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This conversation is closed.
Is imagination a more valuable asset than knowledge?
I think imagination a more valuable asset than knowledge.
Imagination has limitless value, while knowledge is limited
Kepu Li
Nov 7 2013: I agree; however, to produce a result, only imagination is not enough. Admittedly, Imagination might be a more valuable asset for a person because it's a person's characteristic, while knowledge is something can be learned for other sources. However, knowledge is the foundation for a person to make his imagination become realistic, Imagination, itself, might be too ideal and fancy without the foundation of knowledge. And how to define valuable is also a issue. Is it something rare or something meaningful? Whichever meaning can cause different perspectives. So, for now, I think imagination and knowledge are linked together and are both valuable asset for a person.
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Nov 7 2013: I am totally aprove with you. As i mentioned in my comment, both of them are important because there are interdependent. You pointed out if the imagination without the foundation of knowledge, it might be too fancy and ideal. That is so true! We can always make the knowledge become limitless vaule as a result of the awesome imagination!
Kepu Li
Nov 7 2013: Yes, it is. But I'm still wondering what does he mean "valuable".Nov 7 2013: You raise an excellent point. To succeed in modern day society, you need both working hand in hand.Nov 7 2013: I strongly agree with you because knowledge is the basis to use our imagination as a practical tool to enhance our lives. Imagination becomes realistic and an important source to inspire us to acquire knowledge.
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Melody Guan
Nov 7 2013: There is no denying that imagination and knowledge oth play a cruvial role in human' s life. They are interrelated and interdependent, because without each of them individuals have no ability to acquire a coloful and interesting life.
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It is imagination that provides a colorful world for humans. In essence, imagination is the part and parcel of inventation. Scientists take advantage of their rich imagination to conceive a new thing and then combine it with their knowledge to realize it. In this way, both imagination and knowledge are important elements to acquire the achievement.
However, leaders in different fields are supposed to pay more attention to imagination or knowledge. For example, in terms of fictionists or designe, it is no exaggeration to say that imagination is their life. Without doubt, imagination is the source of their originality and inspiration. But to teachers, they shoud be mindly of their knowledge. Teachers ought to gain more and more knowledge and use them to foster their students.
Apart from that, the importance of imagination and knowledge is equal to children. Nowadays, due to the education a large number of children's imagination is limited, parents and teachers are well advised to make efforts to balance imagination and knowledge.
Barbara C.A
Nov 7 2013: Imagination and knowledge are extremely connect. Without imagination we can`t reach knowledge, because imagination is the predecessor of knowlege.
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When you try to solve a problem first you imagine the possible causes for it happen, and after you try to fix some of this causes to see what is realing happening. When you figure out a solution you acquire knowledge for this problem. When an apple felt on Isaac Newton`s head, before the idea of gravity and the knowledge that it brings to our life, he needed to imagine possible explanation for it. And after this knowledge other people could think more about the world and imagine diferents things leading to a new concept or knowledge. So it is really hard to separate imagination from knowledge.
Although, the creativity imagination is dying because of the extremely importance some people give to scientific knowledge without seeing the connection to imagination. This people need to see the relation between it, to improve their thoughts and also estimulate their minds to reach a new solution for a problem. Both are extremelly important, so one shouldn`t be consider more important than other.
Nov 7 2013: Very convincing!Nov 7 2013: I totally I agree with you...Nov 7 2013: Imagination is not more valuable than knowledge; they are both extremally important and complementaries. The ability to imagine allows us to generate knowledge that is part of the foundation responsible for inspiring someone's imagination in order to produce more knowledge. It's a cycle that when working aproprietely, enhance the human being's capabilities. Imagination and knowledge should not be seen separately. For instance, the previous scientists such us Isaac Newton used his imagination to create some important concepts that generated crucial knowledge and this knowledge inspired people use imagination to create more concepts and the cycle continues.
Nov 7 2013: The more I read, the more I see that they are indeed complementary and of equal importance.Nov 7 2013: I totally agree with you, it is really impossible live without one of this. Imagination leads to knowledge, and knowledge leads to imagination. They are extremely connected. Good point! ;)
mengyang xu
Nov 7 2013: Imagination and knowledge are both very valuable assets. They make humans clever and strong, and they make humans the most powerful species from the long history. without imagination, we can not get useful and smart knowledge. without knowledge we can not practise our imagination. compare two of them, imagination is more valuable. It is imagination which can make humans differ from other species, and make people differ from each other. Everyone can get knowledge from books, while not everyone can have a great imagination. The society we live is very competitive and most of us all have enough knowledge to compete with others, and companies are now more willing to hire someone with great imagination.
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I do think knowledge is very valuable and basic to all of us. but I think imagination is more praiseworthy.
Nov 7 2013: I'm with you on this one. ;)Nov 7 2013: Without imagination, we are nothing.Nov 7 2013: I have to agree that companies are willing people with great imagination, because they need someone to develop a new solution, and bring knowledge for them. Good point. :)Nov 7 2013: I can't agree more! Imagination can make a big difference to the word that's why we really need to always keep our imagination alive! But that's hard right?
Nov 7 2013: I agree with you. If one only has knowledge, the life won't be colorful. Since imagination is the very begining of acquiring knowledge, without it, people won't be eager to get new informations.
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Also, imagination is one of the most important factors in one's life: people were born in the way of using imagination; children learn it by themselves; everyone has imagination. It is a priceless treasure, the question is how to use it effectively.
Nov 7 2013: Indeed! Effectiveness is key!Nov 7 2013: I agree. Imagination is the beginning, is what moves us forward to try put in practice new ideas.Nov 7 2013: This is a wonderful conversation and I appreciate all of the insights listed below. I think, for a period of time in my life, I lost my imagination and became acclimatized to academia and a certain framework of thinking. It was a very bleak time in my life, where things were mundane and repetitive. I have always considered myself an educated person, but the loss of my imagination stunted my personal and social growth. Fast forward a few years, and I find imagination through doing what I love, and after discovering that education is not the be all and end all. Today, I find creative thought in running, taking language lessons, dancing and writing. My greatest love of all, my two delightful children, have stimulated my memory of what an imaginative life is like. It begins with making tents and forts, playing make-believe, creating new words, forging stories and entertaining our ideas through dress up. I see through them how we likely all began; we were all little people full of brilliant ideas that were slowly stamped out as we passed through the education system. I believe in education, but never at the cost of imagination. For me, all good things in my life have started with my imagination. It began with how I imagined these things and how I imagined them materializing. It took some knowledge to get to where I am today, and to that end, I believe that the two characteristics, knowledge and imagination, go hand in hand. That said, personally, I'd take imagination any day over knowledge.
Nov 7 2013: You are such a blessed person and what a nice testimonial! It is really amazing that you could manage to revive your imagination and find happiness in simple things in life. As I said before, ignorance is bliss... in some way, acquiring knowledge is "absorbing information" and i guess that you achieved a level where absorbing information is not fun or enough anymore. Nowadays, what are they doing is "brain washing" people, they just throw us a bunch of information; but the teachers' real role is to help students learn how to think, to develop and use our innate imagination!Nov 7 2013: Your opinions really make me to think.
Nik Cronin
Nov 5 2013: Maybe they are two points on the same curve.
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Imagination and reasoning allow us to generate knowledge which enhances our imagination and reasoning, allowing us to generate more knowledge. We seem very good at it, as a species, with this recent brain mutation we've picked up. Less good perhaps at generating the wisdom needed to survive it; but you can't have everything, yet.
So maybe our imagination and reasoning are still as limited as our knowledge and what really has limitless value is wisdom.Nov 5 2013: I think all of these points are valid. My two cents has to do with using both knowledge and imagination in tandum in order to evolve as a human being. If it is to make soemthing more effecient, or to shed light on an unanswered question, using them side by side lets us move past barriors of ignorance in our faith, sciences, and even who we choose to be. Having the ablitly to imagine something better, or different, and then the knowledge to at least start to journey in accomplishing it is how we got this far. Thats my rambling session for the day.Nov 5 2013: Knowledge is the Federal Bank. Imagination is the market. One is complimentary to the other.
Fritzie -
Nov 5 2013: Why must we "compete" two useful attributes against each other that are most naturally used together in creative work and the creative life?Nov 12 2013: Imagination creates new ideas or things.
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Knowledge comes from our family traditions and parents information shared in childhood. Then come the books, university and what you learn in your life.
Action and Spirited positive Drive to execute what you want or what you imagined, is what really makes a difference and a change in your world.
Imagination+Knowledge+Research+TeamWork+ Action = Change Factor
Let´s start using imagination to change the world for the better.
