text:
Research Topics
Genomes and Genes
Gene Symbol: HMGA2
Description: high mobility group AT-hook 2
Alias: BABL, HMGI-C, HMGIC, LIPO, STQTL9, High-mobility group protein HMGI-C, high mobility group AT-hook protein 2, high mobility group protein HMGI-C, high-mobility group (nonhistone chromosomal) protein isoform I-C
Species: human
Top Publications
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Scientific Experts
Detail Information
Publications194 found, 100 shown here
- Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationChristine Mayr
Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 315:1576-9. 2007..chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA...
- The HMGA proteins: a myriad of functions (Review)Isabelle Cleynen
Laboratory of Molecular Oncology, Department of Human Genetics, University of Leuven, Herestraat 49 bus 602, Leuven, Belgium
Int J Oncol 32:289-305. 2008..members: HMGA1a, HMGA1b and HMGA1c, which result from translation of alternative spliced forms of one gene and HMGA2, which is encoded for by another gene...
- HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinomaAlexandra C Hristov
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mod Pathol 22:43-9. 2009..The high mobility group A2 (HMGA2) protein is an architectural transcription factor that has recently been implicated in the development and ..
- A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formationMasashi Narita
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Cell 126:503-14. 2006..activities are canceled by coexpression of the HDM2 and CDK4 oncogenes, which are often coamplified with HMGA2 in human cancers...
- HMGA2 participates in transformation in human lung cancerFrancescopaolo Di Cello
Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cancer Res 6:743-50. 2008..studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined...
- HMGA2 gene is a promising target for ovarian cancer silencing therapyAnastasia Malek
Department of Pharmacology and Toxicology, Philipps University School of Medicine, Marburg, Germany
Int J Cancer 123:348-56. 2008..In our previous work, we showed upregulation of HMGA2 gene expression as a result of Ras-induced rat ovarian surface epithelial cell transformation...
- cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypesG Manfioletti
Universita di Trieste, Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Italy
Nucleic Acids Res 19:6793-7. 1991..Analysis of mRNA levels demonstrate that the HMGI-C gene is not expressed in a variety of mouse tissues but is expressed in Lewis lung carcinoma cells...
- Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transitionSylvie Thuault
Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden, and Institut National de la Sante et de la Recherche Medicale, Hopital E Herriot, Lyon Cedex, France
J Cell Biol 174:175-83. 2006..Transcriptomic analysis revealed that the high mobility group A2 (HMGA2) gene is induced by the Smad pathway during EMT...
- HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaBIsabelle Cleynen
Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B 3000 Leuven, Belgium
Mol Cancer Res 5:363-72. 2007..We recently identified the Imp2 gene as a target gene of the architectural transcription factor HMGA2 (high mobility group A2) and its tumor-specific truncated form HMGA2Tr...
- Common variants in the GDF5-UQCC region are associated with variation in human heightSerena Sanna
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Genet 40:198-203. 2008..reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population...
- Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2Michela A Tessari
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole Centre of Excellence in Biocristallography, University of Trieste, Via L Giorgieri 1, 34127 Trieste, Italy
Mol Cell Biol 23:9104-16. 2003The HMGA2 protein belongs to the HMGA family of architectural transcription factors, which play an important role in chromatin organization...
- Identification of novel HMGA2 fusion sequences in lipoma: evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3' UTR is not critical for HMGA2 transcriptional upregulationXiaoke Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Genes Chromosomes Cancer 48:673-8. 2009..Rearrangement of HMGA2 in chromosome band 12q15 has been found in approximately 60-70% of ordinary lipomas with cytogenetic abnormalities...
- High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinomaCarla Hebert
Diagnostic Sciences and Pathology, University of Maryland Baltimore, Baltimore, Maryland 21201 1586, USA
Mol Cancer 6:5. 2007b>HMGA2 expression has been shown to be associated with enhanced selective chemosensitivity towards the topoisomerase (topo) II inhibitor, doxorubicin, in cancer cells...
- Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavityJun Miyazawa
Department of Oral and Maxillofacial Surgery, Nippon Dental University, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
Cancer Res 64:2024-9. 2004..b>HMGA2 is an architectural transcriptional factor that is expressed in the undifferentiated mesenchyme and initiates ..
- The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6Riccardo Sgarra
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Italy
J Biol Chem 281:3764-72. 2006..The in vivo association of HMGA and PRMT6 place this yet functionally uncharacterized methyltransferase in the well established functional context of the chromatin structure organization...
- HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomasIvana De Martino
Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Italy
Cancer Res 69:1844-50. 2009..We have recently reported that transgenic mice carrying the Hmga1 or Hmga2 genes under transcriptional control of the cytomegalovirus promoter develop pituitary adenomas secreting prolactin ..
- The tumor suppressor microRNA let-7 represses the HMGA2 oncogeneYong Sun Lee
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
Genes Dev 21:1025-30. 2007b>HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign mesenchymal tumors and lung cancers...
- HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapyHeike Summer
Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
Nucleic Acids Res 37:4371-84. 2009..Intriguingly, HMGA2 is also found in rare tumor-inducing cells which are resistant to chemotherapy...
- Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2Koen R M O Crombez
Department of Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, Herestraat 49 bus 602, B 3000 Leuven, Belgium
Mol Cancer Res 3:63-70. 2005The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin...
- Genome-wide association study reveals multiple loci associated with primary tooth development during infancyDemetris Pillas
Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
PLoS Genet 6:e1000856. 2010..loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer...
- HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent ampliconAntoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
Int J Cancer 122:2233-41. 2008..In addition, using quantitative RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 (12q14...
- Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA familyKazuo Motoyama
Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
Clin Cancer Res 14:2334-40. 2008The high mobility group A2 (HMGA2) nonhistone chromosomal protein can modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during embryogenesis and in various benign and malignant tumors...
- High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cellsOu Li
Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
Genesis 44:523-9. 2006..The non-histone chromatin-associated factor HMGA2 has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipocytic ..
- HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasiasGennaro Chiappetta
Istituto Nazionale dei Tumori, Fondazione Pascale, Via Mariano Semmola, 80131 Naples, Italy
Eur J Cancer 44:1015-21. 2008We have analysed the expression of the HMGA2 gene in a panel of normal and neoplastic thyroid tissues by immunohistochemistry and quantitative RT-PCR...
- Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15M Nilsson
Department of Clinical Genetics, University Hospital, Lund, Sweden
Cytogenet Genome Res 112:60-6. 2006..The HMGA2 gene is often rearranged, but little is known about the molecular consequences at other breakpoints...
- High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activityLars Borrmann
Center for Human Genetics, University of Bremen, Leobenerstr ZHG, D 28359 Bremen, Germany
Nucleic Acids Res 31:6841-51. 2003High mobility group A2 (HMGA2) chromosomal non-histone protein and its derivatives play an important role in development and progression of benign and malignant tumors, obesity and arteriosclerosis, although the underlying mechanisms of ..
- A common variant of HMGA2 is associated with adult and childhood height in the general populationMichael N Weedon
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
Nat Genet 39:1245-50. 2007..Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P = 4 x 10(-8))...
- Genome-wide association analysis identifies 20 loci that influence adult heightMichael N Weedon
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
Nat Genet 40:575-83. 2008..genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes...
- Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromasAnna Dahlén
Department of Clinical Genetics, University Hospital, Lund, Sweden
Mod Pathol 16:1132-40. 2003..The HMGA2 (HMGI-C) locus in 12q15 is frequently rearranged in other benign mesenchymal tumors, and this study aimed at ..
- HMGA2 overexpression in non-small cell lung cancerBritta Meyer
Centre for Human Genetics, University of Bremen, Bremen, Germany
Mol Carcinog 46:503-11. 2007..Overexpression of the high mobility group protein HMGA2 has been observed in a variety of malignant tumors and often correlates with poor prognosis...
- HMGA2 is expressed in an allele-specific manner in human lipomasHena R Ashar
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
Cancer Genet Cytogenet 143:160-8. 2003The architectural transcription factor HMGA2 is almost exclusively expressed in undifferentiated mesenchymal cells...
- An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissueN Abe
First Department of Surgery, Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka, Tokyo 181 8611, Japan
Br J Cancer 89:2104-9. 2003The altered form of the high-mobility group A2 (HMGA2) gene is somehow related to the generation of human benign and malignant tumours of mesenchymal origin...
- Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumoursE F Schoenmakers
Laboratory for Molecular Oncology, University of Leuven, Belgium
Nat Genet 10:436-44. 1995..These results suggest a link between a member of the HMG gene family and benign solid tumour development...
- Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15)Inga von Ahsen
Center of Human Genetics, University of Bremen, Germany
Cancer Genet Cytogenet 163:68-70. 2005..t(3;12)(q27 approximately 28; q14 approximately 15) in lipomas and pulmonary chondroid hamartomas (PCHs) makes the HMGA2-LPP fusion gene the most frequent fusion gene in human tumors...
