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Enrichr can now accept BED files as input for enrichment. Enrichr automatically converts the BED file into a gene list. The species supported are human and mouse. The maximum number of genes to produce from the bed file can be adjusted. If the gene list produced by the conversion has more genes than the maximum, Enrichr will take the best matching 500, 1000 or 2000 genes. The file must have the extension ".bed" and must be uploaded, not copy and pasted.
You can now view your input gene list from the results page and view past saved gene lists from your account page.
Enrichr now has two new gene set libraries: transcription factor loss of function or gain of function followed by expression and drug perturbation followed by expression. The two libraries were created by processing data from GEO.
The transcription factor perturbation library was created by Kevin Hu, an MD student at Mount Sinai, and the drug perturbation library was created by Axel Feldmann a high school student that did a summer project in the Ma'ayan lab. You can watch their final summer project presentation here.
Enrichr now supports a more accurate enrichment analysis method that takes into account the levels of the differentially expressed genes or proteins. Instead of treating the input list of genes as a set where every gene has the same membership level, genes can now an associated number between 0 and 1 that represents its degree of membership in the input gene list.
To use a quantitative input list as an input, add a comma and the level of membership of that gene after the gene symbol, e.g., "BRCA1, 0.9". (Try the full example on the front page of Enrichr.) This number can represent the fold change in expression or the negative log of the p-value of the significance of the change.
In addition, the Histone Modification, ENCODE, and the Human and Mouse Gene Atlases gene-set libraries have been converted to quantitative gene-set libraries so this should improve the accuracy of the enrichment results with these libraries. Enrichr still supports input of gene lists without graded membership levels so it is completely backwards compatible.
|the Ma'ayan Lab
|Edward Chen
|Christopher Tan
|Yan Kou
|Neil Clark
|Avi Ma'ayan
1 Tutorial
- 1.1 Uploading a list
- 1.2 Browsing the results
- 1.3 Understanding the bar graph
- 1.4 Understanding the data table
- 1.5 Understanding the grid
- 1.6 Understanding the network
- 1.7 Sharing and saving your results
- 1.8 Adjusting figure colors
- 1.9 Finding information about a specific gene
- 1.10 Using your account
2 FAQs
- 2.1 What is the difference between all the scoring methods?
- 2.2 Something broke! What do I do?
- 2.3 I have a great feature for you to add. How do I suggest it to you?
- 2.4 Why is my browser not supported?
- 2.5 How can I use Enrichr on my own site?
- 2.6 How can I use Enrichr programmatically with its API?
- 2.7 How can I use Enrichr to easily analyze RNA-seq data?
Enrichr uses a list of Entrez gene symbols as input. Each symbol in the input must be on its own line. You can upload the list by either selecting the text file that contains the list or just simply pasting in the list into the text box.
It is recommended to enter a description for your list so that multiple lists can be differentiated from each other if you choose to save or share your list.
If you are using a touch device, you can swipe left or right to navigate between the different tabs at the top.
On the results page, the analysis is divided into different categories of enrichment; in the example, the transcription category is shown. On a mobile device, you can switch between the categories by swiping left or right. Within each category, the enrichment analyses of various gene-set libraries are listed.
You can open a particular analysis by tapping on the name of the gene-set library, presenting a multitude of visualizations. On a mobile device, you can switch between the visualizations by swiping left or right. To return to switching categories on a mobile device, tap the name of the gene-set library to close the analysis.
The first visualization is the bar graph. You can sort the bar graph by the different score methods by clicking on the bar graph.
The length of the bar represents the significance of that specific gene-set or term. In addition, the brighter the color, the more significant that term is.
You can export the bar graph as a figure by clicking on one of the image format buttons to the top right of the bar graph.
The data table gives you a raw view of the data. By clicking on the column header, you can sort the table by the term, p-value, z-score, or combined score. Furthermore, you can filter the results by searching for a specific term.
Hovering over each row shows you the genes from the input that were found to be associated with that term. If the term name is highlighted in red, it means that you can click on the term name for additional information from external sites.
You can also get the table information in tab-delimited format by clicking on the "Export to Table" button.
NOTE: The grid may not be available for all gene-set libraries.
Each grid square represents a term and is arranged based on its gene-set similarity with other terms. It shows only the top 10 terms sorted by combined score. The brighter the square, the more significant that term is. Clicking on the grid allows you to toggle to an alternate view that colors the grid based on its correlation score with neighbors with white dots representing the significant terms.
The z-score and p-value is a measure of how clustered the top 10 terms are on the grid
NOTE: The network may not be available for all gene-set libraries.
Each node represents a term and a link between two nodes means that the two terms have some gene content similarity.
Initially, the network is force directed, but if you drag the node to a fixed position, it will stay there.
Like the other SVG figures, the network can be exported in three image formats.
Enrichr makes it easy to share your results with others. Simply click on the share icon to the right of the description box. It will provide you with a temporary direct link to your analysis that you can share with others.
In addition, you can register to have a user account within Enrichr. Having an account enables permanently saving lists on our server so you can return to them without the need to re-upload. Once logged in, you would need to click the save or share button for your list to be automatically associated with your account.
By default, all the figures have a red color scheme. However, you can change the color scheme by clicking on the cog-shaped icon to bring up a color picker. Selecting a color will change the color scheme of the bar graph, grid, and network figures.
On the "Find A Gene" tab from the main Enrichr page, you can look up which gene-set library terms your gene of interest belongs to.
Logging in or clicking on your name/email in the top right corner of the page while already logged in will take you to the account page for Enrichr. This table lists all the analyses that you have saved thus far. You can further filter the table for a particular list using the search box. Clicking on the list name will take you to the analysis.
On the "Account Settings" tab of the same page, you can change account details if you need to update any of your information.
Enrichr implements three approaches to compute enrichment. The first one is a standard method implemented within most enrichment analysis tools: the Fisher exact test. This is a proportion test that assumes a binomial distribution and independence for probability of any gene belonging to any set. The second test is a correction to the Fisher exact test that we developed based on intuition. We first compute enrichment using the Fisher exact test for many random gene sets in order to compute a mean rank and standard deviation from the expected rank for each term in the gene-set library. Then using a lookup table of expected ranks with their variances, we compute a z-score for deviation from this expected rank, this can be a new corrected score for ranking terms. Alternatively, we combined the p-value computed using the Fisher exact test with the z-score of the deviation from the expected rank by multiplying these two numbers as follows:
c = log(p) � z
Where c is the combined score, p is the p-value computed using the Fisher exact test, and z is the z-score computed to assess the deviation from the expected rank. Enrichr provides all three options for sorting enriched terms. In the results section, we show how we evaluated the quality of each of these three enrichment methods by examining how the methods rank terms that we know should be highly ranked.
Enrichr is in active development so it is possible that something can break during our updates. If it is a cosmetic bug, please try refreshing your browser (by pressing Ctrl+F5/Shift+F5/Command+F5). If that does not fix the problem, please send us your input file and how you reproduced the bug to help us fix the problem. When reporting a bug, please also include screenshots and the browser that you used. You can find our contact email on the about page.
Since we are always looking for ways to improve Enrichr, please use our contact email on the about page to send us feature suggestions.
Enrichr uses SVG to generate the figures and since Internet Explorer (IE) versions prior to IE 9 do not render SVG properly, Enrichr does not work with these browsers. In addition, the stock browser in Android 2.3.7 (Gingerbread) or below does not support SVG either; however, Firefox for Android and Opera for Android are viable alternatives. You can see a complete table of SVG compatibility across various browsers here.
You can include Enrichr on your site with some simple JavaScript:
function enrich(options) { var defaultOptions = { description: "", popup: false }; if (typeof options.description == 'undefined') options.description = defaultOptions.description; if (typeof options.popup == 'undefined') options.popup = defaultOptions.popup; if (typeof options.list == 'undefined') alert('No genes defined.'); var form = document.createElement('form'); form.setAttribute('method', 'post'); form.setAttribute('action', 'http://amp.pharm.mssm.edu/Enrichr/enrich'); if (options.popup) form.setAttribute('target', '_blank'); form.setAttribute('enctype', 'multipart/form-data'); var listField = document.createElement('input'); listField.setAttribute('type', 'hidden'); listField.setAttribute('name', 'list'); listField.setAttribute('value', options.list); form.appendChild(listField); var descField = document.createElement('input'); descField.setAttribute('type', 'hidden'); descField.setAttribute('name', 'description'); descField.setAttribute('value', options.description); form.appendChild(descField); document.body.appendChild(form); form.submit(); document.body.removeChild(form); }
To use it, simply call
enrich({list: genes}) in your JavaScript and pass in
genes as a list of Entrez Gene symbols separated by newlines. You can include a description for the list by using
enrich({list: genes, description: descString}). To have the results pop up in a new window, use
enrich({list: genes, popup: true}).
|List of gene symbols to enrich, separated by new lines
|String describing what the gene symbols represent
|String describing the gene-set library you want to enrich with
|String describing the filename you want to save to
|String describing the gene-set library you want to enrich with
We have provided a simple python script to take the cuffdiff output from Cufflinks, find the significant genes of all the comparisons, and run it through Enrichr.
To run this script, you have to have Python 2.7.3 installed and Python library, poster. The library can also be easily installed using easy_install.
To run the script on the
example file, open command line and go to the directory where the
script is stored and type
python cuffdiff2links.py example.diff. Press Enter to run the script.
After successfully running the script, two files,
updown.txt and
enrichrLinks.txt, will be generated.
updown.txt contains the significant genes of all the comparisons and
enrichrLinks.txt contain the links to Enrichr that you can copy and paste into your browser to see the result.


