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Friday, March 21, 2014
A Night Under Covers
Also – Know Lyfe (System of a Down) + Freak on a Leash (Korn) + Deveraux (Guns N' Roses) + Damn Van Cannibals (White Stripes) + Mr. Denton on Doomsday (Queens of the Stone Age) + Beats and Angles (Tool) + Pacifier (Rage Against the Machine)
Come out to see your favorite local bands all packed into one night in the third annual Night Under Covers! Each band will take on the persona of their choice, impersonating everything from System of a Down the White Stripes and plenty more.
- Admission – $10 ADV, $15 DOS
- Doors – 6pm
- Ages – All


text: For a good period appearance try a heavy waxed linen or waxed cotton cord. http://www.dellsleatherworks.com/waxlinenthread.htm http://basketmakers.org/topics/supplies/supwaxlinenindex.htm http://www.basketmakerscatalog.com/Merchant5/merchant.mvc?Screen=CTGY&Store_Code=TBMC&Category_Code=WXED <http://www.basketmakerscatalog.com/Merchant5/merchant.mvc?Screen=CTGY&Store_Code=TBMC&Category_Code=WXED> -EA Lawrence wrote: > > *Greetings all, I have read about some of the different materials used > to bind the prods but most look to modern to me and I would like it to > have a more period appearance....it doesn't have to be the true period > sinew...but what will work...not stretch and such but still have a > "close" appearance?* > > *Thanks* > > *Lance* > -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://lists.ansteorra.org/pipermail/ansteorra-archery-ansteorra.org/attachments/20090406/ceee053a/attachment.htm>

