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Winnipeg Free Press - ONLINE EDITION
Katz goes on offensive in TV debate
Incumbent Mayor Sam Katz used the first televised debate of the 2010 civic election campaign to accuse challenger Judy Wasylycia-Leis of being hypocritical about government transparency.
Since late August, Wasylycia-Leis has been demanding the mayor release more details about the city's wastewater-management contract with Veolia Canada, claiming the 30-year deal is indicative of a culture of secrecy at city hall.
Katz has responded by demanding the former Winnipeg North MP release details of her expenses when she served in Ottawa – and Wasylycia-Leis has dismissed that move as a deflection.
But tonight, Katz attacked his opponent's record on government transparency when she served as a member of Howard Pawley's Manitoba NDP government during the 1980s.
During an all-candidates' debate at the Franco-Manitoban Cultural Centre, televised by Shaw Cable, Katz lambasted Wasylycia-Leis for "sitting on" Manitoba's freedom-of-information legislation for more than two years after the Pawley government passed it in 1985.
That legislation was enacted by Gary Filmon's Progressive Conservative government in 1988. Ombudsman Manitoba attributes the delay to records-management upgrades.
Wasylycia-Leis dismissed the criticism and altered a phrase made famous by former Canadian Prime Minister Brian Mulroney to fire back at Katz for refusing to share more details of the Veolia contract.
"You had a choice, my friend," said Wasylycia-Leis, aping Mulroney's famous "you had an option, sir" zinger from the 1984 federal-election debate with former Liberal leader John Turner.
Katz maintains the city has not finished writing the Veolia contract, which calls for the environmental consulting firm to design, build and possibly manage $661 million worth of upgrades to two city sewage-treatment plants.
Some city officials are concerned about the scope of the deal and say it may include hundreds of millions more in contracts. Katz suggested last night he was not aware of that.
The incumbent mayor also accused Wasylycia-Leis of being hypocritical about her "buy local" policy, claiming that his opponent has spent most of her advertising money on a Vancouver-based agency.
The agency in question, Now Communications, has a Winnipeg office as well as other branches in Toronto, Regina and Halifax.
The debate was also the first to feature Winnipeg's other two mayoral candidates: real-estate agents Rav Gill and Brad Gross.
Gill promised to eliminate and redevelop the CPR Winnipeg Yards. Gross criticized Katz for selling off the revenue-generating Winnipeg Square Parkade.
The debate was organized by Winnipeg Realtors. Shaw Cable intends to rebroadcast the 85-minute event.
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Saurabh is a huge fan of IE's cool attitude and the way it handles criticism without changing the way it works.
"Till yesterday I was thinking that Supreme Court is an independent entity when they pulled up BJP govt on black money issue, but today I am saddened to say even it is working in collusion with BJP," Kejriwal declared.
"There is so much of fuss over the names of Swiss Bank account holders having billions of dollars being made public, I too am a citizen of the same country and thus deserve similar treatment," said the pickpocket pointing to the small gain accruing to him for his petty crime.
After Indian troops' recent blocking of attempts by the China's People's Liberation Army (PLA) soldiers to construct a road in the Asaphila region of Arunachal Pradesh, the Chinese have applied to the Indian government for construction of this road under the FDI route.
"He sits daily in his office with a staff of 5 people and sells properties faster than he can count till 10," disclosed boy's 25 year old personal secretary.
With the help of his idea, Vineet has successfully managed to bring down daily count from 12 cigarettes to 8 cigarettes.
Earlier, Anoop and his three friends who live in Mumbai itself, were planning to take a roadtrip of a lifetime, but things didn't work out the way they were expecting.
Mr. Dhanraj Singh Kaala, a successful businessman and neighbour of one of the businessmen named in the list, while is relieved that he has not been named but is facing predicament of a divorce, after a long marriage of thirty years, for reasons best explained by his wife.
"In India, we have time and again seen an indirect correlation between the critics' ratings and the box office performance of the films. People tend to confuse good rated films with some intellectual and sensible stuff and keep away from cinema halls," Farah explained how critics hampered HNY's collections.
The top brass of the leading IT firms have held a joint press meeting to explain this move and have pointed to following advantages of hiring Jihadis: -


text:
The governors of New Jersey and New York say they're issuing a mandatory quarantine for travelers.
A man admitted driving a car onto Oklahoma's state Capitol grounds overnight and into a disputed granite monument.
A Virginia medical examiner has identified human remains found last week as those of missing student.
The gunman who shot and killed a soldier once complained that a Vancouver mosque he attended was too liberal.
An American doctor, who became the first person to be diagnosed with Ebola in New York, is in stable condition.
Craig Spencer, a Doctors Without Borders physician, tested positive for the Ebola virus.
According to the reports the shooting occurred in the school cafeteria of Marysville-Pilchuck High School.
A gunman who stormed Canada's parliament after killing a soldier at a nearby war memorial was a petty criminal.
Secretary of State John Kerry said on Friday that it was too early to discuss cutting the number of US troops stationed in Asia and South Korea, amid increased tensions on the heavily guarded peninsula. The top US diplomat insisted before any such moves could happen North Korea must first show a serious commitment to […]
Peru's electoral law allows for tied races to be decided by a coin toss.
The first person diagnosed with Ebola on U.S. soil flew from Liberia to Texas and later died in a Dallas hospital.
Canadian police has now conceded that there was just one gunman in Ottawa attack.
President Barack Obama condemned the shootings in Canada as "outrageous acts."
US President Barack Obama greeted Hindus, Jains, Sikhs and Buddhists across the world on the occasion of Diwali.
The White House has cautioned against making assumptions about Obama's changes to US immigration rules.
All travelers who come into the US from three Ebola-stricken West African nations will now be monitored.
Goldman Sachs attacked expert evidence offered by attorneys for ex-female employees in a sex discrimination lawsuit.
US health officials are setting up a network of about 20 go-to hospitals to handle the care of an Ebola patient.
The American was arrested and held for nearly six months in North Korea for leaving a Bible at a nightclub.
US and Canadian put their air defence on heightened alert following a shooting in Canada's parliament.
Mexico says 19 suspects died in three nearly simultaneous confrontations just across the border from Texas.
An American man, who was detained by North Korea, had a teary reunion with his family in Ohio, USA.
Instead of finding the 43, authorities are asking "Who are the 28?"
A young woman was voting next to Obama when her boyfriend decided to make a wise crack.
An Omaha hospital says an American video journalist is free of Ebola and will be released soon. The Nebraska Medical Center said Tuesday afternoon that Ashoka Mukpo's blood tested negative for the virus. He will be allowed to leave a biocontainment unit Wednesday. Mukpo said in a statement that recovering from Ebola "is a truly […]
Eighty-eight former students were sexually molested by a Franciscan friar who worked as an athletic trainer.
A mentally ill British man accused of trying to set up a terrorist training camp in Oregon has pleaded not guilty.
FBI is investigating the possibility that three girls were trying to travel to Syria to join ISIS extremists.
Senior US officials are considering an Iraqi request for more American military advisers.
The United States issued stringent new protocols on Monday for health workers treating Ebola victims, directing medical teams to wear protective gear that leaves no skin or hair exposed to prevent medical workers from becoming infected. The new guidelines from the US Centers for Disease Control and Prevention in Atlanta come as 43 people who were […]
The Pentagon said that US air strikes has helped to keep Islamic State militants from taking Kobani.
On Thursday, most of North America will have prime viewing of a partial solar eclipse.
Everyone coming to US from three West African countries at the center of the Ebola outbreak will now be screened.
Indian medical researcher Vikram Patel has been awarded the US-based Sarnat Prize.
Obama said a few recent events have raised the anxiety level of the people.
The US and China pledged Saturday to overcome mistrust, manage their differences and cooperate.
Raji is a Member of the President's Commission on White House Fellowships, a position she has held since 2013.


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I wasn't officially diagnosed with GAD , but reading the instructions... and uses for the drugs that was prescribed for me , and look at my history , I would definitely say that I have it ... any way to confirm ... my doctor has given me " Duloxetine " ... has it been any good for any of you ... if not ..then what is the most effective drug that I can take ?
Generalized Anxiety Disorder - How good is the " Duloxetine " & " Adival " for GAD ?
- Posted:
- 20 Aug 2012 by leokan
- Topics:
- anxiety, generalized anxiety disorder, duloxetine
Added 21 Aug 2012:
and what is the Average period-time that i should keep taking it >>>???
Answers (1)
21 Aug 2012
Duloxetine works very well for some people. There are many medicines similar to duloxetine and it is not a one size fits all sort of deal. Rather it is a trial and error process finding the medication that works for you. Can take awhile to figure out, but well worth the effort once you do.
How common is it " Duloxetine " ... and what is the next best thing that I could try , currently my doctor has prescribed these for me ( Merlit , Adival )
Duloxetine is used often in the US for both depression/ anxiety and for neuropathic pain. The other two medication I am not familiar with as they are not available in the US.
Further Information
- Duloxetine Information for Consumers
- Duloxetine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Duloxetine (detailed)
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I have panic attack and anxiety and I start cymbalta(duloxetine) tell me this capsule is good for?
... panic attack.plz reply.i worried about this plz help me and choose a good medicine for this problem... plz reply... ...