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and found 8 items
85cc, 8bhp, 50mph, Insurance group 2
The 'updated' version of Honda's bum-basic commuter only needed a few upgrades over the original 1960's design – CDI ignition is the main benefit, reducing maintenance. Otherwise, it's still the crude but charming plod-along it always was – only emissions killed it off in the EU, variants of the Cub are still on sale in Asia.
50cc, 6bhp, 50mph, Insurance group 2
The Aprilia RX50 has the looks of a proper enduro bike, but none of the performance. Restricted, it'll struggle to break 30mph, and de-restricted (illegal for 16 year-olds) it'll top 50 eventually. The chassis will cope with gentle off-roading, but ride it harder and the RX50 will be out of its depth.
500cc, 27.5bhp, 82mph, Insurance group 6
This new version of the Enfield Electra may look the same, and to be fair in alot of ways that count it is, but in fact it features an all new unit construction engine with fuel-injection, dragging it kicking and screaming into this century to meet Euro 3 emission laws. This is a motorcycle with alot of charisma- a throwback from a bygone ...
595cc, 45bhp, 100mph, Insurance group 9
The Yamaha XT600E is about as straightforward, reliable and solid as an old school trail bike gets. The Yamaha XT600E was the last of a long line of 4-valve air-cooled Yamaha singles, starting off with the original, much-loved XT500 of the mid-70s. This is a true trailie: decent off-round and straightforward and ujn-fussy on. Don't expect any frills or motorway ...
644cc, 39bhp, 92mph, Insurance group 8
The Honda SLR650 is a fairly joyless machine that barely redeems itself as a reasonably efficient commuter. Essentially it's a more heavily road-biased Dominator built at Honda's plant in Spain, back in the days when the Continental factory's quality control occasionally went adios. A Honda CB500 is simply miles better.
498cc, 48bhp, 110mph, Insurance group 8
The Kawasaki ER-5 has a straightforward parallel-twin middleweight commuter that's as easy to use as a pair of pants. As a cheap workhorse you won't find much wrong with the Kawasaki ER-5 - providing your expectations don't go beyond simply getting from A to B.
598cc, 52bhp, 105mph, Insurance group 11
CCM'S 604 came in a wide variety of styles; from supermoto to green laner to roadster. But mechanically each one was essentially the same hardy Rotax motor and quality suspension propelling an oil-in-the-frame chassis. Although they made way for the Suzuki-engined 644 in 2003 the older 604 is still a good, cheap motorcycle providing you look after it.
904cc, 70bhp, 117mph, Insurance group 12
Cagiva's Gran Canyon is a great motorcycle to ride, with nimble handling, lazy, easy-to-love power and plenty of tuning potential. Sadly, though, it's let down by crummy component quality and ridiculous servicing costs. It shines around town or on A-roads, but it's a less assured performer on longer, faster routes.
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subset: commoncrawl


text:
Well, let's see. I've already thrown a pair of shoes up against the wall (twice) and smashed a flashlight. What else can I destroy that I don't have to clean up later?
Posted 1 year ago
1 note
About My Vicky Life
Copyright © 2011–2014 My Vicky Life. Powered by Tumblr.
Simple Things theme by Dan Hauk.


text:
DMT Carbon Sole Replaceable Heel Tabs - Mens - Road Bike Shop
Road Bike Shop
Shop > Men's Apparel Clothing > Men's Apparel Road Bike Clothing > Men's Apparel Road Shoes >
DMT Carbon Sole Replaceable Heel Tabs - Men's
Price: $5.00buy now
When you spend a small fortune on your cycling shoes, you want them to last. And while they're designed for hours and hours of spinning the cranks, if you spend a fair amount of time shuffling in and out of coffee shops or find yourself wearing them at the races for more than just the race, the heels will wear away faster than your cleats. For this reason, DMT designed Carbon Sole Replaceable Heel Tabs. These tabs screw easily into place with two small Phillips head screws. The screws are coated with red Locktite to keep them in place yet allow for easy replacement. The DMT Carbon Sole Replaceable Heel Tabs come in a package of two.


text:
Kitchen Express Pot Likker Soup
This soup would be wonderful alongside a bowl of hoppin' John.
Yield: Makes 6 to 8 servings
More From Southern Living
Recipe Time
Cook Time:
Prep Time:
- 1/2 pound smoked boneless pork loin, chopped
- 1 medium onion, chopped
- 1 medium carrot, diced
- 1 tablespoon vegetable oil
- 1 garlic clove, chopped
- 1/2 cup dry white wine
- 2 tablespoons jarred ham soup base
- 1 (14.5-oz.) can vegetable broth
- 8 cups water
- 1/4 teaspoon dried crushed red pepper
- 1/2 (16-oz.) package fresh collard greens, washed and trimmed
- Cornbread Croutons
- 1. Sauté pork, onion, and carrot in hot oil in a Dutch oven over medium heat 4 to 5 minutes or until tender; add garlic, and cook 1 minute. Add wine; cook, stirring occasionally, 2 minutes or until wine is reduced by half.
- 2. Stir in ham soup base, broth, water, and red pepper. Bring to a boil. Gradually stir in collards; reduce heat, and simmer 45 minutes or until collards are tender. Serve with Cornbread Croutons.
My Notes
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Kitchen Express Pot Likker Soup Recipe at a Glance
- COURSE: Soups/Stews
- CONVENIENCE: Make-Ahead
- CUISINE: American, Southern
- MAIN INGREDIENT: Pork, Vegetables
- OCCASION: Autumn, Winter
- PUBLICATION: Southern Living
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text:
The perfect writing lesson for my young Nerdfighters.
HELLO! Because there have been so many nice people on tumblr who have been helping me to get all these event pokémons and stuff and I know how hard it i get these mons, now is your change. I am doing giveaway. Changes what you can get you can see up.
Rules are:
- You don't have to follow me.
- I only count reblogs.
- Please, don't be greedy, if you really don't need them, give change to someone else.
- No giveaway-only-blogs.
- I will allot three winners: 1st person will get two of the these pokémon of their choice, 2nd will choose one from left ones and 3th will get one which is left.
- Giveaway ends 24th January
- Be sure your askbox is open, if is not I will draw another winner in 24hours.
(Source: bloomelaa)
Golf ball hitting steel at 150mph, recorded at 70 000fps
physics is so fucked up
(Source: azzatron4000)
Farting in class:
Farting at home:
Gibson Les Paul Steampunk
Is it sad that I slid the unlock bar
I laughed at ever single one of these oh gawd.
(Source: giveme-lovesaf)
Design by Simon Fletcher. Powered by Tumblr.
© Copyright 2010


text:
Study: Dogs Can Imitate Human Actions And Store Them In Memory
July 16, 2013 by UPI - United Press International, Inc.
BUDAPEST, Hungary (UPI) — Dogs can learn and replay actions taught by humans after a short delay, European scientists say, evidence of dogs' ability to both encode and recall actions.
Claudia Fugazza and Adam Miklosi of Eotvos Lorand University in Hungary said they set out to determine if dogs possess a cognitive ability knows as deferred imitation, the ability to perform a task after a delay between being shown the task and being asked to perform it.
In a study published the journal Animal Cognition, they reported dogs were able to imitate human actions after delays ranging from 40 seconds to 10 minutes, during which time the dogs were distracted by being encouraged to take part in other activities.
Dogs are able to reproduce familiar actions and novel actions after different delays, they said; familiar actions after intervals as long as 10 minutes, novel tasks after a delay of 1 minute.
Domestic dogs are known to rely human communication cues, the researchers said, learning by observing humans.
Living in human social groups may have favored their ability to learn from humans, they said.
"The ability to encode and recall an action after a delay implies that the dogs have a mental representation of the human demonstration," the researchers wrote. "This would be so-called 'declarative memory,' which refers to memories which can be consciously recalled, such as facts or knowledge."


text:
The New York State Court of Appeals in Albany handed the State Senate back to Republican control Monday by ruling against a hand recount in the between , D - Port Washington, and , R, I, C. The unanimous 6-0 decision came down just before 5 p.m. Monday afternoon, validating the ruling of the , where Martins was first out of 80,000-plus cast. The final certified tallies had Martins winning with 42,942 ballots cast in his favor compared with 42,491 for Johnson.
The ruling brings to an end a where attorneys for both campaigns argued back and forth over the issue of a full hand recount of the race after during an audit of seven of the 249 machines used in the race. The discrepancies amounted to a net change of two additional votes in Johnson's favor.
"The State (regulations) don't address how you calculate the rate of error," Justice Victoria Graffeo said, asking Martins campaign attorney Peter Bee how he proposed to calculate the rate. Justice Robert Smith posed the question of what if a candidate could pick up 50 votes, "wouldn't that suggest gee we maybe better look at the whole thing?"
Bee argued that "if it can be shown that the machine broke down, then you can look at the paper inside that machine, and that was done," adding that outside of the original seven. In its five-page decision, the Court of Appeals found that "there is no evidence that these discrepancies were the result of any misconduct."
Johnson campaign attorney Steven Schlesinger had argued before the various courts that the discrepancies amounted to an error rate in excess of that allowed under the law, requiring a full hand count. Supreme Court justice Ira Warshawsky "exercised his discretion... concluded he did not need expert testimony to do the math and wound up finding that an extra two or three votes in some number of the machines would not have altered the outcome and saw no productivity in a further audit," Bee said in front of the court.
"I sought a hand recount not only to verify this election, but also to establish a precedent for all future close elections," Johnson said in a statement issued shortly after the decision. "I thank the courts for their due consideration, but still believe that firm guidelines for such recounts are needed to uphold the democratic ideals that this government was founded upon."
The Second Department Appellate Court in Brooklyn on both parties' behalf. It was the Court of Appeals' finding that "regulations recognize that some level of discrepancy is inevitable," and that in order for the Supreme Court to order a recount, "the record must demonstrate the existence of a material discrepancy likely to impact upon the result of the election, or flagrant irregularities in the election process."
Watching the entire procedures Monday morning was Martins, perhaps surveying the Albany environment in which he will now inhabit for the next 2 years. In a statement, the Senator-elect thanked the various courts "for their careful and through examination and the volunteers who carried out the hand count" as well as constituents "who with great faith in our system, waited patiently for the results. Now it's time to focus on the transition so that we can begin working on the issues we committed to during the campaign: lowering taxes, cutting spending and getting New Yorkers back to work."
A call placed to Johnson's office revealed that Johnson was busy trying to get in touch with Martins to offer a concession and best wishes to the new Senator-elect. "I congratulate Senator-elect Martins on his victory and wish him the best as the next representative of the 7th State Senate District," Johnson said in a statement. "I am truly thankful to those who supported me throughout my 10 years of public service in Nassau County and Albany, during this hard fought campaign, and during this lengthy - but vitally important - recount process. While I regret not taking part in this next Senate session, I wish our new governor and his partners in the Legislature, including Jack Martins, the wisdom and judgment to directly address the many challenges facing this state."


