text:
(PreK-4) | 1290 Arcade St. | (651) 293-8675
(5-8) | 1000 Walsh St. | (651) 293-8880
Our program engages a child's imagination. We learn to dream big, and become leaders. Our focus encompasses a wide range of disciplines. From engineering aircraft to designing spacesuits, we solve problems using creativity and teamwork. We develop confidence — so when we do fly — we reach for the stars.
Farnsworth is a magical place. Every child is challenged to reach for the stars. Our families, staff, and community embrace our aerospace theme and use it to inspire our young students to learn about our world. Every day is a new adventure!
-- Laura Saatzer
PreK - 4 Campus
1290 Arcade Street
St. Paul, MN 55106
Office: (651) 293-8675
Attendance Line: (651) 744-4313
School Hours: 9:35 a.m. - 4:05 p.m.
Farnsworth will always be a place where students and their families join our staff to learn new things together. Our extended field experiences and guest experts are more than a tradition, they are the key to our progress in an ever changing field.
—Hamilton Bell
5 - 8 Grade Campus
1000 Walsh Street
St. Paul, MN 55106
(651) 293-8880
Attendance Line: (651) 744-4403
School Hours: 9:30 a.m. - 4 p.m.
School Spirit Week will happen for the lower campus (PreK-4) this week, October 27-30th. Below are the suggested agenda.
Join us for an evening of learning & support through Family-School partnerships and shared community resources. Click for more details.
We are implementing a new bus schedule for ONLY the afternoon dismissal starting Monday, October 20th.
With the recent concerns about the Ebola virus, the Saint Paul Public School District is following the guidance of the experts at the Minnesota Department of Health.
■ See the Details
SPPS is engaging stakeholders—teachers, students, principals, community programs and more—in order to determine whether the district should change start times for primary and secondary schools.
2014-15 PreK-4 School Supply List
Saint Paul Public Schools is Minnesota's largest school district.
■ About SPPS
■ For Parents
■ News tips
■ IT support
■ Contact Us
Click for info
Laura Saatzer, Principal| (PreK-4) 1290 Arcade St., Saint Paul, MN 55106| (651) 293-8675
Hamilton Bell, Principal| (5-8) 1000 Walsh St., Saint Paul, MN 55106 | (651) 293-8675


text:
A visit to Al-Buss and Saida
A few weeks ago, I had the opportunity to conduct an interview with the Loan Project Coordinator of Najdeh, Ms. Yosra Jrad, in Al-Buss camp, located in Tyre (otherwise known as Ṣūr to the Lebanese). I had lost my translator last minute, as her bus broke down on the way to meet me at work, and had to manage with an English teacher from the camp. When I later went over the translated transcripts, the looks of confusion from Ms. Jrad during our interview suddenly made sense. It was clear that the English teacher did not really understand what I was asking and simply improvised all of the questions, leaving me with a very nonsensical transcript.
Luckily all was not lost, as the teacher, along with another Najdeh employee offered to give me a tour of the camp. I was expecting dire conditions, lack of space, wires hanging everywhere, much like my experiences in other camps. However, it was quite the contrary. In fact, Al-Buss camp is one of the cleanest, most spacious camps in Lebanon. Streets are wide, refugees have actual homes with gardens and backyards, there are trees and other greenery and the schools offer children actual places to play and have fun with jungle gyms and toys.
Despite the neighborhood-like aesthetic, there is still much improvement to be made. There are many who suffer from the heat of the summer and cold of the winters, with metal roofs and lack of insulation in homes. The only UNRWA school directly faces a garbage dump in the camp. Initially, there had been some disagreements on whether or not the waste could be removed from the camp at all. There is one hospital, however the majority of Palestinians do not carry insurance and must pay out of pocket for surgeries and other expensive treatments. To manage, patients will beg the community and neighbors to donate to their cause.
This was the first camp I went to that had checkpoints at the entry and exit. You must carry an ID or permit to enter and exit the camp. More than half the refugees find it very difficult to leave, as they are not documented. I was not aware of this before my departure and learned it would take up to several days to obtain a permit. The driver assured me not worry and said I could pass as Lebanese. We were able to enter, no questions asked. However, my new Najdeh friends expressed concern on my exiting the camp, as the checkpoints are very strict. They devised a plan to avoid the checkpoint. The driver drove out of the camp without me, while the teacher escorted me out over piles of rocks and rubble (from a fallen shop) to the main street. There, I was reunited with the driver.
Above: Where I was able to exit the camp.
A few days after the Al-Buss interview, I was sent to Saida (a bit north of Tyre) to interview some students at a vocational center. Upon my return home, I learned that a UNFIL convoy had been bombed along the coastal road, a mere few hours after my departure on the same road. It was a strong reminder that there are still many dangers in Lebanon, the effects of the civil wars linger, and the anti-West sentiment remains strong.

subset: commoncrawl


text:
Advertise Here
Advertise Here
Information for Homestead, FL
Info about Coral Gables, Homestead, Cutler Ridge, and Homestead, FL (Florida). Homes, weather, photos, schools, and more. ZIP 33001 Airport mia Homes starting at $50,000.
Homestead, FL
Homes - Schools - Census Data - Jobs - Maps
Latitude: 25.47119 -- Longitude: -80.468122Homestead, Florida Public and Private Schools and Homestead, Florida Universities and Colleges
Homestead, Florida Jobs
Homestead, Florida RePages
Homestead, Florida Classifieds
Homestead, Florida Airports
Homestead, Florida Hospitals
Homestead, Florida Business Directory
We need more photos. If you have photos of your local area, submit them today. Click here to Add Photos.
To have your business displayed on this page, visit www.Infignos.com
Premium Listings only will appearat the top of this page.
Homestead is a city in Miami-Dade County, Florida, United States nestled between Biscayne National Park to the east and Everglades National Park to the west. Homestead was incorporated in 1913. It is located approximately 35 miles southwest of the city of Miami, and 25 miles northeast of Key Largo. It gets its name from a path that was the only way to reach the area - the "Homesteaders' Trail". As of the 2000 census the city population was 31,909. As of 2004, the population recorded by the U.S. Census Bureau was 37,957 [1]. The city of Homestead is located near the southern terminus of the Homestead Extension of Florida's Turnpike where it ends at its junction with U.S. 1. Homestead is immediately north of Florida City, and these two cities comprise the greater Homestead-Florida City area. Some of the notable unincorporated communities in the area are Redland, Leisure City, Naranja, and Princeton. -- Source: Wikipedia.com
Get your Free Homestead Home Buyer Relocation Packet today.
What to do in NewQuestCity.comTM: Learn about Homestead. See Homestead photos. Join our Discussion Forums.
Enter our Photo Sweepstakes and Win $200 for your Homestead photos!
To see random photos for other cities Click Here.
Submit your photos of Homestead and become eligible to win $200. Click Here for details.
We need more photos. If you have photos of your local area, submit them today. Click here to Add Photos.
Top News Stories
|United States
|Median age
|Median age for Male
|Median age for Female
|Household population
|Average household size
|Average family size
|Housing units
|Occupied units
|Vacant units
Other Area Cities: Coral Gables Homestead Cutler Ridge Goulds East Perrine Richmond Heights Leisure City
Other Popular Florida Cities: Arcadia Beverly Hills Boca Raton Bradenton Brandon Brooksville Cape Coral Clearwater Clermont Cocoa Beach Coral Springs Crestview Crystal River Daytona Beach Deerfield Beach Deltona Destin Dunedin Englewood Fort Lauderdale Fort Myers Fort Myers Beach Fort Pierce Fort Walton Beach Gainesville Inverness Jacksonville Jupiter Kendall Kissimmee Lady Lake Lake Worth Lakeland Land O' Lakes Largo Leesburg Lehigh Acres Lynn Haven Marianna Melbourne Merritt Island Milton Miramar Mount Dora Naples New Port Richey New Smyrna Beach North Fort Myers North Port Orlando Oviedo Palatka Palm Bay Palm Beach Gardens Palm Coast Palm Harbor Panama City Pembroke Pines Pensacola Plant City Port Charlotte Port Orange Port Richey Port St Lucie Punta Gorda Ruskin Saint Petersburg Sarasota Sebring Spring Hill St Augustine Stuart Sun City Tampa Tarpon Springs Titusville Venice Vero Beach Wellington West Palm Beach Winter Haven Zephyr Hills
If you are planning a relocation to Homestead Florida and are interested in existing homes in Homestead Florida or new homes in Homestead Florida, let BuyersUSA Relocation provide you with homes and housing information. If you are relocating to Homestead you can receive a FREE Relocation to Homestead Florida relocation package, which may include a map of Homestead, a Homestead newspaper, information about homes in Homestead Florida and more. This is an ideal, worry free way to ease the stress of relocation to Homestead Florida by giving you a Homestead Relocation expert to help coordinate your move to Homestead Florida. We want to help you make your search for Homestead Florida Real Estate as easy and as pleasant as possible. Real Estate in Homestead Florida is probably very different from your current location trust your Homestead Florida Relocation to an expert!
Topics on this site include: Homestead homes, Homestead new homes, Homestead real estate and Homestead newspaper including homes Homestead real estate, Homestead FL real estate and check Homestead MLS homes for sale and houses for sale, find realtors and real estate agents, get new houses plus Homestead new homes and homebuilders, find Homestead foreclosures, Homestead houses for sale, condominiums and Homestead Condos, and Homestead FL newspaper reports, lofts and Homestead lofts homes, look for apartments townhomes townhouses, search jobs and help wanted, movies, bars, restaurants and events, Homestead luxury homes.
|Residential and Commercial Garden & Landscaping
|Residential and Commercial Garden Landscaping Services & lawncare Miami, Homestead, Kendal. Plant and Palm Tree Nursery. Fort Lauderdale
|Coldwell Banker Real Estate
|Great condo in the Gables area. Spacious 776 sq.ft 1 bed/1 bath, washer/dryer in unit. Walk in closet in master bedroom.Ammenities include pool,& gym. Walking distance to great shops Miracle Mile & Restaurants. Wo'nt Last, Easy to show. Great Investment Opportunity! Call listing agent Mayda Barker 305 772-1950 or e-mail for more info firstname.lastname@example.com Coral Gables
|Miami Photographer
|Miami Photographer specializing in children, family and event photography. North Lauderdale
|Atlantis Realty Group Inc.
|Looking for a Home or an Investment property? We helps buyers and sellers find the perfect property for the Miami and Florida Keys areas. We specialize in REO properties and will give you the same great service reguardless of price. West Palm Beach
|Excede Services, Inc
|Our preference for quality over quantity drives us to use our utmost potential as we treat each project as our first. The portfolio of Excede Services, Inc. contains projects par excellence in the field of web development. The web applications that. Alaska
|CrossFit Boynton Beach
|CrossFit, by definition is: 'Constantly varied, functional movements, executed at high intensity'. It is the ultimate fitness program. CrossFit builds a sense of community. Alaska
|James J. McCall, DDS, PA
|Serving Jacksonville, Ponte Vedra, and St. Augustine, FL - Dr. James McCall is your general and cosmetic dentist, offering Invisalign®, veneers, and dental care for children, teens, and adults. Alaska
|Superior Speaker Repair & Service
|Professional speaker and amplifier repair sales and service Fast and reliable service with a friendly and knowledgeable Staff. Serving the Orlando area for a combined total of over 40 years. Alaska
|Personal Mini Storage
|Personal Mini Storage- Self Storage (across from the Skylark Plaza) has a special on all units no matter what the size!!! We have the right size for you! Alaska
|Personal Mini Storage- Self Storage
|Self Storage Leader & truck rental center! Personal Mini Storage- Self Storage (across from the Skylark Plaza) has a special on all units no matter what size is rented!! Alaska
|Modular Kitchen Chennai
|We Provide modular kitchen, kitchen cabinet, kitchen accessories and appliance in chennai and other part of southindia. We provide customer with unique design and model Alaska
|ACE Heating & Cooling
|ACE Heating & Cooling is locally owned (Brandon FL) and operated full service residential and commercial heating and cooling company. We send technicians not salespeople to build long lasting relationships with our customers. Call ACE (813)657-8818. Alaska
|West Palm Beach Psychic
|Psychic Clairvoyance sessions by Mrs. David. Specializing in:Love,Health,Career and Direction Alaska
|Atlantic Animal Hospital
|IS your pet hurt or sick? We are availible for emergencies at any time, day or night. Call us for immediate help. A licensed Florida Veterinarian will answer the phone. Alaska
Weather Forecasts | Weather Maps | Weather Radar
|If you have been negatively impacted by the Great Depression of the 21st Century
This is your survival and recovery guide.
Get yours today!


