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Biologic therapies (biotherapy) focus on the body's biological response to the tumor. Most of these therapies take advantage of the body's immune system, either directly or indirectly, to fight cancer or to lessen the side effects that may be caused by some cancer treatments.
- How does the immune system work?
- How do biologic therapies work?
- What are biologic therapies used for?
- What are the major types of biologic therapies?
- What are the side effects?
How Does the Immune System Work?
In order for cancer to succeed, it must contend with the immune system. The immune system consists of a complex network of cells and organs that work together to defend the body against invaders, like bacteria and viruses.
The key cells involved in the immune system include:
Lymphocytes—This type of white blood cells are concentrated in areas of the body that commonly encounter hostile invaders (eg, gastrointestinal system, respiratory system, lyphatic system). Types of lymphocytes include:
- B cells—lead to the production of antibodies
- Cytotoxic T cells—directly attack infected or cancer cells
- Helper T cells—regulate the immune system's response by signaling other immune system cells
- Natural killer (NK) cells—produce powerful chemical substances that bind to and kill invaders
- Macrophages—a type of white blood
Cytokines—chemicals produced by both lymphocytes and monocytes; examples include:
- Interferons
- Interleukins
- Colony-stimulating factors
How Do Biologic Therapies Work?
Biologic therapies repair, stimulate, or enhance the body's response to cancer. According to the Leukemia and Lymphoma Society, biologic therapies:
- Eliminate, regulate, or suppress conditions that allow uncontrolled cell growth
- Enhance the immune system to fight the uncontrolled growth of cancer cells
- Make cancer cells more vulnerable to destruction by the immune system
- Change the growth patterns of cancer cells so that they are more like normal cells, and are less likely to metastasize (spread)
- Block or reverse the process that changes a normal or precancerous cell into a cancerous cell
- Enhance the body's ability to repair normal cells that get damaged by other forms of treatment for cancer (eg, chemotherapy , radiation therapy )
- Prevent a cancer cell from spreading to other parts of the body
What Are Biologic Therapies Used for?
Biologic therapies are most commonly used either to treat cancer that does not or has not responded to other forms of treatment or to try to treat tumors that may respond to the body's own immune defenses.
What Are the Major Types of Biologic Therapies?
The most common biologic therapies include:
- Interferons (IFN)
- Interleukins (IL)
- Colony-stimulating factors (CSF)
- Monoclonal antibodies (MOAB)
Interferon (IFN) occurs naturally in the body. IFN is produced by virally infected cells and is capable of protecting other cells from infection. There are three major types:
- Interferon alpha 2a (Roferon A)—used to treat hairy cell leukemia , Kaposi's sarcoma , chronic myelogenous leukemia (CML), and other conditions
- Interferon beta-1a ( Avonex , Rebif ) and interferon beta-1b (eg, Betaseron )—used to treat multiple sclerosis
- Interferon gamma-1b ( Actimmune )—used to treat chronic granulomatous disease and other conditions
Researchers have found that interferons enhance the immune system's ability to fight cancer cells and act directly on these cells by slowing growth and encouraging normal cell behavior.
Like interferons, interleukins (IL) occur naturally in the body and can be synthesized in a lab. Interleukins are named numerically: IL-1, IL-2, IL-3, up to IL-18.
IL-2 has been the most widely studied in cancer treatment. This type of interleukin stimulates the growth and activity of many cancer-killing immune cells, including NK cells and cytotoxic T cells. In addition, IL-2 enhances antibody responses.
Aldesleukin (Proleukin) is an IL-2 that is used to treat kidney cancer and melanoma .
Colony-stimulating factors (CSFs) do not affect cancer cells directly. Instead, CSFs help stimulate the production of new red blood cells, white blood cells, and platelets. This is important because many cancer treatments can decrease the levels of blood cells, which increases the risk of infection, anemia , and bleeding problems. Stimulating blood cell production can help stimulate the immune system.
Some examples of CSFs include:
- G-CSF (Neupogen) and GM-CSF (Leukine, Prokine)—increase the number of white blood cells, which reduces the risk of infection; also used to stimulate the production of stem cells in preparation for stem cell or bone marrow transplants
- Erythropoietin (Epogen, Procrit)—increase the number of red blood cells and reduce the need for red blood cell transfusion
- Oprelvekin (Neumega)—increase the number of platelets and reduce the need for platelet transfusions
Monoclonal antibodies (MOABs) are substances that are produced in a lab. The process involves injecting a mouse with cells for a certain type of human cancer. Once injected with the cancer cells, the mouse produces antibodies to fight against the cancer. These mouse antibodies are then combined with other lab cells to create hybrid cells to fight caner.
MOABs can be used in cancer treatment in a number of ways, for example:
- React with certain types of cancer, which may enhance the immune response
- Be programmed to act against specific cell growth factors to interfere with the growth of cancer cells
- Be linked to anticancer drugs, radioactive substances, other biologic therapies, or other toxins
- Possibly help destroy cancer cells in bone marrow (during the process of bone marrow transplant)
There are a number of MOABs available, such as:
- Rituximab (Rituxan)—used to treat non-Hodgkin's lymphoma
- Trastuzumab (Herceptin)—used to treat breast cancer when the tumor expresses excess amounts of a protein called HER-2
- Cetuximab (Erbitux)—used to treat cancers of the colon and rectum , as well as head and neck cancer
- Panitumumab (Vectibix)—used to treat colorectal cancer
- Bevacizumab (Avastin)—used to treat a certain type of brain tumor , kidney cancer , colon cancer, rectum cancer, lung cancer , and breast cancer
- Alemtuzumab (Campath)—used to treat chronic lymphocytic leukemia
- Ipilimumab (Yervoy)—used to treat melanoma
What Are the Side Effects?
The side effects depend on the type of biologic therapy that is used.
At the beginning of therapy, you will most likely experience flu-like symptoms. Examples include chills, headaches, muscle pain, joint pain, and discomfort.
Chronic side effects tend to increase in intensity after you have been on IFN therapy for several weeks. Loss of appetite with weight loss and fatigue can be severe enough to limit the dose. Other side effects include:
- Lack of energy
- Lack of concentration
- Decreased blood counts
- Protein in your urine
- Low blood pressure
Less common side effects:
- Nausea and vomiting
- Diarrhea
- Altered taste
- Depression
- Mood swings
- Decreased sex drive
- Memory problems
More common side effects include:
- Flu-like symptoms (eg, chills, fever, fatigue, headache, muscle pain, joint pain)
- Gastrointestinal effects (eg, nausea, vomiting, diarrhea, decreased appetite)
Other side effects include:
- Skin—redness, rash, dry skin, itchiness
- Heart and lungs—low blood pressure, rapid heart rate, arrhythmia , edema (fluid retention), weight gain
- Nervous system—confusion, disorientation, drowsiness, lethargy, anxiety , depression, irritability
- Decreased blood counts—anemia, thrombocytopenia, eosinophilia , lymphopenia
- Problems with kidney function
- Hypothyroidism
Severe toxicities are associated with high doses of IL-2.
CSF therapy is generally well tolerated. The side effects are minimal. Bone pain is one of the most commonly reported side effect.
With MOABs, allergic reaction to mouse protein is a major concern. The acute reaction can result in anaphylaxis , a severe, sometimes life-threatening, allergic reaction. This is rare, though.
