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Received Nov. 16, 2010; revision received Feb. 10, 2011; accepted Feb. 14, 2011.
Dr. Rush has received consulting fees from Advanced Neuromodulation Systems, Best Practice Project Management, Brain Resource, Otsuka, and the University of Michigan; he has received consultant/speaker fees from Forest; he has received consultant fees from and owns stock in Pfizer; he has received author royalties from Guilford Publications, Healthcare Technology Systems, and the University of Texas Southwestern Medical Center; and he has received research support from the National Institute of Mental Health. Dr. Trivedi has received research support from the Agency for Healthcare Research and Quality, Corcept, Cyberonics, Merck, NARSAD, the National Institute of Mental Health, the National Institute on Drug Abuse, Novartis, Pharmacia & Upjohn, Predix (EPIX), Solvay, and Targacept; he has received consulting and speaker fees from Abbott, Abdi Ibrahim, Akzo (Organon), AstraZeneca, Bristol-Myers Squibb, Cephalon, Eli Lilly, Evotec, Fabre Kramer, Forest, GlaxoSmithKline, Janssen, Johnson & Johnson, Meade Johnson, Medtronic, Neuronetics, Otsuka, Parke-Davis, Pfizer, Sepracor, Shire Development, VantagePoint, and Wyeth. Dr. Fava has received research support from Abbott, Alkermes, Aspect Medical Systems, AstraZeneca, BioResearch, BrainCells, Bristol-Myers Squibb, CeNeRx BioPharma, Cephalon, Clinical Trials Solutions, Clin-tara, Covidien, Eli Lilly, EnVivo, Euthymics Bioscience, Forest, Ganeden Biotech, GlaxoSmithKline, Icon Clinical Research, i3 Innovus/Ingenix, Johnson & Johnson, Lichtwer, Lorex, NARSAD, the National Center for Complementary and Alternative Medicine, the National Institute on Drug Abuse, NIMH, Novartis, Organon, Pamlab, Pfizer, Pharmavite, Photothera, RCT Logic, Roche, Sanofi-Aventis, Shire, Solvay, Synthelabo, and Wyeth; he has served as adviser or consultant to Abbott, Affectis, Alkermes, Amarin, Aspect Medical Systems, AstraZeneca, Auspex, Bayer, Best Practice Project Management, BioMarin, Biovail, BrainCells, Bristol-Myers Squibb, CeNeRx BioPharma, Cephalon, Clinical Trials Solutions, CNS Response, Compellis, Cypress, DiagnoSearch Life Sciences, Dinippon Sumitomo, DOV, Edgemont, Eisai, Eli Lilly, ePharmaSolutions, EPIX, Euthymics Bioscience, Fabre-Kramer, Forest, GenOmind, GlaxoSmithKline, Grunenthal, i3 Innovus/Ingenix, Janssen, Jazz, Johnson & Johnson, Knoll, Labopharm, Lorex, Lundbeck, MedAvante, Merck, MSI Methylation Sciences, Naurex, Neuronetics, NextWave, Novartis, Nutrition 21, Orexigen, Organon, Otsuka, Pamlab, Pfizer, PharmaStar, Pharmavite, PharmoRx, Precision Human Biolaboratory, Prexa, PsychoGenics, Psylin Neurosciences, Puretech Ventures, RCT Logic, Rexahn, Ridge Diagnostics, Roche, Sanofi-Aventis, Schering-Plough, Sepracor, Servier, Solvay, Somaxon, Somerset, Sunovion, Synthelabo, Takeda, Tal Medical, Tetragenex, Transcept, TransForm, and Vanda; he has received speaking or publishing fees from Adamed, Advanced Meeting Partners, the American Psychiatric Association, the American Society of Clinical Psychopharmacology, AstraZeneca, Belvoir Media Group, Boehringer Ingelheim, Bristol-Myers Squibb, Cephalon, CME Institute/Physicians Postgraduate Press, Eli Lilly, Forest, GlaxoSmithKline, Imedex, MGH Psychiatry Academy/Primedia, MGH Psychiatry Academy/Reed Elsevier, Novartis, Organon, Pfizer, PharmaStar, United BioSource, and Wyeth; he owns stock in Compellis; he has a patent for SPCD, a patent application for a combination of azapirones and bupropion in major depressive disorder, and a patent for research and licensing of SPCD with RCT Logic and Lippincott, Williams & Wilkins; and he receives copyright royalties for the MGH CPFQ, SFI, ATRQ, DESS, and SAFER. Dr. Kurian has received research support from Evotec, Pfizer, and Targacept. Dr. Warden has owned stock in Bristol-Myers Squibb and Pfizer in the past 5 years. Dr. Husain has received research support from Cyberonics, Magstim, Neuronetics, NIH/NIMH, the Stanley Foundation, and St. Jude Medical; he has also served on advisory boards for AstraZeneca, BMS, Forest, and Novartis. Dr. Cook has served as an adviser and consultant for Ascend Media, Bristol-Myers Squibb, Cyberonics, Janssen, NeuroSigma, and the U.S. Departments of Defense and of Justice; he has served on the speakers bureaus for Bristol-Myers Squibb, Neuronetics, and Wyeth/Pfizer; he has received research support from Aspect Medical Systems/Covidien, Cyberonics, Eli Lilly, Neuronetics, NIH, Novartis, Pfizer, and Sepracor; his patents on biomedical devices are assigned to the Regents of the University of California. Dr. Shelton has received grant/research support from Abbott, AstraZeneca, Eli Lilly, GlaxoSmithKline, Janssen, Pamlab, Pfizer, Sanofi, and Wyeth; he has been a paid consultant to Evotec, Janssen, and Sierra Neuropharmaceuticals; and he has served on speakers bureaus for Abbott, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen, and Wyeth. Dr. Lesser has received research support from Aspect Medical Systems and NIMH. Dr. Kornstein has received grants/research support from Boehringer-Ingelheim, Bristol-Myers Squibb, Eli Lilly, Forest, the National Institute of Mental Health, Novartis, Pfizer, Rexahn, Takeda, and Wyeth; she has served on advisory boards for Bristol-Myers Squibb, Dey, Eli Lilly, Forest, Pfizer, PGx Health, Takeda, and Wyeth; and she has received book royalties from Guilford Press. Dr. Wisniewski reports financial relationships with Cyberonics (2005—2009), ImaRx Therapeutics (2006), Bristol-Myers Squibb (2007—2008), Organon (2007), Case-Western University (2007), Singapore Clinical Research Institute (2009), Dey (2010), and Venebio (2010). The other authors report no financial relationships with commercial interests.
Funded by NIMH under contract N01 MH-90003 to the University of Texas Southwestern Medical Center at Dallas (principal investigators, A.J. Rush and M.H. Trivedi). Forest Pharmaceuticals, GlaxoSmithKline, Organon, and Wyeth Pharmaceuticals provided medications for this trial at no cost.
The content of this publication does not necessarily reflect the views or policies of the U.S. Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. NIMH had no role in the drafting or review of the manuscript or in the collection or analysis of the data.
Address correspondence and reprint requests to Dr. Trivedi, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9119; firstname.lastname@example.com (e-mail).
16, 2010; Revised
10, 2011; Accepted
14, 2011.
Copyright © American Psychiatric Association
Two antidepressant medication combinations were compared with selective serotonin reuptake inhibitor monotherapy to determine whether either combination produced a higher remission rate in first-step acute-phase (12 weeks) and long-term (7 months) treatment.
The single-blind, prospective, randomized trial enrolled 665 outpatients at six primary and nine psychiatric care sites. Participants had at least moderately severe nonpsychotic chronic and/or recurrent major depressive disorder. Escitalopram (up to 20 mg/day) plus placebo, sustained-release bupropion (up to 400 mg/day) plus escitalopram (up to 20 mg/day), or extended-release venlafaxine (up to 300 mg/day) plus mirtazapine (up to 45 mg/day) was delivered (1:1:1 ratio) by using measurement-based care. The primary outcome was remission, defined as ratings of less than 8 and less than 6 on the last two consecutive applications of the 16-item Quick Inventory of Depressive Symptomatology—Self-Report. Secondary outcomes included side effect burden, adverse events, quality of life, functioning, and attrition.
Remission and response rates and most secondary outcomes were not different among treatment groups at 12 weeks. The remission rates were 38.8% for escitalopram-placebo, 38.9% for bupropion-escitalopram, and 37.7% for venlafaxine-mirtazapine, and the response rates were 51.6%—52.4%. The mean number of worsening adverse events was higher for venlafaxine-mirtazapine (5.7) than for escitalopram-placebo (4.7). At 7 months, remission rates (41.8%—46.6%), response rates (57.4%—59.4%), and most secondary outcomes were not significantly different.
Neither medication combination outperformed monotherapy. The combination of extended-release venlafaxine plus mirtazapine may have a greater risk of adverse events.
Major depressive disorder is a serious, disabling, life-shortening illness with a high lifetime risk: 7%—12% for men and 20%—25% for women (1). It is often recurrent, episodes frequently last more than 2 years (i.e., are chronic) (2), and interepisode recovery is often incomplete (3). Chronic episodes and recurrent courses are associated with worse prognoses and are more likely to need longer-term treatment (4—7).
Remission is the aim of treatment (8) because patients whose depression has remitted have better functioning and a better prognosis than those without remission (5). Antidepressant medications, when used as monotherapies in placebo-controlled registration trials, typically result in 30%—35% remission rates (8). Lower remission rates (25%—30%) are reported for patients with more chronic depressions (5, 6).
Could remission rates be increased with a combination of two antidepressant medications used together as initial treatment? Other branches of medicine often employ combination treatments at the outset of chronic illness, especially for the more severely ill (9, 10). In depression treatment, when a single antidepressant medication is not effective (7, 11), a second is often added to the first, with some evidence for efficacy (12). It also appears that some antidepressant medications work for some patients but not for others. A combination of two medications might therefore increase the spectrum of patients who could benefit from the combination (13). Furthermore, an unexpected synergy between medications might produce a rapid onset of benefit, so that fewer patients would drop out of treatment, which, in turn, might enhance remission rates. From a pharmacological perspective, a combination might affect a wider range of neurotransmitter or neuromodulator systems, which would enhance efficacy for some patients (14—16). Finally, clinical experience and a few small randomized, short-term trials (13, 17, 18) suggest that some combinations can be more effective than monotherapy. On the other hand, treatment guidelines do not recommend such an approach as a first treatment step, and the risk of serious adverse events or intrusive side effects has not been fully evaluated. Thus, combining antidepressants as a first-step treatment for depression needs proper evaluation.
The Combining Medications to Enhance Depression Outcomes (CO-MED) trial was designed as a proof-of-concept study to determine whether either of two different antidepressant medication combinations would produce a higher remission rate at 12 weeks and, secondarily, after 7 months than monotherapy with a selective serotonin reuptake inhibitor (SSRI) as a first-step treatment in outpatients with chronic or recurrent major depression. We also compared the treatment effects on patient retention, side effect burden, and quality of life.
