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Comparison of Catalytic Properties of Cytochromes P450 3A4 and 3A5 by Molecular Docking Simulation
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ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
Volume 8, 2 Issues, 2014
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Drug Metabolism Letters
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Comparison of Catalytic Properties of Cytochromes P450 3A4 and 3A5 by Molecular Docking Simulation
Toshiro Niwa, Motohiro Yasumura, Norie Murayama and Hiroshi Yamazaki
Showa Pharmaceutical University, 3-3165 Higashi-tamagawa Gakuen, Machida, Tokyo 194-8543, Japan
To investigate the reported differences in catalytic activities of cytochromes P450 (CYP or P450) 3A4 and 3A5, molecular docking studies were conducted of the interactions of 13 compounds with active sites of the reported three-dimensional structure of CYP3A4 and the modeled structure of CYP3A5. The primary sequence of human CYP3A5 was aligned with that of human CYP3A4 (1TQN) using three-dimensional modeling software. Docking simulations were carried out after the energy of the CYP3A4 and CYP3A5 structures had been minimized. Kinetic parameters for the substrate oxidations were taken from the literature. Among the substrates that are preferably metabolized by CYP3A4, including carebastine, itraconazole, haloperidol, and fluvastatin, the former three compounds was found to closely dock to the heme region of CYP3A4 but not to that of CYP3A5. The ligand–CYP3A5 interaction energies (U values) for vincristine, R- and S-verapamil, and β-endosulfan were considerably lower than the corresponding ligand–CYP3A4 interaction energies; these substrates also had lower reported Michaelis constants (Km) for CYP3A5 than for CYP3A4. Despite higher CYP3A5 Km values forα-endosulfan and estradiol, the CYP3A5 U value for estradiol was lower than that for CYP3A4. No marked differences of U values between CYP3A4 and CYP3A5 were observed for midazolam and triazolam, and comparable Km values for the oxidations of these two substrates have been reported for CYP3A4 and CYP3A5. Molecular docking simulation could partly explain the differences of the affinities (Km) of the substrates for CYP3A4 and CYP3A5 based on the accessibility of substrates to the heme moiety of CYP3A molecules
Accessibility, Affinity, CYP3A4, CYP3A5, docking simulation, metabolic activity
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Female ice sledge hockey players will be allowed to participate in the Vancouver 2010 Paralympic Games, according to a new provision by the International Paralympic Committee (IPC).
In reponse to numerous requests from the nations regularly practicing the sport, the IPC's governing board has approved an entry provision to allow qualified teams to add female athletes to their roster if they wish.
The inclusion of female athletes for sledge hockey is a step in the direction of promoting greater female participation in this sport and the Paralympic Winter Games in general.
The tournament designation will change from a men's to a mixed tournament, and teams may bring up to 16 athletes if at least one is female.
This decision applies only to the Vancouver 2010 Paralympic Winter Games. The IPC will continue to explore other initiatives to further develop the sport world wide before the Sochi 2014 Paralympic Games.
Since its debut on the Paralympic programme at the Lillehammer 1994 Paralympics, ice sledge hockey has quickly become one of the largest attractions for spectators at the Paralympic Winter Games.

subset: commoncrawl


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Nate Shelter is a senior from Massachusetts, studying public communication and history.
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To celebrate the launch of The Swanton Hotel Grand Mercure's 'In The Know' Guides that unearth the hottest spots to discover, and to been seen in Melbourne, the hotel is giving you the chance to win your ultimate Melbourne weekend.
Simply logon to The Swanston Hotel's Facebook page www.facebook.com/theswanstonhotel, click on the left hand side 'win tab' and vote for your favourite weekend. Choose from four unique itineraries including Girls Weekend Away, a Romantic Escape, Culture Vultures Weekend or Foodies Weekend.
The prize includes a personally tailored weekend for two planned in consultation with the hotel's In The Know Concierge. You'll enjoy two night's accommodation with breakfast at The Swanston Hotel Grand Mercure, lunch and dinner for two daily at some of Melbourne's coolest restaurants and a selection of Melbourne's top activities and experiences.
Voting is open until midnight Tuesday, 31 January 2012. The winner will be drawn on Friday 3 February and will have two months to enjoy their ultimate Melbourne weekend.
Win the ultimate weekend in Melbourne with The Swanston Hotel
Source = The Swanton Hotel


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Lucy Battersby Google+
Lucy Battersby is Technology Reporter for Fairfax Media. She worked on communications policy for the federal government before joining Fairfax in 2006.
Critics attack plan to spend more on NBN advertising
Lucy Battersby Federal government to spend a further $15m advertising the National Broadband Network.
CSIRO brings broadband to your TV antenna
Lucy Battersby Wireless broadband could be delivered to regional households more reliably and at faster speeds if an emerging technology being developed by the CSIRO is used in the NBN.
Broadband rollout boost
Clancy Yeates and Lucy Battersby The NBN has cleared another hurdle, after Telstra and the NBN Co nailed down details of their $11 billion deal designed to lower the network's cost.
Price jolt on NBN access
Lucy Battersby Consumers will face higher prices to use the NBN than initially promised if the first retail prices released are an accurate guide.
NBN falls months behind schedule
Lucy Battersby Network rollout behind schedule because of delays in striking a deal with Telstra and issuing construction contracts.
New chief a cultured person who knows his business
Lucy Battersby News Ltd's new chief executive has a reputation as being a cultured man with a sharp intellect and an astute business sense.
NBN rollout favours Labor seats
Lucy Battersby Gillard government accused of exercising pro-Labor bias in the selection of new rollout sites.
Mainland launch for broadband network
Lucy Battersby The Prime Minister will officially launch the national broadband network in mainland Australia today - a month behind schedule and alongside one of the independent MPs who helped her party form...
A reputation at stake as Coalition seizes stick to beat NBN
Lucy Battersby A SEVEN-YEAR corruption investigation winding its way through the United States courts is haunting the head of NBN Co, who last week apologised for not knowing Costa Rica fell under his...
Telstra split clears way for the NBN
Lucy Battersby and Clancy Yeates FULL-SCALE rollout of the national broadband network will start within months, as telcos are already advertising prices from $30 a month for basic services and up to $165 for super-fast connections.
Labor pledges emergency texting
Lucy Battersby Deaf, hearing and speech-impaired people will soon be able to text emergency services from their mobile phones.
Telstra may halt copper lines, says Conroy
Lucy Battersby Telstra may stop laying copper to new housing estates and provide telephone services through wireless networks, Communications Minister Stephen Conroy says.
Call cost fixed at 22¢
Lucy Battersby The cost of local calls will be capped at 22¢ and calls from payphones capped at 50¢ until June 2012.


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Heitinga is main man in Manchester City programme.
It's an action-packed official matchday programme for the visit of league leaders Manchester City to Goodison on Tuesday night.
John Heitinga is the main interview for the second game in the space of five days, with the Dutchman reflecting on the season so far, his thoughts on Shane Duffy, and how the Blues need to go about the clash with City.
Elsewhere, Tony Grant recalls his time at both clubs, while there's all the action and reaction from the 2-1 win over Fulham in the FA Cup fourth round, with Denis Stracqualursi a particularly happy chappy after netting his first goal for the Blues.
We look back at some past fixtures with City, while David Moyes, Phil Neville and Ronnie Goodlass pen their regular programme notes and Match of the Day commentator Simon Brotherton gives his views in Press Box.
Jose Baxter looks back on his recent loan spell at Tranmere Rovers, while new arrival Darron Gibson takes his turn at Gimme 5ive as he picks his top tunes, destinations, places, players and some random favourites.
There's plenty more on offer for the date with Roberto Mancini's men, with a full round-up of all the latest Academy action, as well as all you need to know about Tuesday's opponents.
Tim Howard gives his thoughts on breaking a recent Everton record and there's the highlights of Colin Harvey's recent webchat on evertonfc.com.
Supporters of all ages can tackle the Spot the Difference puzzle as well as taking on the tricky Toffees quiz and we also look back at previous Everton fixtures played 'On This Day'.
The 84-page edition is priced £3 and will be available to purchase inside and outside the stadium, from the Everton One and Two megastore and sales points outside of Goodison and in Stanley Park car park.
Programmes can also be ordered by calling 0845 143 0001.
- Previous Article Behind Enemy Lines
- Next Article Blues Agree Jelavic Deal


