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It's been nearly six years since Janice Y.K. Lee made her fiction debut with The Piano Teacher, an "exceptional first novel" set in postwar Hong Kong where Allied occupiers and the native people negotiate an uneasy peace and a brittle, stratified society (read our review). The novel was favorably reviewed and a national bestseller, so we're pleased to hear that a follow up, The Expatriates, will be coming in January from Viking.
Also set in Hong Kong and featuring a cast of expatriates, this novel is set in the modern day, and "explores with devastating poignancy the emotions, identities, and relationships of three very different American women living in the same small expat community in Hong Kong," according to the publisher.
Will you read it?
British author William Boyd returns this fall with his most sweeping, ambitious work since 2002's Any Human Heart. Sweet Caress, which Bloomsbury will publish in the USA on September 15, tells the story of the 20th century through the eyes of a remarkable female photographer, Amory Clay, born in 1908.
The novel is punctuated by authentic vintage photos, chosen by Boyd from thousands of images found in "junk shops, estate sales and the like," according to his publicist, Summer Smith. These images make the story feel even more real—blurring the line between fiction and reality.
Anyone else looking forward to this one?
RELATED CONTENT: Read more about this year's fall fiction releases.
Best-selling author Pamela Schoenewaldt's new book tells the story of a German-American girl whose life is changed forever by the outbreak of World War I. In a guest blog post, Schoenewaldt shares five surprising facts about the German-American experience on the homefront during WWI.
My writing and research process for Under the Same Blue Sky (Morrow) was flavored by stories of relatives who came from Germany between 1870 and 1900. I was curious about their experience during World War I, when their native country and culture was vilified as the home of Huns, brutes and monsters. My great-grandparents, quietly harvesting corn in Iowa, must have been so astonished, so perplexed.
Naturally, my research went beyond family tales, but here are a few surprising facts about German-Americans during World War I.
German-Americans are the largest self-reported ethnicity in the United States
In 1910, nearly 10% of Americans were born in Germany or had German parentage. In much of the Midwest, German-Americans made up more than a third of the population. Most major cities had a significant "Germania" neighborhood. Assimilated and widely respected, German-Americans were spared much of the discrimination suffered by other immigrants. All that changed during World War I.
Immigrants were encouraged to let go of the past to become American
We all know the story of how our national identity was founded on the idea of a nation of immigrants, a golden gate typified by the Statue of Liberty, dedicated in 1886. By 1910, for various reasons, the mood had changed. Ever-more restrictive immigration policies were put in place. German-Americans, like Greek, Italian, Polish or Scandinavian-Americans, were often regarded with suspicion by many whose parents or grandparents had themselves been immigrants. President Wilson warned that "true" Americans give up their heritage. They close the door behind them. They forget where they came from. Imagine how that felt.
A telegram sent the U.S. into the war
The U.S. stayed neutral for the first three years of World War I (while making huge profits in munitions sales). Many German-Americans were even convinced that we'd ultimately side with the Kaiser. Then came the Zimmerman Telegram of 1917, a coded message from Arthur Zimmerman, the German foreign secretary, to the German ambassador to Mexico, offering to support a Mexican attack on the U.S. In return, Germany would reward Mexico with the return of Texas, New Mexico, Arizona and California.
In retrospect, the plan seems hardly credible: Mexico didn't begin to have that kind of military power, and Germany was a tad busy in Europe. Still, the effect was electrifying. Suddenly, people looked at their German-American neighbors as potential traitors and enemies. Within weeks, we were at war.
Thanks to war propaganda, German-Americans became suspect
Newspapers, posters, schoolteachers, songs and speakers whipped up the public against "the Hun." Speaking German in public was suspect, sometimes illegal. German-Americans were forced to demonstrate their loyalty by buying war bonds, sometimes bankrupting themselves. Some were made to crawl across factory floors to kiss the American flag. Patents by German-American inventors were taken away. Business were ruined, people beaten up, tarred and feathered, run out of town, sometimes killed. It's an ugly story, repeated so often in human history, when public policy shatters peaceful communities.
The German-American cultural community and identity were in many ways devastated by the war
Nearly 1 million German-Americans "disappeared" in the 1920 census because they claimed other ethnicities. Many German newspapers, community and cultural organizations never reopened, or never regained pre-war status. Music by German composers had been banned. Bach and Beethoven only slowly returned to repertoires. Yes, we won the war, but included in the collateral damage was a huge cost in cultural diversity and the richness in our communities.
Thanks, Pamela! Under the Same Blue Sky is now on sale; find out more on the official website or at these retailers: BAM | B&N | Indiebound | Amazon.
Author photo by Kelly Norrell
Few things are better than sinking into a lush, well-wrought historical novel. From 16th-century England to 1960s America, we've rounded up 15 of our recent favorites.
Viper Wine by Hermione Eyre
There's a price to be paid for beauty in this debut based on real events in King Charles I's early 17th-century court. The beautiful but aging Venetia Stanley is terrified that her looks are slipping away and turns to potions and creams to keep her youthful glow. But as the ladies of the court come to discover, beauty can be toxic.
At the Water's Edge by Sara Gruen
The Water for Elephants author travels to Scotland during the height of World War II in her latest novel. Naive and kind-hearted Maddie sets out to join her rich husband and his friend in their search for the Loch Ness Monster and falls in love with the Scottish countryside. However, soon it dawns on Maddie how ridiculous her husband and his quest are, and things take a dark turn.
The Fair Fight by Anna Freeman
Ladies, let's get ready to rumble! We've been waiting for this book to land in our office since last fall, and it did not disappoint. Although, as a novel based on real events in women's bare-knuckle boxing in late 18th-century England, how could it?
The Tutor by Andrea Chapin
If you're a Shakespeare lover like me, The Tutor is right up your twisty London alley. The novel follows the relationship between the widow Katharine de L'Isle and William Shakespeare—a relationship that brings the Bard's writing to new heights.
The Architect's Apprentice by Elif Shafak
Shafak, a Turkish native, explores the beautifully lush world of the Ottoman Empire in her latest novel. Arriving in court as a young boy, Jahan gradually finds himself in the inner-circle of the Sultan's premier architect, helping to build some of the most magnificent buildings ever seen. However, jealousy threatens to dismantle the two architects' accomplishments.
Into the Savage Country by Shannon Burke
In 1826, the American West was a rugged landscape filled with potential as well as danger. William Wyeth, a young man set on earning his fortune in fur-trapping, sees this firsthand as he delves deep into the territory, finding love, friendship and of course, encountering near-death experiences.
Driving the King by Ravi Howard
In a fictional account of the life of Nat King Cole's driver, Howard explores the tumultuous landscape of 1960s America. After saving Cole, his childhood friend, from an attacker during a performance in Montgomery, Alabama, Nat Weary is rewarded with a 10-year jail sentence. But upon his release, Cole offers him a job as his driver and a chance to travel through the changing country.
Wolf Winter by Cecilia Ekbäck
When you live in an isolated village in 1717 Finland, you really have to be able to rely upon your neighbors. Unfortunately for newly settled Maija and her family, one of these neighbors is discovered dead, a devastating winter is unfurling and things just get weirder from there.
Fiercombe Manor by Kate Riordan
England in the 1930s was not a hospitable place for a woman pregnant out of wedlock. When Alice finds herself in this predicament, her mortified parents ship her off to lonely Fiercombe Manor, where she will wait out her pregnancy and then give the child up for adoption. But there's something strange going on at the manor, and its secret history has disturbing implications.
The Magician's Lie by Greer Macallister
Accused of murdering her husband (onstage, no less), the Amazing Arden, a famed magician in the early 1900s, must convince a young policeman that she is innocent. Or is her plea just smoke and mirrors? If you enjoyed Water for Elephants or The Night Circus, this book's for you.
The Last Flight of Poxl West by Daniel Torday
Daniel Torday blends two coming-of-age stories in this powerful debut novel about truth and memory. As a teen, Eli Goldstein adored his Uncle Poxl, a Czech Jew who served in the British Royal Air Force during World War II and lived to write a best-selling memoir. But as Poxl's story unfolds, it gradually becomes clear that the past may not be as straightforward as he presents it. Torday excels at depicting the struggles of everyday people facing devastating airstrikes, and Poxl's unusual perspective makes the novel feel fresh.
West of Sunset by Stewart O'Nan
Travel back to the golden age of Hollywood with a washed-up F. Scott Fitzgerald in this poignant novel from O'Nan. His former literary fame and fortune shattered, Fitzgerald heads to Hollywood to try his luck at screenwriting. There he rubs elbows with silver screen queens and kings, even as he spirals deeper into despair and the alcoholism that will eventually kill him.
Citizens Creek by Lalita Tademy
The lives of a slave named Cow Tom and his granddaughter Rose unfold in this novel set in the 1800s American West. Cow Tom has an uncanny talent for mastering languages and is sold as a translator to the Creek tribe at a young age. Inspired by the strength of her grandfather, Rose is determined to keep her family together and thrive despite living in a hostile, violent world.
Vanessa and Her Sister by Priya Parmar
Parmar explores a world of literary stars in her second novel. The Bloomsbury Group was a set of thinking elite in early 20th-century London, with Vanessa and her sister, Virginia Woolf, among the founding members. Basing her novel off of Vanessa's letters and diaries from the time, Parmar offers up a fascinating fictional account of these privileged, clever and troubled bohemians' lives.
Miss Hazel and the Rosa Parks League by Jonathan Odell
Although they seemingly have few things in common, a white woman named Hazel and a black woman named Vida are linked by the devastating deaths of their young children. As they grow closer through this tragedy in pre-Civil Rights era Mississippi, Hazel's eyes are opened to harsh realities about society.
Not enough? See even more suggestions here, and check out our list from last year here.
The list of books to look forward to this fall just got a little bit longer: Pulitzer Prize winner Geraldine Brooks will publish a novel based on the life of King David, The Secret Chord, on September 22 with Viking.
The novel will be narrated by Nathan, the biblical prophet Brooks has described as "the keeper of the king's conscience." Though it is impossible to call a choice of subject for a Brooks novel predictable—all four of her previous books have had vastly different settings—the theme of faith is a recurring one for the author. As she told BookPage in 2005, "I'm intrigued by people who have strong beliefs, because I don't."
David is an Old Testament figure who appears in Judiasm, Islam and Christianity, and it's a safe bet that Brooks—who has studied Arabic and worked as a Middle East correspondant for the Wall Street Journal in the 1990s—will draw from all three traditions for her portrayal of the legendary king. And of course, he's a popular subject in art, film and literature, from Dryden to Faulkner.
Will you read it?
RELATED CONTENT: More on 2015 releases here.
Samantha Norman didn't plan to be a novelist, but when her mother, the best-selling writer Ariana Franklin, passed away in 2011 and left a half-finished manuscript, Norman felt called to carry on her mother's legacy. In a guest blog post, she reveals what it was like to finish The Siege Winter.
Guest post by Samantha Norman
When my mother, the best-selling historical novelist, Ariana Franklin, died suddenly and unexpectedly four years ago, she left a great big hole in my life and a half-finished novel.
Although she'd always nagged me to start writing novels of my own—convinced somehow that I'd inherited her talent—I never got round to it. I'd written features, lots in fact, for newspapers and magazines but never anything longer than about 1,500 words and had no particular desire to, either. Writing is hard—I'd done enough of it to know that much—and, what's more, I'd seen my mother—both parents actually, my father is also a novelist—sweating blood over their work and I just didn't feel that that sort of hard labour was for me. And yet all of a sudden my Mum was dead and there was a novel to complete and I was suddenly imbued with a zeal I'd never felt about anything before, absolutely determined that I was to be the one to finish it.
