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Mode of action assay-Specificity dose response assay for the KCNQ2 activators in the KCNQ1 expressing cells by the Tl flux assay
Name: Mode of action assay-Specificity dose response assay for the KCNQ2 activators in the KCNQ1 expressing cells by the Tl flux assay ..more
Tested Compounds:
Related Experiments
Name: Mode of action assay-Specificity dose response assay for the KCNQ2 activators in the KCNQ1 expressing cells by the Tl flux assay
Data Source: Johns Hopkins Ion Channel Center (KCNQ2_KCNQ1_Act_Tl_CRC)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC)
Center Affiliation: Johns Hopkins University, School of Medicine
Screening Center PI: Min Li, Ph.D.
Assay Provider: Min Li, Ph.D.
Network: Molecular Libraries Probe Production Centers Network (MLPCN)
Grant Proposal Number: 1 R03 DA027716-01
Grant Proposal PI: Min Li, Ph.D., Johns Hopkins University School of Medicine
Assay Implementation: Haibo Yu Ph.D., Kaiping Xu M.S., Shunyou Long M.S., Meng Wu Ph.D., David Meyers Ph.D., Owen McManus Ph.D.
Voltage-gated potassium (K) channels are critical for neuronal function in excitable tissues such as brain and heart. They are also found in non-excitable tissues important for other functions such as hormone secretion, oxygen-sensing and immune responses. There are more than 100 genes in human genome encoding different but homologous potassium channels. Isolation and characterization of bioactive chemical probes could form important pharmacological foundation, providing a great deal of insights into the structure and function.
The M-type channels are unique voltage-gated and ligand-regulated K+ channels with their distinct physiological and pharmacological characteristics. They are activated at a voltage near the threshold for action potential initiation and regulate membrane excitability. The KCNQ (or also called Kv7), members of Kv channel superfamily, includes five members, KCNQ1 to KCNQ5. Among them homodimer and/or heterodimer of KCNQ2 and KCNQ3 are believed components of the M-channel. The modulators of KCNQ2 are playing an important role in the neuronal function regulation. As the therapeutic targets, the KCNQ2 openers have great potential used to treat epilepsy, pain and anxiety et al.
Principle of the assay
The purpose of the assay is to examine the non-specific effects of KCNQ2 activators on the KCNQ1 expressing cells. It employs the same experimental conditions as presented in the primary screen assay, except in multiple concentrations. Compounds were tested in triplicates and their effects were evaluated by the calculated FluxOR fluorescence ratio.
KCNQ2, KCNQ1, Thallium, Flux OR, agonist, activator, potentiator, Concentration Response Curve, JHICC, Johns Hopkins, Molecular Libraries Probe Production Centers Network, MLPCN.
Protocol for the KCNQ1 specificity screen:
1. . Cell culture: Cells are routinely cultured in DMEM/F12 medium, supplemented with 10% Fetal Bovine Serum (FBS), 50 IU/ml penicillin, 50 ug/ml streptomycin, and 500 ug/ml G418.
2. Cell plating: Add 50 ul/well of 120,000 cells/ml re-suspended in DMEM/F12 medium with 10% FBS.
3. Incubate overnight at 37C and 5% CO2.
4. Remove medium and add 25 ul /well of 1x FluxOR solution to cells.
5. Incubate 90 minutes at room temperature (RT) in darkness.
6. Prepare 7.5X compound plates and control plates on the Cybi-Well system: test compounds are prepared using assay buffer; controls are assay buffer (IC0), ICmax of ZTZ240 (all with DMSO concentrations matched to that of test compounds).
7. Remove FluxOR dye solution and add 20 ul /well of assay buffer to cells.
8. Add 4 ul of 7.5x compound stock into the cell plates via Cybi-Well system.
9. Incubate all cell plates for 20 minutes at RT in darkness.
10. Prepare 5x stimulus buffer containing 12.5 mM K2SO4 and 12.5 mM Tl2SO4.
11. Load cell plates to Hamamatsu FDSS 6000 kinetic imaging plate reader.
12. Measure fluorescence for 10 seconds at 1Hz to establish baseline.
13. Depolarize cells with 6 ul/well of stimulus buffer and continue measuring fluorescence for 110 seconds.
14. Calculate ratio readout as F(max-min)/F0.
15. Calculate the percentage of tested compounds with the following formula:
Percentage (%)=100* (Ratio(cmpd)- AvgRatio(NC))/(AvgRatio(NC)-AvgRatio(Blank))
Percentage(%): percentage change of compound readout over those of negative controls (vehicle control)
Ratio(cmpd): Ratio of the test compound.
AvgRatio(NC): Ratio average of the negative controls with stimulus buffer.
Ratio (Blank): Ratio of the blank control without stimulus buffer.
16. Outcome assignment:
If the test compound causes potentiation or inhibition effect on the KCNQ1 in any concentrations tested and the dose response is generated, the compound is considered to be active.
If the test compound does not cause potentiation or inhibition effect on the KCNQ1 in any concentrations tested or a dose response is not generated, the compound is designated as inactive.
17. Score assignment
An inactive test compound is assigned the score of 0.
An active test compound is assigned the score of 100.
List of reagents
1. CHO-KCNQ1 cell line (provided by JHICC)
2. PBS: pH7.4 (Gibco, Cat#10010)
3. Medium: DMEM/F12 50/50 (Mediatech, Cat#15-090-CV)
4. Fetal Bovine Serum (Gemini, Cat# 100-106)
5. 200 mM L-Glutamine (Gibco, Cat#25030)
6. 100x Penicillin-Streptomycin (Mediatech, Cat#30-001-CI)
7. 0.05% Trypsin-EDTA (Gibco, Cat#25300)
8. Geneticin: (Gibco, Cat#11811-031)
9. HEPES (Sigma, Cat#H4034)
10. ZTZ-240 (Synthesized)
11. FluxOR detection kit (Invitrogen, Cat #F10017): FluxOR, assay buffer and
stimulus buffer.
12. Triple-layer flask (VWR, Cat #62407-082)
13. BD Biocoat 384-well plates (BD, Cat# (35)4663 and Lot #7346273)
Possible artifacts of this assay may include, but are not limited to: unintended chemicals or dust in or under the wells of the microtiter plate, or compounds that quench or emit light or fluorescence within the well. All test compound concentrations reported are nominal; the specific concentration for a particular test compound may vary based upon the actual sample provided by the MLSMR. The condition is optimal for screening for compounds that modulate KCNQ2 potassium channels, not for the assay of the KCNQ1 modulators. The data of this set were normalized and cautions should be used for comparison with other counter screens.
Categorized Comment - additional comments and annotations
From PubChem:
Assay Cell Type: CHO
From ChEMBL:
Assay Format: Cell-based
Assay Type: Functional
Result Definitions
* Activity Concentration. ** Test Concentration.
Additional Information
Grant Number: 1 R03 DA027716-01
Data Table (Concise)


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by Linda Pittam, ASID and Carolyn Howard, ASIDIn designing this kitchen, Herb and Jan Galloway chose Dacor appliances because of the brand recognition and reputation for being high-quality products at a reasonable price. Other than their family room, everyone spends more time in the kitchen than in any other room of the home. In fact, when Jan's 3-year-old grandson comes to visit, he automatically runs for the kitchen because he knows that's where she'll most likely to be! Her favorite product is the warming drawer. If dinner is prepared, but it's not quite time to be served, she puts the food in the drawer and knows that it will be maintained at an even heat without becoming dry.Operating efficiently and quietly, Jan believes her Dacor appliances are an attractive addition to the kitchen decor.
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If you have ever felt drained or sluggish after a day in the hot sun or a tough workout, your body may be telling you that it needs more electrolytes.
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The products and claims made about specific products on this site have not been evaluated by Pharmaca.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information on this site is for educational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Pharmaca Integrative Pharmacy will not assume liability for any cross-contamination of ingredients, misprints, or adverse reactions to any ingredients in the products we carry. The products sold here may contain lead and other substances that are known to the state of California to cause cancer and birth defects and other reproductive harm. Prices and promotions are subject to change without notice. All content on this web site is copyrighted by Pharmaca Integrative Pharmacy unless otherwise stated. All online offers and prices are valid for online purchases only, and may be different from those in our retail stores. Free shipping offer may not apply to all orders and all states; see shipping policy for full details. Copyright © 2009 – 2015 by Pharmaca Integrative Pharmacy. All rights reserved.


