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Life science and pharmaceutical representatives from throughout the country converged Wednesday in Annapolis to testify on a bill that would regulate how pharmacies could provide substitutes for biologics — the new wave of complex compounds developed by biotechs to treat diseases from arthritis to cancer.
Senate Bill 781, introduced by Sen. Joan Carter Conway (D-Dist. 43) of Baltimore, is similar to one being considered in several states. It would regulate the dispensing of biosimilars, which are so-called "generic" versions of brand-name biologics, which are derived from living proteins. Most conventional drugs are created without proteins and are more easily, and cheaply, replicated by generic drug-makers.
Likewise, generic versions of conventional drugs are more easily produced than biosimilar versions of biologics.
The bill had its hearing in the Senate Education, Health and Environmental Affairs Committee, which Conway chairs.
Representatives of several Maryland biotechs, including MedImmune in Gaithersburg, backed the bill during Wednesday's hearing. MedImmune is the biologics division of AstraZeneca. Human Genome Sciences in Rockville, acquired last year by GlaxoSmithKline, also develops biologics.
The Tech Council of Maryland, represented by Brian Levine, described the bill as "pro-industry."
The proposal would allow pharmacies to dispense substitutes for biologics only if they have been approved by the Food and Drug Administration as interchangeable with the prescribed biologic and if the prescribing physician does not limit treatment to the biologic. The bill also would require that patients be notified in writing that the biosimilar is interchangeable and that prescribing physicians be notified within five business days of the substitution.
The first biologic patent expires in 2014, paving the way for a biosimilar substitution, said Amy Dempster, senior manager of state government affairs for the mid-Atlantic region of biotech giant Genentech of South San Francisco. She said the industry is concerned about the ability to track the effects of biosimilars if multiple substitutions occur.
But Brynna Clark, director of state affairs for the Generic Pharmaceutical Association, said interchangeable biosimilars that would be approved for substitution face more rigorous federal vetting than other biosimilars and would probably not be ready as early as 2014, making the bill premature.
Some state organizations, including the Maryland Pharmacists Association, agreed, given that the FDA has yet to approve any biosimilars, although the authority to establish an approval pathway was included in the federal Patient Protection and Affordable Care Act.
"I think when they do come out, they can be handled like generic drugs are handled today," said Howard Schiff, executive director of the trade group. "This is too restrictive to be put into law."
Schiff said last week that while regulations might be necessary when biosimilars first hit the market, any problems should sort themselves out within the first year.
Clark said the bill places "onerous burdens" on pharmacies, and biosimilars could save Marylanders as much as half of the $24.7 million that Medicaid spent on biologics in 2011 in the state.
She urged the committee to wait until the FDA develops its guidance before imposing what she called a "chilling effect" on biosimilar developers.
The precautions the bill focuses on might be addressed by this future guidance, said Jill McCormack of the National Association of Chain Drug Stores.
Others argued that the bill is not premature and that its provisions will protect patients.
"We believe whether a biological should be substituted should be decided by the physician and the patient," said Allen Todd, a Silver Spring resident who uses biologics to manage his diabetes. Todd also is part of the Global Healthy Living Foundation, a New York nonprofit advocacy organization focusing on chronic illness.
Gene Ransom, CEO of the Maryland State Medical Society, or MedChi, said recently that the bill is not premature because biosimilars already are used in Europe.
"It doesn't take too much of a leap to realize this is happening soon," Ransom said. "It's always good to have rules in place beforehand."
Ransom said his group supports the bill because members want to ensure treatments will not be switched without proper physician and patient notification. He said the proposed policy is consistent with what is included in pharmaceutical drug policies.
"It protects the patient. This is not like switching out a chemical. This is a living compound," Ransom said. "This decision should not be made by some insurance company trying to save money by using a biosimilar."
This bill is "critical" because it establishes guidelines for dispensing biosimilars instead of just having a patchwork of rules in 50 states, Douglas Doerfler, vice chairman of the Tech Council of Maryland, said in an email to The Gazette. Doerfler also is CEO of MaxCyte, a Gaithersburg biotech that provides cell transfection systems.
"The complexity of biologics will invariably lead to some differences between the biosimilar and the innovator product and such differences could lead to clinical differences," he said. "SB781 establishes criteria for safe substitutions and streamlining the substitution process, which is vitally important in reducing costs and creating a framework and pathway that will ensure patient safety."
Doerfler also pointed out Conway's bill has no negative fiscal effect and said it might be fiscally positive for the state by streamlining the process. A fiscal note attached to the bill indicates the measure would have minimal effect.
"If a problem develops and the doctor does not know what product their patient is taking, there will be added costs," Doerfler said, adding that the bill allows pharmacists time that works with their schedule to contact the prescribing physician.
Conway was not available for comment.
Legislative committees have approved biosimilar regulation bills in Virginia, North Dakota, Indiana and Florida, some with amendments. Mississippi has rejected a similar bill.


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UNO has been awarded the 2014 Presidential Award for the Economic Opportunity category.
This award, presented by President Barack Obama, recognizesinstitutions with service programs that build economic independence,increase family stability, and create more sustainable and resilientcommunities.
Institutions applying in this category will be engaged in service thatimproves the financial well-being and security of economicallydisadvantaged individuals.
Learn more about UNO's award-winning programs.
A student-led program created to organize and coordinate university-wide service and volunteering opportunities.
Browse current and upcoming volunteer/service opportunities, sign up to volunteer, and join the UNO Serve mailing list.
Have a passion for social change? Work with the Clinton Global Initiative University or start a seed project.
Learn more about how you and local nonprofit organizations can help our community.
Contact Us
Civic & Social Responsibility
6001 Dodge St
Community Engagement Center
Room 130
Omaha, NE 68182

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AM Inspiration: Decapitated Giants, Glamour Ground into Sand
Following up on Tuesday's post about Africa's environment reflected in poetry, here's another installment, this time about deforestation. While the word might conjure up associations with the Amazonian rainforest, deforestation is actually an acute problem in Africa. Unlike in Latin America, an e...
Tags: Africa, Biodiversity, Cooking, Deforestation, Solar, Tree


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ERC Latvia pure engine sound
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—Jim Laub
To appreciate the significance of Utah State University's new membership in the Mountain West Athletic Conference is to understand the five decades of Aggie sports history preceding it.
When several universities formed the Western Athletic Conference in 1962 and excluded Utah State, it sent the Aggies on an odyssey that included 18 years of NCAA independence and memberships in the PCAA/Big West and Sun Belt Conferences before finally joining the WAC in 2005.
Equally important to the story is the school's unwavering leadership at a time in 2010 when the WAC began to weaken, leadership that insisted Utah State set its sights on stability in its conference affiliation.
Intercollegiate alliances like these always benefit more than just departments of athletics and USU President Stan Albrecht and Vice President and Director of Athletics Scott Barnes realized that as they carried out their plan to shepherd Utah State to higher ground.
We all know the end result: USU officially joined the 15-year old Mountain West July 1 of this year.
But a look back at the work Albrecht and Barnes did during a critical 21-month period from August, 2010 to May, 2012, when USU accepted the official MWC invitation, explains how the Aggies arrived in the new conference ready to make their mark.
Pres. Albrecht describes some of it as "serendipity," issues out of his control.
But there is much more to the story.
The changing landscape of intercollegiate athletics was apparent by the middle of 2010 as the Aggies were preparing for their sixth season of competition in the Western Athletic Conference.
Albrecht was chair of the WAC Presidents Council at a time when Boise State announced plans to leave the WAC for the Mountain West. He and the council knew to keep their conference strong would require a proactive approach as schools all over the country were jumping from one league to another.
Brigham Young University's decision during that time to become independent in football meant it needed a conference affiliation for its other sports.
Under Albrecht's leadership the WAC presidents invited BYU to bring those sports into the Western Athletic Conference and administrators in Provo were open to the invitation but sought assurances there would be no more defections to further weaken the WAC.
An agreement was forged to strengthen the alliance among the remaining schools but when Fresno State and Nevada left to join Boise State, the WAC's future as a football-playing conference was in jeopardy.
That is when Albrecht and Barnes stepped back and examined not only the future of the WAC but of their aspirations for USU athletics.
To keep the league viable WAC leaders focused on a search for other football-playing institutions. The USU administration was fully invested in that effort.
At the same time Albrecht and Barnes re-examined their five-year football excellence plan and judged it was on target as a result of Coach Gary Andersen's hiring in 2009. Also, they prepared to advance the Aggies into an unknown future confident of the nation's respect for Stew Morrill's basketball success.
With a focus on needed facilities improvements, they took the conversation to important supporters of the program.
"Jim Laub (CEO, Cache Valley Electric) was absolutely key to this," said Albrecht, "with his willingness again to invest in USU athletics."
It was Laub's continuing generosity that led to the building of the 69,000-square foot athletics and academics complex in Romney Stadium's north end zone .
It bears Jim and Carol Laub's name and is the centerpiece of USU's commitment to facilities growth. It changed the Aggie landscape.
Albrecht knew, though, as important as Laub was he couldn't carry the Aggies on his back alone; others would have to be willing to help.
"That has happened big time and it's been absolutely essential to where we are," said Albrecht.
Utah State dealt successfully with questions of campus facilities and concerns about access to what some regarded as the school's remote northern Utah location.
Albrecht and Barnes were convinced if they could persuade those of influence in the Mountain West to visit the USU campus, the school would sell itself.
They were right.
"We needed to have them come and look and hopefully get beyond past perceptions that may have been holding us back. We wanted them to see the reality of Utah State University today," said Albrecht.
The core qualities of the university came into focus for MWC Commissioner Craig Thompson on his first visit to Logan. Albrecht said the Mountain West's decision-makers realized how well USU fit into the conference.
Some of the serendipity, Albrecht mentioned, came into play when San Diego State and Boise State announced plans to leave the Mountain West for the Big East Conference. Thus, the MWC was again considering new members.
By then, the Aggies had positioned themselves with new facilities, plus commitments to construct a strength training center and a basketball practice venue with donated funds, in addition to a campaign of education that answered the prevailing questions about USU.
Utah State was ready.
"At the end of the day, after they visited Logan, the academic quality of our institution shone forth," said Albrecht. "They became familiar with how forward-looking this institution is.
"Our entire campus community can take pride in understanding the role it played in our invitation to join the Mountain West," said Albrecht.
The Aggies also scored points as the Mountain West sought to create a geographically based conference, a logical approach that has been lost in other expansion stories around the country.
For example, the San Jose trip was the Aggies' nearest league football road game last fall; it will be the longest conference trip the team will make this season.
"Dr. Albrecht and Scott Barnes have been phenomenal through this process," said Commissioner Thompson. "Certainly they can't control things like market size and wins and losses. But their vision, plus the new facilities and the commitment to athletics and the successes, particularly in the two most visible sports of football and men's basketball, perhaps set them above the rest.
"The campus in Logan feels and looks like a number of our other places — Wyoming and Colorado State, another land-grant university, for example — and it did not hurt that their academics go right to the top of our league. It is just a great fit," Thompson said.
Barnes is convinced the Mountain West Conference got it right with expansion this time.
"We're now aligned with like institutions and re-connecting with regional rivals that go back decades," he said. "This absolutely changes our trajectory to grow in athletics and as an institution."
During the two-year period leading to the MWC invitation, Albrecht kept a busy schedule, not the least part of which was the school's very successful comprehensive campaign. At the same time, in building support for USU's candidacy athletically, he maintained contact with friends in key administrative positions in the west and throughout the nation.
"Through this entire process, I can't emphasize enough the importance of Scott Barnes' involvement," said Albrecht. "His respect among fellow athletic department leaders and his contacts in intercollegiate athletics were invaluable."
Not surprisingly, there is a restlessness
in the Aggie Nation, which refuses to regard membership in the new league as the end-all achievement in the school's 125-year history.
Aggie junior quarterback Chuckie Keeton said student-athletes have followed the news with excitement.
"We know we're moving up and we're definitely trying to make our name known as being a great program, not just having a good season or a good two seasons. We're trying to leave a legacy as a great program."
"USU is in great hands right now," said Jim Laub, an Aggie fan since his youth. "This is our golden age, not only for athletics but for the university as a whole. That doesn't mean we've peaked. I think our greatest years are ahead of us.
"President Albrecht has provided unmatched leadership. Our leadership, both athletically and across the board, has been second to none in my experience."
— Craig Hislop '72
Photo GalleryMouse over thumbnail for detail
The invitation to join the Mountain West Conference brings smiles to USU's Pres. Stan Albrecht
and Vice President and Director of Athletics Scott Barnes.
Chuckie Keeton
Kyle Mckenna
Jennifer Flynn
Paige Jones
Preston Medlin
Chari Hawkins
Jennifer Schlott


