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The first time we made this dish, we followed the recipe pretty much to the letter. The next time, I substituted boneless pork chops for the tenderloin, searing them first in a cast iron skillet, then finishing them in the oven. I also thought the puree needed twice the amount of ginger. Served with a potato and apple galette with sage, it was a perfect winter meal.flag if inappropriate
This recipe was delicious and very easy. I loved the coriander and puts lots of fresh ground pepper. I have made it twice in the last two weeks, and everyone who has tasted in raved about it. I, too, made the jasmine rice timbales as a side dish.flag if inappropriate
My son has made this dish several times for the family and it is now his signature meal. I don't like cooked carrots but tasted the sauce to be polite and it was excellent! Also had the jasmine rice timbale as suggested and thought it was perfect. Really a good meal. Different and delicious!flag if inappropriate
I thought it was very good i think the sauce needs work and i would make this recipe againflag if inappropriate
The pork was nice, not spectacular, but oh my gawd, the carrot puree!!! That is to die for! I was a little leery of the carrot part, thought that it would be too much like baby food, but no no no!!! It is the best!flag if inappropriate
I made this on Mother's Day for my mother, best friend, and her mother. The carrot ginger sauce was incredible. I had to finish the tenderloin in the oven, but it came out perfectly. The timbales were very tasty as well, and the sesame oil brought it to the next level. I will definitely make this for a dinner party.flag if inappropriate
I have made this for guests several times, each with rave reviews. We love the coriander! I think the carrot ginger sauce is labor intensive, but well worth the effort!flag if inappropriate
I found the coriander alone did not give the meat enough flavor. The presentation was beautiful though and the whole meal was a snap, so I will try it again adding a little sea salt and pepper to the coating.flag if inappropriate
The carrot/ginger sauce was tasty, but we did not like it as a meat sauce. Since I am frugal (cheap) I used up the sauce by incorporating into a packaged yellow cake mix. I now get requests for my carrot cake with ginger and walnuts.flag if inappropriate
Although the pork was very tender cooked this way, the corriander was too overpowering. Will try a different recipe next time for pork tenderloin.flag if inappropriate

subset: commoncrawl


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Robin Neifield | December 30, 2009 | Comments
Like a financial portfolio, an online marketing strategy must be diversified and include some risk.
If you play e-marketing to win, you're playing a portfolio of tactics for long-term gain. If you have sufficient budget, there's simply no other tactic that will give you the same results over time as a coordinated, multipronged effort. Much like a solid financial portfolio, your online strategy needs to be diversified, respond to market conditions, and have a goal and timeframe in mind to make any sense at all.
Some financial investors choose to simply float with the market in a broad index fund, expecting and finding their results will mirror those of the market. Similarly, some investors in online marketing may simply repeat the same Google search marketing campaign or broad display campaign without taking advantage of new opportunities or testing new approaches. They believe they're creating a more certain future, but what are they giving up in exchange for that perceived stability?
As with a financial portfolio, you have to be willing to accept some level of intelligent risk with your online strategy. Not every trial will result in a win, but it will result in knowledge that can be applied to an ongoing effort to balance and optimize results.
Robin is off today. This column was originally published Sept. 9, 2009 on ClickZ.
Robin is the CEO and cofounder of NetPlus Marketing Inc., a top 50 interactive agency established in 1996 to focus exclusively on online marketing and advertising best practices. Robin brings innovative strategy and a depth and breadth of marketing experience to the agency's practice and management. As one of the industry's pioneers, she is a driving force behind NetPlus Marketing's ongoing success with a diverse and discerning client base that considers online results critical to their business success.
Robin is a frequent speaker at national industry events, including ClickZ, internet.com, OMMA, Ad:Tech, SES, Online Marketing Summit, and Thunder Lizard conferences and is a sought-after resource for industry and business publications for her insight and advice on such topics as digital strategy, social media marketing, and behavioral targeting.
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Take the oldest post and make it the newest post if there has not been a new post in 24 hours, thereby changing the order on home page and other lists


