text:
The concepts behind EpiDoc bring together, for epigraphers, traditional and entirely modern editorial methods and conventions.
Over the last century, epigraphers have wrestled with the issues involved in representing non-verbal information within their written texts. Until the end of the 19th century publishers could be expected to produce a facsimile of the text, but this became decreasingly common, and publishers did not demonstrate a parallel willingness to provide a full photographic record of every text. The conventions which have been painfully developed to indicate missing text, abbreviations, etc. have been more or less generally agreed since the 1930s and overlap, to some extent, with those used in papyrology and palaeography. All epigraphers have had to deal with the issues involved in moving this to an electronic environment - for example, finding a font which will permit underdotting; but most of us have now adjusted to these new constraints.
The difficulty of rendering such conventions and, in particular, Greek characters in consistent fonts and on the Web has tended to delay the publication of full epigraphic texts online; instead, enormously rich search collections have been created, most notably:
All these developments have therefore been determined by the state of the existing technologies, as these have evolved over the 20th century. The object of EpiDoc is to exploit new and rich technologies for the traditional purposes of epigraphy. Many of the processes described above have involved struggling agaist the technological standards - for example, in print publications - in order to accommodate as many of our requirements as possible. Over the period it has become steadily more difficult to persaude conventional publishers to meet our requirements for inserting meta-textual information, unless at prohibitive expense. At the same time, the expectations as to the volume of information which should accompany a text have risen greatly; as well as information about physical circumstances, photographic illustration has become standard.
In the last 15 years scholars generally have been dealing with similar requirements to incorporate meta-data within texts in their electronic form, and tools have emerged which make this increasingly easy and make the results increasingly valuable. The word-processing software that has been familiar since the 1980s allows us to control the formatting of our texts, using markup which by now is invisibly embedded by the software. The more demanding requirements of large-scale document collections - legal papers, industrial documentation, commercial publishing - led in the 1980s to the investigation of ways to insert a wider range of information and instructions within electronic texts. At first the emphasis was on inserting formatting instructions, but there soon emerged methods of including more complex semantic information concerning document structure and even content. A simple example is marking up a book title as a title, rather than simply marking it as being italicized. The use of this more abstract markup permits a separation of structure and presentation, where structure is comparatively fundamental to the document's genre, while presentation may be varied depending on the form of publication. In a way, this shift represents a return to an earlier mode in which authors dealt with the substance of the text and all details of presentation were handled in the publishing process - a distinction which has been lost in the days of camera-ready copy.
The protocols which emerged from this latter effort were standardized in the late 1980s as the Standard Generalized Markup Language, and more recently were given a simpler and more flexible form for use in the world-wide web as XML: the
The attractions of XML for epigraphers are therefore considerable. For example: missing material can be marked up as such, and then presented within square brackets; at the same time, a search can be instructed only to interrogate text which has not been marked up as missing (so only definitely attested terms). Uncertain letters can be marked up as such, and a decision made later as to whether to render them with an underdot or in another way. Words can be lemmatised during editing, to create indices which grow as the collection grows. What is important, however, at this juncture is to repeat the 'Leyden' exercise; that is, to agree electronic equivalents of the various sigla that we use. Firstly, this is valuable simply in order to save time and trouble; but also consistency - without imposing uniformity - continues to be valuable. Not only does it support the user, as on the printed page; but documents edited in this way and published electronically will then be exploitable together, even if they have been prepared separately.
The need for agreed standards is not limited to epigraphy. Since 1987 an international consortium of scholars principally in the humanities has been working together to develop and refine a set of guidelines for describing the structure and content of documents. The results of this endeavour have produced an encoding language, realized in XML and described by the name of the group - TEI, the
The Text Encoding Initiative is a research effort aimed at defining an encoding language that encompasses the needs of humanities scholars very generally. There are two essential goals motivating the development of the TEI. The first is to enable scholars to represent their research materials in digital form using a descriptive language that mirrors the kinds of analytical terms and concepts that are familiar and essential to humanistic scholarship. The second goal is to enable scholars to share the resulting materials intelligibly, by using a common descriptive language.
We can think of the TEI encoding language as resembling a human language: a core of shared terms at the center, surrounded by less widely shared vocabularies including local usage, specialized terminology, and other variations. At the core of the TEI are the common terms and concepts that are broadly shared by scholars in most disciplines: features like paragraphs, generic textual divisions, headings, lists, and so forth. More specialized elements are grouped together according to their applications: for instance, elements for detailed encoding of names, elements for representing features of manuscripts, elements for capturing the structure of dictionaries, and so forth. The TEI is intentionally organized into modules in this way, so that scholars working in specific disciplinary areas may use only the modules relevant to their work, and omit the others. The TEI can thus achieve a great deal of breadth without burdening individual scholars and projects with the necessity of mastering a very large domain, much of which is only relevant to other disciplines. On the contrary, the TEI encoding language can be very directly targeted at a specific domain or task, and can be limited to what is essential to the individual project's work.
Like a human language, TEI can be used in a way that draws on a rich and nuanced vocabulary, with detailed encoding that describes a great many textual phenomena, but it can also be used very simply, using only a few essential concepts that describe only the most basic textual facts: sections, headings, paragraphs. The more detailed the encoding, the more one can do with it, but factors such as time, cost, available staff, and local expertise may place constraints on the level of detail that is feasible.
In addition to providing an encoding system that scholars can use in its original state, the TEI also provides a way for scholarly projects to define custom versions of the TEI language which include modifications that are necessary to support specific local needs. Because these custom versions operate within the overall TEI framework, they can use its broadly shared core of terms and concepts, thereby avoiding unnecessary work in reinventing these. And because the TEI provides a common framework for creating and describing customizations, these can be shared easily and meaningfully. As a result, groups of scholars in particular disciplines can articulate the specific goals and methods which characterize their work, and the differences which distinguish them from others working in related fields. Instead of mutually unintelligible approaches, different projects can produce results whose differences result from real disagreements rather than simple random divergence.
Within this framework, the
To accompany the EpiDoc encoding language, the EpiDoc community has also produced a set of
The group has worked to develop expressions for all the
Further areas under active exploration include developing interoperability. A software tool for converting texts in normal epigraphic markup into EpiDoc XML has already been developed (the so-called
The work, led by Dr. Elliott, has been undertaken by various individual scholars working in close collaboration, and in regular contact with the wider profession. They have drawn on the experience of an established EpiDoc project, the
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Monterey to Imperial Flights
Monterey and Imperial airports and terminals
Airports in Monterey CA, US
Monterey Peninsula (MRY)
Distance from City Center: 2.8 miles
San Jose International Airport (SJC)
Distance from City Center: 52.1 miles
San Francisco Airport (SFO)
Distance from City Center: 75.3 miles
Airports in Imperial CA, US
Mexicali Airport (MXL)
Distance from City Center: 15 miles
Imperial County (IPL)
Distance from City Center: 0 miles
Cheap flights from Monterey to Imperial
Highlighted price = Cheapest round-trip flights
Prices are round trip per person (conditions apply)
Featured Imperial Airport Hotels
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Flights to Imperial
Monterey, CA, Airport Information
When looking for sales on flights from Monterey, use Orbitz.com to save time and money. It will compare the rates of all major airlines providing service to the airport, allowing you to choose the best rates and options for your needs and budget. The Monterey Regional Airport provides air service for Monterey. It is located at 200 Fred Kane Drive and is about four miles from downtown Monterey. Several airlines provide service to the airport, including Alaska, American, Allegiant, United, and US Airways. Orbitz.com will compare the rates of these airlines, providing you with the best rates available.
Airport Parking Information
Short-term, long-term, and disabled parking are available near the airport terminal. The short-term rates are $2 for 30 minutes, with a maximum rate of $20 per day; the long-term and disabled parking rates are $1 for 30 minutes, with a maximum rate of $10.00 per day. Payment can be made by cash, check, or major credit card when exiting the lot.
Transportation to the Airport
Transportation to the airport is available by taxi, public transportation, or car rental. The Monterey Salinas Transit bus will cost about $2.50 from downtown but will take longer to reach the airport. Taxi rates are metered and vary slightly by company; there is a $3 surcharge added for airport passengers. Car rentals vary by company and type of vehicle chosen. Alamo, Avis, Budget, Enterprise, Hertz, and National car rental companies are located at the airport for your convenience. Orbitz.com works with these companies to bring you the lowest rental rate available.
Airport Restaurant Information
Hungry travelers have a few options at the airport, including the Golden Tree Restaurant, Fly Away Cafe, and the Golden Tee Snack Bar. Whether you want a snack or a sit-down meal, these restaurants provide a wide variety of food options. When you are searching for sales on flights from Monterey, check with Orbitz.com for the best rates and options available, and save some time and money.
Imperial County Airport
Imperial is a city located in Imperial County in the southernmost portion of California. It is a popular tourist destination with a wide variety of things to do. Orbitz.com can help travelers find discount flights to Imperial. The Imperial County Airport is located approximately a mile from downtown Imperial on Airport Drive. United Express offers flights to Los Angeles from the airport.
Transportation from the Airport
A popular method of travel from the Imperial County Airport is by rental car. Orbitz.com can help locate car rental agencies in the area. Shuttle vans are an inexpensive way to travel from the airport to various locations in the city, including most major hotels. Private-ride vans are another alternative for large families or groups, and limos are available for rent by the day or by the hour.
Average Weather in Imperial
Imperial, California, has a hot desert climate. It is one of the hottest cities in the United States with average summer temperatures around 110 degrees Fahrenheit. Winter temperatures are around 70 degrees Fahrenheit.
