text:
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
Name: TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide. ..more
BioActive Compounds: 1149
Related Experiments
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center
Affiliation: The Scripps Research Institute, TSRI
Assay Provider: Bill Nelson
Network: Molecular Library Probe Production Centers Network (MLPCN)
Grant Proposal Number: 1 R03 MH098712-01
Grant Proposal PI: Bill Nelson
External Assay ID: MBD2-CPGDNA_INH_TRFRET_1536_1X%INH PRUN
Name: TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide.
Of all the somatic genome changes that accumulate during the pathogenesis of human cancers, only changes in DNA methylation appear to occur consistently (virtually all cases), to arise early (first appearing in preneoplastic lesions), and to be potentially reversible (the DNA sequence remains intact) (1-4). One such change in DNA methylation, increased CpG dinucleotide methylation at CpG islands encompassing the transcriptional regulatory regions of many genes, leads to the transcriptional "silencing" of critical cancer genes (2, 5-6). CpG island hypermethylation has been reported to inhibit gene transcription by interfering with the binding and/or function of transcriptional trans-activators, or by recruiting 5-meCpG-binding domain (MBD) family proteins capable of mediating transcriptional repression (7). As many as 500 or more genes are epigenetically "silenced" in most human cancers. Two MBD family proteins have been implicated in the silencing of genes carrying abnormally hypermethylated CpG island sequences, MECP2 and MBD2. MBD2 binds 5-meCpG-DNA and is a component of a 1 MD transcription repression complex that also contains a chromatin remodeling complex subunits, histone-binding proteins, and a helicase/ATPase domain (8). Evidence suggests that MBD2-containing complexes are responsible for transcriptional repression accompanying somatic hypermethylation at pi-class glutathione S-transferase 1 (GSTP1), the most common genome change yet reported for prostate cancer, and a common alteration in breast and liver cancers (9-11). The goal of this project is the discovery and characterization of small molecule inhibitors of epigenetic gene silencing mediated by MBD2 and thus to identify compounds that will be able to reactivate the silenced genes in cancer cells, restoring gene function.
1. Brooks, J. D., Weinstein, M., Lin, X., Sun, Y., Pin, S. S., Bova, G. S., Epstein, J. I., Isaacs, W. B., and Nelson, W. G. (1998) CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia, Cancer Epidemiol Biomarkers Prev 7, 531-536.
2. Herman, J. G., and Baylin, S. B. (2003) Gene silencing in cancer in association with promoter hypermethylation, N Engl J Med 349, 2042-2054.
3. Lin, X., Tascilar, M., Lee, W. H., Vles, W. J., Lee, B. H., Veeraswamy, R., Asgari, K., Freije, D., van Rees, B., Gage, W. R., Bova, G. S., Isaacs, W. B., Brooks, J. D., DeWeese, T. L., De Marzo, A. M., and Nelson, W. G. (2001) GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells, Am J Pathol 159, 1815-1826.
4. Nakayama, M., Bennett, C. J., Hicks, J. L., Epstein, J. I., Platz, E. A., Nelson, W. G., and De Marzo, A. M. (2003) Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection, Am J Pathol 163, 923-933.
5. Antequera, F., and Bird, A. (1993) Number of CpG islands and genes in human and mouse, Proc Natl Acad Sci U S A 90, 11995-11999.
6. Bird, A. P. (1986) CpG-rich islands and the function of DNA methylation, Nature 321, 209-213.
7. Bird, A. P., and Wolffe, A. P. (1999) Methylation-induced repression--belts, braces, and chromatin, Cell 99, 451-454.
8. Feng, Q., and Zhang, Y. (2001) The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes, Genes Dev 15, 827-832.
9. Bakker, J., Lin, X., and Nelson, W. G. (2002) Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells, J Biol Chem 277, 22573-22580.
10. Lin, X., and Nelson, W. G. (2003) Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells, Cancer Res 63, 498-504.
11. Singal, R., van Wert, J., and Bashambu, M. (2001) Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells, Cancer Res 61, 4820-4826.
PRUN, Primary, Primary screen, Methyl-CpG binding domain, MBD2, DNA binding domain, MBD2-CpGDNA, MBD2-CPGDNA, MBD2-DBD, MBD2-MBD, FAM CpG DNA, Lanthascreen Tb Anti-HIS antibody, gene silencing, epigenetic gene silencing, cancer, GSTP1, glutathione S-transferase 1, pi class glutathione S-transferase 1, FAM, carboxyfluorescene, primary, singlicate, confirmation, triplicate, dose response, biochemical, antagonist, inhibit, inhibitor, inhibition, inh, FRET, fluorescence, HTS, high throughput screen, 1536, Scripps, Scripps Florida, MLSMR, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN.
Assay Overview:
The purpose of this assay is to identify compounds that inhibit the binding of cloned recombinant 6-His-tagged DNA-binding domain of MBD2 (MBD2-DBD) to a FAM-labeled 14 bp hairpin oligonucleotide containing a symmetrically-methylated CpG, whose interaction is monitored using Tb labeled anti-his antibody. Pre-incubation of the MBD2 protein, FAM labeled methylated CpG oligo and Tb-labeled anti-His antibody leads to formation of a stable complex. Anti-his-complexed lanthanide (Tb) attaches to the anti-his-binding peptide tag on MBD2-DBD protein. When terbium donor is excited, Tb transfers energy to a fluorescein tag on the methylated oligo, now complexed with MBD2-DBD, resulting in an increase in TR-FRET. An inhibitor of the MBD2-DBD:FAM methylated CpG interaction will inhibit binding between MBD2 and FAM methylated oligo, leading to reduced energy transfer and reduced well FRET (fluorescein emission / Tb emission). Compounds are tested in singlicate at a final nominal concentration of 4.4 uM.
Protocol Summary:
The assay was started by dispensing 5 uL of Control Mix in assay buffer (4% glycerol, 1 mM MgCl2, 0.5 mM EDTA, 0.5 mM DTT, 125 mM NaCl, 10 mM Tris-HCl (pH 7.4), and 0.2% Tween-20) containing 25 nM of MBD2 protein, 30 nM of FAM labeled Unmethylated CpG DNA oligo and 5 nM of Terbium labeled anti-his antibody into columns 1 thru columns 3 of 1536 microtiter plates. Next, 5 uL of Experimental Mix containing 25 nM of MBD2 protein, 30 nM FAM labeled Methylated CpG DNA oligo and 5 nM Terbium labeled anti-his antibody in assay buffer were dispensed into columns 4 thru 48. Then, the plates were centrifuged and pinned with 22 nL of test compound in DMSO or DMSO alone (0.44% final concentration). The plates were incubated for 30 minutes at 25 C and TR-FRET was measured on a Viewlux microplate reader (Perkin Elmer, Turku, Finland). After excitation at 340 nm, well fluorescence was monitored at 495 nm (Tb) and 525 nm (FAM). For each well, a fluorescence ratio was calculated according to the following mathematical expression:
Ratio = I525nm / I495nm
I525nm represents the measured fluorescence emission at 525 nm.
I495nm represents the measured fluorescence emission at 495 nm.
The percent inhibition for each compound was calculated using as follows:
%_Inhibition = 100 * ( Ratio_Test_Compound - Median_Ratio_Low_Control ) / ( Median_Ratio_High_Control - Median_Ratio_Low_Control ) )
Test_Compound is defined as wells containing the Experimental Mix in the presence of test compound.
High_Control is defined as wells containing the Control Mix and DMSO.
Low_Control is defined as the median of the wells containing test compounds.
PubChem Activity Outcome and Score:
A mathematical algorithm was used to determine nominally inhibiting compounds in the Primary screen. Two values were calculated: (1) the average percent inhibition of all compounds tested, and (2) three times their standard deviation. The sum of these two values was used as a cutoff parameter, i.e. any compound that exhibited greater % inhibition than the cutoff parameter was declared active.
The reported Pubchem Activity Score has been normalized to 100% observed primary inhibition. Negative % inhibition values are reported as activity score zero.
The PubChem Activity Score range for active compounds is 100-11, and for inactive compounds 11-0.
List of Reagents:
MBD2-MBD protein (supplied by Assay Provider)
FAM labeled Methylated CpG DNA Oligo (IDT-custom order)
FAM labeled Unmethylated CpG DNA Oligo (IDT-custom order)
Lanthascreen Tb Anti-His Antibody (Invitrogen, part PV5895)
MgCl2 (Fisher, part BP214)
NaCl (Sigma, part S6546)
DTT (Fisher, part BP172)
EDTA (Sigma, part E7889)
Tris (Amresco, part 0497)
Tween 20 (Sigma, part P9416)
Glycerol (Sigma, part G7893)
1536-well plates (Corning, part 7261)
Due to the increasing size of the MLPCN compound library, this assay may have been run as two or more separate campaigns, each campaign testing a unique set of compounds. All data reported were normalized on a per-plate basis. Possible artifacts of this assay can include, but are not limited to: dust or lint located in or on wells of the microtiter plate, compounds that modulate well fluorescence. All test compound concentrations reported above and below are nominal; the specific test concentration(s) for a particular compound may vary based upon the actual sample provided by the MLSMR.
Categorized Comment - additional comments and annotations
From PubChem:
Assay Format: Biochemical
Result Definitions
** Test Concentration.
Additional Information
Grant Number: 1 R03 MH098712-01
Data Table (Concise)


