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- In silico polypharmacology: retrospective recognition vs. rational design (2014)
- Oral presentation 9th German Conference on Chemoinformatics Fulda, Germany. 10-12 November 2013. The "one drug – one target – one disease" paradigm in drug discovery has been reconsidered during the last decade...
- 9th German Conference on Chemoinformatics [: introduction] (2014)
- Introduction to the supplement: 9th German Conference on Chemoinformatics, GCC2013
- Topographic embedding of MOR18-2 in the mouse olfactory bulb (2014)
- Poster presentation at 1st International Workshop on Odor Spaces. Mice are exceptional in their ability to capture their chemical environment, mapping the olfactory world into a basic sensory representation with over one thousand different types of chemical sensors, that is, olfactory sensory neurons (OSNs). OSNs of each type converge in the olfactory bulb onto exclusive distinct physiological areas called glomeruli. The glomeruli constitute the first relay station of olfactory stimulus representation in the mouse brain. Thus, the stimulus induced glomerular input pattern spatially embodies an important part of the sensory representation in the olfactory bulb. Still, topographic organization principles (chemotopy, tunotopy) are under debate. One reason might be that investigation are, due to experimental limitations, only performed on stimuli sets in the size of one hundred odors. But this represents only a tiny snapshot of the vast amount of molecules in the olfactory world and topographic relationships might be disguised in the incomplete representation of molecular receptive ranges (MRR). Therefore we investigated the problem with the MOR18-2 glomerulus as point of reference: First we determined it's MRR. Then, based on a measurement set covering this MRR, we elucidated the topographic embedding. It shows that MOR18-2 is embedded in a hierarchy of patchy tunotopic domains.
- The emergence of cohorts of co-active neurons in random recurrent networks provides a mechanism for orientation and direction selectivity (2014)
- Poster presentation at The Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014: We study random strongly heterogeneous recurrent networks of firing rate neurons, introducing the notion of cohorts: groups of co-active neurons, who compete for firing with one another and whose presence depends sensitively on the structure of the input. The identities of neurons recruited to and dropped from an active cohort changes smoothly with varying input features. We search for network parameter regimes in which the activation of cohorts is robust yet easily switchable by the external input and which exhibit large repertoires of different cohorts. We apply these networks to model the emergence of orientation and direction selectivity in visual cortex. We feed these random networks with a set of harmonic inputs that vary across neurons only in their temporal phase, mimicking the feedforward drive due to a moving grating stimulus. The relationship between the phases that carries the information about the orientation of the stimulus determines which cohort of neurons is activated. As a result the individual neurons acquire non-monotonic orientation tuning curves which are characterized by high orientation and direction selectivity. This mechanism of emergence for direction selectivity differs from the classical motion detector scheme, which is based on the nonlinear summation of the time-shifted inputs. In our model these two mechanisms coexist in the same network, but can be distinguished by their different frequency and contrast dependences. In general, the mechanism we are studying here converts temporal phase sequence into population activity and could therefore be used to extract and represent also various other relevant stimulus features.
- Modeling the effects of neuronal morphology on dendritic chloride diffusion and GABAergic inhibition (2014)
- Poster presentation at the Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014. Gamma-aminobutyric acid receptors (GABAARs) are ligand-gated chloride (Cl−) channels which mediate the majority of inhibitory neurotransmission in the CNS. Spatiotemporal changes of intracellular Cl− concentration alter the concentration gradient for Cl− across the neuronal membrane and thus affect the current flow through GABAARs and the efficacy of GABAergic inhibition. However, the impact of complex neuronal morphology on Cl− diffusion and the redistribution of intracellular Cl− is not well understood. Recently, computational models for Cl− diffusion and GABAAR-mediated inhibition in realistic neuronal morphologies became available [1-3]. Here we have used computational models of morphologically complex dendrites to test the effects of spines on Cl− diffusion. In all dendritic morphologies tested, spines slowed down longitudinal Cl− diffusion along dendrites and decreased the amount and spatial spread of synaptically evoked Cl− changes. Spine densities of 2-10 spines/µm decreased the longitudinal diffusion coefficient of Cl− to 80-30% of its value in smooth dendrites, respectively. These results suggest that spines are able to limit short-term ionic plasticity [4] at dendritic GABAergic synapses.
- Connexin 37 and Connexin 43 genotypes in correlation to cytokines in induced sputum and blood in cystic fibrosis (CF) (2014)
- Meeting abstract: Abstracts of the 50th Workshop for Pediatric Research We have provided evidence in former studies that cytokines (IL-8, TNF alpha, LBP, TGFß) measured in blood correlate negatively with lung function in deltaF508 homozygous patients...
- Synaptic boutons sizes are tuned to best fit their physiological performances (2013)
- Poster presentation: Twenty Second Annual Computational Neuroscience Meeting: CNS*2013. Paris, France. 13-18 July 2013. To truly appreciate the myriad of events which relate synaptic function and vesicle dynamics, simulations should be done in a spatially realistic environment. This holds true in particular in order to explain as well the rather astonishing motor patterns which we observed within in vivo recordings which underlie peristaltic contractionsas well as the shape of the EPSPs at different forms of long-term stimulation, presented both here, at a well characterized synapse, the neuromuscular junction (NMJ) of the Drosophila larva (c.f. Figure 1). To this end, we have employed a reductionist approach and generated three dimensional models of single presynaptic boutons at the Drosophila larval NMJ. Vesicle dynamics are described by diffusion-like partial differential equations which are solved numerically on unstructured grids using the uG platform. In our model we varied parameters such as bouton-size, vesicle output probability (Po), stimulation frequency and number of synapses, to observe how altering these parameters effected bouton function. Hence we demonstrate that the morphologic and physiologic specialization maybe a convergent evolutionary adaptation to regulate the trade off between sustained, low output, and short term, high output, synaptic signals. There seems to be a biologically meaningful explanation for the co-existence of the two different bouton types as previously observed at the NMJ (characterized especially by the relation between size and Po), the assigning of two different tasks with respect to short- and long-time behaviour could allow for an optimized interplay of different synapse types. We can present astonishing similar results of experimental and simulation data which could be gained in particular without any data fitting, however based only on biophysical values which could be taken from different experimental results. As a side product, we demonstrate how advanced methods from numerical mathematics could help in future to resolve also other difficult experimental neurobiological issues.
- Learning more by sampling less: subsampling effects are model specific (2013)
- Poster presentation: Twenty Second Annual Computational Neuroscience Meeting: CNS*2013. Paris, France. 13-18 July 2013. When studying real world complex networks, one rarely has full access to all their components. As an example, the central nervous system of the human consists of 1011 neurons which are each connected to thousands of other neurons [1]. Of these 100 billion neurons, at most a few hundred can be recorded in parallel. Thus observations are hampered by immense subsampling. While subsampling does not affect the observables of single neuron activity, it can heavily distort observables which characterize interactions between pairs or groups of neurons [2]. Without a precise understanding how subsampling affects these observables, inference on neural network dynamics from subsampled neural data remains limited. We systematically studied subsampling effects in three self-organized critical (SOC) models, since this class of models can reproduce the spatio-temporal activity of spontaneous activity observed in vivo [2,3]. The models differed in their topology and in their precise interaction rules. The first model consisted of locally connected integrate- and fire units, thereby resembling cortical activity propagation mechanisms [2]. The second model had the same interaction rules but random connectivity [4]. The third model had local connectivity but different activity propagation rules [5]. As a measure of network dynamics, we characterized the spatio-temporal waves of activity, called avalanches. Avalanches are characteristic for SOC models and neural tissue [6]. Avalanche measures A (e.g. size, duration, shape) were calculated for the fully sampled and the subsampled models. To mimic subsampling in the models, we considered the activity of a subset of units only, discarding the activity of all the other units. Under subsampling the avalanche measures A depended on three main factors: First, A depended on the interaction rules of the model and its topology, thus each model showed its own characteristic subsampling effects on A. Second, A depended on the number of sampled sites n. With small and intermediate n, the true A¬ could not be recovered in any of the models. Third, A depended on the distance d between sampled sites. With small d, A was overestimated, while with large d, A was underestimated. Since under subsampling, the observables depended on the model's topology and interaction mechanisms, we propose that systematic subsampling can be exploited to compare models with neural data: When changing the number and the distance between electrodes in neural tissue and sampled units in a model analogously, the observables in a correct model should behave the same as in the neural tissue. Thereby, incorrect models can easily be discarded. Thus, systematic subsampling offers a promising and unique approach to model selection, even if brain activity was far from being fully sampled.