2 answers • 27 Nov 2010
I am currently coming off citalopram and have been given duloxetine but Im extremely worried about?
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Winnipeg Free Press - PRINT EDITION
Critics of Big in Japan go overboard
Dear Editor
As a naturalized Canadian citizen of Polish and British ancestry who has the highest respect for Asian culture, particularly the historical cultures of China and Japan, to the extent that I have endeavoured to acquire even a rudimentary knowledge of their languages, I find Jenny Heijun Wills' article, WAG and the peril of yellowface (Free Press, Feb. 12) to be overreactive.
In the unlikely contingency that a cultural institution in Japan were to sponsor a Canadian-themed event, and were to use phrases such as, "Crawl out of your igloo, grab your tuque, your hockey stick and your maple leaf boxer shorts, harness up the dog team and mush on down to our fundraiser," I wonder if Canadians of any ethnic background living in Japan would be grossly offended.
Heijun Wills writes that "intention does not matter," but I truly doubt that any intention of ridicule or "cultural tourism" was present in the Winnipeg Art Gallery's choice of words.
If we are to scorn "cultural appropriation," then we should cast a cold eye on much of the decorative arts of 18th-century Europe, particularly France, where the vogue of Chinoiserie, the imitation of Chinese decorative motifs, had a sweeping influence on everything from interior design to textiles and porcelain.
In the same century, the gorgeous Imari porcelains of Japan inspired the emulation of the great English pottery manufacturers, Wedgwood, Spode, Chelsea and Derby, to name only four.
In the latter half of the 19th century, the similar phenomenon of Japonisme engulfed Europe, especially after the Japanese pavilion proved to be the most popular venue at the Paris Exposition Universelle of 1867, and without the influence of Japanese art, we might not have some of the most compelling works of Vincent van Gogh.
Do Heijun Wills's objections to "decontextualized images" mean that henceforth, if Winnipeg's outstanding Gilbert and Sullivan Society wants to stage The Mikado, it will be necessary to eliminate all references to Japan, or alternatively, issue a "we don't mean to offend anyone" apology? Will the Manitoba Opera Association be placed in the same position if they want to present Puccini's Madame Butterfly?
To carry the factor of racialism further into the equation, should a concert pianist have to apologize before including Debussy's Golliwog's Cakewalk in a recital, because, for readers who may be too young to remember, a golliwog was a blackface doll dressed in the blue jacket and red and white striped trousers of a performer in a Kentucky minstrel show?
Unfortunately, an attempt at humour can, unintentionally, backfire and hit a sensitive nerve, as I conjecture was the case with Heijun Wills, but my own reaction to her article is best encapsulated in a quotation of which, since Heijun Wills is a professor of English, it would be superfluous for me to cite the source: "The lady doth protest too much, methinks."
David Rozniatowski
Republished from the Winnipeg Free Press print edition February 15, 2014 A17
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... and hydrochlorothiazide that lead to hair loss in older women?
High Blood Pressure - Are there known interactions among losartan. lovastatin, amlodipine, atenolol?
- Posted:
- 23 Mar 2010 by mdclark4498
- Topics:
- high blood pressure, anxiety, amlodipine, atenolol, hydrochlorothiazide, losartan, lovastatin, blood disorders
|Question is Closed
|Report Mark as Favorite
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When I used the interactions checker I did not see any discussion of hair loss or --for that matter--- older females' specific experiences.
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Should amlodipine and losartan be taken if their both for high blood pressure?
he takes 100MG of Losartan and 10 MG of amlodipine,but they are both for high blood pressure.
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Publications (310)1637.7 Total impact
Article: Rifaximin Has a Marginal Impact on Microbial Translocation, T-cell Activation and Inflammation in HIV-Positive Immune Non-responders to Antiretroviral Therapy - ACTG A5286.The Journal of infectious diseases. 09/2014;
Article: sCD163 is associated with non-invasive measures of liver fibrosis in HCV- and HCV/HIV-infected womenHepatology 07/2014; · 12.00 Impact Factor
Article: Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication.[Show abstract] [Hide abstract]
ABSTRACT: Damage to the intestinal mucosa results in the translocation of microbes from the intestinal lumen into the circulation. Microbial translocation has been proposed to trigger immune activation, inflammation, and coagulopathy, all of which are key factors that drive HIV disease progression and non-HIV comorbidities; however, direct proof of a causal link is still lacking. Here, we have demonstrated that treatment of acutely SIV-infected pigtailed macaques with the drug sevelamer, which binds microbial lipopolysaccharide in the gut, dramatically reduces immune activation and inflammation and slightly reduces viral replication. Furthermore, sevelamer administration reduced coagulation biomarkers, confirming the contribution of microbial translocation in the development of cardiovascular comorbidities in SIV-infected nonhuman primates. Together, our data suggest that early control of microbial translocation may improve the outcome of HIV infection and limit noninfectious comorbidities associated with AIDS.The Journal of clinical investigation. 05/2014;
Article: A Randomized Controlled Trial of Palifermin (Recombinant Human Keratinocyte Growth Factor) for the Treatment of Inadequate CD4+ T-Lymphocyte Recovery in Patients with HIV-1 Infection on Antiretroviral Therapy.[Show abstract] [Hide abstract]
ABSTRACT: Poor CD4 lymphocyte recovery on antiretroviral therapy (ART) is associated with reduced function of the thymus. Palifermin (keratinocyte growth factor), by providing support to the thymic epithelium, promotes lymphopoiesis in animal models of bone marrow transplantation and graft-versus-host disease. In AIDS Clinical Trials Group A5212, a randomized, double-blind, placebo-controlled study, 99 HIV-infected patients on ART with plasma HIV-1 RNA levels ≤200 copies/mL for ≥6 months and CD4 lymphocyte counts <200 cells/mm were randomized 1:1:1:1 to receive once daily intravenous administrations of placebo or 20, 40, or 60 µg/kg of palifermin on 3 consecutive days. The median change in CD4 T-cell count from baseline to week 12 was not significantly different between the placebo arm [15 (-16, 23) cells/mm] and the 20-µg/kg dose [11 (2, 32) cells/mm], the 40-µg/kg dose [12 (-2, 25) cells/mm], or the 60-µg/kg dose arm [8 (-13, 35) cells/mm] of palifermin. No significant changes were observed in thymus size or in the number of naïve T cells or recent thymic emigrants. Palifermin in the doses studied was not effective in improving thymic function and did not raise CD4 lymphocyte counts in HIV-infected patients with low CD4 cell counts despite virologically effective ART.JAIDS Journal of Acquired Immune Deficiency Syndromes 05/2014; · 4.65 Impact Factor
Article: Soluble markers of inflammation and coagulation, but not T-cell activation, are predictors of non-AIDS-defining morbid events during suppressive antiretroviral treatment.[Show abstract] [Hide abstract]
ABSTRACT: Background. Defining the association of non-AIDS-defining events with inflammation and immune activation among HIV-infected persons who are virologically suppressed on antiretroviral therapy (ART) is critical to identifying interventions to decrease their occurrence.Methods. We conducted a case-control study of HIV-infected subjects virologically suppressed after 1 year of ART. Cases had a myocardial infarction, stroke, non-AIDS-defining cancer, serious bacterial infection or death. Controls were matched for age, sex, pre-ART CD4(+)T-cells and regimen. PBMC and plasma from the pre-ART, after 1 year of ART and pre-event time-points were analyzed for activated CD4(+)/CD8(+)T-cells, plasma interleukin-6 (IL-6), soluble tumor necrosis factor receptors (sTNFR)-I and -II, soluble CD14, kynurenine:tryptophan (K/T) ratio and D-dimer. Conditional logistic regression analysis was used to study the association between biomarkers and outcomes with adjustment for potential confounders.Results. Higher levels of IL-6, sTNFR-I and -II, K/T ratio and D-dimer at year 1 were associated with the occurrence of a non-AIDS event. Significant associations were also seen pre-ART and pre-event. Effects remained significant after controlling for confounders. T-cell activation was not significantly related to outcomes.Conclusion. Interventional trials to decrease non-AIDS-defining events among virologically suppressed HIV-infected persons should consider targeting the pathways represented by these soluble markers.The Journal of Infectious Diseases 05/2014; · 5.85 Impact Factor
Article: Human α-amylase present in lower genital tract mucosal fluid processes glycogen to support vaginal colonization by Lactobacillus.[Show abstract] [Hide abstract]
ABSTRACT: Lactobacillus colonization of the lower female genital tract provides protection from acquisition of sexually transmitted diseases including HIV and from adverse pregnancy outcomes. While glycogen in vaginal epithelium is thought to support Lactobacillus colonization in vivo, many Lactobacillus isolates cannot utilize glycogen in vitro. This study investigated how glycogen could be utilized by vaginal lactobacilli in the genital tract. Several Lactobacillus isolates were confirmed to not grow in glycogen, but did grow in glycogen breakdown products including maltose, maltotriose, maltopentaose, maltodextrins and glycogen treated with salivary α-amylase. A temperature-dependent glycogen-degrading activity was detected in genital fluids that correlated with levels of α-amylase. Treatment of glycogen with genital fluids resulted in production of maltose, maltotriose and maltotetraose, the major products of α-amylase digestion. These studies show that human α-amylase is present in the female lower genital tract and elucidates how epithelial glycogen can support Lactobacillus colonization in the genital tract.The Journal of Infectious Diseases 04/2014; · 5.85 Impact Factor
