text: Panamax MD2 Space-saving surge protector with two outlets Zoom Front Cover is removable and paintable Plugged into wall socket Side Photos Videos Item #: 299MD2 Review Summary 8 people say In Stock Free Crutchfield lifetime tech support Free Shipping Your price $39.99 Add to cart + Add to wishlist Email me alerts for this product Buy this item and earn up to 40 Rewards points See more offers and ways to save Save 10% with select home A/V gear Special Financing Available x By buying this product you'll earn up to 40 Rewards points. When you sign up for a Crutchfield account, you'll be enrolled in Crutchfield Rewards. You'll earn one point for every dollar you spend on gear from us. You can turn your points into Rewards Cards that you can use toward future purchases. You can sign up for an account now, or after you complete your purchase (you'll get credit for the points either way). Sign up for a Crutchfield account Overview Details Customer Reviews Q&A Articles & Videos Our take on the Panamax MD2 by Steve Kindig Don't let a lack of space keep you from protecting your gear with a quality surge suppressor. The compact MD2 plugs right into a standard AC wall outlet, and has two AC outlets placed on the sides to allow space-saving connections. You can plug in a TV and Blu-ray player and keep your furniture close to the wall, or protect a couple small appliances on your kitchen counter. The MD2 is also a smart choice to use with chargers for your cell phone or portable player. Panamax's dependable noise filtering ensures that your equipment gets only clean power. See more info on this item Our 60-day money-back guaranteeHighlights:2 side-mounted AC power outlets (always on)Protect or Disconnect circuitry safeguards equipment against all surges (disconnects AC power in the event of a lightning strike or other "catastrophic" surge)EMI/RFI noise filtering provides clean powermaximum current rating: 15Aremovable, paintable cover3-3/8"W x 5-3/8"H x1-5/8"Dlifetime $100,000 connected equipment warrantylifetime product warranty Hands-on research from the Crutchfield Labs (what are the Labs?) Features and specs chart | What's in the box? | In-depth notes Features and Specs Type On-wall Total AC Outlets 2 High-Current Outlets None USB Connections None RF-EMI Filtering Yes Joule Rating 1350 Powerline Network Compatible No Connected Equipment Guarantee $100,000 Width (inches) 3-3/8 Height (inches) 5-3/8 Depth (inches) 2-7/16 Weight (pounds) 0.65 Parts Warranty Lifetime Labor Warranty Lifetime Product Research What's in the box? Download owner's manual Two AC outlet surge protector Removable/paintable front-panel (installed) Machine screw Installation Instructions Our Product Research Team At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team — they open the box, verify contents, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices. Features Specifications Warranty Features Protect or Disconnect Circuitry: The Panamax MD2 Surge Protector's exclusive "Protect or Disconnect" circuitry safeguards your equipment against all surges. In the event of a catastrophic surge such as lightning, the MD2 completely disconnects AC power to your connected equipment. Two AC Outlets: The two 3-prong AC outlets are turned 90-degress from one another to accommodate different style plugs or transformers. One plug is located on the left-side, while the other plug is located on the right-side. Right-Angle AC Plug: The Panamax MD2 Surge Protector features an integrated right-angle 3-prong AC plug which plugs directly into an AC wall outlet. Noise Filtration Circuit: The Panamax MD2 Surge Protector utilizes a Noise Filtration Circuit (EMI/RFI) to remove noise and provide clean power. Two Diagnostic Lights: Two Panamax MD2 is equipped with two Diagnostic Lights (LED) - Power On/Protection OK and Line Fault. Power On/Protection OK: This LED (blue) indicates the power is on, surge protector is functioning properly, and all connected equipment is protected. Line Fault: If this LED is lit (red), it indicates an improperly wired outlet. Paintable Cover: The MD2's removable front-cover is paintable to ensure a seamless fit with almost any décor. Specifications AC Power: Protection Modes: L-N, L-G, N-G UL 1449 Rating: 330V Voltage Protection Rating: L-N 400V, L-G 500V, N-G 400V Single Pulse Energy Dissipation: 1350 Joules Response Time: <1 ns Peak Impulse Current: 60,000 A Nominal Discharge Current: 3,000 A Maximum Current Rating: 15A (1800 W) Line Voltage: 120 VAC, 50/60 Hz Initial Clamping: 200V EMI/RFI Noise Filtration: 50 dB (100kHz - 1MHz) Warranty $100,000 Limited Connected Equipment Protection Warranty: Panamax will replace or repair equipment that is damaged by an AC line surge while connected to a properly installed Panamax surge protector (up to $100,000). Lifetime Product Warranty: The surge protector shall be free of any defects in design, materials, or workmanship; and Panamax will repair or replace any defective unit. Review this product Submit a review and then enter to win a $500 rewards card Panamax MD2 Reviews Average Customer Review: 8 people say: Review this product: Thanks for taking the time to share your experiences about this product. Please be sure to focus your comments on the product itself. Read our Review Guidelines for more information. Review title * Email Your email won't be visible. Please use the email address that is associated with your order. Display name (e.g., JohnD) Your review will be signed using the display name and location * Your location (e.g., Charlottesville, VA) * Your rating Click on a star to rate the overall product on a scale of 1-5 1500 characters left * Your review Attach a YouTube Review Crutchfield Video Review Guidelines Only submit videos that you made or are authorized to use. Do not submit videos that contain music, video or visuals that are copyrighted and belong to someone else. Please see our Review Guidelines for more information. Submit the URL of your YouTube™ video review or product demonstration. e.g., "http://www.youtube.com/v/o79TWHh598U" 500 characters left Pros 500 characters left Cons * Agree to Terms By checking this box you agree your review becomes the property of Crutchfield, that you are over 18 years of age, that you own or have owned this product, and that you are located within the United States or its territories. Please see our Review Guidelines for more information. We reserve the right (but are not obligated to) review all submissions and edit or remove any review in any manner which we deem necessary. Your review should be posted within seven days. Filter by rating: 5 Star: (0) 4 Star: (0) 3 Star: (0) 2 Star: (0) 1 Star: (0) 5 out of 5 Simple Solution! Written By KW, Austin, TX on Tuesday, September 09, 2014 Crutchfield Customer Review (What's this?) I only needed 1-2 oulets for under my desk, and this is the perfect fit. I've owned Panamax products for many years and have experienced many lightning storms and power fluctuations, and never had a single issue with anything (so I guess they are working as they should). Didn't even look at any other brands - I trust Panamax. Pros: Perfect Size Cons: None Was this review helpful? Yes | No 5 out of 5 Perfect fit! Written By josh, Fredericksburg, VA on Monday, May 26, 2014 Crutchfield Customer Review (What's this?) This item fits perfectly between the supports of my Sanus LT25-B1 wall mount and behind my 70" Vizio. Initially, I wanted to use a Panamax In-wall surge protector but my house wiring made it difficult, so I settled on this product. I was relieved when it fit perfectly behind the tv. Green function light is a nice touch. Pros: Great size, nice green running light. Cons: None so far. Was this review helpful? Yes | No 5 out of 5 Quick Easy Peotection Written By t, Indianapolis, IN on Monday, March 31, 2014 Crutchfield Customer Review (What's this?) Quick Easy Power protection. Purchased this to protect my Receiver and components in the Garage. Next day we had a power surge and all was well! Great Item Pros: Small, side plugs and bang for the buck! Cons: None Was this review helpful? Yes | No 4 out of 5 Panamax MD2 Written By RobN, Orlando, Fl. on Friday, January 31, 2014 Crutchfield Customer Review (What's this?) Works great for my application. limited room. Fit behind console and able to slide console tight to the wall Pros: Size Was this review helpful? Yes | No 4 out of 5 WOrks Written By Jason, Fort Worth, TX on Saturday, July 20, 2013 Crutchfield Customer Review (What's this?) Works as advertised. It's a nice low profile unit that holds itself into the outlet. You can remove and paint the outside over - which is a nice feature - but it would be really nice if they offered it in black. (like most theater room ceilings are painted) Pros: Works as advertized. Cons: Wish it came in black. (without having to paint) Was this review helpful? Yes | No 4 out of 5 Works as advertised Written By PR, Hummelstown, PA on Monday, October 08, 2012 Crutchfield Customer Review (What's this?) The weight of the surge protector makes it at least seem as if you are paying for some protective circuitry. Slim profile fits well against the wall behind a book case with side mounted outlets allowing cords to come out through the sides. Having never had issues with surges in the past, I can't say if the pricey cost of this for only two protected outlets is justified. It would be nice if the unit had 4 outlets, which it looks like there's space for. Pros: Good sleek profile fits along walls well and behind furniture. Cons: Only two outlets, price. 1 out of 2 people found this helpful Was this review helpful? Yes | No 5 out of 5 GREAT SURGE PROTECTOR Written By Ron, Jacksonville, NC on Friday, February 18, 2011 Crutchfield Customer Review (What's this?) Super surge protector, compact, two outlet, does it's job in a stellar manner! Must Have! 1 out of 1 people found this helpful Was this review helpful? Yes | No 5 out of 5 Panamax is a MUST to protect your equipment Written By BecsFL, Florida on Thursday, October 28, 2010 Crutchfield Customer Review (What's this?) I purchased quite a few of these individual outlet surge suppressors for equipment. I am very happy with the Panamax brand and can feel safe and comfortable knowing that these suppressors will do their job in protecting my equipment. I learned the hard way by losing over $5,000 worth of equipment due to severe lightning strikes. The equipment I lost was all the equipment I never had surge suppressors on, so take my loss as a lesson, and get protected, ESPECIALLY if you life in Florida... the lightning capital of the world. I am also very happy with the service I received from Crutchfield. HIGHLY recommended. 4 out of 4 people found this helpful Was this review helpful? Yes | No For a more in-depth review and enhanced detailed information on the Panamax MD2, please visit the Crutchfield website product page (/ISEO-rccbcspd/p_299MD2/Panamax-MD2.html ). × Front Cover is removable and paintable Plugged into wall socket Side Searches related to the Panamax MD2 Space-saving surge protector with two outlets Panamax Panamax Power Protection Power Protection under $50 Panamax MD2 reviews Panamax MD2 vs Monster Core Power® 650 USB Panamax MD2 vs Panamax SP8-AV Panamax MD2 vs Monster Core Power® 600 AVU Panamax MD2 vs Sanus SA206 EcoSystem™ Mini