- Less invasive surgery of the proximal aorta (2013)
- Oral presentation: 23rd World Congress of the World Society of Cardio-Thoracic Surgeons. Split, Croatia. 12-15 September 2013. Background: Partial upper sternotomy (PUS) is established less invasive approach for single and double valve surgery. Reports of aortic surgery performed through PUS are rare. Methods: The records of 52 patients undergoing primary elective surgery on the proximal aorta through PUS between 2005 and 2011 were reviewed. Patients mean age was 57 years, 35% were in NYHA Class III or IV, 59% had recent cardiac decompensation, and 17% had pulmonary hypertension. The PUS was taken down to the 4th left intercostal space in 44 patients (85%). Results: No conversion to full sternotomy was necessary. The aortic cross-clamp, cardiopulmonary bypass and operative times averaged 136 ± 20 min., 186 ± 36 min. and 327 ± 83 min., respectively. In eight patients, the right axillary artery was cannulated for establishing cardiopulmonary bypass; the others were cannulated centrally. All patients except one received a procedure on the ascending aorta, either replacement in 30 (58%) or reduction aortoplasty in 21 (40%). Aortic root replacement was additionally performed in 31 patients (60%), including David in 20 (38%) and Ross procedure in 6 (11.5%). The aortic arch was replaced either partially in 5 (10%) or totally in 3 (6%) patients, in moderate hypothermia employing antegrade cerebral perfusion. Additional procedures, included mitral valve repair in 15 (29%) patients and coronary grafting. Ventilation time, intensive care unit and hospital stay averaged 17 ± 12 hours, 2 ± 1, and 11 ± 9 days. Chest drainage was 470 ± 380 ml/24 hours. Permanent neurologic deficit did not occur. Wound dehiscence was observed in a single patient (2%). Thirty-day and hospital mortality were not observed. Conclusions: Less invasive surgery on the aortic root, ascending aorta and aortic arch can be performed safely and reproducibly. Potential benefits include a minimized risk of wound dehiscence and reduced postoperative bleeding. The PUS does not compromise the quality of the operation.
- Durability of mitral valve reconstruction using the cosgrove edwards annuloplasty band at 5 years (2013)
- Oral presentation: 23rd World Congress of the World Society of Cardio-Thoracic Surgeons. Split, Croatia. 12-15 September 2013. Background: In the past, questions have been raised, whether an open flexible annuloplasty band can reliably prevent recurrent mitral valve regurgitation. The purpose of this study was to evaluate the durability of mitral valve repair at midterm, using the Cosgrove-Edwards annuloplasty band in a homogenic patient cohort. Methods: From January 2004 to December 2007, 157 consecutive patients with degenerative mitral valve disease were included in the study. All had quadrangular resection of a P2 prolapse and annuloplasty with a Cosgrove-Edwards annuloplasty band. Clinical and echocardiography follow-up was complete. Results: There was no intraoperative or 30 day mortality. After a mean follow-up of 5.0 ± 1.9 years, survival was 94.3%. At midterm, freedom from reoperations was 98.9%, freedom from thromboembolism was 97.5% and freedom from endocarditis was 99.4%. Echocardiography follow-up showed recurrent mitral valve regurgitation higher than grade 2 in two patients. Mean ejection fraction was 60.3 ± 10.2%, left atrial diameter was 42 ± 7 mm, mean gradient was 3.2 ± 1.4 mmHg, effective orifice area was 3.3 ± 1.3cm², mitral leaflet coaptation length was 7.5 ± 1.9 mm and mitral leaflet tethering height was 6.2 ± 2.3 mm. Conclusion: Mitral valve repair using the Cosgrove annuloplasty band for degenerative mitral valve disease provides an effective and durable form of reconstruction.


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Where did the German Moser family come from? What is the German Moser family crest and coat of arms? When did the Moser family first arrive in the United States? Where did the various branches of the family go? What is the Moser family history?
Spelling variations of this family name include: Moser, Mosier, Moeser, Moesier, Mosser, Mozer and others.
First found in Swabia, where the name became noted for its many branches within the region, each house acquiring a status and influence which was envied and enrolled by the princes of the region. Chronicles first mention Rudolph in dem mose of Wuerttemberg in 1269, and Hainrich in dem Mos of Tyrol in 1379. In their later history the family became a power unto themselves and were elevated to the ranks of nobility as their influence grew.
This web page shows only a small excerpt of our Moser research. Another 361 words(26 lines of text) covering the years 1482, 1534, 1558, 1573, 1574, 1606, 1701, 1715, 1759, 1764, 1765, 1785, and 1818 are included under the topic Early Moser History in all our PDF Extended History products.
Another 57 words(4 lines of text) are included under the topic Early Moser Notables in all our PDF Extended History products.
Some of the first settlers of this family name were:
Moser Settlers in the United States in the 17th Century
Moser Settlers in the United States in the 18th Century
Moser Settlers in the United States in the 19th Century
The Moser Family Crest was acquired from the Houseofnames.com archives. The Moser Family Crest was drawn according to heraldic standards based on published blazons. We generally include the oldest published family crest once associated with each surname.
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The EU and the USA share a common approach on the need to promote open, transparent, competitive and sustainable global energy markets, and have been co-operating in the energy sector for many years.
In June 2009, this co-operation was given a boost with the proposal of the USA to establish an EU-US Energy Council. The agreed terms of reference of the Council are broad and designed to bring together all key actors working on energy issues on both sides of the Atlantic, in three areas for which corresponding working groups were established: Energy security, Energy technologies research and Energy policy.
Commissioner Oettinger visits the United States
From 15 July until 18 July 2013 Commissioner Oettinger is visiting the United States. Among the highlights of his visit are meetings with Ambassador Carlos Pascual, special envoy and coordinator for international energy affairs at the US State Department, US Trade Representative Michael Froman and Tommy Beaudreau, the first director of the Bureau of Ocean Energy Management (BOEM), which is responsible for overseeing the development of the US's offshore resources. At the Centre for Strategic and International Studies the Commissioner delivers a speech on the transatlantic energy revolution.
A visit to a site for exploration and production of shale gas in the vicinity of Fort Worth (Texas) and a meeting with Texas state and municipal regulators on fracking conclude the trip.
There have been five EU-US Energy Council ministerial meetings:
On 2 April 2014, the fifth meeting took place in Brussels one week after the EU-US Summit.
On 5 December 2012, the fourth meeting took place in Brussels.
Handshake between Hillary Clinton and Günther Oettinger
On 28 November 2011, the third meeting took place in Washington just before the EU-US Summit and the day before the meeting of the Trans-Atlantic Economic Council.
On 19 November 2010, the second meeting took place in Lisbon, the day before the EU-US Summit.
In November 2009, the establishment and objectives of the EU-US Energy Council was agreed at the EU-US Summit in Washington and a first inaugural meeting took place in the margins of the Summit.
On 14 June 2013, Member States gave the European Commission the green light to start trade and investment talks with the United States. This builds on the report of a High Level Working Group on Jobs and Growth that was published in February 2013. The first round of talks took place during the week of 8-12 July 2013 and followed the official launch of the negotiations announced by US President Barack Obama, President of the European Commission José Manuel Barroso, President of the European Council Herman Van Rompuy and UK Prime Minister David Cameron at the G8 Summit held on 17 June 2013. Following this first round, the Commission made available, on 16th July, a number of its initial position papers, including one on raw materials and energy .
Further details concerning TTIP can be found on the following webpage of DG TRADE
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On 17 November 2010, a trans-Atlantic expert workshop on Electric Vehicles and Grid Connectivity was held in Brussels organised jointly by the European Commission, the Belgian Presidency of the EU, the Swedish Government and the US Department of Energy.


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This second volume of English Wycliffite sermons is an edition of the sermons for the Proper and Common of Saints together with two Wycliffite tracts. It is intended to be used with close reference to Volume 1, comprising the sermons on Sunday Epistles and Gospels, which appeared in 1983. The sermons form part of a complete sermon cycle preserved in part or as a whole in the thirty-one manuscripts described in Volume I. The tracts are also preserved, mainly - but not exclusively - in these same thirty-one manuscripts. The two-part introduction to this volume contains an account of five additional manuscripts, and also a discussion of the textual history of the sermons in the Sanctorale and of the tracts. The latter complements the material on the Sunday Epistles and Gospels already published, and when the edition is complete, it will set the history of the Sanctorale in the context of the whole cycle. The sermons are of great interest not only in their handling of Lollard ideas but also in their utilization of theological and scientific ideas; they indicate the level of sophistication expected of their readers.
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The author of Londonopolis: A Curious History of London picks ten of its most unusual inhabitants, including including the real-life inspiration for a Bond villain, the artist that even Turner felt inferior to and the pattern-cutter who took the fashion world by storm.
Autumn's natural wonders, even in a city like London, can offer all manner of fun and adventure this half-term, suggests Laura from our Royal Festival Hall shop.
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Deep House Vocals Vol 2 + Autumn Sale + Latest Packs @ ProducerLoops.com'Deep House Vocals Vol 2' continues this series of versatile House vocal sample packs, bringing you five fully-featured Construction Kits, complete vocal performances and individual vocal phrases for your next Deep House production. These chart-ready vocals and Construction Kits were inspired by Clean Bandit, Disclosure, Jess Glynne, and Mr Probz. Powerful bass lines, plucks, floating pads and pounding drums form the core of these stunning tracks.


