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The ProTEV Protease is an improved 50kDa version of the Nla protease from Tobacco Etch Virus (TEV), which has been engineered to be more stable than native TEV protease for prolonged enzymatic stability. It is used primarily to cleave affinity tags from fusion proteins during or after affinity purification.
Jessica Anderson, Jami English and John Shultz
Many proteins are expressed as fusion partners with affinity tags, such as glutathione-S-transferase (GST) or maltose binding protein (MBP), to selectively bind the proteins using affinity purification resins. While such resins yield high-purity protein quickly, the large affinity tags are undesirable for some downstream applications. Therefore, most expression vectors are designed with a specific protein cleavage site between the two fusion partners to remove the affinity tag after purification.
A common protease used to remove affinity tags, Factor Xa (FXa; Cat.# V5581), may also cleave the fusion protein because its four-amino acid recognition sequence is quite common. In contrast, ProTEV Protease recognizes a rare amino acid sequence, EXXYXQ, where X is any amino acid and cleavage occurs after the glutamine residue(1)
. In addition, cleavage sites for TEV protease are found in many common vectors including the thepFN2A and pFN2K (GST) Flexi® Vectors ( Cat.# C8461 and C8471).
ProTEV Protease is manufactured to a high standard of purity and is free from nonspecific activity. Overdigestion of a protein panel with ProTEV Protease results in cleavage of only the control protein containing a ProTEV Protease recognition sequence (Figure 1). Since the ProTEV Protease recognition sequence is uncommon, unintentional cleavage of the protein of interest is rare.
Fifteen micrograms of six different proteins were incubated with or without 10 units of ProTEV Protease for 72 hours at 30°C. Digestion of the proteins was analyzed by SDS-PAGE and stained with SimplyBlue™ SafeStain (Invitrogen). Lane M, SeeBlue® Plus2 (Invitrogen); lane 1, ProTEV Protease alone; lanes 2,3, GST-MBP with TEV protease site; lanes 4,5, GST-HaloTag® fusion protein with FXa protease site; lanes 6,7, bovine serum albumin (BSA); lanes 8,9, phosphorylase B (Sigma); lanes 10,11, β-galactosidase (Sigma); lanes 12,13, QuantiLum® Recombinant Luciferase.
ProTEV Protease is provided with a reaction buffer at pH 7; however, the protease is active over a pH range of 5.5–8.5, allowing it to be used under the conditions most appropriate for the protein of interest. The greatest activity of ProTEV Protease occurs at 30°C, but the protease will cleave fusion proteins over a temperature range of 4–34°C. As with many enzymes, ProTEV Protease cleaves more slowly as the temperature is decreased (Table 1).
For more details on ProTEV Protease, read the full-length Promega Notes article.
Scientific Style and Format, 7th edition, 2006
Anderson, J., English, J. and Shultz, J.
ProTEV Protease for Fusion Protein Processing.
[Internet] April 2008. [cited: year, month, date]. Available from:
American Medical Association, Manual of Style, 10th edition, 2007
Anderson, J., English, J. and Shultz, J.
ProTEV Protease for Fusion Protein Processing.
Promega Corporation Web site.
Updated April 2008.
Accessed Month Day, Year.
Products may be covered by pending or issued patents or may have certain limitations on use. Please visit our patent and trademark web page for more information.
Simply Blue is a trademark and SeeBlue is a registered trademark of Invitrogen Corporation.
We offer a range of services to help you succeed using Promega technologies. From product training to set up of automated systems and development of custom applications—our scientific support goes beyond the basics.
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I finally found the solution.
It was quite bizarre - everything seemed to work as a charm: I connected the printer via UPS, found it immediately in CUPS, printed a test page, which was perfect. I then created a new printer in W7 - the system found it quickly, I installed a Postscript printer (Generic - Windows Colour Thingy), and printed a test page; the printer indicated an error.
After much searching and looking in debug logs for Samba and CUPS, I finally discovered that if I commented out the raw filter setting in CUPS, it worked - I don't remember the exact file and I am not home, but it was in /etc/cups and something with "octet-stream" and "raw".

subset: commoncrawl


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New 'Ghost Rider: Spirit of Vengeance' Trailer: More Drama, Less Fiery Pee [Video]
Following this week's release of a new poster, Sony Pictures has debuted its theatrical trailer for Ghost Rider: Spirit of Vengeance on Yahoo! Movies. Fans who caught the film's initial trailer will recognized a portion of action (and urination) footage showcasing Nicolas Cage as Johnny Blaze/Ghost R


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Kitchenware—like the recipe itself—is the kind of thing you hope to inherit from the older generations. But if you're not the favorite grandchild, there's always Truehomeware from RIESS, an over 400-year-old Austrian family firm dedicated to designs that endure. With an ash wood lid and a stackable shape, this enamel and steel storage pot provides a flavor-neutral and non-porous for preserving food. Gram would approve.
Capacity: 18 oz.
The Truehomeware collection is a collaboration between RIESS and industrial design studio dottings. Each piece is recyclable, and manufactured by RIESS in the Ybbsitz region of Austria using clean energy that comes from hydropower plants.
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People like Robert Floyd who had kidney cancer, lost sight in one eye and was having other eye problems. While his wife had insurance, once the insurance company found out about his condition they raised the rate to $4,000 a month and said the policy couldn't cover kidney or eye problems. Because of his disability he can't work and the family is now on a waiting list for a state program where they could buy coverage for about $370 a month. While he's waiting he will get worse and he could die joining the thousands of others who have lost their lives.
The human toll is coupled by the financial cost.
When insurance companies rule, they have no competition and no impetus to lower costs or create access. Their job is to make money and we are their profit center. If we get too sick, the profits they make on us go down so they create all kinds of clauses to deny sick people coverage, keep premiums high and maximize their profits. The average salary for the CEOs of the top health insurance companies is over 14.7 million dollars.
That's why we need a change. It's not acceptable for people in the wealthiest country in the world to die because they can't afford to see a doctor in time.
And now we have a chance to change it.
But it won't happen without activism and our voice. President Obama cannot do it alone. Without us actively involved, the lobbyists' money will win and health care reform will fail.
We are fighting for a strong public option in the current bills moving through Congress. It is the only measure in the bill that will assure real competition and keep health care affordable and accessible. It is a step forward in taking the profit out of the equation and allows people who cannot afford private health insurance and are not eligible to Medicaid to still have coverage.
A strong public option creates choice, competition and helps level the playing field for individuals and insurance companies. Think of the public option as the equivalent to the United States Postal Service, you are not forced to pay exorbitant costs for UPS or FedEx, because you have the option to send mail with a $.44 stamp. The public option would do the same, offer an affordable alternative.
We all stand to benefit from changes being considered by Congress. Those of you who have health insurance stand to gain in the way of lower cost, better coverage and more choices. If sweeping reform is achieved, you will no longer have to foot the bill in higher premiums and prices to make up for the unpaid expenses of others.
Many in Congress would water the public option down or eliminate it all together. We have to say no. We have to say no more Robert Floyds. No more unnecessary deaths. No more insurance company domination. That is why the NAACP has joined with the National Urban League, National Conference of Black Mayors, National Coalition for Civic Participation and the Black Leadership Forum and over 50 other civil rights groups to open up a war room in Washington DC. At our war room we are phone banking urging people to let their voice be heard, educating people on the health care reform bills and coordinating rallies with our communities around the country.
But it won't happen without you. Together we are the soldiers that have always made our country greater. Whether we were fighting for voting rights or the desegregation of our schools, or to save an innocent man on death row..The difference between winning and losing was you. Raise your voice now. You can contact your congressional representative by calling 1-866-783-2462 or visit www.NAACP.org/880.
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Here is a truism: American foreign policy has always been torn between interests and ideals. That dichotomy long predates the popular uprisings roiling Egypt and Tunisia. It animated the Cold War debates over whether we should support democratically elected socialists or Western-aligned autocrats. Policymakers usually settled those disputes by judging what would be most advantageous to the United States, but even when Washington made a noble choice, as when Americans helped push out Filipino kleptocrat Ferdinand Marcos in 1986, things mostly worked out for us in the end. The world is filled with relatively stable nations we once meddled in, still friendly enough to the United States. They do not continue, in perpetuity, to serve up diplomatic, social, economic, and military crises.
The Middle East is, and has always been, a special problem; Egypt is only the latest reminder. Successive presidents have tested both approaches there. The architects of realpolitik tried to balance powers, fabricate stability, and secure natural resources. These realists, alarmed by the unpredictability of democracy, have generally controlled American foreign policy. In the Middle East, they propped up authoritarian leaders, often tolerating economic stagnation and political repression—a story that ends in anti-Western sentiment and Islamism (a strain of which sparked the transnational jihad we are battling today).
Idealists, meanwhile, have threatened to withdraw aid from governments, barked about human rights, and tried to push democracy onto nations in the region, usually with weak follow-through. Where they've failed, they have incurred resentment and charges of imperialism. But even where these experiments were genuinely attempted, such as the 2006 Palestinian election that brought Hamas to power in Gaza, they always seem to end badly.
Egypt offered the quintessential formula: On one hand, supporting the 30-year regime of President Hosni Mubarak would have kept Egyptians disenfranchised and would probably have subjected them to further oppression, poverty, and torpor—all in direct transgression of the values that Washington constantly commends to Arab despots. At best, it would have meant merely a stay of execution for Mubarak.
Abandoning him, though, could be catastrophic. Sixty years of tradition went into America's Egypt strategy of warding off exactly the risks that the White House has now assumed by showing Mubarak the door. For one, if Mubarak's thugs and opposition leaders—insofar as there are any—won't pack up their dispute, the violence could end who knows where. Democracy would lose plenty of luster in the Middle East if the first uprising to depose a nationalist dictator did so amid bloodshed.
What's more, policymakers have no idea who can fill the vacuum. The uprising has been organic, and although the moderate former U.N. nuclear inspector Mohamed ElBaradei has rallied Mubarak's opponents today, there's no promise that they'll stick with him tomorrow, after they've accomplished their objective. If the uprising fractures, as it did after the 1979 Iranian revolution, it will be vulnerable to a takeover by the most-radical elements—a common feature of rebellions. What if Cairo produces a Sunni reflection
of Tehran?
Finally, a representative government in Egypt would offer a posture much more hostile to the West than Mubarak's unpopular program. The outgoing president hunted down terrorists, kept Islamists at bay (which, unfortunately, goaded them all the more), and made the world safe for Israel by holding to a crucial treaty. He was a model for other regional autocrats who are all now in danger—along with those policies and the entire American strategy based on them.
In the Bush years, White House officials recognized the historical failures of realpolitik and declared that liberty was worth the risks. But they halted the freedom agenda when they realized what it might actually mean. Now, idealists are finally getting democracy over stability—another stance with a history of failure. Supporting dictators doesn't work; but removing them doesn't work either. The lesson of Egypt, and of America's tortuous role in the Middle East, is that we would be best served by having to make no choice at all.
For the West, interests have almost always outweighed ideals in the Middle East. Even after World War II, when Britain and France withdrew from their colonies, the Cold War settled nearly all arguments in favor of realism. Washington was convinced that it needed every possible asset to fight the Soviets, and so alignment between East and West, much more than liberal democracy, informed American decisions about which nations to court. "We've been a much more realpolitik power than most politicians will say and most citizens believe," said Rajan Menon, a political scientist at the City College of New York and the author of The End of Alliances.
James Kitfield contributed contributed to this article.
This article appears in the February 5, 2011 edition of National Journal Magazine.