It was an enormous responsibility. My mother had a large and devoted fan base whose members were vociferous in their admiration of her beautiful prose and unrivalled attention to historical detail and accuracy. Therefore, to do her justice—I should point out here that mum was an absolute pedant when it came to research and getting things absolutely right—and to continue her remarkable legacy without public outcries of "Shame!" I had to do a crash course in the medieval history she so adored, and in a matter of mere weeks—I had a fairly punishing deadline—assume a knowledge of 12th-century English history which she had carefully garnered over more than 35 years.
Not only that, but I also had to assume her writing style. I had always loved, envied even, the way she wrote, the seemingly effortless almost mellifluous way in which she strung words together, but could I emulate it? Well, only you can be the judge of that. The book's out now and I'm terribly proud of it and I hope, I really, really hope that my mum would be too.
The Siege Winter is on sale today. Find out more or order online from these retailers: BAM | B&N | Indiebound | Amazon
Author Jennifer Chiaverini is no stranger to research—she's included historical elements in many of her 23 novels. In her latest, Mrs. Grant and Madam Jule, she goes back to the 19th century to explore the life of First Lady Julia Grant and her slave, Jule. In a guest blog post, Chiaverini shares five of the most memorable tidbits from her extensive research.
guest post by Jennifer Chiaverini
In March 1865, only a few weeks before the end of the Civil War, the tempestuous Mary Lincoln accompanied her husband on a visit to General Ulysses S. Grant's military headquarters at City Point, Virginia, where she had a very public meltdown. In the thankless role of Mrs. Lincoln's hostess, Julia Grant tried to calm her, only to bring Mrs. Lincoln's wrath down upon herself. Mrs. Lincoln angrily accused the general's wife of coveting her place in the White House, a charge Mrs. Grant calmly denied—little suspecting that four years later, her husband would be sworn in as the 18th president of the United States and she would become First Lady.
This astonishing altercation between Mary Lincoln and Julia Grant has gone down in history thanks to the many eyewitness accounts recorded in letters and memoirs, but most people today don't know these five other surprising things about the famously friendly and admired First Lady Julia Grant:
1. Julia Grant was afflicted with strabismus, more colloquially known as crossed eyes.
Her vision was so impaired that she could read, write or sew only briefly before the strain exhausted her, so Ulysses often read aloud or wrote letters for her. She was self-conscious of her appearance, and whenever she was photographed, she almost always sat in profile in an attempt to disguise her condition. As Ulysses' fame grew and Julia became more of a public figure, she inquired about corrective surgery so that she "might not be so very, very plain." She was disappointed to learn that nothing could be done, for the operation could have succeeded only if it had been performed in childhood.
2. Julia claimed to experience prophetic visions and dreams
She was correct so often that her family learned to trust her intuition. In her memoirs, published 73 years after her death, she describes several unsettling premonitions that she later learned coincided with moments her husband had been in grave danger on the battlefield. In Washington a few days after Confederate General Robert E. Lee's surrender, she was seized by such intense, overwhelming dread that she begged Ulysses to depart for their home in New Jersey immediately. A few hours after their train left the capital, the actor John Wilkes Booth shot President Abraham Lincoln at Ford's Theatre.
3. Although Julia and Ulysses enjoyed a long and happy marriage, when they first fell in love, their families did not want them to wed.
Although Julia's mother thought highly of Ulysses and supported the match, her father argued that Julia's constitution made her poorly suited for the arduous, roving life of a military wife and suggested Ulysses marry her younger sister instead. When Ulysses rejected this proposal, Julia's father insisted on a long engagement while the enamored lieutenant was off serving in the Mexican War. For their part, Ulysses' staunchly abolitionist parents were appalled that their son intended to marry the daughter of Missouri slaveowners, and they refused to attend the wedding.
4. Throughout the Civil War, rather than remain safe at home, Julia often lived with her husband at military headquarters.
Ulysses hated to be away from his family, and as the army moved, he would summon Julia to join him as soon as he established a secure location. According to historian Candice Shy Hooper, during the four years of the Civil War Julia traveled more than 10,000 miles to be with her husband, sometimes through enemy territory. In an era when long-distance travel was difficult and exhausting even when the trains ran on time, the weather was fair, and the roads weren't thick rivers of mud, Julia—and her four young children, who often accompanied her—risked disease, death and capture whenever they journeyed between home and headquarters.
5. Although Julia was married to the commander in chief of the Union armies in the war that would end slavery in the United States forever, she herself kept slaves.
Her favorite maid—a woman also named Julia but usually called Black Julia or Jule—often accompanied her mistress when she joined Ulysses at military headquarters. Both women risked certain danger as they journeyed to and from the field of war, but for Jule, the hazards of travel also brought knowledge and opportunity, and she eventually made a daring bid for freedom. Though historians debate whether Julia or her father was actually Jule's legal owner, there is no doubt that the future First Lady benefited from the enslavement and exploitation of other human beings for almost 40 years.
Thanks, Jennifer! Mrs. Grant and Madame Jule is on sale today. Readers can find chapter one on Chiaverini's website, or look for the book at these retailers: BAM | B&N | Indiebound | Amazon
author photo by Steven Garfinkel
A Touch of Stardust by Kate Alcott
Doubleday • $25 • ISBN 9780385539043
Published February 17, 2015
order from: BAM | B&N | Indiebound | Amazon
It's Oscar Season, and if you have Hollywood on the brain, it's the perfect time to dive into Kate Alcott's new novel. In A Touch of Stardust, the author of The Dressmaker turns back the clock to the 1930s and puts readers on the tension-filled set of Gone With the Wind.
We see through the eyes of Julie Crawford, a would-be screenwriter who's still somewhat starstruck by the personalities she encouters during her work at the studio's publicity offices. But when Carole Lombard—who is currently involved with Clark Gable—hires Julie as her PA, the Midwestern girl starts seeing celebrities in a whole new light. But the magic of the movies persists.
Each morning, she pulled herself from bed and joined the cleaning ladies and the plumbers and other sleepy travelers on the 5:00 a.m. bus to get to the studio early. That way, she could step onto the back lot alone and be in the old South and feel the magical world of Gone with the Wind come to life. In front of Tara, the trees that had been fashioned over telephone poles looked real, and if she hadn't known the dogwood blossoms were made of white paper, the illusion would have been complete. It just took believing. She loved watching it grow—over fifty building façades now, and two miles of streets. It didn't matter that she walked in a landscape of glued plasterboard, a place of fake structures held together by little more than Selznick's frenzied dreams. It was vividly real.
What are you reading this week?
Kate Atkinson's stellar Life After Life was one of the best books of 2013. So the news that the Scottish author is returning with a companion story is most welcome to this fan. In A God in Ruins, which Little, Brown will publish on May 26, Atkinson tells the story of Ursula's brother, Teddy, the RAF pilot who played a key role in Life After Life.
From the catalog:
"For all Teddy endures in battle, his greatest challenge is facing the difficulties of living in a future he never expected to have. A God in Ruins explores the loss of innocence, the fraught transition from the war to peace time, and the pain of being misunderstood, especially as we age."
Author Sarah Kennedy set her thrilling new series during one of the most intriguing eras of British history—the Tudor era. It stars an "everywoman," Catherine, a former nun who has lost her vocation due to Henry's shift from Catholicsm to Anglicism. More than 400 years after this dynasty died out, why do they continue to fascinate? In a guest blog post, Kennedy—who holds a PhD in Renaissance poetry—explores this idea.
Guest post by Sarah Kennedy
Henry VIII. Anne Boleyn. "Bloody Mary" Tudor. Queen Elizabeth I. Shakespeare. Who doesn't love the Tudors? Or love to hate the Tudors? Lust, power, betrayal, the church, the state—they embody it all. The Tudor era still looms large in our imaginations, from The Other Boleyn Girl and Wolf Hall to Shakespeare in Love and Anonymous. We love to follow the intrigues, romances and betrayals of these glamorous historical figures. But why?
Henry VIII's six wives have always intrigued us, partly because there were so many of them and partly because each woman was different and had her own impact on the politics and religion of the time. How many times have we watched Anne Boleyn win the king then lose her head? We know what has to happen, but those of us who admire her pluck and daring are usually hoping, somewhere deep inside, that she'll make it this time, that she'll have that son or that she'll somehow escape to the countryside with her daughter. Those who favor Katherine of Aragon see her as the tragic heroine who led her people into battle and tried valiantly to be a successful queen over a foreign country—and with a husband who grew to despise her. Jane Seymour, of course, died providing the desired heir, who didn't live to be an adult, and she was followed by poor Anne of Cleves, destined to be known as the "mare of Flanders" because the king found her unattractive. Catherine Howard, the girl-queen who clearly didn't know what she was getting herself into, was summarily executed for misbehavior that the court seemed to wink at, and Catherine Parr, that strong-minded widow, managed to survive by playing to the aging king's ego.
It's the very stuff of drama—human personalities clashing and contending while the country reels from one religion to another. The royal characters of the Tudor era are both larger than life and real. They fight and they kill and they lie . . . and they love and dedicate themselves fiercely to their beliefs and their families.
And then there is the second generation: Edward the son, who suddenly falls ill in his teens and tries to "give" the crown to the tragic Jane Grey. The outcast older daughter, Mary Tudor, or "Bloody Mary," was the first real queen regnant in England, and her half-sister Elizabeth ruled over the island's "golden age"—but refused ever to marry.
The Tudor era was a time of massive change in Europe, but the family didn't last long, which is another reason we go back to them. The 16th century in England is dominated by Tudors, but after Elizabeth's death in 1603, they're gone. In a hundred years, everything has changed, and the Tudors almost immediately become the family of legend. Henry's break from Rome caused an upheaval in his country that rocked the very foundations of everyday life: the Church. Like us, people in Tudor England struggled with fundamental questions of belief and authority. What is the right relationship between religion and politics? What moral authority does the king have? What moral responsibility do people have to follow a leader they see as ungodly?
My first novel, The Altarpiece, tried to provide some possible answers, and the Cross and the Crown series follows a young woman who tries to make sense of her world and her God as she navigates the tricky waters of the Tudor court. Catherine Havens is a kind of everywoman. Like us, she wants to follow her conscience . . . and she wants to live a "good" life. And like us, she is trying to figure out what that life might . . . or must . . . or can be. Will her own intelligence be her guide? Or will she follow the dictates of her king?
It's a question we all still ask ourselves, and the Tudor era continues to offer a dramatic stage on which writers, filmmakers, and playwrights can play out these human spectacles. I also wanted to consider the particular problems for women, who were seen as inferior to men—but who governed and taught and led both king and country. My Catherine is strong-willed and educated: a true Renaissance woman. But she is still a woman, who must take care not to seem smarter than the men close to the king—or than the king himself.
Why the Tudors? They are close enough to us to show us versions of ourselves, but also far enough away in time that the picture comes more sharply into focus. We know what they should do, but we also know what they will do, and our pleasure come both from hoping that things will go better this time around and watching the tragedies and triumphs play out as we know they must. And when we close the book or turn off the film, we've learned more about our past—and more about ourselves here in the present day.
Thanks, Sarah! The second book in the Cross and the Crown series, City of Ladies, goes on sale today (BAM | B & N | Indiebound | Amazon) and the third book will be published in 2015. Find out more on her website.


