text:
Thursday, February 16, 2012
NASH on a ketogenic diet
NASH, it all comes down to this paper (thanks Liz).
Does sustained ketosis produce NASH? Well yes, or at least something like it. Just look at the picture:
The dark staining patch is made up of neutrophils. You don't want clumps of them aggregating in your liver.
That's what you get if you feed F3666 to C57BL/6 mice. It is, undoubtedly, intensely ketogenic. But is it anything else?
"These are typical amounts of nutrients calculated from
available information. Actual assay results may vary.
For more information contact Jaime Lecker, Ph.D."
The paper (and the F3666 pdf) specifies 16% of PUFA in the fat, which seems rather low considering that USA produced lard (the main ingredient) appears to have 32% PUFA (almost all omega 6) but, even at only 16%, these PUFA are 16% of 95% of your total calories. That's an awful lot of PUFA...
Do PUFA matter for the development of NASH? Probably. From this N and M paper:
"The lipid composition of the different diets which induce steatohepatitis (see Table 4) [19,20,51,52,54], were lard and corn oil, both oils rich in unsaturated fatty acids. We can observe that fat of all the diets inducing steatosis and inflammation (Table 4) were richer in MUFA and PUFA (>30% and >20% of total fat respectively) as compared to our diet (5% and 2%). The injurious effect of unsaturated fatty acids, and particularly n-6 polyunsaturated fatty acids, was associated with enhanced lipid peroxidation and decreased concentrations of antioxidant enzymes, implicating oxidative stress as a causal factor. Indeed, different studies showed the pro-inflammatory effect of polyunsaturated n-6 fatty acids which exacerbate liver oxidative stress [60,61] and promote the development of NASH."
So there is a message: If you are going to eat a very high fat diet in the long term, you should pay serious attention to PUFA creep. Having cirrhosis is not likely to help you make old bones in good shape. Perhaps go easy on the commercial mayonnaise and just spread some butter on your cheese... Actually I tend to add butter to my beef if it's too lean (only happens when eating out, no way we would choose lean beef to cook at home!)...
It makes me wonder about saturophobes who might be swilling PUFA to lower their LDL and triglycerides, with or without a LC diet... More potential victims of the cholesterol hypothesis I suppose.
56 comments:
- JimPurdy.blogspot.com said...
I just bought a bunch of packages of "Wholly Guacamole," which lists the ingredients as Hass Avocados, Jalapeno Puree (white vinegar, jalapeno peppers, salt) Dehydrated Onion, Salt, Granulated Garlic.
Avocados are very high in fat. Should I be concerned?
- 6:55 am
- ItsTheWooo said...
Bah who eats mayo? That's only useful for smearing on bread to choke down dry meat. Neither of these apply to a ketogenic diet where the meat is fatty and bread is not eaten. Mayo serves no purpose. :D
My take:
1) I doubt this is true at all in humans
2) who eats a 95% fat diet? NOBUDDIE except a poor lab animal. Poor lab animal :(
In humans eating people food promoting of ketosis, like fatty meat and dairy and avocados and macadamia nuts and cream, I sorta doubt this effect would occur.
@Jim Avocados are one of the healthiest things ever. I eat like an avocado every other day. They are mostly mosaturated fat. Fitday states they are 53% monosaturated, 10% pufa, and 12% saturated (75% fat total). The main problem appears to be inflammation from omega 6.
Unless you are planning on drinking a weird lipid emulsion from a straw and eating severely deficient protein and no carbohydrate at all, it is safe to throw this study in the waste bin of importance to humans following theraputic mildly or moderately ketogenic low carb diets. Even 10% pufa of an avocado is a whole lot less if fat is only 65% of total calories (vs 16% of 95% of calories which is a ton more).
- 7:38 am
- blogblog said...
When I see the word "mouse" I know to read no further.
Mice can't tolerate a diet containing more than 6-8% fat. Feeding a ketogenic diet to a mouse is sheer lunacy.
- 11:29 am
- blogblog said...
@Woo said:
"Jim Avocados are one of the healthiest things ever."
I couldn't disagree more. Avocados are little more than toxic waste. They contain (amongst other toxins) high levels of the potent fungicide persin which is toxic to virtually all birds and mammals. Persin is highly toxic to breast tissues and the myocardium and is used to treat certain breast cancers.
Unfortunately health authorities have no interest in regulating existing foods.
- 12:03 pm
- LeonRover said...
"ASH on an old man's sleeve
Is all the ASH the burnt roses leave.
Dust in the air suspended
Marks the place where a story ended."
I believe similar happens with NASH.
Jim Purdy & blogblog
Re Avocado or persin
Paracelsus: The dose maketh the poison.
- 12:17 pm
- pablo DLS said...
pino way we would choose lean beef to cook at home...
thats great and all - but what if all the meat available to u is 100% CAFO meat?... how do you suggest i should limit dat pufa overland intake specially eating a 60& fat diet?.. basically im eating this abomination
( observe the end)
so now im going for the absolutely LEANEST driest cuts possible + a shitload of butter
( not good for that 450 cholesterol )
your ideas? ( btw i dont know what to think about dat insulin theory... i ditched the lower prot idea @ ratios and im eating crazy amounts of prot a day ... and im leaner that evar? (65kgr) ex 180gr raw homemade cottage cheese , milk, sucrose, + the usual 140gr pastured yolks + lots of butter a day.
- 3:16 pm
- pablo DLS said...
btw, 2:30 for the good stuff...
( video)
- 3:22 pm
- john said...
So with 95% fat, I'm going to guess "fatty liver" is unavoidable, as these animals are probably quite insulin resistant everywhere. With considerable PUFA, these mice have markers of excess "oxidative stress" and inflammation; this probably doesn't happen with butter?
With about 15% protein, as in the Mavropoulos prostate cancer papers, mice have low fatty liver [compared to Western and low fat/high sucrose] despite considerable PUFA. I wonder how these mice's inflammation/stress compares to the 5% protein+high PUFA mice and the [theoretical] 5% protein+low PUFA mice.
- 4:15 pm
- Moose said...
@ John, from the mouse paper:
"but surprisingly insulin-induced hepatic Akt phosphorylation and whole-body insulin responsiveness are not impaired."
Insulin-sensitive glucose intolerance...
But perhaps they just don't have enough glycogen/gluconeogenesis to recover from the insulin tolerance test... a false negative of sorts.
- 4:41 pm
- Nigel Kinbrum said...
I wonder how much choline there is in a diet consisting of 95% fat? Not a lot, I suspect.
@blogblog: Eat organic avocados.
@Jim: Don't worry, be happy.
- 6:00 pm
- LeonRover said...
Hey Petro
I'm guessing these guys are similar to the guys in your FIRKO-ise post.
The abstract refers to "distinctive nutrient milieu" and "unique signatures".
Are these similar to the "unique metabolic state" of FIRKO-ised?
(not prepared to pay for this one!!)
- 6:05 pm
- CharlesVegas said...
- This comment has been removed by the author.
- 11:18 pm
- CharlesVegas said...
I would appreciate your comments on this paper
A 20 percentage point decrease in dietary fat (60%->40%), but higher sat fat, was apparently enough to wipe out the livers of these mice.
- 11:19 pm
- CharlesVegas said...
Also, if I may, in the Garbow paper the ketogenic-diet mice had "systemic glucose intolerance" yet had unimpaired "whole-body insulin responsiveness".
Is that a contradiction?
- 11:33 pm
- James said...
From your analysis of the Nash paper it's evident that high n-6 content was a likely candidate for the steatosis observed in the rats' livers. The Nutrition & Metabolism paper showed that rats fed high sat-fat (42 to 45% of calories) do not develop steatosis, but this does not regute the possibility that a 95% calories as fat diet may not be hard on the liver.
The reason i'm wondering about this is because i've been thinking lately about physical activity while on the KD. When you up the energy demands of your muscles, while they can only get energy from fat, is your liver going to be able to meet this demand? I'm not an expert on this topic but i guess what i'm wondering is if the liver would feel strained in producing such high levels of ketones long term.