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Thursday, May 31, 2012
23 comments
Here's one from the Department of Redundancy Department.
... Read more
Wednesday, May 30, 2012
21 comments
It seems the Girl Scouts are getting more aggressive this year....
Note: This may be an 'intentional' mistake since the word "Aggressive" is spelled wrong. Either way... Read more
Tuesday, May 29, 2012
18 comments
This one simply makes me laugh...
... Read more
Monday, May 28, 2012
13 comments
I decided to post the pictures and recipe on Blogspot. It was easier for me to edit things that way.
Here's the link and I hope you enjoy it.
http://amusingwigi.blogspot.com/# ... Read more
Monday, May 28, 2012
20 comments
With the economy being what it is, some people have to take a second job. Others want to, but don't know where to get started. This book may provide the help you so desperately need.
Read more
Sunday, May 27, 2012
19 comments
And Captain Obvious strikes again!
By the way, I did take a lot of pictures yesterday of my burrito making. It takes a while to edit them before posting the pictures ... Read more
Saturday, May 26, 2012
24 comments
... Read more
Saturday, May 26, 2012
10 comments
Friday, May 25, 2012
15 comments
Someone's falling, but it won't be in love....
... Read more
Thursday, May 24, 2012
20 comments
Take THAT food critic!
... Read more
Wednesday, May 23, 2012
15 comments
Fair warning and an advertising opportunity!
... Read more
Tuesday, May 22, 2012
11 comments
I just had to share with you what I fixed for breakfast this past Sunday. My in-laws are currently visiting us for a while and I always try to make some nice meals for them. The link to the recipe is below the picture.
Read more
Tuesday, May 22, 2012
13 comments
I'm thinking that Tom's school isn't so superior after all....
... Read more
Monday, May 21, 2012
22 comments
Cat Beard
... Read more
Sunday, May 20, 2012
18 comments
A store with a sense of humor.
... Read more


text: Warning: Only variables should be assigned by reference in ..../album.php on line 1871 Recently Updated Albums Register Help Remember Me? Forum Menu Today's Posts New Posts Mark Forums Read Mobile Connect Members Gallery Menu Chat Settings My Profile Messages Advanced Search Albums Recently Updated Albums If this is your first visit, be sure to check out the FAQ by clicking the link above. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below. Recently Updated Albums Recently Updated Albums Template Caylalily, 10-05-2015, 04:03 PM Photos: 1 Contact Us goDigitalScrapbooking Archive Web Hosting Top All times are GMT -8. The time now is 09:34 PM. Powered by vBulletin® Version 4.2.2 Copyright © 2015 vBulletin Solutions, Inc. All rights reserved.