text:
Ugh I know when I'm older and living with a boyfriend, whereever that may be, I'm going to be the type of girlfriend who is always in underwear and a baggy band tank top. I'm going to dance everywhere, and leave stupid silly notes in the fridge and on the counter and on the pillows and in his sock drawer. I'm going to pop randomly into the room when he's doing really important work and just belt out a lyric in some horribly untuned voice and then run away. I'm going to lay on the floor all the time, just because and I'll probably sit in the laundry basket full of clothes and demand to be carted around the house to the laundry room. I'm going to make breakfast always, and make tea even when its really hot outside. There will ALWAYS always always be a stash of cookies somewhere and he'll have to eat them even if they're horrible and burnt like they usually are. I want us to buy lots of artistic prints and redecorate the house approximately every month or so because we'll forever be unsatisfied with our clashing tastes and the routine we fall into. I want bubble baths and movie nights, maybe both together, or maybe where we're just sprawled out on a bed in nothing but socks. Its just how its going to be, there's no way this won't be my future life.
(Source: lykanthropic)


text:
Quotes & Info
|CRIS > SEC Filings for CRIS > Form 10-Q on 12-Nov-2013
|All Recent SEC Filings
Quarterly Report
The following discussion of our financial condition and results of operations should be read in conjunction with the condensed consolidated financial statements and the related notes appearing elsewhere in this report. Some of the information contained in this discussion and analysis and set forth elsewhere in this report, including information with respect to our plans and strategy for our business, includes forward-looking statements that involve risks and uncertainties. You should review the section titled "Risk Factors" in Part II, Item 1A of this report for a discussion of important factors that could cause actual results to differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis. As used throughout this report, the terms "the Company," "we," "us," and "our" refer to the business of Curis, Inc. and its wholly owned subsidiaries, except where the context otherwise requires, and the term "Curis" refers to Curis, Inc.
We are an oncology-focused drug development company seeking to develop novel, targeted drug candidates for the treatment of human cancers. We conduct our research and development programs both internally and through strategic collaborations. Erivedge® is the first and only approved medicine for the treatment of advanced basal cell carcinoma, or BCC, and is being commercialized by F. Hoffmann-La Roche Ltd, or Roche, and Genentech Inc., or Genentech, a member of the Roche Group, under a collaboration agreement between Curis and Genentech. We are also leveraging our experience in targeting signaling pathways in seeking to develop targeted drug candidates including CUDC-427, a small molecule antagonist of the inhibitor of apoptosis, or IAP, proteins, and CUDC-907, a dual phosphoinostide-3 kinase, or PI3K, and histone deacetylase, or HDAC, inhibitor. Our licensee Debiopharm is advancing the clinical development of the heat shock protein 90, or HSP90, inhibitor, Debio 0932.
We initiated a phase 1 study of CUDC-427 in July 2013. On November 5, 2013, we received written notification from the United States Food and Drug Administration, or FDA that our Phase 1 study of CUDC-427 has been placed on partial clinical hold following the report of death of a patient who progressed to liver failure approximately one month following the discontinuation of CUDC-427 dosing. Under this partial clinical hold, new patients may not be enrolled in the study until we provide the FDA with requested additional data and analysis on patients treated with CUDC-427 and a proposed protocol amendment is submitted to and accepted by the FDA. We expect to respond to the FDA's requests for additional information and also plan to submit an amendment to the current protocol in a timely manner.
Erivedge® (vismodegib) capsule. Erivedge is a first-in-class orally-administered small molecule Hedgehog pathway inhibitor developed under collaboration with Genentech. Erivedge was discovered by Genentech and jointly validated by Genentech and Curis through a series of preclinical studies. Pursuant to this collaboration, Genentech and Roche are responsible for clinical development, and Genentech (in the U.S.), Roche (outside the U.S., excluding Japan) and Chugai (in Japan) are responsible for commercialization of Erivedge. We are eligible to receive cash payments upon the successful achievement of specified clinical development and regulatory approval milestones, as well as royalties related to commercial sales of Erivedge.
In January 2012, based on the results of the phase 2 pivotal ERIVANCE BCC clinical study, the U.S. Food and Drug Administration, or FDA, approved Erivedge for treatment of adults with BCC that has spread to other parts of the body or that has come back after surgery or that their healthcare provider decides cannot be treated with surgery or radiation. We refer to this indication as advanced BCC. The ERIVANCE BCC study enrolled 104 advanced BCC patients (71 had locally advanced and 33 had metastatic disease) from 31 study centers in the US, Australia and Europe. The study showed that Erivedge substantially shrank tumors or healed visible lesions, as defined by objective response rate, in 42.9 percent of patients with locally advanced and 30.3 percent of patients with metastatic BCC as assessed by independent review. The most common adverse events included muscle spasms, hair loss, altered taste sensation, fatigue and weight loss. Serious adverse events (SAEs) were observed in 26 patients (25 percent), however of these only four patients (4 percent) had SAEs that were considered to be related to treatment with Erivedge. Fatal events were reported in seven patients (7 percent) although none were considered by investigators to be related to treatment with Erivedge. In all seven cases, patients had other pre-existing diseases or symptoms that were related to their presumed cause of death.
In May 2013, Australia's Therapeutic Goods Administration, or TGA, approved Erivedge, resulting in a $4,000,000 milestone payment to us. In July 2013, the European Commission granted conditional approval for the marketing of Erivedge in all 28 European Union member states. This conditional approval makes Erivedge the first licensed treatment in
Europe for advanced BCC and also resulted in a $6,000,000 milestone payment to us from Genentech. A conditional marketing authorization is granted to medicinal products with a positive benefit/risk assessment that satisfy an unmet medical need and whose availability results in a significant public health benefit. Under the provisions of the conditional approval, Roche is expected to provide additional data on Erivedge in advanced BCC from the ongoing global safety study, known as STEVIE, which is an international, single-arm, open-label multicenter trial in patients with advanced forms of BCC. An interim analysis from STEVIE presented at the American Society of Clinical Oncology's, or ASCO, 2013 Annual Conference confirmed a similar safety profile to that observed in the ERIVANCE BCC study.
In addition to the United States, Australia and European Union, Erivedge is approved in several other countries and Roche has also filed several new drug applications for marketing registration with health agencies in other territories. Erivedge's regulatory approvals and Roche's submissions in other territories are based on positive clinical data from the ERIVANCE BCC study.
In addition to the lead indication of advanced BCC, Genentech evaluated Erivedge in a single-arm, three cohort phase 2 clinical trial to treat less advanced forms of BCC. Roche expects to present data from this study at a medical meeting during the first quarter of 2014. Roche has also initiated a randomized, placebo controlled phase 2 study to investigate the efficacy of 12 weeks of Erivedge treatment (versus placebo) prior to surgery in previously untreated BCC. The primary endpoint of this study is the percentage change in BCC tumor area following 12 weeks of Erivedge or placebo therapy.
Outside of BCC, in October 2013 Roche also initiated a phase 1b/2 clinical trial to investigate the safety and efficacy of Erivedge in patients with relapsed/refractory acute myelogenous leukemia, or AML, and relapsed/refractory high-risk myelodysplastic syndrome, or MDS. In contrast to BCC, these two clinical conditions are driven by mechanisms that are not linked to mutations in the Hedgehog pathway. It is believed that selective targeting and blocking of the Hedgehog signaling pathway may have an effect on leukemic (stem) cell proliferation and survival.
According to Roche, the open-label, non-randomized study is expected to enroll approximately 60 patients into two cohorts. Patients in Cohort 1 will receive 150 milligrams of Erivedge alone once daily, and patients in Cohort 2 will receive the same dose of Erivedge once daily in combination with the standard dose of cytarabine administered for 10 days. The primary endpoint of the trial is the overall response rate after 8 weeks of treatment. The secondary endpoints include overall response rate at any time during treatment, duration of response, overall survival, and safety and pharmacokinetics of the study drug(s).
In addition to Genentech/ Roche sponsored studies, several third-party investigators are also conducting clinical trials with Erivedge in BCC as well as in various other cancers.
Pursuant to the terms of our collaboration agreement with Genentech, we are entitled to a royalty on net sales of Erivedge that ranges from 5% to high single digits of global Erivedge sales, and which escalates within this range with increasing product sales. The royalty rate applicable to Erivedge may be decreased to a low-to-mid single digit royalty in certain specified circumstances, including when a competing product that binds to the same molecular target as Erivedge is approved by the applicable regulatory authority and is being sold in such country by a third party for use in the same indication as Erivedge or when there is no issued intellectual property covering Erivedge in a territory in which sales are recorded.
In December 2012, our wholly-owned subsidiary, Curis Royalty, received a $30,000,000 loan at an annual interest rate of 12.25% pursuant to a credit agreement with BioPharma Secured Debt Fund II Sub, S.ŕ r.l., a Luxembourg limited liability company managed by Pharmakon Advisors, or BioPharma-II. In connection with the loan, we transferred to Curis Royalty our right to receive certain future royalty and royalty-related payments on the commercial sales of Erivedge that we may receive from Genentech. The loan and accrued interest will be repaid by Curis Royalty using such royalty and royalty-related payments. To secure repayment of the loan, Curis Royalty granted a first priority lien and security interest (subject only to permitted liens) to BioPharma-II in all of its assets and all real, intangible and personal property, including all of its right, title and interest in and to the royalty and royalty-related payments. The loan constitutes an obligation of Curis Royalty, and is intended to be non-recourse to us. Under the terms of the loan, quarterly royalty payments received by Curis Royalty from Genentech will first be applied to pay (i) escrow fees payable by us pursuant to an escrow agreement between Curis, Curis Royalty, BioPharma-II and Boston Private Bank and Trust Company, (ii) our royalty obligations to academic institutions, (iii) certain expenses incurred by BioPharma-II in connection with the credit agreement and related transaction documents, including enforcement of its rights in the case of an event of default under the credit agreement and (iv) expenses incurred by us enforcing our right to indemnification under the collaboration agreement with Genentech. Remaining amounts, subject to caps of $1,000,000 per quarter in 2013, $2,000,000 per quarter in 2014 and $3,000,000 per quarter in 2015, will be applied first, to pay interest and second, principal on the loan. Curis Royalty will be entitled to receive the remaining amounts above the caps, if any, and we remain entitled to receive any contingent payments upon achievement of clinical development objectives. Curis Royalty retains the right to royalty payments related to sales of Erivedge following repayment of the loan.
The final maturity date of the loan will be the earlier of the date when the principal is paid in full and the termination of Curis Royalty's right to receive royalties under the collaboration agreement with Genentech. At any time after January 1, 2017, Curis Royalty may, subject to certain limitations, prepay the outstanding principal of the loan in whole or in part, at a price equal to 105% of the outstanding principal on the loan, plus accrued but unpaid interest. The obligations of Curis Royalty under the credit agreement to repay the loan may be accelerated upon the occurrence of an event of default as defined in the credit agreement. During 2013, Curis Royalty began making payments to BioPharma-II upon receipt of the Erivedge royalties. The amounts paid through September 30, 2013 were less than the interest accrued through the repayment dates resulting in a total of $754,000 being added to the outstanding principal. As of September 30, 2013, Curis Royalty owed a total of $31,068,000, gross, to BioPharma-II comprised of principal and accrued interest.
We recognized $2,550,000 of royalty revenue from Genentech's net sales of Erivedge during the nine months ended September 30, 2013 and an aggregate of $4,080,000 in royalty revenues since Erivedge was approved. As indicated above, we expect that some or all of such royalty revenues will be used to pay interest under the loan that Curis Royalty received from BioPharma-II, subject to quarterly caps.
We are also obligated to make payments to university licensors on royalties that Curis Royalty earns in all territories other than Australia in an amount that is equal to 5% of the royalty payments that Curis Royalty receives from Genentech for a period of 10 years from the first commercial sale of Erivedge, which occurred in February 2012. For royalties that Curis Royalty earns from Roche's potential future sales of Erivedge in Australia, we will be obligated to make payments to university licensors in an amount that is equal to 2% of Roche's direct net sales in Australia until April 2019, after which the amount will decrease to 5% of the royalty payments that Curis Royalty receives from Genentech for the remainder of the period ending 10 years from the first commercial sale of Erivedge, or February 2022. We recorded cost of royalty revenues of $127,000 and $304,000, respectively, during the nine months ended September 30, 2013 and 2012, respectively.
