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Greater St. Louis Area Council: Boy Scouts of America
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Parent's InformationMap to S bar F and Camp LewallenYour camp mailing addressVisitor's night information Camp MenuMedical exam requirementsCamp Fees and Refunds
2014 Camp Lewallen Summer Camp Manual
2014 Camp Lewallen Mini Webelos Camp Manual
Hey, Scouts!
Are you ready for a great summer at camp? CAMP LEWALLEN is waiting for you with more activities than you could possibly do in a week.
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Monday night will be the new Spy Voyageur program. This treasure hunt for patrols will begin at the Trading Post. So get ready! Take a look at all the fun that happens . . . and Be Prepared!
Check out these areas:Voyageur ProgramOlder Scout ProgramsOrder of the ArrowYour CampsiteMap of Camp LewallenThe Trading PostEquipment ListMerit BadgesSwim TestSummer Camp EmblemMile Swim
Read: Never a "dead end" at Camp Lewallen

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This August, the UK's biggest food festival is returning to Battersea Park London and food-lovers are invited to enjoy the vast array of culinary activities taking place over the 3-day event including chef demonstrations and food masterclasses. Now in its sixth year, Foodies Festivals also take place across the UK in Edinburgh, Brighton, Bristol, Hampton Court Palace, Tatton Park and Oxford.
The London Perspective has Five pairs of tickets to give away! So you and a friend are in with a chance to see top chefs, including (Mr Reggae Reggae Sauce!) Levi Roots , Ed Baines of Randall & Aubin, Ben Tish of The Salt Yard, Clare Smyth of Restaurant Gordon Ramsay, cook signature dishes live in the Chefs' Theatre and explain how amateur cooks can prepare the same dishes at home.
To win a ticket all you have to do is Like the The London Perspective Facebook page AND leave a comment on this blog saying "I'm the biggest Foodie"
The competition will be closing on Friday 10th August and Winners will be notified by email by Monday 13th August 2012.
Tickets for Foodies Battersea Park are available from www.foodiesfestival.com or by calling 0844 995 1111.


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ROSEVILLE, MI (WTVB) - Authorities are expected to know this afternoon if the soil samples taken from behind a Roseville home Friday morning contain human remains and are worth additional excavation. It's a long shot that the remains of former Teamsters boss Jimmy Hoffa might be there. An anthropologist at Michigan State University spent the weekend studying the soil sample for the local police. The search was prompted by a tip from a former Michigan man who used to live on the same block and said a previous owner of the home, who he called a bookmaker for the Mafia, was up all night pouring concrete the day Hoffa disappeared. The FBI has chased thousands of Hoffa tips since his disappearance in July 1975.
Jay Fox 3:00 PM - 5:00 PM
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72% less sat fat • 43% fewer calories • 61% less fat than the original recipe. A favorite casserole gets a star makeover. Substituting brown rice for white provides whole-grain benefits while reduced fat ingredients trim the fat but keep the flavor.
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Hot Ingredient for the New Year: Elbow Grease
The first pieces of writing of the year are always about predictions, resolutions, hot trends, and diets. I'll be honest: writing about what's hip in food for a particular year is usually an unpleasant and forced activity for me. This year, I actually came up with something to say in an organic way. It's not a prediction; it's just something to think about.
Elbow grease.
During the holiday break, I lost all my routines. One morning, I found myself at home with Ursula scrubbing out the inside of our 24-inch rental apartment stove. The mess inside this oven was the kind of thing not even a toxic spray, steel wool and rubber gloves could tackle without breaking a sweat, but we had some energy to burn.
Of course I elected to do it the "natural way," passing up the can of Easy-Off and instead, making a paste of baking soda, vinegar, and dish soap. The kiddo and I slowly mixed the vinegar into the baking soda to prevent a room full of fizzy foam and scrubbed the inside of our oven to music for at least an hour. Traditional oven cleaners take about as long but you don't have to scrub; I think you are meant to watch television while the chemicals eat away the remains of your meals.
Midway though I realized I was getting some kind of sick joy out of this task, fulfilling both the physical and spiritual needs that are usually filled in the mornings at yoga, an activity I was missing from lack of the sitter. We laughed, we sweated, and we also had moments of focus, quiet and peace, almost like a meditation.
I thought about holidays where a copper bowl of whipping cream went around the table, each person taking a few minutes with the whisk until we had whipped cream for our pie, and how once the stand mixer did the job, that was one less thing to do together as a family. Elbow grease.
Sure, the stove-cleaning project took longer than it would have with chemicals, and it's probably less clean. In this era of instant Google-gratification and the ability to create things that are near-perfect (I'm thinking of everything from plastic surgery to iPhone photo apps) taking a while to complete a task, and being able to settle for it being less than "best" is actually a luxury. By scrubbing our ovens and kneading our bread and whipping our cream by hand we can teach ourselves some important lessons.
This year I'm going to pay extra attention to what I do by hand, and how by doing it I can spend more time with someone (including myself), how I break more of a sweat, how I give myself a few extra minutes to zone out and breathe. Elbow grease will be the hot new ingredient in my kitchen.
Some inspiration from our archives on ways to add some elbow grease to your kitchen:
• The How's and Why's of Whisking By Hand
• Stand Mixer vs. Arm Muscle: Do You Mix by Hand?
• The Key To Creaming Butter By Hand
• 6 Ways to Make Ice Cream Without an Ice Cream Machine
• Tips and Recipes for Making Tortillas By Hand
(Images: Shutterstock/PRILL, Sara Kate Gillingham-Ryan, and Witigonen via Flickr Creative Commons))
More posts in this series
Give Your Kitchen a Fresh Start
34 Comments
While I don't envy your oven-cleaning activities, I find tough cleaning/organizing home projects cathartic. Like a good exercise session, it feels so good when it's done, also. Here's to elbow grease in 2013!
A beautiful, thoughtful post. Although we have a dishwasher, a number of our dishes, pots and glasses aren't dishwasher-safe. So I find myself washing at least some dishes by hand every day. Sometimes, I'll end up taking things from the partially filled dishwasher and washing them in the sink too, for much the same meditative pleasures and sense of accomplishment you describe here.
Admirable indeed! Interesting cleaning recipe too. Hate Easy Off!
Next time knock the grease down with ~GREASED LIGHTNING~ and proceed with your concoction for baked-on brilliance...
You'll still get work out......:-)
I love this physical goal! It goes hand in hand with my decluttering ambitions for the New Year.
I'm a huge advocate of the manual method, *especially* if it can save me one more appliance or unitasker in an already over crowded kitchen. I've also been going the natural cleansers route for a while.
I don't want to be critical, because this is a lovely post, but you shot yourself in the foot a little on the oven project, I believe. Mixing an acid and a base results in water and a salt, which means by the time the fizzing stopped, you were cleaning with dishsoap and water. You could have gone with dishsoap and vinegar, as the initial solvent that broke down the grease, then when you needed an abrasive made paste of baking soda and water, which would be an abrasive to get the hard gunk off. Or vice-a-versa, or anything but pre-mixing the vinegar and water. The fizzing is fun, but it serves no cleansing purpose.
However, yes!, to manual methods, slow food, and the natural way of doing things! Thank you.
correction: "premixing the vinegar and *baking soda*" not water.
I'm aware of that piece of science but I find that if you stir the vinegar in gradually, it makes a paste that is stable - thus the photo of my nasty stove caked with dried white goop. Seems to work. Don't ask me how! I'm just a humble cook...
I find it a lot easier to clean an oven with the door removed. Just lay the removed door on several layers of old towels to clean. Beats leaning over the open oven door.
Overnight temps and longlasting inversion find me waiting for kitchen pipes to thaw!! A hairdryer is propped and blowing HOT air onto the pipes, and I know that patience will WIN...
Tonight the undersink doors stay OPEN, with space heater positioned and ON. Pipes in crawl space are already wrapped with insul tape, however, below ground level, inside 'extended bump-out' where it's COLDer than COLD.
Thanks for your wonderful posts- love them, and have used many! Elbow grease yet another GREAT addition to my collection!
I love your post! And per your last photo, making homemade bread has always been a cathartic labor of love for me. If you can relax and get out your stress while kneading bread dough, you just can't at all! Although everyone in my house agrees, we all gain about 5 lbs everytime bread starts being made. There's just something about that warm yeasty goodness coming right out of the oven, with some real butter. At least we are all gaining together!
Love the elbow grease idea, especially passing a bowl of cream around allowing everyone to mix it.
When I was very young, my friend and I drew on the sidewalk with crayon. Her mom, who was German, had us scrub it off and gave us Comet and rags. I remember telling her we weren't getting it up. She told us to "use more elbow grease" and for years I always associated Comet and elbow grease. I don't think it was until I was in high school that I finally realized that "elbow grease" was a figure of speech.
Love this post! I too spent a morning cleaning my oven over the holidays and had the most luck with using my pastry scraper to get the gunk off the oven door. It was a victorious moment when I could finally see what was baking inside ;-). I was quite proud of myself and it made all my holiday baking so much more fun.
There's something very satisfying about scrubbing out my bathtub with a similar paste. I also spent a long time whisking homemade mayo last week, so I experienced the same satisfaction and meditation through that (along with a sore forearm).
I don't know if elbow grease is all that you say. There is something to be said for "labor saving devices" and chemicals. I like to wrap grills and such in newspapers, put them in a lawn and leaf trash bag with a cup of ammonia, and let chemistry do the work.
My dear wife OTOH has a penchant for pumice, emery paper, and elbow grease. Ruins anything shiny. But it's clean!
I wonder how healthy and strong we might be if everything weren't quite so convenient.
I cleaned my dishwasher with vinegar baking soda combo.. Removing the floor mesh and all the gunk below, took about an hour on a snowy midwest, and got me warm n toasty from all the exercise!! Refrigerator is calling next...
Wait a second- that lead photo is a sink! I was for a moment really freaked out that your sink was that filthy. Thankfully, it was only your oven :)
Truth be told I am dying to get a Kitchenaid stand mixer but at the same time I want to knead my breads on my own. I find there is nothing as relaxing and reward as making bread, even when the bread doesn't come out exactly the way I want it to.
Love, love, love this post! So funny as I have also had a chance to put a little "elbow grease" into a few home projects this past week...and I feel a great sense of satisfaction from it. Nothing quite gives you the same sense of satisfaction as cleaning and organizing! It also got me to move a bit more (as I'm usually chained to my desk)...so there is the added benefit of exercise! That is one of my New Years resolutions...to "move" more.
Elbow grease has always been the best 'product' since the beginning of time.
Love this post, SK!
While I love the sentiment, I'm still gonna use the self cleaning feature on my oven. :)
Love the post, agree with the principle--I'm always taking crap from people who accuse me of "doing things the hard way"--BUT, compromise creeps in. My bread machine is whirring as I type, because my steel & plastic shoulder faints at the thought of kneading bread anymore. Sometimes you just have to suck it up.
I have to agree with samtresler on the whole mixing of vinegar and baking soda. The paste that you are making is really just a water and baking soda paste. Which you might want to do the next time and not add the vinegar. Baking soda is wonderful for soften and tenderizing protein which is why it's great for scrubbing pots and pans as well as clean ovens. I approach oven cleaning in two stages. First, degrease with a good soap like Dawn. Once the soap has been wiped off with a hot wet sponge, make the baking soda paste with water and smear it on. Leave it for a few hours then use that elbow grease to get all the scrub off.
Greatest Kitchn post ever. I'm lucky that I grew up cleaning horse stalls. There is nothing like getting up early, cleaning out a stall, hauling hay and grain then seeing a newly brushed, fed horse reap the rewards of your hard work. So gratifying.
Kudos for avoiding the toxins too. I tend to splatter cleaning fluids everywhere and it's better knowing it is not harsh chemicals I'm getting all over the floor where our pets walk.
Love this post. My cleaning is usually quick and not very deep, simply because of time. I'm amazed every time I do a deep scrub how cathartic it is. I also love the quiet contemplativeness of labor-intensive activities like baking bread or making soup from scratch. The effort is peaceful instead of frantic.
I'm not a big fan of elbow grease, mainly because I'm dealing with fibromyalgia, but I'm a big fan of sticking with a job until it's done right.
Yes! Elbow grease. I recently watched BBC's "Victorian Kitchen" (an oldie, on YouTube) and the sheer amount of physical labor that went into everyday food (albeit for wealthy people) is astonishing. Ditto "Tudor Feast," with my favorite food historian Ruth Goodman, who enlightened me to the fact that in 16th century England, men did the high-status cooking and women did all the physical labor in the kitchens of the nobility. Who knew?
All I know is, when I feel the burn from whipping cream or using my Danish dough whisk instead of an electric mixer to make things, or when I knead bread, or scrub my pots with the gentle scrubbers and a little Bon Ami instead of the more abrasive (but destructive) steel wool, I feel accomplished.
Plus, not using the electric mixer saves on dishes, which technically saves energy (I have no automatic dishwasher) in the future? I like to tell myself that, anyway...
oh sara.... love this post. and will carry this awareness, of what i choose to do by hand, into my year. thank you!
I definitely need to apply some elbow grease to our whole house! I guess that's what Spring Cleaning is for =)
Anyone hankerng to use some elbow grease is welcome to come on a my house!! Plenty to do, I promise.
Whenever I am upset, trying to figure out a problem, etc., I always turn to cleaning as a way to work my way through the issue. When I found out my stepfather died, I came home a furiously cleaned as a way of mourning. I do that same thing with many gardening chores; I weed when I am trying to work through a problem.
bah, HUMBUG