Things to do in Imperial
The Pioneers Museum is located near the beach and has a wide variety of exhibits featuring artifacts from the area. The Barcelona Event Center is located just five miles from the city center and is host to a wide variety of concerts and events throughout the year. Orbitz.com can help travelers locate discount flights to Imperial.
More to explore for Monterey to Imperial
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 48 hours. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

subset: commoncrawl


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By Jack Presscot: Apollo Creed, in the very first, Oscar winning Rocky movie was in his office, looking up opponents with his trainer and his promoter. They were going over a list of potential opponents, but none of them seemed to faze Apollo, who seemed bored with the names, until he found the perfect match. "This guy, heres our guy!" To which the promoter says "Balboa? His record's poor", and Apollo disagreed. "The name....The Italian Stallion"...and after pondering it a minute, thinks aloud...."Apollo Creed vs. the Eye-Tallion Stallion....sounds like a damned Monster Movie."
It is basically the same concept with Julio Cesar Chavez Jr. His record is not poor, but he really has beaten nobody special. He is not a current or former World Champion. But what a hell of a name, and an opponent for Oscar de la Hoya's final fight. In 1996, Oscar de la Hoya and Julio Cesar Chavez fought in a fight deemed "Ultimate Glory" and had the attention of the entire boxing world, as the beloved Golden Boy of Boxing took on the Patron Saint of Mexico for the WBC World Title at jr. welterweight.
The fight did not live up to all the hype, as Julio was cut in the first round by an Oscar stinging jab, and the cut led to the stoppage a few rounds later, as Julio looked like a murder scene victim. (Was it Julio Jr. who bonked heads with his daddy earlier in the week?) The Chavez camp stated that the cut was due to an accident involving one of Julio's sons, and this tainted the victory for Oscar de la Hoya. 2 years later, the fight deemed "Ultimate Revenge" happened in September, Oscar and Julio put on an interesting toe to toe war for several rounds, until a de la Hoya uppercut caused the inside of Chavez' mouth to bleed uncontrollably, and led to a stoppage.
Julio finally gave Oscar congratulations for defeating him. Oscar had indeed defeated the Patron Saint of Mexico, but this caused him to be generally hated by the Mexican fans he had hoped to get on his side. So hated, that in his autobiography, "American Son" he speaks of being Grand Marshall of a Parade in LA and getting jeered and pelted with rotten fruit, all because he had defeated Chavez.
10 years later, and the son of Julio is now 38-0, and needs a big name after the Vanda rematch. Oscar de la Hoya finds himself without a final opponent for his career, as Manny Pac has told him that the 70-30 offer was unacceptable. Oscar is now calling out Sergio Mora, but nobody outside of LA knows who Mora is. If this fight is held in the Staples Center, on HBO WCB, perhaps it will be successful, but it is certainly not worthy of PPV status.
But a de la Hoya-Chavez Jr. fight would be huge, and a shot at final redemption for the Chavez family. If Julio Jr. takes 6 months to prepare and comes in at a ripped 152, for this jr. middleweight bout, and spends many countless hours running in high altitude mountains, and learning how to block, dodge and parry punches from a defensive specialist, he stands as good a chance as anyone against an Oscar de la Hoya who is pushing 36 years old, and had already began to show his age against Pretty Boy's sparring partner, little Stevie Forbes. And in this fight, Julio Jr. cannot be stubborn like Manny Pac was holding out for huge dollars. As green as Chavez still is, he would probably agree to fight Oscar for free, just for a shot at revenge for his father.
Pavlik May Kiss The Canvas But He Will KO Hopkins
By Jim Amato: Ever since it was announced that Kelly Pavlik was going to meet Bernard Hopkins, I've felt that this would be a tough fight for Kelly. I still do. I've really thought about this fight. I've tried to break it down to its likely conclusion. Here goes...
Pavlik depends on pressure. He applies it from the opening bell until the end. Bernard is famous for his stalling tactics but he will find Kelly a hard man to discourage. In a nut shell, Pavlik will not dance to Bernard's tune. Kelly will set and dictate the pace of this fight. This is not good news for Bernard's aging legs and often weary arms. To Hopkins credit he is a crafty old coot. He will have a plan B.
One of Bernard's best assets is his counter punching ability. He is a very cunning fighter. Kelly likes to work behind his jab and then throw long, lethal rights to the head and body. He likes to get full extension on that right to generate maximum power. When Kelly wings the right he is not in the best position to defend himself. Hopkins has a great counter left hook and Pavlik may be opening the door for Hopkins to land it. To me this is Bernard's best chance to win the fight. Possibly the only chance.
It will not surprise me if Hopkins puts Pavlik down somewhere in the first five or six rounds. It also won't surprise me when Kelly gets back up. What will surprise Hopkins is the great tenacity of the young man he is fighting. I feel Kelly will have a slight lead over the first half of the fight because of his work rate. I do expect Bernard to have his moments though.
As we get into the second half of the fight the momentum will change at an accelerated rate. You have all heard the adage "a fighter can grow old overnight." By this point of the battle Bernard will begin to feel the effects of the pressure. Pavlik is not shy about going to the body and it will be around this time that those thunderous body blows in the earlier rounds sap the spring in Bernard's time worn legs. His arms will no longer obey his command to throw combinations. A one punch at a time output is a bad recipe when facing a youthful gunslinger like Pavlik. Hopkins will begin to take inhuman punishment. His great pride will not allow him to fall. Either pride will finally be overpowered or a merciful referee will step in. Succumb he will to the young lion before him. On this night, one legend will end and another will begin.
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Liver-Related Information
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Home > Divisions > Great Lakes
The American Liver Foundation Great Lakes Division works continually to fulfill our mission to facilitate, advocate and promote education, support and research for the prevention, treatment and cure of liver disease. Join us at our Liver Symposium, host one of our Core Educational Programs in your workplace or community, and get involved in our fundraising and patient advocacy events as we work towards a world without liver disease.
On October 25, 2014, the American Liver Foundation Great Lakes Division is hosting a free, CME accredited symposium open to healthcare professionals and the general public. The Liver Symposium will bring together leading experts in the fields of gastroenterology, hepatology, transplant surgery, and infectious diseases to speak about current liver disease topics. There is no cost associated with participation, but you must be registered to attend. Click here to register and learn more about the program.
The American Liver Foundation Great Lakes Division offers three public health educational programs on liver health and liver disease topics, delivered free of charge to our community by trained volutneer educators. Click here to learn more about our local educational programs, and find out how your workplace, community organization or local school can host one of these programs.
Rebuttal letter from the ALF GLD Medical Advisory Committee to the Illinois Department of Healthcare and Family Services regarding hepatitis C treatment criteria for Medicaid recipients.
Illinois-Letter to Illinois Department of Healthcare and Family Services - 9/15/14
Register to be an organ donor at Gift of Hope
The American Liver Foundation connects individuals with liver disease to the financial assistance resources they may need. More
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Leadership, integrity, vigilance, excellence and respect guide our work every day. Read more…
The American Liver Foundation Great Lakes Division is part of a growing group of organizations joined to combat the skyrocketing out-of-pocket costs insurance companies place on lifesaving medications for people with chronic diseases. The Illinois Coalition for Access to Affordable Medication is on a mission to pass Illinois Senate Bill 3395 that would limit out-of-pocket costs for drugs – making vital medications affordable for those who need them.
Please visit the website – www.capthecopay.org – to learn more about the issue, join the coalition, and urge your Illinois Senator to support SB3395 to cap the co-pay
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Register to run with Team ALF at the Bank of America Chicago Marathon! Our tight-knit team of participants, coaches, and staff will lead you across the finish line with coaching, training and tools for success. To register or for more information visit liverfoundation.org/2014ChicagoMarathon today!
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Today I choose to learn I believe I am smart and strong and my future is bright and full of promise I will listen, I will follow directions, I will respect the right of others I will honor myself and my parents by being respectful, responsible, honest and safe.
Our school was named after Thomas John Claggett (1743-1816). He was the first bishop of the Episcopal Church in the United States of America to be consecrated on American soil and the first bishop of the Episcopal Diocese of Maryland.Our school history...How to reach our school
Claggett Elementary School is a safe community of learners that utilizes
teamwork, academic rigor, a strong work ethic and good customer service to provide
a quality educational program to students to enable them to become life-long
learners and good citizens.
2001 Addison Road, District Heights, MD 20747 • Phone 301-499-7050 • Fax 301-499-7060


text:
Let's Color! (Kumon First Step Workbooks)
From the Publisher
The First Steps series is designed for young children, aged 2 and up, who have never used a workbook before. The colorful and easy exercises in each First Steps workbook provide toddlers with the opportunity to become comfortable with the tools that are essential in every school scissors, glue, pencils and crayons. These workbooks also teach the motor skills and problem-solving abilities that are a childs First Steps towards success.
I work as a kindergarten teacher and spend a lot of time at the beginning of the year helping students develop their fine motor skills. One of the best ways to work on these skills is to engage children with coloring. When I saw the beginner Kumon books, I immediately wanted to try them with my 2 1/2 yr old son, and I'm so glad I made the purchase. He absolutely LOVES these books! They are very colorful, the illustrations are great, and the directions are very specific. For example, one his favorites was to use a blue crayon to draw rain coming from the clouds. The books gradually become more difficult, and now he has to fill in a white area with a specific color. I tell him that we are working on "school" and he loves it! Because of the reasonable price, I have also bought these for his friends for birthday gifts as well! :)
My 40 month old son was born with birth defects on his hands. The few fingers he has are very short and his muscles are a little weak. This book offers him a challenging and fun way to work on his fine motor skills. This workbook is well made with thick paper and a lot of colors. You cut off about 2/3 of the page and give it to your child and encourage him to color in the dot with a matching color on some of the pages. This is encouraging to small children so they don't have to fill in an entire page themselves. The last page is a write on wipe off page! The only drawback is that $5.95 for a small workbook is rather pricey to me.
