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Not a lot happens on �Togetherness.� In the first episode, we meet Brett (Mark Duplass) and Michelle (Melanie Lynskey), a married couple living in Los Angeles with their two children. By the end of the first episode Brett�s best friend Alex (Steve Zissis) and Michelle�s older sister Tina (Amanda Peet) move in with them. In terms of plot, that�s pretty much it. Alex is a struggling actor who has been evicted from his apartment. Tina is a needy, emotional train wreck who is visiting from...
There needs to be an official Minnesota mid-January holiday to celebrate the fact we've made it through the first half of January.
Ralph Pabst of rural Sanborn once planted 11,000 trees over a long weekend; all it took was a year and a half of planning, a bit of financial help from the Department of Agriculture, and a healthy dose of elbow grease donated by his family....
The intersection of Bridge Street, Highway 101, and Union Drive presents a challenge: any work to be done on it will have to go through three levels of government — city, county, and state.
This list of superfood staples will rev up your diet and have your body feeling better and stronger.
A lighter take on a comforting classic.
So long, boring salads!
Your sleeping position not only reveals a lot about your personality�it may also affect your health and quality of sleep.
Netflix was the big winner at Sunday's Screen Actors Guild Awards, winning its first three awards,...
Last season, Orphan Black sent in the male clones, and when the sci-fi drama returns for its third...
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Explore the undergrowth and discover a colourful world of adorable bugs and pretty flowers with this fun collection of sewn gifts. Whether it's a beautiful butterfly mobile for a new arrival, a cute snail toy for a little boy or a handy ladybug bag for a little girl, there's something here to delight kids of all ages. There's also a fantastic applique quilt that's sure to become a treasured family heirloom.
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Has anyone ever modifyed or re-built the steering linkage and rear axle on one of the Lowes garden cart?
Results 1 to 10 of 11
Thread: Lowes Garden Cart
06-21-2010, 10:32 AM #1Senior Member
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- So. Cal
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Lowes Garden CartFab Tech
06-21-2010, 01:26 PM #2Senior Member
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- Abilene, Texas
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41 views and no replies. I don't guess that anyone has. What do you plan on doing to the cart?Jim
06-21-2010, 07:06 PM #3Senior Member
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Well 106 views and still nothing. It might be a tough project I got myself into
I'll see what I can do
Hope this project is not too big for meFab Tech
If you are talking about the Ackermann theory. The inside tire has a smaller radius.
I hope I spelled his name right.
Thanks, PTsideshow I knew I butchered his name.Millermatic 252 w/30A
Big Blue Air Pak
Ellis 3000 Band Saw
Trailblazer 302 Air Pak w/ Wireless Remote
Dynasty 200 DX
XMT 350 MPa w/S-74 MPa Plus
Millermatic 211
Passport Plus
Spectrum 625 X-TREME
Lincoln SA-200 Blue Tint Red Face '63
2-Lincoln SA-200 Red Face '68
SA-200 Black Face '59
SA-200 Green Lite '84
SA-200 Green Lite '80
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'70 Black Face Round Barrel
06-22-2010, 05:19 AM #5Senior Member
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I guess you're talking about a four wheel steer wagon.
I've built one for my mig when I wanted to run it over gravel. All I did was make an angle iron frame for the the bed. Then I made two pivoting axles, think of two front ends on a wagon. On one I attached the tongue. Then I attached a rod diagonally between the front and rear axles.
The great thing about four wheel steer is you don't have to allow for tail swing or tail cut when making a corner. Properly made your wagon's rear wheel will follow in the exact path of the front one when making a turn.
The downside of the one I built is when making a sharp turn the wagon can tip over if top heavy. But it was simple and easy to make so I did it that way knowing I had issues with tip over under some circumstances.
Now if you're handy and can make your axles with king pins and tie rods, as on a go kart, golf cart, automobile, you can have a four wheel steer wagon that trails tricker'n than anything without the tip over issues.
Don't know If you are talking about one of these
Tractor supply garden dump cart, was thinking of what can be done for other uses with the style of frame steering. I have no use for an off road/gravel welding cart. But it could work if the center of gravity is lowered.
All the bits and pieces laid out, I did a review of that style for another site. the steering part is upper right side in this photo the draw bar is attached by pivot to the center of the control arm to each wheel. As this cart can be used to tow behind a lawn/garden tractor. The handle can be turned around for a hitch pins trailer hitch
This is the front section of the frame,Steering assembly before being attached
If you are looking for what the steering looks like I can go out and snap a few pic's but right now it is filled with Fruit wood being transferred form its former home to its new short life as fuel for the son's smoker
This is the small version carries less than the 1,000 pound version, the garden flat top carts at the garden centers around here all have the same type of steering set up.
Originally Posted by Bob Miller
Here is the google link there are a number of illustrations that are available
glen, If your not on the edge, your wasting space
06-22-2010, 08:23 AM #7Member
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I love these posts/subjects that challenge all your engineering and welding skills. If I recall, thinking back to my erector set days, screw 'A' goes into slot 'J' and tighten gently. Don't overtighten this bolt as it will have to be removed and another support placed on the screw at a later time.
Be sure to have sufficient air in your tires. Never leave your wagon behind your father's car. (...how many times have I told you to put your toys away when your done with them.)
06-22-2010, 04:02 PM #9Senior Member
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My neighbor wanted to use mine but I said No________way. He bought the yellow one Friday; he was moving block Saturday for his wall and the front wheel hub blew out and the whole thing collapsed, way too funny, he threw a tantrum. So I thought about beefing up mine befor it happens to me .
http://www.lowes.com/SearchCatalogDi...=garden+cart+#Fab Tech
I've got a different version of that same cart bought about7 years ago.......I don't think realistically you should have a problem with it.......I was using it haul logs from a gigantic tree we cut downmore than a 1000lbs at a time......thank god for ratchet straps.....and using my rider to haul it around.........never a problem with it........still have it lengthened to 8 foot long now.its my party tent permanent hauler......definitely one of the better purchases I've made.JimWelding in Crete
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Some really cool hammers BIG and small


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The EMX D-TEK MVP is a standard vehicle loop detector that can be used in any 11 pin harness or socket. The great feature about the D-TEK MVP is that can be used with any voltage from 9 to 220, eliminating the need to stock multiple loop detectors based application this one unit can do them all. The unit also offers the ability to work in both fail safe or fail secure mode based on your application needs.


