text:
Student Learning Outcomes
Student Learning Outcomes
TRANSFER CENTER STUDENT LEARNING OUTCOMES (Fall 2012 – Spring 2013)
A. TAG SLO: By the end of a counseling session or workshop on TAG, students will gain knowledge and understanding of the process of completing a TAG online, of the minimum GPA and course requirements, deadlines and of the differences and similarities among UC Campus requirements. (Fall 2012)
B. ENGN 10A SLO: By the end of the presentation by a transfer program counselor to students enrolled in Engineering 10A, students will have gained accurate knowledge about the requirements to transfer as an Engineering major to a UC, CSU, or private college or university. (Fall 2012 & Spring 2013)
C. UNIVERSITY APPLICATION SLO: By the end of the workshop, students will gain knowledge and understanding of the process of completing a university application including the application websites, deadlines minimum transfer eligibility requirements, academic reporting requirements, and the university notification timeline. (Fall 2012)
Caution: The final responsibility for a successful transfer program
rests with the student. This information changes frequently and can
impact your admission to the university. It is highly advised that
you meet periodically with counselors at City College AND advisors
at the university to confirm your choice of classes and educational plan.
| Calendar
| Latest
News and Deadlines | Services
| Transfer
Basics | FAQ
| Glossary
| Alumni
News | Student
Learning Outcomes | Quick
Links | Meet
Our Staff | Contact Us |

subset: commoncrawl


text:
Fire Resistant
How Safe Is Your Child's Halloween Costume?
Halloween costumes must meet federal flammability standards, but it doesn't mean they won't burn. With the help of the Holiday Park Fire Department, KDKA-TV's Susan Koeppen set several costumes on fire – all of them are currently on store shelves and were purchased from various retailers.


text:
ResolutionLicense number has the same format for all products and consists from the three paths. The first is the product identifier: PLSK for Plesk, SB for Sitebuilder, VZ for Virtuozzo, HSPC for PBAS (formerly HSPcomplete) and EXP for Expand. The second eight digits path is unique one and actually it is the license number. And the four digits third path is the number that indicates how many times the license was updated, upgraded and renewed.
It is always important to know the full license number if you contact Parallels support. How to find the license number for Parallels server products is described in the articles below:
Parallels Plesk Control Panel
Parallels Cloud Server
Parallels Virtuozzo Containers for Linux
Parallels Virtuozzo Containers for Windows
Parallels Plesk Sitebuilder for Linux/Unix
Parallels Plesk Sitebuilder for Windows
Parallels Plesk Expand
Parallels Business Automation - Standard
Parallels Plesk Automation
Parallels Web Presence Builder


text:
|Women's Soccer » News » Schedule » Roster » Coaches » Statistics
Buccaneer Soccer releases 2003 schedule
Tuesday, April 08, 2003JOHNSON CITY, Tenn. (April 8, 2003) - East Tennessee State University head women's soccer coach Heather Henson has released the Buccaneers 2003 soccer schedule. The Buccaneers will have eight home games in 2003, with six of those being conference matches. The non-conference schedule includes dates with David Lipscomb and Austin Peay at the Lady Gov Classic, Belmont, Radford, UNC Asheville, and Winthrop. In 2003 ETSU will host the Southern Conference's newest member, Elon University, the Phoenix will travel to Johnson City on October 24 for the 7:00 contest. "We are playing a few teams that we have not played before," Henson said. "I think that this schedule will be a good challenge for us and one that we will be ready for." The 2003 campaign will also mark the first time the Southern Conference has had teams from each of its member institutions (12) competing for the SoCon Championship. ETSU will open up the season on Aug. 29 as they travel to Clarksville, Tenn. for the Lady Gov Classic where they will take on David Lipscomb at 4:30 CST. The Buccaneers first home game will be Sep. 5 as they host Belmont at 7 p.m. at the Liberty Bell Soccer Complex.
Women's Soccer Archives
2002-03 Women's Soccer


text:
And it's so easy! If you can put a tube over the candle, you can do the trick!
Magically change the color of a candle, then turn the candle into a beautiful feather flower bouquet! Show the white candle (light it if you want- that is optional). Then simply slide the slim metal tube over the candle for a moment, and when you lift the tube off, the candle has changed colors- it's now a RED candle!
But wait! Now put the tube over the red candle, and when you remove the tube, the candle has VANISHED and turned into a BOUQUET OF RED FLOWERS!
Absolutely NO SKILL required! If you can slide the tube onto the candle, you can do this trick! It's all self-contained- the trick practically performs itself! Couldn't be easier- or more spectacular!
Perfect for a talent show or theatrical production, as it can be performed by almost anyone. Adds lots of color and surprise to your magic act. Best of all, the bouquet can be left in view for the remainder of your show- makes your show look more "magical"!
PLEASE NOTE: The color of the tube may be golden brass color (as in the product photo), or dark red (as in the demo video), depending on what the manufacturer is currently shipping.
The flower is a feather flower, and is similar to the Blooming Blossom and the Drooping Flower tricks. Use all three in your routine, then leave them out on your table during the rest of your act. The colors make your show look bigger!
Feather flowers like these are made from REAL turkey feathers, dyed and tied into flower shapes. With a bit of care, these feather flowers will easily last for many years of use.
Store your feather flowers OPEN. In other words, don't wrap them up and store them. Prop them up in a vase or other container, and drape a light cloth over them to keep the dust off.
DO NOT wash your feather flowers. You can lightly shake them, or use canned air or a hair dryer (on the "COOL" setting) to remove dust.
You can also use a hair dryer on "COOL" to fluff up the flowers.


text:
Eau De Toilette
by Joop!
WFor Women
Item #
Free Shipping in U.S. (orders over $59.00)
- Design House: Joop!
- Fragrance Notes: florals, vanilla, and sandalwood, sweet and feminine.
- Year Introduced: 1987
- Recommended Use: romantic
No reviews written for this product
1 - 5 (of 5 Reviews)
I have been wearing Joop! for Women every day & eve for the past 25+ years. Most people I am near comment, "Your scent is lovely. What are you wearing?" People who know me typically say, "Gee, you smell just like you." Even when I kissed my mother goodbye every morning or night she'd say, "Oh, you smell so good," knowing I still was using Joop! for all these years. Joop! for Women is my scent and mine alone. It feels as if it were made only for me. I have not bothered to try any other scent, as there is nothing else that suits me so well. The scent of Joop! defines me as does my jewelry & pearls that I wear. Nothing could ever compare to Joop! for me.
Written by K. Reagan, M.D. on April 02, 2015Read Review details ►
I have buying Joop for Women for my daughter for quite a few years now. She loves the smell and receives many compliments on it. It is light, playful, sexy, subtle, and everything good about a fragrance. I am so happy that this company sells it because the U.S. retailers do not carry it or I cannot find it!! You cannot go wrong with Joop!!
Written by Mary on December 15, 2014Read Review details ►
This is a scent that you have to know where you are going and how it will affect the ones you will come in contact. Like leaving a lasting impression! I like wearing it to church and ministry events. If you perspire it will carry you until you get home. I did not see it much in the store but when I came to this website I put the name in the search bar and I found it again. I simply love this fragrance!
Written by Maria on August 31, 2014Read Review details ►
Joop is my go-to fragrance. It lasts forever on me too. I love the spicy aroma.
Written by jotroup on August 26, 2014Read Review details ►
Since the first time I was introduced to this perfume, I have always loved it. It's a perfect mix, so not too soft and not too strong.
Written by M.Nano on August 22, 2014Read Review details ►
1 - 5 (of 5 Reviews)


text:
Description:24A Model - MPDU 24A Low Voltage Option Part# 252663-D71
Overview:Compaq is a leading global provider of information technology products services and solutions for enterprise customers. Compaq designs develops manufactures and markets information technology equipment software services and solutions including industry-leading enterprise storage and computing solutions fault-tolerant business-critical solutions communication products personal desktop and notebook computers and personal entertainment and Internet access devices.
Part Number252663-D71
Products ID141912
Form FactorRack-Mountable
Total Number of Outlets32 Outlets
Audible AlarmWithout Audible Alarm
Cable Length12 ft
Dimensions (WxDxH)17.5 in x 5.6 in x 1.62 in
Weight18 oz


text:
January 16, 2011
Aquafina, a Grade 1-placed full sister to champions Ocean Runaway and Wave Carver, earned the first victory of her career in the $26,000 AQHA Maiden Stakes on Sunday at Hialeah Park. The 300-yard race was restricted to Bank of America Challenge-enrolled horses who were maidens at the time of nomination on December 22. The race card was contested under great conditions with partly cloudy skies and a fast main track.
Entering the starting gate, it appeared Aquafina had the field over the barrel, with speed indices and lifetime earnings far exceeding anything put forth by her other nine rivals.
Leaving the starting gate from post 10 as the even-money favorite, Aquafina broke well and gradually moved inside a lane or two under Francisco Ramirez Jr. Drawn on the rail, 11-1 longshot Prince Nemo took his best shot, ending up on the lead, with Aquafina in touch from the outside. In the final 150 yards, class prevailed, and Aquafina wore down Prince Nemo to win by three-quarters of a length with Dive In a half-length back in third.
The 3-year-old daughter of First Down Dash earned a 94 speed index for her time of :15.431 and picked up $15,600 for the win to push her earnings to $109,057. Although a maiden through her first eight starts, Aquafina finished third in the Sam Houston Futurity (G1) and second in the Hialeah Lassie Futurity. She also qualified to the Texas Classic Futurity (G1).
Bred in Maryland by owner Lucas Racing Inc., Aquafina is one of 16 winners out of the remarkably productive mare Runaway Wave. An AQHA Dam of Distinction and the 2005 AQHA Broodmare of the Year, the 16-year-old daughter of Runaway Winner has produced the earners of more than $3.4 million.
Now with just three days to go in the season, racing resumes at Hialeah Park on Friday with a 2:05 p.m. first race post. The final three days of the live American Quarter Horse season at Hialeah Park will be good ones with five stakes scheduled. On Saturday, January 22, fans have a chance to win part of $2,500 with the free "Hialeah Handicapping Challenge." In addition, the track will offer an All Stakes Pick 4 on the Saturday card with racing highlighted by the $60,000-added South Florida Quarter Horse Derby. The track will showcase Cuban superstar Rey Ruiz free in-concert on Sunday, January 23, closing day. In addition, fans in attendance will receive a free Hialeah Park t-shirt, while supplies last. The closing day feature is the $60,000 Hialeah Invitational, which is expected to come up very, very tough. The second racing season at the historic oval ends on Sunday with a special 12:35 p.m. first race post. Hialeah Park offers free parking and admission every day, with valet parking available for just $3.
See more AQHA Partner benefits