- 1:36 pm
- James said...
Sorry in my previous post i meant to say "this does not refute the possibility that a 95% calories as fat diet MAY BE hard on the liver".
- 1:42 pm
- Tony Mach said...
With regards to n-6 PUFA excess I will through in one name: Bill Lands. (Just in case you haven't run across him yet)
His presentations may be awful, but he has a lot of material gathered on the health effect of the screwed up n-6/n-3 ratio. His singular focus on this may be a bit wrong, but I would suspect the studies he cites from are a treasure-cove on n-6/n-3.
- 3:05 pm
- Nigel Kinbrum said...
See The Sweet Truth About Liver and Egg Yolks -- Choline Matters More to Fatty Liver Than Sugar, Alcohol, or Fat
- 8:24 pm
- ItsTheWooo said...
Interesting; I wonder if perhaps this substance is relatively non-toxic to humans? From what the internetz tells me, it seems quite toxic to animals, targets breast tissue leading to noninfectious mastitis in animals... but given the numbers of people eating avocados regularly I would assume we would hear at least some case reports of a toxic reaction.
Cancer cells are not like noncancerous ones so perhaps the substance only is toxic to these particular breast cancer cells. It appears to work through an estrogen receptor mechanism and there are some kinds of breast cancers which obviously are fueled by estrogen.
It seems to be the case most any plant food will have substances that can be toxic to animals or humans, stands to reason this is the case; mast plants have no other defense besides chemicals.
- 1:24 am
- Unknown said...
Does that mean Fish oil is bad on a high fat diet ?
- 9:32 am
- Jimmy said...
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- 12:35 pm
- Jimmy said...
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- 12:59 pm
- vlprince said...
Interesting... I wonder how much of this is a liver-centric phenomenon and how much it is an issue that starts in the gut. Recent research exploring alcoholic liver disease suggests that the type of fat in the diet causes hepatic pathology by altering intestinal permeability. http://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2011.01673.x/full
It's interesting to have a suggested mechanism, as it's long been noted that saturated fat protects against ALD (http://www.ncbi.nlm.nih.gov/pubmed/2646971) but without a clear mechanism (there has been some talk of an increase in adiponectin being protective).
So perhaps the hypothesis should be that an increase in PUFA (especially linoleic) causes an increases in gut permeability, leading to increased blood LPS and other substances that lead to inflammation and an inflammatory process in the liver. Of course, an overload of PUFA in the liver, with or without increased inflammation cause by gut permeability, is likely to cause inflammatory issues on it's own.
I wonder what role CYP2E1 plays in this pathology. The expression of CYP2E1 is induced by a high fat diet (as well as fasting, alcohol, and other processes) and CYP2E1 is involved in lipid peroxidation. Knocking out CYP2E1 attenuates alcoholic fatty liver (probably others too, I'm just aware of the ALD research). I'd think that a high fat/high PUFA diet which simultaneously induces CYP2E1 and gives it a heap of substrate (in the form of PUFA) to peroxidate would be a rather bad idea.
- 3:01 pm
- M said...
Hi, Peter. I wonder if you, or one of your readers, could answer this question. I'm having trouble keeping away from sugar. I try to stick to an OD diet, but every night I get cravings. No matter how tired I am, I find it very difficult to go to sleep unless I have something sugary. It is something of an addiction, isn't it? Is there some way of getting over it, or is it purely a matter of power of will, that is, forcing myself to not eat it, period? Thanks.
- 3:07 pm
- nancan said...
@M: Sugar is addictive for some of us, and you have to get it out of your diet or you will always have cravings. It only takes a few days for sugar to get out of your body, but it took me about a month before I finally changed my habits sufficiently to quit craving sugar. I substituted a nut butter treat made with equal parts Kerrygold butter, coconut butter/or oil, almond butter, with a handful of raw walnuts tossed in: pour in small container, score, refrigerate (or cool larder). A small square was just right to replace the junk.
Cf: www.sugaraholics.com
- 3:45 pm
- nancan said...
New study on diabetes which may be developed in gut:
- 3:47 pm
- ItsTheWooo said...
@M Have you ruled out blood sugar instability? Take your blood sugar throughout the day, and take it at night when you get the cravings. If you are noticing that your blood sugar is changing a lot (e.g. it is 95 at all times but when the sugar cravings come you are 75) then the sugar cravings may be caused by hypoglycemic phenomenon.
Of course if your blood sugar is absolutely hypoglycemic at the time (<70) this would be an obvious cause of sugar cravings, however I specifically advice to monitor your sugar at various points in the day because absolute hypoglycemia is not as important as the steepness of the decline and where your relative baseline blood glucose is. The body produces reactions to hypoglycemia when sugar drops too quickly, too suddenly, or if the sugar is below the natural glucostat particularly if it occurs quickly.
Assuming you are sure it is not hypoglycemia, many people find low carb has a stimulating effect and sleep becomes difficult. You may be craving sugar to help calm nad relax you in which case I would advice to use other methods, like sleepytime tea, melatonin/5-htp so on. There are a lot of ways of suppressing the stress response without resorting to eating sugar.
- 5:02 pm
- CharlesVegas said...
@nancan: This paper has a similar theme:
The gut microbiota as an environmental factor that
regulates fat storage
- 6:08 pm
- George Henderson said...
In the World Book of Meat Dishes by Nina Froud, 1965, my best low-carb cookbook, any dish that calls for lean meat is prepared with butter or olive oil. If fat is cut off, then fat is supplemented.
Nina Froud's Beef Stroganoff
750g fillet of beef (note: blade steak or rump is fine)
1 tsp salt
1/2 tsp pepper
2 medium-sized onions
125g butter
125g or 1&3/4 cups sliced mushrooms (optional, I prefer it without
these actually)
1 tbs tomato puree
1 tsp made mustard (English)
1 cup stock (or a tsp of fish sauce in a cup of water is fine)
1/2 pottle sour cream (original, not lite)
1 tbsp chopped parsley
Wash meat, trim away gristle, and 2 hours before cooking cut into
"straws" 1/4 inch thick by 1 inch long. Sprinkle with S & P and leave
to sit (or stand).
Slice the onions and fry in butter
Add mushrooms and fry together for 2-3 mins.
Add meat and fry together for 7-9 mins, stirring with a wooden fork.
Add tomato puree and mustard, dilute with stock, bring to boil.
Add sour cream, cover with lid, simmer for 15 minutes (30 mins if
using a cheaper beef cut)
Bring to the boil, sprinkle with chopped parsley.
(I leave out 1 tbsp flour, it doesn't need the aggravation)
- 11:20 pm
- George Henderson said...
Chromium piccolinate is the cure for sugar cravings. Marvellous stuff, just use a short course to get over the habit, repeat if necessary.
My (partial) hypothesis is that PUFAs in liver slow down beta-oxidation of MUFA by competing for saturase enzymes, causing both to accumulate. You do see the ratio of MUFA to SFA increase in these conditions.
- 11:27 pm
- M said...
Thanks for the replies!
- 2:34 pm
- Robert Andrew Brown said...
Tony Mach said
"With regards to n-6 PUFA excess I will through in one name: Bill Lands. (Just in case you haven't run across him yet)
His presentations may be awful, but he has a lot of material gathered on the health effect of the screwed up n-6/n-3 ratio. His singular focus on this may be a bit wrong, but I would suspect the studies he cites from are a treasure-cove on n-6/n-3."
Bill Lands is a genius before his time.
The Omega 3:6 imbalance is not the only health issue, but is way more important than most people realise.
Thanks Peter for another fascinating find and thought provoking commentary - great work (-:
- 12:09 am
- CharlesVegas said...
Yet this AHA Science Advisory reads like a frigging testimonial for corn oil. I am utterly confused.
- 6:33 am
- nancan said...
@George Henderson: What do you mean by a "short course" of chromium piccolinate? I've been taking as a supplement for years, and no doubt it helps with sugar-starch cravings, but to date nothing has stopped them totally, except a ketogenic diet.
