the Online Student Access secure portal.
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text:
Yesterday saw the kick-off of our very public secret project. Yes we love to be innovative here at the SWBN and this project falls squarely outside of the square.
Here is an excerpt from the project scope document that was publicly posted yesterday.
We have also posted graphics of the base numbers for this project as our starting point.
Anyone who has a business/niche area should probably follow along. After all community/tribe building is the hot topic these days (actually has been for ages).
Case study
I have been involved in several community building exercises in the last decade and a half. Here is an example of one.
In 2001 I was one of the "founding members" of a niche PC magazine community. The community progressed the way that most do.
- First there is the common interest that draws people to one place
- Because of this common interest there was acceptance of all kinds of people and personalities
- People started meeting offline very early in the formation, further cementing bonds
- Collaboration spontaneously occurred in all areas – business, creative, philanthropic etc
- Relationships formed ( I met my partner there!)
- The community grew to a size where groups within groups formed
- A self perpetuating entity continues today, with a new generation of central figures
These are the things that will happen in any community (and I bet you could grab any number of studies by sociologists that will confirm that). These will be the milestones we will be looking for in the SWBN comunity.
This may sound cold and contrived, it really shouldn't be though. These things will happen naturally in the right environment.
In the background of the community a core network of dedicated leaders set the norms, had a heap of fun, and did what they saw as what was best for the community.If you have "super fans" like these, hang on to them and encourage them all you can. It is these people that will help your community grow and mature.
This is where interest in your area of business is essential. if you have a business or membership site and you aren't really "into" the whole thing, well people are going to know. It is best in that case to seek out those "super fans" really early and get them doing the communication, bonding and driving. Again, select them and reward them well, your community depends on them.
Back to our secret project, it shouldn't be too hard to track down. I didn't really smudge too hard, and others will have seen where the material is being posted. Seek it out and see what happens.


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We are just three days away from the release of the second season of the highly acclaimed Netflix Original Series House of Cards. Earlier today, Netflix unveiled the final three trailers for the series' second outing.
Now, there is both good news and bad news regarding the series. The good news is that in typical Netflix fashion, the entire season will become available at the same time. However, on the flip side, we will have to somehow make these episodes last until 2015 when Season 3 will be unveiled. If you are anything like me, you have a habit of binge watching your favorite shows on Netflix, so making things stretch can be a little challenging at times.
In the first trailer, entitled "Welcome Back," we watch as Frank, who is played in the series by Kevin Spacey, is being sworn in as the Vice President. He calmly explains that for those of them who are rising to the top of the food chain, there can be no mercy. We all know how ruthless Frank can be, but the real question is, does he have a limit?
The second trailer highlights the trials and tribulations of Frank's wife Claire, who is played in the series by Robin Wright. She has certainly made a lot of sacrifices for Frank over the course of their relationship. Will her dedication be rewarded, or will everything blow up in their faces?
"What you're asking is just shy of treason." She says. "Just shy, which is politics." Frank says.
House of Cards will return for Season 2 on Friday, February 14thon Netflix.


text: Call it better than The Shield, call it a TV phenomenon, call it the next great American novel. Whichever way you swing at it, The Wire's epic police drama continues to evolve with a scope, richness, complexity and ambition unrivalled by anything on the small screen. Four brutal, bittersweet seasons in, creator David Simon shuffles his phonebook cast-list to bring back old characters with fresh slants. Amoral cop McNulty (Dominic West) drops to the sidelines, letting former Major Crimes man turned schoolteacher Roland Pryzbylewski ( Jim True-Frost) go front and centre as Simon pulls Baltimore's stumbling school system into his sweeping, multilayered city portrait of drugs, politics, cops, race and poverty. Extras don't overspill, but what's here is all meat. Six episodes boast talky chat-tracks by Simon and cast 'n'crew, plus a one-hour double-doc gives insight into the weight of research trucked into every episode.


