text:
- Nicholas Lukowiak
- Belleville, NJ
- United States
This conversation is closed.
New Age Atheism: The New Frontier of Scientific Ideology
There is criteria which one should follow in order to be a neoatheist:
*Understanding science, religion, supernatural and atheism
~Science is trying to figure out what is true through methods of logic and rationality, while religion does the same thing but through dogmas and old scriptures.
~Supernatural is the silly notion things cannot be explained by science but religion, and sometimes pseudoscience (which is fake science).
~Atheism is the lack of belief in deities
~Religions are the enemy. Buddhism gets a pass because they are hardly a religion - more of a philosophy.
*Make sure to know proper arguments to distinguish atheism from religion:
~"So by the lack of belief in God, I have a belief? So my lack of belief in Santa Claus is "Aclausian?"
~"Is being bold, a hairstyle?"
~"The television being off, a channel?"
*Check out Dawkins, Rosenberg, Dennet and Harris:
~These guys pave the way for what it is be a rational, logical and non-dogmatic person.
~They demonstrate how belief in a God is just nonsensical through science!
~They prove logic is EVERYTHING to how to think properly.
*Being militant does not mean physical actions
~Only extremist harm others for their beliefs, and since we have none there is no need for violence.
~Never allow 'faith' to be an acceptable reason for the other person to avoid an argument.
~Don't be afraid to debate, you are right! Religion is a destructive practice!
~The burden of proof is on those who claim truth!
Always keep in mind something a leader of our movement had to say, which proves powerful:
"That which can be asserted without evidence, can be dismissed without evidence."
-Christopher Hitchens
Let's how a strong discussion here on what it REALLY means to be the neoatheist everyone should be!
As an active blogger and forum user to discuss new age atheism, there are a couple of websites I can share. Once a week we have a podcast for lectures with live commenting! Join in the movement!
Fritzie -
Feb 2 2013: I, like some others below, am confused from your explanation as to what New Age Atheism is. Do I understand that it is a sort of evangelical effort or campaign to use science to disprove the existence of any diety rather than assuming, as most trained scientists do, that science cannot prove or disprove beliefs in that area? And that there is a set of particular arguments you are coached to use with people?
- +3
As you mention pseudoscience, it sounds like the movement also doesn't go for for invalid extrapolations of real science to justify all sorts of stuff? (But then, followers never think their extrapolations are not scientifically valid, so I guess that's a tough one to pin down).
Feb 7 2013: Just trying to get people to think Fritz,
I am obviously no neoatheist lol - basically just claiming the movement to be a disorganized religion. Which is going to get a lot of people either angry or thinking or both. :-D
Dan F
Feb 10 2013: Describing Atheism or your term "Neoatheism" as religion is silly. Religion is the belief in and worship of a superhuman controlling power, esp. a personal God or gods.
- 0
Are you not editing your own personal dictionary to serve your own special needs?
Feb 10 2013: Disorganized religion differs from a full blown tax exemption religion.
Mormons were disorganized for the longest time, a cult, yet through massive numbers of members became a recognized religious practice. Scientology, no different.
By your definition of religion, indeed the neoatheist movement is not a religious movement.
But your definition of religion cuts out a lot of organized religions that exist today. Since there are atheist (or secular) Jews, Christians, Muslims. Buddhism, Hinduism sects, and the subreligious groups which are inspired by the two religions, exist. No superhuman beliefs, but, in fact very organized.
If anything, part of the neoatheist movement (the one you seem to have been submitted to) has gone about changing the definitions and ideas of religion to satisfy argument.
While I say religion involves: dogmas, community, consensus, charity, doctrine, beliefs, faiths, etc, etc.
You're saying religion is all about a higher power - which it's not. Your impressions of religion have became that, no doubt due to the strong Christian image developed in the media today.
Today, when I think 'atheist' I don't actually think of anything universal or global in terms of what that group of people are rejecting, I think they are just rejecting the Judea-God and have labeled anything relative, religious.
In short, no. In fact I am trying to keep my definition as open as possible, and by doing so - recognize how neoatheist are no doubt, moving towards a unified, organized culture and community - which already exist, but not very 'organized'.
I assume by your response, you are a new age atheist? Maybe even on to label themselves 'agnostic-atheist' in order to accommodate the .01 percent chance the Judea-God exist? Fine.
Yet, there is this itching feeling that comes to me, when people place themselves into a debate about a creator God; discussing metaphysical ideologies. Strikingly similar to a religious debate. Not a religion? Yet have a say?
Don Anderson
Feb 1 2013: Wrong Wrong Wrong
- +3
Religion is NOT a belief in deities .
Religion is an organized collection of belief systems, cultural systems, and world views that relate humanity to spirituality and, sometimes, to moral values
How could something that leads people to be civil and good be an enemy?
Are you saying that you are an enemy of good?
Atheism is an organized collection of belief systems, cultural systems, and world views that relate humanity to spirituality and, sometimes, to moral values. And thus atheism is a religion!
You likely hate how people of a religion try to convert people to their belief, and yet that is exactly what you are doing right now!
I have to ask; What makes atheist so fanatical about their religion?
Feb 7 2013: Kierkegaard had it right in my opinion, he said religion was a personal thing. And, that idea holds true or else the [cognitive] psychology of religion would not have much to study at all.
The word 'atheism' itself is not a religion, but the movement definitely takes on the form of a disorganized religious practice, most definitely. The culture just naively labels themselves atheist. Rather they should label themselves - secular humanist or religious naturalist.
What makes neoatheist so rejecting of the phrase 'religion' is because that is what they believe is be the enemy... Which is obviously ignorant once we start traveling East. The Middle East is painted to be this place of dark and evilness due to the non-separation of state and religion. At times (like women rights) that may seem very true, but, women rights is also one of the biggest types of protest in those countries... In time, things correct themselves, with understanding. Any type of forceful thinking is a negative. Which is why atheist feel so correct, because they are being forceful on the opposite side of the spectrum from theist (mainly fundamental Christians).
In totality, atheist, today, are actually gnostic-atheist. As they reject the Judea-God. Had they done real research involving religion, God takes the form in ideas which are various - and with this argument I get the usual "Then why call it God?" Well because that idea was called God way before you were born or any of the people you know or read... So, dismissing the philosophy of God is as barbaric as saying you believe in God and not contemplating what exactly that belief is supposed to mean.
Thank you Don
Dan F
Feb 4 2013: I consider myself an atheist by consequence. I don't get the "new age" idea as if the original definition of atheism is altering.
- +2
I am an atheist as a consequence of being a naturalist. A naturalist sees natural history as a dynamic evolving physical process. That means if a camera was continuously filming from some bluff overlooking some land expanse over geologic time and in turn the film could somehow be rewound and sped up for review, then we would witness the origin of species before our eyes. This concept of natural history best satisfies my sense of curiosity over more artificial man made explanations involving creationism.
Biology and related sciences provided impressive fields of interlocking evidence supporting this world view for the student of such disciplines of knowledge. Not to mention all the other logical reasoning conflicts with the elaborate artificial explanations of how things came to be via some supernatural being.
A movement of younger rebels from religious traditions to adopt a more naturalistic approach in how they view the world is possible. The computer could enable it to happen. Youtube and other features of the computer has made this information easier to understand and more interesting than the typical authoritative classroom learning environment that empathizes the memorizing of elaborate DESCRIPTION at the expense of understanding and discussing the HOWS and WHYS that make the study of the topic a science. Until this practice changes the sciences will continue to lag in US public education because learning only accelerates with an open mind.
Although I don't subscribe to treating atheism as a belief system in itself, much of what you advocate I concur with.
Feb 7 2013: Dan,
This entire post is satire, never or will I ever believe atheism is the future of belief (but the naturalism conditional indeed is the future)... lol read what I said to others and respond further!
I extended this conversation for another week!
Dan F
Feb 7 2013: Yes Nicholas you got me so...
- 0
You made me smile at myself for taking the bait.
Perhaps you have discovered a more effective methodology for bringing more people back to spaceship earth by using wit. No one can doubt the past masterful human creative instincts to develop numerous mystical stories as to how we come to be despite how beautifully we fit into the evolution of the natural world.
Carry on. You may be onto something and I will take a closer look.
So you are injecting a little humor into a humorless topic, interesting.
Feb 7 2013: That's a very interesting interpretation, not my real intentional goal lol, I am more of an antagonist than anything.
Like I said, as long as 'atheist' either realize their dogmas or realize their mislabeling (as they are secular humanist or religious naturalist), I see no problems with these beliefs! Only when the denial of such thoughts being 'religious' is when there is a disturbing delusion in the mix. That delusion believing we are above being religious, when in fact we tend to be naturally.
Thanks for your response!
daniel hehir
Feb 1 2013: ....bad news for you Nicholas, haven't you heard ..??
- +2
High priest and captain Richard Dawkins has abandoned the atheist ship.
He now prefers not to .. "limit" ... his understanding either towards the one conclusion or the other....
He prefers now to be considered an agnostic ... which means one simply does not know... for sure.
Check out the links below
... I guess a word like humility isn't on the agenda here, ...but a lot of young neo-atheists should go do their homework and read some philosophy before they go out demonstrating with their flags and T-shirts and calling themselves "brights" ... as though they know better than all the rest of us. Gods existence has been debated for a few thousand years, and so finally comes the neo-atheists with the right answer.... Smells of arrogance to me.
It's perfectly OK to admit that you don't know ... It might be the first step towards self-knowledge.
Richard Dawkins finally did it. ... I think his self-doubt began to arise in him around the time of Christopher Hitchen's death in Dec. 2011. Death seems to be a rude awakening for human logic.
Self-doubt can also be a virtue.
Logic tells me that...
Feb 7 2013: Lol, high priest Dawkins...
I am sure by now Dawkins had his ear chewed off with philosophers and theologians alike about being so extreme with his ideologies... Surely by now with all the new age movements of religious thinking he would of changed his perspectives. Just like Harris did!
"... I guess a word like humility isn't on the agenda here, ...but a lot of young neo-atheists should go do their homework and read some philosophy before they go out demonstrating with their flags and T-shirts and calling themselves "brights" ... as though they know better than all the rest of us. Gods existence has been debated for a few thousand years, and so finally comes the neo-atheists with the right answer.... Smells of arrogance to me.'
Exactly - and precisely where this conversation's satire exist. With their irreligious attitudes, they are proving more religious than not...
Thanks for your comment!
Mind S
Feb 8 2013: Daniel Hehir,
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I don't see a change in Dawkins stand,
Dawkins wrote in « The God Delusion » that « There is almost certainly no God ». In the newspaper article you mentioned he stated "On a scale of seven, where one means I know he exists, and seven I know he doesn't, I call myself a six, a '6.9' . This means his stand is the same.
"6.9" on seven points scale is the position that would be taken by a scientist towards any imaginary notion that can't be proved or disproved.
Feb 8 2013: Way to maintain that neoatheist status!Feb 8 2013: I guess Dawkins should have called himself an agnostic from the very beginning then... rather than an atheist, as his well established reputation would have it. hmmm .... 6.9 ... sounds like a pretty specific relation to his disbelief. But he does have a shadow of a doubt. .... As most agnostics do in fact admit a small degree of uncertainty, Dawkins too, is then saying, with a liiiiiiiiitle reservation, .... that even though I have aways showed myself in public as THE most self certain, self confident, scientific based, clearest thinking, etc. etc. ..but, I am still not sure... I too must admit that even "I" THE Richard Dawkins cannot say with 100% certainty that God does not exist .... Perhaps Dawkins sees that he too ... just may be a liiiiiittle bit delusional ... or what ? Why suddenly now ( in Feb. 2012) .... Maybe the death of his friend Christopher Hitchens (Desember 2011) has something to do with it. I don't know.
Hitch claimed that he would never turn away from his atheism, not even on his death bed. .. That's a pretty strong statement to make. Was Hitch also a ... 6.9 er .?
I work with dying people. I might know as many as 200 people who have died over the past 9 years... and I'll tell you something... death is something that shakes up your logical thought process. It takes it up by the roots and shakes it around like a rag in the mouth of a dog. Your logical mind tries to fathom the infinite dimension of either being "outside" this physical dimension in another form of existence ... or being extinguished to absolute nothingness. Logic reaches its limits ...
I've got nothing at all against atheists, don't get me wrong. I was also one at a certain point in my life. But "vocalizing it" at every chance, in the media, seems to me to take on a character of "The know it all" as Nicholas satirically presented as his discussion topic on "neo-atheism"
It gives me the exact same feeling as hearing the "christian extremists"
Because it is extremism.
Mind S
Feb 9 2013: I appreciate your work with dying people. I also understand now why you stress "death" in your comments even when there is no direct reference to it in the discussion. This affords me the opportunity to reflect further and forward my thesis.
- 0
What you mention about how death shakes logic is true and it is medically/clinically well known dying syndrome. Often it is described as the delirium of a dying brain, impaired mentality and the mental confusion of a dying person.
This deterioration of brain functions during the dying process, which sometimes creates delusions and hallucinations, shouldn't leave drastic psychological impact that affects views of healthy people towards basic existential issues. We build our knowledge on the robust activity of healthy brain and not on images from decaying, dying brain.
Further, if a person is not prepared, cognitively, to view this mental decline as quite natural process of dying brain cells, then he would find himself negatively obsessed with death, that could lead to submission to existential angst or more commonly being trapped in thanatophobia and the primordial, rudimentary fear from death, which in turn interferes as a catalyst for enhancing supernatural fantasies.
Modern scientific knowledge and naturalistic worldview are apt to provide us with the means to liberate ourselves from superstition-based fears that plagued (and plagues) human societies.
Also, it is unwarranted to exploit our incapacity to know many things to adopt metaphysical notions. One needs to comprehend that the mysteries and wonders of this wonderful and complex existence wouldn't be deciphered even in the lifetime of thousand generations. We face an open and unbounded space of enquiry, and we need to accept this as a reality whether we like it or not; it is something beyond our feelings and preferences.Feb 5 2013: I do not particularly fancy this "Neo-agnosticism" movement; scientific proof and open, logical reason have had the same end-goal for years then and now. Atheism is Atheism and ought to remain so, at least so far as I can see things. It could be very likely that I am misinterpreting your point though?
Feb 7 2013: My point is to paint the picture of this movement as being a religious one. Which is not bad, as long as it is recognized as one. This way, organization can allow members to be more accepting of the diverse approaches there are in this world. There are a lot of already existing atheist religious groups (like Buddhism, shocker!). lol.
... lol, I have this joking idea that Scientology gets a good number of members because of the word 'science' in the name... With this thought, people enjoy attaching to ideas which are both self reflecting and communally enhanced.. Embracing who we are and our natures are great! As long we are conscious of the reasons and conditions.
Read what I said to others, and respond further, if you wish!
Feb 7 2013: I don't think your idea about Scientology is unreasonable, though I have not studied the question. There are other popular belief communities that have found that selling their belief package as science is a very effective vehicle for getting supporters. Their outreach combines real scientific results with pseudoscientific additions that serve the purpose of the organization.
I now understand that your thread opening was satire. What makes me uncomfortable about that approach, to represent a belief system AS IF you are a member and perhaps incorrectly, is that it potentially stirs up antagonism from those who believe you have correctly described the movement.
It's a bit like spreading a rumor about someone- an exaggeration- and then afterwards saying "Only kidding!"
I am not a neoatheist and had not heard of it until you raised this. I would have this concern regardless of the belief system you described.
Feb 7 2013: Well the satiric demonstration comes in the notion that atheist would not recognize their organization because if they did, they would be more like what they oppose.
In fact a TED admin suggested the conversation would not be good as provoking others is a path for negative discussion. But, I enjoy taboo thinking. And I believe the new age atheist are in the first step to making a new religion, one that may be beneficial to the world. But, only if they realize their efforts are driving towards unity of thoughts - which is religion.
If, at the point, I have described their beliefs accurately, that should be more evidence to them 1. they are indeed dogmatic and 2. they should organize into larger groups.
Such as Atheist PlusFeb 2 2013: What happens here on earth is reflected and understood by what happens in the human mind.
Therefore interpreting the world exclusively through science is just as wrong-minded as interpreting it exclusively through religion.
Accepting the world through both interpretations however, is right.
Feb 7 2013: Non-extremism is always good Allan
Ken brown
Feb 1 2013: Neo-Atheism? Is that organized blind crusading Nik? similar to modern American politicians during electioneering? Emotionally driven while maintaining a facade of indifference and if backed into a corner has 25 well rehearsed rejoinders.
- +1
There is an emotional element with some Atheists i know, too close to the blind acolyte and when i've tried to point this out that they are starting to mimic crazy evangelists they don't see where i'm coming from and as usual i've completely wrecked any further communication with them.One of my countrymen who i respect and have had great conversations with and is an avid atheist said once "It's all about position" He's right.
The thing with replacing all faith and the belief that there is always something beyond the horizon is what are you going to fill the void with? Even logic is constrained by itself and can lead to the abandonment of further investigation into phenomena that is perceived to be too circumstantial.
Is the Neo Atheist the spiritual atheist of this centuries early 2000's? or is it a Super Pac in disguise.
Feb 7 2013: Ken,
Read what I said to the others and get back to me!
Feb 7 2013: I was wondering if you were being satirical or there was a new something out there. I can't believe TED suggested this as being tabooish, there are only the usual ghosts here and most of us know the usual response we pass to each other. I tried challenging the latest religion to sweep the world and was moderated and was very surprised by the level of emotional response and indoctrinational propagandist ideology used by these blind knights. You can't call someone bisexual anymore. Quite strange, when the world gets to this level of PC like Britain run for the hills.
I can't say that atheists should adopt the word religion but maybe they should go amongst the FN nations to find that special something without the word religion being involved, they are just now rousing from a long slumber.
Feb 7 2013: There is a new something out there!
'Atheist' movements are very disorganized but there are many. Atheist Plus is a fine example.
Indeed 'religion' is strong, but, there is a benefit to such organization.
Gail .
Feb 1 2013: I don't know what you mean by "neoatheism".
- +1
I know that there are atheists (those who do not believe in a deity) and anti-theists (those who are against all theists - primarily those of the Abrahamic traditions - whether the anti-theist is atheist or agnostic). But I do not know what a neoatheist is.
An explanation would be helpful. Is neoatheism referring to the spiritual (intuitively accessed) realm/dimension that quantum mechanics is showing exists (another unseen dimension or the possibility of other inferred unseen dimensions) that is part of our being? (Or might be if the many worlds theory is correct.)
Feb 7 2013: Well TED lover,
there are two trains of thought I have when I use the phrase "neoatheism"
1. A new age religious movement (who arrogantly call themselves a category of religion; atheism)
2. A paradigm. As MANY scientist today (in response to creationist) pay careful attention to being militant against gnostic beliefs.
Neo - new
New age atheism is neoatheism. In a sense, it is not very 'new' but the process of calling the culture of thought / new age religion "atheism" is recent in time.
So a neoatheist is one who flaunts his atheism (or 'agnostic-atheism'), overstates metaphysical concepts like 'religion' 'supernatural' 'science' and 'dogma', patterned arguments (see list above), idols, forums, blogs, and more. Basically a religious person, without the organized part of going on Sundays and having picnics. Although recently I became aware of Atheist Plus http://atheismplus.com/ and how they are actually trying organize more.
Lastly to respond more directly:
" Is neoatheism referring to the spiritual (intuitively accessed) realm/dimension that quantum mechanics is showing exists (another unseen dimension or the possibility of other inferred unseen dimensions) that is part of our being?"
Spiritual, yes.
But, what it exactly shows, to me, is religious behavior is natural to human beings. As far as what they want to believe in... is up to the religious organization between the individual and the groups.
And whatever it is westerns decide to dictate in quantum mechanics outside of mathematics, is holistic philosophy... We just took a very long time and tedious method in order to question what Easterners have been questioning thousands of years with their religions and philosophies.
Thanks TED lover for responding.Feb 1 2013: I fail to see how Atheism is any more or less scientific than any other belief system. I became a Christian in middle age by looking at the science; my choice, others chose otherwise. Let's get to brass tacks ..
I live my life in the expectation of eternal life. This motivates me to emulate my God in Jesus Christ. He spent his time on earth loving & caring for people. I do likewise. If I am wrong, & I pass to oblivion, what does it matter ? I am none the wiser; but my life is lived in the expectation.
You believe this life is all there is; an altogether miserable prospect in my eyes. You have to cram everything into this life. Whether this includes helping others is down to the individual & arbitrary. If you are wrong, you are in trouble.
Who would you like to live next door to ?
Feb 2 2013: Yes, it is a miserable prospect, but whether or not a person is afraid to die shouldn't affect their beliefs. Nor should a fear of being damned to eternal hell. In no way do i direct this at you, because I'm sure you have your own very valid reasons for belief, but if somebody consciously decides to become religious for either of those reasons, then they are compromising their principles in a way that i actually find quite cowardly. In fact, I believe that if there was an omniscient god, and he could truly see into the hearts of men, then he would rather accept into heaven those who may not worship him, but regardless, live their lives in a more respectable manner.
Also, if you need help differentiating between theism and atheism:
From what I can tell, it sounds like you see Atheism as a choice - a belief that there is no god. However Atheism is as much a belief as the belief that there is no flying spaghetti monster. it does not make a leap of faith, but rather refuses to make any leap at all, and refutes all statements that require such a leap. In a way, refuting those statements absolutely is a leap in itself, but can you see the subtle difference?
Finally, I rebuke your final question, and although I am not atheist myself, I find it offensive. I'm sure I don't need to tell you that Atheists live by the same moral code as everybody else - a code remarkably similar to that taught by Jesus Christ.
Feb 3 2013: Hi Jonnie,
Last point first. Human beings are all equipped with a conscience by their creator. As that creator IS Jesus Christ, it should come as no surprise that the teachings are similar.
I admit that I see Atheism as a choice to reject the notion of a creator god. Looking around at the high tech nano technology that underpins the whole of nature, it seems obvious that a creative intelligence is a possibility. The rejection of this perfectly valid notion is what I see as Atheism. Even Dawkins admits to the possibility, but admits that the Spaggetti Monster is a figment of his imagination.
He'll has never bothered me as it doesn't apply to me.
Feb 3 2013: You make it sound like we are all equipped with the same conscience, and that our actions for good or evil are merely choices on whether to follow that conscience or not. Do you believe then that the human race has grown less evil over the last 200 years since the abolishment of slavery, then racism and sexism? Because I don't believe that the people that lived back then felt the same pang of guilt as we would do now.
The teleological argument is indeed attractive. I won't debate the existence of God with you, but I will say that for an atheist, especially one who is well versed in the natural sciences, the development of nature through evolution is equally obvious and they see no reason to make a faithful leap when there is a perfectly valid explanation already.Feb 4 2013: Hi Jonnie,
I believe man has always had the same conscience. We can harden parts or all of it by going against it. No doubt the slave traders managed it, the Nazis managed it, the communists managed it, & the suicide bombers manage it. We are not any more or less evil than our forebears, we are just different.
Nero had his choices to make, as did the 911 bombers.
Evolution & ID are two different solutions to the origins problem. To the Christian the ID leap of faith is smaller, to the Atheist the Evolution route requires the smaller leap. However both are faith based, as neither can be empirically tested. It's probably healthy that life has a bit of mystery left.
Feb 10 2013: Peter,
Your beliefs are shockingly Judaic and Buddhistic. Have you ever read or learned anything from these practices?
Do you feel as if it is possible an alien race made us, do you believe an alien race exist which is a thousand years more advanced and able to do such? Would they have created the mechanism in our brains to be aware of God's existence? Or, would they be limited to the knowledge of their own intelligence, and have to duplicate that, which 'that intelligence' having to have the God component?
My guess will be no. The above is not possible to you. That's my assumption.
Yet, through time we have had documentation destroyed and replaced and replaced with replacements. 2000 years is a long time. However, for over 200 years we have had thinkers and scientist alike - understand how microevolution predicts a macroevolution. The evidence of change, theorized with, creates larger theories about already found evidence.
I am not doubting God, in fact I enjoy expanding the idea. However, evolution is a fact. If God, in your image or any other image, exist, that does not defeat evolution, that defeats fundamental biblical readings.
God would then be an Architect. Designing our DNA to adapt and evolve through time and space. Yet, we were evolutionarily lucky enough to get consciousness. Perhaps all animals believe in God, in some primitive fashion. The strive to survive, is something we cannot say no animal has. Maybe God is survival. Or, Xe was super-intelligent enough to design life with the mechanisms necessary to survive.
Perhaps at different levels of consciousness we are doomed to behaving more proper, or divine - in an objective sense. I can see that.
Still, by understanding God, we understand nature, but that is vice versa. Naturalizing thoughts (or scientific lens) craft additional realities (as you noted).
How can you say you understand nature but not a fundamental principle?
"All is change" - Water. Chi (Qi). Evolution is God.Feb 10 2013: Hi Nicholas,
You assume correctly regarding aliens. Their existence would only beg the question of where they came from. I am intrigued that you (& Dawkins) should consider the possibility. On the one hand you state that evolution is a 'fact' & that no god figure is required, but entertain a superior intelligence just so long as it isn't 'God'. If Aliens are a possibility, then why not god?
However if evolution, in the Darwinian sense is a 'fact' of nature then there is no need of god. I do not see evolution as a fact in any but the micro sense; variation within kinds. This can be observed, but there is no reason to believe it can grow to macro proportions.
Neither is there any evidence to encourage the abiogenesis theory; without which, evolution is dead in the water.
Human beings are fairly smart; not as smart as they think they are; but fairly smart. We can get fairly close up & personal with the awesome nano-engineering in nature. We know our limits with regular engineering in the real world, we are light years behind what we observe in nature. Our limits are forgivable, we are not that smart. However we really let ourselves down when we proudly declare that this awesome technology assembled itself over millions of years by blind chance. The fact that our seats of learning & the media have been beating this drum for decades is unfortunate. Many follow the piper, but in reality the emperor has no clothes.
:-)Feb 1 2013: IMO, "Scientific Ideology" is an oxymoron.
Feb 7 2013: IMO, knowing definitions before making wild claims is essential for debate.
Feb 7 2013: I was well aware of the definition, and thus my opinion. If we disagree, perhaps our difference is regarding the term scientific.
I was not engaging in your debate, just expressing my opinion of your phrase.
Have a good day.