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Party boat with a ton of college students going booze cruising. Most of the girls are naked and a hungry guy gets a free, dirty hot dog.
Party boat with a ton of college students going booze cruising. Most of the girls are naked and a hungry guy gets a free, dirty hot dog.
Cleaning Has Never Been More Fun
Fuck, that's a hell of a way to mop a floor. It's inspiring really. So how exactly would one apply this kind of creativity to cleaning up their bathroom? I've got shit stains on my toilet dating back from 1997 and the only way I'm gonna get off my ass and do something about it is if it involves a naked woman.
Views: 1,913,344 | Date: 11.3.08 | Submitted By Anonymous | Category: Bizarre
Damn. I could really use some service like this. At 325 pounds, I'm lucky if I can even find my cock, let alone put it to use. Sign me up for 2 whores, along with 4 beefcakes to handle all movement.
Views: 1,896,088 | Date: 11.2.08 | Submitted By Anonymous | Category: LULZ
It's not your typical work-related injury, but these things do happen... especially when someone is intentionally thrusting their foot into your vagina. It could've been worse - a flesh wound via jagged toenail... that would've put her out of work for good.
Views: 1,219,835 | Date: 10.26.08 | Submitted By Anonymous | Category: Porn Bloopers
Her vagina looks a lot like a baseball mit, same color too. If you're gonna be 69'ing her with you on bottom, do yourself a favor and bring along a snorkel.
Views: 1,138,837 | Date: 10.24.08 | Submitted By Anonymous | Category: Beef Curtains
This one is a little open-ended. There's no money shot or anything, which gives us the opportunity to use our imaginations and draw our own conclusions. Perhaps she had a prolapse, ran off the set in humiliation, then went flat broke and turned to prostitution? Sounds about right to me.
Views: 2,061,121 | Date: 10.22.08 | Submitted By Anonymous | Category: Painal
Get The Fuck Away From My Tits
Diane here follows orders. I like that. I wonder if she'd comply if I told her to sit on my face and giggle like a school girl? Probably not. She'd likely just bitch slap me like she did to the douche bag in this video.
Views: 1,213,259 | Date: 10.21.08 | Submitted By Anonymous | Category: Groped
LOL @ the dialogue and fap fap fap @ the forced cunnilingus. I love these variety videos. DOWNLOAD FULL VIDEO HERE.
Views: 2,204,111 | Date: 10.20.08 | Submitted By Anonymous | Category: Vintage
This is why I carry a 12oz bottle of my mace in my center console. Rest stops are great for quick 'on the road' jackoff sessions but they're almost always laden with dirty old men looking to score free peep shows. If they want to see me make love to myself, they gotta pay... otherwise it's mace to the face.
Views: 785,406 | Date: 10.19.08 | Submitted By Anonymous | Category: Busted!
Intentionally Caught Jacking Off
He very well might end up getting banned from every Motel 6 across the country, but eventually one of these fat Hispanic maids will do the right thing and finish the man off - just like in the porno films.
Views: 1,920,974 | Date: 10.15.08 | Submitted By Anonymous | Category: Exhibition
Indian Girl Almost Quits Anal Scene
These girls only do anal cause it lands them an extra $200 on their paycheck. That's a lot like getting paid $1,000 to go down on a 400 pound lady & then being offered an extra $100 to toss her wart-infested salad. It's just not worth it. But while were on the subject of bargains, for $2.95 you can download the full 40 minute version of this fucked up video... and trust me, it gets a lot more fucked up. Just click HERE an fap away.
Views: 3,106,897 | Date: 10.14.08 | Submitted By Anonymous | Category: Painal
No Bitch I Aint Eating Your Pussy
She tries to blame the fowl taste on the lube but that doesn't really explain the cheese whiz dripping out of her pussy. Douche with hydrogen peroxide + Mentos and get on with the show.
Views: 1,405,294 | Date: 10.11.08 | Submitted By Anonymous | Category: Porn Bloopers
Butthole Damaged After Anal Sex
Here's yet another video of a woman suffering from bodily damage after granting a large cock permission to penetrate her brown eye. To be honest, I think this one is a tranny but that's besides the point. I want to know where those 2 giant raisins dangling from her asshole came from?
Views: 1,958,739 | Date: 10.10.08 | Submitted By Anonymous | Category: Painal
Inglorious Glory Hole
Views: 47,426
Finally Found Her G Spot
Views: 153,954
Good Girl Goes Black
Views: 247,755
Anal Makes Her Cry
Views: 145,012
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Originally Posted by Kish
Pantless would mean Roy not panting like a dog. The article of clothing is called "pants," not "pant."
Well, I know the word is pants, but pantsless just sounds... off.
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Bon Voyage, Charlie Brown (and Don't Come Back!!) is a 1980 animated film produced by United Feature Syndicate for Paramount Pictures, directed by Bill Mel�ndez, and the fourth and final (to date) in a series of movies based on the Peanuts comic strip.Charlie Brown's school has accepted two French exchange students, and Linus and Charlie Brown will be going over to France as foreign exchange students, with Snoopy and Woodstock in tow, along with Peppermint Patty and Marcie from their school. The same day, Charlie Brown gets a letter from France that Marcie reads as an invitation to stay at a chateau: the Chateau du Mal Voisin, or "The House of the Bad Neighbor".They initially arrive in London, where Snoopy breaks off from the group to have his own adventures at Wimbledon to do his John McEnroe impression while the rest of the Peanuts do sightseeing before heading off to France.Upon arriving in France, Marcie and Peppermint Patty stay at a farm with another student, and Charlie Brown and Linus continue to the chateau, where there are no lights on and no answer at the door, so they must stay outside. Food and blankets are sneaked outside by Violette, the young girl who invited Charlie Brown and is defying her uncle, known as "The Baron", to be hospitable to Charlie Brown and Linus. Before long, Violette is able to explain her secret and The Baron even mellows his inhospitable attitude.The 1983 TV special What Have We Learned, Charlie Brown? serves as a sequel of sorts, with the gang visiting WWI and WWII memorials on their way back to London from France. The special earned a Peabody Award.


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Last day everyone!!! I'll be there a little later. :) #newyork #art #artgallery @lyonswiergallery
In my dreams, attached to strings and other things, we soar away. Nothing but you and I seeing the world in an entirely different light. Nothing but you and I. In my dreams attached to strings and other things, we soar away. Always discovering new wonderments and creating new memories. In my dreams attached to strings and other things, you are always by my side. Always ready to catch me when I fall. Always ready to explor in this thing…attached to strings and other things…I am in love.
Exploring new things in this big ole world with me. Sometimes it's the little things that are the biggest deals. (at W24th St And 10th Ave)
@lyonswiergallery piece by @borisbernard I spy with my little eye my evil twin. (at Lyons Wier Gallery)
Tomorrow it begins! #free at Lyons Weir Gallery in #ny from 6-9. Come and enjoy the festivities! Yes, it's also the only date that I will be an installation as well.


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That really sucks that he is leaving you hanging. What puzzles me is the actual damage -- it just doesn't seem too plausible that very isolated damage could occur from rough handling in transit with no other visible damage elsewhere on the headphone. I noticed he had a couple of other less than satisfied buyers in his feedback FWIW. Hope your claim with DHL works out.
4/15/12 at 7:32pm


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Bumble & Bumble • Super Rich Conditioner • Conditioner
(205 reviews)
|Average Rating.
|Would buy this product again.
*TOP REVIEWER* joey_s on 6/1/2011 9:01:00 PM more reviews by joey_s
Age: 36-43 Skin: Acne-prone, Fair-Medium, Neutral Hair: Brunette Eyes: Green
I absolutely adore the smell of this -- kind of a clean, lightly buttery or creamy soft floral. So many people on here comment that they don't like the smell. Then again I hate those strong, cloying, very synthetic-smelling products that are so prevalent in most commonly-used popular brands these days. This smells special and luxurious to me. B&B Gentle shampoo smells like this. Love it, hope they never change it. As far as performance goes, I think it's a great, everyday conditioner, not super moisturizing like a masque because it's not a masque, but a great daily conditioner that doesn't seem to build-up. I'd give this a 3.75 stars if I could.
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We_Say_Nevermore on 5/28/2011 7:10:00 AM more reviews by We_Say_Nevermore
Age: 25-29 Skin: Other Hair: Other Eyes: Other
I bought this because it got such good reviews, but it's really not anything special, especially when you consider the price. It's not very thick and it takes a lot to coat my hair. After about a month of use, I haven't noticed any change to my hair.
When this product runs out, I'm going to go back to the Neutrogena Triple Moisture deep conditioner from the drug store.
