text:
Google's Nexus event, iPhone 6s Plus, Android tablets (MobileTechRoundup show #355)
Google filled more than an hour with near constant hardware and software news that Kevin and I used to kick off the latest MobileTechRoundup podcast.
Matthew Miller provides you with news, commentary and in-depth reviews of the latest in mobile gadgetry such as tablets, cutting edge smartphones, and portable gaming.
Google filled more than an hour with near constant hardware and software news that Kevin and I used to kick off the latest MobileTechRoundup podcast.
LG set the bar high with the first round Android Wear device and is now following it up with the first cellular-enabled model that also includes GPS.
The upcoming Google Pixel C has an elegant keyboard solution, but now Google needs to put some effort into getting tablet-optimized apps for the enterprise.
If you are looking for an Android tablet with a focus on media experiences, then I highly recommend the new LG tablet. It's a fantastic deal even if you never use the AT&T data services.
Android Wear is growing up and the current competition shows round can be appealing and valuable in improving your efficiency.
The Moto 360 was arguably the best smartwatch last year and the improved design, Moto Maker customization, and iOS functionality make this year's version even better.
Huawei just launched its first Android Wear device. The more traditional round watch design looks great and even works with your iPhone.
In order for people to start using smartwatches, they need to be able to touch, feel, and try them out. Carrier stores are a perfect location to reach customers and Apple will soon be putting the Apple Watch next to the iPhone.
Apple announced several new products last week and while we spent most of the podcast discussing them, we also talked about the new Moto X, Samsung tablet, and more.
I attempt to insert my microUSB cable in the wrong way on a daily basis. The MicFlip solves that problem and should be the cable all manufacturers include.
An integrated WiFi hotspot is an option on many new vehicles, but if you have an older vehicle ZTE and AT&T have a great, low-cost option for you to consider.
Jaybird is focused on bringing wireless audio to serious athletes, but its headphones are very expensive and lack the bass that is often desired at the gym.
Some people like chunky watches and find the Apple Watch too sleek. Add a Lunatik Epik case and band to bulk things up and protect your Apple Watch from bumps and scratches.
I've been on the hunt for a MOTOACTV successor for a couple of years and it looks like TomTom may finally have a sports watch to meet my GPS tracking and offline music needs.
Samsung continues to release Android tablets for Barnes & Noble under the Nook brand and the latest is the thinnest and lightest tablet yet.
Hands-on impressions of the Google Pixel C Android tablet: Optimized for work, apps need to follow
If your Kindle Fire is having issues, follow these instructions
Windows 10 on a Surface Pro 3: Six things I like, four I don't
Microsoft's Surface Pro 3 Docking Station and new Universal Mobile keyboard are key to my home office
Hands-on with the Huawei Watch: An elegant round Android Wear smartwatch for Android and iOS users

subset: commoncrawl


text:
Quarterly report | Aug 18, 15:21
Taiwan's handset shipments registered growth in second-quarter 2015 thanks to impressive increases in shipments from Asustek...
Display panels for wearable devices: Market overview and forecast through 2017
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Intel strategies in the mobile device market
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This Digitimes Research Special Report details Intel's mobile AP strategies, status, advantages, partnerships and operating...
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The global notebook market remained sluggish in the second quarter of 2015. The seasonal pattern that has governed the notebook market previously will not appear in 2015, with Taiwan makers set to see on-year declines in the shipments during the second half of the year.
Taiwan 2Q15 handset shipments up 18.6% on quarter
Jul 7, 14:48
Taiwan to ship 25.5 million handsets in 2Q15
May 4, 22:01
Taiwan 1Q15 handset shipments down 30.3% sequentially
Apr 23, 20:28
Global smartphone shipments in 2015 to reach 1.401 billion units
Mar 19, 22:42
Taiwan ready to develop smartphone payment system in 2015
Mar 13, 16:01
Development of Wi-Fi Only Phone service gaining momentum
Mar 12, 14:49
LG, Sony Mobile, Acer highlight entry-level, mid-range smartphones at MWC
Mar 11, 22:07
May 15, 15:58
Most of Taiwan's handset makers felt strong seasonal effects in the first quarter. Foxconn suffered particularly as a result of drastic drops in orders from Sony Mobile and Microsoft Mobile.
Taiwan digital cameras – 1Q 2015
Apr 28, 10:33
DSCs continue to be cannibalized by smartphones with increasingly better camera functions. Taiwan's DSC makers saw a short-lived rebound in shipments in fourth-quarter 2014, but slipped back to a downward trend...
Apr 24, 15:49
The retail market was unable to digest the massive inventory of inexpensive notebooks in first-quarter 2015. The result was drastic drops in orders from vendors for their Taiwan-based ODMs, who were hit by the...
Feb 13, 15:20
Smartphone shipments from Taiwan's brand vendors and manufacturers broke the 20-million mark in the fourth quarter of 2014, buoyed by strong demand from the end market and OEM clients.
Taiwan digital cameras – 4Q 2014
Jan 28, 10:51
Taiwan makers saw an on-year rise in DSC shipments during the fourth quarter of 2014, as driver IC shortages that had hampered their shipments in the previous quarter eased. But shipments for the entire 2014 continued...
Jan 21, 15:53
The notebook market saw significant demand for entry-level devices whose pricing levels were comparable to those of tablets in the fourth quarter of 2014, which maintained Taiwan ODMs' overall shipments at a level...
Nov 20, 10:53
Taiwan's top handset ODM Foxconn Electronics lost a significant amount of feature phone orders from Microsoft Mobile in the third quarter, while the biggest brand vendor HTC also saw a sharp decline in its shipments...
Taiwan digital cameras – 3Q 2014
Oct 30, 15:40
The global digital still camera (DSC) market continued to decline in the third quarter of 2014, a trend reflected by Taiwan makers' significant on-year shipment drops. Worldwide DSC shipments are expected to drop...
Oct 23, 11:55
US notebook brand vendors' stronger-than-expected sales fueled their Taiwan-based ODM partners' shipment growth in the third quarter. In general, the enterprise segment saw better shipment momentum than the consumer...
Jul 30, 09:17
HTC's launch of its new smartphone models shot up both its own shipments and the overall shipments from Taiwan's handset sector in the second quarter. Although own-brand shipments were strong, ODM shipments were...
Taiwan server shipment forecast and industry analysis, 2015
Apr 10, 15:57
The server market did not perform well in 2014 though rising demand from Internet data centers (IDCs) and China brands helped global shipments (measured by motherboards) grow 7.1% to 10.4 million. Using this as...
How China is shaping the LTE/TD-LTE market in 2015
Apr 9, 15:42
Digitimes Research estimates that the global LTE market doubled in size to 445 million users in 2014 and we further forecast that annual growth in the number of LTE users will remain above 70% between 2015-2016,...
High-brightness LED market trends and forecast, 2015
Mar 16, 17:50
Digitimes Research forecasts that in 2015, the global high-brightness (HB) LED industry will have annual growth of 7.5% in terms of output, reaching US$13.7 billion. The total number of LEDs used will reach 186...
2015 global AP market forecast and vendor analysis
Jan 23, 10:46
Digitimes Research estimates that total 2014 AP shipments will reach 1.52 billion units worldwide, up 19.6% from 2013, and in 2015 the global market will see shipments of 1.65 billion units, growing 8.5% on year...
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Wireless broadband developments in Southeast Asia markets
Nov 12, 10:53
As of 2013, the 10 ASEAN nations had a total of over 700 million mobile subscriptions, with the CAGR from 2003-2013 reaching 24%, and the share of the global user base rising from 4.9% to a high of 10.6%. This...
2014 global smartphone market forecast
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2014 global tablet demand forecast
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Digitimes Research estimates that in 2014 global tablet shipments will reach 289 million units. This report analyzes the main players, their strategies and shipments forecasts for 2014, as well as other factors...
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This Digitimes Research Special Report provides a 2015 forecast for the global tablet market and analyzes the strategies of key market players such as Google, Apple, Intel, and Microsoft.
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text:
May 2013
ISO 9001:2015, the essential standard for your quality management system is available for you to buy today
8 October 2015Our Cyber Security Conference aims to bring you the latest information on the trends and issues that Information and Cyber Security professionals face and what should be done to overcome these challenges.
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text:
FXV Athlete Combine testing Sat 17th October! Presented by Steve Buckley and the Force X Velocity crew. Why not compare yourself to your friends, other rep players and the NZ average?? Read more....
2016 Rep Trials Open NOW!!!!! How would you like to play for one of the most successful Basketball associations in New Zealand!!?? Sign up now and give it a go!!!
Applications for Representative Coaching Positions Now Open! Applications are now open for the 2016 Representative season. Click here to download the form and apply to become a part of New Zealand's leading basketball associ...
Term 4 3x3 Competition Grab your friends and enter our term 4 3x3 competition!!