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Comet Halley
Date: 14 Mar 1986
In 1986, the European spacecraft Giotto became one of the first spacecraft ever to encounter and photograph the nucleus of a comet, passing and imaging Halley's nucleus as it receded from the sun. Data from Giotto's camera were used to generate this enhanced image of the potato shaped nucleus that measures roughly 15 km across. Some surface features on the dark
Every 76 years Comet Halley returns to the inner solar system and each time the nucleus sheds about a 6-m deep layer of its ice and rock into space. This debris shed from Halley's nucleus eventually disperses into an orbiting trail responsible for the Orionids meteor shower, in October of every year, and the Eta Aquarids meteor shower every May.
"Going back further in time, ESA's Giotto mission to comet 1P/Halley was a milestone, showing for the first time that comets have nuclei. This was the first time a spacecraft came close enough to look through the fog surrounding a comet. Hard to believe that was only in 1986."
--Peter Jenniskens: Research Scientist, SETI Institute and NASA Ames Research Center
(Read More of what Peter Jenniskens has to say about this and other significant events by clicking here.)
"Data from Giotto's camera, which used an automated targeting system, included a spectacular image of the potato shaped nucleus that measures roughly 15 km across. What surprised everyone was that the nucleus was not a snow-white ice ball, but dark as a lump of coal. Some craggy surface features and craters could be seen, and jets of gas and dust streaming into Halley's coma. This was the first-ever image of a "primitive body," and a highly active one at that. The automated targeting device was even fooled, homing in on a jet coming off the dark surface as the spacecraft flew past (rather than the surface itself, which was expected to be bright). Data obtained on the composition of single comet grains discovered something new -- grains of pure organic material or "CHON" -- and nothing else, proving that comets are largely organic material rather than snowballs!"
--Jeff Cuzzi: Research Scientist, NASA Ames Research Center
(Read More of what Jeff Cuzzi has to say about this and other significant events by clicking here.)
Credit: Halley Multicolor Camera Team, Giotto Project, ESA


text:
Welcome to Hyperion Records, an independent British classical label devoted to presenting high-quality recordings of music of all styles and from all periods from the twelfth century to the twenty-first.
Hyperion offers both CDs, and downloads in a number of formats. The site is also available in several languages.
Please use the dropdown buttons to set your preferred options, or use the checkbox to accept the defaults.
'Simplicity is everything. After having exhausted all the difficulties, after having played immense quantities of notes and more notes, then simplicity emerges with all its charm, like art's final seal. Whoever wants to obtain this immediately will never achieve it: you can't begin with the end. One has to have studied a lot, even tremendously, to reach this goal; it is no easy matter.'
from notes by Angela Hewitt © 2004
extrait des notes rédigées par Angela Hewitt © 2004
Français: Hypérion
"Schlichtheit ist alles. Nachdem man alle Möglichkeiten durchgespielt hat, eine riesige Zahl von Tönen und noch mehr Tönen gespielt hat, dann erscheint die Schlichtheit mit ihrem ganzen Charme, wie der letzte Siegel der Kunst. Wer sie sofort beherrschen will, wird es niemals schaffen; man kann nicht mit dem Schluss beginnen. Man muss sehr viel, gar enorm, studiert haben, um bei diesem Ziel ankommen zu können; es ist keine leichte Angelegenheit."
aus dem Begleittext von Angela Hewitt © 2004
Deutsch: Viola Scheffel
|Chopin: Nocturnes & Impromptus
'In a catalogue boasting many distinguished Chopin Nocturne cycles, Angela Hewitt's commands attention' (BBC Music Magazine)
'One of the most elegant pianists around, the Canadian virtuoso Angela Hewitt interrupts her epic Bach and Couperin cycles for Hyperion to explore som ...» More
|Chopin: Preludes & Impromptus
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Renowned pianist Artur Pizarro releases his third disc for Linn Records which follows on from the success of his two Beethoven Sonatas discs and his recordings of Chopin piano music.» More
|Chopin: The Complete Works
Since his triumph as winner of the 1970 Chopin International Piano Competition, Garrick Ohlsson has established himself worldwide as a musician of magisterial interpretive and technical prowess. This monumental recording project—first instigated by t ...» More
|Eileen Joyce – The complete Parlophone & Columbia solo recordings
'Listening to Joyce is strangely addictive. One cannot wait, as it were, to read the next chapter. She shares with Kreisler and Tauber the same unteac ...
'The quality that comes across in these performances is the sheer joy of playing. Joyce possessed a formidable technique and an interpretative mind th ...» More
|Grigory Ginzburg – His early recordings – 2
'Grigory Ginzburg (1904-61) was a 'quiet pianist' who none the less offers a 'masterclass in keyboard mastery'. This, finely put, offers a clue toward ...
'Ginzburg has been well served over the years … a harmonious look at his early studio recordings and they are complementary and indispensable it ...» More
|Harold Bauer – The complete recordings
Gramophone» More
|Moura Lympany – The HMV Recordings, 1947-1952
Moura Lympany (1916-2005) was the last of the major Matthay pupils and she started working with him in 1937 when he was already 79. In 1938 she shot to international fame when she came second to Emil Gilels in the Queen Elisabeth competition. A br ...» More
|The Piano G & Ts, Vol. 4 – Diémer, Eibenschütz, Hofmann & Backhaus
|Vassily Sapellnikoff & Xaver Scharwenka – The complete recordings
Vassily Sapellnikoff (1868–1941) and Xaver Scharwenka (1850–1924) were among the earliest generation of pianists to record, and on this ground alone it is surprising that their complete recordings have never before been transferred for modern list ...» More
|Chopin: Nocturnes & Impromptus


text:
Hang tight!
Recipe by MakeItHealthy
"I love this recipe. I could eat at least ten in one sitting which is why I exchanged some butter with non-fat plain yogurt. They still taste great and I feel a lot better about eating so many."
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2 3/4 cups
all-purpose flour
1 teaspoon
baking soda
1/2 teaspoon
baking powder
1/2 cup
butter, softened
1/4 cup
nonfat plain yogurt
1 1/2 cups
white sugar
1 teaspoon
vanilla extract
Delicious! They turned out beautifully! They were fluffy and light and you couldn't tell they were "healthier" =D
The flavor and taste were pretty good; there's no reminder that they're "low-fat" as I eat them--however, the texture was like that of a small biscuit rather than a cookie. I'm thinking that this is due to the baking soda that was added in the recipe. Next time, I'll omit the baking soda and add a little more baking powder instead. Kind of a disappointment.
33 Ratings
This is a very simple sugar cookie recipe. I used slightly less sugar as someone else suggested - maybe an 1/8 cup less. The texture is great and it is a soft cookie. I had no problems rolling the dough into a ball. I put sprinkles on the cookies too. My husband loved them and they will be in his lunch bag tomorrow.
The recipe worked well. No problems with rolling or dryness. I made a couple of changes: added the 1/4 of yogurt, but mine was fat free, Greek style, vanilla flavored; also omitted 1/2 cup of sugar as another reviewer suggested; encrusted in rainbow sprinkles (made them sweet but not TOO sweet - please see pix); added 1tsp almond extract instead of vanilla. This helped with that blandness someone else mentioned. I liked them very much and would definitely recommend this recipe. Oh, and also added pink food coloring to make them a little more festive for my 4 year old. If anyone would like to add food coloring to their dough, please add to the wet mixture and then add the flour.
They came out delicious. I did have a slight hiccup with the batter though; it came out really gooey, and thus hard to ball up. It may have been due to the lack of butter. I might suggest adding another tablespoon or two of butter, OR going with a greek yogurt that contains a little fat (I used 0%).
Turned out great. I will use 1 cup of sugar next time...a bit sweet for me personally, but a GREAT cookie. Still nice n soft and it's 4 days later!!
Great recipe. Very soft and tasty, and great with milk or coffee. I omitted the vanilla, used only 1 cup of sugar, substituted low-fat vanilla yogurt instead of the non-fat, and used whole-wheat flour. The batter was a tad dry, so I added 2 tablespoons more of yogurt.
Used whole-wheat flour, 1/2 c. packed brown sugar, 1/2 c. white sugar. Instead of vanilla, substituted 1 T. matcha (green tea) powder mixed in 1 t. water and beat into egg before adding to butter mixture. Dipped tops of cookies into black sesame seeds before baking. Would add green food coloring next time because cookies were brown, but delicious!
* Percent Daily Values are based on a 2,000 calorie diet.
Healthier Easy Sugar Cookies
Serving Size: 1/48 of a recipe
Servings Per Recipe: 48
Amount Per Serving
Calories: 70
Calories from Fat: 19
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These sugar cookies stay puffy and moist even when cool.


