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Corpsman Up: A Tale of Misadventure with Marine's Best Friend
Warning: This story has been pieced together from shitty memory and an erratic idea of the events that took place.
The Navy Corpsman. A token Sailor in the midst of a rabid pack of mongrels. your Corpsman is supposed to be your voice of reason. He's the guy that says "You shouldn't be doing that" on a Saturday night at the barracks when your platoon is shitfaced and piling up mattresses so they can jump off the roof. He's the one that reaffirms your commanding officer's orders that "You should be wearing a condom" when you're about to runoff with a woman that looks like she's been ran through by every Marine on base. He's the one that says "Don't eat that, it'll give you diarrhea" when you're in country and offered food by a local. Do you ever listen to your Corpsman? Rarely. But is he usually right about telling you not to do something? yes. your Corpsman understands the importance of thinking things through before you do them, because he's always the one that has to break into the BAS (Battalion Aid Station) in the middle of the night in order to get IV bags when your friends have brought you back from a night of drunken debauchery and you're almost in a coma. He's the one that has to deal with your impulsive senselessness 24/7—whether it be in garrison, in the field, or on deployment. And even though you choose to ignore his wise words of wisdom the majority of the time, he's always there for you.
One of my Corpsmen, Doc Charlie, knew this routine all too well. if there was any unit in the Marine Corps that could make a responsible person's hair fall out before legal drinking age, it was ours. we had Ski in our platoon for God's sake.
But this story isn't about Ski. It's about Doc Charlie.
Doc Charlie was a first generation Vietnamese-American. like any stereotypical Asian-American, he dressed nice, was well-spoken, probably was too smart to be around enlisted Marines, and always strived for career advancement. As a result of his sensible choices in life, it was really hard for us to get him out to have a wild time with us. It's as if he always had one of those shoulder angel situations going on. you know, where the iconographic cloven hoofed devil (Marine) is standing on one side, saying, "C'mon, Doc, it's just a donkey show in Tijuana, have a little fun," and the winged angel (his domineering father) is standing on the other side, saying, "If you do this, you won't get all A's, then you won't get accepted into medical school, then you won't get a good job, then you'll start smoking crack, then you'll end up living in the ghetto, and then you'll die."
To me, there were no safer people to spend it with than Doc and his good friend (and my gunner) big Sal. Doc had his shit locked down and big Sal had a consistent disposition, himself. Maybe we have a little dinner, get a few drinks, and make it back to ship intact. well, unbeknownst to me, Doc Charlie was going to take this opportunity—away from all the mainland constraints—to completely lose his shit.
To be honest with you, I wouldn't have known what to expect from him anyway. the only times we ever hung out outside of work was when I'd go screaming into his room at awkward hours of the night, complaining to him about the latest disease I thought I had just contracted.
The three of us exited the ship just as the sun was going down, hopped in a cab, and took off to downtown Honolulu.
As we began to make our way down a busy road, I suggested we find a nice local place to eat, "Let's go to Applebee's."
"What?" Doc said with a confused face. "No, Chewy. No fucking food. That's dumb. Let's go into that bar over there."
I never pass up a good idea, no matter how dumb it is.
I think big Sal was the oldest out of all of us, but he wasn't much of a partier. same thing with Doc Charlie. I had just turned twenty-one, so my only drinking experiences previous to this was having my NCOs shove Bud Light down my throat.
We took our seats at a table in the bar and Doc asked the waitress the most important question of the night: "What's gonna get us the most fucked up?"
The waitress seemed a little taken aback by his direct question, "Uh… you'll probably want some Long Island Ice Teas."
"We'll have three Long Island Ice Teas. please hurry," responded Doc.
I remember my first sip. It changed my life forever. It was as if my mouth turned into a Caribbean Paradise (the rum), and a group of Russian Paratroopers (the vodka) and Mexican Vaqueros (the tequila) decided to dance around in a West Side story type of fight scene with an 18th Century British Lord (the gin) officiating the whole thing. Sweet multicultural nectar, it was.
Doc Charlie and big Sal must have felt the same way because they were taking down their drinks faster than a back alley bum. Before the waitress could even make it a few steps away, Doc was ordering more Long Islands.
Now, please remember, we had been under a lot of pressure up to this point. all we had been doing was training for months, and all we had to look forward to was Iraq. This should have been a perfect opportunity for us to engage in some stimulating conversation that would put our minds at ease. But anybody that's ever served in the military knows that the first thing you do when you get a little bit free time is spend it bitching about work and getting yourself even more pissed off.
I think this—based off my own shitty recollection—might have gone on for about an hour or two. the waitresses at the bar were funneling drinks to us like assembly line workers. But since I was getting quite tossed myself, I guess I didn't notice the exact moment when Doc's whole demeanor changed. He just… he just snapped.
I looked over to see Doc, whose face was flushed with red fury, holding the neck of broken beer bottle. He just smashed it into the wall for no apparent reason. Just flat-out rage, I guess.
And that's when the bouncer got called. Not just any type of bouncer, though. No, he was Samoan. I'm talking about the gigantic "I bench press Volvos and eat whole pigs" type of Samoan. Furthermore, he had an overabundance of tattoos adorning his body. I'm not an expert on Hawaiian tattoos, but I know they weren't your standard tribal tats. they looked more like prison tats. we. were. Fucked.
So, what does our Corpsman—our voice of reason—do when he sees this goliath approach us? the motherfucker squares up into a fighting stance.
"When you're a Jet, you're a Jet all the way. from your first cigarette to your last dyin' day."
This looked like it was going to be our dying day.
You know that scene in Indiana Jones and the Raiders of the Lost Ark when that giant boulder is rolling towards Indie as he tries to make his way out of the dark cave with the artifact in his arms? That's exactly what it looked when Sal and I snatched up Doc as the giant Samoan chased us out of the establishment. As we're funneling Doc out of the building, big Sal reached into his pocket and started throwing cash at the bouncer so we could at least have our tab covered. Just a scene of complete mayhem: dollar bills flying through the air, everyone's pissed off at us, and Doc's just laughing his ass off.
We got outside of the bar and ran down the street a few blocks in order to reorganize.
"Dude, dude, we're so fucked. the cops are gonna be showing up any minute," I blurted out.
"Relax, Chewy," said big Sal in his East-LA brogue. "Quit bein' a bitch. we paid the tab. Let's just go to another place."
"I dunno, man. if they call the cops for this we'll be in deep shit."
"Listen, fool. we just got to another place. Nobody's going to recognize us. C'mon, we got another hour or so. Let's just get fucked up."
Then Doc decides to throw his two-cents in by raising his right arm in the air like that never ending story kid while screaming (in the most drunken, child-like voice I've ever heard), "YEAAAAAAAAAAAAAH!"
So we walked a few blocks and arrived at this big hotel patio bar that had an abundance of activity going on. we took our seats in the middle of the action and Doc and Sal—like any good libo buddy would do—ditched me right away.
As they were off trying to find some talent, I just sat there in my own self-pity. there were a few guys up on the stage singing "I come from the land down under" on karaoke and I was just beginning to get that euphoric drunk feeling.
Then I saw her. she was sitting at a table with some of her friends. she had a spectacular exterior: dainty, well curved, perfect tan, great geometric facial features, and an ideal beam. I knew right then and there that she was my Helen of Troy, my Roxanne. But most of all, she had on one of those generic grey "Marines" shirts. I had to have her. This was going to be all too easy.
I approached her in slow motion, like in a cliché 80's rock video. the music was blaring in the background as I closed in. Shafts of light struck her as she chatted with her friends—a perfect aura for my perfect princess. we locked eyes. Sparks began to soar into the air. I knew she was mine.
I took a seat next to her.
Drunk Chewy: "Hey, Sexy."
Hottie: "This is my boyfriend's seat." (She had an Australian accent—my kryptonite.)
Drunk Chewy: "That's hot. What's your name? Matilda?"
Hottie: "Gina. my boyfriend is almos—"
Drunk Chewy: "I like your shirt. Where'd you get that?"
Gina the Hottie: "From a store here in town."
Drunk Chewy: (I leaned in close to her) "I wanna have sex with your voice."
Gina the Hottie: "WHAT?!"
Drunk Chewy: (I instantly recognized our vast language barrier) "I said 'I think you made the right choice.'
Gina the Hottie: "What choice?"
Drunk Chewy: "Your shirt. It's sexy… you're sexy."
Gina the Hottie: "That's very sweet of you, but my boyfriend is going to be coming back and you're in his seat."
Drunk Chewy: "I'm sure he'll be okay."
Gina the Hottie's Boyfriend: (The karaoke song he was singing with his friends had ended and I didn't realize he was standing right behind me) "Okay with what, Mate?"
He was huge, a behemoth of a man. One of those stereotypical Aussie Cro-Magnon looking, roid-raging, Russell Crowe types.
Drunk Chewy: (Startled) "Oh… nothing, Guy. Just havin' a chitchat with your friend."
Gina the Hottie's Boyfriend: "Well, she's my girlfriend and I want to sit down."
Drunk Chewy: (Getting up) "Sure thing, Friend—sure thing." (I then tried to play polite and nice) "So what are all of you doin' in Hawaii?"
Gina the Hottie's Boyfriend: "We just came from Perth and we're going to be travelling across the States."
Drunk Chewy: "Oh, yeah? where to?
Gina the Hottie's Boyfriend: "Los Angeles, Denver, Minneapolis, Chicag—"
Drunk Chewy: "YOU'RE GOING TO MINNEAPOLIS?!"
Gina the Hottie's Boyfriend: "Yes. We're going to a Vikings game."
Drunk Chewy: "A VIKINGS GAME?!"
Now, before I go into this next piece of dialogue, I need to give you a little piece of background on me. Anyone that knows me knows that I get homesick real easily. But I do it in the most hypocritical of ways. for instance, I was born in Los Angeles, California and only lived there for a little bit in my formative years, but when my family moved to Minnesota, all I could do was tell people how great California was and how much Minnesota "sucked." This went on from about five to eighteen years old. then I joined the Marine Corps and was stationed in Southern California for the better part of my enlistment. I was around a group of guys that were from all over the country, but all I could do was go into long rants about how terrible California was and how great Minnesota was. This is the point I found myself in when this story takes place, but I'll go further. when I got out of the Marine Corps, I moved back to Minnesota, and found myself telling people in Minnesota how terrible the state was and that California was ten times better. then I moved down to Austin, Texas where I was telling everybody there that Austin sucked and how great Minnesota and California was. Once again, I moved, this time to San Antonio, Texas. It was there that I told everybody that San Antonio was terrible and Minnesota, California, and neighboring Austin where the best places to be. Now I'm back in Southern California, constantly bitching to everybody about how terrible it is and telling them how great Minnesota, Austin, and San Antonio are. I'm never content with my geographical position. I have wanderlust… and it's a debilitating disease.