text:
- How Hurricane Sandy Stole Summer: Fort Tilden Beach will be closed all summer.
- Most important news of the decade— TV show Whose Line Is It Anyway is returning to TV! Colin! Ryan! POINTS DON'T MATTER!
- An MFA student at SVA puts 68 viles of semen in a refrigerator for final project, which begs the question "Did we all begin as pieces of art?"
- Celebrate National Peanut Butter Lover's day by visiting these restaurants and ordering their legume-themed dishes [or just go to Duane Reade and pick up a jar of Jif and a pack of Oreos, like we're going to do].
-Take this surprisingly poignant quiz to find out which Jurassic Park dinosaur you are.
Have a great weekend!
Photo of the Day by Caleb Savage.


text:
Archive for September 17th, 2014
Sony Bravia KDL19M4000/S M-Series 19-inch LCD HDTV – $234 Shipped
Dell has a limited time coupon that is expiring in just a few days time. They've got the Sony Bravia KDL19M4000/S M-Series 19-inch LCD HDTV for a super low. This set boasts a 1440x900 resolution, built-in HD tuner, 1x HDMI inp...
Amazon Deals
Sony ICF-CDK70 Under Cabinet Kitchen Clock Radio with CD-Changer – $76 Shipped
Amazon has the Sony ICF-CDK70 Under Cabinet Kitchen Clock Radio with CD-Changer for a low price. It's $76.16 + free shipping = $76.16 shipped! Features include a CD changer, FM/AM radio and under cabinet mount. (more…)
Sony BRAVIA KDL-32XBR9 32-inch LCD TV – $850 Shipped
PC Connection has the lowest price on the Internet for the Sony BRAVIA KDL-32XBR9 32" LCD TV. It features a 1920x1080 resolution, 4000:1 contrast ratio, built-in HD tuner and HDMI input. They've got it for (more…)
Xbox 360 Fishing Pole Coming This Fall
Call it fake all you want, but the Xbox 360 fishing pole is the real deal, at least according to Unscripted360. It's set to launch with The Hunt and The Strike video game, which features 'realistic lake bottom topography, advan...
Aliph Unveils Jawbone Prime
Aliph unveiled their latest Jawbone headset today, the Prime. The biggest changes to the high end Bluetooth headset is a slightly more refined facade with additional colors to choose from, Bluetooth 2.1 +EDR, and a slightly tw...
Flash Drives
Nano Sized 8GB Flash Drive Fits The Macbook Air Flush
How do you add 8GB of additional storage to your Macbook Air without cracking open the machine? Simple, you buy the EagleTec USB Nano Flash Drive. As you can see from the pic it's so damn small that it runs flush with the Air...
NES Modded Into A Purse (video)
Jeri Ellsworth means business. Video game business that is. She's taken a lady's purse and modded it out with a 7-inch LCD screen from a portable DVD player, some sort of chip that lets her run NES games, two NEW controllers ...
Cell Phones
Gadget Leak: LG Env3 Rear Gets Pictured
The LG Env3 is hardly a phone that warrants too much attention, but since it's probably just around the corner from being released I can't help myself (plus it makes for a good follow up article when it does launch). Pictured ...
Gadget Concept: Zip Up Headphones
There is one thing for sure about headphones: they get tangled. No matter what you do, or what gadgetry is employed you'll eventually end up with a knot or worse yet a rat's nest of cordage. Although the Zip Up Headphones conc...
Apple MB467LLA 13.3-inch MacBook Notebook – $1,439 Shipped
MacConnection has the lowest deal I've seen on the Apple MB467LLA 13.3-inch MacBook Notebook. This machine includes a 2.4GHz Intel Intel Core 2 Duo, 2GB DDR3 RAM, 250GB hard drive, WiFi b/g/n, DVD burner and 13.3-inch LCD. They...
Buy.com Deals
Acer Computer Aspire AS5535-6901 15.6-inch Notebook PC – $550 Shipped
Buy.com is offering a Net low for the Acer Computer Aspire AS5535-6901 15.6-inch Notebook PC. This computer boasts a 2Ghz AMD Athlon X2 Dual-Core QL-62 processor, 2GB of RAM, 160GB hard drive, 15.6-inch LCD, 3x USB 2.0 ports, W...
Pioneer DEH-1100MP CD Receiver – $80 Shipped
Newegg has the Pioneer DEH-1100MP CD Receiver for a solid deal. This receiver includes an AUX input, remote and 50w x 4 power. They've got it for (more…)


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2014 Summer Sizzler in Humboldt
Estevan Comprehensive School Graduation Class Of 2014
Estevan Comprehensive School Graduation Class of 2014
Bantam AA Bruins vs Regina Monarchs
Muslim booklet aims to combat extremism's lure
Victim's father wants answers from Magnotta trial: Lawyer
Russia and China absent from Toronto space conference
Rally for woman who died while in border agency custody
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The Indiana Pacers have received some great news heading in to their Game 6 match up against the New York Knicks. George Hill was listed as questionable coming in today as he continues to deal with a concussion, but just a few hours before tip off we learned that Hill had been medically cleared for tonight's game and he will be in the line up as they look to eliminate the Knicks from the postseason in front of the home crowd.
Hill's importance can easily be seen on the stat line. When Hill is on the court, the team is shooting 43 percent. Without him, the Pacers shoot 37 percent from the field. His impact is undeniable and he will provide a huge boost for the team tonight.
Here is the official release from the Pacers:
What time do the Knicks and Pacers tip off? We've got all of the information you will need to know to make sure you don't miss out on any of the action.
Start time: 8:00 p.m. ET
Location: Indianapolis, IN
Venue: Bankers Life Fieldhouse
Series Score: Pacers lead series, 3-2
TV Info: ESPN
Live Stream: Watch ESPN (may be blacked out in your area)
We hope that you enjoy Saturday's action and check back in with FanSided.com throughout the day and duration of the playoffs as we keep you up to date with the latest news and rumors.
Tags: George Hill Indiana Pacers


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Need a new system
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text:
From Wikipedia, the free encyclopedia
dirname is a standard UNIX computer program. When dirname is given a pathname, it will delete any suffix beginning with the last slash (
'/') character and return the result. dirname is described in the Single UNIX Specification and is primarily used in shell scripts.
The Single UNIX Specification specification for dirname is.
dirname NAME
For example:
$ dirname /usr/home/carpetsmoker/dirname.wiki /usr/home/carpetsmoker
dirname accepts only one operand, its usage within the inner loop of shell scripts can be detrimental to performance. Consider
while read file; do dirname "$file" done < some-input
The above excerpt would cause a separate process invocation for each line of input. For this reason, shell substitution is typically used instead
echo "${file%/*}";
See also[edit]
External links[edit]
dirname: return the directory portion of a pathname – Commands & Utilities Reference, The Single UNIX® Specification, Issue 7 from The Open Group
dirname(1): strip nondirectory suffix from filenames – Linux User Commands Manual


text:
The 2 Hour chart shows a down cycle has finally started after tagging the upper BB60. The BB20 midline (1.32681 and rising) should offer support. If support holds expect the price action to reverse back up towards the upper bands. If support break down, the price action should continue on down towards the stronger support offered by the lower BB20 (1.32283) before reversing back up.
The Daily chart bar patterns favor the first scenario.


text: In 1973, when he won an Oscar for his acting in The Godfather, Marlon Brando rejected the award to protest the treatment of Native Americans by the American film industry. He asked Sacheen Littlefeather, an actress that he knew through activist circles, to make a statement on his behalf onstage. The producer of the Oscars threatened to have her arrested if she spoke for more than 60 seconds, so she could only deliver a snippet of the speech (the full text is here). Ironically, Littlefeather says that this speech caused her to be boycotted by Hollywood; she didn't act professionally again. Today she's a civil rights activist in Northern California.