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jkpesaturo on 4/13/2011 8:05:00 AM more reviews by jkpesaturo
Age: 36-43 Skin: Normal, Fair-Medium Hair: Brown Eyes: Brown
I must admit that I was impressed with this conditioner. I have fine hair and I thought it would be to heavy. In-fact, it does not weigh my hair down at all. Extremely happy! I cannot stand Kerastase products as they dry my hair out completely and it becomes poofy. I use this with B&B's Quenching Shampoo and I like the results. The price is not "over-the-top"for a quality salon product.
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*TOP REVIEWER* LucySnow on 3/24/2011 1:45:00 PM more reviews by LucySnow
Age: 36-43 Skin: Combination, Fair Hair: Brunette Eyes: Hazel
Totally underwhelmed by this conditioner. It detangles well and probably moisturizes as good as your basic drugstore conditioner, but that's about it. Not worth the price. My colored, dry, frizz-prone, regularly flatironed hair needs more.
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*TOP REVIEWER* rachelbobco on 11/9/2010 7:45:00 PM more reviews by rachelbobco
Age: 30-35 Skin: Combination, Fair-Medium, Warm Hair: Brown, Curly, Medium Eyes: Green
This is my HG conditioner. I have wavy/curly hair which is very very hard to detangle. Its especially tough to comb through the bedhead tangles in the morning and this is literally the very best conditioner to detangle my hair. I've tried a lot lot lot of different conditioners, because my hair is curly and coarse and tends to tangle. I use leave in conditioners and spray on conditioners, but when conditions are desperate I rely on this. Its expensive as hell and I wish there were a cheaper product that works as well, but so far I haven't found it.
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shortieumpkin on 10/11/2010 11:41:00 PM more reviews by shortieumpkin
Age: 25-29 Skin: Combination, Fair Hair: Blond Eyes: Blue
Have tried this off and on.... so much hype that I think it will be better the next time around. It just isn't worth it at all. I get the same results with Pantene.
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*TOP REVIEWER* happygirl1 on 7/6/2010 5:25:00 PM more reviews by happygirl1
Age: 30-35 Skin: Combination Hair: Brown Eyes: Hazel
I love this stuff, granted I've only used it a couple of times (can't use it for every wash because it's so freakin' expensive!).. but it smells.. GROSS. Very plastick-y, but doesn't linger when hair is dry, thankfully. I pair it with the Gentle shampoo, and then use the Styling Lotion spray afterward - great combo. I actually add in some Kerastase Nectar Thermique after the spray, for extra heat protection (I blow dry). The frizzies were kept at bay, even near the beach area which tends to be quite humid around here. It's truly rich, but not greasy - as I have fine hair and it doesn't weigh it down or fast-forward an oily scalp. It's very moisturizing and I don't believe it contains any protein.
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ibrusat on 6/29/2010 7:33:00 AM more reviews by ibrusat
Age: 36-43 Skin: Dry, Fair Hair: Brunette Eyes: Hazel
Less than average product, not worth the price. It leaves hair soft and does not weight it down. I do not like the smell, not very pleasant - but bearable. I have chemically treated hair which are on the dry side (especially the ends). Whilst it does not make miracles (no salon effect), it does a decent job at keeping dry hair at bay. Far too expensive for what it delivers. Would not repurchase.
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*TOP REVIEWER* missykeyana on 5/22/2010 1:15:00 AM more reviews by missykeyana
Age: 25-29 Skin: Acne-prone, Dark, Neutral Hair: Black, Kinky, Medium Eyes: Brown
My stylist uses this on my hair when I get it trimmed and I liked the results. When I saw this on clearance at Kroger for about 6 dollars, I decided to try this at home as a deep conditioner. It works nicely. After shampooing and detangling, I applied a generous amount to my hair and let it sit for a few hours. When I rinsed it out, my hair was soft and moisturized. I wouldn't use it for detangling because there isn't enough slip, but it is good for deep moisturizing.
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bustedheadband on 4/3/2010 5:25:00 PM more reviews by bustedheadband
Age: 25-29 Skin: Combination, Fair-Medium Hair: Brunette Eyes: Hazel
Previous to this brand I was using Pantene because it was cheap, seemed to work and the best I had used thus far. However, my long semi-coarse thick hair ALWAYS felt really dry, brittle, and I had tons of split ends.
I asked a friend of mine with gorgeous hair what she used. She recommended this one even though it's too heavy for her fine hair. (She knows lots of people who do and love it.) So, I decided to not be cheap and just spend the extra money and try it.
I love it! I'm NEVER going back to drugstore/Pantene again! My hair is no longer dry or brittle and I haven't noticed any split ends. I think it smells great, too. Also, my boyfriend who never conditioned his hair because it made it "too greasy" loves this. This stuff is the best!
2 out of 2 people found this review helpful. Was this review helpful to you? Yes No
Top Rated Conditioner
- 30 reviews
ENJOY Luxury conditioner30 reviews
Trader Joe's Tea Tree Tingle Conditioner40 reviews
Aussie Cleanse and Mend Conditioner54 reviews


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Odisha BJP seeks white paper on cyclone Phailin
The Odisha unit of the Bharatiya Janata Party (BJP) Tuesday demanded a white paper on the damage caused by cyclone Phailin and subsequent floods in the state and the relief and restoration efforts carried out by the state government.
Senior BJP leader Manmohan Samal said here the state government was yet to provide compensation to all those affected by the calamities. He also alleged the government had not yet rebuilt the infrastructure in several places.
Accusing the government of not initiating any inquiry into the misappropriation of relief materials, reported at several places, Samal said: "The government must publish a white paper on all these matters".
"The government should tell the people, the amount of assistance it received from the centre and where the money was spent," he said.
Samal also accused the government of not taking measures to provide relief to the farmers, fishermen and others who suffered huge losses.
The very severe tropical cyclone Phailin in the Bay of Bengal made landfall Oct 12, 2013 night near the port town of Gopalpur in the state's Ganjam district.
At least 60 people were killed in the storm and subsequent floods. This was miniscule compared to the 1999 super cyclone that claimed 10,000 lives in the state.
(Posted on 21-01-2014)
Information on States of India:
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Andhra Pradesh Travel Map | Bihar Travel Map | Goa Travel Map | Gujarat Travel Map | Haryana Travel Map | Himachal Pradesh Map | Karnataka Travel Map | Kerala Travel Map | Maharashtra Travel Map | Punjab Travel Map | Rajasthan Travel Map | Sikkim Travel Map | Tamil Nadu Travel Map | Uttar Pradesh Travel Map | West Bengal Travel Map |
Alappuzha | Ernakulam | Idukki | Kannur | Kasaragod | Kollam | Kottayam | Kozhikode | Malappuram | Palakkad | Pathanamthitta | Thiruvananthapuram | Thrissur | Wayanad |
Airports of India | Districts of India | India Pilgrim Centers | Tourism Map of India | National Highways in India | India Railway Routes |
Ahmadabad | Bangalore | Chennai | Coimbatore | Delhi | Hyderabad/Secunderabad | Kochi | Kolkata | Mumbai | Pondicherry | Pune | Surat |


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Tags nostalgia, pop punk, throwback, 2000s, punk
Genres rock, pop punk, alternative, emo, indie (beta)
(flag as incorrect)
February 05, 2013
You know the words, I know you do // In celebration of Fall Out Boy coming off hiatus
im crying this is perf
a great throwback to a few years ago!
this playlist is seriously perfect
♡ best mix ♡
Great mix, brings back memories from past years but I love it! Oh, the nostalgia.
9th grade throwback.. never forget.
me too!!!
barely qualifies as music
terrible simply terrible
So don't listen to it or comment on it. Simple.
who am i, darling to you? by lsmyang
Songs for the one you want.
acoustic, indie, slow, sleep, love
lana with a twist by lsmyang
Acoustic versions and covers of Queen Lana's songs.
lana del rey, covers, indie pop, acoustic
once upon a time: the edge of glory by lsmyang
Part IV: For the momentously triumphant standing at the gold-crusted edge of glory.
instrumental, fantasy, soundtrack, epic, study
once upon a time: a lover's dance by lsmyang
Part III: For the blossoming love stories waiting for their tender flower to bloom.
instrumental, fantasy, soundtrack, study, writing


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Auret van Heerden: Making global labor fair
Labor activist Auret van Heerden talks about the next frontier of workers' rights — globalized industries where no single national body can keep workers safe and protected. How can we keep our global supply chains honest? Van Heerden makes the business case for fair labor.