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The Community of Disc Golfers and About All Things Disc Golf
Greetings DGRUS World,
Cassidy aka "Wicked Dyes" started something interesting. He created "The DGRUS Great Disc Adventure". With this concept he asks " A club to track the Great Disc Adventure. If a disc labeled with The DGRUS Great Disc Adventure is found please take a photo and post it on here along with your name/ date/ and location found then leave it for another to find".
Also he asks
How to prepare a disc for its adventure!
On the underside of the disc put:
The DGRUS Great Disc Adventure
Take photo of you using the disc
Go to:
upload photo and leave name, date, and location
Now sign disc and leave for someone else to find and use!
Once you have sent out a disc for the first time please create a discussion with the Disc Name, Color, Stamp (distinguishing marks) as the tittle.
This is a great concept. A way to track a lost disc. But I would like to start something similiar yet different. I am taking Cassidy's idea and taking it a step further. I am stuck here in Florida. And realistically, will be for a long time. I would love to travel and experience many different places and Disc Golf Courses. But since I can not, there is nothing that says that I can't sent a disc of mine all over the place. What am I talking about ?
"The Brotherhood of the Traveling Disc"
There are fifty states in the United States. For those who do not know here is a list...............
I will need to find a friend in each state. This DGRUS Friend has to befriend me, send me their address via private mail (I will not spam it, and I'll only send it to the person needing it) and promise to do the following.......
* Upon receiving the disc, take it to their local Course.
* Take a picture of themself holding the Disc in front of their Course Sign
* Play the course using the Disc when possible
* Upon returning home, go to this discussion, post the picture, and write a little story about it at their course
* Mail the Disc to the Next person on the list.
So far, I would like the following people (Currently on my Friend's list) to participate :
Ed Horst..................... Mr Ed Florida
Cassidy......................Wicked Dyes Michigan
Mark Ellis....................Mark Ellis Michigan
Shawn West.................Dookville California
Donny Olow..................Donny Olow Morley Field California. First place I ever played
David Reisner............... Kirk Hawaii
Steve West..................Steve West Minnesota
Tim...........................Tim York New Mexico
Monte........................ Moe Dee New Jersey
Brett..................... email@example.com Wisconsin
If they all accept, all I'll need is 42 more friends. If they do not accept, I'll need someone to step up and take over representing that state.
Would you be willing to be part of the "Brotherhood" ?
I can not make this happen unless I have enough friends to cover every state.
Join the "Brotherhood of the Traveling Disc"
Views: 7348
July 3, 2102 9am
Day three was at Woodmansee Park with my son Jeff, and my grandsons Mason (10 yrs) and Tucker (6 yrs).
This course is closest to home so I play it more than any. It's a 9 hole course with 2 tee pads per hole for 18. It's wooded and brushy with a creek running through it and open fields on the last three holes. It's fairly technical and a lot of fun.
To be honest, I wasn't sure I wanted to use Dad here because I didn't want to be the guy that lost him in the brush. Three off my discs have been swallowed up out here never to be seen again. But it all worked out great and a good time was had by all.
I used Dad on holes 2, 5, and 7. Because of time issues we only played 9 holes.
On hole 2 I used Dad for a long right hand corner through some trees off the tee pad. The basket was in the long position.
My approach shot was also a right hand corner and Dad landed close enough for an easy par putt.
Unfortunately my computer ate or destroyed the rest of the pictures of this course, so I'll finish it with the description of what happened.
On hole 5 my drive went way left and short of the basket after bouncing off a tree. I needed another anheiser shot from Dad and he delivered flawlessly leaving me an easy 15 foot putt. Being over confident with the putt I fluffed it low and bounced it off the basket. Bogey!
Hole 7 seven is a drive across an open field into a stand of trees. My drive was short and left so I decided to try a heiser shot with Dad into a hole in the trees and brush, and left to the basket. I hit the hole, and after a lot of bouncing from tree to tree I was left with a 20 foot putt that I made for par.
I don't know what my score was for sure, but more imprtantly it was a lot of fun for all and we got in some quality family time.
It was a great honor to be a part of this venture and to play with Dad. I hope everyone involed has as much fun as I did. It was fantastic! Thank you.
Dad has been handed off to my son Jeff and is in Washington State for the next leg.
It's a small world. I have many, many fond memories of fishing with my dad and the rest of the family. It was nearly an every weekend event. I haven't fished in a long time either, and am longing to get back to it.
My father passed in 1997 and we put his ashes in one of his many favorite fishing spots.
Family times are good times!
I remember Fishing with Grandpa down on the Willamette River in the wooden rowboat you used to have. Right in the area where you spread his ashes, I think. :)
So, I have had a FEW Rounds with the "Dad" disc now. 2 down in Oregon with my Dad, the 2nd being with my Dad and my Kids. I got to see me Dad make some Awesome Throws with the "Dad" disc down in Oregon at our Favorite courses. This has been an AWESOME experience getting to be a part of this, let alone having it add some good Quality Family time for the Nichols Clan. :)
We are back up in Washington and had PERFECT discin' weather today, so my Boys and I headed out to NIck Loutsis Park in Carnation, Washington. It is a short, but Technical, 9 hole course with 2 Tee pads per hole for a full 18.
We started the round in good Fashion and the Boys threw "Dad" 1st! Tucker, my 6 year old, took a good Forehand pull on Hole 1.
He got a good toss on it and got it out 2/3rds of the way down the fairway. :) He took a 4 on the hole using "Dad" for every shot. He even putted with "Dad" and made another good photo opp....
I threw "Dad" on Hole 2. This is a Low Ceiling Anhyzer shot that I have trouble with.
It is only a 247ft Shot, but I usually throw a higher Anny line, so I screw it up often. I grabbed "Dad" and put him on a lower line and he pulled a B-E-A-U-tiful Flex shot for me and got me up close for a shot at a Deuce...I missed the Deuce Putt as Usual. :)
Hole 3 is the Longest hole on the Course at 409ft. Tucker used "Dad" for his drive. Tucker likes to put down a Forehand Roller on this hole to get some extra Distance, and that's Just what he did with "Dad"...
Mason then Used "Dad" for his 2nd throw on this Long Hole and got a GREAT Back hand pull using "Dad" to get within 100ft of the Basket. I was impressed with that Throw!
Mason ended up Flicking "Dad" for his upshot and then Dropping "Dad" into the Basket for a 4. That is his lowest score on this hole ever. He was Way Stoked!
Dad stayed in the Bag until hole 7 Because of the HUGE bunches of thick thorn bushes lining the fairways on 5&6. We didn't want to lose him....
I got the next throw with "Dad" on hole 7. This a a Great little Hyzer hole for me. One day I will Ace this hole. I like to put up a good, high stall Hyzer and let it fall right into the basket in tree line. You can see it dead center in this photo...
I put "Dad" on a High Hyzer and let him rip. I hit the line I wanted SO PURE I thought I had just Aced this hole, finally. Really, I am not Joking!!!! Even the Boys were jumping up and down thinking I was going to hit it. So, as "Dad" got Almost to the tree line, I got a big wind gust that air bounced "Dad" straight down.... SHORT!!!!! Lol. Left me with a bid for Deuce, anyway.....
We finished out the 1st 9 and Mason used "Dad" again on 9. He ended up pulling another 4 using "Dad" for the entire hole. Once again, his best score on that hole, ever.... :)
Mason's Tee shot on 9 with "Dad"....
We did play another 9 Holes with "Dad". Unfortunately, the lens on my point and shoot camera freeked out and would not open, or function anymore. We all used "Dad" with great success for another 9 Holes. I flexed "Dad" on a Forehand line on hole 4 and Parked it for my only Deuce of the day. The Boys made some great throws, and scores, with "Dad". :)
We actually met another guy named Matt that ended up joining us on our 2nd 9 and he thought the "Brotherhood of the Traveling Disc" was an AWESOME thing to partake in. He didn't throw "Dad", but really enjoyed the story and getting to hear about it.
The other part of it was that Matt is a 3rd grade teacher and has been trying to figure out how to get Disc Golf into his school's P.E. program, in one way or another. I got to tell him about the EDGE Program and he seemed Super Stoked and was going to check it out. All in all, it was a Great Day with "Dad" out on the course. :)
I have got to see "Dad" used for multiple rounds. "Dad" got my Father, my Kids, and I out for a few days sharing some great times for a GREAT purpose. I feel very Lucky to have been allowed to be a Part of this whole experience. :):):):)
Nice post!! Wish I was there!
Thanks Victor. :) It was a GREAT Experience! Just let me know where to send "Dad" next and I will get him on his way! :)
Ok all! I have been instructed to ship to UTAH next to JP Pulley. I will have "Dad" in the mail today, or 1st thing tomorrow. I am shipping via USPS Priority Mail, so JP should receive "Dad" by the end of the Week! :)
"Dad" left for Utah today for the next leg of his Journey. Have Fun JP. :)
Hey all just finished with dad and awaiting mailing instructions. Here is my account of my visit with Dad.
Here's a brief background on me and how I got started in disc golf: I was born in Utah in 1974 and lived here for most of my life. In 1996, I decided it was time for a change and moved to Portland,Oregon. It wasn't until probably the year 2000 before I had even heard of disc golf. My first experience with disc golf was when some friends took me to a school yard with Frisbees and made up holes. It was a great time and I had to try it on a real course. My first course I had the pleasure of playing with real discs was Milo McIver State park in Estacada, OR and I was instantly hooked. I played until I moved home at the end of 2001. At that point, I started to have some serious back problems and quite playing until about 2 years ago. Once I started again I realized how much I loved the sport and was again bitten by the disc golf bug.
After reading as much as I could and watching all the disc golf instruction videos online, I came across this site which I found to be full of friendly people and a plethora of good information. On Aug 9th 2011, I saw Daddy Dragons post about Dad and thought what an amazing idea; I immediately wanted to be a part of this journey. I patiently waited until July 12th (just shy a year after signing up) to represent Utah, Wyoming and Idaho. I am representing 3 states so I was lucky enough to have Dad a little longer than some of the others. Because of this, I was able to use him on the holes that best suited him and still get to throw him enough.
During the week leading up to Dad's arrival, we were experiencing face-melting heat in the triple digits. I was at work debating on playing a round or not and had decided 103 degrees was just way too hot and that I would just chill at home. When I got home, I was pleasantly surprised to see dad waiting for me fresh from his trip to the Pacific Northwest, where I started playing this game we love so much. I knew dad was coming but wasn't expecting him for a day or two. Being a good host, I immediately grabbed Dad and my bag, and then headed out to my local course, named "Walter Frederick Morrison Creekside." The course was established in 1982 and is one of the first 50 courses made. It is named after the inventor of the Frisbee, Walter Frederick Morrison, who happens to be from Utah.
My first throw with Dad was on hole 2. It's about a 280' RHBH anhyzer throw into a nook of trees which landed about 20 feet shy. Unfortunately, I missed the putt but still ended up with a par. The next hole Dad flew on was hole 4 which is about a 350 RHBH anhyzer. Unfortunately, dad clipped some trees and ended up about 60' out and I again ended up with a par.
Friday July 13th
The temperature had gone from blazing hot to cool and rainy. I wasn't about to let a little rain stop me from playing the best course in the state of Utah. So I finished work and immediately drove to Solitude Ski resort, jumped on the lift and began our journey. Solitudes' base is at 7,988 feet with a summit elevation of 10,035 feet.
This is the lift you take to the top of the mountain.
© 2015 Created by Terry "the Pirate" Calhoun.


