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In October 2013, dozens of cancer survivors from Smilow Cancer Hospital, along with family, friends and caregivers, gathered on Water Street in New Haven to share in the spirit of community. The project they participated in was the painting of a mural. They battled some of the most difficult forms of cancer. Yet thanks to the amazing advances we have made in research and treatment, and through their own remarkable determination, they came together to beautify a neighborhood. And they delivered a powerful message: That cancer can be beaten. And that through science, compassion and the sheer belief in what is possible, the world is closer to free.
YNHH's Care Coordination program reduces patient readmissions to the hospital.
Right: Grace Jenq, MD
Using the only imaging technology of its kind in the world, YNHH neurosurgeons achieve remarkable successes.
Left: Philip S. Dickey, M.D. Right: Ketan R. Bulsara, M.D.


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Heart Disease Health Center
Cardiac Stents Overview
Types of Heart Stents continued...
In 1986, French researchers implanted the first stent into a human coronary artery. In 1994, the FDA approved the first heart stent for use in the U.S.
First-generation stents were made of bare metal. Although bare-metal stents almost eliminated the risk of the artery collapsing, they only modestly reduced the risk of restenosis. About 25% of all coronary arteries treated with bare-metal stents would close up again, usually within about six months.
So doctors and companies began testing stents which were coated with drugs that interrupted the process of restenosis. These are called drug-eluting stents, which are now approved by the FDA.
In clinical trials, drug-eluting stents dramatically reduced the rate of restenosis to less than 10%. Drug-eluting stents also reduced the need for repeat procedures in patients with diabetes, a condition associated with an increased risk of restenosis.
Despite these benefits, there were concerns that drug-eluting stents were associated with a rare but serious complication: late in-stent thrombosis, in which a blood clot forms inside the stent one or more years after it's implanted. Because this complication can be fatal, it is extremely important that patients with drug-eluting stents take aspirin and an anticlotting drug such as Plavix, Effient (prasugrel), or Ticlid (ticlopidine) as prescribed, and not stop them without their doctor's approval.
Innovations in Heart Stents
Due to concerns such as late in-stent thrombosis, the use of drug-eluting stents started to decline in late 2006. But many cardiologists believed that fears were overblown. They also began to re-examine whether drug-eluting stents were significantly more effective than the older bare-metal stents, especially in patients with blockages that were deemed to have a low risk of restenosis.
In December 2006, the FDA held a public meeting on the issue of late in-stent thrombosis. While concluding that more information was needed, the agency stated that drug-eluting stents, when used as directed, were not associated with an increased risk of heart attack or death. Subsequent research studies confirmed the safety and effectiveness of drug-eluting stents, prompting the continued development of new stent technologies.
In recent years, the usage of drug-eluting stents has steadily increased, and the global market for heart stents is expected to exceed $8 billion by the year 2015.
Many new second- and third-generation stent designs are under development, in clinical trials, or have been approved for use outside the U.S. These include:
- A stent with a covering that delivers an anti-restenosis drug over a period of several months and then essentially becomes a bare-metal stent
- A stent that is absorbed by the body and disappears after it has done its work
- A stent which uses a bio-engineered coating to quickly create a thin, all-natural layer inside the artery
Other technologies under development include platinum-coated stainless steel stents, diamond carbon-coated stents, and gene therapy/antibody-coated stents.