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Shipping Weight:?1.3 lbs (0.59 kg)
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- Product Code: REB-02113
- UPC Code: 094922021137
- Package Quantity: 16 oz (454 g)
- Dimensions: 2.4 x 2.4 x 8.1 in, 1.1 lbs (0.5 kg)
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Product Overview
- Expeller-Pressed High-Linoleic Safflower Oil
- Clinically Studied Ingredient
- Patent-Pending SAFActive78 Emulsification Technology
- Dietary Supplement
A clinically researched solution for specifically reducing belly fat!
SafSlim is a revolutionary, scientific breakthrough that specifically reduces belly fat. It's main ingredient—high-linoleic safflower oil—showed in major university studies conducted on post-menopausal women who has high blood sugar and wanted to lose weight, an average reduction of 6.3% belly fat hormone adiponectin by an average of 20.3%.
SafSlim is powered by patent-pending SAFActive78 emulsification technology.
Some study participants lost up to 9.3% belly fat.
Suggested Use
Take 1 tbsp twice daily before meals. Delicious by the spoonful or mixed into cold beverages, shakes or yogurt. For best results, take for a minimum of 16 weeks and use in conjunction with regular exercise and a diet free of high-glycemic refined carbohydrates and trans fats.
Shake well. Refrigerate after opening. Tastes best cold.
Other Ingredients
SAFActive78 high-linoleic safflower oil, water, xylitol, glycerine, natural flavors, gum arabic, citric acid, xanthan gum, guar gum, beta carotene, sorbic acid, vitamin E (as d-alpha tocopherol) and ascorbyl palmitate.
Does not contain: GMO, gluten, dairy, wheat, soy, yeast, lactose or milk.
Please check with your healthcare practitioner if you are pregnant or nursing before taking this product.
Keep this product away from pets.
|Supplement Facts
|Serving Size: 1 tbsp (15 ml)
|Servings Per Container: 30
|Amount Per Serving
|Calories from Fat
|Total Fat
|5 g
|Saturated Fat
|0 g
|Trans Fat
|0 g
|Polyunsaturated Fat
|4 g
|Monounsaturated Fat
|0.5 g
|Total Carbohydrate
|5 g
|0 g
|Vitamin E
|Palmitic Acid
|324 mg
|Stearic Acid
|108 mg
|Oleic Acid
|863 mg
|Linoleic Acid (LA)
|3883 mg
|*Percent Daily Values are based on a 2,000 calorie diet.
†Daily Value not established.
iHerb Customer Reviews
I loved the taste of the tangarine and I have managed to lose some of my belly fat and it has only been 3 weeks. I have not been doing anything different as I am in a wheelchair so exercise is not really an option
It is a lot of money to pay for a creamy drink, and I can't say for sure that it works, to be honest. I think it does have some effect on curbing my appetite through the day, but when I'm hungry, I'm hungry...