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text:
The hallowed turf at Twickenham has changed a lot since
its humble beginnings. Since the early 1900s the turf has transformed from
an actual cabbage patch to 'The Cabbage Patch', home of the English national
team and the home of Rugby. It has been the site of some truly spectacular
matches including, but definitely not limited to, Australia's controversial
narrow win over England in the 1999 World Cup, and an amazing run of 19
unbeaten home games for England beginning in late 1999 lasting a period
of five years culminating in an Irish victory in 2004.
This amazing, rare, historic print, published in the UK
by the London Transport Museum, features a reprint of a vintage 1921 poster
promoting travel to the Patch by Underground and Tram on the London transit
system. With amazing action artwork from a glorious era in the history
of the game, it evokes thoughts of piling into the grandstand on a chilly
Saturday afternoon and enduring friendly banter between opposing fans,
all while feeling the anticipation for the match build within to a fever
Celebrate Twickenham and the beautiful game in
style with this glorious print perfect for the wall of any fan!
Product Specifications:


text:
With his DeMatha Catholic High School football team clinging to a single-score lead and trying to stop a fourth-and-goal from the 5-yard line, Cameron Phillips intercepted a pass and stayed focused on the green turf ahead of him.
He raced past the crowd of Our Lady of Good Counsel players in his immediate vicinity.
He raced past the speedier would-be tacklers chasing frantically.
He raced past future Virginia Tech teammate Kendall Fuller, the Good Counsel alumnus who watched from mere feet away on his alma mater's sideline.
"I was just looking for the end zone," Phillips said.
Ultimately, Phillips' 96-yard third-quarter pick-six left DeMatha's recent Good Counsel woes in the dust.
DeMatha beat Good Counsel, 21-0, Friday to end a four-game losing streak in the rivalry, the most recent setback coming in the last season's Washington Catholic Athletic Conference championship game.
"It was something that needed to be done," DeMatha coach Brooks said. "We don't like to say that there are must-win games, but for us, it was a must-win game."
Good Counsel has won the last four WCAC titles, wrestling away the conference's crown from DeMatha, which had won six straight league titles prior. Though DeMatha didn't end Good Counsel's WCAC winning streak — Gonzaga snapped it last week at 22 games — the victory made an emphatic point.
"We want to take the WCAC back where it belongs, which is DeMatha Football," DeMatha linebacker JaWhaun Bentley said. "We definitely like playing our type of football. We don't want to adjust to Gonzaga, all those teams, Good Counsel, teams like that. We just want to come out and play our ball."
Bentley said DeMatha Football is defined by being "hard-nosed," and it definitely was Friday night. But this game was also defined by DeMatha's big plays, Phillips' and one each by Wisconsin recruits Taiwan Deal and Chris Jones.
Deal ran 95 yards for the final touchdown, scoring on DeMatha's first play of the fourth quarter. Jones caught a 75-yard pass to set up DeMatha's first-quarter touchdown, a 9-yard pass from John Lovett to Lorenzo Harrison.
Making the win sweeter was that no DeMatha player was on the team in 2010, when DeMatha last beat Good Counsel.
In 2011, Brooks used a sophomore-heavy lineup with an eye toward this season. In 2012, DeMatha showed significant progress by reaching the WCAC title game, but at that time, Brooks said a championship was the goal.
Brooks reiterated that goal Friday, but all the players appreciated overcoming the bugaboo in front of them.
"Talking about it for four years — 'Good Counsel is so great, Good Counsel this and that,'" Deal said, "Coming out and beating them 21-0 is a huge accomplishment for the 2014 class and the whole DeMatha community."
The potential DeMatha community was on hand Friday, too.
Brooks "rolled the dice" and invited several youth teams to watch the game from the DeMatha sideline at the Prince George's Sports & Learning Complex.
"People want to see DeMatha-Good Counsel, and many of these guys, they'll be considering both programs," Brooks said. "So, we wanted to bring them out and show them that we have a pretty good program."
With both teams attempting to remain among the WCAC elite for the considerable future, Good Counsel must address its immediate outlook after falling to 0-2 in the conference and 3-3 overall.
"They won't quit," Good Counsel coach Bob Milloy said of his players. "They'll keep trying. We're just going to try to get healthy by the end of the year and hopefully get in those playoffs and see if we can have a crack at a couple of these teams."
Before the season, Brooks said Good Counsel was the league favorite "until someone proves that they can knock them off." Friday, Brooks wouldn't declare DeMatha (5-1 overall, 2-0 WCAC) the new favorite, citing Gonzaga, Bishop McNamara, Bishop O'Connell and St. John's in what might be a wide-open WCAC.
But that doesn't diminish this step of the process.
"Good Counsel has been the gauge for so long," Brooks said, "So to finally get over that hump and get back to playing DeMatha football felt good."
DeMatha 21, Good Counsel 0
Good Counsel (3-3) 0 0 0 0 — 0
DeMatha (5-1) 7 0 7 7 — 21
D — Lorenzo Harrison 9 pass from John Lovett (Mac Burke kick)
D — Cameron Phillips 96 interception return (Mac Burke kick)
D — Taiwan Deal 95 run (Mac Burke kick)
DeMatha — Taiwan Deal 12-129, Mark Allen 9-32, Lorenzo Harrison 4-12, Cameron Phillips 1-4, Chris Jones 1-0, John Lovett 5-(-7).
Good Counsel — Perry Stefanelli, Chris Dawson 10-35, Andres Castillo 2-10, C.J. Carroll 2-8, Bryan Strittmatter 1-4.
DeMatha — John Lovett 8-17-140-0
Good Counsel — Andres Castillo 4-20-32-1, Bryan Strittmatter 2-4-21-0.
DeMatha — Chris Jones 3-85, Cameron Phillips 2-26, Greyson Torain 2-20, Lorenzo Harrison 1-9.
Good Counsel — Keon Paye 3-20, Chris Dawson 1-16, Myles Robinson 1-11, 16 C.J. Carroll 1-6.