subset: commoncrawl


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UCB Comedy Improvisation Manual
If I wait until I write a whole proper review, I'll never say anything so I'm going to indulge myself in a blogger-like fashion to just list disparate thoughts without minding heightening or following through. This is an opening for a Harold-like review of the book that I will likely never write.
Short version: I love it for its ambitious scope, its directness and its earnest treatment of improv as craft worth doing well. There is no other book that explains as much, certainly not written by people with as much experience. A trade-off is that it's (perhaps necessarily) less inspiring and fun than other books. But that is in my opinion outweighed by the amount of thought and care that's gone into this, the first complete documentation of improv as a serious artform by one of the most experienced and talented groups in its history.
Long rambling post after the jump!
Disparate thoughts
It's impressively, maybe even intimidatingly BIG. It's a college textbook, not a slim volume of inspirational essays. It covers how to do improv according to UCB style and it describes EVERYTHING, including basic scenework principles to finding game to longform structure with long sections on openings and even a chapter on running proper rehearsals and performances. There is no other long-form book that attempts this scope.
It's like the old school Gary Gygax Dungeon Master's Guide! For real! The book takes something you may have thought of as playtime and treats it with passionate thoroughness. Chris Scott compared it to an RPG manual (favorably) and I agree with that comparison!
It feels like workshops with Ian or Besser or Walsh. It has their directness and confidence, and also their clarity. Ian's voice in particular is clear, especially in analytical abstract descriptions of patterns when playing game. It puts as much a priority on finding comedy as it does simply cooperating and supporting. It makes improv feel teachable.
Despite the directness, it's not saying this is the only way to do improv, just their way. Although the completeness of the book's scope may imply the UCB wants to be the final word, I don't think that's the tone of the book. The tone is "here's how we do it" not "here's how YOU MUST do it."
The drawings by David Kantrowitz are beautiful and clear and add a lot to the book.
Joe Wengert, the editor, was in my opinion almost a co-author in that he wrote up the drafts based on the discussion and notes from the UCB. It's the UCB's book, but having someone as smart and funny as Joe —- who has a masters in education and ran the UCB school for over 6 years —- was an enormous boon to the quality of this book.
This book is more about how to do it than how to teach it. The art of teaching improv has a lot to do with running reps of exercises, of inspiring people to be confident and playful, of securing one set of skills before doing another, with keeping it simple. This book is not trying to fill you with the fire of improv. It assume you have that fire, and is instead focused on the ambitious task of being awesome at it. Which is in itself inspiring, but not as directly as some well-chosen anecdotes about following the fear or the magic of group mind.
It's about making a beautiful watch, not being part of a fired-up congregation.
No Arbitrary Choices
If there's one consistent theme throughout, it's that improv should avoid arbitrary choices. From the second paragraph, which argues against the perception that improv is lazy, and then throughout the book, the UCB are declaring as their overall philosophy of improv (in my opinion) to always serve a larger purpose: either you're making a grounded reality, or you're serving the game. Anything done out of randomness or pure silliness is likely destructive, the book says again and again. From their philosophy of object work, to theory of what makes a good character, to avoiding ironic detachment, to whether or not to have your animals talk —- the book goes back to instructing you to serve the larger purpose of the scene and not fall back on silliness.
That's a harder battle than it might seem to people who don't do improv. Improv can be silly. Audiences like silly, at least in the short term. And for the droves of non-actors drawn to study improv, it is very tempting to simply indulge in the joy and novelty of being on stage and making things up as enough to justify ones presence on stage. Many many people who do improv do little than go from moment to moment, indulging in arbitrary object work and barely-justified emotional reactions and pointless references. If there were one overall cause that the UCB would get behind, I think, it would be a war on "crazytown." You must have a point, a purpose when you make your improvised scenes.
Game Of The Scene Defended
The UCB's devotion to "game of the scene" has provoked many arguments from people. This book is more practiced and savvy at anticipating those arguments. Not that this book presents the discussion like an argument, but its descriptions contain within itself answers to common criticisms. Criticisms I've commonly heard from people who don't like seeing scenes as having games are things like "people just boss each other around" or "you're writing on your feet —- not really building ideas with your scene partner." The book has repeated emphasis on listening, supporting, committing all throughout the game section ("Work together to play the game", page 148). Game as described in this book is still ultimately a cerebral approach that won't inspire everyone, but the book anticipates the initial misgivings and speaks to them.
Certainly, the themes of "listening" "committing" and "making your partner look good" are hit again and again and again.
Other examples of this: I'm looking at pages 78-92 right now —- the "revisiting yes and" and "revisiting agreement" sections through "filtering through status" and finally "crazytown." These sections explain how commitment, listening, support are the fundmental skills of improv, even to these admittedly analytical, game-hungry improvisers.
Improv teaching is so much about semantics and phrases. The UCB have thought through all the semantics, changed some and redefined others.
I find that semantics is where most improv arguments are born. People have terms that work for themselves and get territorial about those. For some people the words "game of the scene" simplify their approach, for others it will muddy it but the phrase "point of view" will get them behaving almost the exact same way. For some "commitment" and "grounded reality" make them into better actors, and for others it will be "relationship and emotion." Improv is ultimately an art form and one person's internal experience will never be completely universal.
Having said that, the semantics in this book are fascinating, smart, comprehensive and do fairly represent how the three authors play. I could write a whole essay on these, but a few quick comments.
"Yes And" is slightly redefined, or maybe it's better to describe as "re-focused" as meaning the discovery and initial exploring part of the scene, and then once you have your game you switch to "if this unusual thing is true then what else is true." But I can easily imagine an improviser arguing that "if this is true" is simply a re-statement of "yes-and." Sure, if you like. You're the boss of you, have at it. But the UCB are arguing that there is a switch in priority once you have a game, so let's reflect that in our terms. We "Yes-And" till we have a "game," then we "If-Then." It's not the final answer, it's AN answer.
Even the decision to say "if this unusual thing is true, then what else is true" is an evolution from "if this is true, what else is true" which is how it was said when I took classes.
"base reality" replaces "who, what, where."
"premise" vs "organic" improv is a UCB categorization, I believe.
"chaff, half-idea, and premise" as the three types of initiations off an opening is a UCB categorization.
Codification In General
There will be many who think the whole purpose of that much codification is pointless. Improv is art, not a computer program, so why try to make a formula? I guess I would argue that the people who don't like this approach should and would select themselves out by not buying or reading the book. That is a non-offensive position to take, I think.
But in teaching improv, I have found that the right set of "rules" and principles and mantras can be a big help. They give the right mindset and posture. Later, when the improviser has developed his/her own voice he/she may find that certain mantras are important whereas others are not. But for the student who's learning, I'd think the UCB's suggested models would be a relief.
I mean if Ted Williams can write 96 pages on swinging a bat, I think the UCB is entitled to write 380 pages on the art of making up comedy on the fly.
Many people won't try to "solve" improv the way this book tries to. Many teachers, understandably, like to leave improv as a few principles — "play it real" "find an unusual thing" and "heighten" and pretty much leave it at that. It is interesting to see three people who have done it for years refuse to settle for that. When the book explains strategies of initiating —- "on the nose" vs "one step beyond" —- you may roll your eyes with how precise they are trying to be, or you can be impressed that they are tackling the intimidating job of trying to feel the rules of comedy!
Certainly anyone who reads this blog with any passion would love the book. Read three of the biggest improv nerds on the planet answer every question you could imagine on how to do it.
What Will Last
I think there will be some evolution now that the book is out. Some things will stick, some will not. That's certainly happened with previous books. After "Improvise" by Mick Napier was published I heard many people using his descriptions of things like "your deal" as opposed to more formal terms. I've heard many of his specific examples from "The Perfect Actor" cited. But I haven't heard many people cite his analogy of thermodynamics as it relates to improv. The masses will eventually decide which of the UCB's semantics and ideas are lasting.
But let's remember the credentials of the authors. They studied with Del and Charna and every great teacher in Chicago in the early 90s, one of the most fertile and creative periods of improv comedy. They founded a theater and within just a few years had fostered it into a major player in the comedy scene. They have done improv, continuously, for over 20 years with the best people in the country. The points in this book have been developed in thousands of hours of shows. It's completely exciting to read the thoughts and beliefs of people who have done improv as well for as long.
Some Cool Parts
Page 108-109 "Responding" and "Give it Time" in relation to premise improv. Their discussion of the importance of responding (and not being in your head assuming you know the answer that's coming) and also the reassuring words of how hard premise stuff is at first show that these are guys who taught classes, and are not just casting down carved stones from mountains.
page 137-147 The book gives a painstaking analysis, line by line, of a scene to explain which ones heighten, which ones explore and which ones are playing top of one's intelligence. Though I don't know, it feels like an Ian analysis. And to see Ian's insanely powerful and machinelike improv brain tackle a scene is, frankly, weirdly exciting? I'm sure it's intimidating to new students also, as in "shit, am i supposed to be analyzing scenes that much?" No, and the explanation says as much. But this section is like having The Chicago Bulls give commentary on how they scored ten points in two minutes.
page 189 - "Playing Animals and Inanimate Objects" — I just love that improv is such a medium where this is a reasonable topic to have an opinion on.
page 253 - The invocation of Del Close. For all of its analysis and textbook formatting, Del is still present in this book and the authors' respect for him is apparent.
page 279 — The "paint pouring over a sphere" drawing by Kantrowitz is pretty fucking cool.
page 297 - "What do you do when the game isn't clear" in regards to second beats, is a question every ucb 201 student asks. I like that they speak to it.
page 304-309 - They offer categories of group games, which is something we didn't do when I was taking classes. this is an area that students ask about a lot ("how do you do group games?") and here the UCB is offering an answer.
page 362 - Getting out of your head.
No book can substitute for experience on stage, and this book does not break that rule. Nor is this book the final word on the subject and it's not trying to be. But it IS a thorough, careful, honest expression of how best to perform an art form as seen by three of its best practitioners. It raises the bar in terms of thoroughness and scope. It's really cool and I'm excited to have it!
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i need to get my hands on this 'manual'
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Fascinating review/thoughts by Will Hines on the new UCB Comedy Improvisation Manual book.
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Kind words from Will Hines about my illustrations!
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The "Welcome to Crazytown" illustration in the book is real fun.
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I will be buying this tomorrow, finally.
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Great Southern Hotel Melbourne
So much room and a great little atmosphere in the room to share with friends
The unit was quite spacious.
It was extremely noisy and an ensuite would have been nice
the size was generous, the beds good and staff were so helpful.
the bathroom had no lock or extractor fan. This may sound like a small thing but we were in a family unit with six people and this was a nightmare. Also the cooking pans were the poorest quality and it was impossible to cater for the family with them .
Staff always helpfull & friendly
No negative comments could we make
The apartment living gives u the privacyand comfort u need. A home away from home thanks very much. Staff were very friendly Ben came to our apartment to help with dvd player. Staff excellent. Cleaners lovely and helpful. Thank u for our stay. Had elderly parents with us 92 & 88 they enjoyed their stay as well
Some guests a bit noisy returning early hours of morning.... in holiday mode I suppose
The Location
The room cleaning service was terrible
The secure car parking
Every thing else
it was pretty central public transport right out the front walk away from cafes and shops close to st kilda beach as well as the city before arriving i didnt expect it to be so central but it was one of the best locations i have stayed at while in melbourne! it was exactly what we needed for our weekend stay and as close as each rooms are to eachother there was little to no noise only during the day time when people were walking past :)
the elevator had a bit of a weird smell kind of like mechanical oil.
Plenty of cupboards Separate bedroom Location Friendly staff
On the whole I enjoyed my stay
Any noise of an evening (people getting home from a night out), especially late, echoes through the whole building.
Layout was excellent. Security was good. Comfort was great. Access to public transport was excellent. Friendly, helpful welcome on arrival. Prompt assistance from staff to replace blown lights.
Access to shower was extremely difficult for my wife due to her osteo-arthritis. Rowdy guests all night (till 7am) meant a restful sleep was impossible. Lack of management staff to control the rowdy guests in the late night-early morning time. Blanket didn't fit the bed.
Great value for a family weekend
Staff were great, bed was comfortable
The room could have been cleaner. There were stains on the carpet, kitchen light didn't work and it had a smell when I entered room even though the windows were left open. Location is awkward sitting on a big intersection.
The staff were very friendly and approachable. Immediately we felt right at home and welcome. The size of the apartments were great and everything was provided to make the stay comfortable and relaxing. We settled in very quickly and were quite sad to leave! If I was coming back to Melbourne I would definitely be looking to stay here again, it really was like a home away from home.
Unfortunately, the hot water kept running cold in the shower. The staff were helpful in trying to fix it but it kept happening. It was the only negative aspect of the stay.
The staff were very welcoming and helpful, parking was available, room was clean, neat and tidy.
sofa bed for fifth person was a little uncomfortable as they tend to be.
there was strong odour in the room, guessing from previous guest cooking in the kitchen, it wasn't pleasant.
Liked the location, very easily to get to. The undercover parking also. The guy that was on when we got there was helpful even though we arrived later than expected.
The fact our accommodation booking was incorrect. We are 2 couples so booked for 2 king beds, got 1 king & 2 singles. We had to put them together ourselves because all the other rooms were the same. When they told us about the other rooms being the same, the person at reception asked if it would be a problem to be seperated for one night. Um.. yes!! The hot water and lack there of. There was 4 people in the room. 2 had a shower in the morning, then one about 7pm & when the next one went in, there was no hot water.
Great location close to everything room was good size and staff were more than helpful and great customer service
Room had a strange smell not a "clean" smell
Handy to the tram lines so was easy coming to and from the city centre...
Lots of room need TV in main bedroom sofa bed was broken couch wasn't very comfy but over all suited us
No TV in main bedroom sofa couch broken
Staff at reception were very professional. Room was spacious and had everything. Loved the balcony. Excellent value for the money. And the location is good.
The fact that there were no stairs up to rooms so you had to wait for lift just to go 2 floors in our case, which was slow.
Location was great, tram stop right outside, plenty of trendy eateries down the road, quick tram trip into the CBD. Room set up would be perfect for longer stays as has extras like dishwasher, washing machine/dryer. I will stay again ;o)
The couches were a little stained, but overall the cleanliness was above standard.
Location was excellent, close to public transport, great restaurants and the city. Rooms were comfortable, beds very comfortable great for a family stay. Will definitely stay with you again.
The security was reassuring, friendly and helpful staff members.The house keeping staff were perfect when we asked for help.
I just feel a little bit more attention when cleaning the room walls, benches and vacuum under the table and lounge suit, other then those little things we enjoyed our time and will be more then happy to return again.
Stayed here previously but this time room was very ordinary, most cupboard doors broken, blinds in bedroom wouldn't close properly! Thankfully only stayed 1 night.
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I drove my ass off today to get to the upper part of Mississippi for the Mississippi Riverkings vs. Colorado Eagles playoff game tonight. More to come.
Mississippi Riverkings Tonight!
April 24, 2009 By 1 Comment
You're in the South already – why not just pop over here for a beer or 15? Go Eagles!
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That Galaxie is a 1967, not a 66. The 66 grille and nose are flat, not pointed. Source: I own a 67. »
I just so happen to work on one of the block machining lines for the 3406 at Caterpillar. Gotta love the small world of Jalopnik! »
The fact that you've already resigned yourself to talking about the K900 in the past tense is telling. »
Not sure if this has been posted, but 5 series wagon, row-your-own 5 speed, and according to seller, "NO DEAD PIXELS" AND "tires is good". »
I can't post pictures, but the last generation Camry Wagon that was available in the US. Dat ass looks plain weird. »
Despite what Lincoln would have you believe, those letters actually do mean something. MKX and C are both code for crossover, MKZ stands for Zephyr (the predecessor based on the Ford 500), MKS is sedan and MKT is touring. I worked at the top Lincoln dealer in the country, and this was the explanation I got from FoMoCo… »
Achievement Unlocked: Earn A Unit Nickname. "Pinata" (In all seriousness, hope he makes a full recovery.) »
I actually believe that it's targeting the likes of Aston Martin, Mercedes SL, and I'm not entirely sure, but potentially the GT-R. The Corvette is a Grand Touring car, with the Z06 being the option of the buyer who ISN'T buying it in response to a midlife crisis. »
You would think they would have an auto self-destruct set to activate when there is an anomaly detected. Also, where's the dash cam video? (Obviously, because Russia.) »
I have been a commenter for many years...
...and even earned the coveted golden star, but I still do not have approval to post comments on some articles. »
Awake, and just getting off my shift. Seriously, my normal work schedule is 1630-0300. I miss the Sun... »
Looks to be a Country Squire 2 dr concept based on the 2 dr Galaxie (see my avatar for reference). Possibly what a "modern" contemporary of the 1950-9 Country Squire would have looked like. »


