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Most Cited Oral Oncology Articles
The most cited articles published since 2010, extracted from Scopus.
Human papillomavirus related head and neck cancer survival: A systematic review and meta-analysis
Volume 48, Issue 12, December 2012, Pages 1191-1201
M. A. O'Rorke | M. V. Ellison | L. J. Murray | M. Moran | J. James | L. A. Anderson
Human Papillomavirus (HPV) related oropharyngeal squamous cell carcinomas (OPSCCs) are reported to have improved prognosis and survival in comparison to other head and neck squamous cell cancers (HNSCCs). This systematic review and meta-analysis examines survival differences in HPV-positive HNSCC and OPSCC subtypes including tonsillar carcinoma in studies not previously investigated. Four electronic databases were searched from their inception till April 2011. A random effects meta-analysis was used to pool study estimates evaluating disease-specific (death from HNSCC), overall (all-cause mortality), progression-free and disease-free (recurrence free) survival outcomes in HPV-positive vs. HPV-negative HNSCCs. All statistical tests were two-sided. Forty-two studies were included. Patients with HPV-positive HNSCC had a 54% better overall survival compared to HPV-negative patients HR 0.46 (95% CI 0.37-0.57); the pooled HR for tonsillar cancer and OPSCC was 0.50 (95% CI 0.33-0.77) and HR 0.47 (95% CI 0.35-0.62) respectively. The pooled HR for disease specific survival was 0.28 (95% CI 0.19-0.40); similar effect sizes were found irrespective of the adjustment for confounders, HPV detection methods or study location. Both progression-free survival and disease-free survival were significantly improved in HPV-positive HNSCCs. HPV-positive HNSCCs and OPSCCs patients have a significantly lower disease specific mortality and are less likely to experience progression or recurrence of their cancer than HPV-negative patients; findings which have connotations for treatment selection in these patients. © 2012 Elsevier Ltd. All rights reserved.
Feasiblity of transoral robotic hypopharyngectomy for early-stage hypopharyngeal carcinoma
Volume 46, Issue 8, August 2010, Pages 597-602
Young Min Park | Won Shik Kim | Hyung Kwon Byeon | Armando De Virgilio | Jin Sei Jung | Se Heon Kim
Conventional surgical approaches for hypopharyngeal carcinomas have a great risk for developing treatment-related morbidity. To minimize this morbidity, hypopharyngectomy by transoral robotic surgery (TORS) was performed, and the efficacy and feasibility of this procedure were evaluated. TORS was performed using da Vinci Surgical Robot (Intuitive Surgical Inc., Sunnyvale, CA) in 10 patients with T1 or T2 pyriform sinus cancer and posterior pharyngeal wall cancer. FK retractor (Gyrus Medical Inc., Maple Grove, MN) was used for transoral exposure of the lesion. A face-up 30-degree endoscope was inserted through the oral cavity and two instrument arms were located in both sides of the endoscope. Pyriform sinus was totally resected as a cone-shape from the vallecular to apex region, and ipsilateral arytenoid cartilage was saved for function preservation. The aryepiglottic fold was resected medially. Laterally, the inner perichondrium of the thyroid cartilage was peeled off after perichondrium was incised horizontally to make sure of the safe margin of antero-lateral portion. The posterior margin is an inferior constrictor muscle of the posterior pharyngeal wall. We evaluated the robotic set up time, robotic operation time, blood loss, surgical margins, swallowing time, decannulation time, and surgery related complications. Transoral robotic hypopharyngectomy was performed successfully in all 10 patients. The mean robotic operation time was 62.4 min, and an average of 17.5 min was required for the setting of the robotic system. There was no significant perioperative complication in the cases. Swallowing function returned to all patients within 8.3 days average. Decannulation was carried out within an average of 6.3 days after surgery. Transoral robotic hypopharyngectomy was feasible and ontologically safe technique for the treatment of early hypopharyngeal cancer. © 2010 Elsevier Ltd. All rights reserved.
Living with oral cancer: Epidemiology with particular reference to prevalence and life-style changes that influence survival
Volume 46, Issue 6, June 2010, Pages 407-410
Saman Warnakulasuriya
This review presents data on incidence, mortality, survival and trends on cancers of the lip, oral cavity and oropharynx using available recent data sources around the world. Oral and pharyngeal cancer, grouped together is the sixth most common cancer in the world. The review focuses primarily on prevalence of people still alive after an oral cancer diagnosis. In the world, there is close to a three quarter of a million people who previously had oral cancer and alive at 5 years after diagnosis. The proportion alive at 5 years is lower in less developed countries compared to earlier years. Within in Europe highest prevalence at 5 years is seen in Western Europe. Our prevention strategies for this high risk group should include offering smoking cessation and other risk reduction measures. Smoking cessation in particular improves prognostic outcomes reducing the risk of secondary disease by ∼2-3-fold. © 2010 Elsevier Ltd. All rights reserved.
Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas
Volume 49, Issue 1, January 2013, Pages 1-8
Mark W. Lingen | Weihong Xiao | Alessandra Schmitt | Bo Jiang | Robert Pickard | Paul Kreinbrink | Bayardo Perez-Ordonez | Richard C. Jordan | Maura L. Gillison
Background: Human papillomavirus (HPV) is a cause of oropharyngeal cancer, but a role for HPV in the etiology of oral cavity squamous cell carcinomas (OCSCC) remains uncertain. Methods: We sought to estimate the etiologic fraction for HPV among consecutive, incident OCSCC diagnosed from 2005 to 2011 at four North American hospitals. DNA and RNA purified from paraffin-embedded tumors were considered evaluable if positive for DNA and mRNA control genes by quantitative PCR. Fifteen high-risk (HR) HPV types were detected in tumors by consensus PCR followed by type-specific HR-HPV E6/7 oncogene expression by quantitative reverse-transcriptase PCR. P16 expression was evaluated by immunohistochemistry (IHC). A study of 400 cases allowed for precision to estimate an etiologic fraction of as low as 0% (97.5% confidence interval, 0-0.92%). Results: Of 409 evaluable OCSCC, 24 (5.9%, 95%CI 3.6-8.2) were HR-HPV E6/7 expression positive; 3.7% (95%CI 1.8-5.5) for HPV16 and 2.2% (95%CI 0.8-3.6) for other HR-HPV types. HPV-positive tumors arose from throughout the oral cavity (floor of mouth [n = 9], anterior tongue [6], alveolar process [4], hard palate [3], gingiva [1] and lip [1]) and were significantly associated with male gender, small tumor stage, poor tumor differentiation, and basaloid histopathology. P16 IHC had very good-to-excellent sensitivity (79.2%, 95%CI 57.9-92.9), specificity (93.0%, 95%CI 90.0-95.3), and negative-predictive value (98.6%, 95%CI 96.8-99.6), but poor positive-predictive value (41.3%, 95%CI 27.0-56.8) for HR-HPV E6/7 expression in OCSCC. Conclusion: The etiologic fraction for HR-HPV in OCSCC was 5.9%. p16 IHC had poor positive predictive value for detection of HPV in these cancers. © 2012 Elsevier Ltd. All rights reserved.
Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management
Volume 46, Issue 6, June 2010, Pages 423-425
Isaäc van der Waal
In spite of tremendous progress in the field of molecular biology there is yet no single marker that reliably predicts malignant transformation of a potentially malignant disorder of the oral mucosa. Therefore, it is recommended to excise or laser any oral of oropharyngeal leukoplakia/erythroplakia, if feasible, irrespective of the presence or absence of dysplasia. However, it is actually unknown whether such removal truly prevents the possible development of a squamous cell carcinoma. Therefore, lifelong follow-up is recommended at intervals of no more than 6 months. At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable. © 2010 Elsevier Ltd. All rights reserved.
Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1
Volume 46, Issue 3, March 2010, Pages 158-165
Yu Chih Chen | Charn Jung Chang | Han Shui Hsu | Yi Wei Chen | Lung Kuo Tai | Ling Ming Tseng | Guang Yuh Chiou | Shih Ching Chang | Shou Yen Kao | Shih Hwa Chiou | Wen Liang Lo
Bmi-1, a member of the Polycomb family of transcriptional repressors, is essential for maintaining the self-renewal abilities of adult stem cells. Bmi-1 has been demonstrated to play a role in tumorigenesis in head and neck squamous cell carcinomas (HNSCCs). A recent study has further suggested that ALDH1 may be considered to be a putative marker for HNSCC-derived cancer stem cells. However, the role that Bmi-1 plays in HNSCC-derived ALDH1-positive cells (HNSCC-ALDH1+) has yet to be determined. In this study, we demonstrated that HNSCC-ALDH1+ cells possess tumor initiating properties, are capable of self-renewal, and express higher levels of Bmi-1 as compared to HNSCC-ALDH1- cells. To further explore the functional role of Bmi-1 in HNSCC-ALDH1+ cells, we used a lentiviral vector expressing shRNA to knock down Bmi-1 expression (sh-Bmi-1) in HNSCC-ALDH1+ cells. Silencing of Bmi-1 significantly enhanced the sensitivity of HNSCC-ALDH1+ cells to chemoradiation and increased the degree of chemoradiation-mediated apoptosis that occurred. Importantly, knockdown of Bmi-1 increased the effectiveness of radiotherapy and led to the inhibition of tumor growth in nude mice transplanted with HNSCC-ALDH1+ cells. Kaplan-Meier survival analysis indicated that the mean survival rate of HNSCC-ALDH1+ tumor-bearing immunocompromised mice treated with radiotherapy was significantly improved by treatment with sh-Bmi-1 as well. In summary, these results suggest that Bmi-1 is a potential target for increasing the sensitivity of HNSCC cancer stem cells to chemoradiotherapy. © 2009 Elsevier Ltd. All rights reserved.
miR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis
Volume 46, Issue 3, March 2010, Pages 204-208
Shu Chun Lin | Chung Ji Liu | Jung An Lin | Wei Fan Chiang | Pei Shih Hung | Kuo Wei Chang
MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking miR-24 and using exogenous miR-24 expression indicated that miR-24 contributes to the growth of OSCC cells and that miR-24 may target p57. This study suggests that miR-24 is involved in the regulation of OSCC growth and that the miR-24's level in plasma may be validatable as a tumor marker for OSCC patients. © 2010 Elsevier Ltd. All rights reserved.
Oral cancer: Clinical features
Volume 46, Issue 6, June 2010, Pages 414-417
Jose Bagan | Gracia Sarrion | Yolanda Jimenez
Oral squamous cell carcinoma (OSCC) is a well-known malignancy that accounts for more than 90% of all oral cancers. In this article we will perform a brief review of its clinical characteristics and the differential diagnosis. Regarding symptoms, pain is the most frequent presentation and the tongue and the floor of the mouth have the highest occurrence. OSCC in its initial stages shows an erytholeukoplastic area without symptoms but in advanced stages there are ulcers and lumps with irregular margins which are rigid to touch. The different diagnosis should be established with other oral malignant diseases such as lymphomas, sarcomas and metastasis, which have rapid growth rates as opposed to the typical OSCC. © 2010 Elsevier Ltd. All rights reserved.
Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing
Volume 46, Issue 7, July 2010, Pages 492-496
Max Robinson | Philip Sloan | Richard Shaw
There is accumulating evidence that oropharyngeal squamous cell carcinomas (SCCs) that harbour oncogenic human papillomavirus (HPV) are biologically distinct and have a better prognosis. This information is a persuasive argument for the identification of these cancers in clinical practice. The concept of 'HPV related' SCC should be underpinned by knowledge that the malignant cells harbour a high risk HPV genotype and there is evidence of oncogenic viral protein expression with effects on cell signalling pathways. For satisfactory classification in clinical practice HPV tests should reliably work on fixed cells and tissue. There is evidence that detection of high risk HPV by consensus polymerase chain reaction (PCR) alone is insufficient to accurately classify tumours. However, there is convincing evidence that the detection of p16 protein by immunohistochemistry can be used as a surrogate marker for the elaboration of oncogenic HPV proteins. Recently, there have been calls for standardisation of HPV testing in head and neck cancers and two diagnostic algorithms have emerged: the first advocates screening for p16 by immunohistochemistry followed by detection of HPV DNA by in situ hybridisation: the second recommends detection of p16 followed by consensus PCR. The majority of pathology laboratories have the capability of delivering the first algorithm. Furthermore, the techniques employed are automated and are subject to stringent quality assurance measures; features that can deliver routine, accurate and cost effective HPV testing for oropharyngeal cancers. © 2010 Elsevier Ltd. All rights reserved.
Comorbidity in head and neck cancer: A critical appraisal and recommendations for practice
Volume 46, Issue 10, October 2010, Pages 712-719
Vinidh Paleri | Richard G. Wight | Carl E. Silver | Missak Haigentz | Robert P. Takes | Patrick J. Bradley | Alessandra Rinaldo | Alvaro Sanabria | Stanisław Bień | Alfio Ferlito