More common side effects include:
- Fever
- Chills
- Sweating
- Discomfort
- Nausea and vomiting
- Itchiness
- Difficulty breathing
- Low blood pressure
A delayed toxicity that can occur is called serum sickness. Symptoms of serum sickness include:
- Hives
- Itchiness
- Joint pain
- Swollen glands
- Flu-like symptoms
Revision Information
- Reviewer: Mohei Abouzied, MD, FACP
- Review Date: 03/2015 -
- Update Date: 03/15/2015 -


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Action/Adventure, Suspense/Thriller
Jeremy Reins is about to have a very bad day. He wakes up in total darkness, confused and disoriented. The only light comes from the blood-red digital numbers ticking away above his head. Jeremy quickly realizes he's in trouble. It's hard to breathe. He can barely move. And no one will answer his cries for help. Then, he hears the sound of an engine and it all becomes clear...he's trapped in the trunk of a moving car.As his captors reveal themselves and their motives, Jeremy realizes he won't be set free until he gives up the whereabouts of "Roulette," a secret location where the U.S. President is taken in the event of a terrorist attack.
Cast: Stephen Dorff, JR Bourne, Tom Berenger, Bobby Tomberlin, Chyler Leigh
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Written by: Timothy Mannion
Running time: 1hr 32min
Opens: Mar 21, 2012 NY
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The Great Chaco Kids Giveaway!
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Nail art has become as ubiquitous of an accessory as a statement necklace or platform dazzler, which means you've gotta score a perfect 10 from your pinkies to your thumbs to get noticed. And just in time for Fashion Month, we've hunted down the polish princess of L.A., Madeline Poole, to give us some surprisingly easy tips on how to paint magnificent manis modeled after some of our favorite catwalk looks.
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Today's Track of the Day, off Alexkid's 2003 release Mint, brings a little bounce and a lot of feel-good to the table. Born in France and weened on the Parisian club scene, Alexkid began his diverse production career in 1999, with his debut single "Playground" put out by French House father figure Laurent Garnier. Between 2001 and 2006 Alexkid put out 3 wildly differing releases, Bienvenido, Mint and Caracol, on Garnier's F Communications label.
If you find yourself in Europe, try and catch one of Alexkid's sets at Berlin's Watergate nightclub, where he's the DJ in residence. If you dig this style, check out his label mates from F Commuications, Mr. Oizo and St. Germain, as well as Dominik Eulberg for deeper stuff and Ellen Allien for the electro kicks.


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Blindspot Cycles: Salvaged Motorcycles Reborn All-Electric
Blindspot Cycles hits two high points of green design with their line of reconditioned electric motorcycles. These discarded beauties are first found at junk yards and then converted with a rack of batteries, electric motors and controls. Think of it as Mad Max meets Tesla. I spent an afternoon at their shop talking with the owner Chris Ravana about not just bikes but how we can rethink sustainability from the ground up – read on for an exclusive report!
The principles that shape the construction of these bikes are straight forward: reuse it, keep it local, and make it work and look good. Reuse starts with a trip to a salvage yard looking for the right cycle. All makes and models have potential. They first help a client choose just the right ride. Now comes the fun part: stripping the unit down. They are looking to keep the bike's feel but replace the internal combustion engine with and electric powertrain.
These reclaimed motorcycles squeeze the past and future together. Coupled with a DND DC permanent magnet electric motor, a set of Deka brand AGM batteries and some styling you get a homebrew, super efficient ride. If they can find it salvaged rather than new it goes on. If it is high quality and American made then it goes in. As far as looking good we will let you, our dear reader, be the judge.
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[…] This E-Trike, which is a prototype, is charged from a 750-watt array of six solar panels that are on the roof of Hadar's studio. The chopper is 8.4 feet long and has a large 20-inch front wheel and 26-inch wheels at the back. Flat out, Hadar says that the bike is capable of 45mph. With even Orange County Choppers rolling out an electric motorcycle, we're excited to see trends shifting towards classic electric cycles. […]
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- Pengkun Yuan
- Nan Chang
- China
This conversation is closed.
Can social profiles get you hired or fired?
I'm going to attend a speech context next Thur., and the title of which goes like: From Campus To Career: Social Profiles Can Get You Hired or Fired. Frankly speaking I don't get it. Specifically, I don't undersand what does the phrase "social profiles" mean. Since I'm only a college freshman, this may be a little bit too far for me.
Nik Gill
Mar 24 2013: Hi PY!
- +2
I work at a global media agency & below are my thoughts on social profiles. Hopes this helps you on your project!
Getting Hired
Yes, social profiles are now very important to the hiring process (in most fields) as the information that you can glean from a social profile is richer than that of a Resume / CV
- For instance, a CV maybe built up of statements about you but within a social profile (e.g. LinkedIn) people can endorse your skills to back up what you have stated
- Also, potential recruiters can see who you are 'connected' to within your job sector, indicating how popular and experienced you are in your field instantly to them
Just through having a social profile you can see nearly everyone else's within the network. This is very useful when attending interviews as it allows you to research your interviewers and see if you have anything in common with regards to background or friends / colleagues. This can be invaluable when trying to strike a bond / begin a work relationship
Getting Fired
I work for GroupM, the largest Advertising Network in the world. We have a social code of conduct that explains that in the social realm, you cannot portray the company you work for in a bad light as it is detrimental to your employers
- Thus, if you have a bad day at work and moan about your boss and the company / state you're going to look for another job this could easily get you fired
We're currently interviewing and we will check both applicants professional profiles (LinkedIn) and personal profiles (Facebook) to see if they would be suitable / fit in at our company
- In saying that if we see something we don't like, they'll be 'fired' before they even get the chance to be 'hired'
Just to conclude, teachers tend to employ techniques to maintain personal social profiles, but keep them well 'hiidden' from their students, e.g. Sometimes they replace their last name with their middle name
Any questions, let me know!
Mar 25 2013: Very thoughtful and persuasive perspective. Thanks a lot!
Nik Gill
Mar 25 2013: Hi PK!
- 0
No worries. I work in the media industry so social media is something that we think a lot about.
Let me know if you have any questions and good luck with your project. Sounds like fun!
NikMar 21 2013: PY, I wiould not say that a social profile could get you hired ... but look at what could go wrong. Say you chat way to freely about a classified project ... or discuss the reason you were fired from your last job .... discuss the personal lives of other employees .... discuss your supervisors and bosses in negative manner .... discuss partying and personal encounters that show you in a bad light ..... There are plenty of other negative factors that we could both include that would not be complementary or seen as recommendations.
Many people are of the opinion that what they do on their own time is their business. Most companies have a morals clause. If your actions as a employee reflect poorly on the company then you will be dismissed. This will be a part of your contract and it will be enforced if you sign on with the company. Like it or not the government and most big firms have access to most of the information in our lives and "Big Brother" is watching.
There are a lot of people who want the job you are seeking. The company can put up a lot of filters. They have choices if you are seen as less than desirable you are eliminated from the selection pool.
Good luck. Bob.
Mar 21 2013: Thank you for your generous help, my understandings of this particular issue have become more and more profound and unique. You hit the point Robert, a person's overall social profiles can't reflect his/her working abilities, such as efficiency and accuracy, meanwhile, it is an important criterion concerning the person's morals and maybe loyalty to his/her company.
Anyway, this kind of issue varies from company to company.