text:
Hang tight!
Recipe by Elaine Thompson
"This recipe uses amaretto liqueur. It's a creamy cheesecake with a light almond flavor."
Hmm. None of these ingredients are on sale today.
Show ingredients on sale
Sort stores by
Save money at local stores when ingredients are on sale!
Watch video tips and tricks
1 cup
graham cracker crumbs
3 tablespoons
white sugar
3 tablespoons
2 (8 ounce) packages
cream cheese
1 1/4 cups
white sugar
3 tablespoons
1 (16 ounce) container
sour cream
1 1/2 teaspoons
vanilla extract
5 tablespoons
amaretto liqueur
1/2 teaspoon
I've made this cake several times, and have gotten rave reviews from it: even my mother, who usually dislikes cheesecake, loves this one.
The ingredients and proportions in this recipe are perfect - don't change a thing! The baking time, however, is a problem: don't bake this only for an hour then take it out of the oven, you'll end up with a half-cooked heavy mess. I bake it for 52 to 55 minutes, *shut off the oven*, then leave the cake in for another hour and five minutes. This will cook the cake completely and prevent it from cracking while it does so. Allow the cake to cool before putting it in the fridge, and *leave it there* for a day - it'll taste divine.
This cake is very light and creamy, and tastes wonderful. The recipe is definitely a keeper.
I love Amaretto & wanted to make a nice cheesecake for a catered event. I made a practice cheesecake & was disappointed--the cheesecake was too dense, not enough almond flavor, and the crust was a little skimpy. When I made the 2nd cheesecake, I made a few changes when also enabled me to used a 10" springform pan, instead of a 9" pan: (1)For the crust,I used 18 crushed graham crackers, 1/4 cup sugar, 6 tbsp butter & 1/2 tsp almond extract (I'll use gingersnaps next time); (2) I used 3 8oz pkg of softened cream cheese instead of 2 pkgs;(3)reduced cornstarch to 1.5 tablespoons; (4) added 1/2 tsp almond extract to the cheescake batter; and (5)added 1/3 cup toasted slice almonds as a garnish to the finished cheesecake. Everyone loved the appearance, flavor and texture of the cheesecake. Also, baking the cheesecake in a water bath is must---no cracks!
92 Ratings
This recipe was very good when I tweaked it a bit based on other reviews. I didn't have all of the ingredients listed, so I made some changes. I used vanilla wafers instead of graham crackers for the crust, and Splenda for baking instead of the sugar in the crust, along with doubling the amounts of the crust ingredients. I also exchanged 8 ounces of sour cream for 8 ounces of plain lowfat yogurt, and used Neufchatel cheese instead of cream cheese. I used 1/2 cup of Splenda for baking along with 3/4 cup of sugar for the batter. I also used 1/3 cup of amaretto instead of the smaller amount in the original recipe.
When baking, I used a 10 inch springform pan and baked it in a water bath. No cracking! I added an extra 5 minutes to the baking time because the extra amaretto made the batter a bit thin.
After it was cooled, I made a glaze from 2 and 1/2 Tablespoons melted butter, 1 cup confectioner's sugar, 1 Tablespoon amaretto, and 1/4 cup chopped almonds.
The cheesecake turned out wonderfully light and delicious! Everyone agreed that this tweaked recipe is a keeper!
I made this yesterday and it was very good, but even tho I baked it as long as it said and left it in the oven, it cracked when I took the spring form pan off. No big deal I guess. It was 'fluffier' than I expected it to be. I love the super dense texture of traditional cheesecake. I suppose it was the sour cream instead of a 3rd pkg of cream cheese. The company raved about it anyway.
Good cheesecake base, but i was expecting more amaretto flavor. I added about a 1/4 of a cup amaretto and baked it for 5 extra minutes. The cake turned out fine, very smooth, but still didn't feel as though it was flavorful. I might suggest topping the cake with an amaretto and sugar "glaze" to really get the flavor.
Delicious cheesecake!!! my first attempt and this was absolutly amazing. I followed the previous tips and it worked out really well
This is my hubby's favourite cake. I make it for him every birthday. I also add a bit more amaretto, I've also added almond extract when I ran out of amaretto, both tasted devine. Trick to stop cheesecake form cracking is bake in water bath I do it every cheesecake recipe and never get cracking I also baked 55 mins and left in oven for hour after turned off.
Very good cheesecake, but not the best Amaretto Cheesecake I've tasted/made. I followed the directions exactly with the exception of adding a bit more liqueur. The flavor of the cheesecake was phenomenal. The texture is quite dense, which I don't mind, but the cheesecake was a tad dry. Next time I will consider either using less sour cream, or adding more cream cheese. I baked for 55min, shut the oven off and left it in there for an hour before taking it out of the oven. I got rave reviews from friends and family though!
* Percent Daily Values are based on a 2,000 calorie diet.
Amaretto Cheesecake I
Serving Size: 1/12 of a recipe
Servings Per Recipe: 12
Amount Per Serving
Calories: 417
Calories from Fat: 236
We have so many top-rated chicken recipes, you'll never run out of dinner ideas again.
Imagine dinner making itself in the slow cooker while you relax or do other things.
Delicious recipes, party ideas, and cooking tips! Get a year of Allrecipes magazine for $7.99!
Chocolate cheesecake gets a delicious Irish makeover.
See how to make a rich, marbled pumpkin cheesecake flavored with Kahlúa.
See how to make a classic cheesecake in five easy steps.

subset: commoncrawl


text:
15 November 2010
Posted in Offsite Programs
Kind words from our friends in St. Cloud. It's always nice to hear we're making an impact!
"On behalf of the St. Cloud High School Health Science Department I want to extend our thanks for including our program in the Regional Nursing Career Pathway Initiative. Your presenters were fabulous and the curriculum exciting!"


text:
Awards are nice, but they're not what keep your feet warm and dry during a hard hike in the snow. Take a lightweight performance boot and winterize it with 200g of 3M™ Thinsulate™ insulation and an UltraDry™ waterproof liner. Attach it to the earth with a Vasque Blur sole. Welcome to winter…and a limitless horizon to pursue. Oh, and the award? Backpacker Magazine Editor's Choice for 2012. We'll take it…and the hike, too!
7.5 |
8 |
8.5 |
9 |
9.5 |
10 |
10.5 |
11 |
11.5 |
12 |
13 |
A 1.4mm waterproof PU coated leather seals out the elements and is combined with a waterproof, tightly woven textile mesh for excellent breathability during aerobic pursuits. The molded heel yolk provides stability on uneven terrain. A warm fleece collar lining, 200g of Thinsulate™ insulation and our proprietary UltraDry™ waterproof membrane deliver cold weather comfort.
The Vasque Blur sole is adapted from our trail running product, creating a lightweight, stable and well-cushioned ride, utilizing dual density molded EVA, molded TPU instep plate and a pliable textile forefoot plate. The rubber sole has an aggressive lug pattern with the perfect balance between toothy bite and lightweight speed.
The Adirondack Mountains in New York include 46 peaks with elevations above 4,000 feet. Those adventurous enough to summit 550 of the Adirondack peaks in the snow, cold, and wind between December 21st and March 21st attain "Winter 46-er" status. Jim Wallace is one of those. Find out the inspiration behind his transformation from 240 lb. pack-a-day smoking summit failure to a full-fledged Winter 46-er. "When you get to the top of the summit, and you see all the peaks around you...that is the answer. You feel, like, this is why I'm here."FIND OUT WHAT'S WITHIN
Rooibos Tea/Magnet
Features: Insulated | Waterproof
Turkish Coffee/Bone White
Features: Insulated | Waterproof
Turkish Coffee/Russet Orange
Features: Insulated | Waterproof
Snow Junkie UltraDry™
You can purchase this shoe by using one of the following options:
Select your size and we'll let you know which websites have it in stock.
Please call ahead to see if your favorite style is available!FIND A STORE
Compatibility View
You are using a version of Internet Explorer whose Browser Mode and Document Mode are not allowing correct display. Please press your F12 key and set Browser Mode and Document mode to the highest versions available.
This site is not compatible with versions of Internet Explorer older than 8. Please update to a newer browser version or use an alternate web browser e.g. Mozilla Firefox or Google Chrome.×


text:
Capturing the beauty of the ocean and the power of the wave like you've never seen it before! One of the great masterpieces of his legendary surfing photography career, Woody Woodworth added this print to his Creation Captured series for its artistic merit and historical significance (one of his first great shots, this one has been published countless times in publications around the world). A Southern California classic, perfect for the wall of anyone who loves the Pacific Ocean, surfing, pastel colors, and great nature photography!
Product Specifications:


text:
Posted On:
13 March 2013
Posted By
Ari Suryaputra
Categories :
Culture and Heritage
Wayang Orang Bharata: A Javanese Theater Surviving in Jakarta
Posted on : 13 March 2013
Categories : Culture and Heritage
I remembered, a few years ago, when visiting Solo City, I saw a wayang orang show at a local theater. Wayang orang is Javanese classical theater performance with themes taken from Mahabharata or Ramayana epics.
Seeing the locals, adults or even children, came to watch and enjoy the show till midnight was actually awesome for me. That was a place where people come to appreciate traditional cultures… their own heritage. That day, I believed that such shows—although look boring for a modern standard—will always exist in this country.
Last week, my friend, Abi, invited me to see Wayang Orang Bharata's performance. This group bases in Jakarta and performs regularly every Saturday night. Shame on me… although living in Jakarta, I never saw their performance before. I—maybe like other Jakarta-born guys—often underestimate the traditional cultural groups; some of us maybe do not know that such groups exist here. Lucky me, I grew up in a Javanese family who still keeps tradition. I know a little bit about the wayang stories, mostly from my father, and several times watch Ramayana ballet or shadow puppet shows. But still, it is my bad record for missing this Wayang Orang Bharata's performance.
So I came to the show yesterday. They performed in their newly renovated theater house. It was located in Pasar Senen District, Central Jakarta. I have to say, surprisingly, it was clean and nice. Also, I was amazed with so many people came to watch it that night. In front of the building, three-row cars were parked. And inside, seats were almost full… the VIP class, the first class, or even the balcony.
The show was started at 8.30 p.m. They performed "Bagong Kembar" (Bagong Twins) that night. All dialogues were in Javanese, but a running text was provided in Bahasa Indonesia.
I enjoyed the show. The fight scenes were cool and very entertaining. The comedy was smart; they made funny political jokes and brought several social issues. The costumes were superb, the lighting was just perfect, sound system was good, and the air conditioner worked well; I absolutely love their performance! Okay… before it's too overrated, I need to admit that it was not an international-standard opera house. But, c'mon guys, for a traditional theater show, they fulfill the Jakarta's standard for sure.
It was unique that the show was not like a common theater show we knew. There was no strict rule. The guests could take pictures during the show. We could order foods and drinks; then the sellers would come to serve us. People laughed loudly when the actors made funny things. In the comedy scenes, some of them threw boxes of cigarettes to the stage—sometimes it was money inside—showing their tribute to the actors. I thought those were very humble and warm instead of being rude. It was like you attend an outdoor movie night. You come, eat your snack, mingle with others, and the only rule is "enjoy the show".
So, I enjoyed the night. It was a great experience to see a traditional theater group live and survive in Jakarta. A must-see performance where we will fall in love with a humble cultural show in this modern invasion era.I,once again,believed Wayang Orang Bharata as well as other traditional theater groups will always exist everywhere in this country.
Tag : Ramayana Ballet: A Masterpiece of Dance


text:
Category/Tags: Current Students Prospective Students Faculty/Staff Parents Community
Skidmore In The News
Economist Joerg Bibow writes about the Greek debt crisis
"The Euro was not meant to be a prison," says Professor Bibow in this essay for "The Conversation." More.
Professor Jim Kennelly advocates for the arts
Writing in the "Irish Examiner," Kennelly reminds readers of the importance of Ireland's cultural assets. More.
Dan Nathan talks to CNN about Baltimore, after the riot
American Studies Professor Dan Nathan, a longtime Baltimore Orioles fan, reflects on the healing properties of sport and a wounded city in this CNN story. More.
VP Bates recognized by statewide organization
Mary Lou Bates, vice president and dean of admissions and financial aid, is the recipient of the President's Award from the New York State Association for College Admission Counseling. More


text:
Jan 7 2013
Classic Duckworth Video Footage
This is how it all started. Watch this classic Duckworth video created in the early 1980′s by founder Ernie Duckworth and his wife and son. At the time, this was state-of-the-art production, shot on 8mm film and edited together with tape and a razor blade.
The video covers a number of different segments including one early jet boat run all the way to Hells Canyon Dam on the Snake River. The narration is just priceless. Please leave your comments on the YouTube. Enjoy and thanks for watching.