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Light to medium bodied wines that are high in acid and light to medium fruit. Typically no oak.
Light to medium bodied wines with lots of juicy fruit, typically medium acid and medium oak.
Full bodied wines that have typically undergone malo-lactic fermentation and/or spent time in oak.
Chateau de Fontenille Entre Deux Mers Blanc is a simple white, with a lot of lime and celery character. Medium bodied, with a light finish. It is a very aromatic wine, which highlights the characteristics of sauvignon of muscadelle and sauvignon gris.
Château de Fontenille is located very near the Abbey of La Sauve Majeure on gravel land bathed in generous sun. In the 4th century when the poet Ausone was praising the wines of the region, there was a villa at the nearby called "Font e Melha" of which some ruins still remain today.
The vineyards cover 42 hectares, 30 of which are red and 12 are white grapes. The soils are clay and limestone with some gravel. The wines are vinified traditionally with controlled tempratures and aged in 50% new oak for the reds.
A few extra appellations: Bourg & Blaye These two appellations are just across the Gironde river from the Haut-Medoc - a bit northwest of St-Émilion and its satellites. Bourg is the smaller appellation, nestled under the much bigger Blaye. Both have AC status, Cotes de Bourg AC and Cotes de Blaye AC. One step up on the AOC chain is the Premieres Cotes de Blaye AC, producing...Read More About Other Bordeaux
Bordeaux White Blend There's white wine in Bordeaux, too! Typically made from Semillon, Sauvignon Blanc, and bits of Muscadelle, white Bordeaux can be a fully dry table wine or, as in Sauternes, a deliciously sweet dessert wine. In other areas of the world, a Bordeaux blend consists primarily of Sauvignon Blanc and Semillon, either of which may be the predominant variety. Bordeaux blends can vary in style, but most have good acidity and often a mineral overtone.
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2.0.0 RC3 (last update on Jan 16, 2014)
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what i hate that its using external library and too many files installed silently. Namely koowa,nookue framework,its plugins, com_docman,com_files , Duh not for me. thanks
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The foursome will be heading to Auckland for a one-off show at the Powerstation, Eden Terrace on 29 March.
The band has been busy writing and recording new material to feature on their fifth album, Save Rock and Roll.
Led by bassist Pete Wentz and fronted by Patrick Stump, the group unofficially split in 2009 after releasing their greatest hits album.
It looks as though the band have turned over a new leaf, with Wentz committed to making "some music that matters to us".
They released new music last month with a heartfelt message, "When we were kids the only thing that got us through most days was music. It's why we started Fall Out Boy in the first place. This isn't a reunion because we never broke up. We needed to plug back in and make some music that matters to us. The future of Fall Out Boy starts now. Save rock and roll...".
Fall Out Boy are heading our way ahead of the release of their latest album Save Rock and Roll, which comes out in New Zealand on 15th April.
Fall Out Boy tickets are available through Ticketmaster.
View slideshow: How much would it cost to book your favourite band?


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text:
These colorful foam cylinders, available in many sizes, work great for everything from saltwater popper bodies to hoppers and extended-body mayflies.
Smaller sizes (3/32 and smaller) come ten to a pack and are a little over an inch long. 1/4 and 3/8 inch diameter cylinders come six to a pack and are 1 1/2 inches in length. 1/2 inch and larger diameter cylinders come four to a pack and are also 1 1/2 inches in length.
Click on the "Color Chart" link below to see samples of available colors. The chart will open in a popup window.Color Chart


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An Easley High School teacher was arrested Thursday after police said he had sex with a student.
Liberty police said 31-year-old John Kilgallen was charged with sexual battery with a student after an investigation revealed he had a sexual encounter with a 17-year-old female student.
A spokesman for the Pickens County School District said Kilgallen was placed on administrative leave on Tuesday after the girl's parents told school officials about the relationship.
Kilgallen resigned before his arrest on Thursday, according to a school spokesman.
Kilgallen had taught science at Easley High School for several years.
Copyright 2012 FOX Carolina (Meredith Corporation). All rights reserved.


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Sermon Search Results for The Flood
Free Sermons and Sermon Outlines for Preaching
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Results: 88 Sermons
There's an old saying "God hates the sin, but loves the sinner." But the Bible actually tells me God hates sinners. How can that be?
Series: A Word To The Wise
Scripture: Proverbs 6:16-6:19
Tags: Repent, Cycle, Wicked Ways, Destruction, Transgression, [more]
Shared: 6/9/2013
How do I "sign up" for God's Army?
Scripture: Ephesians 2:1-2:10
Shared: 10/11/2009
Everyone has bad days. Everyone stumbles. Even the best of us fail. What will you do?
Series: Flood Plain
Contributor: Timothy Darling (84 sermons shared)
Denomination: Mennonite
Scripture: Galatians 6:7-6:10
Tags: Endurance
Shared: 2/9/2008
The people of that day were unbelievably wicked, but was there a chance God would have spared them? Did God want to? And what can the flood tells us about the coming judgment at the end of time when Jesus returns?
Series: The Beginning and The End
Scripture: Genesis 6:5-6:13
Shared: 4/27/2014
The true story of Noah teaches us something about the justice and mercy of God, and how His grace can save us from His wrath.
Contributor: Chris Jordan (389 sermons shared)
Denomination: Foursquare
Scripture: Genesis 6:1-9:13
Shared: 4/17/2014
Some new year necessities.
Contributor: Steve Shepherd (715 sermons shared)
Scripture: Romans 12:9-12:11
Tags: New Year's Day, Noah Flood
Shared: 1/5/2004
Why does Genesis tell us about Noah sending out a Raven and a Dove to see if the waters had receded from the face of the earth? Why bother? They're just a couple of insignificant birds... or are they?
Series: Animal Parade
Scripture: Genesis 8:3-8:17
Shared: 7/25/2011
This is a 1st person re-enactment. It tells the story of the flood from a grandfatherly, though gruff Noah's perspective.
Scripture: Genesis 6:1-9:17
Tags: First, Flood, First Person, Noah, Person
Shared: 2/7/2001
What we learn by going through trials and testings.
Contributor: Ronnie Thrower (46 sermons shared)
Denomination: Baptist
Scripture: Isaiah 43:2
Tags: Flood, Knowing God's Will
Shared: 6/1/2001
Evolution Series, part of Dates, Deluge and Dinosaurs. Proofs of the flood, including proofs from Dec. 26, '04. Powerpoints/notes for entire series at website.
Contributor: Jerry Shirley (652 sermons shared)
Denomination: Baptist
Scripture: Genesis 1:1-9:1
Tags: Noah
Shared: 1/7/2005


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text: Hilltop Lake is a lagoon in Richmond, California. The lake is fed by Garrity Creek, a small river originating from many springs in the hills east of the Hilltop Green neighborhood in the Hilltop neighborhood. The pond is located within Hilltop Lake Park and is very close to Hilltop Mall. The lake is in the middle of the flow of the creek and the water flows to the marshlands and shoreline of San Pablo Bay. The water body is sometimes confused with Temporary Pond however this lagoon lays to the northwest and is fed by a different watershed entirely.


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Waterview - Local Information, Resources & Photos
Waterview - Searchable Map, Aerial Photos & Driving Directions
Waterview is a community or populated place (Class Code U5) located in Wicomico County at latitude 38.2471 and longitude -75.903. (Waterview Panoramio Photos). The elevation is 7 feet. Waterview appears on the Deal Island U.S. Geological Survey Map. Wicomico County is in the Eastern time zone (GMT -5). Observes DST? Yes. Current Time. | Nanticoke, MD ZIP Code Maps | Waterview local area photos
Photos of the Waterview Local Area
Waterview had a population of 0; a land area of 0.49 sq. miles; a water area of 0.01 sq. miles; and a population density of 0.00 people per sq. mile according to the US Census Bureaue estimate of July 1, 2009. Latest Census Estimates for all incorporated places in Maryland.
Wicomico County: Cities & Towns | ZIP Codes | Schools | Features (airports, churches, hospitals, etc.)
Waterview Local Resources
Waterview Arts & Culture
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Waterview Pets & Hobbies
Waterview Schools & Education
Waterview Social Services
Waterview Travel & Tourism


text:
Someday I will have something interesting to write here, but for now...
Catching Elephant is a theme by Andy Taylor
I love this movie. Is one of the most terrifying movies I've ever seen.
Rec inspired Quarantine , but Rec is way, way better! Even for me! A girl from Spain who doesn't like the spanish movies.


