text:
fax: (520) 626-2097.
Liver Biology and Pathobiology---Pathobiology
Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice
Article first published online: 13 AUG 2004
DOI: 10.1002/hep.20302
Copyright © 2004 American Association for the Study of Liver Diseases
Volume 40, Issue 2, pages 386–393, August 2004
Additional Information
How to Cite
McCuskey, R. S., Ito, Y., Robertson, G. R., McCuskey, M. K., Perry, M. and Farrell, G. C. (2004), Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice. Hepatology, 40: 386–393. doi: 10.1002/hep.20302
Publication History
- Issue published online: 13 AUG 2004
- Article first published online: 13 AUG 2004
- Manuscript Accepted: 9 APR 2004
- Manuscript Received: 11 DEC 2003
Funded by
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. Grant Number: RO-1 AA12436
- Australian National Health and Medical Research Council. Grant Number: 153899
- Robert W. Storr Bequest of the University of Sydney Medical Foundation
- Abstract
- Article
- References
- Cited By
In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear whether similar changes occur in other forms of steatohepatitis. We therefore examined whether hepatic microvascular dysfunction occurs in fibrosing steatohepatitis induced by feeding mice a high-fat methionine- and choline-deficient (MCD) diet. Using in vivo microscopic—as well as histological and electron microscopic—methods, together with measurements of alanine aminotransferase (ALT), lipid content, and oxidative stress, hepatic microvascular structure and function were studied in relation to inflammatory and fibrotic changes during evolution of steatohepatitis. At 3 weeks of MCD diet intake, serum ALT was elevated and hepatic steatosis was pronounced. By 5 weeks, necroinflammatory change was noteworthy, and by 8 weeks perisinusoidal fibrosis was established. Compared with mice receiving the high-fat diet supplemented with methionine and choline (controls), levels of hepatic lipid and lipoperoxides were elevated at 3 weeks and beyond. The numbers of perfused sinusoids were significantly reduced at each time point. Enlarged, fat-laden hepatocytes together with perivascular fibrosis narrowed sinusoidal lumens, making vessels tortuous and impairing sinusoidal perfusion. At 3 and 5 weeks, MCD diet caused significant increases in phagocytic activity of macrophages in centrilobular regions. By 8 weeks, macrophage activity was less striking, but the number of leukocytes adherent to the sinusoidal lining had increased 5-fold compared with controls. In conclusion, these results are consistent with a dysfunctional hepatic microvasculature. Thus, microvascular changes may contribute to progressive liver injury in metabolic and toxic forms of steatohepatitis. (HEPATOLOGY 2004;40:386–393.)
Steatohepatitis is a form of liver pathology in which steatosis is accompanied by liver cell injury, predominantly lobular inflammation of mixed cell type, and resultant pericentral and perisinusoidal fibrosis. The archetypical example is alcoholic hepatitis (ASH), but metabolic and toxic etiologies cause steatohepatitis that is histologically remarkably similar. Among the clinical syndromes of steatohepatitis, the most common is that associated with central obesity, insulin resistance, type 2 diabetes, hypertriglyceridemia and other features of the insulin resistance (metabolic) syndrome.1–8 This syndrome, nonalcoholic steatohepatitis (NASH), is the most common liver disorder in the United States, Australia, and most other countries. Histological similarities between NASH and ASH are best explained by the two diseases sharing pathophysiological processes. Understanding such disease mechanisms, and particularly those that result in progressive fibrogenesis and propagation of liver injury, are pivotal to devise treatments that prevent portal hypertension, cirrhosis, and liver failure.
In alcoholic liver disease, accumulation of lipid droplets in the hepatic parenchymal cells causes these cells to enlarge. It has been suggested that this enlargement of parenchymal cells may affect the circulation of blood through the hepatic sinusoids, which in turn may exacerbate hepatic injury by depriving centrilobular regions of oxygen and nutrients. Indeed, this has been reported in genetically obese Zucker rats.9–13 However, several other factors also may contribute to the alteration of blood flow through the hepatic microcirculatory unit in ASH. These include activation of Kupffer cells with release of vasoactive intermediates (endothelins, reactive oxygen species [ROS], nitric oxide, prostanoids) as well as proinflammatory and profibrogenic cytokines, changes to the endothelial cells, activation and contraction of the perisinusoidal stellate cells, and deposition of collagen and other extracellular matrix proteins in the space of Disse.14, 15 The latter change encases the sinusoids with a connective tissue envelope, a process referred to as capillarization. This interferes with the diffusion of oxygen and impairs exchange of nutrients and waste products between hepatocytes and the intravascular compartment.
At present, it is unclear whether any of the above changes occurs in other forms of steatohepatitis, such as NASH. However, in this metabolic type of steatohepatitis, the pattern of hepatic fibrosis resembles ASH, but the inflammatory reaction is generally less exuberant. If microvascular changes do occur in other forms of steatohepatitis, capillarization of the sinusoid and its effects on parenchymal cells could explain why liver failure can eventually ensue, despite apparent resolution of steatosis and hepatitis.
Animal models of human diseases are a useful tool to study pathogenic processes, particularly those that require the intact organ for physiologically meaningful interpretation. There are no entirely satisfactory animal models of steatohepatitis with fibrosis that can be attributed to insulin resistance. However, typical steatohepatitis resulting in perisinusoidal fibrosis, together with at least transient insulin resistance, does occur when rodents are exposed to a high-fat diet and also rendered deficient in hepatic methionine. The latter can be achieved either by deletion of methionine adenosyltransferase type 1A16 or by feeding a diet deficient in both choline and methionine. In the nutritional model, rats or mice develop steatosis with severe oxidative stress and hepatocellular injury during the first 10 days of dietary feeding. This is followed by diffuse and focal lobular inflammation with perisinusoidal and pericentral fibrosis,17–19 thus strikingly resembling the liver pathology of human NASH.
In the present study, we tested the hypothesis that hepatic microvascular dysfunction is a feature of steatohepatitis. To do this, we examined the dynamic and spatial development of microvascular alterations in mice during the evolution of fibrosing steatohepatitis induced by a high-fat, methionine- and choline-deficient (MCD) diet. This was accomplished by examining the livers of anesthetized mice using established in vivo microscopic methods to determine: (1) dimensional changes in hepatic sinusoids, including their functional obliteration; (2) alterations in the patterns and rates of sinusoidal blood flow; (3) leukocyte adherence to the sinusoidal endothelium; and (4) numbers and phagocytic function of Kupffer cells and other hepatic macrophages. The changes were studied first at an early phase (3 weeks), when the predominant pattern of injury is steatosis, then at an intermediate time (5 weeks), when lobular inflammation is fully developed. Finally, we examined livers at 8 weeks of dietary feeding, when steatohepatitis and perisinusoidal fibrosis are fully established. At each of these times, we compared results of microvascular studies with measures of liver injury (serum alanine aminotransferase [ALT]) and pathology, and with biochemical measures of hepatic lipid content and oxidative stress. We also studied the ultrastructural concomitants of microvascular alterations by electron microscopy.
Materials and Methods
All experiments were performed in adherence to the National Institutes of Health guidelines for the use of experimental animals and followed protocols approved by the Animal Care and Ethics Committee of the Western Sydney Area Health Service.
Animals and Experimental Protocols.
Male C57Bl/6 mice initially weighing approximately 25 g were used as experimental animals and fed a 10% lipogenic MCD diet, as reported elsewhere.18, 19 Mice receiving the MCD diet supplemented with DL-methionine (3 g/kg) and choline bitartrate (2 g/kg) served as controls. Both the MCD (ICN 960439) and control (ICN 960441) diet were obtained commercially from ICN (Aurora, OH). The mice were studied 3, 5, and 8 weeks after being placed on the diet, at which times steatosis, necroinflammatory changes, and then fibrosis are evident. There were at least 5 mice in each experimental group.
In Vivo Microscopy.
Hepatic microvascular alterations were examined using established high resolution in vivo microscopic methods under ketamine/xylazine anesthesia (100/10 mg/kg body weight, intraperitoneal), as reported previously.20 Briefly, a compound binocular microscope (Olympus BH-2, Olympus Australia, North Ryde, Victoria, Australia) adapted for in vivo microscopy was equipped to provide either transillumination or epi-illumination as well as video microscopy using a JVC color camera (TK-870E), video monitor (TM-210PS), and S-VHS video recorder (BR-S600E) (JVC-Australia, Kingsgrove, New South Wales, Australia). The liver was exteriorized through a left subcostal incision and positioned over a window of optical-grade mica in a specially designed tray mounted on a microscopic stage. The tray provided for the drainage of irrigating fluids, and the window overlaid a long working distance condenser. The liver was covered by a piece of Saran Wrap (Dow Chemical Co., Midland, MI), which held it in position and limited movement. Homeostasis was insured by a constant suffusion of the organ with Ringer's solution maintained at body temperature. With the ×80 water immersion objective (Leitz, Wetzlar, Germany) employed for these studies, the resolution was 0.3 to 0.5 μm. Microvascular events were observed and recorded for at least 30 seconds for subsequent off-line analysis.
The phagocytic function of hepatic macrophages was assessed by measuring the uptake of fluorescent 1.0 μm latex particles (Fluoresbrite-fluorescent monodispersed polystyrene microspheres; Polysciences, Warrington, PA: excitation 490 nm/emission 530 nm) by individual cells. The latex particles were diluted 1:10 with sterile saline and injected into a mesenteric vein using a 30-gauge lymphangiography needle (Becton Dickinson, Franklin Lakes, NJ). The distribution and relative number of macrophages was measured by counting the number of cells that phagocytosed latex particles in a standardized microscopic field (4,125 μm2) 15 minutes after injection of latex. Phagocytic cells firmly affixed to the sinusoidal wall, including recruited monocytes/macrophages and resident macrophages (Kupffer cells), were considered macrophages. To assess regional distribution, the number of phagocytic macrophages per microscopic field was counted in 10 periportal and 10 centrilobular regions in each animal. The relative adequacy of blood perfusion through the sinusoids was evaluated by counting the number of the sinusoids containing blood flow in the same microscopic fields in which the numbers of phagocytic macrophages were determined. Transmitted brightfield and epi-illuminated fluorescence images were obtained simultaneously to permit imaging of the phagocytosis of the fluorescent latex beads and images of the sinusoidal wall and blood flow at the same time. Because reduced perfusion of individual sinusoids can limit the delivery of the latex particles to phagocytic cells within those vessels, the ratio of macrophages that phagocytosed latex particles to sinusoids containing flow was used as an overall mean index of phagocytic activity of macrophages per microscopic field.
To examine the interaction of leukocytes with the sinusoidal wall, quantification of leukocytes adhering to the endothelial lining of sinusoids was calculated by counting the number of leukocytes per 100-μm length of sinusoid in the same microscopic fields. A leukocyte was defined as adhering to the sinusoidal wall if it remained stationary for at least 30 seconds. The swelling of hepatic sinusoidal endothelial cells (SECs), which is an indication of activation and/or injury, was assessed by counting the numbers of swollen cells whose nuclear regions protruded across one-third or more of the lumen in the same microscopic fields.14, 21–24 The results were averaged and the data were represented as the average numbers of the parameters in each animal.
Following high-resolution in vivo microscopic studies, the hepatic microcirculation was visualized under lower magnification (×10 water immersion objective; Leitz, Wetzlar, Germany) to gain an overview of the hepatic microvasculature. In particular, the overall perfusion was assessed to determine if it was relatively uniform or if it was patchy. The flow and dimensional characteristics in portal and central venules were also evaluated.
Liver samples of the animals studied were collected following euthanasia and fixed in 10% formalin-buffered solution. Paraffin sections were stained with hematoxylin-eosin for histopathological evaluation and Sirius Red for evaluating the presence of connective tissue. The tissue sections were examined and photographed at ×100 to ×400 using a Leica photomicroscope (Leica, Deerfield, IL).
Electron Microscopy.
In at least 3 of the mice from each experimental group, routine methods were used to prepare liver specimens for transmission electron microscopy (TEM).20 Livers were fixed by perfusion of portal veins with 0.1 mol cacodylate buffer to wash out blood, and subsequently, to obtain fixation with 1.5% glutaraldehyde in 0.1 mol cacodylate buffer, pH 7.4. For TEM, small pieces of liver were washed in buffer, postfixed with 1% osmium tetroxide in 0.1 mol cacodylate buffer at 4°C, dehydrated through a graded series of ethanol solutions, briefly rinsed in propylene oxide, and embedded in epoxy resin. Thin sections were cut on a Reichert Ultracut microtome (Leica, Deerfield, IL) and examined and photographed using a Philips CM-12S electron microscope (Philips Electronic Instruments, Mahwah, NJ).
Plasma ALT and Hepatic Content of Total Lipid and Lipoperoxides.
Following in vivo microscopic studies, blood samples were collected from the inferior vena cava and stored at −70°C until required for determination of ALT activity. ALT levels were determined by the Department of Clinical Chemistry, Westmead Hospital, using automated procedures. Samples of liver were stored at −70°C until used for measurement of total lipid content and total lipoperoxides, the latter being a robust marker of oxidative stress. Liver triglycerides were assayed using triglyceride GPO-Trinder reagents (Sigma Diagnostics, St. Louis, MO). Liver lipoperoxides levels were estimated as thiobarbituric reactive substances (TBARS) using 1,1,3,3-tetramethopropane as a standard (Sigma) as previously described.18
Statistical Analysis.
