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Aynsley Lister (born 14 November 1976 in Leicester) is an English blues-rock guitarist/singer and songwriter.
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St. Patricks Parade In Downtown Billings Was Fun But Scary
I had the great honor to drive the station van through the Downtown Billings St. Patricks Day parade. It was a blast! The crowd was huge and festive and people came decked out in green. I think my favorite costumes were the little leprechaun's who were wearing the fiery red strap-on beards

subset: commoncrawl


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The Ridgeback Velocity 2013 Hybrid Bike is built for commuting, offers the perfect combination of speed, comfort and practicality. Adaptable and stylish with the durability needed for everyday use. A short test ride…
The Ridgeback Velocity 2013 Hybrid Bike is built for commuting, offers the perfect combination of speed, comfort and practicality. Adaptable and stylish with the durability needed for everyday use. A short test ride of one of these benchmark commuter hybrids will confirm why so many people choose a bike from this popular category. With the strength of a mountain bike, road geometry and smooth rolling 700c wheels, the Rapide's sleek aluminium frame is built using size specific tubing to provide a responsive yet resilient ride.
Reliability is essential when a bike is used for daily transport. A full Shimano drivetrain ensures accurate and consistent shifting over time whilst Continental puncture resistant tyres make a significant contribution to many puncture free miles. Mudguard and rack fittings are standard on all Rapide models. With wide ratio gearing, ergonomic triple density grips and a comfortable saddle, a Ridgeback Rapide is commute ready as well as being a practical and fun way to get around town.
- Frame:
6061 heat-treated aluminium
- Fork:
- Front Derailleur:
Shimano TX51
- Rear Derailleur:
Shimano Altus
- Number of Gears:
- Shifters:
Shimano EZFire
- Chainset:
Shimano Altus
- Chainrings:
- Bottom Bracket:
- Cassette:
Shimano 11-32 Tooth 8 Speed
- Chain:
Shimano HG50
- Pedals:
Nylon Street
- Front Brake:
Tektro 836AL
- Rear Brake:
Tektro 836AL
- Brake Levers:
- Handlebars:
6061 Aluminium Lo-rise
- Stem:
Alloy Multi-position
- Headset:
- Grips:
Triple Density Lock-on
- Rims:
Rigida X-Pace 36h
- Front Hub:
- Rear Hub:
Shimano RM30
- Spokes:
Stainless steel black
- Front Tyre:
Continental Contact 700 × 37c
- Rear Tyre:
Continental Contact 700 × 37c
- Saddle:
City Comfort 2
- Seatpost:
Alloy Micro 27.2mm
- Weight:
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Are there meforshim on perek shira? I'm looking for anything besides artscroll. If there are many, which would you recommend to start?
Take the 2-minute tour ×
Mi Yodeya is a question and answer site for those who base their lives on Jewish law and tradition and anyone interested in learning more. It's 100% free, no registration required.
here is an archive of lots of shiurim on perek shira http://revach.net/avodah/perek-shira/19
I recommend Perek Shirah: Nature's Song, by R' Natan Slifkin. He does a great job of explaining both what Perek Shirah is all about and what each element can teach us. He combines traditional commentaries on both Perek Shirah and its source verses with his knowledge of zoology and other natural sciences, and provides precise citations of all his sources to facilitate further study.
Braisa Perek Shira by Rabbi Chaim Kanievsky Shlita


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The Narrows
"The Narrows" is the story of a young man facing one of life's most important crossroads. Mike Manadoro, a 19-year-old from Brooklyn, will do almost anything to get out of his neighborhood and to study photography at a Manhattan university. The problem is Mike's father Vinny, a retired sanitation worker, does not have the financial means to support his son's dream. So when local mob boss Tony offers Mike a high paying job, he takes it. Mike enters college at the same time as he begins delivering mysterious packages for Tony. Juggling new friendships, old loyalties, a new romance and the world of small-time crime, Mike's choices begin to result in dangerous and potentially fatal consequences for himself and everyone around him.
Cast: Sophia Bush, Kevin Zegers, Monica Keena, Vincent D'Onofrio, Eddie Cahill
Produced by: Leslie Urdang, Ami Armstrong, Tatiana Blackington
Directed by: François Velle
Written by: Tatiana Blackington, Tim McLoughlin
Running time: 1hr 46min
Opens: Jun 19, 2009 Limited
|Theaters for Today
Pick a day
on this day.


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- Independent
- The Enterprise
- The Recorder
In past years, the room has been filled with nearly 400 people, but attendance at this year's 27th annual Rev. Dr. Martin Luther King Jr. Breakfast fell to about 100 when many regular attendees decided to attend the second inauguration of President Barack Obama on Monday morning.
The annual breakfast, held at the Rod 'N' Reel Restaurant in Chesapeake Beach and sponsored by the National Congress of Black Women Calvert County Chapter, the College of Southern Maryland and the NAACP Calvert County Branch, celebrates Martin Luther King Jr. Day.
Hazel Trice Edney, the guest speaker, said, "I am here to tell you that we have not overcome."
She explained that the word "overcome" was heard so much during the civil rights movement, but "the thing that's been kind of nagging at me lately is you don't hear that anymore." She added that "we've kind of gotten quiet in that regard because we think we have."
She said there is a "unified struggle that still remains. … We've stopped too soon."
Edney, an award-winning journalist, is president and CEO of Trice Edney Communications and editor in chief of Trice Edney News Wire. She is also a professor of journalism at Howard University in Washington, D.C.
"One of the reasons that African-Americans, compared to other races, statistically are so destitute — in every bad category, we're the worst, and every good category we're the least. And the reason is because far too often, we come upon a place where we think it's OK to just rest," Edney said Monday morning. "But if we take a moment and survey our land, would we say we have overcome?"
She noted that there are thousands of children who have been killed on city streets and in cities across America and that more than 119,000 children and teens have been killed by gunfire since 1979, according to the Children's Defense Fund.
While nearly 30 percent of black children in this country live in households with not enough food, "we have not overcome.
"As long as this president of the United States has to be protected by twice the security force of any other president in history, we cannot say that we're finished," Edney explained.
She said that as long as the economic disparity of African-Americans remains in "the double digits … we cannot be finished."
"We must all remain ever vigilant [in] our posts" as long as "our children are not free to walk the streets of this nation without finding themselves in the cross hairs of racism," she said.
"Dr. King set the standard," Edney said, "when he said in his Aug. 28, 1963, speech, 'We will never be satisfied until justice rolls down like waters and righteousness like a mighty stream.' Has it rolled down yet?"
Edney said she believes that "if each one of us would do what we are called to do and if each one of us would press in to fill our God-ordained purpose, then perhaps the world's situation wouldn't be as it is."
She told the attendees there are three things people need to do to overcome.
Edney said the first thing is to "stop thinking when you should be praying." The second thing, she said, is to realize "it's not all about you." She expounded her thought, saying people need to forgive and help others. The last thing she said people need to do is to encourage themselves when crises come.
"We, indeed, may have overcome in some areas, but we have not yet landed," Edney concluded. "As Martin Luther King said, 'We have yet to get to the promised land.'"
Deborah Riley, the mistress of ceremony and vice chairwoman of the NCBW Calvert County Chapter, said 2013 is an "important, notable" year. "It marks 150 years since the signing of the Emancipation Proclamation," she said. "It marks 50 years since the 'I Have a Dream' speech and the March on [Washington, D.C.]. And it marks the start of the second inauguration for Barack Obama, the first African-American president of the United States."
She said Martin Luther King Jr. is "proudly" looking down "and thinking, 'We really have come a long way. Let's just keep it moving.'"


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Indiana Career Explorer Training: South Bend, IN
The Indiana Career Explorer, located at IndianaCareerExplorer.com, is a free tool for Hoosier K-12 students, college students and parents as they plan their education and career paths. Free trainings are available to schools, districts and colleges who wish to use the system. There is no cost for implementing the Indiana Career Explorer at your school.
A face-to-face, hands-on training session is the most effective way to learn about the Indiana Career Explorer. These sessions will cover the student component of the system (Kuder® Navigator) as well as the administrator component (Kuder® Administrative Database Management System). Attendees will receive a Quick Reference Guide and be directed to additional training resources online.
Wednesday, Nov. 28
Ivy Tech Community College – Columbus
Room 211
4475 Central Avenue
Columbus, IN 47203
Register Here!
Unlimited customer support and online training is available from Kuder at 877.999.6227 or email@example.com.


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Normally out of AZ/UT country but I find myself in northern Vermont with some free time. Any impressive engineering feats or awesome Fab shops to check out?
Results 1 to 5 of 5
Thread: On the road
05-15-2013, 10:37 AM #1Senior Member
- Join Date
- Nov 2012
- Location
- Northern Arizona
- Posts
- 571
On the roadMillerMatic 251
Maxstar 150 STH
Cutmaster 42
Victor Journeyman OA
A rockcrawler, er money pit, in progress...
05-15-2013, 10:49 AM #2Senior Member
- Join Date
- Jun 2009
- Location
- greenfield new hampshire
- Posts
- 895
ben and jerries icecream
05-15-2013, 11:12 AM #3Senior Member
- Join Date
- Sep 2005
- Location
- WY...armpit of U.S.A.
- Posts
- 659
Doesn't fit in either of your categories, but Plaza Machine is over in Bethel, VT. If you need any parts or tooling for any of your shop equipment it would be worth a stop.Miller 251...sold the spoolgun to DiverBill.
Miller DialArc 250
Lincoln PrecisionTig 275
Hypertherm 900 plasma cutter
Bridgeport "J" head mill...tooled up
Jet 14 X 40 lathe...ditto
South Bend 9" lathe...yeah, got the change gears too
Logan 7" shaper
Ellis 3000 band saw
Hossfeld bender w/shopbuilt hyd.
Victor Journeyman torch and gauges
3 Gerstner boxes of mostly Starrett tools
Lots of dust bunnies
Too small of a shop at 40 X 59.
05-15-2013, 12:29 PM #4Senior Member
- Join Date
- Nov 2012
- Location
- Northern Arizona
- Posts
- 571
Nice start. Ben and Jerry's is on the list. Got to have priorities. Magic hat and otter creek also made the list.
I'll see about the machine shop. Who knows what I can convince myself to buy. Last time I went on a jet plane ride for vacation I carried a cst280 on the plane home. That was an interesting security screening.MillerMatic 251
Maxstar 150 STH
Cutmaster 42
Victor Journeyman OA
A rockcrawler, er money pit, in progress...
Check out www.yankeemagazine.com
Might be interesting to stop by a black smith shop.