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CHARLIE'S ANGELS Merchandise
CHARLIE'S ANGELS Merchandise
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About Our CHARLIE'S ANGELS Merchandise
Charlie's Angels, a popular crime drama which ran from 1976-1981, starred Farrah Fawcett, Kate Jackson, and Jaclyn Smith. The three women, upon graduating from the police academy, were hired as private investigators by Charlie Townsend, a mysterious investigation agency owner. With instruction from Charlie, the angels are sent to investigate and solve cases before time runs out. You may not get to be one of Charlie's Angels, but you can definitely look like one in these Charlie's Angels t-shirts.

subset: commoncrawl


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Office Communicator 2007
Microsoft Office Communicator 2007 is Microsoft's unified client enabling information workers to communicate in real-time using a wide range of modalities such as VOIP calls, audio/video/web conferencing sessions and instant messaging. Office Communicator 2007 and Office Communications Server 2007 integrate with a wide range of Microsoft Office applications and existing enterprise telephony infrastructure.
System Requirements:
Operating System: Windows Vista™ 32-bit (RTM) operating system, Microsoft Windows XP Professional with Service Pack 2, Windows 2000 Professional with Service Pack 4 (requires Microsoft® Windows Media® technologies player, version 9, and Microsoft® Windows® Installer, version 3.0 or later)
For connectivity, Microsoft Office Communications Server 2007 must be deployed in the environment.


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Mercedes boss Toto Wolff admits the Nico Rosberg-Lewis Hamilton rivalry could "get more heated"...
Mercedes boss Toto Wolff admits the Nico Rosberg-Lewis Hamilton rivalry could "get more heated" and has suggested the two could be allowed to go all out for the Drivers' crown once the team title has been secured.
Rosberg currently leads the Drivers' Championship by 11 points from Hamilton with Daniel Ricciardo from Red Bull another 60 points adrift, but the tension between the two Merc drivers has on occasion threatened to boil over.
Although the powers that be at Brackley insist their drivers are free to race each other on track, data is still shared between the drivers.
However, Wolff has indicated that could change once the Constructors' Championship is wrapped up.
"Yes, potentially it is going to get more heated, but if we carry on in performing as we do now I am still carefully optimistic that it is only up to the two of them in fighting for the World Championship," he told the official Formula 1 website.
"Then we get to a situation where we could discuss if we want to maintain the way we work with each other. Do we think it is beneficial for the car, the team, and both sides of the garage? Or do we want to recalibrate a little bit, because it is about the two of them and one remaining World Championship?' That is a question mark - I don't know, because I haven't been there yet. It is new ground."
There have been times when the Merc bosses were left worried that things could get out of hand with both Rosberg and Hamilton making controversial statements in the media, but Wolff says they have been warned about their conduct.
"For the drivers, it is about the Drivers' World Championship, but nevertheless you have to understand that there is a big organisation behind them - one of the biggest and most well-known brands in the world - and sometimes the team comes first," he said.
"That is clear and both of them acknowledge and accept that. This is very important. They recognise the historic achievements of Mercedes-Benz in motorsport, and they put their own place in the right context."
The Mercedes pair have provided a lot of entertainment so far this season though as they had plenty of on-track duels and Wolff feels it is good for the sport if they are allowed to race.
"I think it was very beneficial for Formula One and for Mercedes. We all loved the race, even if I got a couple of grey hairs during it," he said. "There is much more than our own little sporting agenda. There is F1 as a sport; the fans; the brands we represent.
"I think we owe it to everyone to let them race, especially in a season when it is our two cars battling out front. I could be very short-sighted and say I want to win the Drivers' and Constructors' titles, and this is how we do it: team orders, don't crash into each other, and carry it on like it was always done. But we are going into new ground.
"Until now it has functioned really well. Could it come to a point where we say it is difficult to manage? It could be, but I don't see it - not with the two of them."


