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Gallery: Adrian Smith + Gordon Gill Will Design Tallest Building in the...
Almost a year after its opening in 2010, only 75 of Burj Khalifa's 900 luxury apartments were occupied. But this hasn't deterred Saudi billionaire Prince Alwaleed bin Talal from signing a contract to build the new Kingdom Tower in the city of Jeddah on the Red Sea. The new tower will reach over 1,000 meters, with the actual height remaining a secret until completion (the Burj Khalifa reaches a paltry, in comparison, 828 metres).
The Kingdom Tower will be home to a Four Seasons Hotel, luxury condos, luxury office space and "the world's highest observatory." Fifty-nine elevators and 12 escalators will service the tower and floor 157 will host a sky terrace, accessible to the penthouse. The tower will also have some green features such as a high performance exerior wall to minimize thermal loads and the need for interior cooling. In addition, strategic exterior pockets were designed to create shade for the same reason, and to cool outdoor terraces naturally. Still, this is yet another Middle Eastern project that we think is seriously dubious.
+ Adrian Smith and Gordon Gill Architects
Image ©Leandro Ciuffo
10 Comments
August 13, 2011 at 2:35 pm
And how useful are the top 20 or so floors? It may be very high, but at some point a distinction should be made between usable space and decorative spire. It's the King's money, so he can do it, but there are so many more humane things to do with the money that a building like this shouldn't even come into the discussion.
August 8, 2011 at 8:55 am
At least they've provided a nice deck for people to jump from.
On a different note, the Burj Khalifa looks better. The UAE will build a larger tower.
August 8, 2011 at 5:04 am
I'm a muslim, not very holy, but if not mistaken I was taught that one of the signs the end of days is coming is that man starts to compete and takes pride in building taller and taller buildings. So I'm not sure where arab stands. Religious, or not religious?
Note on the 4th photo, I have to pay a lot to stay there and I still have to take 300 steps of stairs? lol
Also the 5th photo looks like the Enterprise just crashed into it.
August 5, 2011 at 4:01 pm
Learning lessons from Dubai…
If ever there was an urban area anywhere on Earth that epitomized the excesses of the boom years between 2002 and 2007, it has to be Dubai. A sign that this large-scale land development extravaganza was veering to unsustainable excess should have been Dubai's decision to erect a 200-story building that would make it the world's tallest structure. Other telltale signs should have been Dubai's determination to build the world's largest man-made artificial islands as well as a major ski resort in the desert – all developed with dwindling oil reserves, and without a source of sustainable food, fresh water or energy production for its burgeoning class-based society.
Sustainable Land Development Initiative
August 5, 2011 at 9:16 am
Or they are motivated by ego. I think that's more likely in this case, rather than "heart."


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Bromwich Wood Local Nature Reserve
Bromwich Wood Local Nature Reserve
Site name: Bromwich Wood
Grid Reference: SO998811
Ward: Bartley Green
Vice-county: Worcestershire
Planning Authority: Birmingham City Council
Bromwich Wood lies immediately northeast of Bartley Reservoir, adjacent to Scotland Lane. The county boundary with Worcestershire runs along two edges of the site. The boundary along the south west edge is marked by a dry ditch and bank.
Summary Description:
A little over 3ha of ancient semi-natural woodland. Pedunculate oak is the dominant species, although in some areas wild cherry is abundant. Surrounding land-use consists of a housing estate to the north, amenity grassland to the north-east and improved, grazed grassland to the west and south-west.
Site Status:
The site was declared a Local Nature Reserve on 20 September 1991.
Ancient semi natural Woodland (ASNW) and SINC (Site of Importance for Nature Conservation).
The site also falls within an area identified as Green Belt.


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Solo stars and bands certainly shined at the Ryman Auditorium on Wednesday night for the Americana Music Honors & Awards show — but it was a particularly good night to be a duo.
More than half of the top prizes at the 12th annual awards show — recognizing musicians inspired by American folk, country, blues, bluegrass, gospel and rock 'n' roll — went to two musical pairs with local ties. Revered Nashville songsmiths Emmylou Harris and Rodney Crowell took home duo/group and album of the year honors, while roots-rock newcomers Shovels & Rope —featuring Nashville native Cary Ann Hearst – won emerging artist and song of the year awards.
Though they've been working together for decades, Harris and Crowell's winning "Old Yellow Moon" was their first album as a duo. Speaking before the show, Crowell said the recognition from the Americana Music Association "means that we're still able to do what we started doing, and I think better. We're still standing."