- HMGIC expression in human adult and fetal tissues and in uterine leiomyomataG J Gattas
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Chromosomes Cancer 25:316-22. 1999The high-mobility-group (HMG) protein gene, HMGIC, is localized to chromosome 12, band q15, a region often rearranged in benign mesenchymal tumors, including uterine leiomyomata...
- Identification of ten loci associated with height highlights new biological pathways in human growthGuillaume Lettre
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Nat Genet 40:584-91. 2008..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait...
- Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domainsH R Ashar
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
Cell 82:57-65. 1995..These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation...
- HMGI/Y proteins: flexible regulators of transcription and chromatin structureR Reeves
Department of Biochemistry Biophysics, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
Biochim Biophys Acta 1519:13-29. 2001....
- Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2Sun Mi Park
The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
Cell Cycle 6:2585-90. 2007..expression of a number of genes such as c-myc and RAS as well as the embryonic gene high mobility group, A2 (HMGA2). We now demonstrate that HMGA2 is more efficiently targeted by let-7 than RAS...
- Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomasH R Ashar
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
Genomics 31:207-14. 1996b>HMGIC, a member of the HMGI family of high mobility group proteins, is disrupted in 3/3 lipomas characterized by 12q14-q15 rearrangements...
- DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cellsOu Li
Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
FEBS Lett 581:3533-7. 2007..We showed recently that among the major HMG proteins, HMGA2 is highly expressed in two human embryonic stem (hES) cell lines...
- The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and functionGiacomo Cattaruzzi
Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Udine, Italy
Nucleic Acids Res 35:1751-60. 2007..Here, we report the identification and characterization of a nuclear localization signal (NLS) for HMGA2, a member of the HMGA family...
- HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activityMonica Fedele
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
Cancer Cell 9:459-71. 2006b>HMGA2 gene amplification and overexpression in human prolactinomas and the development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role in pituitary tumorigenesis...
- High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activationLee Ming Boo
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033 1049, USA
Cancer Res 65:6622-30. 2005The high mobility group A2 (HMGA2) protein belongs to the architectural transcription factor HMGA family, playing a role in chromosomal organization and transcriptional regulation...
- Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletionJ I da Motta
Department of Pharmacology, , Brazil
Br J Pharmacol 112:111-6. 1994..antagonist (BN 50730), a cyclo-oxygenase inhibitor (indomethacin), a lipoxygenase inhibitor (MK-886), a dual type lipo- and cyclo-oxygenase inhibitor (NDGA), a bradykinin antagonist (Hoe 140) or the combination of cetirizine, MK-886, ..
- HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumorPei Hui
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
Mod Pathol 18:1519-26. 2005..To this end, we explored diagnostic applications of HMGA (HMGA1 and HMGA2) protein immunohistochemistry in comparable groups of synovial sarcoma and malignant peripheral nerve sheath ..
- Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiaeO Schonberger
Department of Molecular Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
Mol Microbiol 5:2663-71. 1991..coli lipoprotein signal sequence attached to the mature sequence of the B subunit of heat-labile enterotoxin (Lipo-EtxB) was expressed in yeast and E. coli. Analyses of cell lysates from Saccharomyces cerevisiae and E...
- Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene functionDeborah S Hunter
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Cancer Res 62:3766-72. 2002..Concomitantly, HMGA2 protein, which was completely absent in normal myometria, was expressed in 16 of 19 Eker leiomyomas...
- HMGA1 and HMGA2 protein expression in mouse spermatogenesisPaolo Chieffi
Dipartimento di Medicina Sperimentale, II Universita di Napoli, Via Costantinopoli 16, 80138 Naples, Italy
Oncogene 21:3644-50. 2002The high-mobility group A (HMGA) nonhistone chromosomal proteins HMGA1 and HMGA2 play a role in determining chromatin structure and in regulating the transcription of several genes...
- Thyroid cell transformation requires the expression of the HMGA1 proteinsMaria Teresa Berlingieri
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita Degli Studi Di Napoli, Via Pansini 5, 80131 Naples, Italy
Oncogene 21:2971-80. 2002Elevated expression of HMGA1 and HMGA2 proteins is correlated with a highly malignant phenotype in several human tumors...
- Fusion of HMGA2 to COG5 in uterine leiomyomaGopalrao V N Velagaleti
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55906, USA
Cancer Genet Cytogenet 202:11-6. 2010..Approximately 10% of these tumors contain rearrangements of the chromatin-remodeling gene HMGA2 at the chromosome band 12q14.3. Herein, we report on a uterine leiomyoma with a novel HMGA2 fusion gene...
- High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cellsA Richter
Centre for Human Genetics, University of Bremen, Bremen, Germany
Eur Cell Mater 21:355-63. 2011In previous research, it was shown that recombinant HMGA2 protein enhances the proliferation of porcine chondrocytes grown in vitro, opening up promising applications of this embryonic architectural transcription factor for tissue ..
- SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasomeXuefei Cao
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA
Mol Cancer Ther 7:923-34. 2008The HMGA2 architectural protein functions in a variety of cellular processes, such as cell growth, transcription regulation, neoplastic transformation, and progression...
- Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic miceH Helen Lin
Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA, USA
Eur J Oral Sci 115:30-9. 2007High mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor...
- Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic dataLaurence Bianchini
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Genes Chromosomes Cancer 50:442-55. 2011The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors (AT) and, second, to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing ..
- Isolation and characterization of the gene coding for murine high-mobility-group protein HMGI-CG Manfioletti
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Italy
Gene 167:249-53. 1995..A highly homologous pseudogene is also present in the mouse genome. Our results on Hmgi-c structure provide basic information to carry out further studies on the regulation of its expression...
- Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangementKatsuaki Sato
Department of Pathology II, Kanazawa Medical University, Ishikawa, Japan
Pathol Int 60:760-4. 2010..This report describes the first case of an odontogenic myxofibroma presenting with HMGA2 protein overexpression and HMGA2 rearrangement in a 40-year-old woman. A 2...
- Genomic structure and expression of the murine Hmgi-c geneX Zhou
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
Nucleic Acids Res 24:4071-7. 1996..Since the human homolog is disrupted in a number of tumors, HMGI-C could play an important role in cell proliferation and differentiation during mammalian development...
- Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 casesNadège Dreux
Department of Pathology, Institut Bergonie, 229 Cours de l Argonne, Bordeaux Cedex, France
Mod Pathol 23:1657-66. 2010The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of ..
- Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblastsM Fedele
Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Naples, Italy
Oncogene 17:413-8. 1998..The unrearranged wild-type HMGI-C cDNA did not exert any transforming activity. These findings indicate that rearranged forms of HMGI-C play a role in cell transformation...
- [Expression of regulatory T cells and related cytokines in mice allogenic corneal transplantation rejection]Xin Wang
Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China
Zhonghua Yan Ke Za Zhi 45:1118-26. 2009..To study the changes of CD4(+)CD25(+) and CD8(+)CD103(+) regulatory T cells and their relevant cytokines in corneal allograft transplantation in mice...
- Uric acid enhances T cell immune responses to hepatitis B surface antigen-pulsed-dendritic cells in miceXiao Jun Ma
Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, Hubei Province, China
World J Gastroenterol 13:1060-6. 2007..To study the induction of T cellular immune responses in BALB/c mice immunized with uric acid and dendritic cells (DCs) pulsed with hepatitis B virus surface antigen (HBsAg)...
- Current data on ATP-containing liposomes and potential prospects to enhance cellular energy status for hepatic applicationsV Korb
AGEPS, APHP, Faculté des Sciences Pharmaceutiques et Biologiques Paris Descartes, Paris, F 75006 France
Crit Rev Ther Drug Carrier Syst 25:305-45. 2008..Second, studies conducted with ATP liposomally entrapped (lipo-ATP) are described, including pharmaco-technical formulation engineering and related models of assessment...
- Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritisHermann Josef Grone
Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Lab Invest 82:5-14. 2002..suggests that factors that contribute to the development of atherosclerosis, ie, oxidatively modified (lipo)proteins, may also participate in glomerular injury...
- Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivityNing Li
Department of Pathology, Yale University School of Medicine, New Haven, CT 06504 8900, USA
Am J Dermatopathol 26:267-72. 2004..CD34 and Factor XIIIa staining is commonly used in separating DF from DFSP, but is not always helpful. HMGA1 and HMGA2 genes, members of the high mobility group protein family genes, encode proteins that act as architectural ..
- Bezafibrate affects lipid, lipo- and apolipoprotein pattern in non-insulin-dependent diabetic patientsG Niort
Istituto di Medicina Interna, University of Torino, Italy
Horm Metab Res 25:372-4. 1993..Bezafibrate use was safe and improved the lipid pattern and the apolipoprotein and lipid distribution in the lipoproteins, producing a less atherogenic pattern in our NID diabetics...
- Specific beta-lactam antibiotics inhibit secretion of lipo-beta-lactamase in yeastA London
Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Mol Microbiol 4:2193-200. 1990The beta-lactam antibiotic cloxacillin can inhibit secretion of prokaryotic lipo-beta-lactamase into the periplasm of yeast...