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If anything can instantly kickstart our internal covet-o-meter, it's seeing a fabulous pair of shoes... on someone else's feet. It's funny, but true: Nothing makes a pair of killer heels or perfectly distressed moto boots as appealing as spying them on a stylish stranger. To wit, we're always scoping out the shoe scene at events, on the street, and inside local shops. But lately, we've been keeping a photog close at hand to document each stalk-worthy set of soles, too.Now, we're presenting you with the fruits of our (somewhat voyeuristic) labor — a bounty of lust-worthy footwear we spotted, and snapped, right here in Washington. Click through to see our favorite pairs (and pick out your own!).
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Interpretive Handbook
61212 :
ADAMTS13 Activity and Inhibitor Profile
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Thrombotic thrombocytopenic purpura (TTP), a rare (estimated incidence of 3.7 cases per million) and potentially fatal thrombotic microangiopathy (TMA) syndrome, is characterized by a pentad of symptoms: thrombocytopenia, microangiopathic hemolytic anemia (intravascular hemolysis and presence of peripheral blood schistocytes), neurological symptoms, fever, and renal dysfunction. The large majority of patients initially present with thrombocytopenia and peripheral blood evidence of microangiopathy, and in the absence of any other potential explanation for such findings, satisfy criteria for early initiation of plasma exchange, which is critical for patient survival. TTP may rarely be congenital (Upshaw-Shulman syndrome), but far more commonly is acquired. Acquired TTP may be considered to be primary or idiopathic (the most frequent type) or associated with distinctive clinical conditions (secondary TTP) such as medications, hematopoietic stem cell or solid organ transplantation, sepsis, and malignancy.
The isolation and characterization of an IgG autoantibody frequently found in patients with idiopathic TTP, clarified the basis of this entity and led to the isolation and characterization of a metalloprotease called ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif 13 repeats), which is the target for the IgG autoantibody, leading to a functional deficiency of ADAMTS13. ADAMTS13 cleaves the ultra high-molecular-weight multimers of von Willebrand factor (VWF) at the peptide bond Tyr1605-Met1606 to disrupt VWF-induced platelet aggregation. The IgG antibody prevents this cleavage and leads to TTP. Although the diagnosis of TTP may be confirmed with ADAMTS13 activity and inhibition studies, the decision to initiate plasma exchange should not be delayed pending results of this assay.
Useful For Suggests clinical disorders or settings where the test may be helpful
Assisting with the diagnosis of congenital or acquired thrombotic thrombocytopenic purpura
Interpretation Provides information to assist in interpretation of the test results
<10% ADAMTS13 activity is highly indicative of thrombotic thrombocytopenic purpura (TTP) in an appropriate clinical setting. The presence of ADAMTS13 inhibition (positive inhibitor screen) with a measurable antibody titer is most consistent with an acquired TTP.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
The ADAMTS13 activity assay is an in vitro assay using a synthetic substrate peptide in a static liquid environment. The measured ADAMTS13 activity may not reflect the true in vivo biological ADAMTS13 activity.
Not all patients with a clinical diagnosis of idiopathic thrombotic thrombocytopenic purpura (TTP) have a severe ADAMTS13 deficiency. Conversely, patients with other non-TTP conditions may have a severe ADAMTS13 deficiency (< or =10%). These conditions include hemolytic uremic syndrome, hematopoietic stem cell and solid organ transplantation, liver disease, disseminated intravascular coagulation, sepsis, pregnancy, and certain medication. Therefore, TTP remains a clinical diagnosis.
Interferences of ADAMTS13 activity assay include high levels of endogenous von Willebrand factor, hyperlipidemia, hemolysis with plasma free hemoglobin >2 g/L, hyperbilirubinemia (bilirubin concentration >100 micromolar), and cleavage by other protease.
Recent plasma exchange or transfusion may falsely normalize ADAMTS13 levels, thus potentially masking the diagnosis of TTP.
The impact of ADAMTS13 levels and presence of inhibitors on overall survival, ultimate clinical outcome, responsiveness to plasma exchange, and relapse are still controversial. Therefore, clinical correlation is recommended.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
> or =70%
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Sadler JE: Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood 2008 Jul 1;112(1):11-18
2. George JN: How I treat patients with thrombotic thrombocytopenic purpura: 2010. Blood 2010 Nov 18;116(20):4060-4069
3. Upshaw JD, Jr: Congenital deficiency of a factor in normal plasma that reverses microangiopathic hemolysis and thrombocytopenia. N Engl J Med 1978 Jun 15;298(24):1350-1352


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Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
With a superb location and the full range of facilities of the Spa Hotel Strass complex at your disposal, the Strass Villa is a great value choice. This annexe known as the Villa, is only 30 metres away from the main hotel. All guests staying in the annexe have meals in the Spa Hotel Strass and can enjoy all of the facilities including the fantastice spa and leisure area, live music, grill, late night eaterie and après ski 'Ice Bar'.
2 people on half board sharing a room with Austrian twin beds, private shower, WC and balcony. Single rooms also available. Junior suites are 4* standard and consist of one room with Austrian twin beds and sofa bed, available at a supplement and including 4 course evening meals.
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 020 8544 7114 for prices for other travel
and room options for this property.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


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Rechargeable LED Lantern
A lantern with 40 LEDs to fulfill all your emergency and portable lighting needs.
This rechargeable LED lantern is a portable light source with 40 LEDs that can last up to 7 hours on a full charge.
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UK: Iglo Group CEO Glenn steps down
The CEO of Iglo Group, Martin Glenn, has announced his intention to step down after six years at the helm.
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Organiser: CIMdata
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Venture Capital Blog
The P-I traces startups, venture capital and life in the Pacific Northwest technology community.
Software CEO facing charges after bison hunt
Back in May, I reported on the strange tale of Attachmate CEO Jeff Hawn who was charged with multiple counts of animal cruelty after paying hunters to kill 32 bison that had wandered onto his Colorado ranch. [Read More]
Big Fish Games hooks $83 million venture deal
Big Fish Games has reeled in the biggest venture financing deal in the state this year. [Read More]
Report: Bezos puts money behind Finsphere, Aviary
ValleyWag reports that Amazon.com founder Jeff Bezos has sunk money into Bellevue's Finsphere and New York's Aviary [Read More]
Pogue on Earth Class Mail
Following up on a review of Seattle's Earth Class Mail from earlier this month, David Pogue of The New York Times today offers exceprts from letters from readers who sent postal mail to the columnist's account with the company. [Read More]
Roundup: Ontela, Medio, PayScale, etc.
NCsoft Corp., the Korean developer of massively muliplayer online games, is establishing a new subsidiary for the U.S. and European markets that will be headquartered in Seattle. The new unit — tentatively dubbed NC West — will be led by Chris Chung, Jeff Strain, David Reid and Patrick Wyatt. Chung and Reid previously worked at Microsoft, while Strain and Wyatt previously worked at Blizzard Entertainment. [Read More]
Seattle mobile game companies merge
Seattle-area mobile gaming startups Reaxion Corp. and Mobliss Inc. are merging as they try to survive a consolidation wave in the industry caused by weak growth. [Read More]
TechCrunch50: Swype is new way to type
At a product demonstration event hosted by the MIT Venture Lab three months ago, Swype won over judges (I was among them) with a new technology that allowed mobile phone users to input text using a finger by drawing lines between letters on a keypad. [Read More]
Can Washington state displace Silicon Valley?
California's venture capital market is about 10 times bigger than Washington's, both in terms of deals and dollars. [Read More]


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Measurement and Modeling of Healthy Food and Activity Landscapes
The primary aims of the research project are to use and adopt novel methods to measure and model access to healthy foods and activity environments in an urban area and to engage community members in developing a demonstration project of policy and environmental change to increase access to healthy foods and improved activity environments.
Secondary aims include:
- Use a mixed-methods approach to assess residents' shopping and physical activity patterns and reported barriers and facilitators to healthy food access and physical activity
- Create a spatial model of healthy food availability using a valid and reliable observational measure of food environments
- Apply cartographic modeling (raster GIS analysis) in novel ways to create healthy food and physical activity "landscapes"
- To work with community members to design and evaluate a pilot intervention to address barriers to healthy food access and physical activity in two neighborhoods in urban Philadelphia
We will also complete development of and conduct an advanced training institute to prepare young investigators and early-career practitioners to use both observational and self-report measures of nutrition and activity environments and related behavioral assessments. The Advanced Built Environment Assessment Training (BEAT-Plus) Institute will add online instruction and train-the-trainer techniques to previously developed classroom training, computer labs, field work, and participatory methods.
Funded by the United States Department of Agriculture


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No doubt, nail art is seriously having a moment. But we're already at a point where certain patterns have become passé (accent finger anyone?). To keep your tips covered in fresh, fantastic looks, we've compiled Nail Art's New Wave, a collection of our favorite new patterns inspired by super-talented manicurist Julie Kandalec and Maybelline New York's Color Show Nail Lacquer – plus hints on how to execute them perfectly.
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The 2011 Formula 1™ Qantas Australian Grand Prix is auctioning off the once-in-a-lifetime experience to ride in a two-seater F1 race car to raise funds to support Queensland flood victims.
The eBay-based auction begins on Monday 17 January and ends on Friday 28 January 2011.
The winning bidder will experience the speed and g-forces of an F1 race car while strapped in the rear seat for a hot lap around the spectacular Albert Park street circuit during this year's event.
"To experience the power of a two-seater F1 hitting speeds of 300 kilometres per hour is normally a money-can't-buy opportunity, so by auctioning this amazing experience we hope to raise a significant amount to support Queenslanders", said Andrew Westacott, Acting Chief Executive Officer of the Australian Grand Prix Corporation.
Former Australian F1 World Champion and Queensland resident Alan Jones agreed, "This is a fantastic initiative and hopefully motorsport fans show their support in contributing to such a crucial cause".
The two-seater is powered by a 700bhp-plus V10 racing engine and features a similar chassis construction, suspension, brakes and tyres as the cars competing in this year's championship.
The auction has now ended.