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jun 11, 1985
|Filing date
|Sep 29, 1982
|Priority date
|Sep 29, 1982
|Fee status
|Publication number
|David Edgren
|Original Assignee
|Alza Corporation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (14), Referenced by (67), Classifications (8), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention pertains to both a novel and useful osmotic dispenser for dispensing a beneficial agent to an environment of use. More particularly, the invention relates to a wall comprising a semipermeable member and an enteric member for regulating the agent release from the dispenser in the environment of use. The invention concerns also a composition comprising a semipermeable member and an enteric member.
Osmotic therapeutic dispensers for the precision administration of drugs with control of their delivery patterns and with extended delivery times are known in U.S. Pat. No. 3,845,770 issued to patentee Theeuwes and Higuchi, and in U.S. Pat. No. 3,916,899 issued to the same patentee. The dispensers disclosed in these patents are made of a semipermeable wall that surrounds a compartment containing a drug. The semipermeable wall is permeable to the passage of an external fluid, impermeable to the passage of drug, and it has a portal for dispensing drug from the dispenser.
In U.S. Pat. Nos. 4,036,227; 4,093,708; 4,096,238; 4,135,54; and 4,142,526, all issued to patentee Zaffaroni, Michaels, and Theeuwes, an improvement is disclosed in the osmotic dispensers of U.S. Pat. Nos. 3,845,770 and 3,916,899. The improvement comprises an enteric layer, which does not disintegrate in the stomach but disintegrates in the intestine, coated onto the exterior surface of the semipermeable wall of the dispenser. The dispenser coated entirely with the enteric layer releases drug only in the intestine, and not in the stomach.
The above dispensers represent an outstanding and a pioneer advancement in the osmotic dispensing art, and they are useful for dispensing innumerable drugs to the environment of use. Now, it has been found the dispenser can be unexpectedly improved leading to more desirable results. For example, it will be appreciated by those versed in the dispensing art that if a novel and useful dispenser is made available for delivering drug at a rate or rates precisely controlled by the dispenser which rate or rates are in response to the biological environment within which it functions, such a dispenser would have a positive clinical value, and also represent a substantial contribution in the dispensing art.
Accordingly, it is an immediate object of this invention to provide a novel osmotic dispenser for dispensing a beneficial agent to produce a beneficial effect, which device is an improvement over the laminated devices associated with the prior art.
Another immediate object of the invention is to provide an osmotic dispenser comprising a wall which possesses the inherent property of self regulating its permeability in response to changes in the fluid environment of use.
Yet another object of the invention is to provide an osmotic device comprising a wall formed of a composition consisting essentially of a semipermeable member and an enteric member for controlling the release of agent from the device.
Still another object of the invention is to provide a composition of matter comprising a semipermeable member and an enteric member which composition is useful for forming the wall of an active agent dispenser.
Still yet another object of the invention is to provide an osmotic dispensing device that can dispense a beneficial agent at a rate, or rates, controlled by the dispenser which are in response to the biological environment within which the dispenser functions over time.
Other objects, features and advantages of the invention will be apparent to those skilled in the art from the detailed description of this specification, taken in conjunction with the drawings and the accompanying claims.
In the drawings, which are not drawn to scale, but rather are set forth to illustrate various embodiments of the invention, the Figures appear as follows:
FIG. 1 is a view of an osmotic therapeutic dispenser designed for orally delivering a beneficial drug;
FIG. 2 is a view of the osmotic therapeutic dispenser of FIG. 1 in opened section through 2--2 illustrating the internal compartment of the dispenser.
FIG. 3a is a profile of an osmotic dispenser showing its release rate characteristics in an acidic environment of use;
FIG. 3b is a graph illustrating the cumulative amount released in an acidic environment for an osmotic device provided by the invention;
FIG. 4a is a graph depicting the release rate in an alkaline environment for an osmotic device provided by the invention; and,
FIG. 4b depicts the cumulative amount released in an alkaline environment for an osmotic device.
Turning now to the drawings in detail, which are examples of osmotic dispensers provided by the invention, and which examples are not to be construed as limiting, one embodiment of an osmotic dispenser is seen in FIGS. 1 and 2 indicated by the numeral 10. In FIG. 1, dispenser 10 comprises a body 11 having a wall 12 that surrounds an internal compartment seen in FIG. 2. A passageway 13 in wall 12 connects the interior of osmotic dispenser 10 with the exterior of dispenser 10.
In FIG. 2, osmotic dispenser 10 of FIG. 1 is seen in opened section with a portion of wall 12 cut and turned for illustrating the internal structure of osmotic dispenser 10. Dispenser 10 comprises a composite wall formed of a semipermeable polymer and an enteric agent, which wall surrounds and forms internal compartment 14. Wall 12 of dispenser 10 comprises a semipermeable polymer that is permeable to the passage of an exterior fluid present in the environment of use, substantially impermeable to the passage of drug and other compounds present in compartment 14 or present in the environment of use, and an enteric agent that is substantially insoluble in gastric fluid and is substantially soluble in intestinal fluid. Wall 12 is formed of the composition comprising the semipermeable and enteric materials which materials are nontoxic to a host.
Compartment 14 houses a beneficial drug identified by dots 15 that is preferably soluble in an external fluid that enters compartment 14 and exhibits an osmotic pressure gradient across wall 12 against the external fluid. In another embodiment, drug 15 has limited solubility in the external fluid that enters compartment 14 and it is mixed with an osmotically effective compound 16, identified by dashes, that is soluble in the fluid and exhibits an osmotic pressure gradient across wall 12 against an external fluid. Compartment 14 optionally contains a non-toxic dye for identifying drug 15 and for making release of drug 15 visible to the unaided eye.
Osmotic dispenser 10 releases drug 15 contained in compartment 14 in the gastric region by fluid being imbibed into compartment 14 in a tendency towards osmotic equilibrium at a rate controlled by the permeability of composite, semipermeable-enteric wall 12, and the osmotic pressure gradient across wall 12 to continuously dissolve drug 15, which drug 15 is pumped from dispenser 10 through passageway 13 at a controlled and continuous rate over a prolonged period of time. That is, in the stomach fluid passes through the semipermeable polymer into the compartment to form a solution containing drug that is dispensed from the device into the stomach over time.
Osmotic dispenser 10 releases drug 15 contained in compartment 14 in the intestine by the operation described for the gastric region, and additionally by enteric composition being dissolved or leached from wall 12; thereby, increasing the permeability of the wall 12 and consequently controlling the continuous rate of release of drug 15 in the intestine.
Osmotic dispenser 10 releases drug 15 that has a limited solubility in the fluid and is mixed with an osmotically effective compound by imbibing fluid in the gastric region, or in the intestinal region, through wall 12 into compartment 14, in a tendency towards osmotic equilibrium, at a rate controlled by the permeability of wall 12 and the osmotic pressure gradient across wall 12, to continuously dissolve the osmotically effective compound in compartment 14, and form a solution containing drug 15, that is released from dispenser 10 through passageway 13 at a controlled and continuous rate over a prolonged period of time.
Osmotic dispenser 10 of FIGS. 1 and 2 can be made into many embodiments including the presently preferred embodiments for oral use. The oral system is useful for releasing in the gastrointestional tract either a locally or a systemically acting drug over a prolonged period of time. Osmotic, oral therapeutic dispenser 10 can have various conventional shapes and sizes such as round with a diameter of 1/8 inches to 9/16 inches, or it can be shaped like a capsule having a range of orally administrable sizes from triple zero to zero, and from 1 to 8, and the like.
In FIGS. 3a and 3b, release rate of drug versus time and cumulative amount of the drug released versus time are shown for an osmotic dispenser releasing in the acidic environment, such as in gastric fluid present in the stomach. In FIGS. 4a and 4b, the release rate of drug versus time and cumulative amount of the drug released versus time are shown for an alkaline environment, such as in intestinal fluid present in the intestine of the gastrointestinal tract.
While FIGS. 1 and 2 are illustrative of various osmotic dispensers 10 that can be made according to the invention, it is to be understood these dispensers are not to be construed as limitinng, as the dispensers can take a wide variety of shapes, sizees, forms, and performances adapted for delivering different drugs to different biological hosts and biological environments.
In attaining the objects, features, and advantages of this invention, it has now been found that an osmotic dispenser can be provided for dispensing drug in the gastrointestional tract comprising the stomach and the intestine according to the mode and the manner of the invention. The osmotic dispenser comprises a wall that surrounds and defines a compartment. The compartment contains a drug, and optionally an osmotically effective solute. There is a passageway in the wall for dispensing drug from the dispenser.
The wall of the osmotic dispenser is formed of a composite consisting essentially of materials that do not adversely affect the drug, the compound, or the biological environment. The wall is formed of a composition comprising a selectively permeable polymeric material and an enteric material that are homogenously, or heterogenously, blended or dispersed in a wall forming intimate operable relation to yield an osmotically functioning wall.
The selectively permeable polymers useful for manufacturing the semipermeable wall of the osmotic dispenser are represented by a member selected from the group consisting essentially of cellulose acylate; cellulose diacylate; cellulose triacylate; cellulose acetate; cellulose diacetate; cellulose triacetate; polyamides; polyurethanes; and the like. Suitable semipermeable polymers for manufacturing osmotic dispensers are disclosed in U.S. Pat. Nos. 3,845,770; 3,916,899; 4,008,719, 4,036,228; and 4,111,210. These patents are assigned to the ALZA Corporation of Palo Alto, Calif., the assignee of this patent application.
The enteric materials that can be blended with the semipermeable polymer for forming the wall of the dispenser are non-toxic enteric materials. The materials and their degradation products should be physiologically inactive, the enteric materials should not dissolve or disintegrate in the stomach during the time the dispenser remains in the stomach, and the enteric materials should disintegrate once the dispenser enters the intestine. The enteric materials suitable for the present invention include those materials digestible by enzymes in the intestinal tract, enteric materials containing an ionizable polyacid, frequently a long-chain polymer with ionizable carboxyl groups, and the like. Typical enteric materials include keratin; keratin sandarac-tolu; salol; salol β-naphthyl benzoate and acetotannin; salol with balsam of peru; salol with tolu; salol with gum mastic; salol and stearic acid; salol and shellac; formalized gelatin; formalized cross-linked gelatin and exchange resins; fatty acids; fats; waxes; fatty acid-wax mixtures; myristic acid-hydrogenated castor oil-cholesterol; stearic acid-mutton tallow; stearic acid-balsam of tolu; stearic acid-castor oil; shellac; ammoniated shellac; ammoniated shellac-salol; shellac-wool fat; shellac-cetyl alcohol; shellac-stearic acid-balsam of tolu; shellac-n-butyl stearate; abietic acid; methyl abietate; benzoin; balsam of tolu; sandarac; mastic with tolu; mastic with cetyl alcohol; cellulose acetate phthalate; cellulose acetate phalate with resinous carrier; cellulose acetate and shellac; starch acetate phthalate; polyvinyl acid phthalate; methylcellulose acid phthalate; hydroxypropyl methylcellulose phthalate; 2-ethoxy-5-(2-hydroxyethoxy-methyl)cellulose phthalic acid; acid phthalates of carbohydrates; zein; alkyl resin-unsaturated fatty acids-shellac; hippuric acid; ternary copolymers of styrene; copolymers of methacrylic acid and methylmethacrylate such as methacrylic acid-methylmethacrylate 50:50, and copolymer methacrylic acid-methylmethacrylate 30:70; copolymer hydrolyzed styrene-maleic anhydride; poly(methyl vinyl ether/maleic anhydride); carboxylated copolymer of vinyl acetate; colophony; mixtures of zein and carboxymethylcellulose; methyl cellulose acid phthalate; styrene-maleic acid monoester copolymer; styrene-maleic acid-maleic acid monoester terpolymers; partial esters of isopropyl poly(vinyl methyl ether/maleic anhydride); half esters of poly(ethylene/maleic anhydride); half esters of poly(vinyl methyl ether/maleic anhydride); precipitation, association, and polyelectrolyte polymers such as polyacrylic acid blended with polyvinyl pyrrolidone; polyacrylic acid with polyethylene oxide; methylvinyl ether maleic anhydride with polyvinyl pyrrolidone; calcium chloride with poly(acrylamide); aluminum sulfate with poly(acrylamide); amino acids of isoelectric point below pH7 comprising: alanine; aspartic acid; cystine; glutamic acid; glycine; isoleucine; leucine, methionine; phenylalanine; proline; sarconine; serine; threonine; tryptophene; tyrosine; valine; and the like. The amount of enteric material blended with the semipermeable polymer is about 0.5 wt% to 40 wt%. Typical enteric materials are discussed in Remington's Pharmaceutical Sciences, Thirteenth Ed., pages 604 to 605, 1965, published by Mack Publishing Co., Eaton, Penna., and in Biopharmaceutics and Relevant Pharmacokinetics, First Ed., page 158 to 165, 1971, published by Drug Intelligence Publications, Hamilton, Ill.
The expression passageway as used herein includes an aperture, orifice, bore, hole and the like through the wall. The expression includes also an erodible element in the wall such as a gelatin plug that erodes and forms a passageway in the environment of use. A detailed description of osmotic passageways, and the maximum and minimum dimensions for passageways are disclosed in U.S. Pat. Nos. 3,845,770 and 3,916,899.
Plasticizers are included optionally in the wall formulation to impart flexibility to it and to facilitate the dissolution and subsequent leaching of enterically-active members. Such plasticizers include triethyl citrate; tributyl citrate; tributyrin; butyl phthalyl butyl glycolate; triacetin; triethyl citrate; polyethylene glycol; acetyl triethyl citrate; tributyl citrate; acetyl tributyl citrate; acetyl tri-2-ethylhexyl citrate; sorbitol; glycerin; corn oil, castor oil; cotton seed oil; and the like.