When the big roided-out Aussie told me he was going to a Vikings game, I wanted to be his best friend all of sudden. I wanted to be his tour guide through Minnesota, if you will. the company my father works for is right across the street from HHH Metrodome where the Viking play. Parking is terrible around that area—most people have to park and walk quite a distance to get to games, which can be daunting in the Minnesota winter. That's why I've always been blessed to have a place to park for games (at my dad's work). But they're real strict around there, going as far as putting "Private Parking" signs outside of the establishment during game days. the only people who can get in need to work there, be a customer, or know someone who works there. I was going to do this big Aussie a favor. I was going to get my dad to hook him up with some prime parking—not to mention the legendary tailgate parties that go on there.
I whipped out my phone and gave the old man a call, neglecting the fact it was 11 PM in Hawaii, which would have made it 3 AM in Minnesota.
My Father: (Sounding disoriented) "Hello?"
Drunk Chewy: "DAD! DAD! I LOVE YOU, DAD!"
My Father: "Chewy? is that you? What time is it?"
Drunk Chewy: "NEVER MIND THAT! I NEED A HUGE FAVOR!"
My Father: "Are you okay? Did you get in trouble?"
My Mother: (I could hear her voice in the background) "Jerry, is he okay?"
Drunk Chewy: "I'M FINE! I'M HANGING OUT WITH MY BESTEST FRIENDS. THEY'RE FROM NEW ZEALAND OR SOME SHIT! "
My Father: "Yeah?"
Drunk Chewy: "YEAH! I NEED YOU TO GIVE THEM A PARKING PASS FOR THE UPCOMING VIKINGS GAME!"
My Father: "Uh… okay. how will I even know who I'm giving the passes to?"
Drunk Chewy: "EASY! HE'S A BIG MONSTER OF A MAN AND HE'LL HAVE A HOT BLOND WITH HIM!"
Gina the Hottie's Boyfriend: (In the background) "Not cool, Mate!"
My Father: "Sure, Buddy. Sound like you're having a good time. please be safe out there in Iraq."
Drunk Chewy: "DAD, DAD, I'M IN HAWAII! I'M NOT IN IRAQ, YET! IRAQ HAS THE BAD MEN! I'M AMONGST FRIENDS HERE!"
My Father: "Okay, Pal. I'll keep a look out for them. please stay safe."
Drunk Chewy: "OKAY, DAD! I LOVE YOU, DAD! I LOVE YOU, MOM! I'M A GOLDEN GOD!"
I got off the phone with my folks and looked the humangoid Aussie right in the eye, "I just procured your destiny with greatness… you're welcome."
"I didn't ask you to, Mate," he responded.
"You can thank me later."
"Well, if you can't show any appreciation, I'll take my benevolent feelings elsewhere."
I looked right into his girlfriend's eye and gave her an exaggerated wink of the eye. This did not make the big man happy. He was not happy at all.
"AYE, MATE! WE GOT A PROBLEM?!" He screamed at me as he got out of his seat.
I'm not one to seek out physical confrontation, and I never have been. But there was something about having to stare right into his giant midsection that infuriated me—not to mention I was on my way to Iraq, which kind of made me quit giving a shit about petty dangers in American bars.
I scrunched up face, cocked my head back, and went full throttle. I. Was. Going. To. Head. Butt. Him!
I thrust my temple forward. It seems like slow-motion to this day. I could see the gasps on everyone's face. I can still remember the fear in his eyes. I hit.
I got him. I got him right in his left shoulder. Yeah, readers, I was kind of drunk at this point, so my coordination was waaaaaay off. It didn't even faze him. He actually looked at me with confusion.
"WHAT THE FUCK?!" the big mongrel yelled in a baffled manner.
Chewy done fucked up. Chewy had to RUUUUUUUUN! And I did. Totally outmatched, I ran out of that place like Steve Prefontaine on crack-cocaine.
"OUTTA MY WAY!" I screamed as I pushed passed other patrons. "GANG WAY!"
When I got the exit of the bar, I shot a quick glance at the Aussie and his friends. they were just standing there, dumfounded. my getaway was at hand.
I ran through the lobby of the hotel where the bar was located and coincidently saw big Sal and Doc Charlie standing there, struggling to maintain balance.
"Guys, we need to get back to the ship. we gotta go now. I just picked a fight with Crocodile Dundee and he's going to beat my ass."
They were drunk as skunks.
"Yeah," Sal said with a big smile on his face. we walked through the outside of the hotel and were making our way to the exit when Sal, in a moment of drunken impulsiveness, saw an emptied out swimming pool on the hotel grounds.
He looked at it for a moment. Looked back at Charlie and me, then said "Fuck it."
The dude just started tearing off his clothes right there on the hotel property. the shirt came off; the shoes came off, and last went the shoes—which left Sal showcasing his big, beautiful, brown, Mexican body with nothing on but his undies and socks.
"WEEEEEEEEEEEEEE," he hollered as he slid down the 12 foot deep end of the giant pool.
Charlie and I went running up to the edge of the pool where we saw Sal just laying at the bottom on his back, giggling and rolling around like a drunken schoolgirl with Tourettes.
I couldn't help it, it was truly funny. I began to laugh, too.
"BAHAHAHA! Dude—ha,ha,ha,ha—get up! Ha,ha,ha, get up, Bro. we gotta go. Quick!"
Meanwhile, all those Long Islands Charlie had been drinking were starting to come up. I'm on the run for my life, Sal's rolling around in a drained out swimming pool, and Doc Charlie is puking his guts out in the bushes in the corner. This was becoming disastrous.
Doc is bein' all like, "BLAAAAAH," Sal's trying to run and put his clothes on, and I'm convulsing with hysterics as the three of us make our way out to the street corner to get a cab.
Now, this Hawaii we're talking about. And what does Hawaii have a plethora of? Japanese tourists. They're everywhere, like a never-ending locust of disposable income and camera film—that's why I inherently like them: they're really no different from American tourists… except less fat. But the one thing I've always noticed about Japanese tourists is the young males have these annoying multicolored mullet haircuts. I don't know why they do it. Maybe it's not in style anymore, but in the mid-two thousands, mullet mania was big in Japan.
A nice young Japanese girl came up to me as Sal, Charlie (who was still puking), and I were trying to wave down a cab. she was pretty, polite, and doing her best to speak English, so I wanted to help her. But she had a male companion with her, and his stupid haircut was getting on my nerves.
"Excuse me, mista. Do you know where the Diamond Head is?" she asked.
I glanced at her, and then looked at her boyfriend, "Yes, I do. I will grant you your boon my sweet Guinevere of the Orient. But he needs to shave that nasty shit off his head before I answer you."
"Your boyfriend looks like he's from the Ozarks. is there a NASCAR event going on Oahu this weekend?"
She smiled at me, probably not understanding my blatant disrespect for her companion. But I wasn't going to be a complete asshole, so I pointed to Diamond Head on her map and did my best to explain the "We're here, you need to go there" situation.
"Tank you, Mista. Tank you." she said as her and her boyfriend began walking away.
"You're welcome, Helen… you're my Helen of Troy," I blurted out as I stared the smiling mullet-man right in the eyes.
At that moment, big Sal had achieved his objective, "CAB! CAB! WE'VE GOT A CAB! GET IN!"
The three of us hopped in the automobile with drunken enthusiasm. Doc took the front passenger seat and Sal and I slumped into the backseat.
A quick trip back to the ship, shouldn't be problem, right? Wrong. Sal was still rolling around in his own world of hilarity. I was sitting to the right of him in a flaccid, pissed off state. Doc Charlie was directly in front of me, looking like he was ready for another round of puking. the cabbie, a man I'm sure had been used to shuffling drunk Marines around all night, was looking at Doc with that "Oh, please don't puke in here" look on his face.
The cabbie, a middle-aged Asian man, looks at Doc and tries to break the tension.
Cabbie: "You Laotian?"
Let me explain to you what Doc's face looked like when he turned around to answer the cabbie. you know those "Faces of Meth" ads you see at bus stops? the ones that chronicle the before and after pictures of fucked up people as they make their descent into hell over a certain number of years? if you would have taken a snapshot of Doc before we left the ship, and one at this very moment, he could have been a perfect candidate for one of these posters. He just looked flat-out haggard—a look he got in the matter of hours.
He responded to the Cabbie, "No, Vietnamese."
All of sudden, out of nowhere, they just start going into a conversation in Laotian or Vietnamese, I don't know. I don't know what they said, but this is what I saw from the backseat (as Sal was screaming at people on the other side of the car):
Cabbie: "Bạn đến từ đâu?"
Doc Charlie: "Tôi đến từ Phoenix, Arizona."
Cabbie: "Ồ, tôi có gia đình ở Phoenix."
Doc Charlie: "Thật không? Điều đó rất thú vị."
Cabbie: "Bạn trông giống như bạn đang đi để ném trong xe taxi của tôi. Xin vui lòng không."
Doc then leaned his head out the window and hurled a colossal amount of puke outside of the window, which because of the speed we were travelling, caused half of it to smack into my window (Thankfully, I had that sucker rolled up).
He continued with his conversation.
Doc Charlie: "Quá muộn. Tôi nghĩ rằng tôi nhận được nhiều nhất của nó trên mặt đất."
Cabbie: "Một trong những bạn bè mắt tròn của bạn sẽ phải trả tiền cho việc này. Bạn có hiểu không?"
Doc then leaned out of the window for a second time: "BLAAAAAAH!" Heave everywhere.
Doc Charlie: "Vâng, tôi hiểu. Màu nâu dành tất cả của mình trên đảo dài Ice Tea, vì vậymột trong những nhạt sẽ trả. Nâu ném tiền của mình ở Samoa. Xin vui lòng chỉ nhận được chúng tôi trở lại một cách an toàn."
Cabbie: "Được rồi, nhưng bạn phải trả."
Doc Charlie: (Leans out of the window, again) "BLAAAAAH!"
This went on for the whole twenty minute ride back to the ship. By the time we all exited, Doc was heaved out, Sal was wiped out, and I was catatonic. we all looked like shit—and felt even worse.
Cabbie: (Looks me straight in the eye) "Okay, you pay now."
Drunk Chewy: "Why do I gotta pay?"
Cabbie: "Your friend says the white one will pay. Brown one threw all of his money at the fat man."
I slipped him the money for the ride, plus a little extra for the fact that the whole side of his cab looked like someone had thrown spaghetti on it.
Sal and I carried Doc Charlie up the gangplank, through the entire ship, and dropped him in his rack in the berthing. the whole experience had wiped me out. I didn't expect shit to go as crazy as it did when I was with big Sal and Doc Charlie.
Several months later, our ship was carrying us back from the Middle-East and we once again hit up Hawaii—this time as our last stop before our return home.
Doc Charlie comes from the corner of the berthing, "Hey, Chewy, you wanna go out with Sal and I on libo?"
I gave him a ten second stare, "…. Fuck no. I'd be safer with Ski."
Corpsman Up: A Tale of Misadventure with Marine's Best Friend
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Book Description:
The strange and varied lives of the ten children of the world's most beloved novelistCharles Dickens, famous for the indelible child characters he created—from Little Nell to Oliver Twist and David Copperfield—was also the father of ten children (and a possible eleventh). What happened to those children is the fascinating subject of Robert Gottlieb's Great Expectations. With sympathy and understanding he narrates the highly various and surprising stories of each of Dickens's sons and daughters, from Kate, who became a successful artist, to Frank, who died in Moline, Illinois, after serving a grim stretch in the Royal Canadian Mounted Police.Each of these lives is fascinating on its own. Together they comprise a unique window on Victorian England as well as a moving and disturbing study of Dickens as a father and as a man.
Tags: Biographies-Memoirs, Arts-Literature, Authors,