Comorbidity, the presence of additional illnesses unrelated to the tumor, has a significant impact on the prognosis of patients with head and neck cancer. In these patients, tobacco and alcohol abuse contributes greatly to comorbidity. Several instruments have been used to quantify comorbidity including Adult Comorbidity Evaluation 27 (ACE 27), Charlson Index (CI) and Cumulative Illness Rating Scale. The ACE 27 and CI are the most frequently used indices. Information on comorbidity at the time of diagnosis can be abstracted from patient records. Self-reporting is less reliable than record review. Functional status is not a reliable substitute for comorbidity evaluation as a prognostic measure. Severity as well as the presence of a condition is required for a good predictive instrument. Comorbidity increases mortality in patients with head and neck cancer, and this effect is greater in the early years following treatment. In addition to reducing overall survival, many studies have shown that comorbidity influences disease-specific survival negatively, most likely because patients with high comorbidity tend to have delay in diagnosis, often presenting with advanced stage tumors, and the comorbidity may also prompt less aggressive treatment. The impact of comorbidity on survival is greater in younger than in older patients, although it affects both. For specific tumor sites, comorbidity has been shown to negatively influence prognosis in oral, oropharyngeal, laryngeal and salivary gland tumors. Several studies have reported higher incidence and increased severity of treatment complications in patients with high comorbidity burden. Studies have demonstrated a negative impact of comorbidity on quality of life, and increased cost of treatment with higher degree of comorbidity. Our review of the literature suggests that routine collection of comorbidity data will be important in the analysis of survival, quality of life and functional outcomes after treatment as comorbidity has an impact on all of the above. These data should be integrated with tumor-specific staging systems in order to develop better instruments for prognostication, as well as comparing results of different treatment regimens and institutions. © 2010 Elsevier Ltd. All rights reserved.
MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation
Volume 47, Issue 3, March 2011, Pages 202-210
Cheng Chia Yu | Yi Wei Chen | Guang Yuh Chiou | Lo Lin Tsai | Pin I. Huang | Charn Yung Chang | Ling Ming Tseng | Shih Hwa Chiou | Sang Hue Yen | Ming Yung Chou | Pen Yuan Chu | Wen Liang Lo
Head and neck cancer (HNC) is a prevalent cancer worldwide. Let-7 has been shown to function as a tumour suppressor by regulating multiple oncogenic signalling pathways. However, the role of let-7 in head and neck cancer (HNC) and in HNC-associated tumour initiating cells (TIC) remains unclear. In this study, we first demonstrated that let-7a expression was significantly decreased but that Nanog/Oct4 expression was increased in HNC tissues as compared to adjacent normal cells. Expression of let-7a in recurrent HNC tissue and in regional metastatic lymph nodes of HNC patients was also significantly decreased, but Nanog/Oct4 expression was increased as compared to the expression levels in the parental tumours. Consistently, the stemness genes were significantly up-regulated and let-7a was down-regulated in HNC-ALDH1 + cells relative to HNC-ALDH1- cells. Furthermore, lentiviral-mediated let-7a overexpression could significantly inhibit the stemness signature and the chemoresistant abilities of HNC-ALDH1+ cells. Most importantly, overexpression of let-7 or knockdown of Nanog in ALDH1+ cells effectively blocked tumour metastasis and significantly prolonged survival time in ALDH1+-transplanted immunocompromised mice. Overall, restoration of let-7a in HNC and HNC-TIC may be a new approach for the therapeutic treatment of HNC in the future. These results show that let-7a negatively modulates the expression of stemness genes and plays a role as a tumour suppressor in HNC by eliminating the putative HNC-TIC population. © 2010 Elsevier Ltd. All rights reserved.
The biology of head and neck cancer stem cells
Volume 48, Issue 1, January 2012, Pages 1-9
Zhaocheng Zhang | Manoel Sant Ana Filho | Jacques E. Nör
Emerging evidence indicates that a small population of cancer cells is highly tumorigenic, endowed with self-renewal, and has the ability to differentiate into cells that constitute the bulk of tumors. These cells are considered the "drivers" of the tumorigenic process in some tumor types, and have been named cancer stem cells. Epithelial-mesenchymal transition (EMT) appears to be involved in the process leading to the acquisition of stemness by epithelial tumor cells. Through this process, cells acquire an invasive phenotype that may contribute to tumor recurrence and metastasis. Cancer stem cells have been identified in human head and neck squamous cell carcinomas (HNSCC) using markers such as CD133 and CD44 expression, and aldehyde dehydrogenase (ALDH) activity. The head and neck cancer stem cells reside primarily in perivascular niches in the invasive front where endothelial-cell initiated events contribute to their survival and function. In this review, we discuss the state-of-the-knowledge on the pathobiology of cancer stem cells, with a focus on the impact of these cells to head and neck tumor progression. © 2011 Elsevier Ltd. All rights reserved.
MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines
Volume 46, Issue 4, April 2010, Pages 317-322
Zhi wei Yu | Lai ping Zhong | Tong Ji | Ping Zhang | Wan tao Chen | Chen ping Zhang
MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression. They are strongly implicated in human cancers, including oral squamous cell carcinoma (OSCC). Evidence for the involvement of miRNAs as important regulators of chemosensitivity and chemoresistance in OSCC is not well understood. In this study, miRNA microarray was firstly used to compare the differential miRNAs levels between the cisplatin-sensitive tongue squamous cell carcinoma line (Tca8113) and its cisplatin-resistant subline (Tca/cisplatin). Three miRNAs of miR-21, -214, and -23a were validated by miRNAs real-time PCR, and intervened by anti-miRNA oligonucleotides (miR-214 and -23a) and pre-miRNA plasmid transfection (miR-21). Further relationship between miR-23a and DNA topoisomerase II beta (TOP2B) on the chemoresistance against cisplatin was studied. There were 19 out of 480 differential miRNAs between the Tca8113 and Tca/cisplatin cells. miR-214 and -23a were found increased as with chemoresistance against cisplatin in the Tca/cisplatin cells while miR-21 was found decreased as with chemosensitivity for cisplatin in the Tca/cisplatin cells. Intervention of these three miRNAs could decrease the chemoresistance against cisplatin in Tca/cisplatin cells. Transfection of anti-miR-23a into the Tca/cisplatin cells could increase the TOP2B protein expression. Our results suggest the existence of differential miRNAs with chemosensitivity and chemoresistance between the cisplatin-sensitive and resistant tongue squamous cell carcinoma lines. miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines. miR-23a is an up-stream regulator of TOP2B to realize the chemoresistance of cisplatin. © 2010 Elsevier Ltd. All rights reserved.
Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas
Volume 47, Issue 2, February 2011, Pages 83-91
Young Chang Lim | Se Yeong Oh | Yun Yi Cha | Sung Hak Kim | Xun Jin | Hyunggee Kim
A subpopulation of cancer stem cells (CSCs), but not the majority of non-tumorigenic cancer cells, in a variety of human malignancies plays a critical role in cancer cell proliferation, invasion, metastasis, and tumor recurrence post-therapies. We report the isolation of sphere-forming cells (squamospheres) from primary head and neck squamous cell carcinomas (HNSCCs), and characterization of their CSC properties. Squamospheres appeared within 2 weeks after seeding as single-dissociated cells obtained from primary HNSCC specimens in serum-free culture conditions. Real-time RT-PCR and immunocytochemistry assays revealed that a number of stem cell markers, including CK5, OCT4, SOX2, and nestin, were up-regulated in HNSCC-driven squamospheres. Fluorescence-activated cell sorting (FACS) analysis showed that squamospheres contain enriched side population cells compared to serum-induced differentiated squamosphere cells. Furthermore, HNSCC-driven squamospheres appeared to be chemoresistant to cisplatin, 5-fluorouracil (FU), paclitaxel and doxetaxel, and showed increased levels of ABCG2, one of the ATP-binding cassette (ABC) transporters. Of particular interest, in sharp contrast to subcutaneous injection of 1 × 106 differentiated squamosphere cells, as few as 100 squamosphere cells were able to give rise to tumors in nude mice. Altogether, we assert that primary HNSCC-driven squamospheres possess CSC properties, and its functional analysis may provide a novel tool for investigating the tumorigenic process of HNSCC. © 2010 Elsevier Ltd. All rights reserved.
Potential biomarkers in saliva for oral squamous cell carcinoma
Volume 46, Issue 4, April 2010, Pages 226-231
Jia Yo Wu | Chen Yi | Ho Ren Chung | Duen Jeng Wang | Wen Chien Chang | Sheng Yang Lee | Che Tung Lin | Yueh Chao Yang | Wei Chung Vivian Yang
Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC. © 2010 Elsevier Ltd. All rights reserved.
Moderate predictive value of demographic and behavioral characteristics for a diagnosis of HPV16-positive and HPV16-negative head and neck cancer
Volume 46, Issue 2, February 2010, Pages 100-104
Gypsyamber D'Souza | Hao H. Zhang | Warren D. D'Souza | Robert R. Meyer | Maura L. Gillison
Patients with HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are significantly different with regard to sociodemographic and behavioral characteristics that clinicians may use to assume tumor HPV status. Machine learning methods were used to evaluate the predictive value of patient characteristics and laboratory biomarkers of HPV exposure for a diagnosis of HPV16-positive HNSCC compared to in situ hybridization, the current gold-standard. Models that used a combination of demographic characteristics such as age, tobacco use, gender, and race had only moderate predictive value for tumor HPV status among all patients with HNSCC (positive predictive value [PPV] = 75%, negative predictive value [NPV] = 68%) or when limited to oropharynx cancer patients (PPV = 55%, NPV = 65%) and thus included a sizeable number of false positive and false negative predictions. Prediction was not improved by the addition of other demographic or behavioral factors (sexual behavior, income, education) or biomarkers of HPV16 exposure (L1, E6/7 antibodies or DNA in oral exfoliated cells). Patient demographic and behavioral characteristics as well as HPV biomarkers are not an accurate substitute for clinical testing of tumor HPV status. © 2009 Elsevier Ltd. All rights reserved.
Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma
Volume 48, Issue 8, August 2012, Pages 686-691
Zujian Chen | Yi Jin | Dongsheng Yu | Anxun Wang | Ishrat Mahjabeen | Cheng Wang | Xiqiang Liu | Xiaofeng Zhou
Objectives: MicroRNA deregulation is a critical event in head and neck squamous cell carcinoma (HNSCC). Several microRNA profiling studies aimed at deciphering the microRNA signatures of HNSCC have been reported, but there tends to be poor agreement among studies. The objective of this study was to survey the published microRNA profiling studies on HNSCC, and to assess the commonly deregulated microRNAs in an independent sample set. Materials and methods: Meta-analysis of 13 published microRNA profiling studies was performed to define microRNA signatures in HNSCC. Selected microRNAs (including members of miR-99 family) were evaluated in an independent set of HNSCC cases. The potential contributions of miR-99 family to the tumorigenesis of HNSCC were assessed by in vitro assays. Results: We identified 67 commonly deregulated microRNAs. The up-regulation of miR-21, miR-155, miR-130b, miR-223 and miR-31, and the down-regulation of miR-100, miR-99a and miR-375 were further validated in an independent set of HNSCC cases with quantitative RT-PCR. Among these validated microRNAs, miR-100 and miR-99a belong to the miR-99 family. Our in vitro study demonstrated that restoration of miR-100 to the HNSCC cell lines suppressed cell proliferation and migration, and enhanced apoptosis. Furthermore, ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor (IGF1R) and mechanistic target of rapamycin (mTOR) genes. Conclusion: In summary, we described a panel of frequently deregulated microRNAs in HNSCC, including members of miR-99 family. The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC, in part by targeting IGF1R and mTOR signaling pathways. © 2012 Elsevier Ltd. All rights reserved.
Oral mucositis
Volume 46, Issue 6, June 2010, Pages 452-456
Judith E. Raber-Durlacher | Sharon Elad | Andrei Barasch
Mucosal damage is one of the most common adverse effects of radiotherapy and of cytotoxic therapy for cancer. With prevalence between 10% and 100%, depending of the cytotoxic regimen and patient-associated variables, this morbid condition represents a significant problem in oncology. In this paper we address oral mucositis and discuss its pathobiology, risk factors, impact and management in view of the most recent evidence. Despite of clear progress and the development of clinical guidelines, what we currently have to offer to patients to manage mucositis and oropharyngeal pain is still inadequate. Expansion of the knowledge of the pathogenesis of mucositis as well as a better insight into individual risk factors will provide opportunities to improve management strategies. © 2010 Elsevier Ltd. All rights reserved.
