text:
Apparently adulthood is over.
YA fiction, comic book movies, etc. It all apparently points to a state of perpetual childhood that adults are increasingly living in. Or so some people think.
Thankfully, there has been some extremely thoughtful and sober commentary on this. Among my favorites so far are this Salon piece. I emphatically agree with the economic arguments it makes as well, but it was this part which stood out to me for obvious reasons (bolding is mine):
It's all very well to discuss feminism as a force of cultural liberation expressed by Beyoncé, Lady Gaga and Lena Dunham, but for millions of women in the Western world it has also been an economic imperative, one that set them free from some (but not all) traditional expectations and thrust them into a job marketplace where they are often underpaid relative to their male counterparts. This is too complicated an argument to develop here, but I suspect that the "death of adulthood" is so much more evident among men than women because women are still called upon to perform productive labor – the bearing and nurturing of children – that cannot be or generally is not performed by men.
Elsewhere, another very thoughtful analysis (in Twitter form!) by cultural journalist Jeet Heer, includes truisms like these:
Women have worst of both worlds: must bear the burden of adulthood without enjoying the privileges of patriarchs.
In other words, women, due to endemic sexism and calcified gender norms, have to present as adults, but don't accrue any of adulthood's attendant benefits. In this, as in other things, we don't get much of a choice. Furthermore, Heer points out that laments such as these about the supposedly dismal state of adulthood are themselves a way to prop up the patriarchy (bolding again mine):
Rhetoric of "we are not men our father's were" has been used to shore up male privilege since at least time of Homer.
Fear of the decline of patriarchy is inextricably from patriarchy: it's an essential rhetorical weapon by which authority is shored up.
If that's "adulthood," I say the 1950's and 60's can keep it.
This recent article made the case that no one who likes games should want to be called a "gamer," since the word is associated with all sorts of unpleasantness. To wit:
The term [gaming community] is a miserable legacy of the medium's niche past, where video games were viewed as the sole preserve of white, western indoors-yteenagers. The cliché has proven indelible. 'Gamers' (a term that further segregates 'players', while adding unwelcome ghost notes that call to mind the gambling industry) are routinely represented in media as socially inept boys with poor hygiene and a proclivity for impotent rage, perhaps expressed down a Britney-style head mic while playing online shooters, or typed wrathfully onto an internet forum.
I confess I once mentally defined gamers the very same way. I thought of gamers as people who owned consoles, played first-person shooters (a term I didn't even know prior to this year) and generally spent most or all of their free time gaming.
In my mind, there was a very narrow category of people who could rightly be called "gamers." These people were first and foremost, really good at games. In my mind, they could pick up any game and play it well almost right away. They were really experienced, really knowledgeable and most likely younger and male. Games, I thought, were not for me, a mom of a toddler in her 30's.
Then I got to know Brianna Wu, head of a game development studio that was working on an iOS game. We were both users of App.net for a time and I saw that she was looking for beta testers. She said she specifically wanted casual gamers. In other words, people who didn't have any gaming experience need apply. She mentioned the game had a Choose Your Own Adventure element and that sounded appealing. I used to love those books as a kid. So, I signed up to test what is now the extremely well-received Revolution 60.
I liked the game right away and didn't find it too difficult or stressful to play. It didn't make me feel stupid. It didn't make me feel like this wasn't something for me. It was fun!
Is what games are like now? I started thinking. At that point, I hadn't even played mobile games besides Bejeweled or Gold Miner. We had a Wii and I'd played plenty of Mario Kart and other fun, casual games, but that was about it. I had vague memories of being young and playing Super Mario Bros. and Duck Hunt on a friend's Nintendo down the street, but I don't remember the games grabbing me. I loved Tetris (and actually played it in the USSR in the late 80's on a family friend's computer) but never even owned a GameBoy and certainly not a console. We were immigrants of modest means and something like that would have been a frivolous and unwarranted expense. And besides, I wasn't interested. I had no idea what was out there or why I should care.
After Revolution 60 though, I started asking questions. Were there more games like this I might like? Where are they and what are they called? I started realizing that there were all kinds of games and far from all of them involved shooting people. There was a lot of light, as it turned out, between games like Halo and Call of Duty on one end and Bejeweled on the other. It turned out that even "hardcore" gamers played casual games!
It wasn't long before I got a Steam account. I started trying out all kinds of games there and on Android and iOS and the rest, as they say, is history. I still haven't committed to a console other than the trusty old Wii. But I can see a day in the not too distant future when that may well change.
So I was a gamer now, as far as I saw it. What I learned is that anyone who likes and plays games, any kind of games, can call themselves that. Or at least anyone should be able to. Because alongside learning about games, I started learning something else. I started reading about the rampant sexism that was endemic to the industry. I watched the Anita Sarkeesian videos. I read admissions like this. I watched GTFO. I always innately felt that gaming had a big "NOT WELCOME" sign on it and I started to realize that this was partially because of my gender. I didn't feel like I belonged there. I didn't feel like I would be welcomed.
This, in my opinion, is one of the reasons sexism and other bigotry persists in gaming. People who are perceived to be the "real" gamers are seen by outsiders like me as owning the culture and being in charge of it. People like me feel like we don't have any skin in the game so we can't say anything. That mindset needs to change.
But instead of, as the article at the start of this post suggests, doing away with the word "gamer," I say instead let's ALL call ourselves gamers. Wherever you fall on the spectrum of gaming, start call yourself a gamer and own it. No one has to give you permission to sit at the table. You don't need to own a console. You don't need to have gone to PAX or E3. You don't need to read Kotaku, Giant Bomb, Polygon or any of the other gaming news and reviews sites. You just have to like to play. That's all.
If everyone starts calling themselves a gamer, the stereotypes will die out, the societal stigmas will fade and the dearly needed changes to games themselves and gaming culture will start to happen more rapidly. Let's do this.
Mathew Ingram at GigaOm has recently published a piece entitled Making fun of Silicon Valley is easy, but the next big thing looks like a toy. It bothered me as soon as I read it. Today I saw a few people I generally respect tweeting it and my unease grew. I'll explain.
The point of the piece is, as is the current fashion in online writing, entirely spelled out in the headline. It's fairly innocuous, but the message is clear. If you're making fun of moronic Silicon Valley startups like Yo, or startups in general, you could be stupidly mislabeling the next Twitter or Facebook. Take this line of thought to its logical conclusion and the result is that it would be a mistake to question any new product or service in the tech space. I say no.
The same day that I read Ingram's piece, I read this one on PandoDaily about a startup called Secret. The author of the piece, Sarah Lacy, has numerous concerns about this company and what they have created, concerns that seem eminently valid:
If Secret continues to grow with everyone trying to profit off of its popularity willfully justifying and ignoring the social cost, there will be Secret suicides. As a community, we will regret this. It will make the Craigslist killer and the Airbnb meth head-gate scandals look like nothing.
Lacy is a close watcher of the tech space. She has been writing about technology for 15 years. She has written two well-received books about it. But I guess she didn't get the memo that Valley startups can turn into amazing, wonderful things even if they start out as silly or, in the case of Secret, morally and ethically questionable. She is taking a critical approach and thank goodness, because she explicitly addresses in her piece that others are unwilling or unable to do so.
That being the case, that there is a clear dearth of critical thought about technology, do we really need another exhortation to basically leave Silicon Valley entrepreneurs alone? If even light comedy about a frivolous new app is to be frowned upon, what does that say about the more serious criticism of an Evgeny Morozov or a Sherry Turkle?
The reality is that technology, on its own, is neither a benevolent force, nor an evil one. Your MacBook or your Facebook account don't have feelings and motives. However, the people who built them and programmed them do. To pretend otherwise is utopian foolishness at best. At worst, it is dangerously careless.
First off, I just want to remind everyone that this is not a mommy blog. I repeat, THIS IS NOT A MOMMY BLOG. It never has been and never will be a mommy blog or even a parenting blog which I am told is the newer, more egalitarian term.
That said, I am taking a page from Chris Crocker and asking the Internet to LEAVE PARENTS ALONE!
Here is a blog post that appeared on a website that helps people find caregivers for their children.
My response is in the comments, but in case it is buried under many new ones, I'm reposting it here:
I realize that the goal of a blog like this is to get traffic to the website and controversial topics are more likely to do that. However, since I assume it is your company's mission to help parents, I would think seriously about what you are achieving with posts like these. It might seem like just a good-natured parenting debate, but what I hope you know is that many, many parents are insecure about their parenting and all you are accomplishing here is making those millions of parents question themselves further. In addition, you are putting your readers and commenters in the position of making pronouncements on what the "right" approach is and there IS no one right approach to parenting. This is not the first such post that I've seen, but I've finally gotten fed up enough to comment. The Internet and our media in general are already rife with parenting "advice" and debates that do exactly nothing to help parents unless one considers it helpful to make them doubt themselves further. Please don't add to this sort of noise on Care.com.
Now, I am singling out Care.com here, but as I wrote in my comment, this applies to SO MANY websites, not to mention books, TV shows, etc., etc.
Can we stop the madness, please?
Oh, but parents buy those books, you'll likely tell me. They read those websites! They watch those TV shows! And that's true. It's true, because systematic destruction of your audience's self-esteem is a lucrative industry. Just ask so-called "women's magazines" like Cosmo.
(As an aside, I love how the consumerist justification for all sorts of heinous tripe is that there is a market for it. Heroin has a market too. Does that mean we shouldn't try to stop dealers from selling it?)
So I'm going to say this one more time to Care.com and everyone else who is guilty of this crap. LEAVE PARENTS ALONE!
For a long time, I wanted desperately to work in the media industry. I briefly tasted what success might look like and I wanted more.
To my dismay, I quickly discovered that while everyone loved snarky bloggers (especially people in media), no one was looking to hire one. That sounds amusing now, but it was true as recently as five years ago and personally I think we still have a long way to go in integrating blogging into the mainstream media DNA.
Then, the seemingly impossible happened. I got a job. I was, to put it mildly, THRILLED. Unfortunately things quickly went awry and I was unceremoniously fired approximately 4 1/2 months later. Three days prior to being fired, I had found out I was pregnant for the first time.
I studiously kept looking for any sort of editorial job before I started showing when, I assumed, the jig would be up at interviews. Nothing materialized before my son was born. After, it became impossible even to shower or change into clean clothes for a very, very long time. He's 2 1/2 in three days and I've only marginally improved on that track record.
I did go to work for the Sun-Times Media Group/Pioneer Press when my boy was about a year old. That didn't work out. Four months into a job where my words and my reporting appeared in actual newsprint on a printed page, I felt ambivalent about the work. This was supposed to be my dream come true, but it felt hollow and unsatisfying. I wrote that I still didn't know what I wanted to do with my life. So I started to think bigger. If I couldn't find a media company where I actually wanted to work, maybe I needed to start one of my own.
Something that always irritated me to no end is that good journalism only goes halfway to where it needs to go. It reports on a problem or corruption or a terrible injustice and…. that's it. That's where it ends. The rest of the distance to measurable change is often traversed by activists. Non-profits. Interest groups. PACs. Etc.
As a reader, I have too often experienced the frustration of reading an amazing story and at the end, saying to no one in particular: now what? If I want to do something about this, what exactly should I do? Where should I start? The journalist or her news organization will not help me with this. That would be considered activist journalism and thus very baaaaaad and possibly unethical. Journalists are supposed to be like clouds floating above it all. Seeing all and reporting it, but going no further. On the one hand, I see the value in this approach. On the other, I wholly reject it.
What do we get in the absence of clear-cut ideas and suggestions of where to invest money or time to solve a problem? We get Facebook petitions. Tweets. You-Tube videos you share with your friends. Slacktivism, as its been dubbed. Or we get shrugs and inaction. The problems seem so big and so nebulous that even a motivated reader wouldn't know where to begin.
With Acta Magazine, I want to put a stop to all of that frustration. I want readers and those who want to reach a specific sort of reader to fund important journalism. I want to actually change the world, not just talk about doing it. Most of all, I want to write my own story instead of hoping that one day I can maybe get the sort of ending I want.
Will you join me? I'm doing a live chat soon about Acta, media and anything else people want to ask. Think of it like Reddit's IamAs but for regular people. It will be on Wednesday, April 2 at 3pm CST and will take place here. I hope you'll stop by.
I woke up this morning to news that Ezra Klein is pulling a Nate Silver and likely leaving The Washington Post.
If you want all the details plus smart takes on what this means, I recommend reading Dan Kennedy's piece and also Mathew Ingram's.
For my part, I'm going to tell you a story. Once upon a time, I wrote a blog called The Daily Daley on a now defunct site called The Windy Citizen. It was about Richard M. Daley, the iconic mayor of Chicago, son of the arguably even more iconic Richard J. Daley who was mayor before him.
It was 2008 and this was my first foray into media, a pivotal moment in my life. I had not gone to journalism school. I had not studied it as an undergrad either. I had never written a blog before. I didn't know anything about how online publishing worked. Brad, Windy Citizen's founder, had to walk me through everything. He introduced me to the fundamentals of blogging, gaining an audience, how online traffic worked and so much more. From then on, I learned on my own. I read everything I could about media and journalism and eventually became a small, but vocal voice in the "future of news" crowd, online and off.
As for the Daily Daley, though I worked on it for only slightly more than a year and although it never reached a mass audience, it was read by nearly everyone in the local media. It was snarky and funny and politically informed and I liked to believe that journalists read it because I said the things they couldn't. I remember that years later, I was at an interview for a job at the Chicago Tribune and my interviewer turned out to be a reader of the blog (this happened more than once). I remember him saying he was sad to see it stop. By then, I just shrugged, smiled and didn't say much. There was a time though, when similar interest from a person employed by a major media organization gave me palpitations and delusions of grandeur.