subset: commoncrawl


text:
I'm reading a proposal for a nonfiction book for my internship at a literary agency and all I can think of is this John Green quote:
"I would argue that it is because I have a liberal arts education and because I've spent time thinking about the eyes on that billboard that I'm able to listen to you talk for four minutes about something that I don't understand yet."
While reading this, I can only thank goodness that my English degree taught me to pay attention to the details even when I'm bored. Because otherwise I don't know how I'd be getting through this manuscript.
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text: On Nov 11, 2007, at 12:55 PM, Troop0341 at aol.com wrote: > "P.S. Someday it might be fun to do a re-creation event in which we > re-create the early SCA -- freon can helms, carpet armor, sneering > at fencers, not > letting ladies fight on the Erik, etc." > Robin of Gilwell / Jay Rudin > > "If by fun you mean seeing a rebellion of lady fighters coming at > you armed > to the > teeth, then sure, that might be fun. =)" > -Lady Grainne Kathleen NicPadraig MacDaniel > > As for sneering at fencers... Just how does one sneer at one's > self??? (As > I know there are those out there that started heavy and went light > in their > "mature" years...) :) > Iain MacKay Well, yes. With their excessive pride, strutting and peacockery, I guess that sneering at one's self would be difficult for the rapier fighters. :-) But then since Don Robin has attempted to doing this fencing thing, I assume he thought of that when he was making his original statement. Stefan (and since I seem to be getting mis-interpreted here lately, this is meant to be a joke. Your mileage may very, etc, etc.) -------- THLord Stefan li Rous Barony of Bryn Gwlad Kingdom of Ansteorra Mark S. Harris Austin, Texas StefanliRous at austin.rr.com **** See Stefan's Florilegium files at: http://www.florilegium.org ****


text:
Marilyn Monroe sings several songs for an estimated 13,000 men of the First Marine Division. Miss Monroe stopped at the First Marine Regiment on her tour of the military units in Korea., 02/16/1954
Source: research.archives.gov
Marilyn Monroe sings several songs for an estimated 13,000 men of the First Marine Division. Miss Monroe stopped at the First Marine Regiment on her tour of the military units in Korea., 02/16/1954
"On the eleventh day of Archives an archivist brought to me:
Eleven Marine Corps football players,
ten messengers playing poker
Eight Navy officers
seven of Mrs. Hicks's eight children,
six tiny thorn carvings,
five sisters from Alaska,
four boys hanging out at the Fletcher aircraft school,
three happy girls at a West Virginian celebration,
two San Francisco children painting,
and one astronaut in space."
Image: Eleven football players who have gained national recognition on the gridiron are now undergoing Marine Corps training at Parris Island, SC. They are left to right, Tommy Davis, Duke; Mike Micka, Colgate; Bert Gianelli, Coll. of Pacific; Elmer Jones, Franklin and Marshall; Alex Agase, Purdue; Pat Preston, Duke; Ralph Heywood, USC; (Backfield) Angelo Bertelli, Notre Dame; John Podesto, Coll. of Pacific; Tony Butkovich, Purdue; Mickey McCardle, USC., 05/1942?
With nearly 3,000 pin-ups (including over 200 shots of Marilyn Monroe) serving as wallpaper for their quonset hut, these Marines of the "Devil-cats" squadron are still looking for more, October 28, 1952
Photograph of Three Marine Corps Women Reservists, Camp Lejeune, North Carolina, 10/16/1943
American Indian women too have joined the fighting forces against Germany and Japan. These three are members of the U.S. Marine Corps. They are [left to right] Minnie Spotted Wolf of the Blackfeet, Celia Mix, Potawatomi, and Violet Eastman, Chippewa.
via DocsTeach
Skateboarding Into Combat
LCPL Chad Codwell, from Baltimore, Maryland, with Charlie Company 1ST Battalion 5th Marines, carries an experimental urban combat skateboard which is being used for manuevering inside buildings in order to detect tripwires and sniper fire. This mission is in direct support of Urban Warrior '99, 03/16/1999
Source: blogs.archives.gov
Vietnam….A Marine stands watch in an observation tower as Lieutenant Commander McElroy, the 3rd Battalion, 26th Marines chaplain, holds mass on Hill 950., 07/31/1967
For these dogs of the Marine Corps during World War II, every day was Take Your Dog to Work Day. Read the story of these dogs in "Let the Records Bark."
Then, in addition to providing various basic personal details, each applicant was required to provide answers to a number of personality-focused questions, including: "Are you nervous?" "Gun Shy?" "Storm Shy?" "Do you run away?" "Have you lived in house, or kennel?" "What is your attitude toward strangers?" The only thing lacking is a short essay explaining the applicant's reasons for wanting to join up.
Once accepted for service, the dogs went to the Dog Detachment Training Center at Camp Lejeune, where they were qualified in obedience and at least one other specialty. The record book lists the following possibilities: Guard Duty, Tracking, Attack, Messenger, First Aid, or Draft. In fact, however, most Marine dogs were used for messenger or scouting work.
Image: Butch poses with his handler. Records of the United States Marine Corps, RG 127
Butch the war dog brings Take your Dog to Work Day to a whole new level:
Private First Class Rez P. Hester, 7th War Dog Platoon, 25th Regiment, takes a nap while Butch, his war dog, stands guard. Iwo Jima, February 1945.
Did you bring your dog to work today? Here's hoping your workplace is a bit less hazardous.
(via todaysdocument)
Navajo Indian communication men with the Marines on Saipan landed with the first assault waves to his the beach., ca. 06/1944
The Battle of Saipan began on June 15, 1944. Navajo codetalkers such as these played a crucial role in directing naval artillery during the 24 day battle.
Enacted on June 12, 1948, the "Women's Armed Services Integration Act," allowing women to serve in the military during peacetime for the first time in U.S. history. Although opportunities in the military were still restricted for them, women like Marine Corps Staff Sergeant Hildegard Strobl were now able to serve.
The atomic cloud formed by the detonation seems close enough to touch, and tension gone, Poth and Wilson do a little clowning for the camera, 05/01/1952
Note - The Today's Document staff does not encourage clowning around with atomic clouds…
"Lieutenant Commander Dorothy Ryan checks the medical chart of Marine Corporal Roy Hadaway of Calera, Alabama aboard the hospital ship USS Repose off South Vietnam. Miss Ryan, from Bronx, New York, is one of 29 nurses aboard the hospital ship selected from 500 volunteers of the Navy Nurse Corps." 04/22/1966
Marine receiving first aid before being sent to hospital in rear of trenches. Toulon Sector, France., 03/22/1918
"Men of the 1st Marine Division capture Chinese Communists during fighting on the central Korean front. Hoengsong."
By Pfc. C.T. Wehner, March 2, 1951
Private First Class Rez P. Hester, 7th War Dog Platoon, 25th Regiment, takes a nap while Butch, his war dog, stands guard. Iwo Jima, February 1945.
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text:
Bing Becomes No.2 Search Engine Globally, Still at
suraj.sun (1348507) writes | more than 3 years ago0
suraj.sun (1348507) writes "Bing Becomes No.2 Search Engine Globally, Still at 4.4%
Bing has overtook Yahoo for the first time worldwide in January and increased its lead in February according to web analytics company, StatCounter. Its research arm StatCounter Global Stats finds that globally Bing reached 4.37% in February ahead of Yahoo! at 3.93%. Both trail far behind Google's 89.94% of the global search engine market.
In the United States Yahoo! at 9.74% still retains its lead over Bing at 9.03%. Google's share in the US is 79.63%. In July 2009 Microsoft announced an agreement whereby Bing would power the Yahoo! search and it has been implemented in the US, Canada, Australia, Brazil and Mexico.
Statecounter: http://gs.statcounter.com/press/bing-overtakes-yahoo-globally-for-first-time"
Link to Original Source


text:
Each of the major sites in the park is partially wheelchair accessible and a wheelchair is available for loan at each site.
To make your visit more enjoyable, San Antonio Missions National Park is continually upgrading facilities for greater accessibility. If you have questions or suggestions about facilities not covered in this section, contact: Accessibility Coordinator San Antonio Missions National Historical Park 2202 Roosevelt Ave. San Antonio, TX 78210, or email.
The designation accessible indicates access for wheelchair users in compliance with Uniform Federal Accessibility Standards (UFAS). Information in this section describes only the accessibility of facilities at San Antonio Missions; it is not a complete description of activities and services.
Cellphone Audio Tours - Missions San José, San Juan and Espada have audio tours available through personal cellphones, which can be accessed while you tour the sites or from the comfort of your home. (210) 852-2407 (English) and (210) 857-2408 (Spanish)
Check with a ranger on the accessibility of ranger-led activities. Some activities may require assistance. Inaccessibility may be due to rough terrain, steep grades, or stairs in historic structures.
Mission San José
Did You Know?
The mill at San Jose was in use and grinding wheat by 1794. The mill is believed to be the oldest in Texas. In 2001 President Bush came to San Antonio Missions National Historical Park and dedicated the mill, which is in use today.