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INGLEWOOD, Calif. (March 8, 2010) — Hollywood Park, in an effort to protect overnight purses, has responded to the declining economy by shuffling its stakes calendar for the 60-day Spring/Summer Meet, which opens Wednesday, April 21.
The $5.8-million stakes schedule, which includes seven Grade I races and 28 graded races overall, is highlighted by the 71st running of the $500,000, Grade I Hollywood Gold Cup on Saturday, July 10. The $250,000 Triple Bend Handicap (GI) will also be run on that day.
The Jim Murray Memorial Handicap and the Will Rogers Handicap will return to the calendar, while the Ack Ack, Cinema, Gallant Man, Flawlessly, Khaled and Round Table will placed in hiatus for 2010.
"We've made these changes in an effort to keep overnight purses as high as possible as we cope with the struggling economy," said Martin Panza, vice president-racing. "We've got to put as much money in overnight purses as possible to aid horsemen in these tough economic times."
The ninth running of the $250,000, Grade I American Oaks is scheduled for Saturday, July 3, along with the $150,000 Royal Heroine Mile (GII). There will be five stakes contested over the Fourth of July weekend with the $150,000 American Handicap (GII) scheduled for July 4 and the $100,000 Hollywood Juvenile Championship (GIII) for a special Monday program on July 5.
The Hollywood Gold Cup and American Oaks programs are among seven multiple stakes days at the meeting, beginning with Gold Rush XI on Saturday, April 24. The $200,000 Snow Chief Stakes is the feature race, but has significant company in the $150,000 Melair, $125,000 B. Thoughtful and $125,000 Tiznow.
The $250,000-added, Grade I Shoemaker Mile will be run on Memorial Day — Monday, May 31 — along with the Honeymoon Handicap (GIII) and the $60,000-added Willard L. Proctor Memorial Stakes. The Shoemaker, first run as the Premiere Handicap on Hollywood Park's inaugural opening day on June 10, 1938, will be contested for the 66th time.
In keeping with recent tradition, the prestigious $250,000 Charles Whittingham Memorial Handicap will be run on Saturday, June 5 — Belmont Day. The Grade I event will be accompanied by the $100,000 Los Angeles Handicap (GIII) and the $60,000-added Redondo Beach Stakes.
The $150,000 Californian (GII), last major stepping-stone to the Hollywood Gold Cup, will be run on Saturday, June 12, along with the $60,000-added Desert Stormer Handicap.
Closing weekend will feature the $200,000 Swaps Stakes (GII) and $150,000 A Gleam Handicap (GII) on Saturday, July 17, with the $100,000 Sunset Handicap (GIII) on Sunday, July 18.
The $150,000 Milady Handicap (GII) and the $250,000 Vanity Handicap (GI), races two-time champion Zenyatta swept the past two years, will be contested on Sunday, May 16, and Sunday, June, 13, respectively.
The stakes schedule begins with the $60,000-added Harry Henson Stakes on April 21.
View the complete stakes schedule
Copyright © 2009-2014, Hollywood Park. All rights reserved.

subset: commoncrawl


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You could prepare for cooler weather by stuffing your face with epic amounts of seasonal treats and rich foods — or you could go a healthier, more stylish route by donning the Monterey button-up by Billabong. This long sleeve shirt has a lightweight cotton construction and features a military-inspired Billabong logo pin on the pocket, a woven brand label at the back yoke and a contrast color button-in hood for windy days. Basically, it's comfortable, functional and pretty darn dashing.
- 100% Cotton fabric
- Billabong lightweight button-up shirt
- Billabong logo pin
- Button-in hood with drawstring
- Imported
- Rounded hem
- Single button at cuffs
- Two chest pockets with button closures
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I ordered this comforter set for my daughter. The image shown appears to be a colored background comforter set with a white and lime green print. What I receieved was a white background with coral and lime green print. Very dull looking!
We bought the full and twin size sets for our girls bunk beds and we absolutely LOVE them! The girls were pleasantly surprised as well and the quality of the comforter stands up to its price. The only thing I wish was different was if it came with sheets!
Bought this for my daughter's dorm and it is nice. The pink is more of a coral color though and the green in not a 'lime" as it appears in photo.
The set itself is really nice. However the colors are off. It's not hot pink as depicted in the picture, but rather and shade of peach. Still nice, but not what I was expecting.
The picture is of a Pink and Green - But, the decription states Coral. Very mis-leading.
Not exactly the color that it looked like in the pictures, but satisfactory.
The colors were not what they looked like online. It looked pink but was coral. It didn't match my room, but otherwise found no fault in it.
I purchased 2 of these for my girls who are now sharing a room. It is a nice quality, the color is more coral than pink, which we loved! Ours are more of a white comforter with coral & lime green accents. Perfect because we painted the room coral , so it needed to be toned down!
I kept this BUT not exactly what I pictured. It really is a orange coral color. More so than I thought. Also not very large. I will need a dust ruffle I think. It is very soft fabric. Not quilted or tacked down at any point so tends to shift some and not lie really flat. But it works. For the price.
The pattern is pretty and fabric is soft. I didn't keep it long enough to test washability. I was disapointed in the colors. The pink is definately more of a coral. The lime has a lot of yellow in it and not as green as portrayed. We are returning mostly because the color palate didn't match we wanted. But if you are looking for a nice coral pink and lemon lime green combo, its is a pretty pattern and brightens up a room
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** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.