In February of 2009, the Chicago Journalism Town Hall took place. The reason it was convened was this:
Ken Davis, former Chicago Public Radio guy, realized talking to his peers that, as he said, "People are freaked out" by the shift from traditional to online journalism.
Let's put aside for a moment the fact that people were "freaked out" about the shift to online media in 2009. It was a great event and although nothing substantive was accomplished, decided or agreed upon, I believe it was a turning point. It drew attention to the fact that there were definitely two sides in this big sea change that was happening. There were the traditionalists who would cling to the bitter end to the old ways of doing things and there were the futurists who wanted to change everything. Since then, some people have changed sides but the sides remain and they remain obviously not only in Chicago, but all over the country and the world.
But back to my brush with grandeur.
In the ladies' room at the event, I ran into a woman who worked for the local CBS affiliate, let's call her Sue. She too was a fan of the blog. She was enthusiastic and gushed about how she loved my take on politcs. To my delight, she said she had been talking to her boss about putting blogs on their station's website. She said maybe I could blog for them about the impending Rod Blagojevich trial. My eyes must have widened to the size of saucers. An actual media outlet might employ ME? At that point, I hadn't even done the freelancing that would eventually start me down the path to doing actual journalism and getting paid for it.
Sue and I would bump into each other at future events and I would often email her to ask whether I could come in and meet with her boss to talk about the blog. She always said she was working on it. I was naive then and just starting down my path of self-education about how media worked. I actually thought that just because I was good at something, I could get a paid job doing it. Eventually Sue broke the news to me. "He just isn't going for it," she said with genuine regret.
Fast forward back to today and the news about Klein and I find myself crestfallen that things haven't changed significantly. Sure, every old media site has blogs now. They're all on Facebook, Twitter and everywhere else. So much has changed. Except that what is most important has not. What hasn't changed inside the majority of media organizations is the attitude, the culture, or whatever you want to call it. And what else hasn't changed is the rigid hierarchical structure of most news shops. This was the lede of Kennedy's piece for good reason:
What should a 21st-century news organization look like? A single entity, run from the top, with a common set of values? Or a loose network of related projects, sharing a brand and to some extent a mission but operating semi-independently?
Unquestionably it has to be the latter. It must. There is no other way forward, because while it seems right now like the status quo can endure, this won't be the case forever. There are a number of reasons why this is so, but for today I will make the case that someday very soon, news shops that still function like a corporation from the 80's won't be able to attract the best and the brightest. Oh, they might work there for a while, like Silver and Klein and others have done, but they will invariably leave for one simple reason: freedom. The freedom to do what they want. To test new things, to fail and start over, to iterate, to reach new audiences, launch new products and create the future of news. People will say they left for more money. And that might be true to an extent, but it cannot be the full story. It cannot because people like these don't do a job for the money. I know this because I am one of them.
Now, I am hardly a wunderkind on the order of Klein or Silver. I've nowhere near their accomplishments or reach. But I have been fired from one media job and willingly left another, because I cannot work in an environment hostile to innovation. I feel suffocated, frustrated, chained. I am horrified by the inefficiencies and the lack of a will to embrace new things and new ideas, regardless of where they come from.
A company where people do as they are told and don't feel free to suggest changes or, even if they do, know that they have no hope of being heard or implemented,,, this is not a company that can succeed in the 21st century. A company that doesn't embrace their star performers and give them every means to become better is not a company that has a bright future.
I have no doubt that the higher-ups at every major media organization would say, if asked what their mission is, that they want to deliver the news, inform the public, uncover important stories and of course (for many) make a profit while doing so. If that were really true though, there wouldn't be an apparent need to tightly control all aspects of that mission. If you love something, in other words, you have to set it free. I hope it's a lesson old media can learn before they become totally obsolete.
"I've never understood people who watch CNN all day long."
This was said by someone in a discussion I saw happening on App.net recently. Later on, the same person diagnosed the types of people who do this. News junkies, he called them.
I smiled when I saw it. Hello, my name is Anna Tarkov and I am a recovering news junkie. Though I've long shunned TV news as a means of getting my fix (as is fashionable for all news snobs), I abused Twitter and various websites for years. Given my chosen career path, it's hardly surprising.
In the world of journalism and media in general, it is assumed that you are a news junkie. Reporters, broadcasters, web editors, etc work with news all day long so if you weren't a news junkie when you got into the business, you're very likely to become one. Everyone who has worked in the industry knows the feeling. The rush of a fresh, new story is intoxicating. SOMETHING IS HAPPENING, your mind screams and you have to find out all the facts and report them.
Being a passive consumer of news is very similar. A story breaks and suddenly you want to know everything about it and follow all the developments.
For many, news is not a recreational drug. It is highly addictive. And like any addiction, it takes increasingly higher doses to get high. So you start out innocently enough, checking news sites, blogs or Twitter a few times a day or turning on the TV here and there. But pretty soon you're glued to the computer and/or TV screen, terrified of missing something. The symptoms of your addiction are both predictable and strange all at once. For instance, you begin to delight in being the first to know about a story.
"Did you hear about the earthquake in Indonesia?" you ask your coworker. They reply that they haven't and you proceed to smugly give them all the details. In essense, you are reporting the story to them, the same as a journalist would report it to their audience. You are telling them something new, something they don't already know. It's exhilarating, isn't it, being the first to tell someone something? This is precisely what gets many people into the news business. That feeling of telling people what they don't already know is so satisfying that we accept pathetic salaries, crazy work hours and all sorts of indignities in order to keep doing it.
These days of course, you don't have to be employed by a news organization to feel like you have a captive audience who needs and wants to hear from you. If you have a popular blog or Tumblr or lots of followers on Twitter (or all of the above and more), you can be a one-woman newsroom. You know what your audience wants and you enjoy giving it to them. They look to YOU for information, perspective and context. It's a dizzying feeling of power. You have become something greater than a junkie. You are now the dealer.
I still remember the moments when people said they were paying attention to MY Twitter feed for curation on an important story that was then developing. It felt like I was holding the world in the palm of my hand.
Having now gained some distance from those days, I can categorically say my life is better this way. I don't know about every story, I don't know what the latest Twitter war is about, I don't know about the controversy du jour and I don't care.
Like all former addicts, I may always have to watch myself to make sure I don't backslide, but I'm fairly certain I won't. The reason is that I have gained so much by kicking my addiction. I have gained focus for the things that really matter. I now have deep, nuanced conversations about important topics that go beyond the headlines. I have time to work on things I truly care about. More than anything, I have much greater peace of mind. You didn't think it was a coincidence that journalists drink, did you?
So if you're reading this while feverishly scanning Twitter or glazed over from five straight hours of cable news, I have a message for you. There is a life beyond your addiction. Come live it with me.
When I sat down to write this, I thought about doing it all professional-like, pretending it would be something that would appear in Wired or some such. But I decided to opt against that. Why should I pretend that I don't have strong feelings on something? That would be very unlike me. So here goes.
Last night I saw some posts on ADN (that's what users call App.net btw) from someone I have followed on Twitter for years and someone I respect, Patrick LaForge. Editor of News Presentation at the New York Times. Patrick's posts expressed, among other things, a desire for ADN to become distinct from Twitter and Facebook. Reading this, I became compelled to finally write down what I've been wanting to say for a long time.
ADN is not like Twitter. Let me repeat that. ADN is not like Twitter. One more time with feeling. ADN IS NOT LIKE TWITTER.
Allow me to explain the way I know best, by using a metaphor. Think of Twitter as a hammer. It's made of metal, but the metal has been fashioned into a hammer. A hammer is mostly only good for one thing: hammering in nails. I suppose you can misuse it to bash someone's head in, but most people just use it to hammer in nails. So outside of a few edge cases, it has a discrete and finite purpose.
Now think of ADN as metal. It can be shaped into a hammer, but it can also be shaped into anything else metal can be used to make. Currently, ADN looks like a hammer to many people, because that's the most prominent thing that has been made from it. Also, it's recognizable. After seven years of Twitter i.e. the hammer, people see another hammer and say aha! I know exactly what this is. But that doesn't mean it's the only thing ADN is even right now and it certainly doesn't mean it's the only thing it will ever be.
I actually don't understand why the concept is so difficult for people to grasp. All of you reading this probably use Facebook, right? You can use your Facebook account to post updates, photos, share links, etc., but you can also use it to play games and do lots of other things via applications that developers build for Facebook. The same is true of ADN, It's just early still and no one seems to knows about the non-Twitter like applications that have already been built. Many more will surely follow.
Does everyone get it now? I really hope so. If you still don't, why not try it out and see for yourself. You can also sign up for free via the iPhone app or the Android one. And please find me if you have questions.
In my next post, I will talk further about what makes ADN so special and why it is more than worthy of your time and attention. But for now at least, I hope we have the idiotic Twitter comparison resolved.
Until somewhat recently, I've always worn makeup. Like many girls, I started in my teens and never looked back. Why wouldn't I wear makeup? It's what the grown-ups do, right?
As I got older, I learned that less is more, but I continued to put on makeup to go to work, go out (even if just to the grocery store :-)) and practically every other life situation. Very, very faintly, somewhere in the background, I heard men saying that they like when women don't wear makeup. Ha, I thought. That's just because they haven't seen us first thing in the morning. And everybody knows that after a certain age, women don't primp to impress men. They do it to impress other women.
Though never a heavy user, I nonetheless felt naked and unkempt if I left the house without any makeup whatsoever. I felt like everyone was looking at me thinking how ugly I looked (I've thought that plenty even while wearing makeup, but that's a story for another day). I felt self-conscious. I felt judged, mostly by myself as it turns out. Putting on makeup to me meant a woman cared about her appearance and took the time to make it a priority. The alternative was obviously a lazy slob who couldn't take even 5 minutes to powder her shiny nose.
Everything changed after the birth of my son in the Fall of 2011. I suddenly had no time and no perceived need for makeup. With a newborn, especially one like mine, you don't leave the house much.
At first, I thought I'll go back to my old makeup routine eventually. And I still did it occasionally. A wedding. A job interview. The seven months that I went back to full-time work. But then something started to happen.
The more I saw myself without makeup, the more I realized I actually liked how I looked. So I stopped putting on anything to leave the house, not even concealer or powder which is makeup that is somewhat undetectable as such.
It felt kind of exhilarating. Freed from the fear that people were staring at me and thinking I looked terrible, I felt so much more comfortable in my own skin. It radiated to other things too, like body image. No one loves their body after having a baby and I still want to make changes for my health, but I've accepted myself for now and it feels fantastic.
I'm hardly the first to the no makeup party of course. The image atop this post is from a Twitter account promoting natural beauty and the #nomakeup hashtag on Twitter is always fairly active.
So I decided recently to ask women on my new favorite online place, ADN, for pictures of them without any makeup. I was surprised at how many readily shared them and I want to share them here so that we can all see what true, unadulterated beauty looks like. Some of these came from Twitter as well and you'll find a link to the lady's ADN or Twitter profile next to each photo.
Please enjoy and if you're a woman who always, always wears makeup, I'm not judging you. You should do whatever you like to feel beautiful. But maybe you could try this sometime.
Jessica, wife of Jeff
And finally me.
I hope this helps give some of you the courage to try going without makeup. And if you do, I hope you'll find it as liberating as I have.
Russians in a Skokie Panera are discussing Rahm Emanuel in a way that makes me very, very tired. Allow me to explain.
It's an older woman and an older man. The man lives in Florida and is here visiting. The woman fills him in on local current events. Let's call her "Irene" and let's call him "Boris."
Irene: There was a demonstration yesterday about the school closings. You know, on the south side.
Boris: Oh yeah?
Irene: Do you know what one of the placards said? "Jewish Decision." Why did he [Rahm] have to get into this office? Why be in a position of political power at all? As soon as someone gets in, they hate all of us.
To many Jews, this will sound familiar. I have heard this all my life growing up. My father used to say that at the manufacturing plant where he worked, people blamed everything that was wrong with the economy on Alan Greenspan, another Jew in power. And that's just here in the U.S. You can imagine what they said in the Soviet Union.
The thinking then goes that Jews should stay out powerful positions, lest all other Jews suffer for decisions they make that could foment Jew hatred.
When I hear things like this, I think are you freaking kidding me? Who cares if Rahm Emanuel is Jewish?
Then I think Christ (ha!), are there really people who blame Jews in this way?
I guess I live in echelons of society where this is not the norm, but I've always been warned it exists elsewhere. I don't know to what extent it exists. It's almost like a Jewish urban legend, but it strikes into my chest a visceral fear nonetheless. The Jews who lived in Hitler's Germany also thought they were so deeply integrated into society than no one saw them as different, as "other."
But now "Irene" and "Boris" have turned to discussing something else I'm very familiar with; the unfortunate situation of someone's grand-daughter. The poor girl is 25 and unmarried.