text:
City Guide
5 New Places To Eat Incredibly Well In Las Vegas
Sin City has seriously stepped up its dining game
Oct 21, 2014 11:00 am
10 Best Dublin Pubs To Soak Up Irish Culture
Irish capital is awash in Guinness and fiddle tunes
Oct 14, 2014 10:00 am
You Travel, You Eat: Santa Barbara
Where to eat, drink, shop and stay in SoCal getaway
Oct 9, 2014 9:00 am
5 Places To Eat Incredibly Well In Providence, RI
A creative food scene that's not to be overlooked
Oct 2, 2014 11:00 am
5 Places To Eat Incredibly Well in Toronto
Top picks from a top Canadian eating destination
Sep 16, 2014 10:00 am
3 London Restaurants With A Bloody Good View
Eating well while looking down on Londontown
Sep 10, 2014 10:00 am
5 New Places To Eat And Drink Exceptionally Well In Washington, D.C.
Nation's capital is quickly gaining culinary cred
Sep 9, 2014 9:00 am
9 Places To Eat And Drink Incredibly Well In And Around Bologna, Italy
The birthplace of prosciutto beckons
Sep 3, 2014 1:00 pm
A true gourmet must know gormeh. We have proof.
New cookbook aims to debunk edible marijuana myths
Watch out, fancy ramen, KOA's sorba noodles rock!
Britain stops rinsing raw chicken. We should, too.
Introducing the No. 7 Vans Classic Slip-On
Two liters of French 75? Yes please.
Stop everything and start deep-frying scallions
Meet notNeutral, innovators of coffee drinkware
Irish capital is awash in Guinness and fiddle tunes
Breweries use modern packaging to simply make noise


text:
Recently Sold ListingsYou Are Currently Viewing The Archives. These Items Have Been Sold.
View Current Massey Ferguson TO-35.
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text:
Penetration Testing
mailing list archives
I use a tool called stunnel (www.stunnel.org).
You can specify the remote server name and port, as well as the local port
to bind to. Then I start whisker against 127.0.0.1 and the port that I
bound stunnel to. All traffic sent to the local port is redirected over the
SSL session.
-----Original Message-----
From: van Eeden, Stieler [mailto:veedest () EY CO ZA]
Sent: Friday, September 08, 2000 3:24 AM
To: PEN-TEST () SECURITYFOCUS COM
Subject: [PEN-TEST] Scanning through SSL proxies.
Since everybody is starting to realise that SSL is a more
secure protocol
than HTTP ..heh.. A lot of clients is running SSL based webservers.
Unfortunately most make the mistake by thinking if they
implement SSL they
are secure and cant be hacked. But they are actually just secured from
sniffing etc. and then dont bother to harden the OS or
review their cgi
scripts. The attacks can still be automated through a SSL
proxy. Go and
check you could still be vulnerable to RDS :P
Up to now I've done all the checks manually, damn it takes
long! In the
whisker documentation RFP says that it is possible to use an
SSL proxy. I
quote from his documentation (
http://www.wiretrip.net/rfp/p/doc.asp?id=21&iface=2 )
"<> SSL support is officially to be had by using sslproxy by Christian
Starkjohann <cs () obdev at>, at http://www.obdev.at/Products/. It
runs on both Win and Unix, so life is good. Copies are available
from my site just in case you can't find them. RTFM for usage."
I also noted that a few paragraphes before that he stated -
"<> Proxy support has been removed until version v2.0. The
previous proxy
commandline options have been
re-used into
other v1.4 features."
I assume he is talking about normal proxy support.
I had a look at SSLproxy and had a few problems to get it to
work in Linux,
I could be missing a few Libs. I have OpenSSH and OpenSSL
installed. ;/
Apparently there is a win32 port of sslproxy, the link to the
win32 port is
dead. :(
Anyone got a copy ?
Have anybody got this to work successfully ? I need some
help, please give
me some light ! Is there any other SSL Proxies that can be
used to simulate
webscan's ? Up to now whisker look like the only worth while
tool with ssl
proxy support for the job.
By Date
By Thread


text:
Reuters blog archive
from FaithWorld:
GUESTVIEW: U.S. synagogues, churches collect similar donation amounts differently
Synagogue Dues Don't Raise More Money Than Church Gifts By Josh Nathan-Kazis
Which costs more: belonging to a synagogue, or belonging to a church?
A survey conducted by the Forward has found that Jewish and Christian religious institutions appear to raise about the same amount per member, despite the fact that church giving is voluntary and synagogues charge membership dues.
The more than 20 churches and synagogues surveyed by the Forward represent a sampling from a variety of denominations in six cities across America. While there are significant regional and denominational differences, an examination of the aggregate data indicates that the amount raised per individual member is very similar between synagogues and churches. But the level of participation is quite different: While synagogues require roughly the same amount of dues from each of their members, church giving does not appear to be so evenly distributed.
Take Ahavath Achim, a Conservative Jewish synagogue in Atlanta, and Church of the Heavenly Rest, an Episcopal church in Manhattan. The two congregations are broadly comparable: Both serve slightly more than 1,000 middle- and upper-middle class households, have a multimillion-dollar endowment, employ about a dozen people and operate on an annual budget of $2.7 million.
from Raw Japan:
Church attacks shake Kansai
In the minds of many people, religious rivalry could occasionally be expected to spill over into violence in places as diverse as the occupied West Bank or Glasgow's 'Old Firm' football derby.
Japan's Kansai region, home to the world's most renowned Zen gardens and some of the country's finest cuisine, on the other hand, is not generally seen as a tinderbox of religious tension.


text:
Yeah, so, some thoughts from my summer.
[more space in my life, more space in my heart.]
I've been working on minimizing my 'stuff' to 'make more space' for things in life that matter more (like love and peace and happiness) and it's been an interesting process.
All summer, I've been kind of freaking out about moving in with my…
Where is Your Power? »
Ever since I started getting serious about my yoga practice, I have been intent on mastering a handstand. I started yoga without much, if any, strength, but after a few months I could hold plank, move through chatarungas, and hang out in downward dog with relative ease. I was so inspired and…
If any of you yogis haven't checked out my secondary blog…here you go! I am attempting to become more organized and am thus putting most of my yoga/philosophy/food/healthy living related posts on this other blog. Enjoy!
I went to a back bending workshop last weekend, taught by an incredibly knowledgeable and gifted ashtanga yogi, and was able to get into this pose and out with a little support.
The first time I went into it, I was completely enveloped in fear because it almost felt like my back would crack in half! But I did it, and after a few days to rest my muscles I was ready to try again. Tonight was a good time because I was warm from a flow class. It was fearless this time, because I knew I was going to be fine.
My goal would be to try insane stuff like this without that initial fear the first time. That was a foreign experience to me because I have never been scared of a pose before! However, I'm learning to embrace the journey and push my limits, even if I'm not sure I can pull it off.
Making more space for more love. 2014.
While I haven't been focusing specifically on back bending over the year, I have noticed a huge change in the openness of the majority of my back, chest and shoulders. When I compare February (left) to October (right), it's exciting to see how much space I've been able to open up in a year of consistent practice! 2014 is going to be an insane year, if I've already made this much progress!
2013 - Thoughts on Perspective
This year has been a wild ride. I am so thankful to say that it has been a journey of overwhelming happiness, for the most part. Not that it was all marshmallows and roses, though—there have been a lot of opportunities to change and grow as a person in there, too, and for those I am the most thankful.
Every year I sit down and look back over my life, utilizing that poetic "hindsight is 20/20" concept to hopefully shed a little light on why I am here. Every year I realize that I still don't see the entire picture, as much as I long for a completely balanced perspective on myself, but I am given little pieces of truth that continue to help me figure out the puzzle. Yes, I know this will be a life-long process. No, my goal is not to know everything about everything, or even about myself. Instead, all I'm really hoping to do is use the truth I have been given by God to create more space to fill with more love, because if I have nothing else at the end of a season, I know I will have that, and it's enough.
My main focus over 2013 was maintaining a healthy perspective in every situation in life. Obviously I knew this was not going to be without challenges, but wow, was it harder than I expected. I had a few pivotal moments where I was nursing a great stress tornado, only to suddenly be called back by this little poke from within that reminded me, "Hey, you brought this on yourself. Change your perspective, change your situation." Within minutes, I'd sit there dumbfounded at how trivial my issue was when I looked at it from the right perspective.
Ultimately perspective stems from a foundation of faith. Everyone believes in something, whether they admit it or not. Belief builds our culture and shapes us not only as a whole, but as individuals.
"What is the eternal power in a human being? It is faith. What is the expectancy of faith? Victory—or as Scripture teaches, that all things work together for the good of those who love God. Faith is an expectancy of the future that expects victory. Faith conquers the future. The believer, therefore, is finished with the future before he begins the present, and this victory can only make him stronger for the present work." - Soren Kierkegaard
And so I learned and I grew, a lot more than I realized after I looked back over this year, which continues to amaze me, and I had this perfect, neat little essay written up about all the nuggets of truth I've acquired through this journey towards discovering perspective. But the year isn't over yet, and in the last three days I have completely rewritten a month's worth of work into this much more realistic, not as eloquently presented, account of my journey, because I didn't actually get the plot twist on this story until today: The healthiest perspective can be found by being present.
That's right. There isn't any magical "will this matter in two months" formula for peace of mind and a reduced-stress existence. In order to get past the hard stuff, you need to actually go through it, and not try to escape it or pull out some meditation that will make it easier or less uncomfortable. You just need to put your feet on the ground where you are, take a deep breath and move forward. Face all those fears and pains and triggers, and make yourself get inside them and figure out why they are the way they are, whatever that means for you. Only then will you finally have the perspective Kierkegaard was talking about above: The victory is already won. There's nothing left to worry about. And then you will realize what you can do to keep going, because you'll know without a doubt that life will keep moving forward, and you need to stay in the present, where it's happening and where you have the choice of how to react to your environment. You need to do the present work to gain the perspective you need for your future.
Realizing how much I have adapted to unconsciously applying this philosophy has shown me the extent to which I've changed as a person in the last year. It's changed dynamics in my priorities and relationships for the better. It's certainly changed the way I move through my life; I approach opportunities with less fear and more ambition than I used to. I'm learning what to let matter and what to let go of. I am learning how much there is in life to absolutely love, and how to make room for more of that day-to-day.
With that being said, I am content with how my story is going so far. I'm so thankful to the people in my world who have walked with me through some crazy times in my life this year. God has given me so many opportunities to be challenged, open up, and share love, and that's always an good thing.
Thanks for taking time to read what's been on my mind and heart as we go into the next year. I hope you continue growing in your walk through life, whether you are lengthening the same path or starting a new adventure. Feel free to share what you've learned over 2013 in my ask! I'd love to hear it!
(February 2013-October 2013 progress. Sometimes you don't realize how much you've grown until you look with perspective!)
I just listened to two ads, consecutively, about energy shots and energy pills.
Life tends to get hectic over the holidays, but that doesn't mean you have to drag along dependent on caffeine! Here's a few tips to boost your energy effectively:
- Drink enough water. Water keeps all the 'circuits' connected in your body.
- Avoid excess sugar, caffeine and alcohol.
- Sleep enough! Nothing really compensates for a full night's sleep.
- Rest when you can. That one loose end can probably wait an hour while you take some time to breathe.
- Get your feet up. At the end of the day, nothing helps revitalize your body like getting the blood going in a different direction.
Here's a crazy arm balance I tried this summer and couldn't accomplish. I forgot about it and suddenly remembered it last night when some folks were playing around after class, and surprise! Nailed it on the first try!
Pics are from tonight. Naturally yesterday I forgot to document my moment of triumph.
Last night I was spontaneously taken out, to chill at a bar pretty close to my place, by this handsome manly man holding my heart.
Bars do not have good lighting for self-indulgent attempts at adorable couple shots.
Who cares. I have no complaints. Life is beautiful, I am secure, and my future is slowly unfolding in front of me more every day.
I'm enjoying the journey. So much change and growing.
Happy weekend, folks :)