text:
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD
Name: Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD. ..more
Related BioAssays
Related BioAssays
Tested Compounds:
Related Experiments
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC)
Affiliation: The Scripps Research Institute, TSRI
Assay Provider: Gerald R. Smith, Fred Hutchinson Cancer Research Center
Network: Molecular Library Probe Production Centers Network (MLPCN)
Grant Proposal Number: GM031693
Grant Proposal PI: Gerald R. Smith
External Assay ID: RECBCD_INH_ABS_1536_3XIC50 DCSRUN + phage
Name: Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD.
Helicobacter pylori infects approximately half of the world's population and is responsible for inducing chronic gastric inflammation that can progress to gastric cancer (1). At the cellular level, Helicobacter pylori infection of the human stomach is associated with inflammation that elicits DNA damage in both bacterial and host cells (2). This DNA damage must be repaired in order for the bacteria to persist. The H. pylori AddAB helicase-exonuclease is required for DNA repair and efficient stomach colonization (3), and inhibitors of this enzyme may be useful antibacterial drugs for treating these infections. The AddAB class of enzymes is closely related to the RecBCD class of helicase-nucleases; both classes are widely distributed in bacteria but appear to be absent in eukaryotes (4). The protein complex functions in DNA repair by directing free DNA ends into the homologous recombination pathway (5). As a result, the identification of inhibitors of AddAB may be useful tools for elucidating the role of AddAB and RecBCD in bacterial recombination and as potential novel antibiotics with few off-target effects.
1. Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest. 2007 Jan;117(1):60-9.
2. Ernst P. Aliment Pharmacol Ther. 1999 Mar;13 Suppl 1:13-8. Review article: the role of inflammation in the pathogenesis of gastric cancer.
3. Dillingham MS, Kowalczykowski SC. RecBCD enzyme and the repair of double-stranded DNA breaks.
Microbiol Mol Biol Rev. 2008 Dec;72(4):642-71.
4. Amundsen SK, Fero J, Hansen LM, Cromie GA, Solnick JV, Smith GR, Salama NR, Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.. Mol Microbiol, 2008. 69(4): p. 994-1007.
5. Chedin F. and Kowalczykowski S.C. A novel family of regulated helicases/nucleases from Gram-positive bacteria: insights into the initiation of DNA recombination, Mol. Microbiol. 43 (2002), pp. 823-834.
helicase, nuclease, exonuclease, AddAB, ADDAB, AddAB complex, RecBCD enzyme, beta subunit, gamma chain, alpha chain, Escherichia coli, E. coli, bacteria, phage, DNA, dsDNA, DNA damage, DNA repair, DNA binding, ATP-binding, homologous recombination, recombination, Chi, inhibition, inhibitor, optical density, OD, absorbance, exonuclease V, helicase, nuclease, RecBCD, RecBCD complex, recB, recC, recD, beta subunit, gamma chain, alpha chain, HTS, high throughput screen, counterscreen, dose response, triplicate, viability, cytotoxicity, secondary, 1536, Scripps Florida, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN.
Assay Overview:
The purpose of this assay is to determine the efficacy of compounds in RecBCD dose response assays for those that confirmed activity in a set of previous experiments entitled, "Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex" (AID 488942), and were active in a set of experiments entitled, "Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD" (AID 488955) and inactive in a set of experiments entitled, "Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of bacterial viability" (AID 488956). Compounds that also inhibit E. coli RecBCD may be useful as an early indication of compounds that may have potential to elicit a broad-spectrum antibiotic like effect.
This assay involves infecting E. coli with a T4 bacteriophage that carries three nonsense mutations in gene 2, whose wild-type protein product protects viral DNA from RecBCD-mediated degradation after infection. The mutant T4 phage is able to infect and block the growth of V67 E. coli (recB21, a recBCD null mutation), which lack RecBCD nuclease activity. The mutant phage also infects V66 E. coli (recBCD+), but V66 proliferate because of the RecBCD helicase and nuclease activity against the unprotected mutant phage. In this assay, the V66 E.coli cells are infected with mutant T4 phage in the presence of test compounds, followed by measurement of well optical density as an indicator of bacterial growth. As designed, compounds that inhibit RecBCD will allow the virus to replicate and block bacterial growth, leading to reduced well absorbance. Compounds are tested in triplicate in a 10-point 1:3 dilution series starting at a nominal test concentration of 118.6 uM.
Protocol Summary:
Prior to the start of the assay, V66 and V67 bacterial cultures were grown at 37 C until it reached an OD600 of 0.05 or 2.5e07 cfu/mL. To start the assay, 3 uL of Assay Buffer (0.1% Glycerol + Cation Mueller Hinton Broth) was dispensed into all wells. Next, 60 nL of test compound in DMSO, Ciprofloxacin (0.95 ug/ml final concentration) or DMSO alone (1.2% final concentration) were added to the appropriate wells. Then, 1 uL of V66 (recBCD+) or V67 (phage control) bacterial cultures were dispensed into the appropriate wells and plates were incubated for 60 minutes at 37 C.
Next, 1 uL of mutant T4 2 149 bacteriophage was dispensed to the appropriate wells at a multiplicity of infection (MOI) of 0.02. Plates were centrifuged and after 18 hours of incubation at 37 C, absorbance (OD600) was read on a Envision microplate reader (PerkinElmer, Turku, Finland) using 10 flashes per well.
The percent inhibition for each compound was calculated as follows:
% Inhibition = 100 * ( ( Test_Compound - Median_Low_Control ) / ( Median_High_Control - Median_Low_Control ) )
High_Control is defined as wells containing V66 + Ciprofloxacin + phage
Low_Control is defined as wells containing V66 + DMSO + phage.
Test_Compound is defined as wells containing V66 in the presence of test compound + phage.
For each test compound, percent inhibition was plotted against compound concentration. A four parameter equation describing a sigmoidal dose-response curve was then fitted with adjustable baseline using Assay Explorer software (Symyx Technologies Inc). The reported IC50 values were generated from fitted curves by solving for the X-intercept value at the 50% inhibition level of the Y-intercept value. In cases where the highest concentration tested (i.e. 118.6 uM) did not result in greater than 50% inhibition, the IC50 was determined manually as greater than 118.6 uM.
PubChem Activity Outcome and Score:
Compounds with an IC50 greater than 10 uM were considered inactive. Compounds with an IC50 equal to or less than 10 uM were considered active.
Any compound with a percent activity value < 50% at all test concentrations was assigned an activity score of zero. Any compound with a percent activity value >= 50% at any test concentration was assigned an activity score greater than zero. Activity score was then ranked by the potency, with the most potent compounds assigned the highest activity scores.
The PubChem Activity Score range for inactive compounds is 100-0. There are no active compounds.
List of Reagents:
V66 (recBCD+) and V67 (recB21) E. coli bacteria (supplied by Assay Provider)
T4 2 149 mutant bacteriophage (supplied by Assay Provider)
Ciprofloxacin (Sigma, part 17850)
Cation-Adjusted Mueller Hinton II Broth (BD, part 297963)
1536-well plates (Aurora, part 19326)
Due to the increasing size of the MLPCN compound library, this assay may have been run as two or more separate campaigns, each campaign testing a unique set of compounds. All data reported were normalized on a per-plate basis. Possible artifacts of this assay can include, but are not limited to: dust or lint located in or on wells of the microtiter plate, and compounds that modulate well fluorescence. All test compound concentrations reported above and below are nominal; the specific test concentration(s) for a particular compound may vary based upon the actual sample provided by the MLSMR. The MLSMR was not able to provide all compounds selected for testing in this assay.
Categorized Comment - additional comments and annotations
From PubChem:
Assay Format: Cell-based
From ChEMBL:
Assay Format: Cell-based
Assay Type: Functional
Result Definitions
* Activity Concentration. ** Test Concentration.
Additional Information
Grant Number: GM031693
Data Table (Concise)


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To Tame the World: What terrifies us about reality pushes us toward its Creator.
We can understand why man, modern man in particular, would like to mop the floors and bleach the walls. We might not be able to tame reality, but we can tame our perception of reality. We intellectualize in order to feel in control.