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"Rhino Bib"
By Donna Honeyman
Comments: I ordered this for my son and the son he has "on the way." He loves rhino's and I was so excited to find something that could be personalized. The bib is cute and sure to be used as an heirloom. : )


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NSN: 8465-01-499-0674 (Black)
No matter what the assignment, no matter what the gear, CamelBak's redesigned MotherLode can handle it. It is reinforced webbing allows for easy integration of a jump harness, while still hauling over 2,100 cu.in. (35L) of gear and 100 oz. (3L) of water effortlessly on an Independent Suspension Harness. Store gear and communications in cargo spaces complete with internal organizers for tools and small items. Load up. Move out.
COLOR: Black
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These rugged Snowmass boots will help you to fight from those inclement weather conditions. It is constructed from waterproof nylon upper with rubber sole to provide the shoe ample strength and durability. The fixed 200b thinsulate insulation keeps your feet warm and cozy in freezing conditions and the moisture-wicking lining keep your feet dry. The fleece snow collar and gusset tongue along with waterproof rubber shell make the shoe extremely warmth providing and make you able to wear it in any weather condition on any terrain.
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In excellent 51.46 HEAD Athlete Konrad Czerniak won Bronze over 100m butterfly at the Barcelona World-Championships, he missed Silver by just 3/100 seconds.
Konrad was using in final the HEAD Liquidfire Pro Race-Suit technology and Ultimate LSR race-goggles.
He 2nd HEAD Athlete in final, Steffen Deibler was unfortunate, as 1st after the 50m turn, he ended 4th just few 1/100 of seconds behind Konrad


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15 April 2010
Posted in Dr. Ying Competition
The year is 2008 and Noel Turner was announced as the 10th annual winner of the Dr. Ying Science Challenge at the Orlando Science Center. His submission of the project entitled "Bridge Over Troubled Neurons" earned 16-year-old Noel, a hefty $5,000. Noel's research also won prizes at the Brevard County Intercoastal Science Fair.
What exactly did Noel investigate? Noel took it upon himself to figure out treatments to neural system diseases and injuries. The research focused on engineering a way to manipulate neurosystem stem cells into the body to help with diseases and injuries that damage, or even kill, existing nerve cells.
This was only one of the remarkable research entries recognized at a previous year's competition. This year is sure to bring out more amazing talent from the Central Florida community. The Dr. Nelson Ying Student Science Competition will mark its 12th year in collaboration with the Orlando Science Center on April 23, 2010.