text:
Animal & Veterinary
Risk Standard for Food Additives
SLIDE 1: CVM Workshop on the use of Antimicrobial Drugs in Food Animals January 23, 2001
FDA's Risk Standard for Food Additives and FDA's Threshold of Regulation for Food Contact Substances
Mitchell A. Cheeseman
SLIDE 2: Summary
- Standard of Review
- Standard of Safety
- Threshold of Regulation
- Legal basis/ History
- Scientific basis
SLIDE 3: Standard of Review
"Fair evaluation of the data . . ."
SLIDE 4: House of Representatives, Report No. 2284, "Food Additives Amendment of 1958"
Committee on Interstate & Foreign Commerce, 85th Congress, 2nd Session, July 28, 1958
"The committee feels that the Secretary's findings of fact and orders should not be based on isolated evidence in the record, which evidence in and of itself may be considered substantial without taking account of the contradictory evidence of equal or even greater substance . . . ."
SLIDE 5: Standard of Safety
The petitioner has the burden to demonstrate a "reasonable certainty of no harm" from the intended use of the additive
This requires that the FDA assess whether it has received adequately documented answers to appropriate questions of probative value.
Legislative History of the FD&C Act
The concept of safety used in this legislation involves the question of whether a substance is hazardous to the health of man or animal. Safety requires proof of a reasonable certainty that no harm will result from the proposed use of an additive.
It does not -- and cannot -- require proof beyond any possible doubt that no harm will result under any conceivable circumstance.
- It is NOT an academic inquiry or academic research
- It is NOT a search for "complete knowledge"
- It is NOT intended to ensure, nor is it possible to ensure, safety
with absolute certainty: ("Reasonable Certainty of No Harm"
rather than "Certainty of No Theoretical Possibility of Harm")
- Does NOT weigh risks and benefits
- It DOES, in fact, ensure safety
- It IS a consensus decision made under uncertainty that provides a fair evaluation of all the data of record …
- That must protect the public health
- That is made in the absence of complete knowledge
- That will withstand scientific, procedural, and legal challenge from all sides
- Where the residual uncertainty is not out-of-line with what has been previously tolerated in the context of all previous similar safety decisions
SLIDE 9: Food Additive Definition
The term "food additive" means any substance the intended use of which results or may reasonably be expected to result, directly or indirectly, in its becoming a component or otherwise affecting the characteristics of food.
SLIDE 10: Threshold of Regulation Proposals
- Frawley 1967
Dietary Conc. of 100 ppb
- Ramsey 1969
Migration of 50 ppb
Migration not detectable (50 ppb)
Dietary Conc. of 0.5 ppb
SLIDE 11: FDA's Threshold of Regulation
- Threshold for review not approval
- 0.5 ppb in the diet
- No specific testing required
- Compound must not be known to be a carcinogen (Delaney)
- No technical effect in food
SLIDE 12: Problems with Establishing a Threshold of Regulation Policy
- Uncertainty in the amount of flexibility FDA has in interpreting the food additive definition of section 201(s) of the FD&C Act.
- Absence of data showing that substances present in the daily diet at concentrations at or below the proposed threshold level would not pose safety concerns.
SLIDE 13: Monsanto v. Kennedy
613 F. 2d 947
(D.C. Cir. 1979)
The Monsanto court held that "… the Commissioner may determine, based on the evidence before him that the level of migration into food of a particular substance is so negligible as to present no public health or safety concerns…"
SLIDE 14: Dietary Concentrations at Which Noncarcinogenic Toxic Effects Occur
- Frawley, 1967
- 1000 ppb (220 Chronic studies)
- Rulis, 1990
- 1000 ppb (18,000 acute studies)
- Cheeseman, et al., 1998
- 98.1% > 500 ppb (3,306 reproductive toxins)
- 99.9% > 500 ppb (2,542 subchronic studies)
SLIDE 15: The Problem of Carcinogenic Risk
- Can we be reasonably certain that an untested compound is unlikely to be both:
- A carcinogen
- Potent enough to be of concern at a given dietary concentration?
SLIDE 16: A Probabilistic Approach
- Use a database of compounds of known carcinogenic potency that is representative of unknown compounds. (Gold CPDB)
- Perform a probabilistic analysis of the doses equivalent to a negligible risk level. (I.e., one in one million U.B.)
SLIDE 17: Threshold of Regulation
Graphic Image


text:
Get your popcorn ready.With genius work like "Bad Teacher," and "Big Brother 13" on the screen, we at Short Order think you need a drink. So check out the top ten weirdest, most outlandish, and highest "grossing" drinks in movie history.
The Bourbon Room?A few years ago, Jason Handelsman wrote: "The outskirts of Miami's Overtown hood are becoming a gentrified version of the Sunset Strip in LA." And now it's actually happened. New Line Cinema is shooting the film adaptation of a hit Broadway musical called Rock Of Ages entirely ... More >>
It's Noël hell, really.
Shoot 'Em Up proves its star could have been a killer Bond
DVD releases for the week of January 9, 2007
Eerie melodrama explores the dark arts in turn-of-the-century Vienna
Boy turns bug in redemptive kiddie-lit adaptation
M. Night Shyamalan steps up the lunacy with Lady in the Water
Your three-month forecast of the summer's top movies
Some interesting horror flicks, a couple of relationship movies, and plenty of action save summer from sequels
In a year when small movies came up big, picking the best was a Payne
A bitter wine freak makes an adorable hero in Alexander Payne's Sideways
Could it be that this year's crop of summer movies actually requires a brain cell or two?
Storytelling continues Solondz's bluster of sex, rage, and insanity
Big Momma's House
Man on the Moon


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text:
Thanking My Lucky Stars!
I just got notified that I won a scholarship for Full Tuition for all of next school year! I can't believe that I actually got this scholarship. I can't even express how relieved I am, this is going to help so much. Especially with the husband's med-boarding process starting!
It still hasn't sunk in yet!@1 year ago with 3 notes
#thankful #scholarship


text:
Full Disclosure
mailing list archives
Message: 12
Date: Thu, 17 Apr 2008 16:51:56 +0100
From: n3td3v <xploitable () gmail com>
Subject: Re: [Full-disclosure] Web Application Security Awareness Day
To: full-disclosure () lists grok org uk, n3td3v
<n3td3v () googlegroups com>
<4b6ee9310804170851p6514245dq47d7f82ac3db37d0 () mail gmail com>
Content-Type: text/plain; charset=ISO-8859-1
What the hell are you talking about? How does that have anything to do
with what Taneja said?
it means people will be posting web app sec bugs on may the 1st,
regardless of what n3td3v enemies say.
Where might one watch? What channel? Which list! I am looking forward to the
action and interesting day.
Full-Disclosure - We believe in it.
Charter: http://lists.grok.org.uk/full-disclosure-charter.html
Hosted and sponsored by Secunia - http://secunia.com/
By Date
By Thread


text:
- You are here:
- mitsubishi cars
mitsubishi cars
Arnaud Montebourg (pictured), French Minister of Industrial Recovery, was recently the target of a rather despicable slur at the hands of Mitsubishi France's leader, Jean-Claude Debard. Frustrated by Montebourg's attempts to encourage the purchase of lower emitting vehicles and discourage use of ...
Believe it or not, Mitsubishi sales in the U.S. are up in 2011 – by a whopping 53 percent. But while the automaker's sales are climbing out of the doldrums, its executive count is dropping. Automotive News reports that two key executives have resigned effective October 31, and those vacancies ...


text:
Search pictures and profiles of Senior Singles near you right now. Discover how online dating sites make finding singles in the United States, Canada, and all over the world simple, safe and fun! Once you browse profiles and pictures start flirting, messaging and connecting with other members of the SeniorPeopleMeet.com community. Search today and find other sexy, intelligent singles for casual dating or a serious relationship in your area.Search Single Senior Men | Search Single Senior Women
A little about me...
I cherish life, love to share, enjoy companionship, boat , hike and ski a lot and am independent, also am a bit of a vagabond. I can pack in 15 minutes for a two week trip and if trail changes, I'm in! If you need to shop for 2 weeks prior to a fortnight in Alaska, enjoy your shopping, I'll be in Alaska or the Virgin Islands or New Zealand.
About the one I'm looking for...
waiting for Kind, compassionate woman that loves herself enough to love others.
I'd just like to add...
Send me a message.
Meet Senior Singles
in your State


text:
The Walking Dead tells the story of life following a zombie apocalypse. It follows a group of survivors, led by police officer Rick Grimes, traveling in search of a safe and secure home.
Aired: February 17, 2013
The group debates the next step; Rick searches for a lost friend; Daryl and Merle question their choices; the Governor restores order.


text:
Breaking Bad - Hazard Pay
The new cooking plans are devised. This time they are going into homes that are being tented for pests and making a batch. Crazy idea, but it just might work! Remember that Malcolm In The Middle where their house was tented? Walt and Mike have an argument about money! Walt watches Scarface with Jr. Foreshadowing much?