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En español | For every adult who heard the childhood warning Drink your milk or you won't have strong bones, Jeri Nieves has another message. "It's never too late to take care of your skeleton," says Nieves, director of bone density testing for the Clinical Research Center at New York's Helen Hayes Hospital.
See also: Join AARP's Online Community to share healthy recipes and fitness tips.
"Think of it as a bank account," Nieves says. "You were putting calcium into the account when you were younger to accumulate, and now that you're older, you're mostly looking to maintain what you have." To do that, she says, people age 50 and over may need to increase their consumption of some foods and beverages, and cut back on others.
"We want people to get the amount of calcium recommended for them but not necessarily to exceed it," says Nieves. Too much calcium, she says, may contribute to ailments such as kidney stones, prostate cancer and heart disease. For women over age 50, that's about 1,200 milligrams a day. Men need 1,000 milligrams a day up to age 70, and 1,200 milligrams a day from age 71 on. Good sources include:
- Low-fat dairy foods.
- Leafy green vegetables such as kale, collard greens and broccoli rabe,
- Calcium-fortified products, including soy milk and juices.
- The calcium content of many dishes, from puddings and baked goods to stews and soups, can be increased by about 50 milligrams for every tablespoon of nonfat dried milk added to a recipe.
Nieves counsels consumers to estimate their daily calcium intake from foods generally, and then take only enough calcium supplements to hit their recommended dietary allowance (RDA).
For example, Nieves says, "If you start every day with calcium-fortified orange juice and have yogurt for lunch, you could already be getting 800 milligrams of calcium and you can simply add another serving of a high calcium food to get your required amounts. (The National Osteoporosis Foundation has a worksheet that can be used to calculate the calcium in a consumer's daily diet, and the organization Osteoporosis Canada has a "calculate my calcium" tool online.)
Vitamin D
This vitamin helps the body absorb calcium, so getting enough of it every day is vital, Nieves says. While it is found in fatty fish such as salmon, tuna and halibut, most people will need to supplement their diet to get their RDA — 600 international units (IU) a day up to age 70, 800IU a day for those 71 and older. By reading food labels, consumers can choose foods that have been fortified with Vitamin D, and then can take a supplement to round out their RDA. Going a little over the requirement isn't a problem, she says, as a person would have to consume about four times the RDA of Vitamin D to do yourself any harm.


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Where can I find instructions on registering?
Click here for registration instructions.
How do my donations help?
With the generous support of people like you, the American Lung Association in California saves lives by fighting for healthy lungs and healthy air. Today, our fight is more important than ever. Eighty-one cents of every dollar raised by our organization goes directly to education, research and advocacy.
What is Fight for Air Walk?
The Fight fir Air Walk is a community event intended to raise funds and awareness for the American Lung Association. Generally, our events are 3.1 miles (five kilometers) in length and some people walk the distance and other run. There are usually shorter walk options on event day for those who are unable to complete such a distance. Walks are being held nationwide in an effort to bring attention to this devastating chronic disease. We know a lot about lung disease, but there is so much we don't know. Your participation will raise the funds necessary to provide life saving education, research and advocacy so we can beat lung disease and soon find a cure.
What time should I be there?
Registration will open at 8 AM and the walk will begin at 9 AM.
Where should I park?
Parking is available onsite at the store.
Where is the start line?
The store will serve as both the start and finish line.
What is a team captain?
Being a team captain is easy. Captains gather together a few friends or family members and encourage them to participate in the event together. Each team captain helps to coordinate the online registration of these friends as well as setting a goal for the team overall. Team Captains should encourage their participants to personalize their fundraising pages, send e-mails to other friends and family, hit their overall goals, show up to the event and have a great time. Some team captains organize gatherings before or after the walk for their team members, but this is not required. Sometimes the team captain serves as a representative at the annual event kickoff luncheon. In short, we need help to rally the troops and the best people for the job are always our team captains.
How far is the walk?
The full walk is 5k, with a shorter route available which is approximately 1.5 miles.
What do I bring with me on the day of the event?
Please bring any fundraising dollars you have collected and not yet turned in. Please bring a roster of your team members if you are the captain as well as how much each person raised if not already online. You may wish to bring a bottle of water and wear sunscreen depending on the conditions for the day, but most importantly, please bring a positive attitude and lots of energy!
Are pets allowed?
Unless otherwise specified because of unique restrictions at our location, pets are encouraged if on a leash.
How do I sign up?
You can register online by clicking here or you can call our office and register over the phone during normal business hours at 909-321-3290.


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Please fill out the form to request up to 7 swatches. Samples take approximately 2-3 business days for delivery. All fields required.
If you can fold, you can be organized. From flat to fabulous in no time. Each piece is available in gun metal, fire engine red and white. Think of it as functional origami without papercuts.
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text: series: Census of Population and Housing, 1980 [United States] Series > Study Search Results Your query returned 1 results. Results per page: 25 50 100 Sort by: Title A-Z Released/Updated Time Period Most Cited in ICPSR Bib. (?) Study Title/Investigator 1. Census of Population and Housing, 1980 [United States]: P.L. 94-171 Population Counts (ICPSR 7854) United States Department of Commerce. Bureau of the Census [1]


