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University of Pittsburgh - Heinz Field
This panorama of Heinz Field was taken by James Simmons. It captures the excitement of the opening game kick-off between the University of Pittsburgh Panthers, in their first game as a member of the Atlantic Coast Conference, and the Florida State Seminoles. This nationally televised matchup was the first meeting between the two teams in 30 years. The Panthers have won 3 of the 4 most recent games against Florida State and continue to lead the all-time series 5-4. Florida State was Pitt's highest-ranked season-opening opponent since 1982, when the Panthers hosted No. 5 North Carolina.
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The process of buying a new Honda car or truck can seem overwhelming if you don't know where to begin. Edmunds.com can get you started on the right track with a convenient directory of Honda car dealerships in and around South Hamilton, Massachusetts. Compare online price quotes on the new or used car, truck, SUV, minivan, or wagon of your choice to locate the best deals. Edmunds.com makes it easy to find trusted Honda car dealers in South Hamilton, saving car buyers time and money on what will be an important purchase.
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Soundgarden Confirm Lollapalooza 2010 Headlining Set
It's official! Rumors that freshly-reunited grunge godfathers Soundgarden have booked a live gig in the States meaning a full-on Soundgarden tour -- as have been whispered about since the band first announced it was reuniting back in January -- can't be too far off.
Soundgarden will be one of the headliners of this years Lollapalooz


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A small-town hero discovers his dark side in Jim Mickle's pulpy 'Cold in July'
FILM For film fans, there's a delight that comes from charting a talented director's progress from obscurity to cult fame to "next-big-thing" status. I remember settling in to watch Jim Mickle's 2010 breakout Stake Land (his first feature was 2006's micro-budget creature feature Mulberry Street, which played multiple festivals on the genre circuit). I knew it was a vampire movie, a weary subject thanks to Twilight mania, but it soon became clear that Stake Land was not a by-the-numbers affair: Within the first five minutes, a crusty fang-slinger devours a human infant. "This is not a film to be fucked with," I scribbled in my review, and filed away the name "Jim Mickle" for future consideration.
Last year, he returned with We Are What We Are, a remake of a Mexican chiller about cannibals fighting to keep their secret traditions alive despite pesky interference from the modern world. It was his third film with writing partner Nick Damici — also the lead in Mickle's first two films, though he moved to a supporting role in We Are, which focused mostly on the teen sisters at its core. Set in rural upstate New York, We Are had its share of gore, but it also went deeper, teasing out a macabre and surprisingly detailed history of its flesh-eating family.
"To me, it's more of a dark story about faith and religion," he told me in an interview at the time. "I was much more interested in the girls' story, and the story of a family trying to hold together after a tragic event."
Now comes Mickle's most accomplished film to date, and it's even less overtly horror (though it contains a multitude of terrifying moments): Cold in July, a thriller ranging across East Texas, circa 1989. The script by Team Mickle-Damici is adapted from the novel by Joe R. Lansdale, who — buckle up, cultists — also penned the short story which spawned 2002's Bubba Ho-Tep. That said, there are no supernatural elements afoot here; all darkness springs entirely from the coal-black hearts beating in its characters.
Well, some of its characters. Cold in July begins with a killing, but the trigger hand is attached to mild-mannered frame-store owner Richard Dane (Dexter's Michael C. Hall, rocking a splendid mullet). The masked man he shot was breaking into the Dane family home; Richard was just protecting his wife (Vinessa Shaw) and young son (Brogan Hall). That he accidentally, kinda, nailed the burglar — spraying brains everywhere, necessitating amusing later scenes of weary clean-up and furniture replacement — is breezed over by the police (including a cowboy-hatted Damici). "Sometimes, the good guy wins," they assure him.
The good guy/bad guy dynamic is twisted, tested, and taken to extremes as Cold in July continues; it's the sort of film best viewed without much knowledge of its plot twists, which are numerous and cleverly plotted. (Which is to say: You may read on, genre junkie, without fear of spoilers, because I don't wanna ruin anyone's viewing enjoyment.) The day after his run-in with vigilante justice, Richard realizes he's the number one conversation topic in his small town, and his shiny local-hero status has attracted the attention of the dead robber's father (Sam Shepard), just out of the clink and skilled in the art of Cape Fear-style menace.
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- Overview
- President's Letter
- Rankings & Accolades
- Environmental Commitment
- Facilities and Research
- News and Events
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About COA
College of the Atlantic is a small, liberal arts college on Mount Desert Island, off the coast of Maine. Founded in 1969, COA offers all students a shared focus: human ecology. How that focus is directed is up to each student. Whether observing whales from the college's research vessel, pursuing an independent photo-journalism project in the Yucatan, studying international treaties, converting a campus building to solar power, or volunteering on one of COA's organic farms, students at COA learn from experience both inside and outside the classroom.
At COA each student designs his or her own course of study in human ecology. Faculty at the College are passionate about teaching and relish interacting with their students, which allows students to pursue their interests with academic guidance and enthusiasm. With an advisor, students are encouraged to chart their educational journeys based on their individual goals and passions.
Academics here are rigorous, with an approach to learning where students not only think, read, and write, but also create, act, and do. Studies here bring together perspectives from multiple disciplines to address issues facing our world. Academic pursuits will lead from classroom, studio, and laboratory to field, island, and community. COA students push themselves, expand their thinking, and explore new paradigms.
The Atlantic Ocean is our front yard, and Acadia National Park is in our back yard. An inspiring and close-knit community, there is room at COA both for lively academic discussions and solitary contemplation. There are also opportunities to expand beyond the campus: more than half of COA students include international study in their curriculum, and 100% of our students complete an internship while they work toward their degree.
Students and faculty come to COA because they long to enhance the good in the world while discovering new ways to transmute the difficulties. If you like the idea of small, rigorous classes, ocean air, and an inspiring academic community, we encourage you to sign up for more information about COA.
The Parent Perspective
COA Video for Prospective Parents from College of the Atlantic on Vimeo.
Career Possibilities
COA students go on to careers in many fields. But at the end of the day, what sets them apart is that they care — and often find creative ways to express this caring.
Here are just a handful of examples:
- Urs Riggenbach '12 Solar Fire Energy, designed local, renewable energy system for remote Nepalese school
- Elena Piekut '09, Assistant City Planner at City of Ellsworth, Maine
- Juan Hoffmaister '07, Loss & Damage Coordinator for the United Nation's G-77, China
- Scott Bishop '97 National Design Award-winning landscape designer
- Amy Toensing '93 National Geographic photographer
- Nell Newman '87, CEO, Newman's Own Organics
- Chellie Pingree '79, US Congresswoman from Maine
- Scott Kraus '77, VP for Research, New England Aquarium


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Photos: [top] Jack and [bottom] Jill, before and after receiving treatment at the ASPCA Animal Hospital.
Can you imagine leaving your pets behind in your former home, even in the worst possible circumstances? We can't either. And yet, after Jerome Smith, 23, was evicted from his Harlem apartment, he chose to do just that to his six-month-old puppies.
When New York City Animal Care & Control officers opened the door to Smith's former home in September, they found Terrier mix puppies Jack and Jill, all alone and in bad shape.
The officers called ASPCA Humane Law Enforcement, and our agents brought the pups to the ASPCA Animal Hospital right away.
ASPCA veterinarians found Jack and Jill to be dehydrated, malnourished and severely underweight. Jack weighed 12.7 pounds and Jill weighed 8.5 pounds. By contrast, after being fed a balanced diet and receiving treatment by ASPCA staff, Jack now weighs 36.5 pounds and Jill weighs 30.3 pounds—a 187 and 256 percent increase, respectively.
The ASPCA arrested Smith in December. He was charged with two counts of misdemeanor animal cruelty. If convicted, he faces up to two years in jail and/or a $2,000 fine.
Jack and Jill's story ends happily. On January 13, Jill was adopted! Jack is waiting for a forever family at the ASPCA Adoption Center, located in Manhattan. To learn more about how you can adopt Jack, please visit the ASPCA Adoption Center online.
Update 1/18/13: We are thrilled to report that Jack was adopted!
If you suspect you've witnessed animal cruelty, please report it.