text:
29 April 2010
Posted in Employment
Frequently Asked Questions
About how long does it take to get a call back after you email an application in?
Due to the volume of applications that we receive, we are not able to respond to individual calls or emails regarding the status of your application.
How much do both FT and PT employees get paid?
If it is not posted, compensation is discussed at the time of the interview.
How do I apply for a job?
Do I need to indicate what position I am applying for?
Human Resources will process applications and resumes for current job openings only. Applicants must specify the job title on applications, resumes, and cover letters to assure proper handling. Unsolicited applications and resumes are not accepted, i.e. applications for "any" or "open" positions are not kept on file.
What are your benefits?
For Full Time benefited positions: Health benefits (health, dental, vision), long-term disability, life insurance, employer matched savings plan, credit union, flexible vacation days. For Part Time & Full Time employees: Annual family membership, free covered parking, complimentary OSC tickets, direct deposit, discounts in café, store, and on programs.


text:
The Wall Street Journal reported earlier tonight that Microsoft–in what would be its most aggressive acquisition in the digital space–was zeroing in on buying Skype for $8.5 billion all in with an assumption of the Luxembourg-based company's debt.
Sources told BoomTown tonight that the deal for the online telephony and video communications giant is actually done and will be announced early tomorrow morning.
The purchase–which has been spearheaded in closely held negotiations by Microsoft CEO Steve Ballmer, with an assist from top dealmaker Charles Songhurst–is a bold move for the software giant and its biggest acquisition in more than three decades.
This deal is utter madness. Microsoft's only option to make this deal work is to monetize Skype (and its other VOIP services) in ways that Skype itself already knows will only lead to alienation of its users, and a mass exodus from the service. Despite all the reliable sources confirming this story, I still find it hard to believe that even Ballmer is this dumb, or this desperate.
Apple, with their strong presence in mobile and Facetime, must be turning backflips right now. Not to mention the other existing VOIP companies out there (who have always had Skype as their main competitor), including Google.
The big price will give Microsoft–which has struggled in its online efforts and has lost billions of dollars for its work–a big brand name on the Web.
With Skype, which has been aggressively expanding, Microsoft will continue to lose money in its Internet efforts. Skype lost $7 million on revenue of $860 million. Operating profits, which Skype preferred to highlight, were $264 million.
And–let us not forget–Skype's debt is $686 million. Silver lining: That's slightly less than Microsoft's Online Services division losses in its most recent quarter!
But, sources said, the concept is bigger than just money, including getting access to Skype's 663 million registered users.
From All Things D
Are we really expected to believe that Microsoft is paying $13 per registered Skype user, and assuming all the companies debts to boot?
Good luck with that. Skype is simply going to disappear, along with a huge chunk of Microsoft's remaining cash hoard and credibility.
The only good thing to come from this is that Ballmer will finally be ousted from the company.
UPDATE : Bloomberg are reporting that Skype only has around 170 million active users. Which would mean that Microsoft could be paying around $52 for each of them!


text:
Description:HP Pentium III/P1400 DL380 G2(1.4GHz/Single-core/133MHz/512KB)Full Processor Option Kit w/VRM and HeatsinkPart Number(s)Option Part# 201099-B21
HP Processor Kits:
Manufacturer Part# 201099-B21
This is the full processor option kit. It includes the
Processor(s), Heat-Sink(s), Fan(s), Thermal paste
and VRM (Voltage Regulator Module) where required.
Overview:This Intel Pentium III processor option kit working at 1130MHz with 512KB of cache is designed and manufactured by Intel for the HP Proliant DL380 G2 servers.
Genuine Compaq Full Warranty.
CategoryProliant Processor
Part Number201099-B21
Products ID1226
Product TypeProcessor Upgrade
Processor TypeIntel Pentium III Processor
Processor CoreSingle-Core
Processor Qty1
Clock Speed1.40GHz
Bus Speed133 MHz
L2 Cache512KB
Processor SocketSocket PGA-370


text: Cornhole Tournament July 27th beginning at 10am at Brown Middle School, 1140 Kendall Mill Road in Thomasville. Pre-registration required, $20 registration per team. Contact Jerry Wayne 336-971-039 or Stephanie 336-225-6658 to register. There will be kids activities, raffles, cycling event begins at 8am, food, and much more. Proceeds benefit the American Cancer Society Relay For Life of Davidson County.


text:
Victor Lord Park DG course has been listed as extinct on DGCR.
There were some emails from me to the Director of Parks and Rec concerning the course. He stated (at that time) that the course would HOPEFULLY be redesigned and new baskets installed. Obviously ain't gonna happen...kinda sad to see any course go away, especially one that was close by...RIP VLP


text:
The reason for the question is that I have a friend with an iPhone who sends emoticons, and I receive them as a single rectangular box. I wonder if it's an encoding problem.
Take the 2-minute tour ×
Android Enthusiasts Stack Exchange is a question and answer site for enthusiasts and power users of the Android operating system. It's 100% free, no registration required.
iPhone emoticons are not character combinations like
By using some third party sms apps such as GO SMS PRO and installing its Emoji Plugin you would be able to send and receive such iPhone emoticons to/from your friend.
SMS, generally, uses the 7-bit GSM encoding standard, however a quick cursory glance with google-fu yielded this answer posted on StackOverflow which seems to say that Apple uses UTF-16 (Unicode encoding).
This would explain why you got a rectangular box as the handset is not able to decipher the encoding.
You can find out more here as per the standards document


text:
Here I am on the scale this morning. The three colored markers are Green: Safe, Yellow: Caution and Red: Dangerous. I need to lose 15 pounds just to be in the Danger zone! And the holidays are here. It ain't gonna be pretty…
That scale is too accurate! :) If all else fails, there's always the New Year's resolution.
Check out Seeing Things !


text:
Bags > Iris Hobo
Sale: $66.75
Reg: $89.00
Iris Hobo
model #: 104622
Classic and easy to carry, the Iris hobo is the perfect companion to take you from work to the weekend. Freshen up your wardrobe with one of our new shades!
- special web price $89, regular price: $129
- Exterior: Leather with polyurethane trim
- Interior: Polyester
- hardware varies by color: antique silver tone or antique brass tone hardware
- 13.5in L x 5in W x 11in H Drop 13.75in
- Zipper Closure
- Front outside pocket with zipper closure
- Lining features two multi-use pockets and a zippered back wall pocket
- Clean with a water-based leather cleaner and moisturizer. Use a protective spray to protect the leather surface
- Origin: Imported
You must be logged in to write a review.
Wednesday September 17 2014
I have had several sak bags! They are top quality and this is also! It is soft and fits my stuff perfectly and also a great price!
Wednesday September 17 2014
Just rec'd my bag yesterday, and I love it! It is roomy, and has nice soft leather! A great price also! Saw the same bag in a major retailer and it was $60 more!!!
Wednesday March 12 2014
Love this bag.... Big but not too big.....roomy interior and good pockets too! All of this and its great looking to boot!


text:
Starting from
East Tower Classic Two Doubles
What Makes This Room Different
Located in our East Tower, the Classic Room offers 2 double beds. Features include 32" TV with Pay-Per-View movies, iron/board, hair dryer, and private voice mail.
Room Features
Room Amenities
Square Footage : 318-504
Smoking/Non-Smoking : Both
Refrigerator : Small portable refrigerators (upon request, based on availability)
Workspace : Desk/table with two chairs
Furniture : Modern
Window Treatments : Sheers and blackout drapes
View : Mountain
Decor : Modern
Sheets : 300 thread count
Bath Products : Yes
Vanity : Yes
Makeup Mirror : No
Tub/Shower : Yes
In-Mirror TV : No
Shower Head : Standard
Robes : No
Hair Dryer : Yes
In-Mirror TV : No
Phone : No
Alarm Clock : Yes
Iron w/ Board : Yes
Coffee Maker : No
Television : 32" TV, Nintendo entertainment system
Telephone : Yes, private voice mail
DVD Player : No
iPod Stereo : No
CD Player : No