I recently discovered the Kumon books and I am super pleased with them.I will be reviewing all those I have so it will help other parents get a better idea of what's inside. The LET'S COLOR book is very nice and is part of the Kumon First Steps series for ages 2 and up. I must say that this book isn't for the very young only. My son is 8, and is a very normal child in every way, yet like some children, has not been very quick to develop fine motor skills for writing, holding a pencil, cutting, etc. He has enjoyed all his Kumon books very much, and they are not babyish. LET'S COLOR is a very nice book for children who would be overwhelmed by a whole uncolored page being placed in front of them to "finish". I like that most of each page in LET'S COLOR is colored already and is very colorful; only a white circle, square, triangle (nice for teaching shapes along the way) is left blank for the child to color in. My son is very pleased with just a small bit of coloring to finish the picture. He especially loves when his colored pencil ( I recommend Prismacolors over crayons) matches almost exactly with the color of the object and when finished, you can't easily see where he did the coloring. Later pages have you color 2 or 3 parts of the picture, such as blue, green, and yellow circles on the beach ball, or 3 different colored balloons, or the yolk of the egg. Then the last few pages are having the child color the 2 flowers, the mane of the lion, the icing and candles on a birthday cake, or different parts of a clown. Even these pages with more white areas to color, are not overwhelming to a child, as the full picture is only about 8 inches square. My son enjoyed the first "scribble" pages, where you drew hair on a boy, spaghetti on a plate, sprinkles on the ice cream, water squrting out of the garden hose onto the children, etc. He has enjoyed coloring in this book as we have our read aloud time in the evening. Kumon uses high quality heavy paper, and the coloring pages are printed on one side only. I highly recommend it to any parent of young children, and would make a nice little gift with a new box of colored pencils or crayons. These are attractive when finished to give to grandma and grandpa to hang on their refrigerator. I really think you and your child will have fun with this book.
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Khronos Group Technology on Tour 2011
Nov 10, 2011
The Khronos Group is globetrotting in high gear to showcase Khronos technologies; including stops in Seattle, Daegu, Tokyo, Yokohama and Hong Kong. If you "just happen to be in the neighborhood," we cordially invite you to drop by for a visit to learn more about our APIs. A complete schedule is available online.
Category: General • Developers •
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Brahmaputra River
From Wikipedia, the free encyclopedia
The Brahmaputra is one of the main rivers in Asia. It has its origin in the Himalayas of Tibet. It flows through Tibet, India and Bangladesh. It is 2,900 km (1,800 mi) long. Massive flooding occurs when the ice melts in the Spring.
Finally it joins with the Ganges river and empties into the Bay of Bengal. This delta is the biggest delta in the world.


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Product Description
The Redline Standard Bungee Line is manufactured different than you have ever seen. Used by many of the top trainers in the dog sports, bungee lines offer many unique drive building methods for young dogs to seasoned adult dogs.
But these aren't your average Bungee lines! The Redline Bungee lines are unique and superior to many other bungee lines on the market. We have a special manufacturing process that takes the high quality 5/8" shock cord and inserts it inside tubular webbing. The webbing is then bunched up to allow the line to stretch out and knotted off with the shock cord. Nylon webbing color may vary.
No More Loops and Clumsy Hooks for You and Your Dog to Tangle Up In!
How far will your bungee cord stretch? The rule of thumb with bungee cord is that it stretches approximately 50% of it's dormant length. For example, a 7' bungee stretches to approximately 10.5' feet.
Available in 5/8 inch - 7 ft, 10 ft, 15 ft


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Next, you'll be asked to connect with Twitter. Rest assured, we will never send a tweet from your account
without your permission.
We will send you an email with an invite soon.
Great to see 231 followers of Green Voices Twitter list of freelancers I set up when @nytimesgreen blog folded. https://t.co/gM3ajQt482
Jim Witkin (125 @nytimesgreen posts ) added to Green Blog Voices list:
New Green Blog Voices Twitter list members: @nateschweber @DavidFerris
Twitter list of former @nytimesgreen journalists up to ~170 subscribers and growing:
via @greengotham: D3 Green Schools Group in #NYC has travelled green path many yrs, helps learning and planet.
RT @inhabitat: Facebook was give the thumbs up to build a sprawling new green-roofed, Frank Gehry-designed campus in Menlo Park
Seattle Building Not Just Green, but Practically Self-Sustaining Bullitt Center
See what's Trending Now for @Revkin
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Men's Hormones: Common Symptoms & Causes of the Imbalance in Men's Hormones
Men's hormones can become imbalanced too. Most people associate the imbalance of hormones with women, but many men also suffer from hormonal imbalance. This imbalance of men's hormones is known as andropause, basically male menopause, and can cause a variety of problems to many men who experience it.
Men's Hormones: What Are the Common Symptoms of Imbalance?
When men's hormones start to become significantly altered, many men will begin to experience a variety of symptoms. Not all men will experience the same symptoms to the same degree, and some men may only experience mild changes that do not affect their lifestyle too much. That being said, here is a list of some of the most common symptoms when there is an imbalance in men's hormones:
- Fatigue, decreased energy, and sluggishness
- A decline in muscle mass
- A decrease in sexual desire
- Erectile dysfunction
- Aging prematurely
- Reduction of hair and skin quality
- Irritability
Frequently Asked Questions
can a 25 year old man experience hormone imbalance?
I've been reading up on the symptoms of male hormone imbalance and I seem to exhibit a fair share of the symptoms. I am only 25 years old, and according to the articles it occurs in men who are closer to 40. Is it possible for me to have this imbalance at my age? If so, what types of treatment are available?
Can hormone treatment change some homosexuals to be straight?
I was just curious b/c it seems a lot of homosexual men are feminine and a lot of lesbians are masculine. For example, I see a lot of lesbians into sports and wear short hair and some homosexual men are into clothes fashions. In these cases, I was just curious if there are estrogen and testosterone imbalances and if hormone treatment would help.
u are talking about stereotypical homosexuals... we all don't fall under these categories. approx. 1 out of every 10 people are gay. we are not all fashion lovin' sports hormone imbalanced homos like u suggested.
Can a vitamin change a man's sexual orientation by correcting a hormone imbalance?
The following is provided for information purposes only. If you believe you have a medical condition requiring treatment, please consult a qualified physician.
Two years ago, my doctor ordered routine blood tests as a part of my yearly check-up, and the lab mistakenly measured 17-alpha hydroxyprogesterone (17-OHP). Although I am an adult male, my 17-OHP level is in the prepubertal range without evidence of a clinical disease.
17-OHP is considered to be a precursor of both testosterone (T) and cortisol. It is rarely, if ever, measured in men, and is primarily evaluated during pregnancy, or during the diagnostic workup for female infertility and congenital adrenal hyperplasia in children. If a man's T level is normal, 17-OHP is assumed to be normal. Although my testosterone (T) level is normal, 17-OHP is abnormal and my ratio of 17-OHP to T is 0.02. For men with normal testicular function the ratio is 0.24 +/- 0.08 (J Clin Endocrinol Metab. 1978 Nov;47(5):1144-7; Basal and human chorionic gonadotropin-stimulated 17 alpha-hydroxyprogesterone and testosterone levels in Klinefelter's syndrome).
Low 17-OHP levels are associated with combat stress, old age, steroid abuse; disorders such as Addison's disease, adrenal hypoplasia congenita, adrenal exhaustion, hypogonadism; and various intersex disorders such 17-beta hydroxysteroid dehydrogenase deficiency and Klinefelter's syndrome, a genetic condition characterized by an XXY chromosome pattern.
Both T and 17-OHP dramatically increase in males before and after birth. During the first 1-2 months of life, these hormones surge to adult levels during a period know as the "mini puberty" of infancy. Research suggests that exposure to prenatal stress can disrupted the surge in these hormones during critical phases of brain development.
Studies show that exogenous T increases a man's sex drive without changing his sexual orientation. Although it is well established that T is necessary for the development of male secondary sex characteristics, low, high or normal T levels alone do not determine a man's sexual orientation.
Again, it is interesting to note that both T AND 17-OHP surge simultaneously during the prenatal, postnatal, and adolescent periods of male sexual development. This seems to suggest that T may work together with either 17-OHP or some other hormone for which 17-OHP is a precursor, perhaps epitestosterone (EpiT). Too much or too little T in the absence of corresponding levels 17-OHP or EpiT in the blood may result in a homosexual orientation. It is possible that an imbalance between 17-OHP and T or T and EpiT may distinguish homosexual from heterosexual men. Currently, EpiT is only measured in urine for the purpose of detect illicit anabolic steroid use by athletes.
I worked with my doctor for a year before finding that the vitamin that balances my hormones is pyridoxine or vitamin B6, often referred to as the "anti-stress vitamin." Although my vitamin B6 level is normal, B6 at 150-200 mg per day for one month normalizes my 17-OHP level, while raising the ratio of 17-OHP to T from a baseline of 0.02 to 0.17. However, after a month without therapy my levels return to baseline.
It is well established that steroid hormones, such as estrogen and testosterone, exert their effects in the body by binding to steroid hormone receptors in the nucleus of the cell and altering gene transcription. Interestingly, the bioactive form of vitamin B6, pyridoxal-5-phosphate (PLP) binds to steroid receptors in a manner that inhibits the binding of steroid hormones, thus decreasing their effects. Consequently, increased binding of PLP to steroid receptors for estrogen, progesterone, testosterone, and other steroid hormones may explain why mega doses vitamin B6 correct my hormone imbalance.