- 3:11 pm
- George Henderson said...
@ Nancan, yes, but has M tried it?
I would suggest that if you were able to follow a ketogenic diet (which is of course the Gold Standard for all cravings) to begin with then sugar and carb cravings were not insurmountable.
Chromium at around 400mcg per day as piccolinate makes carbs manageable enough to restrict easily. Some people might need more, and co-factors like biotin and magnesium might also be needed.
The point is merely that chromnium is one of the more effective supplements for its intended use. If you didn't need it, you wouldn't notice.
- 9:47 pm
- CharlesVegas said...
Since I brought it up, I found an editorial commentary and a review paper by Ramsden that challenges the AHA Science Advisory:
British J Nutrition Vol 104 Issue 11 (not paywalled)
- 1:22 am
- donny said...
Someone posted this on Active Low Carbers, yoinked from another forum.
Sucrose Counteracts the Anti-Inflammatory Effect of Fish Oil in Adipose Tissue and Increases Obesity Development in Mice
They have some numbers on liver triglycerides. Corn oil+sugar=fatty liver. Corn oil+protein doesn't seem to have this effect. A number of amino acids-glutamine, glycine, taurine, methionine, I'm sure the list goes on, have been shown to be important to fat metabolism, in the liver and elsewhere. Low methionine by itself can cause fatty liver. Omega 6's in large amounts suck, but we'd really better not be protein deficient at the same time.
Charles Vegas, that first study you posted, I can't see the full title. Probably my stupid browser's fault. Would you mind posting the study's title, so I can google it? Thanks.
- 10:51 pm
- CharlesVegas said...
- This comment has been removed by the author.
- 11:45 pm
- CharlesVegas said...
@donny: The first paper I posted is
Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
This link should work:
AJP - GI Nov 2011 vol 301 no. 5
Full article is paywalled.
- 11:47 pm
- pablo DLS said...
lol Thanks!, regarding sucrose, just eat it first think in the morning. is mostly harmless, that is, if you are not a saggy bag of fat and bones!
- 7:26 pm
- Boomka Music said...
"Omega 6's in large amounts suck, but we'd really better not be protein deficient at the same time."
"Don't be a typical vegetarian", you mean?
- 8:51 pm
- Robert Andrew Brown said...
- This comment has been removed by the author.
- 7:10 pm
- Robert Andrew Brown said...
Many thanks Charles Vegas for the useful links.
Thanks Donny - that is a really thought provoking paper. Thoughts arising . . .
Protein does not greatly increase fat deposition, due to metabolic costs / effects.
Improving the Omega 3:6 balance effects liver metabolism fat composition and content.
On the basis of the Omega ratio selected, Omega 3 had limited effect on the overall storage of fats, but increased omega 3 and decreased adipoycte omega 6 content.
The conclusions as to the effects of Omega 3 and 6 need to be pondered in light of a base diet that contained 70g per kg of soybean oil. Soybean as well as being high in Omega 6 contains some Omega 3. It would have been interesting to have had a group fed a very low Omega 3:6 as a base point, for a number of reasons including the saturation of tissue membrane at about 4% intake, and the very low levels, likely under 1%, needed to maintain essential health. Was Omega 6 intake already above its most sensitive range ?
I also look forward to reading the Ramsden paper, which looks even more fascinating.
Thanks again - highly thought provoking
- 7:13 pm
- George Henderson said...
I'll put the "substrate hypothesis" for omega 6 into clear terms. It is supplementary to insulin-signalling, LPS activation and other scenarios, but functions at a more basic metabolic level.
Long-chain, polyunsaturated fatty acids, when present as a significant % of calories, are ipso facto a calorie source, that is they must be catabolised via beta-oxidation to yield ATP.
They may even be prioritised as substrates over MUFA and SFA because this would tend to protect the cell from peroxidation and other consquences of high PUFA.
PUFA may compete for, or inhibit, enzymes (enoyl-CoA-isomerase and 2,4,dienoyl-CoA saturase) also needed for the saturation and of MUFA (this may also be part of trans-fat toxicity as metabolising trans fats would presumably require the same enzymes).
Different rates of PUFA clearance due to different genetic expression of these enzymes or availability of micronutrients required for PUFA clearance might account for variations in human responses to PUFA, for example PUFA from a nut or fish diet might be cleared faster than pure oil because of appropriate micronutrients for PUFA processing (including selenium and tocopherol) being present in the foods.
- 9:05 pm
- George Henderson said...
Here are some papers which either contradict or support the substrate hypothesis, and certainly complicate it enough for a make-over.
They show different ratios of MUFA/SFA related to steatosis - mostly less MUFA - and the mechanism is reduced desaturase activity. There are also variations in PUFA.
In this paper (steatosis in chonic hep C) there is more MUFA and PUFA, less SFA associated with steatosis.
In this mouse model (high-fat feed and Carbon tetrachloride), less MUFA and more SFA (due to less activity of stearoyl-CoA desaturase-1 (SCD1))
This is a very interesting review of the literature:
Though I suspect that their conclusions are not justified by the data, they have pulled together a lot of interesting papers.
Animal studies have pointed out that, after intestinal absorption, monounsaturated fatty acids (MUFA) and PUFA produced a higher thermogenic effect (16) and higher oxygen consumption (17) when compared to SFA. However, when PUFA were added to a high-MUFA diet (high PUFA/SFA ratio) for 8 weeks, the expression and activity of hormone-sensitive lipase (HSL) was up-regulated and adipose tissue peroxisome proliferator-activated gamma (PPARγ) was reduced when compared to a high-MUFA diet, which significantly elevated de novo hepatic lipogenesis (18).
- 10:49 pm
- George Henderson said...
Carbon tetrachloride mouse model:
- 10:51 pm
- Suporna Sarkar said...
Nice Blog !
I Like This Very Much.
Methods of Modern Farming
Poultry Nutrition
- 5:22 pm
- George Henderson said...
Unknown writes "Does that mean Fish oil is bad on a high fat diet ?"
I'm coming round to the view that a higher intake of animal omega 3s such as EPA and DHA may be desirable on a ketogenic diet.
This is based on the thyroid-enhancing effect of these lipids, which may be the answer to the "euthyroid sick syndrome" panic, which is fuelling the current "safe starch" craze among low-carbers.
If VLCKD decreases thyroid activity, fish oil n-3s enhance it in many tissues such as liver; if VLCKD (in this scenario) can elevate LDL, fish oil n-3s lower it.
Note that in the example below, soy bean oil, a purported "source" of omega 3, was used as the placebo control substance.
Thyroid hormone contributes to the hypolipidemic effect of polyunsaturated fatty acids from fish oil: in vivo evidence for cross talking mechanisms
n-3 polyunsaturated fatty acids (n-3 PUFA) from fish oil (FO) exert important lipid-lowering effects, an effect also ascribed to thyroid hormones (TH) and TH receptor β1 (TRβ1)-specific agonists. n-3 PUFA effects are mediated by nuclear receptors, such as peroxisome proliferator-activated receptors (PPAR) and others. In this study, we investigated a role for TH signaling in n-3 PUFA effects. Euthyroid and hypothyroid adult rats (methimazole-treated for 5 weeks) received FO or soybean oil (control) by oral administration for 3 weeks. In euthyroid rats, FO treatment reduced serum triglycerides and cholesterol, diminished body fat, and increased protein content of the animals. In addition, FO-treated rats exhibited higher liver expression of TRβ1 and mitochondrial α-glycerophosphate dehydrogenase (mGPD), at protein and mRNA levels, but no alteration of glutathione S-transferase or type 1 deiodinase. In hypothyroid condition, FO induced reduction in serum cholesterol and increase in body protein content, but lost the ability to reduce triglycerides and body fat, and to induce TRβ1 and mGDP expression. FO did not change PPARα liver abundance regardless of thyroid state; however, hypothyroidism led to a marked increase in PPARα liver content but did not alter TRβ1 or TRα expression. The data suggest that part of the effect of n-3 PUFA from FO on lipid metabolism is dependent on TH signaling in specific steps and together with the marked upregulation of PPARα in liver of hypothyroid rats suggest important in vivo consequences of the cross-talking between those fatty acids and TH pathways in liver metabolism.