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|News » Archives
From the Pitch: With Tori and Sam Week 7
Thursday, September 30, 2010
JOHNSON CITY, Tenn. (Sept. 30, 2010) - ETSU women's soccer players Tori Head (Kingsport, Tenn.) and Samantha Kron (Paradise Valley, Ariz.) will be stopping by throughout the season to provide a weekly blog on life as an ETSU women's soccer player. Here is week seven of From the Pitch featuring Tori Head.
September 30, 2010
It has been another long week for the ETSU women's soccer team. We have all been stressed with classes and soccer. These are weeks where classes get tough, and tests start to pour in. We have kept the same schedule with soccer having practice and weights and meeting with our mental coach. We've had a couple of team bonding activities this week. In the first one we did, we all met and went to the Men's soccer game together. It's always good for us to support them and then see the support we get back from them as our teams are very close with one another. The second thing we did as a team was that we went to Fellowship of Christian Athletes (FCA). I was the speaker that night, and my teammates who wanted to come and support me that were able to come were there. It was a great experience for us. Not only was the week long but we had a lot more to worry about than school� it was our first conference weekend.
Friday was GAME DAY, ETSU versus Lipscomb University. It was our second conference game of the year. We had our pre-game meal as usual and then it was time to head to the locker room to get pumped up. There are a lot of things that go in the locker room before games that just stays between a team� but I will say Jessica Huntington and Caitlin Gaughan's dancing always gets everyone ready right before Coach walks in to give us our pre-game talk. Then it was game time. We came out with a 2-0 win! It felt so good to walk off the field with yet another conference win under our belt, but we knew we had a tough game to get ready for with Belmont. Saturday we had practice at 11:00 a.m., and it was a good day of rest for us all. We knew come Sunday we were going to have to be mentally and physically ready for the game against Belmont. Before we knew it Sunday arrived and it was GAME DAY. We had our pre-game meal at 10:30 a.m., and then we did like always heading to the locker room to get ready. It had rained all night and was still raining, so we knew it was about to be a muddy war. We had a hard fight against Belmont� They scored� we scored� we scored� they scored. It was a battle till the end. We went into double overtime. We did not come out on top this time around. We had a hard weekend, but we are not dwelling on the loss, rather we are looking forward to the weekend we have ahead of us. We leave Thursday at 11:00 a.m. for the University of North Florida. This weekend we will be playing two more conference teams, UNF and JU. Wish us luck as we travel to Florida! GO BUCS!
Until next time,
Tori Head #11
For more information on the ETSU women's soccer team, please visit www.ETSUBucs.com. Also you can follow daily post and updates on the official ETSU women's soccer Twitter page at www.twitter.com/ETSUSoccer.


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Irwin lands first recruit for 2011
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Wednesday, November 17, 2010
JOHNSON CITY, Tenn. (Nov. 17, 2010)
- Head ETSU softball coach
Brad Irwin
announced Wednesday morning that
Mariam Wood
(Soddy Daisy, Tenn.) has signed her national letter of intent to play for the Bucs starting in 2011.
"I am excited to have Mariam join our Buccaneer softball program and I am proud to have a player of her caliber as my first signee at ETSU," said Irwin. "She comes from an outstanding high school program where she has excelled both on the field and in the classroom. Miriam plays for a great and legendary coach in Clifford Kirk, so she definitely knows how to play the game and how to win. She also comes from a solid travel team as she plays for the Frost Falcons."
Winning was a strong suit for Wood and the Soddy Daisy softball team in 2010 after she helped guide the Trojans to a 52-2 record en route to capturing the Class AAA State Championship. In addition, Soddy Daisy was ranked in the top five in two national polls - including a fourth-place showing by ESPN Rise.
During the championship year, Wood hit an astounding .427 with three home runs, 10 doubles and 49 RBI. In addition, Wood was named Second Team Best of Preps and Team MVP as a junior. As a sophomore, the Soddy Daisy, Tenn. product hit .369 at the plate.
"Mariam is strong asset at Soddy Daisy as she has played several positions for coach Kirk, and I really like her versatility," added Irwin. "We look forward to using her primarily at first and third when she arrives at ETSU, but we know we have other options with her if they become needed."
Wood is a hard-working student-athlete and she plans to enter ETSU's biology/pre-pharmacy program in the fall of 2011.
For more information on Buccaneer softball, visit
Copyright ©2015 East Tennessee State Athletics. All Rights Reserved.


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Home > Electronics > Travel Electronics > Electronic Language Translators > Lingo eTERPRETER - Text to Text 12 Language Translator
Lingo eTERPRETER - Text to Text 12 Language Translator
Input your own words or phrase to be translated – up to 1000 characters - and instantly see the translation in 12 different languages
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Lingo eTERPRETER - Text to Text 12 Language Translator
Lingo eTERPRETER - Text to Text 12 Language Translator
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For more than 75 years, Ahlbin Rehabilitation Centers at Bridgeport Hospital has been at the forefront of rehabilitation in Fairfield County. Our primary goal is to help you regain maximum independence and functioning so you can return to your everyday life.
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text: Do you have an interesting idea that will grab public and media attention? Do you want to change the way that people think about diabetes? Are you lobbying your local or national government to improve diabetes care and prevention? Are you helping to implement change that will improve care for people with and at risk of diabetes? You could be eligible to become a World Diabetes Day champion. Find out how you can become a World Diabetes Day Champion.