text:
World Fuel Services announced today at EBACE that Harrods Aviation, located at Stansted and Luton airports, is joining its Air Elite FBO network, becoming the first facility in the UK to do so. The deal brings the total number of FBOs in the network, established by World Fuel in late 2011, to 29 worldwide. Both of Harrods' FBOs provide convenient access to London.
London Stansted Airport now has a fifth FBO with the opening this month of the new Fayair operation. The 35,747-sq-ft facility is the result of a $19.2 million investment by Mohamed Al Fayed, former owner of the Harrods Aviation FBO immediately opposite the new Fayair building.
Harrods Aviation (Booth No. 4263) is here at the NBAA convention promoting its helicopter transfer service from London-area airports such as Biggin Hill, Farnborough, Luton and Stansted to the London Heliport at Battersea in the west of the city. The company believes the operation, which provides easy access to London's West End, is virtually unknown among U.S. corporate travelers. When flying into Stansted or Luton airports, visitors can take advantage of the amenities at the Harrods FBOs.
Universal Aviation opened its refurbished FBO at London Stansted Airport today. The 10,712-sq-ft facility now features crew and passenger lounges, as well as a business center with video-conferencing capability, two meeting rooms, flight-planning center, showers and changing rooms.
Here in the Dubai sunshine it is easy to forget the extent to which snow and ice can delay and disrupt aircraft operations, especially in the world of business aviation where schedules can be tight yet priority at snowbound airfields is low.
The Harrods Aviation FBOs at London Luton and Stansted airports, as well as helicopter charter operator Air Harrods, have been sold as part of a $2.2 billion transaction that saw Qatar Holdings acquire the Harrods retail group from Mohammed al-Fayed last month.
Harrods Aviation has unveiled a comprehensive redesign and refurbishment of its FBO at London Stansted Airport. In work spanning six months, the company has spent more than $1.5 million to give the place a fresh look.
Harrods Aviation has made special arrangements with the UK Border Agency (UKBA) for business aircraft passengers and crew to be able to complete immigration procedures at its London Luton Airport FBO.
Harrods Aviation has made special arrangements with the UK Border Agency (UKBA) for passengers and crew to complete immigration procedures at its London Luton Airport FBO.
London-area FBO chain Harrods Aviation has opened its new 8,000-sq-ft facility at London's Luton Airport. The expanded premises, which immediately adjoin the company's existing 2,000-sq-ft building, include a larger lounge, private VIP lounge, conference suite, flight-planning room and handling office. Crews now have their own lounge with Internet access. An enlarged 90,000-sq-ft ramp is immediately accessible from the building.
- Page 1
- ››


text:
Arsenal tube station
From Wikipedia, the free encyclopedia
|Local authority
|Managed by
|London Underground
|Number of platforms
|London Underground annual entry and exit
|2.005 million[1]
|2.735 million[2]
|Lists of stations
Arsenal tube station is a London Underground station in Highbury, north London. It is on the Piccadilly Line, in Travelcard Zone 2. It is between Holloway Road and Finsbury Park. It was originally known as Gillespie Road, but was renamed in 1932 after Arsenal Football Club. At that time the team played at the nearby Arsenal Stadium. It is the only Tube station named directly after a football club.[3] Arsenal Stadium closed in 2006, but the station retains its name and is still used by spectators attending matches at Arsenal's new Emirates Stadium. However, it is still quieter than other stations on the same stretch of line.
References[change | change source]
- ↑ "Customer metrics: entries and exits: 2004". London Underground performance update. Transport for London. http://www.tfl.gov.uk/tfl/corporate/modesoftransport/tube/performance/entriesandexits.asp?id=10&agekey=2004. Retrieved 26 December 2012.
- ↑ "Customer metrics: entries and exits: 2007". London Underground performance update. Transport for London. http://www.tfl.gov.uk/tfl/corporate/modesoftransport/tube/performance/entriesandexits.asp?id=10&agekey=2007. Retrieved 26 December 2012.
- ↑ Several tube stations, including West Ham and Wimbledon, share their names with football clubs, but only Arsenal was named directly after a club rather than the associated area.
Further reading[change | change source]
- Butt, R.V.J. (October 1995). The Directory of Railway Stations: details every public and private passenger station, halt, platform and stopping place, past and present (1st Edition ed.). Sparkford: Patrick Stephens Ltd. ISBN 1-8526-0508-1. OCLC 60251199.
- Jowett, Alan (2000). Jowett's Nationalised Railway Atlas (1st ed.). Penryn, Cornwall: Atlantic Transport Publishers. ISBN 0-9068-9999-0. OCLC 228266687.
Other websites[change | change source]
|Wikimedia Commons has media related to: Arsenal tube station
- London Transport Museum Photographic Archive
|Preceding station
|London Underground
|Following station
towards Uxbridge or Heathrow Airport
(Terminal 4 or Terminal 5)
|Piccadilly line
towards Cockfosters
Coordinates: 51°33′31″N 0°06′21″W / 51.55861°N 0.10583°W


text:
The Best Choice In Computer Services
Matthew is a member of The Motley Fool Blog Network -- entries represent the personal opinion of the blogger and are not formally edited.
One of the leaders in computer services, Computer Sciences Corporation (NYSE: CSC) provides a variety of services to its clients, including consulting, outsourcing, and systems integration. With shares more than doubling since their 52-week low of $22.19 hit last summer, but still about 20% below their pre-recession high, should investors wait for Computer Sciences to cool off a bit, or will the gains continue?
About CSC
As mentioned, Computer Sciences Corp offers consulting, outsourcing, and integration services to its clients. Their outsourcing services involve operating all or some of a company's computing infrastructure. This includes, among other things, applications development, network operations, data center management. They also provide business process outsourcing, which refers to things like call centers, or what people typically think of when they hear the term.
CSC's other services include systems integration (designing, developing, and implementing systems), consulting services, and some software system licensing services.
CSC competes with large computing services companies such as International Business Machines (NYSE: IBM) as well as smaller firms such as CACI International (NYSE: CACI).
IBM is one of the best known tech companies in the world, and has evolved into a systems, services, and software giant, in addition to producing the hardware products for which they are traditionally known. Last year, IBM earned just 17% of their revenues from hardware, while services and software contributed a combined 80%. This is why IBM is a threat to companies like CSC.
However, as a larger, more mature company, IBM's growth potential is not nearly as exciting, with 13% annual earnings growth projected over the next three years. That being said, IBM trades for a very reasonable 12.3 times forward earnings.
CACI, on the other end of the spectrum, is a much smaller IT company, and has a similar product and service profile to CSC. At just 9.6 times earnings, CACI looks to be the cheapest of the three, but this could be deceiving. CACI is projected to earn $6.51 per share this year, and then experience negative earnings growth averaging 2.5% for the next few years. This is a big red flag! Furthermore, the company's balance sheet is not too enticing. The company has just $15 million in cash and over $500 million in debt, which is very significant for a company whose market cap is just over $1.4 billion.
Valuation and Growth
At 17.6 times forward earnings, I actually think that CSC is cheap when considering its growth projections and very strong balance sheet. When the company announces fiscal year 2013's earnings next Wednesday, they are expected to report $2.75 per share. The analysts' consensus calls for this to rise to $3.49 and $4.09 in 2014 and 2015, respectively, for earnings growth of 27% and 17.2%, respectively. What's more is that the company has a positive net cash (cash minus debt) position, which is one of my favorite things to see in a prospective long-term investment. In fact, as a result of good management, the company's net cash position has consistently improved over the recent years.
The Bottom Line
When it comes to investing in these computer services companies, I'd say you either have to go mid-size or large. The little guys just have too many entry barriers to be competitive in this business. While IBM is a rock-solid company whose earnings are growing at a more-than-respectable pace, CSC does look like the more exciting play here. If you have a bit more risk tolerance, forward earnings growth of over 20%, a great balance sheet, and a decent dividend yield (1.7%) are a pretty enticing combination.
The Motley Fool's chief investment officer has selected his No. 1 stock for the next year. Find out which stock it is in the brand-new free report: "The Motley Fool's Top Stock for 2013." Just click here to access the report and find out the name of this under-the-radar company.
Matthew Frankel has no position in any stocks mentioned. The Motley Fool owns shares of International Business Machines.. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy. Is this post wrong? Click here. Think you can do better? Join us and write your own!


text:
Femslash February!
I think a lot of us in fandom can agree on one thing: f/f doesn't get enough love. So for the next month, let's try to do something about it.
I pledge to focus my creative energies on ships between women for the month of February. While m/m and m/f shipping is great, let's make this month all about the ladies.
I will make two fanworks—or more!—devoted to a lady ship. I'll use my creative power to increase the number of f/f fanworks out there and the awareness of these awesome ships. And I hope you'll join me in this.
How to participate?
Reblog this post!
If you're a fanwork creator—whether a fic writer, a fanartist, a graphic maker, or something else (fanmixes, podfic, cosplay, anything goes!): decide to focus on f/f for the month. Make (at least!) two fanworks for f/f pairings throughout the month. Tag them #femslash february.
Whether you're a creator or not: signal boost the shit out of this! Track the #femslash february tag! Show your love for the awesome works that are sure to come out of this!
Have questions? Just excited? Put it in the #femslash february tag or come talk to me, soaringrachel!
Let's get creating!