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McAfee products and other security programs such as Norton are very difficult to be removed completely from computers. That is, even though you think you have uninstalled it completely, some of its components still remain in the installation folders. Worse, when you try to install some other antivirus onto the computer, you will be promoted that you already have McAfee installed and cannot install other programs. So, how to uninstall McAfee completely & easily?
Uninstall McAfee through Add/Remove Programs
In many cases, you can simply remove McAfee products through the Control Panel, Add/Remove just like uninstalling other programs from the computer. To do this, you can simply follow the steps below:
1) Go to the Start menu and click on Control Panel.
2) Double-click the Add or Remove Programs to open it.
3) Find the McAfee product listed in the currently installed program list and click on it.
4) Click on Change/Remove to go.
5) You'll see a screen appearing to confirm that you want to uninstall McAfee or cancel it.
6) Click Remove and follow the on-screen wizard to continue.
7) Reboot your computer if asked when the uninstall finishes.
If for some reasons, the normal McAfee removal job does not remove it, I recommend you follow the automatic uninstall instructions below to remove the program from your computer. The uninstall will come to failure if you still find the antivirus program launches after a system reboot or find some of its related files on the PC.
How can you uninstall McAfee completely?
A much easier and safer way to uninstall McAfee is to turn to a third-party uninstaller program, for example, Perfect Uninstaller. Such tools are specifically designed to completely uninstall programs both from the hard disk & registry database. The Perfect Uninstaller is one of the best programs available on the market as its Force Uninstall feature can deal with any corrupted programs that cannot be removed via the normal channels. If you are not familiar with computer or editing the registry and unregistering DLLs, this will be your best bet to uninstall McAfee and other programs from the computer.
Check out what else this program uninstall tool can do for you Believe me; after downloading and installing it on your PC, you will be able to completely remove any problematic software at the click of a button.


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'Fabulous little lightweight item'
Mum of Panda - Scotland
'I started off with plastic hooks and they snapped with the weight of a bag of shopping and in cold weather.'
Debs - Glasgow
'Very happy. Quick delivery and easy to put on to the buggy.'
Alida - London
'Easy to use'
Michelle1812 - County Durham
'I use the buggy board for short walks with my three year old (and one year old in the buggy) it has meant...'
Sarah - London
'Ordered item in the afternoon. Couple of hours later received a dispatched text. Couple of ours after that...'
Pj - Cheshire
'Those clever people at Babystyle have added this wonderful addition to its award winning Oyster...'
Kiddicare Staff Expert - Peterborough Cambs
'This cup holder is the perfect addition to your oyster pushchair, simply clip onto the stroller handle to...'
kiddicare staff expert - peterborough cambs
'I use this product on my sons pram to keep him cool when the weather is really hot. He loves the birdy...'
Yummy Mummy - Merseyside
'Suitable from birth - 15kg'
Kiddicare Staff Expert - Peterborough, Cambs
'All good'
Bumps Gdad - West Midlands
'Perfect for everyday use and especially on those enjoyable long walks by the river when you have 4 kids!'
Monkey - Cheshunt, Herts
'This tray is designed to fit your Vista and will make snack time easier. Simply attach the tray to your...'
Kiddicare Staff Expert - Peterborough Cambs
'Great product at great value. Bought this to make my life just a little bit easier when out shopping with...'
Gemelos2008 - Berkshire
'nedded to take abroad to fully cover pram for insects most net are a tight fit on the prams this was ideal'
working nan - hartlepool
seed1999 - Waarington