Contemporary reconstruction of the mandible
Volume 46, Issue 2, February 2010, Pages 71-76
Mathew Bak | Adam S. Jacobson | Daniel Buchbinder | Mark L. Urken
Reconstruction of the mandible has evolved significantly over the last 40 years. Early attempts were often disfiguring and wrought with complications but with the introduction of free tissue transfer of well vascularized bone in the 1970's there was a significant improvement in outcomes. In recent years the harvest, inset, and microvascular anatomosis have been refined to the point that success rates are reported as high as 99% throughout the literature. Focus has now shifted to optimizing functional and aesthetic outcomes after mandible reconstruction. This paper will be a review defect classification, goals of reconstruction, the various donor sites, dental rehabilitation, new advances, and persistent problems. Reconstruction of segmental mandibular defects after ablative surgery is best accomplished using free tissue transfer to restore mandibular continuity and function. Reestablishing occlusion and optimizing tongue mobility are important to post-operative oral function. Persistent problems in oro-mandibular reconstruction relate to the effects of radiation treatment on the native tissue and include xerostomia, dysgeusia, osteoradionecrosis and trismus. These problems continue to plague the oral cancer patient despite the significant advances that allow a far more complete functional restoration than could be accomplished a mere two decades ago. © 2009 Elsevier Ltd. All rights reserved.
Advances and applications of oral cancer basic research
Volume 47, Issue 9, September 2011, Pages 783-791
Sabrina Daniela Da Silva | Alfio Ferlito | Robert P. Takes | Ruud H. Brakenhoff | Mev Dominguez Valentin | Julia A. Woolgar | Carol R. Bradford | Juan P. Rodrigo | Alessandra Rinaldo | Michael P. Hier | Luiz P. Kowalski
Cancer of the oral cavity accounts for almost 3% of cancer cases in the world. The incidence varies widely reflecting geographic differences in exposure to risk factors. The recent rise in younger age groups and females seen in many countries is of particular concern. Treatment and management of complications, locoregional recurrence and further primary tumors result in high morbidity and mortality especially when the disease is advanced stage at initial diagnosis. Progress in cancer research has provided abundant new knowledge about cellular processes and molecular biology underlying oral carcinogenesis and tumor progression. The present review attempts to summarize the current most widely-used research approaches and their application in the prevention, diagnosis, effective treatment, and improved outcome of oral cancer. © 2010 Elsevier Ltd. All rights reserved.
Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer
Volume 47, Issue 8, August 2011, Pages 725-731
Devasena Anantharaman | Manuela Marron | Pagona Lagiou | Evangelia Samoli | Wolfgang Ahrens | Hermann Pohlabeln | Alena Slamova | Miriam Schejbalova | Franco Merletti | Lorenzo Richiardi | Kristina Kjaerheim | Xavier Castellsague | Antonio Agudo | Renato Talamini | Luigi Barzan | Tatiana V. MacFarlane | Martin Tickle | Lorenzo Simonato | Cristina Canova | David I. Conway | Patricia A. McKinney | Peter Thomson | Ariana Znaor | Claire M. Healy | Bernard E. McCartan | Mia Hashibe | Paul Brennan | Gary J. MacFarlane
Tobacco and alcohol are major risk factors for upper aerodigestive tract (UADT) cancer and significant variation is observed in UADT cancer rates across Europe. We have estimated the proportion of UADT cancer burden explained by tobacco and alcohol and how this varies with the incidence rates across Europe, cancer sub-site, gender and age. This should help estimate the minimum residual burden of other risk factors to UADT cancer, including human papillomavirus. We analysed 1981 UADT cancer cases and 1993 controls from the ARCAGE multicentre study. We estimated the population attributable risk (PAR) of tobacco alone, alcohol alone and their joint effect. Tobacco and alcohol together explained 73% of UADT cancer burden of which nearly 29% was explained by smoking alone, less than 1% due to alcohol on its own and 44% by the joint effect of tobacco and alcohol. Tobacco and alcohol together explained a larger proportion of hypopharyngeal/laryngeal cancer (PAR = 85%) than oropharyngeal (PAR = 74%), esophageal (PAR = 67%) and oral cancer (PAR = 61%). Tobacco and alcohol together explain only about half of the total UADT cancer burden among women. Geographically, tobacco and alcohol explained a larger proportion of UADT cancer in central (PAR = 84%) than southern (PAR = 72%) and western Europe (PAR = 67%). While the majority of the UADT cancers in Europe are due to tobacco or the joint effect of tobacco and alcohol, our results support a significant role for other risk factors in particular, for oral and oropharyngeal cancers and also for UADT cancers in southern and western Europe. © 2011 Elsevier Ltd. All rights reserved.
Significance of site-specific prognosis of cancer stem cell marker CD44 in head and neck squamous-cell carcinoma
Volume 47, Issue 6, June 2011, Pages 510-516
Linda Lotta Kokko | Saija Hurme | Sanna Mari Maula | Kalle Alanen | Reidar Grénman | Ilpo Kinnunen | Sami Ventelä
In several recent studies, CD44 expression has been associated with aggressive behavior in cancers of different types. CD44 expression is also linked to cancer stem cells, which have been shown to play a significant role in tumor progression and poor prognosis in head and neck squamous cell carcinoma (HNSCC), as well as in other cancers. Although CD44 is a potential prognostic marker, it has not been adopted to wider clinical use as a part of treatment planning in HNSCC patients. The aim of this research was to study whether CD44 overexpression is associated with 5 year overall survival in HNSCC. We also studied site-specific associations between increased CD44 expression and 5 year overall survival. Associations between relative tumor CD44 expressions and smoking, heavy alcohol consumption, histological grade of cancer, TNM staging and HNSCC staging were also studied. In total, 135 paraffin-embedded blocks from HNSCC patients were stained immunohistochemically with a CD44 antibody and were classified by the anatomic location of the tumor. CD44 overexpression had statistically significant association with decreased 5 year survival rates when all HNSCC samples were studied (p < 0.001). Significant association between intense CD44 expression and poor 5 year survival rates was found in the patients with SCC of the oro- and hypopharynx (p < 0.001) and the larynx (p = 0.042). In patients suffering from HNSCC in the oral cavity, CD44 overexpression did not have a significant effect on overall 5 year survival rates. Heavy smoking of over 10 pack years had a significant association with tumor CD44 overexpression (p = 0.009). Only pharyngeal (p = 0.046) and laryngeal (p = 0.047) SCC, but not oral-cavity SCC, had statistically significant associations between heavy smoking and CD44 overexpression when HNSCC was studied in regional groups. Alcohol consumption and tumor grade did not have a significant association with the tumor's CD44 expression. Our results suggest that CD44 overexpression could be used as a sign of aggressiveness, in addition to the HNSCC staging, as a prognostic factor in pharyngeal and laryngeal HNSCC and to assist in treatment selection. © 2011 Elsevier Ltd. All rights reserved.
A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: Overall results and dose-risk relation
Volume 46, Issue 7, July 2010, Pages 497-503
Irene Tramacere | Eva Negri | Vincenzo Bagnardi | Werner Garavello | Matteo Rota | Lorenza Scotti | Farhad Islami | Giovanni Corrao | Paolo Boffetta | Carlo La Vecchia
Alcohol consumption, together with tobacco, is the best recognised risk factor for oral and pharyngeal cancers (OPC), but several important aspects of this association need to be further explored. In order to provide up to date and more precise quantification of the association between alcohol drinking and OPC risk, we conducted a meta-analysis of available data. We performed a PubMed search of articles published up to September 2009, and we identified 43 case-control and two cohort studies presenting results for at least three categories of alcohol drinking, including a total of 17,085 OPC cases. We derived meta-analytic summary estimates using random-effects models, and taking into account correlation between estimates. We also performed a dose-risk analysis using non-linear random-effects meta-regression models. The pooled relative risk (RR) was 1.21 (95% confidence interval, CI, 1.10-1.33) for ≤1 drink per day, and rose to 5.24 (95% CI, 4.36-6.30) for heavy alcohol drinking (≥4 drinks per day). The dose-risk analysis resulted in RR of 1.29 for 10 g ethanol/day, 3.24 for 50 g ethanol/day, 8.61 for 100 g ethanol/day, and 13.02 for 125 g ethanol/day. This meta-analysis provides more precise evidence of a gross excess of OPC risk for heavy alcohol drinkers. It also indicates an increased risk for moderate doses, i.e., ≤1 drink or 10 g ethanol/day. © 2010 Elsevier Ltd. All rights reserved.
Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
Volume 49, Issue 1, January 2013, Pages 79-85
Shao Hui Huang | Bayardo Perez-Ordonez | Ilan Weinreb | Andrew Hope | Christine Massey | John N. Waldron | John Kim | Andrew J. Bayley | Bernard Cummings | B. C. John Cho | Jolie Ringash | Laura A. Dawson | Lillian L. Siu | Eric Chen | Jonathan Irish | Patrick Gullane | Angela Hui | Fei Fei Liu | Xiaowei Shen | Wei Xu | Brian O'Sullivan
Objectives: To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC). Methods: OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(-) cohorts. Results: Median follow-up was 3.9 years. The DM rate were similar (11% vs. 15% at 3-years, p = 0.25) between the HPV(+) (n = 457) vs. the HPV(-) (n = 167) cases. While almost all (24/25) HPV(-) DM occurred within 2-years following RT (1 was at 2.1 years), 7/54 (13%) of HPV(+) DM were detected beyond 3 years (up to 5.3 years). Disseminating to >2 organs occurred in 18 (33%) HPV(+) vs. none in HPV(-). Post-DM survival rates were 11% vs. 4% at 2-years (p = 0.02) for the HPV(+) vs. HPV(-) cases respectively. 5/6 HPV(+) with lung oligo-metastasis were still alive with stable disease beyond 2-years after salvage procedures for DM (chemotherapy: 3; surgical resection: 2; radiotherapy: 1). Conclusions: Although DM rates are similar, the natural course of HPV(+) DM differs from that of HPV(-) patients: it may occur after a longer interval, often with a "disseminating" phenotype, and a small number may have prolonged survival after salvage for DM. © 2012 Elsevier Ltd. All rights reserved.
Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas
Volume 47, Issue 6, June 2011, Pages 487-496
Balázs Szabó | Györgyi A. Nelhubel | Adél Kárpáti | István Kenessey | Balázs Jóri | Csilla Székely | István Peták | Gábor Lotz | Zita Hegedus | Balázs Hegedus | Tibor Füle | Balázs Döme | József Tímár | József Tóvári
The significance of epidermal growth factor receptor (EGFR) signaling is well studied in a number of different tumors, but limited data is available with regard to head and neck squamous cell carcinoma (HNSCC). Since anti-EGFR therapies are currently under investigation in these malignancies as well, comprehensive information about the alteration of EGFR in HNSCC is necessary to design the most appropriate therapeutic protocols. We examined retrospectively the gene copy number of EGFR by FISH and the protein expression by immunohistochemistry using different epitope-specific antibodies in paraffin-embedded primary tumors of five different regions, from 71 HNSCC patients who had not been treated with anti-EGFR therapy. In seven cases corresponding lymph node metastases were also available for comparative analyses. We also determined the mutational status of tyrosine kinase (TK) domain (exon 19 and 21) and the extracellular deletion mutation (vIII) of EGFR, the KRAS mutation at codon 12 and the presence of HPV infection. Eight of the 71 cases (11.3%) showed EGFR gene amplification (most of them localized into the hypopharyngeal region) and the increased gene copy number (amplification + polysomy) was 43.7%. Despite pronounced intratumoral heterogeneity of EGFR protein expression being found, the high EGFR expression correlated with poor prognosis. On the other hand, the phosphorylation of EGFR was associated with prolonged survival. No mutations in the TK domain of EGFR were found in any of the HNSCC patients and only two cases were KRAS mutant at codon 12. We detected vIII deletion mutation of EGFR in 21% of the samples, but there was no statistically significant correlation between the presence of vIII mutant form and patient survival. EGFR vIII mutation was, however, associated with increased gene copy number. Fourteen of 71 cases (19.7%) were HPV-positive and the incidence of infection showed a decreasing tendency from the oral cavity towards the larynx. Interestingly, in contrast to previous findings, we could not observe improved survival in HPV-positive patients compared to non-infected patients, most probably due to the fact that the majority of these HNSCC patients were smokers and alcohol consumers. In conclusion, we found that increased EGFR protein levels and gene copy numbers (not gene amplification alone) have prognostic significance in the investigated HNSCC patient population. However, the relatively high incidence of the EGFR-vIII mutant form warrants careful therapeutic decision-making when choosing between different anti-EGFR treatment options. © 2011 Elsevier Ltd. All rights reserved.