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Browse and search white papers and mission & technology studies received by the Planetary Science Decadal Survey. Click here for basic user instructions.
Title: Jupiter Atmospheric Science in the Next Decade
Primary Author: Leigh N. Fletcher
Secondary Author(s): G. Orton, T. Stallard, K. Baines, K. M. Sayanagi, F. J. Martin-Torres, M. Hofstadter, I. de Pater, S. Edgington, R. Morales-Juberias, T. Livengood, D. Huestis, P.
Hartogh, D.H. Atkinson, J. Moses, M. Wong, U. Dyudina, A.J. Friedson, T.R. Spilker, R.T. Pappalardo, P.G.J. Irwin, N. Teanby, T. Cavalié, O. Mousis, A.P. Showman, X. Liu, M.B. Lystrup, S. Gulkis, T. Greathouse, R. K. Achterberg, G.L. Bjoraker, S.S. Limaye, P. Read, D. Gautier, D.S. Choi, T. Kostiuk, A.F. Nagy, D. Huestis, M.
Choukroun, I. Muller-Wodarg, P. Yanamandra-Fisher
Institution: Jet Propulsion Laboratory
Summary: We outline atmospheric science goals and requirements for Jupiter in the next decade exploration (Juno, EJSM, Observatories, probes) in 5 themes: formation and evolution, weather-layer dynamics, coupling with the interior, interactions with the external environment and time-variable phenomena.
Panel Selection: Giant Planets: Jupiter, Saturn, Uranus, Neptune, and exoplanets, including rings and magnetic fields, but not their satellites.
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Return to Index
These documents have been prepared in coordination with the National Academies of Science in support of the National Academies Planetary Science Decadal Survey. These documents are being made available for information purposes only, and any views and opinions expressed herein do not necessarily state or reflect those of NASA, JPL, or the California Institute of Technology.


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90 softgels, Item# 00993
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was $44.00
$17.60 each
was $33.00
$17.60 each
Canadian scientists have reported that a decrease in energy expenditure with aging may cause 120–190 excess calories to be stored in the body every day,74 which translates to an extra 13–20 pounds of body fat a year! To achieve optimal results as we age, we must restore the ability of our cells to maintain a youthful metabolic rate.
Thermogenesis is the process of producing cellular energy in the form of heat, which can be triggered by a factor called mitochondrial uncoupling protein-1. Japanese scientists discovered that a plant extract called fucoxanthin activates uncoupling protein-1 that signals fatty acids to generate energy rather than remain stored as body fat.75
Derived from a specie of Japanese brown seaweed, fucoxanthin provides a unique solution for safely boosting cellular metabolism.
Unlike many "fat burners" that stimulate the central nervous system to promote weight loss, fucoxanthin works directly in fat cells.75,76 By targeting energy distribution at the mitochondrial level, this non-stimulatory action provides aging humans with an important new mechanism of action to achieve successful long-term weight management.
Scientists have found that the weight loss benefits of fucoxanthin are enhanced by combining it with pomegranate seed oil. The active ingredient in pomegranate oil (punicic acid) reduces blood supply to fat cells and precludes them from increasing in size.77-79
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
|Supplement Facts
Xanthigen® is a registered trademark of Polifenoles Naturales. U.S. Patent No. 8,367,072.
|Dosage and Use


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Hartmann Reserve Zip Travel Organizer
The Belting Leather Collection represents the pinnacle of refined style and superior quality.
Made from ultra durable Belting Leather for beauty and years of use. The Zip travel Organizer features on the left side, a large pocket for itinerary to tickets, small slash pocket for passport and a credit card pocket. The right side has a pull-out currency sleeve with snap closure, 8 pockets for credit or business cards and an ID window. Zip closure for security and a slash pocket on the back for easy access.
Lifetime warranty.
Dimensions: 1" L x 5" W x 10" H; 0.5 lb.
Hartmann Reserve Zip Travel Organizer
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Our innovative products will provide you and your family with years of enjoyment. And with the Brookstone Protection Plus service and replacement plans, you'll have the added peace of mind knowing that if the unexpected does happen, we will simply repair or replace your covered product. Our enhanced coverage goes above and beyond the manufacturer's warranty, saving you time and money.
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Hartmann Reserve Zip Travel Organizer
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Kamui Kobayashi was confident of a great result at Suzuka as long as he got off to a good start - he did and he finished on the podium...
Kamui Kobayashi was confident of a great result at Suzuka as long as he got off to a good start - he did and he finished on the podium.
The Sauber driver, who has yet to secure his Formula One future, started Sunday's Japanese GP from third on the grid and quickly made his way up to second.
He lost that position to Felipe Massa in the first round of pit stops before coming under pressure from behind from Jenson Button.
However, the 26-year-old kept the McLaren at bay to claim his maiden F1 podium and did so on home soil.
"It was a fantastic race," said Kobayashi.
"We were really working hard to get a podium and my team-mate has a couple of podiums already.
"I had a couple of chances in qualifying with good grid positions - but I never had luck.
"I've struggled on starts - many starts - but this time I think it was good to start in third.
"It was not a front row but the feeling was good because we had a long run on Friday and that was pretty good pace.
"I was confident through the weekend so when I gained position after the start I was pretty sure I could be on the podium.
"Then at some point we struggled a lot to hold Jenson off. The last stint was very tough."
Kobayashi was greeted on the podium with rousing applause from the Japanese fans who chanted his name as they celebrated with him.
"I think finally finishing in points is fantastic, especially in front of my home grand prix," the Sauber driver added.
"This is my first podium and it's amazing. I am happy for the fans and so many people supporting me.
"When you look around circuit, it is amazing. So thank you to the fans and we need to keep going for the future."
As for his future in Formula One, the Japanese driver admitted he is under pressure.
"Yes of course, sometimes I feel pressure but maybe I need to enjoy more."
Related Links
Vettel Wins In Japan While Alonso Retires
The Japanese GP In Pictures