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HARLAN — The Creston girls basketball team may have lost its regular season finale at Harlan 66-35 on Friday, but head coach Larry McNutt believes his team gained a lot of confidence from the way it played against the Class 4A No. 6-ranked Cyclones.
The Panthers trailed by just 11 at the halftime break, and had it not been for a pair of open 3-pointers for the Cyclones, it could have been a much closer game at halftime.
"I think it just goes to show them that they can play with the best of teams," McNutt said. "If you can play with Harlan for a half, you can play with just about anybody, because Harlan's one of the best teams in the state."
The Panthers put together a solid first half thanks to strong defense and 10-of-11 shooting from the free throw line in the half.
Creston had only five made field goals in the half, but got to the free throw line by getting penetration and working the ball inside.
"We were playing hard, competing," McNutt said. "Our post defense was pretty good for the most part. We didn't let their guards get layups. I just thought we competed and played hard. We shot free throws well. We only had five field goals in the first half, but we got to the line, and that really gave us an opportunity."
Despite giving up nearly six inches to the Harlan post players, the duo of senior Brianna Maitlen and junior Zaidy Frank battled hard inside to keep Creston in the game.
The pair combined for 12 points and 13 rebounds, while also playing strong defense against bigger opponents.
Sophomore Natalie Mostek led the Panthers with 13 points and also grabbed six rebounds.
Harlan pulled away in the second half, as Creston struggled to score from the floor, and only got to the free throw line three times, shooting 2-of-3 in the second half.
The Cyclones shot better than 50 percent for the game from the field, compared to just 22 percent for the Panthers.
Creston finishes the regular season with a 6-16 record, while Harlan improved to 19-2.
The Panthers travel to Glenwood to take on the Rams in first round Class 4A Region 7 action on Wednesday, with game time scheduled for 7 p.m.
"Hopefully we can carry that over into practice on Monday and Tuesday and play a good game on Wednesday," McNutt said. "An effort like this will help us Wednesday."
HARLAN (66) — Jess Schaben 12, Taylor Frederick 12, Josie Esser 8, Elle Kloewer 7, Jordyn Moser 6, Taylor Leinen 5, Liz Riessen 4, Ana Petersen 4, Taylor Wagner 4, Hannah Havick 2, Kayla Evers 2. Totals — 28 7-10 66. FG shooting — 28-54 (51.8 percent). Team fouls — 12. Fouled out — none.
CRESTON (35) — Natalie Mostek 5 3-4 13, Zaidy Frank 2 2-2 6, Brianna Maitlen 1 4-4 6, Taylor Briley 1 0-0 3, Chelcee Downing 0 2-2 2, Emma Johnson 1 0-0 2, Alli Thomsen 1 0-0 2, Brenna Baker 0 1-2 1. Totals — 11 12-14 35. FG shooting — 11-49 (22.4 percent). 3-point goals — 1 (Briley). Rebounds — 26 (Frank 8, Natalie Mostek 6, Maitlen 5). Assists — 8 (Downing 4, Maria Mostek 2, Baker 2). Steals — 3 (Maitlen 2, Johnson 1). Turnovers — 13. Team fouls — 15. Fouled out — None.
The Creston girls junior varsity ended its season with a 12-9 record after a 55-28 loss to Harlan.
"The JV struggled to match up in the post," said freshman coach Mallory Peterson, who filled in for JV coach Mendy McCreight. "We couldn't stop them down low. They pressed, and we didn't handle that well."
Sadie Jones and Taylor Briley each scored six points to lead the Panthers. Maria Mostek added five points.
CRESTON (28) — Sadie Jones 6, Taylor Briley 6, Maria Mostek 5, Jenna Taylor 4, Alli Thomsen 3, Gracie Russell 3, Camryn Somers 1. Rebounds — Jones 6, Taylor 4. Steals— Russell 3, Somers 2. Assists — Briley 3.
The Creston freshman team also ended its season with a loss at Harlan, 37-22, to finish the season with a mark of 9-8.
The Panthers fell behind 13-2 after the first quarter, and despite improved play, couldn't dig themselves out of the hole.
"We were getting decent looks, but shot 9-of-40 from the field," freshman coach Mallory Peterson said. "That just won't win a game. We struggled to guard them inside. They got too many layups off of the lob pass."
Jenna Taylor led the team with eight points, while Camryn Somers added five and Taylor Briley scored four.
CRESTON (22) — Jenna Taylor 8, Camryn Somers 5, Taylor Briley 4, Alli Thomsen 3, Caitlin McIlravy 2. Rebounds — Taylor 8, Somers 6, Thomsen 4, McIlravy 4. Steals— Somers 3. Assists — Sydney Dunphy 2.


text:
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I could live with this one.
I could live with this one.
I love this one!
Think I prefer this one...
"Ryan Tannehill out-Brady'ed Brady"- DanPatrick
The more Nike is involved, the lower the opportunity for retro and classic. They'll start slow by necessity and then pounce, like an aspiring mass murderer who manages a good first impression when escorted home by your swooning daughter.
The dark stripes down the middle of the helmet are ghastly, with a USFL or even XFL impression. That's the last thing we need. Likewise the loud facemask.
Early '70s was our best look, IMO. The shade of aqua in those years was tremendous. I didn't really hate anything until we adopted light aqua pants, which simply look cheap. Then it got ridiculous with all orange jerseys. And the familiar desperation to look tough.
Let's see, we're content to play in a cement wasteland in an irrelevant area, the closest thing to a home/neutral site in perhaps the history of the league, with spectators practically in a different county, yet we're convinced that a fierce looking logo is the solution.
Somebody in this thread mentioned the Carolina Panthers. That's a good example. Logos really started declining in about that era, mid '90s. Carolina and Jacksonville were overdone. Jacksonville's is actually more complicated and much worse than Carolina's.
Fix the leaked logo:
I hope that is the one we keep.


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Image ID: 374241
People: Lily Kwong
Event Title: New York Academy of Art's 2012 Tribeca Ball sponsored by Van Cleef and Arpels
Location: New York Academy of Art, NYC
Photo Credits: Billy Farrell/BFAnyc.com
Copyright: BFAnyc.com
Date: Mon, Apr 16 2012


text:
abstract / theme
Abstract art uses a visual language of form, color and line to create a composition which may exist with a degree of independence from visual references in the world. Western art had been, from the Renaissance up to the middle of the 19th century, underpinned by the logic of perspective and an attempt to reproduce an illusion of visible reality. The arts of cultures other than the European had become accessible and showed alternative ways of describing visual experience to the artist. By the end of the 19th century many artists felt a need to create a new kind of art which would encompass the fundamental changes taking place in technology, science and philosophy. The sources from which individual artists drew their theoretical arguments were diverse, and reflected the social and intellectual preoccupations in all areas of Western culture at that time.
Themes represent basic categories of thought, emotion, or value. While our assignment of themes may at times seem arbitrary or whimsical, they serve to link together artists and movements along non- hierarchial pathways. Follow the themes to look for new disciplines that share qualities with those you already like, or to open up new worlds of Art and Culture.