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Creating a Memory Book - Video Tutorials #genealogy
Create a Memory Book in Shutterfly (Tutorial 2): via @YouTube
Creating a Memory Book in Shutterfly (Tutorial 1): via @YouTube
Creating Memory Books on Shutterfly #genealogy
Sharing Memories (Week 50): Memories of Santa #genealogy
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Archive for September 21st, 2014
Lenovo 09143AU IdeaPad Z560 15.6-Inch Notebook – $594 + $0 Shipping
COUPON EXPIRES 7/14. Lenovo has an awesome, even lower price on their Lenovo 09143AU IdeaPad Z560 15.6-Inch Notebook. This laptop's specs: 15.6-inch 366x768 LED display, 2.26GHz Core i3-35om CPU, 3GB ram, 500GB hdd, wireless, b...
Logitech MX 5500 Revolution (920-000383) Bluetooth Cordless Desktop Keyboard & Mouse Kit – $90 After Rebate & Coupon
COUPON EXPIRES 7/15. Newegg has a sweet combo deal on the Logitech MX 5500 Revolution (920-000383) Bluetooth Cordless Desktop keyboard & Mouse Kit. This set utilizes a Bluetooth connection , has 102 keys, is powered by 2 AA...
Solar Power
Top 10 Coolest Solar Vehicles
Solar? Yes please. Only if there was more of it and it was more efficient. This is our list of the top 10 coolest solar vehicles to date. Some are practical, some down right expensive and others straight up wacky. But wha...
Amazon Deals
Samsung YP-P3JCB/XAA Palm Theatre Plus 8GB MP3 Player – $125 Shipped
Amazon has an awesome price for the Samsung YP-P3JCB/XAA Palm Theatre Plus 8GB MP3 Player at $124.99 with free shipping! This player has 8GB of storage, video support, Bluetooth 2.0 connectivity, touchscreen , a built-in speak...
D-Link DGL-4100 Gaming Router – $60 + Free S&H
Newegg has the web's best price by far on the D-Link DGL-4100 Gaming Router. Features include 4x 1000Mbps Ethernet inputs and Game Fuel priority technology for an optimal gaming experience. It's (more…)
6ave Deals
Panasonic SC-BT303 Blu-ray Disc Home Theater Sound System – $334 After Coupon
6ave has the Panasonic SC-BT303 Blu-ray Disc Home Theater Sound System for a web's best price. The system includes a built-in Blu-ray player and iPod Dock, 7.1 channel surround sound, a dedicated subwoofer, VEIRA Link, 1080p pl...
BuyDig Deals
Samsung LN-40B550 40-Inch LCD TV – $675 Shipped
Buydig has an amazing price for the Samsung LN-40B550 40-inch LCD TV. This set has a 1920x1080 resolution, built-in HD tuner, 70,000:1 dynamic contrast ratio, 6ms response time, and 4 HDMI inputs. It's (more…)
Sharp LC-42SB48UT 42-Inch 1080P LCD HDTV – $599 After Instant Savings
Dell Home has awesome instant savings today on the Sharp LC-42SB48UT 42-Inch 1080P LCD HDTV. It's got a 1080p resolution, 450 cd/m² brightness, 26,000:1 dynamic contrast ratio, 4 hdmi inputs, 6ms response time, and more. It's (...
Garmin nuvi 1350T 4.3-Inch Widescreen Portable GPS Navigator w/ Free Screen Protector – $140 After Coupon
COUPON EXPIRES 7/16. Today brings a sweet coupon price on the Garmin nuvi 1350T 4.3-Inch Widescreen Portable GPS Navigator. This GPS has a 4.3-inch touchscreen display, traffic ready, spoken street names, ecoRoute, City Navigat...
Samsung Spinpoint M7 HM641JI 640GB Laptop Hard Drive – $65 + Free S&H
COUPON EXPIRES 7/15. Newegg offers a sick price on the Samsung Spinpoint M7 HM641JI 640GB Hard Drive. It's got a 640GB capacity, 5400 rpm drive speed, 2.5-inch form factor and more. It's (more…)
Onkyo HT-S5300 7.1-channel Home Theater System – $400 + $0 Shipping
COUPON EXPIRES 7/11. Newegg has a web's best price for the Onkyo HT-S5300 7.1-channel Home Theater System The system includes 7 surround speakers (2 Front Speakers + 2 Rear Speakers + 2 Surround Speakers + 1 Center Speaker + 1 ...
Abes Of Maine Deals
Sony HDR-CX350V 32GB Flash Memory HD Camcorder – $675 + Free Shipping
Abe's of Maine has lowered the price even further for the Sony HDR-CX350V Flash Memory HD Camcorder. This camera has built-in 32GB flash storage, full HD resolution, a 2.7-inch LCD, face detection, memory stick and SD card slot...