Article: Macrophage Inflammatory Markers Are Associated With Subclinical Carotid Artery Disease in Women With Human Immunodeficiency Virus or Hepatitis C Virus Infection.[Show abstract] [Hide abstract]
ABSTRACT: Infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV) may be associated with atherosclerosis and vascular disease. Macrophages are a major component of atherosclerotic plaque, and classically activated (M1) macrophages contribute to plaque instability. Our goal was to identify plasma biomarkers that reflect macrophage inflammation and are associated with subclinical atherosclerosis. We tested whether M1 macrophages produce galectin-3-binding protein in vitro. Then, we measured galectin-3-binding protein and the soluble macrophage biomarkers soluble cluster of differentiation 163 and soluble cluster of differentiation 14 in 264 participants in the Women's Interagency HIV Study. Women were positive for HIV, HCV, both, or neither (66 in each group, matched for age, race/ethnicity, and smoking status). Carotid artery disease was assessed by ultrasound measurement of right distal common carotid artery intima-media thickness, distensibility, and presence of atherosclerotic lesions (IMT>1.5 mm). Plasma galectin-3-binding protein was higher in HCV+ than HCV- women (P<0.01) but did not differ by HIV status. The 3 inflammatory macrophage markers were significantly correlated with each other and negatively correlated with cluster of differentiation (CD)4+ counts in HIV-infected women. We defined a macrophage score as 1, 2, or 3 biomarkers elevated above the median. In models adjusted for traditional risk factors, higher macrophage scores were significantly associated with increased atherosclerotic lesions and lower carotid distensibility. Receiver-operator curve analysis of lesions revealed that the markers added predictive value beyond traditional risk factors and C-reactive protein. The macrophage inflammatory markers galectin-3-binding protein, soluble cluster of differentiation 163, and soluble cluster of differentiation 14 are significantly associated with carotid artery disease in the setting of HIV and HCV infection.Arteriosclerosis Thrombosis and Vascular Biology 03/2014; · 6.34 Impact Factor
Article: A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects.[Show abstract] [Hide abstract]
ABSTRACT: HIV progression is characterized by immune activation and microbial translocation. One factor that may be contributing to HIV progression could be a dysbiotic microbiome. We therefore hypothesized that the GI mucosal microbiome is altered in HIV patients and this alteration correlates with immune activation in HIV. 121 specimens were collected from 21 HIV positive and 22 control human subjects during colonoscopy. The composition of the lower gastrointestinal tract mucosal and luminal bacterial microbiome was characterized using 16S rDNA pyrosequencing and was correlated to clinical parameters as well as immune activation and circulating bacterial products in HIV patients on ART. The composition of the HIV microbiome was significantly different than that of controls; it was less diverse in the right colon and terminal ileum, and was characterized by loss of bacterial taxa that are typically considered commensals. In HIV samples, there was a gain of some pathogenic bacterial taxa. This is the first report characterizing the terminal ileal and colonic mucosal microbiome in HIV patients with next generation sequencing. Limitations include use of HIV-infected subjects on HAART therapy.PLoS Pathogens 02/2014; 10(2):e1003829. · 8.14 Impact Factor
Article: The Relation of Plasmacytoid Dendritic Cells (pDCs) and Regulatory T-Cells (Tregs) with HPV Persistence in HIV-Infected and HIV-Uninfected Women.[Show abstract] [Hide abstract]
ABSTRACT: Abstract Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.Viral immunology 02/2014; 27(1):20-5. · 1.78 Impact Factor
Article: Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study.[Show abstract] [Hide abstract]
ABSTRACT: Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the best female genital tract sampling technique is unclear. WE ENROLLED WOMEN FROM FOUR SITES IN AFRICA AND THE US TO COMPARE THREE GENITAL LEUKOCYTE SAMPLING METHODS: cervicovaginal lavages (CVL), endocervical cytobrushes, and ectocervical biopsies. Absolute yields of mononuclear leukocyte subpopulations were determined by flow cytometric bead-based cell counting. Of the non-invasive sampling types, two combined sequential cytobrushes yielded significantly more viable mononuclear leukocytes than a CVL (p<0.0001). In a subsequent comparison, two cytobrushes yielded as many leukocytes (∼10,000) as one biopsy, with macrophages/monocytes being more prominent in cytobrushes and T lymphocytes in biopsies. Sample yields were consistent between sites. In a subgroup analysis, we observed significant reproducibility between replicate same-day biopsies (r = 0.89, p = 0.0123). Visible red blood cells in cytobrushes increased leukocyte yields more than three-fold (p = 0.0078), but did not change their subpopulation profile, indicating that these leukocytes were still largely derived from the mucosa and not peripheral blood. We also confirmed that many CD4(+) T cells in the female genital tract express the α4β7 integrin, an HIV envelope-binding mucosal homing receptor. CVL sampling recovered the lowest number of viable mononuclear leukocytes. Two cervical cytobrushes yielded comparable total numbers of viable leukocytes to one biopsy, but cytobrushes and biopsies were biased toward macrophages and T lymphocytes, respectively. Our study also established the feasibility of obtaining consistent flow cytometric analyses of isolated genital cells from four study sites in the US and Africa. These data represent an important step towards implementing mucosal cell sampling in international clinical trials of HIV prevention.PLoS ONE 01/2014; 9(1):e85675. · 3.53 Impact Factor
Article: Systematic Review of the Use of Dried Blood Spots for Monitoring HIV Viral Load and for Early Infant Diagnosis.[Show abstract] [Hide abstract]
ABSTRACT: Dried blood spots (DBS) have been used as alternative specimens to plasma to increase access to HIV viral load (VL) monitoring and early infant diagnosis (EID) in remote settings. We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID. Thirteen peer reviewed HIV VL publications and five HIV EID papers were included. Depending on the technology and the viral load distribution in the study population, the percentage of DBS samples that are within 0.5 log of VL in plasma ranged from 52-100%. Because the input sample volume is much smaller in a blood spot, there is a risk of false negatives with DBS. Sensitivity of DBS VL was found to be 78-100% compared to plasma at VL below 1000 copies/ml, but this increased to 100% at a threshold of 5000 copies/ml. Unlike a plasma VL test which measures only cell free HIV RNA, a DBS VL also measures proviral DNA as well as cell-associated RNA, potentially leading to false positive results when using DBS. The systematic review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS. For early infant diagnosis, DBS has a sensitivity of 100% compared to fresh whole blood or plasma in all studies. Although limited data are available for EID, DBS offer a highly sensitive and specific sampling strategy to make viral load monitoring and early infant diagnosis more accessible in remote settings. A standardized approach for sampling, storing, and processing DBS samples would be essential to allow successful implementation. PROSPERO Registration #: CRD42013003621.PLoS ONE 01/2014; 9(3):e86461. · 3.53 Impact Factor
Article: Regulatory B Cells Inhibit Cytotoxic T Lymphocyte (CTL) Activity and Elimination of Infected CD4 T Cells after In Vitro Reactivation of HIV Latent Reservoirs.[Show abstract] [Hide abstract]
ABSTRACT: During HIV infection, IL-10/IL-10 receptor and programmed death-1 (PD-1)/programmed death-1-ligand (PD-L1) interactions have been implicated in the impairment of cytotoxic T lymphocyte (CTL) activity. Despite antiretroviral therapy (ART), attenuated anti-HIV CTL functions present a major hurdle towards curative measures requiring viral eradication. Therefore, deeper understanding of the mechanisms underlying impaired CTL is crucial before HIV viral eradication is viable. The generation of robust CTL activity necessitates interactions between antigen-presenting cells (APC), CD4+ and CD8+ T cells. We have shown that in vitro, IL-10hiPD-L1hi regulatory B cells (Bregs) directly attenuate HIV-specific CD8+-mediated CTL activity. Bregs also modulate APC and CD4+ T cell function; herein we characterize the Breg compartment in uninfected (HIVNEG), HIV-infected "elite controllers" (HIVEC), ART-treated (HIVART), and viremic (HIVvir), subjects, and in vitro, assess the impact of Bregs on anti-HIV CTL generation and activity after reactivation of HIV latent reservoirs using suberoylanilide hydroxamic acid (SAHA). We find that Bregs from HIVEC and HIVART subjects exhibit comparable IL-10 expression levels significantly higher than HIVNEG subjects, but significantly lower than HIVVIR subjects. Bregs from HIVEC and HIVART subjects exhibit comparable PD-L1 expression, significantly higher than in HIVVIR and HIVNEG subjects. SAHA-treated Breg-depleted PBMC from HIVEC and HIVART subjects, displayed enhanced CD4+ T-cell proliferation, significant upregulation of antigen-presentation molecules, increased frequency of CD107a+ and HIV-specific CD8+ T cells, associated with efficient elimination of infected CD4+ T cells, and reduction in integrated viral DNA. Finally, IL-10-R and PD-1 antibody blockade partially reversed Breg-mediated inhibition of CD4+ T-cell proliferation. Our data suggest that, possibly, via an IL-10 and PD-L1 synergistic mechanism; Bregs likely inhibit APC function and CD4+ T-cell proliferation, leading to anti-HIV CTL attenuation, hindering viral eradication.PLoS ONE 01/2014; 9(4):e92934. · 3.53 Impact Factor