The expression drug as used herein broadly includes any compound, composition of matter, drug formulation, or mixture thereof, that can be delivered from the dispenser to produce a beneficial and useful result. The term drug more specifically includes any substance that produces a local or a systemic effect in animals, avians, pises and reptiles. The term animal includes primates, humans, warm-blooded animals, sport and farm animals, dogs, cats, laboratory animals and the like. The drugs that can be delivered by the method of the invention include inorganic and organic drugs, such as central nervous system acting drugs, hypnotics, sedatives, psychic energizers, tranquilizers, antisteroids, laxatives, antideprressants, anti-convulsants, muscle relaxants, antiparkinson agents, anesthetics, antiinflammatory agents, antimalarials, hormones, sympathomimetics, antibiotics, diuretics, antiparasitics, neoplastics, hypoglycemics, nutritionals, and the like. Representative of specific drugs include aminobarbital, aminophylline, aminosalicylic acid, ammonium biphosphate, ammonium chloride, amylase, anti-histamine, aspirin, atropine sulfate, avazyme, choledyl, chymoral, chymoral-100, chymotrypsin, diasone sodium, diethylstilbestrol, E-mycin, erythromycin, ephedrine hydrochloride, ferrous sulfate, gentian violet, hemicellulase, hydralazine, hyoscine hydrobromide, hyoscyamine sulfate, ilotycin, lipase, methenamine mandelate, orenzyme, ox-bile extract, oxtriphylline, pancreatin, papain, phenobarbital, potassium chloride, potassium iodide, potassium thlocyanate, quinidine sulfate, robimycin, sodium aminobenzoate, sodium biphosphate, sodium chloride, sodium salicylate, sodium secobarbital, stilbestrol, stilbetin, sulfasalazine, thyroid, and urethan. The amount of drug present in a dispenser will vary depending on the activity and the amount of drug to be administered to the host. Generally, the osmotic dispenser will be from 0.05 mg to 3 g or more, with individual dispensers containing for example 5 mg, 25 mg, 50 mg, 125 g, 250 mg, 500 mg, and the like. The drug can be in the dispenser in various forms such as dispersion, granule, powder, pressed mass, film, and the like. The beneficial drugs and their present doses are known to the dispensing art in Pharmaceutical Sciences, by Remington, 15th Ed., 1975, published by Mack Publishing Co., Easton, PA; The Drug, The Nurse, The Patient Including Current Drug Handbook, 1974-1976, by Falconer, et al., published by Saunder Company, Philadelphia, PA; in Physician Desk Reference, 33rd Ed., 1979, published by Medical Economics, Oradell, NJ, in Ann. of Allergy, Vol. 41, pages 75 to 77, 1979; in Arzneim. Forsch., Vol. 25, pages 1629 to 1935, 1975; and in J. Inter. Med. Res., Vol. 7, pages 335 to 338, 1979.
The expression "osmotically effective compound" as used herein, includes inorganic and organic compounds that are effective solutes that exhibit an osmotic pressure gradient across the wall of the dispenser against an external fluid. The osmotic solutes are conveniently used by homogenously or heterogenously mixing a solute with the active drug in the compartment of the dispenser. In operation, these solutes osmotically attract fluid into the dispenser to produce a solution of the solute which is osmotically released from the device concomitantly transporting therewith dissolved and undissolved drug. Various osmotically effective solutes include compounds such as magnesium sulfate, magnesium chloride, sodium chloride, lithium chloride, potassium sulfate, sodium sulfate, potassium chloride, potassium acid, mannitol, urea, inositol, magnesium succinate, raffinose, sucrose, glucose, and the like. The osmotic solute preferably is initially in excess, and it can be in any suitable physical form such as particles, crystals, pellets, granules, and the like. The amount of osmotic solute in a dispenser is about from 0.5 mg to 500 mg, or more.
The osmotic dispenser of the invention is manufactured by standard techniques. For example, in one embodiment, the drug is mixed with other ingredients by ballmilling, calendering, stirring, and pressing into a preselected shape. The materials forming the wall and blended into a composition and applied by dipping, molding, or spraying the pressed drug core. One procedure for applying the wall is the air suspension technique. The air suspension technique can be used for manufacturing a wall as described in U.S. Pat. No. 2,799,341; in J. Am. Pharm. Assoc. Vol. 48, pages 451 to 459, 1959; and J. Am. Pharm. Assoc. Vol. 49, pages 82 to 84, 1960.
The solvents used for forming the wall include water, ketones, esters, ethers, alcohols, aliphatic hydrocarbons, halogenated solvents, cycloaliphatics, aromatics, heterocyclic solvents, and mixtures thereof. Typical solvents include acetone, diacetone, methanol, ethanol, isopropyl alcohol, methyl isobutyl ketone, n-heptane, methylene, dichloride, ethylene dichloride, mixtures such as acetone and water, ethanol and water, acetone and ethyl alcohol, methylene dichloride and methanol, ethylene dichloride and methanol, and the like.
The following example is merely illustrative of the present invention, and it should not be considered as limiting the scope of the invention in any way, as this example and other equivalents thereof will become apparent to those versed in the art in the light of the present disclosure, the drawings and the accompanying claims.
An osmotic dispenser for the delivery of the beneficial drug hydralazine hydrochloride is manufactured as follows: a drug formulation is prepared for housing in the compartment of the dispenser by forming drug cores weighing 275 mg and consisting of the drug present as 18.2 wt% hydralazine hydrochloride, 75.9 wt% mannitol, 2.9 wt% hydroxypropyl methylcellulose, and 3 wt% stearic acid, which were blended into a homogenous formulation and a precompartment formed by compressing the mass in a 3/8 inch standard concave punch in a Manesty press at 1.5 ton pressure head.
Next, the compressed drug core is placed in an air suspension coating machine and coated with a semi-permeable-enteric composition consisting of 35 wt% cellulose acetate having an acetyl content of 39.8%, 35 wt% cellulose acetate having an acetyl content of 32.0%, with an enteric composition consisting of 15 wt% hydroxypropyl methyl cellulose phthalate grade 50 and 15 wt% triacetin. This composition is applied from a solution of 5 wt% solids in a solvent system consisting essentially of 1900 g methylene chloride and 1900 g methanol. The dispensers are coated to a wall weight of approximately 19 mg and are dried in an air oven at 50� C. A 10 mil passageway is laser drilled through the wall to complete fabrication of the osmotic dispenser.
In FIG. 3a, the dispenser is shown releasing in gastric fluid at an average rate of approximately 0.5 mg/hr. The measured delivery rate of this dispenser, as depicted in FIG. 4a, when operating in intestinal fluid rises six fold to a rate of approximately 3 mg/hr. The cumulative rate in gastric fluid is seen in FIG. 3b, and the cumulative rate in intestinal fluid is seen in FIG. 4b. Systems identical to these but manufactured with nonenteric members consisting of 15 wt% hydroxypropyl methylcellulose grade 606 and 15 wt% polyethylene glycol 4000 grade 4000 substituted for the enteric composition in this cellulose acetate wall release in gastric fluid and in intestinal fluid at the same rate.
|Cited Patent
|Filing date
|Publication date
|Apr 22, 1969
|Nov 3, 1970
|Merck & Co Inc
|Controlled release medicinal tablets
|Jun 5, 1972
|Nov 5, 1974
|Alza Corp
|Osmatic dispensing device for releasing beneficial agent
|Feb 7, 1974
|Nov 4, 1975
|Alza Corp
|Osmotic dispensing device with maximum and minimum sizes for the passageway
|Feb 2, 1976
|Feb 22, 1977
|Alza Corporation
|Osmotic system having laminar arrangement for programming delivery of active agent
|Dec 23, 1974
|Jul 19, 1977
|Alza Corporation
|Osmotic releasing device having a plurality of release rate patterns
|Sep 11, 1975
|Jul 19, 1977
|Alza Corporation
|Osmotic dispenser with gas generating means
|Jul 8, 1974
|Apr 11, 1978
|Byk Gulden Lomberg Chemische Fabrik Gmbh
|New oral form of medicament and a method for producing it
|Mar 9, 1977
|Jun 6, 1978
|Alza Corporation
|Osmotic releasing device having a plurality of release rate patterns
|Mar 9, 1977
|Jun 20, 1978
|Alza Corporation
|Method for administering drug to the gastrointestinal tract
|Nov 22, 1976
|Sep 5, 1978
|Alza Corporation
|Osmotic system for delivering selected beneficial agents having varying degrees of solubility
|Mar 9, 1977
|Jan 23, 1979
|Alza Corporation
|Osmotic releasing system for administering ophthalmic drug to eye of animal
|Mar 9, 1977
|Mar 6, 1979
|Alza Corporation
|Osmotic releasing system with means for changing release therefrom
|Jun 14, 1982
|Nov 15, 1983
|Sterling Drug Inc.
|Sustained-release pharmaceutical tablet and process for preparation thereof
|Jun 30, 1982
|Mar 20, 1984
|Dr. Karl Thomae Gmbh
|Bromhexine delayed-release pharmaceutical form
|Citing Patent
|Filing date
|Publication date
|Apr 22, 1985
|Sep 2, 1986
|Alza Corporation
|Osmotic device comprising means for governing initial time of agent release therefrom
|Aug 9, 1985
|Oct 21, 1986
|Alza Corporation
|Device for administering calcium ascorbate
|Feb 1, 1985
|Aug 11, 1987
|Merck & Co., Inc.
|Lipid osmotic pump
|Oct 26, 1984
|Sep 15, 1987
|Alza Corporation
|Colon delivery system
|Nov 25, 1985
|Jan 5, 1988
|Eastman Kodak Company
|Rumen-stable pellets
|Sep 17, 1984
|Jan 26, 1988
|Alza Corporation
|Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use
|Jan 7, 1987
|Jun 14, 1988
|Alza Corporation
|Composition comprising salbutamol
|Jan 8, 1987
|Oct 11, 1988
|Alza Corporation
|Constant release system with pulsed release
|Jan 29, 1988
|Jul 25, 1989
|Alza Corporation
|Composition comprising a therapeutic agent and a modulating agent
|Mar 16, 1987
|Jul 25, 1989
|Alza Corporation
|System for delivering drug in selected environment of use
|Apr 1, 1988
|Aug 15, 1989
|Alza Corporation
|Chlorpheniramine therapy
|Mar 16, 1987
|Sep 5, 1989
|Alza Corporation
|Intestine drug delivery
|May 7, 1990
|Mar 2, 1993
|Alza Corporation
|Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
|Mar 5, 1992
|Mar 9, 1993
|Alza Corporation
|Dosage form for treating central nervous system disorders
|Jun 17, 1991
|Jun 22, 1993
|Alza Corporation
|Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
|Feb 25, 1993
|Oct 25, 1994
|Pfizer Inc
|PH-triggered osmotic bursting delivery devices
|Feb 21, 1991
|Jan 3, 1995
|University Of Kentucky Research Foundation
|Sustained release drug delivery devices
|Oct 19, 1994
|Mar 11, 1997
|Pfizer Inc.
|PH-triggered osmotic bursting delivery devices
|Aug 28, 1997
|May 11, 1999
|Control Delivery Systems, Inc.
|Sustained release drug delivery devices
|Apr 13, 1995
|May 30, 2000
|Pfizer Inc.
|Controlled-release dosage forms of Azithromycin
|Mar 20, 1998
|Aug 8, 2000
|Andrx Pharmaceuticals, Inc.
|Controlled release oral tablet having a unitary core
|Aug 31, 1998
|Aug 8, 2000
|Andrx Corporation
|Oral dosage form for the controlled release of a biguanide and sulfonylurea
|Mar 24, 1993
|Apr 17, 2001
|Alza Corporation
|Antiparkinson dosage form
|Jun 9, 2000
|Sep 4, 2001
|Andrx Pharmaceuticals, Inc.
|Controlled release tablet having a unitary core
|Apr 26, 2000
|Apr 23, 2002
|Control Delivery Systems, Inc.
|Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
|Nov 1, 2001
|Dec 17, 2002
|Andrx Pharmaceuticals, Inc.
|Controlled release oral tablet having a unitary core
|Nov 3, 2000
|Sep 14, 2004
|Andrx Labs, Llc
|Methods for treating diabetes via administration of controlled release metformin
|Jun 9, 2000
|Dec 6, 2005
|Mochida Pharamceutical Co., Ltd.
|System for release in lower digestive tract
|Mar 9, 2001
|Sep 19, 2006
|Pfizer Inc
|Controlled-release dosage forms of azithromycin
|Jul 6, 2004
|Feb 26, 2008
|Durect Corporation
|Osmotically-driven fluid dispenser
|Mar 2, 2007
|Apr 5, 2011
|Andrx Labs, Llc
|Controlled release metformin formulations
|Apr 22, 2002
|Jul 26, 2011
|Lts Lohmann Therapie-Systeme Ag
|Gastric juice-resistant device for releasing mucoadhesive active substance excipients, and method for producing this gastric juice-resistant device
|Dec 12, 2007
|Feb 7, 2012
|The Invention Science Fund I, Llc
|Medical or veterinary digestive tract utilization systems and methods
|Jan 8, 2010
|Aug 28, 2012
|Psivida Us, Inc.
|Method for treating and/or preventing retinal diseases with sustained release corticosteroids
|Nov 29, 2007
|Nov 6, 2012
|The Invention Science Fund I, Llc
|Medical or veterinary digestive tract utilization systems and methods
|Dec 17, 2007
|Dec 18, 2012
|The Invention Science Fund I, Llc
|Medical or veterinary digestive tract utilization systems and methods
|Mar 21, 2011
|Jul 2, 2013
|Andrx Labs, Llc
|Controlled release metformin formulations
|Sep 15, 2009
|Oct 8, 2013
|Iycus, Llc
|Anti-diabetic combinations
|Jan 19, 2010
|Nov 5, 2013
|Psivida Us, Inc.
|Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
|Jan 15, 2010
|Nov 5, 2013
|Psivida Us, Inc.
|Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
|Feb 16, 2006
|Mar 25, 2014
|Andrx Labs, Llc
|HMG-CoA reductase inhibitor extended release formulation
|Oct 31, 2007
|Apr 29, 2014
|The Invention Science Fund I, Llc
|Medical or veterinary digestive tract utilization systems and methods
|Nov 27, 2007
|Jul 29, 2014
|The Invention Science Fund I, Llc
|Medical or veterinary digestive tract utilization systems and methods
|Dec 13, 2007
|Aug 19, 2014
|The Invention Science Fund I, Llc
|Medical or veterinary digestive tract utilization systems and methods
|Oct 23, 2007
|Aug 19, 2014
|The Invention Science Fund I, Llc
|Adaptive dispensation in a digestive tract
|Nov 13, 2003
|Oct 28, 2014
|Psivida Us, Inc.
|Injectable sustained release delivery devices
|Mar 13, 2013
|Apr 7, 2015
|Alza Corporation
|Methods and devices for providing prolonged drug therapy
|Aug 12, 2003
|May 12, 2015
|Alza Corporation
|Methods and devices for providing prolonged drug therapy
|Mar 13, 2013
|Sep 29, 2015
|Alza Corporation
|Methods and devices for providing prolonged drug therapy
|Apr 22, 2002
|Jul 15, 2004
|Despina Solomonidou
|Gastric juice-resistant device for releasing mucoadhesive active substance excipients, and method for producing this gastric juice-resistant device
|Aug 12, 2003
|Feb 3, 2005
|Alza Corporation
|Methods and devices for providing prolonged drug therapy
|Sep 14, 2004
|Mar 3, 2005
|Avinash Nangia
|Controlled release composition with semi-permeable membrane and poloxamer flux enhancer
|Sep 14, 2004
|Mar 10, 2005
|Avinash Nangia
|Pharmaceutical composition with sodium lauryl sulfate as an extra-granular absorption/compression enhancer and the process to make the same
|Oct 21, 2004
|May 5, 2005
|Andrx Labs, Llc
|Decongestant and expectorant tablets
|Jul 15, 2005
|Nov 10, 2005
|Yumio Kudo
|System for release in lower gastrointestinal tract
|Jul 29, 2004
|Dec 29, 2005
|David Wong
|Extended release oxybutynin formulation
|Sep 13, 2005
|Jan 12, 2006
|Andrx Corporation
|Controlled release metformin compositions
|Sep 13, 2005
|Jan 12, 2006
|Andrx Corporation
|Controlled release metformin compositions
|Apr 29, 2005
|Feb 16, 2006
|Andrx Labs, Llc
|Controlled release metformin compositions
|Feb 16, 2006
|Jun 29, 2006
|Andrx Labs Llc
|HMG-COA reductase inhibitor extended release formulation
|Mar 1, 2005
|Sep 7, 2006
|Jenkins Richard B
|Medicament having coated methenamine combined with acidifier
|Aug 7, 1986
|Feb 12, 1987
|Alza Corp
|Abgabevorrichtung zur freisetzung von calciumascorbat
|Oct 30, 2001
|Nov 22, 2006
|Andrx Labs, LLC
|Controlled release compositions of biguanide with less side effects and treatment regimen thereof
|Mar 19, 1999
|Aug 12, 2009
|Andrx Corporation
|Controlled release oral tablet having a unitary core
|Sep 19, 2003
|Jun 19, 2013
|Andrx Labs Llc
|Novel pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
|Oct 18, 1999
|Apr 27, 2000
|Biotech Australia Pty Ltd
|Systems for oral delivery
|Dec 8, 2014
|Jun 11, 2015
|Durect Corporation
|Compositions comprising antioxidant, fluid dispensers, and methods involving the same
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Feb 25, 1985
Owner name: ALZA CORPORATION, A CORP OF CA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:EDGREN, DAVID;REEL/FRAME:004364/0762
Effective date: 19820927
|Dec 2, 1988
|Fee payment
Year of fee payment: 4
|Sep 28, 1992
|Fee payment
Year of fee payment: 8
|Sep 30, 1996
|Fee payment
Year of fee payment: 12