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Our Cabernet Sauvignon showcases fruit and spice components in a smooth, supple style. Forward aromas and flavors of cherry and berry are enhanced by delicate chocolate, clove and oak complexity leading to a round and elegant mouthfeel.
Camelot embraces California's bountiful viticultural riches:
its many world-class winegrowing regions, ranging from the Central Coast, with its alluvial soils and marine-influenced microclimates, to the warm, hilly expanses of the historic Sierra Foothills Gold Country.
They carefully research these areas to identify their best grape varieties, then source fruit from outstanding...Read More About Camelot
The largest of California's wine growing regions, the Central Coast produces the majority of California's wine. The district sprawls out, covering most of the vineyard land between San Francisco and Santa Barbara. Smaller sub-AVAs of the Central Coast include Monterey Bay, Paso Robles, Santa Ynez Valley, Santa Maria Valley, Santa Cruz Mountains and many others. Notable Facts...Read More About Central Coast
(cab-uhr-NAY sow-veeh-yawn) King of Red Many refer to Cabernet Sauvignon as the king of red grapes. Perhaps that title is due to its ability to grow worldwide in a number of climates, or to the fact that it produces wine with such character yet such diversity. Either way, this grape is responsible, as a whole or a partner, for some of the greatest wines in the world. In Bordeaux,...Read More About Cabernet Sauvignon
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wualta- i can barely remember anything from the '70's :)
i do remember the sennheisers had yellow foam earpads, and they weren't very expensive and they didn't last very long, but sounded pretty good. the hp-1's were a lot better sounding but if i remember correctly they took awhile for my ears to get used to the fit. and they were pretty expensive- maybe $110 at the base px. i went through a phase where i kept upgrading speakers as they became available at the px, but i only bought the sennheiser and yamaha headphones.


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On the new 3,560-passenger Royal Princess, there's one area of the ship you should enter at your own risk. No, we're not talking the engine compartment, but the pastry shop, a 1,100-square-foot room devoted to decadent deliciousness.
Head pastry chef Eric LeRousic and 19 pastry cooks create a rotation of 130 sweet treats. At the "action stations," you might see one of them dipping strawberries in chocolate, torching crème brûlées, or pulling fudge.