Targeted Cancer Drug Candidates
CUDC-427. In November 2012, we licensed from Genentech the exclusive, worldwide rights for the manufacture, development and commercialization of a small molecule Smac mimetic drug candidate, CUDC-427, that is designed to promote cancer cell death by antagonizing inhibitor of apoptosis, or IAP, proteins. Under the terms of the license agreement, we have the sole right and responsibility for all research, development, manufacturing and commercialization activities related to CUDC-427. Genentech will be entitled to milestone payments upon the first commercial sale of CUDC-427 in certain territories and a tiered low-to-mid single-digit royalty on net sales of CUDC-427, if any.
IAP proteins are a family of functionally and structurally related proteins that promote cancer cell survival by inhibiting programmed cell death, a process also referred to as apoptosis. Using IAP proteins and other anti-apoptotic factors, cancer cells evade cell death in response to a variety of signals, including those provided by anti-cancer agents such as chemotherapy, or naturally occurring inflammatory and immune signals transmitted through members of the tumor necrosis factor, or TNF family. Evasion from apoptosis is a fundamental mechanism whereby human cancers develop resistance to standard anti-cancer treatments. IAP inhibitors such as CUDC-427 are designed to counteract the effects of IAP proteins, thus shifting the balance away from cancer cell survival and allowing apoptosis to proceed.
We initiated a phase 1 study of CUDC-427 in July 2013. On November 5, 2013, we received written notification from the United States Food and Drug Administration (FDA) that our Phase 1 study of CUDC-427 has been placed on partial clinical hold following the report of death of a patient who progressed to liver failure approximately one month following the discontinuation of CUDC-427 dosing. Under this partial clinical hold, new patients may not be enrolled in the study until we provide the FDA with requested additional data and analysis on patients treated with CUDC-427 and a proposed protocol amendment is submitted to and accepted by the FDA. We expect to respond to the FDA's requests for additional information and also plan to submit an amendment to the current protocol in a timely manner.
A clinical hold is an order issued by FDA to the sponsor of an IND to delay or to suspend a clinical investigation. A clinical hold, including a partial clinical hold, involves the FDA (1) requiring additional information and/or data, (2) reviewing the additional information and/or data, and (3) after the review, informing the sponsor that they can proceed. A partial clinical hold is defined as a delay or suspension of only part of the clinical work requested under the IND (e.g., a specific protocol or part of a protocol is not allowed to proceed; however, other protocols or parts of the protocol are allowed to proceed under the IND).
The study was designed to determine the maximum tolerated dose (MTD) and recommended single-agent Phase 2 dose of CUDC-427 using a continuous, twice-daily treatment schedule. One patient with breast cancer metastatic to the liver, lungs, bone and ovaries developed serious adverse events related to liver function, including increases in serum levels of AST and ALT enzymes and bilirubin. Unlike prior clinical experience with CUDC-427, this patient's liver enzyme levels did not recover in response to CUDC-427 discontinuation, and the patient died of liver failure approximately one month following the discontinuation of CUDC-427 dosing. While elevations in liver enzyme levels have previously occurred in patients receiving CUDC-427, no other patients in this or a prior Phase 1 CUDC-427 trial have experienced a serious adverse event of this nature. There are no patients currently being treated with CUDC-427 in this study as all other patients enrolled in this study have discontinued dosing due to disease progression or patient or physician discretion during the ordinary course of the study.
We licensed CUDC-427 from Genentech, which completed enrollment in a phase 1 clinical trial of CUDC-427 (previously GDC-0917), in which 42 patients with refractory solid tumors or lymphoma received daily oral doses of CUDC-427 for two weeks, followed by a one week rest period until disease progression or study discontinuation for any other reason. Results of this phase 1 study were presented during an oral session at the ASCO 2013 Annual Conference in June 2013. In this study, patients were enrolled across 11 cohorts and received CUDC-427 monotherapy at doses ranging from 5 mg to 600 mg daily. Unconfirmed complete responses were reported in 2 patients, including one patient with ovarian cancer and another with mucosa-associated lymphoid tissue (MALT) lymphoma. Additionally, one patient experienced a mixed response and four patients (one patient each with breast cancer, sarcoma, small cell lung cancer and Kaposi's sarcoma) had stable disease for greater than or equal to three months, including a patient on study for greater than 10 months. The maximum tolerated dose, or MTD, of CUDC-427 was not determined in this study, although plasma concentrations in the order of preclinically predicted ED90 were reached. ED90 refers to the dose that leads to 90% of the maximal response. There were three deaths reported during the study, none of which was considered related to the study drug: two died due to progression of breast cancer and one patient died due to pneumonia. Adverse events (AEs) that resulted in treatment discontinuation were Grade 3 fatigue (one patient), Grade 2 QTc prolongation (one patient), Grade 2 drug hypersensitivity (one patient), Grade 2 pneumonitis (one patient), and Grade 3 pruritus/Grade 2 rash (one patient). Other treatment related AEs that were equal to or greater than Grade 3 in severity in more than one patient were elevated levels of liver enzymes (two patients at 450 and 600 mg dose). Biomarker analyses of tumor samples (obtained from two patients) and peripheral blood cells (obtained from all patients) showed changes that were consistent with CUDC-427's mechanism of action.
CUDC-907. CUDC-907 is an orally bioavailable drug candidate designed to predominantly inhibit certain isoforms of phosphoinositide-3-kinase, or PI3K (mainly PI3K- alpha, delta and beta) and select classes of histone deacetylase, or HDAC enzymes (primarily Classes I and IIB). In January 2013, we initiated a phase 1 clinical trial in patients with advanced lymphoma or multiple myeloma. This first-in-human study is designed to assess the safety (including the MTD), pharmacokinetics, and anti-cancer activity of CUDC-907. In July 2013, we amended the protocol of the ongoing phase 1 study to include two additional dosing regimens, wherein oral CUDC-907 will be administered either two times per week or three times per week. Additionally, exploratory biomarkers will be assessed for the activity of CUDC-907.
In November 2011, we entered into an agreement with The Leukemia & Lymphoma Society, or LLS, under which LLS agreed to make up to $4,000,000 in milestone payments to support our ongoing development of CUDC-907 for patients with relapsed or refractory lymphoma, contingent upon the Company's achievement of specified clinical objectives. As of September 30, 2013, we have earned $1,650,000 in milestone payments under our agreement with LLS. Under certain conditions associated with the successful partnering and/or commercialization of CUDC-907 in the specified indications, we may be obligated to make payments, including royalties, to LLS up to a maximum of $10,000,000. This obligation is limited to 2.5 times the amount we receive from LLS, and, as of September 30, 2013, the maximum obligation, assuming that CUDC-907 successfully progresses through future clinical trials, would be $4,125,000. Our scientists are also conducting ongoing preclinical studies of CUDC-907 in solid tumor cancers and we are currently planning a phase 1 study in patients with solid tumors.
Debio 0932. In August 2009, we granted a worldwide, exclusive royalty-bearing license to develop, manufacture, market and sell our HSP90 inhibitor technology, including Debio 0932, to Debiopharm. Debiopharm has assumed all future development responsibility for Debio 0932 and Debiopharm or a Debiopharm licensee will incur all future costs related to the development, registration and commercialization of products under the agreement.
In April 2010, Debiopharm initiated a phase 1 clinical trial to evaluate the safety of Debio 0932 given orally to patients with advanced solid tumors. In 2011, Debiopharm successfully advanced Debio 0932 through the dose escalation portion of this phase 1 study and determined 1000 mg daily to be the recommended dose for further development. In the beginning of 2012, Debiopharm advanced Debio 0932 into the phase 1b expansion portion of the study at this 1000 mg daily dose level. The primary objectives of this study were to further assess the safety profile, pharmacokinetics and pharmacodynamics of Debio 0932 at the oral 1000 mg daily dose and to make a preliminary assessment of its anti-tumor activity. Debiopharm completed the phase 1b expansion portion of the study, enrolling approximately 30 patients with advanced solid tumors, including patients with non-small cell lung cancer, or NSCLC.
In August 2012, Debiopharm initiated the HALO (HSP90 inhibition And Lung cancer Outcomes) phase 1/2 clinical trial of Debio 0932 in combination with various chemotherapy regimens in patients with stage IIIb or IV NSCLC without known EGFR mutations. In the phase 1 portion of this study, various doses of Debio 0932 are being investigated in combination with either cisplatin/pemetrexed or cisplatin/gemcitabine in treatment-naďve patients, and with docetaxel in previously treated patients. Once a recommended phase 2 dose of Debio 0932 in combination with the chemotherapy regimen(s) has been identified, Debiopharm expects to initiate the randomized, double-blind, placebo-controlled phase 2 portion of the study. The phase 2 portion of the HALO trial is expected to enroll approximately 140 eligible patients with NSCLC, who will be randomized to receive standard of care chemotherapy treatment in combination with either Debio 0932 or placebo. The primary objective of this study is to compare the effect of adding Debio 0932 to combination chemotherapy with cisplatin/pemetrexed and cisplatin/ gemcitabine on the rate of progression-free survival at 6 months in first-line therapy of patients in this study population. Under our agreement with Debiopharm, we are eligible for our next milestone payment when Debiopharm treats its fifth patient in a phase 2 clinical trial, which we expect could occur in 2014. We have received $13,000,000 in milestone payments to-date from Debiopharm under this collaboration.
In October 2013, Debiopharm initiated an open-label, multicenter phase 1 dose-finding study of Debio 0932, in combination with everolimus, an inhibitor of mammalian target of rapamycin (mTOR), in patients with advanced or metastatic renal cell carcinoma, or RCC, who have been previously treated with a VEGF-directed tyrosine kinase inhibitor. This dose escalation study is designed to determine the safety and maximum tolerated dose of Debio 0932.
The pharmacokinetic profiles and any potential drug-drug interactions between the two agents will also be assessed. The trial also includes an expansion cohort of 25 patients with metastatic clear cell RCC. While approved monotherapy treatments for RCC, including mTOR inhibitors, have been shown to be effective in RCC, improved therapies are needed to enhance the depth and duration of response. Several mTOR signaling pathway components such as mTOR, AKT and LKB1 are HSP90 client proteins. Mechanistic data suggest the potential for improved efficacy through dual mTOR and HSP90 inhibition, which may also prevent the development of acquired resistance to this cancer therapy.
CUDC-101/EGFR Preclinical Program. CUDC-101 is a drug candidate that is designed to target epidermal growth factor receptor, or EGFR, human epidermal growth factor receptor 2, or HER2, and certain HDAC enzymes. In October 2012, we initiated a phase 1 clinical trial of an oral formulation of CUDC-101 in cancer patients. We subsequently terminated this study as the bioavailability observed in the first cohort of patients was too low to achieve effective drug levels with this formulation. We are currently pursuing the development of alternative formulations that may provide improved oral bioavailability and allow us to progress CUDC-101 towards clinical testing and expect that we will have sufficient data to determine whether to advance CUDC-101 into clinical development in the coming months.
We initially developed CUDC-101 as an intravenous formulation and we completed two clinical trials with this formulation, including a phase 1 dose escalation clinical trial of CUDC-101 in 25 patients with advanced, refractory solid tumors and a phase 1 expansion trial that tested CUDC-101 in 46 patients with specific tumor types, including breast, gastric, head and neck, NSCLC or liver cancers. In 2011, we began testing an intravenous formulation of CUDC-101 in a phase 1 clinical trial in patients with locally advanced squamous cell carcinoma of the head and neck in combination with the current standard-of-care of cisplatin and radiation. In April 2013, we determined that we would discontinue enrolling patients in this study and that the future development of CUDC-101 would be dependent on our ability to successfully develop an oral formulation of CUDC-101. Our decision was based largely on the difficulty in enrolling patients in this trial as well as our desire to direct our available financial resources to the development of CUDC-427 and CUDC-907.
In addition to CUDC-101, we are exploring additional preclinical compounds that are designed to target specific aspects of the EGFR receptor.
Since our inception, we have funded our operations primarily through license fees, contingent cash payments, research and development funding from our corporate collaborators, the private and public placement of our equity securities, debt financings and the monetization of certain royalty rights. We . . .