Steve Lovig
Mar 19 2013: Mr. Yuan, first, don't discount yourself - being "only a college freshman" is actually an outstanding accomplishment. Many people WANT to be a 'college freshman,' but don't get the grades in high-school, or make the necessary effort. OK, with that said, your professor is most likely thinking of the social media sites like FaceBook, Linkedin, MySpace, twitter, Pinterest, etc. And the question beneath the topic title is most likely asking about positive or negative postings on "private" social sites and their interplay with business professionals looking to employ those individuals. Some college students post friendly pictures of weekend activities that may or may not sit well with prospective employers. And some employed individuals also post friendly pictures of weekend activities that may or may not sit well with their current employers. As an Adjunct Professor and an HR executive, I can tell you I've never fired someone for a social media site posting, but I have implemented punishment for some inappropriate comments made about the employer. I hope this comment is helpful; best of luck with your coursework. SL
- +1
Mar 20 2013: Thanks for your thorough perspective. Preparing for a speech contest can be really exhausting... I got the definition of the phrase ' Social Profiles' from gartner.com, and yes, you interpreted the phrase right! To my surprise, a lot of SOEs are now using this 'technique' as a way of recruitment.
Also, you've mentioned that you've never fired someone for a social media sit posting. And I guess you may work for a SOE or a multinational company. So, in your point of view, is it appropriate for companies to judge a person's overall abilities by their tweets, or simply by their bad pictures from Facebook. Frankly speaking, I seldom update my social profiles, It never occurred to me that these days, I'm forced to show some of my abilities on the internet, does this mean I'm kind of conservative?
Comment deleted
Mar 20 2013: Thank you for you information. Now I understand that a person's social profiles can really have huge impacts on his/her career.
Also, would it be convenient for you to share some of the experiences you or your friends have been through concerning this particular issue? For example, some companies that actually adopt a person's social profiles as one of the recruitment criteria. Maybe you can list the names of these companies.
ya chen
Mar 25 2013: haha, indeed, social networking is making this world small. I won't stay in Wuhan for too long as I'm having a test next Sat, what a pity! Here is my QQ number 836706857, and my Chinese name 陈雅,incase you'll need it when adding me, hehe. Looking forward to talk to you on QQ and definitely see you in Wuhan, good luck!
- 0
ya chen
Mar 24 2013: hi, I guess we are preparing for the same competition. Lucky to see you here. Have you finished your essay for the speech? Unfortunately I haven't yet... Good luck freshman!
- 0
Mar 24 2013: I can't believe it! Wow, world is small, isn't it?
We must meet and have some private comversations after we've been to Wuhan!
The good news is that I have finished the preparation for the speech yesterday. Now I'm still working on it...
How long do you plan to stay in Wuhan? I plan to go back to Nanchang next Fri.
I believe you can join me to explore more parts of Wuhan.
Can I have your QQ number?Mar 19 2013: Do you mean because of activity on social profiles?
Mar 20 2013: I got the definition of "Social Profiles" from gartner.com. Thanks anyway!


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20 November 2012On the evening of Thursday, 22nd November, Scottish Power is carrying out standard maintenance work to their Mound sub-station. During this period, the floodlighting at Edinburgh Castle and the lighting at the castle esplanade is expected to be switched off from 7:00 pm for approximately three hours. The work has been timed to minimise disruption to daily activity.
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Clever Hacks Give Google Glass Many Unintended Powers
Originally published on Wed July 17, 2013 8:55 pm
At Philz Coffee in Palo Alto, Calif., a kid who looks like he should still be in high school is sitting across from me. He's wearing Google Glass. As I stare into the device's cyborg eye, I'm waiting for its tiny screen to light up.
Then, I wait for a signal that Google Glass has recognized my face.
It isn't supposed to do that, but Stephen Balaban has hacked it.
"Essentially what I am building is an alternative operating system that runs on Glass but is not controlled by Google," he said.
Balaban wants to make it possible to do all sorts of things with Glass that Google's designers didn't have in mind.
One of the biggest fears about Google Glass is that the proliferation of these head-mounted computers equipped with intelligent cameras will fundamentally erode our privacy.
Google has tried to respond to these fears by designing Glass so it is obvious to the people around these devices when and how they are being used. For example, to take a picture with Google Glass, you need to issue a voice command or tap your temple before the screen lights up.
But hackers are proving it's possible to re-engineer Google Glass in any number of creative ways. And in the process, they've put Google in an awkward position. The company needs to embrace their creative talents if it hopes to build a software ecosystem around its new device that might one day attract millions of consumers. But at the same time, Google wants to try to rein in uses for Glass that could creep out the public or spook politicians who are already asking pointed questions about privacy.
So when Balaban first announced he had built an app that let folks use Glass for facial recognition, Google reacted harshly.
"I'd be lying if I said I was surprised," he said.
The company said it wouldn't support programs on Glass that made facial recognition possible — and changed its terms of service to ban them. But that hasn't stopped techies like Balaban from building these services anyway.
And now, there are all sorts of things developers are doing with Glass that were not built into the original design.
Michael DiGiovanni created Winky — a program that lets someone wearing Google Glass take a photo with a wink of an eye.
Marc Rogers, a principal security researcher at Lookout, realized he could hijack Glass if you could trick someone into taking a picture of a malicious QR code — a kind of square-shaped bar code that can send a computer directly to a website.
But today, Rogers has nothing but praise for how Google responded to his hack. He says less than two weeks after he disclosed the problem to Google, the company had fixed it.
"The other thing that is really good is the way they pushed Google Glass out to a community of people who are particularly good at finding vulnerabilities and improving software and fixing software — way before it is a consumer product," Rogers said. "This means that all of these vulnerabilities — or at least most of them — are going to be found long before Google Glass ever hits the market."
Google's decision to give the first few thousand pairs of Google Glass to tinkerers and hackers and geeks was intentional.
"In a case where you have [a product] that is so different from what is on the market currently, you really have to do these living laboratories where you figure out what the social and technical issues are before you release it more widely," said Thad Starner, a professor of computer science at Georgia Tech and a manager at Google Glass.
When Google released Glass to the public, it didn't sell it to just anyone. The first few thousand people who got a pair were developers, a technically sophisticated group whose first impulse was to take it apart, peer inside its code and understand how it works. These people are hackers at heart, and when they got their hands on Google Glass, they broke it on purpose, cracking it open and exploring all the ways it could be used or possibly abused.
"That's the great service our [Google Glass] explorers are doing for us," Starner said. "They are actually teaching us what these issues are and how we can address them."
But some of the issues raised by Google Glass might not be possible to address with a simple technical fix.
Ryan Calo, a law professor at the University of Washington who specializes in new technologies and privacy, has suggested that gadgets like Google Glass or civilian drones could act as "privacy catalysts" and spur conversations and legal debates about privacy in the digital age. Calo believes the conversations are long overdue.
From NPR News, this is ALL THINGS CONSIDERED. I'm Audie Cornish.
And I'm Melissa Block. Google Glass has generated lots of excitement, but also plenty of anxiety. It's a head-mounted computer equipped with a smart camera and the worry is it will erode our privacy. Google has responded by trying to make it obvious to people around these devices when they're being used. But as NPR's Steven Henn reports, hackers are reengineering Glass, passing some of that anxiety onto Google.
STEVEN HENN, BYLINE: So I'm sitting at Philz Coffee in Palo Alto, California, and this kid who looks like he should still be in high school is sitting across from me. He's wearing Google Glass and as I stare into the device's cyborg eye, I'm waiting for its tiny screen to light up. I'm waiting for a signal that Google Glass has recognized my face.
STEPHEN BALABAN: No matter what they say about the, you know, in the terms of service, you can run face recognition on this device. And it's been very difficult for Google to, I think, stop it, if people want to.
HENN: Google Glass isn't supposed to be able to do facial recognition but Stephen Balaban has hacked it.
BALABAN: Essentially what I am building is an alternative operating system that runs on Glass but is not controlled by Google.
HENN: Balaban wants to make it possible to do all sorts of things with Glass that Google's designers didn't have in mind. And he's one of a couple thousand coders and developers who got their hands on a pair of these high tech glasses this spring.