Source: youtube.com
The NSA Video
More about the NSA than you ever wanted to know
#MSM - Obama Has Created An Illegal, Anti-Privacy Internet Program That Is Scarier Than #CISPA
Are you a "Critical Infrastructure Sector?" If so, then the Justice Department is giving you their stamp of approval to monitor private communications on your networks; an act which, according to the non-partisan Congressional Research Service, is a questionable legal use of an Executive Order. Through two recent Freedom of Information Act lawsuits, the Electronic Privacy Information Center (EPIC) recently revealed that the Justice Department has authorized internet providers — most prominently AT&T — to intercept and monitor communications on their networks. Its good news for these sectors: they get to freely violate existing federal wiretap laws. It's bad news for you and me, though. Through these acts we lose major privacy rights; namely not having our communications and private data tracked. Worse yet, it's due to a government-corporate partnership. Sounds bad? What is worse is that it ignores the actual cyber security issues we have, and it sets a terrifying precedent for the future.
The program in question began as an effort between the Defense Department, the Department of Homeland Security, and commercial defense contractors to protect military and commercial defense companies from cyber threats, in particular data theft. While the risk of cyber attacks on our military is a valid concern, it is clear now that this was not all that was on the architects of this project's mind.
Deputy Defense Secretary William J. Lyn said at the time of the program's inception: "It is possible to imagine attacks on military networks or on critical infrastructure like the transportation system and energy sector that cause severe economic damage, physical destruction or even loss of life."
No less than two years later, President Obama signed an Executive Order expanding this service to the same "critical infrastructure." The president's public renunciation of SOPA and CISPA is thus puzzling; those acts would accomplish many of the same goals and would be doing so legally. Obama's Executive Order, on the other hand, is not legal.
But what's most telling is that these safeguards are doing nothing to stop the underlying problem in the majority of these attacks: our global economic rival and current frenemy, China.
China accounted for 41% of the world's computer attack traffic in the fourth quarter of 2012 and it is heavily suspected that hundreds of attacks are actually coming from the Chinese militaryitself. Adding fuel to that fire, a Chinese general just claimed that these cyber attacks are potentially as powerful as a nuclear weapon. If they are able to attack this powerfully, are we simply waiting for an electronic 9/11 to hit us before our electronic privacy is taken away forever? This act certainly sets the precedent for removing our privacy with its vague notion of what "critical infrastructure" is, which could potentially be interpreted as broadly as the infamous "interstate commerce" has been. If it is, than "critical infrastructure" could mean almost anything; and all our electronic privacy could be washed away. Coming at a time when Americans are becoming more wary of government intrusions into their privacy, this act is an embarrassment to our country and a failure of our leadership.
Man Convicted of #Hacking Despite Not Hacking | #Anonymous #OpAngel
Culminating a two-week trial in which no hacking in the traditional sense occurred, a California man was convicted Wednesday under the same hacking statute internet sensation Aaron Swartz was accused of before he committed suicide in January.
Defendant David Nosal was convicted by a San Francisco federal jury on all six charges ranging from theft of trade secrets to hacking, despite him never breaking into a computer. Nosal remains free pending sentencing later this year, when he faces a potential lengthy prison term.
Nosal, a middle-aged man wearing a dark suit, sat stone faced as a clerk read "guilty" on all counts. Jurors deliberated for little more than two days.
After U.S. District Judge Edward Chen dismissed the 12-member jury, Nosal's defense team demanded a hearing to urge the judge to set aside the verdict. A hearing was set for later this year.
"We think, legally, these counts can't stand," Steven Gruel, a Nosal lawyer, said outside the courtroom. Prosecutors declined comment.
Nosal's prosecution was a novel application of the Computer Fraud and Abuse Act, the same statue Swartz was accused of violating when he allegedly breached security controls of an MIT database and downloaded millions of JSTOR academic articles. After Swartz's death, the case set off calls across the nation to reform the 1984 hacking law and perhaps even reduce the 5-year terms each violation carries.
But unlike Swartz, Nosal never was accused of traditional hacking. Among other things, what the jury concluded was that he coaxed, sometimes through monetary payments, his former colleagues at Los Angeles-based executive search firm Korn/Ferry International to access the firm's proprietary database and provide him with trade secrets to help him build a competing firm. Those associates cooperated with the government and were not charged.
The Computer Fraud and Abuse Act was passed in 1984 to enhance the government's ability to prosecute hackers who accessed computers to steal information or to disrupt or destroy computer functionality.
The act makes it a federal offense if one "knowingly and with intent to defraud, accesses a protected computer without authorization, or exceeds authorized access, and by means of such conduct furthers the intended fraud and obtains anything of value, unless the object of the fraud and the thing obtained consists only of the use of the computer and the value of such use is not more than $5,000 in any 1-year period." Prison penalties are up to 5 years per violation.
Nosal's case has had a lengthy history, with two trips to the San Francisco-based 9th U.S. Circuit Court of Appeals. A third trip is likely and perhaps the Supreme Court might weigh in to set boundaries around how far the government may go in prosecuting so-called hacking.
The 9th U.S. Circuit Court of Appeals, ruling in Nosal's case for a second time last year, decided that employees may not be prosecuted under the anti-hacking statute for simply violating their employer's computer use policy. The appeals court had tossed several charges against Nosal stemming from when he was a still a Korn/Ferry employee, in which he was accused of using his work credentials in 2005 to access his employer's database to help build a competing business for himself.
To be sure, the government indeed levies charges under the anti-hacking statute targeting traditional hackers. Two California men, for example, were sentenced between two and four years Monday in an extortion scheme stemming from the hacking of e-mail accounts of professional poker players.
But clearly, you don't have to be a hacker to be charged as one.
An online social media editor for the Reuters news agency, for example, was indicted last month for allegedly helping members of Anonymous hack another media organization's network.
Matthew Keys, the now-fired 26-year-old deputy social media editor for Reuters in New York, allegedly provided log-in credentials for a server owned by the Tribune Company, his former employer. He encouraged members of Anonymous to use the credentials to "go fuck some shit up," according to prosecutors.
The #Boston #bombing produces familiar and revealing reactions - #MSM
As usual, the limits of selective empathy, the rush to blame Muslims, and the exploitation of fear all instantly emerge
There's not much to say about Monday's Boston Marathon attack because there is virtually no known evidence regarding who did it or why. There are, however, several points to be made about some of the widespread reactions to this incident. Much of that reaction is all-too-familiar and quite revealing in important ways:
(1) The widespread compassion for yesterday's victims and the intense anger over the attacks was obviously authentic and thus good to witness. But it was really hard not to find oneself wishing that just a fraction of that compassion and anger be devoted to attacks that the US perpetrates rather than suffers. These are exactly the kinds of horrific, civilian-slaughtering attacks that the US has been bringing to countries in the Muslim world over and over and over again for the last decade, with very little attention paid. My Guardian colleague Gary Younge put this best on Twitter this morning:
Juan Cole this morning makes a similar point about violence elsewhere. Indeed, just yesterday in Iraq, at least 42 people were killed and more than 250 injured by a series of car bombs, the enduring result of the US invasion and destruction of that country. Somehow the deep compassion and anger felt in the US when it is attacked never translates to understanding the effects of our own aggression against others.
One particularly illustrative example I happened to see yesterday was a re-tweet from Washington Examiner columnist David Freddoso, proclaiming:
Idea of secondary bombs designed to kill the first responders is just sick. How does anyone become that evil?"
I don't disagree with that sentiment. But I'd bet a good amount of money that the person saying it - and the vast majority of other Americans - have no clue that targeting rescuers with "double-tap" attacks is precisely what the US now does with its drone program and other forms of militarism. If most Americans knew their government and military were doing this, would they react the same way as they did to yesterday's Boston attack: "Idea of secondary bombs designed to kill the first responders is just sick. How does anyone become that evil?" That's highly doubtful, and that's the point.
There's nothing wrong per se with paying more attention to tragedy and violence that happens relatively nearby and in familiar places. Whether wrong or not, it's probably human nature, or at least human instinct, to do that, and that happens all over the world. I'm not criticizing that. But one wishes that the empathy for victims and outrage over the ending of innocent human life that instantly arises when the US is targeted by this sort of violence would at least translate into similar concern when the US is perpetrating it, as it so often does (far, far more often than it is targeted by such violence).
Regardless of your views of justification and intent: whatever rage you're feeling toward the perpetrator of this Boston attack, that's the rage in sustained form that people across the world feel toward the US for killing innocent people in their countries. Whatever sadness you feel for yesterday's victims, the same level of sadness is warranted for the innocent people whose lives are ended by American bombs. However profound a loss you recognize the parents and family members of these victims to have suffered, that's the same loss experienced by victims of US violence. It's natural that it won't be felt as intensely when the victims are far away and mostly invisible, but applying these reactions to those acts of US aggression would go a long way toward better understanding what they are and the outcomes they generate.