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Monday, January 21, 2013
Bucs conclude tournament 15-4 in singles, 6-3 in doubles
WINSTON-SALEM, N.C. (Jan. 21, 2013) – The ETSU women's tennis team finished off the Wake Forest Winter Classic on Monday, taking five-of-six singles matches from Radford while winning a doubles contest against Elon.
For the three days combined, the Buccaneers head back to Johnson City having gone 15-4 against the singles competition and 6-3 in doubles. Those marks include a 6-0 sweep of Wake Forest in singles on Sunday, and a 2-1 victory over the Demon Deacons in doubles on Saturday.
"It was a pleasing three days of tennis," ETSU assistant coach Travis Sandlant said. "We let an opportunity slip this morning on No. 1 doubles, but credit to Elon and its fight. To come away with the results we had this weekend is a great start to the year and something to build on."
The opportunity that slipped Monday morning saw two regionally ranked doubles pairs square off on court one. Elon's Jordan Johnston and Frida Jansakar – No. 10 in the Carolina Region – took on Anna Gerbasi (Caracas, Venezula) and Lyn Yee Choo (Kuching, Malaysia) – No. 8 in the Ohio Valley Region – with the Phoenix duo winning the set, 8-5. The other two doubles matches were split, with the Buccaneers winning in a tiebreak at No. 2, while Elon won decisively at No. 3.
Following the doubles session, ETSU went up against Radford in singles to conclude the three-day festivities, taking five matches in convincing fashion. Senior newcomer Antonia Kolovou (Larisa, Greece) won at No. 2 against Hana Babic, 6-1, 6-1; Gerbasi defeated Taylor Newman, 6-2, 6-2; Choo cruised by Meg Napolitano, 6-2, 6-1; junior Salma Dahbi (Marrakech, Morocco) rolled by Taylor Fay, 6-2, 6-1; finally, sophomore Kelsey Williams (Sunbury, Australia) took care of Allison Michaels, 6-0, 6-4. Junior Giulia Andreazza (Balneario Camboriu, Brazil) lost a close one with Gemma Valls in the top match, winning the first set and ultimately dropping the match tiebreak, 4-6, 7-5, 1-0 (10-5).
ETSU next takes the court for its dual opener, scheduled for Sunday, Feb. 3, in Murfreesboro, Tenn., against MTSU.Wake Forest Winter Classic – Day 3 Results Singles vs. RadfordNo. 1 – Gemma Valls def. Giulia Andreazza – 4-6, 7-5, 1-0 (10-5)No. 2 – Antonia Kolovou def. Hana Babic – 6-1, 6-1No. 3 – Anna Gerbasi def. Taylor Newman – 6-2, 6-2No. 4 – Lyn Yee Choo def. Meg Napolitano – 6-2, 6-1No. 5 – Salma Dahbi def. Taylor Fay – 6-2, 6-1No. 6 – Kelsey Williams def. Allison Michaels – 6-0, 6-4 Doubles vs. ElonNo. 1 – Jordan Johnston/Frida Jansakar def. Anna Gerbasi/Lyn Yee Choo – 8-5No. 2 – Antonia Kolovou/Giulia Andreazza def. Bryn Khoury/Taylor Casey – 8-7 (7-4)No. 3 – Viviana Stavreva/Barbora Lazarova def. Sofia Espana/Salma Dahbi – 8-2
ETSU fans wanting Buccaneer news, score updates, in-game promotions and much more sent to their mobile device can do so by signing up for "Buc Updates." Click here to sign up today!
For more information on ETSU women's tennis, please visit www.ETSUBucs.com.
|Copyright ©2015 East Tennessee State Athletics. All Rights Reserved.


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Chicago sports fans, this is one of the most breathtaking images you will ever see! With the full skyline of the Loop in the background, this incredible poster features Chicago Bears gameday at pre-reconstruction Soldier Field, as it stood before reopening in 2003. From the beautiful neo-classical facade on the outside, to the packed stands inside, it's all here, in all its glory, for your wall! Perfect for the wall of any Bears fan who will appreciate the new look, but remember fondly the good old days, of football at grand old Soldier Field. Note: matching poster available featuring New Soldier Field - click here to view New Soldier Field "From Above".
Product Specifications:


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Description:64MB Cache module onlyfor Smart Array 5I PlusSpare Part# 260741-001For DL380 G2264030-B21 = 274402-001 (board)+ 260740-001 (battery) + 260741-001 (64MB Cache)For ML370 G2263697-B21 = 274400-001 (board)+ 260740-001 (battery) + 260741-001 (64MB Cache)
Overview:The ProLiant Cluster HA/F100 for MSA1000 kit is designed to assist in simplifying the configuration of cluster solutions that provide the highest level of data and applications availability in the Windows Operating System environment through clustering to provide no-single-points -of-failure. This kit does not include HP SecurePath multipath software.
Part Number260741-001
Products ID141324


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Some revolutionaries wear Guy Fawkes masks and talk about the 1 percent, and some revolutionaries wear suits and talk about policy thresholds. Chicago Fed President Charles Evans is one of the latter.
A year ago, Evans was the rare dovish dissenter at the Fed. He didn't think it was taking the unemployment half of its dual mandate seriously enough, so he proposed a new, eponymous rule for it to do better. He certainly wasn't the first Fed president to have his own ideas about monetary policy, but a funny thing happened on his way to heterodoxy--his ideas quickly became the consensus. Now, just a year later, the Fed has fully embraced the so-called Evans Rule by linking interest rates to the unemployment rate.
Ain't no revolution like a monetary policy revolution.
It's been a brave, old world for central banks the past four years. Short-term interest rates have been stuck at zero, which, outside of Japan, hasn't happened since the 1930s. It's what economists call a liquidity trap, and it means central banks can't stimulate growth like they normally do by cutting short-term interest rates. They can't cut below zero. This doesn't mean central banks are powerless, just that they have to try new things.
These new things come in two varieties: promises and purchases. Central banks can pledge to hold short-term rates at zero even after the recovery accelerates, or they can buy long-term bonds to push down long-term rates; the former is what Paul Krugman calls "credibly promising to be irresponsible" and the latter is what we call "quantitative easing." These sound like big changes from standard operating procedure, but the goal with both is the same as normal--to reduce interest rates. It's just harder to do in a liquidity trap. Central banks have to increase expected inflation to lower inflation-adjusted rates when nominal, that is headline, rates are at zero. That's the point of these promises and purchases, and that's been the point of the Fed saying it expects to keep rates at zero through mid-2015 and buying $85 billion of mortgage and Treasury bonds a month. But as much as the Fed has done, there's still much more it can do--such as making its promises more explicit--which it started to do with its latest policy move. Let's break it down into two pieces.
The Fed's big announcement was that it won't raise rates before unemployment falls to 6.5 percent or inflation rises to 2.5 percent. Notice the word "before" here. The Fed won't automatically raise rates if unemployment or inflation hits one of these thresholds, but it won't do so until at least then. These are the exact thresholds Evans endorsed a few weeks ago, which are modest tweaks from hisoriginal thresholds last year of 7 percent unemployment and 3 percent inflation.
Why all the fuss? This Evans Rule doesn't seem to tell us anything the Fed wasn't already telling us. Just look at the Federal Open Market Committee's latest economic projections. The Fed doesn't think unemployment will fall below 6.5 percent until 2015--and it never thinks inflation will rise above 2 percent--which implies rates will stay at zero until then. That's exactly what they were saying before.
In truth, the Evans revolution is less a revolution itself and more a significant step on the way to the actual revolution: NGDP targeting. We'll come back to this larger point, but first let's talk about why the Evans Rule matters. Its virtue is it should make the Fed's decision-making more transparent, and that should affect people's expectations more. Contrast the Evans Rule with what the Fed told us before--say from October--about how long zero interest rates would last.
[The Fed] currently anticipates that exceptionally low levels for the federal runds rate are likely to be warranted at least through mid-2015.


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Tuesday, April 06, 2004JOHNSON CITY, Tenn. (April 6, 2004) - Struggles on offense and an opportunistic Radford squad made for a perplexing combination as the East Tennessee State University softball team dropped a pair of games in a non-conference doubleheader Tuesday at Metro-Kiwanis Park. The Highlanders, behind complete-game shutout efforts from pitchers Jennifer Bosley and Breanna Felix, swept the twinbill 6-0 and 3-0. With the wins, Radford improved to 22-23 overall, while the Lady Bucs dropped to 21-20. In the first game, Radford scored a single run in the top of the second inning on a triple by Colleen Casey and a RBI single from Danielle Tompkins. In the top of the fourth, the Highlanders exploded for five runs thanks to three hits, a pair of walks and an ETSU error. For the game, Tompkins and Sara Beth Clayton collected a pair of RBIs, while Casey and Amanda Walling each had two hits apiece. On the mound in game one, Bosley got the win by going the distance and allowing only six hits. ETSU's Courtney Jenkins (2-6) suffered the loss. For the Lady Bucs, left fielder Rhea Holler (Peoria, Ariz.) and shortstop Mary Beth Hazelwood (Knoxville, Tenn.) were the lone bright spots with two hits apiece. In game two, Radford got all the offensive production it would need in the top of the third inning. With three-straight singles off the bats of Lara Wohlgemuth, Lindsay Wood and Sara Beth Clayton, the Highlanders loaded the bases. A walk to Ashley Smith brought home one run and then a two-out, two-run single by Casey did the rest of the damage. Felix was strong on the mound, going all seven innings and allowing just three hits. For ETSU, Belinda Barerra (Fayetteville, N.C.) took the loss at dropped to 8-9 on the season. The Lady Bucs will return to Southern Conference play on Friday when they travel to UNC Greensboro for a doubleheader beginning at 1 p.m. ETSU will then face the Spartans in a single game on Sunday. Meanwhile, Radford returns to action on Wednesday at home against Appalachian State, with first pitch set for 4 p.m.
|Copyright ©2015 East Tennessee State Athletics. All Rights Reserved.