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First Impressions of Indonesia
29 November 2012
Categories : Culture and Heritage - Travelings
As traveling two weeks in Indonesia, I got to see the major attractions around the country. While I was visiting nine different islands, these were the first impressions I got. Islands Officially, there are 17,000 islands Indonesia. 8,844 of them have been named by the government of Indonesia, including major islands: Kalimantan (Borneo), Sumatra, Java and so on, and 922 of them are permanently inhabited. It's not hard to guess Indonesia is a big...
Tag : Borobudur, Batik Solo: Keeping The Tradition Alive, Tanjung Puting National Park, Komodo National Park
The Wonders of Borobudur Temple
30 November 2012
Categories : Culture and Heritage
Been there twice in a year! On my recent trip to Central Java, I visited Borobudur Temple in the early hours to catch the sunrise. Without many tourists around in the morning, the whole atmosphere was calm and surreal. I could count with my fingers how many times I really got up very early for sunrise photography. Such trips like this is worth sacrificing some sleep to catch the magical sunrise. Silhouette of the stupas during sunrise. The morning...
Tag : Borobudur, Understanding the Thousands of Relief Panels of Borobudur
Introducing Borobudur Temple
30 November 2012
Categories : Culture and Heritage
Borobudur temple is a Buddhist temple in central Java. It was built around the end of eighth century but it took three generations to finish it. During my two weeks trip in Indonesia, I had a chance to visit Borobudur temple at sunrise. World's Largest Buddhist Temple By Guinness World Records, "The largest Buddhist temple in the world is Borobudur, near Yogyakarta, central Java, Indonesia, built between AD 750 and 842. The 60,000 m ( 2,118...
Tag : Borobudur, Understanding the Thousands of Relief Panels of Borobudur
The magnificent Borobudur Temple
30 November 2012
Categories : Travelings - Culture and Heritage - Sightseeing
High on a mountain in central Java, Borobudur Temple rises up towards the sky. In Buddhist belief, the closer you are to Heaven, the closer you are to the gods. And as you climb the steps of the temple, the jungle landscape of Indonesia revealing itself in every direction, you can understand how the people who built this masterpiece felt more connected to the ethereal than the earthly. Borobudur was built in the eighth and ninth centuries but, at some point in...
Tag : Borobudur
The Beauty of Yogyakarta
5 December 2012
Categories : Travelings - Culture and Heritage - Sightseeing
Yogyakarta is the second most popular destination after Bali in Indonesia. Also known as Jogjakarta, the beautiful city never fails to amaze with its old world charm and natural beauty. Steep in history, Yogya is the centre of Javanese art and culture, the cradle of civilization on Java where a few world heritage sites are located in the city and surroundings. It is the gateway to one of the world wonders – Borobudur Temple, Prambanan Temple and...
Tag : Yogyakarta