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Affordable Properties Pune
Pune's Dhanori offers affordable properties
Pune's Dhanori is an upcoming area situated on the eastern side of the city and offers properties at competitive prices compared to other areas. Huge scope of development in the area is fuelling the housing demand. The availability of land is increasingly attracting developers to this area. The area now offers several affordable new housing projects, which are at various stages of construction.
Moshi in Pune offers high appreciation on realty
Are you looking to invest in a property that offers you high annual capital appreciation? Moshi, in Pune, placed in the heart of Pimpri-Chinchwad Municipal Corporation (PCMC) area, has caught the eye of real estate investors in the city owing to its affordable rates.


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الانتفاضة الإلكترونية
Photography series tells some of the individual stories of Palestinians in Gaza from the 51 days of Israeli bombing and terror.. MORE
PHOTOS: Anne Paq/ActiveStills
It cannot be mere coincidence that the University of Illinois' heavy-handed action targeted a Palestinian-American scholar and an American Indian Studies program.
"Now, our battle to hold Israel accountable for its fresh war crimes and crimes against humanity has begun," say Palestinians in Gaza.
University boss Phyllis Wise sits on the board of Nike, a firm that does business with West Bank settlement firms
Photography series honors the extraordinary solidarity and heroism during Israel's bombing.
A monthly roundup of photographs documenting Palestine, Palestinian life, politics and culture, and international solidarity with Palestine.
Professor Ahmad Qatamesh spent almost nine years in Israeli prison without trial.
Family of Muhammad Sinokrot vigorously refuse Israel's version of events.
Maisan Hamdan, an organizer with a military refusal group, on the rise in conscientious objection.
The Israeli author and academic lives in what he describes as "one of the most racist societies in the Western world."
Your support helps us tell Palestine's stories every day. Donate Now
© 2000-2014 electronicIntifada.net


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At a time when the public image of boxing was being thoroughly dragged through the mud, following their WBO world light-heavyweight title fight Nathan Cleverly and Tommy Karpency reminded many that respect is the fundamental element of the sport.
In the post-fight press conference both were keen to praise their opponent, an all too often rarity in other sports. Cleverly opened, I think Tommy showed tonight why hes sparred world class fighters. Hes very tough, he knows his way around the ring and hes very relaxed. Hes got good power and hes a tough fighter.
So, it shows that at world level you cant take anyone for granted and Tommy showed that tonight, he was very tough, if I take my eye off the game then someone like Tommy can punish me. Its important that I kept my eye on the game and at this level its crucial. he continued.
He was probably the toughest to fight over the 12 round distance. Theres a lot of fighters that are tough over the first 6 rounds, into the championship rounds they wilt, they go and fold. Tommy showed that hes a 12 round fighter and at world level thats the difference.
Even though he was the away fighter, Karpency earned the admiration of the Welsh fight fans with his refreshingly respectful approach pre and post fight The American was grateful and commented, Ive travelled a few different places and Ive been absolutely well received here. I actually enjoyed walking to the ring to hear the Welsh crowd cheering for Nathan, its a great experience and Id love to come back here and fight again.
He added, Its a great fight community here, the fans are into the fight and they also seem to be knowledgeable as well. They have a great champion, I was highly impressed by Nathan as well, its been a great experience all around.
Despite not being given a round by any of the 3 judges, Karpency wasnt bitter and he backs his conqueror to compete with the absolute elite of the division.
Karpency said, No fighter I have been in with could walk over Nathan. After being in the ring with him for 12 rounds I believe that he could fight with anybody in the world.
Hes in top condition and he keeps a high work rate, he takes a good shot, I hit him with some good shots, he sucked them up when a lot of my shots have put guys down.
I think he can compete with the likes of anybody in the world, I think he would make a good fight for Hopkins or Dawson right now. Hes ready for anyone
In front of a sell-out crowd of 5,000, it was Cleverlys first fight in Wales for 4 years. He last boxed in Wales on the undercard of Joe Calzaghes super-middleweight unification with Mikkel Kessler at the Millennium Stadium in front of 55,000 fans.
Thankful for the support he received on Saturday, Cleverly said, Regardless of the opponent tonight, it was the homecoming! That was what it was about for me - returning home after 4 years since weve had world title boxing in Wales.
The timing was absolutely spot on tonight to return home as world champion, the fans had value for their money tonight; it went the full distance so well done to Tommy on that.
Tommy came up to me in the end and said Im capable of beating any opponent in the world, that was a great compliment from my opponent.
Warren eyes a boxing return to the Royal Albert Hall headlined by Cleverly
Promoter Frank Warren says that Nathan Cleverly could defending his WBO world light-heavyweight title for the 4th time as boxing returns to Londons legendary Royal Albert Hall on April 28th.
It would be the first time boxing has been held at the venue this century, the last bout there was between Julius Francis and Danny Williams for the British and Commonwealth heavyweight titles in 1999.
Speaking at the post fight press conference following Cleverlys shut-out victory over Tommy Karpency on his homecoming to Wales, Warren believes that Cleverly is the best man to take boxing back to the Royal Albert Hall.
He said, There has been no professional boxing there for many, many years, it is probably the best venue in the country, the most prestigious venue. You could not get a better name and a better representative for British boxing than Nathan, to showcase professional boxing back there but well sort that out in 1 or 2 days.
Adding, I don't know if Nathan will be ready for that but I would not mind him being the guy to take boxing back there.
If Cleverly was to fight on April 28th, it would coincide with Bernard Hopkins rematch with Chad Dawson in defence of his WBC world light-heavyweight title and Warren hinted of a more direct link between Cleverly and the big name Americans.
Nathan is coming on in leaps and bounds and all our attention will now of course turn to April 28 and the Bernard Hopkins V Chad Dawson fight, then we will be making a big decision about a fight in the summer. commented Warren.
'Nathan needs big fights, he rises to them and he has a fabulous temperament.
On being asked about the possibility, Cleverly seems keen to stay busy. He said, Ill be fine for April, Ill be good. I can keep active and it wont hurt as well, a few more fights as world champion to gain experience as world champion is good.
Although no opponent is certain, Cleverly knows what he wants. He said, Its important that as world champion we get good quality fights, a world ranked opponent to keep my progression going as world champion ready for the step up to the unification fights.
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Glamorgan have signed Australian left-arm seam bowler Dirk Nannes for their 2013 Twenty20 campaign.
Twenty20 specialist Nannes, 36, joins following a stint at Sylhet in Bangladesh's Premier League.
He has played 15 times for Australia's T20 team and will be Glamorgan's second overseas player in the competition.
Nannes joins fellow Australian Marcus North as an overseas player, with the latter also leading Glamorgan in the T20 and 40-over competitions.
The county's latest signing provides an added option of a strike bowler towards the end of an innings. Read more
Courtesy : www.bbc.co.uk