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We all know it when we see it. The piece that's so much more than just a functional object. It's truly a work of art. What makes some objects so distinct from the everyday items that we take for granted?
It's the artisans behind the work – dedicated craftsmen and -women who have a passion for beauty, form, and function and the unique ability to balance and meld these into exquisite works of art that stand the test of time.
chris williams
Knife Maker
Five years ago, Chris Williams was a member of a successful wealth management firm, but his off-hours were spent "hobbying around" with knife making. "Money management was fun, but making knives is way more fun," he said.
Williams sold his first knife to a buddy who bought it for $20 when the two were shrimping together. Now his knives fetch upward of $300, and he has made more than 2,000 of them. Today his company, Williams Knife, employs two full-time workers. The company is based in Johns Island, South Carolina.
Each knife is custom made and takes at least 60 hours to create. Wait time for a knife can run anywhere from a few months to a full year. This labor-intensive process is a labor of love for Williams.
"I like every part of it from sourcing exotic woods to finding local bones for the inlay to curing the wood to honing the edge to hand sanding the piece," he related. "Sometimes people say my knives are too pretty to use, but making them pretty is the easy part. Making them useful is what takes the work." For instance, it took Williams 14 years to master the proper engineering of an oyster knife.
Most of the company's product line is dedicated to fishing and hunting, but Williams is always looking for new challenges. Recently, he trailed chefs in Charleston, the culinary capital of the South, to learn how they used their knives so he could develop a chef's line. It proved popular enough to spur a home cooking line of knives that recently debuted.
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Williams understands the demand for his work. "When I buy things myself, I do tons of research because I want to buy something of quality that also has a person and a story behind it," he said.
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Strapped for operating funds due to sequestration, yet charged with providing ready forces to support the U.S. rebalance to the Asia-Pacific region, the I Corps commander said he is channeling the resources he has where it matters most: into training junior troops and developing future leaders.
Sequestration has hit I Corps "pretty significantly," Army Lt. Gen. Robert B. Brown told American Forces Press Service during a telephone interview Dec. 10.
The impact on readiness has been immediate, he noted. All 14 Army brigades at Joint Base Lewis-McChord, Wash., maintained the top readiness level for more than a decade to support regular combat rotations in Iraq and Afghanistan.
"Now there are only two," Brown lamented. "The rest are at the lowest readiness level" – referred to as "C4" on the Department of Defense Readiness Reporting System scale. "That was all they were funded for."
The deep budget cuts mandated by sequestration have slashed many of the elements that factor into readiness: education and training and equipment maintenance, among them.
"We don't have the money for the full maintenance we need," Brown said. "We don't have the money to run the full training and ranges we need."
Like a car that doesn't get its scheduled oil changes and other maintenance, the cost typically ends up higher in the end, he noted. "You can piece it together, but eventually it is going to be a big bill," he said. "That really bothers me."
Meanwhile, Brown said, the last thing he wants is having troops sitting around bored and wondering why they joined the Army. "That is my No. 1 worry and what keeps me up at night: keeping them motivated and trained," he said.
Despite budget challenges, he said, he's doing everything in his power to provide the best possible training and leadership development for his troops.
"We have tremendous leaders who are trained and developed to be agile and adaptive. They can overcome anything," he said. "So leader development remains our No. 1 priority. We have found ways to do that cheaper and are getting after that like crazy."
I Corps is maximizing simulation to provide lower-cost "virtual" training experiences, particularly for battalion, brigade, division and corps-level staff members. "They are doing almost all simulation, which is about as cheap as I can do things to keep them trained," Brown said.
"Whatever money I have is going to the lowest level," he said. "The squad, the platoon and company [levels] get out there and train. They may be required at some points to park their vehicles and walk, but they are still training hard.
"It may not be as good as it used to be, but they are still training," he said. "And that is my No. 1 focus."
Because the Army has identified I Corps to be regionally aligned toward the Asia-Pacific to support the U.S. rebalance there, Brown's exercise program has continued relatively unaffected.
"We are fortunate in that case," he said, noting that other combatant commands have had to downsize or cancel military exercises due to sequestration.
Getting the opportunity to exercise with allies and partners in the region is a tremendous troop motivator, the general said. "They are very excited. … They joined the Army to go and see the world, work with other cultures and learn from others," he said. "So it is neat to see that. They are very, very excited."
Even so, I Corps is taking pains to keep the cost of its exercises as low as possible. For the bilateral Yama Sakura exercise underway in Japan, for example, only 1,000 of the 1,500 U.S. participants actually deployed to Japan. The others reported to simulation centers at Joint Base Lewis-McChord and in Hawaii and South Korea, using simulators and video-teleconferencing to replicate the real, on-the-ground experience.
The impact of sequestration goes beyond the actual force to include those who support them, Brown said. He noted, for example, civilian staff losses at that Madigan Army Medical Center, which serves the Joint Base Lewis-McChord community.
"This is a world-class facility," which employs about 3,000 civilian employees, he said. "But a lot of those civilians were fed up with the government shutdown and sequestration and quit to go to civilian hospitals, where they don't have to worry about being furloughed."
Sequestration has had other impacts at the installation. Among them, it sidelined plans the Army and Air Force Exchange Service was making to build a new shopping complex and has limited base maintenance for all but the most essential projects.
"So it has been a huge impact, all around," Brown said.
Despite the challenges, "we are making it work," he said. "But I have to tell you, this is the toughest I have seen it in 32 years [of military service]."


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Erykah Badu Gets Naked in Flaming Lips' 'The First Time Ever I Saw Your Face' Video
After Erykah Badu joined forces with rockers the Flaming Lips for their all-collaborations album, The Flaming Lips and Heavy Fwends, it's no surprise that their union would make major headlines. They recorded a cover of an old folk song titled "The First Time Ever I Saw Your Face" -- Roberta Flack also famously sang a version of the track. Now the accompanying visuals for the song could very


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With these nine specially gimmicked cards, you can easily perform seven amazing card tricks- plus many more! You'll get instructions for Two Card Monte, Flim Flam Cards, Mind Reading Card, Transposing Cards, Flipper, Detective Joker, and even 3-Card Monte!
These special cards can be used in many different effects in addition to the seven you'll learn in the instructions. For ideas on how to use gimmicked cards, consult the Royal Road To Card Magic book or DVD.
BONUS #1! You'll also get instructions for two different and easy ways to force a card!BONUS #2! You'll also get instructions for Mental Telepathy, an incredible effect you can perform using ordinary cards!


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With the daylight hours waning and the nights getting cooler, my favorite season is approaching. There's nothing quite like autumn. The air is refreshing, the sky is deep blue, and Mother Nature puts on a breath-taking spectacle of vibrant foliage. I think the best thing about the season is the wonderful smell of fresh-picked apples, pumpkins, and the aromas of baked goods made from the harvest.
The heavenly fragrances of crisp McIntosh Apples, Pumpkin Soufflé, Amish Harvest, and many other mouthwatering combinations are just a few of the best-selling varieties of CT River soy candles I stock in my store. Naturally, it's the fragrances that sell the candles; however, it's the unique benefits of soy wax that make them increasingly popular…
Health Benefits
According to air quality experts, traditional paraffin candles contain eleven carcinogenic compounds! These toxins, similar to those found in second hand cigarette smoke, are caused by petroleum by-products and chemicals that are used to produce paraffin wax. CT River's scented soy candles are handcrafted with wax made from organic soy beans. Burning soy candles does not emit dangerous toxins, making them a healthier choice.
Environmental Benefits
By using soy candles instead of the paraffin wax variety, you are selecting a much more environmentally conscious product. Organic soy beans are a renewable resource, and the wax in soy candles is completely biodegradable, leaving a lower carbon footprint than paraffin.
Economic Benefits
Soy candles have been proven to burn cleaner and last longer. This means no messy soot build-up on walls or ceilings. Plus, a longer lasting candle does not need to be replaced as often, saving you money in the long run.
I'll admit my wife and I are recent converts to soy wax candles. I wish we were more aware of them a few years back when our region experienced a devastating ice storm that took down utility lines and left us without power for two weeks in December.
We burned lots of candles during those cold dark evenings, and when it came time for spring cleaning we were surprised by how much black residue there was on everything in the house. Now we only burn soy wax candles, and we've convinced friends and family to make the switch as well.
As I mentioned, my customers are attracted to CT River soy candles for their rich (but never overpowering) fragrances, and the advantages of soy wax candles more than justify their price. I always give people who are trying these candles for the first time a few pointers to get the most enjoyment from their CT River candles…
For maximum burn time over the life of the candle, each time you light it let it burn for one hour per inch of candle diameter. This melts the wax all the way across the top of the candle, allowing the wax to burn down evenly and avoid build-up on the inside of the jar. For longer burn times, extinguish after four hours and relight once the wax has solidified.
If the wax is not burning down evenly, after blowing out the flame simply scrape the excess softened wax on the inside of jar with a utensil and push it into the liquefied pool of wax. Keeping the wick trimmed to ¼-inch maintains an optimum flame that burns the wax more efficiently and minimizes any smoke. Always trim the wick before lighting so you can remove the foreign from the pure soy wax.
As with all candles, be sure to follow all safe-burning practices and never leave a lit candle unattended. Besides, why would you not want to be close by to enjoy the wonderful aroma and flickering flame of a CT River soy candle?
Jim Therriault
Founder and Proprietor, New England Everyday Goods & Farm Market [12], Jaffrey, NH.
Just a stone's throw down the road from The Old Farmer's Almanac headquarters, Jim and his wife Susan operate a sprawling retail store that specializes in useful and unusual products with interesting stories behind them.
- Blogs [13]
- Marketplace [14]


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text: Lali Pawa handles event planning and promotions, the press, outreach and networking, and other activities associated with SikhRI's Canadian chapter including managing the operations of the Sojhi School. She also works as a Legal Educator and Program Coordinator for the Justice Education Society and is a dance and fitness instructor for the City of Surrey. She has extensive experience as an event coordinator for many not-for-profit organizations. Lali lives in Surrey with her husband and two wonderful children.


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Katherine Jenkins (born 29 June 1980) is a Welsh mezzo-soprano. She is a classical-popular crossover singer who performs across a spectrum of operatic arias, popular songs, musical theatre and hymns.
This area is intended for discussion only. If you have a question about your order, or require customer service you can get in touch via our Customer Service Area. Comments enquiring about existing orders, including personal details, or with questions will be deleted.