text:
Heavy outflows from commodity ETPs as equities appeal – BlackRock
LONDON (Reuters) – Investors in commodity exchange traded products (ETPs) unwound their holdings to jump on the equity market rally in March, resulting in total redemptions of $3.2 billion globally, according to BlackRock data.
Gold suffered an investor exodus for a third consecutive month, bringing first-quarter ETP outflows to $9.2 billion, but white metals – silver, platinum and palladium – escaped the sell-off, BlackRock, the world's largest asset manager, said.
UK oil revival beckons as new technology, investors halt decline
LONDON, April 4 (Reuters) – New operators and better
technology are set to reverse a decline in Britain's North Sea
oil and gas output over the next few years, and could help the
country's economy return to health.
Although output is expected to decline another 3-6 percent
this year, it will rebound by almost a third by 2017 as some 50
oil and gas fields start production on the United Kingdom's
Continental Shelf, industry body figures show.
China keen to fix Britain's broken benchmark oilfield
LONDON, March 12 (Reuters) – China's state oil company is
prioritising a fix for Britain's biggest oilfield, the
accident-prone Buzzard, which plays a part in setting global oil
CNOOC has taken a controlling stake in the North Sea field
central to the price of benchmark Brent crude and which, every
time it shuts, can raise costs for some of China's oil imports.
Oil falls below $110 on ample supply
LONDON, March 8 (Reuters) – Brent crude oil futures fell
below $110 a barrel on Friday, pressured by higher-than-expected
supply from the North Sea and OPEC, and investors selling out of
commodities in favour of equities.
Brent futures fell $1.25 to $109.90 a barrel at 1217
GMT. Brent is down for the fourth consecutive week, its longest
weekly losing streak since May 2012.
Platts proposes changes to Brent benchmark
LONDON, Feb 18 (Reuters) – Oil pricing agency Platts has
proposed changes to the way it assesses the Brent oil market
following calls from the industry for a sweeping reform to
improve liquidity and transparency of one of the world's most
important oil benchmarks.
At stake is the credibility of North Sea Brent, the
price-setter for billions of dollars of daily trade in crude.
The benchmark is based on the dwindling supply of four North Sea
crude grades, which critics say makes it prone to manipulation
and can lead to higher oil prices.
Europe's surviving gasoline-focused refineries get late boost
LONDON, Feb 4 (Reuters) – A rush by Europe's refiners to
switch to making diesel may have gone too far too fast, meaning
the remaining gasoline-focused plants can prolong their lives by
supplying rapidly growing Latin American and African markets.
As gasoline consumption has declined in Europe and the
United States, refiners have been investing heavily in diesel
production and closing gasoline units.
Oil refinery work may curb Forties flow to S.Korea
LONDON, Jan 31 (Reuters) – North Sea Forties oil exports to
South Korea, a specialised trade that has supported crude
prices, may drop in coming weeks due to maintenance at
refineries, potentially weakening a source of support for Brent
oil prices.
The flows – a result of a trade pact with the European Union
- became a common feature of the North Sea market in 2012 and
often support prices since Forties is part of the Brent oil
IKEN Capital rolls out high-performing commodity fund
LONDON, Jan 30 (Reuters) – Commodity funds have mostly been
a graveyard for investment returns since 2009, yet London-based
asset manager IKEN Capital's new fund has bucked the trend in
its first six months.
Using a combination of algorithmic and relative value
strategies while hedging out macroeconomic risk, the Commodity
Alpha Fund is up over 7 percent since its "soft" launch in June
2012, having navigated tricky third and fourth quarters in which
many commodity funds were hard hit.
Oil holds above $112 on upbeat China PMI data
LONDON, Jan 24 (Reuters) – Brent crude oil prices held above
$112 a barrel on Thursday, supported by upbeat manufacturing
data from China and Germany, but U.S. crude stocks remained in
focus after capacity in the Seaway pipeline was reduced.
Brent crude futures for March delivery were down 18
cents at $112.62 a barrel by 0939 GMT, underpinned by positive
economic activity data from China and the eurozone. A stronger
dollar was applying downward pressure to offset this.
Top commodity managers tip metals for Q1 on Chinese recovery
LONDON, Jan 21 (Reuters) – Commodity fund managers who
performed well over the testing final quarter of 2012 believe
metals commodities prices could do better than expected in early
2013 due to a combination of Chinese restocking and continued
supply disruption.
Managers at Vescore, Investec and BasInvest, who were
amongst the few to make money in the fourth quarter, are
relatively optimistic about the outlook for commodities going
into 2013, tipping copper, platinum and palladium.