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The Assos SS.neoPro jersey is designed to follow the contours of your body for a non-restrictive, comfortable fit, even in the tuck position. Raglan cut shoulders are tailored with a soft, supple material for greater freedom of movement, while the longer sleeves and slightly higher collar give the jersey a distinctive look. Lightweight Type.197 fabric, used throughout the jersey body, protects you from over-heating by regulating, maintaining and stabilizing your personal microclimate and is made out of 100% recycled p.e.t. bottles. This textile is another step towards Assos target of "zero impact" manufacturing. Full-length zipper and three rear pockets.
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August 20, 2012 6:55 am Leneha Junsu
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|Publication number
|Publication type
|Application number
|Publication date
|Nov 16, 2006
|Filing date
|Jul 20, 2006
|Priority date
|Nov 12, 2004
|Also published as
|Publication number
|Allen Wyler, Brad Fowler
|Original Assignee
|Northstar Neuroscience, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Referenced by (6), Classifications (6), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention is directed generally toward systems and methods for selecting stimulation sites and treating symptoms of Parkinson's disease and other movement disorders, and/or drug side effects, for example, via electrical stimulation at the selected sites.
A wide variety of mental and physical processes are controlled or influenced by neural activity in particular regions of the brain. For example, various physical or cognitive functions are directed or affected by neural activity within the sensory or motor cortices. Across most individuals, particular areas of the brain appear to have distinct functions. In the majority of people, for example, the areas of the occipital lobes relate to vision; the regions of the left interior frontal lobes relate to language; portions of the cerebral cortex appear to be consistently involved with conscious awareness, memory, and intellect; and particular regions of the cerebral cortex, the basal ganglia, the thalamus, and the motor cortex cooperatively interact to facilitate motor function control.
Many problems or abnormalities with body functions can be caused by damage, disease, and/or disorders in the brain. For example, Parkinson's Disease (PD) is related to the degeneration or death of dopamine producing neurons in the substantia nigra region of the basal ganglia in the brain. Dopamine is a neurotransmitter that transmits signals between areas of the brain. As the neurons in the substantia nigra deteriorate, the reduction in dopamine causes abnormal neural activity that results in a chronic, progressive deterioration of motor function control. Conservative estimates indicate that PD may affect more than one million individuals in the United States alone.
PD patients typically exhibit one or more of four primary symptoms. One primary symptom is a tremor in an extremity (e.g., a hand) that occurs while the extremity is at rest. Other primary symptoms include a generalized slowness of movement (bradykinesia); increased muscle rigidity or stiffness (rigidity); and gait or balance problems (postural dysfunction). In addition to or in lieu of these primary symptoms, PD patients may exhibit secondary symptoms including: difficulty initiating or resuming movements; loss of fine motor skills; lack of arm swing on the affected side of the body while walking; foot drag on the affected side of the body; decreased facial expression; voice and/or speech changes; cognitive disorders; feelings of depression or anxiety; and/or other symptoms.
Effectively treating PD or other movement disorders related to neurological conditions can be very difficult. Current treatments for PD symptoms include drugs, ablative surgical intervention, and/or neural stimulation. Drug treatments or therapies may involve, for example, the administration of a dopamine precursor that is converted to dopamine within the central nervous system (i.e., Levodopa (L-dopa)). Other types of drug therapies are also available. Unfortunately, drug therapies frequently become less effective or ineffective over time for an undesirably large patient population. A PD patient may require multiple drugs in combination to extend the time period of efficacy of drug therapies. Drug treatments additionally have a significant likelihood of inducing undesirable physical side effects; motor function complications such as uncontrollable involuntary movements (dyskinesias) are a particularly common side effect. Furthermore, drug treatments may induce undesirable cognitive side effects such as confusion and/or hallucinations.
Ablative surgical intervention for PD typically involves the destruction of one or more neural structures within the basal ganglia or thalamus that have become overactive because of the lack of dopamine. Unfortunately, such neural structures reside deep within the brain, and hence ablative surgical intervention is a very time consuming and highly invasive procedure. Potential complications associated with the procedure include risk of hemorrhage, stroke, and/or paralysis. Moreover, because PD is a progressive disease, multiple deep brain surgeries may be required as symptoms progressively worsen over time. Although ablative surgical intervention may improve a PD patient's motor function, it is not likely to completely restore normal motor function. Furthermore, since ablative surgical intervention permanently destroys neural tissue, the effects of such intervention cannot be readily adjusted or "fine tuned" over time.
Neural stimulation treatments have shown promising results for reducing some of the symptoms associated with PD. Neural activity is governed by electrical impulses or "action potentials" generated in and propagated by neurons. While in a quiescent state, a neuron is negatively polarized and exhibits a resting membrane potential that is typically between −70 and −60 mV. Through chemical connections known as synapses, any given neuron receives excitatory and inhibitory input signals or stimuli from other neurons. A neuron integrates the excitatory and inhibitory input signals it receives, and generates or fires a series of action potentials in the event that the integration exceeds a threshold potential. A neural firing threshold, for example, may be approximately −55 mV. Action potentials propagate to the neuron's synapses and are then conveyed to other synaptically connected neurons.
Neural activity in the brain can be influenced by neural stimulation, which involves the application of electrical and/or magnetic stimuli to one or more target neural populations within a patient using a waveform generator or other type of device. Various neural functions can thus be promoted or disrupted by applying an electrical current to one or more regions of the brain. As a result, researchers have attempted to treat certain neurological conditions, including PD, using electrical or magnetic stimulation signals to control or affect brain functions.
Deep Brain Stimulation (DBS) is a stimulation therapy that has been used as an alternative to drug treatments and ablative surgical therapies. In DBS, one or more electrodes are surgically implanted into the brain proximate to deep brain or subcortical neural structures. For treating PD or other movement disorders, the electrodes are positioned in or proximate to the ventrointermediate nucleus of the thalamus; basal ganglia structures such as the globus pallidus internalis (GPi); or the Subthalamic Nucleus (STN). The location of the stimulation site for the electrodes depends upon the symptoms that a patient exhibits and the severity of the symptoms.
In a typical DBS system, a pulse generator delivers a continuous or essentially continuous electrical stimulation signal having a pulse repetition frequency of approximately 100 Hz to each of two deep brain electrodes. The electrodes are may be positioned bilaterally on the left and right sides of the brain relative to particular neural structures such as those indicated above. U.S. Pat. No. 5,883,709 discloses one conventional DBS system for treating movement disorders.
Although DBS therapies may significantly reduce one or more PD symptoms, particularly when combined with drug treatments, they are highly invasive procedures. In general, configuring a DBS system to properly function within a patient requires two time consuming, highly invasive surgical procedures for implanting the DBS electrodes. Each such surgical procedure has essentially the same risks as those described above for ablative surgical intervention. Moreover, DBS may not provide relief from some movement disorders.
Motor Cortex Stimulation (MCS) is another type of brain stimulation treatment that has been proposed for treating Parkinson's Disease. MCS involves the application of stimulation signals to the motor cortex of a patient. One MCS system includes a pulse generator connected to a strip electrode that is surgically implanted over a portion of only the motor cortex (precentral gyrus). The use of MCS to treat PD symptoms is described in Canavero, Sergio, Extradural Motor Cortex Stimulation for Advanced Parkinson's Disease: Case Report, Movement Disorders (Vol. 15, No. 1, 2000).
Because MCS involves the application of stimulation signals to surface regions of the brain rather than deep neural structures, electrode implantation procedures for MCS are significantly less invasive and time consuming than those for DBS. As a result, MCS may be a safer and simpler alternative to DBS for treating PD symptoms. Present MCS techniques, however, fail to address or adequately consider a variety of factors that may enhance or optimize the extent to which a patient experiences short term and/or long term relief from PD symptoms.
The following disclosure describes several embodiments of methods and systems for treating movement disorders (e.g., Parkinson's Disease (PD)) and/or associated symptoms, and/or symptoms associated with drug side effects, using cortical stimulation. Several methods and systems for applying treatment in accordance with embodiments of the invention are set forth and described in
A method for treating movement disorders in accordance with one embodiment of the invention includes determining that the movement disorder affects a patient's gait, and applying electrical stimulation to a region of the patient's brain that is proximate to the interhemispheric fissure of the patient's brain. In another embodiment, the method can include determining that the movement disorder affects the patient's oral functioning, and can further include applying electrical stimulation to a region of the patient's brain that is proximate to the Sylvian fissure of the patient's brain. In still another embodiment, the method can include determining that the movement disorder affects an aspect of the patient's movement other than the patient's gait and oral functioning, and can further include applying electrical stimulation to a region of the patient's brain that is located between the interhemispheric fissure and the Sylvian fissure of the patient's brain.
Methods in accordance with further aspects of the invention can further include applying electrical stimulation to both sides of the central sulcus of the patient's brain, or on a single side of the central sulcus of the patient's brain. Stimulation can be applied ipsilaterally or contralaterally, in a unipolar manner, and/or in a bipolar manner.
In a still a further aspect of the invention, a method for treating movement disorders includes selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient. The method can further include applying electrical stimulation to a location of the patient's brain associated with the at least one neural process. For example, the method can include selecting the at least one neural process from among a planning process, an initiation process, and an execution process. The method can further include applying electrical stimulation to the patient's dorsolateral prefrontal cortex, interhemispheric fissure, primary motor strip, or premotor cortex of the patient's brain.
In yet another embodiment, electrical stimulation can be used to address aspects of a patient's functioning that are attributed to drug intake (e.g., drug side effects). A method in accordance with one such embodiment includes determining what aspect of a patient's functioning is affected by the patient's drug intake, and applying electrical stimulation to a region of the brain that is associated with the aspect of the patient's functioning. In particular embodiments, this method can be used to address cognitive and/or motor dysfunctions resulting as side effects from the patient's intake of drugs that target Parkinson's disease and/or other movement disorders.
In process portion 104, the method 100 includes applying electrical stimulation to a region of the patient's brain that is associated with the particular aspect of the patient's motion identified in process portion 102. In particular, different parts of the brain may be associated with different aspects of the patient's movements, and the method 100 can include stimulating or preferentially stimulating those areas most closely associated with the particular symptoms experienced by the patient. Further details of the brain areas that can be stimulated in accordance with embodiments of the invention are described below with reference to
Referring now to
In other embodiments, methods similar in part to those described above with reference to
In further particular examples, the drug or drugs taken by the patient can include drugs taken to address movement disorders (e.g., PD) but that have side effects on the patient's cognitive and/or motor functioning. L-dopa is one such drug that can induce unwanted dyskinesias (e.g., chorea and/or dystonia). The dyskinesias can include peak-doses dyskinesias (associated with peak levels of L-dopa in the brain), "off" dyskinesias (which occurs when the effects of L-dopa wear off), and/or diphasic dyskinesias (associated with changes in the plasma level of L-dopa, typically at the beginning and/or end of a dose). Other drugs or chemical substances that may produce unwanted side effects can include Sinemet, Mirapex and glial-derived neurotrophic factor (GDNF).
The site(s) of the patient's brain selected for stimulation can depend on the aspects of the patient's functioning to be addressed. For example, if the effects of the drug are related to the patient's motion, the stimulation can be applied to the primary motor cortex, premotor cortex and/or supplemental motor area. If the effects relate to the patient's cognitive abilities, the stimulation can be applied to the prefrontal cortex. Illustrations of representative stimulation systems and stimulation sites associated with the foregoing method are described below with reference to
The electrode device 231 may include one or more electrically conductive contacts 232 carried by one or more substrates 236, for example, in a manner described in U.S. application Ser. No. 10/742,579, entitled "Methods and Apparatus for Applying Electrical Stimulation and Manufacturing Same," filed on Dec. 18, 2003, and incorporated herein by reference. The contacts 232 are configured to provide, deliver, and/or apply stimulation signals to particular cortical regions of the patient's brain 210 and/or neural populations synaptically connected and/or proximate thereto. The electrode device 231 may alternatively or additionally include one or more penetrating, depth, deep brain, and/or nerve cuff electrodes. One or more of the contacts 232 may be configured as a signal return contact (i.e., a contact that provides a current return path for electrical continuity), and may be positioned relative to a variety of locations within and/or upon the patient's body to facilitate unipolar stimulation. This function may also be provided by other structures (e.g., a housing or other portion of the electrode device 231). In another embodiment, one or more of the contacts 232 can be configured to provide bipolar signals (e.g., the return contact can be positioned at or proximate to the stimulation site).
The characteristics and/or placement of the electrode device 231 may depend upon the nature of patient's underlying disorder(s), functional deficit(s), and/or the type and/or severity of symptoms that the patient 200 experiences or exhibits. In a particular embodiment, one or more portions of the electrode device 231 may be surgically implanted to apply, deliver, and/or direct stimulation signals to target neural populations within the patient's brain, for example, in a manner identical, essentially identical, or analogous to that described in U.S. application Ser. No. 10/732,731, entitled "System and Method for Treating Parkinson's Disease and Other Movement Disorders," filed on Dec. 9, 2003, and/or U.S. application Ser. No. 09/802,808, filed on Mar. 8, 2001, both incorporated herein by reference.
The electrode device 231 receives stimulation signals from the pulse generator 235, which may include hardware and/or software for generating and outputting stimulation signals in accordance with internal instruction sequences and/or in response to control signals, commands, instructions, and/or other information received from the controller(s) 240. The pulse generator 235 may include a power supply and a pulse unit, a programmable computer medium, and a communication unit. The power supply may include a battery or other type of power storage device. The pulse unit may include circuitry for generating pulse sequences that may be defined or characterized in accordance with various stimulation signal parameters. Stimulation can be provided at a current of from between 2 and 20 milliamps and at a frequency of 0.5 Hz, 1-2 Hz, or higher. In some embodiments, a generally low frequency signal (e.g., from about 0.5-10 Hz) can result in longer lasting beneficial effects and/or greater relief from adverse symptoms. In some embodiments, it is also beneficial to have a "reset" period. For example, the patient can undergo stimulation for a period of seconds, minutes, hours or days, followed by a period of no stimulation (e.g., for a number of seconds, minutes or hours) before stimulation begins again.
In a particular embodiment, the frequency of the stimulation signal can be varied in a random, aperiodic manner centered, for example, at a mean frequency of 5 Hz. The voltage or amplitude of the signal can be constant or can be varied in a variety of manners, including random variation and/or occasional high amplitude bursts. The range of frequencies may focus on the lower frequency ranges (e.g., from 1-2 Hz) and, for biphasic pulses, the first phase pulse width can be varied. In particular embodiments, the frequency can be varied in a manner indicated to break up oscillatory patterns that may exist between cortical and subcortical structures. Such signal patterns have been associated with Parkinson's disease and may be associated with other movement disorders as well. Aspects of these patterns are described by Timmermann et al. in an article titled, "The Cerebral Oscillatory Network of Parkinsonian Resting Tremor" (Brain (2003), 126, 199-212), incorporated herein in its entirety by reference. Further aspects of applicable signal parameters are described in co-pending U.S. application Ser. No. 10/782,526, filed Feb. 19, 2004 and incorporated herein in its entirety by reference.
Each element of the pulse generator 235 may be incorporated or embedded in a surgically implantable case or housing. Depending upon embodiment details, the pulse generator 235 may be surgically implanted in the patient 200 at a subclavicular location 202. Alternatively, the pulse generator 235 may be surgically implanted above the patient's neck, for example, in the patient's skull at a location posterior to the patient's ear and/or proximate to an electrode implantation site. A surgically formed tunnel or path may route the lead or leads 233 that couple the pulse generator 235 to the electrode device 231, in a manner understood by those skilled in the art. Additionally, one or more electrically conductive portions of the pulse generator case or housing may serve as a return electrode for electrical current.
The controllers 240 may comprise hardware and/or software configured to direct and/or manage the local operation of the pulse generator 235. For example, the controllers may be configured to communicate control signals, commands, instructions, parameter settings and/or ranges, and/or other information to the pulse generator 235. Accordingly, the controllers 240 may each include a processing unit 241, a programmable or other computer-readable medium 242, and a communications unit 243. The communications unit 243 may include a user interface that facilitates communication with devices external to the pulse generator 235, for example, through telemetric signal transfer. The computer-readable medium 242 may comprise hardware and/or memory resident software. The computer-readable medium 242 may store operational mode information and/or program instruction sequences that may be selected and/or specified by a practitioner. The pulse generator 235 may be configured to deliver stimulation signals to particular electrode devices 231 and/or to specific electrical contacts 232 of the electrode device 231 on a selective basis at any given time, e.g., in a manner identical, essentially identical, or analogous to that described in U.S. application Ser. No. 09/978,134, entitled "Systems and Methods for Automatically Optimizing Stimulation Parameters and Electrode Configurations for Neuro-Stimulators," filed on Oct. 15, 2001, and incorporated herein by reference.
The first controller 240 a can include a "full functionality" controller, configured for operation by a medical professional. The second controller 240 b can include a limited or "partial functionality" controller configured for operation by a patient. The second controller 240 b may facilitate patient-based selection and/or adjustment of particular preprogrammed operating modes and/or neural stimulation settings. In some embodiments, the first and second controllers 240 a, 240 b may be configured for wire-based or wireless communication with each other. One or both of the controllers 240 may be configured to receive information from the pulse generator 235 (e.g., the overall status and/or performance level of the pulse generator 235). Communication between the control system 234 and the pulse generator 235 may facilitate or effectuate specification, selection, and/or identification of operational modes, instruction sequences, and/or procedures for treating one or more patient conditions, states, and/or symptoms associated with PD, other movement disorders, and/or other types of neurologic dysfunction in a variety of manners.
The patient monitoring unit 250 may be used to determine the effects of the stimulation signals provided by the controller(s) 240, the pulse generator 235, and the electrode device(s) 231. Accordingly, the patient monitoring unit can include any type of device configured to detect, monitor, indicate, estimate, characterize, measure, calculate, and/or assess neural pathway characteristics and/or the nature, level, intensity, magnitude and/or severity of one or more types of patient states, conditions, deficits, and/or symptoms associated with PD and/or other neurological dysfunctions. For example, a patient monitoring unit 250 may include a motion detection system configured to detect patient movement associated with tremor. A motion detection system may include light emitting and/or detecting devices and/or accelerometers coupled to particular patient extremities. In another example, the patient monitoring unit 250 includes an Electromyography (EMG) system that has one or more sets of surface or depth electrodes positioned relative to particular muscle groups for detecting electrical signals corresponding to muscle fiber innervation. In still another example, the patient monitoring unit 250 includes an Electroencephalography (EEG), an Electrocorticography (ECoG) system, and/or a Magnetoencephalography (MEG) system. In yet another embodiment, the patient monitoring unit 250 includes one or more electrode contacts 232 and, optionally, software and/or hardware (e.g., signal processing software and/or circuitry) within the pulse generator 235.
In other arrangements, the patient monitoring unit 250 includes a neural imaging system, for example, a Magnetic Resonance Imaging (MRI), a functional MRI (fMRI), a Positron Emission Tomography (PET), and/or other type of system. As another example, the patient monitoring unit 250 may include one or more electrodes and/or probes (e.g., cerebral bloodflow monitors) positioned upon, proximate, and/or within given target neural populations, and associated hardware and/or software for detecting, presenting, and/or analyzing signals received therefrom. Still further examples of patient monitoring units are described in co-pending U.S. application Ser. No. 10/782,526, previously incorporated herein by reference.
In addition to illustrating a representative stimulation system 230,
The electrode device 231 can include a plurality of contacts 232 that provide stimulation at one or more stimulation sites 218. Accordingly, the practitioner can sequentially stimulate at a different site (a) when it is not clearly evident, except by trial, where stimulation is most effective, and/or (b) when the patient 200 benefits from stimulation at multiple sites. In the latter case, stimulation may also be applied simultaneously to multiple sites.
In one aspect of this embodiment, the contacts 232 can be arranged in a 2�3 array, and in other embodiments, the contacts 232 can be arranged in arrays having other dimensions, including a single row of contacts 232. Each contact 232 can have a surface area and spacing selected to provide stimulation in the desired fashion. For example, in one embodiment, the contacts 232 have a surface area of about 5 mm2, and each contact 232 can be spaced apart from its nearest neighbor by about 2.5 mm. In other embodiments, the size of the contacts 232 and the spacing between the contacts 232 can be different.
In any of the foregoing embodiments, the electrical stimulation provided by the electrode device 231 can reduce and/or eliminate gait-related symptoms experienced by the patient 200. The electrical stimulation provided by the electrode device 231 can be selected by the practitioner to provide unipolar and/or bipolar stimulation. As used herein, unipolar stimulation refers generally to stimulation provided by one or more contacts proximate to a given stimulation site 218 while all the contacts 232 are at or near the same electrical potential. In this case, a return electrode or contact is provided at a site distal the stimulation site 218, for example, at the implanted pulse generator 235. Conversely, bipolar stimulation, as used herein, refers generally to stimulation provided by at least two contacts 232 positioned proximate to the stimulation site 218, with one of the contacts at a higher electrical potential than the other. Multiple contacts 232 can be arranged in bipolar pairs, with each pair including one contact 232 at a higher potential than its pair mate. The pulse control system 234 can be configured to provide both unipolar and bipolar stimulation signals to the electrode device 231. Accordingly, the same electrode device 231 and pulse control system 234 can be used for patients receiving bipolar and unipolar stimulation. Furthermore, the pulse control system 234 can be programmed or reprogrammed during treatment to switch between bipolar and unipolar stimulation, when this type of alternation provides or is expected to provide an additional benefit to the patient.
In still further embodiments, aspects of the arrangements described above with reference to
In block 504, electrical stimulation is applied to a location of the patient's brain associated with the at least one neural process selected in block 502. For example, in many cases, a different specific area of the brain is associated with each of the planning, initiation, and execution processes. Accordingly, the electrical stimulation can be applied to the location of the patient's brain associated with one or more of the foregoing processes.
Once the (at least one) target neural process has been selected, the practitioner can implant an electrode device at least proximate to the area of the patient's brain associated with the target neural process.
A stimulation system 630 for stimulating the brain 210 can include a pulse generator 635 coupled to one or more pulse control systems (not shown in
Stimulation signals may be provided to the brain 210 in accordance with any of the parameters described above with reference to
In some patients, a defect associated with one of the foregoing sequential processes may predominate. Once the defect associated with this process has been addressed, defects associated with other processes may become more evident. In other cases, it may be impossible or impracticable to identify which process is primarily responsible for the patient's symptoms, for example, because the processes are typically executed by the patient in very rapid succession. In any of these cases, the practitioner may implant multiple electrode devices and/or multiple contacts covering a range of target regions of the brain, and then stimulate a particular region until the problem with that region is addressed (or eliminated as a source of symptoms), then move to another region if symptoms associated with that region become evident, or if stimulation at the first region does not have the desired effect. Stimulation can be provided at multiple sites in a sequential, simultaneous, alternating, random, pseudorandom, and/or intermittent manner. The multiple electrode devices can be implanted simultaneously or serially (e.g., after stimulation with an initial electrode device has been completed or determined to be ineffective).
As described above with reference to
In other embodiments, the systems described above can be implanted and operated in still further manners. For example, one or more electrode devices can be implanted in a manner that places first and second electrical contacts proximate to different areas of the patients brain. Electrical stimulation can then be applied simultaneously or sequentially to these areas to treat one or more neural dysfunctions, and the implantation site can be selected in a manner that does not necessarily require identifying the functional manifestation of the neural dysfunction. In a particular embodiment, the stimulation can be applied to any two (or more) of the motor cortex, the prefrontal cortex and the supplementary motor area. As used herein, the term motor cortex can include the primary motor cortex and/or the premotor cortex. The stimulation can be applied to one or both of the patient's brain hemispheres. In other embodiments, the stimulation can be applied to other multiple locations.
From the foregoing, it will be appreciated that specific embodiments of the invention have been described herein for purposes of illustration, but that various modifications may be made without deviating from the spirit and scope of the invention. For example, aspects of the invention described in the context of particular embodiments can be combined or eliminated in other embodiments. Many of the steps are described above in a particular order for purposes of illustration, but can be carried out in other orders as well. Further details of electrode system, techniques for visualizing target implant areas, and techniques for implanting electrodes are disclosed in the following corresponding U.S. Applications, all of which are incorporated herein by reference: Ser. No. 10/731,731, filed Dec. 9, 2003; Ser. No. 10/910,775, filed Aug. 2, 2004; Ser. No. 10/877,830, filed Jun. 25, 2004; and Ser. No. 10/731,852, filed Dec. 9, 2003. Accordingly, the invention is not limited except as by the appended claims.
|Citing Patent
|Filing date
|Publication date
|Jan 26, 2006
|Feb 2, 2010
|Cyberonics, Inc.
|Treatment of reproductive endocrine disorders by vagus nerve stimulation
|Jan 25, 2007
|Apr 27, 2010
|Cyberonics, Inc.
|Modulation of drug effects by vagus nerve stimulation
|Jan 27, 2006
|Sep 21, 2010
|Cyberonics, Inc.
|Controlling neuromodulation using stimulus modalities
|Oct 27, 2006
|Jan 11, 2011
|Cyberonics, Inc.
|Implantable neurostimulator with refractory stimulation
|Apr 28, 2006
|Jan 11, 2011
|Cyberonics, Inc
|Threshold optimization for tissue stimulation therapy
|Nov 25, 2013
|Aug 18, 2015
|Dignity Health
|Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Oct 17, 2006
Owner name: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, JAPAN
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Effective date: 20060801
|Jun 12, 2009
Owner name: ADVANCED NEUROMODULATION SYSTEMS, INC.,TEXAS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:NORTHSTAR NEUROSCIENCE, INC.;REEL/FRAME:022813/0542
Effective date: 20090521


