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Paper Chase is a research database designed to offer abstracts of research articles published in journals that have a highly rated impact factor as determined by ISI Impact Factor and PageRank. Abstracts are organized by date, with the most recently published papers listed first.
Paper Chase
Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.
VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132, USA.
The mechanisms by which ethanol damages the developing and adult central nervous system (CNS) remain unclear. Activity-dependent neuroprotective protein (ADNP) is a glial protein that protects the CNS against a wide array of insults and is critical for CNS development. NAPVSIPQ (NAP), a potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential tyrosine phosphorylation of Fyn kinase and the scaffold protein Crk-associated substrate (Cas). Pharmacological inhibition of Fyn kinase or expression of a Fyn kinase siRNA abolished NAP-mediated axon outgrowth. Concentrations of ethanol attained after social drinking blocked NAP-mediated axon outgrowth (IC(50) = 17 mM) by inhibiting NAP activation of Fyn kinase and Cas. These findings identify a mechanism for ADNP regulation of glial-neuronal interactions in developing cerebellum and a pathogenesis of ethanol neurotoxicity.
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|By Marketwired .
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|January 29, 2013 11:00 AM EST
PORTLAND, OR--(Marketwire - January 29, 2013) - Integra Telecom Inc., a provider of fiber-based, business-grade networking, communications and technology solutions, has partnered with Digital Realty to provide fiber connectivity and network communications to two of Digital Realty's data centers located on the West Coast. The data centers, located in Sacramento, Calif. and Hillsboro, Ore., provide around-the-clock, business-critical IT and network infrastructure to a variety of businesses, creating new opportunities for Integra to reach enterprise and wholesale customers.
"As more enterprises turn to data center experts like Digital Realty to furnish their IT infrastructure, it opens new avenues to leveraging our broad portfolio of fiber assets throughout our network footprint," said Joe Harding, senior vice president of product & marketing at Integra Telecom. "These data centers and the customers who rely on them demand dependable, high-speed networking and Ethernet transport, and Integra's fiber and integrated services are ideally suited to their stringent requirements."
The partnership reflects Integra's investment in high-performance, extremely reliable Ethernet solutions. By extending fiber to strategically located data centers within the company's footprint, Integra is positioned to deliver a ubiquitous network solution for customers who turn to data center providers to maintain their physical IT infrastructure or remotely host their business applications. Enterprise customers such as those in healthcare, government and education markets as well as wholesale carrier customers benefit from Integra's growing list of data center partnerships.
"With its high-density, fully owned and operated fiber network and suite of flexible, integrated products, we're pleased to have a service provider such as Integra powering our data centers," said David Caron, senior vice president of Portfolio Management for Digital Realty. "Integra, like Digital Realty, is committed to providing solutions that meet the growing, data-intensive demands of today's business customer."
Digital Realty is a leading global provider of data center solutions and partners with fiber-based networking communications providers such as Integra to deliver high-capacity, cloud enabled and virtualized solutions to business customers.
About Integra Telecom
Integra is one of the largest facilities-based providers of communication and networking services in the western United States. We connect businesses of all sizes with advanced networking, communications and technology solutions in 35 metropolitan markets. Integra owns and operates an enterprise-class network consisting of a 5,000-mile long-haul fiber-optic network, 3,000 miles of metropolitan fiber and a nationwide IP/MPLS network. Our fiber network connects directly to more than 2000 enterprise buildings and data centers. Through our expansive Ethernet-over-copper footprint, we can deliver high-bandwidth services to more than 400,000 businesses. At Integra, we understand our customers need reliable, secure and flexible solutions delivered with unmatched expertise and quality of service. For more information, visit www.integratelecom.com.
Scenna Shipley
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James McIntyre
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SYS-CON Events announced today that SOA Software, an API management leader, will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. SOA Software is a leading provider of API Management and SOA Governance products that equip business to deliver APIs and SOA together to drive their company to meet its business strategy quickly and effectively. SOA Software's technology helps businesses to accelerate their digital channels with APIs, drive partner adoption, monetize their assets, and achieve a...
Oct. 31, 2014 07:15 PM EDT Reads: 2,109
SYS-CON Events announced today that Aria Systems, the recurring revenue expert, has been named "Bronze Sponsor" of SYS-CON's 15th International Cloud Expo®, which will take place on November 4-6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Aria Systems helps leading businesses connect their customers with the products and services they love. Industry leaders like Pitney Bowes, Experian, AAA NCNU, VMware, HootSuite and many others choose Aria to power their recurring revenue business and deliver exceptional experiences to their customers.
Oct. 31, 2014 06:30 PM EDT Reads: 2,177
SYS-CON Events announced today that AgilePoint, the leading provider of Microsoft-centric Business Process Management software, will exhibit at SYS-CON's 2nd International @ThingsExpo which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. AgilePoint is the leading provider of Microsoft-based Business Process Management (BPM) software products, has 1,300+ on-premise and cloud deployments in 25+ countries and provides the same advanced BPM feature set as J2EE vendors like IBM and Appian for the Microsoft .NET native environment. AgilePoint customer...
Oct. 31, 2014 05:00 PM EDT Reads: 1,265
The Internet of Things (IoT) promises to evolve the way the world does business; however, understanding how to apply it to your company can be a mystery. Most people struggle with understanding the potential business uses or tend to get caught up in the technology, resulting in solutions that fail to meet even minimum business goals. In his session at Internet of @ThingsExpo, Jesse Shiah, CEO / President / Co-Founder of AgilePoint Inc., will show what is needed to leverage the IoT to transform your business. He will discuss opportunities and challenges ahead for the IoT from a market and tec...
Oct. 31, 2014 04:00 PM EDT Reads: 1,604
SYS-CON Events announced today that Utimaco will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Utimaco is a leading manufacturer of hardware based security solutions that provide the root of trust to keep cryptographic keys safe, secure critical digital infrastructures and protect high value data assets. Only Utimaco delivers a general-purpose hardware security module (HSM) as a customizable platform to easily integrate into existing software solutions, embed business logic and build s...
Oct. 31, 2014 03:00 PM EDT Reads: 1,963
One of the biggest challenges when developing connected devices is identifying user value and delivering it through successful user experiences. In his session at Internet of @ThingsExpo, Mike Kuniavsky, Principal Scientist, Innovation Services at PARC, will describe an IoT-specific approach to user experience design that combines approaches from interaction design, industrial design and service design to create experiences that go beyond simple connected gadgets to create lasting, multi-device experiences grounded in people's real needs and desires.
Oct. 31, 2014 02:00 PM EDT Reads: 1,830
The Internet of Things will greatly expand the opportunities for data collection and new business models driven off of that data. In her session at Internet of @ThingsExpo, Esmeralda Swartz, CMO of MetraTech, will discuss how for this to be effective you not only need to have infrastructure and operational models capable of utilizing this new phenomenon, but increasingly service providers will need to convince a skeptical public to participate. Get ready to show them the money! Speaker Bio: Esmeralda Swartz, CMO of MetraTech, has spent 16 years as a marketing, product management, and busin...
Oct. 31, 2014 09:00 AM EDT Reads: 2,341
SYS-CON Events announced today that TeleStax, the main sponsor of Mobicents, will exhibit at Internet of @ThingsExpo, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. TeleStax provides Open Source Communications software and services that facilitate the shift from legacy SS7 based IN networks to IP based LTE and IMS networks hosted on private (on-premise), hybrid or public clouds. TeleStax products include Restcomm, JSLEE, SMSC Gateway, USSD Gateway, SS7 Resource Adaptors, SIP Servlets, Rich Multimedia Services, Presence Services/RCS, Diame...
Oct. 31, 2014 09:00 AM EDT Reads: 1,706
Samsung VP Jacopo Lenzi, who headed the company's recent SmartThings acquisition under the auspices of Samsung's Open Innovaction Center (OIC), answered a few questions we had about the deal. This interview was in conjunction with our interview with SmartThings CEO Alex Hawkinson. IoT Journal: SmartThings was developed in an open, standards-agnostic platform, and will now be part of Samsung's Open Innovation Center. Can you elaborate on your commitment to keep the platform open? Jacopo Lenzi: Samsung recognizes that true, accelerated innovation cannot be driven from one source, but requires a...
Oct. 31, 2014 09:00 AM EDT Reads: 3,385
Things are being built upon cloud foundations to transform organizations. This CEO Power Panel at 15th Cloud Expo, moderated by Roger Strukhoff, Cloud Expo and @ThingsExpo conference chair, will address the big issues involving these technologies and, more important, the results they will achieve. How important are public, private, and hybrid cloud to the enterprise? How does one define Big Data? And how is the IoT tying all this together?
Oct. 31, 2014 08:45 AM EDT Reads: 1,997
We certainly live in interesting technological times. And no more interesting than the current competing IoT standards for connectivity. Various standards bodies, approaches, and ecosystems are vying for mindshare and positioning for a competitive edge. It is clear that when the dust settles, we will have new protocols, evolved protocols, that will change the way we interact with devices and infrastructure. We will also have evolved web protocols, like HTTP/2, that will be changing the very core of our infrastructures. At the same time, we have old approaches made new again like micro-services...
Oct. 31, 2014 07:00 AM EDT Reads: 1,670
SYS-CON Events announces a new pavilion on the Cloud Expo floor where WebRTC converges with the Internet of Things. Pavilion will showcase WebRTC and the Internet of Things. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices--computers, smartphones, tablets, and sensors – connected to the Internet by 2020. This number will continue to grow at a rapid pace for the next several decades.
Oct. 30, 2014 05:30 PM EDT Reads: 2,218
The only place to be June 9-11 is Cloud Expo & @ThingsExpo 2015 East at the Javits Center in New York City. Join us there as delegates from all over the world come to listen to and engage with speakers & sponsors from the leading Cloud Computing, IoT & Big Data companies. Cloud Expo & @ThingsExpo are the leading events covering the booming market of Cloud Computing, IoT & Big Data for the enterprise. Speakers from all over the world will be hand-picked for their ability to explore the economic strategies that utility/cloud computing provides. Whether public, private, or in a hybrid form, clo...
Oct. 30, 2014 05:30 PM EDT Reads: 1,459
SYS-CON Events announced today that Gridstore™, the leader in software-defined storage (SDS) purpose-built for Windows Servers and Hyper-V, will exhibit at SYS-CON's 15th International Cloud Expo®, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Gridstore™ is the leader in software-defined storage purpose built for virtualization that is designed to accelerate applications in virtualized environments. Using its patented Server-Side Virtual Controller™ Technology (SVCT) to eliminate the I/O blender effect and accelerate applications Gridsto...
Oct. 30, 2014 02:00 PM EDT Reads: 2,612
SYS-CON Events announced today that Red Hat, the world's leading provider of open source solutions, will exhibit at Internet of @ThingsExpo, which will take place on November 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA. Red Hat is the world's leading provider of open source software solutions, using a community-powered approach to reliable and high-performing cloud, Linux, middleware, storage and virtualization technologies. Red Hat also offers award-winning support, training, and consulting services. As the connective hub in a global network of enterprises, partners, a...
Oct. 30, 2014 12:15 PM EDT Reads: 2,089
As the Internet of Things unfolds, mobile and wearable devices are blurring the line between physical and digital, integrating ever more closely with our interests, our routines, our daily lives. Contextual computing and smart, sensor-equipped spaces bring the potential to walk through a world that recognizes us and responds accordingly. We become continuous transmitters and receivers of data. In his session at Internet of @ThingsExpo, Andrew Bolwell, Director of Innovation for HP's Printing and Personal Systems Group, will discuss how key attributes of mobile technology – touch input, senso...
Oct. 30, 2014 12:00 PM EDT Reads: 1,777
The Internet of Things (IoT) is making everything it touches smarter – smart devices, smart cars and smart cities. And lucky us, we're just beginning to reap the benefits as we work toward a networked society. However, this technology-driven innovation is impacting more than just individuals. The IoT has an environmental impact as well, which brings us to the theme of this month's #IoTuesday Twitter chat. The ability to remove inefficiencies through connected objects is driving change throughout every sector, including waste management. BigBelly Solar, located just outside of Boston, is trans...
Oct. 30, 2014 11:00 AM EDT Reads: 2,202
Connected devices and the Internet of Things are getting significant momentum in 2014. In his session at Internet of @ThingsExpo, Jim Hunter, Chief Scientist & Technology Evangelist at Greenwave Systems, will examine three key elements that together will drive mass adoption of the IoT before the end of 2015. The first element is the recent advent of robust open source protocols (like AllJoyn and WebRTC) that facilitate M2M communication. The second is broad availability of flexible, cost-effective storage designed to handle the massive surge in back-end data in a world where timely analytics...
Oct. 30, 2014 08:00 AM EDT Reads: 1,637
Internet of @ThingsExpo Silicon Valley announced on Thursday its first 12 all-star speakers and sessions for its upcoming event, which will take place November 4-6, 2014, at the Santa Clara Convention Center in California. @ThingsExpo, the first and largest IoT event in the world, debuted at the Javits Center in New York City in June 10-12, 2014 with over 6,000 delegates attending the conference. Among the first 12 announced world class speakers, IBM will present two highly popular IoT sessions, which will take place November 4-6, 2014 at the Santa Clara Convention Center in Santa Clara, Calif...
Oct. 30, 2014 07:30 AM EDT Reads: 2,311
From a software development perspective IoT is about programming "things," about connecting them with each other or integrating them with existing applications. In his session at @ThingsExpo, Yakov Fain, co-founder of Farata Systems and SuranceBay, will show you how small IoT-enabled devices from multiple manufacturers can be integrated into the workflow of an enterprise application. This is a practical demo of building a framework and components in HTML/Java/Mobile technologies to serve as a platform that can integrate new devices as they become available on the market.
Oct. 29, 2014 02:15 PM EDT Reads: 2,085