text: 10 Photographers That Should Shoot Lindsay Lohan For Playboy By Nick Schonberger Former deputy editor. Arsenal supporter. Follow Nick on Google+ 0 0 Watch Now Tags: Galleries, Lists, Girls, Lindsay Lohan, Photography, Playboy, Art & Design Like Us on Facebook Follow Us on Twitter Related Stories 10 Playboy Covers That Struck Up Controversy


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Yes they will, frumpy. My friend has just sent me a picture of his latest tulip to flower called " Helmar".
Too hot to work outside any more but i took some pics.
Potted on my new perennials and my small shrub I bought on Saturday and decorated one corner of the potager with them and three other I brought on from small plants I bought last year - Centaurea montana "Jordy" Dark Plum heuchera and a dark flowered sedum spectabile. The first flowers of the white Spanish bluebells are opening and the perfume from my amelanchier flowers is lovely even though only three have opened so far. Too bright to take pics at moment and getting quite warm.
Cloudier and cooler this morning but still dry and promises to be a good gardening day. I may take all the gazanias out of the cold frame now they are showing new growth and put lots of things from the conservatory to harden off. This should make more room for more seed sowing in there.
I am planning on potting up my three large perennials I bought on Saturday and taking them up to the potager to help decorate it. Then on Wednesday I hope to find places for my six sempervivums. We have a plant sale for the group funds at the AGm of the Alpine Gardening Society on Friday so will see what I can find for that too. Busy time in the garden but in good weather like this there is nowhere I would rather be. I may even start tidying up my patios and seating areas for my open day in May.
Nice hosta, flumpy. To make your sweet peas look tidier you could pinch the stem off down to the top pair of leaves. They look like they are starting to bush out.
Beautiful time of year Fruitcake. Some plants say farewell till next year so elegantly like these tulips and hyacinths. Heucheras never say goodbye.
Full steam ahead this lovely Monday morning. I could not resist snapping the first two flower panicles on my amelanchier now over four feet tall (it came as a one foot stick freebie). Also my dwarf rhodo with green flowers and my more exotic daffodils are beginning to flower too. But this morning's work is my coffee table up the potager.
Hooray! My new Bristol wheelbarrow ordered on Friday has arrived! Itching to have a go at putting it together but today is planned!
Another lovely week for gardening lies ahead. Today I shall pot up my three new alpines from their 1 litre plastic pots into pretty terracotta half pans and also the dwarf alpine heuchera which I bought in a 9cm pot. They shall have pride of place in the potager on the table in the centre where I put my coffee flask when I am working there. We decided the amelanchier trees on offer were too big to go in the car and did not buy one which is a blessing as the freebie one i thought was dead is anything but. it has leaves and flowers coming and is twice the size it was last year. I will get a pic when its buds open. Its berries are loved by the birds and me as they are very sweet. As I have quite a few bags of good compost now I will fill my four oblong woven baskets I bought last year with bulbs and compost to fill them and used all summer for gazanias with fresh compost and plant up afresh. Most of my gazanias are huge plants now having come unscathed through the winter so will plant them in the borders, big clumps of them where they get full sun.