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I know what one of them is なくてはいけません and the other one なければなりません, I just don't know which is which, also a few example sentences would help a lot, thank you.
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Japanese Language Stack Exchange is a question and answer site for students, teachers, and linguists wanting to discuss the finer points of the Japanese language. It's 100% free, no registration required.
Obviously ・・・しなくちゃ is a contracted form of ・・・しなくては(なりません)/・・・しなくては(いけません).
・・・しなければ can be contracted into ・・・しなけりゃ but we don't say '・・・しなけりゃ。' to mean 'I gotta do...'
And I think ・・・しなきゃ is a contracted form of ・・・しなけりゃ(いけない)。
You can also say 勉強しないと。/勉強せねば。


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Boston is No. 1 on Parenting magazine's 'Best Cities for Families 2012' list: Share your favorite family-friendly aspect of Boston
David L. Ryan/Globe staff
Parenting Magazine thinks Boston is the best place to raise a family. That's right, Boston ranked No. 1 this year on the magazine's annual "Best Cities for Families 2012" list. Go us!
How was it calculated? The magazine ranked 100 cities based on education, health, community, charm, and culture, using nearly 4,000 pieces of data. The obvious reasons why Boston topped the list, according to Parenting, was our "thrilling hometown baseball team, incredible institutions of higher learning, gorgeous parks, historical neighborhoods and a new highway system."
Other factors the magazine took into account? The White House selecting Orchard Gardens K-8 for a prestigious art program led by famous cellist Yo-Yo Ma, Boston Children's Hospital housing the world's largest research center based in a pediatric hospital, and the Boston Children's Museum's $365,000 grant to ensure programs appeal to all children. Oh, and the magazine was impressed that students at 25 schools across Boston are taking part in a before-school exercise program created by a local mom.
Share with us your favorite family-friendly aspect of Boston.
About Parent Buzz
Browse this blogby category
Kristi Palma, Boston.com Moms producer, is the mom of a first grader and a preschooler. She is a writer who enjoys cooking her grandmother's Italian recipes (when her son isn't launching paper airplanes into them). Follow her on Twitter @kristipalma.
Jennifer Clark Estes is a teacher, writer, blogger, and the mother of four young children. In her free time, she blogs at A Mom's World, plays with the kids (or chauffeurs them around), and is desperately seeking a quiet spot so she can read a book. Follow her on Twitter @JenniferCEstes.
- A Mom's World
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Recent blog posts
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- Baby names banned in Sonora, Mexico: Facebook, Circumcision, and more
- 14th Annual Winterfest, Lowell, Feb. 21 - 22


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The aims of the programme are to:
- Approve quality ACCA learning providers that have demonstrated their success in supporting students through ACCA qualifications.
- Support our learning partners in providing students with the opportunity to succeed.
The levels of approval are:
- Gold
- Platinum
Approval is given to learning providers who demonstrate that they meet the challenging performance targets set by ACCA which are detialed in the Apprvoal Guide document below. Gold and Platinum approvals are granted only to quality learning providers that ACCA is confident in recommending to students.
Gold approval is the first level of the programme and requires learning providers to meet a range of challenging performance targets covering the institution's overall management and, more specifically, its ACCA course management and delivery.
Gold approval can be given to learning providers who are teaching any ACCA qualification – ACCA or Foundation level– through face-to-face tuition, distance learning, E-Learning or blended learning.
Platinum approval is the highest and most prestigious level of the programme and is available for face-to-face, distance learning, E-Learning and blended learning providers.
In working with Platinum approved learning partners, ACCA aims to provide students with access to the tuition and support they need to become ACCA members. For this reason, Platinum approval is given only to those who teach the ACCA Qualification.
To be considered for Platinum approval, learning providers must already be Gold approved and, in addition to the performance targets that have been demonstrated to attain Gold approval, they must also meet ACCA's Platinum performance targets and Platinum pass-rate targets over two consecutive sets of exam results.


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52 Products found in Glamping
With music festivals through the summer and surfing becoming more popular, more young people than ever are buying tents and getting interested in going camping. However, the rugged outdoors aren't too appealing and more people than ever are trying to combine their home creature comforts with the cheap-and-cheerful vibe of sleeping in a tent. Upscale camping, glamourous camping or 'glamping' is very popular and there are sites to accommodate visitors across the UK.
Between Leeds/Reading Festival, Glastonbury and other music festivals glamping in England is more popular than ever. As well as music festivals many camp sites now offer 'pods', or wooden huts, about the size of a large tent. The other advantage of staying in one of these pods is that you don't have to take it down when you leave!
Another great way to glamp is to go down to the south west coast and enjoy the quality beaches in Devon and Newquay. If you want to go glamping in Cornwall take a search through our glamping deals in the south west and find which short break deal is good for you trip away. It might make a nice little summer break away to one of the few places in the UK to get some sun!
If you're less interested in the earth than the sun, peruse our selection of short breaks glamping in Wales. Check our selection of environmentally-friendly glamping holidays in Wales. You can check into a tree house retreat or a tipi in the Welsh Mountains and enjoy a few days on a remote camping location.


text:
For instance, say I had a few sweet background images I wanted to use to identify each one.
Take the 2-minute tour ×
Ask Different is a question and answer site for power users of Apple hardware and software. It's 100% free, no registration required.
There's no built-in feature in OSX for that but there are two applications that can do that for you, Hyperspaces and SpaceSuit.
Mac OS X Lion supports this out of the box now. Simply switch to the Space you want to apply a certain background to, then change it as usual (with System Preferences or the desktop's context menu). Repeat for your other Spaces and background images.
For older versions, you will still need to use a third-party tool as recommended by the other answers.
You have to use a third-party tools, like SpaceSuit.