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HP Proliant ML370 G2 1.400GHz with 512K Cache
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Overview:From remote sites to the data center the ProLiant ML370 Generation 2 is the industry's most versatile 2-way rack or tower server that is the first in its class to offer advanced memory protection and high availability features. Delivering more configuration possibilities than its predecessor the ProLiant ML370 G2 offers hot plug redundant fans 1+ 1 hot plug redundant power supplies hot plug PCI slots and multiple tool-free racking solutions. Powered by the newest Intel Pentium III processors with 512K cache up to 6GB of 2:1 interleaved 133MHz ECC SDRAM and 64-bit/66MHz PCI slots the ProLiant ML370 offers unprecedented performance levels never before seen in this class of server product. The added configuration flexibility enhanced chassis design and additional availability features have resulted in a highly versatile 2-way server product that is ideal for a myriad of business scenarios.
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I'm a Web Application Developer in Atlanta. My diverse portfolio includes small businesses, non-profits, entrepreneurs, authors, and I've also been contracted by organizations like eBay and CNN to lend a hand in their most pivotal projects. I previously worked as a front end web developer at The Weather Channel, and I currently work as a Senior Interactive Developer at SapientNitro .
I get excited about family, playing guitar, football season, old video games, and well-formatted JavaScript files.
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My primary skill set includes JavaScript, HTML5, and CSS3. I'm at an advanced level using jQuery, AngularJS, and am quick to pick up on new JS libraries and frameworks. I also have experience working with SASS/LESS, WordPress, php, JSP, AJAX techniques, and I've developed on the front end of mobile web applications.
I work according to the Agile software development methodology and have CSM and CSPO certifications. While I consider myself to be a developer first, my ancillary skills include wireframing, search engine optimization, analytics, conversion optimization, and I've also done some design work on smaller projects. I possess a strong business acumen which stems from my past experiences as an insurance agent, consultant, and public speaker. I'm a proud graduate of Auburn University.
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The following links are related to a nationally recognized video blog that I developed while working as an insurance agent in my previous career in sales/marketing.
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- March 2011: REtechSouth – Atlanta, GA
- April 2011: Profest with the Independent Insurance Agents Association – Dallas, TX


text:
Stanley Cup Final
CBS Local Sports' 2014 Stanley Cup Final Predictions
It's LA vs. NYC. It's Quick vs. Lundqvist. It's west coast vs. east coast and with that being said … let the games begin! Here are our predictions for what is sure to be an unforgettable and thrilling Cup Final.
Four Keys For Bruins In Game 4 Of Stanley Cup Final
Now, nothing in the world is more important for the Bruins than winning Game 4. Here's a look at how they can do it.
Krug Itching To Redeem Himself After Game 1 Turnover
Torey Krug is ready to make up for his costly turnover in Game 1, and it sounds like the Bruins will give him that opportunity.


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Wenger Men's Black Stainless Steel Watch
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text: News from the Heights If you need more information, call Le Moyne's Office of Communications at 315-445-4555 or contact via email Joe Della Posta or Molly McCarthy. Read past issues of the magazine Carmen Basilio, Boxing Great and Former Le Moyne Physical Education Instructor, DiesThe Le Moyne community is mourning the loss of Carmen Basilio, one of Le Moyne College's most recognizable and famous names from its past. Basilio died on Tuesday in Rochester at the age of 85. The legendary fighter, whose greatest pugilistic claim to fame was a 1957 defeat of Sugar Ray Robinson, served as a physical education instructor at Le Moyne in the 1960s and 70s. Dozens of stories and tributes to Carmen have run in the past day across the U.S., in major media outlets such as ESPN, the Chicago Sun Times, the New York Daily News, as well as more regional coverage in the Rochester Democrat & Chronicle, the Syracuse Post-Standard, and the Albany Times Union. Carmen is survived by his wife, four children, eight grandchildren and 10 great-grandchildren. posted on: 11/8/2012


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Random First Lines:An adrenaline-filled insight to the person I am in real and in my mind. » Read
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text:
The Killing Jar
A stranger armed with a shotgun takes seven patrons hostage in a remote roadside diner. But as the body count increases, the desperate survivors discover that one of the hostages may be even more dangerous than their captor.
Cast: Michael Madsen, Danny Trejo, Amber Benson, Harold Perrineau, Kevin Gage
Produced by:
Directed by: Mark Young
Written by: Mark Young
Running time: 1hr 40min
Opens: Mar 19, 2010 Limited
|Theaters for Today
Pick a day
on this day.


text:
Commemorate the glory of Asia's first Winter Olympic games! This beautiful poster, published by the IOC at the Olympic Museum in Lausanne, Switzerland, features a reprint of the official poster for the 1972 Winter Olympics, held at Sapporo on Japan's Northern island of Hokkaido. With a unique, attractive color scheme and a brilliant logo design, designer Takashi Kono produced a spectacular piece of sports art for your wall. Whether you competed in the games yourself, attended as a fan, are a citizen of the host region, or are simply a fan of the Olympic movement, this is a must for the wall of your home or office!
Product Specifications:


text:
Despite conceding there have "always been difficulties", Nico Rosberg believes Mercedes can move on from their Monaco fallout.
With Rosberg having taken pole position through a mistake that cost Lewis Hamilton the chance to fight for it, tensions were high at Mercedes on Sunday.
Speaking to the BBC prior to the grand prix, Mercedes executive director Toto Wolff revealed that Rosberg and Hamilton were "not happy to see each other" while Niki Lauda said he tried to "fix this this morning with Lewis" but that he "couldn't."
That tension carried through into Sunday's 78-lap Monaco GP with Rosberg holding the advantage throughout.
He eventually took the chequered flag 9.2s ahead of Hamilton, claiming his second victory on the streets of Monte Carlo.
The situation remained frosty in the post-race podium celebration as there was barely a handshake between the two.
But despite the current situation, Rosberg reckons it will be sorted out.
"There's always been difficulties," he revealed, "but we always sit down and discuss it and move on, and that is what we will do."
The German was also questioned about Hamilton's recent comments that he was more hungry than Rosberg.
The 2008 World Champion said his upbringing in Stevenage where he "lived on a couch in my dad's apartment" compared to Rosberg's in "Monaco with jets and hotels and boats" meant he wanted it more.
Rosberg, though, would not be drawn on the matter.
"I didn't hear Lewis say that so I am not going to comment, it is easy for you to just invent something," he told Autosport.
"Even if something like that was written, between what Lewis said and was written... I know Lewis would not say something like that, maybe to me, but not to the press."
Related Links
Rosberg Wins Monaco, Bianchi Scores
Race Day In Monte Carlo


text:
I've been noticing that when my mig gun line has a loop or coiled in it the wire feed is not constant and smooth. The gun is older and has seen lots of use. Does the group think the liner needs to be replaced or could it be something else involving the wire feed. When I say it has a coil in it, I mean the line will sometimes coil around and lay on itself when I'm welding. I don't always have the Mig gun line completely pulled straight before welding.
Results 1 to 8 of 8
Thread: Mig gun liner
06-20-2006, 04:32 PM #1Member
- Join Date
- May 2006
- Location
- Kansas City Missouri
- Posts
- 84
Mig gun liner
That would be a good place to start, it might have a small kink in it. You might want to tighten down the drive rolls a smidge also...BobBob Wright, Grandson of Tee Nee Boat Trailer Founder
Metal Master Fab Salem, Oh 44460
Birthplace of the Silver & Deming Drill
1999 MM185 w/185 Spoolgun,1986 Thunderbolt AC/DC
Spool Gun conversion. How To Do It. Below.
07-09-2006, 07:33 AM #3Junior Member
- Join Date
- Jul 2006
- Location
- Sarnia,Ontario,Canada
- Posts
- 28
One of the biggest problems with wire feed binding is dirt in the liner.
Before you go out and buy a new liner, take your current liner out and soak it in some acetone for a day then blow the liner out with compressed air. Sometimes you may have to do this a few times to get all the crud out of it.
I dont recommend this for a teflon liner as I would think the acetone might melt the teflon but for a normal coiled steel liner this works very well.
Always make sure to put the felt wiper back on the wire when changing an empty roll out.
Hope this helps you out
07-09-2006, 12:29 PM #4Senior Member
- Join Date
- Sep 2005
- Posts
- 100
I was once told to run a slightly oversize liner on Miller torches. The rep said it would not effect the feed but stopped the binding.
I don't know if this is fact or not.
07-30-2006, 06:18 PM #5Member
- Join Date
- Jul 2006
- Posts
- 89
mig liner
I think I've heard the current can swell the wire making it "sticky" in the liner. This could be bullcrap.
My own feeling is that coils, or bends make smooth feeding difficult. Have you ever tried pulling electrical wire through conduit? The radius diameter AND number of bends makes it much more difficult.
07-31-2006, 03:17 PM #6Member
- Join Date
- May 2006
- Location
- Kansas City Missouri
- Posts
- 84
I replaced the liner and the gun runs smooth and without hesitation. I didn't notice any kinks in the line, but did notice some rusty areas ???????
i agreeOriginally Posted by drewworm
FarrisGone But Never Forgotten!
07-31-2006, 08:03 PM #8Junior Member
- Join Date
- Feb 2006
- Location
- North Texas
- Posts
- 10
I just had similar problems w/ my 350P. But it also would sputter alot at starts and during the weld. I was told to pull the liner and look for kinks. If no kinks in liner then while you have it out use your luber cleaner and pour it in one end and miraculously junk came out. Also check your rollers for wear. If they are worn out and you keep tightening pressure on them your not doing anything.
Good Luck, JWOOD


text:
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Refinery 29
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[UPDATE: This story was originally published on April 24, 2012.]
It takes guts galore to work it in front of a camera, particularly as a style news anchor on live TV. You've gotta know your shizz, think on your feet, and rock a ravishing face with grace while you're at it. That's why we give mad props to E! News correspondent Catt Sadler—she's always perfectly composed and the picture of well-versed perfection (you don't win an Emmy for phoning it in!).
And once we got to know the press star, one thing became clear: None of that camera quip is an act. Catt's brimming with down-to-earth Midwestern charm and has an unabashed personality that makes you want to instantly BFF her. She's truly the whole
kit Catt and caboodle! We know you'll concur after glimpsing at her outstanding off-duty style, and reading about why there really are no airs about this on-air pro.
Photographed by Molly Cranna
Photographed by Brenna Egan; Photographed by Molly Cranna