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Product Reviews / Main Nibbles / Jams, Jellies & Nut Butters
Harvest Song Preserves
Armenian Preserves From Mt. Ararat
CAPSULE REPORT: When there's a chill in the air and the days are shorter, one can find consolation in the fruits of the fall harvest. Harvest Song's old-style European preserves, using recipes from the days when sugar was used sparingly, are imported from Armenia, where farmland and labor are still affordable. That means a large jar is just $8.00. And unlike the same old, same old, there are interesting variations not easily found here.
The complete Harvest Song review is below. If you'd like to try your own hand at preserves and pickled walnuts, here are some excellent books.
Singing In The Harvest: Harvest Song Preserves
There are people who enter the specialty food business through special callings. James Tufenkian, founder of Tufenkian Artisan Carpets, is the world's leading designer and supplier of Armenian and Tibetan rugs. An American of Armenian grandparentage, he wanted to use his business skills to help Armenia's economic revival. Harvest Song Ventures, his year-old company with co-founder and native Armenian Sylvia Tirakian, introduces indigenous Armenian products to the United States. At the 2006 Summer Fancy Food Show®, their Apricot Preserve was chosen as Outstanding Jam, Preserve, Spread or Sweet Topping by the NASFT* jurors among all entrants in the show.
*The National Association of Specialty Food Trades, NASFT.org, presents the Fancy Food Shows uniting manufacturers of specialty foods with retail buyers and distributors. Map of Armenia from the Central Intelligence Agency's World Factbook, public domain.
The Republic of Armenia, a former Soviet Republic, is landlocked in the southern Caucasus mountains. If one knows Armenia only by its preserves, one can't help but envision a beautiful country where the land yields magnificent fruit—the way fruit used to be grown in our own country, before it was hybridized to be shelf-durable at the expense of flavor. You can visualize the proud Armenian farmers bringing in the harvest, and farm wives making small batches with recipes handed down through generations. You don't need printed material to paint the picture. With just one taste, your eyes open wide and you see the whole history of these amazing preserves. One wants prosperity for Armenia, but not the kind that produces so many of the indistinct products made on our own shores.
The story becomes even more melodious when one discovers that Harvest Song Foods are grown in the valley of Mount Ararat (photo at right), with bubbling springs and a history as old as the Book of Genesis. The twin-peaked Mt. Ararat (their outline is used in the company's logo) is said to be where Noah's Ark came to rest when the Great Flood receded, between the Great Peak and the Little Peak. The fruit in Harvest Song preserves has an exceptional past: according to the Bible, Noah descended from Mount Ararat and planted the very first fruit tree. Amid broad green pastures and expansive meadows covered in multicolored wildflowers, the fruits are grown at 1400 to 1800 meters above sea level, in pure air. The fertile land and clear spring waters give Armenian fruit a lush and succulent taste—you'll notice it from your first spoonful of preserves.
The Flavors Of Harvest Song
With thirteen varieties, one has to start somewhere. Here are our favorites.
Quince Preserves. Quince is a tough fruit to deal with, literally and figuratively. That's why it's not often found on these shores. It can't be eaten raw, and thus loses in economic popularity to fruits that can multitask. But that makes finding anything quince a greater pleasure. The taste of cooked quince is plum married to rose (quince is a member of the rose family)—not floral but sophisticated and masculine rose. This preserve is more jam-like: quince must be made workable in a purée. Small pieces of fruit, not necessarily visible to the eye, add texture. Dark caramel in color, it can be used as a spread, as a dessert sauce on ice cream, on a pate sandwich with foie gras mousse or chicken liver mousse, with cold poultry sandwiches, as a condiment on a plate with hot poultry, with waffles or pancakes. No matter how you use it, quince is a prince.
Walnut Preserve. These walnuts are preserved, but they're not a jam. They're whole, cooked, spiced nuts. It is not easy to find preserved walnuts—they're a specialty of Armenia and Scandinavia, where they're enjoyed with cheese. The preserved walnuts look like small plums: dark and gleaming. The taste is very special: the texture is like fruit, the flavor is spiced. They evoke the idea of the British sugarplum, which is a small, sugary candy but should be something more special, like this. No lover of fine foods should pass these up. They make a very special gift to food-loving friends. Make ice cream with them—cut them into pieces and mix them into vanilla, fig or caramel ice cream—or simply use them as topping.
Cheese Condiments
Like fruit pastes (the classic Spanish membrillo and others), preserves make wonderful pairings with cheese. You can read our extensive article on cheese condiments and cheese and condiment pairings, but here are some specific suggestions for Harvest Song, chosen by New York's cheese restaurant and cheese shop, Artisanal Fromagerie And Bistro. As with anything, do your own experimenting.
The large jars (18.9 ounces) encourage you to eat your fill. The tops are decorated in sun-dried rice paper from Katmandu, in the colors of the harvest—russet, green-gold and earth tones.
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G-G-GREAT movie
G-G-GREAT movie
To Change Your Heart
The pictures at the end had me rolling. Especially the last sequence. One of my favorite parts of the movie, which overall was hilarious.
New sig coming soon!
Not nearly as good as everyone hyped it up to be. The pictures at the end were quite funny though. I don't think it was even close to as good as several of the recent Apatow films (I Love You, Man and Forgetting Sarah Marshall) and it's not even in the same league as Old School or Wedding Crashers.
"I told the team 7-9 is mediocre, and mediocrity is not going to be accepted here" - Tony Sparano
"Well the cool breeze came on Tuesday, And the corn's a bumper crop
And the fields are full of dancin' Full of singin' and romancin'
The music never stopped." - Bob Weir
Just finished watching it. Didn't laugh once. And i've seen a lot of funny movies. What a complete waste of time. Should've just watched troll2 again. Now that's a funny movie!
Lip Balm?
pretty damn amusing. that movie was just like one of the ones we used to rent in high school purely for the ridiculous factor. i can't think of any off the top of my head right now but they'll come to me.


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Mission Type: Lander
Launch Vehicle: 8K78 (no. R103-25)
Launch Site: NIIP-5
Spacecraft Mass: c. 1,470 kg
Spacecraft Instruments: 1) imaging system and 2) radiation detector
Deep Space Chronicle: A Chronology of Deep Space and Planetary Probes 1958-2000, Monographs in Aerospace History No. 24, by Asif A. Siddiqi
Yet another Soviet attempt to soft-land a Ye-6 probe on the lunar surface ended in failure when the Blok L upper stage failed to fire for the translunar injection burn. Instead, the spacecraft remained stranded in Earth orbit.
A later investigation indicated that there had been a short circuit in an inverter within the I-100 guidance system of the spacecraft (which also controlled the Blok L stage) preventing engine ignition. The spacecraft's orbit decayed five days later.


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Cameraman Ganga Tho Rambabu
Action/Adventure, Romance
Rambabu is a hot blooded journalist. Ganga, who is a technician of a TV channel, asks Rambabu to join her office after he investigates two big wars between two student gangs about cast system. Meanwhile, Ranababu enters politics, following in his father's footsteps. Rambabu gets into a fight with Ranababu. What happens next will form the crux of the story.
Cast: Prakash Raj, Brahmanandam, Pawan Kalyan, Kota Srinivasa Rao, Tamannaah Bhatia
Produced by:
Directed by: Puri Jagannath
Written by: Puri Jagannath
Running time: min
Opens: Oct 17, 2012 Limited
|Theaters for Today
Pick a day
on this day.