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JOHNSONBURG – The Johnsonburg Municipal Authority recently adopted a drought contingency plan requested by Department of Environmental Protection [DEP] officials.
Authority members voted unanimously in favor of adopting the drought plan as drawn up by Uni-Tec Consulting Engineers Inc. for the water agreement with the Hunt Marcellus Operating Company.
Chairman Eric Poague discussed the criteria for the various trigger points to be used by Authority officials in identifying the various onset of drought response levels in the system.
"DEP [officials] requested we come up with a drought situation plan out at the dam in Silver Creek and the one out at Powers Run," said authority member Ed Gapinski during the Johnsonburg Borough Council meeting. "If the water in Silver Creek reaches two feet, one inch below the dam wall, we no longer will sell to them. If the water reaches two feet, two inches below the wall at Powers Run we will not sell the water."
Pick up a copy of the Friday, July 15, 2011 edition of The Ridgway Record for more.
[1] http://www.ridgwayrecord.com/sites/default/files/IMG_8958 COLOR.jpg


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The Canary Islands, an adventure all the year round.
Travel ideas
…(Canary Islands) Climate, landscape, orography, wind... The Canary Islands have all the ingredients for the practice of adventure sports. Come and see for yourself. With their hot summers and warm winters, the Canary Islands are the ideal destination for enjoying activities in the open air all the y…
The Canary Islands - sure to please.
Travel ideas
…(Canary Islands) Seven very different islands that do have some things in common: crystal-clear waters, year-round summer temperatures, a broad range of leisure activities available and, of course, beaches. Is this your idea of good holiday? It is all awaiting you in Spain, less than four hours flig…
Do you like the sea? Then you'll love Fuerteventura.
Travel ideas
…Fuerteventura. (Canary Islands) Fuerteventura, one of the seven Canary Islands, is a paradise for anyone who loves water sports. Windsurfers can make the most of the outstanding waves and wind conditions. Scuba-divers will also be able to explore spectacular sea beds. And if you're the type who love…
Reserves of the Canary Islands: Paradises of Native Flora and Fauna.
Travel ideas
…(Canary Islands) The work and gift of evolution, each island of the Canary Islands jealously hoards its rare animals and plants—species so valuable to science they would captivate Darwin himself. They are the most outstanding elements of the Canary Islands' lush natural environments: four national p…
A volcanic experience in the Canary Islands.
Travel ideas
…(Canary Islands) Did you know that the Canary Islands are volcanic in origin and are home to one of the largest volcanoes in the world, the Teide, Spain's highest mountain? This is why the islands are so unusual: you'll find everything from volcanic craters to lunar landscapes, combined with deserts…


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Jim Campilongo talks about his recording band and the making of his latest album, Dream Dictionary, as well as demonstrating how he plays "Nang Nang."
The Yardbirds 2015 Tour Kicks Into High Gear With Bassist Kenny Aaronson
Live Coverage From the 2015 Warwick Bass Camp
Eagles of Death Metal Announce New Album, Hit the Road With Bassist Matt McJunkins
Alberta Cross Announce New LP
Shure Intros ULX-D 900MHz Digital Wireless Systems
Dwarfcraft Devices Releases New Pitch Shifter
At last, a box to convert MIDI to old-school DIN sync and back again
Roland launches System-100 plug-out synthesizer
Malcolm Cecil among highlights at Chicagoland synth meet Knobcon 4
Gary Clark Jr. Premieres "Grinder" Music Video
Ghost Pedal Creates Wah Effect Without Physical Pedal | Video
Gabriella Quevedo Plays Fingerstyle Arrangement of The Beatles' "While My Guitar Gently Weeps" | Video
Watch Slayer's 'Raining Blood' Performed with Hand Farts
Hate Eternal Announce Headlining Tour
Listen to Doomy New Slayer Song, 'Cast the First Stone'
"Boogie Uproar" — The Up-Tempo Soloing Style of Clarence "Gatemouth" Brown
Buskers' Rights: Know the Laws of Street Performing
George Lynch Talks Inspiration and the New Lynch Mob Album, 'Rebel'
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[UPDATE: This story was originally published on April 30, 2012.]
If there's one thing we want to do on the weekends it's…well…nothing! And while the Bay's plethora of lush parks are definitely conducive to outdoor chilling, we're also lucky enough to have a host of alternative, more urban R&R spots in the form of the parklets popping up all over town. The best tiny, park-like structures make their home in the parking spaces in front of some of the coolest city spots (Four Barrel, Delfina, Trouble Coffee, and Farm:Table among them), and they don't just consist of a few uninspired tables and chairs on the sidewalk. Instead, the mini venues are getting made over by some of the coolest design firms and creative types in town. Don't believe that these auto zones can be jazzed up to stunning effect? Just take a virtual walk through our slideshow and plan your summertime sit-ins accordingly.
Photographed by Christine Ting
Photographed by Christine Ting


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Baby enjoys the soft, delicate sounds produced by the sweet-sounding Baby Giraffe wind-chime, stimulating both her sense of sight and hearing.
Baby spends much time watching the toy dangling above her, randomly reaching out with her hand and batting at the toy, causing it to swing and make pleasing sounds – a captivating effect that encourages her to try time and again.
Use the clip to hang Baby Giraffe on your baby's infant seat.
Hang it on baby's stroller as an on-the-go toy.
Place it in baby's crib for fun and play indoors.
When baby tries to reach her hand out to touch Baby Giraffe hanging in front of her, she lifts her arm as one unit, an action which starts where her arm meets her shoulder, strengthening her arm muscles. These muscles are part of the muscle group used when developing gross motor skills.


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For over two decades, Benchmade has been committed to designing and manufacturing world-class sports cutlery and edged tools. We continually strive to manufacture high quality products that will deliver superior performance and provide great value for our customers. Whether you are using a Griptilian® as a basic cutting tool or one of our professional-grade rescue hooks to perform a quick cut in an emergency situation, you can count on your Benchmade to get the job done.
Gold Class | Blue Class |
Black Class | H&K®
Knives | Knives & Safety Cutters |
Pen Series
Accessories, LEDs & Tools


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$1.95 Flat-Rate Shipping LABORDAY195
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text: GUCCI AND THE ARTS Encounters:Valerie Belin Gucci And The Arts The Language of FlowersNew Contemporary Art Exhibition THE MUSEUM Blossoming BooksDiscover the Bookstore selection Gucci Archive Gucci and the Arts The Museum Gucci Stores Share with friends close Please check and edit the highlighted field(s) below to proceed Your name Your email Your friend's name Your friend's email Add more friends Your friend's name Your friend's email Your friend's name Your friend's email You may add up to two additional friends personal message (optional) I would like to share the following item with you from Gucci Museo send me a copy of this email this information will not be used for any purpose other than the sending of this email. Submit Cancel Message sent Thank you. Your email has been sent. Send another email


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The Community of Disc Golfers and About All Things Disc Golf
Views: 11
Im looking for tips on what and how to throw with elevation changes, up and down hill.
uphill - it's good to throw understable discs with some height. let the disc travel back there, not get there and fall. a lighter disc or anything with good glide makes this easier.
downhill - stable and overstable discs are more predictable because it can be hard to tell how the wind/changing elevation/changing air conditions from the hill will affect the disc as it falls. there are a lot more unpredictable factors throwing downhill. understable discs are still an option though and can produce massive drives, especially downwind
What he said.
I'll add that, for big downhill throws, throw downhill. It may seem obvious, but I see people throw straight out off a big hill; the disc ends up very high off the ground, stalls and falls hard. There's more distance if you throw, more or less, along the grade.
Some tasks need to be learned by doing, including throwing up and down hills.
It would be difficult to learn how to swim or ride a bike or give a speech in front of a large audience without actually doing it.
In disc golf you cannot just imagine hills or strong winds or playing a final nine in front of a big gallery and be properly prepared for the real thing. You must do it to understand it.
Playing hills is not just throwing up or down. It is also throwing from lies which themselves angle up or down or on sidehills to basket locations which are up or down or on sidehills: then factoring in distances and winds.
Of course, once you throw those shots you must also make putts which may be up, down or sidehill and worry about drop-offs and roll-aways.
So throwing with elevation changes is just like throwing on flat land but harder and more complex.
© 2015 Created by Terry "the Pirate" Calhoun.