Thanks,Nov 12 2013: It is not; one or the other. Imagination is the foundation for everything else...most importantly, knowledge. Even pain must be imagined before it is realized. Imagination IS what we are, our actions only express what the imagination already knew.Nov 11 2013: Imagination, knowledge, with a little innovation is best. Having just imagination or just knowledge can not work. If you knew everything but had no imagination you couldn't envision how things would be if you tried to use that knowledge creatively.Nov 10 2013: Imagination and knowledge are ok, but the key is hard work. You can have an idea but you need to temper it with the knowledge on how to do it in a practical manner. Many ideas that sound great, do not work in the lab. Many ideas that work in the lab can not be made practical to be used. Does that mean we stop? no, you just find the 10000 things that do not work to find the one that does.Nov 7 2013: It is generaly accepted that imagination is creating new technology. In my opinion, imagination and knowledge are similar in valuable properties. Both are impotant in laps and schools.
many of theoris start from strange imagination question. forexample, could we travel to space, can we comminicate without travlling. After strong believe to achive the dream which is comes from certine imagination thought, the scientisits work hard by using equations and formulas to end up with surpising equipments that makes our life easer and enjoyable. If they don't have enough back ground, of course they will not complete any imagination thought project. As a result, acquaintance can be learned in school or even on your own and then you can applied the information to improve our invironment.
knowledge and fiction work together in many things, such as phones, airplanes, cars, ..ect. Recently, many developed countries encourage their pubic to learn and creat a new product, hence they can be most interisting people and country.
Nov 10 2013: As Edison said, "1% inspiration, 99% perspiration". Imagination does not create technology - hard work doesNov 7 2013: Dear TED Community - just so you know, we are a class of EAP students at UBC who are studying advanced reading and writing at present. This is an amazing class who sometimes has their creativity stifled as we practice academic reading and writing on a daily basis. Hence, this question was a great one for them to answer! All 15 students contributed below as a "real life" reading and writing activity today. This is their first foray writing publicly in an online forum. Just wanted you to be aware - thank you so much for allowing us to be part of this conversation and learning experience!
Janelle Sheen - TeacherNov 7 2013: I believe imagination is more valuable than knowledge because every single person can get knowledge from studying or being taught from others, but no one can have the same imagination as others. However, I think imagination and knowledge are related to each other. If we do not have any knowledge, we cannot imagine anything. When we imagine, we are unconsciously being affected by our knowledge.
Knowledge is the foundation of imagination and imagination inspires us to get necessary knowledge. Thus, we need both knowledge and imagination; we cannot lose the one of them.
Nov 7 2013: They do go hand in hand!Nov 7 2013: I agree with you, imaginationation has limitless value! However it seems that knowledge can always benifits us more in real life. I believe that's why people tend to pay more attention to the development of knowledge, rather than imagination. Schools need to try their best to stimulate and protect children's imagination and we also need to keep our imagination from lossing them through dull daily life! Unfortunately, I believe I have lost much of my imagination and I am still losing them!
mengyang xu
Nov 7 2013: shuyan I agree with you that you are losing the imagination because i am losing it either. We need imaginationation but we also need marks to come to ubc. imaginationation seems not have much to do with our exams and major.
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Kepu Li
Nov 7 2013: I think what you guys need is not imagination yet, it is a passion of acknowledging.
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Nov 7 2013: You too.Nov 7 2013: I absolutely agree - keep your imagination alive - it is hard to restimulate when it disappears!Nov 7 2013: I am losing my imagination too! Sometimes people may focus on marks more.Nov 7 2013: I think it is. Imagination is what engages our brain to work seeking for achievements and this seeking returns to us knowledge. Imagination is the first step for new ideas and innovations and without it we are empty. If we don't have any new idea in our mind we won't try anything above our knowledge; go over our knowledge is what makes us learn more.
Nov 7 2013: In terms of forward momentum and societal progress, you make a great point.Nov 7 2013: Yes, I totally agree with you. Go over our knowledge is what makes us learn more!!!Nov 7 2013: Some say ignorance is bliss; dreamers (i.e.: with imagination) and knowledgeable people can think outside of the box, but in a different way. Knowledge allows you to question simple things in life, such as "why does the sugar melts when heated but it doesn't happen with salt?" or even the complex ones that make people want to fight against "the system"... and all this questions can be answered and solved to improve human's life, if you carry the right knowledge. Imagination also leads us to the same path, to want to discover and answer questions, but more than that, it is what allows us to use our knowledge. So, imagination is definetely a more valuable asset than knowledge, if you lack imagination your knowledge will be stucked inside you.
Nov 7 2013: Good point. Knowledge is no good if it isn't shared in some context!Nov 7 2013: I think both of them are important. It depends on different situations. Without knowledge, imagination will not be developed, and it's so hard to imagine a world lack of knowledge. Without imagination, how can knowledge be advanced and substantial?
Different jobs have their own demands. Both of them can be valuable if they are in right position.
Nov 7 2013: You make a good point. Both are very useful both independently, and codependently.Nov 7 2013: I totally agree with you. Both are really essential for us and we cannot lose both of them.Nov 7 2013: Both of them are important and equal. As imagination helps people being creatived and kowledage lead the direction of great imagination. You may say knowledge is limited, but it connects to the imagination somehow. Maybe not all but still. Like lots of great men in the history of science, they had great imagination that it had changed the world. However, do not forget most of them are standing on the shoulders of the giant-the ideas or rules have been proved. It helped them went through longer with both knowledge and imagination. Yeah, both of them are important!
Nov 7 2013: I see the link between them both. Excellent point that most scientific progress has begun with the imagination!Nov 7 2013: One would believe that both points are essential and hard to determine which is more valuable. Knowledge is the basis of creativity. Everything we created is based on the knowledge we learned. The world exposes fundamental knowlege so that we can create on this. For example, all gousts, vampires and zombies have human's figure. On the other hand, with out creation, this world would be so uninteresting and the world will stop developing. All important inventions including light bulb and computers are achivement of creation. All stunning rules including gravity and heliocentric theory are based on creation. In conclusion I think both are extremely essential.
Nov 7 2013: Is knowledge the basis of creativity? I thought creativity is sometimes completely independent of knowledge; however, I see your point!Nov 7 2013: I think imagination is the basic of creativity but sometimes knowledge is the basic of imagination. Because imagination is the source of inspiration and originality. Knowledge enables your imagination to become more widely. However, I agree with you opinion that the importances of imagination and knowledge is equal.
W. Ying
Nov 7 2013: 。
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Imagination makes our great brain.Nov 6 2013: Imagination is a precursor of knowledge. Without imagination It will be difficult or even impossible to advance our knowledge.
But I don't think it's an "either - or". Both are important.Nov 6 2013: "Imagination is more important than knowledge"- Einstein
I'll for one believe he is right.Nov 6 2013: One can't work without the other. They are both of equal value. If one of them were to be taken out of the equation, intellectual progress would be impossible.
However, in this current age of reason we revere knowledge far too much at the cost of imagination, which makes imagination feel more valuable to those who have it. The two seem to want to distinguish themselves out into separatist, destructive belief systems.
If knowledge was able to work closely with, and have respect for, imagination - then knowledge also would be limitless and as far-reaching as that imagination will allow. Metaphor, metaphysics, art and mythology (all products of the imagination) are the seeds of knowledge.
Knowledge could have limitless value if logic can live with imagination and all that it brings. At the moment it can't (because of institutionalised biases in education for example) - or won't (because of entrenched beliefs).Nov 6 2013: Perhaps.....
As Singularity comes into a fuller manifestation in society, your ability to accumulate and access Knowledge will be less valued and less needed for what is now at your fingertips on your smartphone will one day be integrated with the brain. YOUR IMAGINATION will be greatly enhanced by EXTRAPOLATIVE POWER OF THE COMPUTER. But, being human, we tend to seek external security for ourselves........thus, there will be an inevitable FIGHT between Imagination & Extrapolation. There will exist the same tension that already resides within us.....
Still, we cram knowledge into children's brains.Nov 6 2013: I think that both of them has it own value and both of them are very important. But I also think that imagination can be more wider and sure (for possibilities of realization) if you have enough knowledge.
Plenty of people has wide open mind and imagination, and they got stuck, because their ignorance made them to.Nov 6 2013: Knowledge starts with curiosity and curiosity drives imagination as well.Nov 6 2013: In what situation and at what levelNov 5 2013: Depends on the job at hand. Some things favor knowledge more, others creativity.
Some require both to an extent one is useless without the other.
Answer me this, when you go into surgery, do you prefer an entirely unimaginative doctor that knows everything there is to know about this type of medicine, or a very imaginative man that knows nothing?Nov 5 2013: Imagination can become asset if Something practical comes out of it, While Knowledge is Asset as well as liability if not use in proper manner, at right place and right time.


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While the future of The Civil Wars remains cloudy, fans will hear new (or previously unreleased) music from the Nashville/Alabama folk-pop duo later this month.
The pair collaborated with producer T Bone Burnett on the 14-track soundtrack to the upcoming film "A Place at the Table," which will be released on February 26 via Sensibility Music.The full-length documentary centers on America's hunger crisis and hits theaters and the digital marketplace on March 1.
In a release, the duo's Nashville half, Joy Williams, said the film "opened my eyes to an epidemic that is happening in our country right now—underneath many of our noses."