text: Watch a video Watch a video review from one of our experts Front Alternate view Product box Photos (3) Video View larger Sennheiser IE 60 Sound-isolating earbud headphones Item #: 143IE60 2 Reviews This item is no longer available. Original Price: $249.99 Shop all Headphones Need help? 1.888.955.6000 Email Chat Ask an expert advisor No pressure, no commission — just lots of good advice from our highly trained staff. Overview Reviews Details Accessories Articles & Videos by Dave Bar Enjoy high-definition sound on the go Designed for critical listeners, the Sennheiser IE 60 in-ear headphones deliver accurate, full-bodied sound while effectively blocking out external noise, so you can enjoy your music at lower and safer volume levels. Their high-performance dynamic drivers serve up plenty of sonic detail. You'll hear clear, highly articulated sound drums with lots of of "snap" and body, guitars and acoustic instruments with natural warmth and openness, plus taut, tuneful bass. Helpful extras add to your comfort Ergonomically designed soft silicon ear tips help create a seal that minimizes ambient sound. Sennheiser includes a variety of different sizes and types to help you get a comfortable, custom fit. Made to worn with the cables looped behind-the-ear, the IE60s also come with detachable ear hooks that flex and bend to hold the headphones gently, yet securely in place even when you're on the go. And the supplied carrying case gives you a safe place to store your headphones when not in use. Product Highlights:sound-isolating earbud designincludes assortment of soft ear tips for a comfortable fitdynamic drivers with neodymium magnetsattenuation of ambient noise: up to 20 dBfrequency response: 10-18,000 Hzimpedance: 16 ohms48" straight cord with stereo mini plugdetachable earhooks with a flexible/bendable designincluded shirt clip and cleaning toolsliding, magazine-style protective carrying casewarranty: 2 yearsOur 60-day money-back guarantee Sennheiser IE 60 Reviews Average Customer Review: 2 reviews Review this product Submit a review and then enter to win a $350 rewards card Filter by rating: 5 Star: (0) 4 Star: (0) 3 Star: (0) 2 Star: (0) 1 Star: (0) Review this product: Thanks for taking the time to share your experiences about this product. Please be sure to focus your comments on the product itself. Read our Review Guidelines for more information. Review title * Email Your email won't be visible. Please use the email address that is associated with your order. Display name (e.g., JohnD) Your review will be signed using the display name and location * Your location (e.g., Charlottesville, VA) * Your rating Click on a star to rate the overall product on a scale of 1-5 Rate the following specific attributes Sound Quality "Coolness Factor" Build Quality Comfort Noise Reduction 1500 characters left * Your review Attach a YouTube Review Crutchfield Video Review Guidelines Only submit videos that you made or are authorized to use. Do not submit videos that contain music, video or visuals that are copyrighted and belong to someone else. Please see our Review Guidelines for more information. Enter the URL of your YouTube™ video review or product demonstration. e.g., "http://www.youtube.com/v/o79TWHh598U" 500 characters left Pros 500 characters left Cons * Agree to Terms By checking this box you agree your review becomes the property of Crutchfield, that you are over 18 years of age, that you own or have owned this product, and that you are located within the United States or its territories. Please see our Review Guidelines for more information. We reserve the right (but are not obligated to) review all submissions and edit or remove any review in any manner which we deem necessary. Your review should be posted within seven days. Expensive, yet not good Written By KarlL, Crestview Hills, KY on Tuesday, August 20, 2013 Crutchfield Customer Review (What's this?) "Coolness Factor" Build Quality Comfort Noise Reduction Sound Quality These are bazaar. I have an older set of Sennheiser buds with the loop that wraps around the back of the neck which have excellent sound, so I was looking forward to a lighter, even better performing earbud set. These were terrible. the design for fitting in the ear is bazaar, and totally ineffective. They fell out of my ears easier than stock ipod buds without the little add-on loops. With the add-on loops the stay loosely in the ear. the sound quality is poor with very little bass unless they are jammed into the ear canal to about the depth of the temporal lobe. However, none of the sizes of bud tips could keep them jammed in that far even if I was willing to accept the lack of comfort. The performance of these in terms of actual sound quality when wearing them during running or walking is not as good as ten-dollar sony buds with the built in earloops (which claim no better than "good" quality). The fit is poor as far comfort and retention. Pros: Able to return them easily through the excellent service at Crutchfield. Makes every other earbud in existence seem good. Cons: Very poor performance. High cost. 1 out of 6 people found this helpful Was this review helpful? Yes No excellent head phones, ok noise isolation Written By joev, Richmond, TX on Monday, May 14, 2012 Crutchfield Customer Review (What's this?) "Coolness Factor" Build Quality Comfort Noise Reduction Sound Quality I have these and the Monster Cable Pro Gold, and these fit soo much better in ear, thus making them a lot more comfortable. Also the cable going over the ear is more comfortable than I thought it would be. The Noise Isolation is fair even after going through all of the included ear bud options. The sound quality is excellent, even in comparison to the MC Golds, but that may be due to the better fit. They work well for airplane travel. Pros: SQ, fit, quality, comfort. Cons: Noise reduction is only fair, but still adequate. 7 out of 7 people found this helpful Was this review helpful? Yes No Hands-on research Features and specs chart | What's in the box? | In-depth notes What's in the box? Download owner's manual IE 60 in-ear headphones (medium silicon earbuds installed) with a connected 4' cable (3.5mm plug) Pair of small silicon earbuds Pair of large silicon earbuds Pair of small Lamella earbuds Pair of medium Lamella earbuds Pair of large Lamella earbuds 2 Ear hooks Cable clip Cleaning tool Hard protective sliding case Safety Guide Quick Guide Features and Specs General Fit Style In-ear/Earbud Earcup Type Closed Noise-canceling No Bluetooth No Frequency Response 10-18k Hz Sensitivity 115 dB Impedance 16 Ohms Weight 0.49 ounces Cord Length 48" Airline Adapter Included No iPod Control No Volume Control No Built-in Microphone No Parts Warranty 2 Years Labor Warranty 2 Years Product Research Features Overview: The Sennheiser IE 60 noise-isolating, ear-canal headphones are designed for on-the-go listening. The in-ear design gives you excellent attenuation of ambient noise (up to 20%) so you can enjoy your music, even in noisy environments. The IE 60s come with two types of ear buds in three sizes each, flexible ear hooks, a cleaning tool, and a sturdy storage case. Drivers: Neodymium magnets provide the power for the dynamic transducer system. These strong, but tiny magnets give you enhanced bass response and greater sound definition. Earbuds: The headphones come with two types of ear buds: silicone and lamella (or staged). There are three sizes (small, medium, large) for each type. The silicone ear buds are found on most in-ear headphones, and are made of soft silicon rubber. The lamella ear buds have two stages to give you a better fit and more noise isolation than the silicone ear buds. Ear Hooks: The headphone cable can be worn straight down from the ears or looping around the ears. If you choose to wear the cable looped around the ear, the flexible ear hooks can be used to conform the loop to the shape of each ear for a more comfortable fit. Cable/Remote: The IE 60 has a 4' symmetrical, straight cable with a 3.5mm miniplug terminal. A sliding cable cinch lets you eliminate the slack in the cable for better comfort. Storage Case: The included storage case has a sliding drawer opening with molded foam rubber for the ear buds and an indentation for winding the cable. Extra ear buds can be stored on posts on the top of the drawer, while the cleaning tool can be stored on the bottom. There is a space for storing a desiccant packet to keep moisture away from your headphones. Specifications: The IE 60 has the following specs: Frequency Response: 10-18kHz Nominal Impedance: 16 Ω SPL (1 kHz/1 Volt): 115 dB THD (1 kHz): < 0.1% Connector: 3.5mm Weight: 0.49 ounces (14 grams) Our Product Research Team At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team. They verify what's in the box, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices. Sorry, the Sennheiser IE 60 is no longer available. Looking for a similar item? Shop all All Headphones Or, you can still... Write a review Purchase accessories for this product Download the product manual Search the website Go