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Isis with Tom Trago
Tom Trago's relationship with music is particularly intense. "I couldn't imagine life without music," he says. "I feel this physical need to make music every day. It's like my body needs it as much as it needs food, water or sunshine." Right now, Trago's immersion in music is almost total. An internationally renowned DJ, producer, live performer and label owner with three critically acclaimed albums to his name, the Dutchman divides his time between all-day studio sessions, DJ gigs and live shows all over the world, and a steady stream of musical collaborations with friends from Amsterdam and beyond. You sometimes wonder how he finds any time for sleep. His dedication to the cause has been unflinching since his earliest years. He grew up in a free-spirited, artistic household, surrounded by music and encouraged to make his own. Due to suffering from juvenile chronic arthritis, he couldn't get out of the house much, so entertained himself by recording his own home-made radio shows using the weird and wonderful albums he found in his parents' record collection.
161 Erie St.
San Francisco, CA 94103
Phone: (415) 779-6757
Website: Link
Saturday, Mar 15 09:30 PM
Price: $10-$15


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Omar raises Pathribal closure case with PM
Jammu and Kashmir Chief Minister Omar Abdullah Sunday raised the issue of closure of the alleged Pathribal fake encounter case by the army with Prime Minister Manmohan Singh and demanded justice for the kin of the victims.
The prime minister arrived here Sunday afternoon on a two-day visit. He is scheduled to inaugurate the 101st session of the Indian Science Congress at Jammu University Monday.
Abdullah called on Manmohan Singh at the state Raj Bhawan.
"In the meeting, Omar Abdullah raised the issue of closure of the Pathribal case by the army and emphasised the need for giving justice to the families of the victims and punishment to those responsible for innocent killings," an official statement issued after the meeting said.
"The chief minister also discussed suspension of trade across LoC (Line of Control) after the seizure of a truckload of contraband drugs and stressed the need for amicable resolution of the matter with Pakistan so the important confidence building measures of trade across the LoC is not jeopardised.
"The chief minister apprised the prime minister of the achievements registered by the coalition government during the past five years in the state in various fields of socio-economic development, empowerment of people, employment generation and restoration of peace and stability. Matters pertaining to security and law and order also came up for discussion in the meeting," the statement said.
"Omar Abdullah expressed gratitude to the prime minister for his support to the state in its endeavour to fast track development and move ahead towards achieving the cherished goal of prosperity and tranquility.
"Omar Abdullah wished good health and well-being to Manmohan Singh which he reciprocated warmly. The prime minister also wished peace and progress in the state and well-being of its people," said the statement.
(Posted on 02-02-2014)
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BookwormsWritten by childrens library on 01/21/2013
Thursdays at 4:15 p.m.
Join us for a weekly crafty storytime. Past activities included drawing like Michaelangelo (lying down and creating art on the bottom of a chair) and creating marshmallow rockets. Drop in to find out what's happening this week!
Ages 5 to 7.


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Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
Prep Time:
Cook Time:
96 hrs
1 hrs
A classic Greek inspired dish.
Units: US | Metric
Htapodi Me Makaronaki Kofto (Stewed Octopus With Macaroni)...By evelyn/athens
Serving Size: 1 (158 g)
Servings Per Recipe: 8
Your life in the kitchen will never be the same.