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The last few days have been a bevy of rumors, and then some not rumors being poured all over us. Breathe with me will you? Breathe in, breathe out, Philip Seymour Hoffman– his name will now become our mantra, our ojai breath if you will? Okay, so most people probably know Philip Seymour Hoffman… WAIT! If you don't know why I am talking about Philip Seymour Hoffman at all, here's the deal, he is the first person that Lionsgate has indicated that they have offered a role to. Good? Okay, back to where I was! Hoffman is most likely best known by most for his Oscar-winning performance in the 2005 drama Capote, where he played the title role of Truman Capote, the innovative, eccentric author who penned the acclaimed creative non-fiction novel In Cold Blood, and is most famous for writing the short novel Breakfast At Tiffany's, which was adapted into the film of the same name, that starred Audrey Hepburn. Hoffman won probably 8 + awards for the role alone including the Oscar, as well as a BAFTA, and a Critics Choice Award. It was a pretty awesome performance if I do say so myself, and you'd be hard pressed to find anyone who has seen the film who won't agree.
Hoffman's had a long career though, and it's been made up of just the stuff I was rambling on about in my last article. Meaning, he's exactly the kind of actor I've been personally hoping Catching Fire will be populated with: Critically acclaimed actors, who are mostly known for supporting roles who also split their time with film, TV, and theatre. Yep, and Hoffman just ended a Broadway run as Willy Loman in Death of a Salesman, opposite the new Spider-Man himself, Andrew Garfield, and both of them were nominated for Tony Awards for their performances– not too shabby, eh? I've been a fan of this guys for a long long time, he's kind of scene stealer actually. The first time I ever saw him was in the 1992 film Scent of a Woman, where he played this total asshole rich kid. Yeah, I know, doesn't sound so great, but I assure you, he was a scene stealer, and when I think of that film while, yes– I think of Al Pacino's work in it (won an Oscar), I also think of Hoffman just…making me hate him, but completely remember him. That's a character actor right there! He may play ass-hats from time to time, but you still appreciate the performances, and praise him for them, repeatedly.
Now, we shouldn't get ahead of our selves here, even though Hoffman is the first name to be released in any official capacity having to do with this film, he's only been offered the role, he hasn't actually been cast. I know we all want to start making graphics featuring him in garish suits, and equally garish looking wigs on his head, but I'd just like to warn you all not to do that just yet. The man simply has to say yes, and after that– well, I wholly expect to see an obscene amount of fan-art featuring him.
If the release of Philip Seymour Hoffman's name is any indication, as Frank Sinatra sang so long ago, the best it yet to come…
Them There Eyes
Posted on June 14, 2012, in Actors, Film, Media and tagged Casting, Catching Fire Film, Philip Seymour Hoffman, Plutarch Heavensbee. Bookmark the permalink. 17 Comments.
I really hope he accepts, as he looks perfect to me, and he is an awesome actor as well. Please, don't reject the role…
This keeps changing my name… I'm Abel Toy (Rolpege)
I looked at Catching Fire to see the cast list and he is on it :) fantastic news!
These were my exact thoughts when I found out that PSH had been offered the role! It has definitely calmed my fears about other casting since he's SUCH a great pick for Plutarch. I hope he accepts the part!
Yes, this is exactly the caliber of actor I was hoping for but didn't dare to think we'd get. I really hope he takes it.
Completely agree!!!
Hoffman is a superb professional who has played such an incredible range of parts that you can easily say that not only has he never been type-cast, but he HAS no type. I think his portrayal of Capote probably comes closest to the way he might play Plutarch, minus some of the most flamboyant mannerisms — but with an actor this creative, who knows.
Oh my beating heart!! I actually have goosebumps! He would be perfect. He has this ability to make you fall in love in with him or pray for his death.
The first time I heard his name linked with THG I knew this had to happen. Each day I'm checking to see if he accepts the offer because I would probably squeel in excitement. I love the man as an actor! I've loved what I've seen him in and yet, for some reason, when I think of him, I can't help but chuckle at the fact that he's the reason why I know what the word "sharting" means (I led a sheltered life)… I hate that movie except for him (Not Ben's best and I can't stand Jennifer Aniston).