(2) The rush, one might say the eagerness, to conclude that the attackers were Muslim was palpable and unseemly, even without any real evidence. The New York Post quickly claimed that the prime suspect was a Saudi national (while also inaccurately reporting that 12 people had been confirmed dead). The Post's insinuation of responsibility was also suggested on CNN by Former Bush Homeland Security Adviser Fran Townsend ("We know that there is one Saudi national who was wounded in the leg who is being spoken to"). Former Democratic Rep. Jane Harman went on CNN to grossly speculate that Muslim groups were behind the attack. Anti-Muslim bigots like Pam Geller predictably announced that this was "Jihad in America". Expressions of hatred for Muslims, and a desire to do violence, were then spewing forth all over Twitter (some particularly unscrupulous partisan Democrat types were identically suggesting with zero evidence that the attackers were right-wing extremists).
Obviously, it's possible that the perpetrator(s) will turn out to be Muslim, just like it's possible they will turn out to be extremist right-wing activists, or left-wing agitators, or Muslim-fearing Anders-Breivik types, or lone individuals driven by apolitical mental illness. But the rush to proclaim the guilty party to be Muslim is seen in particular over and over with such events. Recall that on the day of the 2011 Oslo massacre by a right-wing, Muslim-hating extremist, the New York Times spent virtually the entire day strongly suggesting in its headlines that an Islamic extremist group was responsible, a claim other major news outlets (including the BBC and Washington Post) then repeated as fact. The same thing happened with the 1995 Oklahoma City bombing, when most major US media outlets strongly suggested that the perpetrators were Muslims. As FAIR documented back then:
"In the wake of the explosion that destroyed the Murrah Federal Office Building, the media rushed — almost en masse — to the assumption that the bombing was the work of Muslim extremists. 'The betting here is on Middle East terrorists,' declared CBS News' Jim Stewart just hours after the blast (4/19/95). 'The fact that it was such a powerful bomb in Oklahoma City immediately drew investigators to consider deadly parallels that all have roots in the Middle East,' ABC's John McWethy proclaimed the same day.
"'It has every single earmark of the Islamic car-bombers of the Middle East,' wrote syndicated columnist Georgie Anne Geyer (Chicago Tribune, 4/21/95). 'Whatever we are doing to destroy Mideast terrorism, the chief terrorist threat against Americans, has not been working,' declared the New York Times' A.M. Rosenthal (4/21/95). The Geyer and Rosenthal columns were filed after the FBI released sketches of two suspects who looked more like Midwestern frat boys than mujahideen."
This lesson is never learned because, it seems, many people don't want to learn it. Even when it turns out not to have been Muslims who perpetrated the attack but rather right-wing, white Christians, the damage from this relentless and reflexive blame-pinning endures.
(3) One continually encountered yesterday expressions of dread and fear from Arabs and Muslims around the world that the attacker would be either or both. That's because they know that all members of their religious or ethnic group will be blamed, or worse, if that turns out to be the case. That's true even though leading Muslim-American groups such as CAIR harshly condemned the attack (as they always do) and urged support for the victims, including blood donations. One tweeter, referencing the earthquake that hit Iran this morning, satirized this collective mindset by writing: "Please don't be a Muslim plate tectonic activity."
As understandable as it is, that's just sad to witness. No other group reacts with that level of fear to these kinds of incidents, because no other group has similar cause to fear that they will all be hated or targeted for the acts of isolated, unrepresentative individuals. A similar dynamic has long prevailed in the domestic crime context: when the perpetrators of notorious crimes turned out to be African-American, the entire community usually paid a collective price. But the unique and well-grounded dread that hundreds of millions of law-abiding, peaceful Muslims and Arabs around the world have about the prospect that this attack in Boston was perpetrated by a Muslim highlights the climate of fear that has been created for and imposed on them over the last decade.
(4) The reaction to the Boston attack underscored, yet again, the utter meaninglessness of the word "terrorism". News outlets were seemingly scandalized that President Obama, in his initial remarks, did not use the words "terrorist attack" to describe the bombing. In response, the White House ran to the media to assure them that they considered it "terrorism". Fox News' Ed Henry quoted a "senior administration official" as saying this: "When multiple (explosive) devices go off that's an act of terrorism."
Is that what "terrorism" is? "When multiple (explosive) devices go off"? If so, that encompasses a great many things, including what the US does in the world on a very regular basis. Of course, the quest to know whether this was "terrorism" is really code for: "was this done by Muslims"? That's because, in US political discourse, "terrorism" has no real meaning other than: violence perpetrated by Muslims against the west. The reason there was such confusion and uncertainty about whether this was "terrorism" is because there is no clear and consistently applied definition of the term. At this point, it's little more than a term of emotionally manipulative propaganda. That's been proven over and over, and it was against yesterday.
(5) The history of these types of attacks over the last decade has been clear and consistent: they are exploited to obtain new government powers, increase state surveillance, and take away individual liberties. On NBC with Brian Williams last night, Tom Brokaw decreed that this will happen again and instructed us that we must meekly submit it to it:
"Everyone has to understand tonight that, beginning tomorrow morning early, there are going to be much tougher security considerations all across the country, and however exhausted we may be by that, we're going to have to learn to live with them, and get along and go forward, and not let them bring us to our knees. You'll remember last summer, how unhappy we were with the security at the Democratic and Republic conventions. Now I don't think we can raise those complaints after what happened in Boston."
Last night on Chris Hayes' MSNBC show, an FBI agent discussed the fact that the US government has the right to arrest terrorism suspects and not provide them with Miranda warnings before questioning them. After seeing numerous people express surprise at this claim on Twitter, I pointed out that this happened when the Obama administration exploited the attempted underwear bombing over Detroit to radically reduce Miranda rights over what they had been for decades. That's what the US government (aided by the sham "terrorism expert" industry) does in every single one of these cases: exploits the resulting fear to increase its own power and decrease everyone else's rights, including privacy.
At the Atlantic, security expert Bruce Schneier has a short but compelling article on how urgent it is that we not react to this Boston attack irrationally or with exaggerated fear, and that we particularly remain vigilant against government attempts to exploit fear to impose all new rights-reducing measures. He notes in particular how the more unusual an event is (such as this sort of attack on US soil), the more our brains naturally exaggerate its significance and frequency (John Cole makes a similar point).
In sum, even if the perpetrators of Monday's attack in Boston turn out to be politically motivated and subscribers to an anti-US ideology, it will still be a very rare event, one that poses far less danger to Americans than literally countless other threats. The most important lesson of the excesses arising from the 9/11 attacks should be this one: that the dangers of overreacting and succumbing to irrational fear are far, far greater than any other dangers posed by these type of events.
(via dystopiance)
Source: descentintotyranny
When a Robot Signs a Bill: A Brief History of the Autopen - #WTF
While serving as the 3rd president of the United States, Thomas Jefferson discovered a piece of technology that he could simply not live without. And no, it wasn't this thoroughly gonzo precursor to the home gym.
It was the polygraph (shown on the right): a machine that made direct copies of handwritten letters. The user would write a version on one side of the machine, and by mechanical action, the words would be instantly facsimiled on the other. Being the technophile that he was, Thomas Jefferson purchased two: one for the White House, one for Monticello.
In 1809, he wrote to the portrait artist Charles Wilson Peale raving that "the use of the polygraph has spoiled me for the old copying press the copies of which are hardly ever legible… . I could not, now therefore, live without the Polygraph."
As it turns out, neither can modern-day presidents.
Yesterday, the president was in Hawaii, rejoining his family on vacation. The recently passed fiscal-cliff deal was in Washington. How could the all important-presidential signature be affixed to the bill to make it law? The solution: Obama signed it via a robot, the autopen, a technological great, great grandchild of the machine Jefferson so loved.
Although the White House won't tell you how it works, the device essentially makes a copy of the president's pen strokes and saves them in the system's memory for future facsimile. Typically, any pen or pencil can be loaded into the machine. It has been reported that George W. Bush prefered Sharpies.
Citing ambiguity in the Constitution (the exact line is "if he approve he shall sign it"), George W. Bush's Justice Department made the legal case that an autopen is as good as the president's hand when it comes to signing bills.
"Neither the constitutional text nor the drafting and ratification debates provide further guidance regarding what it means for the President to 'sign' a bill he approves," the opinion begins, and then dives into a lengthy legal discussion of what "signing" meant during the early days of the republic (it's a thrilling read with many footnotes).
Although Bush set up the legal argument for autopen bill signing, he never used the device to enact legislation. Obama was the first to do so, signing an extension of the PATRIOT Act via autopen while in Europe. (Kind of fitting that a robot re-signed into law an act that represents the tenuous nature of technology, privacy, and the role of government.) Some lawmakers objected to the move, but no serious legal challenge to auto-signing bills has ever surfaced.
While Jefferson's polygraph could only make copies if he was writing an orignial, fully robotized auto pens didn't arrive until the 1930s. A 1936 article in Popular Mechanics described how the machine recorded a signature on "a master record, comparable to a phonograph,"and was transcribed by a "secret process" to make it difficult to steal one's signature. There was even a function to scramble the recording, rendering the machine useless for a would-be signature thief. (Modern machines store signatures on SD cards.) Harry Truman is said to be the first U.S. president to use such a robotized machine.