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Processing Time - Orders typically ship in 2-5 business days. Transit via UPS Ground can take up to 6 business days. Braided and custom-made products may take 2 to 3 weeks for delivery.
Free Shipping to Contiguous United States - We do not ship to Alaska, Hawaii or the Caribbean Islands at this time.
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Inspired by antique lighting,this series recalls turn-of the century farmhouse style,with simple,yet functional design details. This fixture is height adjustable by simply pulling down or lifting up on the handle. Finished in Bellwether Copper and Antique Brass.
- Collection: Farmhouse
- Brand: Elk Lighting
- Material: Metal
- Styles:
- Available in the following sizes: 71" H x 8" W
Fill out the information below.


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"Holiday Cheer Photo Ornament"
By Pamela
Comments: My son loves his new ornament. He wanted to upload a photo of him and his best friend and give it to his best friend before holiday vacation. Such a neat idea and quite creative. thank you!


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Practice Philosophy
Dr. Tiffany McCormack is a board-certified plastic surgeon in Reno, Nevada who strives to provide her patients with beautiful, natural-looking results. As a female plastic surgeon, Dr. McCormack has an insight into what many women go through as they age and she understands the physical changes that can often occur after certain events in their lives, such as weight loss or pregnancy. Many of her patients find successful rejuvenation after these changes through procedures such as a mommy makeover or post-bariatric surgery. Some of the other popular procedures at her Reno plastic surgery practice include breast augmentation, tummy tuck, facial rejuvenation, cellulite reduction, non-invasive injectables, and liposuction. Dr. McCormack is also skilled in breast reconstruction for post-mastectomy patients.
Dr. McCormack believes that staying in communication with her patients helps to produce the best possible outcome. She works hard to ensure patient satisfaction by placing a priority on her patients, above all else. Dr. McCormack is available to her patients to answer any questions or concerns, and personally reads and responds to all of her patient e-mails.
After medical school, Dr. McCormack was trained in plastic and reconstructive surgery at the prestigious Stanford University Medical Center. She maintains and supplements her knowledge through continued medical education, ensuring she is well-informed on the most advanced procedures and technology. She is a Fellow of the American College of Surgeons, and stays active in some of the most respected medical societies in the world, such as the American Society for Aesthetic Plastic Surgery and the American Society of Plastic Surgeons.
Cosmetic Surgery, Breast Surgery, Reconstruction, Body Surgery, Facial Surgery
Dr. McCormack believes it is important for her to be available to her patients for answers and support at every stage of their procedure. The first step in this process is the consultation. In your consultation with Dr. McCormack, she will ask you to explain your aesthetic goals, so she can tailor a customized treatment plan to meet your needs. She will explain any options available that she feels will help you to achieve your goals, and through her expertise, she will help you to select the method that can best fit your desires and lifestyle. If the procedure you request will not achieve the outcome you seek, Dr. McCormack will advise against it, and recommend other options. She may also suggest additional procedures if she feels they could assist in achieving your aesthetic goals. Dr. McCormack believes it is important to educate her patients, so there are no surprises along the way - her goal is to make sure her patients are well-prepared, so they will know what to expect throughout their experience.
Patient safety is extremely important to Dr. Tiffany McCormack and her staff. She only performs surgeries at fully accredited facilities. Her Reno plastic surgery practice is affiliated with Renown Regional Medical Center, Saint Mary's Hospital, and Renown South Meadows Hospital. All three of these Reno hospitals are regularly inspected and re-certified by The Joint Commission, ensuring the highest level of patient care and safety.
Location & Office Hours
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Coping With Fear of Recurrence [1]
The end of cancer treatment can bring both relief and worry. You may be relieved that your treatment is finally over and pleased that your cancer is in remission (the temporary or permanent absence of cancer). However, you may also feel worried, anxious, or fearful that your cancer may recur (come back).
Cancer recurrence is the return of cancer after a period when no cancer cells could be detected in the body. The fear of recurrence is normal and reasonable for cancer survivors, especially during the first few years your cancer is in remission. It is important to remember that although you cannot control whether your cancer recurs, you can control how much you let the fear of recurrence affect your life.
Tips for coping
Accept your fears. It is common to experience some fear about your cancer recurring. Telling yourself not to worry or criticizing yourself for being afraid won't make these feelings go away. Accept that you are going to experience some fear and focus on finding ways to help yourself manage the anxiety [2].
It may also help to remember that the fear usually lessens over time, and that you won't always feel so anxious. Be aware that your anxiety may temporarily increase at certain times, such as before follow-up care appointments, around the anniversary date of your diagnosis, or if a friend is diagnosed with cancer.
Don't worry alone. Talking about your fears and feelings or writing down your thoughts in a journal [3] can help reduce your anxiety. Talking and thinking about your concerns can help you explore the issues underlying your fear. Fear of recurrence might include fear of having to repeat cancer treatment, losing control of your life, or facing death.
Many cancer survivors find joining a support group [4] to be helpful. Support groups offer the chance to share feelings and fears with others who understand, as well as to exchange practical information and helpful suggestions. The group experience can also create a sense of belonging that helps you feel less alone and more understood.
Talk with your doctor about regular follow-up care. After finishing treatment, you may find it helpful to have a record of your treatment and a plan for your follow-up care. Find out more about cancer treatment plans and summaries [5] and how they can help you develop a customized follow up care plan with your doctor. Thinking of yourself and your doctor as partners in charge of your health care decisions helps you feel more in control.
Be well informed. Most cancers have a predictable pattern of recurrence. Although a doctor cannot tell you exactly what will happen to you, an oncologist familiar with your history will be able to give you specific information about whether the cancer might recur and what symptoms to look for. Knowing what to expect can help you stop worrying that every ache or pain means your cancer is back.
Adopt a healthy lifestyle. Eating a well-balanced diet [6], exercising regularly [7], and getting enough sleep helps you feel better physically and emotionally. Doctors do not know why cancer recurs in some people and not in others, but avoiding unhealthy habits, like smoking [8] and excessive drinking [9], may help reduce the risk of recurrence. Adopting a healthy lifestyle will also lower your chances of developing other health problems. Read more about making positive lifestyle changes [10].
Reduce stress. Finding ways to lower your stress will help lower your overall level of anxiety. Experiment with different ways of reducing stress to find out what works best for you.
- Spend time with family and friends
- Spend time on hobbies and other activities you enjoy
- Take a walk, meditate, or enjoy a bath
- Exercise regularly
- Find time for humor—read a funny book or watch a funny movie
- Join a support group
- Avoid unnecessary stress—don't take on unnecessary responsibilities or commit yourself to tasks you don't have time for
- Simplify your life
Learn more about managing stress [11].
When you need more help
Despite your best efforts to stay well, you may find yourself overwhelmed by fear or recurrent thoughts of illness. If in doubt, talk with your doctor or nurse and consider a referral for counseling. Read about the benefits of counseling [12].
The following feelings may point to a diagnosis of anxiety or depression:
- Being worried or anxious most of the time, so that it gets in the way of your relationships or work, or prevents you from going to your follow-up care appointments
- Feeling hopeless about your future
- Having trouble sleeping or eating well
- Not participating in activities you used to enjoy
- Having trouble concentrating or making decisions
- Being unusually forgetful
More Information
Dealing With Cancer Recurrence [13]
Telephone and E-Mail Helplines [14]
Anxiety [15]
Depression [16]
Additional Resources
LIVESTRONG: Fear of Recurrence [17]
National Cancer Institute: Facing Forward Series: Life After Cancer Treatment [18]


text:
'Francescos is the number one rated accomodation from backpackers in all of Ios...' Plus d'info »
As No 1 choice the Far Out Beach Club is a backpacker's paradise, located right on Mylopotas beach, offering a... Plus d'info »
Avra is a small comfortable pension situated in the port of IOS. It is next to Gialos beach, the shopping center and... Plus d'info »
IOS RESORT is the place that all the backpackers have been raving about and gave a 99% rating the highest ranking of... Plus d'info »
Situe au coeur de 'Chora' (celebres pour ces moulins blanchis au lait de chaux), les chambres sont a proximite des... Plus d'info »
Holidays In Ios is a family owned accommodation complex located at the beach of Mylopotas, the fifth best beach in... Plus d'info »
no age restriction, everybody is welcome at ios hostel!!! children are also welcome of course... the reception is... Plus d'info »
Located in the centre of Ios Town, Vesuvio Chora is traditionally built in Cycladic style. It offers self-catered... Plus d'info »
Built in the traditional island style, the hotel has many charming features such as a delightful interior courtyard,... Plus d'info »
Galaxy est un hôtel familial et il est construit avec la philosophie des bâtiments des Cyclades. Les clients... Plus d'info »
Galini Pension is a family run business,all standard rooms are well equipped with modern facilities, WiFi,air-con,... Plus d'info »
As of 2006 we reopen the newly refurbished Far Out Hotel with a totally new SPA. With the calming view of the Aegean... Plus d'info »
All rooms have private bathroom, and are featured with TV, A/C, fridge, hair dryer. We also provide free Wi-Fi,... Plus d'info »
The air-conditioned units have a private entrance and are appointed with white-washed walls, tiled floors and wooden... Plus d'info »
British management. Small, family run business. Rooms include 24 hour hot water, towels, fridge, air-conditioner,... Plus d'info »
Within 300 metres from the sandy Yialos Beach in Ios, the Cycladic-stlye Vesuvio Kampos offers self-catering units... Plus d'info »
Please Note: Cancellation policy: 72h before arrival. In case of a late cancellation or No Show, you will be... Plus d'info »
Rooms with refrigerator, air conditioning, hair-drier, Wi-Fi and amazing view of the island and the sea, only two... Plus d'info »
Au coeur d'Ios, magnifique île des Cyclades aux plages dorées qui s'étendent à perte de vue, le Village de Markos est... Plus d'info »
George and Irene Hotel comprises of 12 spacious and sunlit units that offer comfortable and relaxed accommodation... Plus d'info »