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Practice Philosophy
Our goal is to bring patients into the diagnosis process and devise customized plans that target their specific objectives. It's not what we think our patients need; it's about what is important to the patient. We consider the initial consultation an essential learning experience for both doctor and patient. Only when we have a clear understanding of patients expectations can we develop an appropriate treatment plan. We distinguish ourselves by the quality of our results and our commitment to providing the highest level of care.
Dr. Geldner specializes in cosmetic surgery of the face and body including:
· Face Lift
· Neck Lift
· Brow Lift
· Blepharoplasty
· Rhinoplasty
· Lip Augmentation
· Cheek Augmentation
· Breast Augmentation
· Breast Lift
· Breast Reduction
· Abdominoplasty
· Liposuction
· Ab-Etching
· Gynocomastia
· Body lift
· Arm lift
· Leg Lift
· Buttock Enhancement
· Fat Transfers
· Botox
· Fillers
A consultation with Dr. Geldner is the first step toward an improved you
During the initial visit, it is important for Dr. Geldner to learn the details for you situation and for you to learn what surgical techniques Dr. Geldner recommends. You should discuss why you want the surgery, your expectations and desired outcome. In addition, you will also have the opportunity to discuss topics such as the location where your surgery will be performed, anesthesia and recovery time.
During the visit, our staff will also be available to talk with you about any questions you might have. They will then help you schedule your procedure if you desire, and discuss the financial considerations as well. Our goal is that you are confident with your decision.
Location & Office Hours
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680 North Lake Shore Drive
Chicago, IL 60611
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Cinematographer John Bailey's observations about art and artists
Catalog for Storm King exhibition.
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For more than 15 years, our intensive TESOL Certificate Program has offered a unique balance of theory and practice in Teaching English to Speakers of Other Languages. Starting Summer 2015, we are pleased to announce that our rigorous program will continue in a blended learning format with half of the instruction taking place online and half of the instruction taking place onsite, at Teachers College, Columbia University. We are offering the TESOL Certificate Program in an intensive format in the summer and in a part-time format, spread out over the Fall and Spring semesters from October to April.
The TESOL Certificate Program is ideal for recent college students, current teachers who want to improve their skills, and career-changers.
Please note: The application deadline for the part-time Fall-Spring program is August 25, 2015 for all applicants.
News: TESOL Certificate Program Students Complete Summer Intensive at TC
TESOL Cert Program Embraces Online Classroom in New Blended Learning Format
A Window Into Our Program
Theoretical Foundation
With its close affiliation with the graduate program in TESOL & Applied Linguistics, the TESOL Certificate program offers a theoretical foundation grounded in current research by experts in the field of TESOL. Students will gain a strong foundation in Classroom Practices, Second Language Acquisition, Pedagogical English Grammar, Second Language Assessment, and Intercultural Communication
Practical Training
Our students will gain practical application of the theoretical knowledge through supervised student teaching at our on-campus Community Language Program and intense senior teacher mentoring.
Meet Our Alumni
Alumni, 2014
"Best eight weeks I've ever spent were at the TC TESOL Cert Program. Wonderful teachers, classmates and curriculum. Hard work, but it has paid off as I am now happily teaching two ESL classes a week as I embark on my post-retirement career."
Alumni, 2014
"I can't think of a better move for a career-changer who is interested in entering the field of education than to spend a summer with some amazing colleagues and the outstanding faculty at the Teachers College TESOL program. Leave any worry at the door if you are concerned about being a student who hasn't stepped foot into classroom for a while. You are going to find a warm and welcoming environment which definitely embraces all manner of diversity -- including 'the age thing.' Do yourself a huge favor: sign up and go!"
Alumni, 2014
"I was not sure what to expect when I was accepted into Columbia's TESOL Certificate Program. It had been 30 years since I was in a classroom! What I found were wonderfully diverse classmates (diverse in age, experience and nationality), dedicated teachers, challenging assignments and a fascinating teaching experience. We worked hard, acquired a tremendous amount of new knowledge and laughed a lot with each other and our teachers. It was indeed a challenging 8 weeks, but we were supported, motivated and encouraged by our classmates, teachers and staff. And I was totally prepared to plunge into private tutoring in the fall. I highly recommend this program."
Alumni, 2013
"If you are interested in entering the field of TESOL, set aside one summer for this program. You will not regret it."
Alumni, 2013
"The program is first rate, in a class of its own. The experience of moving through it is well worth the time, effort and cost."
Alumni, 2013
"If you are ready for a tough yet rewarding life-changing experience, sign up for the TESOL Cert program. You'll learn from a group of incredibly dedicated teachers and fabulous classmates from all over the world."