subset: commoncrawl


text:
17 Adorable Reasons To Sign Up For The BuzzFeed Animals Newsletter
Email? More like SQUEEmail.
Email? More like SQUEEmail.
Raymond Sultan 5 months ago 137 responses
It could get sloppy. It might get awkward. It will get boring. But you can get through it.
Matt Kiebus a year ago 70 responses
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BuzzFeed is currently working with select partners to help them track what's hot on their sites using the same advanced social tracking and analytics tools used on BuzzFeed.com.
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Nekton-Bio for Bird Feathering 150g (5.29oz)
$ 38.24
DiCalcium Phosphate 1lb. Powder Pet Feed Supplement
$ 6.45
Poultry Numbered Leg Bandette White size 12 (single band)
$ 0.89
Sponge Ball Cat Toy 4 pack
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Omega One Medium Sinking Goldfish Pellets Fish Food 8-oz
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Nekton-Lori Complete Lory Diet 6000g (13.23lbs)
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15 Awesome Geek-Themed Wedding Rings
Getting hitched soon but struggling to find the perfect ring? Then perhaps you should check out these 15 awesomely geeky wedding rings, which take inspiration from video games, TV and movies.
5 Deadliest Mushrooms on Earth
Mushrooms add flavor and richness to our food. But do not mess around with them. These five delicious-looking mushrooms could actually be fatal if eaten.
10 Fabulous Houseplants that Work as Living Air Purifiers
Ten common houseplants that keep our indoor air clean and balance the inside humidity. They also help by fighting pollution. Let us find more about them.
Where Are They Now: Modern Day Descendents of 10 Historical Icons
Ten infamous people left a legacy of descendants, still living amongst us. Read to find out where Hitler's relatives live today and more…
13 Most Poisonous Dishes You Can Eat
What is it about living life on the edge that we intelligent humans seek to eat things that could potentially harm us, paralyze us, and maybe even kill us?
10 Hottest Girls With Guns in Movies
In celebration of hot, strong women wielding firearms in movies, we bring you ten iconic girls with guns.


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Shauna Hunt was on scene at Yonge-Dundas Square and she tells you what she saw as the Grey Cup made an appearance during the fan march on Sunday.
Cpl. Nathan Cirillo brought home to Hamilton
The body of Cpl. Nathan Cirillo, gunned down in Ottawa this week,returned to his hometown of Hamilton via the Highway of Heroes on Friday.


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Tengo una banda nueva, Rey en Ruinas, nuestro debut es en noviembre con Solocarne, Endemia y 88 Fingers Louie…esto me hace feliz :)
Day 97 - 88 Fingers Louie - The Dom Years
I'm kicking myself in the head for not doing this band at day 88! /these guys are one of the most energetic bands ever, just listen to them! Behind Bars radiates energy, as does their entire catalog. The Dom years is a showcase of songs with their drummer Dom at the kit. He tears it up on the entire album. Solid, solid album.
1st street
Original Misfits Bullet insert. From the collection of Paul Meslin.
Image found on Fashion, Music & Stuff from the 60's and 70's
Boom. on We Heart It.
I bleed it out…
I've opened up these scars…
I'll make you face this…!
I've pulled myself so far…
I'll make you face this now…!!
- - -
This started out as just some facial expression practice and it quickly turned into an all out photoset. I'm beyond happy with it though, I have a thing for blood so that's always fun to color. Enjoy, you guys !