CO-MED was a 7-month single-blind, randomized, placebo-controlled trial that compared the efficacy of each of two medication combinations with escitalopram plus placebo in a 1:1:1 ratio as first-step treatment, including acute-phase (12 weeks) and long-term continuation (total 7 months) treatment. We planned a study group of 660 outpatients with nonpsychotic major depression from six primary and nine psychiatric care sites to allow detection of roughly a 15% difference in remission rates between each combination and escitalopram-placebo (with an expected remission rate of 35%). This difference was viewed as sufficiently large to affect practice since it approximates the benefit of a single antidepressant medication over placebo in successful antidepressant registration trials (8).
Clinical sites were selected on the basis of our prior experience and their performance in the Sequenced Treatment Alternatives to Relieve Depression trial to ensure 1) adequate patient flow, 2) committed administrative support, 3) adequate minority representation, and 4) adequate representation of both primary and psychiatric care sites.
Potential participants were screened at each clinical site with each site's standard procedure (variable across sites). Most sites used two to nine questions from the Patient Health Questionnaire (19, 20). Patients identified by screening saw their study clinicians and clinical research coordinator to determine study eligibility following written informed consent.
Broad inclusion and minimal exclusion criteria ensured a reasonably representative participant group. The outpatient enrollees were 18—75 years old and met the DSM-IV-TR (21) criteria for either recurrent or chronic (current episode lasting at least 2 years) major depression according to a clinical interview and confirmed with a DSM-IV-based symptom checklist completed by the clinical research coordinator. Eligible participants had to have an index episode lasting at least 2 months and had to score at least 16 on the 17-Item Hamilton Depression Rating Scale (HAM-D) (22). Those with any psychotic illness or bipolar disorder and those in need of hospitalization were ineligible. (For a complete list of exclusion criteria, see http://clinicaltrials.gov/ct2/show/NCT00590863.)
The study protocol and all consent and study procedures were approved by the institutional review boards at the national coordinating center (University of Texas Southwestern Medical Center at Dallas), the University of Pittsburgh data coordinating center, and each participating regional center and relevant clinical site.
Sociodemographic and illness features were recorded at baseline. The anxiety subscale of the HAM-D was used to establish the presence of anxious features at baseline (23). This anxiety/somatization factor, derived from a factor analysis of the HAM-D conducted by Cleary and Guy (24), includes six items from the original 17-item version: item 10 (anxiety, psychic), item 11 (anxiety, somatic), item 12 (somatic symptoms, gastrointestinal), item 13 (somatic symptoms, general), item 15 (hypochondriasis), and item 17 (insight). A HAM-D anxiety/somatization factor score of 7 or higher indicated anxiety. The HAM-D administered at baseline by research outcome assessors (not located at any clinical site) was used to define anxious features. The self-report Psychiatric Diagnostic Screening Questionnaire (25) was used to establish the presence of current axis I disorders. The Self-Administered Comorbidity Questionnaire (26) established the presence, severity, and functional impact of a range of common concurrent general medical conditions.
A 12-week study period was chosen for the primary analysis to provide sufficient time for maximal dosing (if needed) and to allow most cases of depression that could remit to do so (27). Treatment visits were planned at baseline and weeks 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, and 28. No washout was required, but clinicians could choose a washout period if they thought it to be clinically advisable. Dose adjustments were based on measurement-based care following an operations manual to provide personally tailored but vigorous dosing (28). Dose adjustments were based on the score on the 16-item Quick Inventory of Depressive Symptomatology—Clinician-Rated (QIDS-C) (29), which was extracted from the 30-item Inventory of Depressive Symptomatology—Clinician-Rated (IDS-C) (30), and the score on the Frequency, Intensity, and Burden of Side Effects Rating Scale (31) obtained at each visit.
Treatment was randomly assigned, stratified by clinical site according to a web-based randomization system (32). Random block sizes of three and six were used to minimize the probability of identifying the next treatment assignment. Dosing schedules were based on prior reports (33—35). Doses were increased only in the context of acceptable side effects. Participants could exit the study if unacceptable or intolerable side effects occurred and could not be resolved with dose reduction or medication treatment of the side effects.
Escitalopram treatment was begun at 10 mg/day (one pill) and could be increased to 20 mg/day (two pills) at 4 weeks if the score on the QIDS-C was higher than 5 (if side effects allowed). Pill placebo was started at week 2, with the option to increase it to two pills at week 4 if the QIDS-C score was higher than 5 (if side effects allowed).
The dose of sustained-release bupropion was 150 mg/day initially and was increased to 300 mg/day at the week 1 visit. Escitalopram was begun at 10 mg/day at the week 2 visit. At week 4, the bupropion dose was raised to 400 mg/day (200 mg b.i.d.) and/or the escitalopram dose was raised to 20 mg/day if the score on the QIDS-C was higher than 5 (if side effects allowed). At week 6 and beyond, doses could be increased up to a maximum of 400 mg/day (200 mg b.i.d.) for bupropion and 20 mg/day for escitalopram if the QIDS-C score was above 5 (if side effects allowed).
Treatment with extended-release venlafaxine was begun at 37.5 mg/day for 3 days and then raised to 75 mg/day. At week 1, the dose was raised to 150 mg/day. At week 2, if the score on the QIDS-C was above 5, mirtazapine was added at a dose of 15 mg/day. At week 4, if the QIDS-C score was above 5, the venlafaxine dose was raised to 225 mg/day and/or the mirtazapine dose was increased to 30 mg/day. At week 6, if the QIDS-C score was higher than 5, the mirtazapine dose could be raised to 45 mg/day, the maximum dose. At week 8, if the score was above 5, the venlafaxine dose could be raised to 300 mg/day, the maximum allowed.
The first medication given in each treatment group was open label (both participant and study personnel were unblinded), while each second medication was given in a single-blind fashion (participant only) to ensure that the participants all took two types of pills. Specifically, in the escitalopram-placebo cell, placebo administration was blinded. For the bupropion-escitalopram combination, escitalopram was blinded. For venlafaxine-mirtazapine, mirtazapine was blinded. The participants remained blinded to the second medication throughout the 7-month study. The research coordinators and physicians were not blinded, to maximize safety and facilitate informed flexible dosing decisions.
Only protocol antidepressant medications were allowed. Treatments with possible antidepressant effects were proscribed, as were anxiolytics, sedative-hypnotics, and depression-targeted, empirically validated psychotherapies for depression. Other therapies (e.g., supportive, couples, occupational) were allowed, as were medications for any general medical condition. Given the inhibition of the 2D6 isoenzyme by sustained-release bupropion, we alerted clinicians about nonprotocol medications (e.g., type 1C antiarrhythmics, beta-blockers) for which serum or dose adjustments might be needed. Medications to treat antidepressant medication side effects were allowed; administration was based on clinician judgment.
Outcome measures were assessed at baseline and all treatment visits. The primary outcome, symptom remission, was based on the score on the 16-item Quick Inventory of Depressive Symptomatology—Self-Report (QIDS-SR) at 12 weeks (29). The designation of remission was based on the last two consecutive measurements during the 12-week acute-phase trial to ensure that a single "good week" was not falsely signaling remission. At least one of these ratings had to be less than 6, while the other had to be less than 8. If participants exited before 12 weeks, their last two consecutive scores were used to determine remission. Those without two postbaseline measures were considered not to have remission.
Physicians were advised that participants could exit the study if they had received a maximally tolerated dose(s) for 4 or more weeks by week 8 without obtaining at least a 30% reduction from the baseline score on the QIDS-C. They could enter continuation treatment (weeks 12—28) if they had received an acceptable benefit (defined as a QIDS-C score of 9 or less by week 12) or if they reached a score of 10—13 and the clinician and participant judged the benefit to be substantial enough to recommend treatment continuation. Thus, virtually all participants entering the continuation phase had at least a 40% reduction in the QIDS-C score. If a participant exited the study at any time, a study exit form was completed. Clinical research coordinators attempted to contact all participants who did not come for a final exit visit.
Secondary outcomes included attrition, anxiety as reflected in the score on the anxiety subscale of the IDS-C (30), functioning as measured by the Work and Social Adjustment Scale (36), quality of life as measured by the Quality of Life Inventory (37), side effect burden as measured by the Frequency, Intensity, and Burden of Side Effects Rating Scale (31), and specific side effects as measured by the Systematic Assessment for Treatment Emergent Events—Systematic Inquiry (38). Manic symptoms were assessed by using the Altman Self-Rating Mania Scale (39), and cognitive and executive dysfunction was assessed by means of the Cognitive and Physical Functioning Questionnaire (40).
Descriptive statistics, including measures of central tendency and dispersion, were computed for continuous data. Frequency distributions were estimated for categorical data.
Outcome analyses were conducted with the full group, on the basis of the intention-to-treat principle. Each combination therapy was compared to the monotherapy. To control for the overall type I error rate, a type I error rate of 0.025 was planned for the comparison of each combination treatment with monotherapy. The analytic approach for the two comparisons was identical. A chi-square test was used to compare the remission rates across the treatment groups. Fisher's exact test was used when the expected cell frequencies were less than 5. For binary outcomes (e.g., remission), bivariate logistic regression models were fit to estimate the effect of treatment on outcome. Multivariable logistic regression models were then fit to control for the effect of regional center and baseline characteristics that were not balanced across treatment groups. A similar approach was used for discrete outcomes with more than two levels, except a polytomous logistic regression model was used. For continuous outcomes, a t test was used to compare the means when distributions were normal, and the nonparametric Kruskal-Wallis test was used when distributions were nonnormal. Linear regression models were used to compare the means after controlling for regional center and baseline characteristics not balanced across treatment groups. A general linear model with a negative binomial distribution and log link was estimated for outcomes with severely nonnormal distributions (the last number of worsening adverse events indicated by the Systematic Assessment for Treatment Emergent Effects and the score on the IDS-C anxiety subscale).
Figure 1 contains a chart specifying how the study group was formed. From March 2008 through February 2009, the study enrolled 665 participants. They were moderately to severely ill, as indicated by a mean HAM-D score of 23.8 (SD=4.8) and a score on the QIDS-SR of 15.5 (SD=4.3). About half of the participants were unemployed, and two-thirds were female (Table 1). Over three-quarters had recurrent major depression (Table 2). More than one-half of the participants were in a chronic current major depressive episode. About one-third had both recurrent and chronic depression. Almost one in 10 had made a prior suicide attempt, and for over 40% the illness had begun before age 18. Most (75%) had anxious features. Concurrent comorbid axis I and axis III disorders were common (Table 3).