- 8:26 pm
- Renaud said...
Thanks for your blog Peter, i realy like it.
Some comment about this abstract ?
- 4:49 pm
- szielsdorf said...
Bottom line, what is the correct ratio of fats to eat in NASH liver disease?
- 1:33 am
- Peter said...
Bottom line: Butter but with restricted carbohydrate.
Renaud: Missed this one, if you have marked to be updated I would comment that PUFA intake during pathological insulin resistance improves matters temporarily by increasing insulin sensitivity in adipocytes, hence the muscles, so will lower insulin levels, at the cost of increasing adipose depots (or hunger if calories are limited). Many of the ideas based around F:N ratio of PUFA indicate a failure to develop the insulin resistance appropriate for a given level of fat in the diet. The effect on the liver in the longer term is cirrhosis, ie the pathological response to caloric overload of hepatocytes with calories to which they fail to say no to. Excess electron transport in the absence of demand = pathological free radicals. I'd need the full text to see how they loaded the deck in this particular study to not find this...
- 8:36 pm
- George Henderson said...
Very interesting; this might help to solve the mystery of the metabolic push-me-pull-you, the diabetic hepatocytes that emit both glucose and triglycerides simultaneously
That krill oil at low doses, but not fish oil, can dampen both outputs is also interesting:
- 8:50 pm
- Renaud said...
Thanks Peter. Interesting, as allways.
I'm nearly certain that a high fat diet is better with low PUFAs. That's what i've done for a while. But i'm trying a higher carbs diet, and maybe in this context PUFA are more welcome, relative to SAFA... as long as total PUFA calories stay relatively low.
- 9:53 pm
- Peter said...
George, when we get back to cirrhosis I have some ideas about iron overload that may need some kicking around. Or kicking out. The line of thinking goes along as: PUFA + carbs w/o insulin resistance = hepatocyte caloric overload = enough free radicals to trigger necrosis, let alone apoptosis. How do you avoid this? Maybe some heavy metals to generate free radicals enough to provide an emergency supply of superoxide w/o going over the top. Cirrhosis is the end result of this elastoplast on corn oil toxicity, or possibily the result of this elastoplast failing. Low dose fish oil seems fine, 40% of calories as fish oil is catastrophic...
Renaud, just be careful. LC is a starvation mimic. It's physiological. There is nothing physiological about using PUFA as a metabolic tool. They might help some aspects and yet trash others. The Law of Unintended Consequences is a harsh mistress!
I tend to leave the increase in carb intake to people who think the increase in mitochondrial numbers produced by palmitate during LC has cured them, and they can stay cured using exercise as a substitute for palmitate free radicals. Let's look at them 10 years down the road before deciding it's OK to mainline glucose.
- 9:18 pm
- George Henderson said...
I'm thinking, insulin sensitivity at the cell surface caused by excess PUFA meets insulin resistance in the nucleus caused by ROS>Fox01, resulting in an overfed hepatocyte that has to export both lipids and glucose...
- 9:22 pm
- Peter said...
Hmmm, I'm still thinking about PUFA failing to generate superoxide as a problem at the mitochondrial level, certainly if provided in bulk... We'll see how things pan out. I haven't really started to pick at it closely. It may turn out to be in the same line as the brain generating canabinoids from AA as signalling molecules but the basis appears to be that the parent molecule, LA, is intrinsically fat storing at the adipocyte mitochondrial level and it's derivative fine tunes this through the brain. Lots to think about. Both ideas may be wrong!
- 3:47 am


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For the last five seasons, Daniel Paille has been a member of the Boston Bruins. Since he came over in a trade with the Buffalo Sabres, the thirty year old winger had brought impressive speed and remarkable durability in his role as part of the Merlot Line. Throughout the season, Paille was promoted up to the third line to provide additional speed and assistance to the Bruins special teams.
Daniel Paille, like his fellow Merlot Man Gregory Campbell had a decent season. He put up eighteen points (nine goals) for the Black and Gold, making this season his second best overall performance as a member of the Bruins. If you factor in the games he was out due to concussions and injuries, it's probably his best year as a Bruin. He led the fourth line with a plus/minus of +9. His speed and skill on special teams helped him big a solid factor in the Bruins penalty kill. "Paille with a breakaway!" became a common sentence uttered by local media due to his ability to kick in the afterburners when needed.
While many people acknowledge Paille's speed as his greatest asset, I have to disagree with them. In my opinion, Paille's best skill is his ability to play a clean hockey game. He always plays on an even keel, and compared to his fellow Merlot Men (Campbell and pugilist extraordinaire Shawn Thornton) he's positively serene. Paille accrued only six minutes in penalties the entire season. Many of his teammates blew past that total in a single game.
Daniel Paille should have no trouble staying with the Boston Bruins. The former first round draft pick will likely see himself moving up a line when the likely disbandment of the Merlot Men occurs at the beginning of next season. Paille's speed and solid game play should find him on the third line playing wing for the new "How Swede It Is" line, centered by Carl Soderberg. His cap hit is marginal, and he has (in my opinion) exceeded expectations of what his role was to be these last couple of seasons.
Tags: Boston Bruins Daniel Paille


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Wear It Now
GQ Shops: The Best Stuff at Urban Outfitters
A hipster emporium no more, Urban Outfitters has stepped up its menswear game. Time to get on board
One of the reasons we love Urban Outfitters is their ability to tap into cult brands and bring them stateside, like Wood Wood from Denmark. This hooded nylon jacket is perfect for spring weather and the cool color blocking also serves to hide the piece's pockets.
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- Spring 2012
- Matthew McConaughey: America's Space Cowboy
- Logan Lerman Went to Bootcamp with Brad Pitt for Fury
- Under the Influence: How Def Jam's Early Days Inspired this Season's Look
- Outlaw, Artist, Wild Man, Style Icon: How Dennis Hopper Inspired this Season's Look
- Can You Guess the Leading Man in These Nicholas Sparks Movie Posters?
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- Chart: The Family Tree of Bourbon Whiskey
- Recipe: Semi-Summer Salad - Chef Jeff Taibe of Oak + Almond
- The Great Franco-Italian Pasta Experiment
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Here's my obligatory top ten films list for 2008…
1. The Dark Knight
The greatest superhero movie of all time hands down. Heath Ledger will never ever be forgotten thanks to his unforgettable turn as the Crown Prince of Crime. I watched this after doing The Godfather and The Godfather II back to back a few days ago, and it didn't get blown off the screen. Not at all, actually. It's a better crime sage than Heat and a better comic book flick than either Spider-Man or Superman all in one film, with some of the greatest action sequences ever to grace the silver screen. It's already one of my all-time favorite films and it only keeps on getting better.
2. The Wrestler
More Hoop Dreams than Rocky if you ask me — this baby felt real. The only performance that might be better than Ledger's TDK one is Mickey Rourke's portrayal of Randy "The Ram" Robinson. Un-fucking-believable. I'll have a full review out on this one soon.
3. Wall-E
One of my favorite animated and sci-film films…ever. For more from me on Wall-E go here.
4. Slumdog Millionaire
When Danny Boyle can make films like Trainspotting and this and everything else in between…wow, that's Scottie Pippen versatility. If you don't like this film, you have issues. It was like I was watching an even better version of City of God.
5. Wanted
I love, love, love this flick. Watch this shit all the time. Other than The Dark Knight, this was easily the most rewatchable blockbuster of the year.
6. The Curious Case of Benjamin Button
This decade's Forrest Gump, which makes sense since it was written by the same scribe.