Numerical data are expressed as mean ± SEM. Statistical analyses were performed using ANOVA followed by a Student-Newman-Keuls test for multiple groups. The 95% confidence level (P < .05) was considered significant.
Development of Steatohepatitis and Oxidative Stress in Mice Fed the MCD Diet.
As previously reported, mice fed the MCD diet lost weight compared to those fed the control high-fat diet; however, they otherwise remained active throughout the course of dietary feeding. Liver histology at 3, 5, and 8 weeks confirmed the early and continued presence of steatosis and necroinflammatory changes, while established fibrosis was evident at week 8 (Figs. 1 and 2). At 3 weeks, hepatic parenchymal cells were filled with multivesicular fat, and focal hepatocyte necrosis was seen in the centrilobular region (Figs. 1A and 2A). At 5 weeks, there was a marked increase in unilocular fat droplets, centrilobular necrosis was more conspicuous, and there were occasional fibrotic deposits (Figs. 1B and 2B). By 8 weeks, unilocular fat predominated, and significant centrilobular necrosis was accompanied by infiltration of leukocytes (Figs. 1C and E) and scattered fibrosis (Fig. 2C). ALT levels in MCD-fed mice were significantly increased at all experimental time points compared with controls (Fig. 3A). Total hepatic lipid content increased significantly at 3 weeks and beyond (Fig. 3B). Total lipid peroxides (TBARs; Fig. 3C) were significantly increased at 3 and 5 weeks, and especially at 8 weeks, indicating high levels of oxidative stress.
Changes in Sinusoidal Caliber, Orientation, and Patency.
At all experimental times, in vivo microscopy showed dramatically enlarged lipid-laden hepatocytes compressing and narrowing the lumen of sinusoids, particularly in the centrilobular regions (Figs. 4B and 5A). This gave these vessels a tortuous configuration and appeared to greatly impair sinusoidal perfusion. Flow rates were frequently slow, with cells appearing distinct in contrast to controls, in which flowing cells were blurred. The sluggish sinusoidal perfusion in MCD-fed mice may not be solely attributable to sinusoidal compression because portal and central venules also appeared to be narrowed.
Quantitative assessment of in vivo microscopy revealed that a significant proportion of sinusoids in MCD-fed mouse livers contained no blood flow, a change not seen in livers of animals fed the control diet. Thus, in this dietary steatohepatitis model, numbers of perfused sinusoids were significantly reduced, by 13%, 19%, and 10% at 3, 5, and 8 weeks, respectively (Fig. 5B).
Adherent Leukocytes and Phagocytically Active Hepatic Macrophages.
During the initial 5 weeks, there were no significant differences in the numbers of leukocytes adhering to sinusoids between MCD- and control diet-fed mice. However, at 8 weeks the number of adherent leukocytes in MCD-fed mouse liver was increased 5-fold compared with control liver (Fig. 6A). There was no evidence of swelling of the sinusoidal endothelium during the 8 weeks of MCD (Fig. 6B).
The MCD diet caused 109% and 121% increases in the phagocytic activity of macrophages in centrilobular regions at 3 and 5 weeks, respectively (Figs. 4E and 7). In contrast, dietary feeding reduced this activity in both periportal and centrilobular regions at 8 weeks by 31% and 43%, respectively (Figs. 4F and 7).
Ultrastructural Changes.
Electron microscopy demonstrated loss of fat droplets in stellate cells associated with the appearance of collagen bundles in the perisinusoidal space by 5 weeks of the MCD diet (Fig. 8A); collagen deposition became more prominent after 8 weeks (Fig. 8B). There was the impression that there may be a loss of fenestrae, but this is difficult to quantify and confirmation of this awaits examination by SEM of another series of experimental animals.
The enhanced macrophage activity evident in centrilobular zones by in vivo microscopy was confirmed by TEM at 3 and 5 weeks (Fig. 8C) but was again shown to have diminished by week 8 (Fig. 8D). During these ultrastructural studies of the hepatic architecture, it was also confirmed that hepatic parenchymal cells distended with fat droplets narrowed the sinusoid lumens to make them tortuous (Fig. 8D).
Presence of Microvascular Changes in Dietary Steatohepatitis.
The findings of this study confirm our hypothesis that substantial microvascular changes are present in steatohepatitis caused by factors other than ethanol toxicity. These changes appear to arise initially from the effects of enlarged hepatocytes, swollen with accumulated lipid, compressing sinusoidal lumens, as reported previously in genetically obese Zucker rats.9–13 This, together with collagen deposits in the space of Disse, renders sinusoids tortuous and they become inefficient conduits of blood (or at least of erythrocytes), with resulting impairment of tissue perfusion. That the microvascular changes were secondary to lipid accumulation and oxidative stress in parenchymal cells is suggested by the lack of swollen SECs, which is an early marker of SEC injury14, 22, 23 at any time point (Fig. 6B), and a lack of inflammation, as indicated by leukocyte adhesion to the SEC until significant parenchymal changes already occurred (Fig. 6A).
By in vivo microscopy, the most dramatic change seen was in the number of sinusoids that completely failed to allow passage of erythrocytes. While the in vivo microscopic observations were limited to a sample of the surface of the liver, they are thought to be representative of the entire organ, which is composed of multiple similar functional units (lobules) whose histopathology throughout the liver under these conditions appeared similar. No differences in the responses of the MCD+ or MCD− mice to the anesthetic were seen.
Causes and Consequences of Ineffective Sinusoidal Perfusion.
Dysfunctional (or effectively obliterated) sinusoids were rarely present in control livers but increased significantly from 13% at 3 weeks of dietary feeding to 19% at 5 weeks. Between 5 and 8 weeks, the number of leukocytes adhering to the sinusoidal lining increased substantially, consistent with the appearances on light microscopy of exuberant parenchymal mixed cellular inflammation. Such adherence of leukocytes to endothelial cells is characteristic of an hepatic microvascular inflammatory response.14, 15 In other work, we have shown that hepatic expression of the intercellular adhesion molecules Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule (VCAM) also are increased in MCD diet-induced steatohepatitis.25 We have attributed such changes to up-regulation of nuclear factor κB (NF-κB), in turn activated in the liver by the presence of severe oxidative stress. The demonstration that this secondary inflammatory response is focused, at least partially, on the microvasculature of the liver indicates one possible mechanism whereby metabolic oxidative stress attracts an inflammatory response with the potential to perpetuate liver injury by means of changes in liver perfusion. Although we did not measure oxygen delivery in the present study, others have demonstrated that analogous microvascular changes affect tissue oxygen concentration in the centrilobular region of livers of obese Zucker rats.12
Macrophage Activity in Experimental Steatohepatitis.
Concomitant with the alterations in sinusoidal blood flow observed in the present study, significant increases in phagocytic activity of hepatic macrophages were evident in the centrilobular region at 3 and 5 weeks of the MCD diet. Since these cells in their activated state are known to release ROS and nitroradicals as well as cytokines and vasoactive prostanoids they are also likely to contribute importantly to parenchymal injury, the microvascular inflammatory response, and the activation of adjacent stellate cells with resultant loss of lipid droplets and increased production of collagen. Further studies are clearly indicated to elucidate the extent to which products released by Kupffer cells and SECs could mediate hemodynamic changes in the liver of steatohepatitis, and the present model may be a suitable one in which to conduct such experiments. By 8 weeks, however, phagocytic activity was diminished throughout the lobule. This reduced activity is consistent with the report of diminished Kupffer cell phagocytic activity in the livers of obese Zucker rats.26 Whether this leads to spill-over of gut-derived endotoxin into the systemic circulation and stimulation of increased cytokine production in peripheral tissues, as suggested for the Zucker rat,26 is unknown.
Role of Stellate Cells and Relevance to NASH.
The etiopathogenic factors that perpetuate steatohepatitis in the MCD dietary model seem unlikely to involve insulin resistance because the animals are lean after several weeks of dietary feeding and have low rather than high blood insulin levels27; in this respect, the dietary model differs from NASH. Despite this, the liver pathology is remarkably similar to other "florid" forms of steatohepatitis, such as that found in alcoholic liver disease and in toxin- or drug-induced steatohepatitis or jejuno-ileal bypass steatohepatitis, as well as in cases of class 3 or 4 nonalcoholic fatty liver disease or NASH. It is therefore of interest that by week 8 of the MCD diet, stellate cells adjacent to activated Kupffer cells appeared activated, as indicated by loss of storage (vitamin A) lipid droplets. It was also clear from the associated collagen bundles that, by this time, stellate cells had elaborated and deposited abundant extracellular matrix as part of an ineffective wound healing response. This appeared to continue in the later phase of dietary feeding despite the diminished phagocytic activity of hepatic macrophages by 8 weeks.
Activation of stellate cells also may play a role in modifying hepatic microvascular dynamics because activation increases their contractility and these cells are thought to play a role in the regulation of sinusoidal caliber and blood flow.28–29 It is possible that impairment of blood flow, together with deposition of collagen and other extracellular matrix proteins in the space of Disse, contributes to the continuing liver injury that is a feature of all forms of steatohepatitis. In particular, impaired oxygenation of centrilobular hepatocytes or ROS generated during spontaneous fluctuations in blood flow that cause ischemia followed by reperfusion would explain, in part, the predominant distribution of liver injury and fibrosis in the centrilobular region. It also should be noted that TEM suggested defenestration of the sinusoidal endothelium; this would be consistent with "capillarization" of the sinusoidal wall that is reported to occur during fibrosis and cirrhosis. Confirmation of this loss of fenestrae awaits examination by scanning electron microscopy of another series of experimental animals currently being fed the MCD+ and MCD− diets.
In summary, taken together, liver injury during the development of fibrosing steatohepatitis appears to be associated with, and could result from, a combination of impaired sinusoidal blood flow due to lipid accumulation in parenchymal cells and collagen in the space of Disse narrowing sinusoid lumens. This is exacerbated by leukocytes either mechanically trapped in the narrowed sinusoids or adhering as a result of activation of an hepatic microvascular inflammatory response. The latter involves the activation of Kupffer cells and other hepatic macrophages with the release of proinflammatory cytokines and free radicals that contribute to the inflammatory response, stimulate stellate cells, and exacerbate the oxidative stress (TBARs) in the liver, which progressively increased during the 8-week period of study.
The authors thank Jayshree Seska and Ross Boadle for their technical assistance.
- 1Nonalcoholic fatty liver disease. Gastroenterology 2002; 122: 1649–1657., , .
- 2Etiopathegenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001; 21: 27–41., .
- 3NASH and insulin resitance: insulin hypersecretion and specific association with the insulin resistance syndrome. HEPATOLOGY 2002; 35: 373–379., , , , , , et al.
- 4Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221–1231..
- 5Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severly obese. Gastroenterology 2001; 121: 91–100., , .
- 6NASH: What is it, and why is it important in the Asian-Pacific region? First Okuda Lecture. J Gastroenterol Hepatol 2003; 18: 126–138..
- 7Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50: 1844–1850., , , , , , et al.
- 8Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. HEPATOLOGY 2003; 37: 917–923., , , , , , et al.
- 9
- 10The effect of graded steatosis on flow in the hepatic parenchymal microcirculation. Transplantation 1999; 68: 780–784., , , .
- 11Effect of ischemia-reperfusion injury on the microcirculation of the steatotic liver of the Zucker rat. Transplantation 2001; 72: 1625–1631., , , , .
- 12Increased NAD(P)H fluorescence with decreased blood flow in the steatotic liver of the obese Zucker rat. Microvasc Res 2003; 66: 15–21., , .
- 13Hepatic microcirculatory changes after reperfusion in fatty and normal liver transplantation in the rat. Transplantation 1993; 56: 1076–1082., , , .
- 14Role of endotoxin in the hepatic microvascular inflammmatory response to ethanol. J Gastroenterol Hepatol 1995; 10(Suppl 1): 518–523., , , , , , et al.
- 15Ethanol and the hepatic microcirculation. In: ShermanD, PreedyV, WatsonR, eds. Ethanol and the Liver. London: Harwood, 2002: 191–205..
- 16Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J 2002; 16: 1292–1294., , , , , , et al.
- 17Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. HEPATOLOGY 2003; 38: 123–132., , , , , .
- 18CYP2E1 and CYP4A as microsomal catalyst of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000; 105: 1067–1075., , , , , .
- 19Leptin is essential for the hepatic fibrogenic response to chronic liver injury. JHepatol 2002; 37: 206–213., , , .
- 20Microscopic methods for studying the microvasculature of internal organs. In: BakerCH, NastukWF, eds. Physical Techniques in Biology and Medicine Microvascular Technology. New York: Academic Press, 1986: 247–264..
- 21Morphologic mechanisms for regulating blood flow through hepatic sinusoids. Liver 2000; 20: 3–7..Direct Link:
- 22Responses of the hepatic sinusoid lining and microcirculation to combinations of endotoxin, cytokines and ethanol. In: WisseE, KnookDL, McCuskeyRS, eds. Cells of the Hepatic Sinusoid, 3. Leiden, The Netherlands: Kupffer Cell Foundation, 1991: 1–5..
- 23Kupffer cell activity and hepatic microvascular events after acute ethanol ingesion in mice. HEPATOLOGY 1991; 13: 751–757., , .
- 24Biliary obstruction exacerbates the hepatic microvascular response to endotoxin. Shock 2000; 14: 599–604., , , .
- 25Activation of hepatic NF-kappaB during development of steatoheppatitis in mice [Abstract]. J Gastroenterol Hepatol 2002; 17(Suppl): A154., , , .
- 26Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci U S A 1997; 94: 2557–2562., , , , .
- 27The methionine-choline deficient (MCD) diet model of NASH is associated with hypoglycemia and diminished serum insulin levels [Abstract]. HEPATOLOGY 2002; 36: 402A., .
- 28Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat. HEPATOLOGY 1995: 1565–1576., , , , , , et al.
- 29Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994; 266(Part 1): G624–G632., , .