I encourage anyone who believes there is a biological basis for his same-sex attraction to have his T, progesterone and 17-OHP levels measured. If you are unable to find a doctor to do so, or privacy is an issue, order the tests yourself through a direct access laboratory such as EconoLabs or Health Tests Direct.
My doctor always obtained both baseline and post-therapy early morning (8:00 AM), fasting blood samples. Recent vitamin, mineral, and prescription drug intake may compromise the accuracy of results. I eliminated them from my diet for at least two weeks prior to any blood test.
The Postnatal Gonadotropin and Sex Steroid Surge—Insights from the Androgen Insensitivity Syndrome The Journal of Clinical Endocrinology & Metabolism Vol. 87, No. 1 24-28
To date, there are no published, peer-reviewed studies of 17-OHP levels or 17-OHP to T ratios in homosexual males.
Homosexuality is not a disease. Many heterosexuals also experience same-sex attraction. There are three questions here:
1) Does vitamin B6 influence hormone levels?
2) Do 17-OHP levels and/or 17-OHP to T ratios distinguish homosexual from heterosexual males?
3) If such a difference exists, does vitamin B6 influence hormone levels and/or brain regions associated with sexual orientation?
There are no published studies on the effect of vitamins on sexual orientation.
Gays don't need to be "fixed."
And this doesn't belong in R&S.


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We never stop improving and that's why we're successful. See how we're improving facilities, programs, patient safety and patient satisfaction.
We're the most recognized community hospital in the state and it's our people who make us great. See hospital and staff awards.
Winchester Hospital was the first community hospital in the state to achieve Magnet designation, recognition for nursing excellence. Learn why.
Our tremendous staff gives back to our community by coordinating free health screenings, educational programs, and food drives. Learn more.
A leading indicator of our success is the feedback we get from our patients. See what they're saying about their experiences.
Gingivitis is a mild, often reversible form of gum disease. If left untreated, gingivitis can progress to a serious condition called periodontitis.
A substance that forms on teeth called plaque causes gingivitis. Plaque is a sticky material, composed of bacteria, mucus, food, and other substances. It hardens to form tartar or calculus. When plaque is left on the teeth for an extended period of time, it can lead to gingivitis. Toxins produced by bacteria in dental plaque irritate the gum tissue and cause infection, inflammation, and pain.
Factors that increase your risk of gingivitis include:
Gingivitis is often painless with symptoms developing when it becomes worse.
Symptoms may include:
The dentist will examine your teeth and gums, assessing them for swelling and areas where the tissue is pulling away from the teeth, forming a pocket. Early diagnosis of the problem enables prompt treatment and the possibility of reversing the condition. It is important to see your dentist every six months for a cleaning because gingivitis may have no symptoms in the early stages.
Gingivitis therapy aims to remove the irritating plaque and prevent its return.
Treatment includes:
Thoroughly brush and floss your teeth with a fluoride toothpaste. Use a soft-bristled toothbrush or a powered toothbrush held at a 45-degree angle to the line where your teeth and gums meet. Replace the brush or powered toothbrush bristles when the bristles become bent, frayed, or every 3-4 months. Move the brush in small circular movements along the gumline and chewing surfaces of your teeth.
Brushing removes bacteria from the teeth, but the brush cannot reach everywhere. Flossing helps get rid of food and bacteria between teeth. Hold the floss tight. Gently bring it down between the teeth. Do not pop the floss against the gum. Curve the floss around the tooth and rub up and down. Adjust the floss, so you use a fresh section for each tooth, including the back side of the last tooth, left and right, upper and lower.
The dentist may recommend additional self-care treatments, such as massaging the gums with a rubber tip. Rinses to fight bacteria and plaque build-up may help some patients.
Dental health professionals check for gingivitis and remove plaque that has built up on teeth. A visit every six months is usually considered adequate. Patients with gingivitis may need more frequent cleanings. If the disease progresses and plaque builds up below the gum line, the area must be scraped off and smoothed with dental tools. Otherwise, accumulated plaque and tartar buildup make it easier for bacteria to grow.
If an area has progressed to periodontal disease, surgery or medication may be required. Treating an underlying medical problem may improve the health of your gums.
In patients with recurring or persistent gingivitis, the dentist will evaluate whether some other condition may be contributing to the gum disease.
Strategies to prevent gingivitis include:
American Academy of Periodontologyhttp://www.perio.org
American Dental Associationhttp://www.ada.org
Canadian Dental Associationhttp://www.cda-adc.ca
Canadian Dental Hygienists Associationhttp://www.cdha.ca
Academy of General Dentistry website. Available at:
http://www.agd.org/support/articles/?ArtID=1250. Updated February 2007. Accessed July 27, 2011.
American Academy of Periodontology website. Available at:
Updated June 2010. Accessed July 27, 2011.
American Dental Association website. Available at:
Gingivitis. Mayo Clinic website. Available at:
http://www.mayoclinic.com/health/gingivitis/DS00363. Updated November 2010. Accessed July 27, 2011.
Taking care of your gums.
patient page.
4/7/2014 DynaMed's Systematic Literature Surveillance. http://www.ebscohost.com/dynamed: Weyant RJ, Tracy SL, et al. Topical fluoride for caries prevention: Executive summary of the updated clinical recommendations and supporting systematic review.
J Am Dent Assoc. 2013;144(11):1279-1291.
7/15/2014 DynaMed's Systematic Literature Surveillance
http://www.ebscohost.com/dynamed: Yaacob M, Worthington HV, et al. Powered versus manual toothbrushing for oral health. Cochrane Database Syst Rev. 2014 Jun 17;6.
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The tulips are pushing up from the hardened earth and there are flickering buds on the trees. After a long, chilly winter, spring is finally upon us. But just when everything begins to bloom in a rainbow color, we're invaded by the incessant scream of leaf blowers.
Studies have concluded that the sound spectrum of the gasoline-powered leaf blower contains high intensity and high frequency noise, which can have negative health impacts including noise-induced hearing loss.
Noise-induced stimulation of the nervous system can result in high blood pressure and cardiovascular disease. Noise has an adverse impact on sleep, communication and effects of performance and behavior. The unhealthful noise is only part of the negative impact of leaf blowers; they're a significant factor in creating air pollution.
The major pollutants from a two-stroke engine are oil-based particulates, a mixture of hydrocarbons, and carbon monoxide. When landscapers blow our yards they push dust, fecal matter, pesticides, fungi, chemicals, fertilizers, spores, and street dirt, which consists of lead and organic and elemental carbon into the very air our children and we breathe.
Often, operators blow dust and debris into the streets, leaving the dust to be re-suspended by passing vehicles. Some landscapers wear protective masks over their faces and headsets to protect their ears. But what about the rest of us? All we can do is stay in our homes or flee until the noise passes.
What are the options? Approximately 20 California cities have banned leaf blowers. We should consider doing the same. At the very least the village, the county and the State should mandate that two-cycle engines be banned and quieter models be introduced.
High intensity noise levels can be significantly reduced with newer machines and some landscapers are now using them. There is also the electric option, which is quieter still. Walk around and note the difference.
Ticket landscapers who blow debris into the street. The Village has an ordinance preventing people from pushing plowed snow back into the street. Yard debris should also be a violation. The bottom line is that we have an environmental issue and we have a health issue with leaf blowers.
Do we sit by and ignore it or do we become proactive and try and improve our quality of life? Let the trustees know how you feel. http://www.ci.rockville-centre.ny.us/


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EEC255 - Robotic Systems
3 units - Winter Quarter, Alternate Years
Lecture: 3 hours
Prerequisite: None
Grading: Letter, based on homework, class projects and exams as determined by instructor.
Catalog Description:
Introduction to robotic systems. Mechanical manipulators, Kinematics, manipulator positioning and path planning. Dynamics of manipulators. Robot motion programming and control algorithm design.
Expanded Course Description:
- Introduction to Robotics
- Definition of robotics
- Role of robotics in automation and manufacturing
- Classification of robot manipulators and robotic systems
- Robot Arm Kinematics
- Rigid motions and homogeneous transformation
- Forward kinematics and Denavit-Hartenberg representation
- Inverse kinematics
- Algebraic method
- Geometric method
- Motion Kinematics
- Jacobian
- Singularities
- Inverse velocity and acceleration problems
- Numerical method for inverse kinematics solution
- Manipulator Dynamics
- Lagrange-Euler formulation
- Kinematic and potential energy
- Equations of motion
- Moving coordinate system
- Newton-Euler formulation
- Trajectory Planning
- Polynomial paths and cubic segments
- Linear segments with parabolic blends
- Coordinated Cartesian space motion planning
- Robot Manipulator Control
- Review of PID control methods and disturbance rejection
- Actuator dynamics and independent joint control
- Computed torque method for robot manipulator joint space control
- Cartesian space control problems
Text: Robotics: Control Sensing, Vision, and Intelligence, K. S. Fu, R. C. Gonzales, and C. S. G. Lee, McGraw-Hill, 1987.
Engineering Design Statement:
Much of this course is devoted to the analysis, modeling, and design of mechanical manipulator kinematics, dynamics, and motion control. Because of the fact that manipulator models are highly nonlinear and complex, model selection, analysis techniques and assumptions made are very important aspects of the design process. Students are shown how to recognize certain factors and assess their impact on computational feasibility and system performance during the design process. The course includes individual projects which require computer simulations and laboratory experimentation to verify the validity of the designs.
