text:
|Publication number
|Publication type
|Application number
|Publication date
|Jan 18, 2005
|Filing date
|Apr 18, 2001
|Priority date
|Jun 16, 1997
|Fee status
|Also published as
|Publication number
|Joseph Gross, Gilad Lavi, Izrail Tsals
|Original Assignee
|Elan Pharma International Limited
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (43), Referenced by (38), Classifications (28), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a Divisional application of, and claims priority under 35 U.S.C. �121 to, A.S.N. Ser. No. 09/103,716 (now U.S. Pat. No. 6,500,150), filed on Jun. 23, 1998 which in turn claims priority under 35 U.S.C. � 119 (e) of provisional patent A.S.N. 60/093,062 having a filing date of Jun. 24, 1997 which in turn was converted from utility A.S.N. Ser. No. 08/881,542 filed on Jun. 24, 1997 which in turn claimed priority under 35 U.S.C. � 119(a)-(d) of Irish Patent Application No. 970445 filed on Jun. 16, 1997.
This invention relates to pre-filled drug delivery devices, and in particular to devices for attachment to the skin of a subject having a needle for penetration of the skin of the subject.
WO 97/21457, which is incorporated herein by reference, discloses a liquid drug delivery device having a base member defining a skin-contacting surface for application to the skin of a subject. A columnar cartridge serving as a reservoir for the drug is connected to the base member such that in use the longitudinal axis of the cartridge is disposed substantially parallel to the skin-contacting surface. A delivery needle communicates in use with the interior of the cartridge and is adapted to penetrate the skin of the subject, and there is provided means for expelling a drug out of the interior of the cartridge and through the skin of the subject via the delivery needle.
It has been found that adapting conventional cartridges (such as cartridges for pen-type insulin injectors, or other drug cartridges well known in the art) so as to enable an expelling means to expel the drug therefrom, and so as to enable communication with a delivery needle forming part of such a device, increases the costs of the cartridge considerably, and this in turn adds to the cost of the overall device and hence its attractiveness to consumers. The main reason for this is that conventional drug cartridges are relatively inexpensive, but redesigning such a component and changing the manufacturing process, or individually modifying such components drives costs up considerably.
Nevertheless, in technical terms, the devices of WO 97/21457 have undoubted advantages over the prior art due to the fact that the disposition of the cartridge parallel to the skin enables the device to be applied to the skin and worn unobtrusively during drug delivery. Both application of the device and delivery of the drug can be accomplished in a single step requiring little or no manual dexterity.
A further problem associated with the devices of WO 97/21457 is in relation to the delivery needle which effectively extends at right angles to the axis of the cartridge. This may be accomplished by using a conduit arrangement leading from the cartridge to a conventional needle, or by means of a right-angled needle which extends from an end of the cartridge co-axially with the axis of the cartridge and then bends through a right angle to penetrate the skin. The latter arrangement is preferred since it reduces the number of parts and the complexity of the device. However, it may prove difficult to bend a needle while maintaining sterility (which is of course essential), since the sterility of the needle is assured by a protective sheath which extends the entire length of the needle and which may be damaged in the bending process.
For devices which employ a needle to penetrate the skin there is a danger that after use the device may accidentally infect the patient or others if not properly disposed of. Our WO 95/13838 discloses an intradermal device of this type having a displaceable cover which is moved between a first position in which the needle is retracted before use and a second position in which the needle is exposed during use. Removal of the device from the skin causes the cover to return to the first position in which the needle is again retracted before disposal.
The present invention aims to decrease the possibilities that the needle could become exposed by accident before or after use for example by a child playing with the device if not properly disposed of. Clearly given the risks associated with infectious diseases, particularly those carried by blood, any possibility of accidental infection must be minimised to the utmost and preferably eliminated entirely.
Some of the features of devices according to the invention which address these problems are set out below, and further advantages will become apparent from the following description.
In devices of the present invention, a conventional syringe barrel is mounted relative to a base member defining a skin-contacting surface, with the longitudinal axis of the needle substantially parallel to the skin-contacting surface in use.
The invention provides a base member defining a skin-contacting surface for application to the skin of a subject;
Preferably, the syringe is a pre-filled syringe.
By employing a conventional syringe, preferably a pre-filled syringe, the devices of the present invention avoid the need for custom-designed components for which it may be difficult to obtain regulatory approval and manufacturing validation from bodies such as the U.S. Food and Drug Administration (F.D.A.) and similar other national bodies.
It has been found that while conventional drug-containing components such as cartridges and pre-filled syringes are relatively inexpensive, redesigning such components and changing the manufacturing process, or individually modifying such components drives costs up considerably for the device as a whole, which decreases the attractiveness of such devices to customers. Thus, devices of the present invention which employ widely available syringe bodies will be advantageous over corresponding devices which include a non-standard drug chamber.
Preferably, a mounting member is mounted along the length of the exterior of the needle at the angled portion. Such a mounting member serves two purposes: firstly it acts as a mounting point for a seal or sheath to ensure sterility of the portion of the needle which will contact or penetrate the skin, and secondly it may assist in the correct bending of the needle during the manufacturing process.
Preferably, the mounting member is permanently affixed to the needle.
Further, preferably, a sealing sheath is mounted on the mounting member.
The sheath is preferably removably mounted on the mounting member.
Preferably, means are provided for driving a piston along the interior of the syringe barrel, and these means are also mounted relative to the skin-contacting surface. Preferably, both the syringe barrel and the driving means are mounted within a housing.
In preferred embodiments, the driving means is disposed alongside the syringe barrel rather than at the end thereof, as this arrangement may lead to a more ergonomic design, as well as to advantages in the manner in which the driving means may be actuated as will be explained below in greater detail.
Preferably, the driving means is a gas generator.
Suitably, a tube provides communication between the gas generator and a piston in the syringe.
In one embodiment, the needle extends from the neck of the syringe barrel parallel to the longitudinal axis of the syringe and then bends to a substantially right angle, such that the tip of the needle points perpendicularly to the longitudinal axis of the syringe.
Preferably, the sealing sheath is provided with a flexible pull tab which extends through a release liner.
Further, preferably, when the pull tab is pulled away from the base member, the release liner is pulled away from a lower surface of the base member and the sealing sheath is detached from the mounting member to reveal the needle tip.
In one embodiment, the base member is pivotally mounted to a housing of the device.
Preferably, the device is provided with a removable locking member such as a semi-rigid safety tab which prevents relative movement of the base member towards the housing following removal of the sealing sheath and the release liner, thereby retaining the needle within the housing until skin penetration is required.
Further, preferably, relative motion of the housing towards the base member causes activation of the gas generator while optionally simultaneously causing the needle tip to penetrate the skin.
Preferably, the base member is displaceable relative to the housing between a first position in which the needle is concealed from the exterior of the device and a second position in which the delivery needle protrudes from the device for penetration of the skin, the device further comprising means for locking the device in the first position after a single reciprocation of the device from the first position to the second position and back to the first position.
In this embodiment preferably the locking means comprises a mechanical latch which is brought into operation by said reciprocation.
In an especially preferred embodiment said latch comprises a pair of elements mounted on the base member and the housing respectively, said elements being shaped such that they can have two relative configurations when the base member is in said first position relative to the housing, namely a movable configuration in which the elements are mutually movable, and a locked configuration in which the elements are prevented from mutual movement, and wherein reciprocation of the base member and the housing causes the elements to pass from the first movable configuration, through an intermediate configuration when the base member is in said second position relative to the housing, and then to said locked configuration, thereby preventing any further movement of the base member relative to the housing.
Also preferably one of said elements is provided with a recess which is adapted to receive a projection on the other of said elements, the recess and the projection being spaced apart from one another in the movable configuration, and being in engagement with one another in the locked configuration.
Further, preferably, movement of the base member relative to the housing is initially prevented by said removable locking member.
Still further, preferably, the presence of said removable locking member also prevents the means for providing a gas from being actuated.
The removable locking member preferably comprises a laminar member inserted between said base member and said housing.
In a preferred embodiment following delivery of drug through the needle, any residual gas is vented through a release valve.
In one embodiment means are provided for enabling a user to determine that delivery of drug has been completed.
In a further embodiment, the syringe barrel is provided with an end piston in addition to an internal piston so as to allow for mixing of a drug in a lyophilised form with a diluent, said internal piston initially dividing the interior of the syringe barrel into a diluent compartment and a drug compartment.
Preferably, the pressure resulting from the gas generator is transmitted through the diluent compartment so as to push the internal piston into the drug compartment allowing for ingress of diluent into said drug compartment.
In a further preferred embodiment a travel limiting mechanism is provided to limit the maximum amount of travel of the internal piston along the length of the syringe barrel so that the dose of drug can be adjusted to suit individual user needs.
It will be appreciated that the locking means described herein is capable of having a broad application in drug delivery devices having a drug delivery needle.
Thus in a further embodiment the invention provides a drug delivery device comprising:
Preferably, the base member is pivotally mounted to the housing.
Preferably, the locking means comprises a mechanical latch which is brought into operation by said reciprocation.
Also preferably, said latch comprises a pair of elements mounted on the base member and the housing respectively, said elements being shaped such that they can have two relative configurations when the base member is in said first position relative to the housing, namely a movable configuration in which the elements are mutually movable, and a locked configuration in which the elements are prevented from mutual movement, and wherein reciprocation of the base member and the housing causes the elements to pass from the first movable configuration, through an intermediate configuration when the base member is in said second position relative to the housing, and then to said locked configuration, thereby preventing any further movement of the base member relative to the housing.
Further, preferably, one of said elements is provided with a recess which is adapted to receive a projection on the other of said elements, the recess and the projection being spaced apart from one another in the movable configuration, and being in engagement with one another in the locked configuration.
Still further, preferably, movement of the base member relative to the housing is initially prevented by said removable locking member.
The invention also includes a method of manufacturing and filling drug delivery devices in which a syringe barrel is filled with a drug under sterile conditions, with the fluid path and the skin-contacting and—penetrating portion of the needle also sealed or sheathed under sterile conditions. After this is completed, the remainder of the manufacturing and assembly steps can be carried out in a clean area (as opposed to a sterile area) since the sealed pre-filled syringe barrel remains sterile.
Thus, the invention provides a method for manufacturing and filling a drug delivery device comprising:
The term "clean area" denotes an area of high cleanliness as would be expected for manufacturing medical devices. The term "sterile area" denotes a higher standard of cleanliness (i.e. sterility) such as is required for areas in which syringes are pre-filled. While medical devices must be assembled in clean areas according to well defined standards, the level of cleanliness is not as stringent as for a filling suite in which parenteral drug containers are filled. By pre-filling and sealing all parts of the fluid path, one obtains a component which can be assembled with other components under normal clean area conditions.
Preferably, the sterility of the drug delivery path and the skin-contacting and skin-penetrating portions of the needle is achieved by securely affixing a mounting member along the exterior length of the needle under sterile conditions.
Further, preferably, the drug delivery path and the skin-contacting and skin-penetrating portions of the needle are sealed by means of a sheath mounted on the mounting member.
Preferably, the external mounting member is used as a bending point when a right-angled needle is required.
The sterility of portion of the needle adjacent the needle tip may be assured by securely affixing a mounting member along the exterior length of the needle and ensuring that the mounting member and needle are sterile, following which a sheath or seal is mounted on the mounting member. Subsequent steps of manufacture can then be carried out on the needle without compromising sterility. For example, the external mounting member can be used as a bending point if a right-angled needle is required.
Because of the difficulties in manipulating axially unsymmetric components on a mass-production line, particularly where an unsymmetric part of the component protrudes sideways from an otherwise regular device (e.g. a syringe barrel with a bent needle extending perpendicularly for skin penetration) it is desirable to bend the needle as late as possible in the assembly process.