text:
Posters is excessively majestic and makes a right wall decoration, this dimension isand the price is $0.00. If you're trying to explore top recommendedPosters with cheap price, this product is the nice deals for you.
We work withPosters dealers who have a popular reputation. This unit is supreme, the finishing of the poster isn't the best, for for the cost, it is glaring. It is majestic enough to frame, quality print and looks just like the original featured in this product. We have all the latest fun and electric this one related to entertainment!Posters is extremely low-priced and arrived soon in intense packaging that protected the product very well. The item is a supreme size -and it looks imposing on the wall and in a frame. The unit is a aggregate sized poster, printed on cool paper, with sunny color and glittering finish. The one is immoderately huge, the valuable sizefor the affordable price that it is.Posters colors are heart-stirring, and the details are colorful.

subset: commoncrawl


text:
By Sport
- Selected:
- All Sports
- Selected:
By Section
By Columnist
By Insider
By Player
By Team
- Selected:
Oakland Raiders
- All Teams
- Selected:
154 results for "a s trade"
Where will Rex Ryan coach next?Tom Carpenter
The New York Jets made a huge trade this week, acquiring a legitimate game-changing playmaker in WR Percy Harvin. Unfortunately, it's likely too little too late, as they sit at 1-6 after losing on Thursday night. Not only is the trade likely too late...Blog | October 19, 2014
Fantasy Football - Pick up Austin Seferian-Jenkins right nowMike Clay
Need an edge in your Week 5 fantasy football matchup? Mike Clay of Pro Football Focus has you covered with 32 start/sit, pickup and trade tips, covering each NFL team.Story | Conversation | September 30, 2014
Check the tape: What's Durant's best fit?Todd Archer
IRVING, Texas - Listening to some tape from the Dallas Cowboys' minicamp offers some perspective on the team's move to trade for linebacker Rolando McClain. After one minicamp practice, I asked linebackers coach Matt Eberflus if the starting middl...Blog | July 03, 2014
Rolando McClain dealt to Dallas Cowboys by Baltimore Ravens, will...
The Dallas Cowboys completed a trade with the Baltimore Ravens on Tuesday to acquire linebacker Rolando McClain, who will come out of retirement, a league source told ESPN NFL Insider Adam Schefter.Story | Conversation | July 01, 2014
Our mock draft, final versionRich Cimini
Our third and final crack at the first round. To keep things orderly, I didn't include trades: 1. Houston Texans : Jadeveon Clowney, DE, South Carolina -- Still think there's a decent chance the Texans trade down and pick a quarterback. 2. St. ...Blog | May 08, 2014
Exploring possible trade partnersBill Williamson
Earlier Tuesday, we looked at why a trade with Baltimore to move up to No. 17 in the first round of next week's draft would make sense to the San Francisco 49ers. Truly, any team is a potential trade partner when the clock starts and the board sta...Blog | April 30, 2014
Pryor garners Raiders 3rd seventh-rounderPaul Gutierrez
The Oakland Raiders' trade of quarterback Terrelle Pryor on Monday to the Seattle Seahawks for the Super Bowl champions' seventh-round draft pick garnered the Raiders a total of seven selections in May's NFL draft. It also gave Oakland three seven...Blog | April 22, 2014
Changing draft dynamics around the Rams?Nick Wagoner
EARTH CITY, Mo. -- It's widely assumed the St. Louis Rams would like to trade down from their No. 2 overall pick in the 2014 NFL draft. Whether that is the right move is debatable, but much of that discussion will hinge directly on what type of offer...Blog | March 21, 2014
How will Schaub affect OAK QB plans?Tom Carpenter
As ESPN NFL Insider Adam Schefter reported Friday morning, the Oakland Raiders will trade a late-round pick in this year's draft to acquire veteran quarterback Matt Schaub. What does this move mean for the rest of the Raiders QB corps? That's up for ...Blog | March 21, 2014
2014 NFL Free Agency - Examining the best team fits for Chris Joh...Matt Williamson
With running back Chris Johnson almost certainly headed to free agency, Matt Williamson identifies five teams that should target him.Story | Conversation | March 10, 2014
Trade suitors for Texans' No. 1 pickNic Reiner
Houston Texans owner Bob McNair is open to trading the No. 1 pick in this year's NFL draft. Which teams might be willing to trade all the way up? It's probably smartest to begin with those teams who need a quarterback. Louisville QB Teddy Bridgewa...Blog | January 04, 2014
Fantasy Football - Which defenses to start players against in the...KC Joyner
KC Joyner identifies specific defensive units against which fantasy football owners should start their players, including the Miami Dolphins' run defense and the Detroit Lions' pass defense.Story | Conversation | November 26, 2013
What to make of Trent Richardson trade, Robert Griffin III value,...Christopher Harris
Christopher Harris reviews some top issues for Week 3, including Trent Richardson's value in Indy and whether Robert Griffin III will turn things around.Story | Conversation | September 20, 2013
Bill Barnwell on NFL bets made for the 2013 seasonBill Barnwell
Let's kick off the NFL season with a trip to Las Vegas to put our money where our mouth is.Story | Conversation | September 06, 2013
Did Bengals get value from Palmer picks?Jamison Hensley
There's no question that the Cincinnati Bengals were the big winners in the Carson Palmer trade with the Oakland Raiders. The Bengals received first- and second-round selections for Palmer, who lasted two seasons and won a total of eight games. Bu...Blog | May 02, 2013
Thoughts on Raiders, Chargers draft tradesBill Williamson
ESPN's Mel Kiper Jr. explains that both the Oakland Raiders and the San Diego Chargers face dilemmas in the first round. Kiper wonders whether the two rivals could work together on a trade involving the No. 3 and No. 11 picks. Such a trade could ...Blog | April 19, 2013