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- Mats Kaarbø
- Bergen
- Norway
This conversation is closed.
Implementing a Star Trek Economy
Implementing a global holistic Star Trek economy, here on Earth, that is based on the needs of mankind and not the acquisition of wealth. Where our incentives would lie in bettering ourselves and those around us. Where we would live beyond the need for money, politics, poverty, war, national border and social stratification.
Through technological abundance and automation of labor this is not just feasible, but rather easy to attain. And with an educated population the transition to such a society would be much smoother when the predicted economic collapse, which is seemingly looming upon us, breaks out.
With that, I hope for a healthy and fun discussion on this topic and sharing of many other great ideas that can help build a better future for us all. LLAP.
Showing single comment thread. View the full conversation.
Sep 7 2012: People do their jobs so that they can can earn their living.money is just a concept that was created so that the resources are utilized properly,but now people feel money itself is everything.even if u have trillions and trillions of dollars or whatever currency what will you do with that if the natural resources are dead?? the earth is free.nobody has the right to own it .and whats the point of having this economic race when we know that the earth is a lone planet in solar system.shouldn't every body in the world be educated and given equal rights and facilities.in corporate sectors there is constant tug of war for power.what do you gain from wars and the arms race.having armies and weapons just indicates that every country is just waiting for a war to happen.the earth is not owned by anyone so why aren't people allowed to move freely.why the racism.why just don't believe in science and stop wasting your time with religion and divide people according to cast, color,race,country etc
instead of many companies being in a race for launching a better product why can't there be a single firm for everything so that we don't waste the resources.scientists should work on enhancing the human body so that we can create more stronger,intelligent beings.
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Milk Tea Mochi at Mochiko
+ really tastes like milk tea!
- mochi is a little bit too thin
- expensive:(
Bak Kut Teh of Makan Makan
+ good taste, herby but does not have the strong star anise taste i hate
+ ribs are tender
- uses teabag herbs for the broth, no actual herbs served
Taro Pudding Milk Tea at Cha Time
+ pudding tastes ok and adds a nice texture to the drink
- doesn't come with pearls, need to add additional, but i think its better with pearls
- taro is too grainy and artificial-tasting for me
- taro in quickly tastes better
Taro Red Bean Milk Tea at Cha Time
+ i like the combination of red bean and tapioca
- the taro makes the drink grainy/powdery
- tastes artificial to me
- quickly taro tastes MUCH better
Pearl Milk Tea at Cha Time
+ just the right balance between tea and milk
+ one of my favorite drinks at Cha Time
+ no frills, smooth milk tea drink with tapioca
Tapa at Somethin' Fishy
+ available inthe midnight to morning buffet
+ very thin slices of beef with a bit of fat
+ marinated well.. Very tasty. Especially good with some vinegar
Hiyashi Tanuki at Jipan
+ my favorite cold soba ever
+ very refreshing taste
+ sweet tempura sauce-like dipping sauce
- sometimes served with udon.. Dont like it very much like that. Prefer the thin noodles
Spicy Fresh Tuna Salad at Jipan
+ i love spicy raw tuna
+ tastes good, not as spicy as i like, but you can easily add a dash of chili to add spiciness
- serving is very little compared to Sakura
- Sakura's spicy tuna salad is waaay better
House Special Earl Grey Tea at Gong Cha
+ rich tea taste
+ yummy 'rock salt and cheese' ish topping
- taste a bit bland if not mixed well with the topping, so topping is a bit 'bitin'
Kumquat Lemon Juice at Cha Time
+ refreshing drink ('calamansi')
- a bit bitter for my taste, lacks sweet that goes well with citrus drinks
Honey Lemon Aloe at Cha Time
+ good mix of sweet and sour
+ aloe bits give a unique flavor and texture
+ refreshing! My favorite non-milk tea drink at cha time
Pork Barbecue in Skewers at Lemongrass
+ super tender meat
+ tasty!
- garlic rice is just so so
Handmade Taro with Fresh Milk at ShareTea
+ yummy taro taste
+ best fresh taro milk i've tried
+/- too 'pulpy', too much taro bits
- a bit more expensive than the other drinks
QQ Happy Family Milk Tea at ShareTea
+ with lots of toppings: pearls, grass jelly, pudding, red bean and lychee nata (my fave)
- the taste is not so strong
Ancient Chinese Sticky Misua (Dry) at Lemongrass
+ one of the best tasting misua i've had ever
+ lots of toppings - bbq meat, shrimp, shallots, egg
+ unique sticky misua
- serving is a bit small especially for the price
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Alicia Key rocked some interesting shoes during her performance at the 2010 World Cup opening ceremony.
We gave you the performance earlier this week but didn't notice these crazy shoes on her feet! Check them out:
Are these hot or is she going just a little too far? She even tweeted a joke about her "bony feet".
You tell us in the comments section!!!
While you're here, check out some more photos of Miss Keys below:
Alicia Keys' Best And Worst Looks
http://ionehellobeautiful.files.wordpress.com/2010/06/alicia-keys-portraet-29431.jpg?w=180&h=180&crop=1 http://ionehellobeautiful.files.wordpress.com/2010/06/alicia-keys-braids-hg-de1.jpg?w=180&h=180&crop=1 http://ionehellobeautiful.files.wordpress.com/2010/06/alicia-keys-11.jpg?w=180&h=180&crop=1 http://ionehellobeautiful.files.wordpress.com/2010/06/alicia-keys-and-swizz-beatz-2-344x4781.jpg?w=180&h=180&crop=1 http://ionehellobeautiful.files.wordpress.com/2010/06/alicia-keys-and-swizz-beatz-325x4782.jpg?w=180&h=180&crop=1
Swizz Thinks We Believe He & Alicia "Will Make A Great Family"