subset: commoncrawl


text:
People tend to check in during these times:
Add hours
Great venue for a game
NH Fisher Cats: Best NH Sports Team (Best of NH 2015, NH Magazine)
Grate Family time.
Grill and pub in left feild.
Not bad seats!
Amazing time
Great game last night the odor wafting up from the river was less than desirable
Stadium was awesome im a fan!!!
Great time
Henderson Alvarez, who has a no-hitter on his MLB resume, began his pro career in the minors at 17 years old. Alvarez blossomed as a 21-year-old Fisher Cat, earning All-Star honors with a 2.86 ERA.
Stay for the fireworks after the game! They were constantly shooting fireworks for what felt like 7-10 minutes!
Fun with friends
Beautiful park.
If you attend a game and don't have the mac and cheese bites, you're missing out!
i worked here when i was a kid
Get here early. We didn't, and I had to park FAR AWAY. There is a shuttle that runs from about a mile away to the park. Food lines are very slow, too. Not as pleasant as in Portland, Me.
Good fun for the family - ten dollar tickets second row from field - dugout right next to you!!
Don't try to park close by for $10, there is free or cheap $1 parking on the streets
Located on the banks of the Merrimack River, Northeast Delta Dental Stadium is the 6,500 seat home of the double-A affiliate of the Toronto Blue Jays 'New Hampshire Fisher Cats.' Always a great game!
Watch for the resident skunk to visit during the game ~ usually in the outfield aeound 9:30 PM or later
Best entertainment value in Manchester. However the beers at the Sam Adams pub are quite pricey. Read more
The ballpark formerly known as Merchantsauto.com Stadium. What shall we nickname it now? "The Tooth"?
View by home plate is great! Weather is warm and game is a close one!
Go to Operation: Thank You! On August 15! Big Meat House cookout (AYCE) @ the stadium! Whoop!
Home of the New Hampshire Fisher Cats Read more
Don't pay $10 for parking. Park at a meter on the surrounding streets for much less. You only have to pay until 8 pm. Sat & Sun are free except in the areas designated with Event Parking signs and the
Pay $10 and get a parking spot right at the front gate...same price as they charge on the street and so much more convenient!
The best kiosk to get food is one of the first when you enter. The sign this year says D'Angelos. The Steak & Cheese is very good but this is where you want to get your burgers, sausage, and dogs too.
Hang at the Sam Adams Lounge. Cold out!
Let's swarm!!
There's nothing like a night out at the ballpark. Read more
this is NOT the official foursquare location for the Fisher Cats
Hoping the rain holds off so the Fisher Cats can play.
Black + Tans are the beer of the night
Fisher Cats Opening Night. You'll find me four rows behind the home dugout toward home plate. Come say hi -- and bring a beer with you -- I prefer the microbrews or a Guinness.
Opening night 4/15 6:35 pm. Will be behind the home dugout. Come buy me a beer.
Get to a game early to get picked for one of the on-field promotions.
Check into NH Fisher Cats on Friday April 16th, 2010 for Foursquare Day in Manchester and receive a buy one ticket get one free offer! Read more
Excellent food and beer selection here. Try the food at the Sam Adams Bar & Grill; it is excellent. Lots of craft brews on tap throughout the ballpark.


text:
United Airlines To Close Cleveland Hub
Company officials say the hub hasn't turned a profit in more than a decade and loses tens of millions of dollars annually. Daily departures are expected to shrink by 60 percent by early summer.
NPR's business news starts with a Cleveland hub closure.
INSKEEP: United Airlines announced plans over the weekend to drop Cleveland Hopkins International Airport as one of its main hubs for connecting flights. Company officials say the hub has not turned a profit in more than a decade and loses tens of millions of dollars annually. How is that possible? It's one of the few airports I can remember where you can get a boilermaker.
Anyway, daily departures are expected to shrink by 60 percent by early summer. United says the decline in flights will force layoffs. More than 470 jobs will be cut at the airport.
Copyright © 2014 NPR. All rights reserved. Visit our website terms of use and permissions pages at www.npr.org for further information.
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text:
ha, try being a brown female. tons more personal emails, tons more requests for photos or worse. almost all of it courtesy of non-western males :S
Razib KhanShared publicly -
people ask me semi-personal things via facebook and email a lot in terms of what i don't say about myself. this is especially common for non-westerners for some reasons (their names and usage of english obvious indicators). i know people are curious, it's human nature. but if i omit, it's cuz it's none of your business. though the few readers of my weblog that i've met are strangely always shocked when i mention stuff which has never shown up on the internet in regards to my life.
9 comments
Gordon Wells
This is only an observation of one, but I feel the design of facebook encourages this. I think displaying every minor interaction with others encourages a level and kind of openness that is unhealthy. You can tidy up your end, but for the most part the environment is the same.
I never get asked random personal questions by strangers, but I do get hit on. Go figure.
Razib, I figured as much. But on most people's walls every previous interaction is recorded by default (I believe this has been replaced by the ticker now). I think this creates/nurses certain expectations.
Randall, I suspect that we will eventually. Just as regional differences are present in the US but slowly are converging.


text:
- 225Promote
Phone Cases
Wild 3 - by Eric Fan and Garima Dhawanby Eric Fan
Protect your iPhone with a one-piece, impact resistant, flexible plastic hard case featuring an extremely slim profile. Simply snap the case onto your iPhone for solid protection and direct access to all device features.
Beautiful serie ♥♥♥
Great working with you Eric! Thank you for a beautiful collab!
Gorgeous work from both artists!
Thanks so much Magdalla, Alexandra and Morgan!
Thank you Garima, likewise! Garima's can be found here: http://society6.com/garimadhawan/Wild...
Thank you Garima, likewise! Garima's can be found here: http://society6.com/garimadhawan/Wild...
So beautiful!
Thanks so much Tummeow, Lisa, Joseph, Trevor, and JUSTART!
you are such a great team!
Thank you so much Chalermphol and Monika!
great collab, again!
Bloody Brilliant!
great work!!
beautiful work, guys!
Thanks for the kind words Paula, Shane, Louise, and Jacqueline! :)
Great work, Eric!~
Love this!
Thanks so much Paula, EbiEmporium, and Creative Chaos!
Gorgeous! :)
See More Comments


text: Fifth Harmony - "Hero" by Hilton Hater at November 15, 2012 7:36 am. Comments Fifth Harmony goes Mariah Carey on us here. Are you down with the group's take on "Hero?" This video is no longer available. Please check below for related videos. Edit Delete Follow The X Factor? Facebook Disqus Tag: The X Factor Related Videos: The X Factor Videos Related Post: The X Factor Top 12: Grouped Together Uploaded by: Hilton Hater Uploaded: November 15, 2012 Duration: 122 seconds


text:
Tony Awards Party To Benefit Magnolia Arts Center
Updated: 06/07/2010 - Magnolia Arts Center presents a Tony Awards party Sunday June 13th at Chefs 505 in Greenville.
Updated: 06/07/2010 - Magnolia Arts Center presents a Tony Awards party Sunday June 13th at Chefs 505 in Greenville.
Updated: 06/07/2010 - It happened Monday morning around 9:30 a.m. when an 18-wheeler broke a valve off its fuel tank, spilling diesel onto the highway.
Updated: 02/08/2011 - The Pitt County man accused of shooting his fiance and burning her body in the backyard of his home in Stokes was scheduled to head to court Monday morning for a bond hearing.
Updated: 06/07/2010 - The Highway Patrol wants to remind all teenage drivers to be aware of the dangers of driving while on summer break.
Updated: 06/23/2010 - The NAACP says it will hold a civil rights forum in wake of last weekend's arrest of Greenville city councilwoman Kandie Smith.
Posted: 06/06/2010 - The totals are in from this weekend's Children's Miracle Network Telethon and $1,111,007 was raised.
Updated: 06/05/2010 - Craig Goess Jr. took the lead in the Messina Wildlife Animal Stopper 200, and held the point on the race's final restart to grab a victory in the ARCA Racing Series.
Updated: 06/05/2010 - A motorist was hit by gunfire while driving in Greenville late Friday afternoon and ended up crashing his car.
Updated: 06/04/2010 - A sign hanging on the entrance to the Mayflower in Winterville warns customers oysters are no longer on the menu.
Updated: 06/04/2010 - One Raleigh man has a plan to contain the oil in the Gulf it and a farm in Pitt County is helping.
Posted: 06/04/2010 - Genell Streeter was last seen on West Third Street and was wearing gray pants, a gray shirts and white tennis shoes.
Updated: 06/03/2010 - It says the program is called "Health Cents". Workers say every time a city or Greenville Utilities Employee works out, they earn health cents, or points, which can be traded in for prizes like t-shirts, gym bags or gift certificates.
Updated: 06/03/2010 - Officials with the Pitt County Board of Elections say they expect a low voter turnout because there are no local races, only the U.S. Senate runoff between Elaine Marshall and Cal Cunningham.
Updated: 06/03/2010 - Three men have been charged and Pitt County deputies are still looking for a fourth suspect after making the discovery Wednesday.
Posted: 06/03/2010 - Fred Applin, Ann Hancock, Shay Hayes and Carol Sciaretta have all been named to the East Carolina women's basketball staff.
Updated: 06/02/2010 - An ECU student and a former football player is out of jail after being tazed by deputies in New Hanover County this past weekend. Deputies say Matthew Pick was running naked down a crowded street.
Updated: 06/02/2010 - At 7 years old, this Aussie-Shepherd Mix had a wonderful life, until her owner passed away--leaving her homeless.
Posted: 06/01/2010 - Tuition could go up by $300.00 for in state students, $750.000 for out of state students at ECU.
Updated: 06/01/2010 - As state universities continue to deal with the budget shortfalls, the question now, is how will tuition rates be affected by it?
Updated: 06/01/2010 - Members of the Civil Air Patrol hope to establish a new squadron in Greenville.
Updated: 06/01/2010 - The man authorities have been searching for since Sunday morning, is now in police custody.
Updated: 05/31/2010 - Monday, Eastern Carolinians took time out to remember service men and woman who have died in the line of duty. This Memorial Day our area was scattered with services commemorating those fallen heroes.
Updated: 06/01/2010 - At Farmville Middle School in Pitt County, almost half of the students didn't show up for class on Memorial Day. Those that did learned lessons on Memorial Day and had a picnic on the school lawn.
Updated: 05/30/2010 - Some people in Greenville say they are fed up with the violence in their neighborhood, and they want it to stop. So they led a meeting this afternoon to talk about what they can do to cut down on crime in their neighborhood.
Updated: 05/28/2010 - Greenville police say they've busted up a burglary ring with three arrests.