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On the MySQL Proxy channel we get questions from time to time if the authentication can be intercepted and replaced data from a external source.
From now on, you can. For example if you want to get data from a external source (like LDAP) or want to implement roles.Mapping Accounts to "Roles"
There isn't much needed to implement Roles for MySQL with the help of the MySQL Proxy.
mysql.userdoesn't contain users, but roles instead
- the proxy maps user-accounts to role-accounts with a script like above
It works like this:
login to the proxy
$ mysql --user=jan --password=secret --port=4040
proxy looks up username password, finds a role for him
proxy replaces credentials ad hoc
mysql-server sees the role-name and


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North Carolina Literary Review 2013
CLR Online is an open-access supplement to the award-winning North Carolina Literary Review. Since 2012, the book reviews and literary news that used to appear in our annual print issue are being published in the electronic issue, along with some content related to the year's special feature topic. Providing book reviews to as broad an audience as possible helps to fulfill NCLR's mission to serve as ambassador for North Carolina writers.


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Full Disclosure
mailing list archives
On Wed, Oct 24, 2012 at 4:08 AM, SEC Consult Vulnerability Lab
<research () sec-consult com> wrote:
SEC Consult, an international leader in application security services and
consultancy, and Capgemini, one of the world's foremost providers of
consulting, technology and outsourcing services, released the first
international study on security of 3rd party Core Banking Packages.
The study summarizes the vendors' promises, commitments and relevant
activities relating to the application security of their products. As a
'reality check' three Core Banking products have been tested and severe
security vulnerabilities not detected by the vendors have been found in each.
The study emphasizes that state-of-the-art application security has to be
demanded and consecutively validated by application security tests. Failure to
do so can result in the implementation of insecure software products and incur
operational risks.
A summary of the study can be found at our blog:
On a side note, we also have a new look and new contents for our homepage:
Study information:
Send an email to get the study? Seriously? It appears you have used
BugTraq for a press release...
Full-Disclosure - We believe in it.
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Hosted and sponsored by Secunia - http://secunia.com/
By Date
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Pavano and Ponson, huh? That's a battle of titans.
Let's try and clean things up here. If everyone is cool with it. We can discuss all games here.
Yankees @ Twins tonight.
Pavano on the mound for the Yankees
Ponson on the mound for the Twins
Thank god we miss Santana this series.
Last edited by Tyler Durden; 04-09-2007 at 12:56 PM.
Pavano and Ponson, huh? That's a battle of titans.
MLB Baseball, it's fantastic!!!!!!!!!!!!!Originally Posted by pauliec
The Twins have the worst 3, 4 and 5 starters in the AL. Ramon Ortiz, Ponson and Carlos Silva, yuck.
Pavano better pitch 6 or 7 innings today.
The question is whether they are quality or not But you are so right, our bullpen has been amazing. But at this rate, they won't last another week.Originally Posted by JeffWeaverFan
Anyone know if Damon is playing tonight? If he is I would then assume Melky in LF.
Yep, starting in CF and batting leadoff. Here's the lineup tonight.Originally Posted by Sean Ryan
Johnny Damon CF
Derek Jeter SS
Bobby Abreu RF
Alex Rodriguez 3B
Jason Giambi DH
Jorge Posada C
Robinson Cano 2B
Doug Mientkiewicz 1B
Melky Cabrera LF
Carl Pavano RHP
Thank god. Melky in the lead off spot was ugly. If Damon wasn't able to play I would have liked to see 1. Jeter 2. CanoOriginally Posted by JeffWeaverFan
you guys going to lose lol
HA HA HA HA HA! NOOriginally Posted by NYJ Fan18
Here are both teams starting lineups.
1. Damon CF
2. Jeter SS
3. Abreu RF
4. Rodriguez 3B
5. Giambi DH
6. Posada C
7. Cano 2B
8. Mientkiewicz 1B
9. Cabrera LF
Pavano RHP
1. Castillo 2B
2. Punto 3B
3. Mauer C
4. Cuddyer RF
5. Morneau 1B
6. Hunter CF
7. Kubel LF
8. Redmond DH
9. Bartlett SS
Ponson RHP
Originally Posted by JeffWeaverFan
y'know what really hurts your lineup?
mr. mientkewicz
I disagree. He came up with a big pinch hit bunt on opening day. So far he is batting .333 with 3 hits 2 runs with 9 at bats. I think he is a pretty good role player and is great defensively. Do you really need an all-star 1-9?Originally Posted by neckdemon
Originally Posted by Sean Ryan
Yeah he's fine for what he does; he's a good defensive player too
He kills you with the stick but he's a good defensive 1B.
Good start for the Yankees
-Double by Damon
-Infield single by Jeter
-RBI single by Abreu
-Walk by Giambi
-2 RBI ground-rule double by Posada, who is hitting very well.
3-0 Yankees. Alright come on Pavano!
It's obviously very early, but he's been okay so far. If he has a .359 OBP like he did last year, he'll be fine.Originally Posted by neckdemon
HA HA HA YEAOriginally Posted by Sean Ryan
Originally Posted by Sean Ryan
no, but i am basically going by what i saw of him when he was a met 2 years ago.....
great in the field, but too much of a liability at the plate.....
well, the mets lineup wasn't quite as deep then as it is now, you guys have a deep lineup so i guess you can carry his bat
2 run HR by Abreu. Really good at bat.
5-0 Yankees.


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Nike Air Trainer Huarache – 2001 vs. 2011 Retro Comparison
April 7th, 2011 by Aaron Kr. | No comments
Nike recently re-released the 'Raiders' colorway of the Nike Air Trainer Huarache, the game-changing Nike Trainer shoe that served as the blueprint for the widely successful Zoom Huarache TR Mid. Of course, manufacturer quality is always a hot-button issue with Nike Retro releases, and with Nike trying to maximize its dollar while being environment friendly, there will certainly be noticeable differences as the years go by. Here's an interested side-by-side comparison between the 2011 and 2001 Retro releases of the Air Huarache Trainer; even through these pictures, the texture of the materials and shades of color have clear discrepancies, but determining which of the two is better is up for debate. If you have plans of copping these or any other Huarache Trainer, check out this comparison below and let us know what similarities or differences stand out to you. Thanks to Alex for the images.