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1hr 46min
Synopsis: Edith runs a left-wing journal and when her marriage starts to fall apart (her husband is unfaithful), she can find no solace in her son who is more of a problem than an asset. On top of heading toward a divorce and being unable to handle her son's asocial tendencies, her neurotic uncle moves in, demanding personalized care. Just to keep her sanity intact, Edith starts writing in her diary to vent her own feelings and ambitions. As her son goes from bad to worse over a five-year period, it turns ... Full Synopsis


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Chris Cantore
Thom Yorke (of Radiohead, shown here at Coachella in 2004) will performing at Coachella in 2010.
The Coachella Valley Music and Arts Festival -- or Coachella -- is a three-day music and arts fest held at the Empire Polo Fields in Indio, Calif.
Personally, I've been attending the fest (annually) since 1999, the inaugural year of the event, when Beck, Morrissey, Tool and Rage Against the Machine performed.
Every year, I liken the Coachella lineup announcement to Christmas as a kid. You have your wish list, hopes are high, and rumors circulate as you anxiously await the big day. This year, Santa delivered the goods. Here are some of the highlights:
Coachella's Web site has a full lineup listing, ticket information, hotels, camping info and directions.coachella.com/


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When a pol angers those already opposed to him or her, it's not a big deal. But to alienate supporters or those who might be supportive is a big mistake. Rick Santorum made a big mistake by blasting ObamaCare for "requiring health-insurance companies to cover certain prenatal tests, because some procedures are used to identify abnormalities and "encourage abortions." (Read) Santorum's also wrong on the issue.
The Republican presidential candidate is correct that the results of prenatal tests, when they uncover abnormalties or health risks, can lead to decisions to abort. But that's a consequence of a needed health option for parents and the unborn baby. Knowledge, and options for treatment are the reason prenatal testing needs to be covered. I have empathy for Santorum and his wife, who have dealt with one child, Gabriel, dying shortly after birth and are also raising a child, Isabella, with "Trisomy 18, a chromosome disorder that often results in stillbirths or early childhood death." (Read) My wife and I have a son who died 24 hours after his birth. He was diagnosed, through prenatal testing, with hypoplastic left heart syndrome. At the time, a doctor recommended to us that the pregnancy be terminated.
We never considered abortion as an option, but I never felt any offense at the suggestion. As it was, our son, Ray, was delivered, loved, and died peacefully. Personally, it's time I treasure, and I'm glad we provided him life.
Santorum's opposition to insurance providers being mandated to cover prenatal testing, just because it might be used for a later abortion, is not enough of a reason, religious or otherwise to deny parents who are extremely worried about their unborn child the peace of mind of an amniocentesis, or other prenatal testing. To follow Santorum's logic is to deny people access to advances that can improve human life. That's an extreme position; as a result it can drive potential supporters away.