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Miley cyrus Butterfly Fly Away Ringtone
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Pathfinder Campaign Setting: Inner Sea Bestiary
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This book contains dozens of new monsters found in the Inner Sea region—all invented specifically for the Pathfinder campaign setting! Some, like the gearsmen of Numeria or the moth-like star monarchs who serve the goddess of dreams, have been mentioned many times in Pathfinder Campaign Setting books, but others, like the alien vespergaunt or Rahadoum's desert-dwelling whirlmaws, have only been obliquely illustrated or mentioned before. And some—like the mysterious and ancient veiled masters, and the disturbingly alluring fungus queen—make their appearance for the first time in print after debuting in Paizo's office campaigns.
The Inner Sea Bestiary explores some of Golarion's most unique monsters. Inside this book you will find:
The Inner Sea Bestiary is intended for use with the Pathfinder Roleplaying Game and the Pathfinder campaign setting, but can be used in any fantasy game setting.
By Jim Groves, James Jacobs, Rob McCreary, Erik Mona, Jason Nelson, Patrick Renie, F. Wesley Schneider, James L. Sutter, Russ Taylor, Greg A. Vaughan
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What do the gods of Golarion do?,
Tuoni, mortal lord of the wastes.,
Dominion of the Black - What and where to find more info on them? (Spoilers warning!),
Making a Tiefling / Aasimar Without an Outsider Grandparent,
Dark side of Pathfinder,
Why is arcane magic not completely ubiquitous?,
1001 Rules of Golarion,
Conlanging for Golarion,
[Community Project] Wayfinder #13 Call for Submissions,
Sin magic?,


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34, Saint Paul, MNI totally enjoy the outdoors- I've attended three summer camps and have worked at two of these. While outdoors I enjoy; camping, hiking, alpine skiing, swimming, and but not l...
23, Minneapolis, MNTo put it simply my name is David and I live in Minneapolis with my oldest brother and my niece. Overall I'm an old fashioned person, and when it comes to life in general, all...
39, Minneapolis, MNI would like to knowa lady who wants to share the rest of my life. If you like to know anything about me just ask ?????????????????????????? I love dancing going out try some...
56, Saint Paul, MNI exist in the world, but try to not be of the world (How does St Therese put it, 'The world is thy ship and not thy home'?) . I think as opposed to react, and try to love as ...
32, Minneapolis, MNLets see here... Well, since like most Americans I tend to associate myself with my job a lot I guess I can start by telling you that I am a former paramedic, and current law ...
27, Minneapolis, MNThe "about me" section is always a little awkward, but hey - here goes! I am the kind of person who would much rather have a conversation than write a bio. I try to see the gl...
39, Minneapolis, MNI am a catholic Man who is looking for that special person to share his life with. I am considerate, thoughtful, hardworking. I place other peoples needs before my own. I am a...
48, Minneapolis, MNI am a compassionate Catholic man, I enjoy helping others, and currently I work supporting the elderly and disabled so they can live independently. I enjoy hiking, biking, nat...
28, Minneapolis, MNI'm a single guy in my late 20s. I like to work hard and play hard. When I'm not working, I enjoy getting a drink with friends, hitting the gym, or just having a low-key night...
29, Minneapolis, MNI like to think of myself as the guy at the guy who isn't like all the other ones, and who just needs a chance to prove that. But I'm sure you've heard that one before. Whic...
55, Minneapolis, MNI am a 55 year old single father, my youngest just turned 18 and it's now "daddy time". I am pretty laid back, love all kinds of music, riding my bike around the lakes and jus...
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We remember author & poet Maya Angelou with Gayle King and musician Nas. watch
As Jenna exacts revenge on Liz for her surprise wedding, Jack struggles once again to please his mother. watch
Jenna is furious at Liz for stealing her wedding thunder. Jack devises a plan to avoid disappointing his mother while Tracy tries to cheer up Kenneth. watch
In this week's edition of "Sounds of the Toyota Green Room," actress Naomi Watts talks with Norah O'Donnell about working with Bill Murray in her new film "St. Vincent." LA Clippers owner Steve Ballmer talks with Gayle King about buying the team.
Los Angeles police responded to a call reporting inappropriate sexual behavior in a car. When officeres arrived, Daniele Watts refused to identify herself and claimed to be the target of racial profiling. She has been charged with lewd conduct alongside her boyfriend. Gayle King reports.
Tell-it-like-it-is advice from America's and Oprah's favorite experts.
Brandy has had 5 shots backstage and wants to know how long it takes to sober up
More Clips & Interviews
Academy Award-winners Denzel Washington and Meryl Streep, along with Golden Globe and Emmy nominee Liev Schreiber, mesmerize a whole new generation of audiences in Academy Award winner Jonathan Demme's "The Manchurian Candidate." As the entire nation watches the presidential campaign hurtle towards Election Day, one soldier races to uncover the conspiracy behind it - a conspiracy that seeks to destroy democracy itself.
Two U.S. soldiers in the first Gulf War are programmed to rebel once they return home. Several years later, one becomes a vice presidential candidate.
In the midst of the Gulf War, soldiers are kidnapped and brainwashed for sinister purposes.
More Gayle King Movies Videos
We remember author & poet Maya Angelou with Gayle King and musician Nas.
Simon and the team try an out-of-the-box idea in order to save a library from being shut down, and Gordon literally becomes the unwilling poster boy for the campaign.
Also Available On Amazon Instant Video and VUDU
In the Season Finale, designers present collections inspired by their own heritage at a VIP runway show at the world headquarters of the United Nations. Project Runway's Zac Posen and guest judge Gayle King help to crown the winner.
Also Available On Lifetime, Xfinity, Amazon Instant Video and VUDU
Gayle King joins Larry for a spirited heart-to-heart. The co-host of "CBS This Morning" dishes on her morning show competition, why she won't turn to online dating like Martha Stewart & if she's ever been jealous of her BFF, Oprah Winfrey.
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More Credits (135)
Andy Cohen's welcoming a very special guest to the Watch What Happens Live clubhouse: Oprah Winfrey!
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George Lucas celebrated his recent nuptials to Mellody Hobson with a star-studded party, according to The Hollywood Reporter.
Last weekend, Lucas and Hobson wed at Lucas' Skywalker Ranch in Marin County, Calif., with Ron Howard, Oprah and Steven Spielberg in attendance. On Saturday, the newlyweds held their second reception in Hobson's native Chicago.
read more
The recent birth of Kim Kardashian and Kanye West's baby didn't make it onto CBS This Morning. "We were the only morning show that didn't mention it," coanchor Gayle King says proudly. And that's just fine with the increasing number of fans tuning in to the show that relaunched last year as a newsier, tabloid-free alternative to ABC's Good Morning America and NBC's Today...
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Carrie Underwood and Taylor Swift have a lot in common. Both are beautiful, blonde chart-topping country-pop stars and both, according to reports, hate each other. So are the rumors true?
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Dolly Parton has denied long-circulating speculation that she is gay in a candid interview with Nightline.The legendary singer and gay icon, whose been married to her husband Carl Dean for 46 years, shut down the reports that she is romantically involved with her childhood friend Judy Ogle. In fact, the singer says she has even bonded over the gay rumors with her pal Oprah Winfrey.
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Colin Reitz
From Wikipedia, the free encyclopedia
|Personal information
|April 6, 1960
Medal record
Colin Reitz (born April 6, 1960) is a retired long-distance runner from Great Britain, who represented his native country in the Men's 3,000 metres Steeplechase at the 1984 Summer Olympics. There he finished in fifth place.
Reitz also competed at the 1980 Summer Olympics. He is best known for winning the bronze medal at the inaugural 1983 World Championships in the same event. He set his personal best (8:12.11) in the steeplechase on 5 September 1986 at a meet in Brussels.
- Colin Reitz profile at IAAF
|This biographical article relating to British athletics is a stub. You can help Wikipedia by expanding it.


text: Work-themed Episodes Edit Classic editor History Talk0 17,212 articles beingedited here Category page Sorting type: Most visited Most visited Alphabetical | Episodes that centre around a character's job. Pages in category "Work-themed Episodes" Secrets of a Successful Marriage Marge vs. the Monorail Sideshow Bob Roberts Homer's Enemy You Only Move Twice The Great Louse Detective Homer's Odyssey Oh Brother, Where Art Thou? Donnie Fatso Simpson and Delilah Krusty Gets Kancelled Sex, Pies, and Idiot Scrapes Behind the Laughter New Kids on the Blecch Day of the Jackanapes Realty Bites Back 1 2 3 4 5 Next Retrieved from "http://simpsons.wikia.com/wiki/Category:Work-themed_Episodes?oldid=213897"