ABET Category Content:
Engineering Science: 1 unit
Engineering Design: 2 units
Instructor: Gundes
Last revised: 2/06


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County Administrator, the Board of Supervisors, the County Auditor, the Treasury Oversight CASH IN VAULT : $134,012 : CASH IN BANK : $27,268,637 : Purchase Date Coupon Rate Trading Yield Current Par / Shares Current Book / Shares : … View Doc
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"Critical game code" means software that is used to determine game outcome, "Scan" means to attempt to verify a gaming voucher or coupon in a gaming voucher system by utilizing a device that can read its bar code, shall file with the Department of the Treasury, … Access Content
Quaterly Report And Certification Of The County Treasurer For …
County Administrator, the Board of Supervisors, the County Auditor, the Treasury Oversight Purchase Date Coupon Rate Trading Yield Current Par / Current Book / Shares : Shares : TREASURY NOTES : CASH IN VAULT 0.01% 99,407.59 99,407.59 … View Document
SUBCHAPTER 1 – The Official Web Site For The State Of New Jersey
19:45-1.46 Procedure for control of coupon redemption and other. voucher or coupon in a gaming voucher system or coupon acceptance system by utilizing a device that can read its bar code, "Vault cashier" is defined in N.J.A.C. 19:45-1.12. … Read More
Original promissory notes and other legal documents should be stored in a fireproof vault or another secure enclosure with limited access. including weighted average maturity and weighted average coupon, (City, State, Zip Code) FRB Telephone: (888) … Access Full Source
PC & Internet Monitoring Software Government
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INTERNAL REVENUE CODE . APPROVED FEBRUARY 10, 1939 . UNITED STATES . with the assistance of the Department of the Treasury and the Department of Justice. The bill embodying that codification, H. R. 2762, was introduced on January 18, 1939, … Doc Viewer
Association Of Public Treasurers Of The United States And Canada
Authority to manage the (entity's) investment program is derived from the following: (e.g., trading resolutions, code rendered by banks for a fee whereby securities and valuable of all types and descriptions are held in the banks vault Long term coupon-bearing U.S. Treasury … Fetch This Document
DEPARTMENT OF TREASURY. MICHIGAN GAMING CONTROL BOARD. Main bank vault or vaults. (D) Any other structure that houses tokens, chips, or other . accordance with title 31 of the United States Code, 31 U.S.C. § 5311 et . … Fetch Here
… Access Document – Financial Management,4th Edition By Suk Kim
Annual coupon interest = Coupon interest rate x par value of $1000 = .09 x $1000 = 90. Since the The treasury has raised money on an irregular basis through the sale of "cash management" bills since 1974. T 14. … Fetch Here
Funds from the Treasury and foreign local currency bank accounts. 4 FAH-2 H-212 USE OF CHECKS location code [ALC] symbol) disclosed by the verification are reported . UNCLASSIFIED (U) All check stock is stored in a vault. … Retrieve Doc
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Service code reference table lb programming coupon collections corr banks vault services jpmorgan insight treasury workstation supplier/payer payment channel banking center services government services enterprise content management … Fetch This Document
DEPARTMENT OF TREASURY – West Virginia Lottery
Authority – W. Va. Code – §29-22C-4(b)(5) and SB 417 – W.Va. Code §64-7-3. 1.3. 2.44.h.3 Main bank vault or vaults; and . §179-8-77. Coupon accounting procedures and distribution program. … Get Content Here
I. SCOPE AND OBJECTIVES – City Of Portland, Oregon
Which include but are not limited to the City's Code of Ethics. Agency Discount Notes or Coupon securities only. Maximum maturity – Securities held in vault at the City's Treasury . … Access Full Source
A Vault Into History..5 Flow of State Money Board of Treasury Investments.. 18 WV Retirement Plus or they may mail the payments with a payment coupon for the Treasurer's Office to … Get Content Here
… View Document – Southern Utah University – Cedar City, Utah
Use the code letters below to indicate for each balance sheet item the usual classification in which it is reported on the balance sheet. U.S. Government treasury bill that will mature in . 180 days from date of purchase 5,000. … Read More


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VATICAN CITY, Tuesday, June 24, 2014
Holy Howzzat! Mostly Indian Vatican XI to tour England
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Ninjas attack
Clearly demarcated as blatant self-promotion: I'm happy to announce that an effort I've been working on for about 3 years in semi-stealth mode is now live. After doing big data work for the spooks in the government and running a team of social and computer scientists, a few of us spun out a commercial venture I dubbed Ninja Metrics (www.ninjametrics.com).* Much of this comes from constantly asking game companies for data, then getting smart people to do cool things with it. Our team has now published 80 papers on game data, which is kind of ridiculous. It was time to put that power into an engine so we don't have to work quite so hard.
Among other things, we've figured out how to automate predictive analytics. WTH is that, you ask?Our system will automatically take in data and spit out all of the stats and metrics one would expect. DAU, ARPU, yadda yadda. That was the easy bit. The cool part is that the system actually builds models on the fly. As in it takes the raw data, cleans it, then can tell you the predictive likelihood of a player to do something next week. Spend, quit, convert, cheat, etc. It's running about 80-90% accurate.
The coolest thing we do relates to players interacting with each other but I'll save that for a second post.
If you're interested in the science of games and data analysis, I've started a blog on the topic, which can be found here. Please feel free to subscribe or link to it (this makes my marketing guy happy).
And if you'd like me to tackle anything data-related here at TN, fire away and I'll dig in. After hiding underground for three years, I'm about ready to be public again. The 10-year anniversary makes me nostalgic for the days when we were stomping around arguing that games were important.
Also, and this is a long-term goal, it's my hope that by getting a load of game data I'll be able to anonymize it at some point and open it to the broader research community. I have seen what a great group can do with just a little and am excited to see more.
*Why? I like ninjas. Isn't that a good enough reason?
Comments on Ninjas attack:
Congrats Dmitri! It sounds awesome already, and I've the feeling it's the start of an evolution in sophisticated game design... Anyway, looking forward to learning more as you move forward.
Posted Sep 25, 2013 1:44:59 PM | link
The link to Ninja Metrics is not working. Looks like it is somehow relative when it should be absolute. Hope this helps!
Posted Sep 25, 2013 7:13:40 PM | link
Weird! Thanks for catching, fixed. At the risk of the obvious, it's www.ninjametrics.com.
Posted Sep 25, 2013 8:03:38 PM | link
Does Ninja Metrics work with any Learning Management System?
Posted Sep 26, 2013 4:39:02 PM | link
We haven't, but as we look outside of gaming we're thinking about how our social value system could help in other spaces. The keys are that the experience is social, data can be collected via API or from an existing database, and that we can somehow build social graphs of the end-users. In gaming, that's easy since they play, talk and do joint sessions. In other verticals it often means we need to piggyback on to an existing graph like Facebook, which in turn necessitates a social sign in.
Feel free to ping me off-list as well as raise issues/questions/challenges here.
Posted Sep 26, 2013 6:12:57 PM | link
Congrats, Dmitri!
Looks awesome.
Posted Oct 3, 2013 9:36:24 PM | link
Congrats, Dmitri!
Looks awesome.
Posted Oct 3, 2013 9:36:25 PM | link


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Originally posted 04/20/2012 10:50AM
Some of the biggest names in music are honoring one of the biggest legends.
After Levon Helm, the drummer for The Band, died Thursday at 71, Sheryl Crow took to Twitter to express her condolences.
"My heart [is] heavy with sad news of Levon Helm's passing," she wrote. "My thoughts and prayers are with Levon's family."
Also Tweeting about the late Helm, who had cancer: Maroon 5 frontman and The Voice coach Adam Levine.
Originally posted 05/07/2011 10:05AM
Sheryl Crow is dating a new guy – and he's someone she's known for a while.
The singer is in a relationship with musician Doyle Bramhall II, who currently plays in her touring band and co-produced her last album, 100 Miles from Memphis, a source tells PEOPLE.
"They've known each other for a really long time but it only turned romantic recently," the source says. "She's really happy. He's a really great guy."
Originally posted 11/29/2010 07:15AM
When Brad Paisley was a little boy, the best Christmas gifts he ever received included a tent that he pitched in his living room that "stayed up until New Year's," a Battlestar Galactica model kit and most special of all, a guitar his grandfather gave him when he was eight. "Nothing changed my life like that Christmas gift," he says.
Those memories are just some of the holiday stories shared by the country stars appearing on CMA Country Christmas, a TV special airing Monday night (9:30 p.m. ET) on ABC.
Between performances from Kellie Pickler ("Santa Baby), LeAnn Rimes ("Rockin' Around the Christmas Tree"), Sheryl Crow and Brad Paisley (singing a duet of "Run, Run Rudolph") and Darius Rucker (who will sing a new holiday tune), country music's biggest names will share new and old family traditions:
Originally posted 11/22/2010 12:00PM
Originally posted 10/18/2010 08:00AM
After half a century in the music business, Loretta Lynn is to be honored at next month's CMA Awards, when Miranda Lambert and Sheryl Crow deliver a special performance of Lynn's signature song, "Coal Miner's Daughter."
Lambert and Crow also sang a version of the 1970 hit with Lynn on a tribute album due out Nov. 9. The two were among an eclectic group of artists chosen for the album by Lynn herself – who hand-wrote personal notes to each asking them to participate – among them, Carrie Underwood, Faith Hill, Kid Rock, the White Stripes, Paramore, Alan Jackson and Steve Earle.
Originally posted 07/20/2010 12:35PM
Originally posted 06/04/2010 11:15AM
Sheryl Crow is a mom again!