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A 14K yellow-gold ring set with one semi-round South Seas Pearl, 13-14mm and golden in color, and eight faceted round Diamonds totaling 0.05 carats, total weight. Approximate width of setting = 9mm or 3/8"
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You don't have to be a pink bunny that's wearing sunglasses and beating a drum to be able to go on and on. You don't stop moving from the minute you wake up till you fall asleep at night, and you wouldn't trade your busy lifestyle for anything. Look way cooler than that fluffy rabbit in the Energizer tee from Rip Curl. It features Rip Curl lettering printed across the chest in a contrast color scheme. It's simple style that doesn't get in the way of what you need to do so you can just keep going... and going... and going...
- 100% Cotton fabric
- Imported
- Regular fit T-shirt
- Screen print graphics
- Tagless collar
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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Letters to the editor - Tuesday (3-26-2013)
Church & state: Our forefathers understood the difference
Church and state are not the same. They constitute different realms.
However, both are part of God's order for humankind. The founding fathers seemed to understand that.
God ordained both; one reflects our relationship to God, which is ordered by love, while the other reflects our relationship to each other, which is ordered by justice. As citizens, we have the right to expect justice and good governing in the realm of the state, just as we expect to experience redeeming love in the realm of the church.
Although governing is ordained by God, for the sake of good order (safety, protection, freedom and mutual concern), it is not the church. A government does not receive divine credentials other than being a part of God's good order. Justice alone is its concern.
Too bad our county commissioners have difficulty making this distinction.
Their task is to serve the people who elected them in the spirit of "liberty and justice for all." A government has no business imposing sectarian religious practices into the business of governing.
Allow your faith foundation to motivate your work and efforts for good governing. But please don't use it as an imposition for your system and practices through government. Many may share your faith convictions, which are not in question and have great merit. However, that does not make them right or just for all.
— David P. Nelson
Fund fight with private money
While I personally support their endeavor, our commissioners need to consider the possibility that they might be held personally liable in a taxpayer suit for misuse of a substantial amount of public money in fighting the prayer lawsuit in court, since, unfortunately, the current law of the land and precedent seem to be against us. This is not a rich county, but by all means, do what you want to with private money.
— M.B. Blankenship Jr.
An attack on our society
The very structure of our society — including the family, the civil government, our laws, values and principles — were founded in our Christian Holy Bible. The framers, who for the most part were Christian, made a covenant with our creator in heaven, and he blessed us. Now, with the endless flow of money to support the ACLU and its hatreds and prejudices, it and other organizations in good company with the social-liberalists are working overtime to violate our freedoms of speech and religion and what is left of our liberties. Yet, do you see these vipers attacking those of other religions or atheists? It's open season on Christians and conservatives. All we can do is pray for our enemies and "stand our ground."
— John T. Nall
Hatch a plan for mall
In a recent Salisbury Post article, Economic Development Commission Executive Director Robert Van Geons said he was looking for a business incubator.
We are looking and hoping you can "hatch" something in the incubator for the Salisbury Mall. Some good stores are still there, and some good people are there, too, with plenty of parking space, also. Just one example, among others: K&W Cafeteria.
— Graham Foster
Thanks for supporting benefit
Faith Farm & Equipment would like to give thanks for the outpouring of love shown at the recent benefit held at our store for Jeff and Jennifer Price. Despite the slow economy, Rowan residents opened their hearts to ease the burden of friends in need.
We had the support of many friends, along with church members from Faith Baptist and Lyerly Evangelical, who assisted cooks Lanny and Linda Merrell and Barry and Lisa McDonald. Businesses contributing to this event were Cheerwine, College Barbecue, Faith Soda Shop, M&K Barbecue, Wink's Barbecue & Seafood, Barry McDonald Refrigeration, Corbin Hills Golf Club and OED/Shindaiwa.
A special thanks to our store manager, Richard Peeler, who recognized this need, brought it to fruition and helped bring everyone together. Thank you, Rowan County, for the continued support of our business.
— Tim & Pam Ervin


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Benally Baldenegro is an attorney who told us she's been working with non-profit organizations on creating financial education programs for the past few years. This work has helped her to see the needs of this community and also realize the great need for leadership in the area that encompasses the district. She told us that voters in the district, as it's currently being drawn, are made up of about 21% Native Americans and 18% Latinos, something she says is important because "we've never had a voice from Arizona represent our communities."
But, she said there were two principal reasons she decided to run for Congress. One, the seat is currently held by a Republican, Paul Gosar, who defeated Democratic incumbent Ann Kirkpatrick in 2010 because, as Benally Baldenegro tells it, she tried to move towards the middle, something many Democratic voters did not appreciate, Demonstrating their discontent by not showing up to the polls in 2008. If a Democrat is to win the seat, she told us, they must stick to their "Democratic values," such as not supporting policies like SB 1070 or the states war against ethnic studies.
Aside from that however, Benally Baldenegro says her decision to run for Congress is much more personal. "This is where I'm from, this is where I was raised my entire life. I've always wanted to come back here. I'm Navajo so I grew up on a Navajo reservation, which is in the district," she said. While some may say that politicians in Arizona need soften positions on immigration or ethnic studies, Benally Baldenegro says the focus should be on jobs and the economy, especially during a time when, "a lot of folks are out of work." Jobs were definitely a top issue for Benally Baldenegro, which is why she said that having a voice on the federal level would be in port for the people in her district.
When it comes to the Native Americans district, Benally Baldenegro told NewsTaco that this community's direct relationship with the government is distinct and unlike the type of relationship most people in the U.S. experience. For this reason, she feels that her presence in Congress would allow her to more effectively advocate for this community, especially when it comes to the values she feels are integral to them, such as equal opportunity, and liberty.
Benally Baldenegro is running a self-described "grassroots campaign" in which she's adopting an Obama type strategy when it comes to fundraising, blockwalking, meeting and greeting, and dedicated to not taking corporate money. She says it's working, noting that it's only December and she has about 50 volunteers ready to help her campaign; she also recently received the endorsement of the United Steelworkers, the largest union in the district.
Link to original article from News Taco