text:
Participants will live in a student residence. All students will be assigned double rooms at the residence and will be able to request a roommate.
You will most likely arrive at Charles de Gaulle Airport (CDG). This airport is also known as Roissy and is located 23 kilometers (14 miles) northeast of Paris. When you exit baggage claim into the main hall of the airport, follow signs for SNCF/RER. You will take Line B, the only line that serves the airport, and get off at Gare du Nord. At Gare du Nord you will change to Line 5, direction Place d'Italie. Then you will get off at République and change to Line 8, direction Créteuil-Préfecture. You will then get off at Montgallet. When you exit the metro station you will be on Rue de Reuilly.
The Résidence Vivaldi is at 102 Rue de Reuilly. The residence is in the 12e arrondissement between the metro stops Montgallet and Daumesnil on line 8. A ticket for the RER costs about 8 Euros and can be purchased at the guichets (windows) near where the train leaves. You can also take a taxi (approx. €40 – 50) or hire an airport shuttle.
Métro (within Paris city limits) - are designated by numbers. You find your line by the destination (the last stop on the line). Vous prenez le métro direction "Porte d'Orléans".
RER – light rail system that serves the suburbs of Paris, stops within Paris as well, RER lines are designated by letters (A, B, C, D, E). This is what you will take to/from the airport.
Buses - Buses will also take you anywhere in Paris and are a nice way to explore the city. The 46 bus goes directly to the ESCP-EAP.
Metro/RER/Bus passes (weekly or monthly) available and are cheaper than buying tickets every day. Your metro pass is good for the metro as well as buses. Maps are also available in any Metro/RER stations. Most of you will want to purchase a Carte Orange.
More Info: www.parisinfo.com
Page last updated:


text:
|Resume Seminar
Event Type: Computer Literacy & Training
Age Group(s): Adult Program
Date: 4/15/2013
Start Time: 5:30 PM
End Time: 7:30 PM
Open to adults. Registration required & begins two weeks before each session. Learn how to create a resume. Please bring a list of previous employers with addresses & dates of employment and list of schools attended with dates.Library: Atlantic County Library System / Galloway Township Branch Map
Location: Small Meeting Room
Contact: Galloway Township Branch
Contact Number: 609-652-2352


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text:
Dear Ms. Vicki,
I don't know what to do. I am not currently in the service, but I wish to join the Navy as an advanced electronics technician. I am recently engaged and my significant other wants to support me. But she also hates the idea of me leaving her.
My fiancee doesn't think I should go into the military. I want to serve. So I'm not entirely sure about what I should do. I mean, when we were discussing it she almost broke down and started crying. I think she would get over it, but I'm not sure.
Very Confused Fiancé
Dear Confused,
This is a very important question and something you should seriously think about. Here goes my quick answer: If you are not sure, then don't do it. Period.
You have to know that you are making the right decision before joining the military. Yes, your girlfriend may be taking it hard and she in turn may like the Navy life in the long run. There is no way to know for sure.
Let's face it: Life happens. Suppose she never likes it? Suppose you join and you don't like it? What happens then?
Honestly, I think it is your own ambiguity that has me more concerned. Take your time. Perhaps you really don't know if you should join the Navy right now and that's OK. Let me know what you decide to do.
Ms. Vicki
Dear Ms. Vicki,
My friend's husband got back from Kuwait and immediately started divorce proceedings. Tricare Health has stopped her spousal insurance and refuses to send her any supporting documents.
She can't get on state insurance until Tricare sends a letter explaining she is no longer on her husband's policy. Every time she or her worker phones, Tricare says the same thing: "Contact the husband. He has to ask for her."
She can't afford an attorney because her husband is only giving her $200 in support. The divorce has taken a toll on her fibromyalgia and she is unable to work. She keeps trying to get her divorce finished, her healthcare locked down, and her life back on track yet the military keeps telling her to talk to her husband about support and documents.
How can she do this when he refuses to talk to her and mediation has failed? Is there a way she can cut through the red tape and start life again or does she have to submit to the silence of her husband?
Friend in Need
Dear Friend,
I am very sorry to hear about this and I really wish your friend the best. Urge her to get a divorce attorney who specializes in military cases.
One thing for sure, her husband is being a jerk and heartless by not giving her the information she needs so she can have access to healthcare. I think she has no other option but to try and get his unit command involved.
The command should tell him what he should do about supporting his wife and to release the information for her health insurance.
Readers, do you have more advice or information for others in this situation?
Ms. Vicki
Related Topics
|Family and Spouse
Ms. Vicki is a native of Dallas, is married to an active-duty Soldier and has three sons. She has a Master's of Science in Social Work from the University of Louisville, is a Licensed Clinical Social Worker and currently works as a therapist with military servicemembers and their families. She provides services for a wide array of concerns such as combat stress, PTSD, couples and marital problems, depression, grief and loss, stress and coping.
Ms. Vicki also writes an advice column "Dear Ms. Vicki" that appears in the Washington Times, the Fort Campbell Courier and the Heidelberg Herald Post. Ms. Vicki also hosts an internet radio show and blogs on her community site with the Washington Times. If you want to ask Ms. Vicki for advice about your military life, please email her at firstname.lastname@example.com.