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Search found 252 items
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Satire! It's simultaneously the most omnipresent form of comedy, the hardest to define, and the hardest to competently pull off. And considering how it's becoming increasingly present in our culture, the ability to distinguish satire is a skill you desperately need, else you turn into one of those people who…
Sun, Apr 13, 2014
Oh, Lily Allen. To think that you were one of the first major musicians to rise to fame because of social media sharing (hello, MySpace!). The rise of "LDN" [1] and "Smile" [2] helped Lily Allen become an "it girl" among music bloggers (when such a thing was new). A couple…
Wed, Nov 13, 2013
All The Rage will cause only one kind of rage
Wed, Oct 20, 1999
Spoof article used to attack London anti-bullying program
Wed, Apr 14, 2004
Sexuality hits the stage
Thu, Mar 10, 2011
From supercharged wit & menace to bathetic melodrama
Wed, Dec 15, 1999
Challenging the idea of 'gay' with extreme sexuality
Tue, Oct 21, 2014
Law lets parents pull kids from classes on sexuality
Sun, Jul 19, 2009
Councillors approve ordinance that blocks hiring of replacement
Wed, Apr 23, 2014
Who's who of queer artists in attendance for Crawford's hilarious one-man show
Tue, Jun 28, 2011
Love-in to support SummerWorks production
Thu, Aug 7, 20084
Apple bans gay satire comic by Northwest Press
Fri, Dec 6, 2013
It almost feels dirty trashing Christian pop songs at this point. Hell, /King of the Hill/ so thoroughly tore apart the concept that nothing can nor probably ever will top it. I mean fuck, MIKE JUDGE. How do you out-satire that guy? You just don't. And yet, there will always be…
Sat, Feb 1, 2014
Chances are you're currently coming down from some sort of holiday hangover, so let's ease back into the political stuff softly here, with a little humour and some Bollywood man-candy. As you've probably heard, India reinstated its ban on homosexual sex. Apparently, the Supreme Court was like, "Progress? Nyeh. I'm sure…
Thu, Dec 26, 2013
Thu, May 26, 2011
Sat, Jul 2, 2011
Tue, Aug 17, 2010
Droll sex lib parody
Wed, Feb 11, 2009
YouTube video already viewed more than 250,000 times
Sat, Sep 20, 2008
Over this past summer, when the Queen of Satire, David Sedaris, was in town he graced George Stroumboulopoulos with his presence to deliver his usual razor-sharp witticisms. Also, I don't watch a lot of Stroumboulopoulos (unless he's interviewing Margaret Atwood about dabbling in modernity [1]), but does he always sit…
Sat, Aug 31, 2013


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Beck named America East Rookie of Week
Freshman guard recorded 10 assists, double-double vs. Bryant
December 30, 2013Tweet
Contact: John Hartrick (email@example.com)
VESTAL, N.Y. - After a strong performance in Binghamton's win over Bryant, freshman guard Marlon Beck II has been selected as the America East Men's Basketball Rookie of the Week, the conference announced on Monday. It's the second honor this season for Beck.
In BU's 67-62 win over Bryant, Beck contributed a double-double - his first collegiate - with 10 points and a season-high 10 assists. He added four steals and committed just one turnover in 37 minutes at the point. The 10 assists tied for the highest single-game output of any player in the America East thus far this season.
It was the second time this season Beck has earned the weekly honor and fourth time in seven weeks that Binghamton has produced the top rookie.
Beck ranks fifth in the America East in three-pointers made (1.9/game) and sixth in assists (2.8/game). He is averaging 11.8 points (2nd among AE freshmen) and leads the team in three-pointers (23) and assists (33). Beck is logging nearly 34 minutes per game.


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Howard Hawks loved to undermine the urbanity of Cary Grant, never more so than in this subversive sex comedy dating from 1949.
Grant, disdaining the least attempt at a Gallic accent, plays a French army captain who marries cute US lieutenant Ann Sheridan - only to run full-tilt up against military bureaucracy at its most obtuse. Being the spouse of a US army officer, Grant must by definition be female, a situation that places a billion obstacles in the way of his wedding night. As the comedy of sexual frustration mounts, the hapless Grant is subjected to ever-deeper humiliations until his only hope is to dress up in drag.
Not up there with the director's very best (His Girl Friday, Red River, Rio Bravo), but Hawks always knew how to locate the pain behind rampant farce - just look at the desperation on Grant's face.