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Yes - I must plan ahead. The first couple days were easy because I made brown rice, the curry soup, bean paste etc. Tonight I plan to make some new staples to keep on hand. The baked chick peas sound really good as a snack.
I have a work luncheon today and called yesterday to request a vegan meal. They were very accommodating and now I can't wait to see what I get to have for lunch!
Unfortunately, I dropped my car off at the repair shop this morning and just got a call that I need a $1,200 repair. GULP! Oddly enough, no urge for chocolate whatsoever! Hooray!
Determined wrote:
The in-a-hurry times are when you need a base (bread, roll, tortilla, etc) and a topping (like hummus and pre-sliced veggies) or nut butter and good jam - nothing like that old go to sandwich for simple on the go meals (and readily vegan - who would ever really stop to think that good old PBJ is basically vegan!)
And, too, since this is a lifestyle change, not just a 3 week "diet plan", things do get easier over time. Learning to prepare dry beans was one of the harder things for us but now it's just routine to look at what we've got planned for the week (we write out a two week menu plan so I can efficiently do the grocery shopping - not etched in stone, things can shift days, but we know we've got the ingredients and can gauge prep time in advance and work out the schedule) and know which nights we need to put beans to soak before going to bed. Then hubby pulls out the pressure cooker first thing and starts that (cooking the beans) while he has his oatmeal for breakfast (pressure cooker/canner was one of our best investments!). They get popped into containers and refrigerated and we've got that ready before lunch even! (if he's cooking chickpeas, one portion of the still hot beans becomes hummus while the rest get stored for later use) We've always been "leftover eaters" so making extra for lunches was no big deal - and we generally plan a 'leftover day' for Saturday or Sunday (depending on our schedules) where we just eat up whatever is still in the fridge from the week to make space for the next round of meals/leftovers (Sundays are often pretty busy days for us so being able to just heat and eat is good)--Deb R
Welcome aboard Cuteddybears! We're glad you're here!
I am amazed that after only 3 days my sweet tooth is starting to subside. I know when I did atkins several years ago, after a week, I had no desire for sugar - so hopefully the same will be true for all of us - with sugar and cheese!
Stay strong girls! We can do this! kay
Honningmelon wrote:
Yaaay! GO KICKSTART!
Happy thoughts from Nora in Norway
Welcome! Being of Norwegian descent, I was extremely lucky to be able to travel there a number of years ago and see where my family came from (Sognenfjorden) and travel from Oslo all the way to Bodo and the Lofoten Islands. Fantastic country! Although an omnivore at the time, I was always afraid of the food since I'm allergic to fish. Good luck!
Come visit me at:http://vegpedlr.net
Happy Day 4...although it is almost over. I am discovering that my appetite has lessened and that I go longer between meals before wanting food. I really had doubts that that would ever happen! Sweets have for years been my downfall. Lately, salty foods like crackers were my undoing.
At the supermarket today, I took time to read carefully all of the ingredient lists on anything I was buying. It's amazing the hidden animal products!
Eventually, my system will even get used to all the extra fiber, but for now, I'm pacing myself and adding it a bit at a time.
Have a great Day 5! We can do this!
Welcome, cuteteddybears and Nora and anyone else I may have missed!
[quote="WalksWithDogs"] I am discovering that my appetite has lessened and that I go longer between meals before wanting food. I really had doubts that that would ever happen! [quote]
You go, girl! I am stunned how much less I am thinking about food too. And how much more productive I am. I wish I could understand why I am feeling so positive and strong - I can't tell you how many times I've fallen off the wagon before the end of the first day. But I just know that this is my new lifestyle - it feels so right.
I think the difference is that there are SO MANY great reasons to eat a plant based diet. Making my diet about something larger than myself has really made me stronger. I hope it's making you all stronger too. This forum has also made a difference. It's just great to think about all of you when I'm having a weak moment.
I hope everyone has a great evening and an even better DAY 5! I'm off to make some roasted chick peas and chili Kay
In regards to "cheese" recipes, the latest issue of VegNews has an article on artisan vegan cheeses with recipes for 4 different cheeses to make.
I don't know what the view on vegan cheese is from dieticians (Lani can you help here?) I wonder if they may be seen as high fat and if they just contribute to high fat cravings (Are there such things?) and if it might just be better to be cold turkey off of cheese.
Thanks for the great tips DebR and Kay!Luckily BF eats whatever I cook, so he's happy to eat lots of veggies and he loves beans, so I am very lucky to have him But tonight I'm making pizza! Regular pizza for step-daughter (age 6) and BF (he's craving), and for me... A recipe from my favorite vegan chef Chloe Coscarelli! This, just without all the oils. http://chefchloe.com/entrees/roasted-apple-butternut-squash-and-caramelized-onion-pizza.htmlI haven't tried this before, so I'm quite excited! Her Avocado Pesto Pasta is AMAZING, but it's full of olive oil and (obv) avocado's, so not suitable for our current diet :/ But amazing comfort food for another day and time!
Dear Vegpedlr, that's so awesome! There's actually a TV-show here in Norway, huge success, I watch it every season, that is all about Norwegian-American's coming to Norway, discovering their roots and the winner in the end gets to meet their family in Norway and everything. Kinda reminds me of it! I work with incoming tourism, actually, and we do get quite a few Americans Yeah, vegan food in Norway is tricky! Very slim pickings, only a few health food stores that carry what we need, and if you want a package of soy dogs, it's minimum 50 NOK, which is about $10, and the package has 9 sausages. I think that's quite a bit more than in the US, right? And I've tried getting my hands on some tofu, but I can't find it ANYWHERE. Gonna have to order online.Anyway, Vegpedlr, I see you're at Bay Area? I AM SO JEALOUS!!!! Went to SF once in 2008... It was just AMAZING. One of my favorite holidays, just perfect. I've been wanting to go back ever since!
[quote="Honningmelon"]Luckily BF eats whatever I cook, so he's happy to eat lots of veggies and he loves beans, so I am very lucky to have him [quote]
I'm glad that you are appreciating your BF. My hubby is a strict meat is the entree man - he won't even eat leftovers - which kills me. Gratefully, he has taken my son out for dinner a couple of nights while I stay home and do my own thing. I miss having dinner with them, but am glad not to be cooking or tempted by things I can't have.
[quote="Honningmelon"] A recipe from my favorite vegan chef Chloe Coscarelli! This, just without all the oils. http://chefchloe.com/entrees/roasted-apple-butternut-squash-and-caramelized-onion-pizza.html[quote]
Oh my gosh, that pizza sounds AMAZING! How was it? If you give it the thumbs up, I will definitely be making that this weekend!
I'm a bit nervous because I have a cocktail reception this evening - and then drinks and a dinner party on Saturday. I hate to admit that I read the Kickstart book a long time ago -and have not picked it up again. Is even one glass of wine allowed? Since I haven't seen it on any of the menus, I'm going to err on the side of caution and stick with water or club soda
I'm very motivated. Down 5 pounds this morning! I know this pound-a-day rate of loss won't continue - but I've only worked in exercise one day this week - so I'm thrilled with the results. I'm hoping to get more execise in over the weekend.
Wishing you all a great Friday. Kay
Guess it's early morning-time in the US now? I'm still at work, it's only half past one in the afternoon. So making pizza later tonight! I will defo let you know! I am quite excited
I read the book recently, and what he says is that it's not forbidden. It says in the FAQ-section (I happen to have the book with me here at work!) that it's not restricted, but they limit it to one drink per day for women (two for men). Obv the healthiest thing is just not drinking anything! But it's not forbidden
Thank you, Nora. I may save one glass for tomorow evening at friend's birthday dinner. It makes me happy just to know that I am allowed one occassionally!
Yes, early morning here. Just getting ready to start a very long day. Glad yours is more than half-way through! I can't wait to hear your review of that pizza - and thank you for turning me onto the chef! Kay
Hello again!
So I made the vegan pizza! Well, not exactly... I couldn't find butternut squash (another rarity here in Norway), so I just piled on mushrooms, spinach, onion, courgette, corn, and soy dogs. I used my usual recipe for pizza dough which is basically just flour, yeast, water and a spoon of olive oil (it's Friday!), but I did use Chloe's recipe for white bean hummus, or purè, or whatever she called it. So I put the white bean thing on the dough, then some tomato sauce (plain with a bit of basil) and then veggies. Quite tasty!! I didn't feel deprived at all. The cheesy pizza looked tempting, but I stayed away. Very filling and good. Recommended as a DIY! See pics pre-cooking here https://twitter.com/honningmelon/status/244109647768846336/photo/1 and post-cooking here https://twitter.com/honningmelon/status/244124116163117057/photo/1.Yummers!At work now, "working" the night (read: get paid to sleep). Have a still wonderful Friday, guys!
Hello everyone! Wow! What a hectic week - glad it is Friday. I've been doing pretty well adn have dropped a couple of pounds! Yay! My problem is snacking in the evening. I found if I have a couple of dried dates stuffed with an almond my sweet craving goes away. As far as yogurt goes, I found a soy one at Fred Myer made by So Delicious that is great. They have several flavors and you can go to their website and get coupons on any of their products. Keep it up everyone. Happy weekend. Pam
Nora your pizza looked awesome. I hope you're sound asleep and getting paid for it - how does that work exactly? Honningmelon wrote:
Great job, Pam. I had an insane week too. Someone told me there was a blue moon over the weekend. I think it probably has more to do with the 4 day workweek. No matter the reason - I think we should be very proud of ourselves for staying on track when we are stressed! Go us!
I was run ragged till 5:30 and then had to go to a 'cocktail attire' event. It's way too hot for cocktail attire when you're 100 pounds overweight. I did break down and have one glass of wine. But ate some grilled veggies and a sliver of what I thought was vegan quesadilla. I think there may have been some cheese on it, but very little.
I actually got into a discussion about my reasons for being vegan - and after some fumbling, I wound up saying "I want to leave a smaller - and shallower - footprint." Sort of sums it all up
My husband doesn't seem to like me much these days - so I'm glad I have this outlet for conversation. Tomorrow we will be going out together with 3 other couples. Hopefully we'll be in a better place by then.
Stay strong - only 16 days (and a healthy lifetime) to go! Kay
Hi All - Hope everyone is having a great Saturday.I love rading everyone's posts and your great - helpful ideas! My 2 cents on the preceding posts.
If I'm going out (like tonite) I will have a wine spritzer - 1/2 a glass of wine with a LaCroix. That way I can usually sneak in two drinks if I'm feeling deprived.Nevertolate - I so agree about how hard it is to find the right the clothes! Going to a 50th b-day party. Have the outfit all set then get an email from the hosts saying its casual and wear comfy shoes its outside! ugh! Not what I was planning on.I definitley need to stay away from nut butters - I think they thrigger more overeating for me.I also stay away from the fake cheeses - can't find one I like that isnt highly processed and low in fat.I did find at Whole Foods a veggie pizza - individual size. Whole Foods brand that had 1 gram of fat. It hit the spot last night.I had a slow start but I am down 3lbs. thus far. Though I was already eating mostly vegan - but cutting out the oil and fat had helped (I hope).Take care
I was feeling like I had abandoned the group since I didn't post yesterday or all day today until now. Hmmmm....so where is everyone whom I abandoned? Are you having a good weekend?
It's been a very difficult weekend for my husband and me. We are having a crisis with my dog, a big Lab, and she is currently in the hospital. I'm tired and worried, but have stayed with vegan except for last night when I had two eggs and a little margarine on my toast. I was so exhausted that I didn't want to think about cooking anything. Choices have not been great, but not terribly bad.
I hope everyone returns quickly. If anyone has had difficulties sticking with the program, just jump back in! We are seeking excellence, not perfection!
I was feeling the same! Feels like I haven't written in ages, and no one else has either.
Kay, it's kind of like a boarding school for teens with hearing impairment. Basically I just check who's there, and if the fire alarm goes off, I need to check it out and get the kids out, in case they don't hear the alarm. Pretty sweet gig, and the fire alarm hasn't gone off on my watch yet (worked there for like 4 years).
I went to my nan's on Saturday, with BF and his daughter. Nan's 89 years this year, and she is sooo fragile. She's got troubles doing basically everything. And when we got there, she had made waffles! Which probably took her all day! And I hadn't seen her in ages, and she'd worked so hard. So I had one piece of waffle. Norwegian waffles aren't like Belgian, one piece of waffle is like the size of half a toast, and it's not very thick either and not fried. But it does have eggs and milk in it. So there. BF ate extra to compensate, bless him!
But beside that I did whole last week vegan.How did you guys do?
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Year of publication
- hepatitis C virus (2)
- Alcoholic liver disease (1)
- Cellular (1)
- Cytoskeletal proteins (1)
- DNA mismatch repair (1)
- Digestive system (1)
- Endoscopy (1)
- Fibrotest (1)
- Medizin (36) (remove)
- Baseline MELD score predicts hepatic decompensation during antiviral therapy in patients with chronic hepatitis C and advanced cirrhosis (2013)