7. Forgetting Sarah Marshall/Role Models (tie)
Two ultra-original comedies that pulled off "feel good" as well as they did raunchy. Hopefully, this is a trend. I liked both of these better than Tropic Thunder, but that's just me.
8. Doubt
The only way this could have been better is if John Patrick Shanley had of directed the same cast onstage.
9. Iron Man
If not for The Dark Knight, this would have been the summer's best comic book flick. A lot of fun, and I think that Downey and the rest of the franchise have brighter days ahead of them.
10. Tropic Thunder
On the rewatchability scale, it would rank even higher. Again, not quite as funny as the other two comedies on this list, but pretty damn close. Robert Downey Jr. carries what would otherwise be a pretty average film. Supporting turns from the Crusiter, Danny McBride and Nick Nolte don't hurt either.
Now, I still haven't seen a lot of films. Religulous will definitely be among my faves when I see it. I think Frost/Nixon, Gran Torino, Let the Right One In, Milk, Vicky Cristina Barcelona and The Visitor have a chance as well. Definitely check all these films out, especially if you're a film buff like me!


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My name is Eric. I live with severe depression, it has been with me my whole life. The genetics have been with me but it wasn't easy the way I grew up especially with my grade school. I was constantly being bullied and beaten up severely for my weight, intelligence (Traumatic Brain Injury as an infant) and any weird quirk I had during that time. That's where I learned to repress my depression and shut down in hard times. I also was abused as a child as well, which didn't help either. There were times it hurt repressing old feelings: I unintentionally shut people out and scared people with suicidal attempts. But I learned to how to cope with different techniques and with the right help. I'm looking to work with children as a teacher with my two years in human services. I also am helping others on my Facebook Mental Illness Awareness Page.
Hello! I am sorry that was your experience. I did not really know about Depression until in my 30-ish when I had a...


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Rated 3.8 out of 5 by 120 reviewers.
Rated 4 out of 5 by DaveInCT Solid, not spectacular I stay here 10-12 times a year on business, so most of the front desk, concierge and parking staff recognize me, and are always friendly, helpful and efficient. Concierge will drive you to restaurants in town, and pick you up when you call after dinner. This is a big bonus, although if it's a nice night, and you don't mind walking, it just a 15 minute walk to Old Town. I usually call down to the valet a few minutes before heading down from my room in the morning, and when I do, my car is always waiting for me when I get downstairs. There is nothing more annoying to me than calling down and still having to wait for my car, and that NEVER happens here. Tip those valets, people! *wood recognition is OK, I get my points amenity, and occasionally an actually upgraded room as opposed to just the free bottled water in a regular room. The last time I came with family, the front desk worked to get me an upgrade to a larger room so we'd have ample space, and I greatly appreciate that. Sure, it's nice to get upgraded to a suite, but when I'm travelling alone, it's not really important, a single room will do. But when I've got the kids with me, it's important, and they took care of me when I needed it. The major weakness in this hotel is back of house service. Room service is very slow. Housekeeping, too, when you call down for something, though they do a good job of cleaning while I'm gone (if I don't decline housekeeping for the 500 point "green" bonus). The restaurant is not worth mentioning. Standard boring never-changing Westin "superfoods" menu, there is really no reason to eat here with all the other dining choices in town. The lobby lounge/bar is usually relaxed and quiet, spacious and comfortable. Overpriced drinks, of course, but par for the course. Good place for a nightcap with an expense account. Rooms are beginning to show hints of age, and the hotel is probably going to start looking like it needs a refresh in a couple of years, but as of right now, they are perfectly acceptable. Outdoor pool is nice, but not huge. Same problem as with room service when ordering food by the pool -- it takes forever. Gym is just fine, machines are mostly very new. Pretty decent WiFi connectivity for a hotel. Ask for the platinum access code at the front desk. Overall, a solid choice in Pasadena, and I'll be returning (again and again). January 9, 2012
Rated 4 out of 5 by Csaavedra Things need improvement I love this place for the people and the care they give me BUT! In the past 2 years the cleanliness of the hotel has left me wanting to bring my own towels and sheets. On several I have gotten dirty towels and sheets. Questionable stains on the desk and chairs have made me feel less and less comfort. December 11, 2011
Rated 5 out of 5 by RAH1149 Very Comfortable & Convenient Very nice, we enjoyed our stay. We were there for a wedding and the location was very convenient. My only criticism is that $12.00 per day for internet access is ridiculous. September 24, 2014
Rated 2 out of 5 by Manju Guest Services For this to be a 4 star classy hotel I was so disappointed with the lack of customer appreciation or guest services. I had a room for 2 nights. They made me check out on the first day and recheck back in the next day. It was horrible. When the staff checked me out, my room was bumped because they had overbooked rooms and they had to find me another room. I had to move! I was flabbergasted. You can only apologize so many times. When I checked in the woman said maybe 6 words to me. I couldn't believe I was done. So I asked her to tell me a little about the hotel, where's the pool, restaurant, how do I do valet here ect....Finally she tells me. We purchased a pation room, they are remodelig. The doors had caution tape all over them and they woulld not open. What was worse is at 8 am after a long drive, the workers were on the patio banging and working. It was incredible! Westin needs to take lessons in customer service or guest services. It is such a nice chain of hotels to have incompetent people working. Invest in the training. It will help. August 3, 2012
Rated 5 out of 5 by KARswiss 3Ps. Perfect Place in Pasadena This is my third visit to this Westin, and I have been delighted . I have spend much of my life in Starwood hotels, and this one ranks up there for a hotel in center city. I write this on an ipad outside in the hotel dining room terrace, using free wifi from the Westin. The warm clear weather is a free bonus . Very quiet. Delicious turkey burger, accompanied by a bowl of fresh fruit ( and quite a variety of fruits too) is perfect . This Westin has terrific views in very direction, and is walking distance to a dozen great cafes and some of the best cappuccino in the USA. January 24, 2014
Rated 1 out of 5 by Zwizzer Why bother? You will only get upset. Too many problems here after 4-6 stays in past 3 years, this place is ruining SPG rep. Paid for upgrade room with terrace......beer bottle caps, cig butts, and urine smell on balcony with nice view of Pasadena! Baked potato with room service grizzly steak was not even lukewarm to melt butter. No shampoo or conditioner , and 20 minute wait after calling service express. Starwood has not gotten the management right in this place. Fuhgeddaboutit! August 17, 2014
Rated 1 out of 5 by UnhappyGuest123 Terrible Front Desk Management We were startled awake at 7am because someone was drilling into the walls in the room next to us, consistent drilling for an hour until I got fed up and called the front desk. The front desk manager, Kyle, said he would investigate. He called back and said he personally went to our floor to see what the source of the drilling was and could not find anything. He also stated that as the front desk manager, neither he nor his staff know of any scheduled engineering for the entire hotel that day. I peeked out of the room and sure enough, there is a maintenance man with a cart of air filters outside of the room next to ours. When we left our room to check out, the maintenance man had moved to the room directly across from ours. Why would a front desk manager claim not to know of scheduled maintenance? Westin management has either lied to me or they do not know what is going on in their own hotel. I took pictures of the maintenance cart outside our rooms. Why would Westin schedule work that requires disruptive noises so early in the morning? Kyle then asked what I think should be done. Why do I need to tell him what he should do, is this not his job? Terrible management. This hotel does not care about its guests. August 8, 2013
Rated 4 out of 5 by Qman Best sleep I've ever had! I cannot remember a more comfortable bed. Absolutely the best rest I remember in a very long time. Highly recommended. Room looked great. Staff was courteous, professional and Helpful. Parking was a bit of a pain with only a very few "full size" spaces, the rest "compact". But the location was great. Close to museums, restaurants and other sights. *Note: I did no avail myself of the restaurant on premises, but noticed it was quite busy both indoors and out. I gave it a 5 based on my observations. September 16, 2014