text:
All summer long you can enjoy engaging programs each and every day at the Hall of Fame through the KeyBank Summer Programming Series. Take a guided tour of the Hall of Fame Gallery, visit with a ballpark vendor to learn about the business of the ballpark, or get a close-up view of baseball's past with Artifact Spotlight programs.A full listing of daily program offerings are available at the ticket booth each day.
25 Main Street, Cooperstown, NY 13326Phone: 1-888-HALL-OF-FAME | Fax: 607-547-2044 | Email the Hall of FamePrivacy Statement/Your California Privacy RightsTerms of Use


text:
When it comes to exercise, you get out what you put in. So, when you devote a lot of work, you expect fabulous results. But, sometimes, the results of a workout are far from what was expected.
From surprise orgasms to black toes, a number of strange things can happen to the body when put through its paces. These issues often occur when the exercise is intense, when it lasts a long time and is atypical -- running a marathon, for example.
Many of the problems stem from simple nutrient depletion, as the body uses up fuel to sustain a tough work out.
"When the body is stressed, it reroutes resources, such as blood flow, away from non-vital systems," said Dr. Michelle Wolcott, assistant professor and sports medicine specialist at the University of Colorado at Boulder. "Muscles, particularly the heart and leg muscles, use up all available nutrients and oxygen."
Because of this, loading up on electrolyte salts or carbohydrates for energy won't solve the problem, and a person can go into a state of hyponatremia, in which the body cannot even process any nutrients.
Marathon and long distance runners seem to endure the bulk of odd side effects from physical exertion, although almost any activity done to excess can have adverse effects, from weight lifting to sports.
In general, however, weird phenomena resulting from intense exercise are out of the ordinary. It is rare that the average gym-goer would experience these problems.
"It's a distinct minority [of people] with a personality type that is probably very different," said Dr. Linn Goldberg, professor of medicine and head of the Division of Health Promotion and Sports Medicine at Oregon Health and Sciences University in Portland.
People who are adversely affected by a hard workout also often have underlying problems, such as a history of migraines, that make them susceptible to further issues.
Experts say the best way to exercise without side effects is to do it often, build intensity slowly and maintain proper nutrition.
"A little can be good, a lot does not mean it's better," Goldberg said.
The following is a list of some of the strange things that happen to the body during exercise.
Mystery or not, the female orgasm has an infinite capacity to surprise. The latest: orgasms making an appearance at the gym.
A phenomenon hotly debated on Internet message boards, many women claim to have orgasms while exercising, primarily during core muscle work, giving it the moniker "coregasm."
Crunches, hanging leg raises and other moves that tense and relax muscles surrounding the pelvis and the pelvic floor muscles seem to be the best triggers for coregasms.
"Orgasm is a physiological response," said Bean Robinson, associate director of the Program in Human Sexuality at the University of Minnesota Medical School. "We know some women who can have orgasms without any physical stimulation, just mental stimulation. ... It makes perfect sense to me that someone could have an orgasm [while exercising.]"
In addition, the pleasure hormones -- endorphin and dopamine -- that are released during exercise may contribute to coregasms.
But the phenomenon may still be rare enough to render the medical community skeptical. Few men have come forward with the same experience.
"I don't know of any science that supports that," said Dr. Ann Hoch, associate professor and director of the Women's Sports Medicine Program at the Medical College of Wisconsin.


text: Stay active while having fun! These active toys will encourage your child to move while they play and add more physical activities to their day. When playing sports, kids learn about teamwork. Parents can also teach them that winning isn't everything; the fun is in the playing. Most importantly, a kid's gotta' move! Choose from a fun assortment of sports toys and outdoor games for kids and families, plus remote control and interactive vehicles.


text:
A TED Talk That Might Turn Every Man Who Watches It Into A Feminist? It's Pretty Fantastic.
This is, hands down, my favorite TED talk of all time. That isn't hyperbole. I spent three days trying to pull out some highlights to share and ended up with a second-by-second recap of the whole dang thing.
Just hit play, and let the awesomeness wash over you (but especially pay attention around the 10-minute mark because that's when things get really good).
Note: This video discusses sexual and physical violence. Transcript below if you want to read ahead.
You should probably share this with all your friends. Especially if they're dudes. Just sayin'.


text:
Interpretive Handbook
70064 :
Renal Pathology Consultation, Wet Tissue
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The Mayo Renal Pathology service is staffed by board-certified pathologists who have a special interest in nonneoplastic diseases of the kidney.
Kidney biopsy has proven to be of value in the clinical evaluation and management of patients with kidney disease, including acute and chronic renal insufficiency, nephrotic syndrome, nephritic syndrome, proteinuria and hematuria, and in the overall management of renal transplant recipients.
Optimal interpretation of a kidney biopsy requires integration of clinical and laboratory results with light microscopic, immunofluorescent histology, and electron microscopy findings.
Useful For Suggests clinical disorders or settings where the test may be helpful
The evaluation and management of patients with kidney disease
Following the progression of known renal disease and/or response to therapy
Determining the cause of dysfunction in the transplanted kidney (allograft)
Interpretation Provides information to assist in interpretation of the test results
A verbal report of the findings is typically communicated by phone to the submitting nephrologist, and an initial report based on the light microscopic and immunofluorescent histology interpretation is also faxed to the nephrologist. A report is also sent to the submitting pathology laboratory.
Representative electron microscopy images and significant positive immunofluorescent stain findings can be provided on a CD upon request.
In most cases, the electron microscopy results are reported as an addendum and a final report is issued including these findings. This final report is again faxed to the submitting nephrologist and mailed to the submitting pathology laboratory, along with a representative set of the light microscopy slides.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Accurate and timely interpretation of a kidney biopsy requires integration of light microscopic, immunofluorescent histology, and electron microscopic findings with clinical and laboratory data. Failure to provide the relevant clinical history and laboratory results may result in a delay in the interpretation or the inability to adequately correlate the biopsy findings with the clinical picture.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.


text:
HOME Martin Truex Jr Gear Martin Truex Jr Mens Martin Truex Jr Mens T-Shirts (46 items) Product ID: 1120930
Main Content
This item ships within two business days.
Lap after lap, your driver and his vehicle make you proud. Show off your racing hero with this Gauge T-shirt from The Game. The chest features vibrant printed graphics of your NASCAR driver's name, team, and car.
- 100% Cotton fabric
- Crew neckline
- Made in Honduras
- Officially licensed
- Printed NASCAR driver, team, and car graphics on chest
- Short-sleeved T-shirt
Jr Customers also liked:
Reviewed by 1 customer
- Authentic Design
- Shows Off Team Pride
- Slow Mailing Service
Best Uses
- At The Race
- Daily Use
- Showing Team Pride
- Watching The Race
Comments about The Game Martin Truex, Jr. Gauge T-Shirt:
Great for the weekend.
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


text:
Tostitos Fiesta Bowl - January 3, 2013 - Oregon 35 - K-State 17This panorama of the 42nd Annual Tostitos Fiesta Bowl, taken by James Blakeway, spotlights a marquee matchup between two of the nation's best offenses and a pair of Heisman Trophy contenders, the Oregon Ducks and the K-State Wildcats. While both schools were on the heels of national title-contending seasons, in the end, the Ducks claimed victory with a final score of Oregon 35, K-State 17. This is Oregon's third straight 12-win season and their fourth straight BCS bowl appearance, the longest active streak in the country. The Ducks are one of only four programs nationally to qualify for four or more consecutive BCS bowls since the inception of the current system in 1998.
Welcome to University of Phoenix Stadium, and another glorious victory in the ever-expanding legacy of University of Oregon athletics! This spectacular poster features a post-game celebratory shot of the field just moments after the Ducks upended the Kansas State Wildcats for glorious victory. The perfect celebration of Chip Kelly's dynamic squad that featured Marcus Mariota, Michael Clay, De'Anthony Thomas, Kenjon Barner, Erick Dargan, and the rest of the team's greats! From the joy on the field below, to the split partisan crowd (half in ecstacy, half in despair), to the scoreboards, video screens, and unique stadium architecture, it's all here - the entire scene from the stadium, looking absolutely fantastic for your wall. Printed in brilliant color and perfect focus on high-quality paper stock, and complete with a sharp white border that includes the official Oregon team logo, the Fiesta Bowl game logo, the commemorative title, and a brief descriptive paragraph, this is both a beauty for the wall of home or office, and a great collector's item for years to come. Perfect for the wall of any fan of Oregon, Kansas State, and big-time College Football action!
Product Specifications:


text:
10 Oct 14
PharmiWeb.com is pleased to offer on-line training courses in partnership with ePharma Global.
Mike Wood
08 Sep 14
By Adam Sherlock, chief of strategic development, ProductLife Group
Adam Sherlock
28 Aug 14
If you've been through the interview and the recruiter says that inevitable question...Do you have any questions? - You don't want to be sitting there like a lemon, and mumble no. That won't win any prizes and certainly won't get you the job. So here are a few ideas.
Mike Wood
21 Aug 14
How do you know if your contact has opened the email you sent?
Mike Wood - Pharmiweb.com editor
14 Aug 14
European pharma to emerge as consolidators as US targets release key clinical data - Analysis
Mintoi Chessa-Florea, Surani Fernando and Eunice Ng
06 Aug 14
Wouldn't it be nice if there was a way to be notified by email as soon as something changes on your prospect's job pages.
Mike Wood - Pharmiweb editor
06 Aug 14
Gone are the days of cutting and pasting the job description and pretending it's a job advert. So here are a couple of tips…
Mike Wood - Pharmiweb editor
08 Jul 14
The job market has changed. Are you ready?
Phaidon International
02 Jul 14
Shaping the New Health Economy
Alan Garvey, Managing Director, EMEA, ESI International
23 Jun 14
10 Common Job Interview Lies
Mike Wood - Pharmiweb.com editor
19 Jun 14
In patients with locally advanced cutaneous melanoma who had all their lesions injected with the investigational agent PV-10 half achieved a complete response, reported a study presented at American Society of Clinical Oncology meeting, held in Chicago, Illinois, May 30 to June 2.
Janet Fricker
17 Jun 14
So far this year the total figure for global pharma transactions has reached $140bn, representing 13% of total M&A activity and second only to the technology sector in terms of the value of deals. Had Pfizer's bid been successful it would have been the biggest acquisition the pharmaceuticals world had ever seen.
David Press of DMJ Recruitment
17 Jun 14
Getting a job that needs experience you don't have
Mike Wood - Pharmiweb.com Editor
17 Jun 14
Applying for an internal position - don't get lazy
Mike Wood- Pharmiweb.com editor
30 May 14
Always check that your CV matches the job!
Mike Wood - Pharmiweb.com editor
12 May 14
Tendering is moving centre stage in the European Life Sciences marketplace. A recent Model N poll confirmed how businesses are aware of the growing importance of tendering and want to improve their performance. Many senior managers (51%) recognise the need to excel in an increasingly competitive tendering environment. A similar number (54%) point to its importance in increasing competitive intelligence, gaining a better understanding of what the customer wants and how competitors are responding.
James Robinson
06 May 14
A Cultural Fit?
Mike Wood - Pharmiweb.com editor
29 Apr 14
Generic vs. Brand Name Drugs: The Outlook 2014-2016
Áine Dunleavy
25 Apr 14
Don't rely on your boss to plan your career!
Mike Wood
26 Mar 14
Welcome to the Pharmiweb.com Job Search Series
Mike Wood - Portal Business Manager & Editor
21 Feb 14
Innovation Prize 2014 : Call for proposal is now open !
Léa Tourneur - Innovation Prize Officer
03 Feb 14
Most of us have heard the saying "It's not what you know, but who you know." Is it true?
By Julie Long
24 Jan 14
What's next after the interview?
Mike Wood, Pharmiweb.com editor
21 Jan 14
Analysis showing the extent to which the NHS is prescribing NICE recommended medicines is published today.
Health and Social Care Information Centre
16 Jan 14
The Interview
Mike Wood - Pharmiweb.com editor
14 Jan 14
Interview Preparation
Mike Wood - Pharmiweb.com editor
03 Jan 14
Your Cover Letter
Mike Wood- Pharmiweb.com editor
17 Dec 13
Amazon's top selling book of 2013 is StrengthsFinder 2.0, a book about self-assessment and career development!
Mike Wood
06 Dec 13
EPM Scientific have recently released their Relocation Motivations Report covering global relocation trends across the life sciences sector. Please see the key findings below.
Mike Wood
03 Dec 13
Pharma, biotech and medical devices organisations across South East Asia are at risk of losing over three quarters of their best people in the year ahead, according to a new report published by Real.
PharmiWeb.com is Europe's leading industry-sponsored portal for the Pharmaceutical sector, providing the latest jobs, news, features and events listings.
The information provided on PharmiWeb.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician.


text: Academic Advising and Support to our Students Staying true to our Jesuit mission, this office approaches advising and mentoring through the lens of educating the whole person and inspiring students to develop themselves as men and women for others. Here, a team of professionals guides students as they discern their futures, considering their academics as well as their values, abilities, career goals, and leadership potential. Within the Division of Student Development, this team supports the academic and co-curricular needs of students at distinct developmental stages, focusing on: Academic advising for students in all four years Support to faculty in their integral roles as first-year and upper division advisors and mentors A comprehensive Orientation program tailored to new first-year students, which begins at Summer Welcome and culminates in an extended four-day Fall Arrival A distinctive Orientation geared to the needs of new transfer and less traditional students Specialized advising for students who are exploring majors and for HEOP/AHANA and CSTEP students Well-developed first-year academic advising in the major with meetings at critical milestones in the first year Free tutoring and writing guidance during hours that match student needs so they can be the best students possible Residential learning communities for first-year students and sophomores who 'live, learn and lead' together through shared course work and interests Service learning opportunities that help to develop a life-long interest in civic engagement Specialized advising for international students while at Le Moyne A campus-wide early intervention system (EASE) for students who are academically at risk Our Mission We seek to help Le Moyne students succeed by providing them with comprehensive programs, services and support that will enable them to create meaningful connections and relationships within and outside the classroom to enhance their intellectual, social and personal development. Meet Our Team To enable us to provide the most comprehensive services to our students, our professional advisement team members are centrally located in 342-344 Reilly Hall. Office for Academic Advising and Support Susan Ames, Dean for Academic Advising and Support 315-445-4597 Allison Farrell, Director for Academic Advising and Support 315-445-4624 Liz Schylinski, Interim Assistant Director for Academic Advising and Support 315-445-4783 Duane Melzer, Advisor for Transfer Student Engagement 315-445-4775 Pamela Chrysler, Academic Services Specialist 315-445-4708 Karen Ortega, Administrative Assistant 315-445-4597 Mary Schad, Staff Assistant, Global Education 315-445-4624 HEOP/AHANA Program Ted Emmanuel, Director 315-445-4191 CSTEP Program Darshini Roopnarine, Director 315-445-4584 Seton Hall


text:
No one said training like a mad man is easy. Going yard day after day takes some serious work in the off season. DeMarini Yard-Work Training Gear is designed to help you train more efficiently. The Yard-Work Wordmark Training T is developed with wicking fabric to absorb moisture like sweat, blood, spit, and maybe a few victory tears. Designed with bleeding edge graphics that leave room for your logo or number. Go Yard.
DeMarini Sizing Chart


text:
If you're a gun owner, it is crucial that you help the NRA fight back. NRA EVP and CEO Wayne LaPierre stresses that "complacency is a sure path toward losing our rights." Defend the freedoms you enjoy and join today.
If you're a gun owner, it is crucial that you help the NRA fight back.
Theresa Vail is a beauty queen and avid hunter who also serves her country in the National Guard.
Chuck Holton spends much of his time in third-world countries and war zones, giving him a unique perspective on the U.S.
Spending her youth hunting gave MiMi Falb a unique appreciation for a hunter's role in preserving the natural world.
Veteran Air Force fighter pilot Scott O'Grady knows our freedom as Americans won't survive without sacrifice.
A match competitor and managing editor of GunUp, Shelley Rae works to promote a healthy shooting lifestyle.
Best-selling author Brad Thor is moving away from Chicago because of its widespread disrespect for gun owners.
Beauty queen turned self-defense trainer Nikki Turpeaux has recently joined the NRA News Commentator team.
"Top Shot" Champion Chris Cheng is sharing his experience as a gay shooter with others.
When Gabby Franco began shooting in Venezuela, at age 11, she had no idea how far it would take her.
Twenty-two-year-old Sarah Beard is following in her father's footsteps in hopes of Olympic gold.
Balancing two elite fighting careers keeps Tim Kennedy on his toes.
Retired U.S. Navy SEAL Marcus Luttrell discusses the importance of sharing the truth and honoring his brothers.
A political strategist, Laura Carno is using her media company to educate citizens about political topics.
NRA News Commentator Austin Weiss uses social media to educate about the importance of preserving rights.
Get to know Lena Miculek, one of America's top women 3-gun shooters.
When GunGoddess.com creator Athena Means hits the range, you'll recognize her as the lady with the bling!
NRA News Commentator Billy Johnson believes it's everyone's responsibility to stand up and speak out.
Mother and shooting instructor Tatiana Whitlock works tirelessly to get more women interested in shooting.
Not your typical high school student, Matti Warren is a vocal Second Amendment advocate.
On her way to a medical career, Ashley Hlebinsky stumbled upon something she enjoyed even more — firearms history.
NRA's Office of Advancement Executive Director Tyler Schropp works to defend our firearm freedoms.
Professional shooter Athena Lee was introduced to the sport in a small town in the Philippines.
Former U.S. Navy SEAL Aaron Reed has lived a life of service for his country.
A cop and 3-gun competitor, Dianna Liedorff believes the Second Amendment means what it says.
Avid hunter and shooter Kyle Weaver serves as Executive Director of NRA General Operations.
She's not your typical teenager. Meet Molly Smith, the 16-year-old Junior Captain of Team Smith & Wesson.
Haley Heath talks about hunting, kids and passing on a family tradition.
Champion shotgun shooter Jon Michael McGrath has won 22 world titles and nine national titles.
Rape victim Amanda Collins fights for the right of women to protect themselves and their families.
Josh Powell is a master-class sporting clays shooter who has competed all over the world.
Julie Golob is a 13-time USPSA Ladies National Champion and 7-time World Speed Shooting Champion.
A Second Amendment advocate and YouTube sensation, Colion Noir is a contributor to NRA News.
When Navy SEAL Dom Raso left the military, he knew his job of defending freedom wasn't yet finished.
Natalie Foster is the girl behind Girls Guide to Guns, as well as an NRA News Commentator.
Thirteen-year-old 3-gun shooter Katie Francis shoots in competitions around the country.
J.R. Salzman first shot a gun at age 8, and he's used guns to defend his life and the lives of fellow soldiers.
Cam Edwards is host of the Cam & Co. show, seen and heard on NRA News, Sportsman Channel and SiriusXM.
Kim Rhode is the only American to ever win an individual medal in five consecutive Olympic games.
This trapshooter has won medals all over the world, including bronze in the 2008 Olympics. Meet Corey Cogdell.
Jessie Duff is one of the most accomplished shooters — male or female — in America today.


text:
Janus Capital Group has launched the Janus Diversified Alternatives Fund (DAF), which will bet on the equity, fixed income, commodity, and currency asset classes.
All Bank Investment Consultant articles are archived after 7 days. REGISTER NOW for unlimited access to all recently archived articles, as well as thousands of searchable stories. Registered Members also gain access to exclusive industry white paper downloads, web seminars, blog discussions, the iPad App, CE Exams, and conference discounts. Qualified members may also choose to receive our free monthly magazine and any of our daily or weekly e-newsletters covering the latest breaking news, opinions from industry leaders, developing trends and growth strategies.