text:
Since Youtube upgraded their layout design, it was time our channels get a makeover! Here are some layouts I've designed for comedian Chengman, singer Jordan Lorenzo of Nu-Lite Entertainment and myself.
It was a fun challenge since each Youtuber has a different personality and image to project. Hopefully I'll get new Youtube clients soon to design more layouts! :]
- koreyanka likes this
- dannytranlx likes this
- tonytranlive posted this


text:
1957 Ford Thunderbird barn find, factory black car with red interior, 312 V8 automatic, power steering, power brakes, power windows, power seat, and both... More
The Truck runs great. It does need a radiator that costs 700. Its a beautiful Truck. So fun to drive... More
2000 Ford Mustang Convertible, Green with tan cloth interior, Black top, V-6, 5 Speed, New clutch. Runs and Drives well. Needs brake work and... More
This vehicle is in the Michael Dezer Collection that will be offered up for auction.It has been in a climate controlled environment for many... More
1965 Ford Flatbed Pick-Up I would consider it to be in fair to good condition Rust free cab Original paint to my knowledge (has typical oxidation on the... More
1964 1/2 Mustang Convertible Wimbledon White / Blue interior and top 260 V8 automatic , 67000 original miles garage find, 2nd owner, parents purchased in 1982, stored... More
1968 Ford Ranchero. Driver. White with flat black hood accent. Re-painted 10 years ago. Paint is in fair condition. Factory 302 V-8 with factory... More
1966 Ford Thunderbird Town Landau, Good driver, starts easily and runs and drives well. Needs lots of TLC. Body is good, some bondo before... More
1965 Ford Mustang Convertible - 289 V8 "C" code, automatic, power steering, power brakes, power top, factory pony interior, AM radio - Stock &... More
Partially restored running and driving Falcon Ranchero. Recent paint and a great starting point for a project - Or just drive as-is.... More
Ford F100 4x4 1969 Arizona Survivor, Daily Driver, 122,000 Miles, V-8 360, 4 Speed, 4x4 w/Locking Hubs, This Truck Shows Normal Usage and Wear,... More
1965 Mustang Coupe V8 289 that can be made into a driver. The car is green with a tan interior and it comes with... More
1969 Ford Thunderbird 2DR Coupe, All original, 429 V8 w/ automatic transmission, Red w/white top,Red interior, 85,000 original miles 1969 w/ Low Original Miles, Full... More
1931 Ford Model A - rare Sports Coupe. Located in Pawling, NY Owned since 1959 Permanently garaged since 1987 Needs work but everything is there to fully restore. Give me... More
Straight off the farm, this is a 1964 Ford F350 with a 292 Y-block and a 4 speed manual transmission. The motor has been... More
Ford 1956 Fairlane Sunliner Deluxe, long lay-up, needs total restoration, M-code package, extra nice quarters, doors; weathered seats and floor, originally black, straight, complete,... More
Ford 1961 T-Bird Convertible Another barn find! This car has had the same owner for 30 years.The car was actually stored in a dry southern building... More
292 V8, Warner T98 4 speed trans. Engine was balanced when rebuilt. New naugahide seat covers. New rubber floor mat. Needs some work, tires, and paint. 3"... More
A Barn find! A classic T Bird you can cruise while you fix it up. This one has a 292 V8 backed by an... More
1971 Ford Mustang Convertible, 302-2V Automatic transmission. The car has had the same owner since 1972. All Original drivetrain, the engine and tranmission have never been... More
1971 Ford Bronco Half Cab Pickup, 6 cylinder, 3 speed manual column shift, Working 4 wheel drive, locking front hubs, Heavy duty bumpers front... More
1976 Ford tow Truck, Gray, Black steel body, 390 V8, 4 speed manual transmission with dual speed rear axle, Good brakes, and suspenson. Runs... More
A nicely modified 1988 Ford Mustang with blue exterior paint, Cragar chrome wheels and an after-market sunroof. The interior is blue cloth and leather, with... More
A 1970 Ford Thunderbird with brown exterior paint, white vinyl top and aluminum wheels. The interior is brown vinyl and cloth. The engine is... More
1937 Ford 2 door trunk. This car was in the same family in Mississippi until the late 1990's. Engine was rebuilt and runs and drives... More
1964 Ford Custom Tudor (Model 62E),just retrieved from lengthy storage,with new brakes,shocks,gas tank,battery,tune up,radial tires,etc.,but still awaiting exhaust.This "no frills" model is quite solid,needing... More


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Glade linen room spray
£1.23 (41p per 100ml)
10% off Everyday lines Brand Price Match - Checked Tesco.com 27/10/2014
Product Summary
Eliminate odours. Freshens the air. Acts in seconds. Quality fragrance. Long lasting freshness. SC Johnson. A family company since 1886. Fisk Johnson
Usage Instructions
- Shake can well. To freshen the air, point can towards centre of room and spray. This product is not recommended for use on fabric. Extremely Flammable. Keep out of the reach of children. Keep away from sources of ignition - No smoking. Do not breathe spray. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Use only in well-ventilated areas. Caution: Use only as directed. Pressurised container. Protect from sunlight and do not expose to temperatures exceeding 50°C. Do not pierce or burn, even after use. Do not spray on a naked flame or any incandescent material. People suffering from perfume sensitivity should be cautious when using this product. Air fresheners do not replace good hygiene practices. . Solvent Abuse Can Kill Instantly
Please note that whilst we take every care to ensure the product information displayed on our website is correct, product recipes are regularly changed and this may affect nutrition and allergen information therefore you should always check product labels and not rely solely on the information presented here.If you require specific advice on any Waitrose branded product, please contact Customer Support on 0800 188884 or email firstname.lastname@example.com. For all other products, please contact the manufacturer.This information is supplied for personal use only. It may not be reproduced in any way whatsoever without the prior consent of Waitrose Limited nor without due acknowledgement.


text:
I've found myself in a few conversations lately with some big, strong guys who are sort of feeling stumped when they're at the gym. They've been doing the same exercises for years and years, and don't really know how they should be switching it up (many just hate to admit it and ask for help – which is of course why I start digging). So, they hobble around from the lat pulldown machine to the leg press, from the bench to the roman chair, and finally when they run out of ideas they leave the gym feeling certainly more depleted than pumped up. What's missing? A solid circuit structure. Circuit style training is amazing for you men...Read More
People might think it sounds kooky, but having a strong core relates directly to one's confidence level. The core is the power centre – responsible for all of our limb movement. It is the source of our movement, just as confidence is the source of our progressive capabilities in life. So, by strengthening our cores, we strengthen our confidence, and confidence takes care of attaining what we deserve and what we need to be most successful and happy in life. So, is your trunk feeling balanced and strong right now? And are you, then, feeling strong and confident? I like for clients to check in on this. When you properly engage your core, it changes the...Read More
Listen – I'm going to be very honest. After having some time off – time filled with lethargy, laziness and food comas – getting back in the swing of a routine can feel like pushing a boulder up a very steep hill. Going from elaborate celebratory breakfasts back to oats, flax and berries (although to be honest that sounds pretty great right now) is not always easy. I always tell my clients that we snowball in both directions, yet the unhealthy way is steadfast downhill, and the healthy adjustments are heavier and uphill. This is because, well, sugar and fats are addictive. The industries do it on purpose, right? Most of us know this by now. ...Read More
Duh! This is my very favourite fitness-related thing. The Bosu is my favourite fitness toy / tool. I use it in so many sessions, because I am a firm (pun intended) believer that stability work, combined with some soft-landing plyometrics, is the fastest way to get a hard body that is endurable from the inside-out. If you have a Bosu, with proper guidance you can do an amazing full-body workout with strictly bodyweight – no dumbbells required. Stability challenges require optimal muscle recruitment, and strengthen those suckers right down to the bone. Read: you will achieve a strong, long-lasting and compact body. Where do you buy it? Again, I recommend Foremost...Read More
The absolute best do-anywhere, heart-pumping fat-blasting and anatomy-respecting cardio? Jump rope! If you haven't tried this since you were a kid, it's time to pick the rope back up and give it a whirl. Be patient with yourself, it can take a few tries to get back in the "swing" of it. Start with 30-50 jumps, work your way up to 100 using it in between your strength circuits. Soon enough, you'll be able to blast out 5-10 minutes at a time. Then, you can simply take a few breaks and use it as an entire cardio workout. The other reason I love it is the body stays pretty straight, so the hip flexors don't get the same constant...Read More


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Posted on July 11th, 2014
Amsterdam's New RAI Amtrium Conference Centre Opens with Vertical Garden in 2015
Posted on July 7th, 2014
7 Reasons to Meet in Stockholm
A compact yet cosmopolitan city with excellent flight connections and an efficient public transportation system, Stockholm offers modern venues, great accommodation, spectacular scenery and lots of social activities.
Posted on July 2nd, 2014
Why Ireland Remains One of the Best Values in Western Europe
"For the last few years, Ireland has had one of the lowest, if not the lowest, tax rates in the region."
Posted on June 23rd, 2014
London's New Shangri-La Hotel Has Best Meeting Room View in Europe
The new Shangri-La Hotel at The Shard, London, officially opened this spring in the South Bank, topping out at a jaw-dropping 1,004 feet high.
Posted on June 23rd, 2014
London's Edgy Shoreditch 'Hood Anchors New Tech City UK Development
Shoreditch is part of a growing trend worldwide revolving around the rise of the high-tech, interdisciplinary "smart city."
Posted on June 17th, 2014
Glamorous, Affordable Monaco
Accessible, glamorous and, above all, affordable, Monaco is one of the world's most attractive destinations.
Posted on May 21st, 2014
German Convention Bureau Says International Meetings Continue to Soar
From 2006 to 2013, foreign attendees participating in German meetings and events jumped from 14.3 million to 23.4 million.
Posted on May 9th, 2014
A Lazy Lunch at Bouchon Bistrot in Monte-Carlo, Monaco
It's all very perfect, located across the street from the Mediterranean Sea within walking distance to the Grimaldi Forum Monaco convention and exhibition center
Posted on May 9th, 2014
New Swiss Tech Convention Center Opens with Convertible Theater/Ballroom Space
The amazing new $255 million facility is redefining the idea of "flexible meeting space."
Posted on May 6th, 2014
CityCube Convention Center Opens in Berlin, Replacing Iconic ICC For Now
After years of anticipation, visitBerlin Convention Bureau announced the opening this week of the new CityCube Berlin on the grounds of the venerable ICC.