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Saw this. Interesting.
No real surprises
BYU 1984 National Champs.
Glad to see Michonne find Ricks group. Carrol is back.
So Ricks group is now: Rick, Carl, Darryl, Carrol, Axel, Oscar, Michonne, Herscel, Maggie, Glen, daughter #2 and baby girl.
I consider Andrea one of the Governors group at this point. That may change if she finds his heads in jars and things like that but unless that happens I think she will back his play short of attacking Ricks group.
#BelieveInLindsey #BelieveInSnyder
Rick and his phone wrapped up much quicker than it did in the books.
I, HeavenHarris, hereby pledge to my fellow JFC'rs that I will no longer give out neg-reps. All it does is cause negative things, like fights, drama, bitching, ill will, bad feelings, etc.
Love, not hate, is the answer bros and moes.
LOL Lol breaks his pledge 5 days later hahahaha


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Think of the Illinois Republican presidential primary as a re-run of an old television episode. If you're a Mitt Romney supporter, it's a story you know but are eager to watch again. If you back Rick Santorum, you might want to switch off the TV.
Tuesday's contest in the Land of Lincoln is following a familiar path this primary season: The business-focused Romney is poised to win a state whose electorate is more upscale and secular, full of suburban Republicans drawn to his jobs-heavy message. And as has been the case in a litany of previous battles, Romney and his affiliated super PAC have outgunned their Santorum counterparts to give the former Massachusetts governor an edge in the state, according to recent polls.
Those factors add up to a near-universal expectation that the GOP front-runner, despite his most recent bruisings in Alabama and Mississippi, is set to win another key victory.
"Romney will win the delegate count regardless, unless something really strange happens," said Kent Redfield, a professor emeritus of politics at the University of Illinois-Springfield. "This isn't going to be a huge victory for Romney, but I think it will be comfortable."
Ohio and Michigan are the closest facsimiles to Illinois, two Midwest primaries that featured narrow Romney wins. Each state has the same rough demographic sketch, consisting of a sizable population of college-educated, secular Republicans. White-collar Republicans constituted 51 percent of the vote in Michigan, for example – four years ago, the Illinois primary featured 52 percent of college-educated voters.
In Ohio, 47 percent of voters were evangelical, according to exit polls taken after this year's primary. That's a similar share to the 41 percent in Illinois in 2008. Both states are far less religious than other GOP primary states – three-quarters of the GOP vote in Alabama, for instance, was evangelical.
Despite the demographic edge, Romney won Michigan and Ohio by three and one point, respectively -- minute victories that would seem to portend another close contest in Illinois. But the circumstances this go-round are different. The onetime Bay State governor entered the previous two battles trailing his rival, sometimes by double digits. In Illinois, he enters the race with the lead already in hand.
A Chicago Tribune/WGN-TV poll released Sunday reported Romney in the lead at 35 percent, a small edge over Santorum's 31 percent. Ex-House Speaker Newt Gingrich, at 12 percent, and Rep. Ron Paul, 7 percent, each trailed far behind. And that was before Romney's TV campaign began to pound away at Santorum.
Santorum himself on Friday acknowledged he's an underdog.
"I don't think there was a single poll that had us up in Mississippi, so I don't really worry too much about polls," he told reporters after a speech in Osage Beach, Mo. "Look, Illinois's a tough state, I understand. When you're getting outspent 10 to 1, it's hard. But we're gonna keep working, and do the best we can. And we're fighting money, we're fighting the organization, and we're fighting a divided conservative vote. That's a pretty hard hill, but we've been climbing it and doing well."
As the former senator referenced, he's being outspent heavily in Illinois, by some estimates as much as five-to-one. That includes a new hard-hitting released Friday that attacks Santorum as an "economic lightweight" and questions his ability to beat President Obama in the fall.
If Santorum has hope, it lies with Illinois's more rural, conservative voters in the state's southern half. They're the voters who helped conservative state senator Bill Brady win the party's GOP nomination for governor in 2010 over Chicago-area lawmaker Kirk Dillard -- though Brady could not overtake Democrat Pat Quinn in the general election.
"Romney will do better much better in the Chicago suburbs than Santorum, and Santorum will do better than Romney downstate," Redfield said.
That regional success can help Santorum win a portion of the state's 54 delegates up for grabs on Tuesday, who are allocated based on support in congressional districts. As the ex-U.S. senator hinges his strategy on denying Romney the 1,144 delegates necessary for the nomination, those small successes could be critical.
Just don't count on his rewriting the GOP primary's script.
Lindsey Boerma contributed. contributed to this article.


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Streaming Audio: {play}images/stories/videos/ErgunCaner.mp3{/play}
This week in chapel, TMC students and faculty were privileged to have the Truett-McConnell College Music Department present a Christmas concert at the First Baptist Church of Cleveland.
The featured ensembles were the Chorale, Enthroned Praise, Jazz Ensemble, and the Percussion Ensemble. Each of these groups did a phenomenal job and their efforts showed off! Thank you to all of those who participated in this special chapel service which reminded all in attendance about the fun we can have during Christmas time and most importantly, that the true reason for Christmas is Jesus Christ.
Streaming Audio: {play}images/stories/videos/ErgunCaner.mp3{/play}
Truett-McConnell College was privileged to host Dr. Ergun Caner in chapel this morning. Dr. Caner spoke a message filled with encouragement, hope, a bit of humor, and of course, a handful of love. His message was from Galatians 6:9-18. Galatians was written in the middle of Paul's ministry. This is a very important aspect in the understanding of the book: the half way point is always the toughest. Paul writes and tells us how to survive when we are right in the middle. The following are Dr. Caner's 3 points of survival:
Our scars tell our story – and God wants to use our story!
"From now on let no one cause trouble for me, for I bear on my body the brand-marks of Jesus." Galatians 6:17
Streaming Audio: {play}images/stories/videos/rickstanleyaudio.mp3{/play}Truett-McConnell students and faculty were privileged to hear from Rick Stanley in chapel this morning. Stanley has a very unique testimony and an impressive background which provides avenues for him to share the gospel with a very wide range of people; he was the step-brother and assistant to Elvis Presley.
He shared about his difficult childhood which ultimately led to the blessing of salvation for him and his family, as well as a fervent spirit in sharing the gospel. Mr. Stanley reminded attendees of how everyone has issues; but the way to fix those issues is to surround yourself with godly people and to let the reality of the cross transform your life. TMC thanks Mr. Rick Stanley for encouraging and inspiring us to focus our eyes on the cross and on the winning of people to Jesus Christ.Ezekiel 36:26-27, "Moreover, I will give you a new heart and put a new spirit within you; and I will remove the heart of stone from your flesh and give you a heart of flesh. I will put My Spirit within you and cause you to walk in My statutes, and you will be careful to observe My ordinances."
Streaming Audio: {play}images/stories/videos/lexlugeraudio.mp3{/play}Former professional wrestler, Lex Luger, spoke at Truett-McConnell Chapel on November 4, 2010.
Luger gave a testimony about his life and how God has brought him to where he is now. He began with the story of his temporary paralysis. He states two years ago, he felt a sharp pain between his shoulders which led to his paralysis from the neck down. During this time when he couldn't move any part of his body, Luger says God gave him complete peace.
"God showed me that there is strength through weakness" He states.
Luger declares that he was always chasing after status. It was an empty chase that left him feeling hollow and bare.
In May 2003, his girlfriend at the time died beside him while watching television due to a drug overdose. As a result, police came to search his house and they found numerous drugs.
Luger was thrown in jail for five years and given countless hours of community service. As a result, he began to drink more alcohol and take more drugs. As he was sitting one night on a couch in his hotel, Luger says he saw himself floating at the bottom of a pond. There was neither light nor sound and at that point, he states that he had given up hope. He then says he saw a speck of light at the bottom of the pond.
"God was saying 'sit up!'"
He tried to fix his life by immediately quitting drugs and alcohol and trying to restart his wrestling career. However, while on his way to Canada, he was arrested again and given more months in jail.
While in jail, Luger says he met a chaplain and after a couple of months, the two became friends and Luger became the chaplain's trainer. During this period Luger would ask questions about God because he had a spiritual curiosity.
Then, in April 2006, in that same hotel, Luger asked the chaplain about salvation. The chaplain was eager to explain salvation and on the same couch that he had once dreamed he was sinking, Luger gave his life to Christ.
Luger encouraged students, faculty, and staff to not live life for themselves but rather for Christ.
"Let God fulfill his purpose in you and not what you think your purpose is" He says.Truett-McConnell thanks Lex Luger for visiting the college and encouraging us to live with our minds on eternity rather than temporary earthly things.
We are Truett: Charissa Veal
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Fairfax County Fire and Rescue Department investigators have charged 15 Herndon and Chantilly juveniles with the manufacture and use of fire bombs.
According to fire investigators, all 15 youths were arrested Feb. 5 and charged with the manufacture, possession and use of fire bombs or explosive materials or devices.
Police say the charges stem from an incident about 9:15 p.m. Dec. 14, 2012, on a neighborhood playground in the 3200 block of Kinross Circle in Herndon.
The Fairfax County Police Department, including the bomb squad responded to the incident.
Police said they rendered one of the unexploded devices, a plastic two-liter bottle filled with a chemical liquid, safe at the scene.
Police said the explosive devices caused no injuries or property damage.
On Jan. 29 in Reston, a 31-year-old woman reported to police she was attacked about 7 p.m. while walking along the Washington & Old Dominion trail.
Police said the woman was on the trail near the overpass for Herndon Parkway — not far from the Town of Herndon Police department — when she noticed a man following her. She continued walking to Sunset Hills Road, where the woman said she was then dragged off of the path into a wooded area by the man.
Police said she struggled with her attacker, and he eventually fled north onto a gravel horse trail. The woman did not require medical attention, they reported.
Police have withheld some facts about the suspect but describe him as heavy set, about 25 years old, clean shaven and with short, black hair. They said the woman was unsure of his height and ethnicity but that he was wearing glasses, a dark jacket and dark jeans.
Police are investigating a strong-arm robbery that occurred in the Mount Vernon area Feb. 4. Police said shortly after 7:30 a.m., a 23-year-old woman was walking through Mount Eagle Park, between Richmond Highway and Huntington Avenue when she was allegedly assaulted by a man.
Police said the man struck the woman and took cash and property from her.
He then fled on foot, according to police. The woman was transported to a local hospital with non life-threatening injuries.
Police described the man as black, in his mid-20s, 5 feet 10 inches to 6 feet 2 inches tall, weighing between 190 and 210 pounds and wearing a black hoodie.
Anyone with information is asked to contact Fairfax County Police at 703-691-2131.
Khalil Kenyon Blackman, 31, of District Heights, Md. was convicted Feb. 5 of conspiring to commit three armed robberies of truck drivers who were delivering Apple products to area stores, including one in Fairfax.
Blackman was convicted of conspiracy to commit robbery, which carries a maximum penalty of 20 years, and brandishing a firearm, which carries a mandatory minimum of seven years and a maximum penalty of life imprisonment. Sentencing is scheduled for April 26, 2013.
According to court records and evidence at trial, Blackman and others conspired to carry out three armed robberies of delivery truck drivers hauling Apple electronics products.
Records state Feb. 11, 2011, Blackman and his co-conspirators robbed a delivery truck driver in Prince George's County, Md. Thereafter, Blackman took the majority of the products and sold them to another person and then distributed the proceeds among his conspirators.
Blackman also conspired with others to carry out two other robberies — June 15, 2011, in Fairfax, and October 30, 2011, in Prince George's County — and sold the stolen products from these robberies to others for the benefit of the conspirators. Police said the total loss to Apple was more than $130,000.
The investigation was conducted by FBI's Washington Field Office and the Fairfax County Police Department.
Fairfax County firefighters responded to a house fire about 2:15 p.m. Feb. 1 in the Pohick area of Fairfax County, where they later said an electrical panel was responsible for a house that burned to the ground.
The single family home was in the 8200 block of Morning Dew Court.
Firefighters said they encountered heavy smoke and fire coming from the bottom level and through the roof of the two-story split level home upon their arrival.
Firefighters encountered strong and gusty winds while conducting an aggressive fire attack. A second alarm was called due to the heavy wind conditions and the rapid spreading of fire, bringing more than 60 firefighters to the emergency scene. Fire officials said all occupants escaped the home unharmed. Two adults and two children have been displaced. A contractor working in the home sustained non-life threatening injuries and was transported to the Washington Hospital Burn Center. Firefighters rescued six dogs but said a seventh dog perished in the fire.
The home was complete loss. An adjacent home received minor fire damage to the siding.