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CORRECTION: An earlier version of this story mischaracterized the Center on Budget and Policy Priorities' budget analysis. The center's assumptions on deficit reduction include discretionary-spending cuts enacted during 2011.
The first presidential debate between President Obama and Mitt Romney on Wednesday night in Denver covered topics ranging from taxes to health care to job creation. Here is a look at some of their statements and how firmly they are grounded in fact.
Romney on health care spending:
Romney claimed that middle-income Americans are spending $2,500 more for health care now than they did when Obama took office in 2008. While Americans are spending more for their insurance and overall health spending since 2008, the difference is closer to $1,000, not $2,500. According to the Kaiser Family Foundation, the average employee purchasing family health insurance in 2012 paid $4,316 for insurance, just under $1,000 more than what they paid for insurance in 2008. Total per capita health expenditures had about the same $1,000 spread between 2008 and 2012, according to the Centers for Medicare and Medicaid Services. In 2008, CMS found Americans spent $7,910 per capita on health care; in 2012, they are estimated to spend $8,952.
Obama on Simpson-Bowles:
Obama, answering a challenge from Romney, said that he did take an adjusted version of the Simpson-Bowles deficit-reduction framework to Congress, and that he has proposed $4 trillion in deficit reduction. Not quite.
After the Simpson-Bowles commission failed to get the necessary votes needed to introduce its plan in December 2010, the White House looked the other way. The commission's plan would have reduced deficits by $4 trillion over 10 years through a combination of discretionary-spending cuts, broad tax reform, and entitlement savings.
Obama said his own proposals would also reduce the 10-year deficit by $4 trillion, an assertion that has been challenged by some budget experts as overly optimistic.
The president takes his number from the Center on Budget and Policy Priorities, which includes in its calculations cuts in discretionary spending already enacted into law during 2011.
Romney on "Obamacare's" Medicare board:
Romney's claim that Obama's health reform law includes a Medicare board that can "tell people ultimately what kind of treatments they can have" was one of the biggest whoppers of the night. It's a line that Republicans used during debate on the health reform law, when they regularly and inaccurately called the Medicare spending board a "death panel."
Under the Affordable Care Act, the Medicare board would have the job of keeping Medicare spending within a specific target: gross domestic product plus 1 percent by 2020. The board, which would be appointed by the president and approved by the Senate, is explicitly restricted from directly cutting Medicare benefits. In other words, they must cut hospital, doctor, and nursing-home payment rates, and they are not allowed to restrict what kinds of treatments those providers can offer to treat seniors.
Obama on Romney's tax plan:
The two candidates spent the first part of the debate squabbling over taxes, running roughshod over moderator Jim Lehrer to trade barbs over the finer points of Romney's plan. Obama criticized the plan early on, repeating the theme that Romney wants to raise taxes on the middle class in order to preserve cuts for the wealthy.
Obama's claim stems from a much-publicized Tax Policy Center analysis of Romney's framework, which found that a 20 percent across-the-board reduction in marginal personal income-tax rates couldn't be achieved without ridding the tax code of some tax expenditures that help the middle class. Roughly $1.1 trillion in revenue is lost to deductions and credits each year, with about 90 percent of that money going to the top 20 deductions--including widely popular items like the employer-provided health-insurance deduction and the mortgage-interest deduction.
The only top deduction that almost exclusively benefits the wealthy is the preferential rate for capital gains--and Romney has said he will preserve existing incentives for investment. The $17,000 cap on deductions Romney floated earlier this week would hit the wealthiest the hardest--in part because the wealthy are more likely to use deductions, as The Washington Post notes in its analysis--but the recouped funds would not be high enough to make up for the revenue lost by the sweeping rate reduction.
Romney on new business start-ups:
In the first question of the debate, Obama and Romney were asked to spell out the differences between their job-creation plans. According to Romney, small businesses create jobs--and new business start-ups are at a 30-year low.
Fact-checking website PolitiFact looked into this claim when House Speaker John Boehner made it in March, rating it "true." PolitiFact quotes Scott Shane, chairman of the economics department and professor of entrepreneurial studies at Case Western Reserve University:
"Using data from the Census Bureau and U.S. Small Business Administration, Shane found that the per capita rate of new employer business formation in 2009 (the most recent year available) was 1.32 per thousand people--'an astonishing 51.4 percent of the rate in 1977,' he said. 'That is, Americans are starting new businesses with employees at half the rate they did 30 years ago.' "
Romney on gas prices:
Romney said gas prices have doubled under Obama. That's true, Slate reported in April, and has become an oft-repeated criticism of the incumbent from the GOP.


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Country singer/songwriter Kip Moore and country songwriter Dan Couch celebrated their first No. 1 song — the two-week chart-topper "Somethin' 'Bout a Truck" — with a rooftop party at BMI last week.
"This is what you set out to do as a songwriter, to hopefully get the chance to write hits," Moore said before the party. "We love to write, but you get so used to it not happening that when it finally does, it's a hard thing to wrap your head around. To be in this place is life-changing for sure."
After the party kicked off, Moore and Couch got on stage to say their thank yous and got choked up while telling the crowd about their journey.
"I feel really really lucky to be able to do this today," Couch said. "My wife always believed we could be here today. When we moved here I asked my wife for five years. She gave me two five-year extensions and then some."
Moore got teary-eyed while acknowledging his father who passed away last year.
"I want to thank my dad for telling me to stick with it," he said. "I know he's up there watching... Maybe the next time I can cruise through this, but I think this is the first time it's hit me."


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Section 26a of the TVA Act
TVA's jurisdiction under Section 26a of the TVA Act is implemented through Section 26a regulations (18 C.F.R. part 1304). To view the Main Index of the Section 26a regulations click here. TVA also adopts guidance for consistent implementation of Section 26a regulations. This guidance can be viewed here. For additional assistance in interpreting the Section 26a regulations and guidance contact your local regional watershed office.
Where do Section 26a regulations apply?
Section 26a regulation applies to both the location of construction projects and the types of activities carried out.
Location. The regulations apply to anything built across, along, or in the Tennessee River or any of its tributaries. A tributary is any watercourse whose contents, if not obstructed, diverted, or consumed, will ultimately flow into the Tennessee River. TVAs jurisdiction thus extends to the limits of the Tennessee River watershed. Along regulated rivers (tailwaters) and TVA reservoirs, that jurisdiction applies to the limits of the 500-year floodplain or to the upper limits of TVA flowage rights, whichever is higher. Along off-reservoir, unregulated streams and rivers, jurisdiction is typically applied to the limits of the 100-year floodplain.
Types of construction projects. With regard to the range of construction and development activities along the shoreline, Section 26a regulation is limited to plans for the construction of obstructions affecting navigation, flood control, or public lands. An obstruction is any man-made physical condition that during its continuance after completion impounds, checks, hinders, restricts, retards, diverts, or otherwise interferes with the movement of water or of objects on or in the water.
See Minor Construction Projects or Major Construction Projects for the types of construction projects that do require permits.
What types of construction projects do not require permits?
Certain activities within or along the Tennessee River are not considered obstructions and therefore do not require a TVA Section 26a permit if they are conducted on privately owned land. Activities may still require local, state, or federal permits. See list of activities below.
Please note, however, that permission must be obtained from TVA before conducting any activities on TVA land. If you are planning an activity on TVA land, contact your local regional watershed office first.
- Removal of materials such as trees, tree stumps, brush, or sand and gravel from a streambed is not construction of an obstruction unless the material removed is piled in or along the stream, river, or reservoir in such a way as to create an obstruction.
- Excavation (dredging) of a new channel or enlargement of an existing channel is not construction of an obstruction unless it involves blocking, restricting, or draining the old channel.
- Excavation of a trench for a submarine sewer, telephone, or other utility line, in which the trench is backfilled to the original contour and is located outside the area of a marked navigation channel, does not create an obstruction. (TVA approval is required for all utilities buried in or under marked navigation channels.)
- Construction on, over, or along temporary, intermittent, seasonal, or wet-weather streams or drainages does not constitute an obstruction.
- Discharges into the Tennessee River System are not obstructions unless they are made through or by an obstruction (outfall pipe, etc.) subject to TVA approval.
- Replacement of culverts of same or greater hydraulic capacity, creating no new or additional obstruction, and within the same highway alignment are not new obstructions and are to be considered maintenance activity.
- Replacement of bridges of the same or greater hydraulic capacity, creating no new or additional obstruction, and within the same highway alignment are not new obstructions and are to be considered maintenance activity.
- Directional boring under streams or rivers for the installation of utilities or pipelines where no new obstructions are permanently placed within the floodplain are not considered obstructions.