- Background and Aims: In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy with peginterferon and ribavirin is feasible in selected cases only due to potentially life-threatening side effects. However, predictive factors associated with hepatic decompensation during antiviral therapy are poorly defined. Methods: In a retrospective cohort study, 68 patients with HCV-associated liver cirrhosis (mean MELD score 9.18±2.72) were treated with peginterferon and ribavirin. Clinical events indicating hepatic decompensation (onset of ascites, hepatic encephalopathy, upper gastrointestinal bleeding, hospitalization) as well as laboratory data were recorded at baseline and during a follow up period of 72 weeks after initiation of antiviral therapy. To monitor long term sequelae of end stage liver disease an extended follow up for HCC development, transplantation and death was applied (240weeks, ±SD 136weeks). Results: Eighteen patients (26.5%) achieved a sustained virologic response. During the observational period a hepatic decompensation was observed in 36.8%. Patients with hepatic decompensation had higher MELD scores (10.84 vs. 8.23, p<0.001) and higher mean bilirubin levels (26.74 vs. 14.63 µmol/l, p<0.001), as well as lower serum albumin levels (38.2 vs. 41.1 g/l, p = 0.015), mean platelets (102.64 vs. 138.95/nl, p = 0.014) and mean leukocytes (4.02 vs. 5.68/nl, p = 0.002) at baseline as compared to those without decompensation. In the multivariate analysis the MELD score remained independently associated with hepatic decompensation (OR 1.56, 1.18–2.07; p = 0.002). When the patients were grouped according to their baseline MELD scores, hepatic decompensation occurred in 22%, 59%, and 83% of patients with MELD scores of 6–9, 10–13, and >14, respectively. Baseline MELD score was significantly associated with the risk for transplantation/death (p<0.001). Conclusions: Our data suggest that the baseline MELD score predicts the risk of hepatic decompensation during antiviral therapy and thus contributes to decision making when antiviral therapy is discussed in HCV patients with advanced liver cirrhosis.
- Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity (2012)
- Aim: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined. We performed a case-control study to investigate whether soluble CD81 in the exosomal serum fraction is associated with HCV replication and inflammatory activity. Patients and Methods: Four cohorts were investigated, patients with chronic hepatitis C (n = 37), patients with chronic HCV infection and persistently normal ALT levels (n = 24), patients with long term sustained virologic response (SVR, n = 7), and healthy volunteers (n = 23). Concentration of soluble CD81 was assessed semi-quantitatively after differential centrifugation ranging from 200 g to 100,000 g in the fifth centrifugation fraction by immunoblotting and densitometry. Results: Soluble CD81 was increased in patients with chronic hepatitis C compared to healthy subjects (p = 0.03) and cured patients (p = 0.017). Patients with chronic HCV infection and persistently normal ALT levels and patients with long term SVR had similar soluble CD81 levels as healthy controls (p>0.2). Overall, soluble CD81 levels were associated with ALT levels (r = 0.334, p = 0.016) and severe liver fibrosis (p = 0.027). Conclusion: CD81 is increased in the exosomal serum fraction in patients with chronic hepatitis C and appears to be associated with inflammatory activity and severity of fibrosis.
- Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus (2008)
- Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of drug resistance. In particular, two protease positions with the mutations V36A/G/L/M and T54A/S were associated with low to medium levels of drug resistance during viral breakthrough, together with only an intermediate reduction of viral replication fitness. These mutations are located in the protein interior and far away from the ligand binding pocket. Results Based on the available experimental structures of NS3-4A, we analyze the binding mode of different ligands. We also investigate the binding mode of VX-950 by protein-ligand docking. A network of non-covalent interactions between amino acids of the protease structure and the interacting ligands is analyzed to discover possible mechanisms of drug resistance. We describe the potential impact of V36 and T54 mutants on the side chain and backbone conformations and on the non-covalent residue interactions. We propose possible explanations for their effects on the antiviral efficacy of drugs and viral fitness. Molecular dynamics simulations of T54A/S mutants and rotamer analysis of V36A/G/L/M side chains support our interpretations. Experimental data using an HCV V36G replicon assay corroborate our findings. Conclusion T54 mutants are expected to interfere with the catalytic triad and with the ligand binding site of the protease. Thus, the T54 mutants are assumed to affect the viral replication efficacy to a larger degree than V36 mutants. Mutations at V36 and/or T54 result in impaired interaction of the protease residues with the VX-950 cyclopropyl group, which explains the development of viral breakthrough variants.
- Impact of soluble CD26 on treatment outcome and hepatitis C virus-specific T cells in chronic hepatitis C virus genotype 1 infection (2013)
- Background: Interferon and ribavirin therapy for chronic hepatitis C virus (HCV) infection yields sustained virological response (SVR) rates of 50–80%. Several factors such as non-1 genotype, beneficial IL28B genetic variants, low baseline IP-10, and the functionality of HCV-specific T cells predict SVR. With the pending introduction of new therapies for HCV entailing very rapid clearance of plasma HCV RNA, the importance of baseline biomarkers likely will increase in order to tailor therapy. CD26 (DPPIV) truncates the chemokine IP-10 into a shorter antagonistic form, and this truncation of IP-10 has been suggested to influence treatment outcome in patients with chronic HCV infection patients. In addition, previous reports have shown CD26 to be a co-stimulator for T cells. The aim of the present study was to assess the utility of CD26 as a biomarker for treatment outcome in chronic hepatitis C and to define its association with HCV-specific T cells. Methods: Baseline plasma from 153 genotype 1 and 58 genotype 2/3 infected patients enrolled in an international multicenter phase III trial (DITTO-HCV) and 36 genotype 1 infected patients participating in a Swedish trial (TTG1) were evaluated regarding baseline soluble CD26 (sCD26) and the functionality of HCV-specific CD8+ T cells. Results: Genotype 1 infected patients achieving SVR in the DITTO (P = 0.002) and the TTG1 (P = 0.02) studies had lower pretreatment sCD26 concentrations compared with non-SVR patients. Sixty-five percent of patients with sCD26 concentrations below 600 ng/mL achieved SVR compared with 39% of the patients with sCD26 exceeding 600 ng/mL (P = 0.01). Patients with sCD26 concentrations below 600 ng/mL had significantly higher frequencies of HCV-specific CD8+ T cells (P = 0.02). Conclusions: Low baseline systemic concentrations of sCD26 predict favorable treatment outcome in chronic HCV infection and may be associated with higher blood counts of HCV-specific CD8+ T cells.
- Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients (2014)
- Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-α and ribavirin for 24–72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002–1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975–0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000–1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073–2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271–4.695, P = 0.007) constituted the strongest predictors of treatment response. Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.
- SEMS vs cSEMS in duodenal and small bowel obstruction: High risk of migration in the covered stent group (2013)
- AIM: To compare clinical success and complications of uncovered self-expanding metal stents (SEMS) vs covered SEMS (cSEMS) in obstruction of the small bowel. METHODS: Technical success, complications and outcome of endoscopic SEMS or cSEMS placement in tumor related obstruction of the duodenum or jejunum were retrospectively assessed. The primary end points were rates of stent migration and overgrowth. Secondary end points were the effect of concomitant biliary drainage on migration rate and overall survival. The data was analyzed according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. RESULTS: Thirty-two SEMS were implanted in 20 patients. In all patients, endoscopic stent implantation was successful. Stent migration was observed in 9 of 16 cSEMS (56%) in comparison to 0/16 SEMS (0%) implantations (P = 0.002). Stent overgrowth did not significantly differ between the two stent types (SEMS: 3/16, 19%; cSEMS: 2/16, 13%). One cSEMS dislodged and had to be recovered from the jejunum by way of laparotomy. Time until migration between SEMS and cSEMS in patients with and without concomitant biliary stents did not significantly differ (HR = 1.530, 95%CI 0.731-6.306; P = 0.556). The mean follow-up was 57 ± 71 d (range: 1-275 d). CONCLUSION: SEMS and cSEMS placement is safe in small bowel tumor obstruction. However, cSEMS is accompanied with a high rate of migration in comparison to uncovered SEMS.
- A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C (2012)
- Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. Methodology/Principal Findings: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D3 (25[OH]D3) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061–2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D3<20 ng/mL) during all seasons, but 25(OH)D3 serum levels were not associated with treatment outcome. Conclusions/Significance: Our study suggests a role of bioactive vitamin D (1,25[OH]2D3, calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D3 is not a suitable predictor of treatment outcome.
- High prevalence of anti-HCV antibodies in two metropolitan emergency departments in Germany: a prospective screening analysis of 28,809 patients (2012)
- Background and Aims: The prevalence of hepatitis C virus (HCV) antibodies in Germany has been estimated to be in the range of 0.4–0.63%. Screening for HCV is recommended in patients with elevated ALT levels or significant risk factors for HCV transmission only. However, 15–30% of patients report no risk factors and ALT levels can be normal in up to 20–30% of patients with chronic HCV infection. The aim of this study was to assess the HCV seroprevalence in patients visiting two tertiary care emergency departments in Berlin and Frankfurt, respectively. Methods: Between May 2008 and March 2010, a total of 28,809 consecutive patients were screened for the presence of anti-HCV antibodies. Anti-HCV positive sera were subsequently tested for HCV-RNA. Results: The overall HCV seroprevalence was 2.6% (95% CI: 2.4–2.8; 2.4% in Berlin and 3.5% in Frankfurt). HCV-RNA was detectable in 68% of anti-HCV positive cases. Thus, the prevalence of chronic HCV infection in the overall study population was 1.6% (95% CI 1.5–1.8). The most commonly reported risk factor was former/current injection drug use (IDU; 31.2%) and those with IDU as the main risk factor were significantly younger than patients without IDU (p<0.001) and the male-to-female ratio was 72% (121 vs. 46 patients; p<0.001). Finally, 18.8% of contacted HCV-RNA positive patients had not been diagnosed previously. Conclusions: The HCV seroprevalence was more than four times higher compared to current estimates and almost one fifth of contacted HCV-RNA positive patients had not been diagnosed previously.
- Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers (2012)
- Background: Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly attributable to co-infection with hepatitis B or C. The impact of other risk factors, including prolonged exposure to combined antiretroviral therapy (cART) is poorly understood. Our aim was to determine the prevalence of liver fibrosis and associated risk factors in HIV-infected individuals based on non-invasive fibrosis assessment using transient elastography (TE) and serum biomarkers (Fibrotest [FT]). Methods: In 202 consecutive HIV-infected individuals (159 men; mean age 47 ± 9 years; 35 with hepatitis-C-virus [HCV] co-infection), TE and FT were performed. Repeat TE examinations were conducted 1 and 2 years after study inclusion. Results: Significant liver fibrosis was present in 16% and 29% of patients, respectively, when assessed by TE (≥ 7.1 kPa) and FT (> 0.48). A combination of TE and FT predicted significant fibrosis in 8% of all patients (31% in HIV/HCV co-infected and 3% in HIV mono-infected individuals). Chronic ALT, AST and γ-GT elevation was present in 29%, 20% and 51% of all cART-exposed patients and in 19%, 8% and 45.5% of HIV mono-infected individuals. Overall, factors independently associated with significant fibrosis as assessed by TE (OR, 95% CI) were co-infection with HCV (7.29, 1.95-27.34), chronic AST (6.58, 1.30-33.25) and γ-GT (5.17, 1.56-17.08) elevation and time on dideoxynucleoside therapy (1.01, 1.00-1.02). In 68 HIV mono-infected individuals who had repeat TE examinations, TE values did not differ significantly during a median follow-up time of 24 months (median intra-patient changes at last TE examination relative to baseline: -0.2 kPa, p = 0.20). Conclusions: Chronic elevation of liver enzymes was observed in up to 45.5% of HIV mono-infected patients on cART. However, only a small subset had significant fibrosis as predicted by TE and FT. There was no evidence for fibrosis progression during follow-up TE examinations.
- A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers (2012)
- Background and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians. Methods: Two HLA-DP gene variants (rs3077 and rs9277535) were analyzed for associations with persistent HBV infection and with different clinical outcomes, i.e., inactive HBsAg carrier status versus progressive chronic HBV (CHB) infection in Caucasian patients (n = 201) and HBsAg negative controls (n = 235). Results: The HLA-DPA1 rs3077 C allele was significantly associated with HBV infection (odds ratio, OR = 5.1, 95% confidence interval, CI: 1.9–13.7; p = 0.00093). However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6–11.1; p = 0.31). In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4–1.9; p = 1). Conclusions: A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. However, as a differentiation between different clinical courses of HBV infection was not possible, knowledge of the HLA-DPA1 genotype cannot be translated into personalized anti-HBV therapy approaches.