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This was one place I have always wanted to see. I enjoyed the drive around the loop around the park, but I don't think I need to see this park again. Glad to check Saguaro off my list.
Very Interesting Cactus of all sorts! The drive was wonderful. Great scenery and viewpoints to take pictures.
If you have the senior pass for national parks, (America The Beautiful, The National Parks and Federal Recreational Lands Pass) you would not have to pay any fees. (but you have to be 62+ for this $10 lifetime pass.)
Just found out this place by luck. Great loop drive to catch a view! 10 US$ for 7 day-pass with a map and a friendly welcome!
Originally me and my wife planned to spend a day at Saguaro East. But we arrived late, so we could only spend half a day there. We had a nice lunch at "Saguaro Corners" restaurant (which is just outside the park with lovely staff) and began our tour. We did the Cactus forest dr, stopped at different locations and did...
Fantastic hills and fauna. We like it alot better in the fall and winter because there is no sun shade under hot tucson sun. Take sun protection. I even wear a visor under my bike helmet because miles 4-6 are hot and sunny. Ecological park was fair but paved which would be nice for wheelchairs. The visitor center has dated...
Saguaro West seems to attract more visitors. The East portion also has great trails for all abilities. Some were closed because of serious erosion but that left plenty to chose from. For non-hikers, there is a nice drive through part of the Park.
Another trip worth taking. This 8 mile driving loop through the park offers many opportunities to get out of your car and hike among the saguaros.
We took advantage of the weather and embarked on one of the shorter hiking trails. It was amazing to be out in the middle of (what felt like) nowhere and really immerse ourselves in...
There are two halves to this park; the west one is further from town, smaller and offers some interesting dirt-road driving opportunities. Too bad i was there late in the day, and the intra-park roads close at dusk. Did not really have time to form an opinion.
The east half of the park sits just at the end of the...
This was a very interesting and informative national park. We were excited the see the Saguaro cactus. It was all around the area but it was so beautiful. Could hardly believe what we were seeing. Would go back!
Petroglyphs, cactus and trails! There were so many saguaro cactus that seemed like they were posing for my camera I took to many pictures. A ton of cool stuff to see here if you are an outdoor person!
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[url=http://www.weddings-portal.com/]Weddings[/url] Portal is a website that was created for the purpose of serve information, articles and news articles about wedding issues. You can read and enjoy our particular types of wedding. now you can visit here.
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01No Waves? No Problem. This Guy Can Turn Any Beach Into A Surfing Nirvana. He Just Needs £50,000...
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088 Unbelievable Beach Bars You Need To Visit Before You Die
09North Face Shoppers In Shock As Shop Floor Disappears Beneath Them
10Skiing Naked And Whacking Poles: G.N.A.R Is The Mountain Game You've Got To Play This Winter…
Red Bull X-Fighters World Tour 2011 Poznan
In front of 35,000 spectators in the City Stadium in Poznan (POL), Nate Adams came up with the big tricks on Saturday to pick up the victory and his 18the career podium in the 10-year history of the Red Bull X-Fighters. The American didn't give his title rival, Dany Torres of Spain, any chance in the final. Eigo Sato of Japan got third place.
Video de motocross par RedBull Medai House
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1968 Mercedes 280SL that can be used as a driver. The car is the rare and desirable color combination of baby blue with a... More
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1962 Mercedes 190SL roadster, super straight, absolutely rust-free, black plate CA car. 85,000 original miles. Beautiful paint, interior, top and chrome. Red with black... More
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1971 Mercedes-Benz 280 SL Red with Tan interior, Very rare 4 Speed, 2 tops Power Steering, Power Brakes, AM/FM Becker radio. Heated rear pane, heated... More
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YouTubers - The Brat Pack for the 21st Century
from Typecast
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Typecast is written by Nickie O'Hara- wife to one, Mum to three and Nana to two. She works full-time while also studying for an Open University degree.
Fast diagnosis - a bit of a reality check.
from Adventures with Dementia
This blogger's a carer for his wife who has young onset dementia. Blogging is therapy for him as he tries to find out more about and raise awareness of this cruel condition.
Strictly come dancing…down the aisle?
from Gransnet Colchester
Twitter: @GNColchester
News from the CO postcode area brought to you by Gransnet Local
No bobbing about for Toffee Apple Cake
from Grandma Abson's Traditional Baking
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I blog about my Grandma Abson's simple, tasty baking and share recipes with culinary nostalgics, baking devotees and anyone new to baking!
Sandown (iow) Competition Entry
from A Nanny's View of Life
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from Life, Love and Laundry
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A blog about life experiences, memories, family and friends by a blogger who's a grandmother and guardian to her two grand-daughters.
from Dreaming in Text
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This blogger's not a Yummy-Mummy, nor a Town to Country, nor a Zimmer-Frame Clubber. She's a fortysomething single woman trapped in a 75-year-old body. This makes for some incongruity in everyday...
from shadow of victory
Life and Grandparenting and parenting from a Christian viewpoint.
from Shadow of Victory
Life as a granny as well as my own life story written from a Christian point of view ....not always about children


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Animal Show: Season 1, Episode 7
Zebra & Lion
TV Episode - Family
(voting begins after release)
Today's special guests are Randall Zebra and Chuck Lion. Stinky is particularly excited about the latter's visit, and dresses up as a circus lion tamer to make him feel more at home. So Jake puts him wise about where lions really live.
Director:Peter Harris
Writers:Jim Lewis, Bill Oddie, 3 more credits »
Stars:Bill Barretta, Dave Goelz, Karen Prell | See full cast and crew »


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How To Play Fish Hunter 2
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Rep. Schiff urges U.S. to cut security assistance to Azerbaijan
December 4, 2012 - 21:10 AMT
PanARMENIAN.Net - U.S. Representative Adam Schiff (D-CA) sent a letter to Senators Patrick Leahy and Lindsey Graham, and Representatives Kay Granger and Nita Lowey – the Chairmen and Ranking Members of the State and Foreign Operations Subcommittees in the House and Senate – calling on them to cut all security assistance to Azerbaijan, including Azerbaijan's International Military Education and Training Account (IMET) funding.
This latest request comes after the egregious repatriation and release of Ramil Safarov, an Azerbaijani army captain who had confessed to the savage 2004 axe murder of Armenian army lieutenant Gurgen Margaryan during a NATO Partnership for Peace Program.
"Azerbaijan has committed the most terrible subversion of justice – making a hero of a cold-blooded killer," said Rep. Schiff. "Plainly the investment we have made in training Azeri forces has been worse than wasted. The United States must not tolerate any acts of aggression against Armenia or Nagorno Karabakh, and this hateful action by President Aliyev undermines all international efforts to bring about a peaceful solution in the region," Rep. Schiff said.
"Azerbaijan must pay a high price for its actions. Baku treasures the security assistance that it receives from Washington, not because it needs the money (it does not), but because it signifies a certain closeness in the bilateral relationship. By cutting off military aid to Azerbaijan, the United States would signal its disgust with the Safarov affair, while also reminding Aliyev that the United States will not tolerate any acts of aggression against Armenia or Nagorno-Karabakh," the letter concluded.
Top stories
"Resolution of the Karabakh conflict depends on political will of the Presidents of Armenia and Azerbaijan," James Warlick said.
Only 60 out of 193 UN General Assembly member states voted for Turkey, while its rival, Spain, received 132 votes.
The monument's designer is Mihran Hakobjan, a 30-year-old Armenian-born artist who graduated from a Slubice college.
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Number of Ebola cases exceeds 10,000: WHO A shortage of labs capable of handling potentially infected blood samples has also made it difficult to track the outbreak.
Iran executes woman despite int'l campaign Jabbari was arrested in 2007 for the murder of Morteza Abdolali Sarbandi, a former employee of Iran's ministry of intelligence.


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Hacked By: DPETTY
Hack Information:
Infinite Tries, Stiff Arms, Spin Moves & Always Running Fast - - - - Extra Hack: For laughs don't press any keys and hit the "left shift" for a Superman Touchdown :D
Requested By: dave51495
Game Information
Run in different directions to escape the opposing team and try to make it into the goal. Touchdown!
NOTE: I realize the game is probably ruined now because of the infinite stiff arms and spins, but that was the users request! Just use one of each if you want more of a challenge!
Cheats: Hackbar: Press [1] Heal - [2] Toggle auto heal
Hacked By: selectLOL
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text:
Swapping food to save the planet
A group of Bairnsdale residents are swapping home-grown produce to fight the supermarket duopoly and save the planet.
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Silverbeet, kale, rosemary, lemons, oranges, lemons, chives and even chokos sit on the produce table outside the Bairnsdale Neighbourhood House.
Locals of all walks of life are welcome to bring along excess produce to swap at the Bairnsdale Street Harvest.
"We have some of the richest people in Bairnsdale come along, we have people who don't have a lot of many, people who come because they don't want to waste things, or want to save the planet... and we have people who just want company," says Christine Watts, Bairnsdale Food Harvest coordinator.
"It's not just about swapping food, it's about learning from each other," Christine says.
Peter brought along a bag of hot and mild chillies.
What is he taking home with him today?
"I've got a couple of limes and some eggs, which I'll put to good use," he says.
Norma will take home a bunch of silverbeet and garlic chives, she swapped for a bag of oranges.
"It's a great way to eat food that is fresh, straight from someone's garden and coming along is a great way to meet new people," Norma says.
The Bairnsdale Street Harvest is held at Bairnsdale Neighbourhood House every Friday at 10am-12pm.
You can find out more about the Bairnsdale Food Harvest here.
Search ABC Local
- Energy and Resource Minister Russell Northe, Labor spokeswoman Lily D'Ambrosio and Economist Rod Campbell talk coal in Victorian election.
- Cage fighting
- Police investigate suspicious fires ahead of bushfire season
- Richard Tejonenne of the Department of Environment and Primary Industries, and Michael Owen of the Country Fire Authority talk upcoming fire season
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|Good Day Phuket Boutique Bed & Breakfast 60/76 M.2 T.Wichit A.Muang, Phuket
Score from 285 reviews: Excellent Latest booking: 11 hours ago There are 2 people looking at this bed and breakfast.Good Day Phuket Boutique Bed & Breakfast features bright and airy rooms with air conditioning and an outdoor pool. Guests enjoy free Wi-Fi. On-site parking is available. More…
$31 Average price per night
|Baan Chang Phuket Bed & Breakfast 23/6 Moo 6, Soi Koktanod 8, Bandon, Cherngtalay, Bang Tao Beach
Score from 26 reviews: Wonderful Latest Booking: October 19Featuring free shuttle services to Layan Beach and free pick-up services from the airport, Baan Chang Phuket Bed & Breakfast also provides spacious rooms with en suite bathrooms. More…
$74 Average price per night
|Southern Fried Rice 100/14-15 kata road, Muang, Phuket, Kata Beach
Latest Booking: October 20Offering a restaurant serving Thai cuisine, Southern Fried Rice is just a 5-minute walk from Kata Beach. It offers accommodation with air conditioning and the convenience of free WiFi access. More…
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Score from 35 reviews: Good Latest booking: 21 hours agoLocated on Patong's lively beach, Patong Beach Bed and Breakfast offers convenience in air conditioned rooms with free Wi-Fi and marble bathrooms. It provides daily breakfast and free parking. More…
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|Svea's Panwa Beach Sea View Resort 38/40 Moo 8, Sadidet road, Wichit, Muang, Phuket, Panwa Beach
Score from 56 reviews: Exceptional Latest Booking: October 19Located on the hill top, Svea's Panwa Beach Sea View Resort is located inside Vanich Bayfront Ville offering panoramic views of the Andaman Sea. It offers air-conditioned rooms with free Wi-Fi. More…
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12/17 NaiYang 13/2, (Soi Kokmort 2), T. Saku, A.Thalang, Phuket, Nai Yang Beach
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text:
M's Prospect Watch: All-Rookie Team
Robert Rohrbaugh, LHP 14 G/12 GS, 5-2, 3.84 ERA, 68 IP, 68 H, 71 K, 18 BB, 7 HR, .262 BAA Clemson product was stellar in Midwest League playoffs after a solid summer in Everett. Ready for the Cal League? Jeff Gilmore, RHP 12 G/8 GS, 5-1, 3.97 ERA, 56.2 IP, 55 H, 57 K< 13 BB, 9 HR, .253 BAA Right-hander from Stanford got comfortable in Everett, becoming one of Pedro Grifol's most reliable arms...
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A scene exactly the same as yesterday This time with the benefit of having done it already , I could afford to go quicker and more assuredly.
I changed the colour of the water to a blue with less yellow in it. I think this one is cleaner too, not by much, but enough to notice.
I had to redo the boat, the first attempt was atrocious! You know the moment you start to fiddle on a part of the painting such as this, it's time to scrape back the offending bit and do it again.