Recruitment and Treatment of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
Baseline Sociodemographic Characteristics of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
a For some variables, data were not available for all subjects.
b Chi-square analysis for categorical data and t tests for continuous data.
c Significantly different from monotherapy.
Baseline Clinical Characteristics of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
a For some variables, data were not available for all subjects. HAM-D, 17-item Hamilton Depression Rating Scale (22). IDS-C, 30-item Inventory of Depressive Symptomatology—Clinician-Rated (30). QIDS-C, 16-item Quick Inventory of Depressive Symptomatology—Clinician-Rated (29). QIDS-SR, 16-item Quick Inventory of Depressive Symptomatology—Self-Report (29).
Baseline Axis I and III Disorders of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
c From the Psychiatric Diagnostic Screening Questionnaire (25).
d From the Self-Administered Comorbidity Questionnaire (26).
During the first 12 weeks, the participants were in treatment for an average of 10 weeks (Table 4). Of the 665 participants, 86.0% (N=572) completed at least 4 weeks of treatment. Overall, 78.3% (N=521) completed week 8 and 72.2% (N=480) completed at least 12 weeks of treatment. For the escitalopram-placebo group, the escitalopram dose was close to the maximum target dose of 20 mg/day. For bupropion-escitalopram, the comparable mean exit escitalopram dose during acute treatment was significantly lower, at 12.5 mg/day (SD=8.3) (χ2=31.15, df=1, p<0.0001). Also of note, while the venlafaxine dose was close to 200 mg/day by 12 weeks, the mean mirtazapine dose was only 20.0 mg/day (SD=15.7) (Table 4).
Treatment Characteristics at 12 Weeks and 7 Months of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
b Medications listed first are referred to as "open," while those listed second are referred to as "blinded."
c Chi-square analysis for categorical data and t tests for continuous data.
d For the subgroup receiving escitalopram plus placebo, the unit of measurement is pills.
As shown in Table 5 and Figure 2, the treatment groups did not differ in either remission or response rates, nor did they differ in the percentage of change in QIDS-SR score (baseline to exit or 12 weeks) or in effects on quality of life. The venlafaxine-mirtazapine combination was associated with more side effect burden than escitalopram-placebo. Patients taking venlafaxine-mirtazapine had more adverse symptoms (ear aches, blurred vision, irritability, etc.) present at baseline that became worse during treatment, as measured by the Systematic Assessment for Treatment Emergent Events (mean number of effects=5.7, SD=5.8), than the monotherapy group (Table 5).
Outcomes at 12 Weeks and 7 Months of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
a For some variables, data were not available for all subjects. IDS-C, 30-item Inventory of Depressive Symptomatology—Clinician-Rated (30). QIDS-SR, 16-item Quick Inventory of Depressive Symptomatology—Self-Report (29).
c Defined as at least one of the last two consecutive QIDS-SR scores ≤5 and the other ≤7.
d From the Frequency, Intensity, and Burden of Side Effects Rating Scale (31).
e Significantly different from monotherapy.
f From the Systematic Assessment for Treatment Emergent Effects—Systematic Inquiry (38).
Rates of Remission and Response for Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinationsa
a Remission was defined as scores of less than 8 and less than 6 on the 16-item Quick Inventory of Depressive Symptomatology—Self-Report (QIDS-SR) (29) at the last two consecutive assessments. Response was defined as a reduction of at least 50% in QIDS-SR score.
Overall, while 72.2% of the 665 participants (N=480) completed at least 12 weeks of treatment, 65.6% completed 16 weeks or more, 61.4% completed 20 weeks, 55.6% completed 24 weeks, and 58.0% completed 28 weeks. Attrition rates over the 7-month period did not differ among treatment groups. Average drug doses were basically unchanged from 12 weeks to 7 months of treatment, regardless of treatment group (Table 4).
At 7 months (or study exit, if earlier), the three groups were not different in terms of remission rate (range: 41.8%—46.6%), response rate (range: 57.4%—59.4%), or attrition rate. Nor did the groups differ in the percentage of change in QIDS-SR (baseline to exit or 7 months), quality of life, or work and social adjustment.
Table 6 compares the side effect frequency, intensity, and burden in the escitalopram monotherapy group and each of the combination groups. Overall, there were modestly more side effects with escitalopram-bupropion than with escitalopram-placebo in both the 12-week and 7-month comparisons. On the other hand, the venlafaxine-mirtazapine group had greater side effect frequency and intensity at 12 weeks and greater side effect frequency, intensity, and burden at 7 months as compared to escitalopram-placebo.
Odds Ratios and Beta Coefficients From Regression Models of Outcomes at 12 Weeks and 7 Months of Depressed Patients in a Comparison of Antidepressant Monotherapy With Two Antidepressant Combinations
a IDS-C, 30-item Inventory of Depressive Symptomatology—Clinician-Rated (30). QIDS-C, 16-item Quick Inventory of Depressive Symptomatology—Clinician-Rated (29). QIDS-SR, 16-item Quick Inventory of Depressive Symptomatology—Self-Report (29).
b Adjusted for regional center, employment, and anxious features.
c Adjusted for regional center, sex, baseline score on IDS-C, and baseline score on Work and Social Adjustment Scale.
e Significant odds (categorical measures) or beta (continuous measures) for the combination.
f Adjusted models are unestimable.
g An extremely nonnormal distribution required binning.
h From the Systematic Assessment for Treatment Emergent Events—Systematic Inquiry (38).
The study has four key findings: 1) remission and response rates were not different at 12 weeks, 2) remission and response rates were not different at 7 months, 3) the effects of the three treatments on quality of life and on work and social adjustment were not different, and 4) extended-release venlafaxine plus mirtazapine was associated with a greater side effect burden at 12 weeks and 7 months than escitalopram plus placebo and a higher number of worsening adverse events than escitalopram plus placebo at 7 months. We found no clinical advantage over escitalopram-placebo from either combination of antidepressant medications in terms of either remission or response rates at either 12 weeks or 7 months. The remission rates approximated those expected on the basis of monotherapy studies of chronic depression (5, 6). Both combination treatments had more side effects (in terms of frequency, intensity, or burden) than escitalopram-placebo in both the acute and continuation phases. Attrition rates, however, were not different across the three treatment groups in either phase of treatment. The venlafaxine-mirtazapine group was at particularly greater risk for side effects. In fact, it had significantly greater worsening of side effects than escitalopram-placebo despite the fact that the mirtazapine dose was not high (about 20 mg/day).
Prior reports have suggested that the response to either medication combination would exceed the effects of monotherapy. An open study of 49 patients (41) given escitalopram (up to 40 mg/day) plus sustained-release bupropion (400—450 mg/day) found a 63% remission rate at week 8. Blier et al. (18) compared mirtazapine, paroxetine, and the combination in a 6-week double-blind, randomized, controlled trial conducted at two research clinics with clinically referred patients and symptomatic volunteers (N=61). Remission rates at 6 weeks were 19% for mirtazapine, 26% for paroxetine, and 43% for the combination. Most of these patients had melancholic symptom features and either had nonrecurrent depression or had an index episode lasting less than 1 year. Drug doses included up to 45 mg/day of mirtazapine and paroxetine amounts that could exceed 30 mg/day (average final or exit doses not reported).
In a recent, larger 6-week double-blind acute randomized, controlled trial, Blier et al. (13) compared fluoxetine (20 mg/day) with mirtazapine (30 mg/day) in combination with fluoxetine (20 mg/day), extended-release venlafaxine (225 mg/day), or sustained-release bupropion (150 mg/day). Each combination had a remission rate (46%—58%) that exceeded that of fluoxetine alone (25%). In the study, 76% of the participants met melancholia criteria, 63% had recurrent major depression, and 61% had an index episode longer than 1 year. It is interesting that the response rates were not significantly different (54% for fluoxetine, 68% for mirtazapine-fluoxetine, 73% for mirtazapine-venlafaxine, 65% for mirtazapine-bupropion). Of note, this 6-week study may have been too brief to allow the full benefit of fluoxetine to be expressed (42).
There are several other possible explanations for why our findings differ from those of Blier et al. (13). The studies differ in terms of length of treatment, primary outcome, and scales used to assess outcomes. Our results are not accounted for by either differential attrition across the three treatments or baseline differences. On the other hand, our participants differed from those studied by Blier et al. Neither participant group was treatment resistant. However, participants in our study were required to have chronic and/or recurrent depression. In fact, there were far more chronically ill participants in our study than in the one by Blier et al. In addition, 62%—85% of their participants had melancholic features (compared to only 20% in this study). Some reports (17, 43) suggest better efficacy, i.e., drug-placebo differences, for inpatients (who are more likely to have melancholic features) with combination medications or dual-action medications. In addition, a meta-analysis by Perry (44) revealed that broader-action agents (e.g., tricyclic antidepressants) have far greater efficacy than SSRIs in melancholic depression.
To evaluate the potential impact of chronicity on outcome, we reanalyzed the data. Chronicity was associated with lower remission rates across all three treatment cells. Specifically, in the bupropion-escitalopram group, 37.2% of the patients with episodes of chronic depression had remissions, whereas the remission rate was 41.0% for nonchronic depression. Analogous rates were 35.5% versus 43.1% for escitalopram-placebo and 34.9% versus 41.9% for venlafaxine-mirtazapine. We conducted a similar analysis to compare patients with and without melancholic features from the current study. Melancholic features were associated with more axis I comorbidity, greater symptom severity, and more suicidal plans and thoughts. However, remission rates ranged from 30.0% to 39.1% for those with melancholic features and from 37.5% to 39.5% for those without. There were no differences across medication groups. Thus, neither the difference in the proportion with chronic illness nor the difference in melancholia seems to account for why our results differ from those of Blier et al. (13). While we enrolled the kinds of patients (i.e., those with chronic or recurrent depression) for whom most clinicians would be likely to consider antidepressant medication combinations (45), we cannot rule out potential impact on outcomes from one or more unknown baseline features.
This group with chronic and/or recurrent depression had high rates of self-reported emotional, sexual, or physical abuse before age 18, and a high proportion had anxious features. While these features could have reduced the overall benefit of any one treatment, they would be unlikely to obscure differences between treatment cells, given their proportional distribution across the cells.
Perhaps the differences between the present study and the results reported by Blier et al. (13) are due to the specific antidepressant medications and doses that we used and to the doses that were administered. There is evidence for the efficacy of venlafaxine plus mirtazapine (13, 35) and bupropion plus escitalopram (16, 34). Carpenter et al. (46) found that mirtazapine, when used as an adjunct to previously ineffective SSRIs alone, was more effective than placebo in treating depression. In fact, Blier et al. (13) used the venlafaxine-mirtazapine combination and Stewart et al. (41) used bupropion plus escitalopram in their trials, although the doses were higher in both of them. The rationale for a higher venlafaxine dose is that the effect on the norepinephrine system (17, 47) is only realized at doses of at least 225 mg/day. Mirtazapine has antagonistic effects that are modest at 15 mg/day and more clearly evident at 30 mg/day. Thus, as suggested by Blier (personal communication), the doses in CO-MED may have been insufficient in a large enough proportion of participants to preclude the benefit otherwise available from the combination. In an attempt to evaluate that notion, we identified the 86 participants who reached 225 mg/day of venlafaxine and 30 mg/day of mirtazapine at any time during treatment. Their remission rate was 33.7% at 12 weeks and 41.9% at 7 months. These results do not suggest that underdosing was the cause of the poor performance of this combination.