BALABAN: Google likes to think that they have control over how people use the technology that they create, but it's a Pandora's Box, right? Once you've opened it, it's very hard to say you have to use the technology in this very specific way.
HENN: Over the last few months, coders and hackers, like Balaban, has put Google in an awkward spot. The company needs to embrace their creative talents if it hopes to build a software ecosystem for Google Glass that's compelling and actually attractive to real customers. But at the same time, Google wants to try to reign in uses of Glass that could creep out or freak out the public.
So when Balaban first announced he had built a facial recognition app for Glass, Google quickly banned it.
BALABAN: I'd be lying if I said I didn't expect it.
HENN: The terms of service for Google Glass are much more restrictive than most other Google products. Still, developers are doing all sorts of things today with Glass that weren't built into the original design. Michael DiGiovanni created Winky, a program that lets someone wearing Google Glass take a photo with a wink of an eye. He says it's not for spying on people, really.
MICHAEL DIGIOVANNI: So I took a picture of a big sandwich that I had both hands on, hand a mouthful and I went to take a picture. A huge human need met. I mean, we've been waiting for how long to take the first person point of view shot of eating your own sandwich.
HENN: Marc Rogers is a principal security researcher at Lookout. He realized he could hijack Glass if he could trick someone into taking a picture of a malicious QR code. That's a kind of square-shaped bar code.
MARC ROGERS: The user wouldn't see anything at all. The user would take a photograph and then go on their merry way. Whereas what I would see is the user takes the photograph, the Glass would connect to my access point. My access point would tell me that they're connected and then it would give me some options as do I want to watch all their connections? Do I want to send an attack? Anything I wanted to do.
HENN: This hack would let Rogers turn on Google Glass' camera or send text messages or...
ROGERS: Read emails. You can put spyware on that will tell you what's going on. But the good thing is, that's not going to be the case because we found this vulnerability and fixed it.
HENN: Rogers disclosed the problem to Google and he says in less than two weeks, Google patched it. Today, Marc Rogers has nothing but praise for how Google responded to his hack.
THAD STARNER: That's the great service our explorers are doing for us.
HENN: Thad Starner is a professor of computer science at Georgia Tech and a manager at Google Glass. He says putting Google Glass into the hands of all these hackers and coders might look messy from the outside, but...
STARNER: They're actually teaching us what these issues are and how we can address them.
HENN: Starner's convinced, sharing Google Glass now with a wide variety of people should make the product safer and help Google understand how these wearable computers could ultimately fit into our world. Steven Henn, NPR News, Silicon Valley. Transcript provided by NPR, Copyright NPR.


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Louis J. DiIulio, age 84, of Sixth Avenue, Johnsonburg, died Wednesday, July 20, 2011 at Elk Regional Health Center of St. Marys after a lengthy illness.
He was born Dec. 12, 1926 in Keystone, son of Armundo and Viola (Cherry) DiIulio, both deceased. He married Carrie (Beer), she predeceased him in 1990.
He attended Johnsonburg schools and served in the Army during World War II in Company B, 864th Engineer Aviation Battalion. He received the Good Conduct Medal, Asiatic Pacific Theater Ribbon, WWII Victory Ribbon and Army Occupation Medal (Japan).
He retired from the Johnsonburg Paper Mill in 1988.
He was a member of Holy Rosary Catholic Church, enjoyed woodworking and lived all his life in Johnsonburg.
He is survived by one daughter, Sherry and her husband Greg Menniti of Proctorville, Ohio; three grandchildren, Adrienne and her husband Jeff Stallard, Scott Menniti and Tony Menniti; two brothers, Francis and his wife Pam DiIulio of Johnsonburg, and James and his wife Annie DiIulio. also of Johnsonburg; one sister-in-law, Delores DiIulio of Johnsonburg; and numerous nieces and nephews.
He was predeceased by his parents; wife; one brother, John DiIulio; and two sisters, Virginia Thompson and Mary Cartwright.
Visitation will be Thursday, July 21, 2011 from 2-4 p.m. and 6-8 p.m. at the Ubel Funeral Home, Johnsonburg, and Friday, July 22, 2011 from 8:30-9:30 a.m. at the Ubel Funeral Home, Johnsonburg.
There will be a Mass of Christian Burial at 10 a.m., Friday, July 22, 2011 at the Holy Rosary Catholic Church of Johnsonburg with Father David Wilson celebrant.
Military honors will be accorded by the Johnsonburg/Wilcox Servicemen's Detail. Servicemen are asked to assemble at the Funeral Home, Friday at 9 a.m.
Interment will be in Holy Rosary Catholic Cemetery, Johnsonburg.


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Some advice on software please...
Share your views on the state of the Animation Industry.
6 posts • Page 1 of 1
Some advice on software please...
I'm looking for some help folks. I'm an absolute beginner, no experience in animation at all - however I've been inspired to make a short film. I'm looking for a decent animation package for a beginner such as myself.
I have an idea of the features I'm looking for: The ability to scan/import images, photos and video (I'm no artist and won't be able to draw it all as I envisionage it) and to either trace these or convert them to animated frames. It would also need to be fairly simple to use and inexpensive. This is just a personal project and I'm conscious of not biting off more than I can chew so looking at a fairly static/ storyboard style with minimal/ choppy animation - the ability to create some depth would be handy too.
If anyone has any ideas and could point me in the right direction I would be most grateful...
Re: Some advice on software please...
I'm looking at Anime Studio 9 Debut currently - anybody got any experience with this? Just wondered if it's possible to use video in this and general thoughts on it's usefulness...
And if anybody can point me in the direction of a good animation overview/ tutorial etc...
Re: Some advice on software please...
There are many ways to go. You'll have to do research to find what's best for what you're looking to do.
Photoshop may work as it has an animation aspect to it. You might want to consider After Effects, or perhaps Flash, maybe even a video editing program such as iMovie or Final Cut Pro.
Animation specific software that you can check into includes Digicel Flipbook, CelAction 2D, and TVPaint. Toonboom is at the upper end of the spectrum for animation software. These are all programs for traditional animation and not CG.
As far as animation tutorials or overviews go I'm sure you can get something off of YouTube that will be of benefit.
Hope this helps and good luck!
Daily Z
Re: Some advice on software please...
Thanks for your input Charles,
So many options out there it difficult to know where to begin and how to distinguish between them!
Do you know off-hand if any of the software you mention can cope with importing video? I think I'm going to avoid movie software so I have a greater range of animation options. Perhaps.
Thanks again.
Re: Some advice on software please...
Hi Matt. I'm sure that's a feature with at least some of them. After Effects for example would certainly be able to do this. Take the time to research these programs and see what will work best for what you have in mind.
Daily Z
Re: Some advice on software please...
After Effects and Cinema 4D are definitely industry standards for Motion Design.
6 posts • Page 1 of 1


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Having lost power in Delhi and Rajasthan in the recently concluded assembly polls and having failed to topple the BJP governments in Madhya Pradesh and Chhattisgarh, the Congress is apparently headed for its lowest tally in the Lok Sabha polls in 2014.
Shekhawat is upset that 'non state' office-bearers who cannot win any election have assumed important positions at the expense of credible leaders who have been pushed into the background by Advani, writes Pankaj Vohra.
For the BJP, which essentially has strong roots in Delhi since its Jana Sangh days, a defeat would lead to its diminishing influence in the national capital, writes Pankaj Vohra.
The Delhi Police disowned one of its ace officers, Rajbir Singh, who brought so much of glory to the force. One fails to understand why he was not given a ceremonial farewell, writes Pankaj Vohra.