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Dr. Petrides has received research support from Amgen, Astra Zeneca, Corcept, Eli Lilly, NIMH, Proteus, St. Jude Medical, and Sunovion, and he has served on an advisory panel for Corcept. Dr. Schooler has received honorarium from Lundbeck, advisory board honoraria from Amgen, Eli Lilly, EnVivo, Janssen Psychiatry, Roche, and Sunovion, and research grant support from Genentech, Neurocrine, and Otsuka. Dr. Malhotra has served as a consultant to Genomind. Dr. Kane has served as a consultant to or on the advisory board or speaker's bureau of Alkermes, Bristol-Myers Squibb, Eli Lilly, Forest, FORUM, Genentech, H. Lundbeck, Intracellular Therapeutics, Janssen, Johnson and Johnson, Otsuka, Reviva, and Roche, and he is a shareholder with MedAvante. All other authors report no financial relationships with commercial interests.
Supported by an RO1 grant from NIMH to Dr. Petrides (MH-603930).
From the Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, N.Y., and The Feinstein Institute for Medical Research, Manhasset, N.Y.
Address correspondence to Dr. Petrides (email@example.com).
Copyright © 2014 by the American Psychiatric Association
17, 2013; Revised
25, 2014; Revised
05, 2014; Accepted
06, 2014.
Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia.
In a randomized single-blind 8-week study, patients with clozapine-resistant schizophrenia were assigned to treatment as usual (clozapine group) or a course of bilateral ECT plus clozapine (ECT plus clozapine group). Nonresponders from the clozapine group received an 8-week open trial of ECT (crossover phase). ECT was performed three times per week for the first 4 weeks and twice weekly for the last 4 weeks. Clozapine dosages remained constant. Response was defined as ≥40% reduction in symptoms based on the psychotic symptom subscale of the Brief Psychiatric Rating Scale, a Clinical Global Impressions (CGI)-severity rating <3, and a CGI-improvement rating ≤2.
The intent-to-treat sample included 39 participants (ECT plus clozapine group, N=20; clozapine group, N=19). All 19 patients from the clozapine group received ECT in the crossover phase. Fifty percent of the ECT plus clozapine patients met response criterion. None of the patients in the clozapine group met response criterion. In the crossover phase, response was 47%. There were no discernible differences between groups on global cognition. Two patients required the postponement of an ECT session because of mild confusion.
The augmentation of clozapine with ECT is a safe and effective treatment option. Further research is required to determine the persistence of the improvement and the potential need for maintenance treatments.
As many as 30% of patients with schizophrenia respond poorly to standard treatment with antipsychotic medications (1). Clozapine is the only medication shown to be effective in antipsychotic-refractory patients (2, 3), but in as many as 45% to 70% of these patients, symptoms are also resistant to substantial improvement with clozapine (2, 4). Limited options are available for individuals with clozapine-resistant symptoms. Several augmentation strategies have been evaluated, including addition of another antipsychotic, mood stabilizers, anxiolytics, antidepressants, and glutamatergic agents; however, no agent has shown unequivocal efficacy in this population. Meta-analyses of randomized placebo-controlled studies have found little or no advantage of augmentation with antipsychotics (5–8). The treatment of this subgroup of patients remains an enormous challenge, with significant public health implications.
Preliminary data from nonrandomized open-label studies suggest that addition of ECT may be an effective alternative for patients with clozapine-resistant symptoms. ECT, while initially introduced for the treatment of schizophrenia in the 1930s, is currently most commonly used for the treatment of depression. ECT and antipsychotics are considered to exhibit synergistic effects (9). In 36 patients with symptoms resistant to typical antipsychotics, Kupchik et al. (10) found that 67% of these patients benefitted from the combination of clozapine and ECT, clozapine, or ECT alone. In an open-label study in 11 clozapine nonresponders, Kho et al. (11) found that the combination of clozapine plus ECT to be efficacious. Havaki-Kontaxaki et al. (12) reviewed all studies of clozapine-ECT combination in schizophrenia or schizoaffective patients with strictly defined clozapine-resistant symptoms, concluding that preliminary evidence exists for the safety and short-term efficacy of this combination. The main limitation of this review was the small sample size (N=21) with data from one open-label trial and six case studies. Finally, Masoudzadeh and Khalilian (13) compared ECT, clozapine, and ECT-clozapine combination in schizophrenia patients with treatment resistant symptoms and noted a Positive and Negative Syndrome Scale score reduction of 46% in the clozapine group, 40% in the ECT group, and 71% in the clozapine-ECT group. They concluded that the combination was significantly better than either treatment alone.
Therefore, our group initiated a pilot study of the effects of adding ECT to clozapine. In an open-label prospective study, we used bilateral ECT to treat 15 patients with schizophrenia who had not responded to clozapine or partially responded to clozapine, despite adequate doses for more than 12 weeks. Nine of these patients (60%) met the a priori response criterion of a 40% decrease in symptom ratings as measured by the psychotic symptom subscale of the Brief Psychiatric Rating Scale (BPRS) (14). Based on these encouraging preliminary data, we have now conducted the first prospective randomized study of the efficacy and side-effect profile of ECT plus clozapine in schizophrenia patients with clozapine-resistant symptoms.
The study was conducted at The Zucker Hillside Hospital of the North Shore-LIJ Health System. The study was approved by the respective institutional review boards, and participants were recruited from the inpatient units of the Zucker Hillside Hospital at Glen Oaks, N.Y., and the Pilgrim State Psychiatric Center in Long Island, N.Y.
In an 8-week random-assignment study incorporating nonblinded treatment and blinded assessments, patients with antipsychotic- and clozapine-resistant schizophrenia were assigned to two treatment groups. One group received treatment as usual (clozapine group) for 8 weeks, and the other received a course of bilateral ECT in addition to their current pharmacotherapy regimen (ECT plus clozapine). Nonresponders from the clozapine group received an open 8-week trial of ECT (crossover trial) with the same schedule and procedures as the randomized ECT plus clozapine group.
Antipsychotic medication resistance was defined as a history of at least two failed trials of 400 mg of chlorpromazine equivalents for at least 4 weeks. Clozapine resistance was defined as a history of persistence of psychotic symptoms after a trial of clozapine of at least 12 weeks, at a blood level ≥350 ng/mL.
The inclusion criteria were diagnosis of schizophrenia according to DSM-IV criteria; age 18–60 years; duration of illness >2 years; resistance to at least two antipsychotics; clozapine resistance; a baseline BPRS score of at least moderate (score of 4) on one of the four psychotic items (hallucinatory behavior, suspiciousness, conceptual disorganization, and unusual thought content) of the psychotic symptom subscale or a score of 12 on these four items combined; a Clinical Global Impressions (CGI)-severity (15) rating of at least moderate (score of 4); capacity to give informed consent; and for women of childbearing capacity, a negative pregnancy test and patient agreement to use a medically accepted form of contraception.
Exclusion criteria were schizoaffective disorder; bipolar disorder; current affective episode; ECT within 6 months; history of epilepsy; severe neurological or systemic disorder that could significantly affect cognition, behavior, or mental status (other than tardive dyskinesia or neuroleptic-induced parkinsonism); psychoactive substance dependence (other than nicotine or caffeine) within 1 month prior to entering the study; a score >18 on the 24-item Hamilton Depression Rating Scale (HAM-D) (16); clinical determination that mood stabilizers that could not be discontinued were necessary; and pregnancy.
We also excluded patients with affective disorders and prominent depressive symptoms because ECT is well known to be effective in those situations, and we wanted to avoid contamination of our results by improvement solely driven by the treatment of the affective symptoms.
The primary outcome measure was response rate. The response criterion was defined a priori as improvement ≥40% based on the psychotic symptom subscale, a CGI-severity rating of mild or less (<3), and a CGI-improvement rating of much improved (≤2). For power calculations, we assumed a response rate of 40% in the ECT plus clozapine group and 10% in the clozapine group.
We chose to define response as a 40% reduction in symptoms based on the psychotic symptom subscale, compared with the traditional 20% in medication studies, recognizing that ECT adds additional levels of complexity and requires increased effort by both clinicians and patients.
Once randomly assigned, participants in both groups remained on the clozapine dose at which they entered the study for 8 weeks. Concurrent use of other antipsychotic medications and antidepressants was allowed as long as they were taken at a stable dose for at least 12 weeks before entering the study. Lorazepam, up to 6 mg per day, or diphenhydramine, up to 100 mg, were used as needed for anxiety, agitation, or insomnia.
ECT was performed with bilateral placement using the Thymatron-DGx device (Somatics, Lake Bluff, Ill.). Seizure threshold was determined at the first treatment. Dosing at subsequent treatments was given at 50% above threshold. The seizure threshold determination schedule and subsequent stimulus levels are shown in Table 1. Medications used during anesthesia were glycopyrrolate (0.1 mg–0.2 mg), methohexital (0.5 mg/kg–1 mg/kg), and succinylcholine (0.5 mg/kg–1 mg/kg). Participants signed a separate informed consent for ECT, and standard institutional procedures for ECT were followed.
ECT was administered three times per week for the first 4 weeks, then twice weekly for the next 4 weeks. If patients met remission criteria before the completion of 8 weeks and showed a plateau in their improvement for two consecutive ratings, ECT was continued weekly through the end of 8 weeks.