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ABSTRACT: Viral load (VL) monitoring is the standard of care in developing country settings for detecting HIV treatment failure. Since 2010 the World Health Organization has recommended a phase-in approach to VL monitoring in resource-limited settings. We conducted a systematic review of the accuracy and precision of HIV VL technologies for treatment monitoring. A search of Medline and Embase was conducted for studies evaluating the accuracy or reproducibility of commercially available HIV VL assays. 37 studies were included for review including evaluations of the Amplicor Monitor HIV-1 v1.5 (n = 25), Cobas TaqMan v2.0 (n = 11), Abbott RealTime HIV-1 (n = 23), Versant HIV-1 RNA bDNA 3.0 (n = 15), Versant HIV-1 RNA kPCR 1.0 (n = 2), ExaVir Load v3 (n = 2), and NucliSens EasyQ v2.0 (n = 1). All currently available HIV VL assays are of sufficient sensitivity to detect plasma virus levels at a lower detection limit of 1,000 copies/mL. Bias data comparing the Abbott RealTime HIV-1, TaqMan v2.0 to the Amplicor Monitor v1.5 showed a tendency of the Abbott RealTime HIV-1 to under-estimate results while the TaqMan v2.0 overestimated VL counts. Compared to the Amplicor Monitor v1.5, 2-26% and 9-70% of results from the Versant bDNA 3.0 and Abbott RealTime HIV-1 differed by greater than 0.5log10. The average intra and inter-assay variation of the Abbott RealTime HIV-1 were 2.95% (range 2.0-5.1%) and 5.44% (range 1.17-30.00%) across the range of VL counts (2log10-7log10). This review found that all currently available HIV VL assays are of sufficient sensitivity to detect plasma VL of 1,000 copies/mL as a threshold to initiate investigations of treatment adherence or possible treatment failure. Sources of variability between VL assays include differences in technology platform, plasma input volume, and ability to detect HIV-1 subtypes. Monitoring of individual patients should be performed on the same technology platform to ensure appropriate interpretation of changes in VL. Prospero registration # CD42013003603.PLoS ONE 01/2014; 9(2):e85869. · 3.53 Impact Factor
Article: Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics.[Show abstract] [Hide abstract]
ABSTRACT: The intestinal mucosa is constantly facing a high load of antigens including bacterial antigens derived from the microbiota and food. Despite this, the immune cells present in the gastrointestinal tract do not initiate a pro-inflammatory immune response. Toll-like receptors (TLRs) are pattern recognition receptors expressed by various cells in the gastrointestinal tract, including intestinal epithelial cells (IEC) and resident immune cells in the lamina propria. Many diseases, including chronic intestinal inflammation (e.g., inflammatory bowel disease), irritable bowel syndrome (IBS), allergic gastroenteritis (e.g., eosinophilic gastroenteritis and allergic IBS), and infections are nowadays associated with a deregulated microbiota. The microbiota may directly interact with TLR. In addition, differences in intestinal TLR expression in health and disease may suggest that TLRs play an essential role in disease pathogenesis and may be novel targets for therapy. TLR signaling in the gut is involved in either maintaining intestinal homeostasis or the induction of an inflammatory response. This mini review provides an overview of the current knowledge regarding the contribution of intestinal epithelial TLR signaling in both tolerance induction or promoting intestinal inflammation, with a focus on food allergy. We will also highlight a potential role of the microbiota in regulating gut immune responses, especially through TLR activation.Frontiers in Immunology 01/2014; 5:60.
Article: Older Age Is Associated with Peripheral Blood Expansion of Naïve B Cells in HIV-Infected Subjects on Antiretroviral Therapy.[Show abstract] [Hide abstract]
ABSTRACT: Older HIV infected subjects were previously found to have significant B cell expansion during initial antiretroviral therapy in a prospective age-differentiated cohort of older and younger (≥45 vs. ≤30 years) HIV-infected subjects initiating antiretroviral therapy (ART) through the AIDS Clinical Trials Group. Here to further describe this expansion, using a subset of subjects from the same cohort, we characterized B cell phenotypes at baseline and after 192 weeks of ART in both older and younger HIV-infected groups and compared them to uninfected age-matched controls. We also examined whether phenotypes at baseline associated with response to tetanus and hepatitis A vaccine at 12 weeks. Forty six subjects were analyzed in the HIV infected group (21 older, 25 younger) and 30 in the control group (15 per age group). We observed naïve B cells to normalize in younger subjects after 192 weeks of ART, while in older subjects naïve B cells increased to greater levels than those of controls (p = 0.045). Absolute resting memory (RM) cell count was significantly lower in the older HIV infected group at baseline compared to controls and numbers normalized after 192 weeks of ART (p<0.001). Baseline RM cell count positively correlated with week 12 increase in antibody to tetanus vaccine among both younger and older HIV-infected subjects combined (p = 0.01), but not in controls. The age-associated naïve B cell expansion is a novel finding and we discuss several possible explanations for this observation. Relationship between RM cells at baseline and tetanus responses may lead to insights about the effects of HIV infection on B cell memory function and vaccine responses.PLoS ONE 01/2014; 9(9):e107064. · 3.53 Impact Factor
Article: Comparison of Lower Genital Tract Microbiota in HIV-Infected and Uninfected Women from Rwanda and the US.[Show abstract] [Hide abstract]
ABSTRACT: Previous studies have shown that alterations of the bacterial microbiota in the lower female genital tract influence susceptibility to HIV infection and shedding. We assessed geographic differences in types of genital microbiota between HIV-infected and uninfected women from Rwanda and the United States. Genera of lower genital tract bacterial microbiota were identified by high-throughput pyrosequencing of the 16S rRNA gene from 46 US women (36 HIV-infected, 10 HIV-uninfected) and 40 Rwandan women (18 HIV-infected, 22 HIV-uninfected) with similar proportions of low (0-3) Nugent scores. Species of Lactobacillus were identified by assembling sequences along with reference sequences into phylogenetic trees. Prevalence of genera and Lactobacillus species were compared using Fisher's exact tests. Overall the seven most prevalent genera were Lactobacillus (74%), Prevotella (56%), Gardnerella (55%), Atopobium (42%), Sneathia (37%), Megasphaera (30%), and Parvimonas (26%), observed at similar prevalences comparing Rwandan to US women, except for Megasphaera (20% vs. 39%, p = 0.06). Additionally, Rwandan women had higher frequencies of Mycoplasma (23% vs. 7%, p = 0.06) and Eggerthella (13% vs. 0%, p = 0.02), and lower frequencies of Lachnobacterium (8% vs. 35%, p<0.01) and Allisonella (5% vs. 30%, p<0.01), compared with US women. The prevalence of Mycoplasma was highest (p<0.05) in HIV-infected Rwandan women (39%), compared to HIV-infected US women (6%), HIV-uninfected Rwandan (9%) and US (10%) women. The most prevalent lactobacillus species in both Rwandan and US women was L. iners (58% vs. 76%, p = 0.11), followed by L. crispatus (28% vs. 30%, p = 0.82), L. jensenii (20% vs. 24%, p = 0.80), L. gasseri (20% vs. 11%, p = 0.37) and L. vaginalis (20% vs. 7%, p = 0.10). We found similar prevalence of most major bacterial genera and Lactobacillus species in Rwandan and US women. Further work will be needed to establish whether observed differences differentially impact lower genital tract health or susceptibility to genital infections.PLoS ONE 01/2014; 9(5):e96844. · 3.53 Impact Factor
Article: Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH.[Show abstract] [Hide abstract]
ABSTRACT: Lactobacillus dominates the lower genital tract microbiota of many women, producing a low vaginal pH, and is important for healthy pregnancy outcomes and protection against several sexually transmitted pathogens. Yet, factors that promote Lactobacillus remain poorly understood. We hypothesized that the amount of free glycogen in the lumen of the lower genital tract is an important determinant of Lactobacillus colonization and a low vaginal pH.PLoS ONE 01/2014; 9(7):e102467. · 3.53 Impact Factor
Article: In vitro evaluation of intestinal epithelial TLR activation in preventing food allergic responses[Show abstract] [Hide abstract]
ABSTRACT: Alterations in the gut microbiota composition are associated with food allergy. Toll-like receptors (TLR) respond to microbial stimuli. We studied the effects of ligation of TLR on intestinal epithelial cells (IEC) in preventing an allergic effector response. IEC monolayers (T84 cells) were co-cultured with CD3/28-activated PBMC from healthy controls or atopic patients and simultaneously apically exposed to TLR2, TLR4 or TLR9 ligands. The barrier integrity of T84 cell monolayers was significantly reduced upon co-culture with PBMC of food allergic subjects compared to healthy subjects. Apical exposure of IEC to TLR9, ligand prevented PBMC-induced epithelial barrier disruption. Using PBMC from food allergic subjects, apical TLR9 activation on IEC increased the IFN-γ/IL-13 and IL-10/IL-13 ratio, while suppressing pro-inflammatory IL-6, IL-8 and TNF-α production in an IEC-dependent manner. Hence, activation of apical TLR9 on IEC, potentially by microbiota-derived signals, may play an important role in the prevention of allergic inflammation.Clinical Immunology. 01/2014;