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Stanley Tucci is an American for Marriage Equality
May 2, 2012 by Charlie Joughin
Acclaimed Actor Joins HRC's Campaign for Marriage NationwideContinue Reading ►
NC Sen.'s Wife Allegedly Claims Amendment One would "Protect Caucasian Race"
May 2, 2012 by Eric Cameron
Several poll workers in Winston-Salem are reporting that the wife of NC Sen. Peter Brunstetter remarked yesterday that her husband sponsored Amendment One in an effort "to protect the Caucasian race."Continue Reading ►
Mitt's Gay Spokesman Resigns; Bryan Fischer Celebrates
May 1, 2012 by Dan Rafter
Richard Grennell steps down as Romney spokesperson following outcry from anti-gay extremists.Continue Reading ►
HRC Teams Up with Allies in NC Phone Bank
May 1, 2012 by Guest contributor
We are really putting in an amazing effort to defeat Amendment One across North Carolina.Continue Reading ►
May is National Foster Care Month
May 1, 2012 by Paul Guequierre
Did you know there are over 400,000 children in the foster care system in this country? These are kids who need someone to send them off to school in the morning, help them with their homework, hug them, and simply provide a loving home. We often talk about adoption and the barriers LGBT families face, but we rarely focus on foster care. May is National Foster Care Month. The occasion gives us an opportunity to reflect on the experiences and needs of the children and youth in the foster care system.Continue Reading ►
Top Posts
Speaking at Southern Comfort 2014
September 5, 2014
Federal Judge Strikes Down Florida's Ban on Marriage Equality
August 21, 2014
Take a Look: Updates, Photos and Audio from the Seventh Circuit's Marriage Equality Cases Today
August 26, 2014
Seventh Circuit Rules Bans on Marriage Equality Unconstitutional
September 4, 2014


text: Quick View Waiting For Baby by Harriet Ziefert March 26, 1999 | Picture Books Out of stock used copies from $5.04 Max does everything he can think of to encourage his new sibling to be born. He talks to his mommy''s tummy, sings to it, plays his drum for it, but nothing seems to work. Max is convinced that this baby will never arrive ... until the day finally comes when Daddy takes Mommy to the hospital.… See Details $19.99 / $18.99 lowest price*, or used from $5.04was


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- timber maniac
- Balamb Garden
- Canada
This conversation is closed.
Which video game has challenged your perspective on the way you live your life and how?
The video game I credit is a role playing game called Final Fantasy 7.
The conflict of the game begins immediately. As you play the story unfolds and you learn of a corporation that is extracting 'Mako Energy' from the planet by means of giant reactors. This 'Mako Energy' is then converted into electricity that is used in the city surrounding the reactors. It is a lucrative business. As a player, you begin the game with your character being directly involved in a vigilante terrorist group; a group whose goal is to destroy these 'Mako Reactors'.
Though the character you play cares little for the goals of his group (your character's main interest is making money), you continue to be involved in these vigilante missions. As time progresses in the game (meaning you complete more story-line) your character learns that 'Mako Energy' is found in all of the creatures and plants that inhabit the game's world. When a life ends this 'Mako Energy' flows back into the planet. It is then recycled by the planet and used to create new life. You understand that the extraction of 'Mako Energy' will result in the disabling of the planet's ability to support new life, and it also means that the planet is itself a living thing (as a player you can visit a place in the game and hear the planet itself making painful noises). You learn that the corporation's president is aware of these facts and is yet still planning to progress with the extraction of 'Mako Energy'.
How did this challenge my perspective?
Growing up I had been exposed to many different ideas of accountability but only at the age of 12, with the help of this compelling story, did I seriously contemplate my role in society. I wondered what kind of character I was, and what kind of character I would like to be. The story made it clear that those who act from a source of greed were ostracized from a moral society. I decided that indifference towards suffering cannot be hidden and that greed will never be satisfied.
Showing single comment thread. View the full conversation.
Lilian Chen 50+Jan 30 2012: Super Smash Brothers Melee.
Two aspects of this game have altered my life drastically: the community and the gameplay.
SSBM has now been released for ten years, meaning that it has no internet capabilities. In order to play, one needs to physically leave their rooms and go out and find others to play. As a result, we've managed to build a community consisting of hundreds of players, some residing in the U.S. while others in Europe and Asia. The competitive scene began around 2002, when tournaments began being hosted, and to this day, our community still thrives off these tournaments.
I cannot stress enough the amount of close friends and relationships I've found and formed through this community alone. It's unbelievable to imagine that a single video game could alter my life this much. Without Super Smash Brothers, I would be short some of the closest relationships I've made to this day. It's astounding what can come out of a relatively underground social clique held together by the mutual interest of a video game. While the community has both its ups and downs, I would still bet that the community alone is what keeps our players playing ten years later.
Showing single comment thread. View the full conversation.


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- Sep 20:
- Few fireworks in first Texas governor's debate
- Sep 1:
- Wendy Davis makes campaign stop in El Paso, promises to fight for average Texans
- Aug 5:
- Claudia Ordaz has first City Council meeting as District 6 representative
- Jul 20:
- Claudia Ordaz elected as new representative for El Paso City Council District 6
- Jun 23:
- El Paso City Council race: Ordaz leads in District 6 campaign fundraising
- Jun 15:
- Texas elections: A big shakeup in Davis camp as gubernatorial hopefuls prepare
- Texas Tribune: In CD-23, Advantages Are Seen for Both Gallego and Hurd
- May 27:
- County Commissioner elections: Stout defeats Lewis in runoff
- Norma Chavez concedes to Cesar Blanco in District 76 runoff election
- County Clerk Delia Briones surges ahead of former employee Valerie Sanchez
AUSTIN >> A day after news of her 2013 bankruptcy broke, Lyda Ness-Garcia on Wednesday released a public letter blasting a political opponent, claiming she had attacked her family.
Ness-Garcia, who is challenging state Rep. Marisa Márquez in the March 4 Democratic Primary in District 77, excoriated Márquez for allegedly continuing "to attack my character and attack my family."
"The working men and women of our district deserve better than your pitiful personal attacks," the letter said. "And they deserve better than your failed record of siding with Republican campaign contributors against our schools, our veterans, and women's health care."
Márquez responded that she had never said anything about Ness' family and she accused Ness of misrepresenting her record.
"She's spoken about my record," Márquez said. "It's only fair that we speak about hers."
Márquez was referring to Ness-Garcia's bankruptcy, which was finalized on April 8, 2013.
It details more than $200,000 in federal income-tax liens, which were settled last year and more than $4,000 in state ethics fines, which were settled in the past two months.
"Public trust is critical to what we do," Márquez said on candidates for public office.
On Tuesday, Ness-Garcia said she had not previously described the circumstances that led to her bankruptcy out of a desire to protect her children. She laid them out in her Wednesday letter to Marquez.
She said that she was in debt from a unsuccessful 2008 run for judge, her marriage had fallen apart and she had been diagnosed with cervical cancer.
"Back in 2008 I was worried for my health and worried for my children," the letter said.
"I had already seen my marriage fall apart due to a terrible betrayal by my ex-husband.
However, like countless El Paso families who face hard times, I persevered and with outstanding medical care, I beat it, and discovered how strong I was."
Primary runoff election: May 27
›› Election section
›› Early and mobile voting
›› Sample ballots
›› Polling places
›› Editorial Board endorsements
Ness-Garcia's bankruptcy filing lists less than $10,000 in medical expenses.
The biggest liabilities she listed were almost $200,000 in student loans, $269,000 she owed on her house, $275,000 she owed to the IRS and $100,000 she owed to a collection agency.
In a meeting with the El Paso Times editorial board, Ness-Garcia said the settlement of her tax liens is the consequence of her bankruptcy and negotiations with the IRS.
"They basically told me I had to fulfill a very small obligation, actually, and then they made me pay installments for about a year and helped me resolve it that way and they lifted the liens."
Asked if her bankruptcy was largely the vehicle through which she settled her IRS obligations, Ness-Garcia said, "In part negotiation, in part bankruptcy."
In an interview Wednesday, Ness-Garcia said her illness was partly to blame for her bankruptcy but it didn't list many medical bills because she had a good medical policy — one that cost her a lot of money in premiums because she is a lawyer with a practice without partners.
She said her illness made her lose income by forcing her to miss work.
Márquez' campaign released figures saying the county paid Ness-Garcia $58,172 for legal services in 2009 and $47,561 in 2010. Ness-Garcia, who practices family law, handles some child-protective services cases for the county.
She said those figures were far below what she would earn in a normal year and were inadequate to defray the overhead for her office.
"I usually make close to $80,000 or $90,000," she said of her work for the county.
Income figures listed on her bankruptcy say she earned $103,000 in 2010, $82,000 in 2011 and $53,000 in 2012 before she filed for bankruptcy on Dec. 4.
The filing said her gross monthly income was $5,722, or $69,000 a year.
Ness-Garcia was asked how much she earned in 2008 and 2009.
"I don't have those records," she said.
Márquez said she particularly objected to a passage in Ness-Garcia's letter that accused her of voting for "a Republican version of the state budget which kept billions of dollars in cuts to public education "
Márquez said that she and other Democrats on the House Appropriations Committee fought hard last year to replace $3.3 billion of the $5.4 billion in funding for public education that was cut in 2011.
Márquez noted that five of six members of the El Paso delegation — all of whom are Democrats — voted for the same budget.