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NVDAILY.COM | Local News
Posted February 23, 2012 | Leave a comment
Board opts against real estate tax hike
Supporters of rate increase cited need to raise salaries for government workers
By Alex Bridges -- email@example.com
WINCHESTER -- A split Board of Supervisors chose not to raise the real estate tax rate in Frederick County.
Supervisors voted 4-3 at a work session Wednesday in favor of advertising a levy equal to the current rate of 54.5 cents per $100 of assessed value. By law, supervisors can set the rate at or below the advertised levy once they hold a public hearing on the matter. Supervisors cannot approve a levy over the advertised rate.
Supporters cited a need to raise salaries for government and school workers, replace law enforcement vehicles and pay for capital initiatives delayed over the years. Supervisors Gary Lofton, Chris Collins and Ross Spicer voted in favor of advertising the 5-cent rate increase, with the option to approve a lower levy.
Homeowners would have paid an average $103 extra per year under a 5-cent rate increase. The change would have brought the county an additional $3.75 million in revenue.
Opponents said they didn't want to place an extra financial burden on residents and business owners still struggling through a bad economy.
The board voted to advertise the rate under a scenario offered by staff that assumes a proposed fiscal 2013 budget of $127.18 million. The amount includes $1.3 million in additional revenue and represents an increase over the current spending plan of $125.85 million. The proposal also would use $4.3 million from the county's reserves to balance the budget.
School officials explained employees would see a net decrease in salary because they need to pay a 5 percent increase in the contribution to the Virginia Retirement System.
Sovine's proposed budget did not include a pay raise for staff. To do so required increased revenue from the state or the county.
Copyright © The Northern Virginia Daily | nvdaily.com | 152 N. Holliday St., Strasburg, Va. 22657 | (800) 296-5137


text:
Rich plant emollients plus volumizing Wheat Protein' Vitamin E' Guar' Calendula and Rosemary condition hair while building volume from root to tip for thicker' fuller body.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose' treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Aloe Barbadensis Leaf Juice (1)' Aqua (Water)' Glyceryl Stearate SE' Caprylic/Capric Triglyceride' Helianthus Annuus (Sunflower) Seed Oil (1)' Cetyl Alcohol' Stearic Acid' Stearyl Alcohol' Olea Europaea (Olive) Fruit Oil (1)' Calendula Officinalis Flower Extract (1)' Chamomilla Recutita (Matricaria) Flower Extract (1)' Dioscorea Villosa (Wild Yam) Root Extract (1)' Rosmarinus Officinalis (Rosemary) Leaf Extract (1)' Styrax Benzoin Resin Extract' Butyrospermum Parkii (Shea Butter) (1)' Cedrus Atlantica Bark Oil' Citrus Aurantium Dulcis (Orange) Peel Oil' Citrus Limon (Lemon) Peel Oil' Copaifera Officinalis (Balsam Copaiba) Resin' Coriandrum Sativum (Coriander) Fruit Oil' Geranium Maculatum Oil' Lavandula Angustifolia (Lavender) Oil' Pogostemon Cablin Oil' Rosmarinus Officinalis (Rosemary) Leaf Oil' Simmondsia Chinensis (Jojoba) Seed Oil (1) ' Hydrolyzed Wheat Protein ' Sorbitol' Tocopheryl Acetate' Alcohol (1)' Benzyl Alcohol' Potassium Sorbate' Sodium Benzoate' Limonene' Linalool
(1) Certified Organic Ingredient
• Certified by QAI to NSF/ANSI 305' the American National Standard for personal care products containing organic ingredients
• Contains 70% organic content
• No parabens' harsh preservatives' synthetic colors or fragrances' phthalates or harmful sulfates
• 100% vegetarian ingredients
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Massage into freshly cleaned hair' leave in for a minimum of 1-3 minutes to lock in volume' then rinse.
Consult a healthcare professional before use.
Allergy / Dietary Needs
- Organic Product
- Paraben Free
- Preservative Free
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- Phthalate Free
- Sulfate Free
- Vegetarian Product
- No Animal Testing
- Sodium Laureth Sulfate Free (SLES)
- Sodium Lauryl Sulfate Free (SLS)
- Made In The Usa
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One game, one good thing.
March 31: the Blue Jays lost 9-2 to the Rays in their opener (oof), but Erik Kratz hit a two-run homer on his first-ever pitch as a Jay to break the shutout.
April 1: a lot of things were good in their first win of the season, but Drew Hutchison totally ruled.
So Jose Reyes will lead things off as we get set to begin Spring Training 2014, and the first pitch is … in there for a called strike one.Nice to be back.
I never knew Roy Halladay as a Blue Jay.
It seems blasphemous to admit this, as if I carry a Blue Jays fan badge which will be revoked at the mere suggestion that I didn't see every single one of his starts. I saw none of them. Nothing until a year after he'd been traded to the Phillies, when I watched him start the All-Star Game and lose in the playoffs to Chris Carpenter. The trade itself, back in 2009, was one of the first baseball events I ever actually noticed— it was the talk of the town, obviously, and I had almost no idea who he was.
Sometime after the 2010 playoffs, I went to a party where someone lamented having lost Halladay. Feeling smart that I actually knew the name of a current and good Blue Jay (how far we come, I guess), I said "well, at least we have Jose Bautista," vaguely aware that it wasn't quite the same—uh, I think one of them hits the ball and one of them pitches it? "I guess."
Roy Halladay retired yesterday. Even though I've only known him a few years, it feels exceedingly strange to say that. I just assumed we would have so many more chances to see him be Doc, even if he wasn't who he once was. He came back in July 2011, only a few months after I dove into baseball; Jose Bautista hit a home run off him, and I was listening intently on the radio, remembering that party and imagining them playing side by side. I never saw him pitch in person.
All this seems particularly poignant because Jarome Iginla is playing against the Calgary Flames tonight, and for all the hero I never had in Roy Halladay, I had it—have it—in Jarome. I never knew the Calgary Flames without him. He arrived when I was six years old and I don't remember that trade even a little—at the first game I went to, two years later, he was there. He was always there. For so many of us, there were no Flames without that creased-forehead smile and the hundreds and hundreds of goal celebrations, year after year after year.
Jarome meant everything to us. He was the beacon of hope that we still had a chance, that 2004 would end in joy instead of wrenching disappointment, that he could pull the team through its darkest days into a chance to hoist the Cup after fifteen, sixteen, seventeen years. And even though we could all feel it coming, letting him go was one of the most surreal moments of my sports life—seeing the press conference where they announced it for real, that first sad Flames game without him, and the afternoon when we turned on our TVs to see him in the Penguins blue thirds, skating with guys who weren't ours.
I don't have personal memories about Doc, but I imagine that if I did, they wouldn't be so different. He, too, was one of the best his team had ever seen. He brought fans together and gave them hope. And he felt such a connection to the team that he signed a one-day contract in order to retire a Blue Jay, an acknowledgment of the consuming emotional ties of sports. Roy Halladay retired without ever pitching in a World Series, foiled by the luck of baseball and a mortal body—sometimes life is just not magic enough.
I don't think it's reaching too far to say that in some ways I project Iginla onto Halladay, and a little vice versa—if I'd known Halladay in his Toronto years, or even his first as a Phillie, I'd have loved him with every part of myself, in that way you love sports heroes that transcends all other boundaries. Blue Jays fans still rooted for him after he left, and Calgary picked up where they'd left off with Jarome in Pittsburgh. Both deserve piles of championships, and I'm truly sorry we'll never see Halladay celebrate one on the mound. All I can do is hope that Jarome doesn't end up that way, too. I don't want to regret another thing I'll never see.
For tender day, a larger version of my #BlueJays holiday avvie.
(via taoofstieb)
Old Time Family Baseball: Names for the World Series Before It Was The World Series -
Last night marked the start of that annual classic, the World Series. It's that special time of year when two teams who really, really love each other come together and make a baseball baby.
But did you know it wasn't always known as the World Series? Here were the first names that were,…
And here we are for Game Three of the 2013 Butts 'n' Bunts showdown, ladies and gentlemen, and let me tell you, we've had plenty of both. *winks at camera*
The Blue Jays played their 162nd game of the season yesterday.
There won't be any more this year.
Good riddance.
Read More
[Baseball] breaks your heart. It is designed to break your heart. The game begins in the spring, when everything else begins again, and it blossoms in the summer, filling the afternoons and evenings, and then as soon as the chill rains come, it stops and leaves you to face the fall all alone. You count on it, rely on it to buffer the passage of time, to keep the memory of sunshine and high skies alive, and then just when the days are all twilight, when you need it most, it stops. — A. Bartlett Giamatti (via sfgiantsgirl19)
(via responsibleforthiswaterbottle)
And finally, September. See you in the spring.
162. Hey, hey, I guess it hasn't hit me yet … (at Rogers Centre)
You guys he's RIGHT THERE (at Rogers Centre)


text:
10.5: Start iChat without auto-login | 5 comments | Create New Account
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10.5: Start iChat without auto-login
speaking of holding shift, the same works for preventing auto login to user account. And as you are logging in — prevent start up items.
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This works in Adium as well.
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400 17th St.
Miami Beach, FL 33139
Category: Movie Theaters
Region: South Beach
Superman is a hero made for the big screen. And SoundScape's screen is one of the biggest around. This Wednesday, you can see the hotness that is Henry Cavill in Man of Steel, projected on a 7,000-square-foot projection wall. That rock-hard bod is bound to look even better when stretched across a building. In lieu of your standard hump-day happy hour, you can check out Clark and Lois and the skintight suit we all know so well. Pack a Publix picnic. Drink some Three-Buck Chuck. Snuggle up on a sheet. And save your pennies for last-minute Christmas shopping. Now that you can finally sit outdoors without your skin being seared like ahi tuna, it's the perfect time to make like a local and take advantage of one of the awesome perks of 305 life: watching movies outdoors for free in December. Take that, New Yorkers.
Wed., Dec. 11, 7 p.m., 2013