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Step 1: Glue together Wood
48"X1/2" Oak trim piece
24"X1/2" Poplar trim piece
bottle of gorrila glue
Stanley hand planer
bundle of jute rope (In the future, hemp would probably be better)
The hand planer from lowes turned out to be just the ticket for shaving down the bow arms to what I needed. Its only 6 bucks and its about 3"X1" big. Any bigger would probably turn out to be too unweildy. Any sort of wood glue would work really.. as a matter of fact, gorrila glue is probably not the best one to use. The wood was just some project wood or you could use trim wood too, I guess.
This is pretty self-explanatory, just make sure you get the glue more evenly spread than it is in this picture. Use sticks and rope as a clamp and the piece until its cured enough to release. This should actually take a few hours but since I'm really impatient, I waited for half an hour and then started carving. Dont do that, it just messes things up in further steps. Whatever you do, don't try bending the bow until the glue is dry either. This just makes them pop apart.
This is not an Insructable rather an add for his site.
What did you use for a bow string?
What is the draw weight of this bow? I am trying to make a 50 pound draw weight bow for myself but nobody ever puts the draw weight in their instructions
i made a piramid longbow and it is 75 lbs at 28 this is probably 30-45
How do you bend the bow? Your tutorial doesn't say how to.
How much is the pull weight? How heavy is the bow?
Any wood that is strong can be used. Flexible is also a feature to look for. Bows can be made of more than one wood also, with layers to make for a different behavior altogether.
Fiberglass is also a great material for making bows.
A jig is easy to set up with 2 nails and a plank of wood.
Set the nails partway in a plank of wood about as far apart as the string should be long.
Wrap 7-8 times around the nails with floss. Tie ends together so you have a big loop.
Now wrap floss tightly in a spiral over 4inch sections in the middle of both sides of the loop.
Slide the wrapped sections so they are around the nails.
Now wrap floss tightly both sides together about a 4 inch section in the middle for the arrow notch.
Pinch together the wrapped sections at each end to form a hole for the bow ends and wrap tightly with floss. Now you can take your finished string off the nail jig.


text: Magnificent contemporary villa in the heart of one of the few private estates in California area, built on two levels with large terraces and panoramic views over the bay of Cannes.Located in one of the few private estate of the Californie, on the residential heights of Cannes, only 10 minutes drive from the Croisette, beaches, restaurants and Congress Center. Nice International Airport: 30 minutes The entrance hall of this villa leads directly to the living / dining room enjoying fantastic views over the bay of Cannes. Fully equipped kitchen Master's bedroom opening onto a terrace with exceptional sea view, bathroom with shower and toilet, dressing. Groundfloor level: The first bedroom opening onto the terrace, bathroom with toilet, dressing. Second bedroom with shower room and toilet, dressing. Another bedroom opening onto a terrace with sea views, bathroom and toilet. Dressing. 4th bedroom with shower and toilet. Independent entrance. CM4438


text:
On-campus dining at Truett-McConnell is provided by Chartwells. All resident students must purchase an unlimited access meal plan. In addition, there are several options available to commuter students. Please refer to the listing below for a brief description of each:
We will offer the following plans for resident students:
Unlimited meals w/ $25 in Bear Bucks per semester:
Education Major and Nursing Major Declining Balance Plan:
Commuter Student Declining Balance Plan:
Faculty and Staff Declining Balance Plan:
For current prices visit: http://www.truett.edu/tmcadmissions/tuition-and-fees.html
Please visit the Business Office in the Miller building for more information on purchasing a meal plan.
Please visit Chartwells http://www.dineoncampus.com/truett/ for health and nutritional information.
Dining Hall Hours:
Monday – Friday
Breakfast 7:15-9:00am
Lunch 11:00am – 1:30pm
Dinner 4:30 – 7:00pm
Saturday and Sunday
Brunch 10:00am – 2:00pm
Dinner - 4:30pm - 6:00pm
Outtakes Hours
Monday – Wednesday
7:30am – 2:30pm
7:30am – 9:30am / 10:30am – 2:30pm
7:30am – 11:30am
For the weekly cafeteria menu, visit: http://www.dineoncampus.com/truett/show.cfm?cmd=menus2
We are Truett: Charissa Veal
By Jordan West
CLEVELAND, Ga. (TMNews) – Senior English major,… Read More
We Are Truett: Charity Estes
By Charissa Veal
CLEVELAND, Ga., (TMNews) – Graduating senior, Charity… Read More
We are Truett: Phillip Simmons
by Andrea Towns
CLEVELAND, Ga., (TMNews) – A junior Music… Read More
We Are Truett: Nikki Cross
CLEVELAND, Ga. (TMNews) – Originally from Butler, Ga., Senior Nikki… Read More
Professor Hennigan and students gather around for a lesson in the woods at TMC.… Read More


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I'm needing to plan a work party to plan for our next tournament, which is hopeful for late January. I've been out there every weekend, but I can only do so much with my little chainsaw. In addition to adding the new downhill hole, I'm wanting to improve/lengthen a few of the existing holes.
Please respond if you might be able to help.
When? At any point between now and mid January!


text:
Diversity Statement
Wright State University celebrates diversity. Our daily life is made rich by the diversity of individuals, groups, and cultures. The interplay of the diverse stimulates creativity and achievement in all facets of our existence.
Respect, tolerance, and goodwill are the keystones to enjoying the diversity of our world. We are all linked to each other in a world created for all of us to share and enjoy. Each member of humanity has a potential contribution to make to the whole. It is our duty to encourage and promote that contribution.
Wright State University is committed to achieving an intellectual, cultural, and social environment on campus in which all are free to make their contribution. We will achieve an environment in which every student may think, learn, and grow without prejudice, without intimidation, and without discrimination. We will achieve an environment in which personal dignity and respect for the individual are recognized by all.
Wright State University promotes the acceptance and appreciation of every individual regardless of race, gender, age, ethnicity, ability or disability, sexual orientation, socioeconomic status, religious affiliation, or national origin. We encourage appropriate activities and events that foster learning about the diversity of our world.
Wright State University will be a model for our geographic region, exemplifying that a human community can exist that celebrates diversity, enjoys the richness that diversity brings to our lives, and grows stronger with every new member.
Adopted by the Wright State University Board of Trustees, March 28, 1991.
Strategic Plan
- Empower
- Goals
- Implementation Results
- University Overview
- Advancement
- Athletics
- Boonshoft School of Medicine
- Business and Fiscal Affairs
- College of Education and Human Services
- College of Engineering and Computer Science
- College of Liberal Arts
- College of Nursing and Health
- College of Science and Mathematics
- Communications and Marketing
- Curriculum and Instruction
- Enrollment Management
- Lake Campus
- Multicultural Affairs and Community Engagement
- Nutter Center
- Office of the Vice President for Research
- Raj Soin College of Business
- School of Professional Psychology
- Student Affairs
- Wright State Research Institute
- Strategic Plan Committee


text:
The Community of Disc Golfers and About All Things Disc Golf
Having worked for many years at a large retail Automotive operation, I understand and appreciate customer feedback. The more responses I get, the better my analysis of how we are doing will be. The PDGA is affording us the same type of opportunity to sound off on how they are doing and which way they should go. Please take this opportunity to fill out the survey. It has some length to it, and is very specific in a wide amount of areas, well worth the time to respond.
Views: 225
There is an open section at the end....keep going
I took the survey a week ago. I was kind of disturbed by the possible responses to the question about sponsorship. The last two choices were 'Men's club' and 'Men's themed restaurants' . Although I would appreciate sponsorship in any form (except tobacco products), I believe these choices would only serve to further alienate women from our sport. I just got back from the Worlds, and although there were plenty of women playing, the movie and dinner both seemed like sausage fests. Overwhelmingly white sausage fests.
We're not going anywhere with this sport without more mass appeal than we have now. IMHO we need many more women and people of ALL colors playing this greatest of all sports.
Now, would someone please help me down from this soapbox, I'm kinda old. And white. And male.
Heck there are Clubs out there that requires the $50 (PDGA annual fee) as a monthly fee.
As for paying less to play, we are lucky.
Majority of our fields are free.
What money is collected goes to prizes, charities etc.
© 2015 Created by Terry "the Pirate" Calhoun.