Participants from the clozapine group who did not respond to 8 weeks of continued pharmacotherapy received ECT augmentation with the same schedule of treatments and ratings as the ECT plus clozapine group for an additional 8 weeks.
Eligible, consenting patients had a complete baseline medical and psychiatric evaluation. DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV (17) by experienced raters. Patients were rated at baseline and weekly. Final rating assessments were performed at the end of week 8, except those from the cognitive battery, which was administered at week 9 (i.e., 1 week after the last ECT session).
The raters were masked to the clinical assignment. Psychopathology rating measures included the BPRS, CGI, HAM-D, the Schedule for Assessment of Negative Symptoms (18), and the Treatment Emergent Side Effects Scale (15), and rating assessments were performed weekly.
To enhance objectivity, we videotaped the initial (baseline) and final (week 8 or study exit) BPRS ratings. The tapes were edited to remove any revealing statements about treatment, and brief (2–5 seconds), nonessential portions from all tapes were erased to create 3–10 skips in a random fashion, thus balancing the presence of awkward skips that might be otherwise present mostly in the ECT tapes. An independent, masked rater rated the edited tapes. The average score between the two ratings at baseline and the last visit was used for data analyses.
A focused neuropsychological battery was performed at baseline and at week 9. The battery was designed to assess ECT-related effects, as well as measures of cognition relevant to schizophrenia, and included the standard and modified Mini-Mental State Examination (MMSE), the Rey Auditory Verbal Learning Test, the paired-word and story-recall measures subtests of the Randt Memory Battery, the letter-number span task, the Trail-Making Test, the Controlled Oral Word Association Test, the Competing Programs Test, and the Set Shifting Test.
Histograms, q-q plots, and the Shapiro-Wilk test were used to assess distribution of continuous variables. Based on the distribution, an independent-samples t test or Wilcoxon rank-sum test was used to compare the baseline continuous variables between treatment groups. Chi-square test was used for categorical variables. Since missing values may be dependent on the observed outcomes, we assumed the missing data to be missing at random, and hence analysis of the longitudinal data was conducted utilizing a mixed-models approach. A random intercept in the mixed-models was used to account for correlation of measurements over time among the participants; the correlational type was assumed to be unstructured. The difference in slopes of the outcomes between the two treatment groups was assessed using group-by-time interaction term in the mixed models. Interrater reliability between the in-person and video ratings was assessed using both consistency and absolute agreement intraclass coefficients. The consistency intraclass coefficient between the ratings was 0.892 (95% confidence interval [CI]=0.783–0.948; F=17.5, df=28, 28, p<0.0001). The absolute agreement intraclass coefficient was 0.888 (95% CI=0.783–0.948; F=17.5, df=28, 28, p<0.0001). All analyses were adjusted for age.
Participant screening and enrollment flow data are presented in Figure 1 (92 were screened; 54 met inclusion criteria; 13 refused participation; 41 signed consent). Thirty-nine individuals were randomly assigned (ECT plus clozapine group, N=20; clozapine group, N=19). The two groups were well matched on demographic variables, including sex, ethnicity, and psychopathology (Table 2). However, the ECT-treated group was significantly younger than the clozapine group; therefore, all analyses were adjusted for age. Of the 20 participants assigned to ECT plus clozapine, 17 completed the 8-week trial, two dropped out early and refused further ECT treatments, and one was removed from the study because of persistence of involuntary movements. In the clozapine group, 16 of the 19 patients completed the 8-week clozapine phase, and three patients dropped out because they refused to continue to participate in the ratings assessment while there was no change in their treatment. However, all three of the patients who dropped out agreed to participate in the crossover ECT phase, and all 19 participants were included in that phase.
a The p value was calculated using Wilcoxon rank-sum test (p=0.03; W=269).
Ten of the 20 patients (50%) in the ECT augmentation and none (0%) of the patients in the clozapine group met the a priori response criterion. If the less conservative but commonly used response criterion of a 20% reduction in symptoms were used, we would have 12 (60%) responders. Conversely, if an even stricter criterion were used, such as a 50%, 60%, or 70% reduction in symptoms based on the psychotic symptom subscale, we would have nine (45%), six (30%), or three (15%) responders, respectively. None of the clozapine patients would have responded with any of the above criteria. Patients randomly assigned to ECT augmentation were found to have significantly greater reduction in ratings on the BPRS-psychosis subscale and the CGI-severity scale compared with patients in the clozapine group over time (Figure 2, Figure 3). Post hoc analyses revealed that the ECT plus clozapine group had significantly lower psychotic symptom subscale ratings by week 3, and this significant difference persisted for the remainder of the 8-week trial.
a The graph shows the changes in psychosis symptoms in the clozapine group (blue line; phase 1) and the ECT plus clozapine group (red line; phase 1). Treatment-by-time interaction: F=5.38, df=8, 238, p<0.0001. The degrees of freedom for mixed-models analysis were obtained using Satterthwaite's method. Error bars represent standard deviations.
a The graph shows the changes in symptom severity in the clozapine group (blue line; phase 1) and the ECT plus clozapine group (red line; phase 1). Treatment-by-time interaction: F=5.00, df=8, 238, p<0.0001. The degrees of freedom for mixed-models analysis were obtained using Satterthwaite's method. Error bars represent standard deviations.
In the crossover phase, nine (47.4%) of 19 patients met the response criterion. Overall, of the 39 patients who received ECT in the randomized and crossover arms, 19 (48.7%) had at least a 40% reduction in ratings on the psychotic symptom subscale after 8 weeks of treatment.
Regarding negative symptoms, there were no significant differences between the two groups and in group-by-time interactions in analyses with the Scale for the Assessment of Negative Symptoms on global measures for affective flattening (F=0.98, df=1, 39.3, p=0.33), alogia (F=0.03, df=1, 40.1, p=0.87), avolition-apathy, (F=0.76, df=1, 39.3, p=0.39), and anhedonia-asociality (F=1.87, df=1, 39.7, p=0.18). The above analysis was based on actual differences from baseline to final visit. A sensitivity analysis based on percent change scores in the above measures also showed no statistically significant differences between the groups (see table in the online data supplement).
One patient in the ECT plus clozapine group was removed from the study because of recurrence of preexisting involuntary "jerky" movements that raised clinical concerns of seizure activity. These concerns were not substantiated by electroencephalographic studies.
There were no side-effect differences between the two groups in any rated symptom, and there were no treatment-related side effects, except for two occasions when patients in the ECT plus clozapine group were rated as mildly confused and treatment was postponed until the next day.
We did not observe any peculiarities in EEG or motor seizure expression, or any prolonged seizures, during ECT. There were no spontaneous seizures among any of the study patients.
Because of potential concerns about the cognitive side effects of ECT, we included an extensive neurocognitive battery. We assessed multiple cognitive domains, including global mental state, speed of processing, executive function, and episodic memory. The two treatment groups were well matched on each of the neurocognitive variables at baseline, including a global measure of cognitive function (using MMSE).
Neither group demonstrated a significant change in the global neurocognitive measures tested from baseline to endpoint. The mean MMSE scores for the ECT plus clozapine group were 22.6 (SD=1.2) at baseline and 23.1 (SD=1.2) at week 9, and mean scores for the clozapine group were 22.2 (SD=1.0) and 23.4 (SD=1.2), respectively.
Speed measures generally demonstrated significant group-by-time interactions such that the clozapine group improved slightly and the ECT plus clozapine group declined. For tests of visual and verbal memory, significant interaction effects were less consistently found. For executive function (Trail-Making Test, Part B, letter-number span task) interaction effects were not found. Results are presented in the second table of the online data supplement.
In general, our cognitive findings indicate that speed of processing was sensitive to the effects of ECT administration when measured at a subacute time point (i.e., within 1 week of the final 8-week ECT course). Results in the domains involving executive function and episodic memory were less consistently found. Clinically, the degree of cognitive burden shortly after the trial was felt to be consistent with the clinical experience with ECT.
The mean clozapine dosage for the ECT treatment group at baseline was 525.0 mg/day (SD=224.3), and the mean dosage for the clozapine group was 511.1 mg/day (SD=171.0). There were no significant differences between groups. The clozapine daily doses remained unchanged for each patient throughout the course of the study. There were no significant differences between groups in mean plasma levels (clozapine plus norclozapine) at baseline and at endpoint.
The average number of ECT treatments in the randomized phase was 15.8 (SD=4.2), and the average number of treatments in the crossover phase was 14.3 (SD=5.3).
The stimulus dose expressed as "percent of energy" on the Thymatron device is presented in Table 1. The average stimulus levels at the beginning of the course and at the final ECT session are similar to those observed in clinical practice in patients not receiving clozapine.