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Clothing for Girls
Clothing for Boys
Girls T-Shirts
Boys T-Shirts
Shoes for Girls
Shoes for Boys
Baby & Children's Pettiskirts
Hats for Boys
Hats for Girls
Headbands & Hair Clips
Size:Please Choose3-12 months12 months - 2T2-4 years
Raspberry Sun Hat with Peony by Jamie Rae Hats
Shield your little girl from the sun's harmful rays - while keeping her classy - with this fabulous sun hat from Jamie Rae Hats! Made from 100% cotton, this sun hat is an easy fit for your child. The baby size is 46 cm and the toddler size is 49 cm. Jamie Rae was blessed with two lovely children who were not-so-blessed with hair until age two! Luckily, Jamie had always had a love for hats, so she searched high and low for unique hats that actually fit her children. Finally, Jamie decided to turn her passion and search for kids' hats into a business! Since 2005, Jamie Rae has offered little ones with adorable hats and accessories that both child and parent can absolutely love. Find a sweet flower hat, wild tie dye hat or trendy hair clip that will match your boy or girl's personal style perfectly!
Category: Gifts, Hats for Girls
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Jungle Gardenia Eau de Parfum
The Original Scent of Jungle Gardenia from 1932, as Fresh as a Garden in Full Bloom
Jungle Gardenia Eau de Parfum
The Original Scent of Jungle Gardenia from 1932, as Fresh as a Garden in Full Bloom
What Our Customers Are Saying about Our Jungle Gardenia Eau de Parfum …
"There are really no words to describe me elation when I saw Jungle Gardenia in your most recent catalog. My parents were 'courting' during WWII and my dad would frequently buy Jungle Gardenia for my mom. It was her favorite scent, and my dad, not being much of a shopper, felt this was a gift he couldn't go wrong in giving. He was in the Army Air Corp and would therefore fly to many different locations. If there was Jungle Gardenia to be had at any of these places, he would purchase it for my mom. Of course, she thought this was the most romantic gesture in the history of the world. My dad continued to give my mom Jungle Gardenia until it was no longer to be found in stores. Because both my parents always found the glass half full, or even brimming, my mom retained a good outlook on life after my dad passed on several years ago. They'd shared nearly a half century of a happy marriage, and my mom's stories and recollections about her life with my dad are always humorous and joyous. Jungle Gardenia plays a part in many of those recollections so of course I am ordering some. I'm looking forward to giving it to my mom at Christmas. I know this scent will enchance some of my mom's most precious memories of my dad. Thanks again for offering Jungle Gardenia in your catalog." - Cindy Tricoski, Pottstown, PA
"Jungle Gardenia is a long-time fragrance, far beyond my time. I heard about it from Ms. Patti La Belle. The smell of this perfume is so unforgettable and smells so so beautiful. Please keep it on the market. It's one of my favorites." - Deborah, Newburgh, NY
"I first received Jungle Gardenia as a gift from my junior high school sweetheart back in 1969. It was his mother's favorite. I fell in love with the scent and wore it for years until I could no longer find it anywhere. I am delighted that it is making a come back...much like my junior high sweetheart. After getting married right out of high school and divorced a couple of years later, we have reunited and have been married over three years! This fragrance will add to our deep love and affection for each other bringing pleasant memories of not only our early romance, but fond memories of his mother. Thank you!" - Kelly, Chuluota, FL
"Wearing Jungle Gardenia always made me feel so feminine and romantic." - KAY MARTIN, Irondale, AL
"I have not ever met a man yet who did not love this scent. It is romance personified." - Linda Yarbrough, Newnan, GA
"Have worn Jungle Gardenia since High School. This perfume is what attracted my husband and I am now 65yrs old. A few years ago I was buying Jungle Gardenia 6 or 7 bottles at a time from "The Fragrance Depot" and then all of a sudden I couldn't find it. My husband commented several times how much he liked my perfume, Jungle Gardenia, and why didn't I wear anymore, & I explained that I couldn't get it anymore. When I had it and wore it I would have several people comment how nice I smelled and what was the perfume I wore, and amazingly enough most of the people commenting were men! Unfortunately I can only get one, as we are retired and on a fixed income. Thank you for having it so I can wear it one more time. Love you for it!" - Dott Brackin, Glen Rose, TX
"One of the best perfumes ever made. I just love the sweet, sexy smell!" - Rhonda Jonnson, wichita, KS
"I was a very shy and quiet teenager. My family moved a lot and it was common for me to change schools 2 or 3 times a year, so making friends just became too much trouble until my sophomore year in high school and a wonderful teacher by the name of Pamela Willis. She taught Psychology and had a way of drawing you out of yourself and making it easy to become a part of the group. Every day my first class started me off right and I knew the day was going to be good when I smelled her perfume the minute I entered the classroom. She always wore Jungle Gardenia, and that wonderful, sweet smell brings her to mind and reminds me of how she changed my life with her kindness. As soon as I was able, I bought my own until it disappeared. It always made me remember to pass that kindness forward." - Jan Rutledge, Harrah, OK
"I am one of those people who have scents "turn" on them and smell awful. So many don't end up smelling like they are supposed to. I started wearing Jungle Gardenia in 1962, and it is still the only perfume that doesn't turn on my skin. It's getting so hard to find . . . I'm happy that at least for the time being I am able to get it at the Vermont Country Store! Thank you." - Peggy Darling, Wheatland, WY
"My mother wore Jungle Gardenia and Shalimar... that's it. I so fell in love with them both. When I married, I left all the requisite roses behind, and filled our wedding with gardenias. Roses for weddings are pretty, but unscented. But my gardenias made one heck of a hit. They were in my hair, in my bouquet, the ushers wore them, *lol*. And to this day, everyone who attended, when they see me, remark... "Remember those Gardenias? I'll never forget them." And, it seems, they haven't, *lol*. Thanks for bringing back this fragrance... it's just timeless." - Phoenicia, Flagstaff, AZ
"This fragrance reminds me of my early high school years. My stepmother wore it and I would sneak into her bathroom and spray some on as I couldn't afford to buy any myself. Now that I'm 51 years old, I bought a bottle for myself for Mother's Day and have traveled back in time! I am so grateful to your company for returning one of my favorite memories in the shape of a little glass bottle. I will be a forever loyal customer!" - Laura Fopiano-Cox, Hamilton, GA
"Like many, I started wearing Jungle Gardenia in high school and it was my main perfume until I could no longer find it. The new one that came out a few years ago just did not smell right. Guess it was because they were no longer able to use ambergris to make it. Anyway, the frangrance didn't last. My daughter found Jungle Gardenia at your store and bought me some for Christmas a couple of years ago. Her comment to me was, "Now you smell like my mother!" So that scent memory was part of her that she loved. Thank you so much for having this wonderful product available again." - Penny Malburg, Rio Rancho, NM
"I have been looking for Jungle Gardenia for over five years. I continued to surf the web hoping I might find it. As I surfed tonight for the web sales, I decided to see what Vermont Country Stores had for gifts this Christmas when I saw the ad. At first I did a double take and said, "Well, I'll be!" Back in the late '60s, there was a man who followed me two blocks. He startled me, and I thought he was going to attack me. As I got my body ready for a fight, the man said he was sorry for scaring me and he had been following me for more than a block and would I please tell him what perfume I was wearing -- he'd like to purchase it for his wife! I told him the fragrance was called Jungle Gardenia. What a memory! Thanks, Vermont Country Store. Keep it in stock as I call my friends." - Shirley Marrero, Baton Rouge, LA
"Received your catalog today, and when I saw that you were offering Jungle Gardenia, my heart skipped a beat! I have worn it since I was in my 20's and was so disappointed when it was discontinued. All these new celebrity fragrances smell alike and pretty awful, too. I am giving it to myself for Christmas. I can now tell my friends and family to quit looking for it!"-Andrea, Spring Valley, WI
"I have used Jungle Gardenia for over 40 years. I could not find it for many years until a friend told me how to get it on the internet. I am so happy to finally get it. Thank you so much for keeping it so we can get it." - Margaret Woody, Santa Fe, TN


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Hang tight!
Recipe by prissycat
"This is a very light dessert recipe from my friend, Ellen. It is so easy to make and is the perfect ending to a heavy meal."
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1 (5 ounce) package
instant vanilla pudding mix
3 cups
cold milk
1 (9 inch)
angel food cake, cut in cubes
bananas, sliced
1 (16 ounce) package
frozen strawberries, thawed
1 (12 ounce) container
frozen whipped topping, thawed
Excellent! I made a few changes after my husband said it was a "little heavy". I used real whipping cream. After whipping and after preparing the pudding according to the box I gently folded the two together. I also used fresh strawberries. I then placed the cubed angel food caked in the bottom, then whip cream and pudding mixture followed by freshly sliced strawberries and continuing for 2 more layers. I topped the last layer of strawberries with freshly whipped lightly sweetened cream and garnished the top with uncut strawberries. I got rave reviews! It was light, simple and a perfect change from heavy desserts! BRAVO!!!
I love trifle and make it often, but this recipe had way too many bananas for our taste. I made my own whipped cream instead of cool whip. Everyone kept asking me if I had used banana pudding and it wasn't really flavorful other than the banana taste.
*Tip-dip banana slices in orange juice to prevent browning.
485 Ratings
I used cheesecake flavored pudding (SO good!!) and real whipped cream with a touch of vanilla and sugar, insted of Cool Whip. This is a show stopper!
I made this for 4th of July. YUMMY and Beautful in my trifle bowl. I did make a few changes. I used 1 pint of real whipped cream and whipped it fluffy/stiff in my mixer and added about 3 to 4T of sugar to sweeten it and used in place of the frozen whipped topping. I also used lady fingers in place of the angel food cake. And to keep with the 4th theme, I used fresh strawberries and a row of fresh blueberries(instead of bananas) in the middle. I know I changed a lot of the recipe but I thank T's Mom for inspiring me!
Excellent! Light and delicious. Pudding is supposed to be the largest sized box. I now use 2 1/2 cups of milk in the pudding and fresh berries when they are in season.
Delicious and forgiving recipe. I was short on time so I used the strawberries still frozen (cut in half) and slices of whipped topping, then chilled only 2 hours, but it still tasted great! It makes a huge amount and doesn't store well (brown bananas & soupy at the bottom by the next day), so unless you are feeding 10+, you may want to half the recipe.
There are just not enough words to describe how delicious and absolutely FABULOUS this dessert is !! It's so light & creamy and all the flavors just blend together perfectly.
Make sure you don't use skim milk when making the pudding -- it won't be thick enough & watery instead. I used French Vanilla pudding and it was sooooo good ! Also made mine with fresh strawberries & put a few stawberry & banana slices on the very top for garnish.
I served this in a glass trifle bowl and everyone thought it was just beautiful-delicious too! Huge hit with my family-thanks for a great recipe.
* Percent Daily Values are based on a 2,000 calorie diet.
Strawberry Trifle
Serving Size: 1/12 of a recipe
Servings Per Recipe: 12
Amount Per Serving
Calories: 242
Calories from Fat: 58
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Kancamagus Highway
Route 112
Lincoln - Conway, NH
Stretching from the Pemigewasset River at Lincoln 34-1/2 miles to the town of Conway, this scenic byway climbs to nearly 3,000 feet as it crosses the flank of Mount Kancamagus, featuring many scenic vistas and campgrounds.
The original route was started in 1837, but it wasn't until 1959 that is was opened and paving completed in 1964. Since 1968, the road has been opened year round except in the most dangerous winter weather. It was dedicated as a National Scenic Byway in 1989.
There are numerous day hikes accessible from the highway, including a hike to the breathtaking Sabbaday Falls that can be done in less than an hour.
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06 March 2010
Posted in Press and Media
Taste Exotic Foods Dipped in Chocolate During "Double Dare You" at The Festival of Chocolate
Saturday & Sunday, March 6 & 7, 2010
WHO: The Festival of Chocolate "double dares you" to experience the wild side of chocolate with tastings of exotic foods dipped in chocolate. Can you handle it?
WHAT: The "Double Dare You" activity at the Festival of Chocolate will feature colorful creations like chocolate-dipped jalapeno peppers, pork rinds, pop rocks and gator jerky. Combine an old favorite with some distinctive new tastes as delicious chocolate embraces spicy, savory and a few downright odd flavors. Don't miss the chocolate-covered Gummy "zits."
WHEN: Saturday and Sunday, March 6 and 7 - 10:00 a.m. to 5:00 p.m.
WHERE: Orlando Science Center, 777 E. Princeton Street, Orlando 32803
WHY: The Festival of Chocolate is the region's largest chocolate shopping, tasting, educational and interactive experience. With four floors of vendors, displays, competitions, workshops, demonstrations and so much more, it will stimulate the mind as well as the tastebuds. Guests will also explore the history and cultural significance of chocolate with themed museum displays.
COST: Admission to the Festival of Chocolate is included with the general admission to the Orlando Science Center, which is $17 for adults and $12 for kids (ages 3-11). During the Festival of Chocolate, guests are also welcome to experience all the Science Center's exhibits, including Frogs and Science in Toyland and giant screen films like Amazon and Mystic India. Each ticket purchase will be entered into a Chocolate Decadence raffle drawing featuring many gourmet chocolate creations from Central Florida's most acclaimed businesses
During the Festival of Chocolate, guests can purchase delectable delights using "Chocolate Chips" as currency with the vendors. Chocolate Chips have the value of $1 and are the ONLY currency accepted for purchases during the Festival of Chocolate. Chocolate Chips can be purchased at the time of ticket purchase and throughout multiple booth locations with CASH, MASTERCARD OR VISA.
INFO: Visit www.festivalofchocolate.com or call 407-514-2000.