Instead of helping the Congress, the quota order will help some of its allies and opponents who are into caste-based politics, writes Pankaj Vohra.
There is obviously a section in the Congress that is either letting down the party president deliberately or is pursuing an agenda, writes Pankaj Vohra.
Sonia Gandhi must examine whether it would be worthwhile to restore the Congress Parliamentary Board, writes Pankaj Vohra.
The nuclear deal and the farm loan waiver would be the two main issues in the forthcoming general elections, writes Pankaj Vohra.
While everyone has hailed the Budget as good, one needs to examine whether the sops that have been offered will help the Congress reap political dividends in the elections, writes Pankaj Vohra.
Advani knows that the UPA's policies are alienating the common man, a mistake that even the NDA made. Pankaj Vohra examines...
Mumbaikars have to take the lead and tell the world that the parochial designs of a few will never be allowed to succeed. Pankaj Vohra examines...
This will be Advani's last shot at the office that has eluded him. But then he has to compete for the job with several others both within and outside the BJP, writes Pankaj Vohra.
So when the CPI(M) is unable to carry with it even those who are ideologically similar, then how will it go along with other parties which have their own regional agendas? Pankaj Vohra examines.
The much-awaited revamp of the Cong is running behind schedule and it has got delayed possibly because of Sonia's indisposition, writes Pankaj Vohra.
By proposing AB Vajpayee's name for the prestigious Bharat Ratna award, LK Advani has tried to politicise the annual national honours, writes Pankaj Vohra.


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Get your best pink outfits ready – the 2013 Komen Houston Race For the Cure will take place on Saturday, October 5th in downtown and registration is still available at www.komen-houston.org. If someone's look makes you blush or tickles you pink, post a pic with hastag #pinkoutday. Click through the slideshow for some of Houston's best […] [Read More]


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Title: Mars 2018 Sky Crane Capabilities Study
Primary Author: Bobby Braun
Institution: Georgia Tech
Date: March 1, 2010
Summary: The purpose of the Mars 2018 Sky Crane Capabilities Study was to "explore the full range of science capabilities that could be delivered to the surface of Mars in 2018 by an MSL-derived Sky Crane EDL system". NASA commissioned the Jet Propulsion Laboratory (JPL) to perform this study. The Planetary Science Decadal Survey Mars Panel was particularly interested in the following science pathways: a surface field geology/astrobiology pathway, a subsurface geology/astrobiology pathway and a network science pathway.
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The weekend rain was an added dose of aggravation for area farmers already delayed in their spring planting.
Late last week, Iowa State University Extension field agronomist Aaron Saeugling said field conditions were still soggy for many farmers trying to get in the fields after the heavy downpours of late May.
"Some soils in Union County need a week of dry weather, because it's plenty moist now," Saeugling said.
That didn't happen, as showers rolled in again Saturday night. Through Sunday evening, Creston received .57 of an inch of weekend rainfall.
Just more aggravation for farmers in what has been a record-setting wet spring (see related story).
Soybean planting has been delayed by nearly 50 percent and some producers still haven't quite finished corn planting. For that crop, time is of the essence.
Bill Northey, Iowa's secretary of agriculture, says some farmers face tough decisions because of the wet weather.
Decision time
Northey said June 10 (today) is a "sort of cut-off date" for planting corn in Iowa, while farmers can plant soybeans as late as the first week of July.
But, a shortened growing season means a shorter crop. Field specialists are suggesting narrower rows and increased population in soybean planting to maximize canopy and growth.
According to Iowa State University Extension and Outreach research, soybean yields decline by an average of .25 to .9 bushels per day when seed isn't in the ground by May 15. There is a 50 percent chance of frost in this area by Oct. 8-10.
According to Iowa Farm Bureau, planting progress is slower than it was in the dramatic flood year of 1993.
When last week began, Iowa farmers had planted 88 percent of the corn crop, up just 3 percentage points in a week, according to the U.S. Department of Agriculture. Usually, 99 percent would be in the ground.
Forty-four percent of the soybean crop was planted on June 2, down from the usual 91 percent. Just 23 percent had emerged, which is the lowest since 1996.
"We've had five full days and three half days of field work since May 1," said Matt Brown, who farms in eastern Union County.
Still, Brown said he has about 85 percent of his corn planted and 90 percent of his planned soybean acreage done.
"I'm counting myself pretty lucky," Brown said. "We moved pretty quick in those three or four days of good weather. I stayed on the planter for 39 consecutive hours."
Insurance mark
The crop insurance late planting period for corn began on June 1.
"Corn can still be planted after this date, but the insurance guarantee on those acres is reduced by 1 percent per day until the acres are planted," said Kelvin Leibold, ISU Extension farm management specialist.
Corn acres planted after June 25 will receive insurance coverage equal to 60 percent of their original guarantee. The late planting period for soybeans is June 16 through July 10.
Acres that have been planted, but need to be replanted, may qualify for a special replanting insurance payment. These payments are based on the value of eight bushels of corn or three bushels of soybeans per acre times their respective projected prices, or about $45 per acre for corn and $38 per acre for soybeans.
"There are some isolated cases of replanting going on in Union County, but not huge," said Saeugling. "Actually, Adams and Taylor counties seemed to bear the brunt of the real large rainfall, from what I have observed.
"In all honesty, it's too late for corn now," Saeugling added. "Most are abandoning corn (planting) at this point, and I would encourage producers to look at other crops, such as soybeans, unless you have no other options because of feed needs or your herbicide and fertilizer choices."
Faster hybrids
Saeugling also suggested moving to earlier maturity variety for corn that is planted this late. That could reduce yield by anywhere from 25 to 50 percent, but full-season corn is running into a timeline where there would be concerns of frost damage at the end of the season.
Tracy Camron, agronomist for Gavilon Grain of Creston, said emergence is another problem.
"Some crops have been in the ground for two weeks and not showing up very good yet," Cameron said. "We had a lot of cool, cloudy weather. We're in the process of examining for remedial action, such as replanting those spots."
Some of the heavy downpours of late May occurred on already moist soil. Soil particles "crusted," Saeugling said, and the corn didn't have the ability to push through that crust.
"The cool temperatures compounded that," Saeugling said.
Brown said he had some emergence problems in no-till fields where soybeans had been planted.
"Anything we planed between May 20 and May 24, in the no-till, it has not come out of the ground at all," Brown said. "It got cold and wet and the plants just shriveled up and died."
Farmers also need extended dry weather for their hay crop, a situation worsened by the weekend rain.
Hopeful forecast
Still, today's varieties are resilient, shown by the substantial yields by many farmers last year during drought conditions. Crops could recover and still produce well if warmth and rain come at the right times throughout the summer.
Warmer temperatures, with highs in the 80s, are forecast this week. But, farmers are casting a wary eye at forecasts calling for possible showers to occur more than once in the seven-day forecast.
"At the end of this year you'll probably see what amounts to an average over a two-year period," Saeugling said. "But that doesn't help the guys trying to get in the field right now."
Brown is crossing his fingers for another window of field-work weather this week.
"It looks like there's a chance for Tuesday through Friday to be dry," Brown said. "We're hoping we can finish up by the end of the week. Last year was an unlimited window. This year, it's been challenging."


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- Brendon Butler
- Dunedin
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Founder & Director, 2Day Mine Soutions - Think Tank
This conversation is closed.
If you have a physical solution to the global economic & human development situation. Who would the best global leader to go to for help?