text:
Veera Kivimäki has joined us as a Client Team Director. She has a strong background of working with brands like Peroni and Pilsner Urquell at Servaali in Finland. Cheers Veera!
Copywriter Jani Tynnilä has joined us. Jani has worked previously at DDB Helsinki and SEK & GREY with clients like McDonald's, Snellman, Lidl and Sonera. Welcome Jani!
Basketball is growing fast in Finland. Beating top teams at Eurobasket showed how far the national team nicknamed Susijengi and the fans have come together. However, Finland had not directly qualified for the World Cup, but could apply for one of the wild card spots. It was time to tell the story of the Susijengi to the FIBA deciders… 358 helped with the application presentation and put together this accompanying video to show the passion of the team and the dedicated fans.
Design-kirpputorille, vaateostoksille, lätkätreeneihin vai ensi-iltaan? HSL lähettää bloggaajat ja tunnetut suomalaiset tutkimusmatkalle.
The Helsinki Regional Transport Authority (HSL) wanted to target older people, unfamiliar with public transport and the travel card. Interviews and research conducted by 358 revealed that while many of them had a positive attitude towards the service, many were hesitant to try it. The perceived difficultyof using the card and the reader was acting as a barrier to entry thus keeping people away from trial. 358 created a campaign highlighting the simplicity, and challenged people to conquer their offers. It was paired with an attractive offer: a free 2-week travel card, delivered to the home door.
Paper manufacturers need chemistry to make the kind of cardboard their customers want. To bring to life the expertise and solutions global chemicals company Kemira provides, 358 decided to show what happens in the process from the start of making board to the final product. The Board Experience is a zoomout that starts with a microscopic view showing chemicals influencing molecules. From there the story expands until we see the final product at the factory. Zoom out to see the big picture of how chemistry turns pulp into board a www.kemira.com/boardexperience
Part 2 of the Arla Protein campaign with Finnish Hip-Hop superstar Elastinen.
Arla Keittiön valmiit creme fraiche -maut tekevät kokkailusta yksinkertaista ja nopeaa – siis auttavat oikaisemaan keittiössä. Halusimme yhdessä asiakkaan kanssa kokeilla jotain uutta: luoda kategorialle epätyypillistä, erottuvampaa mainontaa. Vedimme siis itsekin mutkat suoriksi: nostimme huomiota herättävästi tekstit pääosaan ja jätimme tylsät raaka-ainekuvat vähemmälle.
Visitors in the Helsinki region only need 2 things: a camera and a day ticket for the public transport. With the ticket a tourist can travel freely on trams, the metro, buses, commuter trains and the Suomenlinna ferry – reaching practically every imaginable attraction in the area. Available for 1 to 7 days, the ticket also helps visitors to see more by saving time compared to walking. The ticket can be purchased from vending machines, R-kioskis, Helsinki Region Transport's (HSL) own service points and major department stores. The campaign was based on insights gathered through co-creational interviews with both visitors and stakeholders in the city's tourism industry. https://www.hsl.fi/en/dayticket
Younited is a new content cloud and collaboration tool created by our long-time client F-Secure. We helped F-Secure to come up with the name, brand identity and the tone of voice. The launch film is directed by Aleksi Koskinen.
Public Transportation in Helsinki was about to reach the mark of one million riders. We, together with Helsinki Regional Transport Authority (HSL) invited the Finnish photographer Lauri Eriksson to combine a brand advertising campaign, a community event and a cultural project by shooting an exhibition with the title 'Faces of Public Transportation'. The campaign was widely quoted in the press and even made the evening news. Everyone photographed will be invited to the opening of the physical exhibition later in Janury 2014. Watch MTV3 newsreport about the campaign.
See the whole website about the pictures.
Sometimes a hiphop star and word play can be the answer. Our client Arla wanted to launch their product Arla Protein – a quark with 20 grams of protein – with a bang. The hiphop-musician and judge in the popular Voice of Finland tv-show, Elastinen, was chosen as the face of the campaign. The copy Ela täysillä is a word play on his nickname "Ela" and the sentence "live fully." The campaign has been a pr and sale success. Elastinen's numerous Instagram and Facebook followers also enthusiastically took part in spreading the word.
The Finnish summer is filled with surprises – and it's not just the weather. We helped Arla launch a line of ready-made sour cream sauces that would give Finns the chance to be prepared for the unexpected. Such as: mother-in-law's unannounced visits, surprising successes on fishing trips and sudden cravings for beef. These "stories" also became the motifs for television commercials and outdoor and print ads.


text:
Title of service: Running Community Collections and Crowdsourcing
Status of Document: This document lists and describes the services offered by Academic IT Services in May 2013
1. Introduction
The Education Enhancement Team in IT services offer support to the collegiate University in building and enhancing online collections through crowdsourcing and community engagement. Initial advisory meetings, follow-up correspondence, short presentations and steering group representation in support of University projects and initiatives are free of charge. Significant work thereafter is available on a consultancy basis subject to resource availability. We work closely with departments, divisions and colleges to ensure value for money in the services, tools and websites you provide.
We offer professional expertise in:
In addition, we offer the following premium services:
2. Summary of responsibilities
2.1. Hours of Service
The service operates 9.00 a.m. to 5.00 p.m. Monday to Friday excluding University holidays. Service outside these times is negotiable.
Email queries sent to email@example.com will usually receive an initial response within five working days. An initial consultancy meeting will be offered free of charge. Requests for detailed advice or consultancy will be responded to on a reasonable efforts basis.
2.2. Overview of service
Please contact us to arrange an initial consultation.
2.3. Our approach
The Education Enhancement Team has a depth of experience in delivering crowdsourced projects, primarily using the Oxford Community Collection Model. Our work has been featured twice in the University Annual Review (2008 and 2012), and has received local, national and international press.
The measure of our success is the success of your projects and those of the University and we are able to work with you to implement frameworks for evaluating the impact of your work. The Education Enhancement Team want to advise in a way that works best for you, and we adopt a collaborative approach working with you. Pragmatic solutions are at the core of our approach, as are the needs of academia and the University. We are a team of accessible professionals who communicate effectively at all levels.
Where a project or activity is likely to make a contribution to knowledge beyond the University, we will work with the client to establish an appropriate dissemination route.
2.4. Charges
Initial advisory meetings and follow-up correspondence are free of charge. After this, any activities undertaken are charged as a premium service in line with IT services standard consultancy rates.
IT Services, through NSMS, offers a wide range of IT management services for digital projects which require from IT Services a level of IT support above the baseline service.
IT Services welcomes approaches to be a partner in projects led by other University bodies. The costing of IT Services participation in any such project must be agreed before any proposal is submitted to a funding body and will be undertaken in accordance with the University's policies on the costing and submission of research grant proposals.
Travel costs incurred for journeys outside Oxford will be charged to the client, as per the University's standard regulations.
3. Summary of clients' responsibilities


text:
"There are times when it will go so wrong that you will barely be alive, and times when you realise that being barely alive, on your own terms, is better than living a bloated half-life on someone else's terms."
Jeanette Winterson, Why Be Happy When You Could Be Normal? (via fleurlungs)


text:
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text:
|Lesbea (189 Videos)
|Lesbian, Lingerie
|2,811,717 ADDED May 10, 2012
|Eufrat, Iwia
|Lesbian, Masturbation, Oral Sex, Brunette, Caucasian, Vaginal Masturbation, Licking Vagina, Kissing, Shaved, Stockings, Lingerie, Tribbing
I want a pussy rubbed on my face like that,nom nom.
Here's a full length HD version of this video :D [Also remoove spacees]
eufrat looks like celeste starr
Winter is not the only thing that is coming
Wow, very good porn.
Just the sound of there voices makes me want to finger myself
the best video ever...
Omg I love this video sooo much. Eufrat's smile is so beautiful.
Mmm....so sweet and juicy
UHHH I'm so wet.......
Nice very nice
damn ! is so fucking good ! I'm really wet now
Eufrat is always so fucking sexy.
Im so wet!
frolicsome girls :-P
Beautiful :)
Feeling so horny after watching this, wish they were here to eat me out. ;)
so nice!
they are so damn good...
Meu Deus, me deixou louco !
Very hot, would join them gladly.
mmmmmmmmmmmmmmm that's fucking hot I love the part when she was riding on her face.
Eva Strauss ver cute
WTF Omg :D Hot Sexyyyyy Yeahhhhhhhhhhhhhhhhhhhhhh
stace32: would love to join you anytime!!
Holly shit this video is so fucking hot. Best lesbian video ever seen.
Oh boy, I want to be a pretty lesbian in my next life!
Wow! I came twice! Luv when she rides her face, one of my most fav *** m. mmmm. Mmmmm.... Cold shower time.....
Amazing...I love having my breasts sucked and licked...


text: Empire Level is the home of TrueBlue® – the most accurate vials in the world. The blue fluid in Empire level vials is a unique symbol of superior accuracy and a trademark of Empire Level Mfg. Corp. For over 90 years, Empire has been the leading designer and innovator of accurate and durable measuring tools for the professional and end user.