text:
LIONEL POSTWAR 6062 GONDOLA with METAL UNDERFRAME LN/OB
Sold For:
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Sold Date: 02/09/2011
Channel: Online Auction
Source: eBay
Category: Toys, Dolls, Games & Puzzles
LIONEL: RARE VARIATION OF THE 6062 GONDOLA WITH THE METAL UNDERFRAME IN LIKE NEW OR BETTER CONDITION IN IT'S VERY NICE ORIGINAL BOX! THIS VARIATION WAS CREATED BY LIONEL USING UP LEFT OVER 6562 BODIES ON THE FIRST PRODUCTION RUN OF THE 6062. ALL FOLLOWING PRODUCTION HAD NO METAL UNDERFRAME AS THE TRUCKS WERE RIVETED DIRECTLY THROUGH THE PLASTIC BODY. THE BOX IS ABOUT AS NICE A 6062 GONDOLA BOX AS YOU WILL FIND WITH THE PERFERATED PANEL AND PERFERATED THUMB PUNCH OUTS STILL PRESENT AND NO TAPE! THE PICTURES DO NOT DO THE ENDS OF THE BOX JUSTICE AS I HAD TO LIGHTEN THEM UP SO YOU COULD SEE THE DETAIL IN THE BLACK CAR. SHIPPING INSURANCE TO US ZIP CODES IS INCLUDED IN THE SHIPPING CALCULATION AND WE WILL COMBINE BOTH SHIPPING & INSURANCE CHARGES TO SAVE YOU MONEY ON MULTIPLE ITEM PURCHASES.We charge actual shipping only! We NEVER charge a handling fee! Please VISIT OUR EBAY STORE FOR GREAT LIONEL, KUSAN and PLASTICVILLE.(MT)
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OAKLAND, Md. (AP) -- A Maryland prison inmate is looking at more prison time after his conviction on charges of attempted first-degree murder, escape and carjacking in Garrett County.
A jury in Oakland convicted 38-year-old Larry Jerome Johnson Thursday. He could get a life sentence plus 70 years added to his prison term. No sentencing date was set.
Johnson left a highway work crew in September 2012 and used a pair of pliers to stab a correctional officer in the torso. He then got behind the wheel of a prison van, wrecked that vehicle, flagged down a motorist, stabbed him in the head and stole his car.
Maryland State Police caught Johnson after he hit a tree.
Johnson is serving a 20-year sentence for carjacking and handgun convictions in Prince George's County.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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The recent setbacks in psychiatric drug discovery involve failures to pin down receptors and pathways that provide targets for a magic bullet.
Experimental drugs that manipulate the neurokinin NK-3, neuronal nicotinic, and melatonergic receptors have not shown definitive efficacy in late-stage clinical trials in major depression and schizophrenia.
"It's remarkable how quickly things have unraveled," said P. Jeffrey Conn, Ph.D., in an interview with Psychiatric News. "There seems to be a dearth of new ideas that are viable."
Conn is a professor of pharmacology at Vanderbilt University and director of the Vanderbilt Center for Neuroscience Drug Discovery. Before 2003, he had led Merck's neuroscience drug development.
Conn co-wrote a review on opportunities and challenges in psychiatric drug discovery in the August 2008 Neuropsychopharmacology, which included a long list of novel receptors and corresponding drug candidates for treatment of major depression, anxiety disorders, and schizophrenia.
Four years later, many of these drugs have stalled or been dropped from development because of disappointing clinical trial results.
In the pharmaceutical industry, promising molecules are rushed into clinical testing because of the patent clock and long cycles of required clinical trials and regulatory filings. However, what often appears to work in rats may not lead to clear benefits when testing gets around to humans.
"Fifteen to 20 years ago, the research community was too naïve about drug targets," Conn said. Although the past two decades saw great strides in neuroscientific research, he explained, most of the notable recent failures of once-promising drugs had been in studies initiated for human testing 10 to 15 years ago, when the complexity of psychiatric disorders and their pathologies were not sufficiently appreciated.
Martin Sarter, Ph.D., a professor of psychology and neuroscience at the University of Michigan Department of Psychology, urges researchers to expand their view of drug targets.
"In past drug research, targets were too narrowly defined. A target was solely defined as a receptor or a molecular mechanism related to a disease," Sarter told Psychiatric News.
For example, receptor X is not properly expressed or is altered by mutation in patients with a certain disorder. Companies would take compounds that bind to the receptor, usually agonists or antagonists, and test them in animal models to see if any molecules would produce effects that suggest efficacy. The compounds that look promising in some models would then be put into human studies.
"This process is often more optimistic than is warranted," said Sarter.
The optimism might have been reasonable in the boom days of psychiatric drug development a few decades ago, when new antidepressants and atypical antipsychotics seemed to enter the market every year. Unfortunately, those drugs were derived from only a few neurotransmission systems without full understanding of their mechanisms of action. Now these drug classes have been exhausted, and breakthrough new drugs have not emerged.
Sarter shares Conn's opinion that there was a tendency in pharmaceutical development to throw new molecules into clinical trials without sufficient validation. He argued that to achieve predictable success, the drug discovery process must require an investment of time and resources in mapping neurological systems and psychobiology. In other words, we must understand how manipulating molecular targets can alter specific neurocircuits and what behaviors correspond to these neurocircuits.
"Our focus has primarily been on molecular targets," Sarter commented. "Between the molecular manipulation and a collection of behavioral effects is a black box. Research on what is in this black box has been largely ignored for a long time."
To achieve a rational approach to designing treatments, Sarter believes that targets should be redefined to include neurocircuits and clinical or behavioral deficits and their connections to brain chemistry.
It will be an expensive and time-consuming endeavor, he admitted, but without this research the cost of failures will mount ever higher.
A better understanding of the entire picture, from molecules to behaviors, can help researchers interpret failed studies. When a molecule fails to cause changes in behavior or mood, "we can peek into the black box and understand why it does not work and then devise ways to get around it," Sarter said. Otherwise, the risk of repeating failures is high.
Conn emphasized the importance of connecting clinical evidence with laboratory findings. In his opinion, animal models for neuropsychiatric disorders are not yet mature enough to reliably predict clinical effects.
The field of neuropharmacology has made substantial advances in recent years, Conn noted. Researchers can measure the binding profiles of a drug candidate in the brain, and "we now have solid knowledge about how to design drugs that can distribute to the intended places in the body, such as passing the blood-brain barrier," he said.
Alan Schatzberg, M.D., an APA past president and co-editor of the American Psychiatric Publishing Textbook of Psychopharmacology, Fourth Edition, agreed that the medical community today knows a great deal more about the neurochemical systems as well as specific circuits in the brain.
"It is time to use new approaches to developing agents that can target and affect these biological systems or circuits and then to look for clinical entities where such effects may be important," Schatzberg told Psychiatric News.
To achieve this goal, however, would require changes in how these clinical entities are viewed. For example, "if we had a drug for working memory or for stress-responsiveness reduction that cuts across diagnoses, how would we assess a drug for the FDA, which currently requires that drugs be assessed on the basis of discrete diagnoses?"
Schatzberg was one of the leading participants in the "Pipeline Summit" on new drug development for psychiatric disorders held earlier this year at APA headquarters (Psychiatric News, April 6).
"We're making tremendous progress, but I do think the cost and challenges are very great," Conn summed up. "If the community can sustain the necessary level of funding [to continue the research], we can be much more productive in the next 10 years."
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- Studio: Columbia Pictures
- Release Date: Apr 23, 2004
- Starring: Jennifer Garner, Judy Greer, Mark Ruffalo
- Summary: It is 1987 and Jenna is a 13-year-old girl on the brink of womanhood. The problem is that adulthood is just not arriving fast enough. She makes a wish on her birthday: If only she could be all grown up, she'd have the life she's always wanted. Miraculously, her wish comes true. (Columbia Pictures)… Expand
- Director: Gary Winick
- Genre(s): Fantasy, Comedy, Romance
- More Details and Credits »
Score distribution:
Positive: 20 out of 35
Mixed: 15 out of 35
Negative: 0 out of 35
The rare commercial comedy that leaves you entranced by what can happen only in the movies.
A charming, funny piece of wish-fulfillment for young girls -- and, if you're much older than that, a disturbing critique of modern male sexuality.
The possibilities of Jenna's confusion are exploited for full comic effect. Garner, who turns out to be a charming, abandoned comedian, makes Jenna's incredulousness and innocence very funny and occasionally even touching.
If there's a criticism to be made, it's that the script doesn't push itself far enough with the moments in which it excels.
You won't find a load of laughs in 13 Going on 30, but there's plenty of whimsy, which is a close cousin of genuine humor.
What could have been an engaging, maybe even enlightening story about the unfairly high price a woman pays for conducting herself like a man winds up as nothing more than a worthless, harmless and ultimately charmless piffle.
Score distribution:
Positive: 32 out of 39
Mixed: 3 out of 39
Negative: 4 out of 39
Sep 26, 2014One of the funniest comedy-dramas I have seen and this is easily Jennifer Garner's best movie.
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Oct 7, 2010I actually really thought this movie was cute! I've watched it a few times already..and I'll watch it again someday! I liked it! Jennifer Garner also played her role great! I love how she acted as a 13 year old in it, it's a good family movie. That will also give you a few laughs!… Expand
Feb 18, 2014This review contains spoilers, click expand to view. We all had at least one of those moments during our horridly awkward adolescent years where we wished we could just fast-forward to the part where things finally got good. In our fantasies we had survived puberty, landed our dream job and maybe, just maybe, had that someone special in our lives. It appears that so many of us have had these fantasies that film producers feed off of this notion by producing movies like 1988's "Big" or 2003's "Freaky Friday". Although it's based on a similar premise 13 Going On 30 depicts this fairly unoriginal concept in a refreshing and highly entertaining manner.
Jenna Rink, played by the ever-charming Jennifer Garner, is fed-up with living the cumbersome life of a teenager. Her only wish for her thirteenth birthday is to be "thirty, flirty and thriving". What she fails to realize is that the wishing dust her childhood best friend Matty gave her for her thirteenth-birthday will grant that very wish. Young Jenna is catapulted seventeen years into her future landing in the striking, business executive body of her thirty-year old self. Now that Jenna has the world at her fingertips she realizes she got everything she ever desired popularity, style and boobs. But why on earth is adult Matty no longer speaking to her? It turns out being an adult isn't all it's cracked up to be.
While Jenna struggles to navigate her way through adulthood to find a way to get back to her teen life director Gary Winick lends his expertise to the film's success. He has mastered the art of balancing the sincere scenes between Jenna and Matty with the witty light-hearted moments. One minute the pair will be reminiscing about their high school days when everything went sour and the next they're sharing Razzles on the swing set.
Granted, there are most definitely some cheesy moments but it wouldn't be a feel-good romantic comedy without them. What makes up for those cheese-worthy moments is the seamless acting of Jennifer Garner and Mark Ruffalo. Ruffalo fills the Converse shoes of adult Matty effortlessly. He's undaunted by the task of dancing along to "Thriller" with his equally as comical co-star Garner as they attempt to liven up a disastrous office party for Jenna's magazine company, despite his flushed cheeks hinting otherwise. I don't think Matty could have resisted Jenna even if she didn't have such a delightful giggle with the occasional, somehow charming, snort. Garner's charm continues to liven up the film as she replays the heart-pounding details of her kissing endeavor to a group of thirteen year old girls who are eager for mature Jenna's wisdom.
Unfortunately, being a thirteen year old in her thirty year old body Jenna doesn't exactly have a world of knowledge when it comes to boys; but she makes due with some noteworthy male experiences from her current trip to the future. However, she's slowly learning life lessons, bigger than how to tell if a guy actually likes you, that the rest of us can only hope to learn by the time we're actually thirty. This is where 13 Going on 30 fully earns a spot on my DVD shelf as a great movie for one of those nights where you have the urge to laugh and the need be entertained.… Expand
Aug 28, 2014Magic that can, unfortunately, only happen at the movies. Fortunate for 13 Going on 30, it hits all of the high notes. Jennifer Garner and Mark Ruffalo, in an early role, are perfect together.… Expand
matta.Sep 2, 2005I like Tom Hanks better. Stick to Alias girlfriend.
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