"It's happening to our neighbors, to our friends, to children. It's a silent battle that can be won, if we as a nation set our minds to ending it. Linking arms with T Bone Burnett to create music for such a timely and important film as this was an honor."
Williams and bandmate John Paul White announced in November that they were "unable to continue as a touring entity," citing "internal discord and irreconcilable differences of ambition," but they shared a stage briefly on Sunday to accept a Grammy for the song "Safe and Sound" with Taylor Swift and Burnett.
The album's first single "Long Time Gone" is streaming online now - head to YouTube to listen.

subset: commoncrawl


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by Mary A. Fischer, AARP The Magazine, November 2011 issue
Washington, D.C.
Speech Pathologist
"Turning 50 was quite a shock for me. I come from a family that believes in seeking the fountain of youth, and I'm not old yet! So I tried a little Botox around the forehead and a little Restylane around the smile zone. When I looked in the mirror, I thought, 'Okay, I've got a few more years of being 49.' It's something I'd do again. I want to carry a comfortable presence about myself, and if that means a little embellishment, it's fine."
Ben Baker
Chicago, Illinois
School Social Worker
"My philosophy is that beauty comes from within. In my field, I've worked with a lot of people who are gorgeous on the outside but their self-image is so poor. I have a good self-image — I'm a good person and respected in my field, so all that makes me feel good. I'm feeling okay about turning 53. I don't know if I'd ever get [plastic] surgery. Maybe 10 years from now. I'm not against it, but right now it's not a priority."
Ben Baker
Los Angeles, California
"The only thing that scares me a little about aging is general physical decline. To that end, I work out. I'm an avid runner. I started in my mid-20s, and it stuck. I love to run outside in the sun, and maybe in a few years I'm going to get really wrinkled — but that's not going to keep me from running. I think my ego boost comes from knowing that there aren't too many people my age who can run 10 miles and not die the next day! But I don't get off being the center of attention unless I'm doing a drum solo. Making music, that's my passion."
Ben Baker
Annapolis, Maryland
Yacht-insurance Agent
"I should have been dead, like, 10 times. When I was 16, I was in a car that flipped. And I was struck by lightning in 1997 — I was on the bridge of a yacht. I saw a flash, and I was gone. Then there was the sound of static and my stepson, Ian, yelling, 'Daddy's dead!' I came flying back to the present. My eyes and ears were hemorrhaging. I have to have my ears rebuilt. Now, when I look at my face and my body, all these wrinkles and scars tell stories. I've never been into doing anything to make myself look better. I know who I am. I've made it this far, and that's pretty great."
Ben Baker
Las Vegas, Nevada
Small-business Owner
"People think that if you're big, you don't have discipline. I definitely have discipline. I once went on a medically supervised liquid fast for a whole year. I'm a size 24. My family has always been this way; I can't change it unless I have surgery. I've become something of a fat activist. I eat a healthy diet and move and don't let things hold me up because I may appear to someone else an unacceptable. I believe I'm a beautiful person."
Ben Baker
Los Angeles, California
"I feel at peace with my looks. Doing the work I do has helped me get comfortable with how I am. Also, as a gay man who grew up in the era of AIDS, I'm glad to have reached the age I have, and look forward to growing older. I saw so many friends and acquaintances cut down in their prime. My sister just turned 63, and she was regretful about it, but for me it's like, 'C'mon, I'm glad you're alive — you should be glad you are alive, too.'"
Ben Baker
Anthony, New Mexico
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"Two weeks after I had my son, I turned 41. Two years later, we adopted our daughter from China, and I stopped coloring my hair. The first time I saw the gray, I thought, 'Oh, this is really different.' But my husband encouraged me every step of the way. I would get stopped with my little ones, and people would say, 'Are those your grandkids?' But simplicity has become very important to me. I just want to be healthy for my kids and set a good example. I don't want to be fixated on outside appearance."
Ben Baker
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Kosher Salads & Salad Dressings
|Roasted Beet Salad with Orange, Mint and Lime
by Ronnie Fein, KitchenVignettes.com
Beets are so sweet I like to make them all sorts of ways for the Jewish holidays, along with the traditional apples and honey we always have at our house. This recipe is incredibly easy and I make it a day in advance so that the flavors blend nicely. My Break-the-fast is always a vegetarian, dairy buffet and beet salad adds color along with the other dishes I serve.
3 large beets
Trim the beets, cutting away the greens, if any, and discarding any hard, fibrous parts of the stem. Wash and drain the greens and use them for other purposes. Scrub the beets, wrap them in aluminum foil and roast for 50-60 minutes or until they are tender.
Peel the beets when they are cool enough to handle. Cut the beets into bite size pieces and place in a bowl. Add the vegetable oil, lime juice, wine vinegar, mint and orange peel and toss to distribute the ingredients evenly. Season to taste with salt and pepper.
Let rest for 10-15 minutes before serving.
Yield: Makes 6 servings
Recipes: Salads, Beets, Parve, Kosher


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Hang tight!
Recipe by Kitty
"Light, lemony pie. Perfect for spring!"
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1 (9 inch)
unbaked pie crust
3 tablespoons
butter, softened
1 1/4 cups
white sugar
egg yolks, beaten
3 tablespoons
all-purpose flour
1 pinch
1 1/4 cups
2 tablespoons
grated lemon zest
1/3 cup
lemon juice
egg whites
Wow! This is excellent. Didn't know what to expect, but I wanted something lemony that wasn't Lemon Meringue, and this was perfect. Followed the recipe exactly, except I used a reduced fat pre-made graham cracker crust. With this substitute, the pie was practically guilt-free, and certainly worth every bite--YUM! Between three people, the pie was gone in less than 40 minutes! The pie crust wasn't a deep dish, so I had some filling left over--baked it in ramekins along w/ the pie in the same oven and for the same amount of time. UPDATE: Made this last night, only used 1 c. of sugar, and increased the lemon juice to 1/2 c.--I LOVE lemon, and this small change made it healthier and even tastier too! You can also make this with no crust, in a pie plate w/ some no-stick spray, or in little individual ramekins...the baking time and temp. is still the same. Without the crust, it's less than 150 calories per serving and has only 2 grams of fat, but still has a deliciously decadent taste:)
This didn't really turn out for me, but I think I know how I can fix it so it does. The sponge part was mostly good, but the bottom part was runny like other users had mentioned. I don't know that more time in the oven would have helped, because I had it in for another 10 minutes and I was about to burn the top part. The crust, since it was not previously baked, never cooked on the bottom. I am thinking if I would have baked the pie crust for about ten minutes and then poured the lemon mixture in, it would have helped the crust as well as finish baking the rest of the lemon stuff as well. Something that I will try next time.
65 Ratings
This is the BEST pie recipe. I've been meaning to make a lemon sponge pie ever since I first tried one at a Pennsylvanian Dutch restaurant. The one there was heavenly, and this one is just as good.
I haven't made a lot of pies, but this recipe is simple and produces great results. I made it for Thanksgiving and everyone raved about it. I even had to make another one the day after because of the demand. The pie comes out spongy on top and custardy on bottom and VERY lemony. A must for the holidays or any occasion. I used a standard pie pan (9")but I had a lot of leftover filling, so for my second pie I used a larger, deep dish pie pan (10" with a 2" depth) which was just right.
This is a wonderful recipe. The low temperature at which it bakes makes all the difference in the world. No worry about it getting too dark, and yet the filling sets beautifully. The results are superb.
This was a hit with friends that I served it too. I topped it with strawberries (macertated with lots of grand marnier) when I served it. The only problem was beating the egg whites took FOREVER but when I googled afterwards to find why it had taken so long, I read that you should not use fresh eggs (which I did)--a few days old are better for egg white beating and that you should also bring the egg whites to room temperature before beating.
I joined this site so that I could review this recipe! I made it a month ago to take to a potluck supper, where it got rave reviews. So I decided to make it again and enter it in a heritage pie contest. It won third place! Thank you, Kitty. This is a wonderfully refreshing pie - a real change from lemon meringue.
This is very good, and very easy to make. Be aware, though, that it does make alot of filling. I used a 10 inch deep dish pie plate, and still had a bit too much. I managed to get it all in, but it overflowed a bit. Normally that wouldn't be a problem, but even the little bit of smoke my oven produced managed to sink into the top 1/4 inch of the pie. lemon sponge pie should never have a smokey flavor. I took off the top little bit and it was then fabulous. I'll just put a little less in next time,and voila fab pie.
Ever find a recipe that just made you giggle it turned out so well? This one did it for me. Looking for some sort of dessert and found that I had all the ingredients on hand to make this one. I added a photo of it straight out of the oven and another when DH cut into it before it had completely cooled. It was barely warm. The consistency is that of a sponge/custard pie. Very pleasing on the palate and the lemon flavor was just right. All I did was follow instructions...and smile... a lot!!
* Percent Daily Values are based on a 2,000 calorie diet.