It remains an unanswered question whether these larger doses (if they are required to achieve an advantage for antidepressant combinations) are achievable in practice with more representative patients who have chronic and/or recurrent major depressive disorder and more concurrent axis I and III disorders.
This study had several limitations. While larger than many studies, the study group may not be representative of the universe of outpatients with chronic and/or recurrent major depression. As noted, the doses used may not have been sufficient to realize the full potential value of combination antidepressant medications. The results for the continuation treatment phase are limited by the fact that the subjects were not rerandomized or stratified by level of improvement following the acute phase. Finally, the clinicians were not blind to treatment, and a structured interview was not used to establish axis I diagnoses.
In summary, in outpatients with chronic and/or recurrent major depressive disorder, there appears to be no advantage to either medication combination over escitalopram alone as a first-step treatment for nonresistant depression. Some combinations may incur a risk of higher side effect burden. This conclusion is conditioned on the doses employed.
The authors thank the clinical staff at each clinical site for their assistance with this project; all of the study participants; Eric Nestler, M.D., Ph.D., and Carol A. Tamminga, M.D., for administrative support; and Jon Kilner, M.S., M.A., for editorial support.


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Full Description
Craftsmanship and Guarantee
All of our handmade packs and bags are built to last in Duluth, Minnesota, USA. Our factory, where we have been building our products since 1911, is home to an extremely talented group of sewers, riveters, and leather craftspeople. Each piece of Duluth Pack gear is painstakingly built by hand with the attention and detail that only a true artisan can provide. We stand behind our work and are proud to offer a lifetime warranty covering all craftsmanship and hardware we use in the construction of our products. Craftsmanship includes our sewing and riveting. Hardware includes all zippers, buckles, D-rings, snaps, and any other parts utilized in the manufacturing of our bags. If at anytime during the life of your Duluth Pack product you have problems in these areas, return the product and it will be repaired free of charge. If the product cannot be repaired due to a defect in craftsmanship or faulty hardware, we will be happy to replace the item at Duluth Pack's discretion. While your Duluth Pack item is designed to provide you with many years of use, Duluth Pack is not responsible for common wear and tear or misuse of your product and is therefore not covered by our warranty. Of course, damages not covered under warranty can usually be repaired at a minimal cost. We sincerely value your patronage and will always do our absolute best to go the extra mile to ensure that you are happy with every Duluth Pack purchase.
Customer Reviews
Items 1 to 10 of 12 total
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- 2
- antique iceboating
- Rating
Sometimes 40 knots over the deck of my antique iceboat. The anorak laughs at this. I do need to add a toggle to the bottom to keep it from blowing up.
Posted on 3/28/2014 by ben
- 20 year old anorak
- Rating
im writeing my review 20 years later the anorak has been on most of my winter hunts and has never failed to do what its sappose to do it kept me warm in -20 with winds blowing i didnt know at the time of purchase what to think but after all these years it was the right choice very tough requires less clothig under neath and freedom of movement thanks for such great winter clothing
Posted on 12/29/2013 by keith
- Rating
Posted on 6/19/2013 by timothy
- Awesome
- Rating
I just received this Friday, we had a blizzard that night. Next day I put it over my fleece and it performed awesome. It wind blocked winds of 25-35. The blowing snow melted in droplets which just dropped off. I'm wearing this to bed. Oh, I' 5'8', weight 140, wore a size medium and had plenty of room to spare.
Posted on 2/9/2013 by BassLass
- Great for winter biking!
- Rating
I've been using this anorak when it is below 0 celsius to ride around the city. I can't get over how little I need underneath to stay warm. I no longer need to dress like the Michelin man. It does such a great job of blocking the wind, your wool or insulation layer seems to hold all your body heat in.
Posted on 12/26/2012 by Steve
- Versatile winter wear
- Rating
I live in the Arrowhead country of Minnesota and also in Northwest Ontario. I spend many days each winter winter camping and ice fishing. I bought a Duluth Pack Anorak this year. It s easy to find clothing that will keep you warm at one temperature. However, when you are pulling a heavy sled through deep snow in cold and wind you get over heated and then when you stop you get cold. This anorak kept me warm and comfortable in all conditions. If I started to get too warm I dropped the hood, if cold I put up the hood. I spent many hours on the ice in subzero weather and stayed warm and comfortable all the time. What a great product. I would recommend to anyone who intends to spend a lot of time outdoors in northern Minnesota or Canada.
Posted on 2/5/2012 by northshore218
- Well Crafted Work of Art
- Rating
I am an avid hiker/camper. My Anorak is with me at all times. It is just as at home down south in a Georgia swamp as it seems to behind a dog sled. The construction is second to none. Garments of this quality are hard to find and once you put it on you feel as if you can explore your wildest dreams with ease. Well worth the price for admission.
Posted on 12/18/2011 by Mud
- good product
- Rating
Wore to 2 day dog sled school in MI upper penn. Broke wind while breathing well, was very comfortable, this anorak is the real thing
Posted on 1/9/2011 by nomind
- Anorak
- Rating
I have had my anorak forever, and I sure enjoy wearing it over my parka, I go ice fishing. I recommend it to anyone who goes out hunting, fishing and hiking.
Posted on 1/7/2011 by Naqucin
- Love this!
- Rating
I am not an outdoor fisherman or camper or explorer, I'm just an average kind of girl who loved the style of this anorak. I wear it all the time to things like the farmers market in the fall and winter, shoveling the sidewalk and just playing outside in the fall and winter. Many times I add the wool pullover that matches it. The only thing I wish was different is that it is a bit stiff for quite a while. I love my anorak!
Posted on 7/17/2010 by larnimi
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subset: commoncrawl


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Prices and availability are subject to change from the time and date that you print this page.
10/26/2014 5:42:45 AM. For Customer Service, please call 800.606.6252
Pickup Check store pickup options
construction zone. Inspired by the angled iron of construction beams, handcrafted seat squares up in steel with raw zinc finish. Continuous bent-steel legs angle back support at just the right pitch. Sits indoors or out.
Details and Dimensions
industry chair. 19.5"Wx16"Dx31"H
- Handcrafted steel with raw zinc finish
- Protective rubber foot pads included
- Indoor and sheltered outdoor use; bring inside during inclement weather
- Made in India
Overall DimensionsWidth: 19.5" Depth: 16" Height: 31" SeatWidth: 16" Depth: 16" Height: 18.25"
- For outdoor use.
- Will develop a natural patina over time.
- For soil build-up, wipe with damp cloth & dry.
- Do not use abrasive cleaner.
Return/Exchange Policy
The short story is that you have 90 days within receipt of your purchase to make a return on most non-furniture items. For furniture returns or exchanges, please call us within 7 days of receipt at 800.606.6252 so we can advise you on how to make your return within 90 days of receipt. Notably, for Special Order upholstery items, returns and exchanges are limited to transit damage or manufacturing defect. Our policy is simple. If you are not satisfied with your purchase, we promise an appropriate refund, credit or exchange.


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Chakra Print Yoga Mat (3mm)
Non-slip Chakra mat with a pattern representative of the body's seven energy centers
Feel grounded in your yoga or meditation practice with our stable, non-slip Chakra Mat. Representing the seven energy centers that run from the base of your spine to the crown of your head, our one-of-a-kind colorful mat is a helpful reminder to keep your mind, body and spirit in alignment. Extremely durable with a light-tack surface. Perfect for home or studio use. Manufactured free of the top six most harmful phthalates, this mat is a healthier choice for both you and the planet!
Chakra Print Yoga Mat Features:
- Light tack non-slip surface
- Lightweight and durable
Need help finding your perfect mat? Use our Yoga Mat Finder tool.
Each mat comes with our Lifetime Mat Guarantee and a FREE yoga practice video download code.
68"L x 24"W x 3mm
Latex Free
6P Free: Free of DEHP, DBP, BBP, DINP, DIDP, and DNOP phthalates.
Printed yoga mats release a very strong but harmless odor when first unwrapped. Please unroll and air out your mat for 2-3 days before use. Spot clean with our Yoga Mat Wash or damp cloth with cold water and mild detergent. Dry flat. The mat may fade and become brittle and unusable if exposed to the sun for extended periods of time. Store in a mat bag when not in use.


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November 28, 2012
Up Close
The comedienne launches her talk show Love You, Mean It with the "smartest b–– in the game"
Happy Birthday, Ryan Reynolds! See His Changing Looks
Go Inside Florida Georgia Line's Brian Kelley's Tennessee Treehouse
60 Seconds, 15 Style Questions with Olivia Palermo
Why You're Gonna Want to Stay Away from Josh, Fergie and Axl on Halloween
See All
Oct 23, 2014
Meet Your New Crush, Constantine's Matt Ryan
Watch It
Oct 21, 2014
Oct 20, 2014
Warning, Ladies: If You Give These to Omar Epps, He'll Throw Them Out
Oct 22, 2014
Amy Poehler Tells a Crazy Story from the Parks and Recreation Set – but Is It True?
Oct 19, 2014
Meet The Walking Dead's Hilarious Josh McDermitt
Oct 17, 2014
Cary Elwes Reveals Behind-the-Scenes Secrets From The Princess Bride
Sep 25, 2014
Celebrate Michael Douglas's 70th with These Memorable Movie Moments
Sep 17, 2014
Remix! You've Never Heard Sheldon's 'Bazinga' Like This Before
Sep 04, 2014
Make 'Em Laugh: Joan Rivers'sBest Lines
Oct 24, 2014
Go Crazy for Kip Moore's 'Crazy One More Time'
Nikki Yanofsky Has Some Serious Pipes!
Oct 18, 2014
Hear Seven Handle Circus Jam on 'And We Danced'
Oct 16, 2014
Oct 01, 2014
The Women of Scandal Reveal Their Own Style Scandals
Sep 19, 2014
Check Out PEOPLE Stylewatch's Denim Party Confessional
Florida Georgia Line's Tyler Hubbard Had What Built Into His Bedroom?!
Oct 07, 2014
Which Pretty Little Liars Star Converted an Extra Bedroom into a Dream Closet?
Sep 29, 2014
Tony Dovolani: My First Name Isn't Actually Tony
Sep 06, 2014
Kermit's Guilty Pleasure Is Ham?! What Would Miss Piggy Think?