Conversely, because the sheath guarantees sterility, it is desirable to sheath the needle as early as possible in the manufacturing process (since remaining steps can be carried out in the less expensive clean area).
However, when a seal or sheath is mounted on the neck of the barrel to cover the needle, it is difficult to bend the needle without damaging the sheath and compromising sterility. Equally, it is difficult to mount a sheath on a bent needle since the manipulation may be difficult and the tip of the needle is likely to damage the sheath. Thus, the use of a sterile sheath and the requirement of a bent needle give rise to a conflict as to the most desirable method of manufacture.
The use of a mounting member solves this problem in two respects. Firstly, it enables the sheath to be applied at an early stage (during the filling of the syringe barrel, for example). The sterile barrel can then be removed from the sterile area for further manufacturing/assembly steps. Secondly, the needle can be bent with the sheath intact without having to contact the sheath and risk damage. The needle can be held by the mounting point and bent, and this step can be carried out in a clean environment without any risk to the sterility of the fluid path or the portion of the needle which penetrates or contacts the skin.
In a further aspect the invention provides a method of delivering drug to a subject comprising the steps of:
Preferably, the tip of the delivery needle is substantially perpendicular to the skin contacting surface such that in use the tip of the needle is adapted to penetrate the skin of the subject.
Also preferably, the the means for expelling the drug comprises a gas generator.
Further, preferably, the syringe is prefilled.
Also preferably the device is activated by moving the housing towards the base member.
Preferably, the movement of the housing simultaneously causes the needle to penetrate the skin.
Further, preferably, the method comprises the step of causing the device to lock into position after use whereby the needle tip is recessed within the housing.
Other objects, features and advantages of the present invention will become apparent upon reading the following detailed description of the embodiments of the invention, when taken in conjunction with the drawings and appended claims.
The invention will be further illustrated by the following description of embodiments thereof, given by way of example only with reference to the accompanying drawings.
A gas generator 15 which will be described in greater detail below is mounted in the housing alongside syringe barrel 12, and a tube 16 provides communication between gas generator 15 and piston 14.
A needle 17 is mounted in conventional manner at the neck 18 of syringe barrel 12 to provide a conduit for delivery of drug 13 from syringe barrel 12 under an applied pressure from piston 14.
Referring to
Housing 11 has a base member 22 pivotally mounted thereon at a hinge 23. The lower surface 24 of base member 22 is provided with a contact adhesive layer (not shown) and a release liner 25 covers the lower surface 24 before use.
Protective sealing sheath 21 is provided with a flexible plastics pull tab 26 which extends through release liner 25. When pull tab 26 is pulled away from base member 22 (FIG. 3), release liner 25 is peeled away from lower surface 24 and sealing sheath 21 is detached from mounting member 20 to reveal needle tip 19. Needle tip 19 is still somewhat concealed from full exposure by base member 22 which is hinged away from housing 11.
Following the removal of sealing sheath 21 and release liner 25, the lower surface 24 is applied to the skin to which it adheres. A semi-rigid safety tab 27 prevents relative movement of base member 22 towards housing 11 by passing above a first cylindrical post 28 integral with base member 22 and below a second cylindrical post 29 integral with housing 11. Although first cylindrical post 28 is adapted to fit inside second cylindrical post 29 and thereby allow base member 22 to move towards housing 11 about hinge 23, safety tab 27 prevents this when present.
As will be further explained below, the relative motion of housing 11 towards base member 22 also causes the activation of gas generator 15 (not visible in FIGS. 2-5), and thus at the same moment that needle tip 19 penetrates the subject's skin, the gas generator 15 begins to generate gas, thereby increasing the pressure in tube 16 which in turn causes a driving force to be exerted on piston 14 to drive drug 13 through needle 17 for delivery to the subject. Such delivery is preferably subcutaneous, although it could also be intravenous, intramuscular or intradermal (i.e. to a point within the dermis below the epidermis), depending on the configuration of the needle and the positioning of the device on the skin of the subject.
Syringe barrel 12 is formed of a transparent material and a window 35 in upper surface 30 of housing 11 enables the user to see that delivery has been completed.
The operation of the gas generator 15 will now be described with reference to
As shown in
Because the gas generator 15 is situated alongside syringe barrel 12 rather than at the end thereof, it is further from the hinge 23 than would otherwise be the case. It may be preferred to move the gas generator 15 further from the hinge 23 than is shown in the present embodiment (see FIG. 1). This would mean that the action of pushing housing 11 towards base member 22 (i.e. pivoting housing 11 and base member 22 together about hinge 23) is more effective in causing the penetration of foil membrane 38, since the further the distance a body is from the fulcrum of a lever, the greater the linear movement is for a given angular movement about the fulcrum. For this reason also, the needle 17 can penetrate the skin with a quick painless action because the needle travels in a predominantly vertical fashion which minimises penetration and thus any pain involved therein. If the needle were closer to the hinge, it would travel in a more circular pattern creating a larger pathway upon penetration and consequently cause more pain. A further advantage of moving gas generator 15 away from hinge 23 results from the fact that the citric acid 37 and sodium bicarbonate 40 are mixed to a greater extent (again due to the higher speed at which the foil membrane 38 is penetrated), and gas generation is thereby smoother.
Thus, in
As shown in
As previously indicated, the invention provides a method of manufacture which utilises a standard hypodermic syringe and which allows a sterile sheathed needle to be bent without risk of compromising the sterility. A method of manufacturing the device of
The assembly shown in
Outside the sterile area, i.e. in a clean room, the tube 16 is mounted on the syringe barrel 12 (see
Referring next to
It can be seen that the design of the device allows the majority of the manufacture and assembly to occur outside a sterile area while still ensuring that those parts of the device for which sterility is required remain sterile.
The barrel 50 is provided with an end piston 51 which is acted on by gas pressure from a gas generator as previously described. An internal piston 52 initially divides the interior of syringe barrel 50 into a diluent compartment 53 and a drug compartment 54. The internal bore of the syringe barrel 50 is greater in the drug compartment 54 than in the diluent compartment 53. Thus, while internal piston 52 makes a sealed sliding fit with the narrower bore, it becomes loose in the wider bore of the drug compartment. Alternatively, the barrel could be of a constant diameter with a channel along part of the interior surface providing a pathway for the diluent. A lyophilised drug 55 is provided in the drug compartment together with a quantity of entrapped air. Diluent compartment 53 is entirely filled with liquid diluent 56 suitable to reconstitute the drug 55.
When gas generation begins, the pressure acting on end piston 51 is transmitted through the diluent 56 to push internal piston 52 towards drug compartment 54. Continued gas generation pushes internal piston 52 entirely into drug compartment 54 (
Although a certain amount of air is pushed through needle 17 ahead of the drug solution, the amount involved will not have any adverse effect if delivery is subcutaneous. The design of the device can also be optimised to minimise or eliminate air from being delivered. Delivery of drug continues until the position shown in
It should be noted that the barrel 50 and pistons 51,52 are shaped such that gas cannot be pumped to the patient after delivery of the drug is completed.
The advantage of this arrangement is that it converts the device of
For example in a series of two devices (sizes "A" and "B"), each being adjustable to deliver from 70% to 100% of the total pre-filled dose, size "A" may contain 100 units (arbitrary units). Thus, device "A" can deliver from 70 to 100 units by adjustment of suitable travel limiting means. If device "B" is pre-filled with 70 units, then it can deliver from 70% to 100% of this dose, i.e. from 49 to 70 units. Thus, with only two devices, doses from 100 units down to less than 50 units can be catered for, covering a wide range of patients on a mg/kg dosage basis. Adding third or fourth device sizes to the series extends the possible delivery amounts even further.
It is to be understood that the illustrated travel limiting means are intended only for illustrative purposes and that a wide variety of equivalent means to control the dosage delivered may be employed.
Furthermore, while the invention has been shown with a simple gas generator which delivers the drug at a rate determined by the mixing of an effervescent couple, the gas generator could also be a more sophisticated, controllable generator, such as an electrolytic cell which generates gas at a rate determined by a current which is electronically controlled.
As used herein, the term, "drug", is meant to encompass any drug-containing fluid capable of being passed through a hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension. The term "drug" used herein includes but is not limited to peptides or proteins (and memetics thereof), antigens, vaccines, hormones, analgesics, anti-migraine agents, anti-coagulant agents, medications directed to the treatment of diseases and conditions of the central nervous system, narcotic antagonists, imunosuppressants, agents used in the treatment of AIDS, chelating agents, anti-anginal agents, chemotherapy agents, sedatives, anti-neoplastics, prostaglandins, antidiuretic agents and DNA or DNA/RNA molecules to support gene therapy.
Typical drugs include peptides, proteins or hormones (or any memetic or analogues of any thereof) such as insulin, calcitonin, calcitonin gene regulating protein, atrial natriuretic protein, colony stimulating factor, betaseron, erythropoietin (EPO), interferons such as α, β or γ interferon, somatropin, somatotropin, somastostatin, insulin-like growth factor (somatomedins), luteinizing hormone releasing hormone (LHRH), tissue plasminogen activator (TPA), growth hormone releasing hormone (GHRH), oxytocin, estradiol, growth hormones, leuprolide acetate, factor VIII, interleukins such as interleukin-2, and analogues or antagonists thereof, such as IL-lra; analgesics such as fentanyl, sufentanil, butorphanol, buprenorphine, levorphanol, morphine, hydromorphone, hydrocodone, oxymorphone, methadone, lidocaine, bupivacaine, diclofenac, naproxen, paverin, and analogues thereof; anti-migraine agents such as sumatriptan, ergot alkaloids, and analogues thereof; anti-coagulant agents such as heparin, hirudin, and analogues thereof; anti-emetic agents such as scopolamine, ondansetron, domperidone, metoclopramide, and analogues thereof; cardiovascular agents, anti-hypertensive agents and vasodilators such as diltiazem, clonidine, nifedipine, verapamil, isosorbide-5-mononitrate, organic nitrates, agents used in treatment of heart disorders, and analogues thereof; sedatives such as benzodiazepines, phenothiazines, and analogues thereof; chelating agents such as deferoxamine, and analogues thereof; anti-diuretic agents such as desmopressin, vasopressin, and analogues thereof; anti-anginal agents such as nitroglycerine, and analogues thereof; anti-neoplastics such as fluorouracil, bleomycin, and analogues thereof; prostaglandins and analogues thereof; and chemotherapy agents such as vincristine, and analogues thereof, treatments for attention deficit disorder, methylphenidate, fluoxamine, Bisolperol, tactolimuls, sacrolimus and cyclosporin.
It will further be appreciated that many of the embodiments discussed above are preferred embodiments, falling within the scope of the invention, and that various alternative embodiments are contemplated.
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|Jun 24, 2014
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|Jul 6, 2011
|Jul 8, 2014
|Medical Components, Inc.
|Syringe for sequential expression of different liquids
|Jul 12, 2011
|Jul 8, 2014
|Medical Components, Inc.
|Method of using a syringe
|Dec 19, 2012
|Sep 2, 2014
|Valeritas, Inc.
|Multi-cartridge fluid delivery device
|Jan 19, 2011
|Dec 23, 2014
|Medimop Medical Projects Ltd.
|Needle assembly for drug pump
|Jul 29, 2010
|Jan 6, 2015
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|Sep 2, 2010
|Feb 3, 2015
|Becton, Dickinson And Company
|Self-injection device having needle cover with activation preventer
|Dec 16, 2009
|Feb 24, 2015
|Becton, Dickinson And Company
|Self-injection device
|Aug 7, 2009
|Mar 24, 2015
|Tandem Diabetes Care, Inc.
|Two chamber pumps and related methods
|Apr 30, 2013
|Apr 21, 2015
|Medimop Medical Projects Ltd.
|Clip contact for easy installation of printed circuit board PCB
|Mar 26, 2012
|Jul 7, 2015
|Medimop Medical Projects Ltd.
|Fail safe point protector for needle safety flap
|Dec 16, 2008
|Jul 7, 2015
|Valeritas, Inc.
|Hydraulically actuated pump for long duration medicament administration
|Jul 5, 2005
|Jul 28, 2015
|Valeritas, Inc.
|Methods and devices for delivering GLP-1 and uses thereof
|Apr 17, 2010
|Sep 8, 2015
|Valeritas, Inc.
|Hydraulically actuated pump for fluid administration
|Mar 19, 2009
|Oct 1, 2009
|Lifescan Inc.
|Medical Device Mechanical Pump
|Dec 29, 2011
|Robert Wilk
|Medical device mechanical pump
|Mar 22, 2011
|Apr 15, 2014
|Medimop Medical Projects Ltd.
|Cartridge for use in injection device
|U.S. Classification
|604/141, 604/110, 604/272
|International Classification
|Cooperative Classification
|European Classification
|Nov 21, 2001
|Oct 6, 2003
|Jul 18, 2008
|Fee payment
Year of fee payment: 4
|Sep 29, 2011
Owner name: MORGAN STANLEY SENIOR FUNDING, INC., NEW YORK
Free format text: PATENT SECURITY AGREEMENT (SECOND LIEN);ASSIGNORS:ALKERMES, INC.;ALKERMES PHARMA IRELAND LIMITED;ALKERMES CONTROLLED THERAPEUTICS INC.;REEL/FRAME:026994/0245
Effective date: 20110916
Owner name: MORGAN STANLEY SENIOR FUNDING, INC., NEW YORK
Free format text: PATENT SECURITY AGREEMENT (FIRST LIEN);ASSIGNORS:ALKERMES, INC.;ALKERMES PHARMA IRELAND LIMITED;ALKERMES CONTROLLED THERAPEUTICS INC.;REEL/FRAME:026994/0186
Effective date: 20110916
|Jul 18, 2012
|Fee payment
Year of fee payment: 8
|Oct 12, 2012
Owner name: ALKERMES CONTROLLED THERAPEUTICS INC., MASSACHUSET
Free format text: RELEASE BY SECURED PARTY (SECOND LIEN);ASSIGNOR:MORGAN STANLEY SENIOR FUNDING, INC.;REEL/FRAME:029116/0379
Effective date: 20120924
Owner name: ALKERMES, INC., MASSACHUSETTS
Free format text: RELEASE BY SECURED PARTY (SECOND LIEN);ASSIGNOR:MORGAN STANLEY SENIOR FUNDING, INC.;REEL/FRAME:029116/0379
Effective date: 20120924
Owner name: ALKERMES PHARMA IRELAND LIMITED, IRELAND
Free format text: RELEASE BY SECURED PARTY (SECOND LIEN);ASSIGNOR:MORGAN STANLEY SENIOR FUNDING, INC.;REEL/FRAME:029116/0379
Effective date: 20120924