text:
47 events within about 10 miles in the next 4 weeks
Results 26 - 47 : sorted by date
Results 26 - 47 : sorted by date
|Page 2 of 2
Whole Lotta Led
Boutique Gift Markets Boutique Gift Markets
A range of Jewellery, scarves, soaps, wooden name plaques, ceramics, wooden pens & pencils, trinkets, preserves, place-mats and coasters. All in the lovely setting of the Norwegian Church main hall.
Norwegian Church Arts Centre Harbour Drive, Cardiff Bay, Cardiff CF10 4PA
Saturday 25 Oct 2014, Sat 8 Nov, Fri 5 Dec
Wales v Australia
The Ramblers group walk. Distance 10 miles.
Enjoy British wildlife on a Ramblers group walk. Cleeve, Chelvey and Wrington. A fields and woodland walk over many familiar footpaths and some less well-known. Picnic/pub lunch at Wrington. Meet:...
The Ramblers group walk starting point.. Grid Ref: ST159653 Rhondda Cynon Taf CF64 5SZ
Sunday 9 Nov 2014
Paul Foot - Hovercraft Symphony in Gammon # Major
Loveable Rogues
Venetian Snares
Cardiff Gang Show 2014: The Cyberspace Chronicles
Rich Robinson (Of The Black Crowes)
Abba Reuinion
The Doors Alive
Table Top Sale
Wales v Fiji
Dr Feelgood & Nine Below Zero
Ruff Ceilidh
Ruff Ceilidhs – what are they? Well there's a live band with a caller who explains the dances. Other names include Twmpath and Barn-dance, Country dance and also sometimes e-Ceilidh. Its dancing in...
CMC Sports and Social Club on the campus of the University Hospital of Wales, Heath Park, Cardiff, CF14 4XW
Saturday 15 Nov 2014