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Emory Celebrities
2013 Greek Awards Recipients!
April 27, 2013 - 8:36pm
The 2013 Greek Awards took place in Cox Ballroom on Thursday, April 25th. Each chapter nominated members for awards including Best New Member, President, and the Greek Man and Woman of the year. Her Campus Emory would like to honor the winners: Best new members: Tom Ianelli and Janelle Elysee Greek Man and Woman of the Year: Victor Rudo and Catherine Muse President: Dan Bobier and Blair Hunt READ MORE
Feminists in Action President Lindsay Falkenberg '15
April 20, 2013 - 12:00am
I need feminism because…you finish the sentence. Meet Lindsay Falkenberg,'15, president of Feminisists in Action (FIA), the group on campus who sponsored the 'I need feminism because' campaign, as well as others. A Women's Gender and Sexuality Studies major from OH, Lindsay has aimed to make sure Emory is aware of issues regarding gender inequality. So get to know this week's celebrity! Her Campus Emory (HCE): What is Feminists in Action? READ MORE
The PosterFuse Founders
April 13, 2013 - 10:15pm
Emory juniors Stephanie Chan, Michael Simon, and Denver Rayburn were driving back from lunch during move-in week in August when they began discussing how they had so many photos from their summer vacations, but could not think of a fun way to display them in their apartments. Thus, the three students, who are passionate about entrepreneurship and technology, launched their own start-up, PosterFuse. READ MORE
DJ Courtney, Courtney Rivkind '13
April 5, 2013 - 10:46am
If you were at Sigma Chi this past Saturday for the Monster Energy Outbreak College Tour with CLMD, then you for sure witnessed, DJ Courtney. Meet Courtney Rivkin '13, the winner of the Campus DJ competition, which featured 5 DJ's from Emory, GA Tech, and Georgia State on March 26th at Scoreboards. This senior from Miami, FL now has the chance to compete at the National Finale competition in LA for the best student DJ. Her genres of music include House, Electro, Hip-Hop, and Indie. I know I enjoyed DJ Courtney's set on Saturday, so get to know this campus celebrity outside of the DJ scene. Her Campus Emory (HCE): When did you start DJ'ing? Courtney Rivkind (CR): I started DJ'ing almost 6 years ago. ...
Chipper Jones- 2013 Class Day Speaker
March 30, 2013 - 1:21pm
Baseball fans are all excited that Emory's Class Day (Thursday, May 9th) speaker will be former Atlanta Braves third baseman, Chipper Jones. Class Day includes the presentation of class gifts and awards, and a special address from the keynote speaker. After 19 years on the Braves (the only team he has ever played for professionally), Jones retired in 2012 at age 40. His athletic accomplishments include having the most RBIs of any third baseman and being known as one of the best switch-hitters of all time. The Braves will retire his jersey, number 10 this June and will induct him into the Braves' Hall of Fame. Chipper also started the Chipper Jones Family Foundation, through which he has donated to organizations such as the Boys and Girls Club and Little...
Leah Regenbaum '14 President of ASAP
March 21, 2013 - 12:00am
Since Emory has seen a recent increase in reported rapes on campus, many have wondered does this mean more rapes are occurring? Is campus safe? Meet junior Leah Regenbaum, '14, president of the Alliance for Sexual Assault Prevention (ASAP), a group whose mission is to educate the community on sexual violence. Leah is here to discuss her role in ASAP and the impact it has had on Emory's campus. April is Sexual Assault Awareness Month so be on the lookout for ASAP's events on campus! Her Campus Emory (HCE): How did you become involved in ASAP? READ MORE
Men and Women's Basketball Teams—They're Kind Of A Big Deal!
March 7, 2013 - 12:00am
Men and women's teams are UAA co-champions and champions (respectively) and both teams are also contenders for NCAA Division III titles! Men's Team UAA (University Athletic Association) co-champion title: The 72-54 victory over the University of Rochester tied Emory with Rochester and Wash U as UAA co-champions (all three teams have 10-4 records in the UAA league) Big news: The men's team advanced to the NCAA Division III tournament for the first time since 1990. READ MORE
Black Student Alliance President, Jovonna Jones '15
February 28, 2013 - 12:00am
If you've been following the local and national news coverage on President Wagner's controversial comment, you'll probably recognize this campus celeb! She was mentioned in the New York Times and was featured on the HuffPost live with Marc Lamont Hill. Despite all of this, she still has time to run Emory's Black Student Alliance. Catch up with this week's celebrity and my girl Jojo! Name: Jovonna Jones (Jojo) Year: 2015 baybeeee Major: Philosophy Fun facts: I love to sing...and make smoothies…sometimes at the same time. Her Campus Emory (HCE): How did you become involved in BSA? READ MORE
Rita Dove--Emory 2013 Commencement Speaker
February 21, 2013 - 11:34am
Drum role please…the 2013 commencement speaker has finally been selected! And it's Rita Dove! …Wait, who? We're willing to bet that most of you have never heard of poet and author, Rita Dove…but, since she will be delivering a speech (or reciting poetry?!) at graduation this year, it is time to get ourselves familiarized! Quick Facts READ MORE
2012 and 2013 ISC Presidents, Camille Sheppard and Lauren Browning
February 16, 2013 - 11:00am
On bid day 2013, Camille Sheppard passed over the responsibilities of president of Emory's Intersorority Council to Lauren Browning. HCE interviewed both girls in order to get a behind-the-scenes look at ISC. Camille Sheppard/2012 Camille, a senior from Jacksonville, Florida studying history and sociology, is a member of Alpha Delta Pi and has participated in ISC since her sophomore year. She served as her sorority's pan-hellenic representative and enjoyed becoming more involved on campus. We asked Camille to specifically discuss the recruitment process. She says she was very happy with the way things went this year, and congratulated Vice President of Recruitment, Jordan Krant, for her efforts in keeping things running smoothly....
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Flood Recovery, Innovation and Response IVWIT Press 2014; US$ 258.00
Flooding is a global phenomenon that claims numerous lives worldwide each year. Set up to promote research into this area of study, this book contains the proceedings of the 4th International Conference on Flood Recovery, Innovation and Response.This book covers topics related to flooding and its impacts on communities, property and people. more...
Heat TransferWIT Press 2014; US$ 472.00
Heat Transfer XIII: Simulation and Experiments in Heat and Mass Transfer contains the proceedings of the thirteenth conference in the well established series on Simulation and Experiments in Heat Transfer and its applications.Topics covered include: Heat transfer in energy producing devices; Heat transfer enhancements; Heat exchangers. more...
Mobile and Rapidly Assembled Structures IVWIT Press 2014; US$ 288.00
This multi-disciplinary proceedings volume contains papers presented at the fourth International Conference on Mobile, Adaptable and Rapidly Assembled Structures. Topics covered include: Rapidly erected bridges and transportable bridges; Deployable systems and structural mechanisms; Rapidly assembled kit-of-parts systems; Protective structures. more...
High Performance and Optimum Design of Structures and Materials VIIWIT Press 2014; US$ 606.00
This proceedings volume is the first from a new edition of the High Performance Design of Structures and Materials and the Optimum Design of Structures conferences, which follows the success of a number of meetings that originated in 1989. This book will be of interest to those in any engineering field including civil engineering and architecture. more...
Air Pollution XXIIWIT Press 2014; US$ 362.00
The proceedings of the 22nd International Conference on Modelling, Monitoring and Management of Air Pollution, builds upon the prestigious outcomes of the 21 preceding meetings beginning in 1993.Topics covered include: Air pollution modelling; Air pollution mitigation; Air pollution management; Aerosols and particles; Emission studies. more...
Advances in Fluid MechanicsWIT Press 2014; US$ 406.00
Containing the proceedings of the tenth International Conference on Advances in Fluid Mechanics, it follows the success of all previous conferences in the series, the first of which took place in 1996.Topics covered include: Computational methods; Hydrodynamics; Fluid structure interaction; Multiphase flow; Environmental fluid mechanics; Fluidics. more...
Modelling in Medicine and Biology VIIIWIT Press 2009; US$ 266.00
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The New ForestWIT Press 2008; US$ 44.00
This book offers a personal view of the New Forest which stems from the author's many years of residence and research activities within the Forest. This has provided him with a deep appreciation of its unique rural charm and rich history.In writing this book the author wishes to share with readers his own enjoyment of this special part of England.... more...
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For Immediate Release:
January 05, 2012
Media Available
Jenny Slafkosky (415) 528-4367
POSTPONED: Outdoor Screening at the Wave Organ - March 13, 2012
Tentatively rescheduled for Fall 2012.
Free Outdoor Screening: Blackie, Wonder Horse Swims Golden Gate
At the Exploratorium's Wave Organ (weather permitting)
Tuesday, March 13, 2012 - at high tide and dusk – approx. 7 p.m.
As the Exploratorium gears up to relocate to its new home in 2013, the public is invited to a free outdoor screening of "Blackie, Wonder Horse Swims Golden Gate" (1938) and revisit the Exploratorium's Wave Organ, an iconic and popular art installation along the water's edge.
"Blackie, Wonder Horse Swims Golden Gate" is a documentary about the much beloved local horse that made history by swimming across the San Francisco Bay from the Marin County to Crissy Field. This 7-minute short and other films that celebrate the Wave Organ, Golden Gate Bridge, and the surrounding landscape of the Marina will also be shown, said Liz Keim, director of the museum's Cinema Arts program.
The Wave Organ, a wave activated acoustic sculpture, was created in 1986 by Exploratorium artist Peter Richards with stonemason George Gonzalez. Air flows through its more than 20 pipes capturing the sounds of the ocean's tides. It is located at the end Yacht Road off of Marina Boulevard near Crissy Field next to the San Francisco Yacht Harbor. Richards also will be available for questions.
Good walking shoes, warm clothes, blankets, and a flashlight are strongly suggested. Bring a picnic and settle in for one of those truly unique San Francisco events. Seating is limited, late-comers may be turned away.
If you plan on attending, please call the Exploratorium's main office phone line on the day of the event, to verify that it is still on. The event may be cancelled due to inclement weather, or by the Golden Gate National Park Service's discretion: (415) 563-7337.
Hours of Operation & New Evening Hours
Tuesday-Sunday 10am-5pm; every Thursday evening adults only (ages 18 and up) 6pm-10pm.
$29 for adults, with lower rates for SF Bay Area residents, youth, seniors, students, teachers and the disabled. Tickets available at the door and advance tickets available online at www.exploratorium.edu/visit/tickets.
Getting Here
The Exploratorium is easily accessible by public transit. Convenient parking is available nearby. For more information, visit www.exploratorium.edu/visit/location-directions.
About the Exploratorium
The Exploratorium is the global leader in informal learning, igniting curiosity and inspiring creativity in people of all ages. The world-renowned science museum creates original, interactive exhibits, on display at more than 1,000 science centers, museums and public spaces around the world. Dedicated to education reform in and out of the classroom, the Exploratorium is a premier professional development center for educators and a creator of award-winning educational resources. Since 1969, the Exploratorium has influenced generations of entrepreneurs, artists, scientists, teachers, students, children, museum professionals and everyday doers, reaching nearly 180 million people annually from around the globe. On April 17, 2013, the Exploratorium opened at Pier 15 in the heart of San Francisco's Embarcadero, where it will celebrate a new era of experiences that encourage critical thinking and awaken wonder for generations to come. For more information, visit www.exploratorium.edu/visit.
Pier 15
San Francisco
California 94111
(415) 528-4444 telephone
Contact Us:
Jenny Slafkosky (415) 528-4367
Pier 15, San Francisco, CA 94111
(415) 528-4444