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Salt Lake City, Utah perfectionist
- +
- You won't find anything like this at Petco or Petsmart. I paid as much $ for different collars at he retail pet chain and they weren't near the quality. This collar will never wear out and the leather is a high quality leather that will get better with age.
- −
- My Dogs neck measured between 15 and 16" so there isn't as much left at the end to tuck under the brass holder as I would have liked.
Published on: January 29 2014


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|Sylmar, Calif.
|High School:
|Last Team:
As a sophomore: Played in 53 games for Quinnipiac, starting in 51 of those games…Posted a .281 batting average, while contributing 48 hits, 21 runs and 19 RBI…Led the Bobcats with 11 doubles on the year…Also hit three home runs and one triple…Ranked third on the team in total bases with 70…Went 4-for-5 in stolen bases…Held a .315 on-base percentage and ranked second on the team in slugging percentages (.409).
As a freshman: Appeared and started in 48 games for the Bobcats...Led Quinnipiac with a .315 batting average and a .411 slugging percentage...Ranked first on the team with 46 hits...Was fourth on the team with 17 RBI's...Contributed 16 runs, six doubles, two homeruns and a triple...Collected eight stolen bases on the year...Was named Akadema/NEC Player of the Week and Akadema/NEC Rookie of the Week, for the week of May 10, 2010, after going 5-for-7 with six RBI's in a doubleheader against Fairleigh Dickinson. She also hit her second home run of the season against FDU.
Before Quinnipiac: Played all four years at Sylmar High School...Also played for the U-18 Firecrackers Gold...Named MVP of her high school team in her senior season.
Personal: Native of Sylmar, Calif...Daughter of Maria Teresa Rubio and Cipriano Alba...Has two sisters, Annais and Antonia...Majoring in Criminal Justice.


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IMLS Press Contacts
Jeannine Mjoseth, firstname.lastname@example.com
Mamie Bittner, email@example.com
Washington, DC—The Institute of Museum and Library Services (IMLS) today awarded $1,485,000 to 14 organizations committed to preserving and sharing the history of African American life from the period of slavery to the present day as part of the Museum Grants for African American History and Culture (AAHC) program.
"With these grants, museums dedicated to the African American experience will be able to preserve their collections, train their staff, and reach out to their communities," said Acting Director Marsha L. Semmel. "IMLS is proud to support these institutions as they work to protect our shared American history."
Over the past four years, AAHC grants have helped African American museums and Historically Black Colleges and Universities (HBCUs) build capacity by supporting professional training, technical assistance, internships, and expert consultations. The grant program is authorized by the National Museum of African American History and Culture Act and developed in consultation with the Council and Director of the Smithsonian's National Museum of African American History and Culture.
This year, awardees have proposed significant projects that will strengthen the African American museum field, including the following:
For more information about this year's grantees, please click here.
The next deadline for the Museum Grants for African American History and Culture program is January 18, 2011. Click here for more information.
About the Institute of Museum and Library Services
The Institute of Museum and Library Services is the primary source of federal support for the nation's 123,000 libraries and 17,500 museums. The Institute's mission is to create strong libraries and museums that connect people to information and ideas. The Institute works at the national level and in coordination with state and local organizations to sustain heritage, culture, and knowledge; enhance learning and innovation; and support professional development. To learn more about the Institute, please visit www.imls.gov.


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Try! Potty Trainer & Step Stool - Pink
The Try! Potty Trainer & Step Stool is there through each stage of potty training as your child becomes ready. After finishing with training potty mode, the trainer seat easily removes to help make the transition to an adult toilet easier for your child. It can also be used as a handy step stool, making sure its usefulness continues well after your little one has mastered potty training.
3 Modes of Use:
- Training Potty
- Trainer Seat
- Step Stool
Step Stool Option: Yes


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Alicia Keys
MusiCares Tribute To Carole King Spans Generations, Genres
Steven Tyler, P!nk, Lady Gaga, Sara Bareilles, Zac Brown, Miranda Lambert, Miguel and Alicia Keys were among the many artists who paid tribute last night to one of the greatest songwriters of popular music.
Alicia Keys And Maroon 5 Drum Up GRAMMY Collabo
In the spirit of GRAMMY collaborations, Maroon 5 hit the stage with Alicia Keys, who stepped out from behind the piano to beat her own drum. Maroon 5 began their performance with "Daylight," with frontman […]
Alicia Keys, Maroon 5 And Frank Ocean Added As GRAMMY Performers
For music's biggest night, Alicia Keys and Maroon 5 are joining forces to set the stage ablaze with their Jagger-like moves. The two acts announced they are performing at this year's GRAMMYs on February 10 and […]
Alicia Keys Reflects On Her First GRAMMY Win
"I didn't know where I was or what I was doing there and literally it felt like I had suddenly been beamed into the TV. It was the most out-of-body experience I'd ever had."