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Tel: 604-898-1537 - Toll Free: 1-877-806-8046 Fax: 1-866-767-3704
PO Box 244, Brackendale, BC | V0N 1H0 | Map
Take a stroll along the banks of the Cheakamus, meander through woodland trails listening to the birds chattering, gaze at spectacular views of Mount Alpha from our hot tub, or curl up in your cozy riverside cabin listening to the sound of the Cheekye flowing by. With a fire pit, volleyball net, horseshoes and lots of greenspace for lawn games, you'll find plenty to do on your doorstep.
Each of our ten private cabins feature hardwood floors, vaulted ceilings, gas fireplaces, handmade pine furniture and en-suite shower rooms. With a double bed and a single day bed, they comfortably accommodate three adults. Cook your dinner beneath the stars with one of our communal barbecues, enjoy a fabulous breakfast on our cafe's sunny deck, or for more flexibility, book one of our kitchenette cabins.
Also, check out our Logger's Shack for a luxurious retreat, featuring wood fireplace, loft, full kitchen & full bathroom!
Sunwolf is Pet Friendly!
Situated at the confluence of the Cheakamus and Cheekye rivers, on 5 acres of grassy woodland, all of which is leash free, this is a pet heaven! There is an abundance of great walking and hiking right from our doorstep, not to mention the lovely rivers to cool hot paws in at the end of the day! We accept any pets – from Alsatian to Zebra – as long as they bring someone to pick up their mess! They are welcome inside the cabins, though it is understood that any damage will be paid for. There is a one-time fee of $15 CDN per pet to cover cleaning costs.
|Standard Cabin (From $100/night)
|Cabin w/ Kitchenette (From $110/night)


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June 30, 2009
U.S. Department of Energy Secretary Steven Chu announced on June 30 up to $32 million in Recovery Act funding to modernize the existing hydropower infrastructure in the U.S., increase efficiency, and reduce environmental impact. Today's announcement is designed to support the deployment of turbines and control technologies to increase power generation and environmental stewardship at existing non-federal hydroelectric facilities.
"There's no one solution to the energy crisis, but hydropower is clearly part of the solution and represents a major opportunity to create more clean energy jobs," said Secretary Chu. "Investing in our existing hydropower infrastructure will strengthen our economy, reduce pollution and help us toward energy independence."
Secretary Chu also noted another key benefit of hydropower: potential hydro energy can be stored behind dams and released when it is most needed. Therefore, improving our hydro infrastructure can help to increase the utilization and economic viability of intermittent renewable energy sources like wind and solar power. Secretary Chu is committed to further developing pumped storage technology to harness these advantages.
Today's funding opportunity announcement under the Recovery Act will be competitively awarded to a variety of non-federal hydropower projects that can be developed without significant modifications to dams and with a minimum of regulatory delay.
Projects will be selected in two areas:
Letters of intent are due July 22, 2009, and completed applications are due August 20, 2009. The complete Funding Opportunity Announcement can be viewed by selecting "Search Public Opportunities" on the FedConnect Web site, changing the search criteria to "reference number," and searching for reference number DE-FOA-0000120. Projects are expected to begin in fiscal year 2010.
Contacts | Web Site Policies |
U.S. Department of Energy | USA.gov


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Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
An attractive, older style chalet in a wonderful location at the top of the Nasserein nursery slopes. The lounge is bright and airy with wonderful views down the slopes and across the valley. Good intermediate skiers are able to ski back to the chalet and down to the lift in the morning, conditions permitting, there is a short off-piste section to be negotiated. The ski bus stop is just 300 metres away (2 minutes to Nasserein lifts or 5 minutes to St. Anton), or it is a 9 minute walk into Nasserein centre and a 20 minute walk into St. Anton.
Ground Floor
Dining Room with views, kitchen.Shared shower room, wc & separate wc.
Rooms 5 & 6: Austrian twins* (no washbasin).
First Floor
Entrance, ski rack, lounge area with views, small TV area (BBC World News and DVD Player).Shared bathroom, separate wc.
Room 1: Austrian twin* with shower, wc & terrace.Rooms 2 & 3: Austrian twins* with washbasin & terrace.Room 4: Austrian twin* with shower, wc & terrace.
*In certain locations, a twin is commonly accepted as referring to two separate mattresses and duvets contained in one large frame. Most hotels have rooms that will take an extra bed if required. These extra beds may be bunk beds, fold-away beds or sofa beds, but the suitability of these beds may depend on each individual. Where an extra bed is added this may limit the space available. Rooms with extra beds are still bookable for two person occupancy although, in this case, the hotelier may allocate a standard-sized twin bedded room without extra beds. Single rooms do not always match up either in size or facilities to twin bedded rooms, even when a supplement is paid.
Sleeps: 12 guests.
Bedroom facilities
"Free wine included worth over €100".
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 020 8544 7114 for prices for other travel
and room options for this property.
The price shown includes 7 nights accommodation,
with flights from Gatwick.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


text:
Kristen Stewart pictures and photos. Kristen Stewart portrays Bella Swan from Twilight, New Moon movie, Eclipse, and Breaking Dawn.
What did you think of Breaking Dawn 2?
View Results
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text:
From per adult
Delicious, creative cuisine and impeccable table art. Our chefs pull out all the stops to ensure you have a fabulous and entertaining meal.
This hillside restaurant with a view over the sea, marina and pool welcomes you for all your meals with a great variety of dishes from the buffet
There is a baby corner where parents can prepare meals for their little ones.
Available all day and evening (during bar opening hours) in all the bars in the Resort.
Drinks included(served by the glass and in the bars only):
Water, fruit juices, sodas, hot drinks, cocktails with and without alcohol, local and/or international spirits, wines.
Sweet and savoury snacks
Drinks not included
Champagne, VSOP and XO spirits, bottled and canned drinks (available in certain Resorts from vending machines and/or the Club Med boutique®), certain super-premium brands and bottled wines proposed à la carte in some of our restaurants and bars.
Close to the swimming pool, this bar is open during the day, with a vast pergola that allows you to make the most of the Corsican climate.
This functionality is only accessible to My Club Med ® members. Allows you to save your preferred Resorts
Existing Club Med customerACTIVATE YOUR PERSONAL SPACE
Not a Club Med customer yet.CREATE AN ACCOUNT


text:
Mercedes driver Lewis Hamilton is Britain's richest sportsman with a fortune of £68m...
Mercedes driver Lewis Hamilton is Britain's richest sportsman with a fortune of £68m.
In a year when Formula One drivers claimed the 1-2 on the The Sunday Times, Hamilton was firmly established in the number one position.
Adding £8m to his tally in the past year, Hamilton came in with £68m, five million better than former McLaren team-mate Jenson Button.
The Formula 1 duo edged Manchester United and England football player Wayne Rooney, who is worth £60m.
Basketball's Steve Nash was fourth on the list ahead of Manchester United's Rio Ferdinand.
The Sunday Times Rich List 2014
01. Lewis Hamilton (Motor racing): £68m
02. Jenson Button (Motor racing): £63m
03. Wayne Rooney (Football): £60m
04. Steve Nash (Basketball): £56m
05. Rio Ferdinand (Football): £44m
06. Andy Murray (Tennis): £40m
07. Steven Gerrard (Football): £37m
= Frank Lampard (Football): £37m
09. Luol Deng (Basketball): £36m
= Ryan Giggs (Football): £36m


text:
Nb: infants must be under the age of 2 and
children must be under the age of 12 at the time of
Large aparthotel "Eurotel". In a central position, south facing position. For shared use: garden, indoor pool (14 x 7 m, depth 100 - 260 cm). In the house: reception, restaurant, bar, breakfast room, sauna, lift, storage room for skis. Linen change weekly. Room cleaning weekly. Roofed, parking (in winter extra). Shop 50 m, shopping centre 30 m, restaurant 50 m, bus stop 20 m, railway station "Villars - Bretaye" 500 m, thermal baths "Lavey-les-Bains" 19 km. Sports harbour 25 km, golf course (18 hole) 7 km, indoor tennis centre, sports centre 800 m, mountain railway 500 m, ski lift 300 m, gondola lift 700 m, ski bus stop 20 m, ski school 500 m, children's ski school 800 m, ice field 1 km, children's playground 600 m. Free ski bus service to the ski region Villars. Inclosed swimming pool and sauna included in the price. 1-room apartment south facing position, comfortable furnishings: living/dining room with 2 beds, cable TV and radio. Kitchenette (2 hot plates, oven). Bath/WC. Balcony, south facing position. Terrace furniture. Partial view. 1 pet/ dog allowed. 1 extra bed can be requested. CHF 100/week/bed. Children from 0 to 8 years are free. The fridge is the mini bar and is therefore small. Please avoid frying food in the kitchen as this will set the fire alarm off.
Iglu acts as a travel agent for disclosed principals/tour operators, further details
of which will be made available at the time of booking. Your holiday contract will
be bound by the tour operators terms and conditions.
Prices are shown for a basic room or unit, can be subject to change and are indicative
until time of booking. Please call on 020 8544 7114 for prices for other travel
and room options for this property.
Prices shown are per person per week based on maximum occupancy. Descriptions and
quality ratings are provided by the Tour Operator (or one of the Tour Operators
where similar holidays are offered by more than one supplier). We reserve the right
to make minor adjustments to the description or rating based on staff and customer
feedback. For payments by credit card, a 2.5% credit card charge (4% for AMEX) will
be added to your invoice. If you pay by a UK issued debit card, there is no charge.
All bookings are subject to a £5 per person Passenger Admin Fee charged by Iglu.com.


text:
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Click here to select category and product to view product details
Benefit of registration;
- Registering your product streamlines the warranty claim process if you ever have a warranty claim.
View instruction documents for current and past Thule products.
You will be directed to the official Thule Trailers website. If you're not automatically redirected within 5 seconds, please click here.