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Kilimanjaro Rongai Route Trek
Tanzania, Trek & Walk, 8 days - from £1,595 (land only) - from €2,235 (land only) - from $2,580 (land only)
Visa Information
The easiest way to get your Tanzania visa is on arrival at the airport. The fee for a single-entry tourist visa is approximately US$50 (please note visa fees are subject to change by the Tanzanian Authorities without notice to KE). The fee can be paid in US dollars or Tanzanian Shillings. Please ensure you have a sufficient amount of cash in US dollars. A passport sized photograph is also required and we recommend you travel with four passport sized photographs for emergencies.
If you prefer to obtain your Tanzania visa in advance this is also possible. Please refer to the website of the Tanzania Embassy or High Commission in your own country for details.
Please note a current Yellow Fever vaccination certificate is required for persons travelling from any country where yellow fever is endemic.
We do keep our information up to date but be advised visa requirements are subject to change. It is recommended that you contact the relevant commission in case of recent alterations.
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Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
Residence "Les Chalets de Barbessines B-C". In the district of Petit Châtel, 1.5 km from the centre of Châtel, in a quiet, sunny position. In the house: lift. Parking. Shop 20 m, grocery 1.7 km, restaurant 100 m, bar 1.5 km. Golf course 3.5 km, chair lift 50 m, gondola lift 1.5 km, ski bus stop 20 m. Please note: ski bus (free of charge). There are more similar properties for rent in this same residence. Access to the residence from 3rd floor. 2-room apartment 32 m2 on 1st floor: living/dining room with 1 double sofabed, TV and DVD. 1 room with 1 double bed. Entrance hall with 1 x 2 bunk beds. Kitchenette (4 hot plates, mini-oven). Bathroom, sep. WC. Electric heating. Balcony, south facing position and south-west facing position. Terrace furniture. Beautiful view of the mountains and the valley. Maximum 1 pet/ dog allowed. The apartment is situated in building B.
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 020 8544 7114 for prices for other travel
and room options for this property.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


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Borobudur : A Wonder of Indonesia History
Home » Borobudur: A Wonder of Indonesia History » Find Hotel » Mutiara Hotel
Mutiara Hotel
Hotel Mutiara Malioboro is a three star hotel placed strategically and welcomes guests with attentive hospitality.
Located on the vibrant Malioboro Street in Yogyakarta, Hotel Mutiara Malioboro is a place of elegance and warmth. Hotel Mutiara is only 15 minutes drive away from the airport and merely 5 minutes away from the main Railway Station.
Jalan Malioboro No. 18
Yogyakarta, Java 55213 PO Box 1087
The location of the hotel makes it easy for tourists to visit some of the interesting places like the government quarters and the Sultan Palace with ease as these attractions are situated at walking distance from the hotel.
Yogyakarta has many attractions, culture treasures and shopping centers. The popular Borobudur or Prambanan temples are also accessible from the location of the hotel easily.
There are over 119 rooms at Mutiara Malioboro, Yogyakarta equipped with most of the modern amenities. Each of the rooms is spacious, nicely decorated with marble bathroom. The interiors are all done is the traditional Javanese style. Most of the rooms offer wonderful views of the city.
The excellent central location, make Hotel Mutiara Malioboro the ideal choice for stay in Yogyakarta.
Various room types available at Hotel Mutiara Malioboro include:
North Wing Standard
South Wing Superior
South Wing Deluxe
South Wing Junior Suites
Hotel Mutiara Malioboro provides various room facilities such as individual air conditioning, private bathroom, IDD telephone, color TV with Satellite connection, in-house movies, mini bar and working desk.
Like other comfortable three star hotels, Hotel Mutiara Malioboro also presents varied amenities that the guests can enjoy during their stay. The guests at Mutiara Hotel can enjoy a dip in the fresh water of the swimming pool at the hotel. Tourists can also choose to spend some good time at the Lounge Bar at the hotel or indulge in a delicious fare at the restaurant at Hotel Mutiara.
Other facilities available include 24 hours room service, Taxi Service and out door Swimming Pool. There are several restaurants and bars for dining and drinking namely, Tiara Restaurant, Mirah Restaurant, Sekaten Bar &lounge and lastly the Pool Bar.
For the benefit of the business travelers, the hotel organizes conference and meeting facilities. The hotel is equipped with most of the necessary amenities required for business purpose. Some of the facilities include Over head projector, screen, White board, Flip chart, Sound and Wireless, Ice water and candy, Memo pad and so on. Other things like TV 20 - 35 inches, VHS Video, LCD, Computer and Photo Copy Machine are also available
|Jln. Malioboro 18 Yogyakarta 55213
|(0274) 563814