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In 2012, the ASPCA Animal Poison Control Center (APCC) in Urbana, Illinois, handled more than 180,000 cases about pets possibly exposed to poisonous substances—and some breeds seemed to make up a lot more of those calls than others.
Nearly 14,000 of APCC's 2012 calls were from worried pet parents of Labradors. Domestic shorthair cats were involved in approximately 10,000 cases (the second-most popular breed involved in APCC calls). Mixed-breed dogs (8,000 cases), Chihuahuas (4,833 cases), Golden Retrievers (4,819 cases) and Yorkshire Terriers (3,800 cases) rounded out the top six.
No matter what kind of pets they had, thousands of pet parents called us about the same products last year. Here were the top five poisons that caused pet parents to call APCC for help in 2012:
1. Prescription Human Medications
APCC handled 25,000 cases regarding human prescription medications in 2012. The top three types of medications that animals were exposed to were: heart medications (blood pressure pills), antidepressants and pain medications (opioids and prescription non-steroidal anti-inflammatory drugs).
2. Insecticides
While just 11% of all calls to the APCC are about insecticides, more than 50% of the calls to APCC involving cats pertain to felines exposed to insecticides.
3. Over-the-Counter Human Medications
This group contains acetaminophen, ibuprofen and naproxen as well as herbal and nutraceutical products (fish oil, joint supplements).
4. Veterinary Products and Medications
Veterinary products made up nearly 6% of APCC's case volume for 2012. Both OTC and prescription veterinary products are included in this group. Watch out for flavored tablets!
5. Household Products
APCC fielded more than 10,000 calls about household products in 2012. Household toxins can range from fire logs to cleaning products.
For numbers six through 10, check out the full list of the top poisons of 2012.
And remember: If you have any reason to suspect your pet has ingested something toxic, please contact your veterinarian or the Animal Poison Control Center's 24-hour hotline at (888) 426-4435.


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text: Dispute Resolution Institute Educating you to be a successful creative agent of conflict resolution at home and abroad Upcoming Event Responding Effectively to Conflict with Opening Remarks from Robert A. Baruch Bush, author of The Promise of Mediation (by video conference).September 20-21, 2015 | 9:00 a.m. - 5:00 p.m. | 112 Anderson Center, Hamline University Campus, St Paul MN | 13 CLE hours applied for | Learn More For the 15th consecutive year Hamline's Dispute Resolution Institute is ranked in the top 5 dispute resolution programs in nation by U.S. News & World Report. In a world drawn ever closer by globalization, yet still fractured by historical and cultural division, evolution in conflict resolution management is critical. Thus, our Dispute Resolution Institute teaches you mediation because it provides a unique perspective on mutual understanding and creative problem-solving. We teach you the art of negotiation because it is central to both making and saving deals. We teach you arbitration because it is the global forum of choice for business. We offer a window into new ways of conceptualizing and delivering justice, ranging from the challenge of implementing the healing focus of restorative justice practices to the practicalities of online dispute resolution. We encourage you to actively explore questions of professional identity so you can seek the satisfaction that comes from a close connection between your work as conflict resolvers and your most deeply held values. And, we have made a commitment to explore all of these subjects and themes in international contexts out of the conviction that it is critical for you to push the boundaries of your own comfort level through deliberate exposure to different cultures and legal systems. Our Dispute Resolution Institute (DRI) offers rigorous academic discourse, hands-on simulation experience, and cross-disciplinary examination of conflict theory, advocacy, and problem-solving in domestic and study abroad courses to challenge you and prepare you for a bright future. We are also proud to have been affiliated with the Mediation Center since 1998. Master's degree and certificates provide opportunities to broaden your conflict resolution and legal education Our Master in the Study of Law and our certificates help you gain, or expand upon, your dispute resolution knowledge and skills. A DRI faculty advisor helps you with course planning and practice perspectives based on your areas of interest. Master in the Study of Law (MSL): 30-credit master's degree with conflict resolution and practical problem-solving at its core Dispute Resolution (CDR): 14-credit certificate program for non-JD students Advocacy and Problem-Solving (CAPS): 22-credit certificate program for Hamline JD students International Business Negotiation: 6-credit certificate program for law and business students, as well as practicing lawyers and business professionals Global Arbitration Law and Practice (National and Trans-border Perspectives): 6-credit certificate program for law students and practicing lawyers. Course availability All certificate courses are offered during the Summer Institute and January Term, and through study abroad programs in London and Jerusalem.


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Raise a glass with us! Harrah's Cherokee is now serving alcohol!
The thrill of playing at Harrah's Cherokee just got better! Now enjoy beer, wine, and mixed drinks served while you are playing your favorite game!
All alcohol sales on the casino floor will be cash only and sold Monday - Saturday, 7am - 2am and Sunday, Noon - 2am.
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Glover Park Study Area Map
Saturday, May 21, 2011
Studies and Research
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Broward County Animal Care offers many programs and services to help support and care for our four-legged County residents.
At our two Adoption Centers we offer the opportunity for potential adopters to select and adopt a pet from our many wonderful dogs and cats that need a new home. Shelter staff also provides lost and found services to those that have been separated from their pet.
Within the community, Broward County Animal Care offers rabies vaccinations. We also offer programs that promote responsible pet ownership such as our low-cost spay/neuter SPOT Program. In addition, our team of Animal Care Specialists help to ensure the safety and care of pets through the enforcement of County and State ordinances and regulatory laws.