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The reality that someone you love has such a devastating illness can trigger a range of emotions — including anger, fear, frustration and sadness. Conflicts are common as family members struggle to deal with the situation.
To minimize these conflicts, address the issues together.
Consider each family member's preferences, resources and abilities.
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text:
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Personalized Stainless Steel Cigar Cutter
Personalized Stainless Steel Cigar Cutter
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Product Description
The perfect gift for that cigar aficionado in the family is this personalized cigar cutter. The personalized stainless steel cigar cutter is an impressive gift to give to someone who likes a good cigar. The brass casing with satin silver finish gives the design of the cutter a very sleek look. The stainless steel single guillotine blade ensures you will get the perfect cut on your cigar every time. This gift is great to give to just about anyone, a father, son, boss, and just about anyone in between. The cigar cutter is appropriate for just about any occasion as well. This is the best cigar cutter because it can be monogrammed, the recipient's initials will be laser engraved on the casing of the blade. A thoughtful and elegant addition to an already very unique gift.
This stainless steel cigar cutter will make any cigar lover very appreciative. The custom accessory is the perfect gift to give someone who enjoys cigars. The size of the cigar cutter makes it perfect to be brought around with you anywhere, it has a light and well designed body. The cigar cutter measures 2 3/8" by 1 5/8". The single guillotine blade will cut up to a 60 ring gauge cigar.
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Personalize this gift with a name or initials.
May we also suggest the following gifts...
Silver Plated Guillotine Cigar Cutter
Personalized Aluminum Travel Humidor
Personalized Silver Cigarette Case
Personalized Stainless Steel Flask and Cigar Holder
Executive Cigar Humidor Box
Engraved Gunmetal Cigar Cutter
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Monogrammed Black Leather Cedar Lined 54 Gauge 3 Cigar Holder
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Uji Asamushi Sencha "Hana no Kaori"
(Sep 3, 2015)
Our price: $20.16
Uji Green Tea - Uji was an important stop along the road between Nara and Kyoto, and was the setting for the world's oldest novel, The Tale of Genji (源氏物語 Genji Monogatari). In order to get to either Kyoto or Nara, this bridge in Uji was crossed.
To the left you can see a copy of an original print of the famous bridge that crosses the Uji river, and next to it is the Tsuen tea shop. After 850 plus years of being in business, the Tsuen tea shop continues to operate at the same location and remains the oldest tea shop in Japan. To this day Uji remains an extremely important center for all things green tea in Japan and is known for it's high quality products. O-Cha.com is proud to carry a lineup of high quality Uji green teas and matcha, including many items from Tsuen.


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Paul Goodman Changed My Life
A portrait of writer Paul Goodman, who with his book "Growing Up Absurd" (1960) gave a voice to a generation of young people and helped define a New Left. He was an openly bisexual philosopher, poet, essayist, and pacifist whose work was essential to the emerging gay movement of the early 1970s. Privately, he lived his life with equal devotion to a wife and family he cherished. Here, we get an intimate look at his unapologetic lifestyle.
Cast: Paul Goodman
Produced by:
Directed by: Jonathan Lee
Written by:
Running time: 1hr 29min
Opens: Oct 19, 2011 Limited
|Theaters for Today
Pick a day
on this day.


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Club Muroc closure
Club Muroc will be closed through Sept. 9 for kitchen renovations.
Congressman hosts academy information night
Congressman Howard "Buck" McKeon is hosting a Service Academy Information Night 7 p.m., Sept. 12 at the College of the Canyons University Center.
Anyone aged 17-21 who is interested in attending one of the service academies and who lives in California's 25th Congressional District should plan on attending. This meeting is for academy classes starting in July 2013.
The service academies are: U.S. Naval Academy, Annapolis, Md., U.S. Military Academy, West Point, N.Y., U.S. Air Force Academy, Colorado Springs, Colo., U.S. Coast Guard Academy, New London, Conn., and the U.S. Merchant Marine Academy, Kings Point, N.Y.
For more information, call (661) 274-9688 or (661) 254-2111.
New School Liasion Officer
Christy McCoy is the new and full-time Edwards AFB School Liaison Officer.
She will have access to the firstname.lastname@example.com (soon to change to 412) as well as her personal email address email@example.com.
For more information, call (661) 277-3210.
Short notice deployment?
Are you deploying on short notice? The Base Legal Office is here to help. We offer legal assistance outside our normal hours for short notice deployers. If you need a will, power of attorney or other assistance, please stop by our office and we will get you situated with whatever documents you need.
For more information, contact the Base Legal Office at (661) 277-4310.
Save the date
Celebrate 65 Years of Transformation with the Air Force Ball at Edwards. The ball will be 6 p.m., Sept. 21 at Club Muroc. Ticket representatives and sales are coming soon.
Fraudulent check increase
In the past few weeks, the Base Legal Office have seen a rise in check scams.
Checks will come in the mail with a correct address and name, appear to be real with routing numbers, business names, watermarks and perforations. The checks can come from companies or be in the name of some sweepstake or lottery. Sometimes the teller will not be able to determine if it is fraudulent. The Legal Office warns not to deposit the check, as bank customers are responsible for the checks they deposit.
For more information, call (661) 277-4310.
Off-road vehicle requirements
The Air Force requires all operators of off-road motorcycles, three-wheelers and ATVs to successfully complete safety training before operating their vehicles on a military installation.
That means anyone who wants to ride those vehicles in an off-road vehicle area at Edwards must be able to show proof of the successful completion of training from groups such as the Specialty Vehicle Institute of America or the Motorcycle Safety Foundation.
If there are costs to complete this training, they must be paid by the person completing the training.
The following link will provide the required training through the SVIA online at no cost – www.atvsafety.org.


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Are you ready to begin an exciting adventure in the field of beauty? Then check out Marinello Schools of Beauty! At our Provo campus, we're proud to offer the following programs:
- Cosmetology/Barbering
- Esthetics (Skin Care)
- Master Esthetics with Laser Certification
- Nail Technology
You'll be on your way to a beautiful new career in only about a year's time!
Our educational approach combines technical instruction with salon experience to ensure that you'll become expert in hair-, skin-, and nail care. We offer flexible class schedules, as well as financial aid for those who qualify. Upon graduation, career placement assistance is available to help you find employment.
For more information, call 888-434-6989, or visit us today! We're located at the Cottontree Square business center, 2230 North University Parkway at West 2230 North Street.
Marinello Schools of Beauty has been defining beauty education since 1905 and operates more than 60 campuses nationwide. Marinello has provided thousands of graduates with Cosmetology education in Arizona, California, Connecticut, Kansas, Massachusetts, Nevada, Oregon and Utah.
For more information on graduation rates, median debt of students and other important information, visit the www.marinello/disclosure page to download the Marinello Schools of Beauty Gainful Employment Disclosures.


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Best of News
[UNVERIFIED CONTENT] Also known as the Galeb or Geleb, this tribe... News PhotoEthiopia,Horizontal,Horn of Africa,Indigenous Culture,Kenya,Lake Turkana,LifestylesPhotographer Anthony PapponeCollection: Moment anthony pappone[UNVERIFIED CONTENT] Also known as the Galeb or Geleb, this tribe lives just north of Kenya's Lake Turkana. Their neighboring tribe is the Turkana people. Cattle are used by the tribesman for meat, milk and clothing. Often Their cattle die from disease and drought. the Poorest Daasanech are the tribes in the Omo Valley.


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Satellite View Selection
21:30 AEST on Friday 4 September 2015 | Cloud/surface composite, Australia
Images from Japan Meteorological Agency satellite MTSAT via Bureau of Meteorology.
IDY28000 Australian Government Bureau of Meteorology Bureau National Operations Centre Satellite Notes for the 0000UTC chart on 5 September 2015 Issued at 11:30 am EST Saturday on 05 September 2015 A high over southeastern Australia is extending an onshore flow over Tasmania, Victoria and is generating low level cloud in the vicinity with patchy low cloud also visible along the New South Wales coast and southeast Queensland coast. A cold front has moved off the coast of Tasmania. Associated middle level cloud is visible over Tasman sea. A middle level cloud band associated with an upper trough is moving over southwest Western Australia. Remaining parts of the country are mostly clear due to the high extending a ridge over central Australia.


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Taking a cue from artists and their studios, Debbie Freeman cultivates her vintage collection with a sharply honed, deeply personal signature style. Independently, each of these tattered home accents, art pieces, and toys is arresting and uncommon. Collectively, they have the mark of a masterful eye—one seeking objects that inspire with raw, bohemian beauty. Enter the kingdom of Duchess D.
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horse.com > Halters & Leads > Cribbing & Grazing Muzzles > Item # BRK61
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Grazing Muzzle with Halter
The Grazing Muzzle with Halter helps control over-eating by limiting intake through the small opening at the bottom of the muzzle. The bottom is made out of rubber coupled with nickel-plated steel hardware.
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Nothing beats the look of real wood. Natural woods add eye appeal to any part of your home, but are especially important in highly visible outdoor decks, porches, and ramps. Of course, these structures will also need to conform to building standards so you and your family can enjoy them in comfort and safety.
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Five ways you can have fun this weekend:
Dear Dave,I�ve been following your plan, and I�d like to find a way to make a little more money on the side. Do you have any ideas for generating some passive income?TaiwanDear Taiwan,
Richard Sherman gave Tom Brady an earful and trolled him on Twitter a few years ago. Now the All-Pro cornerback says the star quarterback isn't really a choir boy.
Bloggers share simple ways to add major curb appeal to your home�even during the winter months!
Looking to upgrade your yoga studio? These are the best of the best the US has to offer!
Renowned businessman, CEO, mother, and health guru Maria Rodale on why being a size 2 "isn't on her to-do list."
Gideon is gone, but not forgotten.That was the thinking Criminal Minds executive producer...
Who kidnapped Liv?We'll find out "pretty quickly" when Scandal returns Thursday,
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800.26.003 - Lilley Spot chrome plated brass
Spot light in chrome plated brass, 350° turnable, 90° adjustable, with lampholder 12V B15d. Dimensions: width 66mm (= diameter ceiling plate) - height max 123mm. Suitable for lamp QR70 B15d 12V max 50W. Main power 12V AC. Use: indoor
- 814.26.002-LLilley spot on box LED weathered brass
- 800.26.002Lilley Spot weathered brass
- 800.26.004Lilley Spot dull nickel plated brass
- 814.26.002Lilley Spot on box weathered brass
- 814.26.003Lilley Spot on box chrome plated brass
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- 800.26.902Lilley Recessed Spot weathered brass
- 800.26.903Lilley Recessed Spot chrome plated brass
- 800.26.904Lilley Recessed Spot dull nickel plated brass