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We all know that Lala is known for her "hook up skills" and on this episode of "Lala's Full Court Life", she's put to the test and is challenged with the task of helping her cousin, Dice, find a Valentine. Of course, to make things interesting, Po and Lala make a bet that they can find Dice the perfect girl for Valentines Day, and the bet is on. If Po loses, she has to go streaking through Times Square (let's hope she doesn't get arrested) and is La loses she has to hold two live mice in her bare hands (gross). La tells Dice that the best way for her to get over her old love is to start dating and meet new people. Lala devises a plan to have a mixer in NYC and screen different girls before introducing them to her cousin. She, Po and Charlamange are the "judges" and bring each of the girls in one by one to grill them. Things go a little south when one of the prospective candidates shows her panties on camera… NEXT!!
Countries With The Most Plastic Surgery Per Capita (PHOTOS)
Since the mixer was a complete and ultimate FAIL, Lala tries a dating site. After making Dice the perfect online dating profile, Lala sorts through the list of prospects and finds who she thinks is the perfect girl for Dice and sets the date up. Dice doesn't seem too thrilled by Lala's choice, and says that the date is going just "alright".
After hearing that the girl Lala chose may not be the right one, she's worried about losing the bet and she plans to sabotage the date Po has set up for Dice. Part of La's plan is to talk to Dice's date before their evening begins and tells her lies saying that Dice likes women who drink and women who are aggressive. Lala's plan to sabotage the date fails, and the date actually goes really well. Looks like Po won this one!
Back at home, Dice declares Po as the winner of the bet, and now Lala must hold two live mice in her bare hands, GROSS! Dice brings in the box of two lives mice, and La freaks out and refuses to hold them. "I'll admit, I'm a failure", Lala says, but we don't blame you for not holding the mice!
As part of her sabotage, La spots Po's date on her way in to meet Dice. La calls her over and tells her lies: She tells her Dice likes aggressive women and loves a woman who drinks. But despite her best efforts, it doesn't work – the date goes well!
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Buy houses in Pine Street, Bradford BD1 - 2 bedrooms
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Hillside Terrace, Bakerend, Bradford BD3Terraced house for sale - 2 bedrooms
Keymove Sales are pleased to offer this 2 bedroom rear back to back property located in this sought after location in barkerend. The home on offer is in need of some renovation and would be ideal for a first time buyer or family alike. Comprises of: ... More details
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Marketed by Keymove Sales & Lettings, BD13. Call 01274 506716


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The month of May is upon us and once again there is a ton of great live music for us to sink our teeth into. But one show in particular stands out as an extra-special treat. On May 11, Creedence Clearwater Revisited is coming to the Seminole Hard Rock in Hollywood, Florida for a night of classic tunes and an old-fashioned good time.
Revisited is a project put together by founding Creedence Clearwater Revival members Stu Cook and Doug "Cosmo" Clifford to continue a musical tradition they set in motion some four decades ago.
"It's an honor to be able to represent this music," said Cook. "It's an honor, a labor of love and it's fun."
For 17 years, Revisited has toured relentlessly bringing the Creedence classics to fans old and new across the globe. Having been around over four times as long as Revival, Revisited is more travelled, more rehearsed and consistently delivers performances true to the original songs, with an expanded lineup to recreate the full, earthy sound of the Revival records.
Despite the absence of Revival frontman, John Fogerty, Revisited has established itself as Revival's ambassadors to the present age. "Our reputation is built on being able to deliver without [Fogerty]," said Cook. "The music has always been separate from the personalities. It's all about the music."
Don't miss out on the opportunity to catch Creedence the way they were meant to be experienced. Skeptics are welcomed—Revisited will surely make them believers by the time the last chord rings.
Tickets are available for $45. The show starts at 8 p.m. on Wednesday, May 11.
[1] http://www.miami.com/music-miami
[2] http://www.miami.com/ultra-music-festival-fans-can-expect-cheaper-ticket-prices-2016-article
[3] http://www.miami.com/nightlife/ultra-music-festival
[4] http://www.miami.com/nick-jonas-heads-miami-perform-sexy-rampb-hits-article
[5] http://www.miami.com/lazy-sunday-takes-new-meaning-fool039s-gold-day-music-event-article
[6] http://www.miami.com/dweezil-zappa-honors-his-father039s-legacy-south-florida-concert-article
[7] http://www.miami.com/rick-springfield-brings-tour-south-florida-article
[8] http://www.miami.com/amtrac-takes-over-basement-friday-august-28-article
[9] http://www.miami.com/mowgli-s-play-two-free-pop-sets-miami-beach-monday-article
[10] http://www.miami.com/life-color-early-bird-tickets-are-now-sale-article
[11] http://www.miami.com/ariana-grande039s-summer-tour-miami-south-florida-concert-review-article
[12] http://www.miami.com/do-not-sit-furniture-kicks-independence-day-weekend-nora-en-pure-article
[13] http://www.miami.com/willy-chirino-and-carlos-oliva-deliver-miami-sound-saturday-arsht-center-article
[14] http://www.miami.com/david-crosby-performs-miami-article
[15] http://www.miami.com/ec-twins-take-over-e11even-cam-con039s-official-after-party-article