Article: Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.[Show abstract] [Hide abstract]
ABSTRACT: Glucose metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and metabolism in primary CD4+ and CD8+ T cells. Thirty-eight HIV-infected treatment-naïve, 35 HIV+/combination antiretroviral therapy, 7 HIV+ long-term nonprogressors and 25 HIV-control individuals were studied. Basal markers of glycolysis [e.g. glucose transporter-1 (Glut1) expression, glucose uptake, intracellular glucose-6-phosphate, and L-lactate] were measured in T cells. The cellular markers of immune activation, CD38 and HLA-DR, were measured by flow cytometry. The surface expression of the Glut1 is up-regulated in CD4+ T cells in HIV-infected patients compared with uninfected controls. The percentage of circulating CD4+Glut1+ T cells was significantly increased in HIV-infected patients and was not restored to normal levels following combination antiretroviral therapy. Basal markers of glycolysis were significantly higher in CD4+Glut1+ T cells compared to CD4+Glut1- T cells. The proportion of CD4+Glut1+ T cells correlated positively with the expression of the cellular activation marker, HLA-DR, on total CD4+ T cells, but inversely with the absolute CD4+ T-cell count irrespective of HIV treatment status. Our data suggest that Glut1 is a potentially novel and functional marker of CD4+ T-cell activation during HIV infection. In addition, Glut1 expression on CD4+ T cells may be exploited as a prognostic marker for CD4+ T-cell loss during HIV disease progression.AIDS (London, England) 12/2013; · 4.91 Impact Factor
Article: HIV RNA levels in plasma and cervical-vaginal lavage fluid in elite controllers and HAART recipients.[Show abstract] [Hide abstract]
ABSTRACT: The introduction of HAART leads to control of HIV replication to less than 50 copies/ml, similar to levels in 'elite controllers'. Low-level viral replication may be one of the contributing factors to persistent immune activation/inflammation in HAART-treated individuals. There are still gaps in our knowledge of whether low-level replication persists in systemic versus mucosal sites. Participants for this study were recruited from the Women's Interagency HIV Study. We evaluated 33 'elite controllers' who naturally controlled HIV replication and 33 matched HAART-suppressed recipients. This study employed a sensitive target-capture transcription-mediated-amplification assay to compare low-level virus concentrations in plasma and cervical-vaginal lavage (CVL) samples from HIV-positive HAART recipients and 'elite controllers'. The median (interquartile range) plasma viral load signal/cut-off (S/Co) for 'elite controllers' was 10.5 (3.9-21.1), which was significantly (P <0.001) higher than the S/Co for HAART recipients [2.0 (1-4.9)]. The majority of CVL samples from both groups had undetectable HIV RNA and the proportion of CVL samples with a cut-off more than 1.0 was not different between 'elite controllers' and HAART-suppressed recipients. This study demonstrated persistent low-level HIV replication in 'elite controllers', suggesting potential value of HAART treatment for these individuals. Absent or very low levels of HIV RNA in CVL indicate very low risk of secondary sexual transmission for both groups.AIDS (London, England) 12/2013; · 4.91 Impact Factor
Top Journals
Rush University Medical Center
Chicago, Illinois, United States
- • Department of Immunology and Microbiology
- • Department of Pediatrics
- • Department of Internal Medicine
NCI-FrederickMaryland, United States
Utrecht UniversityUtrecht, Utrecht, Netherlands
Burnet Institute
Melbourne, Victoria, Australia
- Centre for Virology
University College London
London, ENG, United Kingdom
- Department of Infection and Population Health
University of Iowa
Iowa City, IA, United States
- Department of Internal Medicine
University of Western Australia
Perth, Western Australia, Australia
- School of Pathology and Laboratory Medicine
University of California, Los AngelesLos Angeles, California, United States
National Institute of Allergy and Infectious Diseases
Maryland, United States
- Laboratory of Immunoregulation
University of California, San Francisco
San Francisco, California, United States
- Division of Hospital Medicine
University of MelbourneMelbourne, Victoria, Australia
Albert Einstein College of Medicine
New York City, NY, United States
- Department of Epidemiology & Population Health
Case Western Reserve University School of Medicine
Cleveland, OH, United States
- Department of Pathology
University of Washington SeattleSeattle, Washington, United States
Harvard Medical SchoolBoston, Massachusetts, United States
Virginia Commonwealth UniversityRichmond, Virginia, United States
University of California, Davis
Davis, California, United States
- Division of Infectious and Immunologic Diseases
University of Southern California
Los Angeles, CA, United States
- • Department of Psychiatry and Behavioral Sciences
- • Keck School of Medicine
- • Department of Pediatrics
Case Western Reserve University
Cleveland, OH, United States
- • Division of Hospital Medicine (MetroHealth Medical Center)
- • Division of Infectious Diseases and HIV Medicine
- • Center for AIDS Research
- • MetroHealth Medical Center
Rush Medical CollegeChicago, Illinois, United States
National Cancer Institute (USA)
Maryland, United States
- Experimental Immunology Branch
University of Illinois at Chicago
Chicago, Illinois, United States
- Department of Pediatrics (Chicago)
University of Antioquia
Santa Fe de Antioquia, Antioquia, Colombia
- Facultad de Medicina
Vanderbilt University
Nashville, MI, United States
- Center for Human Genetics Research (CHGR)
Rosalind Franklin University of Medicine and Science
North Chicago, IL, United States
- Microbiology and Immunology
Beth Israel Medical CenterNew York City, New York, United States
University of Maryland, Baltimore
Baltimore, MD, United States
- Institute of Human Virology
Dana-Farber Cancer InstituteBoston, Massachusetts, United States
University of Chicago
Chicago, IL, United States
- Department of Microbiology
National Institutes of Health
Bethesda, MD, United States
- Branch of Experimental Immunology
University of Wisconsin, Madison
Madison, MS, United States
- Department of Human Oncology
University of North Carolina at Chapel HillNorth Carolina, United States
Beth Israel Deaconess Medical Center
Boston, MA, United States
- Division of Viral Pathogenesis
University of MilanMilano, Lombardy, Italy
St. Vincent's Hospital SydneySydney, New South Wales, Australia
St. Luke's Medical Center (Phoenix)Phoenix, Arizona, United States


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VIDEO: Sneak Peek - Comedy Central's TOSH.O, BRICKLEBERRY and MASH UP
Tonight on Comedy Central's TOSH.O at 10:00 p.m. ET/PT, Tosh wrestles with his sexuality, reviews your brotography, and an armless girl gets a web redemption. On "BRICKLEBERRY", following "Tosh.0," Woody charges the team with the task of coming up with the cutest animal in the world in an effort to compete with Yellowstone. This week's all-new episode of MASH UP, hosted by T.J. Miller, features comedians Chris Hardwick and Deon Cole and a musical "Word Mash Up" of the LL Cool J film "S.W.A.T." with auto-tune technology, which becomes "S.W.A.T-o-Tune." Check out the clips for all three shows below!
Also on Comedy Central, "THE DAILY SHOW WITH Jon Stewart" welcomes Eugene Jarecki (Documentary Filmmaker promoting "The House I Live In") tonight at 11:00 p.m. ET/PT.
"THE COLBERT REPORT" welcomes Mayor Cory Booker (Mayor of Newark, NJ promoting the Dodge Poetry Festival) tonight at 11:30 p.m. ET/PT.
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Legal Secretary
Job Description Kelly Services is looking for an experienced Legal Secretary in Minden, NV!RESPONSIBILITIES INCLUDE:Responsible for all phases of initial intake and processing of confidential employment law claims, supporting Employment Law Group Senior Paralegals, including ...
Oct 28 -
Minden - Everything else
Executive Clinic Director
An Executive Clinic Director position is open for immediate consideration at Pit River Health Service, outside Redding, CA.
The purpose of the work is to administer and direct the program to fulfill the Pit River Health Service, Inc. primary mission of delivering the ...
Oct 28 -
Reno - Medical & healthcare
Patient Financial Services Representative - 135692
--- About Banner Lassen Medical CenterLocated in Susanville in northeast California, Banner Lassen Medical Center offers comprehensive care in a state-of-the-art facility to aid in the prevention, diagnosis, and treatment of illnesses. Our 25-bed medical center has a ...
Oct 27 -
Susanville - Everything else
Title Assistant
Job Description
Performs clerical tasks to support timely escrow closings and title recordings. Conducts title research to compile chain of title. Creates title files and prepares endorsements and supplemental documents. Investigates and interprets tax records in order to ...
Oct 27 -
Reno - Real estate
Chief Executive Officer (CEO), U.S. (Manufacturing & Production)
Chief Executive Officer (CEO), United States (Manufacturing & Production)
Location: Reno, Nevada.
Start Date: January 3rd, 2015.
Salary: $150K-$175K, plus bonus and incentives to be discussed.
Relocation: Yes, relocation assistance will be provided.
Oct 26 -
Sparks - Business & management
Oct 26 -
Reno - Business & management
HR Director
Compensation: 90-125K,
Lead and promote HR initiatives and programs that align with corporate goals and values.
Coordinate HR activities to ensure that all aspects are within legal compliance.
Cultivate, implement and administer company-wide policies and procedures.