text:
News & Events
Mon 20th Oct 2014
Thu 9th Oct 2014
Fri 12th Sep 2014
Tue 5th Aug 2014
Mon 30th Jun 2014
Tue 17th Jun 2014
Tue 3rd Jun 2014
Thu 1st May 2014
Youth Work"Being here has helped me develop as a person. I've made friends; I've been able to accept myself for what I am, I've been able to build bridges over family troubles and most importantly I've been able to be myself for the first time." (Nick, tenant)
Our youth work includes activities and sports sessions in our Activity Centre on site, "Come Dine With Me" sessions where young people learn about independent living and healthy eating, and music workshops. We also work with young people in their own space, places they have chosen for themselves- street corners, parks and outside shops. We chat with them about a variety of topics, including relationships/family issues, local community issues, drugs & alcohol, law & order, sexual health, bereavement, domestic abuse and self harm.
We run a number of youth activities in Colchester, funded by Youth Opportunity Fund, High Sheriff's fund and Essex County Council. Work is carried out at youth groups including Myland and other detached work in Colchester.


text: My husband travels to Cambridge on business regularly and he initially stayed in a Hotel. That is nice at from time to time but the attraction weakens quickly and what one really wants is a "Home away from Home". So I surfed the Net and discovered Yourspace Apartments and they have been a perfect fit! You get a lot more...more


text:
UFOP is Recruiting
Looking for a chill, laid back environment with a wealth of experienced lifetime subscription members? Wanting to finally finish that pesky STF which never seems to get completed because your group falls apart? Need someplace to just kick back and relax while enjoying everything Star Trek Online has to offer?
Well look no further... The United Federation Of Pirates is looking for new members to swell its ranks after being an exclusive fleet since Beta. Benefits include a fully stocked fleet bank, ventrillo server, and a forum to keep in touch with fellow fleet members while you're at work!
Register on our forums and see if we're what you're looking for today!
PVE and PVP members are welcome
Beam me up Scotty...
Hello all, we're still open for business and are kicking butt in all aspects of STO. Looking for an experienced team of PvPers? We've got 'em. Looking for a very fast run through infected? No problem. Contact either myself or @nemesischiken for recruitment details.
|All times are GMT -7. The time now is 10:55 PM.


text:
Charming 1858 Hand-Colored Christmas Print by Pasquier
browse these categories for related items...
All Items: Fine Art: Prints: Lithographs: Pre 1900: item # 587293
GlitzQueen History and Art to Wear
By Appointment
Albuquerque, NM
Guest Book
Free U.S. Priority Shipping
(& Gift Wrap if Desired)
All the delights of a Victorian Christmas are here: the candle-lit tree, the heap of toys, the garland 'round the picture, the tankards on the sideboard, the warmth and friends and family and, of course, the beautifully dressed and appropriately awed children.
Titled "The Christmas Tree", this is a truly gorgeous scene - drawn by James Abbott Pasquier (who would illustrate novels of Thomas Hardy), and then vividly hand-colored by someone exceedingly talented. It's probably from the "London Illustrated News" and there's printing on the reverse, but it doesn't show through. These were published to be framed and enjoyed.
Condition of this print is excellent and it's already nicely matted to a size of about 13 1/4" x 11", with a visible image area about 9" x 7". Provenance is an antiques shop in East Anglia. If interested in another scene of Victorian family festivity, please see our "Magic Lantern" print from the same source and era. They'd be lovely framed to match and hung together.
There's no charge for U.S. shipping and gift wrap is always available when desired. Please e-mail to confirm availability, order or request more photos. Thanks for looking!


text:
5:18 am
Spetember 29th, 2010…. nintendo fall confernece….
what did we learn….
Feb 26th, 2011…. Nintendo 3ds hits japan….
asking price…… 25,000 Yen……whats that in dollars… $300…. yupp thats right 300….
I my self am not a big fan of 3d dont see the point(seen re:a 3d in the theater, wasn't impresed with the 3d, would have been better non)…..but to ask 300 for just a handheld??? there was an article on kotaku showing the prices over the years for the Gameboy series…. and nothing has asked 300…. holly crap…. i could buy a wii and a crap ton of games… i could buy a 360 or a PS3….i could get just 2 base psp's or ds's…..
im sorry…. nintendo, to me, is making a huge mistake with this…. for one its to expensive… and the only reason initally that it will sell. is :
1. people need to have the newest, biggest and best-ist thing.
2. OMG(the little kids say) its a new ds trade in old one to get new or keep old and still buy new caz i want parents to do so.
the thing is…. the Ds isn't the best selling colsole of all time… im sorry…. they jsut keep releasing the same thing….just adding and substracting things…. it isn't a new thing. and the reason why it sells caz its the newest thing…(but not really)….see i still have a play GBA games…. can't do it on the newer ones caz thats gone….
here is the other thing that is gonna ruin it…. you give a 3d system to a little kid.. thats gonna happen. they play it like the alwasy have. really close to their face. when sony's stuff went 3d they posted a warning about keeping safe distances and taking breakes becasue of the strain it cna cause…. kids arnt going to want to stop… espically if they make a 3d pokemon…. theres gonan be problems…
the PS2 still ranks in my books as the best selling of all time…. caz it was one thing and it just kept selling. yea they slimmed it down but most colsoles do that after its so old…..but the library is so huge with games….. most of the stuff for the DS besides the first party stuff and the few 3rd are all casual games…. theres just no substance in it for me….
Im sorry for ranting…. but after a bunch of crappy gaming news today i am just very disappointed in nintendo and where things are going….
forgive me
10:59 am
Opinions are always welcome since everyone can bring a new perspective to a topic.
Just to give you an idea, the Wii released for 25,000 Yen in Japan but over here it ended up being $249.99 which I think will be the price for the 3DS come march 2011. When you consider a single pair of 3D glasses is $99-199 and a 3D enabled TV can run you at least $1,000 suddenly $249.99 for a handheld that can play 3D movies, 3D games, take 3D pictures (and has many other features) doesn't seem that expensive.
As for your problem with the DSi and DSi XL not playing GBA games I can tell you that I own a DSi (got a DS Phat, then a Lite and now a DSi) but I also own a GBA SP and a GBA Micro so I'm set in that category. Backwards compatibility is always a plus but at some point something has to go to bring a product to market at a lower price.
Finally, doctors have said there won't be a serious problem with the 3DS because the screen is smaller and uses a different technology from that of 3D glasses. More studies should be in order, but so far so good.
Nice rant overall
1:10 pm
Yaminoshyuen said:
here is the other thing that is gonna ruin it…. you give a 3d system to a little kid.. thats gonna happen. they play it like the alwasy have. really close to their face. when sony's stuff went 3d they posted a warning about keeping safe distances and taking breakes becasue of the strain it cna cause…. kids arnt going to want to stop… espically if they make a 3d pokemon…. theres gonan be problems…
Well you could say the same about the 3D PS3, Kids are going to want to play that endlessly without breaks, hell even adults are prone to doing that. I've found myself and my friends playing LittleBigPlanet and completely losing track of time.
I do agree the price tag is a bit steep but considering the power of the console and the added 3D Without Glasses gimmick it does seem fair. I won't be getting one immediately but I do think after a price drop I'll look to invest in one.
Most Users Ever Online: 349
Currently Online:
10 Guest(s)
Currently Browsing this Page:
1 Guest(s)
Member Stats:
Guest Posters: 195
Members: 15877
Moderators: 0
Admins: 3
Forum Stats:
Groups: 5
Forums: 23
Topics: 998
Posts: 8859
Newest Members: Madhatter