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Although they hesitated, the Mecklenburg County Board of Commissioners approved granting up to $6.48 million in federal Recovery Zone Facility Bonds to Red City Properties Tuesday. But first, commissioners questioned whether their approval of the funding could entangle the board in an ongoing lawsuit ...Read More »
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Commissioners up fines for air-quality violations
It just got more expensive to violate Mecklenburg County's air-quality laws. On Tuesday, the Mecklenburg County Board of Commissioners approved revisions to its air-quality ordinance, raising the maximum penalty for a violation from $10,000 per day to $25,000 per day, a measure ...Read More »
Cuts being considered for Blue Line
Based on recommendations from a financial consultant for the Charlotte Area Transit System, the planned Blue Line light-rail extension may be trimmed to make it more affordable. On Wednesday, Jeff Parker suggested to the Metropolitan Transit Commission that if CATS could find ways to cut ...Read More »
Lanes to open in $18M Providence Road project
Providence Road between the Mecklenburg County line and Rea Road will open to traffic Friday if weather permits, according to the North Carolina Department of Transportation. Scurry Construction of Cornelius was awarded an $18 million contract to widen 3 1/2 ...
Tagged with: North Carolina Department of TransportationRead More »
Carolina Trust Bank offers up to 1.8M shares
Lincolnton-based Carolina Trust Bank has announced a public offering of up to 1.8 million shares of its common stock. The bank, which has six branches in Denver, Gastonia, Lincolnton and Vale, could sell up to 270,000 additional shares as part of the offering. ...
Tagged with: Carolina Trust BankRead More »
25 tons of county waste recycled
Two recycling initiatives are being credited with the removal of 25 tons of waste in Mecklenburg County. According to the Mecklenburg County Waste Management Advisory Board, a program developed by the county to shred and recycle sensitive documents netted 23 tons ...
Tagged with: Carolina Panthers Keep Mecklenburg Beautiful Mecklenburg County Waste Management Advisory BoardRead More »
Economy blamed for zoning fouls
Charlotte's restaurants have given the city's zoning officials something to chew on this year. Eateries next to residential areas have been busted for bringing in entertainment, such as disk jockeys, which puts them in violation of their zoning. As a ...
Tagged with: Cosmos Cafe Fred LeFranc Gold Palacios Mexican Restaurant and Bar Katrina Young North Carolina Restaurant and Lodging Association Paul Stone Results Through Strategy Tom StroozasRead More »
Investor news brings hope to EpiCentre contractors, tenants
With an announcement that an unnamed investor may purchase a $93.9 million loan on the EpiCentre, a group of about 40 contractors and others who say they are owed more nearly $10 million is wondering what the news means for ...
Tagged with: Afshin Ghazi Dennis O'Dea EpiCentre Farrell Mauldin George Cornelson Regions Bank Steel SpecialtyRead More »
Lowe's, National Gypsum deny drywall accusations
Two major Charlotte-area companies — home improvement retailer Lowe's and drywall supplier National Gypsum — have been caught up in the Chinese drywall controversy. The drywall has been blamed for a host of problems cited by homeowners, from breathing difficulties ...
Tagged with: Homebuilders Association of Charlotte Lowe's Mark Baldwin National GypsumRead More »
SPX starts building China facility
After announcing Monday that it will spend $70 million to build global headquarters in Mecklenburg County, SPX Corp. broke ground Tuesday on a 53-acre manufacturing campus in China. SPX said the $40 million investment in China will be spread over the next three ...
Tagged with: SPX Corp.Read More »