text:
about me
To RSVP or not to RSVP, that is the question...
I am understanding, a good listener, cheeky, talkative, compassionate and very caring.
I am fortunate to have an amazing family and wonderful friends, who are all very important to me.
I have a busy and rewarding career, which I love and was born to do...however, I believe balance is key and I live by the mantra that one must "work to live" and not "live to work". I am physically active during the week and keep fit by doing TRX training and doing fun things at the beach on the weekend.
I am a very typical girl in the sense that I love getting dressed up for a night on the town...however, I also love a great conversation about anything and everything.
Love a man who is willing to take control...some of the time ;)
At a glance
|Egb81's details
|Egb81's ideal partner
|34 years old
|33 - 50 yrs old
Sydney City, NSW
(Bondi Beach)
|Within 100km of her
|Body type
|Average, Athletic, Slim
|5'9/175 cm
|at least 6'0/183 cm
|Smoking habits
|Don't smoke
|Don't smoke, Trying to quit, Occasionally / socially
|Relationship status
|Separated, Divorced, Single, Widowed
|Have children
|No, have no children
|No, have no children, Yes, have children living at home, Yes, have children living at home sometimes, Yes, have children who don't live at home
|Wants children
|Want (more) children of my own
|Want (more) children of my own, Undecided
|Very Social, Private, Average, Social
|Eye colour
|Blue, Brown, Black, Grey, Hazel, Other, Green
|Hair colour
|Dark Brown
|Black, Bald, Grey, Other, Blonde, White, Auburn, Dark Brown, Red, Light Brown
|Ethnic/cultural background
|Mixed Race
|Political persuasion
|No strong beliefs
|Sign of the Zodiac
|Gemini Check compatibility »
|Drinking habits
|Occasionally / socially
|Often, Non-drinker, Occasionally / socially
|No special diet
|Have pets
|No, like pets but do not have any
|Yes, have pets, No, No, like pets but do not have any
|Education level
|Post Graduate
|Post Graduate, Degree, Some college, High School, Diploma
|Job role
What I'm looking for
Someone fun, talkative, intelligent, insightful, cheeky, down to earth and an all round good guy.
- Male, for a relationship or dating
My interests
- Music
- I love Roy Orbison, Amy Winehouse, Sia, Bueno Vista Social Club, The Black Keys, Foo Fighters, Muse, Live, Nirvana, Metallica, Kate Bush, Gotye, Stone Temple Pilots, Soundgarden, Faith No More, Nine Inch Nails, Hilltop Hoods, The Ramones, David Bowie, Fleetwood Mac, WuTang, Moloko, Daft Punk
- Reading
- I am an avid reader. My all time favorites include Wuthering Heights, Shantaram and Marching Powder.
- Movies & TV
- Don't really watch much TV but when I do, I enjoy Q&A, Four Corners etc...
- Sport
- Skiing, hockey, soccer, horse riding, ice skating, salsa and anything that takes place at the beach
- Other Interests
- Being ridiculous
My groups
Contact Egb81
- Send a kiss to flirt and see if there is an initial attraction
- Open up a 30-day contact period* to send unlimited messages
- During the contact period you can also chat if Egb81 is online now.
- Get to know Egb81 safely and securely before you exchange your personal contact details
* One RSVP stamp is required per contact period.
- Last online:
- 04 Oct '15


text:
Credits & Info
- Uploaded
- Jan 22, 2012 | 11:42 PM EST
- Weekly Users' Choice January 25, 2012
- Review Crew Pick January 25, 2012
- Daily Feature January 24, 2012
If you liked this, check these out!
Author Comments
Rated 5 / 5 stars
Burrito tiem!
That statement at the end made me choke on laughter.
Rated 4.5 / 5 stars
Nice work!
I really liked this animation because it's funny and the ironic end! You did everything by yourself? Wow, that is awesome!
Just keep up the good work!
Rated 5 / 5 stars
That was unexpected
I loved every part of your animation. Funny ending.
Rated 5 / 5 stars
Excellently done!
I believe this is the first of your flash animations that I've seen, I'll definitely have to keep my eye open for more.
Rated 5 / 5 stars
I love that the sign actually says "Like The Fanciest Restaurant In The City".


text:
Eden Antwerp
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Free High-Speed Internet
Travelers also recommend:
TripAdvisor Reviews Eden Antwerp
Travel Blogs from Antwerp
Going home
Today we get up at 4AM. My uncle drives us to Antwerp in Belgium. That's just 40 minutes by car. From Antwerp we take the express bus to Amsterdam airport. We are the only 4 people in the whole bus! That was cool, I could sit all the way at the front.
In Amsterdam airport some of my mom's friends and my oma are waiting to say goodbye to us.
Then we go to the gate and take a big ...
Brussels Part 2
... but either way they were the same price. This seemed odd to us but we wanted fries so we just asked for the wrap. We took our seats and waited for the wraps and when we got them, were so confused because we didn't get fries. Being so hungry we just shrugged it off and said whatever, only to bite into the wraps and realize the fries were INSIDE the wrap! That's why you couldn't get the pita with fries. After the fact it made sense, but nonetheless the ...
Antwerp, Belgium
... watching the Hasidic Jews go about their business, and window-shopping in the diamond district.
Only sour note to the whole experience was that Megan kept stepping in dog poo, and ranting about people picking up after their dogs etc.
Bus to Paris on 28 August, to vote at the Australian ...
Day one in JC's world.....
... on French B roads, they were all hugely enjoyable, nice smooth tarmac and no traffic to deal with. Then hit Belgium and the accompanying traffic and **** poor driving.....and not just from me either.....
So all in all a good day, weather hit 28C so melted a bit in towns but got to see a French Windmill & a Flemish Elephant...the Elephant was a bit of a random thing to find loafing around in a little village, perhaps the circus was in ...
Brussels; beer and waffles!
... equipped kitchen which allows us to cook and refrigerate stuff. The kitchen is also shared amongst two other rooms but as there is no one else here it is pretty much ours!
The only downside to this place is that there is no television in our bedroom so if we want to watch the olympic games we have to go downstairs to a communal lounge area. Other than that, this place is very good! It's comfortable and has a homey feel to it, probably due to the rugs and bric a brac ...


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Overall score
would recommend to a friend.
Reviewer score
Would recommend
Nice choice
This hotel was great for our needs. We wanted to combine some Clearwater Beach time with site seeing and this hotel was convenient to all. The staff, amenities, and interior of the hotel were much better than average. The location was handy, but
not in an attractive part of town. We would stay here again.
It's just a short drive to Tarpon Springs, Clearwater Beach, Dunedin, Honeymoon State Park, airport, and Tampa.
Very Nice Hotel with Spacious Rooms.
Great Location. Friendly Staff. Clean.
Close to a lot of activities.
Great value, good location
Centrally located to drive back into Tampa, along the coast, visit shopping malls and down to St. Petersburg
Prime Outlet Mall worth the drive for selection and savings
Nice place to stay.
Went down for Spring Training baseball. Great location to see the Phillies, easy drive to see Yankees in Tampa.
Hotel is brand new. Free breakfast. Free, easy parking. Short drive to Clearwater Beach-about 5-10 mins. Not too far from
grocery/drug stores such as Publix, CVS, and Walgreens. Not much withing walking distance, but a short drive will get you to stores and restaurants. The location is not in the middle of everything, but is located close enough that a short drive will have you in Clearwater Beach or on HWY 19 and 60.
Breakfast is free and decent, but there are usually long lines and crowded dining areas. About average in my experience with other hotels offering free breakfast.
Large suite rooms with fridge, microwave, sink, dishwasher, king size bed, bath, flat screen tv, couch, desk, and free in room internet. Pretty much all that you can ask for. Overall a great stay.
You will definately benefit from having a rental car. There is not much located within a close walk, but a short drive will get you to stores and other points of interest.
Nice Comfortable Hotel!!
This hotel was at great location to the beach and about 30 minutes from Busch Gardens. This is the perfect place to stay if you are staying for 2 nights or more. For example, they have a service that shops for groceries for you, 2 stovetop
burners, full refrigerator, microwave, full TV room, and 36' HD TV. I will visit the hotel again in the future, it was great!!
Complementary Breakfast!!!!
Great staff, Great Room
We were looking for a comfortable weekend get away and were overwhelmed with the luxury of the room and the staff. It was much better than the beach hotel we had stayed in last year. And the beach and restaurants were only a few minutes away.
Loved it and will return.
Amazingly CLEAN and beautiful!
We were amazed ond releaved at the cleanliness and home ambiance of this hotel. The room was beautiful, new and even the bed and pillows were so crisp, clean and very comfortable. It made me want to stay longer. We did not use the pool because
we wanted to enjoy the beach (5 minute drive). Restaurants and stores near by. I highly recommend it and will definately stay again!
If you are traveling with kids and do not want to spend lots of money, you can get a family meal from a near by restaurant and bring it back to the room which has a dinning table and full kitchen. You can refridgirate leftovers in the fridge.
Beautiful Rooms and great price!!!!
We were down for spring training with the Phillies and wanted a place that was affordable and not far from the beach. As long as you didn't hit traffic, it took no time at all to get to Clearwater Beach. The staff was very helpful when we needed
suggestions for dinner and directions to some nearby places. I've done trips like this before and would definitely go back there again.
If you are looking for crab legs, then Crabby Bill's is your best bet!!!!
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updated 03/09/2011 AT 10:55 AM ET
•originally published 03/09/2011 AT 12:05 AM ET
Charlie Sheen's latest webcast was no laughing matter.
In a nonsensical rant that lasted about eight minutes Tuesday night, Sheen held back all smiles and witty commentary as he continued to bash Two and a Half Men creator Chuck Lorre.
"Hiya, Chuck-E-Cheese-ball," Sheen began, referring to the boss who fired him Monday. "Where ya hidin,' silly clown? Behind your narcissism? Your greed? Your hatred of yourself or women? Which personality are you cowarding beneath for transparent cover? I see you, you little worm."
When it came to addressing getting fired, Sheen was brief, only saying, "What occurred yesterday was completely and entirely illegal To quote my lawyer, '[expletive], [expletive], suck suck.'"