"I have some exciting news to share with you guys," the musician announced on her official Web site Friday, "Wyatt has a new little brother!"
Crow, 48, adopted now 3-year-old Wyatt in 2007, and also tells fans, "Levi James was born April 30."
Originally posted 02/18/2010 06:00AM
Back from their Mexican getaway with Jennifer Aniston, gal pals Courteney Cox Arquette and Sheryl Crow caught up over lunch at organic eatery Akasha in Culver City, Calif. Arriving in jeans and T-shirts, the breezy duo ordered salads and fresh-squeezed juices, and spent an hour chatting and giggling before leaving on foot.
Originally posted 02/18/2010 06:00AM
Back from their Mexican getaway with Jennifer Aniston, gal pals Courteney Cox Arquette and Sheryl Crow caught up over lunch at organic eatery Akasha in Culver City, Calif. Arriving in jeans and T-shirts, the breezy duo ordered salads and fresh-squeezed juices, and spent an hour chatting and giggling before leaving on foot.
Originally posted 01/31/2010 12:45PM
No one can bring out the stars quite like Clive Davis! The music mogul's Pre-Grammy Gala & Salute to Industry Icons (this year honoring Universal Music Group Chairman and CEO Doug Morris) is an annual tradition and one of the biggest parties of the year. And with a bevy of stars – including Jay-Z, Rihanna, Katy Perry, Russell Brand, Taylor Swift, Ne-Yo, Sheryl Crow, Adam Lambert and Barbra Streisand – in attendance, Saturday night's bash at the Beverly Hilton Hotel was no exception.
"It's one of those parties that you have to come to," Ciara, in head-to-toe Givenchy, told PEOPLE on her way in. "I'm excited to see everybody! It's cool to see people that you know, people that you don't know. It's always great to see Clive, and I'm just looking forward to having a great time."
Fergie, in a Zuhair Murad party dress, breezed down the red carpet in a hurry, stopping only to have a happy chat with Nick Jonas. But the singer had a good reason to rush: The Black Eyed Peas opened the show with Slash singing the classic Guns n' Rose's tune "Sweet Child O' Mine."
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Note: The well formed interhemisphere fissure and hypogenesis of corpus callosum was noted. No septum pellucidum was visualized. The optic chasm was small in size but the pituitary stalk was preserved. The stellar fossa was filling with CSF and the pituitary gland was remarkable decreased in height. The temporal born was dilated on both sides. The hippocampal and amygdala volume were decreased on left side. A lipoma was found in the quadrigeminal.
To the Editor: Septo-optic dysplasia is a syndrome of congenital midline malformations of the forebrain, which is characterized by hypoplasia or absence of the septum pellucidum, hypoplasia or dysplasia of the optic nerves, and pituitary-hypothalamic dysfunction.1,2 Cases of septo-optic dysplasia with other midline structure abnormalities (corpus callosum, fornix), hemispheric lesions (schizencephalic clefts), or pathologic formation of the hippocampus have been reported.1 Clinical presentations of septo-optic dysplasia include variable ophthalmologic symptoms and endocrine defects. Neurologic impairment and mental retardation are not uncommon. To our knowledge, no psychiatric disorder has ever been reported in septo-optic dysplasia patients. We present a case of major depression with a finding of septo-optic dysplasia by magnetic resonance imaging (MRI) scan as well as treatment response to electroconvulsive therapy (ECT).
A 41-year-old man was born without perinatal injury. He had experienced persistent and obvious ataxia since he began to walk and suffered from insomnia, lack of energy, dysphoric mood, social withdrawal, and low-self-esteem since his early teenage years. He did not look for psychiatric help until he was 30 years old. He received at least three kinds of antidepressants with sufficient dosage and duration, 10 sessions of psychotherapy, as well as a single month-long hospitalization, but with limited effect. He had received a third ventriculostomy for hydrocephalus at the age of 39. Postoperative course was unremarkable despite the persistence of ataxia. He was therefore rehospitalized for ECT treatment. On admission, a mental status examination revealed a depressed man with an intact outer appearance. He experienced sleep disturbances and frequent suicidal ideations. Endocrine tests were within normal ranges. MRI of the head revealed hypogenesis of the corpus callosum, agenesis of the septum pellucidum, decreased volume of hippocampus and amygdala, and increased ventricle volume (Figure 1). Hydrocephalus was not likely, based on negative findings of both CSF jet flow study and neurologic examination. No specific abnormality was found in his eyes. The patient received ECT after giving an informed consent. The MECTA SpECTrum 5000Q delivered the stimulus in a bilateral type. Eight successful ECT treatments were performed with a total motor seizure time of 346 sec. Delirium developed transiently after ECT in the first few sessions but was alleviated after the anesthetic agent pentothol was switched to propofol. His memory was mildly impaired but it gradually subsided in time. Mood status was assessed using the Hamilton Depression Rating Scale (HAM-D) at the pre- and 3-month post-ECT (scores of 22 and 23, respectively) did not show responsiveness to ECT. The only improvement was that his suicidal ideation was eliminated when he was discharged.
We present a case of refractory depression with septo-optic dysplasia who experienced transient delirium and had limited improvement of depressive symptoms in response to ECT. Unlike other septo-optic dysplasia cases, this patient only had depression and ataxia without obvious optic nerve lesions or pituitary-hypothalamic dysfunction. Several studies have found smaller hippocampal volumes in patients with major depression.3,4 We suggest that clinicians should incorporate a differential diagnosis of septo-optic dysplasia in refractory depression patients who were associated with neurological symptoms at early development.
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Radical Womanhood
- Thursday, January 15, 2009
There were little skirmishes along the way. Sometime in college, as I recall, my growing feminism ruined Thanksgiving. During dinner, my uncle, a no-nonsense Naval Academy graduate, made some comment— now long forgotten and probably more benign than I recognized—to which I took great offense. I began a tirade about rape, patriarchy, the oppression of "womyn," and the suffocating roles of wives and mothers. (None of which, with the exception of patriarchy, had I personally experienced.) Any refutation of my sweeping condemnations was met with increased volume and passion on my part. I had lived a mere two decades, but in my opinion I possessed the wisdom of the ages.
Then there was the time I stunned my father with the announcement that if I were ever to marry, I wasn't going to change my last name. At the time, I thought it was a repressive and unnecessary tradition, and I didn't see any reason to change my identity just because I would obtain a husband. I honestly thought my father would champion my idea because he was the father of three daughters and if we all changed our names, the family name would die with him.
But he didn't seem pleased, which genuinely surprised me. In hindsight I honestly don't know if it was the information or my attitude that provoked his reaction.
I learned a lot of theory in women's studies classes, but surprisingly, I didn't learn a lot of actual history. We learned about the women's liberation movement of the 1960s and 1970s, but not anything earlier. I don't recall studying anything written prior to Betty Friedan's influential book from the 1960s, The Feminine Mystique … which is to say, nothing earlier than my own lifetime. It would be years before I learned about the suffrage movement that preceded modern feminism, the differing impacts of the Reformation and Enlightenment on gender roles, and, finally, what the Bible says about men and women.
Feminism taught me that men were the problem, but in the end feminist politics left me yawning. While I had no problem agreeing that men in general were the problem, individual and specific men seemed far more agreeable and even attractive to me. After awhile, the strident victimhood of feminism lost its appeal. Though one of my fellow graduates went to work for feminist political action groups—the National Organization for Women (NOW) and then the Feminist Majority—I took my journalism diploma and my women's studies certificate and pursued a career in media.
It wasn't long before my definition and practice of feminism became as generic as that of the next woman clutching Cosmopolitan magazine. Social constructs and gender theories were dim memories. I was left with androgynous "dress for success" fashion, a hyper perception of sexual harassment and discrimination on the job, and a caricature of masculine sexuality as a model of freedom for both sexes. Aggression at work and on dinner dates was the legacy of my education.
When I was twenty-nine, I surveyed my life and perceived the emptiness of it. A relentless self-focus hadn't produced much happiness.
The Fractured Feminine Psyche
During this time, a friend of mine lent me a book, telling me how helpful it was for "reclaiming a whole feminine psyche." The book's premise was that women could be restored by studying the weaknesses and strengths of the goddesses from Greek mythology and by seeking to reconcile these archetypes into one complete woman. I took the test in the book and found out that I tested very high as Athena, the warrior goddess who sprung fully formed from the head of Zeus. This is the section of the summary that I noted in my journal at the time:
"It's easy to spot Athena in the modern world. She's out there in every sense of the word. Editing magazines, running women's studies departments in colleges, hosting talk shows, making fact-finding tours to Nicaragua, producing films, challenging the local legislature.
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Negative Approach
|Negative Approach
Negative Approach at St. Andrews Hall on July 31, 2010
|Background information
|Detroit, Michigan, United States
|Hardcore punk
|Years active
|1981–1984, 2006–present
|Touch and Go, Reptilian , Taang!
|John Brannon
Chris "Opie" Moore
Harold Richardson
Ron Sakowski
|Past members
|Pete Zelewski
Rob McCulloch
Graham McCulloch
Kelly Dermody
Mike McCabe
Negative Approach is an American hardcore punk band, formed in Detroit, Michigan in 1981. The band is considered among the pioneers of hardcore punk, particularly in the Midwest region.[1] Like most hardcore bands, Negative Approach was little known in its day outside of its hometown. It is now idolized in the Detroit rock underground and the punk subculture, considered to be one of the elite bands of the "old school" era, and continues to be influential.[2] Negative Approach initially broke up in 1984 with singer John Brannon moving on to the Laughing Hyenas, and later Easy Action, but the band has reformed as of 2006 and continues to tour sporadically.[3]
- 1 Biography
- 2 Influences and style
- 3 Band members
- 4 Discography
- 5 References
- 6 External links
Main career (1981-1983)[edit]
Negative Approach was formed in August 1981 in Detroit, Michigan by John Brannon and Pete Zelewski, supposedly after seeing a Black Flag/Necros show. The first NA lineup consisted of Brannon on vocals, Rob McCulloch on guitar, Pete Zelewski on bass and Zuheir on drums. Not long after, Zelewski left the band to form the Allied and was replaced by Rob McCulloch's brother Graham.[1] Zuheir Fakhoury was later replaced by Chris "Opie" Moore. The lineup of Brannon/McCulloch/McCulloch/Moore would remain unchanged until NA disbanded.