subset: commoncrawl


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Bill Rancic Defends His Wife Giuliana After Fashion Police Controversy: 'I Tried to Get Them to Release the Footage' 41 years, 2,191 covers and 55,436 stories from PEOPLE magazine's history for you to enjoy
Latest News!
- FROM EW: T.I. Apologizes for Saying a Woman Can't Be President: 'My Comments Were Unequivocally Insensitive and Wrong'
- Read the Cover Story: How Blake Shelton Is Moving On After Split
- Yum! Watch Karlie Kloss Make Her Signature 'Apple Krisp' Recipe (VIDEO)
- The Voice Alum RaeLynn Is Engaged! See the Ring
- Jennifer Lawrence's Most Badass Quotes
On Newsstands Now
- Matthew McConaughey: In His Own Words
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People Top 5
LAST UPDATE: Tuesday February 10, 2015 01:10PM EST
PEOPLE Top 5 are the most-viewed stories on the site over the past three days, updated every 60 minutes
- August 20, 2001
- Vol. 56
- No. 8
Picks and Pans Review: The Manhattan Hunt Club
Heart-of-darkness storyteller Saul weaves a creepy tale of murder, corruption and evil in a perfect setting: the New York City subway. The result is scarier than trying to do the Macarena between cars on a speeding F train. College smarty Jeff Converse winds up wrongly convicted of a brutal crime on a subway platform; instead of going to prison, he gets abducted and abandoned in a maze of chambers below the city streets. There he becomes human game for a secret society—the Manhattan Hunt Club "of fair-minded people who have the greater good of the city and its citizens at heart." "The Most Dangerous Game," meet The Warriors.
With a little help from a criminally insane sidekick, Jeff turns the tables on the predators, who track him with the aid of a double-dealing friend of the homeless. In the end it's the power of love that helps the hapless and hangs the heels. Stirring social commentary, this ain't, but it's a hot tome for summer in the city. (Ballantine, $25.95)
Bottom Line: Happy hunting
- Contributors:
- Bella Stander,
- Edward Karam,
- Cathy Burke,
- Michelle Vellucci,
- Amy Waldman.
More in the Archive
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October 10, 2015
Kirsten Dunst, Liam Hemsworth, Halle Berry and More!
Treat Yourself! 4 Preview Issues
The most buzzed about stars this minute!