Aug 27, 2014
What Is Mark-Paul Gosselaar's Middle Name?
Meet the Iowa Family Members Losing Their Vision Due to a Rare Disease
Jun 28, 2014
VIDEO: Does the Texas Youth Football Association Go Too Far?
May 30, 2014
2 Minutes of Glam: Behind the Scenes at Cannes
Elisabeth Moss: 'The Worst Person I Ever Met Was …'
Where Were All of Hollywood's Hottest New Stars Last Night?
The Cutest 2 Minutes Ever: Prince George's First Year in Review
Can Brad Paisley Pour the Perfect Pint Guinness?
Watch What Happens When a Kangaroo Holds Court at the PEOPLE Offices
Country Star Josh Turner: The Time My Sons Thought I Was Cool
People Top 5
Kate Dazzles During Glam Night Out
Read It
Kate Makes Her Royal Comeback – in a Carriage!
Princess Kate Wows Again at Charity Gala
How Princess Kate Got Back to Her 'Smiling, Bubbly Self'
Tom Brady's New UGG Commercial Features His Dog ... Is It Rude to Stare?
Copyright © 2014 Time Inc. All rights reserved. Reproduction in whole or in part without permission is prohibited.


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Main Content
You're all about lookin' good, on and off the court. You have no problem showboating your ankle-breaking crossovers and jaw-dropping dunks on the court. Off the hardwood, your polished LA Clippers gear keeps you stylish and proves your fanaticism. Keep your baller status going strong when you support the Clippers and Chris Paul in this Chase replica jersey by adidas. This hip fashion jersey features "Los Angeles" printed across the front with Paul's name and number on the back and adidas' signature stripes running down the sides. With you on the Clippers side, the rest of the NBA better be ready for all the nonstop action of pure greatness that you and this jersey will bring to LA.
- 100% Polyester fabric
- Applied stripes
- Imported
- Jock tag
- Officially licensed Clippers jersey
- Screen print graphics
- Tagless collar
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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On a Fairly More Personal Note: Confessons Part 1
Here are confessions! Now if you want your confessions in one then send them to this email address:
……. email@example.com ……..
I promise to leave your name out because these are anonymous
Also if you would like to see these continue I recommend you tell me so. So far I haven't been getting a lot of feedback on my notes. So you must comment and tell me. If I don't get alot of demand for this then I will discontinue this. Its all for you folks. :) I will be posting another one as soon as I get enough confessions, so send me a message with confessions 2 in the title and it will make me happy. :) Also I put one of my own confessions in here but please don't try to guess anyone's. Kay?
*I'm determined to become Lady Gaga's best friend :)
*I wish I had a pair of antenna, not like attached to me, but you know those cute headbands with bobbles on the tips or whatever, I want a sparkly pair that glow in the dark. I am pretty sure i would wear those everywhere.
*I dated a gay guy!
*I'm addicted to Degrassi:the next generation!
*I'm addicted to carmex… lol
*I am obsessed with sex & the city. I just started watching & literally can't get enough :)
*I'm obsessed with pixie sticks
*I don't like chocolate..
*I'm addicted to Canibus ;)
*I've always wanted to be a princess. My whole life I've been one of the guys, but secretly I wanna wear dresses all the time and get my nails done. I've never tanned or anything. I just wanna be a girly girl!
* I count the steps I take while going down stairs lol
*I love Diet Dr. Pepper more than any other beverage.
*I'm really obsessed with Justin Bieber..
*I sleep with my computer on which gives light, because im afraid of all the spiders in my house.
*I seem to be unable to sit for very long without propping one leg up with the other, and then when that leg gets tired, I switch sides.
*I'm scared of elevators
[A big ginormous huge thank you to everyone who sent in confessions! They were all really good! Please send in some for next time too!
loves and kisses


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This gorgeous Pakistani Beauty came in Pakistani fashion Industry in the year 2000 and very soon reached at the peak of success and fame with her luscious looks and determination.
Latest Pakistani Women Wear 2010
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It wasn't your typical party venue in Chelsea last night as Chanel transformed a raw space into a Moulin Rouge–esque environment complete with painted backdrop, oversize N°5 and double-C logos, and waiters doling out coupes of champagne.
Scarlett Johansson (born November 22, 1984) is an American actress, model and singer.
Spring Summer 2015 Paris Fashion Week | Paris Fashion Week Spring Summer 2015
The first Sustainable fashion show on the official LFW catwalk schedule will showcase key looks from established and emerging designers working sustainably.
Dolce & Gabbana Spring/Summer 2015 Milan Fashion Week Collection, Milan Fashion Week Spring/Summer 2015 Collection by Dolce & Gabbana
Pendant lamps truly offer one of the best choices when it comes to lighting needs for your home.
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The organization presented award certificates and medals during the annual ceremony, during which a school representative would speak about the character of a student.
Genie Certain of DAR previously said students were chosen by teachers at their respective schools. Students who receive the good citizenship award often excel academically, but must show good leadership to their peers.
During the event, teachers, administrators and even parents spoke on behalf of the students.
"If you've been around Ishara for any period of time, you automatically pick up that she has
intrinsic motivation," Euharlee Elementary School fifth-grade teacher Karen Farr said of student Ishara Merine. "In other words, she always has the desire inside to always do her best, it doesn't matter what she's working on, ... and the best part is she does it all with a smile on her face."
Students recognized during the event also are involved in extra-curricular activities such as athletics and community service.
This year's Good Citizenship Award recipients are:
McKayla Cantrell of Adairsville Elementary
Jennifer Mendoza of Allatoona Elementary
Raven Waterman of Cartersville Elementary
Alexis Dunlap of Clear Creek Elementary
Sophia Gomez of Cloverleaf Elementary
Alexis Stone of Emerson Elementary
Ishara Merine of Euharlee Elementary
Bella Spencer of Excel Christian Academy
Riley Nelson of Hamilton Crossing
Ethan Stump of Kingston Elementary
Reece McCamy of Mission Road Elementary
Adam Hall of Pine Log Elementary
Michele Maserjian of Taylorsville Elementary
Atisham Ajma of White Elementary
Inga Megee of Adairsville Middle
Maggie Dent of Cartersville Middle
Madison Dunn of Cass Middle
Zara Rainey of Excel Christian Academy
Arlene Cornejo of South Central Middle
Amelia Payne of Woodland Middle


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Alerts and Important Information
- Dirt area will accommodate 1 12x12 tent.
- Full hook-up site.
- Covered table for shade.
- Views of Sand Mountain and Pine Mountain.
Find your site
Sand Hollow State Park, UT
Status: Open year round. Season Dates
Max reservation window: Sun Feb 22 2015
Site, Loop:WS15, WEST
Find Similar Sites Type:STANDARD-FULL HOOKUP Amenities:
Please enter arrival date
Site Details:
Alerts and Important Information
Footnotes: (applicable only where specifically marked above)
** Arrival dates earlier than the online-reservation-window may also be available at the campground.


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Would you like to save names or email namesto a friend?
Sign up here.
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First name content excerpted from The Complete Idiot's Guide to 30,000 Baby Names © 2005 by
Marcia Layton Turner.
this book online or call 1-800-253-6476.
Last name content copyright © 2006 Patrick Hanks.
Name origin: English
Name meaning: metonymic occupational name for a huntsman, or rather
a nickname for an exceptionally skilled huntsman, from Middle English
chase 'hunt' (Old French chasse, from chasser 'to
hunt', Latin captare).
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A Closing, An Opening, a Political Poser, and Another Chance to Take Action
In her Easter Island–meets–Disney–de Kooning–and–Warhol portraits of Bugs Bunny, Donald Duck, Mickey Mouse, and others, Pensato combines the gesturalism of action painting, the painterliness of Abstract Expressionism, the blatancy of Pop, and the wild style of graffiti. Warhol gave us Double Elvis; Pensato paints a diabolical Double Mickey. De Kooning destroyed the female form to make his Woman paintings; Pensato destroys preconceptions of cuteness and innocence. An older woman is using Expressionistic male angst to make these buggy subjects while pointing out a disturbing racism inherent in many of our most loved cartoon characters.What are you waiting for? Go see this show!
If you're in Boston, however, don't miss "Traveling without Moving," the exhibition of fabulous new paintings by my dear friend Amanda Church, opening tonight at the newly launched Julie Chae gallery.
450 Harrison AvenueIn this new series of what Ken Johnson, then writing for the Boston Globe, recently termed "vibrant Pop-style abstractions," Miss Amanda takes her uber-cool palette of psycho-sexual canvases to locales muy tropical like Miami, Puerto Rico and (OK, so it's nice in the summer) Eastern Long Island. Again, Run, don't walk, to go drink in this gorgeous show!
Storefront 47 Thayer St.
Boston, Mass 02118
I had a nice chat at the opening of a fellow gallerist's space last night about what to expect should the GOP retain the White House or a Democrat win in November. His take was that either Hillary or Obama winning would send shivers down the spines of collectors. Fearing that their disposable income would be taking a tax hit, they'd pull back on art buying. If McCain wins (none of the others is even remotely acceptable, so let's limit our speculation to one possibility here, shall we?), he may not extend Bush's tax cuts without deep cuts in spending, but he'll be inclined to support the notion that it's better to let the wealthy keep as much of their money as possible. My colleague pointed out, however, that Hillary or Obama are more likely to support Federal funding of the arts, and that while this may not be great for the market, it might be good for Art itself. So it depends on your priorities. I, of course, want the best of both (more arts funding, at least for nonprofit spaces that take chances on under-represented artists) AND a strong confidence among collectors that they can keep supporting the arts on a personal level. I'll be pulling the lever for a Democrat come Tuesday, but I'm still not sure which one. I'm leaning toward Obama, but, being strongly of the opinion that people should mostly vote their own self-interests, I'm willing to listen to others' opinions on who's best for art's future.
Finally, the deadline for you to take action in protecting Spiral Jetty has been extended. Tyler explains:
Don't almost do something here! Take Action Today! Here, I'll make it easier for you [from Tyler]:
This just in from the Utah governor's office: The comment period about the Spiral Jetty-impacting energy development has been extended to Feb. 13. For more information from the state of Utah, click here. For more information on how to comment, click here.
UPDATE: The Seattle P-I's Regina Hackett says that the state of Utah has already received 1,000 comments, and that those comments have alerted them to the importance of the Jetty. "I think they were impressed to be taking calls from Europe and Japan about an artwork in Utah," the acting director of the Salt Lake City Art Center, Leslie Peterson, told Hackett.
If you want to send a letter of protest to save the beautiful, natural Utah environment around the Spiral Jetty from oil drilling, the emails or calls of protest go to Jonathan Jemming 801-537-9023 firstname.lastname@example.com. Please refer to Application # 8853. Every letter makes a big difference, they do take a lot of notice and know that publicity may follow. Since the Spiral Jetty has global significance, emails from foreign countries would be of special value.