text:
Joseph Renow (jrenow)
1,324 reviewer rep
391 forum posts
joined Aug 8, 2013
38-year-old man
Evansville, IN
Email: private
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|Eleven Point (multi-day kayaking)
|September 10, 2013
In as few of words as possible…I would describe myself as someone who likes to go to remote places and stay there for days or weeks at a time. Typically this involves a backpack…a kayak…or a canoe…but I sometimes stay in one place and focus on an activity like fishing…or perhaps camping itself. What I do depends largely on who I go with…as well as when and where I go. I would say I have a lot of solo backpacking and paddling experience…but this is due to the fact that I like to go to remote places and sleep outdoors A LOT more than most of my would-be companions…not because I prefer it. Put differently…my particular experience has been shaped heavily by my desire to bring friends along with me…and what it takes to pursued them to do so. So while I can certainly speak to the needs and concerns of soloing…my perspective likely privileges what it takes to get others to come along on a week-long 100 mile adventure…more than it would the demands of successfully hiking the AT in three months.
Big Closet
After high school I made my first purchases of new gear…and well…I have not really stopped since. I do not consider myself a gear-head…but I do have a lot of stuff. In my defense…I buy only a few items a year…but over twenty years things just seem to accumulate. Do not misunderstand me…I am always looking to purge my closet of unused items…but what I do outdoors varies greatly…and that which is best for paddling down a spring-fed river in the summer is not always the same as that which is best to hike a rugged-trail for a week in the winter. Unlike a thru-hiker who might construct a single system which can handle a broad array of conditions…I take a very different approach…in that I have a large collection of items which generally work well together…and make possible a multitude of specialized systems.
My perspective on any particular matter is usually determined by the general formula (less work and cheaper > more work and expensive). Some things like good food + insect netting + inflatable mattresses defy the general formula…as their additional weight and cost are off-set by the magnitude of enjoyment they provide in a particular instance. For example…an inflatable mattress is both more expensive and requires more work than a foam pad…but if I use a foam pad I do not recover as fully…and my overall enjoyment is then less than what it would be if I had used an inflatable mattress. Given what I have said up to this point it is hardly difficult to imagine that I like to keep things light and stream-lined. However…while my pack-weights always range between 15 and 10 pounds…I would not call myself an ultra-lighter…in that I do not drop weight as a challenge in itself…I do it only to enjoy my time outdoors more.
Though I have slept outdoors in many places both within and outside of the US…I very much have a home-region that most of my experience is grounded in. This home-region roughly stretches from Missouri in the West + Tennessee in the South + Virginia in the East + Wisconsin in the North. Though not perfectly accurate...I would say I primarily spend my time in woodland river-valleys. For me then...water tends to be readily available and plentiful...as does heavy tree-cover...so both of these factors shape my opinions and perspective on choice of shelter + rain gear + hats + etc. in salient and significant ways. Similarly...saturated ground and high relative humidity during most of the year means that I tend to be less enthusiastic about wool base-layers and tents with poor ventilation. While I recognize the limitations of my perspective...and try to mitigate it as best I know how...it is of course impossible to be otherwise...as ALL claims of objectivity are necessarily false...and the stuff of scientific mythology.