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I have a confession to make. I love the new Yahoo! Inquisitor app for the iPhone. I like it better than - gasp - searching Google. But do people from other nationalities, geographic locations and languages feel the same way? They're about to find out.
Yahoo! is releasing its Inquisitor iPhone app to 11 more countries. They are:
- Canada
- France
- Germany
- Italy
- Netherlands
- Spain
- Sweden
- Switzerland
- Australia
- New Zealand
The Inquisitor app is set to Yahoo!'s U.S. index by default, but users can choose another country in the options menu.
Yahoo! acquired the assets of Inquisitor last Spring. Inquisitor began as a search suggestion plug-in for Safari, a web browser developed by Apple who produces the iPhone. Since the acquisition, Inquisitor has been extended to become a plug-in for Firefox and Internet Explorer as well as now the aforementioned app for the iPhone.
The Original Search Marketing Event is Back!
SES Denver (Oct 16) offers an intense day of learning all the critical aspects of search engine optimization (SEO) and paid search advertising (PPC). The mission of SES remains the same as it did from the start - to help you master being found on search engines. Register today!


text: Table 12_1_8-6 2008 National Healthcare Quality and Disparities ReportsThe National Healthcare Quality Report (NHQR) is a comprehensive national overview of quality of health care in the United States. It is organized around four dimensions of quality of care: effectiveness, patient safety, timeliness, and patient centeredness. Table 12_1_8.6Children who had a doctor's office or clinic visit in the last 6 months whose health providers showed respect for what they or their parents had to say, Medicaid, by State, 2007StatePercentSECalifornia62.90.6Colorado72.72.2Connecticut82.51.8Kansas68.32.0Maryland78.50.8Massachusetts78.72.2Michigan73.40.8Missouri72.31.6New Mexico78.81.3Ohio76.30.9Oklahoma71.82.4Pennsylvania72.71.7Tennessee76.11.4Utah76.51.6West Virginia72.72.1Key: SE: standard error.Source: Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, National CAHPS Benchmarking Database. Current as of September 2009 Internet Citation: Table 12_1_8-6: 2008 National Healthcare Quality and Disparities Reports. September 2009. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/research/findings/nhqrdr/nhqrdr08/12_patientcenteredness/T12_1_8-6.html


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TOP 6: Interesting Facts About Neil ArmstrongUS astronaut Neil Armstrong, who took a giant leap for mankind when he became the first person to walk on the moon, has died at the age of 82.
By Reuters, IndiaTimes | August 26, 2012, 7:22 am IST
2 Not a happy man
Neil Alden Armstrong was 38 years old at the time and even though he had fulfilled one of mankind's age-old quests that placed him at the pinnacle of human achievement, he did not revel in his accomplishment. He even seemed frustrated by the acclaim it brought.
"I guess we all like to be recognized not for one piece of fireworks but for the ledger of our daily work," Armstrong said in an interview on CBS's "60 Minutes" program in 2005.
He once was asked how he felt knowing his footprints would likely stay on the moon's surface for thousands of years. "I kind of hope that somebody goes up there one of these days and cleans them up," he said.


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The hotel is small and cosy. Located within walking distance of the square, it is considered to be centrally located. The hotel room offers free wifi. The toilet provides basic amenities. The hotel food is kind of salty and you might get better food at the square.
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Priceline and Odigeo so you can book your Hotel Estrella del Mar reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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The #1 source for fashion inspiration from real people around the world.
HYPE the looks you like to make them hot —or post your own! learn more or sign up now!
This outfit is very much influenced by some of the 'dark romance' looks we have been seeing on the catwalks, I looked for ages for a long lace skirt that I could wear with my Jeffery Cambell black spike platforms and came across this brilliant skirt on the New Look sale for only £8! I have paired it with a New Look top, vintage cardigan, Primark bracelet, Gap belt and Warehouse necklace.
here are some of my favourite runway looks,,,
You can view more pictures and the rest of my blog post here,,,,
by Karen B. · Jun 1, 2013
by Karen B. · May 13, 2013
by Karen B. · Apr 28, 2013
by Karen B. · Apr 5, 2013
by Karen B. · Mar 6, 2013
by Karen B. · Dec 6, 2012
by Karen B. · Dec 5, 2012
by Karen B. · Dec 4, 2012
Blogger at www.fashionisaparty.com from The Netherlands
blogger from Berlin
girl from Poland
girl from petersburg
Fashion blogger from Madrid


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Home > Post > Post 3 > Post 3 News Release > 2010 News Releases > News Release
News Release
Trooper Jonathan Biven
Public Affairs Officer
Kentucky State Police
Post 3, Bowling Green
(270) 782-2010
Click here to e-mail Trooper Jonathan Biven
Post 3 Thanksgiving Holiday Stats
Date of News Release: 12/01/2010
(Bowling Green, Ky.) -- During the Thanksgiving Holiday period, which began Wednesday, November 24 and ended Sunday, November 28, the Kentucky State Police Bowling Green Post issued 547 citations. Seven of which were for DUI. Troopers wrote 265 citations for speeding, 63 citations for seatbelt violations and 7 child restraint violations.
Troopers investigated 37 accidents and inspected 104 vehicles. Seventy-six motorists were assisted during the Holiday period. Troopers and detectives answered 159 complaints, opened six criminal cases and made 12 criminal arrests.