text:
Browse and search white papers and mission & technology studies received by the Planetary Science Decadal Survey. Click here for basic user instructions.
Title: Near Earth Asteroid Trajectory Opportunities in 2020–2024
Primary Author: Erik Asphaug
Institution: University of California, Santa Cruz
Date: September 1, 2010
Summary: Near Earth objects (NEOs) are attractive targets for spacecraft missions with the purpose of obtaining greater insight to the nature of the original bodies from which the terrestrial planets formed, without having to visit the Main Belt itself. Greater knowledge of NEOs directly sheds light on the origin and evolution of the asteroid belt, the formation of planets, and the history of the solar system.
Panel Selection: Primitive Bodies
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These documents have been prepared in coordination with the National Academies of Science in support of the National Academies Planetary Science Decadal Survey. These documents are being made available for information purposes only, and any views and opinions expressed herein do not necessarily state or reflect those of NASA, JPL, or the California Institute of Technology.


text:
EVANSTON, Ill. – Indiana is back near the top of the Big Ten.
The Hoosiers' 67-59 victory at Northwestern Sunday gave them a 4-1 conference record, which ties them with Michigan and Wisconsin for second, a half-game behind 5-1 Michigan State.
Second-ranked Indiana (16-2) needed a bounce-back performance after losing to Wisconsin last Tuesday. It faced a Northwestern team that had lost its last two home games, and four of its last six at Welsh-Ryan Arena.
Reggie Hearn, a former Snider standout, led the Wildcats (11-8, 2-4) with 22 points, one off his career high. He has 42 points in his last two games.
Hearn played all 40 minutes. He was 7-for-12 from the field and 8-for-9 from the line. He added three rebounds, one assist and one block.
Hoosier forward Cody Zeller led IU with 21 points and 13 rebounds. Christian Watford added 14 points and six rebounds. Jordan Hulls had 15.
Indiana guard Victor Oladipo left the game briefly in the second half with a head/eye injury, but soon returned.
The Hoosiers needed him. He finished with seven points, six rebounds and five assists.
Indiana took charge early behind Watford, who once again got off to a strong start. The Hoosiers used a 9-0 run to build a 12-4 lead. They pushed ahead by as many as 15 points before settling for a 31-17 halftime lead.
IU shot 44.4 percent in the first half. Cody Zeller had seven points and eight rebounds.
The Hoosiers' recent second-half struggles resurfaced. They fouled early and often. Their lead was cut to six. But a big three-pointer from Oladipo and a mid-range jumper from Will Sheehey (who broke a two-game scoreless streak) helped IU hold on for the victory.
Its next game is Wednesday against Penn State.


text:
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text: Jane and Fischer investigate a murder at an oil fracking site, while Rigsby and Van Pelt travel to Austin to help investigate suspects in the string of attacks on former CBI team members, on THE MENTALIST, Sunday, March 16 (10:00–11:00 PM, ET/PT) on the CBS Television Network. Pictured: Owain Yeoman as Wayne Rigsby. Photo: Darren Michaels/Warner Bros. Entertainment Inc./CBS © 2014 WBEI. All rights reserved.


text:
I wonder if Paul Allen threw some money their way.
Great for their program. The Pac-12 is going to have some SIICK offenses next year.
I wonder if Paul Allen threw some money their way.
Great for their program. The Pac-12 is going to have some SIICK offenses next year.
Leach wasn't going to get a bigger job. Washington and Miami both were really turned off by Leach in the interview process. Maryland fired Ralph Fridgeon in order to hire Leach, but after interviewing him, they said no way in hell.
Wazzou needed to take a risk, and it's a tough place to recruit. Leach will be able to rebuild the Cougars like he did Texas Tech. And the athletic department is giving him nearly $2 million to hire his assistant coaches.
Texas A&M is also seriously considering firing Mike Sherman. SHerman has done a decent job bringing in talent switching the Aggies from a spread and 4-3 offense to a pro style and a 3-4. Problem is the team has underachieved the last few years and the big money boosters aren't happy, especially with the school moving to the SEC.
Former Hurricane WR coach Curtis Johnson will likely be named Tulane Head Coach
Great for Curtis Johnson. He was a terrific coach for us.
Looks like Carl Pelini will be the new FAU coach.
Arizona State has ended it's courtship of Kevin Sumlin, leading to speculation that Sumlin is going to be named A&M Head Coach soon. Sumlin is a former OC at A&M.
Larry Fedora is probably the hottest name on the market. Once seen as a lock to be named Ole Miss Head Coach, he's on the short list for Arizona State, and Kansas as well.
Along with Fedora, the Sun Devils are said to be looking at Mike Sherman, Ron English, Sonny Dykes, and Kliff Kingsbury
Interesting rumor going around is that Mike Munchak (Tennessee Titan's HC) has contacted his alma mater of Penn State to take over as HC.
Another rumor going around is that Mack Brown will retire after Texas's game.
Kirby Smart to Ole Miss?
He and Friedgen are having an "All You Can Eat" contest somewhere laughing at their last jobs.
Arkansas OC Garrick McGee takes on a difficult task; winning at UAB
I wonder who'll end up at Ole Miss? Hugh Freeze?
UCLA apparently was interested in Al Golden, but apparently got told to go **** in their hats.
Maybe they'll go after Steve Sarkisian next.


text:
The Bread Lover's Bread Machine Cookbook
Beth Hensberger has written 10 books on bread-baking which together have sold over 250,000 copies.
In this information packed cookbook, Hensberger offers, 300 well tested recipes for breads, cakes, rolls, jams, pizza and more... that can all be made in a bread maker. Yes every one. She shares, secrets tips, and advice appropriate for beginners or advanced bakers. The Bread Machine Cookbook is a must have companion for any household that owns a bread machine. This guide makes the process even easier than it is – no guesswork. There are clear, concise instructions for timing, ingredients and technique.
Try these bread maker recipes:
Cinnabun Coffee Cake
Win the Book ...We thank Harvard Common Press for sponsoring the Featured Cookbook and the FREE Giveaway!
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Browse and search white papers and mission & technology studies received by the Planetary Science Decadal Survey. Click here for basic user instructions.
Title: In-Situ Mass Spectrometry of Atmosphereless Planetary Objects
Primary Author: Eberhard Gruen
Secondary Author(s): Frank Postberg, Harald Krüger, Mihaly Horanyi, Elmar Jessberger Sascha Kempf, Ralf Srama, Thomas Stephan, Zoltan Sternovsky
Institution: LASP, University of Colorado
Summary: Dust particles emitted from atmosphereless planetary objects are samples of their surfaces. By mass analyzing these particles and tracing back their trajectories to their sources the surface composition of Mercury, planetary satellites, dusty rings sources, asteroids and comets can be obtained.
Panel Selection: Inner Planets: Mercury, Venus, and the Moon.
Giant Planets: Jupiter, Saturn, Uranus, Neptune, and exoplanets, including rings and magnetic fields, but not their satellites.
Satellites: Galilean satellites, Titan, and the other satellites of the giant planets.
Primitive Bodies: Asteroids, comets, Phobos, Deimos, Pluto/Charon and other Kuiper belt objects, meteorites, and interplanetary dust.
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These documents have been prepared in coordination with the National Academies of Science in support of the National Academies Planetary Science Decadal Survey. These documents are being made available for information purposes only, and any views and opinions expressed herein do not necessarily state or reflect those of NASA, JPL, or the California Institute of Technology.