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Cheap ski holidays in hundreds of ski resorts worldwide.
Nb: infants must be under the age of 2 and
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All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


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Bartow County Schools Campus Police Chief Dan Knowles said midday Thursday that a warrant had been taken for the 17-year-old male who allegedly stood up in homeroom and exposed himself to the class.
"Nobody can even figure why he dropped his pants in class," Knowles said.
Charges were delayed as officials tried to determine the ages of the other students in the class.
"[We have been] gathering information and making sure that you are doing the right charges, make sure there were no juveniles" in the class, Knowles said.
All students were found to be over the age of 17.
The teenager, who has no prior history, is facing misdemeanor public indecency charges and has received disciplinary action through the school.
At 5 p.m., Bartow County Sheriff's Office Public Information Officer Sgt. Jonathan Rogers said the teenager had not turned himself in on the outstanding warrant.
Knowles said his agency makes arrests "several times a week," but most are juveniles which are not reported through the Bartow County Sheriff's Office and open records procedures.
For the 2011-2012 school year, Knowles said his agency made 66 arrests and only "a handful" were over the age of 17.
Man huffs paint, harasses women at Wal-Mart
On Wednesday at 1:37 p.m. a deputy was dispatched to Wal-Mart, 101 Market Place Blvd., Cartersville, in reference to disorderly conduct.
Upon arrival, the deputy met with the Wal-Mart asset protection manager. The manager explained that offender, Gene Anderson, was walking through the store sexually harassing female employees. Anderson was allegedly huffing paint and bumping into female employees when he was asked to leave the premises.
According to the Bartow County Sheriff's Office incident report, while the deputy interviewed Anderson, he noticed a strong alcoholic odor and slurred speech.
Anderson was placed under arrest for disorderly conduct and transported to the Bartow County Jail.
Man robbed at gunpoint in Applebee's parking lot
At 11:31 p.m. Wednesday, Cartersville Police Department was dispatched to Applebee's, 185 Cherokee Place, in reference to an armed robbery. Upon arrival, police met with the victim who stated that an unknown white male robbed him at gunpoint. He informed the police that the suspect had left the scene.
The victim told police he was meeting with the suspect to purchase ecstasy in the Applebee's parking lot. He explained that the suspect got into the passenger side of his vehicle, pulled out a gun and said, "Give me everything you have."
The victim supposably did as he was told, handing over $50 and an iPhone 5. He then exited the vehicle and fled the scene, according to the incident report.
The complaintant said he had only met the suspect one other time. Allegedly he was driving a red, four-door passenger car with Tennessee registration.


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The Ocean Course on Kiawah Island will be the host of the 94th PGA Championship. The season's final major championship will take place August 9-12 on the challenging South Carolina course. Comfortable, durable and lightweight, the Heathland sweatshirt from Weatherproof is the best way to support your favorite golfers during this epic event. This quarter-zip jacket features a 2012 PGA Championship logo embroidered on the left chest, an Olympic collar, a woven Weatherproof tag at the side and an ultra-lightweight construction to allow durability and flexibility. This is the perfect sweatshirt for those chilly days, giving you the ultimate comfort as you watch the championship!
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The Precor EFX 576i is a high-end offering and is constructed from quality components such as sealed bearings, self-lubricating bronze bushings, over-sized axles, and double polyurethane wheels.
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Who are the four 4-H'ers, which club did they belong to and what was the reason for the photo?
Last week's Remember When mystery photo, below left, showed the intersection of East Street and Grant Line Road in the early 1950s.
The photo looks south on East Street, showing the "flat top" houses on the east side of the street.
No one seems to know what the building was the southwest corner of the intersection. That corner became the location of the Tracy Bowl (now West Valley Bowl), constructed in the late 1950s.
• If you know the answer or can't wait until next week to get it, email firstname.lastname@example.com or call 830-4234.


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We had a great hike with Erich (BlueDog) on Saturday for Flags on the 48. The Lincoln/Lafayette loop (Falling Waters/Franconia Ridge/Old Bridle Path) was extremely busy, but the crowds don't bother us for the special occasions - just like Seek-the-Peak.
Everyone was in great spirits and very friendly!
Trip report can be found here:


text: Apply this non-toxic latex to seal and protect the cork footbed. The handy brush-in-lid applicator minimizes cleanup. Cork Life dries clear--but apply carefully, as it will stain non-cork material. Your new Birkenstocks are sent to you with a fresh application of Cork Life. Reapply whenever the cork looks dull.2 oz. jar


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R4i 3DS team released new Wood R4 V1.45 kernel on Feb 27th. It is the latest software for R4i 3DS Gold card. It improved the core and compatibility. Users who is playing DS games on Nintendo 3DS console with a R4i 3DS card, can update the software to the latest Wood R4i V1.45 version. It can be download in r4ids.cn or our download page.
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Posted : 03/03/2012 01:37:16
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Posted : 14/02/2012 00:19:51


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Meet Patrice. She's passionate about empowering young women of color though innovative digital content.
With her skill sets in journalism, entrepreneurism and new media, she aims to help make young women stronger, more knowledgeable and more confident.
Patrice loves motivating people to be their most dynamic and creative selves by hurdling obstacles and following their passions.
Her work can be found at places like The Huffington Post, NBC, EBONY.com, and BET.com.


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Since 1966 K-Swiss has represented innovation, quality, performance and style. Its signature K-Swiss 'Classic', the first leather tennis shoe, made its debut at Wimbledon in 1966 and more than 40 years later, is still a style staple both on and off the court. Today K-Swiss premium sports heritage has expanded from tennis footwear, to also lifestyle, running, training, nautical and free-running foot-wear that stands up to the performance demands of world-class athletes and trendsetters alike.
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"Concepts of religion may now be goals of science and engineering."
I have no idea when hotels started using an automated dialer to provide wake-up calls. This one is also personalized.
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Physicists Build Repulsor / Tractor Beam
'Brandon swung mighty tractor beams upon the severed halves of the Jovian vessel...'
High Fidelity Produces More Expressive Avatars!
'They are the audiovisual bodies that people use to communicate with each other...'
Will You Upload Your Mind Anytime Soon?
And if so, how long will the copy last?
Students! NASA Wants To 3D Print Your Tool Design In Space!
'Mass-produced only in the orbiting factories...'
Amazing ARES Augmented Reality Sandbox
'First he showed him where the input and output of his brand-new kingdom were, and how to program wars...'
'3D Light Sculpture' Projected Directly Onto Retina
'...projects directly on the retina of the eye '
3D Printer Vending Machine Dispenses Dreams
'Nanofax AG offers a technology that digitally reproduces objects, physically, at a distance.'
Why Not Nurse Grandma With A Robot?
'She's made of a combination of springs, levers, acoustic instruments...'
Flock Of Minisats Will Image The Earth
'We... dropped roughly a thousand eyes on Beta Hydri IV.'
Robert Heinlein, Your Self-Driving Car Is Almost Ready!
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Your young Giants fan wouldn't let poor weather stop him from supporting the team. When the mercury starts to drop, give him this Micro Polar fleece jacket so he can warm up and rock his New York pride. This quarter zip jacket sports team colors, an embroidered team logo on the left chest and "Giants" lettering across the back yoke to show the world where his loyalties lie. You'll never have to worry about him coming home from the game with a cold as long as he's wearing this warm and spirited jacket.
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Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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The Tigers recorded both victories on the road, besting Orestimba High of Newman 89-33 on Nov. 27 and beating Valley High of Sacramento 64-57 on Thursday, Nov. 29.
"Our boys were eager to get the season started — we couldn't have asked for a better start," said Patterson coach Agustin Arreola. "The team played a selfless brand of basketball that I hope we will sustain throughout the season."
Cariaun Williams (four rebounds, three assists) and Justin Rodriguez (3-for-6 on 3-point shots) each scored 13 points to lead a balanced offense as Patterson routed Orestimba.
"I was pleased with our ability to share the basketball and with the level of focus throughout the game," Arreola said. "Blowout games tend to get sloppy with ill-advised shots and bad defense, but our kids never let up."
Jordan Dinu (three rebounds, two steals) scored 13 points and Keegan Sanchez (seven assists, six steals) had 10 points for the Tigers (2-0) in the season opener for both teams.
"Unfortunately, there are only 32 minutes in a game, so playing everyone is one of the most difficult things for a coach," Arreola said. "Fortunately, everyone played a good amount of time and excelled on the court."
The Patterson team — which led 52-12 at halftime — shot 52 percent for the game, pulled down 41 rebounds and had 25 assists and 26 steals.
Jordan Levu (seven rebounds, five assists) and Mikey Smith (five rebounds, four steals) each netted eight points for the Tigers.
The trio of Levu, Rodriguez and Williams accounted for much of Patterson's offense in the nonleague road win against Valley. Despite that offensive punch, it took a full-team defensive effort to pull away from the persistent Vikings in the second half.
"It was a tough and ugly win. Valley is a resilient team that we couldn't put away," Arreola said. "We didn't show the same discipline and focus we displayed against Orestimba. We forced too many passes, rushed shots and lacked discipline on defense. Fortunately, we made enough plays to pull out the win."
Levu scored a team-high 16 points and grabbed 14 rebounds to lead the visiting Tigers to their victory. Rodriguez made four of his five 3-point attempts and finished with 14 points.
"Jordan and Justin could be the key to our season," Arreola said. "They picked up the slack for a few of our key players who struggled to get going on offense. If they can play the way they did against Valley throughout the season, we will be tough to beat."
Williams finished with 12 points, three assists, three rebounds and two steals, and Avion Warmsley (five points, two rebounds) showed a strong effort in the victory, Arreola added.
"Despite struggling against Valley, the fact is we won a road game in Sacramento against a playoff team," Arreola said. "Our kids should be proud of that accomplishment, while looking to learn from our mistakes."
Patterson will continue the season at 7 p.m. Thursday, Dec. 11, at Pitman High in Turlock.
Junior varsity
The JV Tigers beat Orestimba 71-54 on Nov. 27 and Valley High 62-35 on Thursday.
Damarrio Hammonds scored 18 points to lead three players in double figures as Patterson surged to a big early lead and cruised past Orestimba. Mylek McDowell scored 11 points and Robert Williams added 10 for the Tigers.
Two days later, Hammonds, McDowell and Gurkirt Heerey posted double figures as Patterson rolled over Valley.
McDowell scored a game-high 22 points to go with four rebounds and six steals. Hammonds (three steals) scored 14 points, and Heerey (nine rebounds) had 10.
Kevin Phelps added 11 rebounds and six steals for the Tigers (2-0).
Contact Marc Aceves at 892-6187, ext. 28, or email@example.com.