Lemon Sponge Pie I
Serving Size: 1/8 of a recipe
Servings Per Recipe: 8
Amount Per Serving
Calories: 340
Calories from Fat: 133
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After Life (Maro Charitra)
"Maro Charitra" is a modern day interpretation and remake of the classic movie from the late '70s of the same name. The film deals with the concept of how love transcends across all barriers.
Cast: Varun Sandesh, Anita Galler
Produced by:
Directed by: Ravi Yadav
Written by:
Running time: 2hr 18min
Opens: Mar 24, 2010 Limited
|Theaters for Today
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Comments On Jun 18, 2015:It took two to make one by the third ride. The kit is less than ideal. The rubber grommet must have hooked a branch and was lost forever as we found the flag lying on the ground. After losing one set screw I ensured the other flag's screws were extremely tight but they also were lost and the flag came apart. I have one flag remaining with all pieces gorilla glued together. I'd pay more for a one piece that is a bit more durable. Ensure the grommets allow for slippage room and just glue the thing together to save the trouble.
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Comments On Nov 23, 2014:I bought several of these. They worked fine and were cheap. Tip: Install the mounting bracket the right way, with the beveled side up. A couple of trips to the dunes and they did the job.
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Comments On May 11, 2014:Pole seems to be working just great. I like the two piece pole, however, it's a pain to always locate the allen wrench to tighten the screws holding the poles together. I'd recommend using thumb screws. It would be so much easier and quicker. I'm going to replace the screws asap!
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Comments On Apr 29, 2014:This is my first purchase for an atv flag. I installed this flag on a 1/4" springy holder and bolted it to my 1985 Honda ATC 350X. I was afraid after reading alot about these flags that it would brake, fall out or get lost. None of that happened yet. This whole setup has been through hell and back. The only thing that happened was the rubber top that keeps the flag from slipping off the top of the pole came off while flying (45 mph +) through the trees and briar bushes in the woods. So I put the flag back on and took some duct tape and cut a strip in half long ways and then wrapped it around the top of the pole about 10 times. Now that flag aint never come'n off baby!!!! I'm buying two more for my other trikes now!!!
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Comments On Dec 27, 2013:Flag is extremely well made and very sturdy. Easy install and great product for the money.
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Comments On Mar 01, 2013:good
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Comments On Oct 18, 2012:Nice Product fit great.
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Comments On Jun 04, 2012:The other Tusk products I ordered were stellar so I took a chance on this one. I made it through about a half day before it broke the first time. No biggie, I just took the broken 1 inch off the bottom and re-inserted in the bolt. Did this two more times in two days before loosing the flag completely while jumping sand dunes. I will go to a more robust solution with some sort of spring the next time.
Would work fine for less aggressive driving I suppose. Kids 4 wheelers, etc.
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Comments On Apr 23, 2012:Me and buddy both bought these. Top flew off and screw to hold it in fell out as well.
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Comments On May 07, 2012:The pole snapped on my first ride while going across the dunes at Little Sahara. There was no impact or nothing to hit. Was traveling approx 60mph and it just snapped off.
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mono is a mid-size family-owned enterprise headquartered in Mettmann, Germany, where it manufactures high-end quality flatware and table accessories.
The level of innovation, design quality, and superior manufacturing standards implemented for each and every item, have made mono what it is today – "a lifestyle enhancer".
|• Mono Filio
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mono Cups & Mugs (1)
Mono Filio Glass Teacups by Tassilo von Grolman (Set of 2)
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Mono-A Small Salad Serving Set by Peter Raacke
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Mono On Fire Concave Replacement by Franz Maurer
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These Men Waimea H2 flip-flops by Keen are a perfect catch for those looking out for better durability and traction. These sporty pair of footwear for men features simple style added with patented toe protection, an EVA midsole and a lightweight rubber outsole, which altogether offers greater comfort, traction and shock absorption to your feet on variety of surfaces.
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DEEP IN THE MUCK: Reporter Holly Haworth trudges through the hidden urban wilderness of First Creek.
A tire swing hangs empty under a bridge behind the First Creek Greenway.
A car bumper stuck between tree trunks gives evidence of recent heavy rains.
Grocery carts laden with debris punctuate a channelized part of the creek that flows under Interstate 40.
First Creek kayaker Bobby Braly counted 18 grocery carts between Grainger Avenue and the Tennessee River.
Behind Caswell Park, First Creek flows under the long-abandoned Standard Knitting Mill.
Kudzu creeps in to cover gray concrete walls that rise above the creek just behind Caswell Park.
Inside a tunnel, someone has scrawled a heartfelt message and drawn a vision of refuge.
The Standard Knitting Mill, with trees of heaven growing from it, rises above the creek at the edge of Parkridge.
UT professor John Nolt emerges from the half-mile underground portion of First Creek and faces the Tennessee River.


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Woodpigeon are an independent rock band from Calgary, Alberta, consisting of eight core members: Mark Hamilton (vocals, guitar), Kenna Burima (piano, vocals), Michael Gratton (bass), Annalea Sordi (accordion, flute, vocals), Daren Powell (drums), Peter Moersch (electric guitar, vocals), Foon Yap (violin), AJ Benoit (vocals). To date, the band have released three studio albums, and a number of EPs to mild critical acclaim. When asked about the band''s name, Mark Hamilton explains: "I''ve always been in love with the word Woodpigeon for as long as I can remember. When you write it in cursive, it looks like a rollercoaster". The band''s sound has been compared to Sufjan Stevens, Grizzly Bear, Camera Obscura, Simon & Garfunkel, and Belle & Sebastian, amongst others. Band leader Mark Hamilton''s main lyrical influence is The Kinks.
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Globalizing online content is more important than ever. The total spending power of online consumers around the world is nearly $50 trillion, a recent Common Sense Advisory report found. Three years ago, enterprises would have to translate content into 37 languages to reach 98 percent of Internet users. Today it takes 48 languages to reach the same amount of users.
For companies seeking to increase global market share, "translate frequently and fast" is the name of the game. Today's content is dynamic and ever-changing, covering the gamut from social media sites to company forums to press releases. With high-quality translation and localization, enterprises can tailor content to consumers around the world.
When it comes to the "frequently and fast" part of the equation, enterprises run into problems. Professional service providers provide translated content in files, which company workers then have to manually insert into their CMS. When companies update or edit source documents, they have to hunt down all the translated content and change each document individually.
Lingotek and Drupal have solved the problem by making the Lingotek Translation Management System fully integrated and interoperable with Drupal. Lingotek combines best-in-class machine translation solutions, real-time community/crowd translation and professional translation to enable companies to publish globalized content in an efficient and cost-effective manner. Drupal simplifies the creation and management of different types of content across multiple channels, including social media.
The fact is, with traditional translation methods, there's simply no way to keep up with today's continuously updated, socially-driven websites. Dynamic content needs dynamic translation! Watch a customer presentation..
Fortunately, Lingotek has developed a Drupal Inside integration to connect to our Lingotek Translation Management Systems. This provides a time and cost savings in itself, but even more powerful is the ability to engage any interested parties in the translation process be it bi-lingual employees, partners, or even customers.
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Translating web content using this integrated, collaborative tool isn't just superior to the old model of translation; it's the only way to keep up. Here are some of the massive benefits:
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'Uncanny X-Force' #1: Mutants Got Problems, Y'all [Review]
The X-Men have been through some pretty rough stuff. That's actually kind of their deal; "going through rough stuff" is the default setting for those mutants, and the only time they're not going through rough stuff is when they've either just finished going through something terrible or are just about to go through something terrible, two states that tend to coexist on two or three pages about twice a year.
Right now, though, the X-Men h


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Hang tight!
Recipe by Pamela and Victoria
"The name says it all. Large yield...it's mom's recipe."
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2 cups
graham cracker crumbs
1/4 cup
packed brown sugar
1/3 cup
butter, melted
1/2 cup
finely chopped walnuts
1 cup
semisweet chocolate chips
1/2 cup
packed brown sugar
1/2 cup
This was fabulous! I made recipe exactly as stated, except I took the previous advice and used 1/2 C butter for the crust, and the whole bag of chocolate chips. I used finely chopped almonds (toasted) - wonderful! A minute may be a bit long for the toffee to boil, as mine reached the soft ball stage by about 30 seconds, and I removed from heat at that point. It would have been way too hard if boiled any longer. Thanks to you both Pamela and Victoria for this entirely addicting recipe!
This SHOULD have been good but was not. First, the directions for the graham cracker crust were all wrong. There is not enough butter to make the crust form, and the cracker crumbs stayed just that... cracker crumbs... and did not adhere to the bottom of the toffee. So much for giving this as a gift.
Secondly, there was not enough toffee to cover the crumbs. It was a mess trying to spread it to the edges and I was not able to get any toffee into a couple of the corners.
Third, the completed bars were WAY TOO SWEET -- and I like sweet things, but this was sickly. The graham cracker crust with the brown sugar put it over the top. It would be much better with more of a minimally-sweetened shortbread base. More cookie-like and not sweet and crumbly.