Labels: art exhibitions, politics


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sorry I'll take -35Originally Posted by Brad
sorry I'll take -35Originally Posted by Brad
i am a Summit Club member
http://public.fotki.com/hvachawk/new pictures and videos
If your not a OBS member yet then what are you waiting for
Good - I would not want to fight you for the grand prize.Originally Posted by hawk
Brad (a 6288 club member)
http://bradstreet.zenfolio.com Personal Photo sales site
http://public.fotki.com/bradbradstreet Personal photo web site
http://public.fotki.com/MWO/saved/2012/ MWO image & video archive site 2006-2012
I asked my magic 8 ball, it advises -29 on 02/31-It's not that accurate so I will take the date of 02/14.
It's Smarter to be Lucky, then it's Lucky to be Smart
Are you a Minion?
If that happened, you should win a years stay on the mountain if that happenedOriginally Posted by tkahike
Dave Johnson
It was revealed to me by the Medeoulin caretaker of the Oracle of the Abenaki that the lowest temperature for the month of February 2007 will be
-31 deg F.
Veni, Vidi, Velcro!
OK I wanna play this month, too.
My guess is -44 on the 4th of February.
Wow I just looked at you gallery for the first time. You have some awesome shots in there! OMG is that 3rd to the last pic on page one a sign with that much rime on it!!! or is it something else?The contestant who is closest will win one framed 8"x10" photo from my Mount Washington Gallery.
It's the smoke stack on top of Tip Top House, about the same size as a sign you'd find in the White Mountains. But you can't win it if you don't put down a guess....and a date.Originally Posted by Cliff
Next up: Vermont City Marathon: May, 2011
-28 degrees
Last edited by whitemtnvisitor; 01-25-2007 at 10:20 PM.
I think we all can pick the same temp Brad ...just so long as we pick a differnt tie breaker (date of temp) ? Ill go -28 feb 28Originally Posted by Brad
eric j


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From the forthcoming film by Bill Hayward, Asphalt, Muscle and Bone, about a man at risk, the persistence of imagination and the impossibility of love. Produced by Bill Hayward and Anna Elman.
See more of Bill Hayward's work here.
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I left it
on when I
left the house
for the pleasure
of coming back
ten hours later
to the greatness
of Teddy Wilson
"After You've Gone"
on the piano
in the corner
of the bedroom
as I enter
in the dark
from New and Selected Poems by David Lehman
by T.P.Winch
Ringfinger was nervous
Pinky terrified
when they learned
that Hand might succumb
to the rule of Thumb.
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Making his debut at Penske Racing, Joey Logano will drive the No. 22 Shell Pennzoil Ford Fusion in the NASCAR Sprint Cup Series™ in 2013. After a successful 2012 season, Logano is switching gears and making a dash to the finish line in the popular yellow-and-red paint scheme.
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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You do it your way, just like Matt Archbold. Give a nod to a mind-blowing surfer while standing out from the crowd in the Archy boardshorts from RVCA. These 4-way stretch boardshorts feature a water-repellent treatment, an allover camo print and a tie front. You were built for speed, and born to surf.
- 11.5" Inseam
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RVCA Customers also liked:
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


text:
BMC Racing Team Assistant Director Rik Verbrugghe said a longer, harder circuit for Sunday's edition of GP Ouest-France should suit the team's aggressive roster for the one-day race in Plouay.
Van Avermaet's Aggressive Approach
The new course for the 243-kilometer circuit race has been lengthened to 27 kilometers and each of the nine laps will feature three climbs. "It appears to be a little bit harder than in the past," Verbrugghe said. "There's a new climb that's more like gravel and I understand it's quite steep." Verbrugghe said the BMC Racing Team will play the role of aggressor like it did at the Vattenfall Cyclassics last week. One of the riders he will look to is Greg Van Avermaet, who said he hopes to continue the form he enjoyed at Vattenfall when he put in several attacks in the second half of the race. "My legs have been feeling good the last couple of weeks and this is a race that suits me," Van Avermaet said. "I will try to do something in the race to go with a small group to the finish."
BMC Racing Team GP Ouest-France Roster (August 26):
Adam Blythe (GBR), Marcus Burghardt (GER), Martin Kohler (SUI), Marco Pinotti (ITA), Manuel Quinziato (FRA), Greg Van Avermaet (BEL), Danilo Wyss (SUI).
Dario Spinelli (ITA)
Press Officer:
Blandine Roquelet (FRA)
Bus Driver/Soigneur: Gunther Landrie (BEL). Mechanic: Jürgen Landrie (BEL). Soigneurs: Bernd Coutteau (BEL), Freddy Viaene (BEL).


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Send them a soothing get well gift they will really appreciate. The Source Vérité Sheer Vanilla Spa Basket is a gift that surrounds the body in an intoxicating essence that?s exotic, delicate and thoroughly relaxing. Madagascar vanilla, sultry amber and notes of warm sandal and cedar woods infuse an invigorating shower gel, refreshing sugar body scrub, hydrating body butter and other gifts included in this comforting Spa collection. Our lotions and gels are made exclusively in the U.S.A.
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A sober and atypically flawed NYC resident who practices and teaches Muay Thai, loves art & can be found recklessly riding a bicycle w/a camera in 1 hand & cell phone in the other. Expect to see NYC from my view point, vintage and or muscle cars, street art, random architecture and interesting bicycles. Brought to you by Brent A Bartley.
Stuff I like
- Photo via themuaythaiguyPhoto via themuaythaiguy


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1887-04-01; Clare Democrat
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Fi'olmte "D©**a*t"t isa sessloa &£ Haggisoaa tlie «J>3Se© in new B©sl3iMrelI©-TO' M©©^, £31a"r©p F"J Ussr- Tf It OAMBMET^S., H* D.f ■Qi n PHTMOIAWy SHIS6-2S0-H' i*OS» A€*COI3t*SS*iiJ*S. rra X ?0»BS M. »., ' " A.*- JJ? a PII^SIKHAK, SUKGSSCM AS*© A€f-*®*0C"H*BlJ-2* ©iradtigsteof the WBiTfgi-sity ©f 2Si©liig£a*u Z52I ealla isroinpflyalt-^iitsteti t© Say mz * -aagirt. ©Mse ©ver BMea's stows,, "■^gis^r tomofjro^-. *JM§"fei&Afif©G&"day7'l, - ' Higgs, M eeiifcs jpsr -io-sen,' "Better-, 80 ceats pssr gonad, Fotatoes3 €§■ cente per BiislieL. 2Baste Is- one week-frosa aest Beimo^atl'e ^aiseHs Ssterday afterfloom. John Cmmex? ot Mwnmn, wss ia town Wednesday. Bairid Honeywell, ot Mt. "Fleasaat^was in towp Monday^ S, J, BeHfoe, the groc©r3 Is Md up thfe ■week with a lame teek» Me. Had Mis. M. S. Cooley w*sr® -visit- lag in H-mtIsos tMs w©e&- Hose Compa-ay ]fo»Swill gl¥e adfincc tMs eYeaiog at the <3" A, B, MIL Tho -resent snow storm and thaw lias made the foads ostpemely nmddy. "D.Ho Alwaard i?eterlied from "Lansing Tuesday; Me will -retton nes± "week, Ojit loeai snaikefe have advanced fee price on steaks from 12*^ to 15 cents per E. L. UaiT rts.iii Harg^ Mottday* on business,. . '-■•*■ Andy Alclrich^ of Kai1«fin. 74^ited. in town oyer Sunday. ; %m ■Regular meeting of ibe JtHai;e <*Otincil next Wednesday, evening **ji "Miss CSertoade >2i*B*^A i* vmiting friends in the Saginawt- %^v'i L'^- ,W. G. "Rnc"knia%. o£ $"§&*.»*.£,. Minn,, } was in town-this week *h ^issIjtvss.. .' School reports, for i'ufc /»n*nfh ending "March Ssfh, will he puMiVifif iiaxtweek. Indlcatioji are thafe n \svm time will he ha'd'-bver election' iii-l^ fiexfc* Monday; ■'.,;". " -!/ #ffie<3©22,S'*'lf'£li."sfeB^t-j.eas4 m Maim s&s&et. *n*T XjLOSfISies -■: ikiiio - *M2A€l,I<tlA15»-J>B"5r^li3,£.- .All worlk^iia-ra-Mt«©C. OSS^j© ©"TKiirBTaiiaio-p's f "rAIKSHSIgS^ JMLo " . wAiMnsnj,' . Mo-osm"*-* "Slgsa S25i€ Gsyfia^s *pi&2.t*mi_ ^•^asa-pTOgs Sjg^eisSSy*. All <amess 1)tqseij>1"1j £2S£i&"J5fieat©. f (SoagSaf ^n> wj£Am£H&E!s so WUtfoSSAtim®, FB'SECrO FAH-fSSjej, r "SmESslsiiiig -saxd JSigk WM.%i3sg. All ©srd^ss ' . Sill^SISIuSs^'SCliS'®"^©., ~M<®f$!£y JftiMa'e sjafi -Se"a©a?al; "Sbm, Floyd Fosts; <K£-,*Oolemaa, was a sailer at the BESt©CMA*l* oltce yesterday" aftemoo-s^ Hesf ly all the oatogs are broke op and tho asea are ooaii^: down to enjoy ci¥il- ixsMon once naore. "Mr^ Browny of Bro*wn City3 this state, [is thegiiest ©1 Ms daughter, *fiSxs.-Geo. 1*W* Smithy tlii's week, l A^ €* Bro^e lias- retnmed from. Meredith, w&ere he Md feeen visiting J^r a [eonplo or three weeks. Joha -and Joseph "Young wore' "Visiting thelTfpasenfemClaro lasfr' "week,, "jhey [ ha^e "fgeSairned to <eamp. Miss'' "Ella* Sa-wtell friencis mt Grand week; Mrs* Will-Harrison, ■ is the guest of Mrg. i1. f week. " ": Charley Bigley,spe*' Sunday with friends hi Sait River. The smiling cotmtena of Loomis,was seen o Saturday. ' Jas. A. Jay, of "MMluil ''looking after his husin on Monday .last. "■ *Mr.andMFS.'C. H. 0' Howard Ciiy.OTer Bundv, Today Is the finst of Apsil and newly | e3 Toesday evening, f • **.'*s'lj visiting iis^ flaring the *?s*"L Saginaw, ^'"-(Teries this. uutlay find I'lc-asant .and j of l#iv'.Grpss, street last ;itv*} %\?as- up terc&ts -Mere aid *wei4e in Theyjetorn- :e yon r^ ijvsr'ES'B, e*7efyls©dy will ©adeavor to m the' ^|^ of & ^©h^tn-at?5 MsM, W" W. "Film and children, of Mns- Is^goa, as*© the gtteste of Urs. S. H-. Be- ITogtj iii Osy% tMs weefe. A grass pi!