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Hey Brainiacs, I hope you enjoyed the last post on PPC 101. Today's topic is about keyword selection for PPC which was originally presented by Mr Guy Wayland from e-Channel Search.
Plan first
Source: libguides.umhb.edu
It's important to plan your campaign first as the structure of the campaign is dependent upon:
1. Your business view – what do you want to achieve from the campaign? Conversions, branding etc.
2. The searcher's view – Find out what they are really searching for.
Fig.1 – The intent of the business and searcher
Source: e-channel.com.au
Fig.2 Types of keywords in accordance to commitment level
Source: e-channel.com.au
Think about what you want to achieve in the campaign and plan your goals accordingly.
Two sources of relevance
Consumer Relevance – is how your product or service meets the customer's needs or search intent. Basically, the keyword must match the Ad and the landing page must match the keyword. Consumers won't be worried about the price as much if it is what they are looking for.
Relational Relevance – This relates to how the Ad creative matches the matter/keyword.
Quality score
The (QS) Quality score/Quality index is basically a means to which a search engine uses to measure determine the actual CPC (Cost-Per-Click). Basically it measures the relevancy between three elements, the given Ad, the keyword, and the target landing page.
Factors that determine Quality Score:
- Keyword relevance
- Ad relevance
- Landing page relevance
- Click Through Rate (CTR)
- History
Keyword selection is just one part of the equation if you wish to reach the right audience as you also need to focus on your Ad placement to reach the right customers. The are two parts of prospecting:
1. Keyword research
- Which needs to have Head terms (broad) and Long-tail (deep).
- Be mindful of Quality Score at all times or you will be wasting your money.
- Make sure you use negative keywords (think about what your won't be searching for)
- Use Geographical targeting – do it extensively.
- Tailor your content network and eliminate the places where you don't want your Ad to appear on.
2. Finding the motivation behind their search
Source: ehow.com
If you don't make the offer clear on the intent you will lose them so it is important to know what motivates them in the first place. Think about your potential customers, what they are like, what characteristics they have etc.
Fig.3 - Know your customer
Source: e-channel.com.au
There are three elements your Ad should have:
1. Star – Your headline should capture their attention and get them pause long enough to look at your Ad. Here you need to focus on the keyword that you can build into an attention-grabbing headline. The headlines are more important the body copy.
2. Chain – A series of facts that will convert their attention to sustained interest i.e they read your Ad. Here you need to find out why they are using that particular keyword.
3. Hook – Something that will convert their sustained interest into an action which gets them click on your ad. People will see numbers clearer than words (50% off is more eye-catching than half-price). Hook them in by trying to create a sense of urgency.
Top tips
- Test the keywords on a different campaign.
- It's important to understand how they are searching.
- Make it your aim to fulfill their need or search query.
- Put a guarantee on your ad as it will reinforce the ad.
- Grab their attention as people don't always click on the first one, they click on the ad that grabs their attention.
- Keep it short and sweet – keep the keywords minimal.
- Remember that it's better to have more Ads with less keywords than less ads with more keywords.
Well that concludes this topic, the next post will about Writing and Testing Ad Copy. If you like this post then stay tuned by following us on twitter. Until next time, this is +Jahn Sapanlay signing out.


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Verona (WQOW/WKOW) - It's not often you can start off the month of December by teeing off.
Some golf courses in the
southeastern part of the state actually reopened this weekend. This is video
from Hawks Landing in Verona.
The head pro there says local golfers have responded to the warmer weather.
"It's a big bonus, cause
the course is in such good shape and the price is right. But I think they're,
more than anything, just happy to get out," says Rich Bartley, the PGA Head Professional at
Hawks Landing.
Hawk's Landing
says it will be open a few more days.


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The Green Party is an independent party based on Ten Key Values, one of which is "future focus." America can't be turned into a multi-party democracy overnight. But it's a necessary reform towards solving the real problems we face.
Unlike all other political parties in the US, all our policies and endorsements are decided by our grassroots activists, not from the top down by elected officials. In the SF Green Party, anybody who spends an afternoon registering Greens at a street fair has a direct and equal voice in our decisions. It's easy to get involved and make a difference!
To become a member of the Green Party, you can register online from any county in California. As of September 2012, everything can be done securely online without mailing in any paper!
If you'd like to become more active in the party, just look for volunteer opportunities on our website. Or stop in at a meeting and meet us--all our meetings are open to the public, and new members are welcome! We meet on the 4th Wednesdays of every month at various locations around the City (generally announced here about a week in advance). Meetings and events are also announced in our newsletter.


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Sign up for Yardbarker's daily Top 10 newsletter, the Morning Bark! Customize to get news on your favorite sports and teams.
Found January 21, 2013 on San Francisco Giants Baseball (SF Giants...:
PLAYERS: Brian Wilson, Buster Posey, Hunter Pence, Jose Mijares, Gregor Blanco, Sergio Romo, Joaquin Arias, Brian Sabean, Bill James
TEAMS: San Francisco Giants
TEAMS: San Francisco Giants
Let's get everyone all caught up to speed with the San Francisco Giants and their arbitration eligible players. On Friday, the Giants hammered out deals with four of their six arbitration eligible players. The following four players have agreed to terms and avoid arbitration are catcher Buster Posey ($8 million), outfielder Hunter Pence ($13.8 million), reliever Jose Mijares ($1.8 million), and outfielder Gregor Blanco ($1.35 million). That leaves two players that are going through the arbitration process. That's closer Sergio Romo, and infielder Joaquin Arias. Jon Heyman of CBSSports.com reports (via Twitter) that Romo filed for $4.5 million, and the Giants were at $2.675 million. I haven't heard any figures for Arias at this time. Anthony Sulla-Heffinger of the New York Post breaks the story over the weekend that closer Brian Wilson's tenure in San Francisco is likely at the end. "I'm going to be brutally honest as I always am, I don't [think Wilson will return]," says GM Brian Sa...
Original Story: http://www.sfgiantsbaseball.net/sf-gi...
Comments are closed.
What do you think?To leave a comment, you can:
Brian Wilson Will Not Return to Giants
The Year of San Francisco
Giants, Posey not rushing new deal
VIDEO: In the Ring with Hector Sanchez Interview with Ray Ximenez
Sergio Romo Backstage at Raw, David Otunga Talking Murder Trial, Yoshi Tatsu on TV More?
VIDEO: In the Ring with Hector Sanchez Interview with Alex Clarkson
Wilson doubtful to return to Giants
Brian Wilson is a free agent and the Giants do no expected to have him back. Wilson has spent his entire career with the Giants.
David Otunga Talking Murder Trial Today, MLB Star Backstage at RAW, Yoshi Tatsu News
MLB Star Backstage at RAW, Yoshi Tatsu on TV More?, Otunga Law Really Happening Today
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- Detail Images
Think big.
Taking a test naked is a common nightmare. But riding naked on a blisteringly hot day is a fantasy for cyclists. Hincapie takes a serious stab at making that goal a reality with their Power Bib Shorts.
No this isn't an 'emperor's new clothes' joke. No, the shorts are not see through. They are, however, extremely cool and comfortable. The cool comes from the application of Schoeller's ColdBlack treatment to the black panels. This invisible finish reflects the sun's heat away from the body for greater comfort and insures that the shorts provide SPF 50 protection.
Adding to the cool comfort is the fact that these shorts, once on, stay in place. Hincapie has deployed AT2 Force Power Lycra for a firm but gentle squeeze of your legs. This means not only that the chamois won't move, but you'll experience fewer jarring vibrations when riding. And thinking that everyone wants shorts that last for years, Hincapie places ABR Resistor Lycra in areas where the shorts come in contact with the saddle. For the bibs, VelociTek Mesh is used thanks to its great stretch, super-fine mesh, and excellent wicking. Instead of grippers at the bottom, the legs have a double layer of spandex leg bands, which hold well without biting into the skin.
The chamois is Hincapie's Anatomical Power Chamois, a multi-density stretch pad with high-density foam added to the sit bone areas.
The Hincapie Power Bib Shorts have reflective accents on the backs of the legs. The color is Black. Sizes run from Small to XX-Large.
Share your thoughts
What do you think of the
Hincapie Sportswear Power Bib Shorts - Men's
? Share a...
Comfortable. Great Chamois. Legs Ride Up
Matt Dunmore
Member since
- Gender: Male
- Familiarity: I've used it several times
- Fit: True to size
These bibs are very comfortable. The chamois is great. However, they don't stay put on your legs. They really need some non slip on the leg openings. The straps hit me a farther out on the shoulders than I am used to but not uncomfortable.
Bottom line: I probably wouldn't buy them again but I like them enough to keep them.