text:
Choose your preferred language. We speak English and 41 other languages.
Most often used by people in the United States
All languages
FREE cancellation on most rooms!
Instant confirmation when you reserve
|Stirling Court Hotel University Of Stirling Campus, Stirling
Score from 683 reviews: Very goodLocated on the University of Stirling campus and set in 300 acres of beautiful parkland, Stirling Court Hotel is just 10 minutes' drive from Stirling city centre.
Latest booking: 4 hours agoThere is 1 person looking at this hotel.
"Clean hotel, helpful staff, perfect location for university business."
$79 Average price per night
|Terraces Hotel 4 Melville Terrace, Stirling
Score from 209 reviews: GoodTerraces Hotel has a central yet peaceful setting with private parking, ideal for Stirling town centre and Braveheart country. There is free Wi-Fi access in rooms and public areas.
Latest booking: 7 hours ago
"This hotel is well situated in the city. The personnel is very friendly. The meals are good and inexpensive."
$79 Average price per night
|Holiday Inn Express Stirling Springkerse Business Park, Stirling
Score from 366 reviews: Very goodWith modern and comfortable accommodations, the 3-star Holiday Inn Express Hotel presents itself as an ideal base from which to explore the attractions of Stirling and central Scotland.
Latest booking: 4 hours ago
"Located in an industrial park and probably marketed towards business travellers. Good restaurant next door, ample parking, excellent WIFI. Good breakfast and attentive staff"
$67 Average price per night
We've negotiated with thousands of hotels to get the very best deals. We call them Secret Deals and they only last for a limited time.
You can get these deals for free by subscribing to our newsletters. You can even choose your favorite destinations to receive personalized deals.
Get started now by entering your email address. We'll instantly send you a link to our Deal Finder!
Don't worry – your email address is safe with us. We'll never share your private information and you can unsubscribe at any time.


text:
Alira Astro similar galleries
Marvelous teen Sarah Sinn
04:53, 1738, 2 years
Hawt teen Sarah Sinn
Hannah Lawley showing off tits
16, 1492, 4 years
Come in to see hot Hannah showing off her perky tits in here.
Mackenzie Star in hardcore..
15, 2452, 4 years
Mackenzie Star in deep and hardcore fucking
What's Prom Without the porno..
08:00, 817, 23 days
What's Prom Without the porno Featuring giant knocker Chantelle Skye
Horny chick in spermfalls
15, 3302, 5 years
Amazing chick enjoying sucking cocks with sperm falls
Shy Secretary
14, 1764, 2 years
Live hot nude hardcore sex.Hardcore totally spies porno.
Leah Moore hot MILF double..
02:00, 3307, 5 years
Sexy blonde MILF Leah Moore takes 2 dicks
Hot blond babe enjoys the..
02:00, 4355, 3 years
Gonzo dirt and pleasure cocktail the horny bitches share in this xxx tube..
Free blowjobs and hardcore sex..
02:18, 2401, 2 years
Hardcore monster cock blowjobs.
Vigorous doll Devon Alexis Is..
08:00, 711, 1 month
Vigorous doll Devon Alexis Is the wife inside Need
Diane Diamonds
03:00, 5564, 2 years
Diane Diamonds
Free stories of married women..
05:17, 2919, 3 years
Girls getting paid to fuck.
- Girl in blowjob action 16 pictures
- Blonds lined up to get a Toy in their apertures, one by one! Streaming 02:01
- Taylor Hillton fucks with fuck machine 15 pictures
- Blonde Executive MILF Is A Private Cutie 16 pictures
- Sexy blonde Jana Jordan 17 pictures
- Jock sucking professIonals work on cock to get asses sex creamed Streaming 02:00
- Huge rack babes hardcore 21 pictures
- Silvia Saint getting her fuck Streaming 02:00
- Anka Romensky - Summer Desire Streaming 06:12
- Sexy teacher Lara reading naked 16 pictures
- Vanessa Gold 1 video, 9 pictures
- To smoke a dick is a tasty thing for a porn whore 8 pictures
- Mariah Milano exposing her tits Streaming 03:59, 23 pictures
- Naughty cougar Joey Lynn 15 pictures
- Bigtitted blonde bombshell, Sophia Rossi, presents off her generous curves showing off all over A Aziani motorcycle in her tank top and shorts. Even better is when she has it all off! 15 pictures
- Babe playing with her foot 16 pictures
- Hot and sexy doll fucks her horny boyfriend hardcore 14 pictures
- Tommi Rose acquire her cookie lick and dildo fuck hard Streaming 04:57
- Foot fetish with lesbians Renee Larue and Daisy Chain Streaming 02:06
- Becca Bratt Streaming 03:01
- Awesome lust Drew Butterfly swallows cum Streaming 02:00
- "Tender flesh and fresh looking gal is wide open to new ideas." 16 pictures
- Cute young slut Tight Kacey shares her pussy Streaming 02:00
- Fatty Brianna Falcone in hard fucking 16 pictures
- Justin Long fucks Tianna Love 16 pictures
- Sexy lesbian babes in wild pussy and ass licking Streaming 05:00
- Pictures of teacher woman fuck by her student 15 pictures
- Lovely teenie Heather Zatch deepthroated Streaming 03:25
- T.J. Hart banged by Joe Blow 15 pictures
- Big boobs babe Tanya James in hardcore fucking 15 pictures


text:
Gulf | Qatar
Qatar pledges $500m in aid to Darfur: minister
Britain on Sunday pledged at least $16.5 million annually for the next three years
Doha: Qatar pledged $500 million (Dh1.8 billion)in aid to rebuild Sudan's war-ravaged western region of Darfur, the official QNA news agency on Monday quoted a minister as saying.
"Qatar has pledged an amount of $500 million as grants and contributions for rebuilding Darfur," said the gas-rich emirate's minister of state for cabinet affairs, Ahmad bin Abdullah Al Mahmoud.
In February 2010, Qatar had promised to establish a bank with a capital of one billion dollars to develop Darfur.
Britain on Sunday pledged at least $16.5 million for Darfur annually over the next three years to help communities to grow food and to boost skills for employment.
The latest announcement came as delegates met in Doha for a second day for a conference aimed at endorsing a strategy to rebuild Darfur, where a decade-long conflict shocked the world with atrocities against civilians.
The conference, which drew condemnation from rebel groups still fighting the regime, was agreed under a July 2011 peace deal which Khartoum signed in the Qatari capital with an alliance of rebel splinter groups.
It seeks support for the six-year, $7.2-billion strategy to move Darfur away from food handouts and other emergency aid, and lay the foundation for lasting development through improved infrastructure.
The meeting comes 10 years after rebels rose up in the western Sudanese region to seek an end to what they said was the domination of power and wealth among the country's Arab elites.
In response, government-backed Arab Janjaweed militia committed atrocities against civilians, prompting an arrest warrant for President Omar Al Bashir over alleged war crimes, crimes against humanity and genocide.
While the worst of the violence has long passed, rebel-government clashes continue along with inter-Arab battles, kidnappings, carjackings and other crimes.
Some 1.4 million people have been displaced by the Darfur conflict.
More from Qatar
Verdict next month for US couple in Qatar
GCC foreign ministers to meet in Doha: Report
Safety to be focus of new health conference
Bush painting hits record at Doha auction
More from Gulf
News Editor's choice
Footballer dies after celebrating goal
Twenty-three-year-old footballer's untimely death a "big shock" to teammates
Al Wasl Road traffic to be diverted soon
Work on four-lane flyover next to Safa Park begins after diversions are complete
UAE trial of 15 accused of terror
Prosecutor demands harsh punishment for ddefendants on trial for creating terrorist group
Housewife accused of assaulting maid
Female employer allegedly attacked her maid in Ajman over lost car key


text:
Popular now on WCYB.com
States with strongest, weakest gun laws
POSTED: 11:29 AM Jan 14 2013 UPDATED: 12:24 PM Apr 01 2014
Text Size:
Georgia Gov. Nathan Deal signed into law Wednesday new gun legislation that allows licensed owners to carry firearms into more public places than at any time in the past century, including government buildings, bars, and a wide variety of public places. Take a look at which states have the strictest and weakest gun laws.
Around The Watercooler
- Chili's cook fired over shirtless kitchen pics
- Man brings hatchet to school; 'seemed like a good idea'
- Teen arrested after giving waitress tip covered in feces
- Mom accused of giving baby to heroin user
- Tropical spider burrows into Aussie man's stomach
- Stinking mess: Truck carrying portable toilets crashes
- U.S. tourist gets trapped in London bookstore
- Woman buys year's supply of pumpkin spice lattes
- Haunted house worker gets a little too creepy


text:
News » Up To £20m » Merton renews highways deal » published 18/07/2012
Merton renews highways deal
Merton Council has reappointed FM Conway to look after its highways services for another five years.
The new contract starts on 1 September 2012 and will run until 2017, with an option for a two-year extension.
Under the terms of the contract, FM Conway will continue to provide the council with a range of services including highway maintenance, carriageway surfacing, lining, civil engineering, traffic management and drainage works.
FM Conway and Merton Council have worked in partnership for more than 30 years.
FM Conway contracts manager Gus Smith said: "Merton means everything to FM Conway. It's our flagship borough. At any one time, we have 60 people working in the borough. We've grown up together and developed together, and look forward to a successful future where we can explore exciting innovations together."
Download our free construction news iPhone / iPad app. Sign up to our FREE email newsletters or subscribe to our RSS feed for regular updates on the latest Construction News, Plant News, Contract News & Supplier News. The Construction Index also provides the latest Construction Tenders, Construction Market Data & Construction Law Commentary all FREE.
This article was published on 18/07/2012 (last updated on 18/07/2012).
More News Channels
- CPA revises growth forecasts upwards
- Crossrail TBM Ellie breaks through in Docklands (with video)
- Banner provides springboard for Cala growth
- Prefab solution for Scottish social housing
- Plumbers and plasterers join brickies and chippies on construction's most wanted list
- Click here to browse all articles
- Scottish government wins winter maintenance action
- Fifteen months in jail for breaching height safety regs
- Florrie's law caps building repair bills for council housing tenants
- Status of electronic documents explained
- Holiday pay ruling could be death knell, warns civils contractor
- Click here to browse all articles