- The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?Kurt Pfannkuche
Institute for Neurophysiology, University of Cologne, Robert Koch Str 39, 50931, Cologne, Germany
Stem Cell Rev 5:224-30. 2009..For example, HMGA2 is involved in transcriptional activation of certain cell proliferation genes, which likely contributes to its ..
- MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedemaChristian Lohrmann
Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg i Br, Germany
Microvasc Res 77:335-9. 2009To assess for the first time the morphology of the lymphatic system in patients with lipedema and lipo-lymphedema of the lower extremities by MR lymphangiography.
- [Pulmonary complications in patients with AIDS]Shinichi Oka
AIDS Clinical Center, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
Kekkaku 77:37-40. 2002..LDS was first reported as re-distribution of lipid such as central obesity with or without lipo-atrophy from extremities and/or face...
- Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletionTakashi Yamamoto
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
Cell Tissue Res 332:245-56. 2008..of Kupffer cells after their elimination by administration of liposome-entrapped dichloromethylene diphosphonate (lipo-MDP)...
- Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without osteopoikilosisFrancesca Mari
Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
Eur J Hum Genet 17:1141-7. 2009..Among the deleted genes, HMGA2 is of particular interest in relationship to the aberrant somatic growth in our patient, as HMGA2 variants have ..
- [Effects of alprostadil in prevention of portal vein thrombogenesis after splenectomy and devascularization: a clinical observation of 76 patients with portal hypertension]Jian Cang Ma
Department of General Surgery, Second Affiliated Hospital of Xi an Jiaotong University, Xi an 710004, China
Zhonghua Yi Xue Za Zhi 88:524-6. 2008To investigate the effects of alprostadil (Lipo PGE1) in prevention of portal vein thrombogenesis (PVT) after splenectomy for portal hypertension.
- Structural and immunochemical characterization of a Neisseria gonorrhoeae epitope defined by a monoclonal antibody 2C7; the antibody recognizes a conserved epitope on specific lipo-oligosaccharides in spite of the presence of human carbohydrate epitopesR Yamasaki
Department of Biochemistry and Biotechnology, Tottori University, Tottori 680 8553, Japan
J Biol Chem 274:36550-8. 1999b>Lipo-oligosaccharides (LOS) produced by Neisseria gonorrhoeae are important antigenic and immunogenic components of the outer membrane complex...
- The association of lipodystrophy and oxidative stress biomarkers in HIV-infected menHelena S Vassimon
Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Curr HIV Res 8:364-9. 2010..In a cross-sectional study of blood samples from HIV-infected men with lipodystrophy syndrome (HIV+LIPO+ = 10), HIV-infected men without lipodystrophy syndrome (HIV+LIPO- = 22), and healthy subjects (control = 12), the ..
- Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarityEduardo N Taboada
Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
BMC Genomics 8:359. 2007..Although sialylated ganglioside-mimicking lipo-oligosaccharide (LOS) structures are the strongest neuropathogenic determinants in C...
- Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cellsMasaru Murakami
Laboratory of Molecular Biology, Azabu University School of Veterinary Medicine, Sagamihara, Japan
Mol Biol Rep 37:1279-86. 2010..In epithelial cells, TGF-beta-induced high mobility group A2 (HMGA2) gene product is suggested to down-regulate E-cadherin through up-regulation of zinc-finger transcription factors ..
- Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasionJutamas Ngampasutadol
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 180:3426-35. 2008Complement forms a key arm of innate immune defenses against gonococcal infection. Sialylation of gonococcal lipo-oligosaccharide, or expression of porin 1A (Por1A) protein, enables Neisseria gonorrhoeae to bind the alternative pathway ..
- Genetic basis of uterine leiomyoma: involvement of high mobility group protein genesW J Van de Ven
Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven, and Flanders Interuniversity Institute for Biotechnology, Belgium
Eur J Obstet Gynecol Reprod Biol 81:289-93. 1998..12q13-15 or 6p21 has led to the discovery that two members of the high-mobility group (HMG) protein gene family, HMGIC and HMGIY, are frequently rearranged in such tumors...
- Construction and analysis of cells lacking the HMGA gene familyBrett Beitzel
Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Nucleic Acids Res 31:5025-32. 2003..high mobility group A (HMGA) family of non-histone chromosomal proteins is encoded by two related genes, HMGA1 and HMGA2. HMGA proteins are architectural transcription factors that have been found to regulate the transcription of a ..
- A crucial role of a high mobility group protein HMGA2 in cardiogenesisKoshiro Monzen
Department of Cardiovascular Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nat Cell Biol 10:567-74. 2008..This leads to the active transcription of their target genes. Here we show that HMGA2, a member of the HMGA sub-family of HMG proteins, has a critical function in cardiogenesis...
- In nondiabetic, human immunodeficiency virus-infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistanceSteen B Haugaard
Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
Metabolism 54:171-9. 2005..We studied 18 HIV-infected patients with lipodystrophy (LIPO) on antiretroviral therapy and 25 HIV-infected patients without lipodystrophy (controls) of whom 18 were on ..
- HMGA1 and HMGA2 rearrangements in mass-forming endometriosisFabiola Medeiros
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Genes Chromosomes Cancer 49:630-4. 2010..endometriosis, and six endometriomas were investigated by fluorescence in situ hybridization (FISH) for HMGA1 and HMGA2 loci, performed on paraffin-embedded thin tissue sections with custom-designed probes...
- Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center SeriesApostolia Maria Tsimberidou
Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
Leuk Lymphoma 47:1062-8. 2006The present study aimed to investigate single-agent liposomal all-trans retinoic acid (Lipo-ATRA) in untreated acute promyelocytic leukemia (APL). Induction therapy consisted of Lipo-ATRA 90 mg/m2 i.v. every other day...
- [Pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone hydrochloride]Cai Xia Wang
Hebei Pharmaceutical Technology and Engineering Research Center, Shijiazhuang 050051, China
Yao Xue Xue Bao 45:1565-9. 2010..study is to compare the pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone (Mit-lipo) and free mitoxantrone (Mit-free)...
- A dose-response study of epidural liposomal bupivacaine in rabbitsJ M Malinovsky
Laboratoire d Anesthésie et Chirurgie Expérimentale, Universite de Nantes, Nantes, France
J Control Release 60:111-9. 1999..phosphatidylcholine-cholesterol) suspensions contained 20 mg ml-1 of lipid, and different doses of bupivacaine (Lipo 7.5=7.5-; Lipo 3.7=3. 75-; Lipo 2.5=2.5-; Lipo 1.2=1.25-; and Lipo 0.7=0.65-mg of bupivacaine per ml)...
- Mutation of the htrB locus of Haemophilus influenzae nontypable strain 2019 is associated with modifications of lipid A and phosphorylation of the lipo-oligosaccharideN G Lee
Department of Microbiology, University of Iowa, Iowa City 52242, USA
J Biol Chem 270:27151-9. 1995..SDS-polyacrylamide gel electrophoresis analysis revealed that the lipo-oligosaccharide (LOS) isolated from these mutants migrated faster than the wild type LOS and its color changed from ..
- [Contributions and results of lipo-structure in repair and rejuvenation of frontal anatomical unit]A Chichery
Service de Chirurgie Plastique, centre hospitalier Saint Luc et Saint Joseph, 20, Quai Claude Bernard, 69003 Lyon, France
Ann Chir Plast Esthet 54:93-102. 2009..In this work, we want to estimate contribution of lipo-structure in repair and rejuvenation of frontal anatomical unit (FAU)...
- Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosaM Halwani
The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
J Antimicrob Chemother 62:1291-7. 2008The aim of this study was to enhance the antimicrobial efficacy of a liposomal gentamicin formulation with gallium metal (Lipo-Ga-GEN) against clinical isolates of Pseudomonas aeruginosa.
- Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistributionSteen B Haugaard
Clinical Research Unit, Hvidovre University Hospital, DK 2650 Hvidore, Copenhagen, Denmark
Metabolism 56:939-46. 2007..To address this issue, the secretion patterns of SP and IP of 16 HIV-infected men with lipodystrophy (LIPO) and 15 HIV-infected men without lipodystrophy (NONLIPO) were studied during an oral glucose tolerance test (OGTT)...
- Binding the mammalian high mobility group protein AT-hook 2 to AT-rich deoxyoligonucleotides: enthalpy-entropy compensationSuzanne Joynt
Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA
Biophys J 96:4144-52. 2009b>HMGA2 is a DNA minor-groove binding protein...
- Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT)Tengjiao Cui
Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
J Mol Biol 352:629-45. 2005The mammalian high mobility group protein A2 (HMGA2) is a chromosomal architectural transcription factor involved in oncogenesis and cell transformation...
- Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophySteen B Haugaard
Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
Diabetes 54:3474-83. 2005..Skeletal muscle biopsies, obtained from 18 lipodystrophic nondiabetic patients (LIPO) and 18 nondiabetic patients without lipodystrophy (NONLIPO) before and during hyperinsulinemic (40 mU.m(-2)...