Oct 25 -
Reno - Human resources
Credit Repair Consultant EARN $4000 per month $$$
CREDIT REPAIR GUARANTEED WITH 720 Credit Score when Completed!!!
We repair our clients credit with a $295 non-refundable deposit, which takes 30-90 days to complete. Our clients will have a credit score of 720+ guaranteed, plus we will fund anywhere between $10,000-$35,000 ...
Oct 25 -
Carson City - Marketing & PR
Oct 25 -
Reno - Marketing & PR
Oct 25 -
Sparks - Marketing & PR
Human Resources & General Affairs Manager in Reno, NV
*Position: Human Resources & General Affairs Manager*
*Location: Reno, NV*
*Hiring Style: Full time*
*Salary: DOE*
*Job purpose:*
Manages human resources and general affairs function to support the key business needs
*Establishes ...
Oct 24 -
Reno - Human resources
Title Examiner
Title Examiner:
Title Examiner provides comprehensive title insurance coverage and professional services for purchases, construction, refinances, or equity loans. The company's thorough searches, title clearance, and insurance help to produce clear property titles and ...
Oct 24 -
Reno - Real estate
Director of Finance
Compensation: 150K to 175K
• Develop and support /train the finance team
• Manage the external statutory audit process in connection with the Controllers
• Develop and maintain strong Internal Controls and corporate governance, including monthly account ...
Oct 24 -
Reno - Accounting & finance
Court Clerk Trainee or Court Clerk
CLERICALChurchill County hiring a FT Court Clerk Trainee or Court Clerk for Justice Court. Must have at least 3 yrs FT responsible clerical exp. Legal exp desirable. $16.01 - $17.67 /hour Apply by 3:00 on 11/3/14. Contact: County Personnel, 155 N. Taylor, #155, Fallon. www ...
Oct 21 -
Fallon - Everything else
Event Specialist
Summary Are you self-motivated, outgoing and friendly? Advantage Sales and Marketing wants people like you to be an Event Specialists in one of our clients' retail locations. What does an Event Specialist do? They generate excitement, brand awareness and boost sales by ...
Sep 25 -
Gardnerville - Everything else
Design and Application Engineer
The Application and Design Engineer's main responsibilities are designing low pressure injection molds for a variety of applications as presented by the customer; providing design support for new machine development; generating dimensioned drawings; and ...
Sep 25 -
Reno - Construction & trades
Ultrasound Technologist - 134266
--- About Banner Churchill Community HospitalLocated in Fallon, Nev., Banner Churchill Community Hospital is a 40-bed licensed hospital offering the most comprehensive array of medical services in rural northern Nevada. We provide comprehensive and emergency care, ...
Sep 23 -
Fallon - Everything else
Pharmacist Positions in this city, and throughout California!
Must have twelve months experience within the last three years and be licensed in California.
Under the direction of the Pharmacist-in-Charge and/or the Institution's Chief Executive Officer, Chief Medical ...
Sep 22 -
Susanville - Medical & healthcare
Certified Pharmacy Tech
Seeking Pharmacy Technicians for upcoming openings. Must have twelve months experience within the last three years and be licensed in California.
a. Under the direction of the Pharmacist-in-Charge, Pharmacist, or designee. ...
Sep 18 -
Susanville - Medical & healthcare
Retail Store Manager
~~Direct Tools Factory Outlet, a highly acclaimed World-Class superior supplier of home improvement products has an immediate need for a Retail Store Manager $38k-$42K
Job Duties Include:
• Completes store operational requirements by scheduling and assigning employees; ...
Sep 17 -
Reno - Retail & wholesale
Sep 16 -
Susanville - Medical & healthcare
Vice President Global Regulatory Affairs
About the Job
Our Client, a leading provider of ratings, research, and risk analysis, seeks a Vice President Global Regulatory Affairs for their Latin American market. He/she will report into the Regulatory and Strategy Unit.
The candidate will take responsibility for ...
Sep 5 -
Reno - Business & management
Vice President of Underwriting & Finance
Reporting to the Chief Financial Officer, the Vice President of Underwriting & Finance will be responsible for ensuring the credit worthiness of each tax credit investment. The VP will work closely with the Acquisitions, Investor Relations, Asset Management and Development ...
Sep 2 -
Reno - Business & management
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text:
Monday, 28 Jun 2010 09:01 AM
A Colorado man on a mission to hunt down Osama bin Laden says he wanted to capture him alive and bring him to justice.
Gary Faulkner said Monday on CBS' "Early Show" that he got help and inspiration from Americans, Pakistanis and others worldwide. He alluded to being helped in his search by the Pakistani government.
The out-of-work construction worker from Greeley was detained June 13 in the woods of northern Pakistan after being found with a pistol, a sword and night-vision equipment. Faulkner told officials he was out to kill the al-Qaida leader.
But on Monday, the 50-year-old Faulkner said he wanted to return to the United States with bin Laden in tow and alive.
Faulkner has said the Pakistanis treated him well and administered dialysis to treat his kidney disease.
© Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Friday, 04 Jan 2013 13:06 PM
Tens of thousands of Fatah supporters rallied in the Hamas stronghold of Gaza on Friday for the first time since they we . . .
Tuesday, 17 Jul 2012 18:11 PM
. . .
Friday, 13 Jul 2012 12:27 PM
This must be a horror flick! Please let me out of the theater!...
There are 20 million out of work. These people for the most part are illiterate...
If he is so angry, then why did he appoint the exact opposite of what we need...
We have the worst leadership.....This administration just shoves women and black...
If he did, we can only hope. This narcissistic, pathological liar couldn't tell...
Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.


text:
SoFi (Social Finance Inc.)
|Student loans
|May 2011
|San Francisco, California
|Key people
|Mike Cagney (CEO)
Nino Fanlo (CFO)
|Student loans
Social Finance, Inc. (commonly known as SoFi) is an online, peer-to-peer loan platform that connects students and recent graduates with alumni and institutional investors via school specific student loan funds. The company is a non-bank lender focused on refinancing student loans at lower rates than traditional repayment options.
SoFi was founded in 2011 by Mike Cagney, Dan Macklin, James Finnigan, and Ian Brady, four students who met at the Stanford Graduate School of Business. By leveraging the interest fellow alumni have in seeing graduates of their alma mater be successful, the founders hoped SoFi could provide more affordable options for those taking on debt to fund their education.[1] The company's inaugural loan program was a $2 million pilot at the founders' alma mater – the Stanford Graduate School of Business. For this pilot, 40 alumni invested an average of $50,000 to 100 students.[2][3][4]
In September 2012, SoFi raised $77.2 million, led by Baseline Ventures, with participation from DCM and Renren.[5][6]
On October 2, 2013, SoFi announced that it had raised $500 million in debt and equity to fund and refinance student loans. This total funding amount came from $90 million in equity, $151 million in debt, and $200 million in bank participations, with the remaining capital from alumni and community investors.[7] The $151 million in debt includes a $60 million line of credit from Morgan Stanley, and a $41 line of credit from Bancorp.[8][9][10]
As of September 2013, SoFi had funded $200 million in loans to 2500 borrowers at the company's 100 eligible schools.[11]
In November 2013, SoFi announced a deal with Barclays and Morgan Stanley to create a bond backed by peer-to-peer student loans, and this would create the first securitization of these loans to receive a credit rating.[12]
In April 2014, SoFi raised $80 million in a Series C round led by Discovery Capital Management with participation from Peter Thiel, Wicklow Capital, and existing investors. Money was raised to expand the footprint of the company's student loan refinancing business and to extend into new products like mortgages and personal loans.[13]
SoFi utilizes an alumni-funded lending model that connects students and recent graduates with alumni and institutional investors via school specific student loan funds.[14] Investors receive a financial return and borrowers receive rates lower than the federal government. The company seeks to minimize defaults by focusing on low-risk students and graduates.[15]
According to SoFi, graduates refinancing with the company can save up to $26,700 if switching from a 10-year loan with a weighted average rate of 7.67% to SoFi's best 10-year rate of 5.49%.[16] In addition to financial benefits, borrowers gain access to career development experts, support and mentorship when starting a company, and a community of individuals invested in their success.[17][18]
- ^ "SoFi Tapping Alumni to Help With Student Loans". The New York Times. 3 April 2012.
- ^ "SoFi Tapping Alumni to Help With Student Loans". The New York Times. 3 April 2012.
- ^ "SoFi's New Take on $1 Trillion Student Loan Market". Forbes. 2 April 2012.
- ^ "Student Loans: For a Great Deal, Borrow from Alumni". Time. 2 April 2012.
- ^ "Social Finance Lands $77M From Baseline, Renren To Help Solve The Student Debt Crisis". TechCrunch. 11 September 2012.
- ^ "Student-Loan Online Start-Up Gets Financing". The Wall Street Journal. 11 September 2012.
- ^ "SoFi raises $500M to fix the broken student loan market". VentureBeat. 2 October 2013.
- ^ "SoFi Gets $60M in Loan Funding from Morgan Stanley". American Banker. 26 March 2013.
- ^ "MBA Lender seeks to securitize student debt". The Financial Times. 26 March 2013.
- ^ "SoFi gets an additional $41M to keep students from falling into debt". 4 June 2013.
- ^ [(http://www.lendacademy.com/sofi-adding-leverage-for-their-alumni-investors/ "SoFi Adding Leverage For Their Alumni Investors"]. Lend Academy. 24 September 2013.