text:
|Publication number
|Publication type
|Application number
|Publication date
|Nov 29, 2007
|Filing date
|Jun 20, 2007
|Priority date
|Jan 21, 1992
|Also published as
|Publication number
|Philip Green
|Original Assignee
|Sri International
|Export Citation
|BiBTeX, EndNote, RefMan
|Referenced by (3), Classifications (47), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation of U.S. patent application Ser. No. 11/015,212 filed Dec. 16, 2004; which is a continuation of U.S. patent application Ser. No. 08/709,930 filed Sep. 9, 1996 (now U.S. Pat. No. 6,963,792), which is a continuation of U.S. patent application Ser. No. 07/823,932 filed Jan. 21, 1992 (now abandoned), the fall disclosures of which are incorporated herein by reference.
This invention relates generally to teleoperator method and apparatus, and particularly to those which include means for providing the operator of remote apparatus with the same sense as working directly with his hands at the worksite.
Teleoperating, which is well known, includes the human performance of tasks at a remote location using manipulators. Telepresense includes providing the teleoperator with the same feedback and control that he would have were he actually at the worksite carrying out the operation with his own hands. Telepresence operation generally includes use of a stationary visual display, particularly a stereographic visual display of the remote workspace. Stereoscopic television systems are well known as shown, for example, in U.S. Pat. Nos. 4,562,463 and 4,583,117 and in U.K. Patent Application GB 2,040,134.
Remote manipulators employing stereoscopic TV viewing together with force feedback also are well known as shown, for example, in an article entitled, "Controlling Remote Manipulators Through Kinesthetic Coupling," Bejczy et al, Computers in Mechanical Engineering, July 1983, pps. 48-60, and in an article entitled, "Stereo Advantage for a Peg-In-Hole Task Using a Force-Feedback Manipulator" by E. H. Spain, SPIE Vol. 1256 Stereoscopic Displays and Applications, 1990, pps, 244-254. In the Bejczy et al. article) force-torque feedback is disclosed. Also, in U.S. Pat. No. 3,921,445, a manipulator which includes force, torque and slip sensors of a type which may be employed with the present invention is shown.
Even though the operator of prior art manipulators is provided with a stationary three-dimensional image of the workspace, and manual controllers for control of the manipulators are provided with feedback, the operator is not provided with a sense of actually being present at the worksite. The present invention is directed to a viewing arrangement for use in a remote manipulation system which substantially adds to the operator's sense of presence at the remote manipulator site.
An object of this invention is the provision of an improved teleoperator system and method which include an improved viewing system to enhance the operator's sense of presence at remote manipulators controlled by the operator from a remote location.
An object of this invention is the provision of an improved teleoperator system and method of the above-mentioned type wherein an image of manipulator end effectors for viewing by the operator are sensed by the operator as comprising an integral part of hand-controllers used by the operator to control the end effectors, thereby giving the operator a strong sense of presence at the worksite.
An object of this invention is the provision of an improved teleoperator system and method of the above-mentioned type which is well adapted for use in a wide variety of applications including military, industrial, biomedical, and the like.
The present invention includes manipulators located at a worksite and which are controlled by hand-operated means at a remote operator control station. End effectors at the manipulators are used for manipulating objects located in a workspace at the worksite, and force-torque feedback is employed for transmitting back to the operator mechanical resistance encountered by the end effectors. Stereographic visual display means provide the operator with an image of the workspace. In accordance with the present invention, the image is located adjacent the hand-operated means so that the operator looks in the direction of the hand-operated means for viewing the image adjacent the hand-operated means. Either a real or virtual image of the workspace may be provided adjacent the hand-operated means. Display means for display of a real image may be located adjacent the hand-operated means for direct viewing of the real image by the operator. For display of a virtual image of the workspace, a mirror is located between the operator's eyes and the hand-operated means. In this case, display means provide a real image which is inverted from top to bottom, which inverted image is viewed via the mirror, which mirror inverts the image and provides the operator with a virtual image of the workspace, which appears to be located adjacent the hand-operated means. By locating the image of the workspace adjacent the hand-operated means the operator is provided with a sense that the end effectors and hand-operated means are substantially integral despite the fact the end effectors are located at the worksite and the hand-operated means are located at the remote operator's station. A stereophonic sound system may be included to provide the operator with stereophonic sound from the worksite. Video camera means are provided for viewing the workspace from which an image of the workspace is obtained. Various other sensors and associated responders may be located at the worksite and operator's station, respectively, for transmission of pressure, tactile, heat, vibration and similar information for enhanced telepresence operation.
Depending upon the application, different scaling may be provided in the transmission of information between the operator's station and worksite. For example, for microassembly, microsurgery and like operations involving small part manipulation, optical and/or video magnification may be employed to provide an enlarged 3-dimensional image for viewing by the operator. With similar scaling between the hand operated means and manipulators, the perception of the operator is substantially that which a miniature operator would have were he at the worksite.
The invention, together with other objects and advantages thereof will be better understood from the following description considered with the accompanying drawings. It will be understood that the drawings are for purposes of illustration and example only, and that the invention is not limited thereto. In the drawings, wherein like reference characters refer to the same parts in the several views,
Reference now is made to
Arm 34R includes telescopic inner section 34R1 and outer section 34R2, which outer section is adapted both for axial movement into and out of inner section 34R1 and for rotation about its longitudinal axis. An end effector 40R is carried at the outer end of the arm which, for purposes of illustration, is shown to comprise a gripper. Motor means, not shown, control pivotal movement of arm 34R about pivot axes 36 and 38, axial and rotary movement of outer arm section 34R along and about the longitudinal axis of the arm, and opening and closing of gripper 40R. The motor means, together with motor control circuits for control of the motors, may be included in housing 32R. The motors are under control of a computer 42 connected thereto through right manipulator interface 44R and the above-mentioned motor control circuits.
The left manipulator 24L is of substantially the same design as the right manipulator 24R and the same reference numerals, but with the suffix L instead of R, are used to identify similar parts. For purposes of illustration, the left end effector 40L, shown in
The worksite is provided with a pair of video cameras 46R and 46L for viewing workspace 30 from different angles for production of stereoscopic signal outputs therefrom at lines 48R and 48L. The angle γ between the optical axes of the cameras shown in
The video camera outputs at lines 48R and 48L are supplied to an image memory 50 for momentary storage of video fields of right and left images from the cameras. Fields of right and left images from image memory 50 are alternately supplied through left/right switch means 52 to visual display means 54, such as a television monitor, for alternate display of the two images at the face 54A of the monitor. Timing and control means 56 provide timing and control signals to various elements of the system, including elements included in the stereographic display system, for signal timing and control of the system. If digital storage means 50 are employed, then conversion of the camera signal outputs to digital signal form by analog to digital converter means prior to storage, and conversion of the digital signal output from left/right switch means to analog signal form in preparation for display at monitor 54 may be employed.
An electrooptical device 58 at the face of the display means 54 controls polarization of light received from display means 54 under control of a left/right synchronizing signal from timing and control unit 56. The left and right image fields are viewed by operator 18 wearing a pair of passive polarized glasses 60 having right and left polarizing elements 62 and 64 polarized in orthogonal directions. The polarization of light from display 54 through electrooptical device 58 is synchronized field by field such that the right field is occluded from the left eye and the left field is occluded from the right eye for stereographic viewing by the operator. Other means for stereographic viewing of left and fight image fields are well known, including, for example, those using active stereographic glasses) which may be used in the practice of this invention to provide the operator with a stereoscopic view of the remote workspace.
The vertical deflection coil connections for monitor 54 are reversed, causing the monitor to scan from bottom to top thereby creating a top-to-bottom inverted image 30I of workspace 30. Letters a, b, c and d are used to identify corresponding corners of the workspace 30 and inverted workspace image 30I. The inverted workspace image 30I is viewed by the operator via a mirror 66 at the top of a table 68, which mirror inverts image 30I to return the image as viewed by the operator to an upright position. Looking downwardly in the direction of the mirror, the operator views a virtual image 30V of workspace 30. In accordance with one aspect of the present invention, the image viewed by the operator, which in the
Controller means 70 are shown located beneath the table top 68 and include right and left controllers 72R and 72L for control of the respective right and left manipulators 24R and 24L. The right and left controllers are of substantially the same design so that a description of one applies to both. As with the manipulators, the suffixes R and L are used to distinguish elements of the right controller from those of the left controller. For purposes of illustration, and not by way of limitation, the right controller 72R is shown to comprise a housing 74R affixed to the bottom of table top 68 and from which hand-operated means 76R in the form of a telescopic control arm, or stick, extends.
The right and left control arms 76R and 76L are provided with the same degrees of freedom as the associated manipulator arms 34R and 34L, respectively. For example, the inner end of control arm 76R is mounted for pivotal movement about a horizontal pivot axis, corresponding to manipulator pivot axis 36, which axis, in turn, is adapted for pivotal movement about an intersecting vertical axis, corresponding to manipulator axis 38. Control arm 76R also includes inner section 76R1 and outer section 76R2, which outer section is adapted both for axial movement into and out of inner section 76R1 and for rotation about its longitudinal axis. It will be apparent that the control arm 76R is provided with the same four degrees of freedom as the associated manipulator arm 34R. Additionally, sensor means 78R are located adjacent the outer end of outer arm section 76R2 for use in controlling gripping action of gripper 40R. Similar sensor means 78L adjacent the outer end of control arm 76L are adapted for use in controlling operation of scissor blades 40L.
Right and left controllers 72R and 72L are included in a servomechanism system wherein mechanical motion of control arms 76R and 76L controls the position of manipulator arms 34R and 34L, and pressure on sensor means 78R and 78L controls opening and closing of end effectors 40R and 40L, respectively. In
Reference now is made to
Between elements of the worksite and operator station, the following relationships pertain:
a+b=kL, (1)
d=kD, and (2)
g=kG (3)
where k is a scale factor constant.
When k equals 1 such that a+b=L, d=D and g=G, no scaling of worksite dimensions is required.
Any scale factor may be employed, the invention not being limited to full-scale manipulation. For example, the worksite can be small, including microscopic in size, in which case the optical parameters, including distance to object, interocular distance and focal length, and mechanical and dimensional parameters are appropriately scaled.
By using appropriate scaling and image magnification and force and torque feedback, and by locating the image 30V of the workspace 30 adjacent hand-operated control means 76R and 76L, the operator is provided with a strong sense of directly controlling the end effectors 40R and 40L. The operator is provided with a sense that the end effectors 40R and 40L and respective control arms 76R and 76L are substantially integral. This same sense of togetherness of the hand-operated control means and end effectors is not provided in prior art arrangements wherein the image viewed by the operator is not located adjacent the hand-operated control means. Even where the prior art includes stereoscopic viewing and force and torque feedback, there is a feeling of disconnectedness of the hand notions from the visual image object being worked upon. The present invention overcomes this sense of disconnectedness by locating the workspace image where the operator's hands appear to exercise direct control over the end effectors.
For small-scale manipulation, such as required for surgical applications, it is desired to replicate the visual experience that a miniature observer would have were he closely adjacent the actual worksite. In
Reference now is made to
The manipulators include outer control sections 100RA and 100LA and insertion sections 100RB and 100LB, which insertion sections are adapted for insertion into a body cavity through cylindrical tubes, or cannulas, not shown. For purposes of illustration, the manipulators are shown inserted through the abdomen wall 106 of a subject. As is well understood, for laparoscopic surgical procedures, wall 106 is separated from internal organs by insufflation wherein a gas is introduced into the abdomen by any suitable means not shown. Manipulator motors and associated motor control circuits are contained in the outer control sections 100RA and 100LA of the manipulators for control of the insertion section. The manipulators, together with a laparoscope 103 for viewing organs within the cavity, are carried by a fixed rail 110 forming part of a surgical table upon which the subject is supported.
The insertion sections 100RB and 100LB of the manipulators may be of substantially the same design as manipulator arms 34R and 34L described above with reference to the
Laparoscope 108 for viewing the workspace 104 is shown comprising an outer operating section 108A and insertion section 108B. The outer end section 120 of insertion section 108B is axially and rotatably movable within the inner end 122 thereof, and is provided with a pair of image transmission windows 124, 124 for stereoscopic viewing of workspace 104. The laparoscope also is provided with illuminating means, not shown, for illuminating the workspace, and with liquid inlet and outlet means, not shown, for flow of liquid past the windows. Video camera means within section 108A are responsive to light, received through the viewing windows for generation of left and right electronic images at output lines 48R and 48L for connection to image memory 50. A magnified 3-dimensional image 1041 is produced at display means 54 for viewing by the operator wearing cross-polarized classes 60 via mirror 66. As with the embodiment shown in
With the
The present invention is not limited to use with manipulators having any particular number of degrees of freedom. Manipulators with different degrees of freedom which are well known in the art may be used in the practice of this invention. In
A control arm 150L comprising inner and outer sections 150L1 and 150L2, respectively, is mounted within housing 144 for pivotal movement in any pivotal direction as indicated by intersecting double-headed arrows 152 and 154. The outer section 150L2 is adapted for axial movement into and out of inner section 150L1 in the direction of double-headed arrow 156. It also is adapted for rotation about its longitudinal axis in the direction of double-headed arrow 158. In this embodiment, the control arm includes an end section 160 pivotally attached to outer section 150L2 by wrist joint 162 for pivotal movement in the direction of double-headed arrow 164. End section 160 comprises axially aligned inner and outer sections 160A and 160B, the outer section 160B of which is rotatable about its longitudinal axis in the direction of double-headed arrow 166. As with the above-described arrangements, sensor means 168 are located adjacent the free end of the control arm for operation of an end effector 170 at manipulator 142 shown in
Referring to
The outer operating end of the manipulator is adapted for attachment to a supporting rail, not shown, of the surgery table upon which the subject is supported. It includes an end effector drive motor 182 for opening and closing of gripper 170. Wrist drive motor 184 controls pivotal movement of wrist 172 in the direction of double-headed arrow 164M, and extension drive motor 186 controls axial movement of manipulator arm 174 in the direction of double-headed arrow 156M. Forearm pivotal control motors and linkages, identified generally by reference numeral 188, provide for pivotal movement of arm 174 about pivot point 176 in the directions of arrows 152M and 154M. Pivotal motion about point 176 is provided by simultaneous lateral movement of the outer operating end of the manipulator and pivotal movement of arm 174. Movements are coordinated such that the center of rotation of forearm 174 is fixed in space at point 176 at the level of the abdominal wall.
Controller 140 and manipulator 142 are included in a system such as shown in
Reference now is made to
Reference now is made to
The invention having been described in detail in accordance with requirements of the Patent Statutes, various other charges and modifications will suggest themselves to those skilled in this art. For example, as noted above, the invention may include the use of tactile feedback to provide the subtle sensations for palpation and for manipulating tissues and instruments. To provide this feedbacks tactile sensor arrays may be included on the end effectors which are coupled to tactile sensor stimulator arrays on the hand-operated control means, which reproduce the tactile sensation on the operator's hands. A variety of transduction technologies for teleoperator tactile sensing are known including resistive/conductive, semiconductor, piezoelectric capacitive and photoelectric. Hand-operated control means and manipulators of different types may be employed using a wide variety of well-known mechanisms and electromechanical elements including, for example, gimbals, linkages, pulleys, cables, drive belts and bands, gears, optical or electromagnetic position encoders, and angular and linear motors. Force feedback to the operator requires use of body contact with hand-operated control means. Both hand grip type hand controllers such as those illustrated, and control brace type hand controllers are well adapted for use with the present invention for force feedback to the operator. Control brace hand controllers include use of structures with positive sensors mounted on the operator at joints for measuring joint angles. Force feedback then can be applied to each joint. Similarly, light fabric gloves with variable-resistance or fiber-optic flex sensors mounted on the joints for measuring bending of individual fingers may be used. Gloves of this type also may be provided with force feedback to provide for telepresence interaction with real objects. Regardless of the type of hand-operated control means employed, an image of the workspace is produced adjacent thereto to provide the operator with a sense that the end effector means and hand-operated control means are substantially integral. Also, as noted above, servomechanisms of many different types are well known in the robotic and teleoperator system arts, and the invention is not limited to any particular type. Those that include force and torque feedback to the operator are preferred to contribute to a telepresence sense of operation. In addition, many different means for producing a stereoscopic image of the workspace are known. For example, instead of using two cameras, a single camera may be employed together with switched cross-polarizing elements in the image receiving path. In this case, a pair of spaced stereoscopic lenses are used for viewing the workspace from different angles and providing first and second images thereof to the camera. In the
|Citing Patent
|Filing date
|Publication date
|Jul 11, 2006
|Jun 19, 2012
|Catheter Robotics, Inc.
|Remotely controlled catheter insertion system
|Mar 18, 2011
|Mar 18, 2014
|Catheter Robotics Inc.
|Remotely controlled catheter insertion system
|Apr 15, 2009
|Oct 21, 2010
|Kuka Roboter Gmbh
|Method for providing force-feedback for interaction of user with prototype of vehicle, involves introducing force-feedback into handling device using robot arms, utilizing deformable object, and influencing object-current shape by arms
|U.S. Classification
|606/170, 700/251, 606/167
|International Classification
|Cooperative Classification
|European Classification
|Jul 12, 2011
|Certificate of correction
|Sep 26, 2014
|Maintenance fee reminder mailed
|Feb 15, 2015
|Lapse for failure to pay maintenance fees
|Apr 7, 2015
|Expired due to failure to pay maintenance fee
Effective date: 20150215