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Test ID: NAGS
Hexosaminidase A and Total Hexosaminidase, Serum
Useful For Suggests clinical disorders or settings where the test may be helpful
Carrier detection and diagnosis of Sandhoff disease
Carrier detection and diagnosis of Tay-Sachs disease (testing option-this is not the recommended test)
Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request
This test is appropriate for carrier detection and diagnosis of Sandhoff disease. Refer to NAGR / Hexosaminidase A and Total, Leukocytes/Molecular Reflex or NAGW / Hexosaminidase A and Total Hexosaminidase, Leukocytes for carrier detection and diagnosis of Tay-Sachs disease.
See Tay-Sachs Disease Carrier Testing Protocol in Special Instructions.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Tay-Sachs disease and Sandhoff disease are lysosomal storage disorders, also referred to as GM2 gangliosidoses, caused by deficiencies of the enzymes hexosaminidase A and hexosaminidase B, respectively. These isoenzymes are dimers that differ in their subunit composition. Hexosaminidase A is a heterodimer composed of 1 alpha and 1 beta subunit (alpha-beta), while hexosaminidase B is a homodimer composed of 2 beta subunits (beta-beta). The defective lysosomal degradation and the excessive accumulation of GM2 ganglioside and related glycolipids results in the development of the clinical symptomology observed in Tay-Sachs and Sandhoff diseases.
Tay-Sachs Disease:
Tay-Sachs disease is caused by a deficiency of hexosaminidase A due to a defect in the alpha subunit. This autosomal recessive condition results from 2 mutations in the HEXA gene, which encodes for the alpha subunit of hexosaminidase. Individuals with Tay-Sachs disease have a deficiency in hexosaminidase A; those with higher residual enzyme activity may have a milder clinical presentation with a later age of onset.
The acute infantile form typically presents with progressive motor deterioration beginning at 3 to 6 months of age. Patients exhibit weakness, hypotonia, and decreasing attentiveness. Motor skills learned previously, such as crawling or sitting alone, are nearly always lost by age 1. Other symptoms include rapid diminishing of vision, seizures, macroencephaly due to cerebral gliosis, and the characteristic cherry-red spot in the retina. Affected individuals typically do not survive past age 5.
The juvenile or subacute form of Tay-Sachs disease often presents between 2 and 10 years with ataxia and clumsiness. Patients develop difficulties with speech and cognition. Neurologic features progressively worsen and death is typically 2 to 4 years later.
Disease progression is slower in patients with chronic or adult-onset Tay-Sachs disease. Early signs and symptoms may be subtle and nonspecific, involving muscle and/or neurologic findings, often resulting in initial misdiagnoses. Affected individuals may exhibit abnormalities of gait and posture, spasticity, dysarthria (loss of speech), and progressive muscle wasting and weakness. Cognitive impairment, dementia, or psychiatric findings are observed in some patients. Significant clinical variability exists both between and within families.
The carrier frequency of Tay-Sachs disease is increased in certain groups including individuals of Ashkenazi Jewish, Celtic, and French Canadian ancestry. A common cause of false-positive carrier screening by enzyme analysis, particularly among individuals of non-Ashkenazi Jewish descent, is due to the presence of a pseudodeficiency allele. Such sequence variations are not associated with disease, but result in the production of a hexosaminidase A enzyme with decreased activity towards the artificial substrate typically used in the enzyme assay. The recommended testing strategy is to order NAGR / Hexosaminidase A and Total, Leukocytes/Molecular Reflex, which begins with enzyme analysis and when the percent of hexosaminidase A enzyme is low, reflexes to the molecular panel which includes the most common mutations observed in these high-risk populations and 2 common pseudodeficiency alleles.
Sandhoff Disease:
Sandhoff disease (deficiency of hexosaminidase A and B due to a defect in the beta subunit) is an autosomal recessive condition resulting from 2 mutations in the HEXB gene, which encodes for the beta subunit of hexosaminidase. Individuals with Sandhoff disease have deficiencies in both hexosaminidase A and hexosaminidase B. Phenotypically, patients with Sandhoff disease present with features very similar to Tay-Sachs disease including variability in age of onset and severity. Enzyme analysis is generally required to distinguish between the 2 disorders. Unlike Tay-Sachs disease, Sandhoff disease does not have an increased carrier frequency in any specific population.
Diagnostic and Carrier Testing:
Testing for Tay-Sachs and Sandhoff diseases occurs by analysis of hexosaminidase A, a heat-labile enzyme, and total hexosaminidase (hexosaminidase A plus hexosaminidase B). When testing the enzyme, an artificial substrate is most commonly used. The total hexosaminidase is quantified. Following this, heat inactivation of hexosaminidase A occurs with a second measurement of the total enzyme level. From this, the percent hexosaminidase A is calculated. Biochemically, Tay-Sachs disease is characterized by normal total hexosaminidase with a very low percent hexosaminidase A. Carriers of Tay-Sachs disease are asymptomatic, but have intermediate percent hexosaminidase A in serum, leukocytes, and cultured fibroblasts. Follow-up molecular testing is recommended for all individuals with enzyme results in the carrier or possible carrier ranges to differentiate carriers of a pseudodeficiency allele from those with a disease-causing mutation. In addition, this allows for the facilitation of prenatal diagnosis for at-risk pregnancies.
A very small group of patients affected with Tay-Sachs disease have the B1 variant. In the presence of an artificial substrate, the B1 variant allows for a heterodimer formation of hexosaminidase A and exhibits activity. However, in vivo the B1 variant hexosaminidase A is inactive on the natural substrate. Thus, with the artificial substrate, these patients appear to be unaffected. Individuals with the B1 variant of Tay-Sachs disease must be distinguished using a natural substrate assay (MUGS / Hexosaminidase A (MUGS), Serum). This testing should be considered if one of the other assays indicates normal or carrier results and the suspicion of Tay-Sachs disease remains high.
Hexosaminidase testing using the artificial substrate provides an indirect assay for Sandhoff disease. Affected individuals exhibit very low total hexosaminidase with a disproportionately high percent hexosaminidase A due to alpha subunit homodimer formation. Carriers of Sandhoff disease are asymptomatic but have intermediate levels of total hexosaminidase with high percent hexosaminidase A in serum, leukocytes, and cultured fibroblasts. However, not all individuals with this pattern are true carriers of Sandhoff disease and follow-up molecular testing is recommended. In addition, molecular analysis allows for the facilitation of prenatal diagnosis for at-risk pregnancies. Testing hexosaminidase using the natural substrate does not identify homozygotes or heterozygotes for Sandhoff disease.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
< or =15 years: > or =20 nmol/min/mL
> or =16 years: 10.4-23.8 nmol/min/mL
< or =15 years: 20-90%
> or =16 years: 56-80%
Interpretation Provides information to assist in interpretation of the test results
Interpretation is provided with report.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
This test cannot be performed on pregnant females.
GM2 activator deficiency (GM2-gangliosidosis, AB variant) is a rare disorder with clinical features similar to Tay-Sachs and Sandhoff diseases; however, levels of both hexosamindase A and B are normal. GM2 activator deficiency cannot be identified through testing offered at Mayo Medical Laboratories.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Delnooz CCS, Lefeber DJ, Langemeijer SMC, et al: New cases of adult-onset Sandhoff disease with a cerebellar or lower motor neuron phenotype. J Neurol Neurosurg Psychiatry 2010;81:968-972
2. Gravel RA, Kaback MM, Proia RL, et al: The GM2 gangliosidosis. In The Metabolic and Molecular Bases of Inherited Disease. Eighth edition. Edited by CR Scriver, AL Beaudet, WS Sly, et al. New York, McGraw-Hill Book Company. Available at www.ommbid.com. Accessed 11-17-10
3. Maegawa GH, Stockley T, Tropak M, et al: The natural history of juvenile or subacute GM2 gangliosidosis: 21 new cases and literature review of 134 previously reported. Pediatrics 2006 Nov;118(5):e1550-1562
4. O'Brien JS, Okada S, Chen A, Fillerup DL: Tay-Sachs disease: detection of heterozygotes and homozygotes by hexosaminidase assay. N Engl J Med 1970;283:15-20


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New Employee Orientation 2014 – 2015
Upon completing orientation, new faculty and staff will:
Resources for New Employees:
New Full time Employee Orientation / September, 2014
Orientation, Day 1: Tue., September 9, 2014; 9:00 AM – 4:00 PM; Kirsch Ctr, room KC-112
New Part-time Faculty Orientations, 2014–2015
Fall Quarter: Tue., September 16; 1:30 – 6:30 PM; room MLC-260
New part-time faculty are encouraged to attend a De Anza College orientation. This meeting will include a nuts-and-bolts session with an overview of the Faculty Resource Guide, and an introduction to the culture and organization of De Anza College. Technology training will include an introduction to the De Anza College internet e-mail (Outlook) and portal system (for accepting your contract, downloading class lists, submitting grades on line, and communicating with your students).
New Classified Professionals Orientations
Scheduled on an as-needed basis.
New classified staff are encouraged to attend a De Anza College orientation. This meeting will include an introduction to the culture and organization of De Anza College, staff development and professional growth, the differences between union and Classified Senate, and the classified evaluation process. Technology training will review e-mail on Outlook or OWA, online time reports (LiquidOffice), how to access your MyPortal account, and Outlook Calendar Basics.
Full Agenda
Staff and Organizational Development