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Modulation of mGlu3 (mGlu3_GIRK_Schild)
The hippocampus is a limbic cortical structure that plays an important role in a number of normal physiological processes and is a primary site of pathology in certain neurological disorders, such as Alzheimer's disease and temporal lobe epilepsy (see (Brown and Zador 1990) for review). Because of its important role in both normal and pathological processes, a great deal of effort has been more ..
Tested Compounds
Tested Compounds
Tested Substances
Tested Substances
Related BioAssays
Related BioAssays
Tested Compound:
Related Experiments
The hippocampus is a limbic cortical structure that plays an important role in a number of normal physiological processes and is a primary site of pathology in certain neurological disorders, such as Alzheimer's disease and temporal lobe epilepsy (see (Brown and Zador 1990) for review). Because of its important role in both normal and pathological processes, a great deal of effort has been focused on developing a detailed understanding of the cellular mechanisms involved in regulation of transmission through the hippocampal circuit. Evidence suggests that the metabotropic glutamate receptors (mGlus) play a variety of roles in modulating transmission and cell excitability at each of the major excitatory synapses in the hippocampus (Anwyl 1999; Coutinho and Knopfel 2002). In particular, the Gi/o-coupled group II mGlus (mGlu2 and mGlu3) can have significant physiological effects in the hippocampus. Activation of group II mGlus reduces transmission at perforant path-dentate gyrus synapses (Macek et al. 1996), the mossy fiber synapse (Nicholls et al. 2006), and at synapses onto certain interneuron populations (Doherty et al. 2004). However, although presynaptic group II mGlus do not directly reduce synaptic transmission through actions on glutamatergic terminals at the SC-CA1 synapse (Gereau and Conn 1995b; Winder et al. 1996; Fitzjohn et al. 1999), we and others previously reported extensive studies demonstrating that group II mGlus in this region are involved in a novel form of glial-neuronal communication. In particular, activation of group II mGlus induces a marked potentiation of cAMP responses elicited by activation of beta-adrenergic receptors (betaARs) in astrocytes, leading to release of adenosine from the astrocytes and inducing a profound depression of transmission at the SC-CA1 synapse via activation of presynaptic A1 adenosine receptors (Winder et al. 1996; Moldrich et al. 2002). This unique response provides a mechanism by which activation of group II mGlus only reduces transmission at the SC-CA1 synapses under conditions where betaARs and group II mGlus are coincidentally activated. This could provide a protective mechanism to reduce risk of excitotoxicity during periods in which there is excessive excitatory drive when noradrenergic inputs are highly active, such as during periods of intense or prolonged stress.
Unfortunately, despite concerted efforts by multiple groups, selective reagents that differentiate between mGlu2 and mGlu3 have not been available to allow determination of the specific mGlu subtype involved in modulating betaAR-mediated cAMP responses and effects on synaptic transmission. However, within our mGlu5 program, we have discovered compounds with mGlu3 NAM activity, such as VU0092273 (Rodriguez et al. 2010), that have excellent aqueous solubility and achieve high CNS exposure. However, this compound also acts as an mGlu5 PAM. While the mGlu5 PAM activity prevents use of VU0092273 as a selective mGluR3 NAM probe, discovery of this compound still represents a major breakthrough in that it is the first compound that selectively blocks mGlu3 relative to mGlu2 and establishes the feasibility of optimizing novel molecules that act at mGlu3 without effects on the closely related mGlu2 subtype. Thus, it will now be critical to further optimize compounds based on VU0092273 that are selective for mGlu3 relative to all other mGlu subtypes. Establishing novel, highly selective mGlu3 probes represents a critical need that could directly impact our understanding of mGlu3 function and could have a major impact on the direction of current drug discovery efforts focused on discovery and development of agents that activate or inhibit group II mGlus.
This unique response provides a mechanism by which activation of group II mGlus only reduces transmission at the SC-CA1 synapses under conditions where betaARs and group II mGlus are coincidentally activated. This could provide a protective mechanism to reduce risk of excitotoxicity during periods in which there is excessive excitatory drive when noradrenergic inputs are highly active, such as during periods of intense or prolonged stress. However, it is also possible that this reduction in transmission at a key hippocampal synapse could impair hippocampal function and could contribute to the known disrupting effects of stress on hippocampal synaptic plasticity and cognitive function (Howland and Wang 2008). If so, selective antagonists of the specific group II mGlu subtype that mediates this response also have potential utility as cognition-enhancing agents. Consistent with this, while non-selective group II mGlu agonists can reduce stress responses (Swanson et al. 2005) these agents also impair hippocampal-dependent cognitive function (Higgins et al. 2004). While speculative, this hypothesis provides a critical impetus for determining the specific group II mGlu subtype responsible for this response and establishing the impact of selectively blocking this receptor on hippocampal function.
Compounds will be initially screened by performing concentration-response curves (CRCs, 10 points, ranging from approximately 30 uM-1 nM at 0.3% final DMSO concentration) to determine the potency and efficacy of novel compounds for mGlu3 in a thallium flux assay measuring coupling of mGlu3 to G Protein-coupled Inwardly Rectifying Potassium (GIRK) Channels (Niswender et al. 2008; Jin et al. 2010; Dhanya et al. 2011). Compounds with IC50 values less than 1 uM will next be evaluated for potency versus mGlu2 in a thallium flux CRC assay. Compounds demonstrating at least 20-fold selectivity for mGlu3 versus mGlu2 will then be evaluated for the mechanism of mGlu3 antagonism through Schild functional thallium flux assays at mGlu3 to determine if the compounds are antagonizing mGlu3 in a competitive or noncompetitive manner. For noncompetetive compounds passing the above steps, we will pursue follow-up studies to determine their selectivity for mGlu3 relative to other mGlu subtypes. Our goal for this project would be to generate an mGlu3-selective compound, with an IC50 under 1 uM, and with reasonable solubility in a solvent generally useful for in vitro experimentation (i.e., DMSO). The ultimate goal of this project from the PI's perspective is to generate compounds that would be useful proof-of-concept molecules to determine the mGlu subtype involved in glial-neuronal communication in the hippocampus.
1. Anwyl, R. (1999). "Metabotropic glutamate receptors: electrophysiological properties and role in plasticity." Brain Res Brain Res Rev 29(1): 83-120.
2. Brown, T. A. and A. M. Zador (1990). Hippocampus. The Synaptic Organization of the Brain. S. GM. New York, Oxford UP: 346-388.
3. Coutinho, V. and T. Knopfel (2002). "Metabotropic glutamate receptors: electrical and chemical signaling properties." Neuroscientist 8(6): 551-61.
4. Dhanya, R. P., S. Sidique, et al. (2011). "Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats." J Med Chem 54(1): 342-53.
5. Doherty, J. J., S. Alagarsamy, et al. (2004). "Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus." J Physiol 561(Pt 2): 395-401.
6. Fitzjohn, S. M., A. E. Kingston, et al. (1999). "DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists." Neuropharmacology 38(10): 1577-83.
7. Gereau, R. W. t. and P. J. Conn (1995b). "Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability." J Neurophysiol 74(1): 122-9.
8. Jin, X., S. Semenova, et al. (2010). "The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats." Neuropsychopharmacology 35(10): 2021-36.
9. Macek, T. A., D. G. Winder, et al. (1996). "Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses." J Neurophysiol 76(6): 3798-806.
10. Moldrich, R. X., K. Aprico, et al. (2002). "Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures." Neuropharmacology 43(2): 189-203.
11. Nicholls, R. E., X. L. Zhang, et al. (2006). "mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses." Proc Natl Acad Sci U S A 103(16): 6380-5.
12. Niswender, C. M., K. A. Johnson, et al. (2008). "A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors." Mol Pharmacol 73(4): 1213-24.
13. Rodriguez, A. L., M. D. Grier, et al. (2010). "Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity." Mol Pharmacol 78(6): 1105-23.
14. Winder, D. G., P. S. Ritch, et al. (1996). "Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus." J Physiol 494 ( Pt 3): 743-55.
Panel Information
mGlu3 Schild Assay - The effect of multiple concentrations of test compound on a glutamate dose response
§ Panel component ID.
mGlu3 GIRK Schild
Culture of the rat mGlu3 GIRK cell line
HEK/GIRK cells stably expressing the M4 muscarinic receptor and rat mGlu3 were grown in 45% Dulbecco's Modified Eagle Media (DMEM), 45% Ham's F12, 10% fetal bovine serum (FBS), 100 units/ml penicillin/streptomycin, 20 mM HEPES (pH 7.3), 1 mM sodium pyruvate, 2 mM glutamine, 600 ng/ml puromycin dihydrochloride (Sigma-Aldrich) and 700 ug/ml G418 (Mediatech, Inc., Herndon, VA). (Growth Media). Cells for experiments were generally maintained for approximately 15-20 passages. All cell culture reagents were purchased from Invitrogen Corp. (Carlsbad, CA) unless otherwise noted.
Schild Protocol
Cells were plated into 384 well, black-walled, clear-bottom poly-D-lysine coated plates (Greiner) at a density of 15,000 cells/20 uL/well in DMEM containing 10% dialyzed FBS, 20 mM HEPES, and 100 units/ml penicillin/streptomycin (Assay Media). Plated cells were incubated overnight at 37 degrees C in the presence of 5% CO2. The following day, plated cells had their medium exchanged to Assay Buffer (Hanks Balanced Salt Solution (Invitrogen) containing 20 mM HEPES pH 7.3) using an ELX405 uplate washer (BioTek), leaving 20 uL/well, followed by addition of with 20 uL of 330 nM FluoZin-2 AM (Invitrogen, Carlsbad, CA) prepared as a 2.85 mM stock in DMSO and mixed in a 1:1 ratio with 10 percent (w/v) pluronic acid F-127 and diluted in Assay Buffer for 1 hour at room temperature. The dye was then exchanged to Assay Buffer using an ELX405, leaving 20 uL/well and the plates were incubated at room temperature for 10 min prior to assay. Test compounds were prepared in DMSO, and transferred to daughter plates using an Echo acoustic plate reformatter (Labcyte, Sunnyvale, CA), and diluted into Assay Buffer to generate a 2x stock. Glutamate concentration-responses were diluted in Thallium Buffer (125 mM sodium bicarbonate (added fresh the morning of the experiment), 1 mM magnesium sulfate, 1.8 mM calcium sulfate, 5 mM glucose, 12 mM thallium sulfate, 10 mM HEPES, pH 7.3) at 5x the final concentration to be assayed. Thallium flux was measured using the Functional Drug Screening System 6000 or 7000 (FDSS6000 or FDSS7000, Hamamatsu, Japan). Baseline readings were taken (10 images at 1 Hz, excitation, 470+/-20 nm, emission, 540+/-30 nm) and then 20 uL/well of test compounds or vehicle were added using the FDSS's integrated pipettor. Approximately 2.5 minutes later 10 uL of Thallium Buffer +/- a concentration-response of glutamate was added. After the addition of glutamate, data were collected for an approximately 3 additional min.
Thallium sulfate requires special handling and disposal precautions and investigators are cautioned to contact their Environmental Health and Safety Department to ensure proper procedures are followed.
Data analysis
Data were analyzed using usoft Excel. Raw data were opened in Excel and each data point in a given trace was divided by the first data point from that trace (static ratio). For experiments in which antagonists/potentiators were added, data were again normalized by dividing each point by the fluorescence value immediately before the agonist addition to correct for any subtle differences in the baseline traces after the compound incubation period. The slope of the fluorescence increase beginning five seconds after thallium/agonist addition and ending fifteen seconds after thallium/agonist addition was calculated. Curves were fitted using a four point logistical equation using XLfit (IDBS, Bridgewater, NJ). Subsequent confirmations of concentration-response parameters were performed using independent serial dilutions of source compounds and data from multiple days experiments were integrated and fit using a four point logistical equation in GraphPad Prism (GraphPad Software, Inc., La Jolla, CA. The log of the dose ratio will be calculated and linear regression performed to determine if responses are consistent with competitive (orthosteric) or noncompetitive (allosteric) interaction.
Compounds showing a Schild slope significantly different from unity (1.0) will be assigned 'Mechanism' = 'Allosteric'.
Result Definitions
** Test Concentration. § Panel component ID.
Additional Information
Grant Number: R01 NS031373