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Kim Kardashian sat down with Jay Leno last night for an interview and showed off her post-baby body in a white lace dress over a black bra and panties. Kim talked about how she lost weight and her surprise proposal on her birthday. Kim Kardashian talked about her sexy swimsuit selfie, telling Jay, "I was …
Copyright – Weld AM FM Gossip 2013. If you see this content on any other website, it has been stolen. Please report.
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Product Recall: We are voluntarily recalling fewer than 8,000 cases of regular Kraft American Singles Pasteurized Prepared Cheese Productlimited to 4 SKUs on two "Best When Used By" dates of February 20, 2015 and February 21, 2015. Click Here.
HEAT oven to 350°F.
PREPARE brownie batter, then cake batter in separate bowls as directed on packages. Spoon brownie mix into 24 paper-lined muffin pan cups; cover with cake batter.
BAKE 21 to 24 min. or until toothpicks inserted in centers comes out clean. Cool cupcakes in pans 10 min.; remove from pans to wire racks. Cool completely.
SPREAD with frosting.


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Farm-fresh B&B Breakfast
read moreread less
Delivered to the kitchen table in our rustic two-floor suite in the converted barn that houses the Glendeven Inn wine bar: eggs with mushrooms and other goodies. just-baked scone, fresh milk, coffee, OJ, and fruit. It helped make a one-night stay feel like a weekend. The view took in the llama pasture, an old water tower, the rugged Mendocino coast, and the ocean.


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Hello all,
We had a lovely holiday to Seton Sands Holiday park near Edinburgh for a week in July. We had a great time.
Our holiday story is in my blog if you'd like to read about it. (pages 1 & 2)
Kerry xThis post was edited by Scottishmummy at September 8, 2012 6:45:18 AM EST
I had an experience at Seton Sands Holiday park with my family and I agree with you this is a very good place for holidays. You can really enjoy your holiday at there. Such a great place.alexander65 at December 5, 2012 2:46:52 AM EST


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|Excellent - 102 reviews
get ready to expand your worldview.. welcome to the Hampton Inn Huntington/Barboursville. To see the world through a different lens, come to the Hampton Inn® Huntington/Barboursville hotel. You'll find artists, performers, students and historians who can expand your mind. Drop by the Huntington Museum of Art for an amazing collection of 19th and 20th century...
Overall Rating - Excellent - 102 reviews
Location, friendly staff, and breakfast
There was garbage underneathe the bed. It was obvious the carpets are not vacuumedCute place
Excellent 10.0
The room was extremely clean and comfortable. The staff was very friendly and the rates were erg reasonable. I loved my stay here and would definitely recommend it to anyone.
|OK - 17 reviews
Overall Rating - OK - 17 reviews
|Excellent - 51 reviews
get to know the beauty of West Virginia.. welcome to the Hampton Inn Winfield/Teays Valley Here at the Hampton Inn® hotel in Winfield/Teays Valley, we're proud to be nestled in this beautiful area of West Virginia. Stay with us, and you'll find yourself within walking distance of a number of restaurants and just minutes from some of the top destinations in t...
Overall Rating - Excellent - 51 reviews
Excellent 10.0
The front desk associates were very friendly & helpful. This is the first stop everyone makes, so the first impression smiles do make a difference. Thanks for making my week stay very enjoyable.
Excellent 10.0
Room was well furnished and clean. Housekeeping was excellent and punctual. Very little noise with the normal day-to-day activities of the hotel. My stay was very pleasant and I would highly recommend this particular hotel.
|Good - 404 reviews
Conveniently located off of I-64 near Huntington Mall, Marshall University, and St. Mary's Hospital, the Red Roof Inn Huntington is 100 percent Smoke-Free, newly renovated and offers Flat Screen TVs in all rooms. This Red Roof is just 6 miles from Pullman Square, Cabell Huntington Hospital, and Huntington Civic Center, and less than a 20 minute drive to Ble...
Overall Rating - Good - 404 reviews
We stayed here based on your reviews and TripAdvisor reviews. There was no hair dryer, the heating/air conditioning system was too complicated to mess with as we arrived late at night and were tired. It was also extremely noisy. We would not stay at a Red Roof Inn again.
Good 8.0
BUT Room 120 has bad king bed - springs busted on one side
|Excellent - 1 reviews
The Best Western Huntington Mall Inn is conveniently located off I-64, within walking distance to seven restaurants and the Huntington Mall is only minutes away. Guests in town for an event at Marshall University, whether it's for graduation or move in weekend, feel right at home when staying at our Huntington hotel. Students, their families, and visiting f...
Overall Rating - Excellent - 1 reviews
Excellent 9.3
Price, convenient location, close to mall, next door to Outback Steak House. Helpful staff.
Smell of smoke in non-smoking rooms. Pillows were small, but they gave us extras. Outdated "business center" which was one computer 10+ years old with a non-wifi printer that was not mac compatible. Internet was slow and buggy. Never hit more than 4mbps down.
|Good - 112 reviews
Overall Rating - Good - 112 reviews
|Excellent - 1 reviews
Barboursville Hotel is Conveniently Located Between Huntington and Charleston Welcome to the new Holiday Inn Hotel & Suites Barboursville . Our hotel is located right off I-64, just 10 minutes from Huntington and a half-hour from Charleston. Families can enjoy visiting a variety of popular attractions near our hotel. Barboursville, West Virginia offers a cha...
Overall Rating - Excellent - 1 reviews
Excellent 9.3
The staff was wonderful. We arrived late. There was an exceptional person working the bar in the restaurant. She was engaging and made us feel welcome in her space.
|Good - 20 reviews
Huntington Hotel's Location is near Marshall University Home to the Thundering Herd, the town of Huntington sits along the scenic Ohio River near the West Virginia, Ohio and Kentucky border. At the all-suite Holiday Inn® Hotel & Suites Huntington - Civic Arena, the hotel's guests enjoy a convenient downtown location next door to Big Sandy Superstore Arena. S...
Overall Rating - Good - 20 reviews
Mediocre 4.0
Made my reservations well in advance. When I and my family arrived, we were given our room keys and went up to the room. I placed the key in, opened the door and found the beds un-made towels on the floor and the tv on. L ucky for us we did not encountr an embarrassing situation. We had just driven over nine hours to get there. When we went to the front desk about it, there was no apology. It was just try this one and we got another room key. On our second nite, those room keys did not work. Talk about lack of professional courtesy and lack of security. I did not trust that someone could have used another key to access our room. Thank God that did not happen.
Excellent 10.0
Very nice people at front desk, offered free parking in garage behind hotel, good location right downtown, would stay here again for sure
|Good - 130 reviews
Now 100 Percent Smoke-Free includes Newly Renovated Rooms with Flat Screen TVs. A great location near Tri-State Greyhound Park! Waves-of-Fun Water Park, Blenko Glass, Charleston Civic Center, Kanawha Dragway, and Toyota Motor Manufacturing are all within a 15-30 minute drive. Close to plenty of local shopping
Overall Rating - Good - 130 reviews
Poor 1.0
Reservation booked wrong, no room available, no effort made to help us & card was billed anyway. No effort to correct that.Discourteous front desk staff, no effort to help. Displayed an attitude of 'sorry bout your luck, get out.' I went to another hotel, which was also booked, but they made the effort to locate a room actually closer to our event & helped with directions!
close to expressway and clean
considering the price I would have expected light breakfast be offered.
|Good - 41 reviews
Welcome to Super 8 Huntington West Virginia. Easy access off I-64 with nearby attractions - Benjys Harley Davidson Museum, Camden Amusement Park, Marshall University and Blenko Glass Company. Huntingtons newest property features Indoor Pool, Fitness Center, High Speed Wireless Internet, Super Start Breakfast and Whirlpool and Efficiency Suites
Overall Rating - Good - 41 reviews
|OK - 309 reviews
The Days Inn Huntington is conveniently located at I-64 Exit 15, about 3 miles from Marshall University. We offer free Daybreak continental breakfast 6am-9am, free wireless high speed internet access, Nancys Lounge onsite, guest laundry, and a seasonal outdoor pool. Each room is equipped with a refrigerator, iron and board, coffee maker, hair dryer, and ca...
Overall Rating - OK - 309 reviews
Poor 2.0
My party had a total of three rooms at the Days Inn, and two of them reeked to high heavens. I think it was probably due to some sort of water problem - the carpet around the fridge was soaked and remained so throughout the three-day stay. I would have checked out shortly after checking in had I not prepaid. The staff was either grumpy (one guy yelled at me to watch my kids, who were no more than 20 yards in front of me) or unhelpful. Oh, and two rooms had orange signs warning of contamination from recent drug labs that were removed. We won't be going back here again.
Mediocre 4.0
I called and requested a first floor room as soon as I made the reservation and was told I was all set - I am unable to climb steps without a great deal of pain. When we checked in, I was told that this was not noted on my reservation and they could not possibly accommodate me without a handicap sticker. I don't have one as I am only impaired when it comes to stairs. No attempt was made to accommodate me. Also, the rooms could have been cleaner - there was a message written on the bathroom wall that was no even cleaned up.
|Excellent - 4 reviews
Set in downtown Huntington - home of Marshall University and the Thundering Herd - the friendly and modern Hampton Inn Huntington University Area hotel boasts a convenient location just off I-64 and is close to the university's campus, popular scenic areas and parks and the local restaurants, shops and businesses of downtown Huntington Feel at home in your c...
Overall Rating - Excellent - 4 reviews
Excellent 10.0
Room was extremely nice an fitness room was actually usable.Much better than I'd expected.
Excellent 10.0
It was very clean and NEWMy child is going to attend college in the area and I would definately stay there again.
|Good - 220 reviews
Refresh at this Ramada Limited Huntington hotel conveniently located off Interstate 64 near Cabell Huntington Hospital, concerts and events at Big Sandy Arena, Huntington Tri-State Airport, Marshall University, Blenko Glass Company, and many local restaurants. Relax at this hotel with deluxe continental breakfast, indoor pool, sun deck, hot tub, fitness cent...
Overall Rating - Good - 220 reviews
Excellent 10.0
The entire staff was very friendly I asked for directions to a certain location and they were able to tell me. Breakfast was good and the location of the hotel was just five minutes from where I wanted to go I would stay here again. Very Good Hotel.
NoNot much more I can say, easy access to and from the interstate. Has a pool a hot tub and an exercise room it is also close to different restaurants it met all my needs.
The area around the hotel. 2 fastfood restaurants within walking distance, plus a gas station/convenience store.
No refridgerator in the room. Hallways smelled like smoke. There were smoking rooms located in the hotel.Everything was clean. Everything appeared new. The a/c was super cold. I had Dierctv in the room with free HBO. Free breakfast was what anyone would expect for free, but Bob Evans was right accross the street if you need a big meal in te morning. Also, my dog enjoyed her quiet time when left alone in the room.
|Excellent - 80 reviews
Conveniently located off Interstate 64, this Ramada Limited Catlettsburg/Ashland hotel is near Huntington Tri-State Airport, downtown Ashland, Camden Amusement Park, caverns and waterfalls at Carter Caves State Park, hiking at Grayson Lake State Park, prehistoric artifacts at the Northeastern Kentucky Museum, shopping, golfing, and many local restaurants. Af...
Overall Rating - Excellent - 80 reviews
Excellent 10.0
Very clean for an old hotel
Walls extremely thin/could hear noise from other rooms
Excellent 9.0
Very good experience. Clean rooms, quiet at night, friendly staff.
|Excellent - 35 reviews
Overall Rating - Excellent - 35 reviews
Excellent 10.0
everyone was super nice! rooms were clean, comfy and quiet!! Thanks for a great stay!! Breakfast should stay open past 9am!
Excellent 10.0
Good value for the money. Would stay again. Clean and new furnishings.