text:
Colon Cancer Treatment (Professional) (cont.)
Stage IV and Recurrent Colon Cancer
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Stage IV colon cancer denotes distant metastatic disease. Treatment of recurrent colon cancer depends on the sites of recurrent disease demonstrable by physical examination and/or radiographic studies. In addition to standard radiographic procedures, radioimmunoscintography may add clinical information that may affect management.[1] Such approaches have not led to improvements in long-term outcome measures such as survival.
Treatment options include the following:
Liver Metastasis
Approximately 50% of colon cancer patients will be diagnosed with hepatic metastases, either at the time of initial presentation or as a result of disease recurrence. Although only a small proportion of patients with hepatic metastases are candidates for surgical resection, advances in tumor ablation techniques and in both regional and systemic chemotherapy administration provide for a number of treatment options.
Hepatic metastasis may be considered to be resectable based on the following:[5,7,13,14,15,16]
For patients with hepatic metastasis considered to be resectable, a negative margin resection has resulted in 5-year survival rates of 25% to 40% in mostly nonrandomized studies, such as the NCCTG-934653 trial.[5,7,13,14,15,16] Improved surgical techniques and advances in preoperative imaging have allowed for better patient selection for resection.
Patients with hepatic metastases that are deemed unresectable will occasionally become candidates for resection if they have a good response to chemotherapy. These patients have 5-year survival rates similar to patients who initially had resectable disease.[17] Radiofrequency ablation has emerged as a safe technique (2% major morbidity and <1% mortality rate) that may provide for long-term tumor control.[18,19,20,21,22,23,24] Radiofrequency ablation and cryosurgical ablation [25,26,27,28] remain options for patients with tumors that cannot be resected and for patients who are not candidates for liver resection.
Other local ablative techniques that have been used to manage liver metastases include embolization and interstitial radiation therapy.[29,30] Patients with limited pulmonary metastases, and patients with both pulmonary and hepatic metastases, may also be considered for surgical resection, with 5-year survival possible in highly-selected patients.[12,31,32]
The role of adjuvant chemotherapy after potentially curative resection of liver metastases is uncertain. A trial of hepatic arterial floxuridine and dexamethasone plus systemic fluorouracil (5-FU) and leucovorin compared to systemic 5-FU plus leucovorin alone showed improved 2-year progression-free survival (57% vs. 42%, P = .07) and overall survival (OS) (86% vs. 72%, P = .03) but did not show a significant statistical difference in median survival, compared with systemic 5-FU therapy alone. Median survival in the combined therapy arm was 72.2 months versus 59.3 months in the monotherapy arm (P = .21).[33][Level of evidence: 1iiA]
A second trial preoperatively randomly assigned 109 patients who had one to three potentially resectable colorectal hepatic metastases to either no further therapy or postoperative hepatic arterial floxuridine plus systemic 5-FU.[34] Of those randomly assigned patients, 27% were deemed ineligible at the time of surgery, which left only 75 patients evaluable for recurrence and survival. While liver recurrence was decreased, median or 4-year survival was not significantly different. Further studies are required to evaluate this treatment approach and to determine if more effective systemic combination chemotherapy alone may provide similar results compared with hepatic intra-arterial therapy plus systemic treatment.
Hepatic intra-arterial chemotherapy with floxuridine for liver metastases has produced higher overall response rates but no consistent improvement in survival when compared to systemic chemotherapy.[2,35,36,37,38,39] Controversy regarding the efficacy of regional chemotherapy led to initiation of a large multicenter phase III trial (CALGB-9481, now completed) of hepatic arterial infusion versus systemic chemotherapy. The use of the combination of intra-arterial chemotherapy with hepatic radiation therapy, especially employing focal radiation of metastatic lesions, is under evaluation.[40] Several studies show increased local toxic effects with hepatic infusional therapy, including liver function abnormalities and fatal biliary sclerosis.
Drug combinations described in this section include the following:
Treatment of Patients With Stage IV Disease
Treatment of patients with recurrent or advanced colon cancer depends on the location of the disease. For patients with locally recurrent and/or liver-only and/or lung-only metastatic disease, surgical resection, if feasible, is the only potentially curative treatment.
Hepatic metastasis may be considered to be resectable based on the following:[5,7,13,14,15,16]
For patients with hepatic metastasis considered to be resectable, a negative margin resection has been associated with 5-year survival rates of 25% to 40% in mostly nonrandomized studies.[41,42,43,44,45][Level of evidence: 3iiiDiv] Better surgical techniques and advances in preoperative imaging have improved patient selection for resection. In addition, multiple studies with multiagent chemotherapy have demonstrated that patients with metastatic disease isolated to the liver, which historically would be considered unresectable, can occasionally be made resectable after the administration of chemotherapy.[17]
Currently, there are seven active and approved drugs for patients with metastatic colorectal cancer:
When 5-FU was the only active chemotherapy drug, trials in patients with locally advanced, unresectable, or metastatic disease demonstrated partial responses and prolongation of the time-to-progression (TTP) of disease [46,47] as well as improved survival and quality of life for patients receiving chemotherapy, compared with the best supportive care.[48,49,50] Several trials have analyzed the activity and toxic effects of various 5-FU-leucovorin regimens using different doses and administration schedules and showed essentially equivalent results with a median survival time in the 12-month range.[51] Prior to the advent of multiagent chemotherapy, two randomized studies demonstrated that capecitabine was associated with equivalent efficacy when compared with the Mayo Clinic regimen of 5-FU-leucovorin.[52,53][Level of evidence: 1iiA]
First-line Multiagent Chemotherapy
Three randomized studies demonstrated improved response rates, progression-free survival (PFS), and OS when irinotecan or oxaliplatin was combined with 5-FU-leucovorin.[54,55,56] An intergroup study (NCCTG-N9741) then compared IFL with FOLFOX4 in first-line treatment for patients with metastatic colorectal cancer. Patients assigned to FOLFOX4 experienced an improved PFS (median, 6.9 months vs. 8.7 months; P = .014; hazard ratio [HR] = 0.74; 95% confidence interval [CI], 0.61–0.89) and OS (15.0 months vs. 19.5 months, P = .001; HR = 0.66; 95% CI, 0.54–0.82) compared with patients randomly assigned to IFL.[Level of evidence: 1iiA] Subsequently, two studies compared FOLFOX with FOLFIRI, and patients were allowed to cross over upon progression on first-line therapy, respectively.[57,58][Level of evidence: 1iiDiii] PFS and OS were identical between the treatment arms in both studies. Since the publication of these studies, the use of either FOLFOX or FOLFIRI is considered acceptable for first-line treatment of patients with metastatic colorectal cancer.
The Bolus, Infusional, or Capecitabine with Camptosar-Celecoxib (BICC-C) trial evaluated several different irinotecan-based regimens in patients with previously untreated metastatic colorectal cancer: FOLFIRI, mIFL, and capecitabine/irinotecan (CAPIRI).[59] The study randomly assigned 430 patients and was closed early due to poor accrual. The patients who received FOLFIRI had a better PFS than the patients who received either mIFL (7.6 months vs. 5.9 months, P = .004) or CAPIRI (7.6 months vs. 5.8 months, P = .015). Patients who received CAPIRI had the highest grade 3 or higher rates of nausea, vomiting, diarrhea, dehydration, and hand-foot syndrome. After bevacizumab was approved, the BICC-C trial was amended, and an additional 117 patients were randomly assigned to receive FOLFIRI/bevacizumab or mIFL/bevacizumab. Although the primary endpoint, PFS, was not significantly different, patients receiving FOLFIRI/bevacizumab had a significantly better OS (not yet reached with a median follow-up of 22.6 months vs. 19.2 months, P = .007). When using an irinotecan-based regimen as first-line treatment of metastatic colorectal cancer, FOLFIRI is preferred.[59][Level of evidence: 1iiDiii] (Refer to the PDQ summary on Nausea and Vomiting, and for information on diarrhea and dehydration refer to the Gastrointestinal Complications summary.)
Randomized phase III trials have addressed the equivalence of substituting capecitabine for infusional 5-FU. Two phase III studies have evaluated FUOX versus CAPOX.[60,61] The AIO Colorectal Study Group randomly assigned 474 patients to either FUFOX or CAPOX. The median PFS was 7.1 m for the CAPOX arm and 8.0 m for the FUFOX arm (HR = 1.17; 95% CI, 0.96–1.43, P = .117), and the HR was in the prespecified equivalence range. The Spanish Cooperative Group randomly assigned 348 patients to CAPOX or FUOX.[60] The TTP was 8.9 months versus 9.5 months (P = .153) and met the prespecified range for noninferiority.[60][Level of evidence: 1iiDiii] When using an oxaliplatin-based regimen as first-line treatment of metastatic colorectal cancer, a CAPOX regimen is not inferior to a FUOX regimen.
The Addition of Targeted Therapy to Multiagent Chemotherapy
Patients with previously untreated metastatic colorectal cancer were randomly assigned to either IFL or IFL and bevacizumab.[62] The patients randomly assigned to IFL and bevacizumab experienced a significantly better PFS (10.6 months in the group given IFL and bevacizumab, as compared with 6.2 months in the group given IFL and placebo; HR for disease progression = 0.54; P < .001) and OS (20.3 months in the group given IFL and bevacizumab, as compared with 15.6 months in the group given IFL and placebo corresponding to an HR for death = 0.66; P < .001).[62]
Despite the lack of direct data, in standard practice, bevacizumab was added to FOLFOX as a standard first-line regimen based on the results of NCCTG-N9741.[63] Subsequently, in a randomized phase III study, patients with untreated, stage IV colorectal cancer were randomly assigned in a 2 � 2 factorial design to CAPOX versus FOLFOX4, then to bevacizumab versus placebo. PFS was the primary endpoint. In this trial, 1,401 patients were randomly assigned, and the median PFS was 9.4 months for patients receiving bevacizumab and 8.0 months for the patients receiving placebo (HR = 0.83; 97.5% confidence interval [CI] 0.72–0.95, P = .0023).[64][Level of evidence: 1iiDiii] Median OS was 21.3 months for patients receiving bevacizumab and 19.9 months for patients receiving placebo (HR = 0.89; 97.5% CI, 0.76–1.03, P = .077). The median PFS (intention-to-treat analysis) was 8.0 months in the pooled CAPOX-containing arms versus 8.5 months in the FOLFOX4-containing arms (HR = 1.04; 97.5% CI, 0.93–1.16), with the upper limit of the 97.5% CI being below the predefined noninferiority margin of 1.23.[64,65] The effect of bevacizumab on OS is likely to be less than what was seen in the original Hurwitz study.
Investigators from the Eastern Cooperative Oncology Group (ECOG) randomly assigned patients who had progressed on 5-FU-leucovorin and irinotecan to either FOLFOX or FOLFOX and bevacizumab. Patients randomly assigned to FOLFOX and bevacizumab experienced a statistically significant improvement in PFS (7.43 months vs. 4.7 months, HR = 0.61; P < .0001) and OS (12.9 months vs. 10.8 months, HR = 0.75; P = .0011).[66][Level of evidence: 1iiA] Based on these two studies, bevacizumab can reasonably be added to either FOLFIRI or FOLFOX for patients undergoing first-line treatment of metastatic colorectal cancer.
There are currently no completed randomized controlled studies evaluating whether continued use of bevacizumab in the second line or third line after progressing on a first-line bevacizumab regimen is worthwhile.
Cetuximab/panitumumab and second-line chemotherapy
Second-line chemotherapy with irinotecan in patients treated with 5-FU-leucovorin as first-line therapy demonstrated improved OS when compared to either infusional 5-FU or supportive care.[67,68,69,70] Similarly, a phase III trial randomly assigned patients who progressed on irinotecan and 5-FU-leucovorin to bolus and infusional 5-FU-leucovorin (LV5FU2), single-agent oxaliplatin, or FOLFOX4. The median TTP for FOLFOX4 versus LV5FU2 was 4.6 months versus 2.7 months (stratified log-rank test, 2-sided P < .001).[71][Level of evidence: 1iiDiii]
Cetuximab is a partially humanized monoclonal antibody against the epidermal growth factor receptor (EGFR). For patients who have progressed on irinotecan-containing regimens, a randomized phase II study was performed of either cetuximab or irinotecan and cetuximab. The median TTP for patients receiving cetuximab was 1.5 months, and the median TTP for patients receiving irinotecan and cetuximab was 4.2 months.[72][Level of evidence: 3iiiDiv] On the basis of this study, cetuximab was approved for use in patients with metastatic colorectal cancer refractory to 5-FU and irinotecan.
The Crystal Study (NCT00154102) randomly assigned 1,198 patients with stage IV colorectal cancer to FOLFIRI with or without cetuximab.[73] The addition of cetuximab was associated with an improved PFS (HR = 0.85; 95% CI, 0.72–0.99, P = .048 by a stratified log rank test), but not OS.[73][Level of Evidence: 1iiDii] Retrospective studies of patients with metastatic colorectal cancer have suggested that responses to anti-EGFR antibody therapy are confined to patients with tumors that harbor wild types of KRAS (i.e., lack activating mutations at code on 12 or 13 of the KRAS gene). A subset analysis evaluating efficacy vis a vis KRAS status was done in patients enrolled on the Crystal Study. There was a significant interaction for KRAS mutation status and treatment for tumor response (P = .03) but not for PFS (P = .07). Among patients with KRAS wild-type tumors, the HR favored the FOLFIRI/cetuximab group (HR = 0.68; 95% CI, 0.50–0.94).
Importantly, patients with mutant KRAS tumors may experience worse outcome when cetuximab is added to multiagent chemotherapy regimens containing bevacizumab. In a randomized trial, patients with metastatic colorectal cancer received capecitabine/oxaliplatin/bevacizumab with or without cetuximab. The median PFS was 9.4 months in the group receiving cetuximab and 10.7 months in the group not receiving cetuximab (P = .01). In a subset analysis, cetuximab-treated patients with tumors bearing a mutated KRAS gene had significantly decreased PFS compared with cetuximab-treated patients with wild-type KRAS tumors (8.1 months vs. 10.5 months; P = .04). Cetuximab-treated patients with mutated KRAS tumors had a significantly shorter PFS compared with patients with mutated KRAS tumors not receiving cetuximab (8.1 months vs. 12.5 months; P = .003) as well as OS (17.2 months vs. 24.9 months; P = .03).[74][Level of evidence: 1iiDiii]
Panitumumab is a fully humanized antibody against the EGFR. In a phase III trial, patients with chemotherapy refractory colorectal cancer were randomly assigned to panitumumab or best supportive care. Patients receiving panitumumab experienced an improved PFS (8 weeks vs. 7.3 weeks, HR = 0.54; 95% CI, 0.44–0.66; P <.0001).[75][Level of evidence: 1iiDiii] There was no difference in OS, which was thought to be the result of 76% of patients on best supportive care crossing over to panitumumab. The FDA-approved panitumumab for use in patients with metastatic colorectal cancer refractory to chemotherapy.[75]
In the PRIME (NCT00364013) study, 1,183 patients were randomly assigned to FOLFOX4 with or without panitumumab as first-line therapy for metastatic colorectal cancer.[76] The study was amended to enlarge the sample size to address patients with the KRAS wild-type tumors and patients with mutant KRAS tumors separately. For patients with KRAS wild-type tumors, a statistically significant improvement in PFS was observed in those who received panitumumab-FOLFOX4 compared with those who received only FOLFOX4 (HR = 0.80; 95% CI, 0.66–0.97; P = .02, stratified log-rank test).[76][Level of evidence: 1iiDiii] Median PFS was 9.6 months (95% CI, 9.2 months–11.1 months) for patients who received panitumumab-FOLFOX4 and 8.0 months (95% CI, 7.5 months–9.3 months) for patients who received FOLFOX4. OS was not significantly different between the groups (HR = 0.83; 95% CI, 0.67–1.02; P = .072). For patients with mutant KRAS tumors, there was worse PFS with the addition of panitumumab (HR = 1.29; 95% CI, 1.04–1.62; P = .02, stratified log-rank test). Median PFS was 7.3 months (95% CI, 6.3 months–8.0 months) for panitumumab-FOLFOX4 and 8.8 months (95% CI, 7.7 months–9.4 months) for FOLFOX4 alone.
Similarly, the addition of panitumumab to a regimen of FOLFOX/bevacizumab resulted in a worse PFS and worse toxicity compared to a regimen of FOLFOX/bevacizumab alone in patients not selected for KRAS mutation in metastatic colon cancer (11.4 months vs. 10.0 months, HR = 1.27; 95% CI, 1.06–1.52).[77][Level of evidence: 1iiDiii]
In another study (NCT00339183), patients with metastatic colorectal cancer who had already received a fluoropyrimidine regimen were randomly assigned to either FOLFIRI or FOLFIRI plus panitumumab.[78] In a post hoc analysis, patients with KRAS wild-type tumors experienced a statistically significant PFS advantage (HR = 0.73; 95% CI, 0.59–0.90; P = .004, stratified log-rank).[78] [Level of evidence: 1iiDiii] Median PFS was 5.9 months (95% CI, 5.5 months–6.7 months) for panitumumab-FOLFIRI and 3.9 months (95% CI, 3.7 months–5.3 months) for FOLFIRI alone. OS was not significantly different. Patients with mutant KRAS tumors experienced no benefit from the addition of panitumumab.
It is unproven whether these EGFR agents should be combined or used in a sequential approach.
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV colon cancer and recurrent colon cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
eMedicineHealth Public Information from the National Cancer Institute
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Some material in CancerNet™ is from copyrighted publications of the respective copyright claimants. Users of CancerNet™ are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publication, all of which are hereby incorporated by reference.