- [Intravenous delivery of cationic liposomes conjugation to recombinant adenoviral vectors containing human endostatin gene inhibits ovarian cancer growth in nude mice]Li Wang
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China
Sichuan Da Xue Xue Bao Yi Xue Ban 40:190-4. 2009..To evaluate the anticancer effect of liposome plus Ad-Endostatin complex on human ovarian serous cystocarcinoma...
- Polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein are associated with chronic spontaneous urticaria and urinary leukotriene E4Gabriele Di Lorenzo
Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Palermo, Italy
Eur J Dermatol 21:47-52. 2011..Our working hypothesis is that polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein may be involved in the pathways leading to CSU...
- Nodulation protein NodL of Rhizobium leguminosarum O-acetylates lipo-oligosaccharides, chitin fragments and N-acetylglucosamine in vitroG V Bloemberg
Institute of Molecular Plant Sciences, Leiden University, The Netherlands
Mol Microbiol 11:793-804. 1994Upon induction of their nodulation genes, the root nodule-inducing Rhizobium bacteria produce lipo-oligosaccharide signal molecules. All lipo-oligosaccharides identified from Rhizobium leguminosarum bv...
- NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22Antoine Italiano
Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
Genes Chromosomes Cancer 47:971-7. 2008Lipomas are frequently characterized by rearrangements resulting in the fusion of the HMGA2 gene (12q14.3) with a variety of partners. Chromosome band 9p22 rearrangements occur in about 1% of lipomas...
- Expression of the early nodulin, ENOD40, in soybean roots in response to various lipo-chitin signal moleculesE Minami
Department of Microbiology, University of Tennessee, Knoxville 37996 0845, USA
Plant J 10:23-32. 1996The lipo-chitin (LCO) nodulation signal (nod signal) purified from Bradyrhizobium japonicum induced nodule primordia on soybean (i.e. Glycine soja) roots...
- Hyperproinsulinaemia in normoglycaemic lipodystrophic HIV-infected patientsS B Haugaard
Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, Copenhagen, Denmark
Eur J Clin Invest 36:436-45. 2006..precursors, intact (IP) and 32-33 split proinsulin (SP), which are elevated in states of insulin resistance and predict type 2 diabetes, would be elevated in human immunodeficiency virus (HIV)-infected patients with lipodystrophy (LIPO).
- Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cellsSteen B Haugaard
Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
Eur J Endocrinol 152:103-12. 2005..Aiming to provide a detailed description of the metabolic adverse effects of HIV-lipodystrophy, we investigated several aspects of glucose metabolism, lipid metabolism and beta-cell function in lipodystrophic HIV-infected patients...
Research Grants63
- Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPsNILS WALTER; Fiscal Year: 2007..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
- Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPsNils G Walter; Fiscal Year: 2010..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
- MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSIONDavid Ann; Fiscal Year: 2002..Moreover, the proposed study is of great significance as the dysregulation of this Raf-1 mediated process could lead to cell transformation. ..
- RpoS-mediated virulence regulation in Borrelia burgdorferiJON SCOTT BLEVINS; Fiscal Year: 2010..undergoes significant adaptive changes, which includes altering the expression of several major outer surface (lipo)proteins...
- Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMRJacob Schaefer; Fiscal Year: 2010..to the biomedically relevant characterization of new types of cyclic antimicrobial peptides, lipodecapeptides and lipo-octapeptides...
- Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol HomeostasisKamal D Mehta; Fiscal Year: 2010..Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions through sterol-response element binding protein-1c (SREBP-1c) is limited, as is the role of ..
- Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol HomeostasisKAMAL MEHTA; Fiscal Year: 2009..Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions through sterol-response element binding protein-1c (SREBP-1c) is limited, as is the role of ..
- Genetic Studies of Uterine LeiomyomataCYNTHIA CASSON MORTON; Fiscal Year: 2010..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGA2 and HMGA1, located on chromosomes 12 and 6, respectively, participate in the pathobiology of uterine leiomyomata, ..
- Structure and Function of Treponema pallidum LipoproteinsMICHAEL NORGARD; Fiscal Year: 2009..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
- Structure and Function of Treponema pallidum LipoproteinsMichael V Norgard; Fiscal Year: 2010..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
- Regulation of Signaling Receptor Activity by LRP-1Steven L Gonias; Fiscal Year: 2010..b>Lipo- polysaccharide challenge experiments will be conducted in mice in which LRP-1 is conditionally deleted in ..
- The role of PON-2 and PON3 proteins in atherosclerosisSrinivasa Reddy; Fiscal Year: 2007..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
- The role of PON-2 and PON3 proteins in atherosclerosisSrinivasa Reddy; Fiscal Year: 2009..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
- Polymer-Based Yersinia Pestis Point-of-Case DiagnosticsJean Clarke; Fiscal Year: 2004..amplification of fluorescence transduction events to rapidly identify species-specific genomic, proteomic, and lipo-oligosaccharide (LOS) markers of Y. pestis...
- The role of PON-2 and PON3 proteins in atherosclerosisSrinivasa Reddy; Fiscal Year: 2010..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
- MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATACynthia Morton; Fiscal Year: 2002..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGIC and HMGlY, located on chromosomes 12 and 6, respectively participate in the pathobiology of uterine leiomyomata...
- Saw Palmetto, Cyclooxygenase, and Prostate CancerCHARLES ROSELLI; Fiscal Year: 2006..The lipo-sterolic extract of saw palmetto (SPE) has been shown to be as effective as finasteride in the treatment of urinary ..
- Metabotropic glutamate receptors in the vagal processing of taste informationROBERT HALLOCK; Fiscal Year: 2007..Second, mGluR agonists have recently been shown to decrease lipo-polysaccharide induced anorexia...
- ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMACheryl Walker; Fiscal Year: 2006..abstract_text> ..
- LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLSUlrich Hammerling; Fiscal Year: 1993We have identified a lipo-protein complex with growth-promoting properties in supernates of human lymphoblastoid cell lines and activated normal B cells. The protein moiety is prealbumin which originates from the culture medium...
- The Role of MicroRNAs in Tumor ProgressionMarcus E Peter; Fiscal Year: 2010..The early embryonic gene HMGA2 was found to be a prime target of let-7 and was found to be upregulated in tumor cells from advanced ovarian ..
- Novel Fas/CD95 Signaling MechanismsMarcus E Peter; Fiscal Year: 2010..expression of the microRNA let-7 and we obtained evidence that let-7 drives tumor progression through targeting HMGA2 and IMP-1...
- Validation of HMGI-C as a Drug Target in Colon CancerROLAND CHOUINARD; Fiscal Year: 2002..It is now estimated that in the United States alone, 129,400 new cases of colon cancer were reported, indicating the demand for safe, reliable pharmaceuticals. ..


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Denver Broncos outside linebacker Danny Trevathan is poised to see a significant jump in playing time in the 2013 NFL season. After a standout 4-year career at the University of Kentucky, Trevathan was nabbed by the Broncos in the sixth-round of the 2012 NFL Draft, despite finishing among the SEC's top-tacklers his final two seasons as a Wildcat.
Ironically, he took a similar path that former Wildcat and current Denver starting LB Wesley Woodyard too, only he went from going undrafted in 2007, to now being a starting outside linebacker for a Broncos team that's many expert's pick to win the Super Bowl in 2013.
Trevathan, much like Woodyard, had the knock on him out of college was that he is just too undersized at 6 foot and 240 pounds.
Trevathan, now a second-year player, played all 16 regular-season games and finished second among Denver's rookies with 30 tackles in 2012, just seven behind defensive tackle Derek Wolfe, who played far more significant time than Trevathan. He'll be counted on to do more in 2013, especially for the first six games. During that time, Denver will be without it's All-Pro linebacker, Von Miller, who is facing a six-game suspension from the NFL for violating the league's substance abuse policy.
That means for at least the first six games, Trevathan will have a golden opportunity to show the coaching staff why he deserves to be on the field more.
Tags: Denver Broncos

subset: commoncrawl


text:
Our Summer hours are
Monday ~ Sunday 11:00am to 9:00pm
We serve Premium Farm Fresh, Homemade Ice Cream. We also offer a variety of other Dairy Products such as Specialty Flavored Milk, Butter, and many delicious types of Cheese.
Our Ice Cream is available in Cups, Cones, and our Homemade Waffle Cones and Bowls. We also offer Milkshakes, Floats, Sundaes, Pints, Quarts, Banana Splits, Ice Cream Sandwhiches and Ice Cream Cakes. Personalized Ice Cream Cakes are available with 24 hours notice. Try our new flavors Orange-Pineapple, Cotton Candy, and Peanut Butter Swirl!
We hope that you will stop by and visit us!
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text:
If an all loving, all caring God existed it is quite clear he would have created the planet Earth differently.
For example he would have made the entire planet at a constant temperature of about 75 degrees Fahrenheit (sorry I don't do Centigrade).