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FreakScore is a weighted average of all aggregated professional and user review scores. Read more
This product has a FreakScore of 4.8* out of 10 based on 2 scores.
*Score is uncertain and deviates toward category average due to low number of scores.
The HP LaserJet M5025 Multifunction Printer serves a variety of Read more


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Flex Developer, Air Developer
India - Portfolio: 1
Looking forward to an opportunity to work in a progressive and challenging environment where I can enhance my skills and potentials to achieve perfection in my job through hard work.
Browse BlazeDS job posts for project examples or post your job on Upwork for free!
Typical total cost of Upwork BlazeDS projects based on completed and fixed-price jobs.
On average, 0 BlazeDS projects are completed every quarter on Upwork.
Time needed to complete a BlazeDS project on Upwork.
BlazeDS Upwork freelancers typically receive a client rating of 5.00.
India - Portfolio: 1
Looking forward to an opportunity to work in a progressive and challenging environment where I can enhance my skills and potentials to achieve perfection in my job through hard work.
Sri Lanka - Tests: 2 - Portfolio: 10
Serve the client with utmost satisfaction!
Moldova - Tests: 4 - Portfolio: 7
Experienced developer with outstanding Java/J2EE and Flex skills. Have been working with all modern java techologies and related. Organized, realible, self-motivated and agile developer and project manager. I can take a project from the initial concept stages, create a system design and implement it successfully. Guaranteed qulity and in time delivery!!!!
Associated with: SanDevelop Agency
Ukraine - Tests: 3
I am a Flex/Flash developer with over 6 years solid experience with creating Flash and Flex based applications with different complexity. Also I have a high level of knowledge in HTML, PHP, JavaScript, Java and SQL which allows me to build client-server solutions. I am seeking for the opportunity to work on a projects where I can apply my skills at the full extent.
Groups: Coding Champs
India - Portfolio: 15
Over 6 years of experience in developing innovative applications, games and websites in Flash, Facebook games, AS3, Flex, AIR etc. Always looking forward for challenging projects that provides opportunities to keep abreast with latest development and trends in the software industry.
Associated with: Rain Concert Technologies (P) Ltd
India - Tests: 8 - Portfolio: 14
Exemplary skills in developing Enterprise Applications using J2EE technologies. I have successfully executed ERP implemenations and developed business solutions using JAVA, Hibernate, Flex, Ajax. Seeking opportunities to utilize the knowledge I have gained and to leverage my skills in executing technically challenging projects .
Associated with: Rain Concert Technologies (P) Ltd
India - Tests: 2 - Portfolio: 7
• Possess an ability to define processes to drive a project to a successful Software Delivery. • Expertise in various methodologies including Agile, Scrum, Test Driven Development, Extreme Programming, Iterative and Object Oriented Modeling. • ScrumMaster Certified from Scrum Alliance. • Expertise in Wealth Management domain including Corporates and PWM. Knowledge in IED domain including FIX protocol and pre/post trading activities. • Involvement in requirements gathering & analysis, estimations, system design, delivery and post-delivery support. • Effective communication and coordination skills with team members, other teams and technology groups. • Other experiences include Spring, Struts, Web Services, MQ, Hibernate, EJB, Apache Ant, Ivy, Cruisecontrol, Electric Commander, Jboss, Apache and Tomcat. • Knowledge of application security using SSL, Siteminder, Kerberos and E3 (Eclipse Entitlement Engine). • Operating System – linux and windows. Databases – Oracle, MS SQL Server, Sybase
Australia - Tests: 1
I am a java software engineer for 8 years. I have worked in the big companies in Egypt (IBM Egypt, ESRI Nea, ITWorx, Vodefone, Asset). I am shifting for the free lancing profile since I am looking for more flexibility, leveraging the technical skills, and working in concurrent project.
India - Tests: 3 - Portfolio: 11
I have• Over 9+ years of diverse experience of developing Web Application, online games E-Learning and Multimedia Products. Using the latest tools including Adobe Flash, Flex, Adobe AIR, BlazeDS, Web services and other web messaging technology. Expert level command of Action Script 3.0 and Action Script 2.0.• Extensive knowledge and experience of web application architecture, GUI design and development.• Success in all aspects of project & design from concept to delivery including specification development, coding and implementation.• Sound knowledge of RIA in web world.• Good Experience in Cairngorm and MVC• Specialized in Object-Oriented Action Scripting (OOPS).• Sound knowledge of design patterns and XML.
Groups: salesforce.com
Belarus - Tests: 3 - Portfolio: 2
4 years of experience in software development \ design \ consulting \ managment (mostly web applications). Substantial experience in highload enterprise projects. Here is a draft list of technologies familiar to me: Java, j2ee (JSP, Struts, GWT,etc.), MySQL, Oracle, HTML/CSS/JavaScript, Linux, Amazon Web Services. I do my job in such a way that the customer can relax and delegate all his concers to me. Full project support at all stages: from team hiring (in case it's needed) and primary design to handing over the complete production version, overall testing, profiling and performance tuning. I already have quite a big number of well-designed completed and time proven carcass frameworks for various types of applications and architectures. These ready solutions will in most cases allow you to save 100+ hours. You are welcome to apply for a free estimate and consultation on your project.


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Smile Michigan Pro
Courses appearing below are sponsored by various district dental societies. To list a course, send complete course information to Jackie Hammond at the MDA office.
NOTE: The MDA encourages local dental societies to publicize courses and speakers online and in the MDA Journal's Continuing Education listings. These listings are published when submitted and should not be considered a definitive list or master calendar of all component CE courses offered in the state of Michigan. Local societies planning CE events are urged to contact other components when scheduling courses to avoid conflicting dates.
Friday, Oct. 9, 2015 — Macomb District Dental Society
Speakers: Prasanna-Kumar Shivapuja, BDS, MDS, DDS, MS; Robert Stewart, DDS, MS; James Lepczyk, DDS
Time: 8 a.m. to 4 p.m.
Where: Royal Park Hotel, 600 E University Dr, Rochester, MI 48307 (map)
Cost: $205
CE Credits: 6
Contact: Drs. Chris and Michelle Gorecki at (586) 751-7777
Tuesday, Oct. 20, 2015 — Livingston District Dental Society
Speaker: Gregory W. Petersburg, DO
Time: 6 to 9 p.m.
Where: 3125 Golf Club Road, Howell, MI 48843 (map)
CE Credits: 2
Contact: Dr. William Metz at (810) 229-6318
More than 75 percent of all medical problems that now cause people to consult health care professionals are largely preventalbe or remedial through health behavior change. Yet, patient adherence to preventive recommendations and therapies suffers at less than 28 percent. The "directive" communication style taught to clinicians is a significant contributor to this problem. "Change talk," or motivational interviewing, provides a modern, evidence-based alternative to the outdated direct persuasion approach to changing patient behavior, by helping patients resolve ambivalence and activating the patient's own motivation for change to improve their health. Motivational interviewing results in statistically significant improvements in patient adherence to lifestyle behavior changes, as well as increased patient and provider satisfaction.
This timely session provides dentists with essential new and practical interviewing and communication skills that can readily be incorporated into any health care setting. This session involves audience skill-building activities. It is highly recommended that practice staff members attend.
At the conclusion of the session, the practitioner and staff members will be able to:
Tuesday, January 19, 2016 — Livingston District Dental Society
Speaker: Roy S. Shelburne, DDS
Time: 6 to 9 p.m.
Where: Crystal Gardens Banquet Center, 5768 E Grand River Ave, Howell, MI 48843 (map)
CE Credits: 2
Contact: Dr. William Metz at (810) 229-6318
Dr. Shelburne went to prison in 2008 and was released in 2010 after learning a series of lessons the hard way. There are ways to protect and defend a dental practice and to prevent what happened to him from happening to you. You can protect your practice in the event of a Board complaint, insurance audit, malpractice claim, or criminal complaint.
Dr. Shelburne found that his records and systems were faulty. He learned that it is critical and possible to implement protocols and form a defensive systemic approach to record-keeping. To be prepared for any challenge the whole dental team must be careful, concise, complete, and diligent — not just the doctor.
Learning and implementing this no nonsense team approach to record-keeping could mean the difference between success and failure in the event of an action or challenge to your practice. "I'm passionate about helping my colleagues understand that if it's not in your dental record, you didn't see it, you didn't say it, you didn't do it, it didn't need to be done, and it doesn't exist from the legal perspective," he said.
Seminar attendees will learn to:
CE Courses
3657 Okemos Road., Ste. 200
Okemos, MI 48864
Ph: 800-589-2632 | Ph: 517-372-9070
Fax: 517-372-0008
Be sure to keep up with our latest news &
announcements by finding us on Facebook
Check out practice management tips, treatment resources
and promotional videos on MDA's YouTube channel.
3657 Okemos Road., Ste. 200
Okemos, MI 48864
Ph: 800-589-2632 | 517-372-9070
Fax: 517-372-0008
Copyright © 2015 Michigan Dental Association | Privacy Policy
Website design and development by Web Ascender
Copyright © 2015 Michigan Dental Association | Privacy Policy
Website design and development by Web Ascender