text:
Are you Aleksandra Isakovic?Claim your profile
Publications (31)101.78 Total impact
Article: Antioxidative Activity of Diarylheptanoids from the Bark of Black Alder (Alnus glutinosa) and Their Interaction with Anticancer Drugs.[Show abstract] [Hide abstract]
ABSTRACT: Diarylheptanoids belong to polyphenols, a group of plant secondary metabolites with multiple biological properties. Many of them display antioxidative, cytotoxic, or anticancer actions and are increasingly recognized as potential therapeutic agents. The aim of this study was to evaluate antioxidant and cytoprotective activity of two diarylheptanoids: platyphylloside 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-β-D-glucopyranoside (1) and its newly discovered analog 5(S)-1,7-di(4-hydroxyphenyl)-5-O-β-D-[6-(E-p-coumaroylglucopyranosyl)]heptane-3-one (2), both isolated from the bark of black alder (Alnus glutinosa). To that end, we have employed a cancer cell line (NCI-H460), normal human keratinocytes (HaCaT), and peripheral blood mononuclear cells. The effects on cell growth were assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Cell death was examined by annexin V/propidium iodide staining on a flow cytometer. Reactive oxygen species production was examined by dihydroethidium staining. Mitochondrial structure and doxorubicin localization were visualized by fluorescent microscopy. Gene expression of manganese superoxide dismutase and hypoxia-inducible factor-1α was determined by reverse transcription polymerase chain reaction. Diarylheptanoids antagonized the effects of either doxorubicin or cisplatin, significantly increasing their IC50 values in normal cells. Diarylheptanoid 1 induced the retention of doxorubicin in cytoplasm and reduced mitochondrial fragmentation associated with doxorubicin application. Diarylheptanoid 2 reduced the reactive oxygen species production induced by cisplatin. Both compounds increased the messenger ribonucleic acid expression of enzymes involved in reactive oxygen species elimination (manganese superoxide dismutase and hypoxia-inducible factor-1α). These results indicate that neutralization of reactive oxygen species is an important mechanism of diarylheptanoid action, although these compounds exert a considerable anticancer effect. Therefore, these compounds may serve as protectors of normal cells during chemotherapy without significantly diminishing the effect of the applied chemotherapeutic.Planta Medica 08/2014; · 2.35 Impact Factor
Article: HER2-POSITIVE BREAST CANCER PATIENTS: CORRELATION BETWEEN MAMMOGRAPHIC AND PATHOLOGICAL FINDINGS.[Show abstract] [Hide abstract]
ABSTRACT: Human epidermal growth factor receptor 2 (HER2)-positive breast cancers represent a highly aggressive breast cancer subtype and are associated with a worse prognosis. This study was designed to investigate the mammography finding of HER2-positive breast cancer and to compare the results with the characteristics of HER2-negative breast cancer patients. From January 2010 to October 2011, mammography findings of 65 patients with pathologically confirmed HER2-positive breast cancers (n = 22) or HER2-negative breast cancers (n = 43) were retrospectively reviewed. The authors also reviewed pathological reports for information on the histological type and differentiation grade. Among the two types of breast cancer patients, estrogen receptor-negative/PR-negative/HER2-positive breast cancer patients most commonly had associated calcifications (18 of 22) on mammography. On mammography, cases with a cluster of calcifications usually were presented as pleomorphic calcifications (12 of 20) and branching calcifications (4 of 20). Patients with HER2-positive breast cancers showed a histological grade II. HER2-positive breast cancer patients usually had ductal invasive carcinoma (17 of 22). Moreover, postmenopausal patients showed a significantly higher frequency of HER2-positive tumours. Our results suggest that the imaging findings might be useful in diagnosing HER2-positive breast cancer patients.Radiation Protection Dosimetry 07/2014; · 0.91 Impact Factor
Article: Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae.[Show abstract] [Hide abstract]
ABSTRACT: Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9α-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.Planta Medica 02/2014; · 2.35 Impact Factor
Article: The Mechanisms of In Vitro Cytotoxicity of Mountain Tea, Sideritis scardica, against the C6 Glioma Cell Line.[Show abstract] [Hide abstract]
ABSTRACT: Sideritis scardica (mountain tea) is an endemic plant on the Balkan Peninsula traditionally used for treating different conditions, mainly of inflammatory nature. This study was aimed to examine the cytotoxic activity of different S. scardica extracts against the rat glioma C6 line and rat astrocytes in primary culture. The obtained data revealed that diethyl ether (extract 2) and ethyl acetate (extract 3) extracts of S. scardica exerted a cytotoxic effect on C6 rat glioma cells. Diethyl ether extract induced an increase in reactive oxygen species production, leading to apoptotic and autophagic cell death. Ethyl acetate extract induced G2 M cell cycle arrest and autophagy. None of the tested extracts was cytotoxic to rat astrocytes in primary culture. Cytotoxic effects of S. scardica extracts were, at least in part, mediated by their flavonoid constituents apigenin and luteolin that, when applied alone, induced cell cycle arrest, apoptosis, and autophagy.Planta Medica 09/2013; · 2.35 Impact Factor
Article: Purine nucleoside analog - sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines.[Show abstract] [Hide abstract]
ABSTRACT: Achieving an effective treatment of cancer is difficult, particularly when resistance to conventional chemotherapy is developed. P-glycoprotein (P-gp) activity governs multi-drug resistance (MDR) development in different cancer cell types. Identification of anti-cancer agents with the potential to kill cancer cells and at the same time inhibit MDR is important to intensify the search for novel therapeutic approaches. We examined the effects of sulfinosine (SF), a quite unexplored purine nucleoside analog, in MDR (P-gp over-expressing) non-small cell lung carcinoma (NSCLC) and glioblastoma cell lines (NCI-H460/R and U87-TxR, respectively). SF showed the same efficacy against MDR cancer cell lines and their sensitive counterparts. However, it was non-toxic for normal human keratinocytes (HaCaT). SF induced caspase-dependent apoptotic cell death and autophagy in MDR cancer cells. After SF application, reactive oxygen species (ROS) were generated and glutathione (GSH) concentration was decreased. The expression of key enzyme for GSH synthesis, gamma Glutamyl-cysteine-synthetase (γGCS) was decreased as well as the expression of gst-π mRNA. Consequently, SF significantly decreased the expression of hif-1α, mdr1 and vegf mRNAs even in hypoxic conditions. SF caused the inhibition of P-gp (coded by mdr1) expression and activity. The accumulation of standard chemotherapeutic agent - doxorubicin (DOX) was induced by SF in concentration- and time-dependent manner. The best effect of SF was obtained after 72 h when it attained the effect of known P-gp inhibitors (Dex-verapamil and tariquidar). Accordingly, SF sensitized the resistant cancer cells to DOX in subsequent treatment. Furthermore, SF decreased the experssion of vascular endothelial growth factor (VEGF) on mRNA and protein level and modulated its secretion. In conclusion, the effects on P-gp (implicated in pharmacokinetics and MDR), GSH (implicated in detoxification) and VEGF (implicated in tumor-angiogenesis and progression) qualify SF as multi-potent anti-cancer agent, which use must be considered, in particular for resistant malignancies.PLoS ONE 01/2013; 8(1):e54044. · 3.53 Impact Factor
Article: Cyclohexyl analogues of ethylenediamine dipropanoic acid induce caspase-independent mitochondrial apoptosis in human leukemic cells.[Show abstract] [Hide abstract]
ABSTRACT: We investigated the cytotoxicity of recently synthesized (S,S)-ethylendiamine-N,N'-di-2-(3-cyclohexyl)propanoic acid esters toward human leukemic cell lines and healthy blood mononuclear cells. Cell viability was assessed by acid phosphatase assay, apoptosis, and differentiation were analyzed by flow cytometry and electron microscopy, while intracellular localization of apoptosis-inducing factor (AIF) was determined by immunoblotting. It was demonstrated that methyl, ethyl, and n-propyl esters were toxic to HL-60, REH, MOLT-4, KG-1, JVM-2, and K-562 leukemic cell lines, while the nonesterified parental compound and n-butyl ester were devoid of cytotoxic action. The ethyl ester exhibited the highest cytotoxic activity (IC₅₀ 10.7 μM-45.4 μM), which was comparable to that of the prototypical anticancer drug cisplatin. The observed cytotoxic effect in HL-60 cells was associated with an increase in superoxide production and mitochondrial membrane depolarization, leading to apoptotic cell death characterized by phosphatidylserine externalization and DNA fragmentation in the absence of autophagic response. DNA fragmentation preceded caspase activation and followed AIF translocation from mitochondria to nucleus, which was indicative of caspase-independent apoptotic cell death. HL-60 cells treated with subtoxic concentration of the compound displayed morphological signs of granulocytic differentiation (nuclear indentations and presence of cytoplasmic primary granules), as well as an increased expression of differentiation markers CD11b and CD15. The cyclohexyl analogues of ethylenediamine dipropanoic acid were also toxic to peripheral blood mononuclear cells of both healthy controls and leukemic patients, the latter being more sensitive. Our data demonstrate that the toxicity of the investigated cyclohexyl compounds against leukemic cell lines is mediated by caspase-independent apoptosis associated with oxidative stress, mitochondrial dysfunction, and AIF translocation.Chemical Research in Toxicology 03/2012; 25(4):931-9. · 3.67 Impact Factor
Article: Arylpiperazine dopamineric ligands protect neuroblastoma cells from nitric oxide (NO)-induced mitochondrial damage and apoptosis.[Show abstract] [Hide abstract]
ABSTRACT: The protective ability of novel arylpiperazine-based dopaminergic ligands against nitric oxide (NO)-mediated neurotoxicity is investigated. The most potent neuroprotective arylpiperazine identified during the study was N-{4-[2-(4-phenyl-piperazin-1-yl)ethyl]-phenyl}picolinamide, which protected SH-SY5Y human neuron-like cells from the proapoptotic effect of NO donor sodium nitroprusside (SNP) by decreasing oxidative stress, mitochondrial membrane depolarization, caspase activation and subsequent phosphatydilserine externalization/DNA fragmentation. The protective effect was associated with the inhibition of proapoptotic (JNK, ERK, AMPK) and activation of antiapoptotic (Akt) signaling pathways, in the absence of interference with intracellular NO accumulation. The neuroprotective action of arylpiperazines was shown to be independent of dopamine receptor binding, as it was not affected by the high-affinity D₁/D₂ receptor blocker butaclamol. These results reported support the further study of arylpiperazines as potential neuroprotective agents.ChemMedChem 03/2012; 7(3):495-508. · 2.84 Impact Factor
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ABSTRACT: Sideritis scardica Griseb. (ironwort, mountain tea), an endemic plant of the Balkan Peninsula, has been used in traditional medicine in the treatment of gastrointestinal complaints, inflammation, and rheumatic disorders. This study aimed to evaluate its gastroprotective and anti-inflammatory activities. Besides, continuously increasing interest in assessing the role of the plant active constituents preventing the risk of cancer was a reason to make a detailed examination of the investigated ethanol, diethyl ether, ethyl acetate, and N-butanol extracts regarding cytotoxicity. Oral administration of the investigated extracts caused a dose-dependent anti-inflammatory effect in a model of carrageenan-induced rat paw edema. Gastroprotective activity of the extracts was investigated using an ethanol-induced acute stress ulcer in rats. The cytotoxic activity of plant extracts was assessed on PBMC, B16, and HL-60 cells and compared to the cytotoxicity of phenolic compounds identified in extracts. Apoptotic and necrotic cell death were analyzed by double staining with fluoresceinisothiocyanate (FITC)-conjugated annexin V and PI. The developed HPLC method enabled qualitative fingerprint analysis of phenolic compounds in the investigated extracts. Compared to the effect of the positive control, the anti-inflammatory drug indomethacine (4 mg/kg), which produced a 50 % decrease in inflammation, diethyl ether and N-butanol extracts exhibited about the same effect in doses of 200 and 100 mg/kg (53.6 and 48.7 %; 48.4 and 49.9 %, respectively). All investigated extracts produced dose-dependent gastroprotective activity with the efficacy comparable to that of the reference drug ranitidine. The diethyl ether extract showed significant dose-dependent cytotoxicity on B16 cells and HL-60 cells, decreasing cell growth to 51.3 % and 77.5 % of control, respectively, when used at 100 µg/mL. It seems that phenolic compounds (apigenin, luteolin, and their corresponding glycosides) are responsible for the diethyl ether extract cytotoxic effect. It also appears that induction of oxidative stress might be involved in its cytotoxicity, since B16 and HL-60 cells increased their ROS production in response to treatment with diethyl ether extract. Neither of the tested extracts nor any phenolic compounds showed significant cytotoxic effect to human PBMC. These results demonstrated the potent anti-inflammatory and gastroprotective activities, as well as the promising cytotoxicity.Planta Medica 01/2012; 78(5):415-27. · 2.35 Impact Factor
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ABSTRACT: Human equilibrative nucleoside transporters (hENTs) 1-3 and human concentrative nucleoside transporters (hCNTs) 1-3 in the human choroid plexus (hCP) play a role in the homeostasis of adenosine and other naturally occurring nucleosides in the brain; in addition, hENT1, hENT2 and hCNT3 mediate membrane transport of nucleoside reverse transcriptase inhibitors that could be used to treat HIV infection, 3'-azido-3'-deoxythymidine, 2'3'-dideoxycytidine and 2'3'-dideoxyinosine. This study aimed to explore the expression levels and functional activities of hENTs 1-3 and hCNTs 1-3 in human choroid plexus. Freshly-isolated pieces of lateral ventricle hCP, removed for various clinical reasons during neurosurgery, were obtained under Local Ethics Committee approval. Quantification of mRNAs that encoded hENTs and hCNTs was performed by the hydrolysis probes-based reverse transcription real time-polymerase chain reaction (RT-qPCR); for each gene of interest and for 18 S ribosomal RNA, which was an endogenous control, the efficiency of PCR reaction (E) and the quantification cycle (Cq) were calculated. The uptake of [(3)H]inosine by the choroid plexus pieces was investigated to explore the functional activity of hENTs and hCNTs in the hCP. RT-qPCR revealed that the mRNA encoding the intracellularly located transporter hENT3 was the most abundant, with E(-Cq )value being only about 40 fold less that the E(-Cq )value for 18 S ribosomal RNA; mRNAs encoding hENT1, hENT2 and hCNT3 were much less abundant than mRNA for the hENT3, while mRNAs encoding hCNT1 and hCNT2 were of very low abundance and not detectable. Uptake of [(3)H]inosine by the CP samples was linear and consisted of an Na(+)-dependent component, which was probably mediated by hCNT3, and Na(+)-independent component, mediated by hENTs. The latter component was not sensitive to inhibition by S-(4-nitrobenzyl)-6-thioinosine (NBMPR), when used at a concentration of 0.5 muM, a finding that excluded the involvement of hENT1, but it was very substantially inhibited by 10 muM NBMPR, a finding that suggested the involvement of hENT2 in uptake. Transcripts for hENT1-3 and hCNT3 were detected in human CP; mRNA for hENT3, an intracellularly located nucleoside transporter, was the most abundant. Human CP took up radiolabelled inosine by both concentrative and equilibrative processes. Concentrative uptake was probably mediated by hCNT3; the equilibrative uptake was mediated only by hENT2. The hENT1 transport activity was absent, which could suggest either that this protein was absent in the CP cells or that it was confined to the basolateral side of the CP epithelium.Cerebrospinal Fluid Research 01/2010; 7:2. · 1.81 Impact Factor