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A Ticket to Ride from AdComm to PDUFA
REZA is a member of The Motley Fool Blog Network -- entries represent the personal opinion of the blogger and are not formally edited.
After receiving a positive AdComm vote, both Arena Pharma (NASDAQ: ARNA) and Vivus (NASDAQ: VVUS) are taking the train from AdComm to PDUFA.
About a week before arrival Vivus was notified by the FDA that PDUFA would be delayed for three months, which would give the FDA time to sort out the REMS program. Some believe this delay to be positive, arguing no news on a CRL is good news. Others are not as optimistic, arguing there is still a solid chance for the FDA to ask Vivus to perform more pre-approval work and therefore issue a CRL for which FDA needed more time.
My guess is that Vivus will get approved but with heavy restrictions, and Arena will be the first to market. Orexigen Therapeutics' (NASDAQ: OREX) obesity medication train is far behind the other two and no arrival time has been specified. The obesity market is so large that there is plenty of room for different tools. Lorcaserin is in a unique position that, due to its excellent safety, it can be used for a wide range of patients.
As for international travel, at least in Europe, Arena's in the lead, and I anticipate by 4Q2012 it will have its European Ticket To Ride.
Arena's train left the AdComm station to the cheers of a 19-4 vote in favor. (The 19 votes includes one abstention, which was not allowed; the AdComm administrator asked the FDA if a new vote should be taken and the answer was no, as an 18-4-1 was a clear indication of the panel's sentiments. However, the abstaining voter admitted to not knowing abstentions aren't allowed and that the vote would have been a yes).
Either way, it was a strong endorsement. Given the positive tone of the FDA briefing documents and the urgent nature of the obesity epidemic, it's fair to expect Arena a yes vote at PDUFA, although the timing has been a subject of debate since the AdComm. Reporters like Adam Feuerstein, who published plenty of unfounded negativity about Arena prior to AdComm, are now singing their gloomy song of delays, but that call is as non-credible as their negativity prior to AdComm.
Just after admitting they made the wrong call, Jim Cramer's crew is making yet another wrong call: the need for REMS (see Dr. Lopez's discussion below). A commentator on a recent negative piece put it nicely:
"AF has been wrong all along... I don't see him improving his record on Arena, or any stock for that matter. His opinion isn't even up for consideration."
Others, including respectable doctors, maintain that due to the epidemic and urgent need for a solution, FDA is doing everything it can to approve Lorcaserin as soon as possible, and at the latest by June 27. The bottom line is we just don't know. If I had to guess I'd say Arena will receive the good news by June 27. The reasoning is that any post-marketing study will not be complicated to define and I do not believe REMS will be required.
The expert views of three physicians indicate why Arena's ride to approval may be a smooth one.
Safety Concerns about Vivus' Qnexa
Dr. Syed Sayeed, medical director of Missouri Delta Medical Center, is very interested in seeing Lorcaserin approved. He's eagerly awaiting Lorcaserin because he faces the obesity epidemic every day. Dr. Syed however, has serious concerns about Qnexa's safety. He wrote:
"Many obese patients have anxiety problems and when they're started on Phentermine it exacerbates the anxiety symptoms. Phentermine could cause severe aggression and agitation in patient with underlying bipolar disorder. Phentermine is used by physicians for short term because of addiction potential and if used for long periods it could cause dependency. If Qnexa is used for longer periods and by millions of people it could be a disaster for our nation -- it will make millions of people addicted to Phentermine and government need to open rehab for Phentermine dependency. In Europe you will find Phentermine addiction clinics for those who were abusing Phentermine. There is a higher chance of Qnexa being abused and no physician would write Qnexa and prefer to write Phentermine alone for short periods if needed".
In contrast, Dr. Syed finds Lorcaserin safe and he's keen on using it on most of his obese patients as soon as it's available.
No REMS for Lorcaserin
Vivus has to do a REMS because Qnexa has safety issues, which Lorcaserin does not have. Many experts have commented on whether REMS will be required, including Dr. Daniel P. Lope, M.D., F.A.C.O.G., an obstetrician and gynecologic surgeon in Los Angeles who is interested in Lorcaserin because endocrinology is a major field in the specialty of gynecology, and obesity is a significant problem in both obstetrics and gynecology. He made the following comments, which I reprint with permission:
"The following discussion is the basis for my opinion as to why a REMS will not be required for valvulopathy.
First of all everyone talks about valvulopathy but does everyone understand the clinical significance of this entity? If you don't I will first discuss it and then discuss the FDA findings regarding the risk.
The FDA case definition of valvulopathy: requires documented mild or greater aortic regurgitation OR moderate or greater mitral regurgitation.
REMS will not be needed. The FDA conditions for a REMS (from the guidance in the FDA website): REMS will be required if it is necessary to ensure that the benefits of the drug outweigh the risks of the drug – that is, the seriousness of any known or potential adverse effects that may be related to the drug. There are others but these are the relevant ones for our discussion. Remember, the word is SERIOUSNESS. Here are the reasons REMS will not be required:
1. Clinical significance: Aortic regurgitation (AR): long term prognosis, especially those who are asymptomatic, has a favorable outlook and this has been well documented. It evolves in a very slow and insidious manner and has very low morbidity during a LONG asymptomatic course; this can remain for decades and usually does not progress to treatment. Only those that develop severe AR can result in left ventricular dysfunction, and eventually heart failure. This was rare with dexfenfluramine which by the way, AR was the primary lesion, not mitral regurgitation (MR). With lorcaserin it is the opposite – most common lesion was MR.
2. Mitral regurgitation (MR): isolated mild to moderate MR is without symptoms – very little overload of the heart – heart function remains normal. Even with severe MR, most remain without symptoms until there is left heart failure, pulmonary hypertension, or atrial fibrillation. There were no cases of this with lorcaserin.
3. In fact, because of the benign nature of these lesions the guidelines for followup of patients who had been on dexfenfluramine are the following:
- Physical exam with auscultation of the heart. In the absence of heart murmurs or other findings, exam is repeated in 6 months – the absence of heart findings by stethoscope predicted the absence of echocardiographic valvular regurgitation in 93% of patients, while the presence of murmur had only a positive predictive value of 19%;
- Echocardiography is only indicated in the presence of murmurs, symptoms, or difficult exam by stethoscope due to body habitus;
- If a lesion is found, depending on severity, followup is between 6-12 months because of the slow progression to more serious lesions.
So those who are suggesting that echocardiograms will be required you can see this is nonsense. Any patient who presents to doctors office should have an exam, including the heart by stethoscope. You do not need to have a REMS requiring echos because all you need what is normal practice in an office. Of course any patients on anorectic medications will especially need a heart exam in the office by the MD with a simple stethoscope.
CONCLUSION: ECHOCARDIOGRAPHY is not necessary to evaluate these patients who will be lorcaserin.
Every author who wrote an article suggesting the need of a REMS based on valvulopathy [e.g. Adam Freuerstein] has no clue what they are talking about. If they had spent time understanding the clinical significance and the analysis of the data in the FDA BD they would not come to that conclusion.
The following is all based on the data in the FDA BD:
- Plasma levels of lorcaserin at the clinical dose of 10 mg bid is substantially below the EC50 for activation of 5HT2A and 5HT2B based on functional receptor activation assays whereas the plasma levels of lorcaserin remain within the selective range for activation of 5HT2c. In plain English, plasma levels of lorcaserin are not high enough to activate 2a and 2b receptors but are high enough to active 2c receptors. That is, activation of 2a and 2b at therapeutic levels is unlikely.
- Functional profiling studies showed that lorcaserin had the same potency for activating 2B receptors as did the compounds known NOT to cause valvulopathy – demonstrating a low risk of lorcaserin to behave as a valvulopathogen.
- The FDA commented that the more appropriate data in determining risk for VHD was these functional profiling studies along with the receptor activation assays and the echocardiography data from the clinical trials.
- FDA's position was that ruling out a relative risk of 1.5 for FDA-defined VHD was an ARBITRARY but reasonable endpoint. They acknowledged the difficulty in obtaining a noninferiority margin smaller than 1.5 because it would require a very large study.
- As noted above fenfluramine VHD was driven by increases in AR whereas lorcaserin was more MR than AR. I will spare you the statistical gymnastics and get to the conclusions:
Pooled phase 3 trials:
Only one patient in the phase 3 trials developed severe MR – and this was in the placebo group; no patients developed AR.
In the BLOSSOM and BLOOM DM trials patients were allowed to enroll with preexisting FDA-defined VHD. Lorcaserin did not develop worsening of their VHD over the 52 weeks as compared to placebo, which had an increase in worsening.
Now when they looked at patients at week 52 (LOCF) you get the following:
- 2.0% of patients on lorcaserin and 1.7% placebo developed moderate or severe regurgitation at week 52
- BLOOM – DM at week 52(LOCF) 1.9% of patients on lorcaserin and 1.0% placebo developed moderate regurgitation. NO PATIENTS IN BLOOM DM DEVELOPED SEVERE REGURGITATION AT ANY VALVE.
- NO patient in any phase 3 trial treated with lorcaserin required heart valve surgery or replacement. FURTHERMORE, NO patient treated with lorcaserin reported symptoms from valvular regurgitation.
- POOLED nondiabetic phase 3 trials: 0.3% on lorcaserin bid and 0.1% on lorcaserin qd and four on placebo had cardiac murmur
- BLOOM DM two (0.8%) on lorcaserin 10 bid had murmur – no increases in scores in regurgitation scores for any valve in those two patients.
CONCLUSION: The functional profiling, receptor activation assays, and the echocardiographic studies demonstrate the safety of lorcaserin and also demonstrate THE LACK OF ANY CLINICAL SIGNAL.
Any consideration for a REMS with regard to valvulopathy is purely theoretical based on a theoretical cutoff point PERIOD."
With REMS not required most people I talk to believe the FDA will meet the June 27 PDUFA date and not delay the approval of Lorcaserin.
EKG Not Necessary; Valvulopathy Non-Issue?
Dr. Murthy Andavolu, a specialist in hematology and oncology in California, was appalled by some of the Lorcaserin AdComm panel members' argument about need for EKG.
"The most insane thing I heard in the Arena AdComm was about doing EKGs for patients on Lorcaserin. What is the screening value of EKGs for valvular heart disease? I find it appalling that some physicians talked about it in the AdCom. I am a physician - a non-cardiologist physician - but I can guarantee you that EKGs have no value in patients taking this drug (or any drug) to look for valvulopathy. If they recommend an echo I can understand though not agree with it, but an EKG, for Christ's sake!!"
A cardiologist published (and this) in reaction to some of the discussion in the AdComm, claiming some of the AdComm members did not have an in-depth understanding of the subject of EKGs and valvolupathy. He further contends vallulopathy to be a "NON issue".
Another Doctor's Plea to the FDA
In a letter to the FDA on May 20 May, Dr. Steven Vig, a practicing internist in Tuscon who treats obese patients, encouraged the FDA to approve Lorcaserin as soon as possible (reprinted with permission):
"As a practicing internist in Tucson, Ariz., I would encourage the FDA to grant approval for lorcaserin (Lorqess) on or before the PDUFA date of 6 27 2012. Lorcaserin will be indicated for weight loss in patients with BMI over 30, or for patients with BMI over 27 who have co-morbidities. Arena Pharmaceuticals did a wonderful job of answering all questions in the Complete Response Letter, and the FDA Advisory Committee members voted 18 to 4 in favor of lorcaserin (with one member abstaining) on 5 10 2012.
Any concerns about breast cancer in rats were answered by the pathology review of the previous rat slides, and by additional studies on prolactin done in the last two years by Arena Pharmaceuticals. Obesity is associated with higher rates of cancer, and there is reason to believe that patients who lose weight due to lorcaserin may actually have lower rates of cancer. Average weight loss on patients who completed lorcaserin for a year was 18 pounds, and the top 25% of weight losers lost an average of 35 pounds.
Receptor studies have shown a high degree of specificity of lorcaserin for the 5HT2C receptor (the weight loss receptor), and a very low activity at the 5HT2B receptor (the valvulopathy receptor). Heart rate and blood pressure levels are not increased by lorcaserin. Pooled analysis of the Bloom, Blossom, and Bloom DM studies have not indicated an issue with cardiac valve disease due to lorcaserin. In fact, the two year data in the Bloom study showed a 2.7% chance of valvulopathy on PLACEBO, and a 2.6% chance of valvulopathy on lorcaserin. Lorcaserin at exposures of up to 50 times the human dose for a year did not induce changes in cardiac valves or the pulmonary vasculature in monkeys. I do not believe that a requirement for echocardiogram monitoring is necessary in patients who take lorcaserin.
The Bloom DM (diabetes mellitis) one year study produced a 27 point drop in the fasting glucose level on lorcaserin, along with a 0.9 point drop in the hemoglobin A1C level (compared to a 0.4 point drop on placebo). These improvements are comparable to many of the diabetes pills that we currently use!
I see overweight and diabetic patients every day. 2/3 of Americans are overweight, and 1/3 of Americans are obese. Physicians often refer to the BIG FOUR DIAGNOSES in a patient, which includes obesity, diabetes, hypertension, and hyperlipidemia. Patients who are obese have higher rates of cancer, back pain, knee pain, hip pain, fatty liver, venous insufficiency (swelling of the legs), cardiovascular disease, and sleep apnea compared to patients with normal weight. The cost to America in terms of morbidity, mortality, and work disability is enormous, and getting worse. Other than diet and exercise, current medications for weight loss are limited, and have side effects. Lorcaserin has a very benign safety profile, and I am convinced that lorcaserin will be the first medicine that most doctors will reach for when prescribing a treatment for weight loss in a patient.
Lorcaserin is a 5HT2c receptor agonist, and causes lower dopamine levels in the brain. Studies from Duke University Medical Center in 2011 showed that rats given lorcaserin used less nicotine. Studies of 5HT2c agonists in rats also showed a decreased tendency to use cocaine. Decreases in dopamine lower the tendency for excessive gambling, and for sexual addictions. 25 years of research on the 5HT2c serotonin receptor has been documented in the 2010 medical textbook "5HT2C RECEPTORS IN THE PATHOPHYSIOLOGY OF CNS DISEASE" by Giuseppe Di Giovanni.
Physicians are in desperate need of weapons for the War on Obesity. Please don't send us back into battle unarmed. Please approve this novel agent lorcaserin (Lorqess) for weight loss as soon as possible!"
Lorcaserin's Low Potential for Abuse
The question of Schedule 4 labeling was on the minds of some investors. In a new article, Dr. Vig argues why Lorcaserin is not a controlled substance, and therefore has low potential for abuse.
I see a green light for the Arena Train to arrive at the Approval station and deliver a much needed gift to millions of obese patients and doctors who are eager to see their patients benefit from this marvelous novel agent.
I own shares in Arena because I believe Lorcaserin will be approved and it will be able to capture a large share of the enormous obesity treatment market. I like Lorcaserin's very good safety profile and its good efficacy. I also like the fact that so many doctors are highly interested in this molecule and really want it as part of their toolkit. The opinions expressed in this article are not investment or medical advice. Please do your own research. For more information about the author please visit www.rezamusic.com. The Motley Fool has no positions in the stocks mentioned above. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy. If you have questions about this post or the Fool's blog network, click here for information.