I can't give this away along with my other Christmas cookies this year so am looking for a better recipe.
171 Ratings
I must say that at first taste I was not impressed, but these definitely are better the next day! My husband and I ended up loving them! I took other's advice and doubled the toffee layer, it really needs it and make sure to take the toffee off the burner as soon as it comes to a boil, do not boil for a minute afterwards. The only thing I will do next time is cook the graham cracker crust a few minutes less, it tasted a little burned around the edges. But I'll definitely make again, these were delish!
ok like some of the others i changed the recipe up a bit. first i changed the crust to 1 2/3 cups graham cracker crumbs, 1/3 cup brown sugar and 1/2 cup butter. for the toffee layer, i doubled the recipe and added a bit of vanilla. before i baked the crust i sprinkled on a thin layer of cocoa/powdered sugar to add a bit more chocolate taste. and like another reviewer, i cut the bars before completely cooled to make it easier and to keep them from falling apart. these are great right away or days later(assuming they last that long!) definitely a great recipe to have when you need to take something to a gathering, or just need a bit of a pick-me-up! love it!
I just LOVE this recipe!!! I make these anytime I have to take a dessert someplace. I've never met a single person who didn't like these toffee bars. It's worth the pain of stirring the toffee forever when you hear all of the rave reviews. BIG HINT: I use sliced almonds on top instead of walnuts - it makes the cookies look beautiful! Many people thought I had bought them from a bakery - they looked professionally done with the almonds on top.
WOW! I wish I could give this more than five stars. I was home alone when I tasted the result, and I exclaimed "Oh my gosh!" out loud. These were so good, and easy! I love brown sugar and toffee so the taste was perfect for me. Next time, I may double the toffee layer just to give it a bigger toffee taste. The toffee sort of sinks into the crust when you bake it the second time.
These are INSANELY good!!! I could eat the entire pan! They taste just like toffee so I'm not sure what another reviewer was saying that they didn't. The only thing I changed about this recipe was using pecans instead of walnuts (I simply didn't have any) and it was FABULOUS!!! If you have your heat too high then the butter sugar mixture will turn into a ball...otherwise will be fine. I boiled mine over a minute and it was great. I don't think it needs anymore chocolate...really, really great bar!! Thank you!
I made these for a bake-sale as a "sugar free option" and they were gone in less than 10 minutes! Do yourself a favor, buy a box of crushed graham crackers (they're sold in the baking aisle)to save time and aggrivation of crushing crackers.
I used splenda brown sugar and sf hersheys chocolate bars (chopped them up) for the top. unbelievably good!!
* Percent Daily Values are based on a 2,000 calorie diet.
Chocolate Toffee Crunch Bars
Serving Size: 1/24 of a recipe
Servings Per Recipe: 24
Amount Per Serving
Calories: 162
Calories from Fat: 97
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With spectacular photography from a Sunday afternoon at grand old Memorial Stadium, this poster celebrates a wonderful but long-gone era of Baltimore (and Buffalo) football. From the incredible action, to the old-school uniforms, to the tattered field, to the all-out effort of the good-old-days, this is a historical document that will make an incredible statement on your wall. Printed from original photographic sources, in an exclusive 20"x24" poster-sized edition for SportsPosterWarehouse.com, and complete with official NFL Properties hologram, this is both a beautiful poster, and a great collector's item for years to come!
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The Andean valley of the Cauca River, also known as the Eje Cafetero (coffee growing region), boasts the country's most fertile lands, which are under pressure from a growing human population. The valley, located in the southwestern part of the country, lies between two mountain ranges. The numerous streams that traverse it empty into the Cauca River. Among the threatened species found here are the Andean bear, Cauca guan—a large, fruit-eating bird, and mountain tapir.
A discovery of brown-spider monkeys in Parque Nacional Natural Selva de Florencia offers the critically endangered species a second chance.
©2015 Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, New York 10460, (718) 220-5100 | Terms of Use/Privacy PolicyRSS


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Nantucket Paisley Upholstery Fabric by the Yard by Angel Song
Subtle yet luxurious, this paisley textured fabric by the yard is great for creating nursery accessories and kid's room decor that will last for years to come. This gorgeous fabric, typically used on Angel Song's custom upholstered furniture pieces, is now available for you to use around your home. Whether in drapes, decorative pillows, throws, headboards, or covered picture boards, these beautiful fabrics will coordinate nicely with your Angel Song furniture piece or alone as a decorative piece in your child's nursery. This item is custom made especially for you upon order.
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While Gaithersburg High School students are making their final preparations as the academic year draws closer, their school continued its own steps this week to get ready for them.
The high school's new building showed signs of a long-term project undergoing its final stage: "Wet Paint" signs cautioned passers-by Monday, minor construction work produced whirs and beeps, and tables and other furniture stood ready for arrangement.
As she walked through the 422,000-square-foot building on Monday, Christine Handy-Collins, the high school's principal, said everything will be ready before school starts Monday.
"We'll be ready to rock 'n' roll," she said.
Gaithersburg High students will be among a group of county public school students passing through new doors this fall: Glenallan and Weller Road elementary schools in Silver Spring, Herbert Hoover Middle School in Potomac and Paint Branch High School in Burtonsville.
A number of elementary schools will open Monday with new additions, including Bradley Hills, Westbrook and Wyngate in Bethesda, and Georgian Forest and Viers Mill in Silver Spring.
Though Gaithersburg High still was in prep mode on Monday, it already showed signs of the activity it will hold starting next week. As varsity and junior varsity football players practiced on the new turf field and a group of band members practiced in an open commons area of the hallway, teachers trained in the new media center to learn about the high-tech Promethean whiteboards in their classrooms.
Senior Kelsey Semou said she was impressed with the size of the school, a factor she thinks makes it "stand out" in the county.
While she has seen the building when it still was under construction, she said actually entering the school brought out a "wow" from her.
"Just coming in, it's a different feeling," she said. "'Cause you're actually in the building, it's your school."
The school includes a new gym, a new cafeteria, a gutted and renovated auditorium and two courtyards, among a series of other new or improved features.
At the school's entrance, a visitor immediately walks upon a large gold and blue "G" paired with the head of the school's Trojan mascot decorating the floor.
"When you come into the building, you certainly know whose house it is," Handy-Collins said.
The old building will be torn down but for the auditorium and a 9-year-old wing once called "J hall" that now has an added third floor, Handy-Collins said.
The school's hallways all have college-based names — helpful in the large building — including College Park Drive, Towson Terrace, Salisbury Parkway, Frostburg Freeway and Johns Hopkins Highway.
Before students enter the school with classes on their mind, teachers and others were familiarizing themselves with the new layout and the elements that came with it.
For social studies teacher and football coach Kreg Kephart — and Gaithersburg High graduate of 1973 — the move into the new school marks a period of change and adaptation.
"It's like going from a little one-room schoolhouse to a great big Taj Mahal that's built next door or something," Kephart said.
Kephart said he will trade the portable classroom he taught in for 15 years for a classroom he described as "spacious" with "beautiful" desks.
He said he thinks the stadium field will be "comparable to none."
While teams are practicing on the field now, home games won't start until the 2014-2015 school year, when construction on the area around the field will be complete.
"The inconveniences that we went through the last couple years I guess are worth it in the long run when you look to see what we have once we finally get in here," Kephart said.
The $95.8 million school site still has a year left of its four-year construction process, Handy-Collins said.
Richard Bosnic — who began teaching at Gaithersburg in the late 1980s and described himself as "an old dog learning new tricks" — said the school environment when he started and the environment now is "night and day."
For Bosnic, preparing for this upcoming school year has meant learning how to use the Promethean boards, which were only introduced into some classrooms in the old building and represent one of several technologies he sees changing how kids learn and how he teaches them.
As the school community moves into the new building and becomes more deeply involved with the new technology, Bosnic said he doesn't know how it will pan out but that it sounds exciting.
"My guess is everything's going to change dramatically," he said.
Chris Taylor was found Monday where he will be teaching his media productions class with the help of a studio space strictly for filming, updated equipment and several editing suites to make "Blue & Gold TV" come to life.
"Our old studio, it was about the same size, but we also had all the computers in there so students were editing while other people were trying to film and it was very chaotic at times," Taylor said.
Among the athletes walking the halls on Monday, Damian Harkun, 16, said he was struck by the amount of space in the school and that he liked the building's design.
Though he had been at the school for football practice for several days, much of the campus still was new to him.
"I haven't even seen the whole building yet," he said. "I've only been to certain parts."
Though the building marks a significant change for the school, Semou said she thinks the school community will remain much the same.
"We're still going to have that Trojan pride we always had," she said.


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|Chelsea, Mich.
|High School:
|Little Caesars U-19
As a Junior in 2010-11: Saw action in 34 games…Scored two goals and two assists on the season…Her first goal of the season, which came on 11/26 against Sacred Heart, proved to be the game-winning goal in a 9-1 win…She collected an assist on 1/22 against Wayne State in a 3-0 victory…She registered a goal and assisted on the game-winning goal in a 4-2 win over St. Lawrence on 1/29.