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Squeaky Clean Polo (Men's)
In Stock Product Number: 20416
Offering T-shirt comfort with a collar, the Squeaky Clean Polo shirt is perfect for cleaning up after sunbaked beach days or a lunch-hour surf. Made from light and soft-wearing 100% organic cotton jersey in a range of stripes and solids, the Squeaky Clean features a simple 3-button placket, side vents, traditional polo collar, straight hem and single patch pocket on the chest.
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Review ProductId: 18312
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The OC12 POS line cards provide the Cisco 7304 router with single or dual 622.080-Mbps POS interfaces on a single card. You must use the appropriate optical fiber cables to connect the OC12 POS line card with an external OC-12 network.
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Gym Class Heroes Say They Are Still Underdogs And Fighters
With several hit songs under their belts it's hard to imagine that the guys in Gym Class Heroes could still feel like outsiders or underdogs. "It gives us so much freedom artistically to do what we want. It's not so bad, being an underdog," said singer Travis McCoy.


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Nuremberg: Its Lesson For Today (Nurnberg und seine Lehre) (1948)
"Nuremberg: Its Lesson For Today" shows how the four allied prosecution teams from the United States, Great Britain, France, and the Soviet Union built their case against the top Nazi leaders. As documented in the film, the trial established the "Nuremberg principles," laying the groundwork for all subsequent prosecutions, anywhere in the world, for crimes against the peace, war crimes, crimes against humanity, and genocide.
Produced by:
Directed by: Pare Lorentz, Stuart Schulberg
Written by: Budd Schulberg, Stuart Schulberg
Running time: 1hr 18min
Opens: Sep 16, 2011 Limited
|Theaters for Today
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Fans in Middle Tennessee will have yet another option to listen to Vanderbilt football games this fall. Vanderbilt athletics and ALT 98.3 WNRQ-HD2 have reached an agreement to have Commodore football games carried on the new station this fall.
Click here for the original story.
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Assistant Professor of Interaction Design
Assistant Professor of Interaction Design
Brendan Griffiths is a graphic and interaction designer living and working in New York City. He is a partner in the design practice Zut Alors! where he has collaborated with a wide variety of clients including Bloomberg View, Creative Time, The New York Times, Time Magazine, Condé Nast, Performa, Print Magazine, Socrates Sculpture Park, and Johnson & Johnson. In 2012 he was selected as one of Print Magazine's New Visual Artists and has been included in Graphic Design: Now in Production at the Walker Art Center. He holds an MFA in graphic design from Yale University.
graphic design, interaction design, typography, programming, user interface design
Creative Computing
Core Lab Interaction
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Maison Boinet
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"But history did not end in 1965."
— Chief Justice John Roberts on Tuesday
Progressives resent progress when it renders anachronistic once-valid reasons for enlarging the federal government's supervisory and coercive powers.
Hence they regret Tuesday's Supreme Court ruling that progress has rendered Section 4 of the 1965 Voting Rights Act unconstitutional.
This section stipulates the formula by which nine states and some jurisdictions in others are brought under Section 5, which requires them to get federal permission — "preclearance" — for even the most minor changes in voting procedures.
The 15th Amendment empowers Congress to enforce with "appropriate legislation" the right to vote. Sections 4 and 5 were appropriate 48 years ago, when the preclearance provisions were enacted for five years. They have been extended four times, most recently in 2006 for 25 years.
The VRA is the noblest legislation in American history, more transformative than the 1862 Homestead Act, the 1862 Morrill Act (land-grant colleges) or the 1944 GI Bill of Rights. But extraordinary laws that once were constitutional, in spite of being discordant with the nation's constitutional architecture, can become unconstitutional when facts that made the law appropriate change. The most recent data, such as registration and voting rates, on which Section 4 is based, are from 1972.
The data would have been 59 years old when the most recent extension would have expired in 2031. Tuesday's decision prevents this absurdity that Congress embraced.
In 2009, in a case in which the court chose not to rule on the continuing constitutionality of the VRA's formula, the court — Chief Justice Roberts writing for the majority — clearly challenged Congress to update the VRA because it "imposes current burdens and must be justified by current needs." On Tuesday, Roberts tersely said Section 4 is "based on decades-old data and eradicated practices."


text:
If you can dream it, you can do it. -Walt Disney
Quality is a great business plan. -John Lasseter
Let's make some funny pictures. -Tex Avery
I never considered a difference of opinion in politics, in religion, in philosophy, as cause for withdrawing from a friend. -Howard Zinn
When critics sit in judgment it is hard to tell where justice leaves off and vengeance begins. -Chuck Jones
And what do you benefit if you gain the whole world but lose your own soul? -Jesus
A man should never neglect his family for business. -Walt Disney
What's most important in animation is the emotions and the ideas being portrayed. -Ralph Bakshi
Once you have heard a strange audience burst into laughter at a film you directed, you realize what the word joy is all about. -Chuck Jones
Before enlightenment: chop wood, carry water. After enlightenment: chop wood, carry water. -Buddhist Proverb
Sign In
Animation Rep/Agent
Topics related to the business of animation.
3 posts • Page 1 of 1
Animation Rep/Agent
Hey all.
Long time off-and-on member and/or reader.
I am in LA this week, and I was looking at possibly meeting with LA animation representation / agents as opposed to meeting with ad agencies, animation studios, etc. I work out of the East Coast doing animation for advertising, some tv shows, and other entertainment/advertising things for the web (mobile games, online campaigns, webisode animation, etc.)
Anyone have any good recommendations or leads for me when it comes to animation reps?
Re: Animation Rep/Agent
FYI - many of you that have been here for many years knew me as coffeecat when I was an active poster.
I even met some people from the board several years ago at a Don Bluth Tune Up seminar in PA.
Re: Animation Rep/Agent
Hey there Eastwood / coffecat! Great to see you on the forums again!
It's very difficult to line up an agent or rep in the animation biz. They only accept referrals from clients they represent. Also they're not inclined to rep artists looking for employment. The trend for agents today is representing artists who have original content they've produced and who've experienced a level of success with it.
In other words ya gotta be somebody in animation already having made it on your own before they'll take you on as a client.
That's the latest word from a recent event involving agents/reps and managers at the Guild.
That said, Google "animation agents" and see what you can find. Here's a link that came up with a long list of agencies in entertainment in California...
One of the agencies that reps many top animation artists is the Gotham Group and they don't appear on the list. In fact they don't even have a website that takes you anywhere other than a simple homepage.
Hope this helps. Good luck!
Daily Z
3 posts • Page 1 of 1