**© weigliipg 2S pounds, 4?ap~ tor-ed fa Hdnghtoa iske, wasire&siYed hy H*. Blofesiell ©ia Wednesiclay* " * ; . It Is *©ir©dietecl tliat April will he a dull ^ ia»pS£«sad3Ki!d sBisgciei^ii^i fe©i^p I moa^a for freight fei»? ,©wpg the. mn- w-m j guttled steto of ft-ei^ht'i-ates. . - • JIM^V Bmz^ejost of €l^ss| - 5,&s»Ba¥li M4aeyw«H, of'-lM. Pleas- " A republican canons n^tlie tm^JisMp of (Grant is 'called for ^li/Mtftefiioon' at two o'clock, at the towii^*#% C. H. Sutherland- aii^ $**->*. JDolJeri*y. were in SagiBaw Hon oh biiisnes's cdnhectled If ■ y on, have} any thin j people'kno^.^t'throti^; It has -the largest- ci county.. ' :,; "- The. ^ehools wsi*^ in asafeo, v?83 'vimtl^ m i >t>wa this & wee7! &%** fehe I sii'flsv. "^"""'le A''hj"vt A i >*»*'.**■ J>ptUrtr--t 'iJc -iv*^. -».>^?» S,#'3-i**'©"SI-a3b J63S*3t"IS5 __iai edsIei!!tei^'eiI^L-fav0'l■l ©I tlse ^ae**idiE*a@i[itr ?23-elo2f stylo. ©|i)pssifels-s#3iaag©H©"5©i. f atth© M. JS. ehtir^ii m tffis wiiage ^»23]pEtS}sr JEffiDSaaJO-B," OsspsBSer aad fw B*o*ay*i«tf» CJaa-e. AH ^cir'&giS'S'-aiat^eaSiBt- c3sss aaiS: ipric€g.iFeas"3?aaM&-. IS* i^ili pay you ti®J3oIi<Jaa-Hae. " " ' 4-tf Tm H.©*b1TOG*J?» &hotogszspheiXr Bytliess© JLl^o -of tfao IsisSaiafeaaeo-sE-Bry*3F*Ifi*e, I S2a <32iaM*efi: to psodaee ea fis© w®clt im ^arls: as SagM w^atlaes*. Si?it yom* &wn. ©©2iv©nie"ace *tKBgssdle£,S£^-feieT/eatJs©2v Xota wSli -ftufi a Saarges* murl better Taanlety ©f accessories her® •2-Sia-a ia amy gallery ia Heartlie"En Mlentgaiu *B2*3; Ifletrares ©©ple€ an*i Sia3£a"ge&. Oi-ayon^ ^Pasfeeli. la-fiks lafe, Watssr an.fi Oil eolo-Tsr. £E&tt€iQ.©ireE' Gribesso-a9s store. bassm:. , 3233BE-X. "WM- "W-ESLSSY^ O. *H. S'JJ'iEEHSiaA-'aT®, HKJSMeTo ^L^ xU ^ W: id) IS). ft i"w»T» Eiaiga'Sj-ot Hlo. -"Fleasaistj dellf&v ind -,ri\$eMay, their fozielc wit let the 1H.MOURA.T, oi; iu the ia?t Sat- .child.- Geo. Calkins "was in East Saginaw Wednesday and Thursday.' Mrs. Mell Chamberlain, of Evart, was visiting in town this week. i} The drive on the Tobacco river was commenced last week. It will probably take a month or six weeks to run the logs all ont. J. W. Calkins will finish business at Harrison this week and return Saturday to live in Clare during th© summer,* ["Tip" will be welcomed. After April 4th (next Monday) conductors will shout -"-Tickets, please!" to editors and members of the legislature just as they do to ordinary people. There is an awful warning going the rounds of the press to the effect that a man in this state was recently struck blind while reading a borrowed newspaper. The Democrat office enjoyed a visit from postmaster C. j. Richardson, of Harrison, last Friday. He was one of the druggists in attendance to the pharmaceutical association. From present indications we may expect to'see a bevy of our town ladies at the poles, Monday, working for the prohibitory amendment. "Wont it be an unique and pleasant sight. Willie Parish is local agent for the best paper published in Michigan—The Detroit Free Press. Subscribe, have *it delivered to you daily, and get all the news. Price,-Only 12 cents per"week. *'*Bircls are piping up cheerily and practicing for spring*" says the Bay City Tribune.* Perhaps they are ih the Soutb, | but in this latitude the piping is not very soulinspiring, remarks the Saginaw Courier, ■ Jag, A. Warner, of*near Dover, returned last Friday after a two weeks' visit in the southern part of the state. He reports the frost out of the ground and (says farmers have commenced their spring plowing* A meeting oi the Dorcus Society of theM. E. church, of this -place, will be .held at Mrs." A, Loueh1s - next Tuesday Afternoon, at 2 o'clock, April 5th. All •are are invited to attend. __ . "' . 'M-es. CI li.WHlT-N^Y^Sec-y. Be-jn'eniber tbafc the 'Democrat office v*ht iw-p '6. lot of new job type*\ ■uk'Ciiilon day* '&> Miss IBira Reddest Is -home ®g$&n after a I few' weeM* absence- in the morthera -part of th© State, where she has been learning telegraph operating, Conms^ondents or the clerks of the several townships will greatly oblige us by sending election repoyta, Qiye the foil TOto for e&oh candidate. A severe snow storm, prevailed all day'J Monday,* and from 6 to 8 inches of snow fell. Sleighs and cutters were once more brought oat, hntthe "slipping disappeared The old warning: *Doo"*t fail to register this week Saturday if yon wish to cu-< Sagia&i?-- - SJeney 4© "Loan =021 ijnprcw-efl. real ©state at 1 03?easo-aaDi® xate of mterast, 49 m ii "S, !H ii 1 51 m '^OBSBSl*OHi*>-SWOl[r~F5*rst;"Sa"Momsl Bsafe of 1 vnfv, is^-Hh Wtmfiav ipmpmliw th^ a H-Bur Yorfe-i A«aerScam ^^hsmge "Hatioual vot*5 ^^ $&®nmy" .ittememoer, -suae a IBsisuls ef Befeeolt, fiaS cn^zens Ifetiossi Bsai£ registration for the village election does not perznii" you to vote on township matters. "Yoa mnst register for that also. Samuel "Yonag Is oonfined to the house this week from injnifies received in Pratt & HfiekarcPs camp last Tuesday, He was rolling logs onto a dray, when one of them started haek9- eatchiiag him and bnaising Ms hips and legs. :A couple of weeks ago the conncil refused to audit a bill of #5 for "keeping the wsalks clesr of sndw d-ariug the «r X' bs -"s g ^^ 3e§, *o , i!A%m& mm?ws® hot. S8^ ifigs. "&7H. AJf*. *a"fii^ J .- mss 3145 ' msa 11© 5 g& ass 335 ®$B SM 7fl» .m& S57 sis ."Tolefi© ©etroit "D.Xt.&s: Holly Fiiat A-2a> T^M. P.M. , 5-S© 0S1 258 9G21 8BG> X8& im 811 iw im 1W> ICS 723 *sf^5 5=15- OSS €^!S £3£t> 7^6 SET*. -059 t«5 JD58 S.2S SET- 3.C0 BBS- - SUSS OSS £35- 30^> . 10 Sep. S2& fi^s. 5® ^o^_Sa^Sa^mw__f|'8 "Qgo #-051 winter,,snd: as a 'conseo^ieiic© the snow plow failed to do its duty last Monday and people were, -obliged to wade knee deep* "HeoiioiBy in -a "wrong direction. - Bern* Je^erieSg A. "W- M-qnEeH andton. Biow© air© the intelligent ioice. employed ta the Bemocmat office, and It keeps) as hissy all day, and f ar iaito the evening, to torn ont the large asionnt of work received. Onr **®bw type, good work and low prices air© capturing the patronage [of the 3*s"aM*tade. - "JL F^ljghn©!*, of tMs plaee3.asid his part- —*i*oA aS0 §®.IGCOls©l,l®ayI).lS,ssHLS§0 1109 SastSs^aaw* 1130 550 CJole-saati Sv-aart Me&S. City ILt-a-Saagtoa j^TBrasriBg tfee season ef M$>,v%gaMsms th® M. j Zj *§?. IMLr0Seaaji©3*sleaveiijiaisgtoaat 10:15 .p. I XZ* &BM.y {except Siamflay} eiEiviaag at Mil-J "OH'Q-fee^7^0 £3^ m., 45©-Q3aesS2t5Eig -^ritla. m<£srjai2ig * tis3i*as? <ffl; fl2lTsSl*Bo3s»- X2?*sl,i©fe'©4s o-asjfi© fit "*££•.© afesye sslaeies t© 1 £ZD.y CS%* ia lSa& U-aaateflL Sl^es aaidCaasi-l cDo* 3?<H* IMsIsas-s ot otfegg BBfagmaMon apply 5 62 417 815 *j ©23 856 "ffO 35d S^ S56 •745 157 5^1SCQ -i^TrTT -^ ffll ©EMtOb; LA3. T jSs^fi, tellfc^ Iner, Ifo. Stevens, «t 3B. Pleasant, entered £iiaa as J hspes ta *Sss €SimS;y. Siais^asB- s •risia 3921®% 6&J8& g-argfflgE. 3ii3©Ms©% £fifen Js*Hwfa SSlB ls'eBS wa^fiSKir€-3lSs BifiESss, Ea*©^ TMusgiir-% Scat •*33ifO*Jlme% OciiirEis £s*a#. £31 Slsfe 3Ski^'Mo-"HS? ^-ll'Sl^^S^Ba&SSsSa ~S^» « ©safe lint© cpafea fflgeeiflafion last week. They - pmchssed m one "^saser Im Ionia county & fiosi: of -sheep immhejmg 7f0, the con- Isfflessi-IflSi o^ wMcla. wili. wm$h " nearly f45f0SS,o 'f he '^■sB^enaeii- .starfci "Monday 1 ^jmom "for I®ni%. asd ifflsiiedtately CJK^EtasQeeS to'soxt sad loud iise sheep on fe^^rfi <ssss Ior -"-Mpmeaf %o BaAl®«- 2f %©:iB»k^.l2:©m fem feey esgpecJrto es^© s uMeell^.^ safflgj&i.o'ff tteffila¥est° wm&* J>r. John Lansing, -of C&IMasrille, was" a caller afc the De^oceat sislQe on Friday. He reports a very fair practice—as good as was expected. Mrs. Chas. Pitcher returned to her hone at Chieago last Tbu-t-sday after a few weeks' visit in Glare, the guest of her sister,. Mrs. 'Holbrook, of Ternon City. ' •• The DemocRxIT force have been engaged a part of the week;on a supreme court record, for attorney "W.. A. Burritt, of Harrison. The Democrat office is the only print shop in the county that does this class of work. The Isabella "Enterprise gays that "A boy in his "teens,T was recently arrested at Clare for drunkenness. Sorely, Clare will vote for the amendment." Guess the Enterprise has been wrongly informed regarding the arrest, etc. We are ready to print election tickets and slips on short notice. Briag them in as early as possible and we. guarantee you will not have to . wait .but a very short time before you can carry them away with you. Prices low. One of the finest pices of eatving we have ever seen was exhibited "to xis one day this week by Oliver Beemei% It was in the sh#pe of & cane .whittled' with a pocket knife by a woodsboy during his leisure, hours in camp, and is truly an artistic piece of work. ' lioufe Sable, of Lake; Gityi was in Clare over' Sunday shaking hands with old friends, the guest of Win* Wolsky. Louie was on his way home from Detroit, where he had been purchasing a stock of goods. He is enjoying a good business at Lake-.City. Louie was elected as one j of the village trustees at the ferst election a couple of weeks ago, receiving the largest majority^ but one, of any on the ticket. ..#■.-■-....--. All of the correspondents are '-teguesfr- j ed to continue in the good work they have been doing for the PMKBfAT. We realize that good correspondents furnish news that we can get in n© other way and as we are anxious to make the Democrat a live- newspaper we want your hearty assistance. "We have you on the list" and if you are. in need of stamps or stationery let us know ahd we will forward you some at once. Let us Inear from you often,.. .