text: (iPhone not included) (iPad not included) Back dock detail With remote (iPad not included) Photos (5) Video View larger Arcam rSeries drDock iPod®/iPhone®/iPad® dock with built-in DAC Item #: 776DRDOCK 7 Reviews This item is no longer available. Original Price: $299.99 Shop all iPod Docks Need help? 1.888.955.6000 Email Chat Ask an expert advisor No pressure, no commission — just lots of good advice from our highly trained staff. Overview Reviews Details Staff Reviews Articles & Videos by Ralph Graves Provides a sturdy base for an iPad. A dock that really delivers Get the highest quality audio and video from your Apple portable with the Arcam rSeries drDock. This sturdy, aluminum-cased dock can accommodate your iPhone, iPod, or even iPad. When connected, the dock bypasses the digital-to-analog converter (DAC) inside your player, and feeds pure, unprocessed digital data to be its own built-in high-performance DACm, which provides more accurate, musical sound. Exceptional audio and video The drDock has a pair of RCA analog stereo outputs, so you can plug it into your home theater receiver or desktop speaker system and enjoy great sound. Does your system already have an outstanding DAC of its own? Then use the drDock's coaxial digital output and let your DAC do its thing. And if you want to enjoy video from your docked player, the drDock has an HDMI port so you can run uncompressed video to your HDTV for the highest quality image possible. An important part of the Arcam ecosystem The drDock comes with its own remote, so you can use it with just about any make of audio/video equipment. But it's also designed for use with Arcam's own line of impressive components. You can use the drDock with the Arcam Solo Mini compact stereo receiver, making it even more versatile. Or couple it with the Arcam Solo Neo Internet radio receiver. Both of these devices let you control the drDock through their own remotes. Pass-through syncing The drDock's power adapter has a USB plug, so you can either connect it to a wall outlet, or connect it to your computer via a USB port. Using the USB connection lets you conveniently sync your docked player. Product Highlights:compatible with docking iPods, iPhones, and iPadsbuilt-in DAC (digital-to-analog converter) bypasses player's DAC for improved sound qualityHDMI video output for connecting to a TVcoaxial digital audio output for connecting to an external DACstereo RCA analog outputRS232 control inputsturdy cast aluminum caseUSB port for power and syncingAC power adapterremote control4"W x 2-1/2"H x 4-3/8"Dwarranty: 1 yearOur 60-day money-back guarantee Arcam rSeries drDock Reviews Average Customer Review: 7 reviews Review this product Submit a review and then enter to win a $350 rewards card Filter by rating: 5 Star: (0) 4 Star: (0) 3 Star: (0) 2 Star: (0) 1 Star: (0) Review this product: Thanks for taking the time to share your experiences about this product. Please be sure to focus your comments on the product itself. Read our Review Guidelines for more information. Review title * Email Your email won't be visible. Please use the email address that is associated with your order. Display name (e.g., JohnD) Your review will be signed using the display name and location * Your location (e.g., Charlottesville, VA) * Your rating Click on a star to rate the overall product on a scale of 1-5 1500 characters left * Your review Attach a YouTube Review Crutchfield Video Review Guidelines Only submit videos that you made or are authorized to use. Do not submit videos that contain music, video or visuals that are copyrighted and belong to someone else. Please see our Review Guidelines for more information. Enter the URL of your YouTube™ video review or product demonstration. e.g., "http://www.youtube.com/v/o79TWHh598U" 500 characters left Pros 500 characters left Cons * Agree to Terms By checking this box you agree your review becomes the property of Crutchfield, that you are over 18 years of age, that you own or have owned this product, and that you are located within the United States or its territories. Please see our Review Guidelines for more information. We reserve the right (but are not obligated to) review all submissions and edit or remove any review in any manner which we deem necessary. Your review should be posted within seven days. Arcam drDock Written By Shawn, Princeton, NJ on Monday, September 01, 2014 Crutchfield Customer Review (What's this?) While it may appear a bit pricey, I feel it is worth the price. Thanks to this docking station, I can enjoy music from an ipod, which I never could unless in a car. Pros: Excellent sound Was this review helpful? Yes No Arcam dr dock Written By T R, Maine on Friday, January 03, 2014 Crutchfield Customer Review (What's this?) Great product. To have both stereo and coax outputs is a real plus. It makes my iPod sound just fine through my system. Pros: Coax and stereo outputs, great size and easy to hook up. Cons: None 1 out of 1 people found this helpful Was this review helpful? Yes No Transforms IPod Written By RoyM, Florida on Wednesday, January 23, 2013 Crutchfield Customer Review (What's this?) This little gem unleashes your iPod/Pad. Excellent construction as well. Highly recommended. Has a ton of features I have not even explored. 4 out of 4 people found this helpful Was this review helpful? Yes No dr dock Written By mfoster, Midland TX on Monday, January 21, 2013 Crutchfield Customer Review (What's this?) equipment-Balanced Audio Technology VK3i Pre-amp Cary CAD 805 tube mono block amps B&W Nautilus 805 speakers Synergistic Research Resolution Reference cables Benchmark DAC Review- When I first hooked it up, I played the Rolling Stones GRRR I had downloaded from Itunes just using the inrnal dac. I was not impressed. The volume was low and the sound was lifeless. so then I ran it through my Benchmark dac1. Wow it came to life and sounded almost as good as any cd I had. Huge wide soundstage coming deep from behind the speakers, open midrange and good tight bass. I would recomend if you get one of these have a good external dac. That's the only reason I gave it 4 stars instead of 5. I would buy it again. Pros: Gray product easy to hook up Cons: poor internal dac 4 out of 6 people found this helpful Was this review helpful? Yes No Arcam drDock does a good job on performance and flexibility with both Written By Masterpiece & Premium, Douglas, Arizona on Thursday, October 25, 2012 Crutchfield Customer Review (What's this?) The drDock may be a niche product, but its good performance and flexibility with both music and video make it a great partner for your system. The supplied remote remains a tiny rectangle with buttons that are intuitively placed, but rather awkward to use. You can use it to flick between the menus on your iPod/iPhone, but the controller isn't very responsive, and can be frustrating when manipulating the slicker interface of your iDevice. The simple versatility of the updated connections makes the drDock easy to use. Streaming stored movies or YouTube videos from your device to your TV is steady and uninterrupted; standard-def picture quality is relatively decent, with HD videos faring better with cleaner picture. While i wish some of the menu controls or the iPad's interface were displayed on your TV screen instead of staying blank when a video isn't playing, it's nevertheless a great way to watch movies as a group rather than huddling around an iPad. Switch to playing music, and the drDock does a fine job of fitting in with existing hi-fi systems. There's enough attack and detail across the frequencies to make the drDock sound authoritative and solid, and the instruments are well separated within a fairly open soundfield. All this makes the soaring music sound exciting and dramatic - turn the volume on your amp up and you'll find the drDock stays in control of the music when things get demanding. Pros: Strong sound with good detail and dynamics; updated connections for better quality; can play videos from iDevices on TV; iPad compatible; good build It might look like an unassuming product, the drDock is a versatile and capable digital dock - and if you're an Apple user, it would be a great addition to your existing hi-fi system. Cons: Remote control is frustrating to use; it's not cheap 3 out of 4 people found this helpful Was this review helpful? Yes No Makes iPod A Hi-Fi Audio Source Written By Al, Lancaster, OH on Saturday, October 20, 2012 Crutchfield Customer Review (What's this?) Thanks to my friends and the public library, my 80GB iPod has over 17,000 songs. It never really sounded good enough to use as a hi-fi source using the headphone jack to RCA connectors. I did have a lot of songs on it that I didn't have on disc that I wanted to hear again. I had some Crutchfield Rewards Points and decided to give the Arcam rSeries drDock a try. It sounds great! This makes a big difference in sound quality. The highs are better, bass is full, imaging is much improved, and finally there is some air in these digital recordings. It makes my 128kbps files sound like CD's. Pros: All in one unit, no need for a separate dock and DAC. Small size, can share shelf space with other components. Solid build and feel, rubber on the bottom so it stays in place on the shelf. It recharges the iPod as it plays. When people come over, the iPod can shuffle for hours with true hi-fi sound! Cons: none 5 out of 5 people found this helpful Was this review helpful? Yes No Arcam drDock Written By RickA, Omaha, NE on Sunday, July 15, 2012 Crutchfield Customer Review (What's this?) I was looking for a dock to use with my Cambridge Audio integrated amp and had seen a lot of good press regarding the Arcam drDock. After checking with several high-end audio dealers in Omaha, I found that no one here had it in stock. So I ordered it from Crutchfield. The dock arrived quickly, and is a wonderful addition to my stereo system. The sound is incredible, the dock is small enough to fit neatly inside my audio cabinet, and it is very well made. I could not be happier with this purchase. 5 out of 5 people found this helpful Was this review helpful? Yes No Hands-on research What's in the box? | In-depth notes What's in the box? Download owner's manual iPod/iPhone/iPad dock AC power supply (with attached 58" DC cord terminated by a USB type-B connector) 3 AC adapter plugs (US/UK/EU) Remote control (CR1) CR2025 Lithium 3V battery (installed in remote) 48" USB cable (with a USB type-A connector on one end a a USB type-B connector on other end) 48" Stereo RCA cable 48" Control cable (with a RS232 connector on one end and a 3.5mm connector on other end) Connections/Quickstart Guide Thank You letter Product Research Features Overview: The Arcam drDock is an external add-on dock for iPod, iPhone, and iPad which can be connected to your home stereo system via analog stereo RCA or digital coax; as well as to your TV via HDMI. The drDock uses audiophile grade components and design techniques to deliver the best possible sound quality. An IR remote is included for wireless operation of your docked Apple device. Aluminum Chassis: The Arcam drDock features high-quality cast aluminum construction for optimum RF shielding. iPod Dock Connector: The Arcam drDock features an integrated top-panel iPod dock to connect your compatible iPod, iPhone, or iPad. The drDock supports audio playback, video output, remote control, syncing, and charging of your docked Apple device. Analog & Digital Output: The drDock supports audio playback of your docked iPod/iPhone/iPad's stored music podcast, or audiobook files; as well as music apps when connected to a stereo or home theater receiver, via analog stereo RCA or digital coax (the dock's HDMI output does not support audio playback from audio only sources). HDMI Output: In addition to playing audio, the drDock can output video from supported iPods, iPhones, and iPads. Video playback from a compatible Apple device is possible via the drDock's HDMI output. When a video-enabled iPod/iPhone/iPad is docked and playing, audio/video is routed to the dock's HDMI terminal and output to your connected television. The unit's HDMI output only supports audio/video output from a video file stored on your iPod/iPhone/iPad, or from select video apps (such as YouTube & Netflix). Output of metadata, menus, or various applications is not supported. Note: Audio is not output from the HDMI terminal for audio only sources. You will need to connect either the dock's analog or digital audio output to your home stereo when listening to audio only sources. Wireless Remote Control: The Arcam drDock comes with an IR remote control (CR1) for wireless operation of your docked iPod, iPhone, or iPad. The remote can be used to navigate through menus and tracks on your docked Apple device and change its play mode (repeat/random). You can also continue to operate your iPod/iPhone/iPad from its clickwheel or touchscreen. The remote operates off of a single CR2025 3V "coin-type" lithium battery (included). Menu Navigation: You can navigate through the menus of your docked iPod, iPhone, or iPad to find your music by Playlist or Category (Artist, Album, Song, Genre, Composer, etc.). Basic Playback: The IR remote provides Play/Pause, Fast-Forward/Rewind, and Skip (previous/next) playback functions. Play Modes: You can switch between Repeat (track, playlist/folder) and Random (playlist/folder) playback modes. Note: The supplied remote can be used to control your iPod, iPhone, or iPad when the drDock is not connected to a supported Arcam product. If you are using the drDock with a supported Arcam product, use the Arcam system's remote instead (see Control Port below). Control Port: The drDock features 3.5mm Control Port and includes a 48" minijack-to-RS232 cable to connect the Arcam Solo Mini Music system (776SOLMINI, sold separately) or the Arcam Solo Neo Stereo Receiver (776SOLONEO, sold separately). This allows your iPod/iPhone/iPad's track information to be displayed on these Arcam systems. Battery Charging: The Arcam drDock charges your iPod, iPhone, iPad while connected through its external AC power supply. Sync: The drDock is fitted with a USB (type-B) port and comes with a 48" USB cable which allows you to sync your docked iPod, iPhone, or iPad with your PC or Mac. This USB connection can also be used to charge your iPod or iPhone (but not your iPad). You must unplug the dock's external AC power adapter and place the drDock in Sync mode (you will not be able to playback your iPod/iPhone/iPad while syncing is in progress). iPod/iPhone/iPad Compatibility Chart: The Arcam drDock is "Made for iPod/iPhone/iPad" compatible and supports the following iPod, iPhone, and iPad model features (as of 7/4/2012): iPod/iPhone/iPad Model Generation Tested Version Media Type Control Type Display Type Charge Audio Video Out Remote iPod/iPhone/iPad Song/Artist Text Track Info dock connector 3rd N/A N N N N N N N clickwheel color 4th N/A N N N N N N N mini 1st N/A N N N N N N N 2nd N/A N N N N N N N video 5th N/A N N N N N N N classic 80GB 1.1.2 Y HDMI Y Y Optional Optional Y 120GB 2.0.1 Y HDMI Y Y Optional Optional Y 160GB 2.0.4 Y HDMI Y Y Optional Optional Y nano 1st N/A N N N N N N N 2nd 1.1.3 Y N Y Y Optional Optional Y 3rd 1.1.3 Y HDMI Y Y Optional Optional Y 4th 1.0.4 Y HDMI Y Y Optional Optional Y 5th 1.0.2 Y HDMI Y Y Optional Optional Y 6th 1.1 PC Y N Y Y Optional Optional Y touch 1st 2.2.1 Y HDMI Y Y Optional Optional Y 2nd 4.2.1 Y HDMI Y Y Optional Optional Y 3rd 5.0.1 Y HDMI Y Y Optional Optional Y 4th 5.1.1 Y HDMI Y Y Optional Optional Y iPhone 2G 3.1.3 Y HDMI Y Y Optional Optional Y 3G 4.2.1 Y HDMI Y Y Optional Optional Y 3GS 4.3.5 Y HDMI Y Y Optional Optional Y 4 5.1.1 Y HDMI Y Y Optional Optional Y 4S 5.1.1 Y HDMI Y Y Optional Optional Y iPad 1 5.1.1 Y HDMI Y Y Optional Optional Y 2 5.1.1 Y HDMI Y Y Optional Optional Y Note: Apple iPod/iPhone software updates may change functionality results. If you download a newer software version, you may need to reset the device and your iPod/iPhone to regain functionality. If this doesn't work, you may need to wait until a newer software update is available. External AC Adapter: The Arcam drDock includes an external 5V switching power supply (100-240V). The drDock also includes three interchangeable AC plugs (US/UK/EU). Input: 100-240V ~ 50/60Hz, 0.5A Output: 5.0V - 2500mA Our Product Research Team At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team. They verify what's in the box, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices. Product reviews from the Crutchfield Labs Impressive build quality Written by Ralph Graves, Staff Writer - Creative, on 7/5/2012 11:08:00 AM To try out the drDock in the Crutchfield Labs, I made a very simple setup. I connected the drDock via RCA cables directly to a pair of AudioEngine A5+ bookshelf speakers. Then In docked my iPhone and fired up Pandora® Internet radio. First, I was impressed by the build quality of the dock. It had a metal casing, and felt quite substantial. This was a rock-solid base that could easily support an iPad (as its designed to do). Online music services don't have the best sound quality, but the DAC inside the drDock made the most of the signal it was getting. Of course, listening through a pair of high-performance speakers helped too, but I heard well-balanced, natural-sounding music with plenty of detail. Even at low volume levels, the sound remained clean and well-defined. What are the Labs? Sorry, the Arcam rSeries drDock is no longer available. Looking for a similar item? Shop all iPod Docks Or, you can still... Write a review Download the product manual Search the website Go