text:
Freelance Model
Liquidation Channel is looking for amazing talent, Freelance Model's, to showcase our products and assist in promoting, advertising, and driving demand for Liquidation Channel's jewelry, fashion accessories, home and lifestyle products.
Oct 21 -
Event Communications Assistant-Entry Level
Event Communications Assistant-Entry Level
Paid Training-Travel Opportunities-Entry Level Management Opportunities
-Implementation of marketing plans, including product positioning, campaign strategies, and market strategy insights.
Oct 20 -
Marketing Communications Assistant
Marketing Communications Assistant
PURPOSE: Marketing and communication for company-Paid Training-Travel Opportunities-Management
-Implementation of marketing plans, including product positioning, campaign strategies, and market strategy ...
Marketing Communications Intern
Marketing and Communications Intern
Job Summary:
Under general supervision and according to the established policies and procedures, the Marketing and Communications Intern is responsible for assisting the communications department with a variety of internal and external ...
Oct 7 -
Online Marketing Specialist
Job Description
CompAndSave.com is opening a new office in Downtown Austin after Bay Area, CA. We are looking for talented online marketing professionals to join CompAndSave.com's fast growing online marketing team. As our online marketing specialist, you will work on day ...
Oct 4 -
Social Media & Marketing Manager
XTech is currently looking for Social Media and Marketing Manager for our South Austin, TX office.
Responsibilities Include:
A self-starter attitude. An ability to stay on task and work with minimal direction
Managing media content marketing, blogging, and social media ...
Oct 2 -
SEO Specialist
SaleAMP is currently looking for a highly motivated SEO Specialist with a proven history in the digital marketing space. The ideal candidate is exceptionally organized and deadline driven with the strategic, analytical, and technical capability to collaborate with internal ...
Sep 29 -
Online Marketing Associate
Job Description
CompAndSave.com is opening a new office in Downtown Austin after Bay Area, CA. We are looking for talented internet marketing professionals to join CompAndSave.com's new and fast growing marketing team. As our online marketing associate, you will work on day ...
Digital Public Relations Specialist
SaleAMP Austin is currently looking for a highly motivated Digital Public Relations Specialist with a proven history in the digital marketing space. The ideal candidate is exceptionally organized and deadline driven with the strategic, analytical, and creative capability to ...
Sep 23 -
Digital Advertising Campaign Manager
Software Advice is looking for an online advertising rising star looking to evolve their skill set to take on new challenges across paid search (PPC), retargeting, display, content syndication, and partnerships. If you have one to three years of experience in all of these ...
Sep 5 -
Director of Marketing – Great Opportunity – Los Angeles, CA (9257)
Leading independent producer and distributor of programming in the worldwide television marketplace is seeking an experienced Director of Marketing who excels in a fast-paced and dynamic environment.
• Bachelor's degree in Marketing
• At least 5 years of ...
Sep 4 -
Marketing Manager
Marketing Manager
A fantastic opportunity has arisen to join a global, market leading Technology Company with offices in Austin, Texas. LearnPad Inc. develops award-winning classroom tablet solutions for the K12 education market. We are seeking a talented Marketing ...
Sep 2 -
Fun Health and Beauty In Store Demo
We are looking for one outgoing, friendly female to work an in-store demonstration for a popular line of health and beauty products. You will be educating customers about the brand and taking photos of woman at the event and encouraging them to post to their social media ...
Aug 29 -
Fun In Store Health and Beauty Event
Aug 29 -
Round Rock
In Store Health and Beauty Demo
Aug 29 -
College Station
Are you a social organizer at school? Be a Spangle Campus Ambassador!
We're looking for an exclusive group of college students to step into the social media spotlight on their campus and become Spangle Campus Ambassadors. Will you represent Spangle on your Campus?
Are you passionate about throwing events? Do you enjoy getting people together ...
Aug 27 -
We'll be sending text message alerts for your subscription to


text:
"Look What I got !!!"
Description from Mary S - Sweet Chick: Here's a few of the beads I just got (plus a few I'd like to have).
The Silver Creek jasper pendant I recieved has a greenish/pink tone to it and was thinking of mixing in the pistachio and angel skin pearls to accent it. The antique soocho jade looks good next to it too. Now I need a design. Any suggestions Chickies? What else could I add?
- "Ocean Tribe": on
"Thank you But shouldn't another pick be on sale today? Lima team where are…" read »
- "Thunderstorm": on
"Don't like thunder but like this …" read »
- "Peaceful Forest": on
"Ditto to above!!…" read »
- "You have my heart": on
"Pretty …" read »
- "Aggie Says Hi!": on
"Hi Aggie, you funny lady, yes you too, Becky! Great pick …" read »
- "Already Looking for Spring?": on
"Me tooo, me too is looking for the spring. Don't want winter... Awesome pick, love it…" read »
- "Twilight in the Tweetops": on
"Fabulous and great title Seems like the rust just rained of you …" read »
- "Things Lost": on
"Some goodies here!!…" read »
- "Things Found": on
"Hope some of these beads finds its way home to you too …" read »
- "Bridal Veil": on
"Pretty bridal pick …" read »
- "Liz's Eyes": on
"Very chic-could make a very dramatic necklace!…" read »
- "Already Looking for Spring?": on
"Added to my favs!…" read »
- "Peaceful Forest": on
"I like the metal colors with the green. Pretty!…" read »
- "Eye candy": on
"Thanks everyone! I'm new to this site, and so glad to find a new "toy"...I'm enjoying…" read »
- "Thunderstorm": on
"This is so vibrant! Love it!…" read »
- "Peaceful Forest": on
"Fab components for your theme!…" read »
- "You have my heart": on
"Very pretty!…" read »
- "Aggie Says Hi!": on
"Missed you Aggie! Glad to have you back in this stunning pick!…" read »
- "Already Looking for Spring?": on
"Gorgeous,Becky! Gotta get through fall and winter, but this keeps me hopeful!!…" read »
- "Twilight in the Tweetops": on
"Fab pick, Becky! Fun title! Nary a rusty spot...…" read »
- "Olivine in the pinks": on
"Thanks ya'll.…" read »
- "Ocean Tribe": on
"Cool pick Frida! Congrats on POD!…" read »
- "Peaceful Forest": on
"Your pick evokes exactly what is intended. Lovely, peaceful. The owl is adorable, never saw that…" read »
- "Thunderstorm": on
"Your title is perfect for all the interesting elements in this creative pick ... I can…" read »
- "Ocean Tribe": on
"Gorgeous pick! So many ideas here. Congrats!…" read »
- "You have my heart": on
"Fabulous pick!…" read »
- "Aggie Says Hi!": on
"Very cute pick, would love to see a finished piece!…" read »
- "Already Looking for Spring?": on
"Another stunning pick, love it!!!…" read »
- "You have my heart": on
"I think you really nailed this design! The colors, textures, and composition are perfect.…" read »
- "Already Looking for Spring?": on
"I love Fall. I just wish it would last longer but you know I can't go…" read »
- "Aggie Says Hi!": on
"I've been way too busy and so has Aggie. I hope life slows down…" read »
- "Already Looking for Spring?": on
"I'm still looking for Fall here in Florida, but I love this pick, Becky! The colors…" read »
- "Aggie Says Hi!": on
"Hi Aggie! Wonder what adventures you've been on...You too, Becky!…" read »
- "Twilight in the Tweetops": on
"Thanks, Ladies! It was fun to put together but I am so rusty it took…" read »
- "Twilight in the Tweetops": on
"I love this!…" read »
- "Twilight in the Tweetops": on
"Stunning, straight into faves!!! The composition, colors, and title are all awesome. I hope this is…" read »
- "The Raven": on
"Wow! I missed this and the POD. Hubby says "Good thing, too!" !…" read »
- "Earthy Ocean": on
"W.O.W. !!!!…" read »
- "Olive all these great combos": on
"Very lovely Fall colors, Nancy! …" read »
- "Chocolate Love Affair": on
"It's great to see you back again and with such a DELICIOUS pick! …" read »
|16" strand
|½ strand (loose)
16" strand
Was $6.70 — You save 25%
½ strand (loose)
Was $3.70 — You save 25%
Last Chance—All sales final.
|16" strand
|½ strand (loose)
Read the comments (or add your own)
sweet chick,
what a fun question, glad to hear you got some silver creek jasper, that's one I've had my eyes on, havent seen this stone at other companies' sites. very fascinating to hear it has greenish and pinkish overtones… the silver moonstone looks like it would go well, plus the antique soochow jade and the pearls you have, will be fun to hear what everyone else suggests!
Just so you know Joyce, they don't all have that green/pink color to them. I have some of the other size beads and the colors vary from shades of grey with a bit of burgandy and some have more of a neutral soft brownish tone to them.
Thanks for the comments!
wow, fascinating to hear about the variances in this stone, gray with a bit of burgundy, or soft browns w/ the greens eh? the golden wooden jasper, copper and silver green pearls, plus vintaj brass look like they also combine well with the silver creek jasper!!! hope you'll make something with that new pendant and post some pics okay???
I'm thinking the silver green pearls, soocho jade and the jasper pendant with brass or copper.
Beautiful pick! don't you just love it when that box comes in the mail!
I agree with Gem, you have to use a different metal, like brass- to tone the colors down, or, copper to blend the colors!!! love these colors!!!
Thanks Chickies! Keep the comments coming.
I love it when someone else can make some decisions for me. I am such a procrastinator when it comes to making decisions.
It helps to have creative input from others who share your passion for beading. This is the only place I can get that input. No one else in this small town beads(that I know of).
Beautiful pick! Great bead choices!
Hi Sweet Chick! I know what you mean, I tend to procrastinate a lot too, especially when it comes to making creative decisions. But when you step away from your design for a while and then come back to it later, sometimes the perfect design just pops out at you. Of the stones you have in this pick I actually like the copper pearls with the jasper pendant. And I would use brass spacers/beads to keep some of that brown from the pendant. Good luck designing and I hope you'll post a pic of what you came up with!
If I ever learn how to post pics I certainly will. (Part of my procrastination AND lack of Techno geek genes).
Comments are closed for this Fresh Pick.
Design Your Own!
The Fresh Pick on this page was designed by a customer. You can design your own Fresh Picks, too!