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You might not have a million bucks to fill this Diamond ID wallet with, but you'll feel like a million bucks every time you break it out! This bi-fold ID holder from Diamond Supply Co. features a large embossed brand logo on one side and a small metal logo on the other. The inside of this slim wallet boasts a clear ID slot and two card slots. Keep it simple and maybe one day you'll have a million dollars!
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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The Robinson Library is the main campus library and has resources for all subjects except medicine and law.
It was named after Philip Robinson, a bookseller in the city and benefactor to the library, in 1989. £1.6M has been invested in the Robinson Library over the last 2 years including a big refurbishment over the 2012 summer vacation.
Robinson Library
Jesmond Road West
Newcastle University
Newcastle upon Tyne
The Walton Library is the faculty library for Medical Sciences. It serves the Schools of Medicine, Dentistry, Psychology and Biomedical Sciences as well as the Graduate School and Research Institutes of the Faculty.
It is named after Lord John Walton, former Dean of Medicine at the University and renowned neurologist.
Walton Library
Medical School
Framlington Place
Newcastle upon Tyne
The Law Library is located in Newcastle Law School and provides extensive resources for all those engaged in learning and researching law.
Law Library
Newcastle Law School
Newcastle University
21-24 Windsor Terrace
Newcastle upon Tyne
Unlike many academic libraries, Newcastle University Library has access to state-of-the-art off-campus storage facilities, meaning we can keep less-used material for much longer than some other academic libraries.
The facilities have just been refurbished and in total provide us with an additional 29 kilometres of storage space, which are currently housing back-runs of journals and books which haven't been consulted for over 5 years (longer in some subject areas).
Members of the library can visit the Research Reserve to consult items by appointment only between the hours of 10am – 1pm (see contact details below). Items can also be requested for collection at a library or delivered electronically.
Unit 1
Dukesway Court
Team Valley
The study room is furnished to provide access to the collections housed at the Team valley Research Reserve. As well as study desks for library use, with space for researchers to use laptops.
There is now full wireless access in this area and there are 2 cluster pcs which can be used by anyone with a Campus ID and password.
In addition there is a larger table for map, picture, university archive, current records or archaeological collections study. Please note that archaeological collections may only be accessed by prior arrangement with the curator, Andrew Parkin.
Trolleys of books or journals, or archive boxes, can be brought directly to the desk. For browsing long journal runs, access to the compact shelving can be organised by special arrangement.
Normal daily access is available by appointment only with the Research Reserve Team, Monday – Friday between the hours of 10.00 a.m. and 1.00 p.m. Access outside of these hours can organised given sufficient notice. The team can be contacted by email either to firstname.lastname@example.com or email@example.com or by telephone on 0191 208 6986 (at Robinson Library) 0191 4403606 (at Team valley) or Christine Stevens, team manager, can be contacted on 07816146530.
Dukesway may be accessed via the A1 from either Lobley Hill roundabout, via Kingsway, or Low Fell roundabout, via Retail World. The Research Reserve building is directly opposite Valley Electrical Supplies and Northumbria Fine Foods and lies between Foster Court.
A regular bus service runs from Newcastle, the Team Valley Express no. 91, with a stop directly outside.


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I was just given a Martin Onza as a gift, and I'm trying to identify the exact model so I can get some more information about it. The only thing that I can find is a small piece of clear plastic on it that appears to say "cougar". Everything else is faded off from that tag, so I'm kinda in the dark as to what it could be.
Breif description - It's all camo w/ a wood grip. Martin Archery logo carved into the wood grip. ONZO with what appears to be a large cat (lion, cougar, cheetah, something like that) is written on the upper and lower portions of the bow.
Any thoughts? I'll try to take pictures and post them to help with the description as soon as I get a chance.


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5 awesome pie pairings to try now!
I'm 14 and I haven't crushed on anyone, guys or girls. Is something wrong with me?
To keep or to share? How to know when to tell an adult a secret
The biggest OMG celeb moments of the week
Feel-Good Friday: Little Willow's costume craze is super cute
Sporty chic: Cool workout clothes you can actually wear beyond the gym
5 cute ways to rock a beanie
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Ever feel a little jealous? Spill for an upcoming issue of the mag!
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by Enriquette96 on 12/14/2012 1:51:20 AM
Fierce females
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My new limbs were on my front porch when I got home from work yesterday.
I put my bow all back togeather and cranked the limb bolts down and backed them out an 1/8 turn and sent the tiller, then went to draw the bow.
I couldn't pull it back, I thought...Dang I must be getting real old...lol I thought I might of routed the cables wrong or something so I grabbed my backup Shadowcat and they matched up. Now the new limbs are 60 pound max limbs and I know I can pull 60 pounds. So I backed the limb bolts out untill it felt right and put it on my scale, it read 57 pounds. The limbs are backed out to where the bolts are just sticking out of the barrle nuts and there is over a 1/4" gap between the limb and riser.
I took the bow out to my back yard and shot it, it feels real mushy, when it drops into the valley you can hardly feel it and when I loose the arrow it just kind of goes mush and is shooting real low to the left.
I am going to pull it apart tonight when I get home to make sure everything is right, but this has me wondering what is going on. I will do an update tonight once I ter into the bow.


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After a strong performance in the qualification and elimination races, the athlete from Winterthur missed a top three at the 4X world championship race.
The chances to win a medal or even the title were good for Roger Rinderknecht: the native of Zurich won the qualification race and showed convincing performances during the elimination races. A bad start destroyed all the chances for the world cup race winner at Val di Sole to win a medal. Roger Rinderknecht attributes his misfortune to the bad light conditions which disturbed him already during the previous races. Vainly Roger Rinderknecht tried to make up the leeway on his opponents, which was pretty hopeless without any mistakes of his competitors.
For Roger Rinderknecht the forth place at the 4X WC in Mont-Saint Anne was his third ranking at this place what disappointed him after having won the qualification race. Although he missed the medal ranks his qualification for the final of the 4X WC shows his high-level qualities in 4X races. Nonetheless, the BMC athlete stays confident for the world championships held next year in Champéry, where he will do everything to upgrade this year's result.


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The Ladies Night Freeroll Tournament is a single night No Limit Texas Hold'em multi-table tournament for ladies only with no buy-in and a $600 guaranteed pot. Click Here for more information.