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greeting cards, tangerines greeting cards, fruit greeting cards, vase greeting cards, shadows greeting cards, food greeting cards, kitchen greeting cards, dining room greeting cards
"Tangerines" greeting card by Joe Bergholm. Ships within 2 - 3 business days and includes a plain white envelop for mailing and/or gift giving. Available in vertical and horizontal orientations.
Joe is an award winning artist from Red Bank, New Jersey whose work is held in private, municipal, and corporate collections. He specializes in using the new line of Golden OPEN Acrylic paints. Joe is Artist in Residence for the Red Bank Public Library Adult Painting Workshops, and a past president of the Plein Air Painters of the Jersey Coast. Please visit his web site: www.joebergholm.com. His work, "Not So Still Life", is included in the Golden Paint Company new product brochure in Japan, http://www.turner.co.jp/art/goldenopen/index.html. He is a registered teacher with the School of Color (SoC), USA, http://www.schoolofcolor.com
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
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Maine New England Dark turquoise striped scoop neck top
Item No.0200101256
Item No.0200101256
70% Off - Save a total of £14.00
This women's scoop neck top from Maine New England comes in dark turquoise with a black multi striped design. It has solid black panels on the shoulders with mock button details and three quarter sleeves.
UK Home Delivery Free (UK orders over £30) or £3.49
Delivered within 5 working days
Next or Named Day Delivery
7 days a week between 8am - 6pm
Sunday to Friday - order by 9pm - £3.99
Saturday - order by 6pm - £3.99
Next or Named Evening Delivery
7 days a week between 6pm - 10pm
Monday to Sunday - order by Midnight - £6.99
Collect from store the next day - FREE
Order before 9pm for next day collection after 12pm midday
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Subject to exceptions, Debenhams is happy to exchange or refund your purchase within 28 days of delivery. Please check here for more details on our returns policy and exceptions.


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Courtyard by Marriott Jacksonville Beach Oceanfront
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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TravelPod Member ReviewsCourtyard by Marriott Jacksonville Beach Oceanfront
Nice, newer Oceanfront property on the extreme north end of Jacksonville Beach. At 16th Ave., North, it is a long way from downtown Jax Beach and from the excellent restaurants in Atlantic Beach. Difficult to walk. Nice pool area, tiki bar, casual restaurant and small bar, quiet. Parking was definitely an issue - but overflow is allowed in the Fairfield Inn across the street. Renovation of the lobby/restaurant scheduled to be done by April 1, 2014. Looks like that will be a major improvement.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Courtyard by Marriott Jacksonville Beach Oceanfront
Travel Blogs from Jacksonville Beach
Ridgeway, Sth Carolina to StAugustine, Florida
... In 1738 the first legally sanctioned free community of former slaves, Gracia Real de Santa Teresa de Mose, was established as part of the presidio's northern defenses. In 1740, an even stronger attack on St. Augustine was mounted by the Governor of the British colony of Georgia, General James Oglethorpe. He also failed to take the fort. The Treaty of Paris in 1763, ending the French and Indian War, gave Florida and St. Augustine to the British, accomplishing by the stroke of a ...
Wes- Quick Trip to Florida
... special treat! Not many classic warbirds at our cross-country gas stops;-) Now back in the relatively cool mountain climate after the swelter in Florida, the plan is to get the Highlander repacked and restocked for the trek across the country. I have some work to do on airplanes (Tiger, Highlanders, etc) before I leave, so it may be a couple days before I head ...
One week in
... back bigger, I just hope it's muscle and not fat. At least that's what Laura's told me anyway. I finally got fed up of not being able to make any proper food though and bought a skillet which is like an electric heated pan and lid, which can apparently roast, grill, fry and stew. So I'll finally be able to take advantage of the tempting steaks in the supermarket. Shopping here is really cheap as all of the shopping on base is tax free. Unfortunately this also extends to the ...
Hanna Park
Friday November 22nd: Glorious day in Hanna Park. You must stay at Hanna Park!! Leah had recommended it and here you get it all. Feels like you're in a tropical jungle. You have the Atlantic Ocean on one side of the park and a beautiful lake on the other. Nature...Nature...Nature. Thank you God for the wonderful world you created. You are so majestic!!!
Leon and I walked on ...
Very cloud, no rain.
Very cloud, no rain.
Life is like that sometimes. We expect one thing based on observation, but it doesn't happen.
The weatherman said the rain wouldn't make it to the beach, so, despite my senses telling me to drive, I walked from my hotel down to Neptune Beach for supper. I wanted calzone. People told me Al's is the best pizza shop, so that was my destination.
Jacksonville Beach is very pretty, with a tranquil, ...


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The SEO Expert Guide: How to get to the top of the search engine rankings - and stay there!Crawler-based search engines have become the gateway to the World Wide Web - used by millions worldwide to locate the resources they need. By typing a few key words into a little box, literally thousands of results are served up in strict order of relevance. Many users never make it beyond page one (before finding what they need). Getting to the top of those results for your key words and
The Intranet Portal Guide: How to Make the Business Case for a Corporate Portal, Then Successfully DeliverAn intranet portal project may well be the first and last project in your organisation that truly touches everyone, from the office of your CEO to the newest recruit. It may well be the most significant investment that you ever make in your people, their processes and their systems and has the power and potential to transform your organisation. However, it can be a tough project to deliver,
The eBook Self-publishing Guide: Desktop to Amazon in 10 Easy StepsTraditional publishers tend to have a very set idea of what they are looking for and what will sell well. As any author of the printed word will testify, you can literally wallpaper your study with rejection letters over the course of your career. Worse still, as an author you might only earn 5% of the list price of your book (after everyone else involved has taken their cut) and it could take up
$19.99Ireland conjures up images of nature's majesty: sweeping coastlines, rolling green hills, and secluded peat bogs and marshlands. A place of legendary beauty, it is also a land with a rich natural history. Michael Viney invites us to discover the geologic forces that created the island, peer into the famous bone caves that hold unique clues about animals from long ago, and experience the dramatic
$26.59Why are people so interested in what they and others throw away? This book shows how this interest in what we discard is far from new - it is integral to how we make, build and describe our lived environment. As this wide-ranging new study reveals, waste has been a polarizing topic for millennia and has been treated as a rich resource by artists, writers, philosophers and architects. Drawing on
Personal Construct MethodologyWritten by an international team of experts, this collection provides a comprehensive account of established and emerging methods of collecting and analysing data within the framework of personal construct theory. Covers methods such as content analysis scales, repertory grid methodology, narrative assessments and drawings, the laddering and ABC techniques, and discusses how and why they are
$152.99A History of Psychology: Ideas & Context, 5/e, traces psychological thought from antiquity through early 21st century advances, giving students a thorough look into psychology's origins and development. This title provides in-depth coverage of intellectual trends, major systems of thought, and key developments in basic and applied psychology.
A Skills-based approach to teaching and learning English"English is an important subject today. It is also a difficult subject to teach. Large heterogeneous classes, anachronistic syllabi, boring textbooks boringly taught and purposeless examinations demotivate students from taking English seriously at college.In the twenty-first century there is a need for professionals to be adept at writing, speaking and understanding English because they have to
$8.89In his first solo collection, a poet called Dave gives his unique insight into a background that rarely pushes poets to the foreground. Exploring the legend of angry dads, the fragility of 'lad's lads' and the condition that threatened his future as a performer, these are poems that turn life on its head to see what falls out of its pockets. A funny, unflinching and heartfelt journey from the
$8.15Working Verse Collective are three lads on a mission and their mission statement is this: Eloquence is fine. But "eloquence is irrelevant when nobody in the room knows what you meant..." Join poets Dave Viney, Kieren King and Benny-jo Zahl as they expertly weave humour, insight and the unexpected throughout their quest to discover if they have "The Right Stuff" - and what that actually is and if