He would have made humans so they didn't need to eat, drink so there would be no need to build disgusting sewers to dispose of our waste. He would make us so we would have no need to sleep, wash or go to work. All these things take up so much time when we could be out playing and having fun.
He would make our bodies unbreakable so if we fell from a great height we would just get up, shake ourselves and carry on as though nothing happened like cartoon characters.
These are just some examples. So I pass it on to you. what would you have have done differently if you were God?
Views: 29


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Read more at Bake or Break.
Preheat oven to 350°. Grease or line baking pans.
Whisk together flour, baking powder, and salt. Set aside.
Beat butter, cream cheese, sugar, and brown sugar until fluffy. Add eggs, 1 at a time, mixing well after each addition. Mix in vanilla.
Gradually add flour mixture, mixing until almost combined. Add chocolate chips, stirring until dough is thoroughly mixed.
Drop dough by tablespoonfuls onto prepared pans. Bake 12-15 minutes, or until edges are lightly browned. (These cookies will not brown like classic chocolate chip cookies.)
Cool cookies completely on pan on wire racks.
Makes about 4 dozen cookies.


text:
» Indicates Expanded Online Showroom.
|City, State
|Abanaki Corp., Oil Skimmer Div.
|Chagrin Falls, OH
|Amiberica, Inc.
|Chicago, IL
|Arbortech Corporation
|McHenry, IL
|Carbtrol Corp.
|Bridgeport, CT
|CETCO Oilfield Services Company, Industrial Wastewater Treatment
|Hoffman Estates, IL
|CJI Process Systems
|Santa Fe Springs, CA
|Cleaning Technologies Group, LLC, Ransohoff
|Cincinnati, OH
|DMP Corporation
|Rock Hill, SC
|Duall, a CECO Environmental Company
|Owosso, MI
|FMT Inc.
|Findlay, OH
|Global Filtration Systems, Inc.
|Tamworth, NH
|GOAD Company
|Ellisville, MO
|Graymills Corporation
|Chicago, IL
|Hardwood Line Mfg. Corp.
|Chicago, IL
|Hilliard Corp., The -Hilco Division
|Elmira, NY
|Jackson Oven Supply, Inc.
|Jackson, MI
|Jayto Corp.
|Sussex, WI
|Berlin, CT
|Keller Products, Inc.
|Acton, MA
|Milanco, Inc.
|Gastonia, NC
|Palm International Inc.
|LaVergne, TN
|ProChem Inc.
|Elliston, VA
|Rosedale Products, Inc.
|Ann Arbor, MI
|Separation Dynamics
|Fountain Inn, SC
|SERFILCO, Ltd., Service Filtration Corp.
|Northbrook, IL
|Treatment Products Corp.
|Thorndale, PA
|Wayne Products, Inc.
|Frazer, PA
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text: Video Overview Of The myTouch 4G Slide Camera T-Mobile is certainly looking to hype up the biggest selling point of the myTouch 4G Slide, its camera. With a 68 second video you can take a look at what kind of features you can expect when you get your hands on the 4G Slide later this month. I'll say that the lack of a shutter lag is a feature I'd love to see on more camera phones and digital cameras in general. Take a look at the vid! YouTube Tags: 4g slide, Android, camera, Doubleshot, Mytouch, myTouch 4G Slide


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After a busy weekend, with our daughter's birthday party the day before, I woke up in my own bed as rested as I've ever been before a race and we headed down to the 7:00 am start. I ran off to use the bathroom one last time and then headed to the start. It's fun to race locally because there are a lot of familiar faces and a lot of our friends were racing, but I never did find my husband again before the race started.
On the way back in, I just kept my pace the best I could and then I started doing the math in my head and it occurred to me that I was on pace for 1:45:xx, so I tried to pick it up a bit. Knowing the course helped a ton! When I rounded the corner to the finish line, I saw the clock and knew I need to really kick it in. As I crossed the finish line, the clock said 1:45:01, but my Garmin said 1:44:44.
Thankfully, I did have a few seconds to spare and 1:44:42 was my official time. A PR of about two and a half minutes. I was 5th in my AG and the 17th woman. And I definitely met my goal of running a half marathon under 1:46! I was pretty happy!
It was a great race and a day of PRs! My husband PR'd too, by three minutes! Our good friends ran their first half and did amazing! My brother-in-law came in second in the marathon with a six minute PR just weeks after running an amazing 100 mile race!! And another friend ran a 3:20 marathon qualifying her for Boston.
What a day!


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PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
May 09, 2014
Suitable for use in baths as large as 20 L and compatible with DIN 12876-1 Class I non-flammable liquids, LX Immersion Circulator delivers intuitive temperature control for day-to-day laboratory applications. Digital readout displays actual bath temperature and set point temperature simultaneously. Along with ambient +10° to 98°C temperature range and ±0.07°C temperature stability, features include timer, single-speed pump, heavy-duty mounting clamp, and fully integrated housing.
IMS Company
Chagrin Falls, OH 44023
Mar 05, 2014
Constructed mostly of stainless steel, including 1 hp pump and 14 gallon tank, IMS Hydra Water Cooled Circulator uses glycol, virtually eliminating rust and other long-term issues related to water use. Combination of high-speed digital PID temperature controller with 9 kW heating element allows accuracy in process water at ±1°F variance. Circulating 30 gpm at 88 ft head (38 psi), IMS Hydra enables temperature range from slightly above plant water temperature up to 250°F.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Nov 21, 2013
Featuring -20 to +200°C working temperature, Model AD07R-20 combines intuitive touch-pad operation with automatic or user-adjustable fluid optimization and ±0.01°C temperature stability to maintain buffer solutions at optimum temperatures, even under varying electrophoresis voltages. Digital system features serial and USB connectivity, 3.75 in. LCD, variable speed pressure-suction pump, and rotating control head that provides clear view of display anywhere within 180° viewing radius.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Aug 15, 2013
Designed for use with anaerobic respirometers, Model 210 Heated Circulator controls temperature from ambient to 158°F with ±0.4°F stability. Unit has 750 W heater and single speed centrifugal pump that delivers up to 3.0 gpm at 2.0 psi. Recommended for use with aerobic respirometers, ¼ hp Model 5206M Recirculating Chiller controls temperatures from 14–158°F with ±0.2°F stability. Magnetic drive centrifugal pump delivers up to 4.1 gpm at 10 psi.
Singleton DC Australia
Sep 07, 2010
Featuring stainless steel guards, motors, and brackets for complete rust proofing and cleanliness, Air Circulators are suitable for food production and processing sectors as well as chemical industry. Any components that are not stainless steel are made of inert plastic to eliminate any possibility of contamination to nearby products. Available with 460, 630, and 810 mm blade diameters, dual-speed units are supplied in fixed head or oscillating versions.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Mar 05, 2010
Designed to accommodate work habits and requirements of laboratory personnel, touch-screen operated refrigerating/heating and heat-only baths are offered with temperature ranges as broad as -40 to +200°C and temperature stabilities as precise as ±0.005°C. There are 6 different temperature controllers, including 2 programmable models, and ergonomic features include swiveling control head, integral lid docking system, and corrosion- and chemical-resistant top plate.
Taco, Inc.
Cranston, RI 02920
Mar 23, 2009
Featuring microprocessor-based, variable speed differential controller, Delta T 00 Circulator enables users to accurately calculate and adjust for heat loss because it automatically adjusts to deliver optimal heat transfer based on actual operation of system on continuing basis. Unit is suitable for use in multi-zone radiant manifolds with loop actuator and in series loop systems using zone valves.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Oct 16, 2008
With 6, 13, or 28 L capacities, Refrigerating/Heating Circulating Baths are offered with choice of controllers. Programmable Controller offers LCD display, ±0.01°C temperature stability, and time/temperature programming, while Advanced Digital Controller has variable-speed pump and RS-232 interface. Featuring 2-speed pump, Standard Digital and Basic Controllers, suited for applications where temperature set points remain relatively static, have stability of ±0.05 and ±0.2°C, respectively.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Oct 13, 2008
With working temperature range of -40 to 200°C, Model 9712 suits applications including control of jacketed reactor vessels and reaction blocks as well as polymerization, polycondensation, and distillation. It features ±0.01°C temperature stability, 13 L reservoir, and variable-speed pressure/suction pump capable of delivering pressure flow rates up to 30 Lpm. Offering data logging capability, programmable controller stores up to 10 different 50-step time/temperature programs.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Oct 13, 2008
Suited for general laboratory applications where set points seldom vary, Model 9106 Circulator provides cooling or heating for viscometers, electrophoresis cells, and other lab devices at temperatures from -20 to +150°C. It offers one-touch temperature selection, PID temperature control, and ±0.05°C temperature stability. Requiring less than one sq-ft of bench space, unit features 3 user-programmable temperature presets, 6 L reservoir, and integral 2-speed pump.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Oct 13, 2008
Model 7306 Immersion Circulator offers ambient temperature range of 5-150°C, ±0.05°C temperature stability, and 3 user-settable temperature presets for setpoint changes. It features integral 2-speed pump for internal as well as external circulation, user-adjustable over-temperature safety, and low-liquid level cutoff. Unit occupies 6½ x 4¾ in. area within bath, and is available for both 120 and 220 V operation.