text:
UAE | Health
Disease Prevention and Screening Centre opens in Ghayathi
Disease Prevention and Screening Centre opens in Ghayathi
Abu Dhabi: A new Disease Prevention and Screening Centre opened on Monday in the Ghayathi area in the Western Region, the Ambulatory Healthcare Services announced in a statement.
The centre was moved from its former location in Ghayathi Hospital to a new dedicated facility located in the Al Dhafra Club in Ghayathi.
According to AHS officials, the new location offers improved facilities to patients, including a dedicated waiting area for women.
At present, 150 residents on average make use of the Ghayathi DPSC services every day. The number of people seeking visa screening services at the DPSC in Ghayathi also increased by about 4,000 residents from 2010 to 2011.
More from UAE Health
Muslim physicians urged to fight to polio
Sixth UAE Cancer Congress inaugurated
First aid initiative discussed at meeting
Brit chef's pink drive draws peers' support
More from UAE
Latest news
- Muslim physicians urged to fight to polio
- Man jailed for using forged report to use drug
- Twin brothers jailed 6 months over drug abuse
- Duo jailed for organising gambling game
- Sixth UAE Cancer Congress inaugurated
- Hospitality championship gets cooking in Dubai
- Two jailed for trying to steal Dh250,000
- Child falls to death, parents charged
- UAE praises Morocco's efforts to fight terrorism
- Dubai Government departments to mark Flag Day
- 'Piracy fight needs jobs for youth'
- Police uncover attempt to smuggle 4.5m pills
- Man denies abusing mentally-challenged mother
- Poll panel discusses FNC voting process
- Chicken nuggets are safe: officials
Community Reports
No landscaping in Al Nahda area
Gulf News reader says the authorities haven't worked on beautifying the area.
Pedestrian bridge is need of the hour
Reader requests the authorities to construct a pedestrian bridge in the Ras Al Khor area, in Dubai.
Activism of any form is important
Ppeople need to be more responsible about the activism they participate in, says expert.
Participation in online campaigns supported
Online campaigns allow people to express their support for a cause.


text:
A group of international non-governmental organizations released a joint statement Friday urging world leaders to establish a global development framework that prioritizes human rights and normative justice over aid-based models after the expiration of the UN's eight Millennium Development Goals ( ...[read more]
UN Secretary-General Ban Ki Moon said in a statement delivered Sunday to the African Union summit that the leaders in Africa must increase efforts to lower poverty levels, end cycles of violence and accelerate development. Ban noted that while many countries have made strides to achieve the UN's ...[read more]
Amnesty International (AI) urged world leaders to strengthen the Millennium Development Goals (MDGs) to meet international human rights standards in a report released Wednesday. The report, From Promises to Delivery, focuses on three main areas where governments can improve the MDGs during the ...[read more]
The rule of law is a necessary prerequisite to achieving all eight of the UN's anti-poverty Millennium Development Goals (MDGs), UN Office on Drugs and Crime Executive Director Antonio Maria Costa said in an address Monday at the opening of the 17th session of the UN Commission on Crime Prevent... ...[read more]
Loyola Law School
St. John's University School of Law
South Texas College of Law
George Mason University School of Law
National LGBT Bar Association
New York University School of Law Public Interest Law Center
JURIST is a 501(c)(3) non-profit organization dedicated to bringing objective legal news and reasoned expert analysis to the public.
E-mail inquiries, changes, news tips, URLs, corrections, etc. to email@example.com.
JURIST cannot and does not provide legal advice. As such, nothing on this site is intended as legal advice. If you have a legal problem, please consult an attorney.
We wish you the best of luck with your case, but we can't help.
© Copyright JURIST Legal News and Research Services, Inc., 2013.
Please note that JURIST cannot and does not provide legal advice.
As such, nothing on this site is intended as legal advice. If you have a legal problem, please consult an attorney.
We wish you the best of luck with your case, but we can't help.


text:
User talk:SaltedCracker
January 2009[edit]
Killed the note.sinneed (talk) 07:08, 3 January 2009 (UTC)
- Possibly an error. I will look at it immediately.sinneed (talk) 07:02, 3 January 2009 (UTC)
- OK, 1st, if you make a *HUGE* edit like that, an edit summary will help, a lot.
2nd, if you insert an image named "Replace this image male.svg", it looks very broken. I waffled on it. I waffled on the warning. Sorry. Shall I roll back to the edit I reverted so you can fix it, or do you want to move forward from here?sinneed (talk) 07:07, 3 January 2009 (UTC)
- OK, I saw NO edit summary... but there they are. I am going to reboot. I have seen this once before. My profound appologies. I reverted my edit. You should be good to go. :,( sinneed (talk) 07:11, 3 January 2009 (UTC)
- Cool, no problem. In case you were wondering, the reason I put that image there was simply that that was what was there previously. I merely copied the code from before Rockyobody removed Thomas Knapp, since he gave no reason for removing a confirmed, sourced candidate.SaltedCracker (talk) 07:17, 3 January 2009 (UTC)
- OK, I saw NO edit summary... but there they are. I am going to reboot. I have seen this once before. My profound appologies. I reverted my edit. You should be good to go. :,( sinneed (talk) 07:11, 3 January 2009 (UTC)
- OK, 1st, if you make a *HUGE* edit like that, an edit summary will help, a lot.
Orphaned non-free image File:FirstOperationalDragon.jpg[edit]
Thanks for uploading File:FirstOperationalDragon.jpg. The image description page currently specifies that the image is non-free and may only be used on Wikipedia under a claim of fair use. However, the image is currently orphaned, meaning that it is not used in any articles on Wikipedia. If the image was previously in an article, please go to the article and see why it was removed. You may add it back if you think that that will be useful. However, please note that images for which a replacement could be created are not acceptable for use on Wikipedia (see our policy for non-free media).
- I am a bot, and will therefore not be able to answer your questions. If you have a question, place a {{helpme}} template, along with your question, beneath this message.
- I will remove the request for deletion if the file is used in an article once again.
- If you receive this notice after the image is deleted, and you want to restore the image, click here to file an un-delete request.
- To opt out of these bot messages, add
{{bots|deny=DASHBot}}to your talk page.
- If you believe the bot has made an error, please turn it off here and leave a message on my owner's talk page.
Thank you. DASHBot (talk) 05:44, 21 November 2011 (UTC)
Request for comment[edit]
Hello SaltedCracker, I'm here onbehalf of WP:ORPHAN in which you are also a participant. So, we want your opinion to a WP:ORPHAN related matter. It is a proposal by Technical 13. Please have a look here. Your opinion (i.e support, oppose etc) are very much appreciated there. Thank you. By Jim Cartar through MediaWiki message delivery (talk) 03:02, 6 April 2014 (UTC)
Backlog drive[edit]
Hello SaltedCracker,
WikiProject Orphanage is holding a month long Backlog Elimination Drive to de-orphan articles which have orphan tags!
The goal is to eliminate the backlog of orphan articles. There are currently 123758 articles which have orphan tags. The drive is running from April 12, 2014 to May 12, 2014.
Awards will be given out for all editors participating in the drive in the form of barnstars at the end of the drive. To add your name in the participants list click here.
So start de-orphaning articles! Click here to see the list of articles need de-orphaning. Visit Suggestions for how to de-orphan an article to know more!


text:
- App for Vine Videos HD
- Bane Voice Changer
- BimboBooth
- Keyboard Skins - Color Keyboards
- 【365 Birthday Fortune】My horoscope "destiny/love/money"
- Class Trip Crush
- Dreamy Days in West Tokyo
- MxTube for YouTube
- Monogram Lite
- Tap Fiction
- voybien
- Color Letter - Find Out Letter O In Letters Q Quickly
- San Francisco Olympians V: The Monster Ball
BLE_Pedo 1.0
The "Download" link for BLE_Pedo 1.0 directs you to the iTunes AppStore, where you have to continue the download process.You must have an iTunes account to download the application. This download link may not be available in some countries.
More in Utilities - for BLE_Pedo 1.0
More by lin cheng - for BLE_Pedo 1.0


text:
Look of the Day: Hand Sewn
by Fashion 19 Reactions 0 Shares Print
This hand sewn dress is a true inspiration to all Project Runway wannabes. Inspired by upper east side style maven, Blair Waldorf, Cherylish whipped up this fabulous frock and completed the look with classy pearls, black stockings, and booties.
Here's what she has on:
- Dress: Handmade
- Tights: Hue
- Boots: Nine West
Congrats to Cherylish!
Everyone else, submit your looks and I might feature you on FabSugar! If you live overseas and have a Fab outfit to share, join the Overseas Fashionistas Group, to submit a Look in this group learn how to post a blog.
Project Runway
Zari 6 years
yeah,someething that i would really love to wear!hats off!
audreyxoxo 6 years
i love that dress. if she sold it, i would buy it
leeluvfashion 6 years
So chic!!!!
leeluvfashion 6 years
So chic!!!!
magalaya 6 years
Oh wow, awesome look! I especially love the dress, totally would buy it if I saw something like that in a store, great job!
Cherylish 6 years
Oh my gosh! Thanks! All these people started saying congrats to me and I had no idea what they were talking about! Glad you liked my dress! It was made from a Vogue pattern that I altered.
Marni7 6 years
Very nice! Good Job :-)
Marni7 6 years
Very nice! Good Job :-)
emalove 6 years
Oh wow, you're very talented! Great job!
nillawafer1983 6 years
Congrats Cheryl!!!!!!!! Haha I was just reading FabSugar and like literally SHRIEKED when I saw your pic on the front page!!!!!!
mcollazo 6 years
Awesome dress, very talented. I wish I had the skills to make my own clothes
jspark 6 years
There's no green in the look of the day! Looks like someone needs to be pinched... Fab!
jspark 6 years
There's no green in the look of the day!Looks like someone needs to be pinched... Fab!
Shopaholichunny 6 years
FAB job! You have talent hun! :)
DCStar 6 years
Cherylish, you made that?? It's fabulous...you've got skills congrats!
nyaradzom2001 6 years
Wow, you are seriously talented!!1
Lovely_1 6 years
Wow! Great job! You look awesome :)
aimeeb 6 years
Kudos to you!
aimeeb 6 years
Kudos to you!
Link Love
- The British Fashion Award nominees are in, and both girls made the cut — Style.com
- All the cool girls are carrying the new It bag — Who What Wear
- Guess which model is pregnant now?! — HuffPost Style
- How to dress for the occasion it's not easy to dress for — InStyle
- What's behind the crazy fashion trends in Tokyo? — The Cut
- A lesson in Halloween costumes from the Pinterest pros — Racked
- That old neckline you loved so much is back — Stylelist
- Will American Apparel get a new look? — Fashionista
- Your classic jeans require more effort than you think — The Fashion Spot