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News and Articles About Intrapreneurs
Inspire Innovators to Step Up at Your Company With Transparency
Fostering intrapreneurship within organizations both large and small can help bring companies to new levels of success.
Mid-Market Businesses Grow With the Right Hiring
The nation's 200,000 mid-sized business are an engine of economic growth fueled by talent nurtured to innovate.
4 Reasons Why Leaders Need More Wave Makers
These innovators jump in and ask, What can I do? and initiate changes that can bring huge payoffs to an entrepreneurial operation.
Entrepreneurs Need Intrapreneurs to Make Their Company Great
The person who has all it takes to build their own company is the employee you need to help build yours'.
Want to Change the World? Maybe Try Being an Intrapraneur.
Working as an innovator inside a company, especially in the environmental field, can yield satisfying results, says an insider.
5 Must-Have Skills of Intrapreneurs Inside Their Grown-Up Startups
Great entrepreneurs don't have to sell and start over once their businesses hit it big. Instead, they can transform themselves into intrapreneurs.
You've Been an Intrapreneur. Are You Ready to Unleash Your Inner Entrepreneur?
Find out the difference between the two roles from someone who has started a venture as his own company as well as worked on startups within firms.
My Mentor Is 30 Years Younger Than Me (and Taught Me 5 Incredible Lessons)
Valuable lessons sometimes come from unexpected sources. Learn to listen to those around you and take a break from technology addiction.
Keep Your Employees Loyal By Encouraging Them to Pursue Their Own Projects and Passions
Allowing corporate employees to experiment with entrepreneurship promotes innovation and keeps employees satiated, though a few of the most ambitious may jump ship and start their own ventures.
If You Want to Keep Rockstar Employees, Set Them Free
There is a new 'company man' culture brewing inside brands that want to maintain their cutting edge, according to David Armano, managing director at Edelman Digital.
Why Everyone Will Have to Become an Entrepreneur (Infographic)
From those doing manual labor to those in the C-suite, workers of all kinds are facing more pressure to embrace an entrepreneurial way of thinking.
3 Things You Don't Know About Intrapreneurship
Fostering intrapreneurs inside your company can boost innovation and prepare the next generation of aspiring entrepreneurs.
If I Knew Then: CEO of Kid-App Maker Toca Boca on Finding Intrapreneurial Success
Bjorn Jeffery delves into why serendipity led to his success in innovation.
What It Means to Be an Entrepreneur Now
Entrepreneur's Amy Cosper talks about the evolving concept of entrepreneurship at the SXSW Festival.
Is Corporate America a Startup?
People are hacking corporate culture. But are they entrepreneurs?
How to Persuade Your Boss to Fund Your Business Idea
Intrapreneurs are launching businesses within -- and with the help of -- their places of employment.
Connect with Entrepreneur
Most Shared Stories
The 25 Tools Every Entrepreneur Should Know About
44 Apps That Turn Your Smartphone Into a Productivity Powerhouse (Infographic)
This Clever Marketing Campaign Reversed Coke's 11-Year Decline in Soda Sales
5 Golden Pieces of Leadership Advice for Young Entrepreneurs
Here's How to Talk to Graphic Designers