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User Tip: If you're unsure of your vehicle type, you may skip the machine type selection box.
Select type, make, model and year above
"Customer service is priority #1 at Rocky Mountain ATV/MC. We value our customers and strive to be the best shopping experience- when you buy from us, you are buying lifetime service."
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We will stand behind all products we sell with regards to manufacturing defects in workmanship and material. Most products are limited to the manufacturer's warranty. However, we will do everything in our power to take care of the problem.
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Comments On Jan 16, 2014:Excellent quality and the fit was spot on. Grate product.
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Comments On Jun 05, 2013:Ordered new oil seals to replace a blown left seal on my Husky. Next time I'll only change the one that leaks. After replacing both seals, the left seal (the one that was leaking) worked great. The right leg is now leaking with the new seal. Will order OEM Marzocchi seals from now on and stay away from the aftermarket stuff.
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Comments On Apr 29, 2013:Replaced my fork and dust seals a couple years ago. No issues so far.
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Comments On Jun 01, 2012:These were a direct replacement for OEM right down to the brand and part number (both are NOK DCY 45 58 11). Dust seals didn't fit though.
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Comments On May 15, 2012:No leaks
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Comments On Feb 28, 2012:Origionally bought the tusk seals, these lasted about half a year. I thought ill buy something better quality so bought the race tech seals with lasted about 5 rides. Very dissapointed
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Comments On Jul 25, 2011:I've done the seals on 98YZ250 and 09 YZ450F and wouldn't use another brand. No Leaks, very quality product.
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Comments On May 16, 2011:OEM quality at a great prices and once again unbeatable service from RM-ATV!!!!
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Comments On May 01, 2011:function,fit,price. perfect.
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Comments On Apr 18, 2011:very good product but very expensive, used other seals at less cost and were just as good
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|News » Archives
Dahbi advances to singles flight final at Clemson
Saturday, October 05, 2013
CLEMSON, S.C. (Oct. 5, 2013) - Salma Dahbi paced the ETSU women's tennis team Saturday at the Duckworth Fall College Classic in Clemson, S.C., advancing to a singles flight title match.
Dahbi was tested in the first round of the No. 7 singles flight, dropping the opening set to Kennesaw State's Blaire LaSure, 6-1. However, Dahbi battled back, taking the second set, 6-0, before winning a third-set tie-break, 10-4, to advance to the flight semifinals.
In the semifinals, Dahbi dropped just four total games to Jill Lewis of UNC-Asheville, winning, 6-3, 6-1.
Dahbi will take on Charleston Southern's Alia Nour Sunday in the final round.
In other singles action for the Bucs, Lyn Yee Choo was edged in a third-set tie-break, 5-7, 6-3, 10-8, by Clemson's Tristan Dewar. Anna Gerbasi was eliminated in the opening round of her respective flight, while Sofia Espana advanced to the second round before being eliminated.


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Felix Frankfurter
Felix Frankfurter was born in Vienna, Austria. He emigrated with his parents in 1894 and grew up amidst teeming tenements on New York's lower east side. He attended City College and established an impressive record at Harvard Law School. He had a brief tour in private legal practice but soon entered into government service, beginning with the U.S. Attorney's office in Manhattan. Frankfurter followed the incumbent U.S. Attorney, Henry Stimson, back into private practice and then back to government, this time as Stimpson held the position of Secretary of War under President Taft.
Frankfurter left government service to accept a position on the faculty of Harvard Law School where he remained, more or less, until his appointment to the Supreme Court in 1938. Frankfurter earned a reputation as an expert in constitutional law and federal jurisdiction. But he was no academic recluse. He argued cases for the National Consumers League, maintained an active interest in Zionist causes, and helped to found The New Republic. Frankfurter was also a highly visible defender of Sacco and Vanzetti, who were anarchists accused of bank robbery and murder in Braintree, Massachusetts.
Frankfurter was a confidant of Justices Louis Brandeis and Oliver Wendell Holmes. Frankfurter would regularly scout out law clerks for these justices from among his minions at Harvard Law School. Frankfurter was also an adviser to Franklin D. Roosevelt and sent many of his students to work in the New Deal.
Frankfurter was a prolific writer on and off the Court. He wrote often even when he was not the Court's main voice. He was an epistolarian in an age where letter-writing was on the wane. He had a brisk and energetic style to all that he did. To this day, his opinions stand out in relation to his colleagues' colorless prose.
|Law School
|Terms Clerked
|William Thaddeus Coleman
|Harvard (1946)
|Vincent L. McKusick
|Harvard (1950)
|Stanley M. Silverberg
|Richard N. Goodwin
|Harvard (1958)
|Philip L. Graham
|Harvard (1939)
|Philip Kurland
|Harvard (1944)
|Philip Elman
|Harvard (1939)
|1941, 1942
|Paul Bender
|Harvard (1957)
|Louis Henkin
|Harvard (1940)
|Joseph L. Rauh, Jr.
|Harvard (1935)
|John D. French
|Harvard (1960)
|Jerome A. Cohen
|Yale (1955)
|James Vorenberg
|Harvard (1951)
|Irving J. Helman
|Harvard (1942)
|Hugh Calkins
|Harvard (1949)


text: Nile is originally from Baltimore, MD. He received a B.A. in dance from Connecticut College in 2004, where he was fortunate enough to have the guidance of wonderful dancers and teachers such as Dan Wagoner, Lan Lan Wang, Jeff Rebudal, Robyne Watkin and Jeremy Nelson. Connecticut is also where his love for Indian culture began and in 2002, Nile traveled to India to study temple and architecture studies and Bharatanatyam dance. Since moving to New York in 2004, Nile has danced with Silver-Brown Dance, LeeSaar The Company, Luis Lara Malvacias, Stefanie Nelson Dance Group and Naganuma Dance. He will forever thank his friends, family and mother, Sharon, for their love and support. He blissfully joined the Pilobolus touring company in August 2009.


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© 2012 Hans
Pagoda at Kita-in Temple
22 Aug This entry was written by Hans, posted on August 22, 2012 at 05:00, filed under architecture and tagged buddhist, camera: pentax 645nii, film: fuji acros, japan, kawagoe, year: 2012. Bookmark the permalink. Follow any comments here with the RSS feed for this post. Post a comment or leave a trackback: Trackback URL. View EXIF Data
Older: Les parapluies de Cherbourg
Outside of Kita-in temple, Kawagoe
Newer: Man soaking in atmosphere at the Edo Castle remnants, Kita-in temple
An elderly man sitting on the Edo Castle remnants that had been moved from Edo (nowadays Tokyo) to Kawagoe and that are now the only …


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David Hansen
Professional Background
Educational Background
David Hansen received his Bachelor
of Arts in the history of ideas from the University of Chicago, his
Master of Arts in political economy from Stanford University, and his
Ph.D. in education from the University of Chicago. Before taking
up his current appointment at Teachers College in 2001, he was professor
in the College of Education at the University of Illinois at Chicago,
and before that a secondary school teacher and instructor in a language
arts program for teachers.
Scholarly Interests
Professor Hansen's scholarship has focused on the philosophy and practice of teaching and of teacher education, on moral and ethical dimensions of education, on the nature of values and inquiry, and related themes. He draws from thinkers across the diverse fields featured in the Philosophy and Education program, including ethics, philosophical anthropology, and foundations of education. He has studied extensively the educational thought of figures such as Plato and John Dewey. In recent years he has focused on the relations between cosmopolitanism as an outlook on the human condition and the practice of education. He is a Past-President of the John Dewey Society and of the Philosophy of Education Society.
Selected Publications
London and New York: Routledge, 2011.
* John Dewey and Our Educational Prospect: A Critical Engagement with
Dewey's Democracy and Education. Albany: State University of New York
Press, 2006.
* Exploring the Moral Heart of Teaching: Toward a Teacher's Creed.
New York: Teachers College Press, 2001. Translated and published
(2002) as Explorando el corazon moral de la ensenanza. Barcelona:
Idea Universitaria-Educacion.
* The Call to Teach. New York: Teachers College Press, 1995.
Translated and published (2001) as Llamados a ensenar. Barcelona: Idea
honors and awards
Named a Fellow of the American Educational Research Association, 2011
Named Honorary Professor at Xiamen University, Xiamen, China, 2009
Outstanding Achievement Award, The John Dewey Society, "for contributions reflecting and extending the spirit and vision of Dewey's work," 2007
Elected President, The Philosophy of Education Society, for 2008-2009
Choice Outstanding Academic Title, 2007, for John Dewey and Our Educational Prospect: A Critical Engagement with Dewey's Democracy and Education (Albany: State University of New York Press, 2006)
James and Helen Merritt Distinguished Service Award for Contributions to the Philosophy of Education, 2006
Elected to the Board of Directors, National Society for the Study of Education, 2005
Elected President, The John Dewey Society, for 2003-2005
Outstanding Book, 2002, Division B (Curriculum Studies) of the American Educational Research Association, for Exploring the Moral Heart of Teaching: Toward a Teacher's Creed (New York: Teachers College Press, 2001)
Selected by the University of Illinois as a University Scholar, 1996
Critics Choice, American Educational Studies Association, 1996, for The Call to Teach (New York: Teachers College Press, 1995)
Selected by the National Academy of Education as a Spencer Postdoctoral Fellow, 1992
A&HF 4190: American philosophies of education
Major American thinkers and outlooks and their impact on education: Thoreau, Emerson, Fuller, and transcendentalism; Pierce, James, Dewey, and pragmatism; Douglass, Du Bois, and African-American education; Anthony, Stanton, Addams, and feminism.
A&HF 4196: Identity and ideals: Visions of human flourishing
An introduction to influential philosophical perspectives on what it means to be a successful, whole, and flourishing human being. Attention to issues of personal identity and personal ideals and how these can evolve over time.
A&HF 4900: Independent study in philosophy and education
Permission of instructor required.
A&HF 5090: The philosophy of John Dewey
For all doctoral students; master's students by permission of instructor. An analysis of the principal educational works of John Dewey.
A&HF 5093: Ways of knowing
For doctoral students, especially in Philosophy and Education; masters students by permission. Readings in epistemology in the context of teaching, learning, and educational research, from classical and enlightenment sources to feminist, hermeneutic, psychoanalytic, and postmodern critiques. Topics include objectivity and subjectivity and problems of interpretation in the arts, humanities, and natural and social sciences.
A&HF 5591: Educational debates in philosophical perspective
For all doctoral students; master's students by permission. Topics vary. Convened to promote philosophical discussion of a contemporary educational issue (e.g., patriotism, privatization, standards, technology) or ongoing debate (e.g., liberal education, moral education, standardization).
A&HF 5600: Colloquium in philosophy and education
For majors only. A series of formal presentations and discussions with scholars in the field of Philosophy and Education. Offered every fall and spring semester. Special fee: $55.
A&HF 6100: Doctoral proseminar: Modern philosophy and education
Permission of instructor required. For first- and second-year doctoral students in Philosophy and Education. Close reading and discussion of primary texts in modern philosophy that have shaped the field of philosophy of education. Complements A&HF 6000.
A&HF 6500: Dissertation proposal workshop in philosophy and education
Permission of instructor required. Prerequisites: A&HF 6000 and A&HF 6100. An ongoing writing workshop required of all doctoral students after completion of the Proseminar sequence. Students develop research interests, hone philosophical skills, and draft dissertation proposals. Offered every Fall and Spring semester.
A&HF 6590: Advanced seminar in philosophy and education
For doctoral students in Philosophy and Education or by permission of instructor. Topics vary and may range from close reading of a single text to exploration of a key concept or problematic. Past topics include contemporary theories of democratic education, cosmopolitanism and education, and conceptions of teacher education.
A&HF 6900: Advanced research in philosophy and education
Permission of instructor required. For doctoral students in Philosophy and Education only.
A&HF 7500: Dissertation seminar in philosophy and education
Permission of instructor required. Required of doctoral students in the semester following successful completion of the doctoral certification process or in the semester in which the student defends the dissertation proposal, whichever comes first.
A&HF 8900: Dissertation advisement in philosophy and education
Permission of instructor required. Individual advisement on doctoral dissertations. For requirements, see section in catalog on Continuous Registration for Ed.D./Ph.D. degrees. Fee to equal 3 points at current tuition rate for each term.
Centers and Projects
Website: http://www.klingenstein.org
Full-year and Two-Summer master's programs, MA/MBA dual degrees and funded fellowships in leadership development for independent and international school educators. Programs serve early career teachers, mid-career administrators and heads of schools from a broad range of schools around the world. All Klingenstein Center programs focus on instructional leadership, collaboration and teamwork, a commitment to social justice and diversity, ethical behavior and reflective practice.