The White House treats the presidential autopen's security with the secrecy you might expect for the most powerful signature in the world. "I always heard the autopen was the second-most guarded thing in the White House after the president," Jack Shock, Bill Clinton's director of presidential letters and messages told the Associated Press in 2011. When the AP pressed the matter to the executive branch, the White House "declined to provide any further details about how many autopens the administration uses, what they look like, where they're kept, or who makes the machine."
While there was no signing ceremony for the fiscal cliff legislation, here's how it probably happened.
Eighteen Federal Legislators Ask Uncle Sam To Leave Marijuana Legalization Alone
(420Times) Eighteen federal legislators are supporting a call for The Obama Administrationto lay off recently passed marijuana legalization measures in Colorado and Washington. Colorado Congressman Diana DeGette plans on introducing a bill that would mirror a letter that her and 17 of her colleagues signed, asking the Justice Department to respect state's rights.
"We are writing to urge federal law enforcement to consider carefully the recent decisions by the people of Colorado and Washington to legalize small amounts of marijuana for personal use by adults," the letter reads in part. "Under the new laws, each state will establish a comprehensive regulatory scheme governing the production, sale and personal use of marijuana. We believe that it would be a mistake for the federal government to focus enforcement action on individuals whose actions are in compliance with state law."
#2012 #Nobel #PeacePrize awarded to #EU - "for over six decades contributing to the advancement of peace…"
(via culturerevo)
Source: anontwo
IDF: @Intel says Clover Trail will not work with #Linux
SAN FRANCISCO: CHIPMAKER Intel has confirmed that it will not provide support for Linux on its Clover Trail Atom chip.
Intel's Clover Trail Atom processor can be seen in various nondescript laptops around IDF and the firm provided a lot of architectural details on the chip, confirming details such as dual-core and a number of power states. However Intel said Clover Trail "is a Windows 8 chip" and that "the chip cannot run Linux".
As Intel is pushing Clover Trail into tablets, a category of devices that is dominated by Linux based Android and the Unix BSD based IOS, the firm said it will not support Linux on Clover Trail.
Given that Intel said Clover Trail takes a lot of technology from its Medfield Atom processor, which runs Android on a number of middling smartphones, it seems that Chipzilla is putting up an artificial barrier to try to help Microsoft and its upcoming Windows 8 operating system.
While Intel's claim that Clover Trail won't run Linux is not quite true - after all it is an x86 instruction set so there is no major reason why the Linux kernel and userland will not run - given that the firm will not support it, device makers are unlikely to produce Linux Clover Trail devices for their own support reasons.
Intel didn't detail why it won't support Linux on Clover Trail processors and instead merely mumbled murkily that "there's a lot of software work that has to go into a chip to support it in an operating system".
Intel went to great lengths to highlight the new P-states and C-states in which it can completely shut down the clock of a core. The firm said the operating system needs to provide "hints" to the processor in order to make use of power states and it seems likely that such hints are presently not provided by the Linux kernel in order to properly make use of Clover Trail.
Intel's decision to support only Windows 8 on Clover Trail might work for laptops but seems very risky for tablets, where x86 tablets running Windows 8 look to be priced close to Apple's Ipad and significantly higher than Google's Nexus 7 and Amazon's Kindle Fire HD.
When the PC market speaks, Intel and Microsoft might well find that Clover Trail is a dead end. µ
AMD's Hondo will only support #Windows8 at launch, not #linux
SAN FRANCISCO: CHIP DESIGNER AMD said its upcoming Hondo processor will be featured only on Windows 8 tablets at launch.
AMD's Hondo APU is the firm's first serious attempt to get into the tablet market and as the firm was busy showing hacks that Hondo can be used in devices that are sleek, it also told The INQUIRER that the firm is focusing on Windows 8. However unlike Intel, AMD said there is nothing stopping people from running Linux on its Hondo processor.
Steve Belt, corporate VP of ultra low power products at AMD told The INQUIRER, "This is a Windows 8 product, only. We're not doing Android on this platform, at least not now. […] It is a conxcious decision not to go after Android. We think the Windows 8 space has a lot of opportunity, there's plenty of TAM [total addressable market] there for us to go at. So we don't need to spread ourselves into other markets, we think Windows 8 is a great place to start. Down the road we may look at Android, right now we're focused on Windows 8."
AMD is banking on Microsoft's Windows 8 tablets to take up somewhere between 15 and 20 percent of the market, and to be fair if AMD can achieve a mid-teens market share in that portion, it will have done well, given its late entry and being hamstrung by Microsoft's operating system. However unlike Intel, Belt said AMD's software engineers are working on Linux support, though that doesn't necessarily mean Android.
Ultimately Intel's decision not to support Linux on Clover Trail could be costly, and not just in the tablet market. AMD's Hondo Linux support could come in handy in the low-power server market that Intel is trying to edge into. With AMD's Hondo GPU the firm could try to differentiate itself from Intel, which has only recently enabled OpenCL support on its integrated graphics cores.
With both AMD and Intel readying Hondo and Clover Trail respectively for Windows 8 and pushing their respective customers to come up with designs at roughly the same time, it will be interesting to see just how many Windows RT tablets will appear at the operating system's launch. However one thing is clear, neither AMD nor Intel will have Android x86 tablets running with their respective next generation ultra low voltage chips. µ
Wal-Mart Takes Over America of the Day: And here we have unimpeachable proof that America's exponential decay began in 1962.
Let's just say that if this was happening on my bread, I'd throw it out.
(via vortexanomaly)
Source: thedailywhat
No More Skipping Your Medicine – FDA Approves First Digital Pill
The Food and Drug Administration has just approved a device that is integrated into pills and let's doctors know when patients take their medicine – and when they don't. Adherence to prescriptions is a serious problem, as about half of all patients don't take medications the way they're supposed to. But with patients doctors now becoming big brother, that statistic could change drastically.
The device, made by Proteus Digital Health, is a silicon chip about the size of a sand particle. With no battery and no sensor, it is powered by the body itself. The chip contains small amounts of copper and magnesium. After being ingested the chip will interact with digestive juices to produce a voltage that can be read from the surface of the skin through a detector patch, which then sends a signal via mobile phone to inform the doctor that the pill has been taken. Sensors on the chip also detect heart rate and can estimate the patient's amount of physical activity. More than just a way for doctors to look over their patients' shoulders, it will allow doctors to better assess if a person is responding to a given dose, or if that dose needs to be adjusted.
After clinical trials that began in 2009, the FDA approval follows approval from European regulatory approval in August 2010. Right now the FDA has only approved the chip for placebo pills, which were used in trials showing the chip to be safe and highly accurate. Proteus hopes to gain approval to use the digestible chip with other medicines. Andrew Thompson, chief executive of Proteus, says the chip has already been tested with treatments for tuberculosis, mental health, heart failure, hypertension, and diabetes.
The company is currently working with makers of metformin, a drug used to treat type 2 diabetes and the most commonly prescribed drug in the world. The company also plans on adding a wireless glucose meter to their device so that dosage amount and frequency can be correlated with changes in blood glucose levels.
They would also like to digitize the drugs taken to treat neurological disorders. Disorders such as Parkinson's Disease and Huntington's Disease often require patients to receive drugs regularly – sometimes several times per day – and for extended periods of time. Ensuring that these patients are adhering to the prescribed regimen could greatly improve quality of life for some.
Transplant patients, who often have to take immunosuppressive drugs for long periods following surgery, could also potentially benefit from digitizing their medicine.
Ingestible body sensors have been discussed for a while now, but Proteus' digital pills are the first ingestible sensor to be approved by the FDA, according to Nature. This first step toward regulated ingestible sensors will undoubtedly be followed by others. The Programmable Bio-Nano-Chip developed by Rice University scientists can detect heart disease or cancer from a saliva sample. If the chips were ever permanently implanted into the body, they could provide an early alarm system for these diseases long before symptoms are detected by the patient. Scientists at Tel Aviv University in Israel and Brigham & Women's Hospital in Boston are developing a pill-sized robot that is remotely powered by an MRI machine to swim through the gut and look for the molecular signs of gastrointestinal cancer.
The first demonstration involved a placebo, but surely drug companies are eager to digitize their pills – and make sure patients empty out their prescriptions when they're supposed to. Although possible, it is hard to imagine a complication would arise when the device is used with, say, Lipitor, that did not arise with the placebo. The usual FDA bottleneck could be loosened with the first incorporation into a bonafide drug.
The possible uses for ingestible sensors is as varied as the body itself. As with computer chips, ingestible chips will follow the exponential path of Moore's Law and be able to sense more with less in the future. The FDA ruling could do much to get the technology on the fast track.