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JOINT BASE SAN ANTONIO-RANDOLPH, Texas (AFNS) — The Air Force has successfully upgraded and transferred the Military Personnel Data System to the Defense Information Systems Agency Defense Enterprise Computing Center, Air Force Personnel Center officials said March 25.
"We're pleased that the MilPDS upgrade took less time than anticipated, and we are well on our way to getting information updated in the system," said Joe Thele, the Air Force Personnel Operations Agency director. "The quick turn and successful upgrade is due to the meticulous planning and hard work of our Total Force team."
MilPDS is the primary records database for personnel data and actions that occur throughout every Airman's career. MilPDS is also used to initiate pay actions, maintain Air Force accountability and strength data and support a host of interactions with other Air Force and Department of Defense processes and systems that rely on personnel data.
AFPOA and Air Force Lifecycle Management Center teams worked closely with the Defense Manpower Data Center, AFPC, Air Force Reserve, Air National Guard, Air Force Space Command, and base personnel teams to develop a comprehensive plan to bring down the old personnel data system, upgrade it, and stand it back up. March 4, AFPC Commander Maj. Gen. A.J. Stewart hit the button to shut down MilPDS for what was expected to be 23 days. However, the upgrade was accomplished in 17 days.
Active-duty, Air National Guard and Air Force Reserve personnel agencies are working hand in hand with base force support squadrons and military personnel sections to update personnel data and transactions in MilPDS.
"This upgrade and transfer being accomplished in less time than expected is a testament to the strides we've made to work together for the good of all three components of the Total Air Force," Thele said.


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A great chicken salad entrée or side dish. Our fully cooked, skinless, diced chicken breast is wonderful when paired with a blend of seasoned white & wild rice, crunchy water chestnuts and celery, sweet mandarin oranges and a light balsamic vinaigrette dressing.
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The Bonnaroo audience is a musically open-minded one, but the festival organizers wisely realize that we all have our limits. If there's a certain performer on one stage that isn't your bag, you'll likely find another act performing just around the corner that's more your speed.
Not digging the classic country stylings of Loretta Lynn? Why not get into the groove with Bootsy Collins & the Funk University? Can't bear to listen to Wiz Khalifa's "Black and Yellow" one more time? Soothe your senses with acclaimed neo-folkies Mumford & Sons. Of course, it's not all smooth sailing. Surely we're not the only ones torn by Sharon Van Etten and Jessica Lea Mayfield hitting stages at the exact same time, or Lil Wayne and Big Boi hosting near-simultaneous late-night throwdowns.
Click the photo above to see which groups will be squaring off this year in Manchester, as Bonnaroo 2011 kicks off Thursday, June 9 and runs through Sunday, June 12.
Keep up with our reports from the festival: Tennessean.com/Bonnaroo. (Follow us on Twitter @tuneinmusiccity, too.)


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Late-stage results from the probe development effort to identify antagonists of OPRK1: fluorescence-based cell-based dose response assay, Set 2.
Name: Late-stage results from the probe development effort to identify antagonists of OPRK1: fluorescence-based cell-based dose response assay, Set 2. ..more
BioActive Compound: 1
Related Experiments
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC)
Affiliation: The Scripps Research Institute, TSRI
Assay Provider: Lakshmi A. Devi, Mount Sinai School of Medicine
Network: Molecular Library Probe Production Centers Network (MLPCN)
Grant Proposal Number: R03NS053751
Grant Proposal PI: Lakshmi A. Devi, Mount Sinai School of Medicine
External Assay ID: OPRK1_ANT_FRET_384_4XIC50_SET2
Name: Late-stage results from the probe development effort to identify antagonists of OPRK1: fluorescence-based cell-based dose response assay, Set 2.
Potent and selective OPRK antagonists will be useful for studying the mechanisms involved in OPRK-mediated analgesia and may have therapeutic value as novel analgesics with an improved side effect profile to currently available drugs. Studies have identified a role for dynorphin and OPRK stimulation in neuropathic pain (1). The dynorphins act as endogenous agonists at the opioid receptors, including OPRK (2), and the increased dynorphin expression in neuropathic pain also leads to a sustained activation of OPRK (1, 3). The mechanisms and neural circuits in OPRK-mediated analgesia are active areas of study; it is hoped those studies will assist in the development of novel analgesics that bypass OPRK-mediated depression (4-5). A role for dynorphin/OPRK in modulating drug addiction has been proposed (for review, see (6-7)). The function of dynorphin/OPRK systems in addiction appears to be diverse, and may modulate drug-seeking behavior depending on factors such as drug history, pattern of intake, and stress (for review, see (6)). The availability of potent and selective OPRK ligands may help unravel these mechanisms, as well as prove to be of therapeutic utility. Evidence from preclinical studies indicates that the dynorphin/OPRK system may be dysregulated in affective psychiatric disorders (for review, see (6, 8)). However, solid evidence from clinical studies is lacking. There is increasing evidence for a potential involvement of dynorphin/OPRK in schizophrenia; OPRK agonists appear to induce symptoms in humans and animals that are present in schizophrenia (8-10). Thus, the availability of new research tools such as potent and selective OPRK antagonists will facilitate understanding the physiological and pathophysiological mechanisms of dynorphin/OPRK systems and their roles in psychiatric disease in humans.
1. Xu, M., et al., Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. J Neurosci, 2004. 24(19): p. 4576-84.
2. Chavkin, C., I.F. James, and A. Goldstein, Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science, 1982. 215(4531): p. 413-5.
3. Xu, M., et al., Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci, 2007. 27(10): p. 2570-81.
4. Al-Hasani, R. and M.R. Bruchas, Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology, 2011. 115(6): p. 1363-81.
5. Muschamp, J.W., A. Van't Veer, and W.A. Carlezon, Jr., Tracking down the molecular substrates of stress: new roles for p38alpha MAPK and kappa-opioid receptors. Neuron, 2011. 71(3): p. 383-5.
6. Tejeda, H.A., T.S. Shippenberg, and R. Henriksson, The dynorphin/kappa-opioid receptor system and its role in psychiatric disorders. Cell Mol Life Sci, 2012. 69(6): p. 857-96.
7. Yoo, J.H., I. Kitchen, and A. Bailey, The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us? Br J Pharmacol, 2012. 166(7): p. 1993-2014.
8. Schwarzer, C., 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases. Pharmacol Ther, 2009. 123(3): p. 353-70.
9. Bortolato, M. and M.V. Solbrig, The price of seizure control: dynorphins in interictal and postictal psychosis. Psychiatry Res, 2007. 151(1-2): p. 139-43.
10. Sheffler, D.J. and B.L. Roth, Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. Trends Pharmacol Sci, 2003. 24(3): p. 107-9.
Late stage, late stage AID, OPRK1, kappa, opioid, receptor, GPCR, beta-arrestin, U2OS, Tango trade mark, beta-lactamase, FRET, FRET-enabled substrate, TEV, TEV protease, beta-arrestin, EC80 challenge, SNC80, antagonist, inhibitor, inhibit, pain, analgesic, dynorphin, neuropathic pain, drug addiction, addiction, 384, Scripps, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN.
Assay Overview:
The purpose of this assay is to confirm the potency of test synthesized compounds. This assay uses Tango OPRK1-bla U2OS cells which express OPRK1 linked to a GAL4-VP16 transcription factor via a TEV protease site. The cells also express a Beta-arrestin/TEV protease fusion protein and a Beta-lactamase (BLA) reporter gene under the control of a UAS response element. Stimulation of the OPRK1 receptor by agonist causes migration of the Beta-arrestin fusion protein to the GPCR, and through proteolysis liberates GAL4-VP16 from the receptor. The liberated VP16-GAL4 migrates to the nucleus, where it induces transcription of the BLA gene. BLA expression is monitored by measuring fluorescence resonance energy transfer (FRET) of a cleavable, fluorogenic, cell-permeable BLA substrate. As designed, test compounds that act as OPRK1 antagonists will inhibit agonist activation and migration of the fusion protein, thus preventing proteolysis of GAL4-VP16 and BLA transcription, leading to no increase in well FRET. Compounds were tested in either quadulplicat or octuplet using a 12-point, 1:3 dilution series starting at a nominal concentration of 10 uM.
Protocol Summary:
The Tango OPRK1-U20S dividing cell line was routinely cultured in 150 mm dishes at 37 C, 5% CO2 and 95% relative humidity (RH). The growth medium consisted of McCoys 5A Media supplemented with 10% v/v dialyzed fetal bovine serum, 25 mM HEPES, 0.1 mM non-essential amino acids, 1 mM sodium pyruvate, and 1X antibiotic mix (penicillin streptomycin). On day 1 of the assay, 16,000 cells in 10 uL of assay media (DMEM-Glutamax with sodium pyruvate, 10% fetal bovine serum stripped with charcoal-dextran, 25 mM HEPES, 0.1 mM non-essential amino acids, and antibiotic mix (penicillin streptomycin) were seeded into each well of a 384-well plate. On Day 2, 50 nl of test compound in DMSO were added to the appropriate wells and plates were incubated for 30 minutes at 37 C, 5% CO2 and 95% RH. Next, 0.6 uL of 111 nM U50488 OPRK1 Agonist (EC80 Challenge; final concentration 6 nM) or DMSO in assay medium was added to appropriate wells and incubated 4 hours at 37 C, 5% CO2 and 95% RH. 2.5 uL of LiveBLazer trade mark FRET B/G (CCF4-AM) loading mix (prepared according to manufacturer's instructions; 6 uL solution A, 60 uL Solution B, 904 uL Solution C, and 30 uL Solution D) were added to each well, and plates incubated at room temperature in the dark for 2 hours. Well fluorescence was measured on Perkin Elmer's Envision using an Excitation filter 409 nm, Emission filters at 460 nm and 590 nm, bottom read.
Percent Inhibition was calculated from the median ratio as follows:
%_Inhibition = 1 - ( ( FI_Test_Compound - Median_FI_HighControl ) / ( Median_FI_Low_Control - Median_FI_High_Control ) ) * 100
FI is defined as Fluorescence Intensity at 460 nm/Fluorescence Intensity at 530 nm.
Test_Compound is defined as wells containing test compound.
Low_Control (0% inhibition) is defined as wells containing U50488 EC80 challenge
High Control (100% inhibition) is defined as wells containing DMSO.
For each test compound, percent inhibition was plotted against the log of the compound concentration. A three parameter equation describing a sigmoidal dose-response curve was then fitted using GraphPad Prism (GraphPad Software Inc) normalized from 0 to 100 for each assay. The software-generated IC50 values were reported. In cases where the highest concentration tested (i.e. 50 uM) did not result in greater than 50% inhibition, the IC50 was determined manually as greater than 50 uM.
PubChem Activity Outcome and Score:
Compounds with an IC50 of 10 uM or less were considered active. Compounds with an IC50 of greater than 10 uM were considered inactive.
Any compound with a percent activity value < 50% at all test concentrations was assigned an activity score of zero. Any compound with a percent activity value >= 50% at any test concentration was assigned an activity score greater than zero.
Activity score was then ranked by the potency of the compounds with fitted curves, with the most potent compounds assigned the highest activity scores.
The PubChem Activity Score range for active compounds is 100-100. There are no inactive compounds.
List of Reagents:
Tango trade mark OPRK1-bla U20S Cells (Invitrogen K1576)
McCoy's 5A Medium, (Invitrogen, part 16600-082)
Dialyzed Fetal Bovine Serum, (Invitrogen, part 26400-036)
Non Essential Amino Acids 100X (Invitrogen, part 11140-050)
HEPES (pH 7.3) 1M, (Invitrogen, part 15630-080)
Sodium Pyruvate 100X (Invitrogen, part 11360-070)
Penicillin Streptomycin, (Invitrogen, part 15640)
Trypsin 0.25% EDTA (Invitrogen, part 25200056)
DPBS without Calcium /Magnesium (Invitrogen, part 14190-136)
DMEM, High Glucose,GlutaMAX (Invitrogen, part 10569-010)
Fetal Bovine Serum, Charcoal Stripped (Invitrogen, part 12676-011)
DMSO Dry (Sigma, part D2650)
U50488 OPRK1 Agonist MW410.29 (Tocris 67198-19-0)
GNTI dihydrochloride OPRK1 Antagonist MW571.5 (Tocris 1282)
Nor-Binaltorphimine dihydrochloride MW770.75 (Tocris 0347)
384 black low profile, clear bottom, low volume plate (Greiner, part 788092)
Low profile plate lids (Greiner, part 656190)
LiveBLAzer trade mark-FRET/BG Loading Mix (Invitrogen, part K1030
This assay was performed by the SRIMSC with powder samples of synthesized test compounds.
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay: CurveFit [1]: Equation: = [Baseline Response] + ( [Maximal Response] - [Baseline Response] ) / ( 1 + 10 ^ ( ( [LogEC50] - Log( [Concentration] * 10^-6) ) * [Hill Slope] ) )
Assay: Dictionary: Version: 0.1
From PubChem:
Assay Format: Cell-based
Assay Cell Type: U-2 OS
From ChEMBL:
Assay Format: Cell-based
Assay Type: Functional
Result Definitions
* Activity Concentration. ** Test Concentration.
Additional Information
Grant Number: R03NS053751
Data Table (Concise)