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Some product exclusions may apply. See product page details for more information. Clearance items are final sale. Price matching does not apply to this or any promotion. Offer is valid until September 13 at 11:59 PM PST. May not be combined with any other offer/discount (unless specified), including invitation credits, promotional gift cards and/or special discount links. Discount applied upon checkout. Log in to your account to see your savings.
Whether you're a beer nerd, design buff, or both, this Pendant Floor Lamp from Peared Creation will tickle your fancy. Its diffuser consists of a pre-prohibition era beer bottle, which has been sandblasted on the inside to facilitate a warm, inviting glow. The piece attaches to an iron pipe base with industrial-style couplings, and switches on with a twist of its vintage faucet handle. Want to know more about the vessel's origins? Each fixture includes a tag that details the history of the brewery it came from, and web links for further investigation.
Cloth-wrapped 72" cord. Includes standard and replacement lightbulb. This product is crafted from repurposed vintage materials; bottle, cord color, and faucet handle will vary from image shown.
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First Sunday monthly
8:30 am
All Sundays
9:45 am &
11:15 am
Nurture Classes
for pre-K through 12th grade
Nursery open from 9:30 am-12:30 pm
is a vital and creative community of faith that welcomes all
people. We offer an inclusive,
joyful, loving, and supportive environment for all those who
choose to join us.
The place God calls
you is the place
where your deep gladness and
the world's deep
hunger meet.
—Frederick Buechner
At our Sunday Celebrations we express our faith through music, dance, poetry, evocative messages,
and fellowship at our spiritual home on Wall Street in downtown Asheville, NC.
And we also express it
by sharing ourselves and our resources with other men, women, and children and with other organizations
that serve our fellow humans, other living entities, and the Earth itself.
Jubilee Community Directory
The Directory is now available in PDF format. Click here to download it. If you have any questions or corrections email them to firstname.lastname@example.com or call Greg Walker @ 828-778-8566. Thank you.


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JOVA Construction's approach is unique: it aims to build a long-term relationship with its clientele. Maintaining your home is essential to preserve its value and we work with you to assist you with your projects in order to make your dreams your reality.Posted in Web Design → Misc
A fully responsive eCommerce website for fashion label Ruver Clothing.James VincentPosted in Web Design → Misc
Design for our new SAAS service. Impress provides you with an easy solution to create and maintain your one page website. Use Impress to showcase your work in minutes without any technical knowledge.Vincent BakkerPosted in Web Design → Software
PegsWeb is a web design company in Egypt. While designing our website, we have considered conversion optimization, an attractive color scheme and smooth transitions.Mikhaeel AzizPosted in Web Design → Design
Volta is a clean and modern Photography Wordpress Theme that is perfect to promote your photo gallery in a very professional and pleasant way. It is fully responsive; it looks stunning on all types of screens and devices (desktop, notebook, tablet and mobile).Icesoft ThemesPosted in Web Design → Photography
Sharp & Savory is a lifestyle blog run by two Toronto Designers who have an appetite to explore fashion, food and travel. This fully responsive website was branded, designed and coded from scratch by designer Charlotte Tang. Photography is by Gajan Vamatheva and Charlotte Tang.Charlotte TangPosted in Web Design → Blog
This is my personal portfolio it showcases my web design, development and art. It is a responsive design with a horizontal sliding motion, ecommerce area, blog and full social integration.Anna GreenPosted in Web Design → Portfolio
Grover is fully responsive, one-page parallax HTML5 template. It's easy to customize and comes with 4 different styles. It can be used for either personal or business projects.Themify CloudPosted in Web Design → Portfolio
Online portfolio for Mirko Humbert, a graphic and web designer from Fribourg, Switzerland.James VincentPosted in Web Design → Portfolio
Website for Kansas City restaurant, The American.James VincentPosted in Web Design → Food
JANUX is a responsive and multipurpose admin and frontend theme powered with Twitter Bootstrap 3.1 Framework.Themify CloudPosted in Web Design → Corporate
A simple responsive single page site featuring some pure css image sliders.Dean Oakley - ThrivePosted in Web Design → Misc
Website about responsive web design, a web design approach aimed at crafting sites to provide an optimal viewing experience across a wide range of devices.Lluís VilasecaPosted in Web Design → Design
A beautiful illustrated portfolio website dedicated to art direction, UX/UI, and motion design.Adrien MangournetPosted in Web Design → Portfolio
Pervolo is a nearshore IT outsourcing company. Our main goal is to offer high quality and effective end-to-end IT and business support.Marina BilanPosted in Web Design → Corporate
An intuitive site for a web development agency.James VincentPosted in Web Design → Portfolio
This is the portfolio of Adam Santoro, a French web designer and developer. I make internet stuff for people and it makes me happy.Adam SantoroPosted in Web Design → Portfolio
Tribe is an interactive design and marketing agency specializing in e-commerce and helping online retailers grow.James VincentPosted in Web Design → Corporate
Absolute is a clean, sophisticated, lightweight and adaptable business or portfolio Joomla 3+ fully responsive template. Built with LESS CSS compilation and CSS3 based on gantry framework 4+. It has a limitless color variations, k2 styling, bootstrap integration and much more.Ankit ParmarPosted in Web Design → Corporate
New launched portfolio website that showcases the latest work with detailed case studies for each project. A clean, simple and fresh new look.Daru SimPosted in Web Design → Portfolio