As a Sophomore in 2009-10: Saw action in 36 games…Scored one goal and three assists on the season…Assisted on the game-winning goal against Northeastern on 10/17 in a 1-0 victory…Scored the game-tying goal in a 1-1 tie against Colgate on 11/20…Recorded an assist in an 11-1 victory over Sacred Heart on 11/28…Registered an assist in a 2-1 victory over St. Lawrence on 2/12.
As a freshman in 2008-09: Played in all 34 games last season on defense...Led all Rookies and ranked fifth on the team in scoring with 8 points (8 assists)...Picked up her first collegiate point when she assisted on the opening goal in the Bobcats' first win of the season over Syracuse on Oct. 17...Assisted defensive partner Trudy Reyns on the Bobcats' lone goal against Harvard on Oct. 31...Dished out the assist to Elyse Cole's game-tying goal against Cornell on Nov. 8...Assisted Kallie Flor at the Nutmeg Classic 3-2 loss to Wayne State on Nov. 28...Continued her point streak when she assisted fellow freshman Chelsea Illchuk against Princeton on Dec. 2...Earned her sixth apple of the year when she assisted Reyns' game-tying goal against Dartmouth on Jan. 2...Connected with Janine Duffy on a power play goal to tie the final score at 3-3 against RPI on Jan. 10...Contributed her final assist of the season on Feb. 7 when she dished a helper to Cole for the lone goal against Colgate.
Before Quinnipiac: Suited up for the Little Caesars U-19 Team... Played on teams that won NAHA Tournament, JWHL Tournament, and a Michigan State Championship and placed second in the National Championships... Earned Honorable Mention honors for the MWEHL...Served as captain or assistant captain in each of the last four seasons.
Personal: A native of Chelsea, Michigan...Daughter of Mark and Charlotte Perry...Has an older brother, Matt...Father played hockey at the University of Michigan...Graduated Summa Cum Laude from Chelsea High School, while earning the excellence in Physics and French awards...Majoring in physical therapy.


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6 June 2013Fiona Hyslop, Cabinet Secretary for Culture and External Affairs will today attend an event at Parliament celebrating the work of the Roman re-enactment group The Antonine Guard in promoting Scotland's Roman heritage. The group will give a talk and screen a film, The Mark of Rome, about the Bridgeness Slab project in Bo'ness.
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qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified N370S Glucocerebrosidase
Glucocerebrosidase (GC) catalyzes the hydrolysis of beta-glucocerebroside to glucose and ceramide in lysosomes. Mutations in the glucocerebrosidase gene result in Gaucher disease, an autosomal recessive lysosomal storage disorder. Many of the mutations encountered in patients with Gaucher disease are missense alterations that may cause misfolding, decreased stability and/or mistrafficking of this more ..
BioActive Compounds: 8
Related Experiments
NIH Chemical Genomics Center [NCGC]
NIH Molecular Libraries Probe Production Centers Network [MLPCN]
MLPCN Grant: MH086442-01
Assay Submitter (PI): Wei Zheng
Glucocerebrosidase (GC) catalyzes the hydrolysis of beta-glucocerebroside to glucose and ceramide in lysosomes. Mutations in the glucocerebrosidase gene result in Gaucher disease, an autosomal recessive lysosomal storage disorder. Many of the mutations encountered in patients with Gaucher disease are missense alterations that may cause misfolding, decreased stability and/or mistrafficking of this lysosomal protein. Some GC inhibitors have been shown to act as chemical chaperones, stabilizing the conformation of mutant proteins and thus restoring their function. These inhibitors include iminosugar analogs and three non-iminosugar inhibitors identified from a previous HTS of 62,000 compounds with the wild type recombinant enzyme. However, the enhancement of enzyme activity by the chaperone action of an enzyme inhibitor must be balanced against the direct inhibition of the enzyme. An enzyme activator could also function as a chaperone by binding to the enzyme and helping to correct its misfolding and mistrafficking. While activators for GC have not yet been identified, they may have better therapeutic potential than inhibitors. Therefore the discovery and development of chemical activators may provide a new strategy for the chaperone therapy.
We have optimized a new assay using N370S mutant GC derived from the spleen of a Gaucher patient. The primary screen assay differs significantly from the previous screen because the N370S mutant enzyme is used instead of wildtype GC and an enzyme preparation derived from patient tissue instead of the purified recombinant GC that should have the physiologically relevant subunit/subunits and cofactors. In addition, the MLPCN compound library has expanded, which increases the chance of finding new and better probes.
This assay characterizes compound activity using purified mutant enzyme instead of tissue homogenate. Compound activity differences may be due to the absence of endogenous cofactors found in tissue homogenate.
NCGC Assay Protocol Summary:
This is a fluorogenic enzyme assay with 4-methylumbelliferyl-beta-D-glucopyranoside as the substrate and purified N370S glucocerebrosidase as the enzyme preparation. Upon the hydrolysis of this fluorogenic substrate, the resulting product, 4-methyllumbelliferone, can be excited at 365 nm and emits at 440 nm which can be detected by a standard fluorescence plate reader. Data were normalized to the controls for basal activity (without enzyme) and 100% activity (with enzyme). The AC50 values were determined from concentration-response data modeled with the standard Hill equation.
Assay buffer: 50 mM citric acid (titrated with potassium phosphate to pH 5.0), 100 mM potassium chloride, 10 mM sodium chloride, 1 mM magnesium chloride, 0.01% Tween-20.
1536-well assay protocol:
(1) Add 2 ul/well of glucocerebrosidase enzyme solution (5 nM final)
(2) Add 23 nL compounds in DMSO solution. The final titration was 0.5 nM to 58 uM.
(3) Add 2 ul of substrate (1 mM final)
(4) Incubate at 37C for 40 min.
(5) Add 2 ul stop solution (1M NaOH and 1M Glycine mixture, pH 10)
(6) Detect the assay plate in a ViewLux plate reader (PerkinElmer) with Ex=365 nm and Em=440nm.
Keywords: Glucocerebrosidase, beta-glucosidase, Gaucher Disease, pharmacological chaperone, chaperone therapy, high throughput screening, glucocerebrosidase inhibitor, MLSMR, MLSCN, NIH Roadmap, qHTS and NCGC
Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.
Categorized Comment - additional comments and annotations
From ChEMBL:
Assay Type: Functional
Result Definitions
* Activity Concentration. ** Test Concentration.
Additional Information
Grant Number: MH086442-01
Data Table (Concise)


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University of Mississippi
European Pressphoto Agency
News about University of Mississippi, including commentary and archival articles published in The New York Times.