text:
Somebody tried to steal my 2003 ford F350 this moring, couldn't get it started though tried to cut out my alarm system, starter kill kicked in. So truck is still there, now all I have to do is get another ignition lock.
No damage other than a couple wires off my siren and the ignition lock.
Right in front of my house, didn't hear the siren go off.
Thanks to the last guy who had his welding truck ripped off, a day later I had a full system installed!
Results 1 to 10 of 32
Thread: Somebody tried to steal my truck
Somebody tried to steal my truck
11-18-2008, 11:48 AM #2Senior Member
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- Feb 2006
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- 3,711
I am glad they did NOT get your truck! Thieves are usually ruthless. Sounds like you had it pretty well secured. I hope there are a few extra precautions you can take in case they come back.
I know how you feel. I had a '68 factory stock Chevy Camaro stolen out of driveway. I never even heard them. This was many years ago and alarms were really not heard of-at least from what I remember.
Good luck fixing her up. A few wires and ignition should not be a big deal. Again good luck on repairs and thank goodness it was not stolen.
Apparently he or they got in by the drivers door, just twisted the lock on the door open, solved that today by removing both door locks and installing door handles like I have on my back doors without the lock mechanism, never used them anyways. Can't get through my back window as there is cargo rack bars in the way.
Now they either have to smash a window, or tow it.
Never the less the automatic starter kill is handy.
Man... thats stinks, glad they failed, i often worry about my cables being grabbed, we had a run of thefts here, people were breaking in to houses and cutting out the copper pipes for scrap! I had some guy steal 2,200lbs of new aluminum from my shop... i bought cameras the next day... long story short, he came back and i bagged him, now he's trying to say that he's the victim, because he had to pay restitution... makes no sense!Kelly
Trailblazer 301D
2 XMT 304's
Dynasty 300 Tigrunner
Spectrum 2050
XR with ALUMA-PRO
12RC suitcase
Millermatic 251
60a feeder
Ellis 1600
16" southbend
Too many Hand tools...
An extra relay run off a switch to kill the power to the fuel pump is also another helpfull and hide-able way to slow them down too.
Most all of my cars have some weird security that i've built where you must turn something on to get starter power or a hidden switch that kills a relay that i added to the fuel pump system.
this won't stop a tow truck, but it will slow down your average car thief enough to usually frustrate them out of taking your ride.Dynasty 200DX
Hobart Handler 135
Smith MB55A-510 O/A setup
Hypertherm Powermax 45
Just about every other hand tool you can imagine
80% of failures are from 20% of causes
Never compromise your principles today in the name of furthering them in the future.
"All I ever wanted was an honest week's pay for an honest day's work." -Sgt. Bilko
"We are generally better persuaded by reasons we discover ourselves than by those given to us by others." -Pascal
"Since we cannot know all that there is to be known about anything, we ought to know a little about everything." -Pascal
11-18-2008, 09:43 PM #7Senior Member
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I dont understand how you replaced your door latches. Do have a pic or two?Who do you call when the lawmakers ignore the law?
Miller AC/DC Thunderbolt 225
Miller 180 w/Autoset
Old cutting torch on LPG
11-19-2008, 12:30 AM #8Senior Member
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really glad you still have the truck. looks like the system payed for its self after all, never have to wonder if it was worth it now.thanks for the help
hope i helped
feel free to shoot me an e-mail direct i have time to chat. firstname.lastname@example.com
summer is here, plant a tree. if you don't have space or time to plant one sponsor some one else to plant one for you. a tree is an investment in our planet, help it out.
11-19-2008, 07:00 AM #10Senior Member
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- Sep 2007
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- Medford MA
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Glad they didn't succeed.
As the economies turn down, we'll have more and more of this.
Just a few weeks ago, someone went around to all the
unlocked cars in my neighborhood and cleaned them out
of loose change, GPS's, etc. They were very nice, they
didn't break into any cars or do any damage -- but
if it wasn't nailed down, it was theirs...