subset: commoncrawl


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|News » Archives
ETSU Downs Terriers in Four Games
Friday, November 01, 2002SPARTANBURG, S.C. -- The Lady Bucs defeated Wofford Friday night in SoCon volleyball action at the Benjamin Johnson Arena.� East Tennessee State dropped the first game, 28-30, before rebounding to win the next three with scores of 30-24, 30-25, and 31-29. With the win, the Lady Bucs improve to 6-18 on the season, including a 4-11 SoCon record.� Wofford falls to 14-14 overall and 5-10 in league play. East Tennessee State's Nicole Ryan (Etiwanda, Calif.) led all players with 22 kills in the contest.� Kate Steidle (Waynesboro, Va.) finished with 19 kills, and Meghan Connolly (Solon, Ohio) picked up the double-double with 10 kills and 13 digs.� Setter Renee Vesey (Paw Paw, Mich.) had 57 assists in the match. Janna Webb led Wofford on the night with a double-double of 21 kills and 14 digs.� Libero Lindsay Lyman led the match defensively with 25 digs.� Setter Molly Bushong notched 57 saves in the match.� Katie Sobczyk tallied 15 kills and 12 digs for the Terriers, while Currie Gossett had 12 kills in the contest. East Tennessee State will continue its road stretch, facing Furman at 1 p.m. Saturday.


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Its interesting if you just pay attention to Martin I find he looks a hell of a lot more comfortable playing left tackle then he does at right tackle, although that could just be because he was more comfortable playing in the NFL period.
watching the highlight jake didn't look bad at all I think he was injured all year he held Demarcus Ware without a pressure and sack just a year ago on thanksgiving. This OL was playing really well in October and I think with more continuity will build off the way they were playing when we were in wild card contention
I just don't understand how some people can't see Tannehill's immense potential when watching his highlights. Dude can fit the ball into some extremely tight spaces, he has mobility to get him out of jams, and can go through long stretches of games without throwing INTs. Seems pretty promising to me, especially when one considers the weapons he had around him.
Loving that this ends wth victory formation.