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When: Friday, February 22, 2013 4:00 PM - 7:00 PM
Where: Stamp Student Union : Adele's Restaurant
Event Type(s): Recreation
Want to celebrate your birthday at GradPub? Email email@example.com with your name, your UID number, copy of a document with your birthdate and the number of people in your party. We will provide the cake, a table reservation and some freebies. We will pick one party at random from all submissions. The eligible range of birthdates is from 02/15 to 03/01. Hurry up and submit your request!
Website: http://gsg.umd.edu/grad-pub
For more information, contact:
Luigi Jhon Alvarado
Graduate Student Government
+1 301 405 2661


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Late June. Greentop, Mo. 100 degrees outside.
100 degrees inside, too, because the Greentop United Methodist Church — where bluegrass bigwig Rhonda Vincent and her band were recording Vincent's first gospel album — has no air conditioning.
"There are some fans, but we couldn't run the fans because it would ruin the recording," says Vincent, who plays the Ryman Auditorium on Thursday. "We opened the windows once, but then a motorcycle drove by, and someone was mowing their lawn, so we had to close it. Our only focus was on getting these songs down and getting this on tape and on camera. It was survival."
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Type of Food: American
Meals Served: Breakfast, Lunch, Dinner
Dress: Casual
Alcohol Served: No
Take-out: Yes
Reservations: Unavailable
Coupons & Specials
Cafe on Main
Welcome to Café on Main, a family-style restaurant serving quality home cooking at an affordable price. Located in downtown Hamlet, NC on Main Street, Café on Main offers daily lunch and dinner specials, salads, burgers, wings, sandwiches, a variety of desserts and a kid's menu.
Our friendly and professional staff is ready to serve you at our restaurant, but if you prefer to order ahead for pick-up, just browse our website and call us at (910)582-8834 to place your order.
Thank you visiting our website and we'll look forward to serving you.
— Amy Guinn


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Terms & Conditions.
Some product exclusions may apply. See product page details for more information. Clearance items are final sale. Price matching does not apply to this or any promotion. Offer is valid until September 13 at 11:59 PM PST. May not be combined with any other offer/discount (unless specified), including invitation credits, promotional gift cards and/or special discount links. Discount applied upon checkout. Log in to your account to see your savings.
Like hot chocolate without marshmallows, your winter look lacks an essential element without a warm scarf wrapped around your neck or shoulders. Made in Nepal from the finest cashmere and silk, this Twisted Tassel Stole by KPA Cashmere tops off your best après-ski ensemble. Or just your regular trying-to-stay-warm-at-the-office getup.
Two tone stole with twisted tassel accents. Stole is reversible.
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Andrew Cashner
National League Mid-Season Team MVPs
Sometimes a team's best players don't make the All-Star team. Here are the National League's mid-season team MVPs.
Andrew Cashner Gets Opening Day Nod For Padres
Andrew Cashner went from the Padres' bullpen to staff ace last season. Can he continue that growth?
Cubs' Anthony Rizzo Could Become Face Of Franchise
Down the line, Anthony Rizzo has the potential to be one of the best offensive players in the league.


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Championship Manager is a great game, I'm into my 8th season with Southampton (don't ask me why).
Javier Saviola is a fantastic player. Any hits on great young players to groom for my squad McBain?
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text: The Knot Genie™ and Teeny Genie™ Detangling Brushes were created for every parent that's endured the foot stomping and screaming matches that come with brushing their child's hair. With the Knot Genie, even the curliest, most knotted up hair practically slips through the unique bristle configuration – gently and painlessly. Try the Knot Genie on your kids (or on yourself) – you'll be amazed by the ease of brushing, as well as how it virtually stops breakage and split ends.