text:
Frozen water pipes break, force schools to close
Updated On: Jan 08 2014 04:44:16 PM CST
The blistering cold continues to cause problems for schools across the region.
Several schools were forced to dismiss early or close yet again Wednesday after frozen pipes burst throughout buildings.
Workers at the Community UCC Preschool in St. Lawrence, Berks Co., said classes were in session when a frozen pipe burst in the ceiling, sending students home immediately.
"We heard a little bit of a banging, and the pipes here in the foyer, the water started coming down," said Dawn Barzd, Community UCC Preschool.
Barzd was working in the preschool's main office on the lower level of the church on St. Lawrence Avenue when the pipe burst. She and others rushed to turn off the water.
"And we have over 100 little kids here who need to use the bathroom, so we needed to close the school immediately, and we closed the PM classes, as well," Barzd said.
The preschool called in plumber Ryan Reifsnyder, who said it was one of many calls he's received this week for freeze-ups.
"If you're lucky enough, it freezes and it doesn't burst, you know, if you're lucky," Reifsnyder said. "But as far as once they split from the pressure of the ice expanding, like I said, once it thaws out, it's going to leak."
It was the same problem discovered in two different classrooms at the Riverview Christian Early Learning Center on Stoudts Ferry Bridge Road in Muhlenberg Township early Wednesday, forcing the Rev. John Letterman to call off school.
"It's an unfortunate incident, but there's really nothing we could do," Letterman said.
It's a burden that he said not only hits the school hard financially but serves as an inconvenience for staff, students and their families.
"I just feel bad for the parents, and hopefully we can get everything straightened out and put everything back together for tomorrow," Letterman said.
Both Riverview and Community UCC are scheduled to reopen their doors to students on Thursday.
Copyright 2014 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Fire destroys pizza shop on Main Street in Nazareth
Teacher's aide charged in alleged driving rampage near school
Texas man charged in shooting death of Lower Macungie man
Blood-covered suspect arrested in shooting of man in Reading
Nurse refuses Ebola quarantine
Humane Society puts out urgent plea for donations
Suicidal teen reported missing
Possible sighting of Eric Frein reported in Poconos
Life Lessons: Hidden health benefits of honey
Babysitter charged with attempting to murder child in her care


text:
|By Business Wire
Article Rating:
|June 4, 2014 10:18 AM EDT
Shoals Technologies Group, the leading manufacturer of photovoltaic (PV) Balance of Systems (BoS) components, and Synapse Wireless, an emerging leader in wireless solutions that empower the Internet of Things (IoT), building on their long partnership in the field of solar energy, today introduced SolarSNAP, an innovative monitoring tool that provides live-access monitoring of the installation of solar technology fields.
Solar Energy technology is defined in two parts, photovoltaic modules and "Balance of Systems." The Balance of Systems includes a combination of components, labor, assembly and installation. As PV module pricing continues to decline, the solar energy industry is focused on reducing costs in the Balance of Systems, in order to better compete with other types of energy production. The ability to more closely monitor and measure the installation of solar technology contributes to these savings by bringing solar energy on-line faster and more cost effectively than ever.
The SolarSNAP Installation Tool
SolarSNAP is a monitoring tool created by Shoals and Synapse Wireless to increase speed-to-revenue for solar field owners by providing real-time data as the solar technology is installed. SolarSNAP monitors and gives owners visibility into labor costs and contractor effectiveness, increasing the accuracy of time-to-commissioning forecasts. It provides information on the entire solar energy commissioning process, down to the string level (between PV modules). With integration into Synapse's cloud-based SNAPShot platform, and a choice of fixed or mobile solutions, SolarSNAP provides live access to installation data from anywhere, at any time.
SolarSNAP Launches at InterSolar Europe Conference
"InterSolar brings companies from around the world together with the ultimate goal of increasing solar adoption for everyone. We're delighted to announce our new SolarSNAP solar installation tool here, to show existing and potential solar field owners how they can increase their return on investment with this technology," said Dean Solon, President & CEO, Shoals Technologies Group.
"SolarSNAP is the latest in a long line of wireless innovations developed by the Synapse Wireless and Shoals partnership. From one-of-a-kind wireless ARC fault detection, or our user-friendly SNAPShot Solar Field Install tool, to our announcement today of SolarSNAP, our goal is to provide smart solutions that increase safety and efficiency, reduce time-to-market, and ultimately increase profitability for our users," said Key Foster, CEO, Synapse Wireless.
Synapse Wireless and Shoals Technologies Group will be exhibiting at Hall A3, Booth 290 at the InterSolar Europe Conference, being held June 4-6 at Messe München.
About Shoals Technologies Group
Shoals Technologies Group is a leading manufacturer of balance of systems solutions. Consistently providing customers with innovative designs and superior quality products has directly contributed to the exponential growth since its founding in 1996. With over 15 GW+ of BOS products deployed globally, Shoals maintains a diverse portfolio of PV balance of systems products, including, combiner/re-combiner boxes, disconnecting combiner boxes, custom harnessing solutions, junction boxes, PV wire, in-line fuses, racking and PV monitoring solutions.
About Synapse Wireless, Inc.
Synapse Wireless, Inc. delivers proven, scalable M2M connectivity solutions designed to revolutionize business. Built on its award-winning SNAP® wireless mesh network operating system, Synapse brings game-changing analytics that matter. Synapse Wireless solutions are deployed on enterprise-class platforms, distributing intelligence to the edge of its customers' networks. Synapse is a subsidiary of McWane, Inc.
The Internet of Things will greatly expand the opportunities for data collection and new business models driven off of that data. In her session at Internet of @ThingsExpo, Esmeralda Swartz, CMO of MetraTech, will discuss how for this to be effective you not only need to have infrastructure and operational models capable of utilizing this new phenomenon, but increasingly service providers will need to convince a skeptical public to participate. Get ready to show them the money! Speaker Bio: Esmeralda Swartz, CMO of MetraTech, has spent 16 years as a marketing, product management, and busin...
Oct. 24, 2014 09:30 PM EDT Reads: 1,091
Samsung VP Jacopo Lenzi, who headed the company's recent SmartThings acquisition under the auspices of Samsung's Open Innovaction Center (OIC), answered a few questions we had about the deal. This interview was in conjunction with our interview with SmartThings CEO Alex Hawkinson. IoT Journal: SmartThings was developed in an open, standards-agnostic platform, and will now be part of Samsung's Open Innovation Center. Can you elaborate on your commitment to keep the platform open? Jacopo Lenzi: Samsung recognizes that true, accelerated innovation cannot be driven from one source, but requires a...
Oct. 23, 2014 11:45 PM EDT Reads: 2,591
SYS-CON Events announced today that Red Hat, the world's leading provider of open source solutions, will exhibit at Internet of @ThingsExpo, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Red Hat is the world's leading provider of open source software solutions, using a community-powered approach to reliable and high-performing cloud, Linux, middleware, storage and virtualization technologies. Red Hat also offers award-winning support, training, and consulting services. As the connective hub in a global network of enterprises, partners, a...
Oct. 23, 2014 11:30 PM EDT Reads: 1,647
P2P RTC will impact the landscape of communications, shifting from traditional telephony style communications models to OTT (Over-The-Top) cloud assisted & PaaS (Platform as a Service) communication services. The P2P shift will impact many areas of our lives, from mobile communication, human interactive web services, RTC and telephony infrastructure, user federation, security and privacy implications, business costs, and scalability. In his session at Internet of @ThingsExpo, Robin Raymond, Chief Architect at Hookflash Inc., will walk through the shifting landscape of traditional telephone a...
Oct. 23, 2014 08:15 PM EDT Reads: 1,537
SYS-CON Events announced today that Matrix.org has been named "Silver Sponsor" of Internet of @ThingsExpo, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Matrix is an ambitious new open standard for open, distributed, real-time communication over IP. It defines a new approach for interoperable Instant Messaging and VoIP based on pragmatic HTTP APIs and WebRTC, and provides open source reference implementations to showcase and bootstrap the new standard. Our focus is on simplicity, security, and supporting the fullest feature set.
Oct. 23, 2014 08:00 PM EDT Reads: 1,655
BSQUARE is a global leader of embedded software solutions. We enable smart connected systems at the device level and beyond that millions use every day and provide actionable data solutions for the growing Internet of Things (IoT) market. We empower our world-class customers with our products, services and solutions to achieve innovation and success. For more information, visit www.bsquare.com.
Oct. 23, 2014 08:00 PM EDT Reads: 1,588
How do APIs and IoT relate? The answer is not as simple as merely adding an API on top of a dumb device, but rather about understanding the architectural patterns for implementing an IoT fabric. There are typically two or three trends: Exposing the device to a management framework Exposing that management framework to a business centric logic • Exposing that business layer and data to end users. This last trend is the IoT stack, which involves a new shift in the separation of what stuff happens, where data lives and where the interface lies. For instance, it's a mix of architectural style...
Oct. 23, 2014 07:45 PM EDT Reads: 1,607
SYS-CON Events announced today that SOA Software, an API management leader, will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. SOA Software is a leading provider of API Management and SOA Governance products that equip business to deliver APIs and SOA together to drive their company to meet its business strategy quickly and effectively. SOA Software's technology helps businesses to accelerate their digital channels with APIs, drive partner adoption, monetize their assets, and achieve a...
Oct. 23, 2014 06:15 PM EDT Reads: 1,634
From a software development perspective IoT is about programming "things," about connecting them with each other or integrating them with existing applications. In his session at @ThingsExpo, Yakov Fain, co-founder of Farata Systems and SuranceBay, will show you how small IoT-enabled devices from multiple manufacturers can be integrated into the workflow of an enterprise application. This is a practical demo of building a framework and components in HTML/Java/Mobile technologies to serve as a platform that can integrate new devices as they become available on the market.
Oct. 23, 2014 06:15 PM EDT Reads: 1,588
SYS-CON Events announced today that Utimaco will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Utimaco is a leading manufacturer of hardware based security solutions that provide the root of trust to keep cryptographic keys safe, secure critical digital infrastructures and protect high value data assets. Only Utimaco delivers a general-purpose hardware security module (HSM) as a customizable platform to easily integrate into existing software solutions, embed business logic and build s...
Oct. 23, 2014 05:45 PM EDT Reads: 1,554
Connected devices are changing the way we go about our everyday life, from wearables to driverless cars, to smart grids and entire industries revolutionizing business opportunities through smart objects, capable of two-way communication. But what happens when objects are given an IP-address, and we rely on that connection, sometimes with our lives? How do we secure those vast data infrastructures and safe-keep the privacy of sensitive information? This session will outline how each and every connected device can uphold a core root of trust via a unique cryptographic signature – a "bir...
Oct. 23, 2014 05:00 PM EDT Reads: 1,454
Internet of @ThingsExpo Silicon Valley announced on Thursday its first 12 all-star speakers and sessions for its upcoming event, which will take place November 4-6, 2014, at the Santa Clara Convention Center in California. @ThingsExpo, the first and largest IoT event in the world, debuted at the Javits Center in New York City in June 10-12, 2014 with over 6,000 delegates attending the conference. Among the first 12 announced world class speakers, IBM will present two highly popular IoT sessions, which will take place November 4-6, 2014 at the Santa Clara Convention Center in Santa Clara, Calif...
Oct. 23, 2014 01:00 PM EDT Reads: 1,617
Almost everyone sees the potential of Internet of Things but how can businesses truly unlock that potential. The key will be in the ability to discover business insight in the midst of an ocean of Big Data generated from billions of embedded devices via Systems of Discover. Businesses will also need to ensure that they can sustain that insight by leveraging the cloud for global reach, scale and elasticity.
Oct. 22, 2014 09:00 PM EDT Reads: 1,467
WebRTC defines no default signaling protocol, causing fragmentation between WebRTC silos. SIP and XMPP provide possibilities, but come with considerable complexity and are not designed for use in a web environment. In his session at Internet of @ThingsExpo, Matthew Hodgson, technical co-founder of the Matrix.org, will discuss how Matrix is a new non-profit Open Source Project that defines both a new HTTP-based standard for VoIP & IM signaling and provides reference implementations.
Oct. 22, 2014 01:15 PM EDT Reads: 1,584
SUNNYVALE, Calif., Oct. 20, 2014 /PRNewswire/ -- Spansion Inc. (NYSE: CODE), a global leader in embedded systems, today added 96 new products to the Spansion® FM4 Family of flexible microcontrollers (MCUs). Based on the ARM® Cortex®-M4F core, the new MCUs boast a 200 MHz operating frequency and support a diverse set of on-chip peripherals for enhanced human machine interfaces (HMIs) and machine-to-machine (M2M) communications. The rich set of periphera...
Oct. 21, 2014 08:30 PM EDT Reads: 1,645
SYS-CON Events announced today that Aria Systems, the recurring revenue expert, has been named "Bronze Sponsor" of SYS-CON's 15th International Cloud Expo®, which will take place on November 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Aria Systems helps leading businesses connect their customers with the products and services they love. Industry leaders like Pitney Bowes, Experian, AAA NCNU, VMware, HootSuite and many others choose Aria to power their recurring revenue business and deliver exceptional experiences to their customers.
Oct. 21, 2014 06:00 PM EDT Reads: 1,549
The Internet of Things (IoT) is going to require a new way of thinking and of developing software for speed, security and innovation. This requires IT leaders to balance business as usual while anticipating for the next market and technology trends. Cloud provides the right IT asset portfolio to help today's IT leaders manage the old and prepare for the new. Today the cloud conversation is evolving from private and public to hybrid. This session will provide use cases and insights to reinforce the value of the network in helping organizations to maximize their company's cloud experience.
Oct. 21, 2014 05:15 PM EDT Reads: 1,620
The Internet of Things (IoT) is making everything it touches smarter – smart devices, smart cars and smart cities. And lucky us, we're just beginning to reap the benefits as we work toward a networked society. However, this technology-driven innovation is impacting more than just individuals. The IoT has an environmental impact as well, which brings us to the theme of this month's #IoTuesday Twitter chat. The ability to remove inefficiencies through connected objects is driving change throughout every sector, including waste management. BigBelly Solar, located just outside of Boston, is trans...
Oct. 21, 2014 09:00 AM EDT Reads: 1,801
SYS-CON Events announced today that Matrix.org has been named "Silver Sponsor" of Internet of @ThingsExpo, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Matrix is an ambitious new open standard for open, distributed, real-time communication over IP. It defines a new approach for interoperable Instant Messaging and VoIP based on pragmatic HTTP APIs and WebRTC, and provides open source reference implementations to showcase and bootstrap the new standard. Our focus is on simplicity, security, and supporting the fullest feature set.
Oct. 20, 2014 11:45 PM EDT Reads: 1,505
Predicted by Gartner to add $1.9 trillion to the global economy by 2020, the Internet of Everything (IoE) is based on the idea that devices, systems and services will connect in simple, transparent ways, enabling seamless interactions among devices across brands and sectors. As this vision unfolds, it is clear that no single company can accomplish the level of interoperability required to support the horizontal aspects of the IoE. The AllSeen Alliance, announced in December 2013, was formed with the goal to advance IoE adoption and innovation in the connected home, healthcare, education, aut...
Oct. 20, 2014 11:15 PM EDT Reads: 1,880