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BackgroundSwipe your finger across the screen to deliciously slash and splatter fruit like a true ninja warrior. Be careful of bombs – they are explosive to touch and will put a swift end to your juicy adventure!
Fruit Ninja features Classic, Zen and the amazing new Arcade mode, along with online multiplayer for Game Center-enabled devices! It also has awesome global leaderboards and achievements to unlock.
Your success will also please the wise ninja Sensei, who will accompany your journey with wise words and fun fruit facts.
Fruit Ninja is the messiest and most satisfying fruit game ever!
Game Play
Hardware Info
Official URLOfficial Website
Recent threads
Quixotic owns Fruit Ninja
Lone LabSlicing fruits all day long. Cute. FruitNinjaKinect X360
Dec 22, 11 9:34am
Lone LabSlicing fruits all day long! FruitNinjaKinect X360
Dec 20, 11 4:45pm
harvestmoonmaniacBest game ever. FruitNinjaKinect X360
Jul 03, 11 3:35pm
- Genre: Platformer Action (Android)
- Perspective(s): First Person,Third Person
- Developer: Halfbrick Studios
- Publisher: Halfbrick Studios
Released North America September 2010


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Gate Latch Weld-in Spring loaded cattle corral gate latch.
Super economical Weld-in Spring loaded cattle corral gate latch. This small automatic gate latch has a heavy duty 1/2" diameter spring loaded plunger pin and handle with a total length of 6 inches. Outside tube is 1 inch diameter and 3 inches long.
This is an excellent heavy duty corral gate latch or stop assembly.
Weld on catch for the permanent post or gate outside frame is also available, just see our other products.
See us for many of your fencing, corral, gate, latch needs for farm or ranch. Call us for quantity freight prices as well as mix and match of different products in one shipment.
This exact latch is used on many commercially built corrals in cattle feed lots and yards as well as commercial and private stock yard facilities. I use these on my cattle ranch and they are excellent latches.
Call us at 800 283 7107 M-F 8-5 Central time or email me at firstname.lastname@example.com 24/7 for more i


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2014 marks the 7th Annual Royal City Farmers Market Summer Kickoff Fundraiser Party and we want you to celebrate with us!
This event is a critical part of ensuring our market continues to flourish in New Westminster. Proceeds from this event help us do food-positive actions such as offering a bursary to New Westminster Senior Secondary grads entering food-based fields, as well as bringing lively entertainment and children's activities to the market every week to encourage a sense of community at the market.
This year, we are very excited to announce the fundraiser takes place at the recently opened and much-lauded Hub Restaurant at Shops at New West Station. Executive Chef Michael Knowlson is creating a special "off the menu" tableau of canapes to delight your taste buds for the entire evening. Chef Knowlson has served as Executive Chef at Bacchus Restaurant in the Wedgewood Hotel and at Sequoia Grill at the Teahouse in Stanley Park. Prior to moving to Vancouver, he served as Executive Chef of cutting-edge London restaurants First Floor and 192, along with the private Groucho Club, where he cooked for such notables as Bill Clinton, Tom Cruise, Julia Roberts and Al Pacino.
The canape menu will consist of ingredients donated by our delicious vendors: Wild West Coast Seafoods, Outwest Ranch, Golden Ears Cheesecrafters, and Rockweld Farms. For one night only you'll experience the true taste of our farmers market in the hands of this master chef!
Join us for an evening of mingling with fellow foodie enthusiasts, interactive entertainment, local food at it's finest, and of course local libations! A silent auction will be available to tempt you with fine #madeinnewwest wares, and to kick it up a knotch we'll also be having a live auction hosted by Citizen of the Year Patrick Johnstone.
This is one event in our Royal City that you definitely don't want to miss. Tickets will sell out so buy now and bring your friends. RCFM needs your support to continue to do food-positive actions, PLUS we know it will be a fun party – it's win-win for everyone!
Tickets must be purchased via Eventbrite: https://www.eventbrite.ca/e/royal-city-farmers-market-7th-annual-fundraiser-and-summer-kickoff-tickets-11487572639?ref=ebtnebtckt
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— Rafaël, started French Conversation Group
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Movie News
George Clooney and Scarlett Johansson Channel Old Hollywood in Hail Caesar! Trailer (October 9, 2015): George Clooney. Scarlett Johansson, Josh Brolin and Channing Tatum star in the trailer for Hail, Caesar!, the Coen brothers' comedy about Old Hollywood and its many scandals.
Lily James Fights Zombies in Pride and Prejudice and Zombies Trailer (October 9, 2015): Lily James fights zombies in her spare time in the horror comedy Pride and Prejudice and Zombies. Seth Grahame-Smith's novel added zombies to the Jane Austen classic.
Jaws 19 Trailer from Universal Pictures (October 8, 2015): Universal Pictures shared this trailer for Jaws 19 to promote the 30th anniversary of Back to the Future.
A Dinosaur and His Boy Face Adventure in The Good Dinosaur Trailer (October 8, 2015): Pixar's newest film The Good Dinosaur asks the question: what if the asteroid that wiped out the dinosaurs missed Earth?
The Martian Tops Weekend Box Office (October 4, 2015): The Martian, starring Matt Damon, won the box office this weekend. It made $55 million.
Malala and Stephen Colbert Do Card Tricks (September 27, 2015): Nobel Peace Prize winner Malala Yousafzai showed Stephen Colbert a new card trick. Earlier in the day the 18 year old addressed the United Nations about education for girls.
Hotel Transylvania 2 Tops Weekend Box Office (September 27, 2015): Hotel Transylvania 2 topped the box office this weekend. It made $47 million and finished well ahead of The Intern.
Angry Birds Trailer Features Voices of Jason Sudeikis, Josh Gad and Danny McBride (September 25, 2015): The Angry Birds Movie trailer has been released. It features the voice work of Jason Sudeikis, Josh Gad and Danny McBride.
Maze Runner: The Scorch Trials Tops Weekend Box Office (September 20, 2015): Maze Runner: The Scorch Trials topped the box office this weekend. The film made $30.3 million and defeated Black Mass.
Scarlett Johansson is Kaa the Python in First Jungle Book Trailer (September 18, 2015): Jon Favreau's Jungle Book trailer is visually stunning. The live action and cgi film stars Neel Sethi and the voices of Scarlett Johansson, Bill Murray and Lupita N'ong'o
For Prim Trailer Shows the Bond Between Katniss and Primrose Everdeen (September 16, 2015): New trailer for The Hunger Games Mockingjay Part 2 shows the enduring love between sisters Katniss and Prim Everdeen.
Shailene Woodley Stars in First Allegiant Trailer (September 15, 2015): Shailene Woodley and Theo James leave the walled city in the first trailer for Allegiant, the third film in the Divergent franchise.
Sharlto Copley Stars in First Trailer for Hardcore (September 14, 2015): Sharlto Copley stars in the first trailer for the sf thriller Hardcore. The film is the first to be shot entirely from the protagonist's point of view, like a video game.
Sarah Silverman is a Drug Addicted Housewife in I Smile Back Trailer (September 13, 2015): Sarah Silverman stars as a wealthy New Jersey housewife who sinks into drugs and alcohol in the trailer for I Smile Back which is based on the novel by Alice Koppelman.
The Perfect Guy Tops The Visit to Win Weekend Box Office (September 13, 2015): The Perfect Guy won the weekend box office. It just barely held off The Visit horror film from M. Night Shyamalan.