Bell & Gossett
Morton Grove, IL 60053
Oct 08, 2008
Designed for domestic hot water and closed-loop heating systems, NRF-25 and NBF-25 employ 3-speed switch and motors that promote coverage for range of hydraulic capabilities. Elements of construction include DuraGlide(TM) Bearing System, heat-resistant and non-metallic closed impeller design, as well as self-cleaning particle shield. Covering multiple hydraulic settings, circulators offer flow rates from 24-45 gpm and heads from 19-33 ft. Optional check valve is available for NRF-25.
Cole-Parmer Instrument Co.
Vernon Hills, IL 60061
Oct 06, 2008
Integrating pumps, cooling systems, and heaters, Polystat® laboratory circulators are designed for optimal heat exchange efficiency, uniformity, and reservoir agitation. Digital, advanced digital, and programmable controllers are available in 6, 13, and 28 L models. Closed laboratory circulator, used for heating/cooling from -10 to +80°C, has sealed design that minimizes fluid evaporation and prevents fluid contamination. It maintains temperature to 0.1°C with flow rates to 12 Lpm.
RF Micro Devices, Inc.
Greensboro, NC 27409-9421
Apr 23, 2008
Intended for wireless infrastructure applications, PCxxxAG-21H Series is manufactured with samarium cobalt magnets packaged in aluminum housings. Units cover 5 major cellular frequency bands from 869-2,170 MHz, while exhibiting optimal intermodulation distortion performance. Offered in industry standard 1 x 1 in. packages, all drop-in circulators are lead-free and RoHS compliant.
Thermo Fisher Scientific
Waltham, MA 02454
Mar 03, 2008
Able to control temperatures from -10 to +80°C, HAAKE EZ Cool 80 is constructed of stainless steel and has bathless design that minimizes evaporation of temperature fluid during daily use. In addition to heating and cooling external applications such as analytical instrumentation, jacketed reactors, and rotary evaporators, product can also be used to replace tap water cooling in small lab applications.
PolyScience - Div. Of Preston Industries, Inc.
Niles, IL 60714 4588
Sep 20, 2007
Offering precise temperature control for range of applications, 9500 Series is available with choice of 3 controllers and integrated simplex or duplex pump. Products are capable of operating temperatures up to 200°C and provide cooling capability down to -30°C with ±0.01°C temperature stability. Model 9512 features programmable controller with LCD, multi-language help menus, and time/temperature programming. It stores up to ten 50-step programs and offers data logging capability.
Bell & Gossett
Morton Grove, IL 60053
Jun 02, 2006
Suited for residential and light commercial heating systems, Models NRF-36 and NRF-45 are equipped with 3-speed motors, which allow pumps to cover wide range of hydraulic capabilities. Units include DuraGlide(TM) Bearing System, heat-resistant and non-metallic closed impeller, and self-cleaning particle shield.
Caron Products & Services, Inc.
Marietta, OH 45750 0715
Jul 27, 2004 Low-volume, hydraulically sealed Unistat 291w provides temperature control for various critical processes and applications such as kilo labs, process research, miniplants, and production. It features cooling capabilities up to 19.0 kW with 24.0 kW of heating, and delivers efficient heating and cooling over -90 to +200°C range.
Torrey Pines Scientific, Inc.
Carlsbad, CA 92010
Jul 21, 2004
EchoTherm(TM) Model CB20 Constant Temperature Chilling/Heating Mini-Circulator is Peltier-based for heating and chilling and requires no compressors or CFCs. Temperature range is 4.0-70.0°C, accurate to ±0.1°C. Settable in 1% increments, variable pumping range is 0-300 ml/min. Circulator includes transparent reservoir cover, 3/32 x 4 in. stainless steel platinum RTD probe, 3 ft cable, and RS232 I/O port for computer control or data logging.
Airmaster Fan Co.
Jackson, MI 49203
Feb 23, 2004 Heavy Duty Air Circulators are available with 3-speed, 115 V, oscillating and non-oscillating motors and single-speed, 3-phase explosion proof motors. Propeller produces low noise levels and is self-cleaning due to highly polished surface. Complete selection of mounting accessories is available.
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The Entrepreneurial Spirit, a Tribute to My Father
Published on - July 21st, 2006 (Modified on - July 22nd, 2006) (by J.D. Roth)
My father was an entrepreneur. He was always starting businesses. He was always selling things.
When I was very young he operated Steve's Lawnmowing Service. He also sold World's Finest Chocolate. He carried boxes of chocolate bars with him to church, and sold them after Sunday School. I remember standing on the church lawn, waiting while Dad joked and told stories and sold candy.
He tried lots of other things, too: he was a flight instructor, he sold Shaklee, he raised nursery stock. He read personal finance books. (The Richest Man in Babylon was one of his favorites.)
Dad's first real entrepreneurial success came with Harvest Mills, which he started in the mid-seventies. He built a wheat grinder from scratch. He liked it so much that he decided to sell them. He developed a system for manufacturing them in a production line. Then, further capitalizing on the health-food craze, he developed the Little Harvey food dryer. These sold well, and soon he had purchased one of the first plots of land in a new industrial park. Harvest Mills was a success.
Dad sold the business in the late-seventies for a large sum of money. For reasons that are no longer clear to me, he never saw full payment for the business. (My memory is this: he sold Harvest Mills for $300,000 payable in ten yearly installments, but the buyer went bankrupt and somehow only one payment was made. Dad, who always had poor personal finance skills, squandered what money he had been paid on airplanes and sailboats, his expensive toys.)
The next six or seven years were tense. The economic outlook in the early eighties was poor. Dad moved from one sales position to another: selling staples, selling industrial supplies, selling boxes. He started other businesses: an accounting service (with software that he wrote in Microsoft Basic on an Apple II), a nursery (again), a wood stove manufacturer. These all failed.
On his fortieth birthday — 31 July 1985 — Dad left his job as a box salesman and founded what would become his greatest success: Custom Box Service. He worked night and day to create a business that could exploit a marketplace niche. He sold the boxes. He designed the boxes. He made the boxes. He delivered the boxes. He did the accounting. He lived and breathed boxes for a decade. One-by-one his three boys came to work for him.
Dad died ten days before the business's tenth anniversary, ten days before he would have turned fifty years old. Cancer ate his body, consumed his will. He left behind an unconventional inheritance: no money to speak of, but a growing, thriving business.
For the past eleven years, his children (and a nephew) have kept this business running. It now sells well over a million dollars a year. But none of us are entrepreneurs. We don't have that spark. Sometimes I sense a glimmer of it inside myself, but in order to prosper as an entrepreneur, you need chase a dream that you believe in one-hundred percent. Boxes are not my dream.
When I was a boy, Dad tried to foster my entrepreneurial spirit. He encouraged me to sell seeds from a magazine, but I was too shy to knock on doors. I also failed at selling greeting cards. He tried to teach me to peel chittum bark that could be sold to god-knows-where for use as a natural laxative. (He had done this himself to earn money as a boy.)
Sometimes, if I were personally vested in the enterprise, I relished buying and selling things. In fourth grade, in order to generate money for new comic books, I took my old comics to school and sold them. I took my Star Wars trading cards and repackaged the doubles, selling each thick bundle for twenty-five cents each. I sold my old Hardy Boys books to buy new ones.
Now, for the first time in twenty years, I'm beginning to feel a bit of the entrepreneurial spirit. I have an idea, a plan, a vision.
I am now ready to become an entrepreneur, too.
Thanks, Dad.
31 July 1945 – 21 July 1995
This is how I like to remember Dad: busting a gut over something.
This article is about Entrepreneurship, Real-Life
So what's your business? Does it have to do with this blog, or unrelated? I love to hear entrepreneurial stories–are you going to give a blow-by-blow of what you're doing? That would be pretty cool.
Awesome story about your dad by the way. I lost my dad at a young age, too–he was also the entrepreneurial type, and refused to save a penny. I like to think my various entrepreneurial ventures came via his genes. (Luckily I didn't inherit his spending ways.)
I just quit my job last week to work full time on starting my business. I've been wanting to for about 2 years, and finally saved up enough money and gumption to have a go at it.
Maybe I'll try to save some money for my kids though.
J.D., it's awesome of you to remember your Father on such a day. If he didn't leave a conventional inheritance to you guys, he left one hell of a legacy. Don't ever forget that.
[...] Michael writes: "I just quit my job last week to work full time on starting my business. I've been wanting to for about two years, and finally saved up enough money and gumption to have a go at it." Outstanding. Best of luck, Michael! [...]
Your dad sounds like he was a great man and a truely inspirational character.