WebMD Medical Reference


text: Helix Blue B FOUR 4-channel car amplifier 60 watts RMS x 4 Zoom Front Left Right Photos Videos My vehicle's homepage We don't check this item for fit or compatibility. Item #: 975BFOUR Review Summary 3 people say Low Stock $379.99 Was: -$38.00 : Outlet Savings Free Crutchfield lifetime tech support Free Shipping Open Box Price Loading... $341.99 Add to cart + Add to wishlist Email me alerts for this product $379.99 New Stock Buy this item and earn up to 342 Rewards points See more offers and ways to save Special Financing Available x By buying this product you'll earn up to 342 Rewards points. When you sign up for a Crutchfield account, you'll be enrolled in Crutchfield Rewards. You'll earn one point for every dollar you spend on gear from us. You can turn your points into Rewards Cards that you can use toward future purchases. You can sign up for an account now, or after you complete your purchase (you'll get credit for the points either way). Sign up for a Crutchfield account Overview Details Customer Reviews Q&A Articles & Videos Accessories Our take on the Helix Blue B FOUR by Buck Pomerantz My system has plenty of power. Who needs an amp? You might think you don't need an amp because you have a 400-watt system in your car, or because your new stereo puts out 50 watts a channel. But those are peak wattage ratings, which may boil down to 15 or 20 watts per channel, using the more realistic RMS rating. An amp sends your speakers the power they need to deliver your music with clarity and impact, whether you're using factory speakers or high-performance components. And low-frequency reproduction requires lots of power, so an amp is an absolute must if you're adding a sub to your system. Clean lines and solid power German engineering and craftsmanship combine to create a sleek amplifier that'll make your vehicle come alive with crystal-clear, powerful music. The Helix Blue B FOUR 4-channel amplifier puts out 60 watts RMS each to your full-range speakers, both front and rear. Or, you can use the B FOUR in 2-channel mode to power a couple of subwoofers with up to 180 watts RMS each. Made for high quality sound The Helix Blue B FOUR amp starts with a noise-free input stage, then uses proprietary technology to achieve an incredible level of acoustic accuracy. The attention to detail extends down to the superior internal components, specially "surface-mounted" to double-sided, copper-plated circuit boards, all contributing to superb sound quality. A big, heavy wrap-around heatsink dissipates the heat for cool, reliable play. B FOUR features You'll find the tools you need to shape your sound. The wide range of the high- and low-pass filters allows you to adjust for the best possible performance from different types of speakers. A bass boost will add even more bang, if you want it to. Amp for a Helix factory upgrade system The B FOUR can also serve as an amp in a Helix Plug and Play factory upgrade system. You can use an EPC5 Easy Plug Cable and a Helix vehicle-specific adapter harness to plug your B FOUR directly into your vehicle's stereo to get its input signal, with no wire-cutting or splicing necessary. See more info on this item Highlights:4-channel car amplifier60 watts RMS x 4 at 4 ohms (90 watts x 4 at 2 ohms)180 watts RMS x 2 bridged output at 4 ohms (4-ohm stable in bridged mode)Class A/B designvariable low-pass filter (15-4000 Hz)variable high-pass filter (40-4000 Hz)bass boost (0-18 dB at 45 Hz )speaker-level inputs via 8-pin harnesspreamp inputs and outputs8-gauge power and ground leads recommended wiring and hardware not included with amplifierfuse rating: 25A x 214-1/4"W x 2"H x 10-1/4"Dwarranty: 2 yearsOur 60-day money-back guarantee Hands-on research from the Crutchfield Labs (what are the Labs?) Features and specs chart | What's in the box? | In-depth notes Features and Specs Performance RMS Power Output (Watts x Channels) 60 x 4 Peak Power Output (Watts x Channels) 180 x 4 Power at 2 Ohms (Watts x Channels) 90 x 4 Bridged Power (Watts x Channels) 180 x 2 Minimum Impedance Bridged 4 Minimum Impedance Unbridged 2 Best Frequency Response 10-30k Hz THD at Rated RMS Power 0.03% Signal to Noise Ratio 95 dB Input Voltage --- Features Amplifier Class AB Low-Pass Crossover Frequency 40-4000 Hz Low-Pass Slope (dB/octave) N/A High-Pass Crossover Frequency 15-4000 Hz High-Pass Slope (dB/octave) N/A Bass Boost 0-18 dB Bass Boost Frequency 45 Hz Fan Cooled No Fuse Rating 50 Speaker Level Inputs Harness Preamp Outputs 1 pair Width (inches) 14-1/4 Height (inches) 2 Depth (inches) 10-1/4 Parts Warranty 2 Years Labor Warranty 2 Years Product Research What's in the box? Download owner's manual Four-channel amplifier Two 25 amp ATO fuses (installed) Four 3/4" Self-tapping screws 8" Speaker-level input harness (Molex plug on one end) 4mm Allen wrench 2mm Allen wrench Instruction manual (German/ English) Our Product Research Team At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team — they open the box, verify contents, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices. Features Controls Connections Features 2-Ohm Stable: In stereo mode (powering four speakers) the amplifier is stable down to 2-ohms. The 2-ohm output is 90 Watts RMS x 4 channels. Bridgeable: The B FOUR can be bridged to two channels, outputting 180 Watts x 2-channels into 4 ohms. You can also wire the B FOUR in three channel mode, bridging half the amp and running the other half in stereo (60 Watts RMS x 2 channels plus 180 Watts x 1-channel). Protection Circuitry: The B FOUR offers four protection circuits: short circuit (or too low an impedance on the outputs), thermal overload, over voltage, and under voltage. Controls 4-Channel: The amplifier is divided into two sections, channels 1/2 and channels 3/4. Each pair of channels has independent gain, bass boost, and crossover controls. Crossover: The built-in crossovers have three position switches to select the crossover operation as high-pass, full-range, or low-pass. The high-pass crossover points are continuously variable from 15 Hz to 4 kHz. The low-pass crossover points are continuously variable from 40 Hz to 4 kHz. Note: When a crossover switch is in the low-pass position, the high-pass frequency dial is also active. Depending on the high-pass frequency setting, this creates either a subsonic filter (useful for any subwoofer and often necessary for ported enclosures) or a band-pass crossover (with a lower limit from 15 Hz to 4 kHz, and an upper limit from 40 Hz to 4 kHz). Gain: The rotary gain controls are continuously variable from 0.2 volts to 6.0 volts to match the source signal. Bass Boost: The bass boost circuits are centered at 45 Hz and continuously variable from 0 dB to +18 dB. Connections Power: The power and ground inputs are set-screw terminals; they will accept bare wire up to 4-gauge (HELIX recommends 8-gauge minimum) and are tightened/loosened with the supplied 4mm Allen wrench. Remote: The remote turn-on input is a set screw terminal; it will accept bare wire up to 10-gauge and is tightened/loosened with the supplied 2mm Allen wrench. Speaker Outputs: The speakers connect to four pair of set-screw terminals; they accept bare wire up to 10-gauge and are tightened/loosened with the supplied 2mm Allen wrench. Line Input: Two pair of stereo RCA jacks connect to the output signal from the head unit. Speaker Level Input: Use the included harness when speaker level inputs are needed, or use the HELIX Easy Plug Cable and vehicle specific adapter harness (both sold separately, see explanation above). Note: The included speaker level input harness doesn't use the standard aftermarket color codes, and there's no color key in the manual (although the pin positions are labeled on the side of the amp). The colors used are: Black: channel 1 negative Yellow: channel 1 positive Gray: channel 2 negative Red: channel 2 positive White: channel 3 negative Blue: channel 3 positive Green: channel 4 negative Orange: channel 4 positive Line Output: Stereo RCA output jacks make adding another amplifier easy. The settings on the built-in crossovers have no effect on the line outputs. Fuse: The amp is protected by two 25-amp ATO-type fuses. Review this product Submit a review and then enter to win a $500 rewards card Helix Blue B FOUR Reviews Average Customer Review: 3 people say: Review this product: Thanks for taking the time to share your experiences about this