Chronology of Coverage
Apr. 3, 2015
Daniel W Jones, former chancellor of the University of Mississippi, rejects offer to return for two-year term before 2017 retirement; Jones, whose forceful stands for racial tolerance helped shift views on campus, received outpouring of support and protest following his ouster; says he refuses to take part in lame-duck tenure. MORE
Mar. 28, 2015
Former University of Mississippi student Graeme Harris is indicted on federal charges in connection with noose put on statue of James Meredith, student who integrated the campus in 1962. MORE
Mar. 26, 2015
More than 2,500 University of Mississippi students, employees and other supporters of Chancellor Daniel W Jones demonstrate against unexpected decision to remove him; criticize plan to change leaders as veiled in secrecy and perilous to future of university. MORE
Mar. 20, 2015
NCAA Tournament Roundup; Xavier University beats University of Mississippi, 76-57, in NCAA men's basketball tournament round of 64. MORE
Jan. 7, 2015
College Basketball Roundup; Kentucky holds off Mississippi, 89-86, in men's action; other men's and women's results noted. MORE
Jan. 1, 2015
College Football Bowl Roundup; Texas Christian University beats University of Mississippi, 42-3, in Peach Bowl; other bowl game scores noted. MORE
Nov. 30, 2014
Mississippi defeats Mississippi State, 31-17, in annual Egg Bowl; loss all but ensures that Mississippi State will not qualify for inaugural College Football Playoff. MORE
Nov. 23, 2014
Veterans Memorial Stadium in Jackson, Miss, is forever linked with racial hatred and segregation, but in October 1967, it was site of game between two historically black colleges, Jackson State and Grambling, that finally desegregated the arena; process of integration that game advanced is visible in current football season, with both Mississippi and Mississippi State ranked in top 10 with teams that include dozens of black players. MORE
Nov. 2, 2014
College Football Top 25 Roundup; Auburn defeats Mississippi, 35-31, in what amounts to the first College Football Playoff knockout game; other college football scores noted. MORE
Nov. 1, 2014
Football fans at University of Mississippi hold one of country's most elaborate pregame gatherings before every gridiron battle, on quintessentially Southern area of campus known as the Grove; with help of an annual party budget of $750,000 from the university, Rebels fans head for the Grove's 10 wooded acres to take tailgating to spectacular heights. MORE
Oct. 29, 2014
College Football Playoff selection committee reveals its first set of rankings, placing Mississippi State, Florida State, Auburn and Mississippi as its top four teams. MORE
Oct. 26, 2014
College Football Top 25 Roundup; Louisiana State upsets Mississippi, 10-7; other scores noted. MORE
Oct. 22, 2014
Profile of Hugh Freeze, coach at the University of Mississippi who has lead team up through the challenging Southeastern Conference to emerge as an unlikely force in college football. MORE
Oct. 11, 2014
Mississippi State and Ole Miss, perennial also-rans in college football, have toppled some football powerhouses this season in their ascent to share No 3 rank in the nation. MORE
Oct. 5, 2014
Mississippi scores upset Alabama, 23-17 and Mississippi State beats Texas A&M, 48-31, each scoring upset over an undefeated opponent. MORE
Aug. 29, 2014
College Football Roundup; Texas A&M defeats South Carolina, 52-28; Mississippi defeats Boise State, 35-13. MORE
Jun. 20, 2014
Mississippi defeats Texas Christian, 6-4, in College World Series. MORE
Feb. 22, 2014
University of Mississippi says students could face criminal charges for placing a noose on statue honoring James Meredith, college's first black student; fraternity Sigma Phi Epsilon says men were a part of group's chapter at the university, and that it had expelled the men and suspended the chapter. MORE
Feb. 21, 2014
Students say University of Mississippi needs to mount more aggressive stand against bigotry after two unidentified men placed a noose around statue of the school's first black student; minorities make up nearly quarter of student body, but reminders of university's Jim Crow past continue to permeate its idyllic campus. MORE
Feb. 19, 2014
Federal Bureau of Investigation says it has joined the inquiry into an act of vandalism at the University of Mississippi, where a statue of the university's first black student was found with a noose and a flag with the Confederate battle emblem. MORE
Dec. 9, 2013
College Basketball Men's Roundup; Oregon beats Mississippi, 115-105, in overtime; other men's and women's scores noted. MORE
Oct. 20, 2013
College Top 25 Roundup: Mississippi beats Louisiana State, 27-24; other scores noted. MORE
Oct. 5, 2013
University of Mississippi officials are investigating episode in which audience members heckled performers during theater department's production of play The Laramie Project, about an anti-gay hate crime; incident is seen as sign that school still struggles with the legacy of its integration in 1962, which resulted in two deaths and dozens of injuries. MORE
Mar. 25, 2013
La Salle defeats Mississippi, 76-74, in third round of NCAA men's basketball tournament. MORE
Mar. 23, 2013
Mississippi beats Wisconsin, 57-46, in NCAA men's basketball tournament second round. MORE
Mar. 22, 2013
Mississippi shooting guard Marshall Henderson relishes his role as South Eastern Conference villain, receiving plenty of attention ahead of NCAA tournament second-round match against Wisconsin, who have their own charismatic star--forward Mike Bruesewitz. MORE
Mar. 19, 2013
Profile of Mississippi guard Marshall Henderson, who has led his team into the NCAA men's basketball tournament with his scoring and antics on and off the court. MORE
Mar. 18, 2013
College Basketball Men's Roundup; Mississippi defeats Florida, 66-63, to win Southeastern Conference tournament championship, eliminating any NCAA tournament doubts; other men's and women's scores noted. MORE
Nov. 8, 2012
Student protest at University of Mississippi over the re-election of Pres Barack Obama turns disorderly, with some students chanting racial epithets and two arrested for disorderly conduct; university recently marked the 50th anniversary of the riots that followed its racial desegregation, and in recent years has addressed complaints of racial insensitivity on campus. MORE
Oct. 1, 2012
University of Mississippi is commemorating the 50th anniversary of racial integration on campus, but some question the tenor of the celebration and say it does not do enough to recognize school's painful history. MORE
Oct. 1, 2012
Op-Ed article by author Kitty Dumas marvels at the degree to which the issue of race in America has changed in 50 years since the University of Mississippi became integrated. MORE
Oct. 16, 2011
In Oxford, Mississippi, visitors can walk the former stomping grounds of William Faulkner and Archie Manning, experience the Ole Miss campus, and eat fabulously while doing so. MORE
There are no additional abstracts to display.
School Snapshot
Name: University of Mississippi
Location: Oxford, Mississippi
Type: 4 year, Public
Year Founded: 1844
Tuition and Fees (Fall 2008): In State- 5,107; Out of State- 12,468
Total enrollment (Fall 2006): 15,220
Undergraduate enrollment: 12,661
Undergraduate applicants (Fall 2006): 7,921
Percentage admitted: 83.9%
Graduation rate: 56%
Sports Nickname: Rebels
Official Web site: Olemiss.edu
Highlights From the Archives
Debate Host, Too, Has a Message of Change
The University of Mississippi will host the first presidential debate involving an African-American nominee, 46 years after race riots that killed two people.September 24, 2008 usNews
With Flag Gone, South Carolina May Host College Playoffs
The N.C.A.A. announced that the state's colleges could once again bid to host championships after the governor signed a law removing the Confederate flag from the grounds of the State House.
July 10, 2015, Friday
MORE ON UNIVERSITY OF MISSISSIPPI AND: College Athletics , National Collegiate Athletic Assn , Flags, Emblems and Insignia , South Carolina , Haley, Nikki R , Charleston (SC) , Spurrier, Steve , Clemson University , University of Mississippi
University of Mississippi Chief, Whose Ouster Led to Protests, Rejects Offer to Stay
Negotiations ended between Daniel W. Jones, who had been ousted as chancellor of the University of Mississippi, and schools officials, who had proposed a 2017 retirement.
April 3, 2015, Friday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Jones, Daniel W , Colleges and Universities , Demonstrations, Protests and Riots , Race and Ethnicity , Mississippi , University of Mississippi
Mississippi: Man Charged in Noose Display
A former University of Mississippi student has been indicted on federal charges in connection with a noose put on a statue of James Meredith, the student who integrated the campus.
March 28, 2015, Saturday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Colleges and Universities , Meredith, James Howard , Monuments and Memorials (Structures) , Hate Crimes , Blacks , Discrimination , Mississippi , University of Mississippi
Thousands Protest Plan to Oust University Chief in Mississippi
University of Mississippi students, employees and other supporters of Daniel W. Jones criticized the plan to change leaders as wrapped in secrecy and threatening to the future of a place that has often been central to the image of the state.
March 26, 2015, Thursday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Colleges and Universities , Jones, Daniel W , Demonstrations, Protests and Riots , University of Mississippi , Oxford (Miss)
Xavier, Big and Quick, Beats a Tired Ole Miss Squad
The Rebels were coming off a victory over Brigham Young in a play-in game, and they proved to be no match for the Musketeers.
March 20, 2015, Friday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Basketball (College) , NCAA Basketball Championships (Men) , Xavier University of Ohio , University of Mississippi
Hampton Earns a Shot at Kentucky
Reginald Johnson scored 15 points and made two critical defensive plays late in the game to lead Hampton to a win over Manhattan in an N.C.A.A. tournament play-in game in Dayton, Ohio.
March 18, 2015, Wednesday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Basketball (College) , NCAA Basketball Championships (Men) , Hampton University , Manhattan College , University of Mississippi , Brigham Young University , University of Rhode Island , Iona College
Kentucky Avoids Upset Against Mississippi
The top-ranked Wildcats were heavily favored to defeat the Rebels, but they needed overtime to scrape out a victory.
January 7, 2015, Wednesday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Basketball (College) , University of Kentucky , University of Mississippi
Georgia Tech Runs Past Mississippi State in Orange Bowl
The Yellow Jackets finished with 452 rushing yards in a win over the Bulldogs, improving to 2-8 in bowl games in the past 10 seasons.
January 1, 2015, Thursday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Football (College) , Orange Bowl (Football Game) , Georgia Institute of Technology , University of Mississippi , Prescott, Dak (1993- )
T.C.U. Crushes Ole Miss in the Peach Bowl
Texas Christian, left out of the four-team playoff, used three touchdown passes from Trevone Boykin and a dominant defense to win in a rout.
January 1, 2015, Thursday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Football (College) , Boykin, Trevone , Hackett, Chris , University of Mississippi , Texas Christian University
Mississippi Pulls Out of Its Skid and Leaves Mississippi State Adrift
The No. 18 Rebels (9-3, 5-3) beat the No. 4 Bulldogs (10-2, 6-2) on the strength of a feisty pass rush, solid play from quarterback Bo Wallace and a career day from tight end Evan Engram.
November 30, 2014, Sunday
MORE ON UNIVERSITY OF MISSISSIPPI AND: Football (College) , University of Mississippi , Mississippi State University , Mississippi
The Grove: Ole Miss's Living Room
The Grove at the University of Mississippi is a place of refuge. But on football game days the 10-acre space turns into one of the most raucous and distinctive tailgating parties in the country.
McCain Decides to Debate
John Harwood of The New York Times and CNBC discusses two gambles Senator John McCain took in recent days to regain campaign momentum.