text:
Calling all music lovers: this headphone's for you. The pinnacle of the XBA Series, these XBA-4 in-ear headphones boast a total of four Balanced Armature driver units (a full range driver, tweeter, woofer and super woofer) to deliver an incredibly balanced spectrum of crisp, radiant highs and deep, breathtaking bass. Precision engineered for music enjoyment, brace yourself for a premium listening experience like no other.
Designed for discerning audiophiles, XBA Series in-ear headphones are outfitted with Sony's newly developed Balanced Armature driver units engineered for crisp, balanced sound of incredible depth and precision. Infused with premium audio technology, even the most subtle musical nuances are delivered with tremendous clarity and detail.
Meticulously pre-tuned by Sony engineers, four Balanced Armature driver units (full range, tweeter, woofer and super woofer) reproduce a broad, finely balanced range of sound—from soaring highs to bellowing bass, and everything in between. Plus, these micro-sized drivers are engineered to emphasize key sound characteristics to enhance your music.
A specially made inner housing constructed of liquid crystal polymer holds the driver units rigidly in place for super smooth frequency response. Enclosed in an ABS outer housing that suppresses unwanted vibrations, this innovative double layer design delivers crystal-clear mid to high range sound and overall crisp, rich audio.
Because Balanced Armature drivers sport an ultra compact design for a smaller overall form factor, they slip easily inside the ear for a snug, more natural-feeling fit. The result? Reduced ambient noise and long-lasting comfort and wearability—even after hours of non-stop listening.
Lock in the sounds of your favorite songs, and block out disruptive background noise. Because Sony XBA Series in-ear headphones boast a noise-blocking design and a snug, comfortable fit, they prevent sound leakage—both in and out of the ear—so you can enjoy your music without annoying your neighbor, and get lost in a distraction-free listening experience.
With four sizes of hybrid silicone and three sizes of noise isolating ear cushions included, you can choose the best fit for your ears to maximize overall sound quality and comfort. With the perfect-fitting pair, your XBA Series in-ear headphones stay securely in place—even during strenuous exercise—while keeping ambient background noise at bay.
Sony Customer Care
Customer Service
Call us at 1-877-865-7669
Product Support
Learn & Share
Protection PLUS
Sony's got you covered. Choose from various Extended Service Plan options at the same time you purchase your Sony products to maximize your coverage.Learn more
In-Store or In-Home Support
Regardless of your location, Sony Premium Service Experts can support you. Just call us 24 hours, 7 days a week. If you prefer convenient face-to-face service, we'll come to you.Learn more


text:
You have no items in your shopping cart.
*One coupon per order. Excludes DoorBusters, Expanded Assortments.
1 Review(s) | Add Your Review
Show more
In stock
*Required Fields
NOTE: This item is an Expanded Assortment*. Please allow 3-4 business days for item to leave the warehouse.
Returns will be imposed a 15% restock fee. Item is NOT eligible for
promotional discounts.
Email to a Friend
(Posted on 6/8/2015)
I can wear these all seasons


text:
Two more new national polls released Thursday point toward a presidential election that could divide the nation along racial lines at least as sharply as the 2008 campaign.
In 2008, Barack Obama became the first candidate ever to lose whites by double digits and win the White House (John McCain beat him among whites by 55 percent to 43 percent), on the strength of support from a cumulative 80 percent from all minority voters.
Several national surveys released earlier this week showed Obama displaying patterns of support reminiscent of 2008, but facing the likelihood of erosion among whites-and the possibility of an even wider racial chasm.
The first University of Phoenix/National Journal Next America Poll and the latest Quinnipiac University national survey, both released Thursday, closely track the picture of those earlier surveys. Obama leads 50 percent to 42 percent in the Next America Poll (which was conducted from April 5-11, before other surveys that have shown a closer race) and 46 percent to 42 percent in the Quinnipiac survey. But when the white electorate is viewed through the lens of gender and education, each poll shows him facing strong headwinds among all but one group.


text:
DE-CIX New York: 111 Access Points
We'd like to welcome you as a customer to New York's game-changing carrier-neutral Internet exchange. This new exchange is wholly owned and operated by DE-CIX North America Inc., a wholly owned subsidiary of DE-CIX International AG, the international arm of DE-CIX.
DE-CIX New York is a carrier- and data center-neutral Internet exchange distributed across major carrier hotels and data centers throughout the New York/New Jersey metro. The exchange supports settlement-free interconnection between Internet backbones. Announced in September 2013 and first opened for customer orders in November, DE-CIX New York continues to add data center sites to expand the coverage of the exchange and increase its utility to the Internet peering industry.
We are committed to making the New York/New Jersey metro market a better place for ISPs and carriers by providing premium Internet exchange services in all key facilities in the metro. With 110+ access points in key facilites, DE-CIX New York is just a cross connect away from many hundreds of ISPs and carriers.
About DE-CIX
DE-CIX provides premium IX services to all kinds of networks and operates several carrier neutral and independent Internet exchanges (IXs) in the world, including DE-CIX Frankfurt, the world's leading IX.
Founded in 1995, DE-CIX provides the infrastructure for direct and settlement-free IP interconnection, called peering, and serves 700+ carriers, ISPs and content networks from 60+ countries in Frankfurt (Germany), New York (USA), Dubai (UAE), Palermo (Italy), Marseille (France), Istanbul (Turkey), Hamburg (Germany) and Munich (Germany).
DE-CIX operates the industry's most robust and advanced peering platform DE-CIX Apollon. All types of ISPs including broadband providers, content delivery networks, web hosters, and incumbent operators use DE-CIX services to improve their IP performance and lower their IP Transit costs.
Telegeography ranked DE-CIX Frankfurt the No.1 Internet traffic hub in Europe, making the city the perfect spot to establish peering connections. DE-CIX serves customers in 18 data center facilities in Frankfurt, including Equinix, Interxion and TelecityGroup.
DE-CIX is strictly carrier neutral and is owned by the eco association, the largest Internet industry association in Europe. DE-CIX is committed to serving the Internet community by providing world class Internet exchange services and professional, friendly and courteous service at all times.


text:
2015 Goals:
1) Win the next game.
2) See goal #1
"The problem with internet quotes lies in verifying their authenticity."
-Abraham Lincoln
Gettin' ****ed the **** up tonight!!!!!!!!!
Irish wake style.
One of my good friends passed away Saturday night/Sunday morning ... Went in his sleep at 52.
R.I.P. Mark Bane
Left the funeral parlor earlier, & went straight to the local watering hole where we used to hang.
I'm drinking Molson Golden in honor of my friend. (****ing Cowboys fan )
... Gonna be a loooong day at school tomorrow.
Hmmm ...
It would appear that 'ol Bump has been neglecting the Club lately. Whoops.
It's not because I've gone sober.
... Anyway, currently polishing off Coors Light #3 after work, and on to #4 while watching the puppy run around the back yard. Late October days like this are awesome - mid to low 70's right now in WV's scenic northern panhandle. Sitting on the deck, leisurely drinking some brews ... Life is good.
According to the pile of empties on the table ...
Cracking open #9.
This thead had been sadly neglected. Im god knows how many beers deep. Good times. Football, turkey and beer. God bless america
I'm *burp* full ...
Yet, somehow, it seems there's always room for beer!
Im nirmally annoyed when the bahamas tries to adopt US culture, but hanksgiving is one thing we copied from you guys that im glad of. Wasnt home for this one but its always been one of my favorite holidays growing up.
Been drinking homemade stout aged in oak barrels. Holy ****ing goodness. Gotta give my bro-in-law credit for that batch of brew!
"Frank's Redhot - I Put That **** On Everything!" ~ Ethel


text:
Neil Patrick Harris�is already God's gift to awards shows, so he may as well be a gift to your friends and family as well.Harris, the current undisputed king of hosting awards shows, got a little cocky—in a charming way, of course—in his first promo for his gig as Oscars host. The�How I Met Your Mother�star and...
Christmas came right on time for fans of�Doctor Who's companion Clara. After
Pam Oliver will miss the action, the fans and the security guards who sneak her into secret rooms for...
Dave Granlund cartoon about the Democrats in 2015.
As the U.S. government weighs its next step in a broader government response to a damaging cyber attack on Sony, President Obama ramped up his criticism of the Hollywood studio for its decision to pull back the release of �The Interview,� saying the...
It�s been a grand year for going to the movies.
Florida has passed New York to become the third most-populous state as it adds about 800 people per day, according to the U.S. Census Bureau.
- Events Calendar


text:
Hang tight!
Recipe by Tasneem
"I learned how to make this while visiting my husband's family in Syria. It can be a healthy, fast, easy vegetarian/vegan main dish for lunch or dinner that is surprisingly filling when eaten with pita bread, or it can be a flavorful side dish."
Hmm. None of these ingredients are on sale today.
Show ingredients on sale
Sort stores by
Save money at local stores when ingredients are on sale!
Watch video tips and tricks
1 (16 ounce) package
frozen cut green beans
1/4 cup
extra virgin olive oil
salt to taste
1 clove
garlic, minced
1/4 cup
chopped fresh cilantro
I tried this recipe with fresh green beans. I cut them up and soaked them for 5 minutes in salt water, then followed the recipe as advised. It was great! I served it as a side dish to pork chops and pasta! Would definitely do again.
212 Ratings
These were the most delicious green beans I've ever had! Took them to our family Thanksgiving potluck in which I was in charge of vegetable side dishes. Made these, and others from Allrecipes: the feta-bacon green beans (not so good) and the roasted brussel sprouts (awesome)
The only change I made was to use fresh green beans, about 1 lb, which I partially cooked in the microwave for about 5 mins first w/a bit of water, then I drained and proceeded w/the recipe, just sort of stir frying them w/the oil, garlic and adding the cilantro at the end, after the beans had gotten nice and dark. Not a pretty recipe, but so delicious. Never would have thought of cilantro and green beans together, but was absolutely delicious --I couldn't get enough of them, and they were excellent reheated the next day in the microwave! Will DEFINITELY add these to my veg. side dish favorites. Such simple ingredients and preparation, but a wonderfully complex flavor!
This has become my favorite way to prepare green beans. I was amazed at how big an impact the cilantro had on the end result I think I even use close to half cup of cilantro. I try to be careful with the oil, because I don't like me beans very oily. I also like to turn the heat up a little the last few minutes and brown the beans slightly. Make sure to keep stirring if you turn the heat up.
Excellent, light, tasty and easy recipe! i Don't usually like green beans, but Loved these! Served with filet mignon-- great combination. Cilantro gives perfect accent! Thank you Tasneem! :)
What a delicious recipe! Something about the oil does a wonderful thing to the beans. Don't mistake this for any ol' green bean recipe. This is the best!
Very good! I like this method of making green beans. I would suggest a lower "medium high" for the heat, though. **EDIT** I love this way of making green beans so much now that I hardly ever make them any other way. WOW!
I've been making these for about five years now, and have never written a review. This is a great recipe. Delicious just as is, but I usually add a touch more garlic to my personal taste. Yum! Try it- you won't be disappointed!
* Percent Daily Values are based on a 2,000 calorie diet.
Fasoliyyeh Bi Z-Zayt (Syrian Green Beans with Olive Oil)
Serving Size: 1/4 of a recipe
Servings Per Recipe: 4
Amount Per Serving
Calories: 164
Calories from Fat: 126
We have so many top-rated chicken recipes, you'll never run out of dinner ideas again.
Imagine dinner making itself in the slow cooker while you relax or do other things.
Delicious recipes, party ideas, and cooking tips! Get a year of Allrecipes magazine for $7.99!
See how to make a quick-and-easy green bean side.
Green beans simmer with tomatoes and onions until tender and yummy.
Thick or thin, whole or French cut, raw or cooked, green beans are the best side.