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Since the late sixties, when a Greek-American messenger named Demetrius began writing the tag TAKI 183 around New York, renegade painting has evolved from a form of aesthetic confrontation to an international marketing strategy. Now it's getting the full-on white-box treatment: Jeffrey Deitch, the newly minted director of L.A.'s Museum of Contemporary Art, looks to make his mark with "Art in the Streets," a definitive survey of the genre. The show contains archival photos documenting the work of legends like Quiñones and Chaz, and 36 installations by today's best-known graffiteurs. Parisian photo bomber JR, known for his colossal portraits of the downtrodden in places like Brazil and the West Bank, will transform an exterior wall; inside, look for work from Brazilian twins Os Gêmeos, famed for multistory paintings of sallow giants that suggest the unlikely spawn of Picasso and Shrek. Reports have it that the reclusive yet ubiquitous British artist Banksy, fresh off a pre-Oscars street-art blitzkrieg, will also be participating—although, naturally, the museum refused to confirm this.
Opens April 17 at the Geffen Contemporary at MOCA,
152 N. Central Ave.; moca.org


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It's late in the third quarter, the Bucs have the ball, and the scoreboard reads 34-9. For long-sufferring Tampa Bay football fans, the breathing is becoming easier, and the rejoicing is ready to begin! After an incredible season and a huge upset victory over the Philadelphia Eagles in the freezing cold NFC Championship game, Jon Gruden's boys kept the momentum flowing right into the Super Bowl, and after dominating early-game performance, were poised to become World Champions. With Brad Johnson ready to snap the ball on first down...SNAP! The moment is preserved for all-time, and is now available for your wall!
With this poster, you are transported back to that stunning Sunday evening in Southern Californa, when a wonderful season turned ugly for the Silver & Black, and a dream season was capped for the Tampa Bay Buccaneers. San Diego's Qualcomm Stadium has never looked better, resplendent in bright blue-and-yellow accents, with huge flags of each NFL franchise stretched across the light standards. Like all prints in photographer Rob Arra's Everlasting Images series, every detail of this beautiful moment is clearly in focus - the action on the field, the spectators, the scoreboards, the sideline entourages, and all the Super Bowl hoopla surrounding the field of play. It is a beautiful piece that deserves a nice frame and a prominent place on the wall of any Bucs fan, Raiders fan or Super Bowl collector, and is a great reminder of another magical night in NFL history!
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2013 ADAP Data Report (ADR) Workshops
2013 ADAP Data Report (ADR) Workshops
September 9, 2013
HRSA HIV/AIDS Bureau
Sessions from HRSA's HIV/AIDS Bureau (HAB) Annual Ryan White HIV/AIDS Program Data Training.
- Review the common challenges grantees faced in completing the first ADR.
- Learn how to improve data quality.
- Get a first look at the tools and reports that will be available for future submissions.
- Work with HAB's TA providers to develop a customized TA plan that meets individual training and reporting need.


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This panorama of Kyle Field at Texas A&M University, taken by James Blakeway, shows the Aggie football team playing in a sold-out stadium. Kyle Field dates back to 1904 when Edwin Jackson Kyle personally underwrote the initial construction costs. The facility was subsequently named in his honor. After several renovations and additions, it now seats 82,600 fans. Known as "Home of the 12th Man," Kyle Field is widely considered one of the most daunting college football venues in the nation. Texas A&M has earned one national title and nineteen conference titles in football. The institution opened in 1876 as the Agricultural and Mechanical College of Texas. Enrollment now exceeds 48,000, making Texas A&M one of the six largest universities in the nation.
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Hang tight!
Recipe by Brenda Laughlin Sumner
"This recipe starts out on the stove, and ends up in the slow cooker! Add your favorite BBQ sauce and eat plain or on a bun! Great for parties."
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1 tablespoon
2 pounds
boneless pork roast
1 tablespoon
Cajun seasoning
1 medium
onion, chopped
4 cloves
garlic, crushed
4 cups
1 tablespoon
liquid smoke flavoring
As a Texas girl living in Montana, I think many reviewers missed the point of what pulled pork is supposed to be. The meat is intended to have sauce added when placed on the bun. You want the smokey flavor of the pork (not all the spices). When you smoke a pork butt (or in this case, cooking it in the crock pot)the purpose is to get the pork very tender. You dress the pulled pork after its done with sauce, Jalapeños, onions, swiss cheese, etc. This recipe is perfect for what it is intended to do--make the pork tender!
I was really excited about making this given the reviews. However, I was so disappointed. I followed the recipe exactly. I put plenty of seasoning on the meat before browning, but the end result was bland shredded pork swimming in a pool of liquid. The directions said nothing about draining the liquid before returning the meat back to the crockpot after shredding it. Am I missing something?
498 Ratings
This recipe was an unbelievable hit at my daughter's graduation party. I did a trial batch with Sweet Babys Rays, and my hubby and I were not impressed. They were sampling "Cattlemen's" BBQ sauce at Sam's and we instantly knew that it was the sauce that would make my main course a huge hit. By the third batch I didn't bother browning the pork, onions, or garlic. Just throw it all in the crockpot and cook on high for 6 hours. The meat was so tender all I had to do was press it with a fork and it fell apart. I did not use the juices in the crockpot after the meat was cooked - it sounds like some did. I stirred the pork in Cattleman's and bagged it in ziploc freezer bags and froze for the big day. I let them set out overnight to defrost. I saved a quart of the juices in the fridge just in case I needed them to revive the pork, but it was not necessary at all so I discarded it. ABSOULTELY WONDERFUL!
Overall, very good if you like pulled pork. I didn't bother browning the pork first though. I seasoned it with "Cajun Seasoning Mix" from this site and added it to the slow cooker along with a bit of minced garlic. I left out the onion (personal perference when it comes to pulled pork). I've done a few "southern" pulled pork recipes and most call for cider vinegar vs. just water so I used 2 cups of apple cider vinegar and 2 cups of water. I let that go for 5 hours on low. I removed the meat and shredded it with two forks. I drained the liquid reserving 2 cups and put that back into the crock pot along with the shredded pork and then added 2 Tbsp. of liquid smoke. I also added a little brown sugar and cayenne pepper. I let that go for another hour on low. This is great topped with your favorite bbq sauce or try "White BBQ Sauce" from this site along with a side of coleslaw and cornbread!
This was really good (granted I adjusted it to suit my own preferences)- the meat came out very tender. The meat probably isn't flavorful enough to stand on its own and so should be made into sandwiches or add barbeque sauce (eta - smokey mesquite bbq sauce will probably be your best bet with this recipe). I made a couple adjustments for this - I used olive oil instead of butter for browning the meat and cooking the vegetables - a little healthier. I used less liquid smoke and added about 2 tablespoons of worcestershire sauce to the slow cooker. I also added a couple sprigs of fresh thyme and one sprig rosemary to the slow cooker and removed it after cooking. I also used 1 can chicken broth and 2 cups water for the liquid in the slow cooker to give it a little more flavor. For cooking time, I kept this in the slow cooker on high for about 2 hours and then lowered the heat for the remaining time and everything turned out really well. I used this for pulled pork sandwiches (on a kaiser roll, with a little apple cider vinegar, some texas pete hot sauce, and topped with restaurant-style cole slaw made from the recipe on this site). The sandwiches turned out really well!! As good as any I've had in the restaurants in the south. I'm not sure that I'd make this to eat without the coleslaw and hot sauce to add flavor or some sort of BBQ sauce, but it was the perfect recipe for the sandwiches.
I really think this is a 5 star recipe. I had to change it a little bit, but only because I could not find a boneless pork roast at my grocer. So I followed the recipe except that my meat was not cut up, I cooked it all on the bone. I used quite a bit more liquid smoke, also. My meat was so tender that it literally fell off of the bone and shredded by itself. lol It was pretty flavorful, but I added additional cajun seasoning and garlic to the meat after I shredded it. I served Jack Daniels BBQ sauce on the side. Great comfort food! Thanks for this recipe!!!
I wouldn't dare ruin this with barbeque sauce, but I did feel the liquid needed more flavoring. Instead of the water, I used beer and chicken broth. I also threw in some pepperoncini peppers with it's juice. My guests couldn't get enough at our dance recital party. Thanks!
Delicous! Cooked 8 hours on low, then added 1 bottle of gourmet BBQ sauce to cook another 2 hours. Everyone agreed as good as any BBQ restaurant! Served with Waldorf salad- perfect side with sweet, creamy, and crisp taste.
* Percent Daily Values are based on a 2,000 calorie diet.
Southern Pulled Pork
Serving Size: 1/6 of a recipe
Servings Per Recipe: 6
Amount Per Serving
** Calories: 178
** Calories from Fat: 91
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Mangos star in this spicy, smoky, slightly sweet slow-cooker pulled pork.
Make this succulent barbequed pork dish in your oven.
Turn pork shoulder into delicious shredded BBQ pork for sandwiches.