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Enrollment Management and Marketing
A student's potential is demonstrated by much more than a test score. Learn how DePaul's test-optional admission program encourages talented and promising students to pursue their educational dreams.
Taking the opportunity to upgrade the enrollment process for
students, DePaul developed an integrated approach to managing related
services. Find out more about the improvements developed in DePaul
While graduation rates have been on the rise over the past decade at DePaul, there is ongoing work to keep improving. Read more about the innovative retention framework and initiatives driving these efforts.
CEO Initiative benefits Chicago employers and studentsRead more in NewslineDreamWorks' Visit to DePaul Provides Valuable InsightsRead more in Enrollment Matters
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Brake Drums at 1A Auto
What are Brake Drums and where are they Located?
Your vehicle's brake drums are major components in a drum brake system. A drum brake system consists of brake drums, shoes, backing plates and wheel cylinders. Like brake rotors, automotive brake drums are made from cast iron, bolt onto the wheel hubs or axles, and spin at the same rate as the wheels. However all of the components are confined to the inside of the drum. Inside each brake drum sits one wheel cylinder and two brake shoes, which are bolted to the backing plate. When you press the brake pedal, hydraulic pressure is transmitted to wheel cylinder causing the pistons to expand, pushing the brake shoes against the inside surface of the drum. The friction that this creates is what allows the vehicle to slow to a stop. In a nutshell, your vehicle's brakes convert kinetic energy to thermal energy.
Most vehicles today have four brake discs. However, at one time drum brakes were the standard for all vehicles, and rear drum brakes are still found on many vehicles today. If a car or truck is only equipped with brake drums, then it will have one drum for each wheel in the front of the vehicle and one for each wheel in the rear of the vehicle. If a car or truck only has brake drums in the rear of the vehicle, then the vehicle will have two front brake rotors and two rear brake drums.
One advantage of a drum brake system is that the brake shoes will generally last longer than pads in a disc brake system, since there is a larger friction material contact area. However, due to the design of drum brakes, they do not dissipate heat as well as a disc brake system. As heat builds within the brake drum, the brakes become less affective.
How do I Know if my Brake Drums Need to be Replaced?
Brake drums can be resurfaced, or machined as long as there is enough material to do so. All brake drums have a discard diameter determined by the manufacturer, which is the maximum inside diameter the drum can be machined to before they are deemed unsafe and must be replaced (this information is often stamped into the outside of the drum itself). By using a micrometer, you should measure the inside diameter at multiple points to ensure the drum is not out of round and is within specification.
It is recommended to measure the drums every time you inspect the brakes or replace the brake shoes, as well as to regularly inspect the brake drum assembly for any signs of cracking, rust, corrosion or uneven friction surface. At one time it was very common to resurface brake drums, however today it is often more cost effective to replace the drums rather than machining them.
Need a Brake Drum Replacement?
Having properly functioning brakes on your car or truck is an absolute must for your own safety as well as for the safety of others. Since brake drums are an important component of a vehicle's drum brake system, if they are worn out, then replacement brake drums are needed ASAP. At 1A Auto, we carry a full line of high quality aftermarket brake drums, including both front brake drum and rear brake drum assemblies, for many makes and models.
At 1A Auto, we make shopping for a brake drum replacement for your car, truck, SUV or van easy - we're here to help you select the right part for your vehicle! Call our customer service toll free at 888-844-3393 if you have any questions about our aftermarket brake drums, warranty, compatibility or to purchase, or you can buy online right here at 1aauto.com. Restore the safety of your vehicle and order a brake drum replacement from 1A Auto today!


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DEADLINE TO GIVE: Oct 31, 2011
In October, The Nature Conservancy turned sixty and we'd love it if you'd celebrate your birthday with us!
Whenever it's your birthday, give it up for nature conservation by asking all of your family and friends to skip the gifts and instead, make a donation on your behalf.
To make it incredibly easy for all to donate and celebrate your special day…
You'll not only be helping to protect nature but all who donate or raise at least $60 on their page will be recognized at the end of our celebration and those raising $600 or more will receive additional special recognition online.
We're so excited for our 60th year and thank you for helping us grow over the years into the world's leading conservation organization. TNC now works in more than 30 countries on five continents and on behalf of every habitat from forests to coral reefs, and we couldn't have done it without you.
Thanks again for all of your support and we look forward to having you create your page and be part of the celebration this year.
The Nature Conservancy


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Conservative justices skip State of the Union
The conservative wing of the U.S. Supreme Court was absent from President Obama's Tuesday State of the Union address.
Justices Samuel Alito, Clarence Thomas and Antonin Scalia declined to join their six other colleagues at the prime time address to Congress.
During Obama's 2010 address, Alito was seen whispering the words "not true" during Obama's speech. Obama used his address to blast the court for their 2010 Citizens United case which altered the rules on corporate and union funding of elections.
In the aftermath of that speech, Alito complained that the justices were expected to sit in the House chamber "like the proverbial potted plant" and that it was now an awkward experience.
Read more about: Supreme Court, Antonin Scalia, State Of The Union, Samuel Alito, Clarence Thomas, State Of The Union 2013
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Redlight King's Kaz on Writing About Life, Feeling Comfortable As an Artist
"I love doing what people saying we can't do," laughs Kaz, singer and creator of Redlight King.
That statement sort of sums up Kaz's entire career. Born Mark Kasprzyk, he got his start in the music business 15 years ago as a rap-