text:
The first round of presenters for the 2013 CMT Music Awards have been revealed, with a roster of personalities spanning from TV favorites Charles Esten (of "Nashville" fame), Duane "Dog" & Beth Chapman and comedian Larry the Cable Guy, to country stars Keith Urban, Kellie Pickler, Scotty McCreery and Florida Georgia Line, and other welcome surprises such as Kevin and Michael Bacon of the Bacon Brothers and Lisa Marie Presley.
The stars will present awards during the show - taking place at Nashville's Bridgestone Arena on June 5 - between songs from previously announced performers Carrie Underwood, Darius Rucker, Florida Georgia Line, George Strait, Hunter Hayes, Jason Aldean, Keith Urban, Lady Antebellum, Little Big Town, Luke Bryan and Taylor Swift.
Jason Aldean and Kristen Bell co-host the show, which will air live on CMT at 7 p.m. CT. Those in the Nashville area can see the show live - tickets are $35-$99 and available at Ticketmaster.


text:
This conversation is closed.
If we could rely on people to be honest, objective, intelligent, and reasonable, would we need any rules at all?
Expanding the idea that we should expect moral individuals to know when to break or expand the rule base, couldn't we also expect people to know what is right and fair based on their own sense of morality. Simply applying the 'golden rule' to know that if we were on the receiving end of our own actions that we would find them unfair, unsafe, or unreasonable. Ignoring whether this is possible or not, would such a hypothetical culture be able to resolve differences based only on the law of reason and fairness?
Feb 3 2013: Know what's weird?
The fact that we might not have a 100% rule-free world or society, but rather
have one that might have very, very few rules, because they are no longer needed,
doesn't seem to interest many. Odd, that.
Why is it necessary to throw out a good idea, or not work towards it, simply because it wouldn't produce
I have asked many if they are interested, or would be, or do they think the world would be a better place without crime and they say, "yes!"
But when I suggest ridding ourselves of the major causes of and for crime, they dismiss it almost immediately because they don't believe it would reduce crime to a 100% successful reduction rate.
It's gotta be 100%, perfection, or nothing, and I can no longer engage with them in discussion about how much better we all would be if crime were reduced by 90% or higher.
They want all the answers now, all the problems foreseen and solved, before they will take a chance at even thinking about something new, which only serves to keep them in their little coffin box of thought and action, which is always no action, no results except the same 'ole, same 'ole.
In order for your idea to work, and it can be implemented, we as a species must get rid of the reasons or causes for crime, corruption, unethical behavior and so on. People just refuse to think in that realm.
"What? Get rid of the causes? How is that gonna help? What a ridiculous idea!"
Of course, getting rid of the causes also eliminates the behavior and the need for most rules to rule by.
We, as an animal, do not act badly because it is our nature. We act the way we do because our genes give us choices on how to respond depending upon to what degree our environment is supporting us, can support us or is failing in any area upon which we as said animal, depend.
We're a higher animal, most will agree, but then we follow like sheeple as TED Lover said, and live like wild animals to survive, never eliminating the causes that push us around.
Feb 3 2013: I am confused. Why do you say that people are not interested in making improvements that are unlikely to have a 100% success rate? Isn't change of ANY kind in this category? Or do you mean a particular suggestion doesn't attract a lot of interest?
Who says or believes that getting rid of or reducing the reasons for crime, corruption, and unethical behavior isn't a pursuit worthy of thought, effort, and action? These issues are discussed all the time here and in arenas of policy action. Or again is it a particular strategy that people don't find as promising as others they consider more seriously?
Why do you say there is little interest in reducing rules and regulations? Even on TED, ideas along these lines are put forward and discussed by many people regularly and many people's campaign platforms in the US, at least, are based very much on this idea. Ronald Reagan was the first I remember really to emphasize this, but others probably did before him as well.
Feb 4 2013: Hi Fritzie
Well, people I talk to. All kinds of people, mainly westerners, so that is mostly what I hear in return.
I guess, as usual, I made some of my "blanket statements", from emotions.
Sorry about that.
For myself, speaking face-to-face with others, the usual response I get, and it is on a variety of topics such as what is discussed here on ted, is a quick dismissal and then a refusal to discuss further.
I would like to add to this however, that it seems to me that many seem to forget (based on their comments like, "Let's say I tell you with honesty, intelligence, objectivity, and reasonableness that I am going to scratch your new car because it will relieve the feelings of jealousy and disappointment I have been experiencing since you were promoted instead of me." from Mr. Long, overlooks the idea that by getting rid of causes and reasons, we will get rid of the type of behavior he uses as one example of an argument, that the topic can't work or won't work.
Training ourselves can help but changing the system we slave around in would do what we really want and need...eliminate what we need to eliminate. There would be no reason for behaving badly towards others, most of the time and in most ways, that we currently have by the ton.
Feb 4 2013: I understand now, RC. I have experienced frustration at how a team/community of pretty large size can be working very much as Reef describes- on the basis of honest, commited, and creative dispositions and hard work toward meaningful goals... and then a couple of people move in with their own self-interested agendae and muck up the whole works entirely. It can be somewhere between depressing and traumatic.
In fact it's maybe the biggest challenge in community building.
I think in many circumstances, though, the vast majority of people want to live and work in that sort of cohesive, tolerant, and constructive community and it's a few who don't care as much about that as they do in their own power or whatever.Feb 3 2013: In Acting what you described would be called magical 'if'. If such a world existed, there would be no need for rules.
But, yeah, we live in the real world.
Feb 3 2013: Very true, but there are so many questions, in every branch of thought, where the answer to a hypothetical can help shed light on real questions, even when the idea is an impossible ideal.Feb 3 2013: The key here, I think, is what is included in 'reasonable.' There are cases in which what is best for different people taken individually is in conflict, and there are different reasonable ways of making choices in such circumstances, depending on people's values. Also people will weigh the priority on certain values differently, which affects the choices they think are best for the aggregate.
In another conversation, though I don't remember which, a TEDster raised the idea that people within well connected small communities are able often to live without reference to rules and laws. Many loving families have such a format, for example, and many work places as well.
There are opposing forces. Some people by personality are quite apparently very ego-bound, whether or not they recognize this in themselves. I am not sure where you see the interface between such a personality attribute one sees in so many and the characteristics you put forward as conditions.
Your question is important, and many who in various contexts work with or work to build sustainable and vigorous communities consider all the time and seriously how to create and maintain a culture that operates on the basis of attributes such as those you put forward and very few rules. It definitely works in many situations.
Feb 3 2013: So then why is it that we can be reasonable with family and loved ones, but not with everyone else? I believe it is for exactly the reasons discussed here: that when honesty and objectivity are allowed to overpower bias based on pride and the need to be right (triumphant), reasonability is possible.
It's very true, that many choices favor one group or individual over another, but using a utilitarian accounting, even the 'losing' side, although disappointed with the reality, can often accept it as best for all.
I understand completely that there are many difficult complications, but I think those are the main differences between the family unit and society at large.
Feb 3 2013: Some people do better with their famiies and some actually do worst with their families! Some people find it easy to love or feel empathy for or to value those with whom they are not intimately connected and others don't.
I agree absolutely that people can weigh tradeoffs reasonably, take turns, and so forth if everyone is inclined or commited to functioning that way.
And then there are people who like to sabotage such situations. I have never understood why. Like most aspects of behavior, the answer likely lies somewhere in the individual's personality and history.
Feb 4 2013: I believe the answer is that too frequently people act on their emotions without due thought. I know this idea would be shunned by poets, play-writes, and artists who rely on emotional expression, and I admit that much beauty comes from uncontaminated emotional output. But so does much of the evil and pain we see.
The point of this thread is that I think if we train ourselves individually and expect each other culturally to take a moment to honestly evaluate our actions before we 'pull the trigger', a great deal of pain can be avoided.Feb 4 2013: Hi, Reef. I agree.
Feb 4 2013: Thanks for your helpful insights Fritzie. I'll look forward to more of the same in the future.Feb 3 2013: There are some behaviors missing from your description of citizens in a perfect Anarchy. Let's say I tell you with honesty, intelligence, objectivity, and reasonableness that I am going to scratch your new car because it will relieve the feelings of jealousy and disappointment I have been experiencing since you were promoted instead of me. Then I do it! Without rules I have committed no wrong. I was being honest (I am going to do it), objective (you were promoted because you play golf with the boss), intelligent (such acts of retribution do offer immediate alleviation of angst), and reasonable (though less qualified than me you got the promotion) but I acted only after considering how my deed would affect me. Without compassion, empathy, and social awareness I require rules to delineate what is acceptable behavior.
Feb 3 2013: I do like your label of this situation as a perfect anarchy. Possibly taken as disparaging because of the normal perception of anarchy, but apt nonetheless.
I disagree that you scratching my car could be honestly considered fair if you apply the golden rule though. If you say that you would feel honestly justified in the act, then you must also accept it as fair if you receive the same treatment from someone else. Compassion and empathy are critical elements in honest evaluation of an act if you truly with to avoid hypocrisy (ie honestly apply the golden rule). In honestly visualizing how we would receive the treatment we are considering giving to someone else, compassion and empathy should naturally and automatically come into consideration unless self-deception blocks them.
Feb 3 2013: My point is simply to point-out that your list of four behaviors is insufficient to allow a society to thrive with no rules whatsoever. Added to your list must be the characteristic of compassion, empathy, consideration, altruism, kindness, goodness, etc. whatever you choose to call it.Feb 3 2013: In fact, after more thought, I realize that empathy is the foundation on which the golden rule is based. Thanks for the thoughts.
Feb 3 2013: Precisely, so add Empathy to your list.
Feb 4 2013: I think that empathy, as contained in the golden rule, grows naturally from honest reason. When honestly deciding, we have to choose whether we will act in a way that would be acceptable from both the giving and receiving or not. Most often, as in your example, false justification is created using skewed facts and perspectives as I've described, so that when we tell the story to ourselves or others, we can appear empathetic even when we haven't been. The effort to appear so is made, at least in large part, so that we are not ostracized.
We could honestly choose to act in a way that we know we would not appreciate receiving, but then reason would warn us that, in a society in which we could honestly get away with such an act, we must expect it ourselves. I don't believe that reasonable people would choose the resulting chaotic culture.Feb 4 2013: All rightey then. With only the four behaviors listed in your headline I must answer "YES" to your question because there would be a need for a rule to control wrongdoing based on failure to consider others. I understand, but disagree with, your belief that selfish behavior is controlled by your four basic behaviors. Empathy is not subsumed in any of your four stated behaviors. Thank you for a provocative contribution. Be well sir!
Feb 8 2013: Same to you Edward. Very thought provoking, enjoyable, and hopeful to discuss such things with people like you. (Got this in the wrong place the first time.)
Gail .
Feb 3 2013: Of course not. But it's not as easy as that - however reasonable Mr. Schwartz's talk was.
- 0
Some years ago, my worldview CRASHED. In the twinkling of an eye, all that I had believed in was seen for the illusion that it was. It was all a lie - truth, justice, equality, freedom, and yes, even God. Not only was I devastated. I was crippled. Not knowing how to survive in the new world that I perceived, I didn't know what to do.
Should I go to work? Or should I just sit home and starve to death? If I go to work, I will be paying taxes that go to things that are morally abhorrent. Whether I looked at never-ending wars and pseudo wars, pollution & wanton waste of earth's resources, economic policy where I could have abundance, but only if I deprived someone else of it, or if I looked at laws that encouraged discrimination against others while calling it equality, I couldn't find a way to live without harming others, whether directly or indirectly. In essence, that which I had been calling freedom was really slavery, and I had been supporting my own slavery. That which I had been calling logical, WASN'T
Up to that point, my whole life had been spent suppressing that awareness. My entire culture is based on the people's willingness to hide from horrible truths about themselves and what they are doing to contribute to the horrors. The most successful are those who are most successful at hiding from awareness of consequences of their actions.
This is the systemic illness that pervades ours lives. So I ask, how does one say, "I will do "this" because it is right, and I will do "that" because even though it is morally repugnant, my survival depends on it. As soon as you are forced, in the name of survival, to make that second choice, one's willingness to look at his/her role is squashed.
When a society finds itself in that position - laws become necessary - to help people absolve themselves of responsibility for their own behaviors. People become sheeple.
Feb 4 2013: All true. My point is that one answer to all of this, that hacks at the root of the problem versus its branches, is self-honesty. We provide all of the self-deceptions you describe so that we can tell ourselves we are acting reasonably (fairly) and we use reality skewing techniques that mainly involve cherry-picking the whole picture to rearrage it in a way that appears to justify what we've done. Honesty and objectivity are the cure for this.
I disagree that people who do what you describe are the most succesful in the long run. I have no desire to be Donald Trump, no matter how rich that would make me. False lives have to be maintained at great mental and emotional cost. Often, when allowed to see throught the facade of such lives, we can see that they are not at all what they've been made to appear.Feb 3 2013: Yes! Rules are not always about rights and wrong, sometimes it's just about way of handling things or making a system.
No one can get a yes 100% of people on something, anything.
There will be always some people that even though they're right, disagree with other people that are right too.
Feb 3 2013: I think first you have to differentiate between rules and instructions. Rules are generally prohibitive and mandatory. Instructions, like the notes a musician plays or ways of conducting a project or system, are positive steps leading to a goal. Most of what Mr Schwartz and my question are regarding rules and laws.
I see your point about 100% agreement being impossible, but most disagreements are usually about different perspectives on a given subject. Those different perspectives normally result from incomplete view of the whole reality surrounding a subject. And those incomplete views normally result from active cherry-picking and ignorance born of a desire to skew reality or just from passive ignorance on the subject.
My thought was that if we moved away culturally from such directed ignorance, we could move closer to the ideal with the fewest rules possible. I really believe that if we valued finding truth over being right, we would eliminate the bulk of bias and there would be far fewer situations in which people were truly right but still disagreed.
Thanks for the thoughts.Feb 3 2013: No we wouldn't