text:
Halfmoon cut on the end of a piece of pipe like this >>>>>>>>> ) Thanks all!
Results 1 to 10 of 18
02-02-2008, 12:36 PM #1Member
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- Jan 2008
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- 33
How do you make a....................
Hole saw, plasma cutter, o/a torch, grinder with grinding disc or cutting disc, depending on wall thickness - tin snips, nibbler, pipe notcher, and probably others.
Hardly enough info to give a definitive answer.
02-02-2008, 12:52 PM #3Junior Member
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- Jan 2008
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- calgary
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- 9
cutting curves
in the past i have made a jig and used a hole saw of the same size as the tubing to cut the curve
( take a block of wood , put the tube on it and nail side rails on to hold the pipe between them, then drill a hole the correct size near the end. flip it over with the pipe under the hole where you want the hole and drill it out with the hole saw. just be careful that you have a block of wood under it to save the hole saw from getting damaged.) the end of the pipe has the curve!!
Like what? i don't see a picture am i missing something? i guess you are referring to a saddle? if it is small pipe like 11/2''or 2'' i set my chop-saw at 25deg. and cut off a centerline, anything bigger i use my wrap-around and lay it out with a soap stone. i hope this helps.
if you are talking about bigger pipe they make attachments to go on saddle bevellers to make thos types of cuts, otherwise there is the grinder and torch to make the cutsmm210
maxstar 150
02-02-2008, 04:33 PM #6Member
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- Jan 2008
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- 33
The arrows here are pointing to the kind of cut i'm talking about > ) < I guess you could do it on any size pipe. I guess you could call it notching the end of the pipe so you can weld it to another piece.
I'm a little confused by what you are asking for, but I'll take a stab at it and guess that you are trying make templates to cope pipe.
To save a bunch of long winded explanations, I'll give you a quickie shortcut that will serve your purposes:
Follow this link to the HarderWoods site. Fill out the pipe information on the left column, and it will generate templates for you. Print them out onto paper, and transfer them to cork or paper gasket material, cut them out and you are ready to go. I myself, have used this software to make templates for some oddball stuff, and then I transferred them over to a flexible, thin, magnetic material that I have which holds it to the pipe quite nicely.
The only information you will need is pipe O.D. and wall thickness, and if you have it closeby, just use a tape measure, or I can supply you a link to pipe schedule charts. Mathey Dearman used to have a good one.
I have built several grill guards, winch guards and head ache racks for Class 8 semis using coped pipe, so I will offer you a word of wisdom: Measure your pipes VERY carefully.....When you transfer over your measurement to the pipe to be cut - lets say (for example) that 15" is what you need - remember that the 15" is from the BOTTOM of one coped joint, to the BOTTOM of the other coped joint. DON'T FORGET to add the 15/16" (for example) to accomodate the depth of the cope for each end when you lay out your cut lines. After you cut the pipe, then use your templates to chalk out the copes, and the bottom to bottom measurement should be 15".
Hope this helps.
On Edit: I see that you are on WW under the username "Metal Man", asking the same question, so I'll copy & post this over there as well. Don't know which site you view more.Later,
Professional Spark Generator by Trade.
put the pipe in a chop saw and cut 1/2 the end off at a 40% angle then flip it over and do it again. you will end up with a saddle (see pic)
you can alter the % to acomodate non 90% intersections.
quick and easy.thanks for the help
hope i helped
feel free to shoot me an e-mail direct i have time to chat. firstname.lastname@example.com
summer is here, plant a tree. if you don't have space or time to plant one sponsor some one else to plant one for you. a tree is an investment in our planet, help it out.
02-02-2008, 08:06 PM #9Member
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- Jan 2008
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- 33
Easy as pie!!!!!! Thanks alot for the info and pic! .....Tim
02-03-2008, 07:20 PM #10Senior Member
- Join Date
- Feb 2006
- Posts
- 411
Hey James,
I like that info....neet
. Thanks for sharing with us