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Psychology is the behavioral science that seeks to understand people and how they relate to their environment. Such understanding contributes to performance in all types of job settings, from education, to business, to military, and to health professions. The undergraduate major provides a broad coverage of the discipline, as well as research and applied opportunities, to prepare students for graduate education or diverse career paths.
The Department of Psychology has 28 full-time faculty members representing a broad spectrum of areas in psychology. It is located in the Mills Godwin Building, which includes specialized laboratories for teaching and research in the study of such topics as child development, community psychology, cognitive psychology, industrial/organizational, human factors or engineering psychology, teaching and learning, psychological assessment, and social behavior.
The Department of Psychology offers the following degrees: Bachelor of Science (on campus and online), Master of Science in Psychology, Doctor of Philosophy in Applied Experimental Psychology, Human Factors, or Industrial/Organizational Psychology, and Doctor of Philosophy in Clinical Psychology (offered as part of the Virginia Consortium Program in Clinical Psychology). The department also offers an undergraduate minor in psychology. The programs offered at Old Dominion University prepare students for many jobs in the field of psychology. For more information on the degree programs offered in Psychology please visit the "Academics" links in the menu bar to the left.
Thank you for your interest in our programs! You can access a video of our Chief Departmental Advisor discussing the degree here.
James P. Bliss, Ph.D., Chair
Psychology Dept.Mills Godwin Building, Room 250Old Dominion UniversityNorfolk, VA 23529(757) 683-4439


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Hi guys,
I'm fixing to take on a large project, and will probably be needing a lot of advice. I've got a 1977 Chevy 1ton dually that I am building a winch truck out of. I already have a bed off another truck that is 10' long by 8' wide and is already set up for gin poles and has a rolling tailboard. I do not yet have a winch for it though, any advice here would be appreciated. I am also planning on pulling the stock 350 and replacing it with a 12v Cummins diesel, any pointers here are also appreciated. Will be posting pictures as it comes along.
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Thread: Fixing to take on large project
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Fixing to take on large projectMiller Thunderbolt XL AC/DC
1994 Chevrolet C2500 Diesel
1992 Ford Explorer
1990 Ford F150
1980 Ford F150
1977 Chevrolet C30
Large Assortment of Hand and Power Tools


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| Posted: May 26, 2015
The most widely held and understood definition of extreme poverty, established by the World Bank, defines poverty in strictly economic terms — earning less than $1.25 a day.
Worldwide 600 million children live in extreme poverty. Almost half the world — over 3 billion people — live on less than $2.50 a day.
The poor themselves describe poverty in terms of suffering relationships.
A survey conducted in Niger in 2002 by the Office of the Prime Minister asked the poor of that country to describe poverty. Their answers provided the following:
Poverty is a cancerous, thieving parasite plaguing the destitute. But it's not invincible.
Poverty is an overwhelming, frightening and debilitating beast. But it can be defeated. Child sponsorship helps.
Poverty is an opportunity to provide an opportunity. It's an opportunity to kill the worm that eats away at children's hearts, minds and self-esteem.
It's an opportunity to free a child from a life sentenced to dependence, scarcity and marginalization.
Hand a child the key to freedom. Sponsor a child today.
On average, a child in our sponsorship program spends 4,000 hours in safe, nurturing programs, is at least 50 percent more likely to graduate college and is 35 percent more likely to find white-collar employment as an adult.
What does poverty mean to a child orphaned by cancer or abandoned by his father? It means he has to learn how to dream again.
What does poverty mean to the great aunt taking care of her niece's children? It means fear. Fear that someone may take the children away from her.
What does poverty mean to a mother who lost her two-year old child to pneumonia while waiting at the hospital for treatment? It means the Body of Christ is a refuge.
What does poverty mean to a boy who learns about Jesus Christ on a regular basis? It means self-respect and the ability to love.
What does poverty mean to a child without a sponsor? It means a sponsor is needed.
Children in our sponsorship program are at least 30 percent more likely than their unsponsored peers to become leaders in their communities and at least 40 percent more likely to grow into church leaders.
Help one of these children dream. Give them courage to fight their fear. Lay the foundation for self-confidence. Provide some hope to a child who may be in the midst of losing hope.
Sponsor a Child Today!
Dominican Republic
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has been one of my greatest joys." -- Brianne
Your donation to the Where Most Needed fund will help Compassion better serve children in extreme poverty.
"Thanks for fixing my heart!" - Fatao, a Compassion-assisted child from Burkina Faso


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John Legend to Produce Romantic Hollywood Musical Starring Miguel
John Legend is set to try his hand at producing a big Hollywood musical, with Miguel along for the ride.
Hear Miguel Cover Elton John's 'Bennie and the Jets'
Earlier this week saw the release of Fall Out Boy's contribution in the form of a high-energy take on the song "Saturday Night's Alright for Fighting."
MusiCares Tribute To Carole King Spans Generations, Genres
Steven Tyler, P!nk, Lady Gaga, Sara Bareilles, Zac Brown, Miranda Lambert, Miguel and Alicia Keys were among the many artists who paid tribute last night to one of the greatest songwriters of popular music.
Christina Perri to Appear on 'Girls' Vol. 2 Soundtrack
The soundtrack will also include songs from Lily Allen, M Ward, Beck and Christina Perri.
Pink, will.i.am, Sara Bareilles, Miguel & More Added to Carole King MusiCares Tribute
Newly announced performers include: Sara Bareilles, P!nk, will.i.am, Miguel, Alicia Keys, Sugarland's Jennifer Nettles, Train, Martina McBride, Jakob Dylan, Darlene Love, Amy Grant, Gloria Estefan, and many more.
Lorde & More Added to GRAMMY Nominations Concert 2013
Lorde is the latest addition to this weekend's star-studded GRAMMY Nominations Concert Live!! — Countdown to Music's Biggest Night.
Miguel Covers Pink's 'Just Like A Pill'
With just an acoustic guitar, Miguel slowed things down and got to the heart of the track, which was featured on Pink's 2001 album, 'M!Ssundaztood.'
Mariah Carey Lands In Hospital During '#Beautiful' Remix Video Shoot
The singer's spokeswoman, Cindi Berger, confirmed that Mariah was injured while filming the clip for the remix of "#Beautiful" featuring rapper Young Jeezy.
New Mariah Carey Album Coming This July
Mariah Carey surprised fans on Twitter yesterday (June 5) by announcing the release date of her new album. This will be the singer's 13th release.
Miguel's Billboard Awards Jump May Land Him in Legal Trouble
Miguel was (literally) kicking with excitement during his Billboard Music Awards performance, but his miscalculated jump is landing him in hot water.