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Interpretive Handbook
83343 :
ThinPrep Diagnostic with Human Papillomavirus (HPV) Reflex
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Squamous cell carcinoma of the cervix is believed to develop in progressive stages from normal through precancerous (dysplastic) stages, to carcinoma in situ, and eventually invasive carcinoma. This sequence is felt to develop over a matter of years in most patients.
Follow-up of the cervical Pap abnormality atypical squamous cells of undetermined significance (ASCUS) is costly and frustrating to patients and clinicians because a large percentage of these patients have normal colposcopic and biopsy findings. Yet, a significant percentage (10%-15%) will have an underlying high-grade squamous intraepithelial lesion (HSIL).
The majority (>99%) of cervical epithelial neoplasms are the result of human papillomavirus (HPV) infection. High-risk HPV (HR-HPV) types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) can result in both low-grade squamous intraepithelial lesions and HSIL, as well as invasive carcinomas. Patients with HSIL have a greater risk for progression to carcinoma.
In the setting of an abnormal Pap result, the presence of HR-HPV types in cervical specimens identifies a subgroup of patients with a greater likelihood of having a HSIL.
If the patient has been previously diagnosed with an abnormal Pap result or is at high risk, considering ordering this test, which is diagnostic, rather than the screen (83342 / ThinPrep Screen with Human Papillomavirus [HPV] Reflex).
Persistent infection with HPV is the principal cause of cervical cancer and its precursor cervical intraepithelial neoplasia (CIN).(1-3) The presence of HPV has been implicated in >99% of cervical cancers worldwide. HPV is a small, nonenveloped, double-stranded DNA virus, with a genome of approximately 8,000 nucleotides. There are more than 118 different types of HPV and approximately 40 different HPVs that can infect the human anogenital mucosa. However, data suggest that 14 of these types (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) are considered high-risk for the development of cervical cancer and its precursor lesions. Furthermore, HPV types 16 and 18 have been regarded as the genotypes most closely associated with progression to cervical cancer. HPV-16 is the most carcinogenic, and is associated with approximately 60% of all cervical cancers, while HPV-18 accounts for approximately 10% to 15% of cervical cancers.(4-6)
Although persistent infection with HR-HPV is necessary for the development of cervical cancer and its precursor lesions, only a very small percentage of infections progress to these disease states. Sexually transmitted infection with HPV is extremely common, with estimates of up to 75% of all women being exposed to HPV at some point. However, almost all infected women will mount an effective immune response and clear the infection within 2 years without any long-term health consequences. An infection with any HPV type can produce CIN although this also usually resolves once the HPV infection has been cleared.
In developed countries with cervical cancer screening programs, the Pap smear has been used since the mid-1950s as the primary tool to detect early precursors to cervical cancer. Although it has decreased the death rates due to cervical cancer dramatically in those countries, the Pap smear and subsequent liquid-based cytology methods require subjective interpretation by highly trained cytopathologists and misinterpretation can occur. Cytological abnormalities are primarily due to infection with HPV; however, various inflammatory conditions or sampling variations can result in false-positive cytology results. Triage of an abnormal cytology result may involve repeat testing, colposcopy and biopsy. A histologically confirmed high-grade lesion must be surgically removed or ablated in order to prevent the development of invasive cervical cancer.
Nucleic acid (DNA) testing by PCR has become a standard, noninvasive method for determining the presence of a cervical HPV infection. Proper implementation of nucleic acid testing for HPV may 1) increase the sensitivity of cervical cancer screening programs by detecting high-risk lesions earlier in women 30 years and older with normal cytology and 2) reduce the need for unnecessary colposcopy and treatment in patients 21 and older with cytology results showing atypical squamous cells of undetermined significance (ASC-US).
Recently, data suggest that individual genotyping for HPV types 16 and 18 can assist in determining appropriate follow-up testing and triaging women at risk for progression to cervical cancer. Studies have shown that the absolute risk of CIN-2 or worse in HPV-16 or HPV-18 positive women is 11.4% (95% confidence interval [CI] 8.4%-14.8%) compared with 6.1% (95% CI, 4.9%-7.2%) of women positive for other HR-HPV genotypes and 0.8% (95% CI, 0.3%-1.5%) in HR-HPV negative women.(7) Based in part on these data, the American Society for Colposcopy and Cervical Pathology (ASCCP) now recommends that HPV 16/18 genotyping be performed on women who are positive for HR-HPV but negative by routine cytology. Women who are found to be positive for HPV-16 or HPV-18 may be referred to colposcopy, while women who are negative for genotypes 16 and 18 may have repeat cytology and HR-HPV testing in 12 months.(4)
Useful For Suggests clinical disorders or settings where the test may be helpful
Management and triage of patient's, age 21 or greater, with abnormal Pap results
Human papillomavirus (HPV) testing detection of high-risk genotypes associated with the development of cervical cancer
Results can be used as an aid in triaging women with abnormal Pap smear results
Individual genotyping of HPV-16 or HPV-18, if present
Results of HPV-16 and HPV-18 genotyping can be used as an aid in triaging women with positive high risk HPV (HR-HPV) but negative Pap smear results.
Interpretation Provides information to assist in interpretation of the test results
Standard reporting, as defined by the Bethesda System (TBS) is utilized.
Human papillomavirus (HPV):
A positive result indicates the presence of HPV DNA due to 1 or more of the following genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68.
A negative result indicates the absence of HPV DNA of the targeted genotypes.
For patients with atypical squamous cells of undetermined significance (ASC-US) Pap smear result and who are positive for high-risk HPV (HR-HPV), consider referral for colposcopy, if clinically indicated.
For women aged 30 years and older with a negative Pap smear result but who are positive for HPV-16 or HPV-18, consider referral for colposcopy, if clinically indicated.
For women aged 30 years and older with a negative Pap smear, positive HR-HPV test result, but who are negative for HPV-16 and HPV-18, consider repeat testing by both cytology and a HR-HPV test in 12 months.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
The Pap test is a screening test for cervical cancer with inherent false-negative results. A negative human papillomavirus (HPV) test or Pap smear result does not preclude the presence of carcinoma or intraepithelial lesion. The false-negative rates of the Pap test range from 15% to 30%.
The Cobas HPV test detects DNA of the high-risk types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68. This test does not detect DNA of HPV low-risk types (eg, 6, 11, 42, 43, 44) since these are not associated with cervical cancer and its precursor lesions.
The Cobas HPV test is not recommended for evaluation of suspected sexual abuse.
Prevalence of HPV infection in a population may affect performance. Positive predictive values decrease when testing populations with low prevalence or individuals with no risk of infection.
Infection with HPV is not an indicator of cytologic high-grade intraepithelial lesion (HSIL) or underlying high-grade cervical intraepithelial neoplasia (CIN), nor does it imply that CIN2-3 or cancer will develop. Most women infected with 1 or more high-risk HPV (HR-HPV) types do not develop CIN2-3 or cancer.
A negative HR-HPV result does not exclude the possibility of future cytologic HSIL or underlying CIN2-3 or cancer.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
ThinPrep Pap Test:
Satisfactory for evaluation. Negative for intraepithelial lesion or malignancy.
Note: Abnormal results will be reviewed by a pathologist at an additional charge.
HPV Test:
Negative for HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Solomon D, Schiffman M, Tarone R: Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst 2001;93:293-299
2. Soloman D, Davey D, Kurman R, et al: The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA 2002;287:2114-2119
3. Wright TC, Cox JT, Massad LS, et al: 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities. JAMA 2002;287:2120-21294.
4. Saslow D, Solomon D, Lawson HW, et al: American Cancer Society, American Society for Colposclpy and Cervical Pathology, and American Society for Clinical Pathology Screening Guidelines for the Prevention and Early Detection of Cervical Cancer. J Low Genit Tract Dis 2012;16(3):175-204
5. Walboomers JM, Jacobs MV, Manos MM, et al: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-19
6. de Sanjose S, Quint WG, Alemany L, et al: Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol 2010;11:1048-1056
8. Wright TC Jr, Stoler MH, Sharma A, et al: Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV positive, cytology-negative results. Am J Clin Pathol 2011 Oct;136(4):578-586
8. Massad LS, Einstein MH, Huh WK, et al: 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis 2013 April;17(5 Suppl 1):S1-S27
9. Sherman ME, Lorincz A, Scott DR, et al: Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis. J Nat Cancer Inst 2003 January;95(1):46-52