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Welcome to ANNAPOLIS POOL AND SPA
Come to Annapolis Pool and Spa service for residential and commercial pool, spa, hot tub service, maintenance, and repairs. With a combined 40 years of experience in pool construction and service, our family owned and operated company, knows how to provide detailed personalized service on all brands of pool and spa equipment, as well as all brands of hot tubs. We also design and install custom spas!
Swimming pools are a big investment and can be a wonderful oasis for your home when properly maintained. Do you give your pool the attention it needs every week like the professionals at ANNAPOLIS POOL AND SPA SERVICE? Our service technicians have been trained to provide you with the best service possible and have the knowledge to troubleshoot most situations that may arise with your system.
Visit our showroom, we offer a full line of pool and spa chemicals, maintenance equipment, parts, equipment, toys and supplies. We also offer Free in-store computerized water analysis.
We are the chosen warranty station for ALL major manufactures of swimming pool, spa and hot tub equipment. We service Pentair, Sta-rite, Goldline, Hayward, Jandy, Zodiac, Polaris, Balboa, Gecko, Raypak, Waterway, Intermatic, Smartpool, Paramount, Caretaker, Loop-loc, Merlin, Meyco, Anchor, BioGuard
To schedule service or request a quote, you can contact us at (410-266-1464), or click here
Winter SHOWROOM Hours of Operation
Monday – Friday 9:30-3:30
1811 McGuckian Street
Annapolis, MD 21401
(410) 266-1464
(410) 266-1465 Fax
Hot tub showings after hours by appointment.
We will gladly service your Swimming pool, spa or hot tub in the following areas: Anne Arundel County, Baltimore County, Howard County, Prince Georges County, Calvert County, Charles County, St. Mary's County, Kent County, Queen Annes County, Talbot County


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Sydney FC's buildup to tomorrow night's A-League elimination final against the Phoenix in Wellington has been dented after sending goalkeeper Liam Reddy home for an alcohol breach.
Reddy has been ordered back to Australia after it become clear he had been drinking alcohol on the team's flight to the Capital last night.
He'll be served a breach notice under the A-League disciplinary procedure and is unlikely to figure in the rest of the finals series.
Reddy is the side's back up keeper and previously spent a season at the Wellington Phoenix in 2009.


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Related posts:
Flying Over Hindukush Mountains
{ 6 comments… read them below or add one }
- May 31, 2009 at 10:19 am
Manish, I have better shots of the mountains I wonder why I posted this one Otherwise pictures come good while ascent or descent else as you say, it is all blue.Thanks Julia. I was back Vamsee on May 14th but went off to trek and I am back today (31 May). Thanks Sidhu.
- May 26, 2009 at 4:21 pm
- May 20, 2009 at 4:14 pm
Nice!! Are you back in India?
- May 20, 2009 at 11:34 am
out of the world Mridula
- May 20, 2009 at 7:29 am
But in case of mountain peaks results are different as seen in this pic too.
- May 20, 2009 at 7:27 am
I have taken many such pictures but all u see is the cloud cover the actual detailed topography of ground is difficult to capture from normal digicam
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Capture the moment and it will stay with you forever — that's exactly what we did at Coachella. We gave a selected few the opportunity to document Coachella through their very own eyes for our blog! It was lovely going through the photos and soaking ourselves through their experience and happiness — you can almost (…) Read more »
Tagged: photos - 2/36 - Free People Blog
We met at Coachella and…May 05, 2012
Smoke on the WaterApr 27, 2012
What happens when you put two insanely talented and beautiful women together? This shoot…featuring the designer behind Heyoka Leather – Leslie Crow — and shot by photographer Alexandra Valenti (who shot our July '11 book). I can't stop looking at these images — they are works of art! (…) Read more »
Inspiration: Surf Photography by Jeff DivineApr 25, 2012
This vintage surf photography by Jeff Divine is unreal! He truly has a gift for capturing the colors and the grittiness of the surf lifestyle back in the 70s when it was really picking up… (…) Read more »
Over The RainbowMar 30, 2012
A special Friday edition of office space for ya… happy weekend!!! (…) Read more »
Blogger Diary: OuttakesMar 26, 2012
The last couple of weeks have been a wonderful blur… from Woodstock and the Midnight Ramble, Big Pink and Overlook Mountain to SXSW and the FP Heart Strings tour. It's hard to pick a memorable moment when all of them are just that… (…) Read more »
March Moodboard & MixMar 02, 2012
I'm so happy it's March… December through February is my least favorite time of year, and I always greet March with a renewed energy and excitement for things to come – this month I have some traveling and several awesome shows to look forward to, which I'll be sure to tell you all about in (…) Read more »
the lovers the dreamers and meFeb 14, 2012
click on images for sources. (…) Read more »
Blogger Love: Meet Gemma of Fade to BlackFeb 09, 2012
I first discovered Gemma's blog Fade to Black over a year ago, and fell instantly in love with her style and everything she posts. We've emailed each other frequently, but finally the other day we got to meet in person when she came down to our office, or as she calls it, fairy land, for (…) Read more »
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Blogger Diary: Memory LaneJan 24, 2012
As you guys may have heard by now, we are opening our very first Free People store in Philadelphia this Friday! It is definitely a homecoming of sorts, as we open our doors on Walnut Street in Center City, not far from where the company began. You'll hear much more about all the special touches (…) Read more »
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Have a wonderful weekend! click on images for sources. (…) Read more »
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When I was little I always wanted a white Christmas… well, it's 60 degrees and sunny in Philly today – but I am not complaining, not at all. Happy holidays! click on images for sources. (…) Read more »


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Overall Rating:
Exceptional Quality
Beautiful product. Sturdy construction. Slats are substantial. The drip tray is weighted as well so there is no tipping. I have many full size umbrellas in it and it is very stable. I almost bought the brown, material covered one because it is taller, and the review said it was heavy. I am glad I took a chance on the bamboo because it is very...Read the full review >
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Michael Burks
BiographyArkansas blues artist Michael Burks plays guitar with a stinging vibrato and an aggressive tone, sounding like a combination of Freddy King and Otis Rush. He's also a big-voiced singer who evokes B.B. King shot through with a deep vein of Gospel.
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and millions of other songs with Rhapsody


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It's all too muchPosted by Jim on Sunday, February 10th, 2008
I wept today. Really really wept. It was the Eighth Continent of trash (twice the size of Texas!), the Haitians eating dirt, the killer whales full of fire retardant, the dust clouds carrying SARS from the African deserts to my back yard, everything…on and on…it's just all too much to fathom, all the pain and suffering people have caused.
I need to take a break and get outside, remind myself that the earth is still here, still beautiful, and worth any amount of work it takes to make any small improvement.