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Comic 11
Link: Comic 11
Translations: http://www.beaverandsteve.com/wiki/images/8/8f/Finnishflag.png Finnish, http://www.beaverandsteve.com/wiki/images/5/52/Frenchflag.png French, http://www.beaverandsteve.com/wiki/images/5/57/Polishflag.png Polish, http://www.beaverandsteve.com/wiki/images/0/04/Danishflag.png Danish, http://www.beaverandsteve.com/wiki/images/7/79/Italianflag.gif Italian
Title: the shoe goblin
Date: October 4, 2004
Summary: Steve hides from the Shoe Goblin.
Cast: Beaver, Steve, Shoe Goblin
Onomatopoeias used: "FLIP!", "CLUNK.", "JING", "WHIMPER", "WHACK!", "SOCK!", "SHOE!"
"Fin" style: Sole of a shoe.
Number of panels: 7
Panel 1
Beaver: "I wonder where Steve is today."
Panel 2
Beaver: "What are you doing in there Steve?"
Steve: "I'm hiding from the Shoe Goblin."
Panel 3
Panel 4
Panel 5
Shoe Goblin: "Have ye seen a wee dinosaur around here?"
Beaver: "Yeah - he's in here"
Panel 6
Shoe Goblin: "Thought ye could hide from me did ye?"
Panel 7
Shoe Goblin: "Prepare to receive a shoeing of EPIC PROPORTIONS!"
Steve: "No! Not the heel!"
Beaver: "It's so cute when Steve plays with his imaginary friends."
Fun Facts
Beaver is drinking tree tea
|Previous comic:
|Next comic:


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Last blast - take an extra 70% off! Click for terms & conditions.
Terms & Conditions.
Some product exclusions may apply. See product page details for more information. Clearance items are final sale. Price matching does not apply to this or any promotion. Offer is valid until September 13 at 11:59 PM PST. May not be combined with any other offer/discount (unless specified), including invitation credits, promotional gift cards and/or special discount links. Discount applied upon checkout. Log in to your account to see your savings.
Pattern maven Orla Kiely has perfected the art of easy-going, exuberant prints. The kind that don't just catch your eye, but turn up the corners of your mouth as well. The Wallflower Duvet Set features the Irish designer's instantly recognizable touch: a combination of bold repetitious abstractions with a nostalgic nod to mid-century mod color palettes. The luxe bedding is woven from 200-thread-count pure Egyptian cotton.
Includes 1 twin duvet cover and 1 standard sham.
Wash pillowcase and duvet cover together to maintain color using non-optically bright detergent; tumble dry low. Hot iron while damp or with steam.
This product has no reviews yet. Be the first to review this product. Write a review
Enjoy 10% off your first order*


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|St. George
202 Snow Canyon Rd
Ivins, UT 84738
|P.O. Box 2149
St. George,
|Toll Free:
|Red Mountain Resort Guides
Red Mountain Resort Guides
Backpacking/Hiking Guides
St. George
Your Red Mountain Spa adventure is enhanced by the opportunity to explore the Great American Southwest in the Grand Circle of National Parks. Our day hikes/trips to the dramatic natural art in Zion National Park, Bryce Canyon National Park and Cedar Breaks National Monument are not to be missed. Our unique location allows us to provide a wide range of extended day trips to the most colorful geologic wonders of the world. Join us for an unforgettable adventure. A minimum number of participants are required for all trips. Otherwise, a Guide for Hire can be arranged.
Red Mountain Spa offers a variety of customized outdoor trips led by our experienced and knowledgeable guides. Whether improving your skills in biking or navigation, or visiting a special place for rejuvenation, or exploring the Grand Circle of National Parks, Red Mountain can provide you with a world class experience.
Choose from one of our private trip sessions for a personalized experience. The Concierge at Guest Services can assist you in scheduling your outdoor adventure.
All Services and Locations
Backpacking/Hiking Guides
- Bryce Canyon Area (Description)
- Kanab - Grand Canyon No. Rim (Description)
- St. George (Description)
- Zion National Park Area (Description)
Bike Tour Guides
- St. George
Canyoneering/Rock Climbing/Rappelling
- St. George
Guest Ranches
- St. George
Horseback/Trail Riding Guides
- St. George
Kayak & Canoe Tours/Rentals
- St. George


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How can you live purposefully day to day? In his essay "A Year of Living Purposefully," Richard Leider suggests two core practices: contemplation and activation.
Contemplation is seeking answers to questions about who you are, how you should live, and where you belong. Reflective practices such as journaling, meditation [5], and guided imagery [6] enable you to relax the mind and focus on the present moment, letting go of preconceived notions of who you think you are and instead becoming open and curious about what will arise. Here are some contemplative practices that you can try:
Activation is living your truth. By acting upon what you realize about yourself, you are consciously creating an authentic life for yourself. Think of this process as gently syncing your outer life to match your inner life. When you learn to align your everyday life with moments that fulfill you and utilize your gifts, you are better able to create an authentic, purposeful life —and the more benefits you will see.
[1] http://www.takingcharge.csh.umn.edu/sites/default/files/images/thumbnails/iStock_000009454304XSmall.jpg
[2] http://www.takingcharge.csh.umn.edu/enhance-your-wellbeing/health/thoughts-emotions/how-do-thoughts-emotions-impact-health
[3] http://www.takingcharge.csh.umn.edu/explore-healing-practices/meditation
[4] http://www.takingcharge.csh.umn.edu/enhance-your-wellbeing/relationships/nurture-your-relationships
[5] http://www.takingcharge.csh.umn.edu/glossary/3#term24
[6] http://www.takingcharge.csh.umn.edu/glossary/3#term21
[7] http://richardleiderblog.info/
[8] http://www.takingcharge.csh.umn.edu/our-experts/barb-leonard-phd-rn-pnp
[9] http://www.takingcharge.csh.umn.edu/our-experts/mary-jo-kreitzer-rn-phd
[10] http://www.takingcharge.csh.umn.edu/our-experts/leeann-melin
[11] http://www.takingcharge.csh.umn.edu/activities/reflective-exercise
[12] http://www.takingcharge.csh.umn.edu/activities/keeping-dream-journal