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Have made this dish twice to rave reviews from the family.
Grilled Steak-and-Ratatouille Salad with Basil-Garlic Vinaigrette
Photo: Jennifer Davick
Yield: Makes 4 servings
More From Southern Living
Recipe Time
Hands On:
40 Minutes
Total: 1 Hour, 30 Minutes
- 2 (8-oz.) beef tenderloin fillets
- 1 teaspoon freshly cracked pepper
- 1/2 teaspoon kosher salt
- 2 small yellow squash, cut in half lengthwise
- 2 small zucchini, cut in half lengthwise
- 2 small eggplants, cut in half lengthwise
- Basil-Garlic Vinaigrette
- 3 plum tomatoes, cut in half lengthwise
- 1 (8-oz.) package romaine lettuce heart leaves
- 1. Preheat grill to 350° to 400° (medium-high) heat. Sprinkle fillets with pepper and salt, and let stand 15 minutes. Toss squash, zucchini, and eggplant with 3 Tbsp. Basil-Garlic Vinaigrette.
- 2. Grill steaks, covered with grill lid, 5 to 6 minutes on each side or to desired degree of doneness. Remove steaks, and cover with aluminum foil. Let stand 10 minutes.
- 3. Meanwhile, grill vegetable mixture, covered with grill lid, 5 to 6 minutes on each side or until tender. Add tomato halves during last 6 minutes of grilling time, and grill 3 minutes on each side or until softened and warm.
- 4. Coarsely chop grilled vegetables, and toss together. Cut steak into thin slices. Fan romaine leaves onto a serving platter. Top with grilled vegetables and steak slices; drizzle with desired amount of vinaigrette.
- Note: We tested with Organic Girl Romaine Heart Leaves.
My Notes
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Grilled Steak-and-Ratatouille Salad with Basil-Garlic Vinaigrette Recipe at a Glance
- COURSE: Main Dishes, Salads
- CONVENIENCE: Entertaining
- CUISINE: French
- MAIN INGREDIENT: Beef, Vegetables
- COOKING METHOD: Grill
- OCCASION: Summer
- PUBLICATION: Southern Living
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Ayo! This is my blog, I ♥ Science, Music, Paul McCartney and his band The Beatles, all of these stuffs are found here. Well I could be random sometimes. So, enjoy and FOLLOW!
How Strange Twinned Rainbows Form
A twinned primary rainbow produced through computer simulation. The rainbow is split because of the interaction of light with two types of water drops: some smaller, spherical ones, and some larger water drops that become nonspherical. The different shapes cause light to leave the water drops in two different directions, which causes the rainbow to split into two arcs, a study presented in August 2012 found. CREDIT: UCSD / Jacobs School of Engineering.
Double rainbows had their fifteen minutes of fame on the Internet. Now get ready for their even more mysterious cousins: twinned rainbows. New research has suggested an explanation for these exotic shows of color.
Rainbows are known to form when sunlight interacts with tiny water drops in the atmosphere. As sunlight gets both reflected and refracted within the drops, it gets separated into its basic color components. Still, all the secrets of the more complex behavior of rainbows have long remained a puzzle.
The most common rainbow has a single arc. The less common double rainbow, which consists of two separate, concentric arcs, has inspired Internet memes. Triple and quadruple rainbows have even been spotted. Even rarer, however, is the twinned rainbow, where two arcs split from a single base rainbow.