text:
Remember when mobile phones were a futuristic, fictional idea? These days, our cellphones can do just about anything, but they're still a far cry from what visionaries dreamed they could be. From time travel to car control, some of the most amazing fictional phones pack features we can only dream of. But others are light years ahead of their time, predicting today's trends like wearable devices and phablets. Here are 10 of the most incredible fictional phones.
The term "bat phone" now refers to a private telephone line that deals specifically with urgent, high-priority calls. The saying was Inspired by the bright red phone in the Batman TV series from the 60's that connected Commissioner Gordon to the masked superhero. The phone, which glowed when it rang, also carried a tracking device that could be used in case of emergency.
is this bat phone for sale let me know


text:
With winter weather coming on, you may well be wondering where you can do your walking. A word to the wise: Westfield's Walking to Wellness is the way to go.
Sponsored by Bridgeport Hospital, Westfield Shoppingtown Trumbull, and Hudson United Bank, Westfield's Walking to Wellness is an organized mall-walking club. Membership benefits include free health and finance seminars every other month featuring Bridgeport Hospital and Hudson United Bank staff; quarterly breakfasts with fun free giveaways; and a walker's identification
We all know walking is wonderful for wellness. It's good for your heart, your bones, your mood—and, of course, your weight! At a brisk pace of four miles per hour, it takes 15 minutes to accomplish one mile. (Three times around the inside of the mall, hugging the outside wall, equals one mile.) In that time, you could burn off 70-80 calories or more,
depending on your weight.
Westfield Shoppingtown in Trumbull is open to walkers Monday-Saturday, 7-10 a.m., and Sunday 9-11 a.m. You can sign up for Westfield's Walking to Wellness at the Westfield Shoppingtown Trumbull Customer Service Booth any time during operating hours. Or you can sign up online! While you're on Bridgeport Hospital's website, check out the list of Special Events to find out about upcoming Westfield's Walking to Wellness seminars.
For more information, please call Jeanette Morgan, Marketing Coordinator, Westfield Shoppingtown Trumbull, at 203-372-4500.


text:
Complete an application for the Super Hunt drawing. Applications are available at license vendors, Fish and Game offices, by phone at 1-(800) 554-8685 or 1-(800) 824-3729, mail or online.
Voluntary donations are also accepted from hunters and anglers at all point of sale locations.
Property Contact:
Pleasant Valley Grazing Association
Directions: (North Section) From Rogerson, travel north on Highway 93 approximately 1 mile, then turn and travel east on Shoshone Basin Road (1600 N) approximately 4.5 miles.(Southwestern Section) From Rogerson, travel south on Highway 93 approximately 11 miles, then turn and travel east on dirt road near Rabbit Springs approximately 1.25 miles, then at "Y" take left fork (travel northeast) and travel approximately 0.5 miles, then at "Y" take right fork (travel southeast) and travel approximately 1.5 miles.
Description: Rangeland
Private Land: 10282 acres
Public Land: 15000 acres of BLM
Available: 7/1/2011 - 6/30/2014
Access: Unlimited
No vehicle use: foot or equestrian access only
No overnight camping
No open fires
* Follow links to view hunting opportunities on this property.No fishing opportunities available.


text:
Creston School District held its monthly school board meeting Monday, and discussion zeroed in on student assessment in academics, physical education and career technology.
Academic achievement
Creston School Board was presented with several graphs displaying the academic growth and decline in the areas of reading, math and science.
In the area of math, the No Child Left Behind Act set trajectories at the fourth, eighth, and 11th grade year starting in 2002. By 2014, the trajectories are expected to be at 100 percent proficient.
The next graph looked at math proficiencies for fourth-, eighth-, and eleventh-grade students starting in the 2008-09 school year for Iowa Test of Basic Skills, Iowa Test of Educational Development and Iowa Assessment. As of the 2012-13 school year, all grades improved in math. All grades have improved in math since last school year.
"It's going to take a herculean effort to keep it up there," said interim Superintendent Chuck Scott. "There isn't much room to move. Once you're at that high percentage, it will take a very concentrated effort all day, every day to sustain that."
In the area of reading, the No Child Left Behind reading trajectory graph is set for 100 percent proficiency by 2014. Sixth grade was the only grade to have a declining reading proficiency, dropping 7.3 percent. In the past five years, reading proficiency on Iowa assessment tests has been continually dropping; however, for all grades it has improved this school year.
In the area of science, there is no trajectory chart. Iowa assessment tests are above 80 percent for 2012-13 school year. This year, fifth-grade students' proficiency dropped .3 percent, and seventh-grade students' proficiency dropped 6.4 percent. Third grade proficiency increased almost 20 percent, on the other hand, and eight grade proficiency increased more than 20 percent.
Proficiency means the percentage of students that are at the 41st percentile and above.
Kevin Cooper, Creston Elementary School physical-education teacher, presented a video of elementary students in class to illustrate the physical education curriculum.
The video consisted of multiple sports such as wrestling, gymnastics and bowling. Each sport the kids participated in had rules. For example, in gymnastics there were mats on the floor for the kids to tumble on. A vault was built of mats, but the kids were not allowed to flip over the vault. There was also a station of adapted bowling for special needs children.
In the physical-education curriculum report concerning junior kindergarten through fifth grade P.E. benchmarks, all were 100 percent proficient except kindergarten at 99 percent. In grades six through eight, seventh grade had the lowest proficiency at 99 percent. In high school P.E. and health classes, the lowest was fitness with 99 percent proficiency.
The physical education report also had the fitness results for the national and presidential fitness tests.
The report said the data "gives us a really good snapshot of the overall fitness of our elementary P.E. students. ... Our students struggle in the area of endurance run, and our students also struggle with upper body strength when compared to other students their age."
The report also said the goal "is to focus on these areas more, continue reteaching and encouraging students to improve in these two areas."
Career technology
Creston High School industrial technology teacher Phil Wardenburg was also present.
Wardenburg discussed the career and technical education curriculum via a curriculum report based on a questionnaire given to the career and technical education instructors at Creston High School. The report included questions, answers from each area of education and course benchmark results from 2011-2012.
"Most of these benchmarks are probably state or national benchmarks that have been developed over time," said Wardenburg.
Of all the career and technical education benchmarks, two classes were not fully proficient. Business applications had 79 percent proficiency, and drafting had 78 percent proficiency.
"I know in some areas we're bringing more rigor and relevance," Wardenburg said. "You know, what is real out there in the world to these vocational areas?"
Wardenburg also said he tries incorporating core areas in his industrial technology classes, such as using science in welding and history in construction, so students maintain that core learning.
In other Creston School Board news:
• Cheryl Crall's seventh-grade students were present and gave the school board their opinions on using technology, like iPods and Kindles, in the classroom.
• The board did not recommend an increase in driver's education fees. The fees will remain the same: $350 for Creston students and $400 for out-of-district students.
• There will be a public meeting 9 a.m. Tuesday with Iowa Homeland Security to discuss possible places of improvement within the school district buildings.
• The board tabled the administrative team fringe benefits policy.
• "It was incredible how full our commons was," said Scott Driskell, dean of students at Creston Elementary School, of Family Literacy Night Jan. 22. The elementary school will host Family Math Night April 11 at 5:15 p.m.
• Creston School Board approved the new position of director of special populations.