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Bachus Wine Rack by Marcel Wanders
This beautiful matte grey Bachus wine rack is designed by Marcel Wanders (yes, Bachus, not Bacchus). We love its soft, roundy edges and simple peg rack design...
Wanders designed the rack for Slide Design of Italy. We don't really get the bunny in the ad campaign, but we certainly don't object to the cute furball or the minimalist design of the wine rack. Via: Elit Alice.
13 Comments
brought a tear to the eye to see my childhood pet, smoky, in all his fluffy glory...
LOL...that bunny is adorable. I was more focused on him/her than the actual wine rack!
I think the bunny steals the show- I barely looked at the wine rack! Look how soft and fluffy he is...
I agree. Without that adorable bunny these photos would be bo-ring.
this is like car shows where they bring hot women to try to bring attention to the car. except that never works. and now we have a floppy eared goodness staring at us and i have no idea wtf they want to sell.
And apparently grown ups say bunny a lot, too.
Love the wine rack, want that bunny.
Actually, a French Lop.
Sweet, sweet bunny! Give it here for a hug.
The sweet bunny's soulful eyes are meant to distract us from the reality that the wine rack looks like the innards of an iron maiden or maybe a mutant Lego.
There are very few options for modern wine storage, so like the style or not, I am guessing these a welcome addition to the very shallow pool.
Not sure I understand they didn't call it Bacchus, the Greek god of wine and intoxication (well really Dionysus, those god stealing Romans changed is name to Bacchus); makes total sense for a wine rack.
it looks like a big lego, i'd rather have the bunny


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Written by:
I am changing
I am turning to someone
I thought I never knew I would be
Didn't anyone see?
It is hard to smile to myself
It is hard to be that person I once used to be
And Can't you see?
That I was here all along
No more skaters pants
I am now into Jeans
No more baggy shirts
I am now a Punk kid
No more Pop songs
Maybe Not much now
Piano has become my thing
My songs are moody and down
Will I change?
But I am changing at my own will
I don't force
It is just another Natural thing
I am changing
For a better life..


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Credits & Info
- Uploaded
- Apr 29, 2005 | 4:43 PM EDT
- Daily 4th Place April 30, 2005
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Author Comments
Be sure to check out the remake of Barbarian Bob here:
http://www.newgrounds.com /portal/view/492821
Update 1st of May, 2009:
The new and improved Barbarian Bob is here, built from the ground up with new levels, enemy ai, gameplay mechanics, cheats and secret items. The game also supports NG Medals, so have fun earning them all!
Its imperative that you use your shield as much as you can. Or you WILL die.
Rated 5 / 5 stars August 22, 2005
i love this game it is so addictive! i had so much fun playin it!! got to make a 2nd verison!
Rated 4 / 5 stars August 22, 2005
fun action game!
fun action game. though the variety of enemies could be greater and having only 3 lives makes it very hard. it would be much better if say 3 hits took off a life, taking you back to the begining of the level, but once you've then lost all three it would be game over and you'd have to start all over again. though overall you've done an excellent job, these points are just minor details that could in future be improved upon, otherwise, excellent work! keep it up!
Rated 3.5 / 5 stars August 21, 2005
good. . .
The art is good. . .It looked too much like Dan Paladin's style,though. . .so you get an 7.Music - Good,but taken from another game. Interactivity?WAY WAY too slow and frustrating. . .when you die you start back over at the very beginning with 3 lives. . . .and you need ALL those lives. . .Basically,you can get through the ENTIRE game by hitting block,attack,block,attack, then move to the next enemy. . .you need more variety in your enemies or else you can just keep the block,attack,block,attack strategy. . very boring. . and the enemies attack so slow,as well as the player. . . Improve on these. . .good game,though. . .
Rated 3.5 / 5 stars August 21, 2005
simple and nice
I like that it had a simple user interface, like none, =) and it is cute. The graphics are not so intermediate but still no problems..
Rated 3.5 / 5 stars August 20, 2005
ARRGGHHH!!! Frustration!
Very nice. The graphics are nice, although the simple people are a kind of detraction to the backgrounds. I noticed a few glitches in the game, such as invisble cracks in the elevated walkways where you can fall through it and drop back down to the lower level. The game is plenty violent, but it seems pretty difficult. I can imagine many less patient people gnawing on their keyboards after playing this for an hour without getting to the boss.
An expansion of this with a checkpoint feature would probably get a perfect grade. Iron out those glitches and maybe add a continue from second level feature or something. Great job!


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As an alumnus/a of the George Fox MBA program, you have the opportunity to reconnect with your cohort, network with the more than 1,000 fellow graduates, and continue your professional development. This issue of the School of Business eNews features information about each and invites you to:
More detail about each of these topics is below. We welcome your questions and comments!
Amber Russell
New Alumni Benefit - Audit Strategic HR Management Certificate Courses
Completed audit applications should be sent to MBA enrollment counselor Jennifer Macnab at email@example.com.
The MBA Advisory Board is comprised of Jim Cross ('06), Chuck Ferguson, Connie Hanson ('08), Juan Mejia ('06), Therese Monroe ('06), Derek Ridenour ('07), Dan Weldon ('02) and Larry Young.
Spread the Word!
Tell us what you think
George Fox University | 414 N. Meridian Street | Newberg, OR, 97132


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Systemwide News
Staff advisors help give employees a voice
Staff advisors to the regents discuss their experience in bringing the concerns and ideas of staff to UC's senior leadership.
Read about their experience and how you can apply to be the next staff advisor.
Farmers, environment profit from new Cooperative Extension website
CropManage, a new UC Cooperative Extension website for farmers, puts UC Research in the hands of farmers to help them save money and protect the environment.
File taxes, fight cancer
By checking lines 405 and/or 413 on your state income tax forms, you can help fund innovative UC research programs that reach communities throughout California.
Read about how you can help fund UC research.
More Systemwide News
- President Obama presents UC Santa Cruz astronomer with National Medal of Science
- Letter from President Yudof about salary increases
- Innovation center awards 2013 health fellowships
- Tobacco control program saves billions
Read more news at UC Newsroom
People Who Make A Difference
Across UC, staff and faculty make a difference on the job and in their free time. Read about a few of their latest contributions.
The icon of organic chemistry
Charles Perrin is the iconic figurehead of introductory organic chemistry, the primary gatekeeper for students hoping to get into medical school. Now in his 50th year of teaching at UC San Diego, he remains one of the most beloved professors on campus.
Engineering diversity in her field
UC Berkeley mechanical engineering professor Alice Agogino was recently honored for her efforts to significantly increase the number of female, African-American and Hispanic doctorates in her field.
Read about Agoginos long-time mentoring of under-represented minority engineering students.
Do you know someone who is making a difference?
You can nominate a UC staff or faculty member to be featured here. Send their name and a brief description of how they are contributing to UC or their wider community to .
HR Briefs
More HR News
- Take your health assessment and get an award
- Are you ready for retirement? Check your Retirement Readiness score
- UCRP service credit buyback may enable some to retain retiree health eligibility under current rules
You can read more HR news on At Your Service.
Send Your Feedback
What would you like to read about in future editions of Our University? Send your comments and story suggestions to . Our University is produced by UC Communications, External Relations, UC Office of the President.


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German #ELF :) My biases are @imSMl and @henrylau89 :3 My favorite couple is HenMin | I also like SHINee and MBLAQ :)
mion1995.tumblr.com - 180 followers
These categories are free for everyone to enter, simply by tweeting a nomination. Choose one of the Official Categories below or make your own Community Category.
The Shorty Industry Awards recognize the best campaigns and social media leaders of 2013. Entries for the Shorty Industry Awards are now closed. Visit the Shorty Industry Awards Site.
The Shorty Awards honor the best of social media. Millions of people participate in The Shortys to recognize individuals and organizations producing great content on Twitter, Facebook, Tumblr, YouTube, Foursquare and the rest of the social web. The 6th annual ceremony will be held in New York City and livestreamed on the web on April 7, 2014.