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Late stage assay provider counterscreen results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): chemiluminescence-based western blot assay for inhibitors of Early Growth Response 1 (EGR1) protein levels in DLD1 cells
Name: Late stage assay provider counterscreen results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): chemiluminescence-based western blot assay for inhibitors of Early Growth Response 1 (EGR1) protein levels in DLD1 cells. ..more
BioActive Compounds: 3
Related Experiments
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC)
Affiliation: The Scripps Research Institute, TSRI
Assay Provider: Vincent Yang, Emory University
Network: Molecular Library Probe Production Centers Network (MLPCN)
Grant Proposal Number: 1-R03-DA026215-01
Grant Proposal PI: Vincent Yang, Emory University
External Assay ID: DLD1-EGR1_INH_WESTERN-BLOT_HRP_%INH MCSRUN
Name: Late stage assay provider counterscreen results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): chemiluminescence-based western blot assay for inhibitors of Early Growth Response 1 (EGR1) protein levels in DLD1 cells.
Transcription factors are essential regulators of transcription that bind DNA to control both the rate and frequency of gene expression (1). Many diseases of cell homeostasis are associated with aberrant transcription factor activity (2). Colon cancer, in particular, is a disease of uncontrolled proliferation of the epithelial cells that line the intestinal crypts. Kruppel-like factor 5 (KLF5) is a zinc finger-containing transcription factor that binds to GC-rich sequences in promoters of numerous genes (3) including cyclin D1 (4), cyclin B1/Cdc2 (4), and integrin-linked kinase (5). KLF5 is highly expressed in rapidly dividing epithelial cells in intestinal crypts (6). This expression pattern of KLF5, along with studies demonstrating that KLF5 mediates the transforming effects of oncogenic H-Ras (7), and that ectopic expression of KLF5 leads to increased cell proliferation and anchorage-independent growth of cultured intestinal epithelial cells (8, 9), suggest that KLF5 may be involved in colon cancer pathogenesis. Therefore, the identification of selective inhibitors of KLF5 may provide useful tools to elucidate the role of KLF5 as a regulator of cellular proliferation and tumor formation in the intestinal epithelium.
1. Ptashne M. Regulation of transcription: from lambda to eukaryotes. Trends Biochem Sci. 2005 Jun;30(6):275-9.
2. Fre S, Vignjevic D, Schoumacher M, Duffy SL, Janssen KP, Robine S, Louvard D. Adv Cancer Res. 2008;100:85-111. Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms.
3. Goldstein BG, Chao HH, Yang Y, Yermolina YA, Tobias JW, Katz JP. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1784-92. Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells.
4. Ghaleb AM, Nandan MO, Chanchevalap S, Dalton WB, Hisamuddin IM, Yang VW. Kruppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 2005 Feb;15(2):92-6.
5. Yang Y, Tetreault MP, Yermolina YA, Goldstein BG, Katz JP. Kruppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem. 2008 Jul 4;283(27):18812-20.
6. McConnell BB, Ghaleb AM, Nandan MO, Yang VW. The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays. 2007 Jun;29(6):549-57. Erratum in: Bioessays. 2007 Sep;29(9):946.
7. Nandan MO, Yoon HS, Zhao W, Ouko LA, Chanchevalap S, Yang VW. Kruppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene. 2004 Apr 22;23(19):3404-13.
8. Chanchevalap S, Nandan MO, Merlin D, Yang VW. FEBS Lett. 2004 Dec 3;578(1-2):99-105. All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5.
9. Sun R, Chen X, Yang VW. J Biol Chem. 2001 Mar 9;276(10):6897-900. Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation.
EGR1, early growth response 1, Late stage, late stage AID, powders, purchased, synthesized, DLD, DLD-1, cells, KLF5, KLF, BTEB2, kruppel-like factor 5, cancer, Western blot, immunoblot, protein, counterscreen, inhibitor, inhibition, assay provider, Scripps, Scripps Florida, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN.
Assay Overview:
The purpose of this assay is to determine whether powder samples of compounds identified as possible KLF5 inhibitor probe candidates change protein levels of the nuclear transcriptional regulator Early Growth Response 1 (EGR1). In this assay, DLD-1 cells are seeded in 12-well plates, treated with test compounds for 24 hours, followed by lysis in Laemmli buffer and determination of protein levels using standard western blotting protocols. Actin is used as an internal control. This assay was run in the assay provider's lab. Compounds were tested in singlicate at a nominal concentration of 10 uM.
Protocol Summary:
The parental DLD-1 cell lines were routinely cultured in T-175 sq cm flasks at 37 C and 95% relative humidity (RH). The growth media consisted of RPMI -1640 (DLD-1) supplemented with 10% v/v certified fetal bovine serum, and 1X antibiotic mix (penicillin, streptomycin, and neomycin).
Prior to the start of the assay 2 x 10e5 cells in a 1 mL volume of growth media were dispensed into each well of 12-well tissue culture-treated plates. The assay was started immediately by dispensing 4 mL of test compound in DMSO (0.4 % final DMSO concentration), DMSO alone to the appropriate wells. Next, the plates were incubated for 24 hours at 37 C (5% CO2, 95% RH. After 24 h of incubation, cells were lysed in 200 uL Laemmli buffer and subjected to electrophoresis in 10% polyacrylamide gel. The proteins were then transferred to a nitrocellulose membrane and developed with appropriate antibodies. The DMSO treated cells were considered as 100% (control). We did not perform any statistical analysis as this experiment was performed once.
PubChem Activity Outcome and Score:
Compounds were considered active if percent inhibition or activation in protein levels value were greater than or equal to 30%. Compounds were considered inactive if percent inhibition or activation in protein levels value were less than 30%.
The reported PubChem Activity Score has been normalized to 100% observed absolute value of the fold change.
The PubChem Activity Score range for active compounds is 100-92. There are no inactive compounds.
List of Reagents:
DLD-1 cell lines (assay provider);
Laemmli buffer (assay provider)
Primary antibody
Rabbit anti-EGR1 (Cell Signaling, Part 4153)
Mouse anti-B-actin (Sigma Aldrich Part A1978)
HRP-conjugated Secondary antibody: goat anti-rabbit and goat anti-mouse (vendor & part information not provided by assay provider)
Chemiluminescent developer (Millipore, part not provided by assay provider)
This assay was run by the assay provider's lab. This assay may have been run as two or more separate campaigns, each campaign testing a unique set of compounds. All test compound concentrations reported above and below are nominal; the specific test concentration(s) for a particular compound may vary based upon the actual sample provided.
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
BAO: assay design: binding reporter: western blot
BAO: assay format: cell-based format
BAO: bioassay specification: assay biosafety level: bsl1
BAO: bioassay specification: assay control: background control: Actin
BAO: bioassay specification: assay measurement throughput quality: single concentration single measurement
BAO: bioassay specification: assay measurement type: endpoint assay
BAO: bioassay specification: assay readout content: assay readout method: regular screening
BAO: bioassay specification: assay readout content: content readout type: single readout
BAO: bioassay specification: assay stage: secondary: mmoa characterization
BAO: bioassay specification: bioassay type: functional: process
BAO: detection technology: luminescence: chemiluminescence
BAO: meta target detail: binding reporter specification: interaction: protein-small molecule
BAO: meta target: biological process target: regulation of molecular function
BAO: meta target: molecular target: protein target: transcription factor
BAO: version: 1.4b1090
From PubChem:
Assay Cell Type: DLD-1
Result Definitions
** Test Concentration.
Additional Information
Grant Number: 1-R03-DA026215-01
Data Table (Concise)


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- 423
- people in the U.S. have this name View Cynthia Hansen on Whitepages
Meaning & Origins
From Greek Kynthia, an epithet applied to the goddess Artemis, who was supposed to have been born on Mount Kynthos on the island of Delos. The mountain name is of pre-Greek origin. Cynthia was later used by the Roman poet Propertius as the name of the woman to whom he addressed his love poetry. The English given name was not used in the Middle Ages, but dates from the classical revival of the 17th and 18th centuries.
|62nd in the U.S.
Danish, Norwegian, Dutch, and North German: patronymic from the personal name Hans.
|185th in the U.S.
Nicknames & variations
Cynth, Cyntia, Cynthea, Cyntha, Cynthi, Cynthya, Cynthie, Cynt, Cynthy, Cynthiaa
Hanson, Hans, Hansel, Hansford, Hanshaw, Hansell, Hanscom, Hansard, Hanselman, Hanssen


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Start the feast on time, every time and cook multiple dishes at different temperatures with two ovens in one. Flaky pies won't have to share the spotlight—or temperature—with the roast beef. Now you'll be able to join the family for dinner with everything done at the same time.
Maytag brand gives you peace of mind with a 10-year limited parts warranty2 that covers the cooktop as well as the elements.
When you buy a Maytag brand appliance, you get the quality and dependability you've come to expect. You also get a product that puts Americans to work in towns all across the U.S. We call it American Pride.
H: [Ljava.lang.String;@68836883"
W: [Ljava.lang.String;@68bb68bb"


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|Description :
|Laser Precision are a division of DFW Movers & Erectors, Inc. serving Austin to provide you with the best possible service including laser & machine alignment, vibration analysis and alignment tool serving throughout Kyle, Fort Worth, Dallas, Garland & San Antonio. We provide fast and accurate machine alignment service to correct alignment errors and increase productivity. Contact us on 817-222-3200 for more information.
|Address :
|3201 N Sylvania Ave Suite 401, Fort Worth, TX, USA, 76111
|Phone :
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|Average Visitor Rating :
4.13 (out of 5)
Number of ratings: 94 Votes


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I wasn't suggesting on doing any modifications to the 325. I was just trying to figure out a way to cool it better, more theory if anything. Engine starts becomming erratic, or surging, I'll just continue on resetting the ECU as that appears to remove the problem.
Results 1 to 10 of 28
Thread: TB325 issue
TB325 issue
05-16-2013, 05:37 PM #2Senior Member
- Join Date
- Feb 2009
- Location
- Lodi, CA
- Posts
- 1,315
cruiser, am I correct in assuming this is essentially a generator/alternator powered inverter, just like the original pipepro was???Obviously, I'm just a hack-artist, you shouldn't be listening to anything I say .....
Nope, same basic tech as a Ranger 305 with the chopper, so more of a hybrid. Same tech in the PP350. The PP304 is a generator powering a converted xmt304.
I'm just concerned with the 325 with its 25 horse EFI kohler making too much heat, and no where really for it to go, let alone cool air getting to it in a hot enviroment. Like I mentioned, in the winter, they didn't give too many problems, but now, and its only May, I get calls every day.
Like every machine, there are quirks
Now Kohler allows you to add a hot air kit, which in my opinion bakes the oil and cam. so adding a cold air kit providing kohler okays it or has one, is zero to do with Miller warranty. If it extends the life of the engine and subsequent components, I can't see Kohler disapproving of it.
If a motor cycle can have a radiator why don't they design a small CI welding machine engine that has one? It's getting to the point el cheapo global competition is going to ruin the world not make it better.
05-16-2013, 07:49 PM #6Member
- Join Date
- Nov 2011
- Location
- Edmonton
- Posts
- 43
Would have been better off keeping it the same size as the 302 and add some cooling system to it, if it would avoid these overheating issues which I'm almost certain had to do with my machine going down. Even the replacement shuts down every once in a while, I suspect it to be from overheating because when I let it sit with the doors open for a while it magically works until it overheats again...
See, I thought this forum was also to report faults, and perhaps for Miller to have another look at the problems. If I had to t-shoot all the brands and report faults to respective tech supports, I'd be one the phone quite a bit. I report it here, and my other thread was terminated, as will this one likely.
I reported it and maybe Miller or Kohler will fix it.
Or simply I'll let it slide. I could have let the New Lincoln Ranger issue slide, And Kohler could have replace hundreds of engines, over and over again. Solved it and the fix is out there. think that the fix just appeared. Someone had to figure it out....
run heat exchanger in the oil pan with a 12 volt electric fuel pump to push the antifreeze through the exchanger and have a 12 volt electric fan radiator.
This stuff is so simple I don't know why I'm not the CEO of Miller....
05-17-2013, 05:30 AM #9Senior Member
- Join Date
- Apr 2012
- Location
- Western Pa.
- Posts
- 335
TB325 issue
I thought that's what all the highly educated engineers were doing. Us real world common folk don't know anything. But like all things the proof is in the field, it works or it doesn't pretty simple.
Sometimes it's as simple as reversing air flow to pull hot air off engine instead of back over it. Or as cruiser said separate it. Ram air has been around long time and it works. But that may be to simple? One thing is sure a engine running to hot or ingesting air that is to hot will not last.
But I'm no engineer. Sorry.
05-17-2013, 07:36 AM #10Senior Member
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- Feb 2012
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- 673
Sounds like a small air to air intercooler, and mounting a small fan on it could work.