text: Cooper River Distillers is the first legal distillery in Camden, NJ since at least Prohibition. We began production of our first product – Petty's Island Rum – in April of 2014, and plan to continue crafting more one-of-a-kind spirits including bourbon and rye whiskeys in coming months. All of our spirits are hand-made from scratch in downtown Camden, New Jersey. Check back here often or sign up for our newsletter to stay on top of what's new with South Jersey's finest craft spirits!


text:
DID YOU KNOW? By Jeff Suess firstname.lastname@example.com Ulysses S. Grant's boyhood home in Georgetown, Ohio, reopened this month after a $1.4 million restoration that has returned the home to how it appeared in 1839, the year Grant left for the West Point military academy. "The Grant Boyhood Home is a gem of Ohio history, and […]
Grant's boyhood home is restored
04/26/13 at 8:34am by jsuess | Comments
Rixey has a long HOF legacy
04/25/13 at 7:58am by jsuess | Comments
Southpaw won 179 games from 1921-33 By Mike Dyer email@example.com Before Eppa Rixey heard of his election to the Baseball Hall of Fame in January 1963, his 10-year-old grandson Eppa Rixey IV answered the phone call that delivered the news. "It seemed like the phone rang – and I almost can't believe that I answered […]
'Supermarket Ambush' shook town
04/24/13 at 8:34am by jsuess | Comments
Exhibit lays out history behind bloody 1957 police shootout By John Johnston firstname.lastname@example.com The bullet-riddled bodies had been removed from the supermarket by the time Charles Hicks arrived for work. Even so, "It wasn't a pretty sight," Hicks, an 86-year-old Anderson Township resident, recalled the other day. "There were all kinds of gunshot holes in […]
Reds turned green for St. Pat's
04/24/13 at 8:24am by jsuess | Comments
DID YOU KNOW? By Jeff Suess firstname.lastname@example.com The Cincinnati Reds started a baseball tradition on March 17, 1978, by donning green uniforms for St. Patrick's Day. General Manager Dick Wagner had special uniforms ordered from their outfitter, Koch Sporting Goods. Everything red was done in green – the cap, the names, the logo, the piping […]
Judge Landis cleaned up baseball
04/17/13 at 11:51am by jsuess | Comments
DID YOU KNOW? By Jeff Suess firstname.lastname@example.com Judge Kenesaw Mountain Landis had a reputation as an iron-handed, independent ruler when he was chosen as the first commissioner of baseball in 1920 to clean up the game after the infamous Black Sox Scandal. Landis was legendary as a federal judge and the "savior of baseball," but […]
Hobnob with William Howard Taft April 7
04/05/13 at 1:29pm by jsuess | Comments
By Jackie Demaline and Janelle Gelfand Well – hang out with a life-size wax figure of the 27th President of the United States (1909–1913) and later the 10th Chief Justice of the United States (1921–1930). Madame Tussauds' wax Taft (part of the wax museum's complete collection of Presidents) will be a guest at the Taft […]
About Our HistoryWe cherish our history -- and want to share it. Our reporters will be looking to tell the stories about the people, places and events that have shaped Greater Cincinnati and Northern Kentucky. This new venture becomes all the more interesting if you join in. Tell us what you want to know more about. Offer to write some stories yourself. Point us in new and fascinating directions.
- March 2014
- February 2014
- December 2013
- November 2013
- October 2013
- September 2013
- August 2013
- July 2013
- June 2013
- May 2013
- April 2013
- March 2013
- February 2013
- January 2013
- December 2012
- November 2012
- October 2012
- September 2012
- August 2012
- July 2012
- June 2012
- May 2012
- April 2012
- March 2012
- February 2012
- January 2012
- December 2011
- November 2011
- October 2011
- September 2011
- August 2011
- July 2011
- June 2011
- May 2011
- April 2011
- March 2011
- February 2011
- January 2011
- December 2010
- November 2010
- October 2010
- September 2010


text:
Related Photo Galleries
"Blowfish" is the name given to the '69 Barracuda race car driven to record-setting speeds by owner/driver George Poteet. Under the hood is a 1,000hp four-cylinder engine with only 175 ci of displacement! The racer set a 255.412-mph record in the F/Blown Fuel Competition Coupe class on its first outing at the salt.


text:
Hi guys Its me again, I am ready to give up the fight with earthlink support. I see no need to continue arguing that I should use my own modems and get no support from Earthlink DSL. My latest attempt was met by failure. I hooked up the motorola 2200-02 modem with a 500mA power supply and got the message No DSL synchronisation in the modem setup page. I call earthlink to see if they will help and got told they can not help me because they do not support third party modems. Thought about buying a zytel modem, like the ones they support, and thought why should I continue to resist the support people at earthlink DSL?? I buy this modem and they will tell me they do not support it and tell me goodbye. The motorola modem was also running hot to touch this did not sound good to me. This could still be the wrong powersupply for this unit as I have not found the corerect P. S. AFAIK. I called to order today and my call was dropped on call one and then call two they transfer me to a sales line that dropped me again. I told them that I was contacting you guys for help and they still tell me same story, buy a modem. One last question,I have is will DSL work on a line that is a basic lifeline with the cheapest service??? We had to apply with a form for this lifeline service and it is cheap. I hate to buy modem and then have to pay early termination fees if this service does not work and get a refund on the modem I ask tech support and they pause and say we test for service at time of sale and determine if service will work. Sounded like he was asking a superviser about that one. Short on time got to go let me know if you need any other informationmatt8911
Hi again I am updating this post to add information about this subject (No Snyc on Basic lifeline service). This is the second or third month in my struggle and here are the updates.Most of time spent searching for the correct Power supply for the 2Wire modem/Router and just picked one up at ATT store last week. Again tried to work with Earthlink Tech support with all hardware up and waiting for setup. I had 2wire connected via ethernet to my GA-EP45-UD3LR HomeBuild PC. I erased the old username and password and tried entering my earthlink user and password. Now I am set I thought, this should do it!! All other settings were same as ATT setup in the past. This should work with a little help I thought? Called Earthlink Tech support and after a little run around on the phone Tech support finally told me they will not support third party modem/router equipment, even though I told them other people were using them with their service. I ask them again if it might be the limitations of the phone service and they decline to give me a clear answer only that I need to buy their modem. Then I started to ponder cancellation of service(even though there is no service). This leads to more phone tag and wonder about that 150.00 early termination fee (termination from what???). They smooth talk me in to waiting a week or two more. To be continued.......
Finally caved and ordered the Zyxel modem, which arrived in about one week. Modem started to operate after a technician "Truck Roll". Speed is 153.5 KB/sec down and 40.1KB/sec up right now with no modifications or tweaks.Matt8911 out.
Hi again I just did some tests with my new account of matt8911test. I have a link for all of you from tweak tool.»/tweakr/block:···a=normalThanks Guys for any help.


text:
Hilton Garden Inn Springfield800 Hall of Fame Avenue, Springfield, Massachusetts, 01105, USA TEL: +1-413-886-8000 FAX: 1-413-886-8100
A fee of up to 250 USD will be assessed for smoking in a non-smoking room. Please ask the Front Desk for locations of designated outdoor smoking areas.
Find where we are located
View the Maps & Directions Page
Package includes overnight accommodations and two adult tickets to Six Flags® New England Hurricane Harbor.
All rates are subject to hotel availability; rate does not include taxes, gratuities or other incidental charges; certain length of stay restrictions may apply. Early departure fee may apply. This offer may not be combined with any other discounts or offers. If you are not interested in making this reservation online, please call our Internet Customer Center at 1-800-774-1500 or click here for a complete list of Hilton Reservations Worldwide phone numbers. Please request plan code "P4".


text:
Shopping Cart
Shopping Cart
The Female Buddha: Discovering the Heart of Liberation and Love
(please contact us for discounts on bulk orders)
Choose from 10 Stunning Photos
In Stock orders filled the next day, others orders 1-2 weeks, we will contact you with the wait time
40% off $65! ~ free USA shipping
Guanyin Workshop for Women
Sept 20, 2014 $135 with with complimentary book
We'll share stories of Guanyin, contemplations and connect the dots to her inspiration & our lives through personal reflection & sharing. Click here for details.
You must add INTERNATIONAL SHIPPING COSTS for books, photos & cards. Use the drop down menu here:
*Order up to 10 photos for the same shipping price.
**When adding 1-2 sets of cards or less than 10 photos to a book order it is NOT necessary to add additional shipping costs for the cards or photos.
Please include International Shipping Costs!


text:
Does anyone know of a way to automatically install a specific web slice on to machines running Win 7 and IE8 ?
Specifically, its this slice
Click CEOP Button - Add-ons Gallery
I have tried copying the source files and importing the corresponding registry entry related to it but this does not have any effect.
There are currently 1 users browsing this thread. (0 members and 1 guests)


text:
Riedel Sommeliers Alsace Glass 4400/05by Elizabeth
My husband and I have used Riedel Sommeliers wine glasses for many years. While we have several sizes, we have always favored the small Alsace glass for white wines. Oddly, many of them broke and we were told that there was some sort of defect in their manufacture (None of the other glasses broke). For years we tried to replace them and we were told that they were no longer manufactured We recently found them on line at IWA and we are thrilled to have them again. Hopefully these will not break.