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Benefits Of Pure Raspberry Ketone
Fresh raspberry ketone is not just some other bottle on the shelves in the stores. It is a miracle molecule which has been proven to work on several health conditions. Many people have tried it and they have come out with a conclusion that this is a natural supplement with awesome benefits to the health. Ketone can and has many times been used as a flavour to several foods for example ice cream. The beautiful aroma that comes from raspberries comes from the ketones. Therefore pure raspberry ketone has a huge benefit to the human body and we take a look at a few of those.
The biggest benefit that comes with pure raspberry ketone is aiding weight loss. Ketone extracted from raspberry gives the body the ability to produce a certain kind of protein that is used by the body as a breakable compound. Raspberry ketone, also boosts the level of metabolism in the body, thus making it breakdown food and use it to the maximum. When the body is not able to burn all the food you take, then you will definitely end up gaining weight. Taking just a portion of this dietary supplement will give your metabolism the boost it needs to get lean in record time.
Raspberry ketone diet also helps in speeding up the breakdown of fat in the body. All the food we eat almost always has an element of fats or the body makes the same from the sugar and/ or the starch. Once that happens, the fat is thus sent by the liver to the blood stream and carried to the other parts of the body for storage. What raspberry ketone extract does is that, it moves all the fat stored in the body back to the liver to be broken down and gotten rid of. When this happens, the ketone does speed up the break-down of such and at the end of the day leads to weight loss.
Raspberry ketone is known to reduce fatty tissues in the liver. The most dangerous situation is to have fat accumulated around the liver because it will fail. When you take ketone extracts, the fat around the liver will be broken down by the ketone acting as a catalyst to the same. This process will rid the body not just from the fat, but also from conditions like high blood pressure and diabetes which are caused by such. Heart conditions will be gotten rid of as well and all known lifestyle diseases that are known to be caused by accumulated cholesterol in the body.
When all has been said and done, you may be wondering what are the side effects of raspberry ketone? So far, no known side effects have been recorded, even by people who have taken this product for years. Again, no-body has so far come out to study the side effects of this product. Therefore as far as we know for now, raspberry ketone is natural and completely safe for human consumption.
Pure garcinia cambogia extract has generated a lot of buzz, due to its' effect on weight loss. Derived from garcinia cambogia fruits, this plant also goes by the name of gambooge or brindle berry. It is comprised of the compound HCA (hydroxycitric acid).
HCA has been widely researched and clinically proven to facilitate weight reduction. The compound allows the body to process surplus fat, via numerous processes. These include lowering hunger cravings, preventing the production of fat, and elevating mood. Here are some of the ways that pure garcinia cambogia helps with weight loss:
Improved Mental Well Being
HCA facilitates good mental health in two ways. Firstly, it helps to stimulate serotonin production. This mood elevating neurotransmitter reduces anxiety, depression and other mental health disorders. This works wonders for comfort food dieters, who turn to food whenever they feel down. Once their emotional well being improves, these dieters are less inclined to pig out on junk food.
Another way that HCA enhances mental health is by reducing the quantity of cortisol in the body. This notorious "stress hormone" can accumulate over time and result in a range of damaging side effects, such as weight gain. Increased cortisol levels lead to the accumulation of visceral fat deposits, in the abdominal region.
Also, surplus amounts of cortisol hinder the relationship between blood glucose and insulin. This reduces energy levels and causes the brain to transmit hunger signals to increase energy. By lowering the concentration of cortisol, you will have fewer food cravings and start to slim down.
Fat Blocking
HCA can block fat by obstructing an important enzyme that the body requires to produce fat from carbs: Citrate lyase. Normally, sugars or carbs which are not instantly used or stored in another form are turned into fat. Once HCA obstructs citrate lyase, fat production ceases and triglycerides and LDL (bad cholesterol) production reduces.
Suppressing Appetite
Although HCA reduces hunger cravings by lowering levels of cortisol, it can suppress appetite thanks to higher glycogen levels. Higher levels of glycogen trigger liver receptors, sending signals to your brain that you have had enough to eat. This reduces the quantity of calories required to feel full, resulting in healthy weight reduction.
When used for twelve weeks or less, pure garcinia cambogia is safe for most dieters. Safety over the long term is unclear and one should research Cambogia extract pros and cons. The compound can cause headaches, nausea and digestive tract problems. Little evidence exists about the effects of the compound during breast feeding and pregnancy. Therefore, expectant mothers should avoid consuming it.
Lastly, to be effective, garcinia cambogia miracle for weight loss has to be taken in the right way. It ought to be consumed thirty to sixty minutes prior to meals, with a drink of water and on an empty stomach. This allow HCA to be properly absorbed prior to eating, which ensures optimum fat loss benefits. Taking a Garcinia HCA supplement will not help you to lose those excess pounds on its' own. However, combined with regular exercise and a sensible diet, the evidence appears encouraging.
Cholesterol is a huge influence on how our body runs, and the levels of our cholesterol must be kept healthy if we wish to live a longer, happier life. According to Dr. Oz on his smash television show, African mango weight loss supplements are the way to go if you want to keep your metabolism at a quick pace. This will help you lose those few pounds that you have been dreading, so your waistline can shrink to the size that you desire. This supplement has been talked about worldwide, not only because of how it really works, but because of how natural it is.
The supplements that are made from African mango extracts, or Irvingia Gabonensis, are officially the new breakthrough for weight loss for women that are over 40-years-old. The supplements help to trap the fat in your body, so it can later be eliminated. The African mango extract is packed with vitamin B, which is used to increase the rate of the body's metabolism to burn calories quicker. People who are approaching middle age have concerns by the barrel, but most of those concerns surround triglycerides and cholesterol. Clinical studies have indicated that the people who are taking these supplements twice a day, are losing up to 10 pounds by about 30 days after the first one. These supplements contain 150 milligrams of pure African mango extract.
These subjects that participated in the study did not make any adjustments to their exercise routines or their diets, which is clinical evidence that proves folks over 40-years-old will benefit greatly to the African mango supplements for weight loss. When it comes to cholesterol in the mix, this supplement is also very beneficial when it comes to reducing the bad cholesterol, and will also help to clean up the blood stream. So overall, anyone who is remotely health conscious will benefit from these supplements, because of the multitude of benefits that they bring to the table.
This is especially true for someone who has cholesterol problems, since the supplements will help to reduce the levels of LDL cholesterol that is taking control of your body. With the supplements, the HDL cholesterol levels in your body will be increased. Having high cholesterol levels will ruin your cardiovascular system, and will also put you at the top of the list for having a stroke or a heart attack. However, with these supplements, you will be able to lower these levels and improve your overall health safely, and effectively.
Another clinical study had subjects take the supplements, but were also put on a diet with reduced calories. These subjects lost four times the amount of weight that was initially expected, and also proved the point that the African mango extract supplements really do work. These supplements do not have a stimulating effect, reduces your appetite and activates the body's natural ability to burn fat using Leptin, a hormone. The supplements slow this hormone, which allows C-reactive to be absorbed actively into the body and Leptin to flow more freely into the body's blood stream.
Agave Syrup
Many agave syrup consumers enjoy using the syrup, comfortable with the knowledge that it has a significantly lower glycemic index than table sugar. Because these consumers are so focused on the fact that it is an improvement over sugar they often overlook the fact that is extremely high in fructose.