text:
Oklahoma City Thunder v Cleveland Cavaliers
Dion Waiters of the Cleveland Cavaliers looks to pass the ball... News PhotoBall,Basketball - Sport,Cleveland - Ohio,Cleveland Cavaliers,Dion Waiters,Kevin Martin,Looking,NBA Pro Basketball,Ohio,Oklahoma City Thunder - Basketball Team,Passing - Sport,Quicken Loans Arena,Sport,USA,VerticalPhotographer Gregory ShamusCollection: National Basketball Association 2013 NBAECLEVELAND, OH - FEBRUARY 2: Dion Waiters #3 of the Cleveland Cavaliers looks to pass the ball against Kevin Martin #23 of the Oklahoma City Thunder at The Quicken Loans Arena on February 2, 2013 in Cleveland, Ohio. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and/or using this Photograph, user is consenting to the terms and conditions of the Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2013 NBAE (Photo by Gregory Shamus/NBAE via Getty Images)


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Tourism leads to more people choosing to live permanently in their vacation destinations, which is a key factor in the economy of North and South Carolina, particularly in coastal areas like Brunswick County.
That's what Patrick Mason, co-founder of the Center for Carolina Living, said at last week's Joint Economic Growth Summit at UNC Wilmington. And if an economic forecaster's prediction of an economic turnaround is correct, 2010 is a good time for
Brunswick County to capitalize on this trend.
All public bodies in North Carolina are subject to the N.C. Open Meetings Law, N.C. General Statute 143-318.11.
A public body is defined by N.C. General Statute as "any elected or appointed body, committee, commission, board or other group that is composed of two or more members who are authorized to exercise legislative, policy-making, quasi-judicial, administrative or advisory functions."
Brunswick County Animal Services is reviving a volunteer program, this time to assist with follow-up of its spay-neuter program.
David Swain, director at the county animal shelter on Green Swamp Road (N.C. 211) said about 20 people have offered to help.
"So I've got plenty right now for what we have," he said.
March 8 was the cutoff date for people interested in participating to submit names.
Swain is compiling a list he hopes to have in place this week.
CALABASH—Fire Chief Randy Bork has a list of items a recently bestowed grant will be used to buy for the Calabash Fire Department.
That's because the $132,335 U.S. Department of Homeland Security's Federal Emergency Management Agency (FEMA) Assistance to Firefighters Grant has a built-in earmark for how it's to be spent.
Brunswick County commissioners have informally agreed to help move forward efforts to secure a commercial fishing resource site next to the new Oak Island bridge.
The approval comes with a stipulation local fishermen will need to form their own nonprofit organization, because the county doesn't want to get involved in the commercial fishing industry.
A majority of fishermen voting at a recent meeting in Bolivia indicated they favor establishing the site next to the new Oak Island bridge.
BOVLIA—Two county commissioners and two county administrators will meet with officials from Southeastern Center for Mental Health and New Hanover County to discuss a funding agreement for Southeastern's proposed new administrative building.
Commissioners on Monday appointed commissioners Phil Norris and Charles Warren to join county manager Marty Lawing and assistant county manager Steve Stone to discuss with New Hanover and Southeastern officials Brunswick County's future share of the news 25,000-square-foot facility proposed by Southeastern.
CAROLINA SHORES—Larry and Cherry Thurman loved building and retiring to their new home on a cul-de-sac overlooking a pond two-and-a-half years ago.
But an abundance of recent rain has brought the water a little too close for comfort in the backyard in the Village at Calabash community.
Since January, rising water from the 5-acre retention pond has spilled into their yard. Because the pond has no drainage system, the water hasn't ebbed and continues to stand just a few feet from their house.
Four of the stories in "A Better Man: True American Heroes Speak to Young Men on Love, Power, Pride and What it Really Means to Be a Man," came to life Monday at Odell Williamson Auditorium.
Ron Johnson, Rusty Petrea, Tim Seibles and Leighton Smith came to Brunswick County to share stories of how they became better men. They gave words of advice and encouragement that could benefit anyone—man or woman.
BOLIVIA—Legal counsel for the Brunswick County Board of Education is recommending a policy change, which will no longer require drug testing of potential employees.
Brunswick County Schools currently requires all potential employees to pass a drug test, and other employees may be randomly tested upon suspicion.
BOLIVIA—Brunswick County Schools officials are considering relinquishing the Pre-K program from all district elementary schools and giving the available slots to private sectors in an attempt to save the district money during the next fiscal year.
Faye Nelson, director of instructional and accountability services, presented the idea to members of the Brunswick County Board of Education at a finance committee meeting Tuesday afternoon.
Copyright © 2015
The Brunswick Beacon is your source for local news, sports, events and information in Brunswick County, North Carolina and surrounding areas.


text:
Bonds wants to finish career in San Francisco
Updated: August 21, 2006, 8:38 PM ETAssociated Press
SAN FRANCISCO -- Barry Bonds' preference is simple: He wants to finish his career with the Giants.
"My choice is not to leave San Francisco." Barry Bonds
"That's my choice and you guys make it sound like it's our decision," Bonds said to reporters before Sunday's series finale against the Los Angeles Dodgers. "We don't make the final decision."
Given the day off after playing Friday and Saturday nights,
Bonds discussed a number of issues as he sat in ...
Read full story
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The RJ45 Cat 5e patch is perfect for use with 10/100 Base-T networks.
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Perfect for connecting audio sources (iPod, MP3, DVD,PC, and XM or Sirius satellite radio players) to an amplifier or home theater system, the Stellar Labs Value Series 3.5mm to dual RCA stereo cables feature bonded wires and tangle-free construction to help facil...
24-12186 - 6Ft Stereo Y-Cable RA 3.5mm TRS To Dual RCA
Stereo Breakout, Right-Angle 3.5MM TRS to Dual RCA - 6'This cable is designed to connect a digital audio player to a stereo system. It is ideal for connecting an iPod®, laptop, or similar device to a hi-fi receiver.
As always, MCM came through with great pricing on quality products.......