At the base of our economy is a sector. A primary sector that is absorbing 4 times as much of the global economic value added process as it should if it were to be corrected. Reforming this particular primary creates a flow on benefit that flows throughout the rest of the economic pyramid. Creating added value at every step. Because this is a "Global Primary Sector" the primary sector in question has been secure in the fact that there is currently no Government, NGO or international governing body with the influence or ability to fix it. So if the physical solution is true, who or what will take the lead on reforming a global primary sector? A genuine question to TED enthusiasts, especially if all the reform information is ready to be implemented with in weeks. The Oblivious Mining Industry Cartel. http://www.scribd.com/doc/109637671/Interference-Anomalies-in-Global-Mining Video: http://youtu.be/7lxbM20AKM4
Mar 1 2013: Don't worry about implementation I have got that covered.
A consultancy wont even get close to it it will be taken up by a global leader that wants to do good, or something like that.
Popular movement will drive the rest.
Do you think that all the manufacturers will allow the miners to take more of a cut than they should?
Manufacturers will force the change beause manufacturers have a US$trillion they "need' to invest.
It is a slam dunk.Feb 26 2013: Modelling is not done on something no one has a model of yet. does that make sense?
You know what it is called though?
Unity, Global Unity...
Unpredictably powerful to those on the outside.
Supremely predictable to those on the inside.
I don't really need a leader as such. More a leading platform!
Do you understand that I am actually the leader I require? I just need my platform.
The data is and will always be in progress as this has never happened before.
http://www.scribd.com/doc/109637671/Interference-Anomalies-in-Global-MiningFeb 26 2013: Here is a video that will put this into perspective. http://youtu.be/7lxbM20AKM4
Feb 26 2013: Wow Brendan - that's radical .. I like it!
Where's the data?
Also - have you done any modelling on the method?
Right now I am going to vote for attilla the hun or Ghengis Khan - not because they will do anything directly positive, but because they will more quickly collapse the system that permitted the likes of them to exist in the first place.
Direct oposition seems to only prolong the agony and reduce our options after the end-game.
Feb 26 2013: 15 minutes ago: Modelling is not done on something no one has a model of yet. does that make sense?
You know what it is called though?
Unity, Global Unity...
Unpredictably powerful to those on the outside.
Supremely predictable to those on the inside.
I don't really need a leader as such. More a leading platform!
Do you understand that I am actually the leader I require? I just need my platform.
The data is and will always be in progress as this has never happened before.
Or you could simply ask the CEO's of the companies I have divulged. Like I have already done.
This is way beyond go Mitch!
Feb 27 2013: OK - I'll check the link now.
Cool yes.
It has been long understood how much gold lies in the ground. It is kept there very intentionally. I think it's probably the best indicator to your arguement - base metals are what drives not just ecoomic growth, but technological growth (.. I add the caveat that if you have gold, there is no constraint to technology - but there is a great constraint to the access to it if you have no gold).
The Citigroup brochure tells it all. There is no market any more outside of the plutocracy - if you do not sell to this market ... you are screwed.
That's because of the rate of gold extraction - nothing more.
Makes me larf when people harpo on about returning to the "gold standard". There is so much of it we could eat it. That, plus the understanding that not all oil is biological ..
But there are limits. The extraction rates of these things have system impacts. And as usual, the costs of that are being arranged to fall on those who have no gold.
All indications are that the plutocracy is poised to remove all access to gold (including fiat currency) from all but those who control it. This is a selective part of the current mass extinction - the line will be drawn when the human driven extinction reaches .. just before .. the no-return threshold (those who know . . know .. and that line will nto be stepped accross. It will be a sudden hitting of the wall for most humans. And let's face it - they are not required anymore. I say "they" but there is no guarantee that I will get through - so I might be part of "they". hey ho.
I was once a committed part of "us" and just watched on as "they" all fried their brains out with mobile phones and continued to eat more and more cummulative toxins (you have to add "Monsanto" to your list I think.
The platform is currency. Everything you say can be modelled quite easily - and probably has been long ago.
look at what currency is: curent value = investment - consumption . gold was never neededFeb 27 2013: Time is the only scale-able commodity.Feb 27 2013: Einstein might disagree on time.
This is unchartered water.
The models are about I am sure.
However, you are missing that this is all metals all at once. Gold currency, metal technology, economic growth, investment confidence, cash velocity, Government involvement etc…
This is unprecedented especially when tied into the economic spaghetti mix.
I do not believe the current models apply in this scenario.
I would challenge any economist to predict the right outcome.
If you follow my LinkedIn profile, you will see the many chief economists and economic professors that are keeping an eye on my work.
The people on top may see this as an opportunity or equally as a threat or even a mixed bag.
The outlook is incredibly complex.
Feb 28 2013: I'll model it in NetLogo.
This is something I've been wanting to do for a while.
With your permission I can constrain a prime resource and call it "metals".
I have to warn you that these models are non-linear - and fixed-point attractors are rare.
Just at the onset - my belief is that agriculture lies at a more fundamental position - it is something that seems to have been precipitated at the end of the Younger Dryas.
The model will build some varients with and without markets, with and without currency.
I was prompted to get on with this model to examine currency - but I expect plutocratic monopoly to emerge with certain dynamics imbedded in the abstraction of currency.
I will also add adiction to the parrameter set.
It is started, but will take a while as I get control of the modelling tool.Feb 28 2013: OK, About 1/4 through your paper.
Here's some things that might help - I have a comprehensive map of logistics as a global entity - it sits between supply and demand (including market nodes - retail).
The map is in 3 levels - strategic, tactical, operational this identifies the functional processes at each level with another dimension covering funding and another showing accounting. Happy to share the map if you like.
Here's some things to consider:
1. The human brain is divided into 3 functional nodes - proto, core and autobiographical. THis is far more significant than even neuro-scientists understand - particularly when one explores what teh autobiographical is and what it is for. It is cogent to the systemic anomaly which you identify.
2. Looks at De Bono's analysis of serial development - it helps.
I can't find the little youtube vid - but it's just about trying to construct a square out of shapes as they "turn-up" .. it all works fine, you can get clever and make squares by adding the shapes using inovatiive methods, but then a shape comes along that will not fit no matter what you do - it then becomes necessary to dismantle the entire structure before the new piece can be added - this is the principle of vested interest.
This phenomenon is exactly the same as the "local minimum" in the science of self-organising systems. Well worth researching.
In the usual order of things, local minima represent the truth within a specific perceptional span - it works so long as the span is wide enough, but if reality requires a widening of that span, the local minimum will begin to deliver error. This error will accumulate until the minimum is ruptured and the system seeks the lower minimum.
Depending on the "potentiation" which holds the local minimum together, the resulting "noise" of error will have a specific threshold before rupture. That threshold can be very high indeed.Feb 28 2013: Practical questions:
Does slow explosive produce dust?
What is the average face-advance per cycle with 1. fast explosives, 2. slow explosives?
Next - what is the stability impact between slow and fast explosives? (roof stability/bolt/mesh requirement - assuming inclusion of fault frequency)
I can see a 1 hour cycle achievable using slow explosive - critical cost/benefit being face advance rate. Techniques might also include continuous face-advance if the face was widened and sectored .. which would be an advantage in vein tracking.Mar 1 2013: OK Finished reading your paper.
It's a reasonable BPR analysis. But it will be ignored if it is not presented by a major consultancy - as such, it will have a $1mill entry cost, plus a business case proposal which will fail to demonstrate ROI due to risk/opportunity analysis.
The miners will have contingent liabilities associated with supply relationship costs. These contingencies will not be discussed outside of the boardroom.
It is part of how corporate culture forms-up.
I have seen this process in a few industries - not just mining. I call it "the destruction of value for profit".
It is difficult to grapple with this sytemic problem, but, as far as my analysis went, the primary parameters of destruction-of-value-for-profit are:
1. Reverse supply dynamic permited by the use of currency .. the market force of demand is inverted when the goods are replaced by the currency - and the supply becomes currency.