- ^ "Barclays Helps Startup Structure First Rated P2P Bond". Bloomberg. 14 November 2013.
- ^ "SoFi $80m fundraising paves way for growth beyond student loans". The Financial Times. 3 April 2014.
- ^ "A new way to crowdsource your student loans". MSN Money. 26 July 2013.
- ^ "Harvard Graduates Targeted by Alumni-Backed Loan Funds". Bloomberg. 11 December 2012.
- ^ "Double Take: When to Consider Refinancing Your Student Loans". SoFi. 22 October 2013.
- ^ "A new way to crowdsource your student loans". MSN Money. 26 July 2013.
- ^ [(http://www.lendacademy.com/sofi-adding-leverage-for-their-alumni-investors/ "SoFi Adding Leverage For Their Alumni Investors"]. Lend Academy. 24 September 2013.


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Chet Faker - Best New Songs, Albums, & Features
Listen to the best new songs and albums from Chet Faker as well as features written by the DJ Booth Staff. Last updated on September 26, 2014
Artist: Chet Faker
Song: Lover
When I think of genres that go well together, EDM and classic rock isn't the first pairing that comes to mind. But hey, mixing chocolate and peanut butter was also unheard of once upon a time. With joint single Lover,... More
Posted about 4 weeks ago
Artist: Chet Faker
Featuring: GoldLink
Song: On You
A buzzmaking producer and electronic musician who calls Melbourne, Australia home, Chet Faker makes his first foray into The DJBooth with new promo cut On You. Released as part of Adidas's #SongsFromScratch series,... More
Posted 3 months ago
- Shady XV: Eminem is Dropping a New Album & I Don't Care
- S1 Confirms Kanye West Working on New Album, Songs Are "Feel Good" #A3CProAudio
- 5 Fresh Songs You Might Have Missed (10/20)
- PRhyme (Royce Da 5'9" & DJ Premier) - U Looz
- Lil Dicky ft. Michael Christmas & Rockie Fresh - Would You Believe That
- DeJ Loaf - Sell Sole
- Heat Check: How Do You Feel About Drake's "How About Now"
- 10 Must Have Hip-Hop Downloads of the Week (10/17)
- All 72 of Drakes Billboard Top 100 Songs
- DJBooth Announces Our New Top Prospects…
- The Best Hip-Hop & R&B Songs of 2014 (Ongoing)
DJBooth TV
Discover the best new songs, videos, and albums added to the Booth.


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Short Cuts
Benedictine bishop and abbot. He governed the abbey of St. Peter at Besalu, in Catalonia, Spain.
On April 16, 1879, Bernadette -- or Sister Marie-Bernard, as she was known within her order -- died in the Sainte Croix (Holy Cross) Infirmary of the Convent of Saint-Gildard. She was ... continue reading | shop
Simon Peter or Cephas, the first pope, Prince of the Apostles, and founder, with St. Paul, of the see of Rome. Peter was a native of Bethsaida, near Lake Tiberias, the son of John, and ... continue reading | shop
The name Gabriel means "man of God," or "God has shown himself mighty." It appears first in the prophesies of Daniel in the Old Testament. The angel announced to Daniel the prophecy of the ... continue reading | shop
On December 16, there is named in the Roman Martyrology and in certain Irish calendars a Saint Bean in Ireland, who had been confused with the St. Bean whose feast is still observed in the Scottish ... continue readingMore Saint of the Day
The woman of Jerusalem who wiped the face of Christ with a veil while he was on the way to Calvary. According to tradition, the cloth was imprinted with the image of Christ's face." Unfortunately, there is no historical evidence or scriptural reference to this ... continue readingMore Female Saints
St. Michael the Archangel - Feast day - September 29th The name Michael signifies "Who is like to God?" and was the warcry of the good angels in the battle fought in heaven against satan and his followers. Holy Scripture describes St. Michael as "one of the chief ... continue reading
The name Gabriel means "man of God," or "God has shown himself mighty." It appears first in the prophesies of Daniel in the Old Testament. The angel announced to Daniel the prophecy of the seventy weeks. His name also occurs in the apocryphal book of Henoch. He was the ... continue reading
St. John Vianney, Priest (Patron of priests) Feast day - August 4 Universally known as the "Cure of Ars)," St. John Mary Vianney was ordained a priest in 1815. Three years later he was made ... continue reading
Saint Birgitta was the daughter of Uppland�s Lagman, Birger Petersson and his wife, Ingeborg, who was a member of the same clan as the reigning family. Birgitta�s family was pious; her father went to ... continue reading
By Deacon F.K. Bartels
St. Teresa's whole life is one of simple beauty and fervent purpose; it is a life contained in Christ. She shows us how to live the same way through Prayer.On reading from St. Teresa, a deep feeling of her love for His Majesty envelops us; we begin, in a very real, ... continue readingMore Christian Saints & Heroes


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Posted Feb 05, 2013By
SCHLADMING, Austria (AP) – Lindsey Vonn crashed during the super-G and has been taken by helicopter to a hospital from the world championships after apparently injuring her right knee.
The American lost balance on her right leg while landing after a jump. Her ski came off immediately, and Vonn slid off course and hit a gate before coming to a standstill.
Vonn received medical treatment on the slope for 12 minutes before going to the hospital.
She trailed race leader Tina Maze of Slovenia by 0.12 seconds shortly before the crash.
The race, which was postponed for 3 1/2 hours because of fog, restarted after a 15-minute delay.
Stillwater advances after it pounds Roseville, 53-20, in the sectional playoffs Friday night in Stillwater, October
After a brief hiatus, Bob and Kevin are back and discussing the Vikings, their favorite topic, and making predictio
Our daily countdown of the top newsmakers, groundbreakers and world-class fakers by Kevin Cusick
Goalie Darcy Kuemper stopped 26 shots for this third shutout in four starts as the Minnesota Wild beat the Arizona
Every week, Kevin Cusick makes his picks against the Las Vegas point spread, the way God intended …
Shabazz Muhammad scored 19 points and Nikola Pekovic had 15 points and 13 rebounds as the Minnesota Timberwolves cr


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"If you build it, they will come" seems to be Lumberton's motto as of late. In addition to new commercial and residential construction, there are a few notable multi-million dollar projects popping up in the city.
The L.L. Melton Family Life Center, formerly the L.L. Melton YMCA, is one step closer to a complete retrofit that would keep the center open after City Council members approved a lease agreement with benefactor Dr. Donna Farrell on Tuesday, July 9.
Lamar University has named Juan Zabala executive director of the Lamar University Foundation, officials announced.
UPDATE: Funeral service will be at 2 p.m. Friday, July 19, at Wesley United Methodist Church on Major Drive in Beaumont, and internment at Forest Lawn Cemetery, with a reception to follow at the Beaumont Country Club on Pine Street in Beaumont.
An illegal Guatemalan immigrant is in custody on charges of murder in the slaying of a Beaumont man.
Texas A&M to auction exclusive license plate
Jefferson County Sheriff's Office Deputy Larry Gilder was given the 2013 East Texas Peace Officer Association's (ETPOA) "Outstanding Peace Officer of the Year Award" at the 62nd Annual ETPOA Training Convention Awards Banquet on Tuesday, June 25, at the John D.
Southeast Texas has a new Eagle Scout and he's paving the way for future generations to enjoy one of the area's most pristine parks.
Beaumont/Port Arthur
While we harbor no disrespect for the Wall Street Journal who called us "that scrappy little paper from Southeast Texas," we prefer to think of ourselves as simple seekers of the truth. We're of the opinion that headlines and sound bites never tell the whole story. Our readers demand all the facts, facets and flavors of every story or event. And, they expect to be informed, educated and stirred to action.
For this week's New York Times crossword puzzle, pick up a copy of this week's The Examiner on newsstands now.


text:
LOS ANGELES (AP) - Los Angeles Police Chief Charlie Beck said he plans to step up patrols of elementary and middle schools in the nation's second-largest school district by assigning officers to visit them at least once a day.
OFFICIALS ID CHP OFFICER KILLED IN OFF-DUTY CRASH: FAIRFIELD (AP) - Officials have released the name of a veteran California Highway Patrol officer who was killed in an off-duty motorcycle crash, while his colleagues remembered him as a dedicated public servant.
LOS ANGELES (AP) - A Southern California man has been arrested on suspicion of stabbing his grandmother to death, possibly with a barbecue fork.
NAPA (AP) - Napa Valley, one of the world's premier wine growing regions, has an uncommon problem these days: not enough new grapevine root stock is available to supply the massive replanting that's under way there.
OAKLAND (AP) - Hundreds of guns have been taken off the streets of Oakland and San Francisco in a gun buyback program that Oakland police Officer Johnna Watson described as a "huge success."
ENCINITAS (AP) - Public school yoga instructor Katie Campbell proudly looks out at 23 first graders as they contain their squirming in a kid-friendly version of the lotus position.
SAN FRANCISCO (AP) - Pacific Gas and Electric Co. said it has fired or suspended nearly 20 workers after discovering legally required inspections may not have been performed.
SACRAMENTO (AP) - Impoverished Californians will soon get free cellphones.