text:
You must log in to access this feature. Sign in with Twellow or Facebook to get started.
By signing in to Twellow, you indicate your agreement to our terms of service.
Simply connect with Facebook and kiss those password blues away,
or go here to reset your password.
National bestselling author Joy Déjà King is representing a new genre of young, sexy hip novels that take readers behind the velvet rope of the glamorous, but often shady entertainment industry and offers street life in all its complexity. Born in Toledo, MS, King is emerging as the urban Jackie Collins. Ms. King made her literary debut with the release of Dirty Little Secrets (under St. Martin Press) and followed it up with the best selling sequel Hooker to House Wife. A prolific writer Ms. King also secured a deal with Triple Crown Publishing for the first three installments of the very popular Bitch series.


text:
Why are unlimited users so protective of their At&t limited unlimited plans. Those plans have been pretty much neutered have'nt they. they throttle you at 3 gigs now dont they. I don't think they will be upping you back to trully unlimited anytime soon.
Because its still "unlimited". Peeps like that feeling. Get it?


text:
When the Falcons host the Washington Professional Football Team on Sunday, the visiting team will be playing a different starting quarterback than you may expect.
Washington announced on Wednesday afternoon (after multiple outlets had broken the story) that franchise quarterback Robert Griffin III will be benched in favor of Kirk Cousins against the Falcons in Week 15. This is a bit of a surprise, but not an all-out shock, given that RGIII's play has suffered in recent weeks, and the situation surrounding head coach Mike Shanahan is, at the very least, tumultuous.
Because we aren't a Redskins-affiliated outlet (obviously), I will flatly ignore the reasoning (or lack thereof) for the Griffin benching, and instead focus on the Falcons. In 5 career games (1 start), the 25-year-old Cousins has thrown for 573 yards with 4 touchdowns against 5 interceptions. However, some believe that he is a future NFL starter and his 57.4 QBR is in the respectable range that would rank him 18th among QB's this season.
We'll break down the game in full later in the week, but this seems like a small "win" for the Falcons. Even with Griffin's issues this year, there is little doubt that he is the more talented player, and against what has been a porous Atlanta defense, it is unquestionably a positive to see him on the sidelines.


text:
On Saturday, we took you inside the troubled Scientology drug treatment center in eastern Oklahoma, Narconon Arrowhead. Three deaths have occurred at the center since October, and the most recent of them, Stacy Murphy, 20, was found on the morning of July 19. A former patient of the center who kn ... More >>
We were stunned when Debrah Kitchings said it: in the 26 years since she investigated the odd death of Mary Florence "Flo" Barnett for the Los Angeles County Coroner, she has not once been asked by a reporter about what she remembers of the case. Only once in that time, she says, was she ever aske ... More >>
Credit: Vanity FairSuri Cruise, with her Scientologist parentsIn recent weeks here at the Voice, we've described the Church of Scientology's programs aimed at investigating perceived enemies, who have included former high-ranking Scientology executives, a man trying to bring to market a clean ... More >>
Elvis wasn't seduced by Scientology's siren songAfter some time away, we came back with a slew of stories this week, and naturally, our readers were ready to pounce on them. On Tuesday, we took another look at intriguing young DC-area Scientologist Tad Reeves. We're still hoping to talk to t ... More >>
Tuesday, a woman named Paulien Lombard appeared before the Riverside County, California Board of Supervisors to tell them what only a few years earlier she had kept secret: that she was a Scientologist who had worked as a spy for the church. It's a dramatic moment, and even more so if you know th ... More >>
The author of a new book on Scientology reveals to the Village Voice details of his experience being "audited" by Tom Cruise, who asked him to talk to a book, a bottle, and an ashtray for hours at a time in order to perfect his "upper indoctrination." Marc Headley's remarkable account of his ... More >>
Yesterday, after putting up our first response to the idiotic Anonymous prankster who was arrested after slathering himself with vaseline and pubic hair clippings and rubbing himself on items at the Scientology building on W. 46th Street, we received this response from our old friend Mark Bunker, al ... More >>
Alleged Beating Victim Comes Clean On 'Giuliani Lie' and Al Sharpton


text:
STARmeterSEE RANK
Up 133,373 this week
Bivas Biswas (I)
Bivas recently completed directing his latest feature film Paranoia. He was Co-Executive in charge of Production for Dirty Little Trick, an independent film starring Michael Madsen and Dean Cain. In 2008, Bivas was awarded the Arizona Filmmaker of the Year by the Phoenix Film Festival and named Best Local Filmmaker by the NewTimes Best of Phoenix ... See full bio »
More at IMDbPro » Contact Info: View agent


text:
menstruation - meaning in Hindi
Pronunciation of menstruationमेन्स्ट्रुएशन / मेन्स्ट्रूऐशन
Meanings of menstruation[Show Transliteration]
- ऋतु
- ऋतुस्राव (m)
- रजोधर्म (m)
- मासिक धर्म (m)
Inflected formsmenstruations (noun plural)
Definitions of menstruationmenstruation - noun
- the monthly discharge of blood from the uterus of nonpregnant women from puberty to menopause
- a woman does not take the gout unless her menses be stopped
- the semen begins to appear in males and to be emitted at the same time of life that the catamenia begin to flow in females
Follow us on Facebook
Synonyms of menstruation
catamenia, flow, menses, menstruum
Antonyms of menstruation
No matches.
More matches for menstruation
|menstruation cycle
|माहवारी चक्र
|menstruation cycle
|आर्तव चक्र
Information provided on menstruation
Meaning and definitions of menstruation, translation in Hindi language for menstruation with similar and opposite words. Also find spoken pronunciation of menstruation in Hindi and in English language.


text:
Lemme just share to you this picture of EPIC PROPORTIONS!!!
All Vogue Editor-in-Chief all over the world, unite for this very rare (and lemme say EPIC) occasion, of sharing one frame together in support for Fashion Night Out Japan.All I can say is: Anna Wintour is the center of the universe. Yes, she is.And can you notice, by the way they dress up, you can simply tell which Vogue country they are from. Franca Sozzani just killed it for me, I love her!This by far is the most chica and most fashyown of all class pictures ever!!!!!!PS. I kinda miss Carine Roitfeld in here… :/
Tags: vogue fashion anna wintour
fashion designer. celebrity stylist. blogger. traveler.
All contents JAMES TO THE WORLD (RJ GOROSPE) are the blogger's own unless otherwise specified, and are not to be used without his permission.
The opinions expressed here do not represent those of any organizations, individuals, or companies that the blogger might be affiliated with or employed by.
Tweet me
Powered by Tumblr. Minimal Theme designed by Artur Kim.


text:
Despite the exigencies of the Civil War, Abraham Lincoln took his entertaining duties at the White House seriously, and if the only extant culinary records of his administration were the menus of his gala state banquets and balls, one could justifiably conclude , according to food historian Poppy Cannon, that he was "a gourmet to end gourmets, a connoisseur of exquisite sensitivity [and] a bon vivant supreme."
But nothing could be further from the truth. Not prone to eating breakfast every day, it has been said that he had an egg and biscuit only occasionally. Lunch was often only an apple with a glass of milk, and dinner could be entirely forgotten unless a tray of food was forced on him. "Abe can sit and think longer without food than any other person I have ever met," Lincoln's former law partner in Chicago wrote. And, shortly after his death, Lincoln's sister-in-law recalled, "He loved nothing and ate mechanically. I have seen him sit down at the table and never unless recalled to his senses, would he think of food."
But when Lincoln did turn his attention to food, he ate heartily and never lost a boyhood taste for Kentucky Corn Cakes, Gooseberry Cobbler, Rail Splitters, Gingerbread Cookies, and Corn Dodgers. And it has been said that one of the few entrees that would tempt Lincoln was Chicken Fricassee. According to A Treasury of White House Cooking by Francois Rysavy, Lincoln "liked the chicken cut up in small pieces, fried with seasonings of nutmeg and mace and served with a gravy made of the chicken drippings."
Although Abe's favorite recipe for Chicken Fricassee has surely been lost to posterity, you can try this more recent one for Tarragon Chicken Fricassee from Gourmet Magazine:
3 1/2 to 4 pounds chicken pieces with skin and bone
3/4 teaspoon salt
1/2 teaspoon black pepper
2 tablespoons vegetable oil
1/2 cup finely chopped shallots
1 garlic clove, finely chopped
1 Turkish or 1/2 California bay leaf
1/2 cup dry white wine
1 cup heavy cream
1/2 cup reduced-sodium chicken broth
1 1/2 tablespoons finely chopped fresh tarragon
1/4 teaspoon fresh lemon juice
Pat chicken dry and sprinkle all over with salt and pepper. Heat oil in a 12-inch heavy skillet over moderately high heat until hot but not smoking, then sauté chicken in 2 batches, skin side down first, turning over once, until browned, 10 to 12 minutes total per batch. Transfer to a plate.
Pour off all but 2 tablespoons oil from skillet, then cook shallots, garlic, and bay leaf over moderate heat, stirring occasionally, until shallots are softened, about 2 minutes. Add wine and bring to a boil. Stir in cream, broth, and 1 tablespoon tarragon, then add chicken, skin side up, and simmer, covered, until just cooked through, 20 to 25 minutes. Transfer chicken with tongs to a platter and keep warm, loosely covered. If necessary, boil sauce until thickened slightly. Stir in lemon juice, remaining 1/2 tablespoon tarragon, and salt and pepper to taste. Discard bay leaf; pour sauce over chicken.
Thursday, July 14, 2011
Abraham Lincoln Chicken Fricassee
Posted by Suzy Evans, J.D., Ph.D. at 4:41 PM
Labels: Abraham Lincoln, Chicken Fricassee, Civil War, Corn Cakes
1 comment:
That's something really good to know. I only researched about chicken fricasse and Abraham Lincoln because of a blog I've seen at gourmetrecipe.com (http://blog.gourmetrecipe.com/2011/04/26/traditional-delicious-chicken-fricassee/)ReplyDelete
I thought it was just an exaggeration when the blogger said several former US Presidents took it as their favorite but as it seems, it's very true and so much more. :)
Subscribe to: Post Comments (Atom)


text:
The artwork represents a striving to reconcile the inner world of instinct and emotions, with an external world that is both beautiful and hostile
in its natural grandeur. It is an attempt to map the place where these worlds intersect.
Facebook Page
Would love to have that in my house
Most inspiring art I've seen in years… just speechless…


text: just wondering what you guys think they will do. i think they take a pass on AP. Thye signed Ahman Green and i think they wont be drafting a Rb frist round. they have so many needs that are greater right now thatn RB. They need oline which they can get through Levi Brown, Alan Branch, Amobi Okoye and Adam Carriker to help out the Dline. Laron Landry at safety assuming hes still there. Possibly a WR to help out, as well as Brady Quinn as a possibility. There are many other options and i dont see them going RB first round anymore. What do u think?