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Latest download from MiniCap web page: http://www.donationcoder....Mouser/MiniCap/index.html
v1.32.01 - Mar 22, 2014
- [BugFix] Fixed rare screen zoom bug.
v1.31.01 - Aug 17, 2014
- [BugFix] Region capture sizes were off by one.
- [MinorFeature] Main window now shows on taskbar (when main window is shown).
- [MinorFeature] Image dimensions are now shown on main window.
- [MinorFeature] Selection is cleared after new captures.
- [BugFix] Image starts out blank if MiniCap launched with no commandline parameters.
- [Feature] Updated with new scrolling capture code from big brother tool Screenshot Captor.
- [MinorFeature] Previous foreground window is restored after exit.
- [Feature] New commandline option to embed (exif) comment in file (gif, png, jpg, pdf, tiff, but not .bmp format).
- [Feature] New commandline option to not focus a target window when doing a window capture.
v1.28.01 - Nov 29, 2013
- [MinorFeature] Added -capsound commandline option to play sound after capture.
- [Major Feature] Updated with latest Screenshot Captor scrolling window capture code.
- [Feature] Now offering both installer and portable zip downloads; executables and installer are now signed.
v1.25.01 - Nov 13, 2011
- [MinorFeature] Added -dpi option to set DPI of saved image.
v1.24.01 - Aug 28, 2011
- [MinorFeature] Updated with current Screenshot Captor semi-transparent window Aero capture abilities
- [MinorFeature] Better reporting of failure-to-save-file errors.
v1.23.01 - Oct 21, 2010
- [MinorFeature] The file extension (.exe) is removed from the captured application filename ($fullfilename$)
- [MinorFeature] You can now use $uniquenum0$ instead of $uniquenum$ if you want to force a counter name always even if not needed to avoid conflict with existing file.
v1.21.01 - 6/7/10
- [BugFix] The -exit commandline option was not being obeyed if user used -print but didn't save.
v1.20.01 - 5/4/10
- [Feature] Updated with latest Screenshot Captor capture code.
- MajorFeature] Completely re-rewritten new method for capturing Aero Glass themed Semi-transparent windows on Vista and Windows 7. Based on an approach described by Ian Griffiths (http://www.interact-sw.co...g/2007/01/30/recoveralpha), with several tweaks for automatic border detection and improved color handling. A new options tab ("Windows Capturing") was added to control the various options for it. Note that by default SC will preserve the entire transparency recovered from the window; this will allow you to composite the screenshot in graphics editing software with it's original semi-transparent regions and effects. By default SC will attempt to remove the shadow effect imparted by Aero, but you can change this via commandline options.
- [BugFix] Was refusing to capture certain windows like Google Chrome; errors in capturing are now reported better.
v1.18.01 - 12/25/2009
- Added commandline options for grayscale and black+white conversion.
v1.17.01 - 12/25/2009
- Added commandline options for printing.
- Added print button.
- Hitting Escape key in main form will now exit.
v1.16.01 - 3/12/2009
- Added commandline options for resizing
v1.15.01 - 12/08/2008
- Added commandline option -postrun "commandline" to run a post processing program on the captured image (use $file$ to replace saved image filename in commandline)
v1.14.01 - 10/05/2008
- Improved capture of non-standard (skinned) windows, for example bblean.
- Added hotkey Ctrl+U to unselect region.
v1.13.01 - 08/15/2008
- Added commandline option -captureactivewin which will capture whatever window was last active before triggering minicap.
- Added grabbing of last active window application name for filename replacement with $appname$
- Extension is removed from $appname$
- You can now combine -promptsave with -save to have minicap prompt you to change the filename initialized to that specified with -save
v1.12.01 - 07/30/2008
- Added commandline option -promptsave to ask user for filename and do a save after capture.
- Modified behavior so that the -exit commanline parameter will cause an exit after a manual save.
v1.11.01 - 07/24/2008
- Added new more flexible way to specify custom date text wherever you want in your commandline
v1.10.01 - 07/23/2008
- Added new capture modes (screen, redbox object, redbox region, traditional region)
- Remembers last save directory better.
- Added options to copy images (or saved file path) to clipboard.
- Added border/shadow option.
v1.08.02 - 07/05/06
- Fixed lingering issue with ghosted gridlines showing when scrolling capture from IE.
If run on the commandline without any arguments, MiniCap starts up in interactive capture mode (identical to redbox capture mode in screenshot captor); select the object to capture, hit control click, and it will appear in preview. Hit Save As to save the file.
But the most common way to use the program is with commandline arguments for non interactive capture:
-save "OUTPUTFILENAME"
Tells MiniCap to automatically save the captured image using the specified filename, including path, and extension which should include the image format extension of your choice (.jpg, .gif, .pdf, .png, .bmp, .tiff).
You can use certain fields which will be replaced:
$appdir$ - application directory (useful if you want to save snapshot in same directory)
$appname$ - application exe name (without path)
$nicename$ - nice name of application exe (taken from exe resource)
$windowtitle$ - window caption
$uniquenum$ - adds unique number to filename to avoid overwriting existing files (number only added when needed to avoid existing file)
$uniquenum0$ - adds unique number to filename to avoid overwriting existing files (number ALWAYS added)
$datetime$ , $date$ , $time$ - local date/time
$dt:%DATEFORMATSTRING$ - where DATEFORMATSTRING is made up from the following:
%a Abbreviated weekday name
%A Full weekday name
%b Abbreviated month name
%B Full month name
%c Date and time representation appropriate for locale
%d Day of month as decimal number (01 – 31)
%H Hour in 24-hour format (00 – 23)
%I Hour in 12-hour format (01 – 12)
%j Day of year as decimal number (001 – 366)
%m Month as decimal number (01 – 12)
%M Minute as decimal number (00 – 59)
%p Current locale's A.M./P.M. indicator for 12-hour clock
%S Second as decimal number (00 – 59)
%U Week of year as decimal number, with Sunday as first day of week (00 – 53)
%w Weekday as decimal number (0 – 6; Sunday is 0)
%W Week of year as decimal number, with Monday as first day of week (00 – 53)
%x Date representation for current locale
%X Time representation for current locale
%y Year without century, as decimal number (00 – 99)
%Y Year with century, as decimal number
%z Time-zone name
%Z Time-zone abbreviation
Tells the app that is run to close after screenshot is taken
If you don't specify -closeapp or -killapp then the app will be left running after the app is launched
Closes app harshly if it won't close by normal request
-sleep #
Sleep # seconds before engaging capture
Capture current screen
Capture entire desktop workspace (all multimonitors if more than one exists)
Automatically capture the application specified by a -run argument
-capturehwnd #
Automatically capture the window with the specified handle number (specified in decimal)
-capturepid #
Automatically capture the main window of the application with the specified process id (specified in decimal)
-captureregion left top right bottom
Capture screeen region specified
Interactive capture of region (traditional style mode -- locked to current screen of multimonitor)
Interactive capture of region (red box mode)
Interactive capture of object (red box mode)
-captureappbyname "filename.exe"
Find the window of the running exe specified and capture it (specify filename with extension but no path)
Capture last active window
Exit minicap after the screenshot is saved
If you don't specify this then MiniCap will remain open after the capture.
Use scrolling window capture more
Set window to be captured to foreground before capturing
Captures client area of the window, useful when capturing windows which have no borders/titlebar
-run "APPNAME" [args+]
Runs a specific application specified before capturing.
All arguments after appname are passed on the commandline to the app, so -run needs to be the last argument you specify
-runcap "APPNAME" [args+]
Same as calling with -run and automatically adds the following arguments for easy use:
"-closeapp -exit -sleep 3 -captureapp"
Like -run, this needs to be the LAST arguments you specify
-postrun "COMMANDLINEWITHARGS"
runs a program after the image is saved (use $file$ to replace saved image filename in commandline)
-compress #
Set compression quality from 1 to 10 (10 is highest quality and biggest image); default to 8
Copy the image to clipboard after capture
Copy the saved image filename (full path) to clipboard after capture
Add a nice border and shadow to image
Asks user for filename to save immediately after a capture.
If combined with a filename specified using -save "FILENAME" then you will be prompted to save as with the filename pre-filled out.
-resizexp PERCENTAGE
resize x dimension to PERCENTAGE% of its original value (y will be scaled to preserve ratio if no y resize value specified)
-resizeyp PERCENTAGE
resize y dimension to PERCENTAGE% of its original value (x will be scaled to preserve ratio if no x resize value specified)
-resizex WIDTH
resize x dimension to exactly WIDTH pixels (y will be scaled to preserve ratio if no y resize value specified)
-resizey HEIGHT
resize y dimension to exactly HEIGHT pixels (y will be scaled to preserve ratio if no y resize value specified)
print the captured image
show a print preview before printing and allow adjustment of margins, etc.
-setprinter PRINTERNAME
sets a specific printer for printing (to get a list invoke -setprinter list); you can use the full name or a substring
-convert CONVERTMODE
CONVERTMODE is from:
bwo = Black+White (ordered)
bwf = Black+White (floydSteinberg method)
bwt = Black+White (local threshold)
bwt1 = Black+White (global threshold of 128)
bwt2 = Black+White (global threshold of avg pixel)
btw3 = Black+White (global threshold set by entropy)
gray = Grayscale
disables the new aero capture mode even on vista/win7 machines
-aeroborder THRESHOLD
THRESHOLD should be an integer from 0 to 255
if set to 0 then no automatic shadow removal/border trimming will take place, and a larger image with the aero shadow will be captured.
a higher value, like 200, will attempt to clean up the borders and result in small image dimensions by removing bordering pixels with alpha values smaller than that specified.
-aerocolor COLORCOMPONENTVALUE
COLORCOMPONENTVALUE should be an integer from 0 to 255
if you specify 0 you will get a black background when flattening (see below), if 255 then a white background when flattening
flattens the area inside the border so that the image has only 2 levels of transparency -- purely transparent outside the border (see option above), and purely opaque inside the border region. the -aerocolor parameter specifies the background color to merge transparency with when flattening.
-dpi VALUE
sets the DPI value in the image properties of the saved image (useful when importing images into MS word, printing, etc.
play a capture sound after every capture.
do not switch to target window when capturing specific windows.
-comment "comment string here"
embed (exif) comment in saved file (works on png, jpg, tiff, gif, but not .bmp)
MiniCap.exe -save "C:\screen_$appname$$uniquenum$_$date$.jpg" -closeapp -exit -sleep 4 -capturerunapp -run "C:\Program Files\Macromedia\FlashPlayer.exe" "C:\MyMovie.swf"
MiniCap.exe -capturerunapp -exit -save "D:\desktop.png" -sleep 5 -closeapp -exit -run "C:\WINDOWS\system32\notepad.exe" "C:\WINDOWS\test.txt"
-save "E:\test.jpg" -runcap "C:\WINDOWS\system32\notepad.exe" "C:\WINDOWS\test.txt"
look forward to hearing your feedback!


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Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
Recently having undergone a complete refurbishment, the Chalet Camarine has a modern and bright feel throughout.
Built in traditional style, this freestanding chalet sits just above Chalets Victoria and Camelia in this popular part of Méribel - just outside the bustling village but within 10 minutes' walking distance of the centre. Ideal for couples or groups who may enjoy the peace of the location but also easily take advantage of the lively village charm. The cosy lounge has a wonderful open log fire creating a warm atmosphere for evening relaxation in which to swap stories of the day! For access to the ski lifts we offer a complimentary minibus service every morning and afternoon.
En suite private facilities throughout.
Ground Floor
Entrance, Lounge, Dining room, ski & boot room, wc.
Room 1: Twin with bath/wc.
First Floor
Room 2: Triple (sleeps 2-3) with bath/wc.
Room 3: Twin with shower/wc/balcony.
Room 4: Twin with bath/wc/balcony.
Second Floor
Room 5: Quad room (sleeps 2-4) with bath/wc, under eaves
"Free wine included worth over €100".
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 020 8544 7114 for prices for other travel
and room options for this property.
The price shown includes 7 nights accommodation,
with flights from Gatwick.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


text:
Main Nibbles
Main Page
Articles & Reviews Of Foods
From A To Z
Product Reviews
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Home Page
Link to Other Sections:
Newsletter, Marketplace,
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Last Updated August 2015
Here's a food glossary (food dictionary) for almost every occasion: a collection of food terms in specific areas. Consider these as "food lover's guides" for areas of your passion, or areas you'd like to learn more about. These quick and easy reference glossaries are more than food dictionaries: Many are packed full of information and historical reference, and are fascinating reading.
Use the Contact Us link on this page to recommend a new glossary topic.
*Asterisks indicate our Top 10 most popular glossaries.
What's the difference between a bonbon and a truffle? Look it up in the Chocolate Glossary. Photo above of Chocolat Moderne, a NIBBLE Top Pick Of The Week.
What are the different grades of maple syrup and which should you buy? Check the Maple Syrup Glossary.
Alaea Hawaiian volcanic salt is one of dozens of exciting artisanal salts that add new dimensions of flavor to food. Discover the others in our Salt Glossary.
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text:
Gifts for Baby Girls
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Girl Farm Fannies Down-Home Diaper Cover by Baby Aspen
The Girl Farm Fannies Down-Home Diaper Cover will bring a smile to baby and mama's face with it's cuteness! Features include:
SIZE: 0-6 months
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text:
Commack man accused of driving drunk into school bus with kids aboard
COMMACK - A Commack man is under arrest after police say he drunkenly drove into a school bus full of kids this morning.
Police say Robert Slavonik, 44, hit a bus from the Three Village School District on Route 25A in Smithtown before driving away. A witness reported Slavonik's license plate to police, who arrested him at his home.
The students aboard the bus were not hurt. Slavonik is expected to be arraigned tomorrow.