NA's first gig was in the basement of Necros drummer Todd Swalla's mother's home. Soon after, they recorded a demo, and followed that up with an appearance on the Process of Elimination compilation 7" EP, released on Meatmen frontman Tesco Vee's fledgling Touch & Go label, named after his fanzine of the same name. The comp also featured the Necros and the Meatmen, among others. NA, the Necros and the Meatmen then embarked on the Process of Elimination tour. Though this "tour" consisted of a mere three shows (Boston, New York City and Washington, DC), it is cited as being a key event in the early spread of hardcore.
The first proper Negative Approach studio release came in 1982 with their self-titled 7" EP, also on Touch & Go. It contained "Can't Tell No One," "Ready To Fight" and "Nothing," which is considered by many to be the quintessential NA song.[1]
The following year saw the release of the Tied Down LP, also venerated as a hardcore classic.[1]
The classic line-up fell apart in 1983. Rob McCulloch claims that the band had grown weary of the group's reputation for writing negative lyrics but that John Brannon was not comfortable writing differently.[4] Also, Rob has stated that John's involvement with Larissa Stolarchuk from L-Seven was another source of tension for the group.[5] The band re-grouped long enough to record the Tied Down LP, then split for good.[5]
Afterwards, Brannon assembled a new line-up with members Kelly Dermody (guitar), Dave (bass) and Mike McCabe (drums). This version of Negative Approach played a series of live shows throughout 1984 which featured some new songs, such as "Obsession," "Tunnel Vision," "Kiss Me Kill Me" and a cover of "I Got A Right" by the Stooges. This line-up can be heard on the Live at the Newtown Theater bootleg 7" and some live tracks recorded at Boston's Paradise club that appear on the Total Recall discography CD. The new line-up of the band split during the first week of their tour in support of Tied Down, playing their last show in Memphis.[5]
Post-break up (1983-2006)[edit]
John Brannon went on to front the punk blues band Laughing Hyenas with his girlfriend Larissa Stolarchuk (then calling herself "Larissa Strickland") from L-Seven,[6] and currently sings for Easy Action. In 2008 John Brannon recorded vocals for 2 songs on Vitamin X's album Full Scale Assault, recorded by Steve Albini.
Opie Moore moved out from behind the drums to front '80s/'90s alt-rock act Crossed Wire along with Rob McCulloch. After Crossed Wire, Rob McCulloch attended college and has not pursued a career in music, although he maintains a home recording studio. Currently, Moore enjoys a respected solo career as an edgy roots-oriented singer and songwriter. His current band, Moore & Sons on the UK's Triumphant Sounds/Drawing Room label, features Lambchop member Dennis Cronin.
Graham McCulloch moved to Washington, DC and joined the Meatmen before forming Earth 18 with John "Bubba" Dupree (formerly of Void). Earth 18 released several albums and toured the US, opening for Nitzer Ebb. After Earth 18 disbanded Graham played for several years in Mother May I.
Reunion (2006-present)[edit]
It was announced in May 2006 that Brannon and Moore would play a Negative Approach reunion show, of sorts, for Touch & Go's 25th Anniversary show on September 9, 2006,[7] as well as two later shows in the UK - London on December 7 and at All Tomorrow's Parties on December 10. Despite repeated efforts by Rob and Graham McCulloch to be a part of the reunion and have the classic NA lineup play, John refused. It was instead announced that Harold Richardson (of Brannon's current band Easy Action) and Ron Sakowski (formerly of Easy Action, Laughing Hyenas, and Necros) would complete the lineup.
Negative Approach closed out the No Fun Fest in Brooklyn, New York on May 20, 2007. Thurston Moore played guitar on two songs at the start of their set.
Negative Approach did a brief reunion tour in the northeast United States in April 2008, performing in Brooklyn and Providence. They also played the wedding of Anal Cunt founder Seth Putnam. The band did a lengthier tour of Europe in June 2008, and later that year a concert in Los Angeles. In 2009, they played a string of shows in the US.
On July 31, 2010 Negative Approach played the Touch and Go Fanzine-The Book Release Party, at St. Andrew's Hall in Detroit, with Tesco Vee's Hate Police, Sorcen, Violent Apathy, and Hellmouth. The show featured bands from the formative years of the Midwest hardcore scene and launched the release of the book, Why Be Something That Your Not, by Tony Rettman. The book shares the title with a Negative Approach song, and includes interviews with artists from the Detroit hardcore scene. The tour also featured the signing of the book, Touch and Go: The Complete Hardcore Punk Zine '79-'83 by Tesco Vee & Dave Stimson which was edited by Steve Miller.[8][9]
In 2010 Brannon discovered several unreleased Negative Approach recordings which contained the lost 1984 sessions of unreleased studio tracks. After meeting Curtis Casella of Taang! Records, Casella offered to release the recordings, which include "Friends Of No One", "Cargo Cult" "Kiss Me Kill Me", "Obsession", "Genocide" and a studio version of "I Got A Right". The tapes were brought to Jim Diamond to restore and preserve. Taang! released an album containing the recordings called "Nothing Will Stand In Our Way" in November 2011 around the time the band played the Fun Fun Fun Festival in Austin Texas with Anthony DeLuca sitting in on drums in place of Moore.
Influences and style[edit]
Negative Approach's musical style was based on Detroit proto-punk/rock & roll icons The Stooges.[3] Of The Stooges' guitarist Ron Asheton, John Brannon said, "So much of what NA stands for; our sound and lyrics were based on the music which he helped to create." NA were also influenced by high-octane British punk rock (especially Discharge) and Oi! music (Blitz, 4-Skins,Sham 69, etc.), although from the start their sound and demeanor were considerably more aggressive and brutal than that of their influences. NA's brand of hardcore was savage and nihilistic, exuding frustration, pessimism and rage. This was personified in the band's vocalist John Brannon, an intimidating and intense young man with a shaved head, piercing stare and belligerent attitude. His vocal style and stage presence set the standard for those that followed.[2]
Band members[edit]
- John Brannon - vocals (1981–1984, 2006–present)
- Chris "Opie" Moore - Drums (1981–1983, 2006–present)
- Harold Richardson - Guitar (2006–present)
- Ron Sakowski - Bass (2006–present)
- Pete Zelewski - Bass (1981)
- Zuheir - Drums (1981)
- Rob McCulloch - Guitar (1981–1983)
- Graham McCulloch - Bass (1981–1983)
Touring musicians[edit]
- Kelly Dermody - Guitar (1984)
- Dave - Bass (1984)
- Mike McCabe - Drums (1984)
- Anthony DeLuca - Drums (2012)
- Chuck Burns Drums (2013)
Studio albums[edit]
- Tied Down (1983, Touch & Go)
- Negative Approach (1982, 7", Touch & Go)
- Friends Of No One (2010, 7"/CD EP, Taang! Records) Recorded In 1984
- 1st Demo (5/81)
- Lost Cause Demo (8/81)
- EP Demo First Version (late '81/early '82)
- Tied Down Demo (6/83) [a.k.a. Rice City Demo]
Compilation albums[edit]
- Total Recall (1992, Touch & Go)
- Ready to Fight: Demos, Live and Unreleased 1981-83 (2005, Reptilian)
- Nothing Will Stand in Our Way (2011), Taang! Records
- Fair Warning, Vol. 1 (2006)
- Fair Warning, Vol. 2 (2007)
- Can't Tell No One (2008)
Other appearances[edit]
- "Lost Cause" on Process of Elimination (1981, 7" EP, Touch & Go)
- "Can't Tell No One" on Reagan Regime Review (Selfless) (1992, a compilation of live tracks, released with the last issue of Touch & Go fanzine)
- "Sick of Talk" on Sugar Daddy Live split series Volume 5 with Melvins, Necros, and Die Kreuzen
- "Borstal Breakout" on BASH 13 (2013, 10" split with Melvins, Mudhoney, Die Kreuzen, Gay Witch Abortion and Hepa-Titus
- ^ a b c d Kantor, Matthew Isaac (2008). "Negative Approach". Allmusic (Zvents).
- ^ a b Rettman, Tony (2008). "The Detroit hardcore scene". Swindle (issue 12).
- ^ a b JC, Sammy (August 27, 2006). "F Yeah Fest Preview: An Interview with John Brannon of Negative Approach". The Set List.
- ^ Arsehole, Stuart (2000). "Negative Approach Interview from Game of the Arseholes No. 4". KILL FROM THE HEART.
- ^ a b c Rettman, Tony (2007). "The Detroit hardcore scene". SWINDLE Magazine (Issue 12).
- ^ Christe, Ian; Ira Robbins (1995). "LAUGHING HYENAS". Trouser Press.
- ^ Hay, Edwina (September 12, 2006). "Touch & Go 25th Anniversary Block Party, Day Two". BrooklynVegan.