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About MCR American Pharmaceuticals
MCR American Pharmaceuticals is a specialty pharmaceutical company focused on the marketing and development along with sales and distribution of the highest quality pharmaceuticals.
Practitioners have long trusted our products to meet the needs of their patients. We are committed to upholding our high standards. We are determined to provide you with the most convenient methods of acquiring the highest quality pharmaceuticals to meet your specific needs.
MCR American Pharmaceuticals was founded by Jack Reagin in 1991 in Birmingham, Alabama. MCR American Pharmaceuticals quickly expanded to several states in the Southeast. In 1999 MCR American Pharmaceuticals was purchased by Dave Ambrose and was relocated to Brooksville, Florida. In 2008, MCR American Pharmaceuticals was acquired by Neuro-HiTech. The company's products are now marketed throughout the United States and sold directly to the general public as well as medical offices, wholesalers, distributors and your local pharmacy.
MCR American is dedicated to providing individuals with self medication products for in home treatment and prevention of medical conditions and ailments. We offer the following products:
Contact Us
Mailing address:
MCR American Pharmaceuticals
16255 Aviation Loop
Brooksville, FL 34604
Phone number:
Our business hours are Monday-Friday 8-5 (Eastern), excluding major holidays.
Fax: 352-754-8507
About Mark Geringer
Mark Geringer, a native New York resident, is a results driven accounting professional who is highly skilled at recording, classifying, and summarizing in a significant manner and in terms of money, transactions and events. Mark Geringer graduated with a bachelor's degree in accounting from Brooklyn College. In addition to accounting, Mark Geringer has been writing music songs for leading recording companies and popular artists since 2002. Ten of his songs have ranked in the top-10 music charts around the nation.
Mark Geringer graduated from Brooklyn College with a bachelor's degree in accounting in 1979. Following his graduation, Mark passed his Uniform Certified Public Accountant Examination (Uniform CPA Exam). Since then, he has primarily worked as an independent accountant serving private individuals and small businesses.
In addition to working as a full time accountant, Mark Geringer also writes songs for leading music labels, such as RCA Records and various labels associated with the Atlantic Records Group in the United States and Warner Music International outside of the United States. Mark Geringer has also collaborated with many popular artists, such as Kelly Clarkson and Hoobastank.
Currently Mark Geringer is working on branching into the music production business. Mark Geringer has written and co-written over 10 songs that have ranked high in the top-10 music charts nationwide.
Mark Geringer attended Brooklyn College where he graduated with a bachelor's degree in accounting.
About Ron Buff
Ron Buff is the owner of Buff Sales, a marketing consulting firm based in Northville, Michigan founded in 1979. Ron Buff assists his customers in preparing, selling and merchandising their products. Furthermore, he represents large multi-national corporations and start-up inventors in various product lines such as electronics, appliances, home furnishings pet supplies, HBA and many more.
Company Background
Today, Buff Sales has grown to sell to the nation's leading retail stores, including K-Mart, Sam's Club, Wal-Mart, CVS and many others. Buff Sales represents products from around the world and sells these items to the largest retail accounts in the United States.
Buff Sales offers manufacturers the ability to market their products with a fixed percentage of sales. Buff Sales will assist you in preparing, selling and merchandising your products.
Buff Sales leads in global warming awareness, working closely with factories and customers to promote sustainability and business practices.
Some of the companies Buff Sales works with include: Bed, Bath & Beyond, Wal-Mart, Kmart, Sam's Club, Sears, Walgreens, Meijer, CVS Drugs.
The industries Buff Sales sells to include: Housewares, Consumer Electronics, Toys, Furniture, Fine Art, Hardware, Pet Products, and more.
Contact Ron Buff
Mailing Address:
143 Cady Centre
Suite 104
Northville, Michigan 48167
About Instant Checkmate
Instant Checkmate is considered a leading online background check provider that was established in 2009 and is available for individuals on a subscription basis. We supply results from billions of local criminal records, federal state records, public records, private databases and sex offender registries. Our services include delivering birth records, criminal arrest records, criminal records, sex offender offenses, marriage records, divorce records, death records, lawsuits, mugshots and more.
Background checks are a great way to discover pertinent information about your co-workers and neighbors. You can use our services to look up information about an individual's criminal, and past background history, and then use that information to make an informed decision about the individual's trustworthiness and character.
Our mission is to provide individuals with the most complete, satisfactory, and in-depth background check reports about anyone they decide. We created Instant Checkmate so everyday citizens can find out more concrete, important information about those surrounding them.
Company Goal
At Instant Checkmate, our customers come first. Our goal is to provide you with the most useful, detailed and important information on just about anyone. We're continually listening to your feedback and working tirelessly each day to improve our data, technology, website and services in general.
Our Services Include
Instant Checkmate is looking to fill the following positions:
Charitable Contributions
Instant Checkmate is a proud supporter of Break the Cycle — empowering women to break the cycle of violent dating and other domestic violence.
Company Information
Instant Checkmate is based in Las Vegas, Nevada as well as in San Diego, California. To contact us call our customer service team at 1-866-490-5980 and select option 5.
Regular Hours:
5am – 7pm Pacific Standard Time (Monday – Friday)
5am – 6pm Pacific Standard Time (Saturday and Sunday)
Holiday Hours:
6am – 2pm Pacific Standard Time
Contact Us
Mailing Address:
Instant Checkmate LLC
3995 W. Quail Ave, Ste. B
Las Vegas, NV 89118
About Kacey Montoya
Kacey Montoya was born in Orange County, California but moved to Dallas, TX when she was eight years. She later returned to California to attend California State University at Northridge. She currently works as an anchor and reporter for KOIN Local 6 in Portland, Oregon.
Past Background
Volunteer Work
About Gordon Luedtke
Gordon Luedtke, a Chicago resident, is a results driven sales professional who is highly skilled at increasing revenue for organizations. Gordon Luedtke possesses extensive sales experience in the appliance and electronics industry. Gordon Luedtke is adept at formulating strategic plans and targeted selling concepts in overall product assortment, merchandising, inventory management and profitable pricing.
Past Background
Gordon Luedtke graduated from Northern Illinois University with a bachelor's degree in finance.
About Naftali Feig
A native Israeli resident, Naftali Feig attended undergraduate and graduate school in the United States. Naftali graduated from Touro College with a Bachelor of Science in finance, recently he graduated from Cleveland State University with a Masters of Business Administration. Naftali Feig is a results driven business professional who is highly skilled at increasing revenue for organizations.
Naftali Feig's vast experience in multiple positions and industries has sharpened his creative thinking and problem solving skills. He is resourceful in handling multiple management challenges. In addition, he is a team player, personable and reliable, with strong communication skills.
Naftali is married with three children.
Contact Naftali Feig
Mailing address:
Naftali Feig
Havered 13
Maalot, Israel 21521
Phone: 04-858-1491 / 054-744-9356
About Morgan Shaw-Fox
Morgan Shaw-Fox is an actor, producer and entrepreneur. Shaw-Fox graduated from Lewis & Clark College with a bachelor's degree in theater. He currently studies improv at the UCB Theater in Los Angeles. In addition, recently Morgan Shaw-Fox and four other Los Angeles-based filmmakers launched Watchword Film Collective, an attempt at producing cutting-edge media that is created with a fresh perspective and original content on a budget.
Acting Experience
Education and Training
About Jeff Sodikoff
Chicago native resident Jeff Sodikoff emerged into the music and entertainment business in 1990 after graduating from Syracuse University with a Bachelor's degree in marketing. Following his graduation Jeff Sodikoff served as a key quarterback with the overall marketing strategy, nationwide promotion and artist development for PolyGram Group Distribution, Mercury Records, Columbia Records, Arista Records, and Sony Music Entertainment. Today he is viewed as a leading marketing executive who is a true expert when it comes to marketing and advertising.
Past Background
Honors and Awards
Jeff Sodikoff graduated from Syracuse University with a bachelor's degree in marketing and communications.
Community Activism
About Joe Pasternack
A native of New Orleans, Joe Pasternack is the assistant coach for the University of Arizona men's basketball program. Joe Pasternack has 13 years of coaching and administrative experience. Joe Pasternack is married to his wife, Lindsay, and together they have two children.
Coaching Background
Joe Pasternack joined the University of Arizona men's basketball team on May 19, 2011. He joined the team after leaving his former position as head coach at the University of New Orleans.
While working at the University of New Orleans, for four years Joe Pasternack stabilized the university's basketball program.
During his first year, Joe Pasternack held a 19-12 record and helped the program defeat a nationally-ranked team (then-No. 21 North Carolina State) for the first time since 1993. In addition, Pasternack helped the University of New Orleans defeat Big 12 Power Colorado. Joe Pasternack and the University of New Orleans men's basketball ended up winning more games pre-conference than they had in school history.
Prior to coaching at the University of New Orleans, Joe Pasternack spent eight seasons as an administrator and coach at the University of California. He oversaw the men's basketball program's scouting and game preparation efforts by studying game film, writing scouting reports, and helping prepare the team on the court as well as off for upcoming opponents.
Joe Pasternack graduated from Indiana University with a degree in marketing. While a student at IU, Pasternack was a student manager for the men's basketball team for four years under coach Bob Knight. Part of his tasks included breaking down film and assisting in scouting opponents.
Joe Pasternack on Wikipedia


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If want to ensure the integrity of a backup, would it be a necessity to use a checksum on all of my backups and not just the 'verify backup' option?
Take the 2-minute tour ×
Database Administrators Stack Exchange is a question and answer site for database professionals who wish to improve their database skills and learn from others in the community. It's 100% free, no registration required.
From MSDN
All the verify backup option does is confirm that the header of your backup is readable, nothing else.
Neither of these options will tell you that you have a good backup! The only way to confirm that your backup is good is to restore it on another system