2. Money is time - time is not money.
3. Organisations are designed to fail - the corporate mission is subverted by the parts of teh corporation = a large company contains many empires that are at war with each other. The only rule in a corporation is "don't get caught". This induces some incredibly inovative game-play that causes more "churn" in fund-flows than you could ever imagine. Most corporations consume around 90% of investment funds in these games.
4. No corporation can allow the line-workers or line-managers to contribute to business process. Doing so has a few downsides - a) it can lead to single-point dependency, b) it can lead to stagnation, c) it erodes hierachial authority - and responsibility which might lead to wage scale-flattening. So some of these are valid, but obviously, some are downright invalid in the light of ROI for investors - if they knew what was being done. So the role of strategic BPR is delivered to consultancies - and the imense cost of consultancies is deliver one commodity: credibility. It is knowledge-laundering.Mar 1 2013: The interference patterns you observe are the result of the size of the companies involved.
It is also affected by the amount of funds moving through the company.
The empire phenomenon is incredibly powerful - it increses the vested-interest factor by orders of magnitude.
The ultimate result manifests as reduced adaptivity.
This stagnation will persist until the emperors extract themselves from teh host - it is only after a safe distance has been established for the "players" that the company will be allowed to collapse - and, in fact, the collapse of the company on late movers is a part of the game which delights the emperors greatly.
AS you have shown - the devil is in the detail. No one gets enough time to actually discern the detail from outside the company. There is no conspiracy - it is just the dynamics of teh system.Mar 1 2013: Don't worry about implementation I have got that covered.
A consultancy wont even get close to it it will be taken up by a global leader that wants to do good, or something like that.
Popular movement will drive the rest.
Do you think that all the manufacturers will allow the miners to take more of a cut than they should?
Manufacturers will force the change beause manufacturers have a US$trillion they "need' to invest.
It is a slam dunk.
Simplicity in global arguements wins everytime. The market is going to force it!
Mar 1 2013: You have demonstrated quite well how the BPR of mining operation can have very large global impact on global GDP. I could demonstrate similar items in retail, logistics, insurance, banking and telecommunications. As a BPR analyst in all these sectors, I have identified at least one interference point in each - some as large as the one you identify, some less - but all of which could be described as "evil" in the minds of most people.
Can I ask you this:
If you were to get the opportunity of leading a change - what would be the evidence of your success?Mar 1 2013: Haha. Yes very good.
Evidence. Wait and see is all I can say.
I am planning 50+ years of evidence of success.
The problem will be stopping.
You should keep in touch. find my LinkedIn.
Mar 1 2013: HI Brendan,
Go for it!
I'll stay in touch, but not through social media - there are undercurrents in them that I wish to avoid.
I'll send my details through the TED contact.
Many thanks for the opportunity to engage in this discourse - it's given me a few new angles on the models I want to get done.
I get the gist of where you are headed, hope my input has had a value towards that.
Gail .
Feb 25 2013: There is no one who has not already sold you out for money and power who is in a position to do what you would like. But loving money and power, they are not willing to give up all in order to show that it can be done.
- 0
Your underlying concern is one that is increasingly shared by all of humanity.Feb 25 2013: don't follow leaders, watch your parking metawsFeb 24 2013: Diogenes was sure a character indeed. Although his methods may have been different with a laptop and connectivity.
My position is unique.
The changes I have proscribed are already taking affect with in the mining industry. So I may be in danger from an unseen force. But I do not think that this will happen.
Because the Mining sector is actually completely unaware that this manipulation force has been at play.
Now here is the interesting part.
The 3 companies that have allowed this manipulation to take place are completely unaware themselves that this is what they have done. It is actually a surprise to them as much as it is to you or I. Now that is a unique global position!! Even if they wanted to stop it they have no idea how. And to prove it the company CEO and President of one of the 3 companies that have set this scene is now connected with me on LinkedIn. If you want a game changer. This is it Robert. You are not going to get any better, anywhere.
It is already too late for any vested interest to stop. And to be honest I could not think of one game enough to try.
And why would they want to stop it? It actually increase the wealth and wellbeing for everyone on the planet.
I don't think you would find a force powerful enough to stop this global goodwill.
Again, this is happening now. But to get the very best out if it I need a Leader with a global backbone and a big chin.
Keep thinking keep thinking. There has to be someone....Feb 24 2013: Check with Diogenes. As far as I know he never found the honest man. Remember absolute power corrupts and power corrupts absolutely.
Those in power or of great influence would never allow this to occur. It would deminish their grasp on power and wealth.
Good luck. Bob.Feb 24 2013: the very basis of the argument is wrong here. our society is not like a pyramid, with the economy as the base. much like a cart of welfare and hybris, pulled by the horse of the economy. you don't need to fix the horse. if you want more speed, make the cart lighter. optimally, get rid of the cart altogether. we are the horse. we don't need the cart.Feb 24 2013: Yes. Thank you for your Question Fritzie.
All metal mining taking place on the earth today is included in the change I have. It is actually a good question you ask. I did not say it was the mining sector because in the past people have thought that mining related organisations should only be responsible. The eyes of the intellectual level of people I require have unfortunately glazed over when I mention the word mining.
Where in this case it is of absolute important not to include any mining institutions but only use people of Practical International Political Economics understanding.
If you read the first 7 pages of my publication (Link below) you will understand clearly the difficult task ahead for me.
Because the flow on changes are far bigger to the rest of the economy than the actual changes to mining. It is of the highest importance a global, environmental, humanitarian, social, long-term, and economic view be included in any decision making.
Current NGO, Government Organisations and Global Governing bodies seem not to have the mandate to cover all tasks. Therefore, I am certain a new committee needs to be set up to split up the tasks into forms that the current organisations can handle.
The problem I have is I cannot yet find a change leader willing to understand or take on this task I and we require.
Is there anyone you or other TED members can think of that would be interested in such a global task?
There are leaders on the side-lines waiting to see who takes the first step. This is no good to me. I need one that takes that has the fortitude to take the first step in a global economic overhaul.
Anyone have any leadership suggestions?
BrendonFeb 24 2013: Is there some reason you don't want to specify here which sector you are talking about even as you ask where to go to try to achieve reforms in it?
Is your argument that mining is the fundamental sector at the base of the economy and asking where to go to seek reforms in mining?
I am guessing this from your profile.


text: Desktop Virtualization Latest News Benefits Project Plan Events FAQs Project Plan Our project plan is continuously being updated. Please check back often for more detailed updates. Phase I (November 2011 - January 2012) Phase I of the project is complete. We were able to implement 268 virtual desktops in these areas: Management Information Systems / Computer Science Courses in these programs are using Virtual Desktops and it has been successful. Check out some of the testimonials on this site to see what professors and students have to say. Coyne Science Center Addition The computing facilities located in the new Science Center Addition are the first academic spaces on campus to benefit from Virtual Desktop technology. We introduced Thin Clients in these labs, one of the many devices that can run virtual desktops. Every classroom in the new building is equipped with a thin client in the teaching station as well. This allows the professors teaching in these classrooms to take advantage of the benefits of virtual desktops. Phase II (March 2012 - August 2012) Our goal during this phase is to deploy 200 virtual desktops. Academic Computing Labs In this phase we would like to introduce virtual desktops in some of our currently existing computing facilities. Department Discussions This will be a combination of faculty and staff that have been identified as benefiting the most from moving to desktop virtualization. We would like the community to participate in various discussions about which areas this applies to. Phase III (September 2012 - February 2013) Our goal during this phase is to deploy 200 virtual desktops. Ongoing Department Discussions We will continue to identify the areas that benefit from this technology the most and develop a schedule to move the rest of the campus to virtual desktops. Phase IV (March 2013 - August 2013) Our goal during this phase is to deploy 200 virtual desktops. Phase V (September 2013 - February 2014) Our goal during this phase is to deploy 300 virtual desktops.