text:
October 25, 2014
January 5, 2014
ASPEN, Colo. (AP) - A Colorado sheriff's office dispatcher confirms that one person died and two people were injured when a plane crashed at the Aspen airport.
Thomas Wright, a dispatcher with the Pitkin County Sheriff's Office, says three people were aboard the plane Sunday. He says one person was severely injured and another suffered non-serious injuries.
Aspen Valley Hospital spokeswoman Ginny Dyche says the facility admitted two patients involved in the crash.
FAA spokesman Allen Kenitzer said the plane was headed from Tucson, Ariz., and crashed upon landing.
Aspen is located in the Rocky Mountains about 100 miles southwest of Denver.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


text:
If your website
was an employee,
What would its
job description be?
At Popawheely Web Design that's where we begin to design a website that works for you. I love building websites. Whether your web site needs to provide customer support, sales, lead generation, information, entertainment, or inspiration! I have the experience, and the know how, to put together a website that has all the functionality, and design sense to achieve your objectives. Lets discuss your project.


text:
ayusitha -tuhan beri aku cinta(ost ketik...
by raudhah . 3,283 KB | 2010-09-24 | MPEG Audio Stream |
Send Ringtone to MobileRingtone
ayusitha -tuhan beri aku cinta(ost ketika cinta bertasbih) - download at 4shared. ayusitha -tuhan beri aku cinta(ost ketika cinta bertasbih) is hosted at free file sharing service 4shared.
| Uploaded via: 4shared site
Share Embed Add to my account
Is owner
View only
Upload & Edit
Members may only view items in this folder.
Members may view, add, edit and delete items in this folder.
Checked by McAfee. No virus detected.
0 comments Add new comment
Download all files from this folder
Download folder as:
This file will be created in your 4shared folder
File name:
Zip as:
What is B1?
Remove Ads x
Show QR Code


text:
(383 quotes found)
"Loyalty means nothing unless it has at its heart the absolute principle of self-sacrifice."
Woodrow T. Wilson
"Patriotism is just loyalty to friends, people, families."
Robert Santos
"Sometimes party loyalty asks too much"
John Fitzgerald Kennedy
"Loyalty to petrified opinion never yet broke a chain or freed a human soul."
Mark Twain
"If you want loyalty - get a dog. If you want loyalty and attention - get a smart dog."
Grant Fairley
"Besides pride, loyalty, discipline, heart, and mind, confidence is the key to all the locks."
Joe Paterno
"The heart loves, but moods have no loyalty. Moods should be heard but never danced to"
Hugh Prather
"Loyalty to petrified opinion never broke a chain or freed a human soul."
"Masters who sacrifice for servants will receive the gift of loyalty."
"Unless you can find some sort of loyalty, you cannot find unity and peace in your active living"
Josiah Royce
Quotes Daddy offers a number of tools for developers and bloggers to integrate quotes into their site including customizable widgets, embeddable quotes and API.
Over 1,000,000 famous quotes and user quotes that you can save to your favorites, share with friends and add to your site, blog or social network.Find us on Google Ad Planner


text:
There is no way to completely describe how beautiful Santorini is to holidaymakers. If you visit the island for a romantic honeymoon, there can be no better place. The island has different facets, including charming traditional hillside villages, the fascinating and unique sight of a volcano, stunning beaches, and limitless memorable sunsets.
Contact Us 24/7 Fill out an online request form or call our Asia Travel Specialists


text:
Peanuts by Charles Schulz
- June 04, 1970
- From Beginning
- Previous feature
- Next feature
- Current
Comments (2) (Please sign in to comment)
This is the first appearance of Thibault, a boy who played on Peppermint Patty's baseball team. This character was a little jerk. He refused to return Charlie Brown's glove to him and he said sexist remarks to Marcie.
Do not make it be, the fault of Thibault.
- Refresh Comments.
You must be signed in to make a comment.


text:
Not even surprised that the only guy who is interested in me on OkCupid has NOTHING in common with me at all.
I wanted to tell my brother something so I got up to look for him and I thought he was in the bathroom so I started knocking on the door but he didn't answer. Then the door slowly started to open and the lights were off and then I remembered that I had closed the bathroom door 20 minutes ago.
So on Okcupid I got a message from some guy asking me if when I'm in relationships do I "have sex or do sexual things". I deleted the message.
Doctor Who on Netflix was a bust. Good thing they had it on demand. Oh, and Comcast, Karen Gillan plays Amy, not Billie Piper.
So the computer I've been using has froze 3 times in the past hour. I think I'll just go curl up with my Netbook and watch Doctor Who in my room.
My cousin just bad mouthed Scott Pilgrim Vs. The World. I am saddened.


text:
amanda. 25. BA in history. supernatural. battlestar galactica. friday night lights. lord of the rings. the hobbit. avengers. thor. hemsworth. hiddles. music. drinking. good times. my lady avengers.
Catching Elephant is a theme by Andy Taylor
made these guys from a recipe that fuckingrecipes posted the other day. i melted nutella and chocolate chips and put them in a starfish ice cube tray to freeze. and they are delicious!


text:
Dr. Robert A. Lester, MD
Family Medicine, Owasa Family Medicine
- 109 Hospital Dr
Calhoun, GA 30701
- 1 Office Location
- Email a Friend
- (706) 625-0333
Dr. Robert A. Lester has been practicing medicine for 11 years. Dr. Lester graduated from the University of Arkansas College of Medicine at Little Rock in 2003. He practices medicine in Calhoun, GA and specializes in Family Medicine. Dr. Lester is affiliated with Gordon Hospital.
Gender: Male
Years in Practice: 11 Years
Languages Spoken: English
Medical School: University of Arkansas College of Medicine at Little Rock
Graduation Date: 2003
Hospital Affiliations: Gordon Hospital
Specialties: Family Medicine
©2005-2014 WebMD, LLC. All rights reserved.
WebMD does not provide medical advice, diagnosis or treatment. See additional information.


text:
- Added: 29 November, 2013
- Idol: Hana Nonoka
- Duration: 116 minutes 50 sec ( 6 scenes )
- 0%
- Add to Favorites
This DVD Movies
Featured model : Hana Nonoka
Superb Japanese hottie Hana Nonoka enjoys horny guy stimulating her hard nipples while having hardcore action at work, fucking and sucking like crazy over a fat cock during impressive fucking at the office scene. She is a kinky chick and enjoys fucking in strange places!
- 75%
- Movie size : 330 Mb
- Movie length : 8:22
Featured model : Hana Nonoka
Adorable Japanese stunner Hana Nonoka gets teased by a sexy guy in a backroom of the club. She strips and stays in a sexy lingerie, and the guy starts to tease her sweet trimmed pussy and she takes his hard stiff cock in mouth, and gets pounded in a doggystyle.
- 45%
- Movie size : 823 Mb
- Movie length : 21:26
Featured model : Hana Nonoka
Busty Japanese redhead Hana Nonoka looks arousing and sexy in her fashionable costume. Her sexy lover plays with her juicy tits and fondles her appetising ass. The excited girl makes facesitting and gets her fresh neat pussy licked well, followed by hardcore doggystyle banging and gets cum on tits.
- 85%
- Movie size : 2 Gb
- Movie length : 29:45
Featured model : Hana Nonoka
Sweet japanese milf Hana Nonoka enjoys deep fingering her wet pussy in amazingly hot solo action along her sexy vibrator which she slides gently up and down that wet vag, enjoying intense pleasure and deep sensations. She is a sexy gal and her guy is more than ready to fuck her hard.
- 62%
- Movie size : 808 Mb
- Movie length : 14:42
Featured model : Hana Nonoka
Spicy Japanese hottie Hana Nonoka looks really arousing in her office suit. She knows that she attracts her colleague, and she comes up to him and lets him play with her pretty body. The guy reveals her boobs and starts to kiss them hot, and she takes his dick in mouth. He gets really wild and fucks her in a doggystyle.
- 69%
- Movie size : 2 Gb
- Movie length : 27:38
Featured model : Hana Nonoka
Steaming Japanese AV model Hana Nonoka looks gorgeous in the costume of a maid. This sexy babe is very naughty, and she never refuses a chance to have some hardcore fun with her horny boss. She enjoys licking her boobs and gives head, performing a very skillful cock sucking action.
- 74%
- Movie size : 1015 Mb
- Movie length : 14:57
Our DVD's Archive
- 10ppl Negligence G..
- % min. sec.
- Endless Cleaning F..
- % min. sec.
- Hardcore Sex 2
- % min. sec.
- Yui Tatsumi Bomber..
- % min. sec.
- Cutie Real College..
- % min. sec.
- Riku Minato - Let&..
- % min. sec.
- YUU Vol 1 - Real S..
- % min. sec.
- Semen Nakadashi As..
- % min. sec.
- Godly Waist And Su..
- % min. sec.
- KOKESHI Vol.6: The..
- % min. sec.
- Milk Squirting Voi..
- % min. sec.