text:
News from WTOP
News from the AP
Mike Causey
Shows & Panels
Shows & Panels
- The 2014 Big Picture on Cyber Security
- AFCEA Answers
- American Readiness: Renewable Power and Efficiency Technologies
- Ask the CIO
- Building the Hybrid Cloud
- CDWG/NetApp
- Connected Government: How to Build and Procure Network Services for the Future
- Continuing Diagnostics and Mitigation: Discussion of Progress and Next Steps
- Delivering the Digital Government Mission
- Federal Executive Forum
- Federal News Radio's National Cyber Security Awareness Month Special Panel Discussion
- Federal Tech Talk
- The Future of Government Data Centers
- The Future of IT: How CIOs Can Enable the Service-Oriented Enterprise
- Government Perspectives on Mobility and the Cloud
- The Intersection: Where Technology Meets Transformation
- Maximizing ROI Through Data Center Consolidation
- Mitigating Insider Threats in Virtual & Cloud Environments
- Modern Mission Critical Series
- The New Generation of Database
- Reimagining the Next Generation of Government
- Targeting Advanced Threats: Proven Methods from Detection through Remediation
- Transformative Technology: Desktop Virtualization in Government
- The Truth About IT Opex and Software Defined Networking
- Air Traffic Management Transformation Report
- Cloud First Report
- General Dynamics IT Enterprise Center
- Gov Cloud Minute
- Government in Technology Series
- Homeland Security Cybersecurity Market Report
- National Cybersecurity Awareness Month
- Technology Insights
- The Cyber Security Report
- The Next Generation Cyber Security Experts
Shows & Panels
CDC cuts red tape and wins awards doing it
We meet the CDC fed awarded for her "spirit of innovation and get it done' mindset" - Nancy Norton, a contracting officer and team leader for the Centers for Disease Control and Prevention's Procurement and Grants Office.
Bringing government to the people
Janice Nall, director of the Division of eHealth Marketing at the CDC, says government needs to be where people are getting their information.
Agencies engage citizens with social collaboration
Agencies across the federal government are embracing the tools of social collaboration to become more accessible to citizens. An IT industry group that includes many federal IT officials heard from three of the top government experts in the field.
COOP lights a fire under telework
Telework proves its worth, even in the planning stages of an emergency.
Connecting the health and environment
Federal Agencies Using CONNECT
Tall order submitted for GPO's Swine Flu flier
The Government Printing Office makes it possible to put H1N1 virus information literally into the hands of those who need it most.


text:
AN OXFORD pub shut its doors for the last time on Saturday after recent incidents involving violence and drug use.
The Nelson, in Between Towns Road, Cowley, has been serving customers in its current incarnation since the early 1960s, when it moved to allow the Templars Square shopping centre to be built.
It previously traded for many years in Hockmore Street.
But The Nelson had its last trading day on Saturday, before being officially shut from today.
Manager David Brewerton said he was told by the owner, the Spirit Pub Company, almost two months ago that it was calling last orders.
He said: "Spirit group got in touch at the end of June. They said they were going through the council and police without me and said I had to get out of the pub.
"They served me a notice saying I had to get out and if I did get out, I would get my deposit back.
"We will be closing today. As far as I know, no one will take the pub over."
Oxford City Council has confirmed that it was not involved in the closure and the Spirit Pub Company has not provided an explanation as to why the pub is shutting.
In February last year, a man was arrested on suspicion of affray after a brawl at the pub.
In May this year, police found substances believed to be illegal drugs on the premises.
But Mr Brewerton said things had improved in recent years.
He said: "When I took the pub over we had very, very high drug readings and there was a lot of violence.
"Through barring people and a zero-tolerance policy on drug use in the pub, we reduced and got the drug use right down.
"Some people would probably say it's a good thing to see the pub go, but the regulars were always very friendly in there. I have never had any problem with them.
"I'm concerned for the four staff in the pub, who have nowhere to go now.
He added: "And our regulars have nowhere to go. They have lost their meeting place."
Seventy-five-year-old David Lock worked as a barman at The Nelson in the 1970s and 1980s.
He said: "I was very surprised when I heard it was closing down.
"I worked there part-time for years, about 10 or 15 years back in the 1970s and 1980s.
"It was a lovely family pub, good landlord and landlady, and her food was absolutely spot on.
"At dinner hour, when the men came out of the factories, we would have the food waiting for them, because they ordered it the day before.
"It was always busy. You couldn't get them out at night. I loved working there."
A spokesman for the Spirit Pub Company said: "We can confirm The Nelson will be closed again on an agreed surrender on September 1."
He did not reply to the Oxford Mail's questions about why the company was shutting the pub, nor provide a response to Mr Brewerton's comments.
Oxford City Council's director of community services, Tim Sadler, said the council had not ordered the closure.
He said: "The council has not requested the pub to surrender its licence.
"No application has been made to the council to surrender the licence by Spirit Group."
Thames Valley Police declined to comment.
- Do you want alerts delivered straight to your phone via our WhatsApp service? Text NEWS or SPORT or NEWS AND SPORT, depending on which services you want, and your full name to 07767 417704. Save our number into your phone's contacts as Oxford Mail WhatsApp and ensure you have WhatsApp installed.
Send your Letter to the Editor
11:20am Monday 28th July 2014
What do you think? We welcome letters from our readers on a wide variety of subjects and you can send us a letter through the blue headline above.
Our top stories
Cyclists warned: Don't be dimwits
9:00am Saturday 25th October 2014
BIKE safety campaigners have warned that cyclists are risking their lives, after an Oxford Mail survey found more than half of them were riding without lights.
FOOTBALL: Rose wants to keep Oxford United climbing
9:30am Saturday 25th October 2014
Danny Rose is targeting a move into mid-table today as Oxford United visit Carlisle United in search of a third win in eight days.
Shhh... silent film is a reel hit with movie buffs
9:30am Saturday 25th October 2014
FILM buffs were given a taste of how movies used to be watched as they turned out for a silent screening in Witney.
Update: Oxford University student Isobel Priest is found safe and well
8:49am Saturday 25th October 2014
Police have said the 21-year-old Oxford University student who was reported missing has been found safe and well.
Runaway emu killed after crash with car
8:40am Saturday 25th October 2014
AN EMU escaped from a garden in Boar's Hill and died after being hit by a car, Thames Valley Police said yesterday.
Off and running for entry to our OX5 extravaganza
8:30am Saturday 25th October 2014
THE starting gun has been fired for next year's Oxford Mail OX5 Run as places open for runners in the fundraising extravaganza.