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Pubs scmubs! London is buzzing with baristas who know macchiato from ristretto and are luring folks back to the 'cafe'.
When the good people of London aren't drinking pints of beer they are generally drinking mugs of tea. But times are a changing. No longer is British coffee a bitter punch in the mouth, it's smooth, it's creamy and it's everywhere.
According to local barista lore, Flat White is at the heart of London's coffee culture. Since 2005 it's aimed to translate the Australian and New Zealand coffee experience to London – and it's worked. If you're from the colonies then this place will feel familiar; it's small, its music is loud, its baristas wear black and it does a roaring takeaway trade.
Despite Monmouth's formidable local presence, the British roaster's original store in Covent Garden is incredibly humble. Since opening in 1978, Monmouth has built three dedicated cafes, a new roasting base in Bermondsey and a healthy wholesale trade around the country. Word of warning: they only serve Jersey whole milk here, which just means that the coffee is consistently (and deliciously) creamy.
The Espresso Room is small but strong. The tiny café pulls shots from local roasters, Square Mile, to perfection. Grab a takeaway flat white then wander the bookshops and stores on nearby Lambs Conduit Street.
If you do one thing in East London make it a trip to Leila's Shop at Arnold Circus. The clutter free, Polish café is obsessed with simple detail, which reveals itself in both the hearty rye sandwiches and coffee. The latter is made from Monmouth beans and comes 'milky' or 'black'.
Hackney is literally bursting with decent cafes but Climpson & Sons is next level. Climpson hand-roasts its beans a stone's throw from the storefront, which doubles as one of the best places to people-watch in London.
The slightly more refined sister to Flat White, Milk Bar's spacious, boothy interior is a luxury in Soho. Like its sibling, the café uses Square Mile beans and keeps Bonsoy on hand for soya freaks.
Maison d'être roughly translates as "home to be" and the new Islington café feels like a home away from home (if said home is a quaint cottage in Provence). Run by two lovely ladies, the coffee comes from London-based micro roastery Nude Espresso and is paired with sandwiches, scones and treats. Plan to stay a while.
The above cafes are just the start of it. See below for a more extensive listing that includes Towpath Café on Regent's Canal, New Zealand roasters Allpress in Shoreditch, southsiders Bermondsey Street Coffee and Rose Bakery (above Dover Street Market) in Mayfair. Food & DrinkFlat White17 Berwick Street, Soho, W1F0PT+44 2 7734 0370Mon-Fri 8am-7pm, Sat-Sun 9am-6pmflatwhitecafe.com
Monmouth Coffee27 Monmouth Street, Covent Garden, WC2H9EU+44 2 7232 3010Mon-Sun 8.30am-6pmmonmouthcoffee.co.uk
The Espresso Room31-35 Great Ormond Street, Bloomsbury WC1N3HZ+44 7 7607 14833Mon-Fri 7.30pm-5pmtheespressoroom.com
Leila's Shop15–17 Calvert Avenue, Shoreditch, E27JP+44 2 7729 9789Wed-Fri 10am-7pm, Sat 10am-6pm, Sun 10am-5pm
Caravan11-13 Exmouth Market, EC1R4QD+44 2 207 833 8115Mon-Fri 8am-10.30pm, Sat-Sun 10am-10.30pmcaravanonexmouth.co.uk
St Ali 27 Clerkenwell Road, EC1M 5RN+44 2 7253 5734Mon-Sun 7am-6pmstali.co.uk/uk/
Climpson & Sons 67 Broadway Market, Hackney, E8+44 2 7812 9829Mon-Fri 8am-5pm, Sat 8.30am-5pm, Sun 9am–4pm
Maison d'être54 Canonbury Road, Islington, N12UP+44 2 7226 4711 Mon-Fri 7.30am-6pm, Sat-Sun 10am-6pmmaisondetrecafe.co.uk
Milk Bar3 Bateman Street, Soho, W1D 4AG+44 2 7287 4796Mon-Fri 8am-7pm, Sat-Sun 9am-6pm
Towpath Café 36 De Beauvoir Crescent, Hackney N15+44 2 7254 7606Mon-Sat 9am-6pm
Allpress Espresso58 Redchurch Street, Shoreditch, E27DP+44 2 7749 1780Tues-Fri 7.30am-4.30pm, Sat-Sun 9am-5pmuk.allpressespresso.com
Bermondsey Street Coffee167 Bermondsey Street, SE13UW+44 2 7403 7655Mon-Fri 7am-7pm, Sat-Sun 8pm-8pmstreetcoffee.co.uk/bermondsey-st
Rose BakeryDover Street Market, 17-18 Dover St, Mayfair, W1S4LT+44 2 7518 0680Café hours: Mon-Wed 11.30am-5pm, Thur-Sat 11am-5pm, Sun 12pm-5pm
Nadia Saccardo
Melbourne's entrepreneurial class, fresh with cash to splash, are rolling in on new vineyards and restaurants in the Yarra Valley
Qantas Travel Insider provides tips for the discerning traveller, from both savvy locals and the well-travelled. Learn more about us and how you can get involved.


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are you cool man?
are you cool man?
Can't say I don't care, but I don't have the time to stress.
To witness this in real life would be a blessing. (Stephane Vetter)
This picture of the star formation region NGC 3582 was taken with the Wide Field Imager at the European Space Observatory's La Silla Observatory in Chile. The image reveals giant loops of gas ejected by dying stars. (ESO)


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Carl's storage can't dynamically learn and adapt to the needs of virtualized apps, servers and desktops simultaneously. Need to deploy or tear down thousands of VMs? Forget it. That's extra pain.
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Monday, October 6 - 9:00 AM PDT/ 12:00 PM EDT
High Performance
"Compared to our previous storage, Tintri VMstore can accommodate twice the IOPS at less than a third of the latency in one fourth the footprint."
Ease of Implementation
"We started migrating off the NetApp slowly, moving just a bit each day to see how it would run. Once we saw how easy it was to migrate and how well it was running, we moved everything over. The Tintri installation was completely uneventful – in a positive way."
Speed in Provisioning
"In just ten seconds, Tintri can do what the legacy storage system did in eight hours."
Stellar Performance
"Not a single storage solution could outperform Tintri in any aspect of our POC. Tintri left all of the other storage vendors in the dust."