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Behind Orlando, Atlanta, Miami, and Washington, D.C., Tampa is the fifth-largest metropolitan area in the Southeast. But unlike these larger destinations, Tampa has lagged in name recognition until recently, when the destination scored a huge win: the 2012 Republican National Convention. It was Tampa's shining moment, and a chance for the city to show off its new wares — as I experienced during a recent two-and-a-half-day visit hosted by Visit Tampa Bay.
Since 2010, $177 million has been poured into revamping the city's downtown and numerous waterfront neighborhoods. The result is four new museums, several new mixed-use developments, new hotels, a massive renovation of the 20,500-seat Tampa Bay Times Forum, and the near completion of the 2.4-mile-long Tampa Riverwalk.
On arrival at Tampa International Airport, I immediately knew where I was. The sunny, airy terminal recently added pared-down versions of the city's most popular local restaurants, including Cigar City Brewing, the Columbia Restaurant Café, and First Flight Wine Bar, a spin-off of the decadent downtown staple Mise en Place. It's a small example of how the city stays loyal to its locals and pays homage to its diverse and rich heritage.
After grabbing my luggage at the airport, I met up with my hosts from Visit Tampa Bay, who took me to lunch at Boca Kitchen in Hyde Park, a cozy neighborhood joint that in the 1920s was a gas station and garage. Boca serves an upscale, comfort-food-inspired menu of mostly local fare, and its Hyde Park neighborhood is filled with turn-of-the-century bungalows and gleaming new mixed-use developments.
While we ate, I learned more about Visit Tampa Bay, which has undergone some big changes recently. Apart from debuting a new logo, name, and brand identity earlier this year, the bureau named a new president and CEO, Santiago Corrada, a Tampa resident who formerly served as chief of staff for the City of Tampa. The brand's sleek, new, pirate-inspired logo and tagline, "Unlock Tampa Bay," aim to set the West Florida destination apart from its neighbors and play up its offbeat, adventurous side.
Back downtown, we made our first stop, at the Tampa Convention Center. The 600,000-square-foot facility is remarkable in that it sits directly on the Tampa Bay waterfront, making it ideal for everything from VIP galas for the Republican National Convention (RNC) to spectator-heavy events like wakeboarding's Red Bull Wake Open. Stacy McGlinnen, national sales manager for the center, gave us the grand tour, pointing out that meeting planners love the venue most for its generous amount of natural light and accessibility. It's so easy to get around, in fact, that the National Veterans Wheelchair Games chose the center for its 2013 event. Spanning four floors, the center has 95 percent of its meeting space on the first level and its 200,000-square-foot exhibit hall on the third.
Beyond the terraces, glassed-walled meeting spaces, and outdoor patios that let guests soak in every inch of the bay, the center is unique in that its waterfront can accommodate everything from firework shows to water taxis and yacht charters, both popular activity options with groups. The Tampa Riverwalk — a pedestrian walk connecting many of downtown's biggest attractions that will be completed in 2014 — passes by the center's front door. And so does the city's TECO Line Streetcar System, whose historic streetcars make 11 stops within downtown Tampa's most popular neighborhoods, including the Channel District, home to the Port of Tampa and the eighth-largest cruise port in the United States, and historic Ybor City, famous for its nightlife and cigar manufacturers. Nearby historic Hyde Park and Soho (South Howard) are home to Tampa's restaurant row.
To top it off, a skywalk connects the center to the 360-room Embassy Suites Tampa — Downtown Convention Center. And within walking distance are four more hotels, including the Tampa Marriott Waterside Hotel & Marina, where I was staying.
From a stop just outside the Tampa Marriott Waterside, we hopped aboard the TECO Line Streetcar (an unlimited day pass costs $5) and took a 10-minute ride to Ybor City for dinner at the Columbia Restaurant. The fifth-generation-owned Spanish restaurant is a staple of the Tampa dining scene, renowned for its live flamenco dancing, encyclopedia-sized menu of Spanish dishes, and, at the historic Ybor City location where we ate, stunning Moorish architecture. Columbia's 15 dining rooms are speckled with indoor fountains, keyhole-shaped doorways, skylights, and colorful tile flooring, making the restaurant one of the most unique and popular event venues in the city.
We kicked off the next morning with breakfast at Armani's restaurant, the 14th-floor Italian jewel of the Grand Hyatt Tampa Bay. The clean and modern space features floor-to-ceiling views of the bay as well as a patio where a retractable roof will be added later this year.
Next, we headed back downtown to see the city's innovative side. CAMLS — Center for Advanced Media Learning and Simulation (affiliated with the University of South Florida) opened in a 90,000-square-foot building in 2012, and offers cutting-edge health-care simulation training and educational facilities. The first facility of its kind in the world, the $38-million CAMLS caters to groups of all kinds — from dental students to medical device companies — that need state-of-the-art spaces and equipment for training, education, and demonstrations.
In an effort to stimulate the other side of the brain, we hit the Tampa Museum of Art, one of four museums that dot the downtown waterfront. In 2010, the museum moved into its current location adjacent to Curtis Hixon Waterfront Park, which was also recently revitalized. The building's lobby atrium and covered terrace overlook the park and serve as a sort of front yard for the museum, and are ideal for receptions and launch parties. As we lunched at the museum's Sono Cafe, I chatted with Jane Han Godfrey, Visit Tampa Bay's senior services manager, who told me about how the waterfront and green spaces like Curtis Hixon are playing a major role in attracting both locals and visitors to downtown. Segway tours, paddleboarding excursions, yoga in the park, and water taxis are a regular sight now, and the accessibility of the Tampa Riverwalk makes jumping from the convention center to an attraction or hotel simple and safe for everyone.
Our last stop of the day was the 6,000-square-foot Vault, a recently restored, blank canvas of a special-event space in the Downtown Arts District. With floor-to-ceiling glass windows looking out on downtown, The Vault features an actual vault — from when the space served as a bank, built in 1923.
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I've just discovered Donata Wenders' web page.
I've been enjoying her photography exhibits there.
And then I found this: Her personal testimony about her faith in Christ.
Read it.
Donata Wenders - wife of Wim Wenders - on her faith
Started by Overstreet , Jul 03 2007 04:06 PM
5 replies to this topic
Posted 03 July 2007 - 04:06 PM
Posted 06 July 2007 - 12:03 PM
I didn't know where she was going at first, but her testimony is a powerful portrayal of God's love as evidenced in our lives. She really captures that concept in her writing.
Thanks for posting that.
Thanks for posting that.
Posted 06 July 2007 - 01:10 PM
I think it's, oh, just really really cool that a woman like that is married to Wim Wenders.
Posted 06 July 2007 - 02:32 PM
QUOTE(Jeffrey Overstreet @ Jul 6 2007, 01:10 PM) <{POST_SNAPBACK}>
I think it's, oh, just really really cool that a woman like that is married to Wim Wenders.
I think it is really cool that Wim Wenders is married to a woman like that.
Posted 25 May 2008 - 04:15 AM
Her photos of Sam Phillips for her Fan Dance album are superb.
Posted 13 January 2012 - 04:45 PM
It's one of the most spiritually uplifting, inspiring programs of this, or any other, year.


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Cytheran wrote:What am I drunk bro?
No. Reality is based on individual perception. So in my reality this forum was not assumed to be WIN. ?
It was assumed to be suck based on prior experiences with gaming forums.
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JEGS Performance Products 50996 - JEGS Radiator Hose Adapters for CSR Electric Water Pumps
JEGS Billet Aluminum Radiator Hose Adapters are designed to connect your electric water pump to a hose or AN fitting. Fits CSR Electric pumps or any other pump with a 3/4" NPT outlet. Features clear anodize finish for protection. Made in the USA.


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Gallery: Richard Meier & Partners Unveil New Aztec-Inspired Mitikah Tow...
The slender and elegant 34-story tower rises above a transparent and translucent building base, and is part of a mixed-use master plan designed by Pelli Clarke Pelli Architects and developed by IDEURBAN/IDCity from Mexico. The project consists of commercial space, low-rise residential buildings, and a hotel and residential tower.
Speaking of the design, Design Partner-in-charge Bernhard Karpf commented: "Mexico City has always been among the most important cultural and commercial centers in Latin America. The new tower will undoubtly contribute visual significance to the skyline of the city and to the neighborhood. The design is inspired by a modern interpretation of Aztec forms."
The building's orientation and facade are a reflection of the site as well as issues of sustainability, maximum efficiency and flexibility. The south and east facades are composed of a continuous high-performance curtain wall modulated by subtle and sculptural folds, while the north and west elevations are composed of a curtain wall system with modular and orthogonal expressions.
Views and daylight are provided via floor to ceiling glass windows, but solar heat gain is tempered with low-E coatings and fritted glass. The efficient curtain wall system is the first line of defense against energy use, and is just one part of the strategy to achieve LEED certification.
The eco tower is expected to be completed in 2014.
Images ©Richard Meier & Partners


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PopDger wrote:Is there a way post a flier on this discussion board? If so would someone please advise. Mini thanx.
PopDger wrote:I have asked for it to be done, but I have not seen the flier online. This is the reason I was asking if there was another way to get a flier posted. Invisible tree, thanks for the offer...PK should have a flier up already.
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