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Wake Up, Geek Culture. Time to Die
Posted 09 January 2011 - 12:47 PM
Posted 10 January 2011 - 05:10 PM
Posted 10 January 2011 - 08:15 PM
Posted 10 January 2011 - 11:13 PM
Haven't read it yet, but I've just pulled up a discussion of the essay, among other matters, at NPR.org's "Pop Culture Happy Hour". Hope it's good!
That's where I heard about it. They made me want to read it.
Posted 11 January 2011 - 12:26 AM
Oh, Mr. Oswalt. You are showing your age. For every generation that grows up together, there will be corresponding sub- and counter-cultures. The popular, or "pop" culture gleans it's memes and themes from the sub- and counter-cultures of previous decades. With the internet speeding up the transfer of information, that cycle is faster than it was in the 80s. But trust me, it still exists.
Relatedly, "nerd" and "geek" were relational terms used to refer to certain corners of the 80s and 90s sub-culture. While the labels may still be used today, they may not resonate with you, Mr. Oswalt, growing up as you did in the heyday of the terms.
Those two points established, allow me to STRONGLY disagree with your thesis of the disappearance of otaku. Quite the contrary, I believe that the expansion of the internet has allowed otaku to grow to ridiculous heights. Do you read webcomics? Do you follow any issue-specific blogs? Have you found a channel on youtube that you like? Perhaps one dedicated to recreating the entire starship Enterprise in Minecraft? Have you MET any WoW players? Do you listen to localized hiphop? Have you tried brewing your own beer? Have you visited Etsy? Regretsy? Do you read cheezburger? Do you have the hipstamatic app on your iPhone? Have you read the Hunger Games Trilogy or any other teen dystopia?
Nerds and geeks may be different than when you were a boy, Mr. Oswalt, but otaku is still around. It's just passed you by.
Posted 11 January 2011 - 03:59 PM


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Who said Valentine's Day is just a romantic dinner for deux and a couple's gift exchange? Let's face it: It's your gal pals (and mama, too!) that are there for you when Prince Charming turns out to be the Prince of Darkness. So, since love comes in multiple forms, why not thank the women in your life who warm your heart — and wouldn't dare stand you up for a dinner date.
To help you out, we tapped Jenna Zielbauer, the super-cute designer behind Cotton Candy Couture. Using her sartorial style and general love for all things girly, she's pulled together 10 gifts bound to slap a smile on any gal's face. Seriously, who wouldn't want a personalized bottle of Dom or a DVF clutch? Oh, and if you do have a man in your life, it wouldn't hurt to start dropping a few hints. Click through and start spreading a little love.
Photo: Courtesy of Cotton Candy Couture


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Saturdays, January 26 - March 23
8:45 - 10 am
with Kiku Christina Lehnherr and Dainin Marsha Angus
This class is based on the premise that the heart of Buddha is present everywhere. The development of intention makes it clear that cultivating presence, awareness, openness, mindfulness, kindness and connection are not bound by specific circumstances and environments. Through the lenses of body, emotions and mind, we will be using existing forms and developing new ones that support a sustained practice mind in the midst of our daily activities. Various texts from Zen and other Buddhist traditions will support us in this exploration.
Class fees; eight class meetings: $120; $108 current SFZC members; $96 limited income.
To Register: Use the Ticket Table below. Or call our toll free number 888.743.9362 or local number 415.475.9362.


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- Independent
- The Enterprise
- The Recorder
The is the last week federal workers will be taking a furlough day. It is the last week that their paycheck will be cut 20 percent.
At least until after Sept. 30.
Defense Secretary Chuck Hagel announced Aug. 6 that the 11 scheduled unpaid furlough days, which began in early July, would be trimmed to six. That means that federal workers won't be losing what amounts to another week's pay this summer.
Good news for sure. And if that were the end of it, the workers who will have lost six days pay might even consider themselves lucky. The emergency pay cuts resulting from the budget cuts known as sequestration would be behind them. The Pentagon budget crisis manufactured by a dysfunctional Congress would be over.
Ah, but it may not be over. Congress, which is now in the middle of a five-week recess, has not agreed on a budget for the next fiscal year, which begins Oct. 1.
Who believes that when congressmen and senators return to Washington, D.C., after Labor Day they will buckle down and cooperatively hammer out an agreement for a continuing budget resolution without pushing up to and perhaps beyond the deadline?
Only a sucker would bet the paycheck on that. And who could risk that anyway? Congress is already gambling with the livelihoods of federal workers.
Even if Congress avoids a government shutdown Oct. 1, federal workers at our military bases aren't out of the woods. Unless a larger budget deal replaces it, the next version of sequestration will force the Defense Department to cut an additional $52 billion in fiscal year 2014 — 40 percent more than the $37 billion in cuts required this fiscal year.
Elsewhere in the country, there are those who couldn't care less about the careers and paychecks of federal workers. In places where federal spending is not central to the local economy, it's easy to buy into the caricature of entitled government workers producing nothing but paperwork and red tape. This is why the majority of congressmen seem to have no real interest in replacing sequestration. Their constituents don't see federal workers as real people.
But even those who have no use for the federal government, or think they have no use for it, would know, if they stop and think about it, that arbitrarily cutting nearly $90 billion in defense spending in two years with a meat cleaver instead of a targeted review is not the ideal way to develop military technology and strategy.
A nation weary of war may not be interested in thinking ahead to what it takes to defend the country in the future. But that's the job of many of the people who work at nearby bases.
Congress may be playing into the image many people have of politicians interested in nothing more than gaining ideological and political footing for the next election. That is a self-inflicted wound.
Federal workers don't control their image or their fate. They didn't this summer, and they don't for the next fiscal year.


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Raj Tray
- Overview
Entertain beautifully with our regal Raj collection. The tray is defined by rich wood accents, a pierced rail and hand etching that reveals golden brass under a polished-nickel exterior.
- 15.5" diameter, 2.25" high
- Made of hand-etched brass with a nickel-plated finish, and mango wood.
- Dimensions & Care
- Wipe with a soft dry cloth.
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At Pottery Barn, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction is our priority. We carefully inspect your order prior to shipment. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement. If, within 7 days for Quick Ship upholstery and 30 days for all other products, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value.
We cannot accept returns on monogrammed, personalized, special-order items, or on items damaged through normal wear and tear. We also cannot accept returns of final-sale items which are identified by a price which ends in .99.
For returns of items purchased from your Pottery Barn registry, we will gladly provide a refund or exchange for the merchandise within 90 days of your event or within 90 days of purchase, whichever date is later.
You may return merchandise through the mail for a refund or replacement. For detailed procedures for returning items through the mail, please contact Customer Service at 1.888.779.5176, 7 days a week, 5:00am - 9:00pm (PT).


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aspirin works well to reduce my fever and headache.
it worked to reduce fever
works well for head aches, but not more serious pain
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Celebrate the unique ending to a historic Tour de France! From legendary cycling photographer Graham Watson's gallery collection, this amazing print features a breathtaking look at the peloton under the Arc de Triomphe in Paris, as it arrives not as usual in mid-day, but late in the evening as the sun sets and the lights rise on the Champs Elysees. As Chris Froome rides by front-and-centre, glowing triumphantly in the Yellow Jersey - SNAP! The moment is preserved for all-time, and is now available for your wall. Adding to the majesty of this print is the two-tone effect, in which the entire scene is reproduced in classic black-and-white, with the exception of the peloton's jersey and the massive monument adding a glorious rainbow splash of color. Published on premium-quality gallery stock, reproduced with perfect color and clarity, and designed with an elegant white-bordered layout, this is both a spectacular work of photographic sports art and a great collector's item. A rare look at France's annual cycling showcase, perfect for a nice frame and a prominent place on the wall of any fan! A modern masterpiece from the great Graham Watson.
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The Doobie Brothers are going country -- with a little help from some of Nashville's biggest stars.
Toby Keith, Brad Paisley, Zac Brown Band, Sara Evans, Chris Young, Jerrod Niemann, Love and Theft, and more will be part of a new tribute album to The Doobie Brothers, which will include some of the band's biggest hits.
Paisley and Young performed with The Doobie Brothers in February in Nashville during a private concert for radio executives during Country Radio Seminar.
The album will be released on Sony Music Nashville later this year.