text:
Rush Select Archive
Rush Soccer forms select teams comprised of top Rush players from across the country to attend various events on a yearly basis. Player pools are established through club recommendations and identification at the Rush Festival. Players can move in and out of the player pool based on their current form. Select Team coaches have the final say in which players make the roster for any particular event.
2013 Rush Select Nominiations Announced
(11.17.12) The first ever Rush Select ID camp is underway in Casa Grande, AZ. The top 31 U14B's and the top 37 U13B's arrived in Casa Grande on Friday afternoon, and after taking a "luxury" bus from Phoenix airport to Casa Grande, wasted no time in getting the camp underway. Rush Select Director Nik Penn, was joined by Head Coach Brian Lux (Pikes Peak Rush) and assistant Kevin Driggs (NM Rush) with the B14 group and Head Coach Andy Vanover (DE Rush) and assistants Adam Ritchie (MD Rush) and Charlie Raphael (MD Rush) with the B13 group.
The purpose of the camp is to help identify and train the players to make the traveling squad for the annual Rush Select event at the Presidents Day Tournament in Phoenix on February 2013. The first training session started at 4:00pm on Friday and the boys were back out there at 7:30pm to play the first 11v11 games under the lights. The Select Staff are able to have all their needs taken care of at the Casa Grande resort, with 8 immaculate fields (6 lighted), hotel and banquet facilities as well as classroom, locker room and meeting rooms.
Saturday saw the boys back out after breakfast for a morning training session, which was followed by watching the LA Galaxy vs. Real Salt lake U18 Academy game before heading in to lunch. The boys had the pleasure of speaking with two former Rush players that are now part of the residency program for Real Salt Lake here at Casa Grande, and hearing about their experience and what it takes to become an Academy Player. The afternoon saw a second training session of the day, and the evening back to 11v11 under the lights and a second classroom session.
Players coming from 18 Rush Clubs are represented in Arizona, all looking to join the event in February. Sunday will see the final day of training and games before they all head back to their home states. For updated information please go to the Facebook/rushselect for photos and updates.
Rush Select G14 – Rush Fest 2012
The U14 Rush Select girls completed their 5 day training camp in Virginia Beach on Tuesday July 17th. The girls represented Colorado, Tennessee, Maryland, Wisconsin, Texas, New Mexico, Wisconsin, New York, respectively.
Steve Davis, NY Technical Director, and Chris Panayiotou, Rush WI Youth Director had the privilege of coaching the team. Steve and Chris would like to thank all the parents and everyone involved in the event that helped make it a huge success. Thanks to the drivers, chaperones and girls, along with Kendra Austin and Nik Penn, for their help and guidance, and to Adam Logan, who makes things happen with his camera.
The girls spoke at opening ceremony of the U12 Rushfest and shared what playing for Rush Select meant to them.
The girls had 3-4 activities a day. Some were training sessions, some were games and some were class room sessions with a balance of taking in Virginia Beach's culture.
The girls played VA Rush U15 ECNL team and after being 1-0 up with a goal from Hannah Crooks (MD) with possibly her 3rd or 4th touch and moments after going on. VA Rush drew level with a goal against the run of play early in the second half. After some adjustments U14 Select regained control and further goals from Corinne Burns (NY), Bree Bezdek (CO) and a brace from Delainee Evans (CO) saw Rush Select run out 5-1 winners.
The next day Select played against the VA Rush U14 ECNL team and in difficult conditions ran out 1-0 winners with a well taken goal from Corinne Burns (NY) with the assist coming from Bree Bezdek (CO).
The final game saw Rush Select split themselves into two teams with 6 players from the U16 VA ECNL team. The intra squad scrimmage saw some great football and ended in a 1-1 draw, with Bree Bezdeck (CO) scoring and Catie McDonald (NM) scoring the equalizer in an entertaining game.
Quote from one the parents:
"I also wanted to thank you for the great time... I really enjoyed getting to know the girls and both you and Coach Steve. It was truly a pleasure to watch such talented girls play soccer together. Oh yeah, and to watch such talented coaches guide them.... Thank you again for letting me be a part of that."
(07.11.12) Rush Select is preparing to again attend the Rush Fest, this time to be held by Virginia Rush in Virginia Beach. The G14 Select, with Chris Panayiotou (WI Rush) moving up from assistant to take the head coach role assisted but Steve Davis (NY) will be taking a pool of 20 players to Virginia Beach for a four day camp in conjunction with the Festival. The girls will be taking on the VA Rush ECNL teams with the group of players taken from 9 different states as well as joining in with some of the Fest activities, such as the BBQ and the Beach Soccer.
The B14 Select, coached by Dave Dengerink (TX) will not be traveling to the Fest this year as they just returned from a very successful trip to Alaska, where they won the Alaska Airlines Cup in the B16 bracket. The Girls will be looking to repeat the feat of a 100% record at last year's Fest, playing a year up.
At the U13 level, Stuart Fitzsimons (TX Rush) will be taking a group of 25 players to the U14 Fest to test their skills a year up. The team will train as a group with Stuart and assistant Dan Highstead (PP Rush) as well as join in the Festival festivities. Andy Machin (WA Rush) will be traveling with a group of B13 Select the same week to play up at the B14 age group.
The Festival provides a unique opportunity for Select players across the country to actually get together and train as a team and give the coaches a chance to input their ideas and Rush philosophies to the players.
You can follow the teams by going to the Rush Select Facebook page for updates.
B14 Select to compete in Alaska Airlines Cup
The very successful B14 Rush Select team will be traveling to Alaska at the beginning of June to compete in the Alaska Airlines Cup in Anchorage. The team that has won back to back Presidents Day Tournaments in Phoenix, along with a record of 4-0-0 playing up at the Rush Fest last summer in Albuquerque, is hoping to extend their winning ways this time around.
Lead again by head coach Dave Dengerink (TX) and this time assisted by Nik Penn (PP) and Tim Schulz (Rush Soccer), the team will pit their skills up a year for increased competition. Below you will see the boys that are competing, coming from eight different states.
|Robert Frusina
|Nick Cullen
|Dylan Greco
|Ryan Mouldenhauer
|Jeron Cunningham
|Michael Swift
|Nick Toupin
|Zach Emerson
|Hunter Hayden
|Jesse Riggs
|Sean Halverson
|Payton Miller
|Kelly Walters
|Drew Spink
|Paul Matyas
|Sam Buzzas
You will be able to follow the guys progress through the Rush Select Festbook page at www.facebook.com/rushselect
(02.21.12) Phoenix, Arizona, Presidents Day Tournament. Rush Select teams wind up last day of competition. Story of the day is the U14 Boys. Champions!!! Yes, these young men played like warriors. A crowd of 200 plus came to watch a wonderful performance and three goals to boot. "The team was terrific! Early today we had a heart to heart as we barely squeaked through in the Semis. I don't care if it was the semi's or a friendly. They did not play well and I let them know about it," commented Coach Dave Dengerink. Dave currently coaches at Texas Rush. One of the first employees in Rush Soccer history, he is no stranger to championships. His resume is impressive winning a multitude of National Championships and producing numerous pros under his tutelage. Dave displayed many of the Rush Core values including Tenacity. "My job is to get a little more out of them every time they step on the field. I am not interested in coasting, whining or excuses."
The GU13 PDT lost in the semi-finals against the Scottsdale Blackhawks 1-0. "Extremely proud to be associated with the seventeen young ladies and their families who represented the Rush Select at the PDT 2012. Tough, tenacious and unified throughout, the work ethic of the group is fantastic. They gave all to the cause and deserved a little more luck in the semi-final. The loss in the semi-final will only spur this group onto bigger things next year. We certainly look to the future with great purpose with the goal of going one further next year," commented Coach Stuart Fitzsimons from Texas Rush.
The GU16 PDT Rush team lost 1-0 to Sparta out of Utah. Ben John Technical Director of Wisconsin Rush adds, "While the outcome was disappointing, since winning the championship was our singular goal, the girls did an outstanding job of competing and accounting for themselves. They left it all out on the pitch and I am extremely proud of their individual and collective effort."
All in all a great weekend for the Rush Select teams.
(02.20.12) Phoenix, Arizona, Presidents Day Tournament. Rush Select Team Director Nik Penn, "It is a bittersweet day. Although we are happy for the four teams that got through, we feel for the teams that missed by such a small margin." Of the four teams that made it to the quarters, the G15 lost a heartbreaker in the quarters in a PK shoot outs. "These girls played outstanding. This game is cruel. We came back from two goals down and to dominate play only to loss in PK's is disappointing," Matt Middelstaedt says moments after the shootout. "I am speechless…all I can say is that I am very proud of these girls."
Three teams playing in the semi's tomorrow, Monday.
Ben John of Wisconsin Rush is Head Coach of the GU16.
Dave Dengerink of Texas Rush is Head Coach of the BU14.
Stuart Fitzsimmons of Texas Rush is Head Coach of the GU13.
Tomorrow will wrap up day four for the Rush Select Teams. Three teams will all kick-off at 8:30am mst.
Game 1
Game 2
Game 3
B13 Lux
Lost in Pks
*dnq = Did Not Qualify
(02.19.12) Phoenix, Arizona, Presidents Day Tournament. Rush Select teams take to the field in opening day competition. "I am very pleased with our overall results," says PDT Director Nik Penn. Nik oversees the Rush Select teams across the U.S. which is no easy task. Rush is in 25 states and growing. "Yes, it is difficult. Comparing one player 2,000 miles away 2 months ago to another player, on different conditions in different circumstances is a challenge. Regardless it is worth it. Seeing these kids from different backgrounds and cultures, yet all from Rush Soccer, coming together with one common goal is very special."
The Rush has nine Select teams playing in the tournament with an overall record for today of 10 wins, 4 losses and 4 ties accounting for 29 goals for and 13 goals against.
Game 1 score
Game 2 score
Player of day per Team
Chey Mattos
B13 Lux
Hunter Wiebel
Payton Miller
John Finucan
Chase Clack
Amanda Porter
Corrine Burns
Emily Marsh
Rachael Estopare
(Bold names are Male and Female player of day winners for all Rush Teams.)
Dehai Abraham from Florida Rush representing the U13 Boys Select says, "Yes, I am happy with our two games, very happy. Our first game we lost, but played decent. The second we won and seemed to jell even more." When asked his overall all impression of PDT, "Everybody is very skilled, and perform at a high level of intensity…it is great to be here."
Rush continues play tomorrow to determine which teams go through to the play rounds.
(02.18.12) Day one was a day for getting introduced to each other and getting the kinks out of the legs. Most players arrived late yesterday, Thursday. There was excitement in the air as the players met their teammates most for the first time. "This is what Nationals go through all the time," says Nik Penn Director of Select Teams for Rush Soccer. "This specific program (PDT or Player Development Teams) focuses on bringing our more passionate elite Rush players from around the U.S."
The Rush currently have 25 clubs in the U.S. to make up the select teams. This is a mechanism to bring like players with like talents together. "There are many objectives," continues NIk, " The players get a chance to play more then they would with there respective clubs. The players then take there experience and new found knowledge back to the clubs to pass on the message."
Last year, Rush faired fairly well at this event winning two championships and placing a couple more in the semi's. As the Rush Clubs grow and evolve, the talent gets better and better. Ryan Williams from Hawaii Rush says, "I have been on selected for PDT for three years now. I love coming to these events. I have made many friends in the main land."
Rush Competition starts tomorrow. We will keep family, friends and fans posted.
(Pictures: Top right: Parents watch training. 2nd right: Meeting new teammates. Below: Rush Coaches discuss training, U14 Boys train in preparation to defend their 2011 championship.)
Rush Select Final Rosters – Phoenix, AZ - 2012
Below please see the final rosters (2/13/12) for the nine Rush Select Teams traveling to Phoenix for the coming Presidents weekend.
Congratulations and good luck to all players and coaches
G13 Select
Stuart Fitzsimmons (TX)
Dan Highstead (PP)
Kelsey Brann (TX)
Taryn DeLayne Poole (OR)
Kristin Reikersdorfer (WI)
Theresa (Tess) Boade(CO)
Camryn Dyke (CO)
Abi Janszen (TX)
Tayla Wheeler (OR)
Katie Lawrence (TX)
Hailey Sophia Gross (AK)
IzzyDePinto (CO)
Caleigh Michael (CO)
Sofia Weiner (CO)
Molly Ballinger (CO)
Kimberly Rodriguez (TX)
Lacey Adye (OR)
Briana Woodall (TX)
Amanda Porter (CO)
G14 Select
Nik Penn (PP)
Chris Panayiotou (WI)
Amidee Colleknon (OR)
Monica Dallacasa (TX)
Christina Edwards (OR)
Ann-Marie Jaworski (IO)
Catie McDonald (NM)
Gracie Piper (TX)
Meg Brandt (IO)
Jade Pearce (TN)
Cailla Fabro (HI)
Corinne Burns (NY)
Abigail Dolgos (NY)
Nicky Suwa (NY)
Emily Krogman (WI)
Jamie Brunworth (CO)
Sommer Stanley (TX)
Kari Adams (HI)
G15 Select
Matt Mittelstaedt (AR)
Russell Finch (GA)
Alana Dorfstatter (MI)
Emily Marsh (MI)
Karen Lovelace (MI)
Gabbi Mencotti (MI)
Marina Johannesen (OR)
Caroline Buelt (IA)
Natasha Davenport (TN)
Ali Robinson (TX)
Megan Buzzas (OR)
Marin Carter (AR)
Samantha Schoppy (GA)
Teeghan Tvedt (WI)
Maggie Boelman (IA)
Cydney Skinner (PP)
G16 Select
Ben John (WI)
Andrew Kewley (CO)
Brooke Yoshimura (HI)
Rachel Estopare (OR)
Delaney Crook (OR)
Jamie Weiss (CO)
Natalie Ambrose (OR)
Shannon Patterson (OR)
Emily Mouille (WI)
Halle Boyer (IO)
Sarah Brandt (IA)
Liv Miller (CO)
Hadlie Plummer (OR)
Carmen Webster (TX)
Alisha Miyashiro (HI)
Zoe Higgins (OR)
Emily Feltes (IO)
Amanda Ortiz (TN)
B13 Select Machin
Andy Machin (WA)
Mike Piserchio (CO)
Ryan Wilson (CO)
Lars Helleren (WA)
Mikey Alonso (OR)
Sam Alvarez (PP)
Matthew Trautmann (FL)
Dehai Abraham (FL)
Brian Huynh (WA)
Chay Mattos (HI)
Ryan Crowley (CO)
Christopher Jenkins (HI)
Nathan Redd (WA)
Cameron Unk (CO)
Hayden Yezak (TX)
Shandon Hopeau (HI)
Jack O'Brian (CO)
B13 Select Lux
Brian Lux (PP)
Lucas Kim (SOC)
Thomas Martin
Andrew Efaw
Phillip Gustafson
Joe Kempin
Mack Van der Velde
David Solis
Griffin King
Blair Hayden
Cameron Kratt (PP)
Luke Oberto
Sam Sketers
Jacob Suppiah
Hunter Wiebel
Jordan Osborne
Zak Kulphongpatana
Trevor Piel
B14 Select
David Dengerink (TX)
Alex Cardenas (TX)
Nick Cullen (PP)
Payton Miller (TX)
Marcos Lucero (NM)
Jesse Riggs (VA)
Zech Meddleton (NM)
Sergio Rivas (NM)
Michael Swift (TN)
Sean Halverson (PP)
Kiko Macias (NM)
Joe Oritz (NM)
Jeron Cunningham (HI)
Dylan Greco (PP)
Nick Toupin (MI)
Enrico Sanchez (NM)
Ryan Moldenhauser (PP)
Hunter Hayden (TX)
Robert Frusina (TX)
Miguel Lucero (NM)
B15 Select
Nathan Hunt (AK)
Laila Modi (AZ)
Daniel Wilson
Jonathan Finucan (HI)
Owen Lawrence (TX)
Hayden Schmidt (WA)
Santiago Torres (NM)
Doyle Lang (MI)
Phillip Mairov (FL)
Josh Varela (KS)
Ty Belton-Byce (WI)
Johnny Nartowicz (FL)
Chris Holmes (AR)
Ryan Williams (HI)
Ryan Kenyon (PP)
Sean Surtees (WI)
Zachary Ferguson (KS)
Takeo Nystrom (WA)
B16 Select
Eli Ulvi (OR)
Espen Hosien (PP)
Ryan Dickerson (KS)
Alvaro Saldana (HI)
Daniel Rutter (TN)
Alexander Arnis (OR)
Brian Ness (KS)
Chase Clack (TN)
Alex Steen (GA)
Taylor Wiebke (KS)
Jonathon Bentham (FL)
Thomas Guthrie (KS)
Devin Feane (VA)
Juan Luis Solario (GA)
Victor Rivera (GA)
Patrick Rydberg (KS)
Clay Haag (KS)
Kolby Versage (VA)
Presidents Day Tournament Schedule Posted
With only 4 weeks until the nine Select teams travel to AZ, the schedules have been posted.
Click Here for Tournament Schedules.
We have teams in the U13-16 Boys and Girls divisions.
Rush Select add B13 White team to PDT
We are excited to announce the formation of a B13 Select White team to join the existing eight teams traveling to Phoenix, AZ in February 2012.
The team will be coached by Brian Lux (Click Here for Bio) of Rush Pikes Peak (CO) who is very excited to be expanding the pool on the boys side and give more players the opportunity to experience Rush Select.
Rush Soccer President Tim Schulz has also made himself available for the trip to bring the number of Rush Coaches to an astonsishing 25 for the event to be working with the Rush Select Players.
For more information on the tournament please Click Here.
Rush Select Update – Nov 2011
Rush Select is excited to announce the Coaching Staff that will be taking our eight Rush Select Teams to the Presidents Day tournament in Phoenix, AZ., in February 17-21 2012.
We are excited to build on last year's championship and again show the Nation that Rush Soccer is able to put together some of the best teams in the country. Even though the players on the teams spend very little time together, the beauty of soccer and the Rush consistency is that we can still put forth extremely high quality teams with some of the country's best coaching and compete for the Tournament championships.
The player pools are identified and the traveling rosters will be completed before Thanks Giving, so please come back and visit us to see the players that were selected to represent Rush Soccer for February 2012.
Rush Select Coaching Staff
U13 Boys
Andy Machin (WA)
U13 Boys
Mike Piserchio (CO)
U13 Girls
Stuart Fitzsimons (TX)
U13 Girls
Dan Highstead (PP)
U14 Boys
Dave Dengerink (TX)
U14 Boys
Benn Fernie (unaffiliated)
U14 Girls
Nik Penn (PP)
U14 Girls
Chris Panayiotou (WI)
U15 Boys
Nathan Hunt (AK)
U15 Boys
Laila Modi (AZ-PH)
U15 Girls
Matt Mittelstaedt (AR)
U15 Girls
Russell Finch (GA)
U16 Boys
Eli Ulvi(OR)
U16 Boys
Espen Hosoien (PP)
U16 Girls
Corbin Stone (IO)
U16 Girls
Andrew Kewley (CO-NA)
Pictures from the 2010 Presidents Day Tournament