text:
Super Bright LED Light
Price: $9.95
Super Bright LED Light high tech, portable light provides bright light when you need it. Attaches to almost any surface and the 28 LED extra -wide beam lights up an entire room. Use it as a hanging light, flashlight, or work light. The magnetic, kickstand base, built-in hook and sturdy design provide hands-free use options. Use as a lamp or switch to the 4 LED torch lite mode. As seen on TV Durable construction.Uses3 AAA batteries (not included). Perfect for power outages, camping, outdoor activies, anywhere you need light! A must have for any tool kit, emergency kit, car or RV.


text:
Luminescence-based cell-based assay to identify inhibitors of NADPH oxidase 1 (NOX1)
Host defense mechanisms are diverse and include receptor-initiated signaling pathways, antibody and cytokine production, and the generation of reactive oxygen species (ROS) such as hydroxyl radical and hypochlorus acid to kill microorganisms (1). In activated phagocytic cells, the membrane integrated protein gp91phox serves as the catalytic cytochrome b subunit of the respiratory burst oxidase more ..
BioActive Compounds: 68
Related Experiments
Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC)
Center Affiliation: The Scripps Research Institute, TSRI
Assay Provider: Gary Bokoch, TSRI
Network: Molecular Libraries Probe Production Center Network (MLPCN)
Grant Proposal Number: 1 R03 MH083264-01A1
Grant Proposal PI: Gary Bokoch, TSRI
External Assay ID: NOX1_INH_LUMI_384_3X%INH
Name: Luminescence-based cell-based assay to identify inhibitors of NADPH oxidase 1 (NOX1).
Host defense mechanisms are diverse and include receptor-initiated signaling pathways, antibody and cytokine production, and the generation of reactive oxygen species (ROS) such as hydroxyl radical and hypochlorus acid to kill microorganisms (1). In activated phagocytic cells, the membrane integrated protein gp91phox serves as the catalytic cytochrome b subunit of the respiratory burst oxidase used to generate superoxide in an NADPH-dependent manner for host defense (2). Generation of ROS has also been identified in non-phagocytic cells (3). One important enzyme involved in ROS production in non-leukocyte tissues is NADPH oxidase 1 (NOX1), a homolog of gp91phox. NOX1 is highly expressed in colon epithelial cells where it can generate ROS to interact with normal and pathogenic bacteria (3-5). However, excess ROS production is associated with damage to the intestinal mucosa, particularly in mucosal lesions of inflammatory bowel disease (IBD) (4). Studies showing that NOX1 levels are increased in human prostate cancer (6) and that cells overexpressing NOX1 have a transformed appearance, exhibit anchorage-independent growth, and induce vascularized tumor formation in athymic mice (3, 7), suggest that NOX1 may also play a role in angiogenesis, cell growth, and tumor pathogenesis (8, 9). The identification of inhibitors of NOX1 may lead to potential candidates for excess cell proliferation, cancer, and IBD.
1. Takeya, R. and Sumimoto, H., Molecular mechanism for activation of superoxide-producing NADPH oxidases. Mol Cells, 2003. 16(3): p. 271-7.
2. Cheng, G., Cao, Z., Xu, X., van Meir, E.G., and Lambeth, J.D., Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene, 2001. 269(1-2): p. 131-40.
3. Suh, Y.A., Arnold, R.S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A.B., Griendling, K.K., and Lambeth, J.D., Cell transformation by the superoxide-generating oxidase Mox1. Nature, 1999. 401(6748): p. 79-82.
4. Szanto, I., Rubbia-Brandt, L., Kiss, P., Steger, K., Banfi, B., Kovari, E., Herrmann, F., Hadengue, A., and Krause, K.H., Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol, 2005. 207(2): p. 164-76.
5. Rokutan, K., Kawahara, T., Kuwano, Y., Tominaga, K., Nishida, K., and Teshima-Kondo, S., Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol, 2008. 30(3): p. 315-27.
6. Lim, S.D., Sun, C., Lambeth, J.D., Marshall, F., Amin, M., Chung, L., Petros, J.A., and Arnold, R.S., Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate, 2005. 62(2): p. 200-7.
7. Arnold, R.S., Shi, J., Murad, E., Whalen, A.M., Sun, C.Q., Polavarapu, R., Parthasarathy, S., Petros, J.A., and Lambeth, J.D., Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci U S A, 2001. 98(10): p. 5550-5.
8. Ushio-Fukai, M. and Nakamura, Y., Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett, 2008. 266(1): p. 37-52.
9. Kobayashi, S., Nojima, Y., Shibuya, M., and Maru, Y., Nox1 regulates apoptosis and potentially stimulates branching morphogenesis in sinusoidal endothelial cells. Exp Cell Res, 2004. 300(2): p. 455-62.
NOX1, NADPH oxidase 1, cancer, inflammation, 384, inhibitor, inhibition, late stage, HT29, luminol, ROS, chemiluminescence, Scripps, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Center Network, MLPCN.
Assay Overview:
The purpose of this cell-based assay is to confirm activity of compounds of interest identified as active in the primary assay. This chemiluminescence assay employs a luminol probe to monitor intracellular ROS in the HT29 transformed colonic epithelial cell line. HT29 cells express high endogenous levels of known NOX1 components and no other Nox family members.
Protocol Summary:
In this assay, the cells are incubated with test compounds for one hour, and then cell permeable luminol and horseradish peroxidase are added. The interaction of luminol with NOX1-generated ROS/superoxide inside cells yields an unstable endoperoxide that generates light, leading to increased well luminescence. As designed, compounds that inhibit cellular NOX1 activity will reduce intracellular ROS and endoperoxide levels, leading to reduced luminol-ROS interactions, reduced endoperoxide production, reduced light emission, and reduced well luminescence. Test compounds were assayed in triplicate at a final nominal concentration of 3.3 micromolar.
PubChem Activity Outcome and Score:
Compounds with ≥50% inhibitory activity were scored as "Active", and compounds with < 50% inhibitory activity were scored as "Inactive". The reported PubChem Activity Score has been normalized to 100% observed primary inhibition. Negative % inhibition values are reported as activity score zero.
The PubChem Activity Score range for active compounds is 100-47, for inactive 44-0.
List of Reagents:
HT29 cells (provided by Assay Provider)
DMEM medium (GIBCO, part 25200)
Hank's Balanced Salt Solution (Invitrogen, part 14025-092)
100X Penicillin-Streptomycin mix (Invitrogen, part 15140)
Trypsin-EDTA solution (Invitrogen, part 25200-056)
Fetal Bovine Serum (Invitrogen, part 16140-071)
Luminol (Sigma, 09253-5g)
Horseradish peroxidase (EMD Bioscience, part 516531-5KU)
DPI (Sigma, D2926)
150 mm tissue culture dishes (Corning, part 430599)
384-well plates (Corning, 3704)
Possible artifacts of this assay can include, but are not limited to: dust or lint located in or on wells of the microtiter plate, compounds that non-specifically modulate luciferase activity, and compounds that quench or emit luminescence within the well. All test compound concentrations reported are nominal; the specific concentration for a particular test compound may vary based upon the actual sample provided by the MLSMR.
Categorized Comment - additional comments and annotations
From PubChem:
Assay Format: Cell-based
Assay Cell Type: HT-29
Result Definitions
** Test Concentration.
Additional Information
Grant Number: 1 R03 MH083264-01A1
Data Table (Concise)


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Starbucks isn't the only one dabbling in pumpkin spice.
8 No-Cook Appetizers For Your Thanksgiving Spread
Upgrade the classic cheesecake by adding the flavors of a seasonal favorite: the spiced pumpkin latte!
Recipe: Spiced Pumpkin Latte Cheesecake
Apple pies get all the attention in fall. Why not bring a little excitement to the classic fall ingredient by making a rustic and beautiful crostata instead?
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Baby bump fashion flops and rumored pregnancy weight gain were the hot topics of the moment when "omg! Insider" correspondent and "Yo Show" host Michael Yo, sat down with reality royalty Kim Kardashian at the junket for her upcoming film, "Tyler Perry's Temptation."
Kim addressed the headlines head-on. "It says that I'm like 200 pounds on there. That's like, definitely a good 60 pounds off," she laughed. She also poked fun at her very-changed pregnancy diet saying, "What's so funny is I love junk food and I love fast food, I love sweets. I haven't been able to eat any of that since I've been pregnant," going on to say, "I'm craving like carrots and celery with ranch."
The weight gain rumors weren't the only thing she set the record straight on. She also set cleared the air about a leather skirt that some deemed 'too tight', saying, "It's a maternity skirt that I had made." She also insisted, "They have pregnancy spanx that are tighter than the skirt I'm wearing."
Watch the video to find out more of the rumors Kim K laid to rest and don't forget to tune in to "omg! Insider" on TV Monday night for Michael Yo's entire revealing interview with the Kardashian.
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