product. Please be sure to focus your comments on the product itself. Read our Review Guidelines for more information. Review title * Email Your email won't be visible. Please use the email address that is associated with your order. Display name (e.g., JohnD) Your review will be signed using the display name and location * Your location (e.g., Charlottesville, VA) * Your rating Click on a star to rate the overall product on a scale of 1-5 1500 characters left * Your review Attach a YouTube Review Crutchfield Video Review Guidelines Only submit videos that you made or are authorized to use. Do not submit videos that contain music, video or visuals that are copyrighted and belong to someone else. Please see our Review Guidelines for more information. Submit the URL of your YouTube™ video review or product demonstration. e.g., "http://www.youtube.com/v/o79TWHh598U" 500 characters left Pros 500 characters left Cons * Agree to Terms By checking this box you agree your review becomes the property of Crutchfield, that you are over 18 years of age, that you own or have owned this product, and that you are located within the United States or its territories. Please see our Review Guidelines for more information. We reserve the right (but are not obligated to) review all submissions and edit or remove any review in any manner which we deem necessary. Your review should be posted within seven days. Filter by rating: 5 Star: (0) 4 Star: (0) 3 Star: (0) 2 Star: (0) 1 Star: (0) 5 out of 5 Love it. Written By Bullitt, Houston, TX on Sunday, April 06, 2014 Crutchfield Customer Review (What's this?) Amp seems to be a great valve. Excellent performance for a medium priced amp. Output seem to be better than the rated wattage. VERY clean. You are also able to do a band-pass crossover - High Pass crossover combination which allows me to bi-amp my component speakers without a crossover. No other amp in this price range can do this. Pros: Great sound, Great flexibility due to better than average feature set. Better sound than my JL Audio Slash series amp I replaced. Cons: It wasn't free. 2 out of 2 people found this helpful Was this review helpful? Yes | No 5 out of 5 Solid amp all the way through Written By Nate, Leesport, PA on Friday, June 14, 2013 Got this amplifier for a good price somewhere, but anyway this amp is an extremely solid aluminum frame with heatsink fins that go out 1/4" to 3/8" and offer better cooling than other amps of equal power handling I am currently running 2.7 ohm polk mobile monitor 5x7's to this on every channel and it barely gets warm, so I'd assume this would stay even mildly warm even on a hot summer day on a 2 ohm load The sound quality is phenomenal but even with hearing it and tuning it by hand sounds good if you can, BUY THIS AMP, it's one of the best of the best for this good price range other than the helix esprit tube amplifier, but that runs double useful features: the active crossovers are amazing and allow for an assortment of functionality to this amp whether you plan on running tweeters, mid range or subs on this amp it'll do it to its best for tweeters it can cut off up to 4khz of signal to give the passive crossovers on back of speaker less work for dedicated mid drivers, you can turn on the low pass filter and and cut off the highs up to your desired frequency and the high pass will remain on to cut off the extreme lows as a band-pass filter and allow your midrange to only the intended range for subs, it can do the same with the low and high pass and the high pass will protect your subs from overexerting when in a ported box as you could put it down to 15-25 hz and cut off the low lows and each channel has a 0-18 db 45 hz bass-boost for each channel Pros: Through hole terminals go at an angle to grip the wire better than average amps, solid cooling Cons: A bit hard to get screws through mounting holes because of aluminum fins, but cutting the fins would ruin the aesthetics of the amp 3 out of 3 people found this helpful Was this review helpful? Yes | No 5 out of 5 Helix blue B4--awesome amp Written By JJ, New Jersey on Thursday, November 15, 2012 Crutchfield Customer Review (What's this?) Great amp! It really is very quiet -- I get no alternator noise through this amp at all. I love the fact that this amp is German made and engineered. 