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- Let's talk about Social Security (Forum)
- Movies for Grownups discussions (Forum)
- Put your best self forward (Group)
Golden Globes 2013 — A Good Night for Grownups
Jodie Foster and Daniel Day-Lewis won big and looked great. Plus: Sally Field, George Clooney, Julianne Moore (and more)
The Hosts
It was girls night at the Golden Globes. Tina Fey, 42, and Amy Poehler, 41, were the first-ever female hosting duo and HBO's Girls won best TV comedy. Creator/star Lena Dunham, 26, thanked her inspiring fellow nominees (including the hosts) for getting her through middle school. Ouch.
Jordan Strauss/Invision/AP
The Night's Honoree
Jodie Foster, recipient of the Golden Globe's lifetime achievement Cecil B. DeMille Award, came out, proudly shouted about being 50 (she began acting at age 3), gushed about her two sons and paid special tribute to "my amazing mother, Evelyn."
Jordan Strauss/Invision/AP
Daniel Day-Lewis
Hollywood's latest Lincoln — Daniel Day-Lewis, 55, winner for best actor in a movie drama — wasn't the only presidential figure on the stage at the Globes. Bill Clinton introduced Lincoln, a best picture nominee, which was also screened at the White House for Barack Obama.
Paul Drinkwater/NBCUniversal/Getty Images
'Zero Dark Thirty' Wins One
Director Kathryn Bigelow, 61, nominated for Zero Dark Thirty, hardly looks more than 30, or for that matter, much older than the film's nominated screenwriter, journalist Mark Boal, 40. The film's star, Jessica Chastain, 35, took home a Globe for best actress in a drama.
Jordan Strauss/Invision/AP
Quentin Tarantino
Holding his screenwriting Globe for Django Unchained, Quentin Tarantino, who turns 50 in March, adds another award to his trophy case, which already includes a Golden Globe (Inglourious Basterds) and an Oscar (Pulp Fiction), among others.
Jordan Strauss/Invision/AP
Helen Mirren
A best actress nominee for Hitchcock, Helen Mirren, 67, rocked a form-fitting Badgley-Mischka. Accompanied on the red carpet by her director husband Taylor Hackford, 68 (in dark shades), the leading lady admitted to worrying that "Tina [Fey] will poke fun at me."
Jordan Strauss/Invision/AP
Damian Lewis
Homeland's Damian Lewis, 41, kisses his prize for best actor in a TV drama, earned by playing a U.S. Marine freed after years of captivity in Afghanistan. His fellow Brit, Dame Maggie Smith, 78, won for best supporting actress in a TV series (Downton Abbey) but did not attend the festivities.
Jordan Strauss/Invision/AP
Denzel Washington
Father of four and a best actor nominee for the film Flight, Denzel Washington, 58, was flying high with his youngest daughter, Olivia, 21, on his arm. She tattled, "He's the biggest nerd you'll ever meet."
Jordan Strauss/Invision/AP
Glenn Close
Best actress nominee Glenn Close, 65, didn't win anything for Damages. The movie-turned-TV-star did, however, prove ready for her closeup when hosts Fey and Poehler, at the podium with drinks in hand to console their own losses, called out a drunken (or just acting drunk) Close.
John Shearer/Invision/AP
Jon Hamm
If Don Draper were at the 2013 Golden Globes, he'd be more than 85 years old. The Mad Men ad man was present in spirit through nominee and past winner Jon Hamm, 41, accompanied by his off-screen love, actress Jennifer Westfeldt, 42.
Chris Pizzello/Invision/AP
Kevin Costner
Kevin Costner, 57, with wife Christine Baumgartner, 38, said he was moved by the smart writing of the Hatfields & McCoys, for which he won best actor in a miniseries. Next up: playing Superman's dad in the movie Man of Steel.
Jordan Strauss/Invision/AP
Jessica Lange
Jessica Lange, 63, star of the FX drama American Horror Story: Asylum, was nominated for best actress in a miniseries. She went home empty-handed this year but won for the same role in 2012.
Todd Williamson/Invision/AP
The Cast of 'Les Miserables'
There were no 50+ stars in Les Mis, but Russell Crowe, 48, and Hugh Jackman, 44 (best actor in a musical) did have to age beyond their years. Anne Hathaway won for best supporting actress. Helena Bonham Carter, Sasha Baron Cohen, Amanda Seyfried and Eddie Redmayne joined the fun.
Jordan Strauss/Invision/AP
Julia Louis-Dreyfus
Julia Louis-Dreyfus, hilarious as the U.S. vice president in Veep, looked fabulous, but she lost — on her 52nd birthday no less — to "it girl" Lena Dunham (of HBO's Girls), a talented competitor exactly half her age.
John Shearer/Invision/AP
A Trio From 'Argo'
Ben Affleck, 40, the winning director of best picture Argo, with two of the film's producers, Grant Heslov, 47, and George Clooney, 51, whom he forgot to thank during his acceptance speech. (Affleck had his wife, Jennifer Garner, rectify the mistake when she took the stage as a presenter.)
Jordan Strauss/Invision/AP
Julianne Moore
Julianne Moore, 52, admitted to "tremendous trepidation" about playing Republican vice presidential candidate Sarah Palin in HBO's adaptation of Game Change, the best seller about the 2008 presidential race. Having conquered her fear, she won best actress in a TV movie.
Jordan Strauss/Invision/AP
Richard Gere
Nominated for playing a hedge-fund billionaire in Arbitrage, Richard Gere, 63, walked the red carpet with wife Carey Lowell, 51 (wearing red Valentino). Gere was unreachable in India when the nominations were announced. He described himself as being "very zen" about the Globes.
Jordan Strauss/Invision/AP
Christoph Waltz
Versatile, multilingual German-Austrian actor Christoph Waltz, 56, earned a big payoff (best supporting actor in a movie comedy) as bounty hunter Dr. King Schultz in Django Unchained.
Jordan Strauss/Invision/AP
Sally Field
She left the Globes without a win, but Sally Field's performance as Mary Todd Lincoln — opposite Globe winner Daniel Day-Lewis — may yet provide the 66-year-old star with her third Academy Award.
Jordan Strauss/Invision/AP
Read more about the nominees and winners, their films and TV shows, in our blogs, reviews and articles:
- 10 Best Movies for Grownups, 2012 (slideshow)
- Hey Oscar, you forgot something! (blog)
- Argo (review)
- Jodie Foster (slideshow)
- Lincoln (review)
- Steven Spielberg: Looking for Lincoln (article)
- Girls (blog)
- Homeland and Silver Linings Playbook (blog)
- Flight (review)
- Les Misérables (review)
- Real ads from the Mad Men era (slideshow)
- Zero Dark Thirty (review)
- Arbitrage (review)
- All 2012 Movies for Grownups reviews
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|The muscles closer to the center of the body (proximal muscles) are usually more affected in spinal muscular atrophy than are the muscles farther from the center (distal muscles).
Spinal muscular atrophy (SMA) is a genetic disease affecting the part of the nervous system that controls voluntary muscle movement.
Most of the nerve cells that control muscles are located in the spinal cord, which accounts for the word spinal in the name of the disease. SMA is muscular because its primary effect is on muscles, which don't receive signals from these nerve cells. Atrophy is the medical term for getting smaller, which is what generally happens to muscles when they're not active.
SMA involves the loss of nerve cells called motor neurons in the spinal cord and is classified as a motor neuron disease.
In the most common form of SMA (chromosome 5 SMA, or SMN-related SMA), there is wide variability in age of onset, symptoms and rate of progression. In order to account for these differences, the chromosome 5 SMA often is classified into types 1 through 4.
The age at which SMA symptoms begin roughly correlates with the degree to which motor function is affected: The earlier the age of onset, the greater the impact on motor function. Children who display symptoms at birth or in infancy typically have the lowest level of functioning (type 1). SMA onset in children (types 2 and 3), teens or adults (type 4) generally correlates with increasingly higher levels of motor function.
For more, see Forms of SMA [1].
Chromosome 5 SMA is caused by a deficiency of a motor neuron protein called SMN, for "survival of motor neuron." This protein, as its name implies, seems to be necessary for normal motor neuron function. Its deficiency is caused by genetic flaws (mutations) on chromosome 5 in a gene called SMN1. Neighboring SMN2 genes can in part compensate for nonfunctional SMN1 genes.
Recent evidence suggests that a lack of SMN also may affect muscle cells directly.
Other forms of SMA (non-chromosome 5) are caused by mutations in other genes. For example, an X chromosome gene called UBE1 has been identified that, when mutated, causes X-linked SMA. Flaws in the cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) gene on chromosome 14 also have been found to lead to a rare form of SMA, called SMA-LED, which predominantly affects the leg muscles.
For more, see Causes/Inheritance [2].
SMA symptoms cover a broad spectrum ranging from mild to severe.
The primary symptom of chromosome 5-related (SMN-related) SMA is weakness of the voluntary muscles. The muscles most affected are those closest to the center of the body, such as those of the shoulders, hips, thighs and upper back. Special complications occur if the muscles used for breathing and swallowing are affected, resulting in abnormalities in these functions. If the muscles of the back weaken, spinal curvatures can develop.
There's a great deal of variation in the age of onset and level of motor function achieved in chromosome 5-related SMA. These are roughly correlated with how much functional SMN protein is present in the motor neurons, which in turn is correlated with how many SMN2 genes a person has.
Sensory, mental and emotional functioning are entirely normal in chromosome-5 SMA.
X-linked SMA caused by a flawed UBE1 closely resembles the most severe, infantile-onset form of chromosome-5 SMA — except that it also affects the joints.
Chromosome 14-related SMA due to mutations in the DYNC1H1 gene is not fatal. People affected by the disease typically experience moderate weakness, mostly in the leg muscles.
For more, see Signs and Symptoms [3].
In chromosome 5-related SMA, the later the symptoms begin and the more SMN protein there is, the milder the course of the disease is likely to be. While in the past, infants with SMA typically did not survive more than two years, today most doctors now consider SMN-related SMA to be a continuum and prefer not to make rigid predictions about life expectancy or weakness based strictly on age of onset.
Research has focused on strategies to increase the body's production of SMN protein, lacking in the chromosome 5-related forms of the disease. Approaches in this and other forms of SMA include methods to help motor neurons survive in adverse circumstances.
For more, see Research [4], SMA: Full Speed Ahead [5] and In Focus: Spinal Muscular Atrophy (SMA) [6].
[1] http://www.mda.org/disease/spinal-muscular-atrophy/types-of
[2] http://www.mda.org/disease/spinal-muscular-atrophy/causes-inheritance
[3] http://www.mda.org/disease/spinal-muscular-atrophy/signs-and-symptoms
[4] http://www.mda.org/disease/spinal-muscular-atrophy/research
[5] http://quest.mda.org/news/sma-full-speed-ahead
[6] http://quest.mda.org/series/focus-spinal-muscular-atrophy-sma/sma-research
[7] http://www.mda.org/disease-name/motor-neuron-diseases
[8] http://www.mda.org/disease-name/spinal-muscular-atrophy-sma