To our knowledge, this is the first prospective randomized controlled study with masked raters assessing the efficacy of ECT as an augmentation strategy for patients with schizophrenia resistant to or partially responsive to clozapine. The results of this study suggest that ECT is a safe and effective treatment option for these patients and confirm findings from smaller uncontrolled studies and from earlier case reports (11, 12). The response rates of 50% observed in the randomized arm and 47% in the crossover arm compare favorably to all other suggested augmentation strategies for clozapine in this population. The fact that none of the patients in the clozapine group met the response criteria was not unexpected because our selection criteria required a period of at least 8 weeks of clozapine treatment at a steady dose without clinical improvement. The lack of effects with regard to negative symptoms precludes the attribution of response to the improvement of negative symptoms that may often be misinterpreted as depressive symptoms and vice versa.
ECT is the oldest biological treatment used in modern psychiatry. It was introduced as a treatment for schizophrenia in the 1930s, at a time when no medications were available. With the introduction and widespread use of antipsychotic medications in the 1950s, its use in schizophrenia dramatically declined. Yet, there are certain conditions in the course of the illness when rapid results are required, such as cases with prominent catatonic symptoms, suicidality, and agitation or in cases of neuroleptic malignant syndrome (19). In these cases, ECT is used with very good results. In our study, we demonstrated that ECT also may be useful in patients with chronic schizophrenia with positive symptoms not adequately responsive to antipsychotic medications, including the last resort of pharmacotherapy, clozapine.
There are several aspects of our study and its design that are worth mentioning. We paid particular attention to patient selection in an effort to study the effects of ECT on purely schizophrenia patients. We excluded patients with prominent affective symptoms to avoid contamination of our data by improvements driven solely or partially by the treatment of these symptoms that respond to ECT. In order to maintain the blind in a study comparing treatments that are so obviously different, we implemented strict procedures, including videotaping of baseline and exit interviews and independent "off-line" ratings. We included a crossover arm to strengthen the results observed in the randomized phase. Perhaps the most significant element of the study design was our a priori response criterion. We defined response as a 40% reduction in symptoms based on the psychotic symptom subscale, a level twice as high as the traditional 20% used in most medication-resistant schizophrenia trials. This is in recognition of the fact that the administration of ECT adds additional levels of complexity and risk to the treatment of schizophrenia, requires increased effort by both clinicians and patients, and therefore should be met with increased expectations.
The finding that must be emphasized here is that in this group of patients with severe treatment-resistant symptoms, 50% responded with the demanding 40% reduction in symptoms criterion, and 60% responded with conventional response criteria. These are among the highest response rates ever recorded in this patient population.
There were several theoretical concerns regarding the concurrent use of ECT and clozapine, most notably the possibility of prolonged or spontaneous seizures. In our sample, we did not observe any such occurrences. On the contrary, there were instances that required us to administer stimuli at 100% of the device capacity in order to elicit an adequate seizure. This over-time increased resistance to seizure induction is in line with clinical experience and reflects the fact that ECT has known antiepileptic properties causing the seizure threshold to increase over the course of ECT treatment.
With regard to the cognitive effects of the combined treatment, we did not observe any unusual effects of ECT. Our patients were severely ill, and their cognitive performance was, as expected, relatively low, with an average baseline MMSE score of 22. The fact that there was no additional impairment after the course of ECT may reflect the fact that some aspects of cognitive function improved as a result of decreased disorganization, thus counteracting the expected transient memory impairment often seen with ECT.
There are limitations of the study that need to be addressed. First, there was no placebo arm, since sham ECT studies are not considered ethical. Second, the number of patients was relatively low, and our sample included only inpatients. However, this is the largest study of this nature, and the comparative effects between the two groups are very strong. Third, there was an age difference between the two groups, with the clozapine group being older. One might assume that this may make symptoms in this group more resistant to treatment. Nevertheless, all group differences remained significant after correcting for age, and, more importantly, the older clozapine group had an equally strong response to ECT in the crossover phase. Finally, the duration of the study was relatively short and did not allow for conclusions regarding the long-term effects of ECT in this population. As in the case of the treatment of depression with ECT, it is likely that maintenance treatment is required for those patients who respond to ECT plus clozapine, but this should be the focus of further research.
The augmentation of clozapine with ECT for the treatment of clozapine-resistant schizophrenia is a safe and effective treatment option. In this severely ill group of patients with treatment-resistant symptoms, for whom there are few clinical alternatives, we demonstrated a 50% response rate using a conservative 40% reduction in symptoms criterion, and 60% response rate using conventional response criteria. To our knowledge, these are the highest response rates reported with any type of clozapine augmentation. Further research is required to determine the persistence of the results and the need for maintenance treatments.
The authors thank Dr. Max Fink for his contribution to the conceptualization of the study, mentorship, support, and tireless enthusiasm for this line of research.
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I've been waiting for this.
Rep. Paul Ryan has just put out a revised analysis of his new House budget, but this one reflects how his pro-growth tax reform ideas would boost economic growth, which in turn would cut debt even faster. Team Ryan concludes "the budget could achieve balance in the mid-to-early 2020s, with the upper-bound growth assumption producing budget balance within the ten-year budget window – much sooner than CBO's estimated balance date of 2039."
Unlike the Congressional Budget Office forecast, this estimate incorporates solid academic research showing how tax reform can supercharge growth:
House Budget Committee (HBC) staff attempted to illustrate the potential fiscal effects resulting from an alternative growth scenario (AGS). This scenario was meant to capture a range of possible economic outcomes that could be associated with the implementation of the policies in the budget.
For instance, as Alan Auerbach and Kevin Hassett note in their book on fundamental tax reform, the evidence from the broad academic literature on this subject suggest that such a bold reform plan could "eventually increase economic output by between 5 and 10 percent, or perhaps a slightly higher range." Similarly, Columbia University economist Glenn Hubbard suggests that fundamental tax reform could lead to a growth boost of between 0.5 and 1.0 percentage point per year over a decade.
HBC staff first constructed a "base-case" long-term GDP path using a standard assumption that nominal GDP grows by a fixed amount (about 4.3 percent per year) after the ten-year window. Tax reform was assumed to be enacted in 2013 with the economic benefits beginning to materialize in 2015. The alternative scenario was then obtained by applying the growth rule of thumb above to the base case, increasing GDP growth over the subsequent decade by 0.5 to 1.0 percentage point per year and then allowing GDP to ratchet back down to its trend rate in subsequent years.
Under this scenario, GDP growth is significantly higher than the base case over the medium and longer-term. As mentioned earlier, fundamental tax reform would likely boost the supply of labor and the degree of productivity in the economy (through, for instance, more investment and a higher capital stock). By 2030, the level of economic output is between 6 and 13 percent higher than the base case – within the general range mentioned by Auerbach and Hassett.
A larger and faster-growing economy leads to significantly higher revenue than the base case. This higher amount of revenue, when compared to the spending levels outlined in The Path to Prosperity, leads to a much-improved fiscal path. Assuming higher growth within the range cited above – percentage-point increases of 0.5 (lower-bound AGS), 0.75 (mid-point AGS), and 1.0 (upper-bound AGS) – the budget could achieve balance in the mid-to-early 2020s, with the upper-bound growth assumption producing budget balance within the ten-year budget window – much sooner than CBO's estimated balance date of 2039.
Some conservatives have been critical of the Ryan plan because it did not balance the budget quickly enough. I think that complaint has been answered to a great degree, though I would still like to see Medicare reform implemented sooner. But just as important, this analysis show how pro-growth tax reform of the Ryan plan can boost jobs and income and help return America to real prosperity.


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"The Godless would deny and destroy human rights .... the liberties of a nation cannot be secure when belief in God is abandoned.
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Posted on January 21st, 2008 at 5:23 pm
When it's sunny in Florida, it's often snowing somewhere else! So we asked people living in The Villages, Florida what it's like to sunbathe while everyone else is shoveling out. Here's what they told us!
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Snow Park is a Pale Ale that is a refreshing break from the larger products regularly offered in the cold season. Light and crisp with a gentle hint of fine hop aroma, it's a great choice after some fun winter activity at any of our local snow parks. Cheers! Share this:
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