By weight, the fructose content of agave syrup measures somewhere between 59 and 90 percent. High fructose corn syrup, which is more commonly known to be a concern for its high content, has an average of 55 percent. Consumers need to be aware of these numbers and watch how much agave syrup they use.
The high fructose levels in agave syrup can lead to the body becoming resistant to insulin. Insulin resistance is when cells fail to respond the way they should to the normal actions of insulin. The body continues to produces insulin, but because the body's cells are resistant to insulin they are not able to use it effectively. This causes the pancreatic cells to increase insulin production. If this goes on undetected it could lead to Type 2 Diabetes.
High fructose levels have the potential to drive up uric acid levels. There is a strong known connection between fructose and uric acid. The connection is so clear, that uric acid levels can be used as a test to indicate whether the body is suffering toxicity from fructose.
Yacon Syrup
Used as sweetener, yacon syrup is extracted from the roots of the yacon plant. An evaporator, similar to the ones used to make maple syrup is used to make yacon syrup. This syrup is made up of fifty percent fructooligosaccharides.
Fructooligosaccharides are oligosaccharides, or carbohydrates with a low number of simple sugars, that occur naturally in many plants. When Yacon syrup extract, which contains oligosaccharides is consumed, the part that goes undigested serves as food for microflora found in the intestines. The syrup benefits us by acting as a prebiotic.
Microbiotas, or "friendly", bacteria produce essential nutrients such as short-chain fatty acids. When this dietary fiber ferments in the colon it maintains the proper growth of the cells that line the intestines and prevents the growth of infectious organisms. It increases immunity, reduces inflammation, and helps to prevent diarrhea.
Another health benefit that the Fructooligosaccharides in yacon syrup offers, is that it does not increase blood glucose, which means less glucose is able to reach fat cells to be stored there. Because the body then begins to use the stored fat as fuel, the result is a healthy, steady loss of weight..
Since the fructooligosaccharides in the syrup is nearly fifty percent as sweet as processed white sugar, it can be used to add flavor and replace part of the sugar added to food products.
Those who have tired yacon syrup enjoy its sweet flavor and find it tastes much like raisins, prunes, or molasses. It can be used in coffee and tea, added to hot cereal, or poured over pancakes.
Green coffee extract are beans that are not roasted. Roasting coffee beans changes their color and removes a compound known as chlorogenic acid. Chlorogenic acid is compound found in green coffee beans that is responsible for triggering weight loss. The acid disrupts an enzyme known as glucose-6-phosphatase that controls the usage of glucose in the body. This acid has health benefits such as weight loss, containing heart diseases and diabetes among others. It also has some effect on blood vessels that helps in reducing blood pressure.
How they work
Green coffee beans contain some extracts that assist in shedding off excess weight. The extracts work through;
Blocking fat: the extracts work to block fats that cannot be used as energy in the body from being stored. Thus, reduces fat accumulation in the body.
Absorbs carbohydrates: it assists in absorbing carbohydrates that are later used to assist the body in using up the excess fat more efficiently.
Regulates blood sugar after meals: regulation of blood sugar is a factor that is helpful to people who suffer from diabetes. It regulates blood sugar to assist people avoid the different extremes that they experience after having meals. They include an urge to consume more sugar to ensure that their perceived energy levels remain the same.
The main idea is to consume pure green coffee bean extract before meals to assist in the regulation and control of body functions and continue with a diet that you are more comfortable with. It is especially helpful to people who prefer to lose weight without increasing their activity levels or those who cannot exercise due to health issues.
Factors to consider when buying green coffee beans supplements
Green coffee beans supplements are safe for consumption by most people. However, there are some factors that should be considered when purchasing them to ensure that you are purchasing the right thing.
Sugar levels: people who suffer from diabetes should consult their doctors before consuming these supplements because they can affect their medication significantly. It can affect how the body processes sugars.
Blood pressure: green coffee supplements can boost blood pressure levels to risky levels. Therefore, everyone who suffers from blood pressure or any heart disease should consult with their doctor before using the supplements.
Anxiety problems: they are believed to aggravate symptoms associated with anxiety problems. Therefore, people who suffer anxiety problems should seek medical advice before using the supplements.
Most people who use green coffee beans recommend it because it is easy to use and maintain regimen. You are only required to take the supplements three times a day before taking your meals. This means that you do not have to follow a complicated schedule. It triggers weight loss and you are capable of losing at least 2 pounds each weeks meaning that you can lose 24 pounds in 12 weeks without straining. However, some people have reported experiencing some jitteriness during their first few days but they stabilize after a while. At the end, people report having more energy, feeling better and more confident with their bodies.
The acai berry diet plan is mainly known to many as a natural detoxification and weight loss element. Though there are different acai berry benefits, most diets use dietary supplements that contain acai among other herbs, natural substances, vitamins and herbs. Acai berry plan is believed to reduce appetite, boost metabolism and clean the body system.
What it contains
This diet plan advocates for the use of acai among other natural components that assist in weight loss. It contains, chromium, yerba mate and hoodia that boost weight loss. Other components are; cocoa, B vitamins, magnesium, green tea, dandelion, omega 3 fatty acids, cascara sacrada, bladder-wrack and spirulina. The beery fruits itself contains; minerals, phytonutrients, Vitamins, E, D, C, A, B1, B2, B3, omega 3, 6 and 9, amino acids, complex carbohydrates, phosphorous, potassium, calcium, fatty acids, fiber, iron and asai. Acai contains the highest number of nutrient values in the world. It contains protein that is equivalent to a cow's milk and plant sterols that lower blood cholesterol.
Health benefits
Anti-aging effect: contains antioxidants that are known for neutralizing free radicals and preventing early aging.
Strengthening the immune system and detox cleansing: acai berry plan reduces the levels of cholesterol in the body, strengthens the immune system, removes toxins from the body and prevents infectious diseases from attacking.
Normalizing essential processes: the berries contain high amounts of enzymes, fiber, antioxidants and essential fatty acids. These components regulate the blood pressure, offer an effective digestive system, normalizing blood vessels and the heart as well.
Boosting metabolism: the acai berries have low glycemic levels that affect metabolism, supplement daily diets and regulates body metabolism.
Body fitness: it regenerates the muscles after workouts. However, if it is used before any exercises, it boosts stamina among other positive tonic effects.
Healthy skin: plant pigments also known as anthocyanins reduce the destruction process that affects skin cells to counteract aging. After which fatty acids revitalize and nourish the skin.
Vision effects: Anthocyanin strengthens vision and reduces struggling with eye diseases like macular degeneration and glaucoma. In some countries like Japan Anthocyanin is a mandatory diet to everyone using computer for a long period.
Sexual health: acai berries are characterized by a rich and balanced composition of nutrients that boost the stamina and energy as well a boost sexual functioning.
Healthy relaxation and sleep: consuming acai before retiring to bed offers a peaceful, healthy and deep sleep due to its dopamine and serotonin high contents.
It has a positive effect on stamina and muscle regeneration that build the muscle mass, restore and strengthen the bodies immune system.
– This berry diet plan assists in weight loss, blood circulation, body cleansing and digestion.
– Its free radicals assortment prevents the occurrence of wrinkles early.
– They have no proven side effects.
– The plan can be quite expensive but they are worth the price since you can enjoy their benefits.
– There are many possible fakes that contain small amounts of berries.
This plan, is nutritious and healthy plan that is designed to assist everyone in one way or the other.