6 out of 7 people found this helpful Was this review helpful? Yes | No Add accessories for the Helix Blue B FOUR Add Accessories Add a Warranty You'll need an amp wiring kit to install your new amplifier, as wiring is not included. See all categories & accessories You'll need an amp wiring kit to install your new amplifier, as wiring is not included. Single-amp Wiring Kits Bring the music from your amp to your speakers. Speaker Wire Patch cables take the music from your stereo to the amplifier. Most amp wiring kits don't include them. RCA Patch Cables & Adapters For multi-amp systems, you'll need a separate fuse holder. Fuse Holders Integrate this amp into your factory system Factory System Upgrades Helps protect your car's charging system and improves power handling. Required power and ground wires not included with cap. Capacitors The right tools will make the installation easier. Tools Connectors Other Car Stereo Accessories Rockford Fosgate RFK8i 8-gauge amplifier power and signal wiring kit 30 people say Your Price: $74.99 Add to Cart T-Spec 8PK Installation Kit 8-gauge amplifier wiring kit includes speaker wire 6 people say Your Price: $59.99 Add to Cart Kicker PK8 8-gauge amplifier power wiring kit 1 person says Your Price: $79.99 Add to Cart Rockford Fosgate RFK8 8-gauge amplifier power wiring kit 6 people say Your Price: $64.99 Add to Cart EFX PA8BX Wiring Kit 8-gauge amplifier wiring kit — includes 2-channel patch cable Your Price: $49.99 Add to Cart T-Spec 16-gauge Speaker Wire Black/white jacket priced per foot 13 people say Your Price: $0.69 Add to Cart T-Spec 12-gauge Speaker Wire Black/white jacket priced per foot 29 people say Your Price: $1.99 Add to Cart Stinger PRO Series Speaker Wire Priced per foot (16 Gauge) Options 16 Gauge-$0.39 14 Gauge-$0.65 Priced per foot (16 Gauge) Priced per foot (14 Gauge) 50 people say Your Price: $0.39 Add to Cart T-Spec 2-Channel RCA Patch Cables Available in 7 different lengths (20-foot) Options 1.5-foot-$9.99 3-foot-$10.99 6-foot-$12.99 10-foot-$14.99 14-foot-$17.99 17-foot-$19.99 20-foot-$20.99 Available in 7 different lengths (1.5-foot) Available in 7 different lengths (3-foot) Available in 7 different lengths (6-foot) Available in 7 different lengths (10-foot) Available in 7 different lengths (14-foot) Available in 7 different lengths (17-foot) Available in 7 different lengths (20-foot) 25 people say Your Price: $20.99 Add to Cart T-Spec 4-Channel RCA Patch Cable 17-foot length 7 people say Your Price: $29.99 Add to Cart EFX 17-foot RCA Patch Cable 54 people say Your Price: $7.99After $2.00 Outlet Savings Add to Cart EFX CFHG4 Fuse Holder In-line AGU fuse holder accepts 4- to 8-gauge wire Your Price: $9.99 Add to Cart Rockford Fosgate RFFAGU Fuse Holder Platinum-plated AGU fuse holder Fits 4- or 8-gauge cable 25 people say Your Price: $10.99 Add to Cart Helix EPC5 Easy Plug Cable 5-meter factory system interface cable works with a Helix vehicle-specific harness 2 people say Your Price: $59.99 Add to Cart T-Spec Capacitor 1.5-farad capacitor with red LCD meter 11 people say Your Price: $79.99 Add to Cart Bojo Trim Panel Tools Set of 6 pry tools helps remove interior and exterior trim and door panels 52 people say Your Price: $24.99 Add to Cart Pro.Fit Wire Worm Installation tool helps route wiring through tight spaces 31 people say Your Price: $12.99 Add to Cart Metra Crimp Tool and Connectors Package contains crimp tool and over 150 pieces 15 people say Your Price: $19.99 Add to Cart S&G Wire Cutter/Stripper Tool Cuts and strips 12- to 22-gauge wire 15 people say Your Price: $19.99 Add to Cart S&G Tool Aid 87650 Door Trim and Panel Removal Tool 68 people say Your Price: $9.99 Add to Cart Skewdriver Pro SPK4042 Ratcheting straight and offset screwdriver set with 40 bits (Skewdriver Pro with ratchet handle, pictured) 8 people say Your Price: $49.99 Add to Cart Bojo Trim Panel Tools Set of 6 pry tools helps remove interior and exterior trim and door panels 2 people say Your Price: $29.99 Add to Cart DEI Heat Shrink Tubing Black 4-foot length (Assortment) 6 people say Your Price: $24.99 Add to Cart Autosound 2000 Disc Two Image/Placement Test CD Your Price: $19.99 Add to Cart Autosound 2000 Disc Five System Demonstration Test CD Your Price: $9.99 Add to Cart Autosound 2000 Disc One Low Frequency Test CD (Disc One) 1 person says Your Price: $19.99 Add to Cart Why choose SquareTrade? The #1-Rated Protection Plan Thousands of people have reviewed SquareTrade Protection Plans — and made us #1. 