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does anyone know where or how to get copies of 808 state shows from sunset radio, from the early 90's?
Ive been searching the net for some time with no luck.
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Clark County Senior Affirmation Event (Borden Jr-Sr High School)
21st Century Scholars who are high school seniors are strongly encouraged to attend a senior affirmation event. At each event, a 21st Century Scholars representative will provide important information about how to activate and maintain eligibility for the 21st Century Scholarship.
This event is open to all 21st Century Scholars who are Borden Jr-Sr High School seniors. A representative will meet with students during the school day.
Location: Borden Jr-Sr High School
Date: Feb. 1, 2013
Time: 9:30 a.m.


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What [eco] Is[eco] encourages, tracks and rewards on air, online and on location engagement through a comprehensive strategy operating within a single database. Only one login for the station, cluster and group.
Where [eco] Is[eco] is proven. Market after market [eco] attracts more radio listening, more web traffic, more non-spot revenue than any listener engagement product on the market.
Why [eco] Works[eco] is one registration, one username, one password and one login for the station, the cluster and group.
How [eco] Measures[eco] provides ratings and research with applications that drives accountable TSL and research with large in-tabs.
What [eco] Generates[eco] provides new local and national non-spot revenue
What [eco] Combines[eco] is accountability with experience.
What [eco] Reveals[eco] provides an apples to apples measurement on creativity and productivity, station to station,cluster to cluster and within the group.
[eco] is more than a marketing plan, more than a promotion, and much more than a feature for your website. Eco is a system for radio's future.
Engagement. Rewards. Accountability.On-Air | Online | On Location
The New Radio Eco system. All the Parts Relate to the Whole. One Database - One Login. Accountable Tune-in; Social Networking; Streaming; Mobile; Music Research; E-commerce; Rewards; Local and National Non-Spot Revenue.


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Protecting your windows from the sun with a window awning is the ideal solution to keep your motorhome or caravan cool.
You will be directed to the official Thule Trailers website. If you're not automatically redirected within 5 seconds, please click here.