New Era for Ole Miss
The first presidential debate took place at The University of Mississippi, 46 years after the race riots that greeted its first black student, James Meredith.
New Era for Ole Miss
The first presidential debate took place at The University of Mississippi, 46 years after the race riots that greeted its first black student, James Meredith.
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En español | Q. I am trying to quit smoking. Does Medicare have any programs to help me?
A. Yes. Medicare now offers free counseling sessions to help people kick the smoking habit.
See also: Quitting smoking — you can do it.
In the past, Medicare has covered antismoking counseling only for those who have already developed health problems from tobacco use. These sessions require a 20 percent copayment and are subject to the annual Part B deductible.
But the new benefit at last puts the horse before the cart: It's for people who have no symptoms of tobacco-related diseases but want to quit smoking before it harms their health. And there's no copay or deductible for this counseling, provided that you see a doctor or other qualified practitioner who accepts the Medicare-approved payment as full reimbursement.
Among the 46 million Americans who smoke, about 5.5 million are Medicare beneficiaries, according to the Department of Health and Human Services. And a recent CDC study (PDF) found that more than 50 percent of smokers age 65 and older said they wanted to stop completely.
Tobacco use is the leading cause of preventable illness, responsible for an estimated one-fifth of deaths in the United States each year, and by 2015 it will have cost Medicare $800 billion over a 20-year period, according to an estimate by the Centers for Disease Control and Prevention.
The new coverage allows up to two "quit-smoking" attempts a year, and each attempt includes up to four counseling sessions — a total of eight in any 12-month period. So if you have the first session in March, for example, and the next seven sessions don't break your habit, you can start another attempt the following March and have up to seven more sessions over the next 11 months, and so on.
What happens in these sessions? Medicare officials haven't released specifics, but recommend that doctors follow the "5-A" approach formulated by the federal government 11 years ago: ask patients about their smoking habits; advise them to quit; assess their willingness to quit; assist their attempts to quit; and arrange follow-up.
To help the process, doctors also may prescribe one of seven antismoking drugs currently approved by the Food and Drug Administration. These medications are covered under the Medicare Part D drug program.
Research shows that either counseling or medications are effective in helping people to quit smoking. "But what is most effective is when you combine the two," says Michael C. Fiore, M.D., professor of medicine and director of the Center for Tobacco Research and Intervention at the University of Wisconsin. "That's why Medicare now covering counseling is so important."


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Imagine your exhilaration as you reach the summit of a mountain in Canada's Yukon. Here you'll retrace historic Yukon trading routes, photograph wildflower meadows and sneak peeks at northern wildlife in their habitat. The Yukon's stunning landscapes beckon hikers from around the world for the ultimate hiking adventures, combining nature, athleticism and northern wilderness.
If there's a singular trait that defines hiking in the Yukon, it's the ability to traverse pristine larger than life landscapes without seeing a soul. Yukon hiking tour operators and their experienced guides are industry leaders, adhering to the highest standards for safety, wilderness skills and environmental responsibility.
Our Yukon Hikes
If you dream of finding the best hiking in Canada, plan a trek in Yukon territorial or national parks renowned for their incredible hikes. Tackle the challenging 100-km Donjek Glacier route or the 85-km Cottonwood Trail in Kluane National Park and Reserve, Yukon's World Heritage Site. Witness the explosion of fall colours on the tundra landscapes of magnificent Tombstone Territorial Park. Chart your own journey over the historic 53-km-long Chilkoot Trail used by First Nation traders and Klondike Gold Rush prospectors.
Enjoy unparalleled backcountry ridge hikes overlooking the Wind and Snake rivers. Explore the Dena Cho Trail connecting Faro and Ross River, the Ridge Road Trail in the Klondike goldfields, or the alpine trails crisscrossing Keno Hill. Meander along historic roads, hike under the midnight sun and stand atop pinnacles that reach for the sky...you're about to discover memorable hikes like Montana Mountain, King's Throne, Mount Haldane and Sapper Hill.
Take a Walk on the Wild Side
Before deciding on a specific walking or hiking route, it's a good idea to determine what level of challenge you're looking for. Are you an avid day-hiker who relishes the comforts of a lodge at the end of a day in the mountains? Is a 50-pound pack and two weeks without a shower your idea of a good time? Are you an experienced wilderness traveller, or would you rather be under the watch of a guide?
For adventurers seeking a few hours, a few days or even a couple of weeks of hiking, the Yukon offers unlimited possibilities. If a classic wilderness expedition is your goal, join a guided hiking trip on one of the Yukon's signature routes, from a few days on the Chilkoot Trail to a week or more in Kluane or Tombstone parks. If you're looking for a hiking trip with a twist, try hiking with huskies, heli-hiking or a creative journey with a spiritual purpose. Join a half-day walk on local trails near town, or take a van tour that features daily hikes in a new, wild corner of the Yukon.
It's Time to Start Planning!
Start your journey at the Yukon bookstore known for its great selection of northern titles. At Yukon Books you'll find guidebooks, narratives and maps describing everything from short walks to remote hiking routes. Learn the local natural and cultural history, and find out about traveling in bear country. Read about the Chilkoot Trail, routes and trails in Kluane and Tombstone, and the network of essential hikes and bikes around Whitehorse. Check with Parks Canada for information about hiking in Kluane National Park and Reserve or the Chilkoot Trail, and Yukon Parks offers information about Tombstone Park, Herschel Island and other territorial parks.
If you are inclined to do-it-yourself, Yukon outdoor equipment rental companies can outfit you with the gear you need and arrange your transportation. Make sure you have the necessary wilderness skills before you embark on your trip. Conditions can be unpredictable—good planning is the key to a safe and successful wilderness adventure.


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Seance on a Wet Afternoon (1964)
Kim Stanley plays a crooked medium who has become slightly unhinged since the death of her son. Craving money and publicity, she concocts a scheme with her weak-willed husband (Richard Attenborough). The pair will kidnap a wealthy young girl, collect the ransom, then use her powers to help the parents locate the child. The scheme falls apart, but not in the way that anyone might expect. Adapted by director Bryan Forbes from a novel by Mark McShane, Seance on a Wet Afternoon is a compelling psychological melodrama made doubly powerful by Stanley's mesmerizing performance.~ Hal Erickson, All Movie Guide
Cast: Richard Attenborough, Judith Donner, Mark Eden, Nanette Newman, Kim Stanley
Produced by: Richard Attenborough, Bryan Forbes, Jack Rix
Directed by: Bryan Forbes
Written by: Bryan Forbes
Running time: 2hr 1min
Opens: Jan 01, 2064
|Theaters for Today
Pick a day
on this day.


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I've invented a new product and started selling it (in very small quantities). No one else is selling this product. Can I apply for a patent for it?
Take the 2-minute tour ×
Ask Patents is a question and answer site for people interested in improving and participating in the patent system. It's 100% free, no registration required.
In the U.S. there is a bar against patenting anything that has been sold or even offered for sale that is 1 year after the first sale. Even if it is only one. If you want to patent outside the U.S. it is worse. In most locations it is too late to apply for a patent the day after you sell the first one.
To build on George's answer, if you have a new product, no doubt it will be improved as you get customer feedback. Those improvements may be patentable even if you have been selling your product for more than a year.


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Up to $1126 now. Keep it going.
Up to $1126 now. Keep it going.
Thanks everyone, John, Datruth55, csonka39,madodg88 and anyone else who is giving. We are doing great!
Keep up the good work and let's show the NY brothers and sisters that the Finheaven family is here for their family.
Keep it rolling!
Thanks everyone. I made a post about this last week, as I live in NJ and have seen how bad it is. My wife and I have already donated outside of the site and we have been volunteering in the area giving out water and clothing to those in need. Would just like to emphasize that if you do not have much moey you can still help by sending some of your clothing you may not wear much anymore. Also new socks, flashlights, batteries, canned foods, etc. are all helpful. Someone had said that they were collecting down in Miami and bringing stuff up here to NJ, not sure if it's still true. Thank you all for everything.
Can you give us an address where donations are being accepted?
XXL Tee on its way to NY8123 house!!!
"Frank's Redhot - I Put That **** On Everything!" ~ Ethel
I'm still without power guys but got my gloves and shovel digging everyone out...keep donating!
If you guys have an address to donate to.....I can get a pretty good size donation of clothes etc from here in TN.
Up to 1359$, made a 20 dollars donation. Wish I could do more but times are tough everywhere. Thanks for letting us know of ways we can help, and if someone could post where to send clothes to I'm sure we can find something to send..
Thanks so much for the donations! We will be putting up some new prizes soon.
For those who were asking for an address, there is a church in the Rockaways that's accepting donations by mail. They were one of the worst hit areas. Here is a list of supplies they are looking for: http://rockawayhelp.com/donate-supplies/
St.Francis de Sales Church
129-16 Rockaway Beach Blvd.
Belle Harbor, NY 11694
Dolfans NYC
The home of New York City Dolphins Fan Club.
Driven By Boredom
My NYC nightlife website.