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Williams "expect to be more competitive than last year" as the team heads to Melbourne for the start of the 2013 F1 season...
Williams "expect to be more competitive than last year" as the team heads to Melbourne for the start of the 2013 F1 season...
For all the latest F1 odds on the Australian GP, the opening round of the 2013 F1 Championship, visit Sky Bet.
Pastor Maldonado: "We have been working extremely hard over the winter to improve the performance of the car and we have noticed good potential in the recent tests in Barcelona. I've been involved with the FW35 build since the start of the project in early 2012, working with the engineers, design office and the technicians in the wind tunnel to push for improvements on all fronts. Obviously we don't know what other teams have done and you can only learn so much during testing, but we expect to be more competitive than last year. I like street circuits so I always enjoy coming to Australia and now I just want to start the season and find out where we stand."
Valtteri Bottas: "We have had a good winter at the factory and the car showed strong reliability and performance during testing. The FW35 feels like a new car in comparison to the FW34, behaving and responding differently around the track to the car I was driving on Friday mornings last year and I'm impressed with the improvements the team have made. The winter has seen me preparing hard for the demands of driving a full race which I haven't done before in Formula One. However, I've always done a lot of fitness training and have driven a lot of miles over the past few years with the team, so I'm feeling fully prepared. The first Grand Prix of my career is a big thing for me and I can't wait for the lights to go out in Melbourne and see how the FW35 performs against the competition."
Mike Coughlan, Technical Director: "We had a successful winter test and are continuing to look at all the data we gathered. Following this, we have some further aero tests planned for Friday with both drivers in Australia. The results so far have been interesting and so we'll make our final decision on Friday evening as to what we will run over the weekend. In either case, we feel we have two strong aero packages, each with their own benefits, and so the nature of the circuit and temperatures we find will dictate which package we choose.
"Melbourne is a high power sensitivity circuit, more so than Spa-Francorchamps which is quite surprising. Ambient temperatures can be very high, fuel consumption is high and there is increased brake wear. The ambient temperatures in Jerez and Barcelona are very different to what we expect to find in Australia, so we'll be looking very closely at tyre degradation during practice on Friday. Overall, we are very much looking forward to the start of the season as we have confidence in the FW35."


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The Community of Disc Golfers and About All Things Disc Golf
Over the weekend my 11 year old daughter played in the Green Valley Am Challeng in Yucaipa California. It was an interesting weekend weather wise. It poured rain on us and blew 25-30 mph winds at her all morning. Then in the afternoon the weather got really bad. It got down into the high 30's and hailed on us for about 10 minutes.
At some point during the day, as her caddy, I ran out of dry towels. It was impossible to get a dry disc in her hand. I was shoving them inside my jacket against my sweater to try and get them dry, but both of us where soaked through, even with rain gear on.
Three plastics really seemed to do well, Lat64 Test, Lat64 Opto, and Innova R Pro. We kept going to these discs because they felt the grippiest even when the disc was dripping wet. The Lat Test Plastic felt like a wet suit it was so grippy.
What plastics do you like in foul weather? What towels work the best in the most extreme onditions? How do you stay dry when the wind is driving water through every seeem in your clothes? What other gear does the trick in bad weather?
Views: 243
Disc wise,
In wet weather I prefer D line plastics
Opto seems to work really well in wet weather but not as well as D line plastics
Cold weather,
ESP FLX or any other really soft plastic works really nicely
trash bag style ponchos!!!
Micro fiber or I use a car washing mitt.
Cassidy pretty much nailed it here. Our league will pretty much play in any kind of weather or temperature (then again we are all crazy). I personally go for my Pro D magnets in the wet stuff and stick to my Lat64 Gold plastic for the drives. Star and Z plastic don't hold too well, although my Cryztal Z Stalker seems to holding up well for the past few rain outings. I also like to go with heavier plastic in heavy winds/rains.
Exactly !! Experiment and see what works best for you. For myself , I prefer Dx type of plastic.
yeah the baseline plastic from most disc makers do have a nice grippy feel to em.. too bad they degrade so fast.
They only degrade if you hit anything but grass . . .
car shammy,wipes and rings out well for the rain.stash a couple extra in bag.D line as mentioned.
dx and pro-d (especially) will break in from throwing hard even it doesn't hit anything
any pro plastic is nice, some star/esp discs are grippier than others-same can be said for some of the champion/z...
every disc is different. I think the more ergonomic shapes (buzz, whippet, teebird, magic) help when it's wet
Thanks Mr Ed, there's my golden nugget right there. Using a shammy is a great idea. Even if I use it initially to get most of the water off the disc, it will hellp the terry towel or microfiber stay dryer longer. Plus it wrings out way better than the terry finish towels.
I always find something I can use in these conversations.
I know others have posted it before, but if I know the weather will be severe, I'll stash at least one towel in a ziploc in my bag. That way when the other towels have been soaked through I still have one in reserve. Towels are important because I'm stubborn and don't like swapping out plastics for different weather conditions.
I don't have a shammy, but microfiber is pretty helpful because it rings out well.
© 2015 Created by Terry "the Pirate" Calhoun.


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About AMA Pro Road Racing
AMA Pro Road Racing is the premier motorcycle road racing series in North America and is universally regarded as one of the most competitive road racing organizations in the world. The 2014 schedule includes rounds on many of the country's finest road courses.
The Series is comprised of four production-based classes: AMA Pro SuperBike, AMA Pro GoPro Daytona SportBike, AMA Pro SuperSport and the AMA Pro Vance & Hines Harley-Davidson Series. The performance characteristics of the motorcycles raced in each division are configured with the intent of providing platforms for riders to compete and hone their skills as they climb the ladder to the premier AMA Pro SuperBike division.
SuperBike continues a motorcycle racing legend that began in 1976 and features fast, powerful, large-displacement motorcycles based on a rule set that allows for a variety of performance modifications. Traditionally considered a 1000cc class, the rule structure has been updated to provide a platform for additional big-bore motorcycles to compete within the same performance envelope. Nine different brands were represented on the SuperBike grids in 2012: Yamaha, Suzuki, Kawasaki, Honda, BMW, Buell, EBR, KTM and Ducati.
The carefully designed rule package for GoPro Daytona SportBike provides a platform for motorcycles with different engine configurations to compete on even ground and since the class debuted in 2009, it has become known for extremely close racing and a great depth of field. Due to the parity in performance, it is not uncommon to see packs of 10 motorcycles from five or more different brands battling for the lead in every turn. GoPro Daytona SportBike is also the featured class in America's premier endurance motorcycle road race, the DAYTONA 200.
SuperSport is the proving ground for AMA Pro's up-and-coming motorcycle talent. The rules allow riders to select from the same diverse set of machines that are eligible for competition in Daytona SportBike, but with fewer modifications. A special award highlighting the younger SuperSport riders is given to the highest-points-scoring 16- to 21-year-old rider.
The Vance & Hines Harley-Davidson Series made its debut halfway through the 2010 season, bringing with it the return of one of the most evocative names in motorcycling: Harley-Davidson. Using the Harley-Davidson XR1200 modified with a specially-prepared parts-and-accessories kit from famed motorcycle performance tuner Vance & Hines, riders can race the big twins on the national stage in a cost-contained manner that emphasizes rider skill.
On a traditional three-day event weekend, each of AMA Pro Road Racing's three sport-performance classes, AMA Pro SuperBike, GoPro Daytona SportBike and AMA Pro SuperSport, have their first practice and qualifying sessions on Friday afternoon. Grids are set following Saturday morning's final qualifying session, and each class is featured in sprint races on both Saturday and Sunday afternoons. The schedule for the Vance & Hines Harley-Davidson Series is similar; The big twins have practice and qualifying sessions on Saturday afternoon before battling it out in a single sprint race on Sunday afternoon.
In addition to watching the thrilling on-track action, fans are invited into the AMA Pro Road Racing paddock and garage areas to meet the stars of the sport and to watch as the crew chiefs and mechanics work on the machines.
Most AMA Pro Road Racing events feature grid walks during opening ceremonies before the races on Saturday and Sunday. Fans can casually stroll on the surface of some of America's finest race tracks while getting autographs, talking with riders and viewing race-prepped motorcycles positioned along the pit wall.
Track walks are also offered at select venues on the schedule, giving fans an opportunity to get up close and personal with AMA Pro riders as they walk the circuit following a day of competition. Event promoters further add to the experience by providing additional options for the fan agenda, including fan parties, vendor areas, manufacturer demo rides, motocross and BMX stunt exhibitions, street stunt riders, live music, fireworks and more.


text: After years of working his way through the Turkey youth national team ranks, Batuk finally made his debut with the senior side in the EuroBasket 2013 Qualification Round - albeit with just 16 scoreless minutes in two games. But the 23-year-old is part of Turkey's strong 1990 generation. The shooting guard has good scoring skills and is a weapon from beyond the three-point arc. Batuk has also shown he is ready to take on more responsibility. He played two seasons in EuroChallenge with Pinar Karsiyaka before moving to Euroleague side Anadolu Efes Istanbul, where he proved last year in his first campaign that he can contribute to a top-level club. If he makes the team for Slovenia, Batuk will benefit greatly from serving as a back-up to veterans like Sinan Guler and Omer Onan.