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A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 (6)
Venezuelan Equine Encephalitis Virus is a mosquito transmitted virus effecting both humans and horses. The last major outbreak in 1995, reported an estimated 70,000 - 100,000 humans infected and a similar number of known horse infections. In humans the symptoms present as fever, headache, and encephalitis. Although the mortality rate is below 1%, the neurological disease is apparent in >/= 14% more ..
BioActive Compounds: 4
Related Experiments
Southern Research Institute (Birmingham, Alabama)
NIH Molecular Libraries Probe Production Centers Network (MLPCN)
Assay Provider: Dong Hoon Chung, University of Louisville
Award: 1 R03 MH087448-01A1
Venezuelan Equine Encephalitis Virus is a mosquito transmitted virus effecting both humans and horses. The last major outbreak in 1995, reported an estimated 70,000 - 100,000 humans infected and a similar number of known horse infections. In humans the symptoms present as fever, headache, and encephalitis. Although the mortality rate is below 1%, the neurological disease is apparent in >/= 14% of patients. There is no FDA approved vaccine or therapeutic and supportive care is limited. Thus, prophylaxis and efficacious treatments are critical to minimizing the impact of the transmissible disease on human and equines.
The US Army has been developing vaccines for VEEV as they appreciate the impact of the disease on soldiers as well as its potential use as a bioweapon. The vaccines, which are comprised of attenuated live virus, are still in the investigational new drug (IND) stage and are only available through the Special Immunization Program at United State Army Medical Research Institute of Infectious Diseases (USAMRIID) for protecting personnel working with the virus. A few other vaccine candidates are in the IND stage, such as formalized killed TC-83 vaccine and the live attenuated V3526 vaccine. Again those vaccines have not been FDA-approved due to lack of efficacy and adverse effects seen during clinical trials.
The assay provider has developed and validated a 384-well cell-based assay that measures CPE induced in Vero 76 by VEEV infection, using a luminescent-based detection system for signal endpoint. The overall goal of this project is to discover novel compounds with anti-VEEV replication efficacy and minimal cytotoxicity in vitro.
Cell Culture: Vero 76 (CRL-1587, ATCC) were purchased from ATCC and maintained in 37C incubator with 5% CO2. The cells were cultured in a complete media (Minimum Essential Media with Earle's salt and 10% fetal bovine serum). Cells were passaged once a week and harvested from flasks using 0.05% trypsin-EDTA.
Assay Media - Preparation of Complete DMEM media: 5mL Pen/Strep (Gibco, Cat. No. 15149) and 50 mL of heat-inactivated FBS (Gibco, Cat. No. 10082147 ) was added to 500mL of Dulbecco's Modified Eagle Medium (Gibco, Cat. No. 11995-073).
Virus : TC-83 strain was obtained from Dr. Brett Beitzel from United State Army Research Medical Research Institute for Infectious diseases and amplified in BHK C-21 cell line once.
Dose Response Compound Preparation: For dose response screening, compounds or carrier control (DMSO) were diluted to 3x in Complete DMEM media. Test compounds were serially diluted 1:2 resulting in an 8 point dose response dilution series. (final plate well concentration ranging from 50uM to 0.39uM and a final DMSO concentration of 0.25%). Thirty ul of each dilution was dispensed to assay plates (0.75% DMSO) in duplicate.
Control Drug: The positive control drug for this assay, mycophenolic acid was solubilized in DMSO. It was diluted and added to the assay plates as described for test compounds. Final concentration for ribavirin was 10uM. All wells contained 0.25% DMSO.
Assay Set up: Vero 76 cells were plated in 96-well plates at a density of 15,000 cells per well in a volume of 45uL of DMEM complete media. The cells were grown for 24 hours prior to testing in a 5% CO2, 37C cell culture incubator. Viruses, TC-83 strain, was diluted in cell culture medium to be 750 pfu/ 15uL (0.05 MOI) and then added to the plates at a volume of 15uL per well. The plates were incubated for 48 hours in a 37C incubator with 5% CO2 .
Endpoint Read: Following the two day incubation period, the assay plates were equilibrated to room temperature for 10 min and an equal volume (90uL) of Cell Titer-Glo reagent (Promega Inc.) was added to each well using a Microflow (Biotek,VT) and plates were incubated for an additional 10 min at room temperature. At the end of the incubation, luminescence was measured using a Synergy4 Multimode plate reader (Biotek,VT) with an integration time of 0.2 s.
Data Analysis: Results are reported as percent (%) CPE inhibition and were calculated using the following formula: % CPE inhibition = 100*(Test Cmpd - Med Virus)/(Med Cells - Med Virus). Four ribavirin positive control wells were included on each plate for quality control purposes. To quantify the viral cytopathic effect, IC50s were calculated for each substance using the 4 parameter Levenburg-Marquardt algorithm with the minimum and maximum parameters locked at 0 and 100, respectively.
Possible artifacts in this assay include, but are not limited to, compounds that interfere with the luciferase reaction, absorb luminescence, or precipitate.
Of the compounds tested, those that showed at least 30% inhibition at any tested dose were considered active.
The following tiered system has been implemented at Southern Research Institute for use with the PubChem Score. Compounds in the primary screen are scored on a scale of 0-40 based on inhibitory activity where a score of 40 corresponds to 100% inhibition. In the confirmatory dose response screen, active compounds were scored on a scale of 41-80 based on the IC50 result while compounds that did not confirm as actives were given the score of 0. A scale of 81-100 based on the IC50 of active compounds is used for purified/synthesized compounds to indicate a high level of confidence in the results. Inactive compounds are given a score of 0.
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
BAO: assay design: viability reporter:atp content
BAO: assay format: cell based format
BAO: bioassay specification: assay biosafety level: BSL2
BAO: bioassay specification: assay measurement type: endpoint assay
BAO: bioassay specification: assay stage: secondary: alternate confirmatory
BAO: detection technology: luminescence: chemiluminescence
BAO: format detail: reagent: inducer: none
BAO: meta target detail: binding reporter specification: interaction: protein:small molecule
BAO: meta target: biological process target: viral reproduction
BAO: meta target: molecular target: protein target: enzyme: transferase: kinase
BAO: version: 1.4b1090
From PubChem:
Assay Format: Cell-based
From ChEMBL:
Assay Format: Cell-based
Assay Type: Functional
Result Definitions
* Activity Concentration. ** Test Concentration.
Additional Information
Grant Number: 1 R03 MH087448-01A1
Data Table (Concise)


text:
Please check UI Extension, Kootenai County's Facebook page for the most up-to-date information while this website is under construction.
What we do
University of Idaho Extension helps citizens improve their social, economic and environmental quality of life through research-based educational programs in response to locally identified issues and needs. UI Extension, Kootenai County personnel offer programming in family and consumer science, forestry, home horticulture and 4-H youth development.
4-H Youth Development
The University of Idaho 4-H Youth Development program is a leader in guiding Idaho's youth to become responsible, productive citizens. Working and learning in partnership with caring adults, youth are empowered to reach their full potential, enhance communication skills and develop self-confidence.
Idaho Master Gardener Program
Idaho Master Gardeners expand their knowledge and skills in home horticulture and serve their communities as trained volunteers.
Panhandle Forestry
We offer workshops, field days, publications, and other practical educational programs and resources to help family forest owners, loggers, and natural resource professionals sustainably manage forests and related natural resources in Boundary, Bonner, Kootenai, and Benewah counties using current scientific research.
Food, Health and Nutrition
Family and Consumer Sciences improves the quality of life for adults, children and families through programs focused on food safety, health, hygiene and proper nutrition. Eat Smart Idaho has gained national attention for helping limited-income adults stretch their food dollars to provide healthy, low-cost, quick and tasty meals each day for their families.