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Find a Ricoh Dealer
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Main Features
General Features
Move from job to job quickly. The SP C240SF produces copies and prints up to 16 pages-per-minute for both full-color and black-and-white documents.
Expedite printing and manage multiple jobs easily with a powerful 400 MHz controller and 256MB RAM.
Offer convenient access for shared use in growing offices with standard networking— including IPv6 support—and an optional external wireless Ethernet adapter.
Capture, edit and send information instantly. A full suite of Scan-To document distribution capabilities allows users to leverage existing infrastructure to improve document-related processes.
Send faxes anywhere at the fastest available speeds with a 33.6 Kbps Super G3 Modem, built-in desktop PC faxing, Internet fax, 200 speed dials, authorized and paperless fax reception and more.
Share information easily with a strategically placed USB port located on the front of the system. This gives users advanced Scan-to-USB functionality and convenient access for printing images from a digital camera using PictBridge™ software.
Enjoy near-instant readiness with first print speeds of less than 14 seconds and a warm-up time of less than 30 seconds.
Replace the standard yield All-In-One print cartridges in seconds with a convenient top-loading design.
Create high-quality color business documents. True 600 x 600 dpi and interpolated resolutions up to 2,400 x 600 dpi meet even the highest image quality demands.
Optimize toner usage with Economy Color Mode, limiting the amount of toner used on images and graphics to reduce color output costs.
Capture true quality with full-color and monochrome TWAIN/WIA scanning at up to 1,200 x 1,200 dpi optical resolution and 19,200 x 19,200 dpi driver resolution.
Accommodate more media with thick paper support up to 42 lb. Bond/83 lb. Index— for sizes up to 8.5" x 14"—from both the Standard and Bypass Trays.
Preserve space with a footprint of less than 20 inches for incredible functionality while using minimal desk or counter space.
Add paper without increasing the footprint. An optional 500-sheet Paper Feed Unit can be installed beneath the MFP to bring system capacity to 751 sheets and offer instant access to letter- and legal-size sheets.
Enhance workflow with the standard 35-sheet Automatic Document Feeder. Users can scan originals as large as 8.5" x 14" without placing it on the platen glass to expedite multi-page copying, scanning and faxing.
Minimize filing space and postage costs with standard automatic duplex printing.
Protect information—and your budget. Access to system functions and page volume limits can be set with User Restriction controls. Using Locked Print can help secure confidential information.
Monitor the system in real-time, remotely. Web Image Monitor offers immediate access to supply status and print network settings.
Engine Specification
Part #
Imaging Process
Laser beam scanning & electrophotographic printing with monocomponent 4-drum tandem method toner development
Reading Element
Flatbed with CCD array image sensor
Print Resolution
600 x 600 dpi (Speed mode)
1200 x 600 dpi equiv. (Standard Mode)
2400 x 600 dpi equiv. (Fine Mode)
Print Speed
16 ppm/cpm B&W and Full-Color (Letter)
Copy Speed
16 ppm/cpm B&W and Full-Color (Letter)
First Print Speed
14 seconds or less
Warm-Up Time
30 seconds or less
Operating Systems
Windows XP/Vista/7/Server 2003/ Server 2003R2/Server 2008 (32 bit/ 64 bit)/Server 2008R2 (64 bit); Mac OS X 10.3 – 10.6; Citrix MetaFrame, UNIX (using Ricoh UNIX filter)
Software Utilities
Web Image Monitor, Presto! PageManager
Engine Specifications
Standard Paper Capacity
250-sheet Paper Tray + 1-sheet Bypass Tray
Optional Paper Feed Unit
500-sheet Paper Feed Unit
Maximum Input Capacity
751 sheets
Output Capacity
150 sheets (face down)
Paper Sizes
Standard & Bypass Tray: Letter (8.5" x 11"), Legal (8.5" x 14"), EXEC (10.5" x 7.25"), Half Letter (5.5" x 8.5"), A4 (8.3" x 11.7"), A5 (5.8" x 8.3"), A6 (4.1" x 5.8"), B5 JIS (7.2" x 10.1"), B6 JIS (5.0" x 7.2"), F (8" x 13"), Foolscap (8.5" x 13"), Folio (8.25" x 13"), 16 Kai (7.6" x 10.5") Envelopes: Com10, Monarch, C5, C6, DL Custom size: Min. 90 mm x 148 mm (3.6" x 5.92"), Max. 216 mm x 356 mm (8.64" x 14.24") Opt. Paper Feed Unit: Letter (8.5" x 11"), A4 (8.3" x 11.7")
Paper Weight
Standard and Bypass Tray: 16 – 42 lb. Bond/83 lb. Index (60 – 160 g/m2) Optional Paper Feed Unit: 16 – 28 lb. Bond (60 – 105 g/m2)
Media Type
Std. and Bypass Tray: Plain Paper, Middle Thick, Recycled Paper, Envelopes, Thick Paper, Labels, Thin Paper, Color Paper, Prepunched Paper, Letterhead, Bond Paper, Card Stock, and Preprinted Paper (Std. Tray only) Optional Paper Feed Unit: Plain Paper, Middle Thick, Recycled Paper, Thick Paper, Thin Paper, Color Paper, Preprinted Paper, Prepunched Paper, and Letterhead
Dimensions (W x D x H)
16.5" x 19.4" x 18.7"
(420 x 493 x 476 mm)
66.2 lb. (30 kg or less) (including consumables)
Power Requirements
120V, 60Hz
Max Power Consumption
1300W or less
Energy Saver Mode
10W or less
Safety Regulations
UL60950-1 2nd Edition, CAN/CSA C22.2 No. 60950-1 (c-UL)
Printer Specifications
Printer Languages
RAM Memory Capacity
256 MB RAM standard/maximum
USB 2.0, 10/100Base-TX Ethernet, USB Host Interface for PictBridge™
Optional Interfaces
*IEEE 802.11b/g Wireless
*Please note the Wireless Option and 10/100Base-TX cannot operate simultaneously.
Network Protocols
TCP/IP (IPv4, IPv6), IPP, Bonjour
Copier Specifications
First Copy Speed
30 seconds for both B&W and Full-Color
Copy Resolution
600 x 600 dpi (Platen)
600 x 300 dpi (ADF)
Quantity Indicator
1 – 99
Multi-Copy Speed
16 cpm B&W/10 cpm Full-Color
Original Type
Sheet/Book/3D Objects
Original Size
Up to 8.5" x 11.7" (Platen);
Up to 8.5" x 14" (ADF)
25% – 400% in 1% increments
Reduction Ratios
50%, 65%, 78%, 93%
Enlargement Ratios
129%, 155%, 200%, 400%
Copier Features
Image Density Adjustment (manual only: 5 levels)
Copy Mode (Text/Photo/Mixed)
Color Balance Adjustment
Combine Copy (2-in-1, 4-in-1 via ADF only)
Duplex Copy
ID Card Copy
Memory Copy
Electronic Sorting (collation, ADF only)
Scanner Specifications
Scan Modes
Full-color, Black and White, Grayscale
Black and White: MH/MR/MMR Color/Grayscale: JPEG
Scan Resolution
Up to 1200 x 1200 dpi (optical)
Up to 19200 x 19200 dpi (interpolated)
Scan Speed
Black and White: Less than 5 seconds per-page
Grayscale: Less than 5 seconds-per-page
Full-Color: Less than 10 seconds-per page
Scan Interface
USB 2.0, 10/100Base-TX Ethernet
TWAIN Driver, Presto! PageManager
Scanner Features
TWAIN/WIA, Scan-to-Email/Folder/ FTP/USB
Facsimile Specifications
ITU-T Group 3
Standard Mode: 200 x 100 dpi
Fine Mode: 200 x 200 dpi
Scanning Speed
Less than 5 seconds-per-page (B&W)
Less than 10 seconds-per-page (Full-Color)
Modem Speed
33.6 Kbps with automatic fallback
Transmission Speed
Super G3: 2 seconds-per-page*
Based on ITU-T Test Chart #1 in Standard mode.
Memory Backup
1 hour
SAF Memory
One Touch / Speed Dial
20 locations/200 locations
Auto Redial, Auto Answer (3 – 5 rings), Auto/Manual/Substitute/Authorized Reception, Answering Machine Interface (FAX/TAD), Error Correction Mode, User Codes, Memory/Immediate Transmission, Parallel Memory Transmission, Resolution Adjustment, Image Reduction, Serial Broadcasting (100 locations), Smoothing, Contrast Control, PC Fax (Windows only)
Supplies & Accessories
Controller Options
Wireless Adaptor SX-2500CG
Part # 100118FNG
Paper Feed Unit Type TK 1010
Part #
Black All-In-One Cartridge SP C220A
2,300 pages* Part # 406046
Cyan All-In-One Cartridge SP C220A
2,300 pages* Part # 406047
Magenta All-In-One Cartridge SP C220A
2,300 pages* Part # 406048
Yellow All-In-One Cartridge SP C220A
2,300 pages* Part # 406044
Waste Toner Bottle Type 220
25,000 pages Part # 406043
* Declared yield values in accordance with ISO/IEC 19798. Actual yields may vary based on types of images printed and other factors.
This product is under warranty against defects for a period of one year from the date of purchase. Consumables are under warranty for a period of 90 days from the date of purchase or until depleted, whichever comes first. Please refer to warranty documents shipped with the product for more details.
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Browse GoColumbiaMo.com Skip top Navigation. Translate this page
The mission of the Office of Neighborhood Services is to improve the quality of life for Columbia's residents through fairly and swiftly enforcing city codes related to residential life and build a sense of community by offering valuable volunteer opportunities, providing resources for neighborhood leaders to solve issues independently and managing donations to support our community.
Community Development Block Grant (CDBG) Program: Federal program to improve low to moderate income households and neighborhoods by creating or enhancing decent housing, a suitable living environment, and econcomic development opportunities.
HOME Programs: Federal program to create affordable housing.
CDBG and HOME funded activities are guided by needs, goals, and deliverables as identified in the Consolidated Plan.


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FYI the Dolphins have neverrrr been as bad as the Cardinals are right now, I'd take cleo lemon or ray lucas before Skelton or Lindley
FYI the Dolphins have neverrrr been as bad as the Cardinals are right now, I'd take cleo lemon or ray lucas before Skelton or Lindley
Dumb thread...not even comparable.
It's too bad Fitzgerald's talents are being wasted in that offense (which is also hurting my fantasy league, btw). They may have the worst QB situation in the league in Arizona. Man....imagine if Tannehill had a Larry Fitzgerald to throw to.
Why the hell do we deserve an apology? Our stadium is never even half packed every year, at least Cards fans show up for their teams games. I mean damn, if you want your apology so bad at least show up to the ****in games.
Credit: DisturbedShifty
there'll be none put forth Ireland believes that what he's been doing for 5 seasons is right, and he's convinced the owner of it. so don't expect profound change expect more of the same.
I don't feel sorry for Larry Fitz, he basically demanded they trade for Kolb or he was leaving, and they did just that. The only problem, they needed so many other things. It's been proven that the Cardinals OL can't protect worth a crap, so now they have QB's under pressure constantly, have no time to make a decision, and this is the result. I live in AZ, and I love ragging on Cardinals fans. I just wonder how many seasons of ****ty football here it's going to take for these bandwagon fans to stop selling out home games, because that's all Arizona sports are, bandwagon fans.


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I weigh 125 pounds more than my ideal weight. I have high blood pressure and diabetes, and I'm constantly exhausted. Plus, my hips hurt when I walk. Should I be thinking about stomach stapling surgery?
Daniel D. Tran, MD, director of the Weight Management Center at Bridgeport Hospital, replies:
Simply being obese can cause all of the physical symptoms you mention. Losing most of that weight can often do away with high blood pressure, diabetes, joint pain, and other conditions, returning you to a healthier life.
Bariatric surgery, sometimes called stomach stapling, reduces the size of the stomach so it holds only a few tablespoons of food. This can be very helpful for seriously overweight people who have been unable to lose weight any other way.
The decision is up to you. Talk it over with your personal physician. And to learn more, go to our website, www.BridgeportHospital.com/WeightCenter.
If you don't have web access, call 1-888-357-2396 for a 28-page booklet about bariatric surgery.


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as far as I know, Linux has 'fast interrupts', those that were requested with SA_INTERRUPT flag; fast interrupts are executed with all other interrupts disabled on the current CPU. But how does it differ from the normal interrupt handler behavior (where)?
As of today, you can mostly forget about the
If you have a kernel before 2.6.18, you'll probably won't use it (see Justin's answer).
Today's usage of
Concerning the difference; a normal interrupt can be interrupted by an other interrupt (preemption), a "fast" one on the other hand, can not.
There is a good write up here:
So the only difference is the one that you mentioned; that fast interrupt handlers execute with all other interrupt handlers disabled, for faster performance.