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We spent a week in San Vito Lo Capo. Everything we tasted here was consistently delicious. Warm pistachio cream filled cornetti for breakfast were heavenly. The cannoli & cassata were sublime, not overly sweet, and the owners were wonderful.
What is Certificate of Excellence?
TripAdvisor awards a Certificate of Excellence to accommodations, attractions and restaurants that consistently earn great reviews from travelers.


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You'll be feeling totally cool when you debut this darling, polka-dot top of cherry by Emily and Fin! This hard-to-find British brand garners inspiration from vintage styles infused with a taste of international flair. With its cute cap sleeves, defined waist, and refreshing white print, this top will have you looking sweet and chic. Serve this playful piece with bright-white, cropped pants, lime-green wedges, and bubbly dot earrings, and treat yourself to a delectable look!
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Casa de Playa Condominiums
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Casa de Playa Condominiums Indian Rocks Beach
Travel Blogs from Indian Rocks Beach
Quick stop in Clearwater.
... humid) and we were on the way to Destin which was halfway between Clearwater and New Orleans. It was a 6 hour drive so I wasn't particularly looking forward to it... Clearwater was a great stop, it was fun having the dog and good company in the apartment and the beach was ok. It probably was a bit too touristy for me. A lot of billboards and signs and American chavs possibly. The sea was lovely but the apartment made up for it and at least we got to visit the restaurant ...
Mobile, Tallahassee and Clearwater
... going on but we had all you can eat seafood which was delicious! When then went on to a wildlife park special for its Manatees. It's was really cool and interesting. We got to see hippo, manatees, alligators and lots of cool birds! We arrived in Clearwater and today we went to Busch Gardens which was really cool. We got on most of the rides and saw lots of the animals. We are exhausted now! But on to Orlando tomorrow for universal and Disney! Much love, Ellie and Dan ...
Getting a routine
... a place that has more going on after 5. The south end, Bradenton Beach, has more motels, tourist bars, shops, etc. My guess is there is more going on there in the evening as well. We have been appreciating being able to walk to everything here but we may need to go elsewhere in the evening for some activity. Since it is dark by 6, the beach isn't an option. Shelling here is not Sanibel, but there is always something to find. I found a small, unbroken sand dollar this afternoon. ...
Last Day at Disneyworld
... all these extras. We drove to get our bags at Animal Kingdom Lodge and then drove to Tampa. We got lost and stopped at a shop for Dad to get a sim card for his phone so we could get GPS.
We drove to our hotel at Clearwater Beach and crashed (not the car).
USA Fact: They drive on the wrong side of the road!
Come Sail Away,
Checked out of the hotel and headed to the ship a little before Noon. It was only about 5 min by cab, to the pier. The line to drop your luggage was extremely long, and took us almost 20 min. Then upstairs for a much shorter security line, and no line for Suite Guest check in.
The best benefit of being in a suite was that the room ...
Other places to stay in Indian Rocks Beach
Hamilton House Condominiums1510 Gulf Blvd., Indian Rocks Beach | 4 star condofrom $132


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The hardest thing when starting a WordPress blog is finding the WordPress plugins perfect for you and which ones you simple must have. So, to help you out and get you kickstarted in to the world of WordPress blogging I've shared some of my favourite WordPress plugins and which I think are useful in every day WordPress use.
Essential WordPress Plugins
WordPress SEO by Yoast
Probably the most popular WordPress plugin this is also one of the most useful. This plugin gives you a great post by post SEO section in your WordPress back end to change the title, meta description, focus keyword of the post. It also includes a ranking system of how well your post is optimised for search engines which includes tips on how to make it the best it could possibly be. As well as the everyday use settings such as these mentioned the plugin includes options to change the robots meta configuration, change canonicals, change breadcrumbs, clean up permalinks, create XML sitemaps, RSS enhancements, robots.txt and .htaccess editing, and Twitter cards, Facebook Open Graph and Google+ authorship settings (very useful!). If you were going to install just one plugin on your blog this is the one you need.
Revive Old Post
Do you want to post consistently on social media driving traffic back to your blog? This is a great tool to do just that. Revive Old Post, formerly Tweet Old Post, will schedule a post to be shared via Twitter, Facebook, LinkedIn or Tumblr. The scheduled posts can come from any category on your blog, be scheduled to be posted a number of days after it goes live, have the URL shortened, and has the option to add hashtags or additional text to your message. I personally use this on my WordPress blogs and it is very good at keeping a constant presence on social media and drive traffic back to your site.
Another plugin I use on my websites, MailPoet allows you to build an email newsletter and email address database in the backend of WordPress, awesome right? This has a sister plugin which allows you to create a bar at the top of your page to prompt your readers in to subscribing to your newsletter, once your users enter their email in this will be added directly in to one of your databases in MailPoet ready for sending newsletters to. Another great feature that I love in MailPoet is the fact that it has a built in email newsletter creator. Honestly, it's the easiest thing you've ever done, just click and drag posts in to your email newsletter. Add titles, text, images, dividers, social bookmarks right in to the email or choose from loads of free and premium themes to make your email look incredible. As well as all this you get reports of your sent email in the WordPress back end too. If you're looking for an email newsletter service this is my personal recommendation, I love it.
Authors Widget
If you're running a blog that has multiple contributors and you want to show these in the sidebar with their articles they've written. You cna show your authors in a list, tag cloud or dropdown with the option to have a post count next to their name and avatar. Very practical for multi-author blogs.
Youtube Channel Gallery
If you're running a blog alongside a Youtube channel or you're a Youtuber looking to expand in to owning your own website too this is a great plugin. The Youtube Channel Gallery WordPress plugin creates a feed of your videos and then displays them on your blog front end in a beautiful gallery with a large video player at the top with as many more video thumbnails beneath that as you want. It features a quick set up and beautiful front end display I think this is my favourite Youtube plugin I've seen so far, definitely worth a download if you create content for Youtube.
Used by many big blogs including SocialMediaExaminer this is a plugin that tries to keep your visitors on your site by bringing a pop up to the screen when a users cursor goes towards the top of the page. This pop up should include something like an industry report, free ebook or something that will add value to the customer and not just a simple email sign up form. You can choose from many different animations for when it does pop up, these will be able to help you capture the attention of your readers a little better than a simple block pop up. This plugin is however a paid plugin, with prices starting at $49/year with the most being $199/yr, there is also a monthly payment option.
Social Count Plus
Social proof is a great way of boosting your engagement, if people see you're popular they'll want to get in on the trend early. This plugin has multiple options for how the icons look and are orientated and includes sites such as Twitter, Facebook, Youtube, Google+, Instagram, Steam, Soundcloud, posts and comments. Despite this post being based around WordPress plugins you may want to hold off on this for a couple of months as you build your following on your social platforms; it might work against you showing small numbers of followers, likes and subscribers.
Email marketing is the backbone of online marketing and when you're starting your email marketing campaign you should use email newsletter templates for a quick, professional email newsletter. If you're looking for theme email newsletter templates then you've come to the right place, we've got 7 of our favourite email newsletter templates below. Many of these templates are repsonsive to enable your recipients to view your email on their phone, tablet and PC, which is incredibly important when sending out email newsletters, nothing's worse than a poorly rendered email.
Email Newsletter Templates
Modern Business 3 LIGHT – Email
- 8 Unique Layout Designs
- 8 Unique Color Schemes
- 64 HTML Email Templates
- 7 Layered Photoshop Files
Market – Responsive Newsletter with Template Builder
- 8 Prebuild Layouts
- 24 Color Variations
- 28 different Elements
- 768 HTML Files (inline & embedded CSS)
- 24 Full layered PSD files
- 24 Full layered PNG files (Fireworks)
Versatile Email Newsletter Template 2
- 9 Prebuilt layouts
- Modular layouts
- Layout creation system
Idea Mail – Minimal & Responsive Email Template
- 70 Responsive HTML email templates
- Layered elements PSD files
- Responsive email template based on fluid structure and Media Queries with ability to remove responsiveness
Koble – Responsive Email Template
- 6 color style
- 3 Notification Layout
- Up to 30 Repeatable modules
- 10 Style Layouts
Rich Typography Email Template
- Easily customize your own layout and colors with built-in layout elements – just copy and paste
- Both light and dark versions
- 5 professional layouts for each version
- Image-blocker friendly. Does not rely on images for graphical style!
- Includes customizable css and launchable inline css files for every layout
BlauMail – Responsive Newsletter
- 5 Color styles
- 3 Backgrounds
When creating your new website the easiest way of creating a website is by creating a static HTML website. If you're looking to quickly get online learning HTML isn't the quickest or easiest option. So you need a HTML website template. Here's a list of 5 of the most popular HTML website templates. Quickly get online with these premium html website templates using the oldest coding language used on the web today, HTML. This is the basic coding language for websites. These HTML website templates below are designed to be implemented in to a CMS but can be used as a standalone website. I would recommend using them as a standalone only if your website content doesn't change that often.
Canvas | The Multi-Purpose HTML5 Website Templates
- 450+ files included
- Parallex scrolling + HTML5 Videos
- 7 sliders with 20+ templates
- 50+ scalable shortcodes
- eCommerce ready
Porto – Responsive HTML5 Website Template
- 55+ HTML Files
- Twitter & Flickr Feeds
- Grid System and Responsive Design
- Style Switcher & CSS Generator
- Working Newsletter (MailChimp Signup Form Only)
Linstar – Responsive MultiPurpose HTML Website Templates
- 100+ Page Templates
- Unique Page Layouts
- Background Videos
- Unlimited Colors & Patterns
- Responsive Design
Rhythm – Multipurpose One/Multi Page Template
- 130+ HTML Files
- Light, Dark and Transparent Menu Bars
- Easy to customize: backgrounds, color schemes, content
- Responsive video
- Fully responsive
BuildPress – Construction Business HTML Website Template
- 20 Pages
- Pricing Tables
- Boxed and Wide layouts
- Testimonials Slider
- Working Contact Form
At the heart of any good business is a good business card. But, who wants to pay for someone to design a business card for a couple of hundred pounds when you can get a free business card template online? I certainly wouldn't. We've collated a large list of 10 free business card templates that you can use. This includes a wood style business card template, a transparent business card template and a cool retro business card template. Choose your favourite, download the free PSD and then comment below which of these free business card templates your favourite is.
Colorful Flat Business Card Template
Business Card Mock-up Template
Free Retro Print Toolkit v.1
Business Card Mockup Freebie
Retro Wooden Business Card
Business card mockup
Creative Ring Business Cards
PSD Transparent Plastic Business Card
Colorful Line Business Card Template
Psd Business Card Mock-Up Vol22
If you liked these free business card templates, comment below and show your appriciation with a share. For more awesome content like this, sign up to our newsletter using the bar at the top of the window, or follow me on twitter @AdmStevens where I post links from all around the web including the best web and graphic design links.
The LandX template is a free PSD template with a paid HTML version available. This free PSD template allows you to set up a beautiful landing page or website for your business.
Format: Layered PSD
Vector Shapes: Yes
Dimensions: 1920×7108 px
Size: 11.3 Mb
Infographics have grown in popularity and are great for getting your business a lot of exposure and links back to your website, but they can take quite a while to produce. These four infographic templates give you an easy way to create multiple infographics in a short space of time thus giving you a greater ROI. Each infographic template will give you four sections that you can enter text and information in to portray in a nice visual manner.
Modern Infographic Template (2 Items)
4 in 1 Business Infographics Bundle
4 in 1 Business Infographics Bundle
4 in 1 Business Infographics Bundle
This ceramic bottle free PSD mockup comes from Graphic Burger. Easily integrate your design with this mockup by using the in built smart objects to insert your design and see it crafted on to a ceramic bottle instantly. Wow CEOs, potential business partners and buyers with a great design on a photorealistic bottle, making it easy to visualise your product. Perfect for pitching new ideas and getting your ideas down on paper this free PSD mockup file is perfect for the start up business looking to bring a product to market.
Format: Layered PSD
Smart Objects: Yes
Dimensions: 3000×2000 px
Minimum Photoshop Version: CS4
Size: 15.9 Mb
We love minimal and the minimalistic design style. We've collated a list of 11 minimal WordPress themes that look absolutely amazing in any browser. Tell us in the comments which is your favourite out of these 11 minimal WordPress themes.
Bloc – Minimal Portfolio Theme
Fully responsive, ecommerce ready and comes with easy theme options editor.
UBER – Minimal Multi-Concept WordPress Theme
Drag and drop page builder, fully responsive, beautiful minimal design.
Minimal – Multipurpose Minimal WordPress Theme
Easy to use theme options editor, video tutorials for easy set up and install, fully responsive, plus many premium plugins included.
SEVEN – Minimal Portfolio / Agency WordPress Theme
Drag and drop page builder, fully responsive, retina ready, image based minimal WordPress theme.
MAMA – Creative Minimal Portfolio WordPress Theme
Fully responsive, retina ready and full screen image capabilities, perfect for a personal portfolio.
The Reader WordPress Minimal Blog Template
Familiar design, fully responsive, easy to use theme options editor makes The Reader a beautiful minimal WordPress theme.
March – Minimal Portfolio & Blog theme
Clean, responsive and easy to set up this portfolio and blog WordPress theme focuses on showing content in an amazing fashion.
Raiden – A Minimal WordPress Theme with Style
Retina ready, fully responsive and with an easy to use theme options editor this personal portfolio blog WordPress theme also comes with custom widgets.
Fulgor – Minimal Fashion eCommerce WordPress Theme
Fully integrated with WooCommerce to create a beautiful online store with a responsive, retina ready minimal design and a stunning set of different home pages among many other features.
Omega – Minimal WordPress Theme
Fully responsive design with a powerful admin editor this minimal WordPress theme comes with a quick set up guide video tutorial plus many more features.
Super Skeleton WP: Responsive, Minimal, Beautiful
Fully responsive, this theme uses the super skeleton UI to create a lovely minimal design, this also comes with 20 free HTML template files to show just what the UI can do.
Need a free WordPress theme? Well, we've got six of the best for you to choose from. From photography WordPress themes to beautiful magazine WordPress themes this list has it all. Choose your next free WordPress theme below and in the comments tell me which of these free WordPress themes is your favourite.
SKT Photo Session
Creator: SKT Themes
This is a Photography-oriented free wordpress theme that includes a beautiful home page slider with a lot of user-friendly customization such as a responsive design, integrated social media and has easy to use theme options in the admin panel.
Karo Light Magazine Theme
Creator: Kopa Theme
The image above does not do this theme justice. With multiple sidebars and layouts including a huge featured posts slider this theme has everything you could want when setting up your online magazine. Social links, responsive design and easy shop integration.
Photoshoot Theme
Creator: Faster Themes
This free Wordpres theme is the one for Photographers. It is perfect for images and albums, with a responsive design, social links integration and also has a paid version. A clean design showcasing your images as soon as you hit the homepage with a large slider and multiple photos below that, if you're looking for a free photography WordPress theme look no further.
Creator: Automattic
A clean, minimalistic design, this theme relies heavily on images. With a single column, distraction-free layout this is a great website for a content rich website featuring elegant typography. The demo doesn't do this theme justice, it doesn't show you the posts with images, which in my mind is what makes this theme amazing.
Creative WordPress Theme
Creator: ThemeShock
With a beautiful hand-drawn background this theme is completely responsive and highly customizable. This is a social media integrated responsive design that is perfect for kick starting any blog. Choose from four different sliders, 1000+ GUI elements and tons of custom layouts to make this free WordPress theme your own.
Portfolio Blog Responsive Theme
Creator: Dessign
Customizable colors, responsive design and large image slider makes this theme one of our favourites. The homepage design is simple yet elegant, it gives a high level of usability while still looking amazing. If you're new to WordPress and want a different, easy to implement and beautiful theme this is the one for you.