text:
They may offer quick and low-cost care, but how do retail clinics compare to other health care options in terms of quality?
Find Top-Rated Flower Mound Urgent Care Centers
Angie's List helps you hire the best - and avoid the rest!
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Local Articles in Flower Mound
The H1N1 symptoms are virtually the same as other seasonal-flu symptoms. So when should you contact your physician? Learn more from two highly rated doctors who are rated on Angie's List.
The American Ambulance Association partners with a software firm to create a system that uses a personal identification number to allow emergency workers to access patient health information.
Ask questions to learn more about your doctor, like how he or she treats preexisting conditions, handles emergencies during off hours, and about their education and residency background.
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With two new "Stagefright" vulnerabilities discovered, almost every Android device ever released is vulnerable to malicious hackers. Fixing the bug isn't simple.
Better photo tech should help Google's Android-powered phones escape the techie buyer niche. Too bad there's no image stabilization.
Apple's entry-level phone offers something unique. But is it too old?
VW's rapidly mushrooming diesel emissions conundrum could cost it up to $86B, argues major financial services company Credit Suisse.
The Korean electronics maker hopes the big V10 marks the start of a family of smartphones, akin to its G line.
A chip implanted in new cards is designed to stop cybercrime. Starting Thursday, stores that haven't upgraded their card-reading terminals will be on the hook for fraudulent charges.
Microsoft's new OS clipped off a 6.6 percent slice of desktop OS traffic in September as measured by Web tracker NetMarketShare, just a small increase from August.
The new smartphone features an independent second screen, while the smartwatch can be used as a phone.
Device maker offers a glimpse of its first smartphone to run on Google's Android software.
If you're in the market for a lightweight, swanky messenger bag, Waterfield Designs' Vitesse Messenger should be on your short list. It's made out of water-resistant waxed canvas and leather and comes in three color options for $159.


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BLACKSBURG, S.C. — The Rutherford Institute has come to the defense of a 73-year-old Virginia resident who was allegedly ordered by a park ranger to remove his car from a national military park in South Carolina because of political messages attached to his vehicle.
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Based in Beverly Hills, Gemelli caters to the high-class business traveler who appreciates the finer things in life. Founded in 1998, this European-style men's clothing brand is known for the flattering "Gemelli fit" of its cut-away collar dress shirts, constructed from authentic Italian cotton in an array of dreamy hues or bold stripes. Match your Gemelli button-down with one of the label's chic wool jackets and step out on the town in high style.
Embrace the blues with head-to-essentials by AG Adriano Goldschmeid, Fred Perry, and more
A smart selection of wardrobe staples for the season ahead
Need-them-now shorts by Gant Rugger, Publish Brand, Brooks Brothers, and many more
Back-to-campus classics, featuring Smart Turnout's clever closet staples and accessories


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Book your room at Gion Fukuzumi Inn
Get an overview of this hotel3.5-star Kyoto ryokan in Gion, walk to Gion Corner
Located in Gion, this ryokan is within a 10-minute walk of Kyoto Gion Lamp Museum and Gion Corner. Kiyomizu Temple and Heian Shrine are also within 1 mi (2 km).
Property Features
A spa tub, self parking, and laundry facilities are available at this ryokan. WiFi in public areas is free.
Room Amenities
All 23 rooms provide refrigerators, separate bathtubs and showers, and digital TV. Other amenities available to guests include free bottled water, hair dryers, and phones.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Gion Fukuzumi Inn features a spa tub and laundry facilities. Public areas are equipped with complimentary high-speed wireless Internet access. Parking is available onsite for a surcharge.
- Total number of rooms - 23
- Number of floors - 6
- Free WiFi
- Laundry facilities
- Self parking (surcharge)
- Number of buildings/towers - 1
- Spa tub
Family Friendly Amenities
- Free Wi-Fi
- Laundry facilities
- Refrigerator
Available in some public areas: Free WiFi
Self parking (surcharge)
Room Amenities
- Air conditioning
- Phone
- Free bottled water
- Refrigerator
- Private bathroom
- Hair dryer
- Slippers
- Separate bathtub and shower
- Blackout drapes/curtains
- Digital TV service
Hotel Policies
Check-in time starts at 4 PM
Check-out time is 10 AM
Payment types
Children and extra beds
- Children are welcome.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
No cribs (infant beds) available
No pets or service animals allowed
Optional extras
- Self parking fee: JPY 2000 per night
We should mention
The Japanese Ministry of Health, Labour, and Welfare requires all international visitors to submit their passport number and nationality when registering at any lodging facility (inns, hotels, motels, etc. ). Additionally, lodging proprietors are required to photocopy passports for all registering guests and keep the photocopy on file. No pets and no service animals are allowed at this property.


text:
Hawaii officer finds his blood runs blue, just like dad
By Leila Fujimori
The Honolulu Star-Bulletin
HONOLULU, Hawaii — Robby Robinson hadn't planned on following his dad's career path. In college on a baseball scholarship, he contemplated a career in teaching or coaching.
"I never wanted to be a policeman," he said.
Copyright © 2013 LexisNexis, a division of Reed Elsevier Inc. All rights reserved.
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Full story: Hawaii officer finds his blood runs blue, just like dad
Recommended Patrol Issues
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text:
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Guillermo Diaz: Pinup Boy
Two years ago Guillermo Díaz was invited to a party for Pinups, a gay magazine that features one pictorial a month, a matter-of-fact portrayal of a regular guy hanging out naked. "I'd never heard of the magazine," recalls Díaz, who met Pinups' creator and resident photographer, Christopher Schulz. "I was like, 'When are you going to shoot me?' And he asked, 'You want to do it?' I said, 'Yeah, let's do it. I want to be naked in a magazine.' "
So, TV career be damned, he did it.
It's pretty much how Díaz has approached his career from the beginning. Whether acting in mid-1990s indie films like Party Girl and Stonewall or, more recently, playing drug dealer Guillermo on Weeds and Angel, the gay nurse on NBC's short-lived hospital series Mercy, Díaz has gone with his gut, picking roles that grab him. And if they play into stereotypes or upend them, it's all part of a long career he hopes will be filled with, in his words, "emotionally crippled characters." He explains, "That's what I want to do. Dark, fucked-up characters have so much more going on than the hot guys. That whole sex symbol thing, it's hard for me to connect to that and the pressure of having to live up to that."
It should be no surprise, then, that Díaz showed up for his interview, at a West Hollywood café near his house, wearing black cords, Converse-style sneakers, and a black plaid shirt. Not quite the WeHo pretty boy uniform. And then there was his hair. "I did the Mohawk because we've shot the whole season already," Díaz explains, referring to the new ABC political drama Scandal, debuting April 5. He plays Huck, who, in the series' first episode, is a mysterious figure, unshaven, cloaked in a hoodie, lurking in the corners of the office run by Kerry Washington's Olivia Pope, a high-powered consultant and former White House publicist who spins her clients' way through political crises.
In later episodes Huck is revealed to be an ex-CIA agent, one of the show's fixers, and the firm's computer hacker. He hunts down information online and sometimes "goes out and takes care of it himself," Díaz says, cryptically. "He's sweet and tragic but really dangerous too. He's a nut."
"I always thought, if you don't want to work with me because I'm gay, then fuck you," he says. "I don't want to work with you either." But he got some pushback from his management at the time. "They were a little squirrelly about it. There was that, 'Well, don't be too gay.' "
Díaz was still living with his family when he came out publicly, yet he hadn't told them. "I mean, they knew I was playing a drag queen, but they didn't want to know too much about it." Díaz came out to his Cuban immigrant family when he was 27 and about to move out on his own. Now they're on board completely, and they know his boyfriend, Mike, whom Díaz has been with for seven years.
Ironically, it was gay audiences that gave him a hard time when he played another gay character, Angel, on Mercy. "I was trying to play him like a regular guy," by which Díaz means someone who "queens out" once in a while but is otherwise just like everyone else. But the network pushed him to be more flamboyant. "It's NBC," he says. "If a producer is telling me to gay it up, I've got to gay it up." Díaz continues, "I didn't necessarily agree with the way they were going, but at the same time, there are a lot of queeny guys and they're great. It's part of who we are, right? So I didn't get why people were upset, and at the same time, I kind of did."
It's at that time that he decided to pose nude for Pinups. He didn't think to tell his current management — whom Díaz is quick to point out are open-minded women who are very cool with his sexuality. "I don't know why I didn't say anything," he wonders now. "I guess I thought it wasn't going to be a big deal." Sure enough, when the photos came out, he got a call. "Guillermo, what the fuck are you doing?" he recalls being asked. "You could be fired for this!"
Díaz hadn't considered the morality clause, part of a standard television contract that he had signed with NBC. "I remember being really defensive and being like, 'You guys don't get it. What's the big deal? I'm just naked. I'm not hard. I'm not fucking.' "
Mercy was soon canceled, so any contractual crisis was averted. Now the photos are available with a few keystrokes of a Google search. "It's on Manhunt, and there's this thing that says, 'Would you fuck him or not?' " reveals Díaz. "And then it's all these people talking about me and how I'm fat or ugly. I mean, there's good stuff too, but the whole point of why I did the magazine is people acting that way."
He did it to prove a point — to others, and to himself — that he doesn't have to have a perfect body to be considered sexy, to be pinup-worthy, to be OK. "I'm not that hot guy, and I'm naked and you're still talking shit about how I look. You're proving me right. You know what I mean? It's kind of sad."
But he's resilient: "I'll just have to do another one. Just have to keep getting naked, until people get it."