^j^J lfcsfnr*. nv*a Mis»u«H*.WM*l £&*■£ oth^j^S*^»ip} thlr ^xsjfi-ion ia do«:g job prfnting'^'and 710V) it makes them .green ""With envy- while gazing upon our work, besides our prices were always less than the others. * This office is in receipt of a letter from Elmer Halstead, from Oreana, Idaho, | which says: "We"are all well; the weather is very nice and warm; early fruit tress are mostly in bloom; hav© had a yery nice winter; enclosed find a piece of alfalfa and hunch grass, which cattle feed on here, 'tis this spring's growth." Prof. Wood, principal of the Clare schools, will deliver a lecture at the Congregational church this evening, His subject will be "The effect of alcoholic spirits upon the human system." He will-have the manikin from the school present from which he will refer and have to assist him in his remarks. The lecture will, undoubtedly, be very interesting. ' The Detroit Tribune, of the 17th, contained the following item: "L. T. Olds, of Clare, has one cow which from April oth to October 15,1886, gave an average of 24 quarts of milk per day, which he sold at five cents a quart, making $219.60. From October 15 to March 1, 1887, she averaged 15 quarts a day, which he sold at six cents, making §122.90^ or a total for 11 months of $342.50, whieh that one cow has brought her owner. The milk weighed two pounds to the quart. The cow is four years old, half Ayrshire and half Durham, and weighs 250 pounds." "Mr. Olds handed us the item and says that he can swear to its veracity. Hose Co. "N"©. 1 met at Doherfey's hardware store last Tuesday evening and organized by electing the following officers : Cap. andCforeman, David Borison; assistant foreman, J. F. Tatman; secre- "Nearly time for sugar making, " Township election next Monday. The salvatidn army have struck Sslfe Biver. ■ Miss Winnie "Merrill visited -friends ia . Salt Biver over Sunday, . Attend the hose company's dance afc the:G, A. B. hall tonight. " * Our merchants talk- of organizing a Business Men's Protective Association,. It would be a benefit to all concerned.- Messrs. Charles T" Bussell, of Wk>'.. Pleasant, Chas. J. Willett, of Ithaca, and Jas.-K. Wright of St. Louis, were in.town on Tuesday. ' On an inside page will be found a biographical sketch, with portraits, of the nominees on' the democratic state ticket. Bead it carefully. Property is changing hands quite rapidly in the village this spring, and is he-, ing purchased principally for the purpose of erecting dwelling thereon. Mr. and Mrs. H. M. Boys and Sd. Mc^' Milieu, of Farwell, were in. attendance afe the dance tendered by the druggists. at the G. A. B."hall last Friday evening. . There is a move on; foot by the peopl© of Bay Citv to have the county of Gladwin placed in that judicial district if it is agreeable to Gladwin county people. • T. P. Horning, of Mt. Pleasant, was Iii' town Monday and Tuesday; A close observer can see that there is a feeling rak=>. ing in T. P*"s big heart .condemning the* movement* when he left onr booming' burgh. 0n@ of the neatest and best printed. papers that reaches our exchange .table is the Washburn (Wis.) Bee. Vol. "3, -Ko. 1, has been received by ns and with Editor Warden's usual push'is better' than ever. C. W. Bobinson will move Ms "fsimflj up near Gladwin, where he. has ; a cour tract of getting out a large - amount of hemlock bark this spring, to be delivered on the line of the new Pinconning ' and Bay City railroad to Gladwin. • Nothing new in the line of railroad * ■news this week. Superintendent of con- strnction Carling, Engineer -White and Attorney Graves' -have Seen"" working "seeming the -right-of-way near -CalMnr;«. ville dmisig .the week/and wthe road will beb-dlt to Clare early m the svwjlrag.'3 The contracts of ** ?. 111 < *; • ■ * .'. ■ • -. ; ; ~* Gomziy Bank imii k;oh&*ijy's '!2&~sCz,zz- store have been awarded. A. A, Shaver,. of Clare, was given the contract of- the carpenter work, and the brick and stone ■ work -was awarded -to gentlemen from Midland and Saginaw—the parties who erected .the fine Larkin bloek' at Midland- last season. . 'W®^ Theodore Bogue, the boot and shoe dealer, reports that his trade has- ■ more than doubled since he moved into* his new, quarters. The reasdn for this is very plain. He has largely .increased his stock and handles, the best goods that can be bought, besides his prices are not duplicated by dealers in this.section* His repairing and custom work gives perfect satisfaction and his charges ..ar© low. Watch for his new advertisement next week. ■ Wm. Dwyers-large new boat house, at Crooked Lake, was destroyed by fire last" tary, Erny Elwood; treasurer, J. B. Phinisey"; 1st nozzleman, B. "M. Musseli-; 2sd nozzleman, Will Curtis; assistant nozzlemen, A. H. Boekafellow and Irving Aiward. They appointed -a committee to settle with old treasurer, and one to solicit additional funds, A committee was appointed to procure and form regulations and by-laws, and also a committee to procure catalogue and price-list of caps, belts and imiforms. The boys are] taking hold of the matter as though they mean business. The meeting* adjourned 'to assemble again next Tuesday at the »same place. Wednesday evening. The work is supposed to be that of an incendiary. Luckily his new boats had not been stored therein and were not consumed by the flames. He has ordered several new clinker row boats that will arrive in a few days, which, in connection with his others, will make him a complete phar=- aphenelia. Material is already on the grounds for the erection of a new boat house. We have to announce this week the unexpected demise of Katharine, wife of Mickael Dalton, of Vernon township. She was taken ill Sunday evening . of a severe headache and continued to grow worse until Wednesday evening, when she died, her death resulting- from apoplexy. The deceased was 31 years of age. She leaves to mourn her death, a husband and four children, all boys, the eldest about 12 years of age. The remains were taken to Saginaw this morning for interment. Two sisters from tlie above named place arrived Wednesday evening and reached her bedside only a few minutes before her death. The relatives have the sympathy of the community. . ¥^11! is© in ©ifclw * I wish-to' announce fo the people of Clare and vicinity Ijhat I will be In Clare Tuesday, April 5,1S87, .and-, will remain three days. All persons-who wish medicine or to eonsiilt -with me will-'please call. Di*%W**ir..DwTOB, • Datedj-CadiBaCj March 28, r MMWtawHNMUHil
Object Description
|1887-04-01; Clare Democrat
|M.D. Eaton
|Friday, April 1, 1887 issue of a Clare, Michigan newspaper. Published weekly. Began publication in 1880's. In 1889, merged with The Clare Press to form The Clare Democrat and Press.
|Clare (Mich.) - Newspapers; Clare County (Mich.) - Newspapers;
|Copyright Permission
|This material is in the public domain.
|1887-04-01; Clare Democrat
|M.D. Eaton
|Friday, April 1, 1887 issue of a Clare, Michigan newspaper. Published weekly. Began publication in 1880's. In 1889, merged with The Clare Press to form The Clare Democrat and Press.
|Clare (Mich.) - Newspapers; Clare County (Mich.) - Newspapers;
|Copyright Permission
|This material is in the public domain.
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text:
A Roundup of Mushrooms
For a very long time, the only mushrooms I knew about were button mushrooms and the canned straw mushrooms you'd get in your stir-fry at Chinese restaurants. I liked them fine, but little did I know there was a whole world of mushrooms out there to discover. Eventually, portobello, enoki, and shiitake mushrooms found their way to me.
I spent a year in Tuscany on a study abroad program. There, I was introduced to the porcini and the white truffle. Delicious!
A trip to Seattle introduced me to the fruity chanterelle. Then I moved to San Francisco and discovered Far West Fungi. I would go there and stare wide-eyed at all the different kinds of mushrooms that I'd never heard of before, such as lobster and wine cap mushrooms, and wonder what on earth to do with them. Traveling in Japan introduced me to the matsutake. I got an oyster mushroom kit and started growing them at home.
I had a friend from Russia who would tell me stories about going to pick mushrooms in the forest, and I knew many people in France and Italy who foraged for both mushrooms and truffles. I wanted to learn how to do this. But how? Where? I didn't know anyone locally who did this. People I grew up with didn't do this. It was intimidating as heck. Eating the wrong kind of mushroom could kill you! And then I discovered the Mycological Society of San Francisco, and started going on forays with the group and my Opinel knife, and learning more with the help of the member email list and David Arora's books.
And now, after many forays, I can safely identify chanterelles, porcinis, and morels. Mushroom foraging has opened up a new world for me. When I look at the hillsides and mountains, I think about the mycellium running underneath them. I know when the air gets colder and when the rains come, delicious treasures will be found under those trees.
More mushrooms:
• Wood Ear
• Pink Oyster
• Abalone
• Maitake
• Shimeji
• Black Trumpet
• King Trumpet
• Hedgehog
(Images: Kathryn Hill, Flickr member ulterior epicure, Wikipedia, PaulsFinest.com)
1 Comment
I'm slowing introducing my husband to mushrooms. He goes out of the way to make sure he doesn't eat button mushrooms and if they're canned FORGET IT! I grew up amongst 48 acres of woods in New Jersey and my parents took foraging classes just like you. We would always have amazing morels (stuffed with crabmeat!) and "chicken of the woods". Now my husband will go out of his way to order items on menus with morels and has become more adventurous. I think he would enjoy a class because finding your own is even more tasty :)


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