5-Day Service Guarantee & Free Shipping We'll repair or replace your item in five business days or less after we've received it, or your plan is free. And, as always, we pay for all shipping. Protection from Normal, Everyday Use Repairing your average mechanical or electrical failure can cost as much as buying a new device. With SquareTrade, you're covered — including parts and labor. 3 Year Protection Plan Your Price: $49.99 Add to Cart For a more in-depth review and enhanced detailed information on the Helix Blue B FOUR, please visit the Crutchfield website product page (/ISEO-rccbcspd/p_975BFOUR/Helix-Blue-B-FOUR.html ). × Front Left Right


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- Antique Jewelry
- The Ages
- Engagement Rings
- Antique Rings
- Diamond Jewelry
- So Much More
Forever - Antique Engagement Ring G Color
New lower price!!! Down from $13,250! This is the ring which simple says "forever" that is on the dream list of every woman. Start with a sheer wonder of a diamond of over a carat at 1.02. Add a snowy white old European brilliant cut diamond of G color and a very fine clarity of VS1 and the ring rises to near perfection. Top that off with a classic sinuous platinum mount which features swags and tiny bows, open work and accent diamonds and you have The Three Graces top pick in engagement rings.
Moreover, sixteen (16) single cut diamonds dot the ornate mille grain surface for an additional total estimated diamond weight of .16 carats. Embraced in platinum, the prongs of the central diamond ensure minimum wear exposure over time. Elegant in its lines, graceful and artful, no one can resist this ring which in 30 years will still be in style. A wedding band is easily worn with this ring if desired. This is not to be missed!
Date: Circa 1910.
Accompanied by a Gemological Institute of America (GIA) certificate for the main diamond.
Measurements: 5/16 of an inch (0.9 cm) in length north to south on the hand and rises 1/4 of an inch (0.8 cm) in height off the finger. Weight of 3.0 grams (1.9 dwt).
Ring Size: US 6-3/4 (UK N; Euro or Int. Circum. 53.8 mm; Int. Dia. 17.1 mm; Japan over 13) and easily can be sized to fit most. Ring sizing information.
Hallmarks: Partially worn Irid Plat mark; faint trace of an old engraving to interior, now illegible.
Condition: Excellent.
Origin: American.
Note 1: This ring comes with a Gemological Institute of America (GIA) certificate for the main diamond which has been removed from the mount for accurate weight and grading.
Note 2: The main diamond has been accurately weighed and graded. The weight of the other diamonds has been approximated by measurement and formula and may vary from actual weights.
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This paper, in an effort to help authors make informed choices about their rights, compares and contrasts how the agreements of 12 publishers permit authors to meet the requirements of the NIH Public Access Policy and share their works while they are under embargo.
Sitting en banc, the U.S. Court of Appeals for the Eleventh Circuit on June 30, 2008, decided Greenberg v. National Geographic Society, finding that the CD-ROM set, "The Complete National Geographic" (CNG), was a privileged revision of a collective work under 17 U.S.C. § 201(c) and not a "new collective work" in violation of Mr. Greenberg's copyrights. This case is in line with the Second Circuit's decision in Faulkner v. National Geographic Enters., further clarified the U.S. Supreme Court's ruling in New York Times Co. v. Tasini, and importantly, upheld the "long embraced doctrine of media neutrality" that the "transfer of a work between media does not alter the character of that work for copyright purposes."
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NIKE Junior & Youth Amped Mouthguards [E65660]