- Planta Medica - PLANTA MED. 01/2009; 75(09).
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ABSTRACT: The brain efflux index (BEI), a measurement of blood-brain barrier (BBB) efflux transport, was estimated at 15 s, 30 s, 1 min, 3 min and 10 min after intracerebral injection of [14C]pyrimidines. An initial steep increase of the BEI values over time was observed for [14]uracil and [14C]thymine, followed by a more moderate increase after 1 min. For the corresponding nucleosides, [14C]uridine and [14C]thymidine, the increase of BEI values over time was less steep and linear between 30 s and 3 min. The apparent BBB efflux clearances for [14C]uridine, [14C]thymidine, [14C]uracil and [14C]thymine were (microl/min/g): 95.2 +/- 12.1, 125.3 +/- 18.4, 290.4 +/- 28 and 358.5 +/- 32.5, respectively, which is at least several folds higher than the predicted BBB influx clearances of uridine, uracil and thymidine. Quick depletion of brain parenchyma from brain microvasculature has revealed that [14C] radioactivity accumulated in brain microvessels after injection of nucleosides [14C]thymidine and [14C]uridine, but that was not observed when nucleobases, [14C]thymine and [14C]uracil, were injected. Reverse transcriptase-PCR revealed that the rat brain and liver (positive control) express dihydropyrimidine dehydrogenase, a key enzyme in pyrimidine nucleobase catabolism. Two bands representing spliced variants have been detected with the relative density of the bands (expressed relative to the density of glyceraldehyde3-phosphate dehydrogenase bands, mean +/- SEM from 3 separate samples) 0.16 +/- 0.06 and 0.04 +/- 0.01 (brain) and 0.49 +/- 0.1 and 0.07 +/- 0.01 (liver). Overall, these results indicate that the net direction of pyrimidine BBB transport is the efflux transport; rapid BBB efflux transport and metabolic breakdown of pyrimidine nucleobases appear to be important for brain homeostasis.Neurochemical Research 09/2008; 34(3):566-73. · 2.13 Impact Factor
Article: Adenosine rescues glioma cells from cytokine-induced death by interfering with the signaling network involved in nitric oxide production.[Show abstract] [Hide abstract]
ABSTRACT: We investigated the influence of adenosine on inducible nitric oxide (NO) synthase (iNOS)-dependent NO synthesis and viability of cytokine-treated C6 rat glioma cells. Adenosine significantly inhibited interferon-gamma (IFN-gamma)+interleukin-1beta (IL-1beta)-induced synthesis of iNOS mRNA/protein and subsequent production of NO in C6 cells. The uptake of adenosine into glioma cells was not required for the suppression of iNOS induction, as confirmed by the inability of the adenosine transport blocker nitrobenzylthyoinosine to block the observed effect. Adenosine also blocked the IFN-gamma+IL-1beta-triggered expression of mRNA for the proinflammatory cytokine TNF-alpha, while it significantly enhanced the accumulation of cyclooxygenase-2 (COX-2) mRNA in glioma cells. However, blockade of TNF-alpha action and COX-2 activity with anti-TNF-alpha antibodies and indomethacin, respectively, revealed that modulation of TNF-alpha and COX-2 was not involved in adenosine-mediated iNOS suppression. Adenosine significantly inhibited cytokine-induced activation of mitogen-activated protein kinase (MAPK) family members p38 MAPK, p42/44 MAPK and c-Jun N-terminal kinase (JNK) in C6 cells. The levels of transcription factors IRF-1 and c-Fos, as well as the phosphorylation of c-Jun were also reduced in adenosine-treated C6 cells, while the activation of NF-kappaB was enhanced via increased phosphorylation of its inhibitory unit IkappaB. Importantly, adenosine-mediated suppression of NO release rescued glioma cells from NO-dependent cytokine cytotoxicity. These data suggest a possible role for adenosine-mediated inhibition of glial NO synthesis in regulation of the inflammatory CNS damage and brain cancer progression.European Journal of Pharmacology 07/2008; 591(1-3):106-13. · 2.59 Impact Factor
Article: Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.[Show abstract] [Hide abstract]
ABSTRACT: The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G(2)/M and G(0)/G(1) phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G(2)/M cell block and apoptotic cell death in glioma cells.Bioorganic & medicinal chemistry 06/2008; 16(10):5683-94. · 2.82 Impact Factor
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ABSTRACT: PurposE: The fullerene (C60/C70 mixture-C60/70) nanocrystalline suspension prepared by solvent exchange method using tetrahydrofyran (THF/nC60/70) and polyhydroxylated C60/70 [C60/70(OH)n] were compared for their ability to modulate cytotoxicity of the proinflammatory cytokine tumor necrosis factor (TNF). TNF-induced cytotoxicity was assessed in L929 fibrosarcoma cells by crystal violet assay. The type of cell death (apoptosis/necrosis), production of reactive oxygen species, mitochondrial depolarization and caspase activation were determined by flow cytometry using the appropriate reporter dyes. THF/nC60/70 augmented, while C60/70(OH)n reduced the cytotoxicity of TNF. The numbers of cells undergoing apoptosis/necrosis, as well as of those displaying the activation of apoptosis-inducing enzymes of caspase family, were respectively increased or reduced by THF/nC60/70 or C60/70(OH)n. The antioxidant N-acetylcysteine and mitochondrial permeability transition inhibitor cyclosporin A each partly blocked the cytotoxic action of TNF, indicating the involvement of oxidative stress and mitochondrial dysfunction in the TNF cytotoxicity. Accordingly, THF/nC60/70 or C60/70(OH)n potentiated or suppressed, respectively, TNF-triggered oxidative stress and mitochondrial depolarization. The ability of different fullerene preparations to modulate TNF-induced oxidative stress and subsequent cell death suggests their potential value in the TNF-based cancer therapy or prevention of TNF-dependent tissue damage.Pharmaceutical Research 06/2008; 25(6):1365-76. · 4.74 Impact Factor
Article: Transport of [14C]hypoxanthine by sheep choroid plexus epithelium as a monolayer in primary culture: Na+-dependent and Na+-independent uptake by the apical membrane and rapid intracellular metabolic conversion to nucleotides.[Show abstract] [Hide abstract]
ABSTRACT: Hypoxanthine is the main product of purine metabolic degradation and previous studies have revealed that it is present in the sheep CSF and plasma in micromolar concentrations. The aim of this study was to elucidate the transport of this molecule across the sheep choroid plexus epithelium (CPE) as a monolayer in primary culture, to explore the mechanism of uptake by the apical side of the CPE and investigate the metabolic changes inside the cell. The estimated permeability of the CPE monolayer for [14C]hypoxanthine, [14C]adenine and [14C]guanine was low and comparable to the permeability towards the extracellular space markers. The study of [14C]hypoxanthine uptake by the CPE revealed two components: Na+-dependent and Na+-independent, the latter being partially mediated by the equilibrative nucleoside transporter 2. HPLC with simultaneous detection of radioactivity revealed that the majority of [14C]hypoxanthine inside the CPE is metabolised into [14C]nucleotides and [14C]inosine. The remaining intact [14C]hypoxanthine was transported across the opposite, basolateral side of CPE and appeared in the lower chamber buffer together with [14C]inosine. These findings indicate two possible roles of hypoxanthine uptake from the CSF by the CP epithelium in vivo: to provide material for nucleotide synthesis through the salvage pathways in the CPE, as well as to transfer excess hypoxanthine from CSF to blood.Neuroscience Letters 02/2008; 431(2):135-40. · 2.03 Impact Factor
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ABSTRACT: Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental analysis and mathematical modelling, we investigate the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC(60) suspensions, prepared by solvent exchange method in tetrahydrofuran (THF/nC(60)) and ethanol (EtOH/nC(60)), or by extended mixing in water (aqu/nC(60)). With regard to their capacity to generate ROS and cause mitochondrial depolarization followed by necrotic cell death, the nC(60) suspensions are ranked in the following order: THF/nC(60)>EtOH/nC(60)>aqu/nC(60). Mathematical modelling of singlet oxygen ((1)O(2)) generation indicates that the (1)O(2)-quenching power (THF/nC(60)<EtOH/nC(60)<aqu/nC(60)) of the solvent intercalated in the fullerene crystals determines their ability to produce ROS and cause cell damage. These data could have important implications for toxicology and biomedical application of colloidal fullerenes.Biomaterials 12/2007; 28(36):5437-48. · 8.31 Impact Factor
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ABSTRACT: Using the rat glioma cell line C6 and the human glioma cell line U251, we demonstrate the multiple mechanisms underlying the in vitro anticancer effects of the C(60) fullerene water suspension (nano-C(60) or nC(60)) produced by solvent exchange method. Nano-C(60) in a dose-dependent manner reduced the tumor cell numbers after 24 h of incubation. The observed antiglioma action of nC(60) at high concentration (1 microg/ml) was due to a reactive oxygen species-mediated necrotic cell damage that was partly dependent on oxidative stress-induced activation of extracellular signal-regulated kinase (ERK). On the other hand, low-dose nC(60) (0.25 microg/ml) did not induce either necrotic or apoptotic cell death, but caused oxidative stress/ERK-independent cell cycle block in G(2)/M phase and subsequent inhibition of tumor cell proliferation. Treatment with either high-dose or low-dose nC(60) caused the appearance of acidified intracytoplasmic vesicles indicative of autophagy, but only the antiglioma effect of low-dose nC(60) was significantly attenuated by inhibiting autophagy with bafilomycin A1. Importantly, primary rat astrocytes were less sensitive than their transformed counterparts to a cytostatic action of low-dose nC(60). These data provide grounds for further development of nC(60) as an anticancer agent.European Journal of Pharmacology 08/2007; 568(1-3):89-98. · 2.59 Impact Factor
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ABSTRACT: We demonstrate the capacity of an herbal anthraquinone aloe emodin to reduce the cytotoxicity of the proinflammatory cytokine tumor necrosis factor (TNF) towards L929 mouse fibrosarcoma and U251 human glioma cell lines. Aloe emodin inhibited both TNF-induced cell necrosis and apoptosis, but it did not reduce cell death induced by UV radiation or hydrogen peroxide. Aloe emodin inhibited both basal and TNF-triggered activation of extracellular signal-regulated kinase (ERK), and a selective blockade of ERK activation mimicked the cytoprotective action of the drug. On the other hand, aloe emodin did not affect TNF-induced activation of p38 mitogen-activated protein kinase or generation of reactive oxygen species. The combination of aloe emodin and TNF caused an intracellular appearance of acidified autophagic vesicles, and the inhibition of autophagy with bafilomycin or 3-methyladenine efficiently blocked the cytoprotective action of aloe emodin. These data indicate that aloe emodin could prevent TNF-triggered cell death through mechanisms involving induction of autophagy and blockade of ERK activation.European Journal of Pharmacology 08/2007; 568(1-3):248-59. · 2.59 Impact Factor
Article: Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.[Show abstract] [Hide abstract]
ABSTRACT: The present study reports for the first time a dual antiglioma effect of the well-known antidiabetic drug metformin. In low-density cultures of the C6 rat glioma cell line, metformin blocked the cell cycle progression in G(0)/G(1) phase without inducing significant cell death. In confluent C6 cultures, on the other hand, metformin caused massive induction of caspase-dependent apoptosis associated with c-Jun N-terminal kinase (JNK) activation, mitochondrial depolarization and oxidative stress. Metformin-triggered apoptosis was completely prevented by agents that block mitochondrial permeability transition (cyclosporin A) and oxygen radical production (N-acetylcisteine), while the inhibitors of JNK activation (SP600125) or glycolysis (sodium fluoride, iodoacetate) provided partial protection. The antiglioma effect of metformin was reduced by compound C, an inhibitor of AMP-activated protein kinase (AMPK), and was mimicked by the AMPK agonist AICAR. Similar effects were observed in the human glioma cell line U251, while rat primary astrocytes were completely resistant to the antiproliferative and proapoptotic action of metformin.Cellular and Molecular Life Sciences CMLS 06/2007; 64(10):1290-302. · 5.62 Impact Factor
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ABSTRACT: We investigated the effect of gamma-irradiation on the cytotoxicity of pure C60 solubilized in water by using tetrahydrofuran (THF/n-C60 or THF/n-C60). In contrast to THF/n-C60, its gamma-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, gamma-irradiated THF/n-C60 protected cells from the oxidative stress induced by native THF/n-C60 or hydrogen peroxide. The observed biological effects were associated with gamma-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C60 surface. These results for the first time demonstrate gamma-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.Biomaterials 11/2006; 27(29):5049-58. · 8.31 Impact Factor
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University of Belgrade
Beograd, Central Serbia, Serbia
- • School of Medicine
- • Institute of Microbiology and Immunology
Kuwait University
Kuwait, Muhafazat al `Asimah, Kuwait
- Department of Physiology
Institute for Educational Research, Belgrade, SerbiaBeograd, Central Serbia, Serbia
Vinča Institute of Nuclear Sciences
Beograd, Central Serbia, Serbia
- Department of Radiation Chemistry and Physics