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Department of Human Services
Families First Online Policy Manual
Child Care
In order to receive child care assistance, the child care must be necessary for the caretaker to participate in work activities. Child care is not provided if the caretaker can arrange for free care or the children are in school during the hours the client will participate in work activities. Child care assistance will not be given to a two-parent family (Unemployed Parent case, incapacity or married during receipt of assistance), if one parent is able, willing, and appropriate to provide care in the home. Child care will not be given to a minor parent who is an EC if the caretaker of the AU can provide the care.
Child care eligibility and the eligibility end date must be reviewed during each contact between the client rep and the participant. Bulletin 30, FA-11-19
Child care is available, if needed, on the first day of participation in an activity, employment or while the parent or caretaker attends FSC assessment. Bulletin 29, FA-08-21
Child care is available for all eligible adults (even if they are disqualified) if they are in a work activity. If the eligible adult is exempt from the work requirements, he/she may still be able to receive child care if he/she volunteers for a work activity or agrees to FSC assessment. Bulletin 29, FA-08-21
Child care cannot be provided prior to the approval for Families First, except when the caretaker is participating in an activity during the required 5-day compliance period to cure a sanction.
Child care assistance will be terminated for Families First participants who are non-compliant with their Personal Responsibility Plan.
If the participant makes contact, either during the conciliation period or at a later date, and is determined to have had good cause for the non-compliance situation, or agrees to comply prior to the eligibility termination date, the caseworker/client rep will restart the child care. Prior to restarting child care, the caseworker/client rep must determine that child care is still needed by the participant. Child care will be restarted with no break in coverage if immediate child care is required in order to participate. Otherwise, child care will be restarted effective with the date the individual has agreed to return to the activity.
If the participant fails to comply for the 5-day period, the child care will be terminated.
In the event the Families First case is being closed for cash benefits, and there is an open FF child care case, the child care case will be terminated effective with the date the adverse action period expires.
Exception: Families First participants, who are currently employed, will have a child care termination end date that corresponds with the effective date of case closure.
Child care will be provided for hours associated with the employment. This will allow participants to continue to receive child care uninterrupted while they are moved to Transitional Child Care (TCC).
At the time of approval, child care can be provided back to the date of application for the time that the participant was working or was in an activity that would qualify as a PRP work activity. The child care payments may be issued to the participant or the child care provider, as determined by the child care specialist. Retroactive Families First child care will not be provided if:
· The participant chose the child care disregard for the months in question.
· The AU was eligible for TCC during the application period.
· The AU was ineligible for cash payment, unless the individual was complying for 5 days to remove a sanction.
Child care will be provided, if needed, while a parent is in a drug/alcohol or mental health treatment program.
Child care will not be terminated when the caretaker is between work/training activities. The provider will retain a child care "slot" for the child for thirty days. If the break between activities will last more than thirty days, the child care should be terminated.
Retroactive cash reimbursement will be authorized to a caretaker who verifies he/she paid child care costs during a period of Families First eligibility and received no disregard and no direct payment was made to the provider by DHS during that time. This reimbursement cannot exceed the State allowable rate for the type of child care provided. The caretaker will be referred to the child care specialist to request the reimbursement.


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Just think if Arnsparger had stayed and not taken the LSU job. I believe we could have won a few more SBs and Dan would not have the *"yeah, but he did not win the SB". Do not know why the thought popped into my head.
Just think if Arnsparger had stayed and not taken the LSU job. I believe we could have won a few more SBs and Dan would not have the *"yeah, but he did not win the SB". Do not know why the thought popped into my head.
"It happens all the time," Taylor said. "It's not an exact science and personnel guys aren't the end-all, be-all. " Jason Taylor,2011
Well, if Larry Z, Paul Warfield and Jim Kick hadn't left when they did, we probably would have won a couple of more superbowls in the 70's. But it is what it is and it's been 39 years since we won one. That's why nobody can't blame the fans for being upset with our team.That's why I laugh everytime I hear that it takes time. It's been 39 years and counting.
Ozzy rules!!
You know, this isn't such a wacky thought. In 1983, Marino's rookie year, the Dolphins set the team record(since broken) for sacks. They had the number one defense in the league. They made the playoffs but got upset in a sloppy game at home vs. Seattle. I was in 10th grade and it made me sick.
After that season, Arnsparger left.
We all know about 1984. Marino totally lit things up, but throughout that season the defense, now under Chuck Studley I believe, started to struggle. As the season went on, it became softer and softer and before the last game of the season, Monday night vs. Dallas at home, the defense had a players only meeting to try to get things straightened out. The Dolphins won the game, and of course the next two playoff games, but there was still lots of talk about how their defense was struggling. In the Super Bowl, it was 10-7 Miami at the end of the 1st quarter, but the 49ers scored 21 points in the second. We added a couple of field goals, but at 28-16 at the half the Niners had all the momentum and had totally beaten us down. Had Arnsparger been around for that 1984 season, I wonder how that Super Bowl would have gone. Could the game have been closer at the half? That game felt over by halftime, but maybe in a 21-13, or 21-16 game, had we allowed even one less touchdown, it would have been totally different. I remember that season so well, watching the Dolphins whenever they were on TV(No NFL Ticket back then!) and I have every victory from that season on DVD and I've seen them several times. That season was great until the end, but it is a good point about what could have been.
The pleasure of what we enjoy is lost by wanting more.
-A fortune cookie
Oh and I was in 11th grade in '83.....my how time flies!!!!
Why Shula kept Tom Olivadotti around for all those years is a mystery to me. The Steeler's Dynasty of the 70's may never have happened had the WFL not scooped up Csonka, Kiick and Warfield. I think the Steelers may have still won a couple SB's, but not four SB's in a period of six years.
We had no speed on d at all in 84, we were built to stop the run, and Montana lit us up in the sb! Why we kept olivadotti so long is beyond me! Shula must've really love him.
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I wasn't old enough to be in depth in 83 and 84. I was a fan but a kid so I didn't think about things like who the defensive coordinator was. I was more enamored with Marino's name ending in a vowel and the same vowel as mine lol.
I know one thing had Miami played D like they did in Marino's rookie year for the next 10 they would have won a few more super bowls.
"Frank's Redhot - I Put That **** On Everything!" ~ Ethel
This is a great thread, makes us old timers proud to be old timers. I was 11 years old when the Dolphins went to their first Super Bowl; it was a great Sunday, until they played the game. I was so sad and upset! The next two years were great of course, two Super Bowl wins, three straight Super Bowl appearances, life was good. Then boom, damn WFL took away three of the best players we had, as a young kid I couldnt understand why they would leave this great team, my team. Obviously I was too young to understand the business end of school yard football. When we got Dan and he started lighting things up, it was fun football again. You knew that you always had a chance to win the game. All we needed was a little better running game, which would help run time off the clock and at the same time help rest our defense. I do agree that as great as Dan was, sometimes we scored to quick and our defense would then be back on the field to soon without rest. Not as big of a deal early in the season, but late in the season everyones banged up. I wish Arnsparger had stayed, I agree that the defense was without a doubt different, they lost their Arnsparger Swager!!!


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Final two games of the USC Upstate series cancelled due to field conditions
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Sunday, March 06, 2011
SPARTANBURG, S.C. (March 6, 2011)
- The final two games of the USC Upstate series in Spartanburg, S.C. have been cancelled due to field conditions after steady rain in the area over the past couple days.
The Bucs return to action on Tuesday at 6:05 p.m. as they play host to Furman in a non-conference matchup. For more information on ETSU baseball and all other Buccaneer athletic news please visit www.ETSUBucs.com.
Copyright ©2015 East Tennessee State Athletics. All Rights Reserved.


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A new home test for Alzheimer's, Sen. Elizabeth Warren talks about Alzheimer's diseases and NIH funding, and more on Roche's brain shuttle (read more).
The need for the US to mobilize a world effort against Alzheimer's, Cokie Roberts advocates for NIH funded research, and the need for more doctors to tackle diseases like Alzheimer's and diabetes (read more).
Must read opinions
Roche develops new drug delivery system that might lead to more effective treatments for Alzheimer's, the impact of cuts to biomedical research, and do phone apps and computer games really keep your brain healthy? (read more)
Must reads
Read the full piece online here.
Korea's dementia crisis, the need for global action against Alzheimer's, and one Seattle politician resigns due to Alzheimer's (read more).


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A new report warns that insurance companies — perhaps more than initially thought — may be charging the sickest patients extra for drugs under the federal health law to discourage them from choosing certain plans.
Shasta Regional Community Foundation is excited to announce its new online application platform for grant proposals.
he Siskiyou Branch of American Association of University Women is presently launching its recruitment effort for the Summer 2015 Tech Trek, the science and math camp for girls.
A law enforcement campaign to compel Google Inc. to disable a feature in its popular Waze traffic app that lets drivers warn others about nearby police activity shifted Wednesday when a sheriffs' organization openly complained that the app not only...
As the United States forges closer ties to India, neighboring Pakistan is looking for some new friends. Officials hope they have found one in Russia — a budding partnership that could eventually shift historic alliances in South Asia.
Journey to the frontier of food and you'll find a 3D printer, spewing out chocolate. While traditional cooking isn't going anywhere, you can count on 3D printed foods eventually finding a place in our world.
Today in fanfic comes to life, Taylor Swift and
Broadway legend and Oscar-winning star of Cabaret Joel Grey has come out as gay.In an...
- Events Calendar


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We lost the game and that's all that matters. Lets try to keep some standards around here.
We lost the game and that's all that matters. Lets try to keep some standards around here.
so no one noticed the part where he said they have no household names? thats the biggest key there. This team has lacked 1 household name since JT left Miami.
This article means crap, we didnt make the playoffs and we are a below 500% team.
negative? I SPOKE THE TRUTH.
I dont understand how people are "HAPPY" to see us being a bloew 500 team as long as someone says something good about us.
To me WINS PLAYOFFS CONTENDING SUPERBOWL MAKES ME HAPPY NOT BELOW .500 WITH A GOOD REVIEW FROM A COACH but thats why I strive to be GREAT not average, if everyone had that personality there would be millionaires all over the world.
Last edited by Valandui; 01-30-2013 at 06:45 PM. Reason: Personal Attack
Yeah obviously last year we didn't get the job done. Everybody knows that.
But we are not going to be the same team next year.
People are just happy because we have some awesome pieces going forward.
This was actually a pretty cool article, not the run of the mill ****.
Last edited by sirvmac; 01-30-2013 at 07:12 PM.
This season was about development. And Tannehill did just that. Now keep your heads in the clouds thinking MIA was a SB team this year.
In the real world there are moral victories. No team goes 19-0 every year. Would I have rather won more than 7 games ?, of course, but I think this franchise is on the right path, and that is all that I ask. Do I expect the Phins to compete for a Superbowl next year ? No, but if this team keeps growing, and we catch a couple of breaks, I think we can be really good in 2015-16.
I still kinda believe, I think
Gives some confidence about the future. The key is being able to keep our defense together. We must resign Clemons and sign Jones long term. Then develop a plan about our LB's and DL since several of them are going to be FA's next year.