text:
'What Ever Happened to Baby Jane?' -- The book, the play, the camp
"OH, Blanche. You know we got rats in the cellar?"
That was one-time child star Baby Jane Hudson, played by Bette Davis, tormenting her wheelchair-bound sister, the well-groomed movie queen, Blanche, played by Joan Crawford, whose career was cut short by a car accident.
This is one of the innumerable great moments in the movie version of "What Ever Happened to Baby Jane."
But what many fans don't realize is that the movie is based on a book by the late Henry Farrell. It was Joan Crawford who read the book and thought it would make a fine vehicle for herself and Miss Davis. She visited Davis backstage during the controversial run of Bette's "Night of the Iguana."
(That was a production and performance Tennessee Williams hated. And Miss Davis, of course, was pleased when her "Iguana" co-star, Patrick O'Neal came to loathe her. Bette could only work in full battle mode.)
Anyway, a brand-new edition of the book has been released. It contains extras such as Farrell's biography, written by Mitch Douglas. And three of Farrell's short stories, in print for the first time.
Douglas also includes some info on the famous Davis/Crawford feud, which is always fun to read about, though I honestly believe it has been greatly exaggerated. One way or another, it is Davis who comes off much worse than Crawford. (But who can resist Bette's tale of Joan wearing iron falsies, the better to make it more difficult for Davis to lift her off the floor?)
And it should come as no surprise that there is a West End/Broadway version of "Baby Jane" in the works. It doesn't appear to be a musical. Although there are limits to what Blanche Hudson could do, being in a wheelchair. Casting? How about Vanessa Redgrave and Judi Dench?
The new edition of "Baby Jane" comes from Grand Central Publishing.
I did get a kick out of "entertainment reporter" Bill McCuddy saying that he now knows that the star Alec Baldwin "is old" because his new MSNBC show, called "Up Late," is on the air at 10 p.m. EST; 9 p.m. Central.
Nevertheless, Baldwin is compelling, whatever the hour. His heart-to-heart with the elusive and sometimes mysterious actress Debra Winger was absolutely riveting. In the first place, these two talked about acting, publicity and stardom in a charming manner. They are both self-interrupters, which makes one strain to follow them and stay on point. Because neither is run of the mill and not "into it" for any obvious reason, they keep you concentrating. They are not run-of-the-mill stars out working to be better known or to sell anything.
I just loved it. I wish Alec would talk to other actors more because, frankly, I am sick of almost every politician I have ever heard of.
This show reminds me a little of another MSNBC host, Lawrence O'Donnell, who does as he darn well pleases and has a big sense of humor. One senses he might just chuck it all right in the middle of the show.
I haven't met even half of the people MSNBC puts on beginning at 5 p.m. each day but I like sticking with this liberal network. I feel almost everyone on MSNBC could be a personal friend, even when I don't agree with them.
THE GREAT Shirley Jones, who was a sensational, beautiful star of movie musicals before she became the mullet-haired, pants-suited matriarch of TV's "The Partridge Family," is returning to the stage. She will star in playwright Josh Ravetch's new work, "The Astronomer." No word on what it's about, but public readings have been very good and Miss Jones has signed on for a full-blown production.
And in case you need reminding, Shirley Jones won a best supporting actress Oscar in 1961 for her portrayal of a hooker in "Elmer Gantry." That same year Elizabeth Taylor took best actress for her call girl role in "BUtterfield 8. I'm racking my brain trying to think if such a confluence of sluttiness ever occurred at the Oscars again?
LAST WEEK'S gripping episode of "Homeland" gave me hope that the series had regained its footing. However, the one that ran this past Sunday made me wonder if the writers had gone as crazy as Claire Danes' bipolar CIA operative Carrie Mathison? The "twist" ending of the most recent episode seemed tacked on, riddled with holes. (I won't spoil it for those who might be behind on their DVR viewing.)
Even more distracting, are the misadventures of Brody's (Damian Lewis) daughter, Dana. It's all very teenage and "Twilight," minus the fangs and super-pale make-up. The young actress, Morgan Saylor, who portrays Dana, is quite attractive and an able actress, but her plotline is totally off the radar of what the show promised to be. And viewers are almost unanimous in their distaste for Dana's story arc. Of course, critics always go too far, especially online. They write -- all in caps -- that they want the character dead! (Morgan should have a chat with Anna Gunn, who had to defend her character, and herself, in a New York Times article!)
I won't give up on "Homeland." I just hope the show hasn't given up on its original fan base.
(E-mail Liz Smith at email@example.com.)
(c)2013 TRIBUNE CONTENT AGENCY, LLC.Copyright © 2014, The Baltimore Sun


text:
News from WTOP
News from the AP
Mike Causey
Shows & Panels
- Agency of the Month
- Business of Government Hour
- The CFO Agenda: Delivering value from financial transparency and audit efforts in the public and private sector
- CXO Surveys
- Federal News Countdown
- Government Perspectives on Mobility and the Cloud
- Reducing Risk in the Cloud
- Reimagining the Next Generation of Government
Shows & Panels
- The 2014 Big Picture on Cyber Security
- AFCEA Answers
- American Readiness: Renewable Power and Efficiency Technologies
- Ask the CIO
- Building the Hybrid Cloud
- CDWG/NetApp
- Connected Government: How to Build and Procure Network Services for the Future
- Continuing Diagnostics and Mitigation: Discussion of Progress and Next Steps
- Delivering the Digital Government Mission
- Federal Executive Forum
- Federal News Radio's National Cyber Security Awareness Month Special Panel Discussion
- Federal Tech Talk
- The Future of Government Data Centers
- The Future of IT: How CIOs Can Enable the Service-Oriented Enterprise
- Government Perspectives on Mobility and the Cloud
- The Intersection: Where Technology Meets Transformation
- Maximizing ROI Through Data Center Consolidation
- Mitigating Insider Threats in Virtual & Cloud Environments
- Modern Mission Critical Series
- The New Generation of Database
- Reducing Risk in the Cloud
- Reimagining the Next Generation of Government
- Targeting Advanced Threats: Proven Methods from Detection through Remediation
- Transformative Technology: Desktop Virtualization in Government
- The Truth About IT Opex and Software Defined Networking
- Air Traffic Management Transformation Report
- Cloud First Report
- General Dynamics IT Enterprise Center
- Gov Cloud Minute
- Government in Technology Series
- Homeland Security Cybersecurity Market Report
- National Cybersecurity Awareness Month
- Technology Insights
- The Cyber Security Report
- The Next Generation Cyber Security Experts
Shows & Panels
Search Result
Search Tags: Linda Petersen
How managers can salvage training during tight budgets
One of the first victims of the budget axe is often professional training, says Linda Petersen, a former longtime Office of Personnel Management official now with Graduate School USA. Petersen, who joined In Depth with Francis Rose said too often training, which carries long-term benefits is not viewed as being part of an agency's strategic vision.
Tags: In Depth , Francis Rose , training , workforce , retention , management , best practices
Monday - 07/23/2012, 05:37pm EDTListen


text:
|30 Dec 2009
WIN7 problems with internet access in 2003 domain
Dear all,
I'm facing a real strange problem in our WIN2003 network. We are running around 15 machines with XP in out local domain where there's no problem with Internet connectivity.
Now we started to shift from XP to Windows 7 (using a new machine) but
# we can easily logon to the domain
# we can see/ping all local machines/servers including our Fortigate firewall
# and it takes us hours to get access to the outside world on the Windows 7 machine
# once we suceeded, there are "losses" many many times which causes big problems handlings mails (outlook/kerio) or web page access (Firefox,IE)
Any idea?
Thx already a lot in advance...
|My System Specs
|30 Dec 2009
W7 Ultimate 64bit W7 Premium 64bit W7 Premium 32bit WXP Home 32bit
You may want to try disabling IPV6. Some have said it can cause problems and since you're in a WS2003 domain, IPV6 isn't used anyway.
|My System Specs
|31 Dec 2009
Thx RedBirdDad - I think I did this already, but I'm not sure. I'll check this a.s.a.p because I'm not in the office today. I'll let you know. I wish all of you a happy new year
|My System Specs
|Thread Tools
|Similar help and support threads for2: WIN7 problems with internet access in 2003 domain
|Access problems after joining Windows 7 machines on W2K3 Server domain
|General Discussion
|Domain joined pc, does domain admin have access to my homegroup
|Network & Sharing
|joining a SBS 2003 domain
|Network & Sharing
|Problems after joining 2003 domain
|Network & Sharing
|Join Win 7 to 2003 Domain
|Network & Sharing
|Win7 x64 Crashes on Internet Access or File Access
|BSOD Help and Support
|SBS 2003 domain
|Network & Sharing
|Our Sites
|Site Links
|About Us
|Find Us
Windows 7 Forums is an independent web site and has not been authorized, sponsored, or otherwise approved by Microsoft Corporation. "Windows 7" and related materials are trademarks of Microsoft Corp.
© Designer Media Ltd
All times are GMT -5. The time now is 03:45 AM.


text:
"I am so happy that the the New Hampshire Retail Association has offered me and my employees the ability to purchase discounted electricity and natural gas with their Energy Purchasing Program through Resident Power. I switched my store away from my previous suppler six months ago, and we are saving almost $150 a month. I just signed up my home with Resident Power, and I gave applications to all my employees yesterday. It is wonderful to have a program that I can pass along to my staff – it's another benefit for them working for me. Just one more great reason to belong to the NH Retail Assoc!"
Dennis DiPaolo, Owner
Seasonal Specialty Stores, Amherst
Electricity and Natural Gas – The New Hampshire Retail Association has joined forces with Resident Power and Freedom Energy Logistics to offer our members guaranteed energy savings on the electric portion of their bill. Through the NH Retail Assoc's Energy Purchasing Program, you can purchase discounted electricity and natural gas for your business. But, that's not all! We also offer a residential program, so you and your employees can take advantage of this benefit and get great rates.
The New Hampshire Retail Association's Energy Purchasing Program, Making Power Affordable for our members!
Questions? Click here for the FAQ's
Click Here for a brochure for your employees
Click here for an appointment of agent form
"When you are making business decisions you must have a good confident understanding that you are making the right decision. I really needed a resource to help me through this process. Working with the New Hampshire Retail Association has truly been a great experience. The support I received from them has been way over the top."
Ken Young
Owner, Young's Restaurant
Durham, NH
"As we pass our 7th year as part of the New Hampshire Retail Association's worker's comp program, we have saved tens of thousands of dollars and could not be happier. If anyone is looking for a way to cut expenses, they should take a hard look at this program. Don't underestimate the potential savings. Not only have we saved money monthly, but at the end of the year, we have received a substantial dividend."
Dave Souter
Owner, Baron's Major Brands
Concord, Belmont, Plaistow, Salem, Manchester, Ossipee, NH
"One of the treasures that the New Hampshire Retail Association has is their affiliation with MESCA Freight Services. I didn't realize that until 2008 when we started looking at how to tackle the complex issues of shipping, receiving and the constant rise in cost. I'm amazed and pleasantly surprised at the level of service, effectiveness and quality that MESCA has provided. They are always diligent and able to answer any questions at all times. Certainly, being a member of the NH Retail Assoc is worth every penny!"
Daniel Masera
Owner, Plymouth Ski and Sport
Plymouth NH
"It is imperative that Retail have a voice at the statehouse, as other industries do. The New Hampshire Retail Association provides retail with the pathway that is necessary to communicate with our very large legislature. The NH Retail Assoc provides valuable services to its members, but also allows its members to speak out on issues of importance, and funnels those thoughts and concerns to our elected leaders. Without the NH Retail Association, each retailer would have to independently attempt to reach out to our leaders, and that would be inefficient and certainly less impactful."
Tom Zapf
Vice President Legislative and Government Affairs
"I have used the New Hampshire Retail Association's credit card processing program since the very beginning when I opened my business in 1995. I have found their program to be the best for rates, service, and consistency. Over the years I have been solicited by other services which may look good, but upon closer inspection none have offered the value that the NH Retail Association's does."
Richard Buessing
Owner, True Confections
Concord, NH