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In 2000, the Noble M12 GTO threatened to turn the established supercar market on its head. With its mix of scorching performance, race-bred dynamics and immaculate build quality, the Noble could be bought for a fraction of the cost of most of its rivals, but gave away nothing to them on the road and track. The press raved about it and demand rapidly grew as buyers saw this British-designed car as a credible alternative to cars costing more than twice the price.
There are currently two models in the range: the M12 GTO-3 and the M12 GTO-3R. Both cars use the same engines and underpinnings, but there are significant differences in styling, refinement and transmissions. The M12 GTO-3 is the entry model in the range, with a list price of 47,950. As with the GTO-3R, it has a GRP composite body over a spaceframe chassis offering impressive levels of structural and torsional rigidity. Inside, the cabin is spacious enough to accommodate people over six-foot tall and has excellent ergonomics, adjustable seats and steering column, a fully trimmed safety roll cage and Alcantara trim as standard.
At a list price of 49,950 the M12 GTO-3R is visually identifiable from the GTO-3 by its faired-in twin bi-xenon headlights and Noble-designed ten-spoke alloy wheels. Inside, the 3R has extra noise insulation and full leather trim as standard. But what really sets the 3R apart from the 3, is its all-new Getrag-Ford six-speed gearbox and Quaife Automatic Torque Biasing differential, enhancing its appeal as both a relaxed, high-speed GT and an accomplished track day weapon.
Engine and transmission
On the road, 350lb ft (475Nm) of torque produced between 3500 and 5000rpm makes the car immensely flexible and easy to drive. Even at 3000rpm, the engine is producing 80 per cent of its available torque. There is also very little lag from the twin Garret T25, water-cooled turbochargers, meaning a particularly linear response throughout the rev-range. The turbochargers run a maximum 0.7 bar of boost and are equipped with an air to air intercooler, centrally mounted at the rear of the car.
The all-new Getrag-Ford six-speed manual gearbox, standard on GTO-3R models, has closer intermediate ratios than the GTO-3's five-speed gearbox, but has an even more relaxed top gear than before, running 26.5mph per 1000rpm. This means that at 70mph the engine is turning over at a mere 2650rpm.


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The Minnesota Sports Facilities Authority (MSFA) was established by the legislature in 2012 and charged with the design, construction and operation of the new multi-purpose stadium. The MSFA consists of five members. The new authority is chaired by Michele Kelm-Helgen. The other members are John D. Griffith, Duane Benson, Bill McCarthy and Barbara ButtsWilliams.
Statement from the Minnesota Sports Facilities Authority Regarding the Minneapolis Audubon Society's September 27, 2014 Protest
Vikings Add $49 million to Stadium Budget; SMG is a global leader in facility management
Statement from the Minnesota Sports Facilities Authority Regarding the Audubon Society's Press Release
News Release - August 1, 2014
In May 2012, the Minnesota Legislature and the Minneapolis City Council approved funding for the new $975 million multi-purpose stadium to replace the Metrodome. The new stadium is scheduled to open in time for the 2016 NFL season. Click to view legislation.
email contactMSFA 511 11th Avenue South Suite 401 Minneapolis, Minnesota 55415612.332.0386 TTY: 800.627.3529


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Women upon diets outlay some-more time worrying about what's upon their image than their relationship, says a latest investigate by Atkins.
After contemplating 1,290 women in a U.K., a weight-loss association found 54 percent suspicion about food some-more than sex as well as a entertain felt dieting was some-more critical than their relationship, reports a U.K. Press Association.
Even some-more surprising, a commentary showed women would feel some-more guilty about deviate from their diet devise than intrigue upon their partners.
The investigate additionally suggested which attaining a "beach body" was a series a single proclivity to kickstart a diet, reports Marie Claire. Taunts from others about coming additionally swayed females to watch what they ate.
But what about a conflicting sex? Though group weren't invited to take partial in this survey, an additional investigate out of Ohio State University referred to in Live Science found men suspicion about food as well as nap as most as sex .
"Dieting should never turn an obsession. This is not full of health as it can be opposite productive," Atkins Chief Nutritionist Linda O'Byrne told The Daily Mail. "The final thing anybody wants is for their diet to have any kind of disastrous stroke upon their life."
While it's good to attend to Atkins doesn't hold mania is a approach forward, Blisstree tells women not to attend to "Ms. Atkins Pusher," as well as Jezebel argues a resolution competence be "eliminating a worldwide mania with women's weight. And in which battle, Atkins is upon a wrong side."
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We Are The In Crowd Releases New Song "Rumor Mill"Featured — By HopelessNatalie on July 26, 2011
Hopeless Records is excited to announce that We Are The In Crowd have released the first single off of their upcoming album due out this fall.
The band is gearing up to tour the US and UK with All Time Low starting July 28th!
The song is now available for purchase on iTunes http://itunes.apple.com/us/album/rumor-mill-single/id450643320.
Be sure to keep on the lookout for pre order news!
US TOUR DATES: w/ All Time Low
Jul 28 The National Richmond, VA
Jul 29 Liacouras Center Philadelphia, PA
Jul 30 MAC at Monmouth University West Long Branch, NJ
Jul 31 Bank of America Pavilion Boston, MA
Aug 01 Hampton Beach Casino Ballroom Hampton Beach, NH
Aug 03 The Dome Wallingford, CT
Aug 04 Métropolis Montreal, QC
Aug 05 The Blind Dog Windsor, ON
Aug 06 The London Music Hall London, ON
Aug 07 Elements Kitchener, ON
Aug 10 Burton Cummings Theatre Winnipeg, MB
Aug 11 Louis' Pub Saskatoon, SK
Aug 12 Edmonton Events Centre Edmonton, AB
Aug 13 MacEwan Hall Calgary, AB
Aug 15 Vogue Theatre Vancouver, BC
Aug 16 Knitting Factory Spokane, WA
Aug 17 Knitting Factory Concert House Boise, ID
Aug 19 In the Venue Salt Lake City, UT
Aug 20 Ogden Theatre Denver, CO
Aug 21 Sokol Auditorium Omaha, NE
Aug 22 Val Air Ballroom West Des Moines, IA
Aug 23 Orbit Room Grand Rapids, MI
Aug 25 Egyptian Room Indianapolis, IN
Aug 26 Stage AE Pittsburgh, PA
Aug 27 Rapids Theatre Niagara Falls, NY
UK TOUR DATES: w/All Time Low
Jan 14 Academy Glasgow, UK
Jan 15 Academy Newcastle, UK
Jan 16 53 Degrees Preston, UK
Jan 18 Academy Liverpool, UK
Jan 19 Academy Leeds, UK
Jan 20 Apollo Manchester, UK
Jan 21 Apollo Manchester, UK
Jan 23 Academy Sheffield, UK
Jan 24 Rock City Notthingham, UK
Jan 26 Corn Exchange Cambridge, UK
Jan 28 Academy Birmingham, UK
Jan 29 Great Hall Cardiff, UK
Jan 30 Academy Bristol, UK
Feb 1 Westland Leisure Complex Yeovil, UK
Feb 2 Guildhall South Hampton, UK
Feb 3 Apollo Hammersmith, UK


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Apparently these K-cup brewers are a big deal. The Deal Wizard wouldn't know, since he hates coffee.
For all of you Keurig fans, here's the personal home brewer K45 for a very low $84. We've seen this one at big box stores for $100+.
To get this deal you'll need to use discount code "KCUP30" at checkout.
KTBC FOX 7119 East 10th StreetAustin, TX 78701Phone: (512) 476-7777Fax: (512) 495-7001


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It's for Richard. But I do like Swiss chard and have family in Switzerland : )
Type: Posts; User: Chardful
It's for Richard. But I do like Swiss chard and have family in Switzerland : )
Cool beans I talked to him earlier today. Good to know he's a strait shooter. Looks like I'm gunna just go for it.
Thanks Johnny.
Hey y'all I am on the hunt for a nakiri. I have found one that is could be very exciting it was originally 238.00 and is marked down to 114.00. The maker is ohishi? "Ohishi hammer finished" it is a...
I just thought I'd go with something catchy. Really though epicedge has a 170mm vg10 core 15 fold Damascus hammered for 114.00 down from 230.00 I don't know wether it's a steal or a series defect. I...
Hey simple q what does anyone here know about "ohishi hammer finished"?
Hi everyone