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Get the Wolves newsletter
Get the latest news from Wolves delivered for FREE to your inbox.
08:55 2nd August 2013
The Wolves Saver account has got off to a great start, with junior accounts proving to be particularly popular.
There is still time to qualify for the very special Wolves Saver Competition. Anyone opening an account from today until Saturday 3rd August 2013 will be entered into a draw to win two tickets to WV1 Bar at the first league game at Molineux against Gillingham on Saturday 10th August 2013. That includes two tickets for WV1 Bar in the Stan Cullis Stand, a car park pass, two matchday programmes, complimentary drink, luxury matchday seating and the opportunity to purchase food on the day. Terms and conditions apply.
Supporters can earn fantastic interest rates on their savings as well as rewards for hitting savings targets and be in with a chance of winning prizes, all whilst supporting the Club!
The junior account is available for under all 16's.
To sign up for a new account, visit us at any of the four Tipton & Coseley branches in Tipton, Coseley, Bilston and Sedgley or call 0121 557 2551 to request an application form.
More details on the account can be found at www.thetipton.co.uk
Terms and Conditions
Competition open to anyone opening a Wolves Saver Account with Tipton & Coseley Building Society between Monday 29th July 2013 and Saturday 3rd August 2013. Junior account holders will be entered but if selected will have to be accompanied by an over 18. The prize is for 2 tickets for WV1 Bar in the Stan Cullis Stand for Wolves v Gillingham on 10th August 2013 and cannot be transferred to an alternative game or prize. Should the game be postponed for any reason the prize will be valid for the re arranged date. The winner will be announced on wolves.co.uk the week commencing 5th August 2013.
Fine start to season continues
1 day ago
News of fixture changes
4 days ago
Chance to represent Wolves in fundraising challenge
6 days ago
Lottery stalwart passes away.
7 days ago
Former Liverpool and England defender the star attraction
7 days ago
Former Wolves midfielder as busy as ever!
7 days ago


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You are mistaken. Natanyahu is not interested in all the territories, he is now riding on a sort Israeli consensus that aims to get as much land in the WB as possible with as little Arab population as possible, with all Jerusalem included (hoping to change its demography). This consensus includes Barak and possibly most of Kadima. Of course, the Palestinians know this and this is why they will not negotiate in these terms, and (most likely) there will not be a Palestinian state. Only firm action by the US government could challenge the policies of this consensus, but it's not happening and might not happen at all.
ISIS kills 22 in Yemen's Sanaa, Aden; targets both gov't and Houthi rebels (Reuters)
from the article: Barak, Mubarak talks to focus on coaxing Abbas to negotiating table


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This job posting is no longer available on Indeed.
Find similar jobs:Legal Assistant jobs
- Acstencia HR Solutions jobs
Position Name: LEGAL ASSISTANTEmployment Type: PERMANENT FULL TIMELocation: DOWNTOWN CALGARY
Job Overview:
A Calgary Law firm is looking for a Legal Assistant to work in their Corporate Commercial department in their downtown office.
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Legal Assistant Certification preferredCandidates should have 3+ years of relevant experience
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Highly organized and self-motivatedExcellent attention to detailKeen to learn new computer skills
Salary commensurate to experience
Ref: PLH1


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Cookie Policy
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Like many websites, we use cookies to provide enhanced functionality and track the usage of our websites with Google Analytics, and some of our third-party advertisers might use them to deliver adverts tailored to what they think you might be interested in.
Cookies are small text files that are stored on your computer by most of the websites you visit. Our cookies do not identify you, or store any personal information about you
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First published at 10:34, Friday, 11 May 2012
Published by http://www.newsandstar.co.uk
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Canal Street Grill Map
4500 W. Tropicana Ave. (Arville St.)
702-365-7111 | Make Restaurant Reservations | Menu
Find Canal Street Grill with this handy map to the restaurant. If you don't see a pop-up, click on the map's green arrow to get driving directions to and from Canal Street Grill.
Check out the 2015 edition of GAYOT's Annual Restaurant Issue, which features the Top 40 Restaurants in the US and more.


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Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
Completed Galladiator vs. Spenstar (reffed by TMR)
Discussion in 'ASB' started by TheMogRunner, Dec 13, 2011.
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Voluntary Organisations Bristol
(>500) for Voluntary Organisations in Bristol
Charity Search25 Portview RoadBS11 9LD Bristol Avonmouth0117 982 4060Closed
Charity Search provides a free service to individuals aged 50 and over, who are UK residents, by putting them in contact with charities that may wish to help them. Contact by letter, telephone ... charity, public interest, Charities Voluntary Organisations, Charitable Organisations, voluntary...
CARERS' SUPPORT CENTREVassall Centre, Gill AvenueBS16 2QQ Bristol Clifton0117 939 2562
Support, information and advice for carers in Bristol and South Gloucestershire. support for people caring for a family member or friend who is ill or disabled. ... voluntary organisations
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Studio Upstairs Art TherapyUnits 1 & 2 Albion Dockside Estate, Hanover PlaceBS1 6UT Bristol020 7503 1330Closed
Studio Upstairs is a place for people to express their talents through the art who for reasons of mental health difficulties or emotional distress, choose not. ... voluntary organisations
Addiction Recovery AgencyKings Court, King StreetBS1 4EF Bristol0117 930 0282Closed
... Voluntary Organisations, Leisure
Terrence Higgins Trust8-10 West StreetBS2 0BH Bristol Old Market0117 955 1000Closed
We offer a range of services throughout England, Scotland and Wales – many of them tailored to suit the varied needs of our diverse communities. Whatever your sexuality, HIV status, gender, cultural ... with HIV, sexual ill, sexual health, Voluntary Organisations, members, testing, health, tht,...
Emmaus (Bristol)Shaftesbury House, Kingsland RoadBS2 0QW Bristol0117 954 0886Closed
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Bristol Area Stroke FoundationThe Gatehouse Centre, Hareclive RoadBS13 9JN Bristol0117 964 7657
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Time2share2 Share, Unit 37 Easton Business Centre, Felix RoadBS5 0HE Bristol0117 941 5868
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Westbury Wildlife Park FoundationTrym RoadBS9 3ET Bristol Westbury On Trym0117 950 0439
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Dean Crescent Hostel Novas Scarman Group11, Dean Crescent, BedminsterBS3 1AG Bristol0117 987 2055
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The Richmond Fellowship80 Holloway RoadBS1 3DX Bristol020 7697 3300
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D A 2 Digital Art Development Agency59 Prince StBS1 4PH Bristol0117 914 6543
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Cystic Fibrosis Comfort FundP O Box 32BS99 1PT Bristol0117 949 6603
Cystic Fibrosis is one of the UK's most common, life-limiting, inherited diseases. Cystic Fibrosis affects the internal organs, especially the lungs and digestive system, by clogging them with thick ... Voluntary Organisations
Voice For The Child in Care36 Hotwell RdBS8 4UD Bristol0117 925 1368
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C P A-Centre For Performing ArtsDeanery RdBS1 5XN Bristol0117 925 5252
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Communities Organised For A Greater Bristol182 St Michaels HillBS2 8DE Bristol0117 970 6745
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The Black Carers Project20-22 Hepburn RoadBS2 8UD Bristol0117 941 5303
Bristol Black Carers supports carers and those whom they care for to access mainstream care and health related public services. We provide regular support group meetings, organise trips and activities ... Voluntary Organisations
C l i C12-13 King SqBS2 8JH Bristol0117 924 8844
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Lazio boss Vladimir Petkovic has named a 21-man squad for Thursday's Europa League tie against Panathinaikos.
Star striker Miroslav Klose is included, but reports suggest that he will be rested for the tie which should allow Sergio Floccari a spot in the starting XI.
First choice goalkeeper Federico Marchetti is missing because of injury.
Goalkeepers: Bizzarri, Scarfagna, Guerrieri.
Defenders: Biava, Ciani, Dias, Radu, Scaloni, Cavanda, Konko.
Midfielders: Cana, Ledesma, Onazi, Hernanes, Gonzalez, Candreva, Mauri.
Forwards: Kozak, Klose, Zarate, Floccari.
Check out OLBG.com's list of ££ Free Bets from UK bookmakers before placing your bets!


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Palm Springs in California is singing more than the blues this October, as Lesbian News puts the spotlight on the Palm Springs Women's Jazz Festival.
October signals a return to balance (think Libra). Read the Lesbian News October 2015 FEMASTROLOGY By Victoria Bearden and get your monthly horoscope.
The Tampa Bay International Gay and Lesbian Film Festival, one of the largest and longest-running independent gay film festival, is set to start tomorrow.
A remote village in the Dominican Republic harbors a rare genetic disorder where little girls turn into boys by the age of 12 called "guevedoces."
The United Nations has called on countries to end violence and discrimination against LGBTI people, while asking these states to repeal discriminatory laws.
Lesbian rights won a round against discrimination after a South Carolina student was allowed by her school to wear a t-shirt proclaiming she's a lesbian.