Rated 5 out of 5 by jik0123 Amazing staff! Even though there were some problems with my room first and a dirty sink in the second room I was switched too. The staff was amazing which made up for any initial hiccups. Hank at the front desk ran around the hotel looking for a package that was delivered to the hotel and then went missing and Kyle one of the managers on his first full day at the hotel did a great job of finding me a larger room that fit my needs. Overall I was a great experience at The Westin Pasadena and I would wholeheartedly recommend this hotel. June 16, 2013
Rated 5 out of 5 by becsterla Totally fine for our purposes We found this hotel to be totally reasonable for our needs. The heated salt water pool and jacuzzi are lovely, and each locker room has a steam and sauna. The room service is not too expensive and the food is quite good. The hotel offers a free shuttle for anything within three miles. We used it several times. My biggest complaint would be that the rooms and the lobby lack personality and a sense of warmth. Too much cool marble for our tastes. December 29, 2012
Rated 3 out of 5 by terris Good but could be better This property is a good Westin hotel but the cleanliness and offerings could be better. I am there weekly and notice they make improvements to the gym but do not keep it clean or stocked. The headphones are frequently gone, the equipment has never been cleaned (that is going on six months). The ice machine area is typically dirty. The rooms are okay but you can see this is an older property that needs help. January 30, 2012
Rated 4 out of 5 by LoyalPlatnumTraveler Poor Starwood Support... This is a solid business hotel in a great location. I have stayed here multiple times. As a longstanding Platnum / Starwood member, this hotel could care less. When I arrived, my room was not ready for check in. The rooms they had available were smaller and were actually at a lower price on the web. They offered me the smaller/lower priced room, but would not honor the lower price. When I asked about an upgrade, at first they told me they had upgraded my room. When I showed them that was the exact room I reserved with no upgrade, they told me that was all they had, but it was not ready. When I told them that they are selling bigger/upgraded rooms on the web as I stood there, they just said there is nothing they could do about that...as such Starwood/Platnum status is meaningless at this hotel. I am writing this as it has happened to me here on multiple occasions. Caveot Emptor. April 25, 2013
Rated 5 out of 5 by osat Unprofessional receptionists, unresponsive Staff i'm longtime SPG member, and have stayed at Westin Pasadena many times. On my most recent visit the receptionist just looked at me on arrival with luggage after a very long Asia flight. After 15 secs she said - can i help you? Not a welcoming word to a returning guest. Not too much to ask from a staff that is supposed to be trained in SPG recognition. 5 days after departure I checked my CC bill and noticed I was charged for using the mini bar - which I never did - and one day after checking out and settling my final bill. Calls to Accounting, Chief of Operations, and the GM went unanswered. On the whole a very disappointing experience caused by unprofessional staff service. August 11, 2014
Rated 1 out of 5 by WGuest2014 Something different (not for the best) going on at this SPG property I have stayed at this property numerous times and was previously always impressed with the courtesy of the staff and room upgrades accorded my SPG status. This stay, at Platinum level, I was first put in a patio room with no working phone, then a standard(ish) 6th floor room with very bad road noise (after waiting 40+ munites b/c someone was said to be on break instead of preparing the room), and then after that something with only marginally better road noise on the 3rd floor. Given the uninterested attitude of a particular member of the front desk staff, I gave up on the accommodations and decided to stay put. Perhaps that was not (ultimately) the best choice given the noisy AC. Geesh! August 26, 2014
Rated 5 out of 5 by TonyJung The Best Room Ever I will never look for a hotel again in Pasadena area,as it was the most wonderful stay. checkin went quick and smooth(I remembered the lady name was Lijun). Got a free upgrade. The room was huge. The halls were quite and the bed almost made one want to stay all day in it. January 18, 2014
Rated 5 out of 5 by ndello Westin does it right I will say, first time here, but very very nice stay. Room was spotless. Staff were so attentive, restaurant was great, wide variety. One complaint, I want a 2 bedroom suite which is not offered. So when I return with my family, I cannot stay, that is a bummer. January 18, 2014
Rated 4 out of 5 by BonsaiBob2013 Service Great, but Misc charges not good Service on Restaurant Patio was great; especially, Diego . I feel the wireless internet and business center charges are totally out of NORM !! What a rip-off. Also, why don't you consider courtesy coffee in the lobby ? Overall experience was Very Good. June 4, 2013
Rated 5 out of 5 by Dennis33 Great Staff This hotel is one of the best for catering to their customers. I have stayed many times and find them all very professional and I enjoy the Hotel and the food. July 25, 2013
Rated 1 out of 5 by PastorC The Room was uncomfortable I was expecting a little more with regards to seating in the room. The room size, the furniture on the balcony. The room was more fitting for a single than a couple. There was no vanity space. We would have preferred to have seating outside the bed: a set of comfortable chairs. i am not sure of the bathrobe was meant to be for only one person. the Bed did not have a fitted sheet. We spent the night adjusting the sheet to try and have a comfortable sleep. The mattress was terrible for our backs. We were hoping to stay in the room the majority of our stay, but the room was not comfortable for a long stay August 17, 2014
Rated 1 out of 5 by disappointedbride Disappointing Rose suite and construction in terrace & fountain area I booked the suite at Westin Pasadena back in November of 2012 for April as it was close to the church where I was having my wedding ceremony. I had hoped to also be able to use the Westin Pasadena and it's wonderful property to take pre-wedding photos. I had spoke to an employee in the sales office and she told me that it would be no problem. Come a week before my wedding I called in to Westin to confirm my suite and as well taking photos at the terraced lawn/fountain. To my dismay I was told that I had to reserve the terrace for photos and that there would be a charge. However, the terrace had already been reserved that day for another wedding. I was frustrated and upset at the situation particularly because I was not told about this early when I had asked the Westin Pasdena and booked my suite back in Nov. I was fine with the fee, but as I spoke with the sales manager Alma I was told there was nothing that they could do even though I had clear record of what day I spoke with the sales woman. Alma said she would try to call the couple and see if they could change their time block for pictures. Yet after several days she never returned my call which I felt was extremely unprofessional especially given that I was stressing out over my wedding already. I ended up not being able to take photos at the terrace and the day of saw that Westin had also blocked out the majority of the area for painting. I was even more disappointed by the Rose suite. It was clearly outdated, bathroom doors had scratched paint, A/C was loud and not produced a slight humidity rather than dry air, and you could see stains on the carpet in areas such as under the lounge chair in the bedroom that had been caused by the legs. For the price of the suite and being a guest of two days I will say there are better options in Pasadena and even other SPG family hotels you can choose from. My only positive comment was that the front-desk, bell hop, and valet were prompt in assisting me. I will never come back to Westin Pasadena again! April 23, 2013
Rated 3 out of 5 by David890 Over Booked, Over Priced This is not my first stay at the Westin Pasadena. It was a busy weekend in town and the room rates went up accordingly. We paid $540.00 for a room with two dbl beds. My main complaint is that they didn't make my room up when requested. I even put a call in at 3:30 in the afternoon to remind them that somehow they forgot to clean my room.. A web site advertised the Westin as the best brunch in Pasadena. The food is good and fits within the Westin philosophy of offering several healthy choices on the menu. The service, however, was poor, slow and inattentive. Would I recommend this hotel? Yes, nice facility in a great location, great gym, most of the staff are friendly and helpful. August 4, 2014
Rated 2 out of 5 by shelly111 Not up to standards The front desk help were indifferent, the fitness center was closed for repairs and the hotel was simply not up to the Westin standards I've found elsewhere. They were seriously understaffed in the dining area, so that one poor guy had to do everything. And I've come to expect some free coffee in an urn in the lobby for an early morning check out, but not here. Intead the urn is in a tiny concession area where they want to charge you extra for a cup of coffee. Not up to standards..... November 26, 2011
Rated 3 out of 5 by nbf37 Beautiful property, needs more attentive staff I was staying at the Westin for a conference. We had a number of problems getting the facilities and supplies we needed and had requested on time and with courteous response. The hotel did make it right by offering some additional food for our events, but it was a bit frustrating. The rooms and facilities were lovely and very comfortable. The wait staff in the bar/restaurant were slow and wouldn't accommodate separate checks for our breakfast one morning - this is a must for any hotel hosting a corporate event. However, sitting at the bar by the firepit in the evening was very nice. August 5, 2014