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Maybury Farm Corn Maze 2013
Final Weekend: November 2 & 3, Noon - 7pm
Haven't made it out to the Corn Maze at Maybury Farm this fall? YOU'RE IN LUCK! The fall fun continues for one more weekend! Join us November 2nd and 3rd from noon to 7pm when you can visit the Corn Maze, see the animals and pick your pumpkin!
Our 12 acre Corn Maze has been a HUGE HIT this year with folks of all ages! The corn is very thick and tall and there's still time to see if YOU can wind your way through and try to find all eight of the wooden animals that are hidden throughout. Find all of the animals and you can be entered to win a Meijer Gift Card! Also included in your Corn Maze admission is a hayride to and from the Maze and admission to the Farm.
Need to warm up after your visit to the Maze? Stop in to our Welcome Center where we will have a toasty fire going to warm you up! Cider, hot chocolate and donuts are available for you to enjoy as well.
Visit the Northville Meijer (Service Desk), Community Financial Credit Union in Northville, Tom Holzer Ford in Farmington or Jack Demmer Ford (Service Center) and receive a 10% coupon off each Corn Maze admission!
All of the proceeds from the Corn Maze are used to pay for our winter feed bills for our animals.
November 2 & 3, Noon - 7pm
Groups of 15 or more may schedule Corn Maze throughout the week - call (248) 374-0200.
Corn Maze ticket includes:
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Northville Community Foundation, 18600 Northville
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Autogenic Drainage
From Physiopedia
Original Editor - The Open Physio project.
Top Contributors -
Autogenic drainage is a respiratory self-drainage technique that utilises controlled experitory airflow (tidal breathing) to mobilise secretions. It consists of three phases:
- Loosening peripheral secretions by breathing at low lung volumes (slow, deep air movement)
- Collecting secretions from central airways by breathing at low to middle lung volumes (slow, mid-range air movement)
- Expelling secretions from the central airways by breathing at mid to high lung volumes (shallow air movements)
The velocity or force of the expiratory airflow must be adjusted at each level of inspiration so that the highest possible airflow is reached in that generation of bronchi, without being high enough to cause the airways to collapse during coughing. Autogenic drainage does not utilise Postural Drainage positions but is performed while sitting upright.
- Choose a breath-stimulating position like sitting or reclining. Relax, with the neck slightly extended.
- Clear your nose and throat by blowing your nose and huffing.
Breathing in
- Slowly breathe in through the nose to keep the upper airways open. Use the diaphragm and/or the abdomen if possible.
- First take a large breath in, hold it for a moment. Breathe all the way out for as long as you can. Now you are at low lung volume. See picture below. The size of breath and level at which you breathe depends on where the mucus is located.
- Take a small to normal breath in, and pause. Hold your breath for about 3 seconds. All the upper airways should be kept open. This improves the even filling of all lung parts. The pause allows time for the air to get behind the mucus.
Breathing out
- Breathe out through the mouth. Keep the upper airways open. This is your glottis, throat and mouth. Breathing out is done in a sighing manner. When you force your breath out the airways can collapse. You will hear a wheeze.
- At low lung level breathing use your abdominal muscles. Squeeze all the air out until you can breathe out no more.
- You hear the mucus rattling in the airways when breathing the right way. Put a hand on your upper chest, and feel the mucus vibrating. High frequencies mean that the mucus is in the small airways. Low frequencies mean that the mucus is in the large airways. Using this feedback lets you easily adjust the technique.
- Repeat the cycle. Inhale slowly to avoid sending the mucus back down. Keep breathing at the low level until the mucus collects and moves upward. Signs of this are:
- Crackling of the mucus can be heard as you exhale.
- You feel the mucus moving up.
- You feel a strong urge to cough.
- The level of breathing is raised when any of the above occurs. Refer to the picture below. Moving the breathing from lower to higher lung area takes the mucus with it.
- Finally the collected mucus reaches the large airways where it can be cleared by a high lung volume huff. Don't cough until the mucus is in the larger airways. Cough only if a huff did not move the mucus to the mouth.
- You have now finished one cycle. Take a break of one to two minutes. Relax and perform breathing control before you start on the next cycle. The cycles are repeated during the session. A session lasts between twenty to forty-five minutes or until you feel all the mucus has been cleared. Do sessions of AD more often if you still have mucus present at the end of a session.
Paula Agostini and Nicola Knowles, Autogenic drainage: the technique, physiological basis and evidence, Physiotherapy, Volume 93, Issue 2, June 2007, Pages 157-163
Recent Related Research (from Pubmed)
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Ageing and Parkinson's Disease
In this month's Members topic we are developing our understanding of ageing and Parkinson's Disease. This month we have exclusive access to:
- 6 FREE chapters from text books Geriatric Physical Therapy edited by Andrew Guccione, Rita Wong & Dale Avers 2014 and A Comprehensive Guide to Geriatric Rehabilitation edited by Timothy Kauffman, Ronald Scott, John Barr & Michael Moran. 2014
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Nonprofit or community organization
Last modified: April 8, 2013, 8:51 PM
Bridges Public Charter School is an inclusive public school for students with and without special needs. Historically a preschool / pre-kindergarten program exclusively, we are now expanding into an elementary school program. The school will be adding a grade each year until reaching capacity with 5th grade in 2017-2018. For the 2013-2014 school year we will serve students in grades preschool – 1st grade.
Our mission is to provide an exemplary educational program that includes students with special needs. Our developmentally appropriate, student and family-centered educational approach will nurture students to expand their developmental skills, in order to build a foundation for life-long learning.
Bridges, the name of our school, symbolizes an inclusive learning community that builds bridges of understanding, awareness and support by connecting children and families with a variety of different needs, cultures and backgrounds.