[...] parents didn't teach me money skills. My father taught me the entrepreneurial spirit, but his other money habits were irresponsible. What I know about money came from books, and from [...]
[...] my father, Keith's dad ran his own business. Both men passed a sense of entrepreneurship on to their [...]
[...] my father was a serial entrepreneur, I've spent most of my life around small businesses. Chris and Nicole have had a taste of the [...]
Great post. How you're raised has a lot to do with it. Losing your father at a young age probably gave you some tough skin – which every entrepreneur inherently needs. Your dad probably didn't make a ton of money doing what he did – but sounds like he enjoyed every step of the way.
[...] is the surest path to failure. You cannot succeed if you never try. My father used to tell me this, but I never took his advice to heart. I became an expert at doing nothing, at [...]
[...] the entrepreneurial spirit – Find someone with an entrepreneurial spirit to look up to and follow their lead. For me, having one or more role models is very [...]
I worked for your Dad at Harvest Mills during my senior year of high school and for a couple of years after that (as I recall).
He was a good boss and I enjoyed working there, so I was quite dismayed when he sold the business and it was moved to Utah. As lead man of the assembly line, I was the last of the hired help kept on to the dreary end. I remember going to the shop and foreman Jerry and I being the only souls there.
I've often looked back on those days and that job with a certain degree of wistfulness. I enjoyed reading your post here.
I salute your father. And your Uncle Norm.
You're lucky that you knew your father and that he encouraged you in many ways (even if it wasn't a good fit).
I know my father but his unique qualities are… unprintable!!
A friend of mine gave me a flour mill several years ago. This morning I was curious about the maker. The little brass plaque on the front says, 'Harvest Mills, Canby Oregon.' I googled the name and place, and found this article. Thought you might like to know there is a mill still going strong in Beaverton.
Best Regards, Stacey


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And Lawrence Hurley of Reuters reports that "U.S. justices agree to hear challenge to Ohio speech law."
Posted at 11:18 PM by Howard Bashman
In other coverage, The Associated Press reports that "Court upholds approval of BP oil spill settlement."
Bloomberg News reports that "BP Oil-Spill Settlement Approval Upheld by Appeals Court."
And Reuters reports that "U.S. appeals court affirms BP settlement in 2010 Gulf oil spill."
Posted at 10:57 PM by Howard Bashman
Update: In other coverage, at "The BLT: The Blog of Legal Times," Tony Mauro has a post titled "Supreme Court Grants Review in ABC v. Aereo Showdown."
Posted at 03:44 PM by Howard Bashman
In early news coverage, The Associated Press reports that "Court to rule on television over Internet service" and "High court takes POM Wonderful, Coke label fight."
Greg Stohr of Bloomberg News reports that "Broadcasters Get U.S. Supreme Court Review in Bid to Stop Aereo"; "Argentina Gets U.S. Supreme Court Hearing in Bank Case"; "Technology Patent Case Accepted by Court at Google Urging"; and "Coca-Coca Pomegranate Drink Targeted in High Court Case."
Lawrence Hurley of Reuters reports that "U.S. top court agrees to hear broadcasters' case against Aereo"; "U.S. top court agrees to hear Argentina bank subpoenas case" and "U.S. high court agrees to hear Coca-Cola labeling dispute."
And at "SCOTUSblog," Lyle Denniston has a post titled "Court grants eight cases."
Posted at 03:12 PM by Howard Bashman
In other coverage, Charlie Savage of The New York Times has a news update headlined "U.S. to Recognize Utah Gay Marriages Despite State Stance."
And Brooke Adams of The Salt Lake Tribune has a news update headlined "Feds recognize same-sex marriages in Utah; U.S. Attorney General says couples 'should not be asked to endure uncertainty regarding their status.'"
Posted at 12:03 PM by Howard Bashman


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Categories > Cartoons > Class of the Titans > Vengeance: A Dish Served Cold
Cronus Attacks1 Reviews
Stacy finds herself in a world of trouble when she runs into Cronus...R&R Please and Thank you!
Vengeance: A Dish Served Cold
(#) Riane46 2007-07-13 11:35:27 PMI read it on ff.net and reviewed it, too. It was good.
Author's responseThanks :) I'm glad you are enjoying it.


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Performance artist Marina Abramovic has launched a Kickstarter to create an Interdisciplinary Performance and Education Center
An institute for the benefit of all is best funded not only by a few large donations, but also by smaller contributions from the people it will serve, who can then share in its creation. After paying for phase zero, Abramovic is turning to the public to join her in funding phase one of Marina Abramovic Institute, dedicated to the presentation and preservation of long durational work, including that of performance art, dance, theater, film, music, opera, and other forms that may develop in the future. MAI will foster collaboration between art, science, technology, and spirituality, bringing these fields into conversation with long durational work. We will also provide an educational space to host workshops, lectures, residencies, and research.
Abramovic aims to create a global community of collaborators, and wants anyone who supports the project conceptually to be able to contribute to it financially. We are using Kickstarter, a platform that will allow us to communicate directly with future visitors, and to offer rewards that engage them in our mission. By inviting the broader public to contribute to the early development of MAI, Kickstarter helps to affirm and build the engaged community necessary for sustaining the institute into the future.
Some of these rewards include an 8-bit video game version of the institute called Digital MAI ($5), access to live stream demonstrations of Abramovic Method exercises led by the artist herself ($25), or mementos that celebrate the early stages of MAI's development, such as architectural design materials from OMA ($50). One experiential reward is pre-registration for a ride in the compatibility racer, a brain-powered cart developed by neuroscientists for future installation at MAI ($250). At higher levels, backers can select to workshop their project via webcam with Abramovic, or attend an event and lunch in New York City with the artist.
If this initiative succeeds, backers will have helped to found both the largest cultural institution ever to get off the ground using Kickstarter, and the only project of its kind in the world.
KICKSTARTER LINK: http://kck.st/15kYWJe
Tweet: @hudsonMAI
Facebook: Marina Abramovic Institute
In 2010, MoMA presented a retrospective of Marina Abramovic's work, The Artist Is Present. For many people, one of the most memorable parts of this exhibition was the opportunity to sit with Abramovic during her performance of the title work. The artist is interested in gathering information about visitors' experiences of this performance, and is putting out the call below:
Did you sit across from Marina Abramovic or wait in line to do so during The Artist Is Present (2010) at MoMA? If yes, she would like to hear from you. E-mail firstname.lastname@example.com with subject line 'PRESENT' for more information.
Join in this collective effort to capture the experiences of the work, and keep an eye on the artist's ambitious current endeavor: creating The Marina Abramovic Institute in Hudson, New York!
snaps at a signing
last night was Marco Anelli's book signing for Portraits in the Presence of Marina Abramovic at Danziger Gallery where a small group of the photographs are on display in the project room.
congratulations Marco!!!
it's only taken a year to post this, but i really think it's brilliant
confession: i've started to play it a number of times, but have never gotten to sit.
i'm playing now and i'll come back with an update if i make it through.
a blog post from the game's designer
questions/comments or just ask me
MoMA interactive: portrait slideshow


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[Note: Before Midnight is an especially difficult movie to write about, simply because for some people, even what has become of Jesse and Celine since Before Sunset is information that they don't want. But it's impossible — absolutely impossible — to write about the movie without talking about where they stand and what the premise is. I did my absolute best to spoil as little beyond that as possible. But if it's extremely important to you not to know whether he missed the plane, whether they've seen each other in the last nine years, or the rest of the table-setting that happens in the film's first few minutes (and if you've managed not to know until now), stop here.]
It took three movies for the stunning series made up of Before Sunrise, Before Sunset and now Before Midnight to go back to the beginning.
And what was the beginning?
In 1995's Before Sunrise, directed like the other two films by Richard Linklater, Jesse (Ethan Hawke) and Celine (Julie Delpy) spend a single romantic night together in Vienna. But that's not the beginning. Before they can spend that night together, they have to get off the train together. And before they get off the train together, they have to talk. And before they talk, they have to meet. And before they meet, that's the beginning.
Remember? They're on the train, and Celine gets up from her seat and moves, ultimately plunking herself down right across from Jesse and going back to the book she's reading. And he spots her out of the corner of his eye, an impossibly beautiful French girl, and he makes a little goggle-eyed smile into his book, because it's all just a little too unreal.
But that's not actually the beginning either.
In the very beginning, the reason Celine gets up and moves is that the middle-aged couple sitting near her is fighting in German, and she's tired of listening to it, even though she can't understand it. She winds up next to Jesse specifically because she's quietly but firmly put off by the ugliness of couplehood that's been corroded by years of togetherness; by familiarity that has bred contempt. The first conversation they ever have is about that couple, and the fact that Celine has heard that in time, couples literally lose the ability to hear each other — men lose their hearing of higher tones, and women of lower ones.