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Steiner 10 x 30 Safari UltraSharp CF Binoculars brings distant objects up close. The vivid display and the clarity of high-contrast optics offer top performance levels for all types of observing.
With the new UltraSharp optics concept applied to the successful Safari series, Steiner sets a new standard in the performance of compact outdoor binoculars.
Amazing clarity even into the edge zones, unbelievable color brilliance even under difficult lighting conditions and vivid images are the features of the newly developed high-contrast optics.
The highlight of the Safari UltraSharp 10 x 30 is the amazingly vivid image they offer, with an extraordinary depth of focus and lifelike colors. The original Steiner Safari models have been tried and tested for decades and millions sold.
COLOR: Black


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Chemical Review Manager: James Parker (firstname.lastname@example.com), 703-306-0469
Press Contact: Molly Hooven (email@example.com), 202-564-23135/14/2010: EPA Plans New Use Limitations on Carbaryl, Carbofuran, and Methomyl to Protect Salmon and Steelhead in California, Idaho, Oregon, and Washington (PDF) (20 pp, 888.73k, about PDF)
Docket Information
- See docket EPA-HQ-OPP-2005-0162 for documents related to EPA's review of this pesticide.
- See docket EPA-HQ-OPP-2007-1088 for documents related to the Scientific Advisory Panel's review of the carbofuran NOIC.
- Risk assessment and related documents for this pesticide have been removed to Special Docket EPA-HQ-OPP-2007-0151.
- Visit Regulations.gov for information about other pesticide reregistration chemicals.
Carbofuran NOIC
- Carbofuran Cancellation Process, June 2011
Decision Documents
- Interim Reregistration Eligibility Decision (IRED)(PDF) - August 2006 (44 pp, 393k, About PDF)
- IRED Fact Sheet
Federal Register Correction
- Technical Correction Issued to October 29, 2008 Federal Register Notice. EPA's October 29, 2008, Federal Register (FR) notice announcing the Agency's receipt of pesticide registrants' requests to amend their registrations to delete certain uses includes some errors. EPA has received a request from the carbofuran registrant to voluntarily amend their carbofuran registrations to delete certain uses. However, the October 29 FR notice includes errors about some of those uses and the time frame for submitting comments. EPA published a Technical Correction in the Federal Register on November 6, 2008, removing the carbofuran registrations from the October 29 notice. The Agency is publishing a Federal Register notice on December 19, 2008, announcing the requested amendments to delete carbofuran uses. This FR notice includes the correct uses and correct time frame for providing comments. For additional information, please contact Jude Andreasen, firstname.lastname@example.com, (703) 308-9342.
Federal Register Notices
- Carbofuran Order Denying FMC's Objections and Requests for Hearing; Final Rule (November 18, 2009)
- Carbofuran; Final Tolerance Revocations [May 15, 2009].
- Carbofuran; Product Cancellation Order [March 18, 2009]
- Carbofuran; Notice of Receipt of Request to Voluntarily Cancel Carbofuran Pesticide Registrations [December 19, 2008], comments accepted through January 20, 2009.
- Notice of Receipt of Requests for Amendments to Delete Uses in Certain Pesticide Registrations; Technical Correction [November 6, 2008]
- Carbofuran; Notice of Availability of Revised Surface Water Exposure Assessment [August 29, 2008]
- Carbofuran; Proposed Tolerance Revocations [July 31, 2008], comment period closed on September 30, 2008
- FIFRA Scientific Advisory Panel; Notice of Public Meeting - Notice of Intent to Cancel to be held February 5-8, 2008
- Carbofuran; Interim Reregistration Eligibility Decision; Extension of Comment Period [October 25, 2006], extended comment period closed on November 30, 2006
- Carbofuran; Interim Reregistration Eligibility Decision; Notice of Availability [August 30, 2006], comment period closed on October 30, 2006
- Carbofuran Revised Risk Assessments; Notice of Availability and Solicitation of Risk Reduction Options [March 22, 2006], comment period closed on May 22, 2006
- Carbofuran; Risk Assessment Notice of Availability [September 14, 2005], comment period closed on November 14, 2005
- Carbofuran Risk Assessment; Notice of Availability [June 24, 2005], comment period closed on August 23, 2005


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ADHD familial loading and abnormal EEG alpha asymmetry in children with ADHD.. Journal of psychiatric research. 44(9):605-15. Abstract. 2010.
Atypical alpha asymmetry in adults with ADHD.. Neuropsychologia. 47(10):2082-8. Abstract. 2009.
Atypical EEG beta asymmetry in adults with ADHD.. Neuropsychologia. 48(12):3532-9. Abstract. 2010.
Cortical activity patterns in ADHD during arousal, activation and sustained attention.. Neuropsychologia. 47(10):2114-9. Abstract. 2009.
Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder.. Journal of the American Academy of Child and Adolescent Psychiatry. 49(4):368-77. Abstract. 2010.
Rethinking a right hemisphere deficit in ADHD.. Journal of attention disorders. 13(1):3-17. Abstract. 2009.


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I opened my onion rack lately to find onions that had sprouted several-inch-long green roots... It made me extremely queasy and I threw them out. But I was wondering - would it be safe to eat them / cook with them?
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Sure, but the rest of the onion gets mushy and unpalatable after they've grown for a bit. Some people eat the sprouts; they have a lot of protein, so they're popular with vegans and other protein challenged groups.
The roots aren't usually very green- they're white.
The part of the sprouts that is green is call... wait for it... Green onions.
You can just eat the sprouts and don't bother with the spent bulb.
Absolutely! They can be quite strong though. I would recommend cutting them thinly. I just used some as a garnish on my miso soup. They add just enough onion flavor and it looks nice.