#Aspartame Renamed #AminoSweet and is Now Being Marketed as a Natural Sweetener - #WTF
Artificial sweeteners especially aspartame has gotten a bad rap over the years, most likely due to studies showing they cause cancer. But not to worry Ajinomoto the company that makes
Aspartame has changed the name to AminoSweet. It has the same toxic ingredients but a nice new sounding name. And if you or your child happens to be allergic to Aspartame, well don't take it personally it's just business.
Despite the evidence gained over the years showing that aspartame is a dangerous toxin, it has remained on the global market . In continues to gain approval for use in new types of food despite evidence showing that it causes neurological brain damage, cancerous tumors, and endocrine disruption, among other things.
Most consumers are oblivious to the fact that Aspartame was invented as a drug but upon discovery of its' sweet taste was magically transformed from a drug to a food additive. HFA wants to warn our readers to beware of a wolf dressed up in sheep's clothing or in this case Aspartame dressed up as Aminosweet.
Over 25 years ago, aspartame was first introduced into the European food supply. Today, it is an everyday component of most diet beverages, sugar-free desserts, and chewing gums in countries worldwide. But the tides have been turning as the general public is waking up to the truth about artificial sweeteners like aspartame and the harm they cause to health. The latest aspartame marketing scheme is a desperate effort to indoctrinate the public into accepting the chemical sweetener as natural and safe, despite evidence to the contrary.
Aspartame was an accidental discovery by James Schlatter, a chemist who had been trying to produce an anti-ulcer pharmaceutical drug for G.D. Searle & Company back in 1965. Upon mixing aspartic acid and phenylalanine, two naturally-occurring amino acids, he discovered that the new compound had a sweet taste. The company merely changed its FDA approval application from drug to food additive and, voila, aspartame was born.
G.D. Searle & Company first patented aspartame in 1970. An internal memo released in the same year urged company executives to work on getting the FDA into the "habit of saying yes" and of encouraging a "subconscious spirit of participation" in getting the chemical approved.
G.D. Searle & Company submitted its first petition to the FDA in 1973 and fought for years to gain FDA approval, submitting its own safety studies that many believed were inadequate and deceptive. Despite numerous objections, including one from its own scientists, the company was able to convince the FDA to approve aspartame for commercial use in a few products in 1974, igniting a blaze of controversy.
In 1976, then FDA Commissioner Alexander Schmidt wrote a letter to Sen. Ted Kennedy expressing concern over the "questionable integrity of the basic safety data submitted for aspartame safety". FDA Chief Counsel Richard Merrill believed that a grand jury should investigate G.D. Searle & Company for lying about the safety of aspartame in its reports and for concealing evidence proving the chemical is unsafe for consumption.
The details of aspartame's history are lengthy, but the point remains that the carcinogen was illegitimately approved as a food additive through heavy-handed prodding by a powerful corporation with its own interests in mind. Practically all drugs and food additives are approved by the FDA not because science shows they are safe but because companies essentially lobby the FDA with monetary payoffs and complete the agency's multi-million dollar approval process.
Changing aspartame's name to something that is "appealing and memorable", in Ajinomoto's own words, may hoodwink some but hopefully most will reject this clever marketing tactic as nothing more than a desperate attempt to preserve the company's multi-billion dollar cash cow. Do not be deceived.
Update: As many comments are being posted by readers who are allergic to Aspartame we ask that you please forward this article to as many people as you can.
#Google 's Opaque New Policy Lets Rights-holders Dictate Search Results #copyWRONG
Earlier this summer, we applauded Google for releasing detailed stats about content removal requests from copyright holders. Now that we know how they are going to use that data, we are less enthusiastic. Today, Google announced that it would use copyright takedown notices made under the DMCA1 as what it calls a "signal" on search results. Specifically, those "signals" will demote certain websites in search results.
We wish we had some more details to illustrate just what that means, but unfortunately the process is pretty opaque. What we know: sites that have a "high number of removal notices" of takedown notices that result in actual takedowns will show up lower in some search results, though they will not be removed. What we don't know: what is a "high number"? How does Google plan to make these determinations? Oh, and one other thing we do know, one that is particularly troubling: there will be no process or recourse for sites who have been demoted.
In particular, we worry about the false positives problem. For example, we've seen the government wrongly target sites that actually have a right to post the allegedly infringing material in question. or otherwise legally display content. In short, without details on how Google's process works, we have no reason to believe they won't make similar, over-inclusive mistakes, dropping lawful, relevant speech lower in its search results without recourse for the speakers.
Takedown requests are nothing more than accusations of copyright infringement. No court or other umpire confirms that the accusations are valid (although copyright owners can be liable for bad-faith accusations). Demoting search results – effectively telling the searcher that these are not the websites you're looking for – based on accusations alone gives copyright owners one more bit of control over what we see, hear, and read.
Of course, Google is not seizing domain names, as the government does. And it's not removing sites from its search results altogether at copyright owners' request, as SOPA would have required. To its credit, Google says that it will respect counter-notices, and won't demote results based on takedowns that are rightfully disputed. But this is little comfort. Google's opaque policies not only threaten lawful sites, but they undermine our confidence in its search results.
- 1. The Digital Millennium Copyright Act shields websites against most copyright suits based on material posted by their users, provided that the site takes certain actions, including taking down content when a copyright holder sends a valid request.


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Home » News » Education
Manchester Central students ready for makeovers, a night at opera
It will be the first time any of the high school seniors have been to an opera, even if it is a live broadcast on a movie screen. The showing will culminate a day of makeovers courtesy of cosmetology students from the Manchester School of Technology, including manicures and nail painting for the girls, and dinner at the Great Buffet.
The daylong event is the brainstorm of Roy Shoults, Ward 4 school board member, who is determined that the cultural trip will be expense-free for both students and the school district. He said Superintendent Thomas J. Brennan is personally covering the cost of bus transportation. Ted Herbert's Music and Art Center contributed toward the cost of the tickets.
Tracey Crain and Aidan Connell, both from Hooksett and seniors in the advanced placement English class taught by Selma Naccach-Hoff, said they are grateful and excited for the opportunity. Crain plays the French horn and hopes to one day be an elementary school teacher, after earning a master's degree in music education, but also perform in symphony orchestras.
"It's a great opportunity," she said of attending the opera broadcast in high-definition at the Capital Center for the Arts in Concord.
Connell said he gets to see a lot of plays and musical productions because he is an actor involved in community musical theater, but he relishes the opportunity to see every aspect of musical performance, especially an opera.
The Francesca da Rimini opera was selected for the field trip because the students studied Dante's Inferno, which is about people who committed sins serving out their punishment in hell.
Shoults said the cost of taking students to a live opera performance is prohibitive. A front-and-center seat at the 3,900-seat Metropolitan Opera House at the Lincoln Center for the Performing Arts in Manhattan can cost $450, although $20 will buy a nose-bleed seat. Then, of course, there would be the added cost of getting there.
The students will be sitting in a 1,304-seat theater about 250 miles away where they will watch and listen as the opera stars take center stage in Manhattan.
"The Met is the best by far," said Naccach-Hoff.
Crain is looking forward to the entire day, especially the pre-opera primping, and has a dress already picked out. "I love to dress up," she said.
Connell is not as enthused about the makeover, which for the guys entails being clean-shaven and properly groomed.
Still, he's pulling out his suit jacket and tie.
"I think all the girls are going to look awesome so I have to try to match that," he laughed.
Donations for the outing may be sent directly to the Manchester Finance Department (Tax ID #02-04-94977), Manchester School Department, 195 McGregor St., Manchester, 03102.
Shoults said he doubts there will be any surplus, but if there is, it will go to future projects. He's looking into a plan to hold a battle of the jazz bands for the city's three high schools.
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I've been afraid of playing the actual Fire Emblem games, because I heard they have the concept of "permanent death" in them.
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I've been afraid of playing the actual Fire Emblem games, because I heard they have the concept of "permanent death" in them.
It's kinda like chess but fighting and luck are included, it's one of the best games ever.
You poor, deprived fool.
I had to restart the whole misiion so many times…
Oh yeah! I make sure that none of my characters die, and I even go so far to make sure that I get my characters to level...
I reblogged it to show my friend nikki xD I'd LOVEEEEEEEEEEEEe to play them :D
Oh, but they do. :] That's why none of my characters die. But honestly, it's an amazing series. Try it out anyways!
Man, the Fire Emblem games are amazing, but the permanent death thing is extremely annoying. I think this series has...
There's no need to be afraid! Just reset if a character dies. That's how the vast majority of the fans play, anyway. The...
Makes them that much more challenging. You could always start the mission all over again if you really don't want to...


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Radio Times Audience Award Winner: Game of Thrones
Find out more about this Award on BAFTA.org.
Welcome to the BAFTA Television Tumblr, a gateway into the wonderful world of television.
We'll be bringing you all the latest BAFTA Television news, photos and videos straight to your Tumblr dashboard.
Find out more at www.BAFTA.org/television