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Hell to Pay: A Dogmatic Reward Strategy Can Seriously Damage Your Organisation's Financial Health-Which Is Why Management Accountants Should Get More Involved in Policy-Making. (Management)
Allen, David, Financial Management (UK)
The last weeks of 2002 were notable for the number of high-profile cases concerning the relationship between an organisation and its employees.
Most column inches were devoted to confrontations in the public sector. First came the hospital consultants' rejection of a deal that would have given them a salary increase of around 15 per cent, because in return they would have had to allow their work patterns to be governed by managers who, the consultants believe, are preoccupied with politically inspired but clinically inappropriate performance measures.
Then there was the firefighters' dispute, where the union insisted that its members were worth more money, even though there was a waiting list of people wanting jobs at the going rate. The government predictably resorted to "lump theory" in asserting that there was a fixed amount of money, so higher pay would inevitably mean fewer employees.
Part of the problem is that the public sector is widely seen as a monolith. Some parts of it are chronically short of recruits, but the idea of increasing pay in order to attract the people they need is shunned for fear that other areas would demand increases to maintain comparability, irrespective of market forces.
In the private sector, meanwhile, there were several cases where the directors of quoted companies were trying to gain shareholder approval for massive pay rises for at least some of their number. The arguments they invariably trotted out were that such packages--often running to millions of pounds--were essential if the individuals concerned were:
* to be motivated to do their best for the company;
* not to defect.
The good news is that institutional shareholders have woken up to this unjustifiable trend and have been intervening accordingly--but what a pity it's had to come to that. I cannot but wonder what impact those directors' obvious disdain for the concepts of commitment and loyalty has had on the morale of the middle managers who earn only 1 or 2 per cent of the sums demanded by their bosses, yet play crucial roles in the business. At their level, pay policies are still dominated by the concept of comparability across different jobs--again irrespective of market forces.
The common feature of these various confrontations is the underlying perception that what is being played is a zero-sum game--that is, if one side gains, the other side must lose. What's missing is the recognition that the motivation of employees is one of the most significant intangible assets an organisation can possess, and hence one of the main contributors to its financial health. The greater the motivation of employees, the more likely it is that customers will be delighted and an adequate return will be achieved. …


text:
Hate those whith white socks in bed.
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Watch this very hot housewife and MILF Lorena fuck a huge blackzilla sized dick. She takes him to her son's bedroom, where she sucks his huge cock before she gets on top and rides the manaconda. Loving every minute of it, she bends over and takes the monster black dick from behind. This is one mom who loves fucking a blackzilla!
All Comments (190)
Hate those whith white socks in bed.
nice cock, can i borrow?
I loled at the end : She speaks english ! -Only when necessary LOL but, that was hot.
Lorena Sanchez. One of the finest Latina's in porn!
Amy I bet you would like that big cock
hey amy u can borrow mine
I will borrow you mins amy!
was für ein praechtiger schwanz-
wish i was her lmao.
10:30 -- KEEP YOUR EYES CLOSED! That shit is not hot. lol
what is her name, she is gorgeous
gran bel cazzo
Socks nd trainers in bed ,nt natural..she is hot,she must be 29..loving it big mack,
i need that dick
Danny Glover?
he can only get the first four inches in her anyway lol.
amy you can take my fat cock anytime lets spread your tight pussy
daang thats a big dick , like huge. It'd probably hurt
mamma mia che pinga!!!
can someone fuck my pussy?
@ kay can i fuck your pussy?
All that cock and such a small load? Anyway: Hot girl, nice cock! I wish i had a cock like that!
that is bigger than my 11" :O
Wow,nice dick and som good sex there.wish could have such goodsex.horny!!!
shit dat dick is huge...
boia....popò di fava, dè....
thats funny me and my girl both laughed when she started speaking perfect english..
damn u people commenting are fucking horny,i love it
ill spread my tight pussy for anyone who will cum on mah big tittys
lovely dick mmmmmmmmmm
She is beautiful and knows how to take a big cock.
i want them both.
hey guys, you talk way too much. keep silent & enjoy the vid...
She sure didn't any of that big black dick,she took it all,I enjoyed the Pussy Farts at 7:53 from the wet pussy suction of his big dick.
i wonder if he will fuck my tight ass while i jerk my white cock
i love looking around the front of a black man pants.sorry i forget to lookup
that is the best fuck I have ever seen!!!!!!
i need a big black dick to fuck my juicy tight wet pussy! omg i'm so horny.
amy you can take my thick cock, you will love it !
Uuumm, that shit made me squrt. Im ready for a big black or white dick to slide in this pussy!!!
@ 1st let's get together and I will mount you all day.
lorena sanchez is a real trooper. she is fine as hell and she sure can take a lot of dick. and his dick is huge
id do anything for aa bbc....hope i get one soon
nice chin omlete
My latina girlfriend ran off with a black guy....now I know why :(
I want a woman like that pleaase !! Some girls like it on this forum?
black guys are so hot! his dick is funking HUGE!!!
damn tht cock is huge! i think the black cock im fucking right now is juz as big..i love! i came 3 times in 2 min the other nite! woo hoooo
man u dont fuck an gorgeus latina woman like that with socks on. what the fuck!!! she is awesome, im in love
'when necessary' LMFAO
i want that dick
Wow! Great fuck and a great cock for a great pussy. MIRA COMO EL NEGRITO ESE LE MANDA ESA PINGA HASTA LO ULTIMO, Y COMO ELLA SE LO GOZA. ESO SI ES CHICHAR.
wow i need a big cock in me now
fuck me fuck me fuck me! im so horny!
watz da guys name he cute nd he got a nice dick i want him...lol
i will fuck you with big fat cock jezebelle
you can knock a chick out with that dick
Big Dick- If you look ANYTHING like this guy, could you PLEASE cum fuck my hot wife? Trust me- you won't even notice me with the camera, or licking her pussy while you fuck her from behind.
@bryan.....im ready! You want me to fuck you wife??
why white girls prefer black cock ?
Thug87- Black and a big dick? YES! She NEEDS a good fucking. I need to see you fuck her and cum in her open mouth.
lmfao, . . lol she did that
@bryan Hi again.These sites are hot.This guy has a cock like JOHNATHON (horsepower).I just love to suck it.And horsepower shots more cum.
Now I know why my Mom cheated on my Dad when I found a film of her and a black dude.My eyes were glued on his big thick cock the whole film and Mom was enjoying it very much,as he came numerous times so did I as I gazed at his swollen member.He was so big and very hard the whole film.
yeah he has a huge dick but i dont believe if he has brain including she is too. sex is nice but it is not everything in life.
ozy- Sex IS everything in life....at least while you're jerking off. Lisa- Does he shoot in your mouth? Can you handle it all?
nice arse
@bryan ..My black stallion is better than this.He shoots like a volcano.He fills my mouth.
wats his name? he sexy nd i love his dick i want it lol
i can see her piss-hole :-D
Give me his name, pleeease!! D:
Yummy black cock..i squirted so much fingering myself.
@sexyLA u should get to know me i have cam and all.
@jrevLA..do you have a big black cock?
Lisa- WOW! I would LOVE to see your home videos....or better yet, you two in person.
girl yuo can handle a bigcock R
ha itz funny how sum1 is usin my username..anywho i love him i need him i want him lmao
I would love to have that cock in me!!! : )
@bryan...If I was your wife would let me have all the cock I wanted.I would luv to ride big cocks for you to see
@bryan...I wish you were my husband.I would let you watch me give blow jobs anytime. I would be so naughty for you. I would do lots of MILF porn
Lisa- Sounds like your Hubby is a great guy to let (and film) you sucking and fucking all the cock you desire.
ohha geeeil so ein dicken schwanz will ich auch haben in mein arsch
wow what a fuck
now where can i find someone to fuck me like that? damn.
i love to be fingered licked until i come and the fucked hard by a big black man and his cock, its fucking awesom i want that man
i dont think i can handle that big dick
love latina women
La verdad...nunca he opinado...pero con Lorena cualquiera se deslumbra...Su cuerpo y su Chochito es lo mas perfecto que he visto...
I'm Latina and I never been fucked by a big black dick, I always wanted to just can't find the good one to satisfy me
i wanna try a big black cock
she dont have 2 talk. im n memphis looking 4 a freak like that real talk
Awesome..wish i caught my girl with him..id love it..my cock is barely 3 inches..
El Mejor culo Latino Que e mirado
can u fuck me everyday? oh i wish i was her
fuck,fuck,fuck...i'm hotter than this girl and never met this kind of man...some are really lucky ,damn!
@mees i wana fuck you so hard now, eat your pussy, lick it, and drill your holes till you cum all over the place!!
These black guys are so sexy, how can i persuade my girl to fuck a black dude?
"only when necessary" looooooooool