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The Non-Stick Oven Liner keeps your oven cleaner longer! Burned-on spills and splatters will be a thing of the past when you position this reusable, specially coated fiberglass oven liner inside your gas or electric oven. The oven liner catches all those messy drips and because it is non-stick easily wipes clean - without nasty chemicals or endless scrubbing! Keep your oven clean with a non-stick oven liner today. Instructions included. 26" x 18".
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Compaq Computer QVision 1024/I Free Driver Download
Manufactured By:
File Name:
Graphics Card Drivers, Video Drivers, Display
Use DriverGuide's Installer (what's this) Video Tutorial: How to Download & Install a Driver
Device Name
Compaq Computer QVision 1024/I
Supported Operating Systems
Windows 2000
Link to Page
Uploader Notes
Driver for videocard Trident 8900 and 9000 ISA for win 2000 and (maybe) XP
It was tested under Win 2k SP2 on PII233\c512\RAM 128\M\B SY-6KL.
It wasn't tested under XP!
This inf file also contains drivers for other old videodeocards, it is form windows NT 4 RUS,
Executable files taken from win 2k distr.
If You find drivers for other videocards in this inf file, and some files will be missing, than try suplying them from win 2k or win NT4 distr.
Uploaded By
Markian Samborsky (DG Member) on 7/24/2003
Driver Package
Trident9000_w2k.zip (93.3 KB)
Related Drivers
Reviews Summary
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DriverGuide.com - Download Choice
Direct download is available only to our Premium Members. Free members are required to use our DriverGuide installer or consider these Premium options:
DriverGuide.com - Using DriverGuide's Installer
DriverGuide's installer software (Windows only) simplifies the driver installation process. It safely downloads and verifies your driver and then assists in the installation of it.
You may notice that the file size of the installer software is much smaller than the file size of your actual driver. The reason is that first the installer setup file is downloaded, and then the installer software does the work of fetching your driver from our fastest download server.
The installer setup file has been certified safe by leading-class virus and malware scanners.
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Note: Windows only. Mobile, Mac OS and Linux users can choose other download options by deselecting the installer checkbox below the download button.


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Great news, animal advocates! Yesterday U.S. Reps. Tom Marino (R-PA), Jim McGovern (D-MA), John Campbell (R-CA) and Jim Moran (D-VA) reintroduced the Animal Fighting Spectator Prohibition Act, an ASPCA-supported bill to strengthen our federal laws against animal fighting.
While it's already a federal crime to actively participate in an animal fight, it's the spectators who drive the enterprise and make it profitable. This bill would make it a federal offense to attend an organized animal fight and impose additional penalties for bringing a child to a fight.
The Senate passed this bill in the previous Congress, but even with over half the House in support, Congress was unable to pass a final bill. Reintroducing this bill in the early days of the new Congress gives us an opportunity to build on the momentum from the last Congress and help finally close the federal loophole for animal fighting spectators.
Ask your own House representative to support this important humane legislation! Visit the ASPCA Advocacy Center right now to quickly email your U.S. rep in Washington and urge him or her to cosponsor the Animal Fighting Spectator Prohibition Act.