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Hidden link to Carlisle's rich Roman past revealed - or is it?
Published at 10:11, Friday, 17 February 2012
Another possible remnant of the Romans may have been uncovered in Carlisle.
Sides of the plinth surrounding the Market Cross in the city centre were this week removed as part of restoration work
And what has been exposed has raised questions about the historical importance of what has been inside it for hundreds of years.
The plinth of the landmark, in front of the Old Town Hall, is basically a hollow stone box surrounding a stone column. But that stone column may have some historical significance.
The more modern cross, built in 1682, was created on the site of an older cross, which some think might date back to the Romans.
Now, as stone masons, building experts and historians have been able to take a closer look at the older column inside, questions have been raised about how old it actually is.
David Kay, building and facilities manager with Carlisle City Council, believes it is possible that the stone inside is historically important.
It is likely that those who built the "new" cross may have thought it significant because it seems the stone may have made building the replacement more difficult.
Rather than taking the simple option of building a solid base to mount the stone column on to, they have built it using a hollow stone box.
The chance to see what lies inside the Market Cross has come as work takes place to stabilise the structure, which has a lion on its top.
Mr Kay said: "I have been looking forward to seeing this for a while.
"I was hoping there would be some sort of markings that would give us a clue as to how old it was, but there aren't.
"There has been a cross on this site since Roman times. It is recorded that this one was built on the site of the previous market cross.
"My thought is that the cross in the middle is the spine of the original cross and that they have built around this and on top of it."
Historians have, however, been unable to confirm whether the stone inside the plinth could date back to Roman times after viewing it this week.
"They don't seem convinced that this is the original market cross. There are no markings on it to suggest that it is," Mr Kay added.
It may be years again before those interested can get such a close inspection of the inside of the plinth.
Carlisle Market Cross – also historically known as Caril Cross – is a grade one listed structure.
The lion on top of it is holding a scroll with the city arms on it.
Below it, are four sundials with ball and spear finials at its corners. It was first listed in 1949.
Each of the sundial faces has incised Roman numerals and painted metal gnomons.
Scaffolding and boarding has surrounded the Market Cross since stonemasonry specialists Askins and Little started work there late last month.
Work on the structure is being paid for by Carlisle City Council and English Heritage.
Despite the work taking place, the monument is not structurally insecure. The erection of the scaffolding is standard practice.
The statue, which is famous worldwide, was completely renovated and repainted in 2009.
Serious cracks were found in it and stonemasons and structural experts were drafted in to restore the monument to its former glory.
Work on the cross has been sanctioned by English Heritage.
Published by http://www.cumberlandnews.co.uk
Have your say
Curious enough I have considered it might be the remains of the last Dalek having been destroyed after they exterminated the population in the year 1050. The records of our city forefathers and many charters seemingly were destroyed (by a fire) a hundred or so, years later, so maybe when the doc comes back with his tardis we'll find out what it was for. Despite the questioning no one has since concluded what the stone box was for, obviously not a draft version of the apple iPad.However three italian cherries for first one to respond on what seems no particular interest to many in regard comments with the last attempt by myself in February. Nice to see the restored Carlisle Market Cross with hopefully a very longterm union (England and Scotland) crown. Be just and Fear Not .... Everyones writing is not perfect but at least many a time the N&S responds with the merit of contributing
many a comment within the website's terms. I'll sit the night in the stocks awaiting rotten tomatoes from the present vegs (or fruit) in the Greenmarket but you should beware it was'nt a Roman leader Hadrian that could not pronounce his 'h's but a prime minister that saved the nation from many a book being burned and much worse. Maggie the nations PM had speech speaking problems. I don't look for faults in others but just happy they contribute to the community I live. Captain Bligh said our language was alike the Tahitan language in that it was very complex and devious as our own. I'd rather have the talented NUT FRH, or RVI than CIC. Their again BUT General might be same as all highly Qualified staff in NHS. The expensive new Carlisle police station at Durranhill is now further away from the town and the scotch dyke border and last time I went they had trouble locating a biro.
roy.....what is it (in plain english please)that you are actually trying to say.....are you worried about the black death fear not you have the talented staff at cic to assist...if its maurauding scots we have an able police force.....as the carlisle motto says "be just and fear not"
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text:
- Independent
- The Enterprise
- The Recorder
Christopher S. Honig, 32, of Lusby was found not guilty Friday by a Calvert County Circuit Court jury of inappropriately touching and soliciting sexual favors from a then-15-year-old girl between August and December of 2011.
Honig was initially charged in August 2012, one year after the initial alleged incident, and later indicted on one count of fourth-degree sex offense and sexual solicitation of a minor.
The girl, now 16, was the first witness to testify during the trial, which began Wednesday, Feb. 6. She testified she has known Honig since she was in about the eighth grade and considered him a father figure. Honig used to give her rides to her friend's house, the girl testified, and he never made her feel uncomfortable until June 2011 when "he got really weird."
The witness testified that during the fall of 2011, Honig was giving her a ride to a friend's house and she began talking to him about her then-boyfriend. She said she was worried her then-boyfriend was interested in another girl, who she said was prettier than her. At that time, she testified, Honig told her to "let me be the judge of that" and told her to pull her tank top straps down. Honig pulled off onto the side of the road and started touching her, the girl said. She said Honig told her she could not tell anyone because he would go to jail.
When Assistant State's Attorney Kathryn Marsh asked the girl why she pulled her tank top down when Honig asked her to, the girl said she had never been in a situation like that before and did not know how to say no.
On another occasion in the fall of 2011, Honig had driven the girl to his mother's house to pick up a credit card to go get food, the girl said, when he asked her to take her sweatshirt off and pull her tank top down. Honig asked her to perform a sexual act if he paid her, and she said no, the witness testified.
When Marsh again asked her why she did what Honig asked her to do, the girl said, "He's a big guy. I didn't want to make him angry."
The girl also testified about an incident in St. Mary's County and an incident that occurred in June 2012, for which Honig was not charged but was allowed as evidence in the trial.
She said at a home in St. Mary's County, she was sitting on a bed with Honig when he asked her to sit in between his legs and unbutton her pants, and he then began touching her inappropriately. The girl then testified that in June 2012, Honig was giving her a driving lesson when he asked her to perform a sexual act if he purchased her learner's permit for her.
Several weeks after the June 2012 incident, the girl testified, she told Douglas Lawrence about the incidents with Honig.
During the trial, Lawrence testified that the girl asked him not to tell anyone, but later told the girl's mother after she overheard Lawrence and the girl talking about Honig. The mother testified that after she found out about what Honig allegedly had done, she took her daughter to the Maryland State Police Prince Frederick barrack July 10, 2012, and filed a police report.
Tfc. West, of the MSP Prince Frederick barrack, testified he took the initial report from the girl and her mother and then forwarded the information to Det. Jernigan of the Calvert Investigative Team. Once she was assigned to the case, Jernigan contacted the girl and interviewed her.
Jernigan testified she and Det. Sgt. Naughton with the sheriff's office went to Honig's mother's house after interviewing the girl, but he was not there. Jernigan said Naughton called Honig's cellphone and left a voicemail asking him to contact them, which he later did. Honig agreed to meet Jernigan and Naughton at the sheriff's office for an interview, which was recorded.
An edited version of the recording of the interview was played during the trial for the jury to hear. Retired judge Warren Krug told the jury the interview was lengthy and had "extraneous" or "inadmissible" information, which is why the recording was edited.
In the beginning of the interview, which was recorded at 2 p.m. Aug. 1, 2012, Honig denied touching the girl inappropriately or asking the girl to perform a sexual act. Naughton, who conducted the interview, then told Honig the original complaint was made immediately after the incident happened and they had "discernible male DNA" from a DNA swab they took from the girl's skin where she alleged he touched her.
Naughton asked how he would explain it if it was his DNA on the girl, and Honig said it may have been from when he was looking at a bug bite under her armpit she had showed him or from when they were wrestling. When Naughton asked whether he had asked the girl to perform a sexual act, Honig said he often jokes about things like that with the girl.
"You remember everything about everything, but you stop short about" touching the girl or asking her for sexual favors, Naughton said on the recorded interview to Honig. Naughton then asked whether "it was a lawful or unlawful groping," to which Honig replied, "It was lawful." Honig, during the recorded interview, told Naughton he was tickling the girl when she "moved my hands lower and lower" and Honig told her to stop.
At one point during the recorded interview, Honig told Naughton and Jernigan he had trouble understanding and comprehending things and had been in special education classes in school.
Jernigan testified there was not actual DNA in the case, but Honig was told there was to see if his story would change.
Defense attorney Robyn Riddle called Honig as a witness and asked if he ever touched the girl inappropriately in the fall of 2011, to which Honig responded, "I did not touch her at all." When Riddle asked him if he had asked her to perform a sexual act while at his mother's house in the fall of 2011, Honig said he did not.
Although Honig was not charged for the alleged incident in St. Mary's County, Riddle asked him to explain what happened. Honig testified the girl was upset about something so they went into the bedroom to talk.
"I'm a giant kid," Honig said, so he started tickling her to try to cheer her up. He said he did not tell her to unbutton her pants and did not touch her inappropriately.
Honig testified he took the girl out for a driving lesson in June 2012 and offered to purchase her learner's permit for her, but did not ask her to perform a sexual act in return.
Riddle said that during the recorded interview, Naughton told Honig he could choose either lawful or unlawful groping to describe the events that took place with the girl and "you said, 'I'll take the lawful groping.' Why?" Honig said he thought he had to choose between the two and thought "groping" meant "horseplay." At the end of the interview, Honig testified, he "was scared" and felt like he needed to tell the police what they wanted to hear so he could leave.
Honig is scheduled Feb. 27 for another jury trial for similar allegations from another 16-year-old girl. In that case, Honig is charged with sexual abuse of a minor and fourth-degree sex offense.