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Festivals In Brief: Team Clermont, Camp Bestival, Shine a Light, Respect Jamaica Reggae
By Evan Minsker on July 3, 2012 at 8:32 p.m. EDT
WHAT: Team Clermont Summer Showcase & Prom
WHEN: July 26-27
WHERE: Athens, GA
WHO: Bear in Heaven, the Olivia Tremor Control, Dent May, Crooked Fingers, Pattern Is Movement, more
WHAT: Camp Bestival
WHEN: July 26-29
WHERE: Dorset, England
WHO: Happy Mondays, Hot Chip, Frankie Rose, Totally Enormous Extinct Dinosaurs, Little Dragon, Jimmy Cliff, Chic ft. Nile Rodgers, the 2 Bears, 2:54, more
WHAT: Shine a Light Music Festival
WHEN: July 21
WHERE: Wantagh, NY
WHO: The War on Drugs, Dean & Britta, more
WHAT: Jamaica 50 Festival
WHEN: July 25 - August 6
WHERE: London, England
WHO: Lee Scratch Perry, Damian Jr. Gong Marley with Stephen and Julian Marley, Toots & the Maytals, Jimmy Cliff, U-Roy, Junior Murvin, more
News in Brief: Chairlift/Rewards, Release the Sunbird, Fair Ohs, Teen Daze, Camp Bestival
By Larry Fitzmaurice on July 21, 2011 at 5:40 p.m. EDT
-- Brooklyn synth-pop outfit Chairlift will release a new single on Terrible Records August 16. Listen to the A-side "Amanaemonesia" at Forkcast. Former member Aaron Pfenning's project Rewards will release the "Equal Dreams" single July 25 on DFA. The title track features vocals from Solange Knowles. Listen to it here.
-- Rogue Wave's Zach Rogue has a new side outfit, Release the Sunbird; their debut LP, Come Back to Us, is out July 26 on Brushfire. Stream the whole album at NPR.
-- A few new releases from indie label Lefse: UK tropical-popsters Fair Ohs will put out their new LP Everything Is Dancing on July 26, while Canadian chillwave man Teen Daze's A Silent Planet is out on CD and cassette September 13 on sub-label Waaga. Head here to check out Fair Ohs' "Summer Lake", and head here to hear Teen Daze's "The Harvest".
-- Camp Bestival goes down July 28-31 in Dorset, England. Primal Scream, Blondie, Mark Ronson and the Business Intl., Laura Marling, ABC, Katy B, Ms. Dynamite, and others are among those scheduled to perform.
Festivals in Brief: Camp Bestival, Kendal Calling, Field Day, Wicker Park Fest
By Tom Breihan on July 15, 2010 at 3:15 p.m. EDT
WHAT: Camp Bestival
WHEN: July 30 - August 1
WHERE: Dorset, England
WHO: The Fall, Lee "Scratch" Perry, Joker, Joy Orbison, Friendly Fires, the Human League, George Clinton & Parliament Funkadelic, Madness, Marc Almond, Gold Panda, Field Music, Pete and the Pirates, Ragga Twins, Tony da Gatorra Vs. Gruff Rhys
WHAT: Kendal Calling
WHEN: July 30 - August 1
WHERE: Cumbria, England
WHO: Doves, Wild Beasts, the Futureheads, These New Puritans, British Sea Power, Badly Drawn Boy, First Aid Kit, Erol Alkan
WHAT: Field Day Festival
WHEN: July 31
WHERE: London, England
WHO: Phoenix, Caribou, Atlas Sound, No Age, the Fall, Mouse on Mars, These New Puritans, Memory Tapes, Joker and Nomad, Dam-Funk and Master Blaster, Pantha Du Prince, Matthew Herbert, Ramadanman, Simian Mobile Disco, the Golden Filter, Chilly Gonzalez, Moderat, Gold Panda, Mount Kimbie, Steve Mason, Gruff Rhys Vs. Tony Da Gatorra, Max Tundra, Silver Apples, Dam Mantle
WHAT: Wicker Park Fest
WHEN: July 31 - August 1
WHERE: Chicago, IL
WHO: Holy Fuck, Cap'n Jazz, Torche, Baroness, Plants and Animals, Yakuza Arkestra, the Gaslamp Killer, Scotland Yard Gospel Choir, the Hood Internet, Happy Birthday
Festivals in Brief: Camp Bisco, Camp Bestival, Indietracks, Splendour in the Grass
By Tom Breihan on June 1, 2009 at 3:50 p.m. EDT
A quick rundown of upcoming music festivals around the world:
What: Camp Bisco
When: July 16-18
Where: Mariaville, NY
Who: Nas and Damian Marley, Special Disco Version, Chromeo, Kid Cudi, the Orb, Dr. Dog, Flying Lotus, Holy Ghost
What: Camp Bestival
When: July 26-26
Where: Dorset, England
Who: PJ Harvey, Mercury Rev, Bon Iver, Phoenix, Chic, Aeroplane, Micachu, Roots Manuva, Tinchy Stryder, Florence and the Machine
What: Indietracks
When: July 24-26
Where: Derbyshire, England
Who: Camera Obscura, Emmy the Great, Au Revoir Simone, Lucky Soul, BMX Bandits, Rose Elinor Dougall, Tender Trap
What: Splendour in the Grass
When: July 25-26
Where: Byron Bay, Australia
Who: Bloc Party, the Flaming Lips, MGMT, Jane's Addiction, the Specials, Midnight Juggernauts, Friendly Fires, White Lies, the Gutter Twins
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text:
Email AddressVerified
Phone Number▒▒▒▒▒▒▒▒▒▒ 01
Reviewed91 Reviews
Offline IDPassport
- Work
- Property Manager & semi retired
- Languages
- English, Français
- Richard's Airbnb Symbol
Hey, I'm Richard!
We are a married couple, with 3 daughters, all of whom have left home. We have lived at Manor Farm since 1984 having bought it off Lissey's Dad. She lived here from 16 to 21 and we had our wedding reception here in 1973. All 3 daughters are married and we have 6 grandchildren. Our middle daughter who married in 2008 also had her reception here - real dejà-vous and she has Ella, Monty and Alfie. Our eldest, married on June 20th 2015 and they have a daughter, Mia and a son Charlie and the youngest just got married in April 213, and have a daughter born in March 2015.
We both retired early. Me from Estate Agency and Lissey from catering. We love having the grandchildren round, as all live relatively locally. We are keen gardeners and have to be with this property, although I do manage to fit in a few rounds of golf and we do like our holidays especially to our house in Brittany, France, which we have now finished completely renovating.
We also like being Airbnb guests, having had a 10 day trip around England and Scotland by train in October 2013 staying in some delightful Airbnb accommodation. We are went to my niece's wedding in San Francisco in April 2014 and then drove up to Vancouver and the whole 2+ weeks was in Airbnb.


text:
Sunridge Condos Vrmc
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
Travel Blogs from Beaver Creek
Day 6
Our earliest wake up yet: the alarm went off at 5:30, but
after going to bed at 10, we didn't have too much trouble.
We headed down to the Black Canyon of Gunnison National
Park. James was intent on actually having 3 meals after not being allowed to
eat anything substantial until dinner the day before (other versions of the
story would ...
Chocolate Frosties
... cab...he was worried about human trafficking. He told Jp they had just busted some drug smugglers in a cattle carrier. Apparently as the cattle carrier drove by they noticed that they could see the feet of the cattle...usually they can't. When they inspected the trailer they found that a compartment had been built under the cattle and it was full of drugs! Back around 8pm. Jp and I got chocolate frosties from Wendy's and watched the lightening. So ...
Back in Breck!
... a powerful engine, and awesome storage. However we have run into some serious issues. On day one the refrigerator door fell off and crushed Kristi's foot. Hours later the freezer door fell off in my hands. I spent hours patching it all back together only to have the whole thing quit completely while driving to Breckenridge. After hours of consulting with my friend Mr. Google, I was told that I should remove it and turn it upside down for 12 ...
... and went to the other Gondala and came up to the Adventure Ridge) hiked to Adventure Ridge (it was a mile). When we got to the top we were going to go on "the big ropes corse" but it was too expensive. So we settled on trampoline bungee jumping instead :) First we ate lunch then we went and did "bungee jumping." Edie and Ben both did back flips ;) and Tommy did NOT want to get off ;( he threw a HUGE meltdown :| When we got him to calm down we took a family photo ...
Aspen to Beaver Creek, Colorado
... on a daily basis!
Arrived in Beaver Creek and what an amazingly beautiful place this is. Reminds us of the village at Whistler with their trees decorated with lights, snow on the ground and this amazing mountain dominating the scenery. The hotel is right on the slopes so is ski in, ski out. Our room is lovely with a great view of the slopes. Can't wait to try them out tomorrow. Not sure if my knees are looking forward to skiing as much as I ...
Other places to stay in Beaver Creek
Christie Lodge47 E. Beaver Creek Blvd., Avon | 3 star condofrom $98
- Great Value, Great Fun
- Clean and Cozy
- Not worth the money
Borders Lodge1120 Village Road, Beaver Creek | 3 star condofrom $153
Meadows Townhomes Of Beaver CreekMeadows Lane., Beaver Creek | 3 star condofrom $363
St. James Place210 Offerson Road, Beaver Creek | 4 star condofrom $364
Townsend Place at Beaver Creek1270 Village Road, Beaver Creek | 3 star condofrom $199
Falcon Point Resort175 Lake Street, Avon | 3 star condofrom $89
Highlands Lodge Beaver Creek By East West ResortsSteglitz-Zehlendorf, Beaver Creek | 4 star condofrom $15
Elkhorn Lodge51 Offerson Road, Beaver Creek | 3 star condofrom $278
Poste Montane At Beaver Creek76 Avondale Lane, Beaver Creek | 4 star condofrom $150
Ridgepoint Townhomes at Beaver Creek85 Willis Place, Beaver Creek | 4 star condofrom $255
Oxford Court at Beaver Creek31 Avondale Ln, Beaver Creek | 3 star condofrom $347
Highlands Slopeside Beaver Creek By East West Resorts96 Highlands Lane, Beaver Creek | Condofrom $352
Park Plaza at Beaver Creek46 Avondale Lane, Beaver Creek | 4 star condofrom $428
East West Resorts of Beaver Creek15 Highlands Lane, Beaver Creek | Condofrom $200
Snow Cloud Lodge38320 Hwy 6, Beaver Creek | Condofrom $403
The Residences at Park Hyatt Beaver Creek136 East Thomas Place, Beaver Creek | Condofrom $169
Creekside at Beaver Creek1156 Village Road, Beaver Creek | 4 star condofrom $420
SaddleRidge at Beaver Creek Resort44 Meadows Lane, Beaver Creek | Condofrom $295
Highlands Westview Beaver Creek By East West Resorts32 Highlands Lane, Beaver Creek | Condofrom $445
Buckcreek Condominiums520 W Beaver Creek Blvd., Beaver Creek | Condofrom $130
St. Michael's College81 St. Mary Street, Toronto | Hostelfrom $250
Sunriver Condominiums39377 US Highway 6, Beaver Creek | Condofrom $139


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Walkers, tournament take up battle against breast cancer
Sixty miles on foot may sound like an incredible journey, but for Kim Pettigrew it is just a small step to ending a terrible disease.
Pettigrew, who serves as the Food and Beverage Director at Tunica National Golf and Tennis Center, has committed to participate in the Susan G. Komen 3 day for the Cure in San Diego, California in November.
"Walking 60 miles is a bold statement that we hope will encourage others to support us in our efforts to help find a cure for a this disease that is so close to our hearts and affects the lives of so many," Pettigrew said.
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