text:
Kosher Bread
|My New Favorite Traditional Challah
Adapted from Rose Levy Beranbaum
When packing for a business trip I love to start a large bread for my husband to eat while I'm away. Challah is one of his favorites and since it's one of mine as well, I usually manage to eat a few slices myself before slicing, wrapping and freezing the rest. It is traditional for Jewish New Year's to shape the challah in rounds. It is easiest to start by making a 3 braid challah and then coil it around itself and tuck the end underneath.
1/2 cup water
Special Equipment: An insulated baking sheet or two baking sheets, one on-top of the other, lined with parchment. A baking stone or baking sheet
Set aside 1 1/2 tablespoons of the eggs for the glaze.
Mix the dough: In a medium bowl, whisk together the flour and yeast; then the salt.
In the mixer bowl, place the water, eggs, honey, corn oil and vinegar. Add the flour and with the dough hook, mix on low until moistened. On medium (#4 Kitchen Aid) beat for about 5 minutes or until the dough is smooth and shiny. Add flour if necessary until it almost clears the bowl The dough should be just barely tacky. (The dough should weigh about 30.2 ounces / 856 grams.) Form the dough into a ball.
Let the dough rise: Place the dough into a 2 quart dough rising container or bowl, greased lightly with cooking spray or oil. Push down the dough and lightly spray or oil the top of the dough. Cover the container with a lid, plastic wrap or a damp towel. With a piece of tape mark on the side of the container approximately where double the height would be. Allow the dough to rise, ideally at 75 to 80 °F., until it has doubled, 1 1/2 to 2 hours (to 2 quarts). Gently deflate the dough by pushing it down, give it 2 business letter turns and allow to rise a second time. (The second rising takes about 45 minutes to an hour.
Flatten the dough gently by pressing down on it, so as not to activate the gluten, making it stretchy. If desired, for best flavor development, the dough now can be placed in a larger container or wrapped loosely with plastic wrap, placed in a 1 gallon plastic bag, and refrigerated overnight -- in which case give it a turn or two first. Allow it to sit a room temperature for 20 minutes after dividing in 4 pieces and preshaping into logs.
Don't allow too much bulge in the middle, i.e. braid tightly so that it doesn't spread when rising and baking. Push the ends together a little so that the loaf is about 14 inches long by 4 inches wide by 2 1/2 inches high. Place the loaf on the prepared baking sheet. Brush with glaze and cover. Let rise to 15 x 5 x 3 1/4 inches highabout 1 hour.
Preheat the oven: 45 minutes before baking preheat the oven to 325°F. Have the oven shelf at the lowest level and place a baking stone or baking sheet on it before preheating.
Glaze and bake the challah. Remove the plastic wrap and brush the challah all over with the egg glaze, going well into the crevices of the braid. Sprinkle the top with poppy seeds if desired, tilting the pan slightly to have access to the sides.
Cool the challah on a rack.
Yield: Makes: A 16 inch by 6 inch by 4 inch high, 4 braid loaf
* It is traditional for Jewish New Year's to shape the challah in rounds. It is easiest to start by making a 3 braid challah and then coil it around itself and tuck the end underneath.
KosherEye Note: Rose also bakes this recipe using a starter. For the recipe, click here.
Recipes: Bread, Challah, Yeast, Parve, Kosher


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|Assistant Coach - Defensive Line
|Previous College:
|Liberty '03
Aaron DeBerry enters his first season as a member of the Missouri Southern football coaching staff. He will be responsible for coaching the defensive linemen.
DeBerry comes to Southern after two seasons at Independence Community College where he served as the defensive coordinator and coached the defensive line. Under his tuteledge, more than 15 of his players signed four-year scholarship offers to continue their playing careers.
He previously spent six seasons as a coach on the high school level. DeBerry kicked off his football coaching career in 2006-09 serving as the co-defensive coordinator and defensive line coach at Indian River High School in Chesapeake, Va. While at Indian River, DeBerry guided the school to two playoff berths, one resulting in a state semifinals run. In his four seasons at IRHS, DeBerry helped produce seven All-District candidates, three All-Tidewater selections and one All-State nominee.
During the 2010 and 2011 seasons, DeBerry served as the defensive coordinator and defensive line coach at Creekside High School in Fairburn, Ga. During those two seasons, he would assist CHS to one playoff appearance while also producing eight All-Region nominees, three All-State selections and one Under Armor and Army All-American candidate.
DeBerry attended Liberty University from 1999-2003 where he would be a four-year starter. He played under ICC head coach Steve Carson, who was defensive coordinator, during his senior season in 2003. He holds three current school records at Liberty, including career sacks (26), most sacks in a game (4) and career tackles for loss (44).
He finished his playing career in the Canadian Football League with the British Columbia Lions in 2004. DeBerry was married on June 21, 2014 to the former Yashica Hampton.


text:
Katie Rickels Biography
Katie Rickels
Graduate Intern of Fitness & Wellness
2011-2014 B.S. Kinesiology with a concentration in Fitness Leadership, University of Alabama at Birmingham
2015-2017 M.A. Exercise Physiology, University of Alabama at Birmingham
Professional Experience
2013-2014 Fitness Instructor, Gardendale Civic Center
2013-Present Fitness Instructor, Global Fitness & Tanning Warrior, AL
2014 YMCA Health Coach and Personal Trainer, Birmingham, AL
2014 Fitness Attendant, UAB Campus Recreation
2014 Fitness and Wellness Undergraduate Internm UAB Campus Recreation
2014-Present Fitness Instructor, UAB Campus Recreation
2015-Present Graduate Intern of Fitness & Wellness UAB Campus Recreation
I was born and raised in the small town of Morris, Alabama. I love Birmingham and everything about living in the south. I enjoy running, teaching fitness classes, baking, and painting. My nickname is sunshine because you will always find me with a smile on my face!
Favorite Quote - "If it's not challenging, it's not changing."
Contact Information
Email - email@example.com
Office: Graduate Office


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Addison boy is golf prodigy at 2-years-old
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An apartment fire broke out overnight in Fresno on September 1. When firefighters arrived at 2:30AM, they saw a home filled with smoke and flames. The family living inside was able to escape, and their apartment was the only one destroyed. At the time of this recording, investigators are still trying to figure out what sparked the fire. With the serious stuff is out of the way, let's talk about the star of this story and your new favorite person: Next-door neighbor Robert Wright. He and those ribs of his were on the scene and KMPH Fox 26 News was there to interview him. Wright explained, "It all went down man, I stayed right next door, man, from the thing that happened, man, a barbecue, man. I was barbecuing, man. I seen some fire just come out the window, man, the window busted out, man. The only thing I think first is make sure them ribs is right." Wright continued, "I got my kids first, first thing I got my kids and I thought about my ribs, I didn't want to let my ribs to burn and stuff because I take pride in what I do, man. It's like 3 o'clock in the morning, I was hungry, man. I was like, 'Man, put them ribs on there, man. Some hot links and stuff, man.' We got it going and stuff, but I looked over, the fire was bursting. I was like, 'Man, this is crazy, man.'" So, man, he get any injuries? Nope, man. "I got no injuries, except for all the smoke in my lungs, but I already had smoke in my lungs, so I'm alright," Wright mused.
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