- ^ BBG (May 12, 2010). "Tesco Vee, Negative Approach & others playing Detroit hardcore book release shows & other dates". BrooklynVegan (a member of Spin Music).
- ^ Jackman, Michael (July 28, 2010). "Teenage wasteland: Detroit's first-wave hardcore finally gets its due". Detroit Metro Times.
External links[edit]
- Negative Approach on Myspace
- Negative Approach page on Kill From the Heart
- Negative Approach At Punk Island 2010
- Negative Approach on Punknews.org


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if I knew myself, I'd run away.
Catching Elephant is a theme by Andy Taylor
reblogging to say thanks to Amanda Palmer Photos for the reblog! :)
I had an amazing view of this from the balcony. Easily the best crowdsurf I've ever seen, embedded in the middle of just...
We were there and it was epic under the dress.


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- Funding Received
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- Most Recent Funding
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Company DetailsUpdate
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NASHVILLE, Tenn. (AP) — A post-mortem report says a pulmonary aneurysm killed the horse that won the Iroquois Steeplechase.
The preliminary necropsy obtained by The Tennessean (http://tnne.ws/K1Ytze) concluded that the horse Arcadius was killed after the pulmonary artery just above the heart ruptured a few minutes after the Nashville race ended Saturday.
The report said the rupture caused a massive hemorrhage and heart attack.
Pathologist Dr. Bruce McLaughlin of the state's Kord Animal Health Laboratory conducted the necropsy. He said in a statement that the 8-year-old gelding was otherwise in excellent health.
Information from: The Tennessean, http://www.tennessean.com


text: [ Ex-Manalapan Mayor Charged with Wire Fraud, Identity Theft By Tom Mongelli February 7, 2014 Former Manalapan Mayor Andrew Lucas appears in a federal court in Trenton today to answer accusations that he doctored IRS tax returns in order to buy Burke Farm in the township and gave false documents to investigators and a federal grand jury. Read More|Comment Category: Briefs, New Jersey News Tags: Andrew Lucas, Manalapan, Wire Fraud Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Pharmacological properties Vesicare 5 mg:
Vesicare in vitro studies and in vivo studies revealed that Solifenacin is a competitive specific antagonist of cholinergic receptors primarily M3 subtype. Solifenacin has a low affinity for other receptors and ion channels.
The therapeutic effect of the drug, which was studied in several double-blind, randomized, controlled clinical trials in men and women with overactive bladder syndrome, observed already in the 1st week of treatment and stabilized during the following 12 weeks of treatment. The maximum effect of the drug can be observed already after 4 weeks. The efficacy of long-term use remains.
After oral administration, maximum concentration of solifenacin plasma levels achieved in 3-8 hours time to reach maximum plasma concentration is independent of dose. The maximum concentration and AUC increased in proportion to dose in the range 5-40 mg. The absolute bioavailability of approximately 90%. Food intake has no effect on the maximum concentration and AUC. Volume of distribution of solifenacin after i / v administration of approximately 600 liters. Solifenacin is largely (about 98%) is bound to plasma proteins, mainly α1-acid glycoprotein.
Solifenacin is actively metabolized in the liver, primarily by cytochrome P450 3A4 (CYP 3A4). Systemic clearance of solifenacin is approximately 9.5 l / h, the final period of its half-life 45-68 hours after oral administration of the drug in blood plasma, except for solifenacin were identified by a pharmacologically active (4R-gidroksisolifenatsin) and three inactive metabolites (N-glucuronide , N-oxide and 4R-hydroxy-N-oxide solifenacin).
After a single injection of 10 mg of 14C-labeled solifenacin 26 days approximately 70% of the radiolabel determined in urine and 23% – in the feces. In the urine as unchanged active substance derived approximately 11% of the radiolabel, approximately 18% – in the form of N-oxide metabolite, 9% – metabolite 4R-hydroxy-N-oxide and 8% – 4R-hydroxy metabolite (active metabolite).
In the range of therapeutic doses of linear pharmacokinetics.
There is no need to adjust the dose depending on age. It is established that exposure to solifenacin (when taken in doses of 5 and 10 mg), expressed as AUC, was similar in healthy elderly (65-80 years) and in young and mature (younger than 55 years). The average rate of absorption, expressed as a time to reach peak concentration was slightly lower and the terminal half-life of approximately 20% longer in the elderly. These minor differences are not clinically significant. The pharmacokinetics of solifenacin does not depend on the patient's sex and race.
AUC and maximum concentration of solifenacin in patients with mild to moderate renal insufficiency significantly different from those in healthy subjects. In patients with severe renal impairment (creatinine clearance
INDICATIONS Vesicare 5 mg:
The Urge (mandatory), urinary incontinence, frequent urination and Urgent (imperative) urination characteristic of patients with overactive bladder syndrome.
Application: The recommended dose for adults – 5 1 mg once daily with or without food, drinking the liquid. If necessary, the dose may be increased to 10 mg 1 time per day.
CONTRAINDICATIONS Vesicare 5 mg:
Hypersensitivity to solifenacin, or other components of the drug, urinary retention, severe gastrointestinal diseases (including toxic megacolon), myasthenia gravis, angle-closure glaucoma, hemodialysis, severe hepatic, severe renal or hepatic failure of moderate severity and treatment, while a potent inhibitor of cytochrome CYP 3A4 (eg ketoconazole).
SIDE EFFECTS Vesicare 5 mg:
The use of Vesicare possible side effects associated with anticholinergic action solifenacin, which are usually weakly or moderately expressed and dose-related. The most frequent side effects – dry mouth. Dry mouth, usually mild, and only in rare cases requires the removal of the drug.
The incidence of adverse events classified as follows: very common (
Gastrointestinal: Frequent – nausea, indigestion, constipation, abdominal pain, infrequent – dryness of the pharynx, gastro-oesophageal reflux, rarely, in rare cases – obstruction of the colon, coprostasia.
CNS: rare – drowsiness, impaired taste.
From the senses: common – blurred vision (disturbance of accommodation), Uncommon: dry eyes.
Infections and infestations: not often – urinary tract infection.
General disorders: rarely – fatigue, lower extremity edema.
The respiratory system: Infrequent – dryness of nasal mucosa.
For the skin: Infrequent – dry skin.
From the urinary system: Infrequent – difficulty urinating, in rare cases – urinary retention.
PRECAUTIONS Vesicare 5 mg:
Before the start of drug treatment is necessary to establish the likelihood of other causes of frequent urination (kidney disease, heart failure or other). If you found a urinary tract infection, you should start appropriate antibiotic therapy.
The drug should be used with caution in patients with clinically significant obstruction of the opening of the bladder, obstructive diseases of the digestive tract, gastrointestinal motility disorders, severe renal (creatinine clearance
It should not be prescribed the drug to patients with congenital disorders of sensitivity to galactose, lactase deficiency or glucose-galactose malabsorption.
The effect of the drug already noted in the 1st week of treatment, but the maximum effect is achieved after 4 weeks of therapy.
Data on the use of the drug have no children.
Because of its ability, like other anticholinergics may cause a decrease in the rate of accommodation and psychomotor reactions, the question of the appropriateness of potentially hazardous activities need to be addressed only after evaluating the individual patient's response to the drug.
No clinical data on the use of solifenacin in pregnancy, but in experimental studies revealed no direct adverse effects on fertility, fetal development or during childbirth. Therefore caution should be exercised when using the drug in pregnant women.
No data on the excretion of solifenacin in breast milk, so use Vesicare during breast-feeding is not recommended.
INTERACTION Vesicare 5 mg:
concomitant use of other drugs with anticholinergic properties may have a more pronounced therapeutic effect, and to show more side effects. After stopping Vezikara to use other means to the anticholinergic effect should be kept approximately 1 week interval.
The therapeutic effect of solifenacin may be reduced by simultaneous administration of cholinergic receptor agonists. Solifenacin can reduce the effectiveness of stimulants motility gastrointestinal tract (metoclopramide, cisapride).
While receiving ketoconazole or other potent inhibitor of the enzyme CYP 3A4 (eg ritonavir, nelfinavir, itraconazole) Vesicare dose should be reduced to 5 mg. Simultaneous administration of solifenacin and the active enzyme CYP 3A4 inhibitor is contraindicated in patients with severe renal or moderate hepatic impairment.
Since Solifenacin is metabolised by the enzyme CYP 3A4, are possible pharmacokinetic interactions with other substrates of this enzyme (such as verapamil, diltiazem) and inducers of the enzyme CYP 3A4 (eg rifampicin, phenytoin, carbamazepine).
There was no pharmacokinetic interaction between solifenacin with combined oral contraceptives (ethinyl estradiol / levonorgestrel).
Vesicare not affect the pharmacokinetics of warfarin and digoxin.
Overdose Vesicare 5 mg:
The maximum dose used was 100 mg of the drug dose. It was noted side effects such as slight headache, moderate dry mouth, dizziness, drowsiness, blurred vision.
In case of overdose should be gastric lavage and activated charcoal to appoint. As with other anticholinergic drugs overdose, conduct the following activities: when expressed central effects (hallucinations, agitation) – physostigmine or carbachol, with cramps – benzodiazepines, with respiratory failure – mechanical ventilation, with urinary retention – catheterization of the bladder, with mydriasis – burial in pilocarpine eye or placing the patient in a darkened room, with tachycardia – β-adrenoceptor blockers. Particular attention should be given to patients at risk lengthening the Q-T interval on the ECG (with hypokalemia, bradycardia, concomitant use of drugs known to cause prolongation of the interval Q-T) and patients with heart disease (IHD, arrhythmia, congestive heart failure).


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