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About LIM College
2011-2012 SGA Elections
Vote for your student officers
Danielle Busken - President
Ms. Danielle Busken is marketing major at LIM College. In December 2010 she received her associate's degree in Fashion Merchandising. Ms. Busken moved to New York in the fall of 2009 from St. Louis, MO. Although miles away from home she finds herself constantly busy. You can find Danielle either around the LIM College campus in Student Life or Admissions. Ms. Busken is a Student Ambassador, Orientation Leader, FYE Mentor, current SGA Vice President and involved in several on-campus activities and events. When you can't find Ms. Busken on the LIM College
campus you will find her at her internship. Ms. Busken currently interns for a small jewelry designer. On the weekends Ms. Busken is out exploring and shopping in the city. After graduating in May 2012, Ms. Busken plans on work for a magazine in their Marketing Department.
As President of the Student Government Association I will continue with our motto: "We are the voice of the students." This past year as Vice President I helped strengthen the relationship between the SGA and the Executive Board, established discounts at local eateries and assisted the Office of Student Financial Services to work on way of communicating with students regarding financing their education and future. My goals for the next year as president is to raise the voice of the students, continue with discounts and strengthen relationships with the different departments at the College. I will work closely with my E-Board and Senate to make sure our goals reflect what the everyday student at LIM College wants. You can rest assured that I will represent your interests and advocate on your behalf.
Kaleigh Connors - Vice President
Ms. Kaleigh Connors is a sophomore here at LIM College,majoring in Visual Merchandising with a concentration in Styling. Ms. Connors has completed internships in the fashion industry and is very involved at the College. Ms. Connors is from New Jersey, but currently is a New Yorker. Ms. Connors says, "New York City is the greatest city in the world and I love living here! I like to think of myself as Carrie Bradshaw from Sex and the City, as I am a huge fan."
Serving as an active member of the Student Government Association over the past academic year as well as belonging to other organizations in the LIM College community, I feel that I have gained the knowledge and understanding to serve as Vice President. LIM College is a great institution and I want to be a part of an organization that is working to make it even better. Since I first became a member of the LIM College Community in August of 2009, I have enjoyed every single day. I believe in LIM College and what it stands for.
As Vice President I will make the SGA more involved with the student body. I think it is important to address the needs and requests of LIM College students. My goal is to make students more involved in the clubs and organizations that have been established here.
I feel that I am highly qualified for this job; I have held several leadership positions over the past few years within LIM College, as well as outside of a school. I am very easy to talk to and am open to any suggestions students have. My personality and dedication will help me succeed if I am elected Vice President.
Alyssa Peseky - Secretary
Ms. Alyssa Peseky is a sophomore here at LIM College and pursuing a Bachelor's degree in Fashion Merchandising. She from Elmira, New York. Ms. Peseky is an Orientation Leader and student mentor. She's a active member of the LIM College community. Ms. Peseky says, "Being a part of LIM College is very important to me in furthering my career. I have participated in as many great internships and looks forward to a successful career in the business of fashion."
Platform: I would like to be secretary of SGA because I feel that I contribute to the success of the team. I am a great note taker and but more importantly I am great listener. It will be an honor to represent you the students on the E-Board.
Victoria Walton - Secretary
Ms. Victoria Walton is a transfer Junior here at LIM College majoring in Fashion Merchandising. Ms. Walton is
an active member of Black Retail Action Group (BRAG) and is the student representative to the SGA.
I am interested in becoming secretary because I would count it as a privilege to represent the students as a chief member of the Student Government Association. As a member during the past semester and having the opportunity to attend the American Student Government Association Conference, I have developed prominent skills necessary to do well at my presented tasks. I believe that a strong student government is a key factor in having a successful student body, and I would graciously like to be a part of both.
Amanda Jaccard - Fashion Merchandising Representative
As a standing junior, I believe I can actively function and operate positively as a Fashion Merchandising Representative in the Student Government Association. I will take this role very seriously and utilize my skills to their fullest potential. One of my biggest strengths is my communication skills. I work very well with all kinds of people and understand that everyone has different perspectives about projects and work tasks. I am a hard worker and dedicate full commitment to my work. As Fashion Merchandising Representative, I promise that I will put my all into every issue and task that is put in front of me.


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Directions for Use: Adults and Children 6 Years and Over: Put 1 or 2 drops in the affected eye(s) up to 4 times every day. Children Under 6 Years: Ask a doctor. Store at 20-25 degrees C (68-77 degrees F). Protect from light.
Other Directions: Do not use if this solution changes color or becomes cloudy; if you are sensitive to any ingredient in this product. Ask a doctor before use if you have heart disease; high blood pressure; trouble urinating; narrow angle glaucoma. When using this product pupils may become enlarged temporarily; overuse may cause redness of the eye(s); remove contact lenses before using; do not touch tip of container to any surface to avoid contamination; replace cap after each use. Stop use and ask a doctor if you feel eye pain; changes in vision occur; redness or irritation of the eye(s) get worse of lasts more than 72 hours. Keep out of the reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Accidental swallowing by infants and children may lead to coma and marked reduction in body temperature. See inside of carton for additional warnings. Tamper Evident: For your protection, the bottle has an imprinted seal around the neck. Do not use if seal is damaged or missing at time of purchase.
Active IngredientsBenzalkonium Chloride, Boric Acid, Edetate Disodium, Purified Water, Sodium Borate, Sodium Chloride, Sodium Hydroxide and/or Hydrochloric Acid.
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The products and claims made about specific products on this site have not been evaluated by Pharmaca.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information on this site is for educational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Pharmaca Integrative Pharmacy will not assume liability for any cross-contamination of ingredients, misprints, or adverse reactions to any ingredients in the products we carry. The products sold here may contain lead and other substances that are known to the state of California to cause cancer and birth defects and other reproductive harm. Prices and promotions are subject to change without notice. All content on this web site is copyrighted by Pharmaca Integrative Pharmacy unless otherwise stated. All online offers and prices are valid for online purchases only, and may be different from those in our retail stores. Free shipping offer may not apply to all orders and all states; see shipping policy for full details. Copyright © 2009 – 2015 by Pharmaca Integrative Pharmacy. All rights reserved.


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Just got home from voting. Took more republicans than I ever have in my entire life.
Just got home from voting. Took more republicans than I ever have in my entire life.
Bill Belichick on "putting the tape on"
I actually think that energy policy is -- or should be -- the real issue in this election. I guess it just doesn't get people excited enough.
Just voted for romney!
Sent from my EVO using Tapatalk 2
Most interesting is the Prop 501 in Washington State. Legalizes pot but institutes a driving while under the influence of weed. Reports are that it will pass. Cancer patients are screwed if the get pulled over.
---------- Post added at 07:02 PM ---------- Previous post was at 07:01 PM ----------
And I'll go ahead and call Hawaii for Obama.
I was at my voting center at 6:30 am today, and there were only 80-100 people ahead of me. Once they stated letting people vote at 7:00 am, I finally cast my ballot at 8:30am. It took an hour and a half for 80-100 people to vote in my precinct, which is one of the largest in Orlando. By the time I had voted an walked out of the building around 8:30am, the line was at least 300-400 people long and many more that were parking miles away were flocking in. I bet many of those people are still in line, and its soooo wrong that my state wont allow more voting locations, and my state also cut the early voting days in half. Its a complete mess in Orlando. I dont expect the Florida results to be certified for quite some time.
Going out on a limb and calling Texas a win for Romney. After all, he promised not to let UN troops invade their state....unlike Obama who secretly plans to.
Terrorist attack count against the Anything Goes Thread: 4
---------- Post added at 01:25 PM ---------- Previous post was at 01:24 PM ----------
Oh... Obama with 294 (Go Virginia!), Tim Kaine, and anyone, ANYONE but Eric Cantor! (Wayne Powell-D)
"We make a living by what we get, but we make a life by what we give."


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Fun, colorful educational art print used to help instill proper etiquette in adolescents. Frame not included. This gently used vintage product is in good condition.
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Inhibitors of USP1/UAF1: SAR in Primary Assay
Deubiquitinating enzymes (DUBs) are a class of enzymes that can cleave isopeptide bond formed between the C-terminal carboxylate of ubiquitin and a lysine side-chain amino group on the target protein. Among them, ubiquitin specific proteases (USPs) constitute the largest DUB family. Human USPs are emerging as promising targets for pharmacological intervention because of their connection to a more ..
BioActive Compounds: 104
Related Experiments
Deubiquitinating enzymes (DUBs) are a class of enzymes that can cleave isopeptide bond formed between the C-terminal carboxylate of ubiquitin and a lysine side-chain amino group on the target protein. Among them, ubiquitin specific proteases (USPs) constitute the largest DUB family. Human USPs are emerging as promising targets for pharmacological intervention because of their connection to a number of human diseases, including prostate, colon and breast cancer (1, 2), pediatric acute lymphoblastic leukemia (3), and familial cylindromatosis (4). The advantage of inhibiting USPs lies in the potential specificity of therapeutic intervention that can lead to better efficacy and reduce nonspecific side effects.
In a collaboration between the University of Delaware and the NIH Chemical Genomics Center, a high-throughput screen assay was developed to screen for USP1/UAF1 inhibitors (5). This assay was used to test the analogs that were synthesized based on SAR around the original hit.
NIH Chemical Genomics Center [NCGC]
NIH Molecular Libraries Probe Centers Network [MLPCN]
MLPCN Grant: DA030552-01
Assay Submitter (PI): Zhihao Zhuang, University of Delaware
1. Priolo, C., et al. (2006) The isopeptidase USP2a protects human prostate cancer from apoptosis. Cancer Res 66, 8625-8632
2. Popov, N., et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 9, 765-774
3. De Pitta, C., et al. (2005) A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. Haematologica 90, 890-898
4. Kovalenko, A., et al. (2003) The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424, 801-805
5. Chen, J., et al. (2011) Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Bio 18(11):1390-400.
3 microliters of reagents (buffer in columns 3 and 4 as negative control and 1nM USP1/UAF1 complex in columns 1, 2, and 5-48) are dispensed into Greiner black solid bottom 1536-well assay plates. Compounds are then transferred via Kalypsys pin tool equipped with 1536-pin array (10nl slotted pins, V&P Scientific, San Diego, CA). Following an incubation step of 15 min at room temperature, 1ul of Ub-Rho substrate (150nM final concentration) is added to initiate the reaction. The plates are immediately centrifuged at 1000 rpm for 15 seconds, and subsequently transferred to a ViewLux high-throughput CCD imager (PerkinElmer) wherein kinetic measurements of fluorescence are acquired using 480 nm excitation/540 nm emission filter set (6 reads every 60 seconds, see Table 1). All reagents are diluted in an assay buffer consisting of 50mM HEPES (pH 7.8), 0.5mM EDTA, 0.1 mg/ml BSA, 1mM TCEP, and 0.01% Tween-20.
Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.
Categorized Comment - additional comments and annotations
From ChEMBL:
Assay Type: Functional
Result Definitions
* Activity Concentration. ** Test Concentration.
Additional Information
Grant Number: DA030552
Data Table (Concise)