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This story was updated at 2 p.m. Sept. 11, 2013.
A man has died after his car struck a tree on Laytonsville Road in Damascus on Wednesday morning.
After a preliminary investigation, police believe that Adam Joseph Gaudreau, 48, of Mount Airy, was driving east on Laytonsville Road when his car drifted from the road, hit a large tree and rolled over, according to a police news release. Gaudreau was the only person in the vehicle, a gray 2009 Hyundai Sonata, at the time of the crash.
Emergency responders flew Gaudreau in a Maryland State Police helicopter to R Adams Cowley Shock Trauma in Baltimore where he later died.
The crash happened on Laytonsville Road near Hawkins Creamery Road in the Damascus area. Police temporarily closed a portion of Laytonsville Road between Hawkins Creamery and Damascus roads while the Collision Reconstruction Unit investigated the crash, but the road has since re-opened.
Police do not yet know why the car drifted from the road, the news release said. They are asking anyone with information about the crash to call the Collision Reconstruction Unit at 240-773-6620.


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The COOP, the Career Center, and the Levitt Center are teaming up to educate the campus community about Social Innovation and Social Entrepreneurship.
Read George R. Roberts' article in the Wall Street Journal: The Social-Enterprise Approach to Job Creation - Helping people stay in school, out of prison and off the government dole.
Social Innovation and Social Entrepreneurship programming is co-sponsored by: The Levitt Center, the Career Center, and the COOP
October 20 & 21, Colgate and Hamilton Students participated in StartupX, a social entrepreneurship workshop held on Colgate's campus. During the program, students worked in teams to learn about problem identification, tech trends, design thinking, business model innovation, customer development and pitching, and to gain the confidence to create a real viable startup. Read about the experience here!
Visit the StartupExperience website for more information.
"The Levitt Center, in partnership with the Career Center and COOP, had the privilege of inviting alumnus Chuck Harris to deliver an insightful lecture on Social Entrepreneurship at Hamilton on Thursday, February 28th. Harris, as both a past partner and managing director at Goldman Sachs and current Portfolio Manager and Director of Capital Aggregation at The Edna McConnell Clark Foundation, provided great insight into entrepreneurship in the world of profit and non-profit organizations. As Harris pointed out however, the lines between business and charity in modern times are blurring. Harris not only shared some of his past and present work, but also provided budding student entrepreneurs with valuable information on what it takes to become a successful entrepreneur in the twenty-first century." Read about the experience here.


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The words Beverly Hills are synonymous with wealth, and there's good reason for that. Since silent screen stars Douglas Fairbanks and Mary Pickford settled there in 1920, the area -- a separate municipality, actually, in the middle of L.A.'s westside -- has been known as the stomping ground of the rich and famous. These days, it's increasingly more the rich, and less the famous, who live in the mansions in the sprawling residential portion of the city, between Santa Monica and Sunset Boulevard. Still, there's enough star power around to merit sightseeing tours of the stars' homes in the area. South of Santa Monica lies the main commercial district, a pedestrian-friendly set of streets known as the "Golden Triangle" and bound by Wilshire Boulevard, Canon Drive, and Little Santa Monica. It's home to Rodeo Drive, that famed stretch of luxury shopping that includes seemingly every designer boutique, from La Perla to Louis Vuitton. One block over, Beverly Drive houses more affordable upscale shops, like Anthropologie and Crate & Barrel. The area is also home to a number of great restaurants, from fancy upscale dining like Wolfgang Puck's Spago, within the Golden Triangle, to famed sushi spot Matsuhisa, farther to the east on La Cienega Boulevard. Fear not, there are also a number of spots to grab a cheap lunch or quick cup of coffee, including a Coffee Bean & Tea Leaf. These spots mostly cater to the working crowd toiling away in nearby office buildings -- home to companies such as the talent agencies William Morris and Endeavor.
Most Beverly Hills hotels fall into one of two categories: large, expensive icons or stylish boutique properties. In the former category, The Beverly Hills Hotel, built in 1912, is a pink-and-green palace of luxury, set on twelve secluded acres with a beautiful pool, a five-minute drive from Rodeo Drive. Equally iconic, the stately Four Seasons Beverly Wilshire offers a more urban take on luxury, sitting right on Wilshire Boulevard, across the street from Rodeo Drive and just down the street from huge upscale department stores like Saks Fifth Avenue. Smaller, more affordable boutique properties like Luxe Rodeo Drive and Maison 140 have great locations within the Golden Triangle and lovely style, but few amenities (no pool at either) and tiny standard rooms.
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text: Le Moyne Book Club: May 15 Come join the Le Moyne College Book Club on Wednesday, May 15 as we discuss Mohawk by Richard Russo. We will be meeting in the Bernat Special Activities Room in the Noreen Reale Falcone Library from 7-9 pm. Refreshments will be served! Please contact Kari Zhe-Heimerman (firstname.lastname@example.com) with any questions. Posted in: Events, Book Club on April 09, 2013 09:08 E-mail to a Friend | Permalink | Retweet | del.icio.us Current Articles | Archives | Search


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I arrived in London yesterday for the Olympics. There's so much energy and excitement in the air. This is a very special time to be in London and I feel privileged to be here.
I've dreamed about playing in the Olympics for many years, and withdrawing from the 2008 Beijing Games was probably the toughest moment of my career.
Being in the Olympic Village in China, with all the other athletes, and practising at the facility, it just adds to my expectation and eagerness to step onto court here to compete.
I wasn't sure if I should call this a summer update or spring: it is June, after all, but I've just arrived in London and it's hard to say that it's summer!
Everyone is telling me what terrible weather it's been in England lately: I hope it improves in time for the grass court season but it doesn't look very promising.
Mind you, it wouldn't feel like England if it was amazing sunshine every day: I have become used to this weather during all the trips I've made here since I was a junior.
As I write this I still feel a lot of frustration regarding my Indian Wells semi-final. I felt like I was playing very well and had a good chance to win it when I became injured. I know it's part of the sport, and it's probably the most difficult part!
I leave Melbourne with mixed emotions, but overall I'm happy. I played some good tennis and only lost to a great player who is maybe the very best on the Tour at the moment.
It's been an exhausting month of tournaments. I played three tournaments in a row and it took a lot out of me. I've decided not to go back to Europe for the Fed Cup. I've only just recovered from the virus I picked up during the Australian Open, and I'm going to be very careful with my schedule and traveling this year, considering the Olympics and the packed summer months.
It's almost here! I can't say I was bored during the off-season, because I have really enjoyed my time in Australia so far, but I've really missed competing.
I came to Australia straight from Bali actually, and spent time with Adam at tournaments in Sydney and Melbourne. I also visited my family in Melbourne.
What an exciting end to the season that was. Often, after the US Open ends, thoughts turn straight away to the following season because that's when the next Grand Slam takes place: the majors are always my main focus.
It's been a very eventful few weeks – a lot has happened since I last wrote.
A few months ago I decided I needed to appoint my own coach, but the most important thing was that I chose the right one. I was prepared to wait for that, and I'm fortunate that I am working with Nigel Sears with half of the season still to go.
I'm also very happy to have Scott back in the team, as my fitness trainer. We've always got on so well and achieved some very good results together. He knows me as well as any coach and I'm confident that he can help me achieve my goals.
A lot of people this week have commented on what a dramatic tournament it has been already. The Venus-Date match was an obvious highlight and there have been a lot of exciting matches. Personally, I have had two thrilling match days, mainly because of the weather.
It's taken me a few days to get over my defeat on Sunday. It's a tough one to explain: I was in control of the match, leading by a set and a break, but I somehow lost confidence and Mattek-Sands took full advantage.
I'm often asked by friends what the locker room at a tournament looks like. They really vary, to be honest: at a Grand Slam they are large and there are usually two of them, whereas at smaller tournaments they are far more compact, usually with just the bare necessities. At the larger ones there are sofas and I've even seen a hot tub.
I like to relax as much as I can before a match, so I try to find a peaceful space. I will often sit on one of the sofas and read a book while I'm waiting for my match to be called.