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Ever heard of Ashtanga yoga? Julianne Moore swears by it. On the November cover of Health magazine, the actress dishes on how she stays fit, her family's eating habits, and her love of acupuncture.
Actress Julianne Moore is unstoppable these days, recently landing a spot in the blockbuster "Hunger Games: Mockingjay Parts 1 & 2."InStyle magazine, the 52-year-old says she's thankful for the trajectory of her career.
Oscar nominee Julianne Moore is joining the "Hunger Games" cast for "Mockingjay Parts 1 & 2."
Actress Julianne Moore officially signed on as the new spokesmodel for Reed Krakoff.
Moore will launch the brand's fall 2013 campaign. See some of the ad pics at E!
Moore has also been the face for L'Oréal, Bulgari and Talbots.
The NYPD said they are investigating the theft of 10 pieces of jewelry taken from Moore's Manhattan apartment several months ago.
The jewelry went missing between June 6 and August 28, while 15-25 workers were doing renovations on the actress' home in the West Village, police said on Thursday.
More than $127,000 worth of jewelry, including four Cartier watches, was stolen from actress Julianne Moore's home in New York City's West Village. Full Story at Business Insider
Someone call Snoop Dogg because Sunday night's Emmy red carpet was covered in platinum!
"Extra" was backstage in the 2012 Emmy Awards press room for immediate reactions and anecdotes from this year's winners, including Julianne Moore, Louis C.K., and Sofia Vergara. Find out what they had to say!


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Near the intersection of Friday's deadly Minneapolis shootout, friends identified fallen motorcyclist as 24-year-old Ivan Romero, and spoke to FOX 9 News as they were wrecked with grief.
2 shot, 2 killed in Minneapolis: http://www.myfoxtwincities.com/story/22220395/two-police-officers-shot-in-minneapolis-suffer-non-life-threatening-injuries
Ivan Romero Olivares' friend Leandro Camacho, fighting back tears, told FOX 9 out of respect for Ivan and his family, he had to stop, light a candle, and pray.
"For years, a good friend and unfortunately a lost life. His mom is in Mexico, she's just torn up. His mom all the family is broken," Camacho said.
According to Camacho, Ivan lived in the United States for the last six years, describing him as a kind human being. From his Facebook page, it's clear he was in love with his girlfriend, Joselin Torrejon.
Friday, Camacho said Ivan was eager to ride his motorcycle. He and Joselin were riding here on Blaisdell Avenue South and 26th when they collided with an MPD squad car.
Ivan is now gone, and Joselin is in satisfactory condition at Hennepin County Medical Center.
Ivan leaves behind plenty of family and friends in the area.
Saturday afternoon, Joselin posted a photo of herself and Ivan, with the caption "Te amo." I love you, written underneath. These are words his loved ones likely wished they had the chance to tell him just one last time.
Phone: (952) 944-9999
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On the ball
19 May 2003
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All too many lawyers conform to type. Austere, dry and measured, unafraid of their intellects, loath to mingle with the masses (trainees, junior assistants, minor clients) lest their status be compromised. But there are a few who buck the trend, and Simon Dowson-Collins, director of legal affairs at publishers HarperCollins, is one of them.
I meet Dowson-Collins at the Energize Centre, a gym in Hammersmith round the corner from HarperCollins' Fulham Palace Road office. He arrives by bike and proceeds to knock seven bells out of a boxing trainer at the gym. He is a fitness fanatic and is in excellent condition for a man approaching 40, although the curly locks of his early career went some time ago. Having barely broken sweat, Dowson-Collins hops on his bike and says he will see me back at the office. He is back at his desk, looking smooth and collected, in less time than it takes me to drive there.
Dowson-Collins joined HarperCollins in December 2001, after being headhunted from the BBC. He joined because he wanted to develop his career and experience what it was like to be part of a commercial organisation - somewhere, as he puts it, "where there's a bottom line, in contrast to the BBC, where principle determines everything". He heads a department with a total staff of 15, including three lawyers and nine contracts administrators and executives. He reports to chief executive officer Vicky Barnsley and chief operating officer John Bailey, with whom he says he has "an excellent relationship: they are utterly professional".
The work handled by Dowson-Collins and his department embraces everything from contract law to litigation, employment to acquisitions and disposals, and, of course, pre-publication law. Dowson-Collins is an expert in this area, having spent just over five years in the BBC's programme compliance department under veteran broadcast lawyer Glenn del Medico.
At the BBC, he was responsible for ensuring that programmes such as Have I Got News For You and They Think It's All Over did not land the BBC or the production companies in libel territory. "I would sit in the gallery on recording night with Jimmy Mulville [a director of Hat Trick Productions, the makers of Have I got News For You], the producer and other BBC programme makers. I had to watch the show being recorded over a period of an hour and a half, and then let them know which bits I thought were problematic." Surely it was fraught with all manner of difficulties? "These kind of satirical programmes are inherently risky," he says. "If you look at one of the definitions of libel - holding someone up to scandal, ridicule or contempt - you could say that anyone simply mentioned on them might have a cause of action. It's a question of assessing risk."
Dowson-Collins well remembers his first night legalling Have I Got News For You. "Jimmy Mulville looked at me and said, 'Ah, the new boy'. There was a lot of pressure, and always some heated debates before the final cut."
At the BBC, he was also responsible for programmes in Northern Ireland, a notorious minefield for pre-publication lawyers, and once a week he would be on news duty for a 24-hour stint. As a former captain of football teams at school, university and at county level, he is nothing if not active, not the kind of man to be chained to a desk for 24 hours. So was it hard? "Not really," he says. "I got used to receiving up to 60 calls a day, from 4.30 in the morning to midnight." However, he admits that he did manage to complete one shift while at his beloved Queen's Park Rangers. "The journalist who'd rung me said, 'You sound like you're at a football match'. I can't remember if Rangers won or not, but I do recall moving away from the crowd so that we could discuss things properly," he says.
Prior to the BBC, Dowson-Collins was a libel litigator with West End firm Davenport Lyons, which took over Wright Webb Syrett in March 1995. Although he qualified as a barrister in 1989, Dowson-Collins elected to become a solicitor four years later. At Wright Webb, he worked for the late, legendary Oscar Beuselinck, who, with Peter Carter-Ruck and Lord Goodman, represented something of a holy trinity among libel lawyers. Dowson-Collins remembers being interviewed by Beuselinck. "He asked me what he could do for me," he recalls. "I said he could offer me a job. He said 'Right', then rang a fellow partner and sent me downstairs to see him. Before I went he said: 'If he gives you a job, don't praise me. If he doesn't, don't blame me. Now F**k off out of here.'"
If this was typical of Beuselinck's abrasive style, so too was an attention to detail and belief in high standards that Dowson-Collins has never forgotten. "You couldn't give Oscar any document with even the smallest mistake. I learnt a tremendous amount working with him."
Dowson-Collins himself has less of the abrasiveness and more of the charm. A former colleague says: "He's bright and very professional, but somehow manages to be down-to-earth at the same time. He also has a great sense of fun."
No doubt he will have enjoyed one of HarperCollins' recent books, by fellow Staines inhabitant Ali G. Other books on the shelves in his office are more cerebral, but often Dowson-Collins finds himself involved in the contractual negotiations with authors and their agents rather than pre-publication advice, much of which is provided by libel chambers 5 Raymond Buildings. He has worked on the contract for David Beckham's forthcoming autobiography, as well as a compromise agreement by which HarperCollins and Jeffrey Archer parted company. This he is unable to discuss, owing to confidentiality undertakings, but he will say that there was "a great deal of negotiation to get it right". For a moment, a look of pride crosses his face, but Dowson-Collins will say no more, on or off the record.
Dowson-Collins says that he has no plans to move on, even if the headhunters come knocking again. "Why would I want to move?" he says. "HarperCollins is a fantastic place to work. I intend to stay as long as I keep enjoying it."
In the immediate future, there is the small matter of Queen's Park Rangers' bid for promotion to Division One. Dowson-Collins fondly recalls a summer spent training with the Queen's Park Rangers youth team, and loves his trips to Loftus Road. He waves his tickets for the second semi-final playoff at home to Oldham with unabashed enthusiasm. One thing's for sure: if QPR reach the playoff final at the Millenium Stadium in Cardiff, publishing's fittest lawyer will be there.
Simon Dowson-Collins
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Hi-Way's complete line of road maintenance and deicing equipment includes solutions for large and small truck, dump bodies, spreaders, tailgates, snowplows and pre-wet systems. The new Xzalt precision applicator increases your ROI by reducing fuel, product and maintenance costs.
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Highway Equipment Company, the manufacturer of New Leader® crop nutrient applicators, invites you to their 75th anniversary celebration in booth #203 at the Midwest Ag Industries Exposition (MAGIE), August 20,...