Rated 1 out of 5 by qchx uncomfortable bed, double charged my account, very cold and dry room After coming back from the vacation I checked my bank account. The hotel double charged my bill ! I called the hotel but the staff in the front dest said he couldn't help me with that so I have to call the bank myself !The bed was very uncomfortable. The heater was not working properly, sometimes it was too high and sometimes it was too low. The heater also makes the room very dry. White staying there I got sick because the heater was not working at all at night. January 22, 2013
Rated 2 out of 5 by BigGameJames Mixed bag, but ultimately disappointed Too many issues and details, but a real mixed-bag and ultimately not a good a experience especially when compared with a recent stay at the Westin Phoenix. The room was small and there was mold on the bathroom tile. Staff experience was hit and miss. Some were terrific and responsive, others had attitude and were unresponsive. I think the poor response and attitude from some staff was the most disappointing. The best thing this hotel had going was its location. January 6, 2013
Rated 3 out of 5 by Aerin This hotel has great location The housekeeping/ maintenance at the hotel has really declined the past several years. We stay at the Westin pasadena at least twice a year for a full week each time and the housekeeping staff just gets worse with each stay. I am not sure if they are short staffed or what but requests for hangers, dog bowls, toilet paper( seriously) take hours! Housekeepers are rude, several times I have been asked at 830 in the morning if we didn't need are room refreshed because our privacy tag was still up, ummmm it's 830 in the morning, yes I want my room refreshed but we are still getting dressed! Valet guys are great though!, always the same guys, very friendly, always remember us and our dogs! And are very helpful, they go above and beyond. I love the the Westin pasadena and will continue to stay here, our family lives in pasadena, so it's a very convenient December 31, 2011
Rated 2 out of 5 by disgruntled Parking is an issue The parking lot has mostly compact spaces, making it very difficult to park a larger vehicle. And then, the day after I checked out, I received a second "updated and final portfolio" that added in $28 of valet parking that I didn't use. I have been trying to get it settled with the hotel for a week and a half, but to no avail. The accounts department seems to be deliberately leaving me contentless messages after hours on the East Coast. April 8, 2013
Rated 3 out of 5 by WendyD It's OK but could be better The location of this hotel is great. My issues were with the condition of the room and the pool area. The carpet in our room was ripped and coming up. I stepped on the tack strip that holds the carpet down, which is like stepping on a nail. Thankfully it did not draw blood but there should be no reason why a Westin would have ripped carpet or exposed hazards. For the price, I expect more. In addition, the pool furniture is old. The pads on the lounge chairs are old and dirty and very uncomfortable. Not typical of a Westin hotel either. When you lay out by the pool, the restaurant exhaust fan is so close to the pool that you smell food the entire time. It's a bit overwhelming. The pool is cold as well. Ask for a room that is not over the restaurant/bar. You can hear music and people until very late at night. They need to turn down the music at 10:00. The hotel has potential but needs improvement. July 22, 2013
Rated 5 out of 5 by drmac Excellent Hotel! I had a wonderful stay at the Westin Pasadena. The facilities are beautiful, the room was very comfortable, the fitness room was the best I've ever seen in a hotel, and the staff was extremely accommodating. The only small hiccup involved procuring a microwave for my room, which I requested in advance. The staff member with whom I was in contact by email, Erwin, was generally unresponsive and I never received an apology from him when my request was not honored at check-in. However, other staff members stepped up, and I had a microwave in my room by 3:00pm the next day. The rest of the staff was TERRIFIC. (Sorry, Erwin....) Pasadena is a beautiful city, and if I ever have the opportunity to return, I will gladly stay at the Westin. August 5, 2014
Rated 2 out of 5 by Shaffer Poor example This hotel did not meet the Westin standard in the following area's Front desk Operator (am) Valet Room air conditioner Shower in working order Door security missing Very poor August 23, 2014


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Loud, Painful and Sweet!
Catching Elephant is a theme by Andy Taylor
THE PROBLEMATICS "The Kids All Suck" LP. Nice find this past weekend. This record was on the defunct-now Rip Off Records from here in San Francisco and was #32 on its catalog. The band no longer exists except on the WWW and on vinyl. I'll be spinning it on my radio show soon. Laters.


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Encaustic Mixed Media: Innovative Techniques and Surfaces for Working with Waxby Patricia Baldwin Seggebruch
Synopses & Reviews
Publisher Comments:
Plaster, shellac and tar, oh my
Rusting and burning, carving and spackling, tarring and flocking: These are just a few of the unique and surprising techniques author Patricia Trish Baldwin Seggebruch shares with you in Encaustic Mixed Media
New to encaustic? With Trish leading the way, you can start today And if you've dabbled in encaustic before, the creative approach and new materials and techniques used in this book will blow you away
Encaustic Mixed Media includes:
- Unexpected art supplies: From the craft store to the hardware store to the art supply store, author Patricia Baldwin Seggebruch shatters the conventions of what are and are not art supplies. Shellac? Yes. Tar? Sure. Drywall tape and patching plaster? Of course But it doesn't stop there. You'll mix these offbeat, unexpected materials with some others that are a tad more traditional, like decorative papers, sparkly glass bead gels and pastels.
- Embellishment mini-demos: Why use ordinary, everyday embellishments when you can make cool ones yourself? Die-cut papers, glue-molded structural elements and fire-treated papers and plastics: These are just a few of the unique embellishments you'll learn to create.
- Visual inspiration: Treat yourself to plenty of inspiring eye-candy, and savor amazing combinations of color, texture and technique. Plenty of gallery pieces throughout the book will make you want to get started right away
Encaustic Mixed Media presents a plethora of unique techniques and materials and just the right amount of expertise; you'll find beauty and surprises on every page. Add Encaustic Mixed Media to your creativity toolbox and expand your artistic horizons today
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Photo by Indira The Sphynx
"Yo, Mr. White."
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"Draw me like one of your french girls."
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Via Louca dos Gatos
"Can I play outside now?"
Photo by ©indira the sphynx - The Naked Goddess
"I want my lawyer! I'm innocent!"
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"So… Do you come here often?"
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"I think it's cozy enough now… Yep…"
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"Batman. I said BATMAN."
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"Stressed, depressed, but well dressed."
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Kat Von D's baby.
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"It's good to be the King."
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Oh, just a bunch of naked cats on bed…
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"I think you should shave your head too, mom. Bald is awesome!"
Photo via imgur
"Stop it, Nancy… People are looking. And for God's sake, put on some clothes."
Photo by ©Nada N Nada


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CES 2011: HP Enters the Tablet Ring
With this much hype surrounding a tablet, you'd think that it came from atop Mount Sinai with a little less than a dozen laws on it. It seems that Palm and Hewlett-Packard have decided to enter the already crowded tablet market, and early schematics of their iPad-like product have already hit the Internet. HP joins a fight with Apple and Google? Let the games begin!
According to Fox News, who secured the exclusive on the HP tablet blueprints, the PalmPad is about the same size and weight as the iPad. However, thanks to features such as HDMI and USB 3.0 ports, the PalmPad seems more widely compatible with other devices than its Apple rival. Additionally, HP's tablet will run a Microsoft operating system, putting Android and iOS into a three-way fight for market dominance.
Or is it a four-way fight? RIM is almost certainly going to deliver a BlackBerry tablet sooner rather than later, creating a royal rumble of tablet formats, sizes, prices, operating systems, capabilities and software. Over at InformationWeek, Eric Zeman wonders if that presents too much choice to consumers, and postulates that without a serious showing next year, Windows and RIM may find themselves pushed out of the market by early entrants Google and Apple .
Only a couple more weeks, and we'll be able to judge firsthand which tablet reigns supreme.


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Journal Entries
Christmas all arranged (GB)
Posted Dec 25, 2011
...at Gordon's house!