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Click Here for 2016 Season Info
Women's Fellowship Dinner - Monday, August 31, 6:30pm, Fellowship Hall
Women of ALL ages are invited to this event! Join us for an evening of good food and great fellowship. Janet Grant will do a devotional, and attendees will have an opportunity to hear about the classes, groups, and retreats that are planned for women this fall/winter. Cost of the dinner is $6.00, and reservations are a must! Call Debbie Ferrugio at 793-5712, ext. 13 if you wish to attend.
Ruth Circle - Resumes Tuesday, September 8, 10:30am, Room 106.
Due to Labor Day, the Ruth Circle will resume on Tuesday, September 8. Normally this group meets on the first Monday of each month. These retired women invite anyone who is looking for a UMW small group. Their current study is The Upper Room IN SMALL GROUPS.
Building Better Moms - Thursdays, beginning September 10, 9:15am - 11:15am, Room 101.
Co-Leaders: Kelly Hutcheson and Jackie Simpson. Mothers of infants to teens are invited to join BBM as we learn, grow, and serve together. The group meets on six Thursdays before Christmas and six Thursdays after Christmas. Moms may still register for the 2015 - 2016 school year. The registration fee is $40.00 and the childcare fee is $20.00 per child. Registration forms are available in the Church Office or on the table outside Room 109. The forms and fees should be given to Rachel Lever.
Women of Faith Conference - Orlando - September 18 - 19, 2015 - The Farewell Tour.
Contact Rachel Lever at firstname.lastname@example.com or 793-5712, ext. 21 for more information.
Leesburg Women's Retreat - Life Enrichment Center - April 1 - 3, 2016 - Theme: Come, Holy Spirit
Contact Rachel Lever at email@example.com or 793-5712, ext. 21 for more information..


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N'Co. Can't Get Enough Of Me. This large filly should mature out around 15 hands plus. Sweet as can be and tons of breed type$10,000
Justie is going to be a big boy. Both sire and dam over 15 hands. Justie is very heavy in the hip and gorgeous big front already exhibiting a lot of…$10,000
Iron Wolf is out of Imported Revised PRE Andalusian Stallion WOLF and PRE Andalusian mare Algeria de Fandango. Both of which are champions in the show…$10,000
12 year old tennessee walker/quarter horse. Smooth gait, nice trail riding gelding. Stocky with small head. Loads great, stands for farrier, easy keeper…$2,000
"Indy" was born 4th of July of 2014 He is out of imported, revised PRE Andalusian Stallion WOLF and Quarter horse mare Dun it in Wisconsin, who's grandsire…$5,000
Mr. Loud is truly one in a million! Raise right & trained by professionals. Mr. Loud loves to trail ride, will do fabulous in horse shows. Rides indoor…$7,500
Beautiful elegant mover with a lovely personality. Currently eventing with a junior but would excel in dressage. Has some basic second/third level movements…$12,000
Dakota is an AMAZING well trained spotted saddle horse mare, black and white, 14.3h, 10 yrs old and she neck reins. The is very well TRAINED and has always…$1


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Land Rover Repair in Powell
Our master mechanics identify the best Land Rover repair shops in Powell. Edit search×
- Early Bird Dropoff
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Real Customer Review(s)
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Real Customer Review(s)
Our goal is to offer the best services available at affordable prices to get you back on the road in no time.
Shifflet Auto Care Center You'll be hard-pressed to find the same level of expertise that our auto mechanic specialists provide! We have years of experience working on both domestic and import vehicles of all makes and models and can work with you to find cost-effective repair and maintenance alternatives.
For a high-performing vehicle, trust Shifflet Auto Care Center with your car, truck, or van. To learn more about the services we offer, please contact us by phone at 614-488-9951 or send us an email. We also invite you to learn more about our dedication to you, our valued customer.
There are 25 Land Rover service shops and mechanics in Powell. Edit searchSee other Land Rover repair shops and dealerships
RepairPal has not certified the following shops.
The shops listed below are not committed to the fair price guarantee and minimum warranty of RepairPal Certified shops. When taking your car to a shop that has not passed RepairPal's inspection, we recommend that you:
- Look for a shop with ASE-certified technicians.
- Request written estimates from multiple shops and check them with the RepairPal estimator
- Verify that the shop you select is willing and able to clearly explain the work being performed.
Land Rover repair shops and dealerships near Powell.
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"An exceptional shop, outstanding service by knowledgeable staff. They went above and beyond in addressing a complex ..."
"I've only been there once, but I am considering moving all of my repair / maintenance work there. I have heard good t..."
"Love this shop! They're honest, good, and reasonably priced."
"Incompetent counter people Jennifer and Ron that don't know what they are talking about--very disrespectful when talk..."
"Not trustworthy..think twice taking the car to this location .
Take it to Tansky if you like dealer location or Hi..."