SACRAMENTO (AP) - While cigarette sales have plunged, sales of smokeless tobacco products have surged in the past decade in California, with use among high school students especially leaving state public health officials concerned, according to a state report.
JURY: LAPD MUST PAY $24M FOR SHOOTING OF BOY, 13: LOS ANGELES (AP) - A jury has ruled the Los Angeles Police Department must pay $24 million for a 13-year-old boy shot by an officer and paralyzed as he played with a replica gun.
WOMAN'S SEX ROMP EXPOSES WORKERS' COMP FRAUD : SAN MATEO (AP) - A sex romp at a public park helped prosecutors convict a California woman of faking an ankle injury to collect workers' compensation payments, authorities said.
SACRAMENTO (AP) - California's population grew at the same modest pace during the year that ended in July as it did during the previous 12 months, sending the population to 37.8 million, according to a state population estimate released Thursday.
STOCKTON (AP) - Stockton police are releasing more details about a suspected carjacker facing murder charges following a high-speed chase that ended when the stolen car crashed and killed his female accomplice.
SACRAMENTO, Calif. (AP) - A federal appeals court on Thursday affirmed California's right to cut payments made to Medi-Cal providers by 10 percent, a victory that Gov. Jerry Brown's administration says will save the state more than $330 million a year.
HUNTINGTON BEACH (AP) - Seawater spread into several low-lying communities along the California coast Thursday morning as unusually high "king tides" pulled the Pacific Ocean farther ashore than normal.
SACRAMENTO (AP) - Gov. Jerry Brown on Tuesday signed the nation's first statewide ban on single-use plastic bags at grocery and convenience stores, driven to action by pollution in streets and waterways.
OAKLAND (AP) - The University of California will examine whether it admits too many out-of-state and international students as it develops a budget for the next academic year that might include the system's first tuition increases in four years, university President Janet Napolitano said Tuesday.
BELL GARDENS (AP) - The mayor of a Los Angeles suburb was shot to death Tuesday during an argument with his wife, who was taken into custody, authorities said.
RIVERSIDE (AP) - A Southern California woman arrested with a trash bin containing her ex-boyfriend's body parts has been sentenced to 26 years to life in prison.
SAN FRANCISCO (AP) - Responding to concerns raised by gay and transgender students and employees, University of California President Janet Napolitano directed the system's 10 campuses on Monday to create more gender-neutral restrooms and to allow students to update their records with a preferred name that does not necessarily match their legal name.
SACRAMENTO (AP) - California has exhausted its initial firefighting budget just three months into its fiscal year, Gov. Jerry Brown's administration said Monday, requiring the drought-plagued state to shift $70 million from a reserve fund as it enters what is traditionally the worst of its fire season.
SACRAMENTO (AP) - Gov. Jerry Brown announced Monday that he had signed a bill allowing local governments a partial replacement tool for financing infrastructure projects such as water systems, transit facilities and affordable housing.
SAN FRANCISCO (AP) - Efforts to relocate protected birds so the old eastern span of the San Francisco-Oakland Bay Bridge can be torn down could cost the state more than $30 million, a newspaper said Monday.
SACRAMENTO (AP) - Gov. Jerry Brown announced Monday that he signed a package of bills to help foster children in California by encouraging early placement with relatives and extending support to finish college.
FRESNO (AP) - Federal prosecutors say a 22-year-old Fresno man has been sentenced to 18 months in prison for aiming a laser pointer at a California Highway Patrol airplane.
BODY FOUND ON SHORE IN CONTRA COSTA COUNTY: MARTINEZ (AP) - Authorities are investigating the discovery of a woman's body that was found washed up on the shore at Lone Tree Point in the San Francisco Bay area.
SACRAMENTO (AP) - Gov. Jerry Brown vetoed on Saturday a group of bills aimed at promoting transparency in governance and greater disclosure in political campaigns, saying existing laws on those matters are enough.
LOS ANGELES (AP) - Banks are reaping bigger fees whenever customers overdraw their checking accounts or use ATMs that are not affiliated with their lender, a new survey shows.
SACRAMENTO (AP) - With harvest time across California, many of the state's once-robust crops - from the grapes that make world-famous wines to popular almonds - are anticipated to be smaller than usual this year due to the state's historic drought.
SACRAMENTO (AP) - Gov. Jerry Brown signed on Saturday a bill that he said will modernize California's century-old initiative process and provide better information to voters on ballot measures.


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Crisco wrote:Monaco sounds like it could be really good and I'm reet excited about State Of Decay.
JamPop wrote:Where's State of Decay? And how about some love for God Mode. Just watched an 18 minute gameplay video for it and it's looking very solid so far.
Users browsing this forum: crippyd, Gabriel Xivixsi and 7 guests


text:
Translation of Capricorn in Spanish:
- 1.1 (constellation) (no article/sin artículo) Capricornio 1.2 countable/numerable (person) Capricornio or capricornio (masculine and feminine), capricorniano, (masculine, feminine) see also Aquarius
Definition of Capricorn in:
- The British & World English dictionary
- The US English dictionary
Grammar and usage help for Spanish:
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Spain had three civil wars known as the guerras carlistas (1833-39, 1860, 1872-76). When Fernando VII died in 1833, he was succeeded not by his brother the Infante Don Carlos de Borbón, but by his daughter Isabel, under the regency of her mother María Cristina. This provoked a mainly northern-Spanish revolt, with local guerrillas pitted against the forces of the central government. The Carlist Wars were also a confrontation between conservative rural Catholic Spain, especially the Basque provinces and Aragón, led by the carlistas, and the progressive liberal urban middle classes allied with the army. Carlos died in 1855, but the carlistas, representing political and religious traditionalism, supported his descendants' claims until reconciliation in 1977 with King Juan Carlos.


text:
(Source: fashionfaves)
Drunk Mellie - 3x03 vs. 3x17
Picasso in his studio.
(Source: patrickhumphreys)
This is stunning.
Ill always be a sap and reblog this
(Source: cute-overload)
(Source: truthgraphs)
Louboutins are redefining the "nude" pump— now available in five shades. Great initiative!
If you don't understand why this is A Big Deal, you don't understand the glass ceiling in fashion even when it comes to being a non-white consumer.
(Source: n-i-c-o-t-i-n-e)


text:
Q: Ebayers and DP
Hey all,
I've noticed here and there some posting on DP about items that are sold on ebay. The part that I'm questioning is how people feel if that posting on DP is from the ebay seller themselves. I feel it's inappropriate to put your own posting on there but I don't think there is a policy against it.
Anyone have any thoughts on this?
8 Comments
Acarone posted here http://dealspl.us/answer/d/15933
"We do not allow self-promotion on dealspl.us. If you represent a retailer you can apply to have your store/website added to dealspl.us here:
dealspl.us for retailers: http://dealspl.us/info/retailers
However, even if approved, we ask that retailers only share about a deal or coupon a day from their own site or business."
nimase85 (rep: 15.8k) posted Feb 08, 2013
|If you feel like that is what someone is doing you could always go to http://dealspl.us/info/contact and report them
nimase85 (rep: 15.8k) posted Feb 08, 2013
Hmm before reporting someone I would leave a comment on their deal--maybe they just have not read everything and don't know.
As an ebay seller myself I wouldn't post here b/c I can't afford to undercut the big ebay sellers but ebay really makes you sensitive to people that report/give negative feedback without saying anything first.
dealwagger (rep: 10.2k) posted Feb 08, 2013
|Ive also noticed a few people that are promoted items from their own website
helloamy1977 (rep: 2.53k) posted Feb 09, 2013
Recent Replies
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Kohl's 30% Code (9/10 - 9/18/2014)
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- Mobile malware making Australians trust mobile devices less over time
- Google project aims to preserve privacy when collecting software stats
- Privileged-account risk multiplies for Australia's cloud-hungry businesses: CyberArk
- Petition targets Apple over 'spyware' in OS X Yosemite
- Vulnerabilities found in more command-line tools, wget and tnftp get patches
Office 2013 - News, Features, and Slideshows
Office 2013 in pictures
News about Office 2013
Microsoft Australia reveals Office 365 Home Premium pricing
Microsoft has revealed local pricing for Office 365 Home Premium, a cloud-based suite of productivity apps. The recommended retail price (RRP) of the suite is $119 for an annual subscription or $12 per month.
In Pictures: Office 2013 - 10 new useful features
See how Microsoft's popular applications are changing along with the Windows OS
In Pictures: 10 new additions in Office 2013
This is a heady time for Microsoft as it rolls out an ambitious OS and polishes off its productivity suite, billed as "the new Office."
In Pictures: 10 best Office 2013 features, according to Microsoft
We asked the team behind Microsoft Office 2013 to highlight the 10 new features in the new Office suite that stand out the most. Here they are.


text:
Added Feb 10, 2012
by sewnknitmom
Concord, United ...
I haven't made many knit tops. I do like it, and the fit. The color is nice too. I need to work on making better facings for knit tops. The gathered front adds a nice touch.
Feb 10, 2012, 06.22 AMby schnui
Lovely top.
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Editors' Pick
Dress up outerwear with deep shawl collars and sew up a lovely fitted dress with a flounced hemline.
Sew the Shawl Collar Fit and Flare Coat
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Sew yourself a bunch of different colored pullovers this season for a cozy and quick project!
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