text:
Ronald Reagan
Wally McNamee/Corbis
Ronald Reagan 1911 - 2004
Ronald Wilson Reagan, a former film star who became America's 40th president, was the oldest to enter the White House but radiated a youthful optimism rooted in the traditional virtues of a bygone era. To a nation battered by Vietnam, damaged by Watergate and humiliated by the taking of hostages in Iran, Ronald Reagan held out the promise of a return to greatness, the promise that America would ''stand tall'' again.
He managed to project the optimism of Franklin D. Roosevelt, the faith in small-town America of Dwight D. Eisenhower and the vigor of John F. Kennedy. In his first term he restored much of America's faith in itself and in the presidency, and he rode into his second term on the crest of a wave of popularity.
But late in 1986, halfway through his second term, Mr. Reagan and his administration were plunged into turmoil by Iran Contra. Contrary to official policy, Mr. Reagan's subordinates sold arms to Iran as ransom for hostages in Lebanon and diverted profits from the sales to the rebels fighting the Marxist Sandinistas then governing Nicaragua. A joint Congressional investigating committee reported that the affair had been ''characterized by pervasive dishonesty and secrecy'' and that Mr. Reagan bore ultimate responsibility for the wrongdoing of a ''cabal of zealots."
But until the Iran-contra affair, Mr. Reagan enjoyed tremendous popularity. He used that popularity and a consummate political skill to push many of his major programs through Congress. And despite the affair, he crowned his two terms with a nuclear arms agreement with the Soviet Union that reduced the nuclear arsenals of both countries for the first time, setting the stage for a new relationship with the Soviets under the leadership of Mikhail S. Gorbachev.Read full obituary
Highlights from the Archives
A Champion of Small Government Who Helped Reset the World Stage
When he first entered the White House in 1981, Mr. Reagan was a vigorous 69-year-old Republican who promised a new ''morning in America.'' In his first term he restored much of America's faith in itself and in the presidency, and he rode into his second term on the crest of a wave of popularity. He used that popularity and a consummate political skill to push many of his major programs through Congress.June 7, 2004 usNews
A President Who Listened
I have just sent to Nancy Reagan a letter of condolence for the passing of Ronald Reagan. The 40th president of the United States was an extraordinary man who in his long life saw moments of triumph, who had his ups and downs and experienced the happiness of true love. It so happened that his second term as president coincided with the emergence of a new Soviet leadership -- a coincidence that may seem accidental but that was in effect a prologue to momentous events in world history.June 7, 2004 opinionOp-Ed
U.S.-Soviet Tension Now Receding, Reagan Declares
In a report on his meeting with Mikhail S. Gorbachev, President Reagan said today that longstanding tensions between East and West were receding steadily as the Soviet Union makes major changes in its internal policies and structure.June 4, 1988 worldNews
Moscow Summit: Reagan Says He Was Moved By Contacts With Russians
President Reagan said today that his summit meeting with Mikhail S. Gorbachev had accomplished ''a good deal of important work'' and that he had found his contacts with the Soviet people in his four days here ''deeply moving.''June 2, 1988 worldNews
President Admits Flaws in Pursuing Secret Iran Policy
President Reagan, adopting a highly personal and apologetic tone, said today that the execution of his secret policy initiatives toward Iran was ''flawed,'' and that ''mistakes were made.'' The remarks by the President, made in his weekly radio address, marked a clear shift away from the defiant stand he had previously adopted in the face of continuing public and Congressional criticism.December 7, 1986 worldNews
The Iran Affair: A Presidency Damaged
After six years of seeming invulnerability, President Reagan has been grievously damaged by the crisis over secret arms shipments to Iran. With a unanimity rare in Washington, leading Republican and Democratic politicians agreed today that the disclosure of payments to the Nicaraguan rebels and the departure of two White House aides had probably hurt the Administration more than it helped. Some think the damage may be irreparable.November 26, 1986 worldAn Analysis
Reagan, in Berlin, Bids Soviets Work For a Safer Europe
President Reagan, bringing his arduous European trip to a dramatic close with a visit to the Berlin wall, challenged the Soviet Union today to move beyond ''the dashed hopes of the 1970's'' to ''a safer and freer Europe'' in the years ahead. ''If I had a chance, I'd like to ask the Soviet leaders one question,'' Mr. Reagan said. ''Why is that wall there? Why are they so afraid of freedom on this side of the wall?"June 12, 1982 worldNews
Ronald Reagan, Heretic
There's a gaping disconnect among Republicans in 2015 between their worship of the 40th president and the reality of his long public career.
September 4, 2015, Friday
MORE ON RONALD REAGAN AND: Reagan, Ronald Wilson , Republican Party , Trump, Donald J
The Neverending Fight to Save Social Security
Republicans' latest plan for unnecessary cuts to Social Security involves the disability fund.
September 1, 2015, Tuesday
MORE ON RONALD REAGAN AND: Reagan, Ronald Wilson , United States , House of Representatives , Republican Party , Senate , Disability Insurance , Pensions and Retirement Plans , Retirement , Social Security (US) , United States Politics and Government
Scott Walker Shows His 'Aggressive' Side
Gov. Scott Walker of Wisconsin called himself "aggressively normal" in the first Republican presidential debate — and saw his poll numbers go backward. Now he's highlighting the "aggressive" part.
September 1, 2015, Tuesday
MORE ON RONALD REAGAN AND: Reagan, Ronald Wilson , Walker, Scott K , Republican Party , Presidential Election of 2016
As His Term Wanes, Obama Champions Workers' Rights
The administration has tried to get back protections for workers eroded by conservative activism and changes in the economy over 40 years.
September 1, 2015, Tuesday
MORE ON RONALD REAGAN AND: Labor and Jobs , Labor Department (US) , National Labor Relations Board , Reagan, Ronald Wilson , Overtime , Obama, Barack , Freelancing, Self-Employment and Independent Contracting , Entrepreneurship , Wages and Salaries , Minimum Wage , Regulation and Deregulation of Industry , Organized Labor , Income Inequality
Ronald Reagan Receives a New Term, on TV
The former president is appearing on a host of shows, from "Narcos" to "Wet Hot American Summer: First Day of Camp."
August 30, 2015, Sunday
MORE ON RONALD REAGAN AND: Television , Reagan, Ronald Wilson , Campbell, Bruce , Narcos (TV Program)
Donald Trump Steals the Show, Mixing Politics and Pizazz
From the opening moments, when he flashed a grin and a victory sign at the crowd, Mr. Trump remained his irrepressible self: aggrandizing, unapologetic and cutting.
August 7, 2015, Friday
MORE ON RONALD REAGAN AND: Presidential Election of 2016 , Trump, Donald J , Debates (Political) , Primaries and Caucuses , Kelly, Megyn , Republican Party , Fox News Channel , Cleveland (Ohio) , Clinton, Hillary Rodham , Reagan, Ronald Wilson
My Question for the Republican Presidential Debate
I'd certainly pay a nickel for the candidates' thoughts.
August 5, 2015, Wednesday
MORE ON RONALD REAGAN AND: Gasoline Tax (US) , Infrastructure (Public Works) , Highway Trust Fund , Debates (Political) , Presidential Election of 2016 , Reagan, Ronald Wilson , Republican Party , House of Representatives , United States Politics and Government , Senate
Richard S. Schweiker, Former Senator and Reagan Confidant, Dies at 89
Mr. Schweiker, a Pennsylvania Republican, served for two decades in Congress and two more years in the White House in an era of assassinations, war and sweeping social changes.
August 4, 2015, Tuesday
MORE ON RONALD REAGAN AND: Deaths (Obituaries) , United States Politics and Government , Reagan, Ronald Wilson , House of Representatives , Pennsylvania , Health and Human Services Department , Senate , Schweiker, Richard S (1926-2015)
Calling for a Conservative Heart at the Core of America
Arthur Brooks, the president of the American Enterprise Institute, emphasizes a more people-centric, optimistic approach to conservatism.
July 27, 2015, Monday
MORE ON RONALD REAGAN AND: Brooks, Arthur C , American Enterprise Institute for Public Policy Research , Conservatism (US Politics) , Republican Party , Washington (DC) , Poverty , Johnson, Lyndon Baines , Reagan, Ronald Wilson
We Need Optimists
Leaders have to stop choosing pessimism and try to inspire hope.
July 26, 2015, Sunday
MORE ON RONALD REAGAN AND: Presidential Election of 2016 , United States Politics and Government , Optimism , Reagan, Ronald Wilson , Republican Party
Walker Speaks on Admiration for Reagan
Gov. Scott Walker of Wisconsin, a Republican, talked about Ronald Reagan on Feb. 6 at Eureka College in Illinois, where President Reagan studied.
Limits on Presidents Acting Alone
How a handful of presidential actions have been challenged in court, by Congress and by later presidents.
Something Stately, Preferably in Black
As the Secret Service shops for a new presidential limousine, here is a look at some past models.
Think Back: Obama's Cold War
In addressing crises in Ukraine, Syria and elsewhere, President Obama seems to be drawing on the memory of old-time superpower struggles, says Sam Tanenhaus.
Think Back: The Military Budget
United States military spending has ballooned since World War II, although Americans have historically been reluctant to go to war. The Times's Sam Tanenhaus explains why.
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We are here to serve you! Below is a list of resources we hope you will find useful in your spiritual life and ministry. From books to brochures to our statement of beliefs, this is where you will find some of our most popular resources. Sort by clicking the categories on the left to find what you need quickly and easily.
Leadership Book Review
Code of conduct.
Endorsement criteria to serve as a military chaplain from the NAB
Guidelines on acceptance as an NAB military chaplain.
Covenant and Code of Ethics for Chaplains in the Armed Forces
Scholarship established by the North American Baptist Conference to assist fulltime students from NAB churches to prepare for vocational ministry.
Revised 2012
NAB directory listings for churches, international office staff, military chaplains, cooperating organizations, general council, nursing and senior homes, youth contact, and camps.
Frequently Asked Questions regarding the new NAB Healthcare for US.
Overview of the Natural Church Development (NCD) process, benefits, and cost.
News, Stories, and Updates from the NAB family
GMI recently published the new Operation World personal CD-ROM, professional DVD-ROM and wall map.
The North American Baptist Conference sponsors a conference-wide retirement program specifically designed for pastors and staff employed by NAB churches.
The North American Baptist Conference sponsors a conference-wide retirement program specifically designed for pastors and staff employed by NAB churches.
Connecting Retired Christian Workers and Friends of the NAB Conference...this newsletter is published three times a year.
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Updated July 2012
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In an exciting victory for animals and advocates in the Lone Star State, Texas legislators have passed a law prohibiting the use of gas chambers to euthanize animals. Sponsored by Senator Kirk Watson, this new law, which became effective immediately upon Governor Rick Perry's signature on May 10, will also protect shelter workers from dangerous exposure to carbon monoxide.
The ASPCA partnered with the Texas Humane Legislation Network to help ensure this critical legislation passed during the current session. The new law makes sodium pentobarbital injection, also referred to as euthanasia by injection (EBI), the state's only approved method of euthanasia. Euthanasia by injection takes effect faster, acts more reliably and causes less pain and trauma than gas.
In situations where euthanasia must be administered, it should be done with compassion and care, which gas chambers do not provide. We applaud Governor Perry and Senator Watson, as well as all of our Texas Advocates, for taking this important step for animals.
Inspired by this big win in Texas? Be sure to join the ASPCA Advocacy Brigade so you can take action on current animal-related bills!