text:
Disclaimer: If following this guide anything damages i shall not be held responsible.Do it at your own risk.
Step 1: Components
1- LM 386 semiconductor (IC)
2- 100 micro Farad capacitor
3- 220 micro Farad capacitor
4- 10 ohm resistor
5- 5 kilo ohm variable resistor
6- 100 ohm variable resistor
7- 0.01 capacitor
8- 0.047 capacitor
9- Wires
10- 9V Battery clip
11- 9V Battery
12- 3.5mm stereo jack male
13- 3.5mm stereo jack female
14- Project board (or you can use dotted board and solder)
You can find these electrical components from your nearest electronics store.These all components are easy to find and are common so you won`t have a hard time to find it.
also tell me how to know the variable ressistane which one is 5k ohm or 100ohm
hey if you are so much into making amps lets link up i have some diagrams of big amps
if i use a polarized capacitor on the place of 0.01 film capacitor will it work or not
hie i dont think it works
Works fine!!!
and 16 volts in 220 and 100 micro farad capacitors
try it, maybe its working
Can i make multiple outputs with this? Thanks!
Ok Guys can you guys help me out. I need sound amplifier for 12V Car battery. For two 250W speakers.
hey dude does it work on an empty PCB like this ? because i don't know how to make printed one
Hey... I like your design... I have 2 speakers 6 ohms each... can you explain your components and your design in detail to me..? I want to make it at home.
Thank you in advance.
Can I add a subwoofer to this.Please help me with the circut diagram.
Can I add a subwoofer to this.Please help me with the circut diagram.
I have also made but it's not working, please help me.
That is actually an advantage for when you're building high fidelity speakers; it is much easier to avoid interference if you amplify each speaker separately.
I wouldn't recommend attempting making a USB DAC, even the companies that sell them (iHome, Fiio, etc) buy them from someone else.
A small LED will work. WARNING LED MAY DAMAGE IF POLARITY (+/-) IS INCORRECT!!!
USB audio input may start to get complicated.I don't know if you may need drivers.
0.01 capacitor
and 0.047 capacitor. i want to know is this polysterfilm cap??? and what is the voltage rating of this cap?
i think you are referring to the ceramic cap which is look like a brown tablet
Hi, I made a simple 3 transistor amplifier and removed 2 resistors wich was causing alot of noise. Removing those 2 made the sound very clear out of the 8ohm 7w speaker. The problem I'm having is that the speaker isn't very loud. Transistors I'm using: BC337, BC547 and BC327. Anyone know how to make the sound louder?
make another stage to increase your gain, and try to use darlington transistor
but how can use variable resistor?
Can i use a pcb (printed circuit board) instead of a breadboard? And one more question, where did you get that LM386?
just hook up two audio jacks the one you need a 9v then a varible resistor done!
just hook up two audio jacks the one you need a 9v then a varible resistor done!
I enjoyed making this.
The pictures were a bit too dark and out of focus to be helpful, though.
hey the pictures are not too clear can help me with other pictures please!!
You can try with a small $2.50 microphone from Radioshack.
I would suggest using a 5v regulator. Make sure your polarity (+/-) is correct.
You may also want to replace your speakers as they are built for 12v-14v and this amplifier is 5v. If you follow the first two steps then you shouldn't damage anything however, I'm not responsible for any damage


text:
Dysfunctional Friends
Nine estranged friends are reunited after their larger then life friend unexpectedly dies. The friends who haven't seen each other in years are all forced to stay at their deceased friends estate for the weekend and must reconnect with each other working through all of their issues in order to each collect their inheritance.
Cast: Keith Robinson, Stacey Dash, Meagan Good, Wesley Jonathan, Datari Turner, Jason Weaver, Reagan Gomez-Preston, Terrell Owens, Stacy Dash, Stacey Keibler
Produced by:
Directed by: Corey Grant
Written by: Corey Grant
Running time: 1hr 51min
Opens: Feb 03, 2012 NY/LA
|Theaters for Today
Pick a day
on this day.


text:
Narrow Results By:
Finally, a bike you can ride in the house!
An exercise bike, also known as the stationary bike, is an excellent way to get a great cardio and lower body workout in. The stationary style allows you to work out in the comfort of your home, without taking up too much space. The variety of styles ranging from the upright bike to the recumbent bike and different settings allow you to choose your style of riding.
Experienced and/or amateur cyclists may take interest in some of our exercise bikes that incorporate innovative technologies that give you the feeling of actual road cycling, without the dangers of traffic and the risk of falling.
Call usChat Now
live chat


text:
I have a syncrowave 250 dx. I'm running on dc- every once in a while when I press the peddle to strike an arc my arm that is resting on my work bench will get shocked. It's extremely annoying and I can't figure out why it does this. It doesn't matter whether it's my torch arm or the other. And it's very random. I can't seem to find a pattern. Does anyone know what might be causing this?
Results 1 to 5 of 5
Thread: getting shocked
09-25-2013, 08:28 AM #1Junior Member
- Join Date
- Jan 2013
- Posts
- 19
getting shocked
I got popped a couple times the other day, not the first time by a long shot.
If things are damp, that seems to light me up. But the other day I just moved the ground right up next to the work and it didn't happen again.
Good gloves go a long way but won't always prevent it.
I did notice once that the arc was coming right out where the tungsten cap screws down onto the torch. The components seemed ok but that's where the arc would jump out.
good gloves, keep dry, keep a good ground close to work. If all that fails set some wood up to prop on.
09-25-2013, 10:38 AM #3Senior Member
- Join Date
- Oct 2009
- Posts
- 306
It's the high frequency on start up. Wear proper PPE (personal protective equipment) make sure you have a good ground and your equipment is in good repair.Miller syncrowave 200 runner with coolmate 4
and wp2025 weldcraft torch
Miller 125c plasma cutter
X2 on the high frequency. If you are sweating and gloves get damp it will get you every time. My hands sweat alot so i use seperate gloves for grinding handling etc and then a pair just for actual welding. If it bothers u that much and u are weldind steel u can turn the hf off and scratch start.
ask any TIG welder... getting zapped comes with the territory...
even more exciting during the sweaty summer months....
you might try and move your ground (work clamp) directly to your workpiece or as close as you can get it tho shorten the path... that might help some.(as said before)
you might do a search... there have been a lot of threads on it...
The more you know, The better you know, How little you know
The bitterness of poor quality remains long after the sweetness of low price is forgotten
Buy the best tools you can afford.. Learn to use them to the best of your ability.. and take care of them...
My Blue Stuff:
Dynasty 350DX Tigrunner
Dynasty 200DX
Millermatic 350P w/25ft Alumapro & 30A
Millermatic 200
TONS of Non-Blue Equip, plus CNC Mill, Lathes & a Plasmacam w/ PowerMax-1000


text:
Making Sense of Green Lumber
This article originally appeared in the March/April 2006 issue of Home Energy Magazine.
March 02, 2006
What does FSC certification mean for the future of sustainable lumber?
In recent months, I have been building decks in Northern California out of a Brazilian hardwood known as ipe. The client on one deck project was pleased with the tropical hardwood because of its beauty, and the project manager was happy that the use of this extremely dense hardwood increased the amount of time needed to finish the job (which translates to more money). Ipe is 3 times harder than oak, and is now used as a replacement for redwood, which most homeowners can no longer afford. Known as the poor man's teak, ipe is enjoying a new popularity in California.
To read complete online articles, you need to sign up for an Online Subscription.
Once an order has been placed there is an automatic $10 processing fee that will be deducted with any cancellation.
The Home Energy Online articles are for personal use only and may not be printed for distribution. For permission to reprint, please send an e-mail to firstname.lastname@example.com.


text:
With warmer weather on the horizon, Nashville music fans can look forward to the return of "Musicians Corner" in May. The free outdoor concert series kicks off its fourth year at Nashville's Centennial Park on Saturday, May 4, and will continue every Saturday afternoon through June 29.
The May 4 show will feature Nashville funk favorites The Dynamites featuring Charles Walker, soul/rock singer-songwriter Andrew Ripp and gospel institution The Fairfield Four, with Taylor Brashears, Levi Weaver and Pony Boy on a separate acoustic stage.
Future performers include Ben Sollee, Matt Wertz, Green River Ordinance, Ruby Amanfu, Street Corner Symphony, Brooke Waggoner, The Delta Saints and dozens more.
The festivities get underway at noon with a beer garden featuring local brews, food trucks and a kids' activity area - and the May 4 kickoff event will include a "Food Truck Fiesta" with 25 Nashville-area vendors. Musical performances follow from 2 to 5 p.m.
For more details and a full schedule, visit www.musicianscornernashville.com.


text:
Table Top Misting Fan - Angra Jr.
It's perfect by your pool, on your patio, in workshops or anyplace light cooling is desired.
This sleek contemporary looking Portable Misting Fan cools up to 400 sq. ft.
The 1 gallon reservoir is easy to fill and will last approximately 1 hour. The patented spinning disk in lieu of fan blades provides maximum cooling without high pressure, low volume pumps used in other systems.
Completely safe for environments where children might be curious how the fan works! The "ANGRA" is completely portable, weighs 18 pounds, uses about the same energy as a light bulb and has a low noise level of 60 db.
Dimensions: 17" L x 25" W x 11" H; 20 lbs.
Table Top Misting Fan - Angra Jr.
Shopping Cart