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Do you know about s.uconn.edu ? UConn students, faculty, and staff can go to the site, login via NetID, and take advantage of a more trustworthy URL shortener than bit.ly, etc. We asked UITS for this service and it works like a charm. Great for social media sharing needs. Includes usage monitoring statistical tools. Tailor your bulky addresses down to size!
Library webcam
We have a webcam overlooking the new Oak Hall, just east of the Homer Babbidge Library. Take a peek at:
Library vendor services mobile apps
Our eResources Management Librarian has put together a Mobile Research guide that lists the mobile tools available from the research databases we subscribe to. We've made a place for it on the mobile site, under "Find Books and Articles." See:
Let us know if you have any favorites in this category, or if we've missed one that you use.
PC availability web app upgraded
Update 8/27/2012: Library PCs have been virtualized and are available everywhere from every device. (One consequence is that we are no longer able to pinpoint available workstations.) Please visit vPC.uconn.edu
Original posting:
We recently recoded the web app that lets you check for open workstations in library computer labs. It's now using JQuery Mobile, for those interested. It loads faster than before, so if you were frustrated by it in the past, try it now:
Calendar as info display tool
Here's one of those little things: Humans have been interacting with information for some time, but these days we forget sometimes how useful old models can be. We used to display our operating hours in just a complicated series of charts with exceptions, but in response to a request from our public services staff, we've got our hours info up in a new-fashioned monthly calendar format, which is easier to process visually but a tad harder to compose programatically . Let us know how we can make it better.
Topic-specific RSS newsfeed
We're starting to implement newsfeeds for topics of interest to our researchers. See an example at:
Could be a convenient way to stay current on what's happening in your field, with info from a variety of sources. Would you like one for your subject?
If I come to the library, would a public computer be available?
Announcing a new feature on the mobile site that allows you to check for an available workstation in one of the public computer labs. See: http://lib.uconn.edu/m/#_pcavail
HBL for now, with Regional Campuses, plus Pharmacy and Music coming soon!
Mobile Device site from UConn Libraries
We are pleased to announce a new beta site optimized for mobile devices. Visit www.lib.uconn.edu/m to try it on your iPhone, Android, or other smartphone. And improvements and handy additions are already in the works, so stay tuned.
UConn Libraries' Newest Search Tool Test: EBSCO Discovery Service beta
Here's our first Try This: UConn Libraries' trial of the EBSCO Discovery Service (EDS) beta–a single search box that retrieves hits consolidated from indexes of books in our libraries, article databases, locally digitized collections, and more.
Click here to give it a whirl.
News flash: As of 11/11/2010, this search tool now features the records from our Institutional Repository, digitalcommons.uconn.edu !


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Reader Comments (Page 1 of 1)
CursedSeishi said...
@Clbll, read what I said. A voidwalker tank made the encounter trivial, yes they rectified that with the patch, but does it matter anymore? No. Cause now we'll have all this shiny new Ulduar gear to compensate. And while they removed the glory of the naxx raider achieve and mount, they still let us get the Sarth 10 and 25man drake. Is that fair? No.
@Super, thanks, I agree that the main reason it seems harder is that its new, give the number crunchers and achievement freaks some time, and we'll see plenty of "Ulduar hard-mode for dummies" pop up.
And moondah, +50% health and +25% damage a hard mode does not make, neither does adding an eight minute time limit. The only "Hard Mode" encounter I'd say is deserving of it is The Iron Council. Its unique, at least in terms of the current expansion.
A hard mode should be hard, not because of simple buffs, but because the encounter changes radically.
Alganon for instance, you have to kill the four watchers in their hardmodes to get to him. Instead of a quest, killing him should reward you with a hard mode for Yogg-Saron. Not just lower sanity, or more damage. But the titans themselves intervening. They come down and start attacking Ulduar, adding in new, random elements into the attack. Parts of the ceiling come crashing down atop players, but can be used to break those who have fallen under Yogg's sway by making it fall on him. Beams of energy rip across the ground, damaging anyone foolish enough to stay in its path, even after its done. As time goes on, the titans get closer and closer, more and more attacks are unleashed, until they break into the area the players in and wipe the slate clean. An instant wipe, including Yogg. Sure people would complain that they only get one shot, but thats the only way it would truelly be hard.


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2012-11-14 / Events & Calendar
Help to protect and restore the Massapequa Preserve
Friends of the Massapequa Preserve invites the community to its fall public meeting to be held Thurs., Nov. 15, 7:30 p.m. at the Massapequa Public Library, 40 Harbor Ln., Massapequa Park.
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1001 9th Avenue has a Walk Score of 28 out of 100. This location is a Car-Dependent neighborhood so most errands require a car.
This location is in Albany. Nearby parks include Hilsman Park, Madison Park and Tift Park.
Nearby schools include Northside Elementary School, Life Christian Academy Of Palmyra and Albany High School.
The closest grocery stores are Harvey's Supermarket, Jlo African Foods Store and Super 8 Albany.
The closest coffee shop is Starbucks. Nearby restaurants include Villa Gargano, Krystal and House of You.
1001 9th Avenue is near Albany State University.