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09 January 2014 at 7:43 PM
Ellie Goulding: Brit Awards Nominations - See Complete List Here!
About this photo set: Ellie Goulding arrives looking gorgeous on the red carpet at the BRIT awards nominations held at ITV Studios on Thursday (January 9) in London, England. The 27-year-old… Read More Here
Posted to Ellie Goulding, Jessie J, Pixie Lott, Tinie Tempeh


text:
Final Test - Hard
|Name: _________________________
|Period: ___________________
This test consists of 5 short answer questions and 1 (of 3) essay topics.
Short Answer Questions
1. How did the thing Terry cooked for Hank's birthday turn out?
2. What did Diane and Terry make a pact about?
3. Whose house hosted the holiday in the Great Horned Owl chapter?
4. What did the LDS church pray for on May 5, 1986?
5. What did Terry say was so great about the petroglyphs?
Essay Topics
Essay Topic 1
What are some of the different birds spoken of in this book, and what significance do they have in the author's life?
Essay Topic 2
Why did Diane refuse medical treatment, and what effect did this have on her family?
Essay Topic 3
How did Terry deal with the sadness of her mother's death, and what does this reveal about her personality?
This section contains 651 words
(approx. 3 pages at 300 words per page)


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Hi there at our free ringtones website, where you can easily use ringtones for free for your mobile. Today we have a ringtone of "Vegas" by Jesper Kyd as well as 278 other ringtones by Jesper Kyd. "Vegas" is a real hit from the "Hitman: Blood Money" album that was produced by Jesper Kyd at their recording studio together with other 6 tracks. You can listen to all 8 Jesper Kyd – "Vegas" ringtone variations available here and download it for free directly to your smart phone. You can also get other 7 albums produced by Jesper Kyd for all time. "Vegas" is referred to Soundtrack, and we have a huge amount of Soundtrack artists absolutely for free. And finally, we have collected lyrics for this track and you can view it here as well. So feel free to browse, listen, download ringtones at Audiko.net. Make your phone sound cool!
Jesper Kyd Vegas Ringtone
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Ambient Danish Electronic Game Game Music Game Soundtrack OST Soundtrack Video Game Music hitman
Albums by Jesper Kyd
Borderlands 2 Original Soundtrack
Jesper Kyd
18 Sep 2012
Jesper Kyd
16 Nov 2010
Top ringtones by Jesper Kyd
- Jesper Kyd - Ezio's Family
- Jesper Kyd - Assasins Creed
- Jesper Kyd - Hitman 2 Main Title
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- Jesper Kyd - Ezio's Family (OST Assassin's Creed II)
- Jesper Kyd - Leap of Faith
- Jesper Kyd - Vegas
- Jesper Kyd - Apocalypse
- Jesper Kyd - Access the Animus
- Jesper Kyd - Assassin's Creed Cello Trailer Theme
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- TIZIANO FERRO - Senza scappare mai più
- Gold AG ft Ganimete Abazi & Ilirët - Fjalët e qiririt
- Gianni Morandi - Ma chi se ne importa


text:
Vatican confirms dates for Pope's second trip to Asia
July 29, 2014 - 15:51 AMT
PanARMENIAN.Net - The Vatican has confirmed the dates for Pope Francis' second trip to Asia, a weeklong visit Jan 12-19 to Sri Lanka and the Philippines, according to the Associated Press.
Francis had already announced his intention to visit Sri Lanka and meet with victims of Typhoon Haiyan, which killed some 6,300 people, left another 1,060 missing and devastated parts of the central Philippines last year.
The Vatican press office said Tuesday, July 29, that Francis would visit Sri Lanka Jan. 12-15, and spend the remainder of the trip in the Philippines. The full program will be released later.
Francis will become the first pope in nearly two decades to visit the Far East when he travels to South Korea Aug 14-18. He has said he wants to visit Asia since Pope Benedict XVI never got there.
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