It took three movies and 20 years for Jesse and Celine to be the ones having the fight, and to worry that now that they've passed 40, they are becoming the couple they ran away from when they'd just passed 20. It's not hard to reshoot that scene in your mind's eye, with the 2013 Jesse and Celine fighting in the foreground while, in the background, the 1995 Jesse and Celine huddle to roll their eyes at those people who can't hear each other.
See, it turns out Jesse really did miss that plane at the end of Before Sunset, and he never really went home. They've been a couple ever since, and they have twin daughters, conceived shortly after they got together. His son and ex-wife live in Chicago and he's published more books; she's still a professional environmentalist. We meet them here in Greece, at the end of summer.
And they've learned, perhaps unsurprisingly, that if you think being separated for nine years is hard, you should try being together. Their relationship, originally so perfectly preserved and gorgeous in memory, has gotten scuffed and noisy and complicated. It's not just the two of them in a listening booth in a record store now. It's them and their daughters, and his son, and his ex-wife, and their friends, and their work, and ultimately everybody with the ability to intrude, which is … everybody.
The neat trick of Before Sunrise was that as between the two of them, there were no obstacles for Jesse and Celine. They were perfect according to each other's greedy and generous interpretation. Everything that happened made them like each other more; every conversation they had made them seem more mutually well-suited. It's an almost perfect document of the intoxication of first meetings, of the sense that every time your phone wasn't ringing, this is the person who was supposed to be calling you, and every time you felt a space next to you, this is the person who was supposed to be in it.
The obstacles were simply guts and time; he had to get on a train in the morning so he could catch his flight home, and if they weren't going to get lost, somebody would have to find the nerve to say something before they parted. (Note, if you are under 25: we didn't have Skype or smartphones or Facebook then, so sometimes people we really liked got lost. P.S. Looking for them is one of the first things we did with Google.)
In the break between the first movie and Before Sunset, the big lingering question was whether they kept their promise to meet again six months later so they wouldn't get lost. The answer? They didn't. Life had intruded, and they'd gotten lost. That second leg of the story started with a broken promise, which announced that we were in a different place with these two. They knew more; more had happened to them. Still, they fell instantly into those same talks and walks. The obstacles were still external but more complex — professional obligations, other relationships, timing, geography, and the assorted bullpucky of life that keeps most things from ever happening. They had the opportunity to take a regret and transform it into a rescue, it seemed.
But now they are over 40. They have children. They have outgrown the question that clearly was on their minds when they were in Vienna: Is this meant to be? Now, there's no such thing as "meant to be." Now, there's only whether or not they will keep trying.
Before Sunrise was a perfect little romance, and Before Sunset an equally impressive if less unexpected artifact, like a comet's tail. But when you see Before Midnight, it seems like it could all have only been leading to this story, and to these conversations.
This is a love story, as it turns out, rather than a fairy tale. And in a real love story, the roles of destiny and fate and chance, all of which are critical in Sunriseand still present in Sunset, fade over time, to the point where what's left is a bunch of choices, most of which are variations on a single theme — is this worth it? First it was magic, then it was a thicket of circumstances, now it's exhausting work and ultimately the weighing of options.
In a perfect inversion of the way we first met them, Jesse and Celine have all the time in the world in Greece. They can wander all they want, have all the sex they want, and certainly talk all they want. Nobody has a train to catch or another relationship; nobody has a reason to leave at all. Everything that makes it hard is in the room with them, not outside. And the writing plays fair, because everything that's in the way has been there from the beginning: she can be stubborn and defensive; he can be mean and dismissive when he thinks she's being irrational. (Remember the palm reader?) He's a sometimes tiresome writer; she's a sometimes self-righteous complainer. And all of that, or at least the groundwork for all of that, was there in Vienna and in Paris, and now it's there in Greece. It's not happy that scruffy youth often matures into embittered middle age, or that the young guy with a funny idea about a 24-hour-a-day cable-access reality show becomes the older guy who won't shut up about his high-concept book project, but it's fair.
But perhaps what's richest about taking these three films together is circling back to Jesse and Celine as nervous twentysomethings and seeing how filled with anxiety they were about the future. He dreaded being a bad father, she dreaded being stuck with a man who wanted to change her, and they both feared that they were doomed to become boring and sad and dead inside and that they'd lose the ability to feel like they did in that strange little bubble. When she asked him whether he knew any happy couples and he said he did, but he suspected them of lying to each other, it didn't seem at the time like they were talking about whether they could ever be happy, but now it seems like they were.
Back then, Celine told Jesse a story of her grandmother spending her life with a man other than the one she really loved. Jesse assures her the other guy would only have disappointed Grandma. "People have these romantic projections they put on everything," he tells her, "that's not based on any kind of reality."
They talk compulsively in that first movie about what will happen later — he coaxes her off the train by telling her she'll be glad she did it in 10 or 20 years. She wonders what he'll say about her years from now if they have sex on the one night they're together. They rehearse the conversations they'll have about each other. They wonder whether their little bubble might survive in daylight: he says, barely knowing her, that if his only choices were marrying her and never seeing her again, he'd marry her. But that's crazy, of course. You can't do that, of course. When it's morning, you get on the train, because that's what you do. Daylight intervenes.
And now that we know what was coming, nine years later and then nine years later, Sunriseis like a six-sided die turning into a 20-sided die. Those kids, that floppy-haired boy and that willowy girl, would be so glad if they knew what was coming, and so sad, and so scared, and so relieved.
It's not that there's never been a story told about the maturation of a relationship over years, but there is something about the way they executed these films, in real time, that cannot be duplicated with makeup. People age unpredictably — if you tried to dress up as You In 20 Years, you would fail, because there's a mystery to whether faces get craggier or softer or fuller, and to how women's hips change when they have kids. This is why people go to high school reunions: everyone is a forward projection brought to life. You are more in the past than in the present, a time traveler sent back to tell yourself who went gray first. The Before movies, taken together, are a trippy knot of consequences and anticipation, where seeing the last one makes you want to watch the first one and seeing the first one makes you want to watch the next one, because they all mean more as pieces than alone. Before Midnight is the flawed future of those kids in Before Sunrise; Before Sunrise is the bittersweetly remembered past of that couple in Before Midnight. There's a sense of forward and backward motion, because they've been truthful about the fact that everything looks one way now and a different way later.
Before I went to see Before Midnight, I watched Before Sunrise and commented that it was startling, even as someone who's seen it many times, to see how young they really were. And someone pointed out something remarkable to me: For those of us who were roughly the same age as Jesse and Celine, it's not that we don't remember how young they were; it's that we never registered how young they were to begin with, because we didn't register how young wewere.


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Valentine's Day: the top 30 celebrity kisses!
The Duke and Duchess of Cambridge
Prince William and Kate Middleton are one of the world's favourite couples, so it's great that they're happy to give everyone what they want: a public kiss now and then!
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Sales on a global basis (including overseas subsidiaries) grew 13.8% to KRW 14.497 trillion (approx. US$11.229 billion) year-on-year. Operating profit jumped to KRW 1.133 trillion (approx. $878 million) resulting in a margin of 7.8%, which is 1.1% higher than the previous year. On a parent basis the company recorded sales of KRW 8.477 trillion (approx. $6.566 billion) and an operating profit of KRW 714 billion (approx. $553 million).
Home Appliances
The Home Appliance Company reported an increase of 9.8% to KRW 2.339 trillion (approx. US$1.812 billion) year-on-year. Currency impacts resulted in sales declining 14% on a USD base but growing 10% for Korean won.
Continuing problems in the housing market slowed the pace of recovery of the home appliances industry. LG credits the competitiveness of its products with helping it achieve an operating margin of 7.7%, 2.9% higher from a year earlier, at KRW 181 billion (approx. $140 million).
Looking at the third quarter, market demand is expected to shrink year-on-year due to the ongoing recession, but that decline is expected to slow down.
LG's Air Conditioning Company saw sales rise 1.8% to KRW 1.720 trillion (approx. $1.332 billion) year-on-year with sales falling in U.S. dollars but increasing in Korean won. Operating margin resulted in a profit of KRW 175 billion (approx. $136 million) due to the growth in demand for premium models.
Despite the recession, LG foresees its market share growing in the third quarter in Korea, Europe, Australia, and other markets in the southern hemisphere, thanks to more energy efficient commercial air-conditioners and inverter-embedded residential products.
Other LG Businesses
The Home Entertainment Company saw sales rising by 19.3% to KRW 4.509 trillion, for a profit of KRW 224 billion (approx. $174 million). Flat panel TV sales were robust, particularly LCD TVs, and shipments rose 45% year-on-year to 4.28 million units.
The Mobile Communications Company reported KRW 5.140 trillion (approx. $3.981 billion) in sales, up 25.8% over the previous year, and operating profit of KRW 545 billion (approx. $422 million). Handset sales were up 29.9%. Shipments of handsets recorded an increase of 7.8% year-on-year and 32% quarter-on-quarter to 29.82 million units. With the global economic downturn expected to continue, LG expects the global handset market to decline more than 6% to about 280 million units in the third quarter, but expects its own shipments to continue to grow.
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