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Damien Dempsey (born 1975) is an Irish singer and songwriter who mixes traditional Irish folk with contemporary lyrics to deliver social comment on the positive and negative aspects arising from Ireland''s Celtic Tiger society.
This area is intended for discussion only. If you have a question about your order, or require customer service you can get in touch via our Customer Service Area. Comments enquiring about existing orders, including personal details, or with questions will be deleted.


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National Politics Watch
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The ten best and ten worst political campaigns of 2012
From Texan Ted Cruz to Hawaii's Mazie Hirono, there have been some outstanding political campaigns run in 2012. And yet there were more than a few "oops" moments and downright bad campaigns. Here are ten of the best and ten of the worst campaigns of 2012. [Read More]


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Published exclusively for SportsPosterWarehouse.com, this brilliant poster features a classic, archival image of Maravich during his dominating early years, circa 1971 with the team that brought him to the NBA, Atlanta Hawks. Displaying the unique green-and-blue uniform of the day, and his signature floppy socks, this is a perfect example of The Pistol's raw athleticism and creativity as he drives past Lakers Pat Riley and Keith Erickson in a 1971 game at the Forum in Los Angeles. Despite never winning a championship and dying young, Pistol's legacy will live on forever. With this print, you can help hold that legacy high with classic, nostalgic old-school style. The perfect addition to your sports wall-of-fame, and an absolute must for the wall of any Maravich fan!
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- Independent
- The Enterprise
- The Recorder
A serious car crash blocked entry to Cobb Island on Thursday.
Students from La Plata High School and Piccowaxen Middle School who live on the island are being held at Piccowaxen.
The Maryland State Police confirmed that a serious accident occurred on Route 257 and Cobb Island Road about 12:45 p.m. Police didn't release any further details by 3 p.m.
Katie O'Malley-Simpson, spokeswoman for Charles County Public Schools, said the school system was notified that the road to Cobb Island was blocked due to the accident. O'Malley-Simpson said students who live on the island and attend La Plata and Piccowaxen will be held at the middle school until a parent can pick them up.
School staff is notifying the parents of those being held at the school.
O'Malley-Simpson said Dr. Thomas L. Higdon Elementary School had not yet dismissed, and the school system would determine how to handle students from Higdon who live on the island if the road were still closed at the time of its 3:40 p.m. dismissal.


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The smaller case of the SOLO-37 still adheres to Bremont's key principles, yet will appeal to those who desire something slightly lighter on the wrist. Housed in a 37mm Trip-Tick® three-piece case and powered by the modified BE-36AE movement, it is available with a stainless steel or 18-carat rose gold top bezel.
Modified calibre 13 1/4" BE-36AE automatic chronometer, 25 jewels, Glucydur balance, Anachron balance spring, Nivaflex 1 mainspiring, 28,800bph, 38 hour power reserve. Bremont moulded and skeletonised decorated rotor.
Hour/minute/second, date at 3H.
18 carat Rose Gold Bremont Trip-Tick® construction with scratch resistant DLC treated case barrel. Case diameter 37.00mm, lug width 20.00mm.
Stainless steel with integrated flat crystal, 5 stainless steel screws with polished heads.
White metal dial with applied rose gold indexes.
Domed anti-reflective, scratch resistant sapphire crystal.
Water resistant to 10 ATM, 100 metres.
C.O.S.C chronometer tested.
Embossed leather (various colours) with stainless steel pin buckle or stainless steel bracelet with engraved security clasp.
Every watch case and movement is engraved with its Bremont serial number and is accompanied with its C.O.S.C certification.


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Test ID: ABSCM
Antibody Screen, Erythrocytes
Useful For Suggests clinical disorders or settings where the test may be helpful
Detection of allo- or autoantibodies directed against red blood cell antigens in the settings of pretransfusion testing
Evaluation of transfusion reactions
Evaluation of hemolytic anemia
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Transfusion and pregnancy are the primary means of sensitization to red cell antigens.
In a given population, 2% to 4% of the general population possess irregular red cell alloantibodies. Such antibodies may cause hemolytic disease of the newborn or hemolysis of transfused donor red blood cells.
Autoantibodies react against the patient's own red cells as well as the majority of cells tested. Autoantibodies can be clinically benign or can hemolyze the patient's own red blood cells, such as in cold agglutinin disease or autoimmune hemoyltic anemia.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
If positive, antibody identification will be performed.
Interpretation Provides information to assist in interpretation of the test results
A positive result (antibody detected) necessitates antibody identification to establish the specificity and clinical significance of the antibody detected.
Negative–no antibody detected.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Clinical evaluation of antibodies identified is necessary to determine their potential for harm to the patient at this time and to assess appropriate action to be taken in the future.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Technical Manual. 14th edition. Edited by RH Walker. Bethesda, MD, American Association of Blood Banks, 2002, pp 379-418


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The National Medal for Museum and Library Services is the nation's highest honor for libraries and museums that are serving their communities in exceptional ways. Long Island Children's Museum director Suzanne LeBlanc (the a is like "launch") and community members Francisco and Ruth Quijada (sounds like key – ha – da) traveled to Washington from Garden City, NY to receive the national medal and spoke to IMLS about how the museum impacts the community.
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