All I've had to do this morning is get ready to be waited upon
My #1 daughter and her family are joining us for lunch but they are spending some time this morning at the cemetery as Karl has lost his Nanna and mother this year
I'm coming home tomorrow to shower and change for my sister's annual Boxing Day party, I'll be seeing daughter #2 and #1 son, along with his family there, I bet Jaxon has doubled in size (he is 1 in a fortnight!) - I'll be driving, taking Andrew, Wenzel (Gordon's German student) and Gordon so he can relax and have a or several, Mauro has gone home to Italy to spend the festivities with his family.
I hope wherever you are and whatever you're doing, you're spending the festive season with loved ones and having fun. My thoughts are with friends who aren't well and some are fighting cancer.
I wish you all a happy and prosperous New Year, may 2012 be good to us all
Discuss this Journal entry [2]
Latest reply: Dec 25, 2011
December - all change! (GB)
Posted Dec 1, 2011
My family allowance payments end on Monday, that's 33 years I've been claiming it. Later this month Andrew is moving out (his choice) and I will be living alone for the first time ever. Well, not quite, I will have Goldie with me. I'll be remodelling the rooms in the bungalow. Andrew got the largest bedroom when we moved here, I got #2 which has 3 exposed walls. Later I had patio doors put in my bedroom and they took the place of the window and radiator. I regularly wake up with a cold nose
As soon as he's gone, I'm gutting his room then decorating. Then moving my bedroom furniture in so I can have a toasty quiet bedroom!
In my old room I will decorate then put my dining table & chairs in there, so I can have a bit more space in my living room. I'd like a corner unit on the far back wall so I can finally dispose of my 18 year-old couch. Might replace the 36 year-old coffee table too.
enjoying looking forward to 2012
Discuss this Journal entry [14]
Latest reply: Dec 1, 2011
Thick boned
Posted Nov 20, 2011
I consider myself very lucky to have thick bones. In the first week of September I had an accident and badly bruised my leg. It is almost healed now, almost 3 months on, still pinky and lumpy, but I've been massaging it and it seems to be finally dispersing. People who have seen it in the duration have remarked that it's a miracle I didn't break my leg. I've never broken a bone (touch wood) and I know I'm only here today because I have a thick skull (stop giggling at the back). I was just telling Gordon this morning that when I was a child I used to jump from one to the other of the huge concrete-cubed "tank deterrents" on Cleethorpes beach, along with all the other kids. One day I missed the target and fell backwards - cracked my head - and opened my eyes feeling as light as a feather - I thought I had died and could fly. Only when a lady stranger appeared above me (I was laid on the sand) and asked me if I was alright did I realise I was still alive.
Discuss this Journal entry [23]
Latest reply: Nov 20, 2011
Armistice Day 11.11.11
Posted Nov 11, 2011
I think most people here know my thoughts, particularly as I'm the daughter of a Normandy Veteran. I couldn't be more proud of my father or others who stand up for what they believe. I too don't want any more wars but sometimes there's no choice (war on terror) and then there's peace to maintain
My mother is now 92 and she will be laying a poppy wreath on Sunday on behalf of the France and Germany Star, as she's done for the last 5 years, having taken the duty over from my father.
No-one in the UK is expected or forced to wear a poppy or participate in the 2 minutes' silence. That's called freedom of choice and I also would like my views respected. Thank you.
Discuss this Journal entry [16]
Latest reply: Nov 11, 2011
Badmintonathon (World record smashed)
Posted Oct 24, 2011
That's my son (Allan Ogle).
His team smashed the world record for playing Badminton non-stop and raised funds for the NSPCC. There are pictures and even a video of the last few moments on Facebook, can't post them here, sorry.
Discuss this Journal entry [10]
Latest reply: Oct 24, 2011
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TUESDAY, Nov. 5 (HealthDay News) -- New research suggests that men who take testosterone supplements after undergoing a minor cardiac procedure are more likely to suffer strokes, heart attacks or die.
But it's not clear if there's truly an extra risk for these men. And urologists aren't calling for caution beyond the usual warnings about potential overuse of testosterone supplements.
"The investigators simply do not know all of the potential differences between the men who were treated with testosterone and those who were not," said Dr. Bradley Anawalt, an endocrinologist and chief of medicine service at the University of Washington Medical Center in Seattle. He was not involved with the study.
VA Eastern Colorado Health Care System cardiologist Dr. P. Michael Ho, a study co-author, acknowledged that the results don't confirm that testosterone supplements are especially risky for men with suspected heart problems. However, "this hopefully provides information that doctors can use when they discuss with their patients about whether to start or continue testosterone therapy," he noted.
Testosterone therapy has become a hot topic in doctor's offices in recent years as late-night TV ads warn male viewers that "low T" could explain fatigue and low libidos. A study earlier this year found that the use of testosterone therapy by U.S. men aged 40 and up tripled between 2001 and 2011.
Some urologists and endocrinologists warn that doctors are overprescribing the supplements, which can cost thousands of dollars a year and are linked to side effects such as blood clots, male breast growth and infertility.
In the new study, researchers looked at the medical records of more than 8,700 men in the United States who underwent angiographs, a procedure that uses scans to examine blood flow in the body. Angiographs are different from angiograms, in which doctors send catheters up into an artery to determine whether blood vessels are clogged.
All of the men in the study had testosterone levels that were considered to be on the low side; on average, the men were in their early 60s. A total of 1,223 of the men used testosterone therapy after their angiographs.
The researchers tracked the men for an average of 28 months and adjusted the study's statistics so they wouldn't be thrown off by high or low numbers of men with heart disease (almost all had signs of it). The investigators found that the men in the study were about 30 percent more likely to suffer a heart attack or stroke and to die after going on testosterone therapy, although these conditions weren't extremely common overall. (Nine percent of the men died.)
The study has limitations. It's not clear why men who went on testosterone therapy sought it in the first place. And the study didn't examine the benefits that the treatment could have brought to the men in terms of things like their sex lives, energy levels and overall happiness.
Study co-author Ho pointed out that the researchers tried to account for the possible effect of health conditions such as diabetes. It's conceivable that testosterone supplements could worsen sleep apnea and boost the risk of blood clots, he suggested.
Dr. John Amory, a professor of medicine at the University of Washington Medical Center, said the findings shouldn't worry people because they could easily be misleading. But they do point to the importance of research that will do a better job of identifying any risks from testosterone supplements. "The final verdict will wait," he said.
Amory added that testosterone treatment is definitely a good idea in certain cases, such as in a young man who's lost his testicles to cancer. In other men, especially those who are older and sicker, it's not as clear that the benefits outweigh the risks, he said.
The study appears in the Nov. 6 issue of the Journal of the American Medical Association.
More information
For more about testosterone, try the U.S. National Library of Medicine.
SOURCES: Bradley Anawalt, M.D., endocrinologist and chief, medicine service, University of Washington Medical Center, Seattle; P. Michael Ho, M.D., M.P.H., staff cardiologist, VA Eastern Colorado Health Care System, Denver; John Amory, M.D., professor, medicine, University of Washington Medical Center, Seattle; Nov. 6, 2013, Journal of the American Medical Association
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Los Angeles Archdiocese kept sexual abuse in the shadows » Father Lynn R. Caffoe » Exhibit 52, Pages 75-76
Exhibit 52, Pages 75-76 by SGVNews
Man fighting charges for painting Main Street
BURGETTSTOWN, Pa. (AP) — A western Pennsylvania man will hire an attorney and fight a criminal mischief charge for painting the speed limit on a stretch of Main Street. Full Story
John Denver gets star on Hollywood Walk of Fame
LOS ANGELES (AP) — Things are a little sunnier on the Hollywood Walk of Fame following the posthumous unveiling of a star for John Denver. Full Story
(AP Photo/John Bazemore, File)
'Here Comes Honey Boo Boo' canceled
TLC axes show after evidence surfaces that star Mama June had resumed a romance with a convicted child molester.


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