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A federal appeals court in New York ordered the government to rewrite its rules regulating the discharge of ballast water by ships, in a victory for environmental
The U.S. Department of Transportation's Maritime Administration (MARAD) announced it will provide more than $1 million to support the development of two new emission-reducing maritime solutions.
Press release - Becker Marine Systems and KOTUG signed a Memorandum of Understanding to launch a LNG Hybrid Barge in the Port of Rotterdam with effect from June 2017.
Under new maritime laws all vessels and boats using Fiji waters have to abide by the rules and regulations under the Marine Transport Decree, reports FBC
Turkey launched the 140-meter amphibious ship "Bayraktar," the first of two vessels that are part of a domestic Landing Ship, Tank (LST) project, reports Local media.
The Coast Guard urges the public Thursday to use extreme caution and to prepare for the onset of heavy weather, extreme sea conditions, storm surge and high


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Interview with Alexey Leonov, the First Man to Walk in Outer Space
On 18 March 1965, FAI celebrates the 50th anniversary of the first space-walk. Russian cosmonaut Alexey Leonov achieved this feat during the Voshkod 2 mission. He stayed out in space for 12 min 9 sec, a performance that the FAI recognised as a world record in the "Extravehicular duration in space". Born on 30 May 1934, he still lives in Russia.
18 March 1965: Leonov Successfully Made the First Spacewalk
Today is a special day in the history of space exploration. It is the day, 50 years ago, that Russian cosmonaut Alexey Leonov became the first person to walk in space.


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How do your pets react if you sing at or in front of them?
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It's the face. Most are docile love bugs content to just lounge around and amaze people with their stunning beauty. ;)
Yeah u know...with this breed..they always seem far from amused
Ahhhh yes. Just one of the many reasons why if it is not a Persian, it is just a cat. ;)


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Country Inns By Carlson Wildwood Crest properties are provided below. Search for cheap and discount Country Inns By Carlson hotel rooms in Wildwood Crest, NJ for your personal or business trip. We list the best Country Inns By Carlson Wildwood Crest hotels & motels so you can review the Wildwood Crest Country Inns By Carlson hotel list below to find the perfect place.
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With a stay at Country Inn & Suites By Carlson, Absecon, NJ in Galloway, you'll be convenient to FAA William J. Hughes Technical Center and AtlantiCare Regional Medical Center.


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LAGUNA HILLS – The City Council voted unanimously Tuesday to extend the hours of the Chuck E. Cheese on Moulton Parkway by 16 hours per week.
The entertainment center, located in the Moulton La Paz shopping center, will now maintain hours from 9 a.m. to 10 p.m. Sunday through Thursday; and 9 a.m. to 11 p.m. on Friday and Saturday.
Previously, the center was open 10 a.m. to 9 p.m. daily.
"I hope that the closing of the restaurant is closer to 11 p.m. than 11:30 p.m.," said Mayor Randal Bressette, who said he was concerned about patrons loitering after closing hours, which might disrupt residents.
Extending operating hours was requested by CEC Entertainment, which owns Chuck E. Cheese, and recently took over this location in March from a previous franchise owner.
Alice Winters, director of licensing for CEC, said the extra hours would make the Laguna Hills location consistent with the other 77 Chuck E. Cheese locations in California.
Councilwoman Melody Carruth asked if the later hours would change the demographic and perhaps appeal to teenagers.
"Actually, you know, a teenager wouldn't be caught dead in a Chuck E. Cheese," Winters said.
Winters said the hours changing would give patrons, namely parents, more flexibility in planning parties.
Want a beer with your pizza?
Winters also said the location intended return to the council to apply for license to serve alcohol—namely beer and wine. She said all but three Chuck E. Cheese locations in California have licenses to serve alcohol.
Bressette said he had trouble reconciling serving alcohol at a restaurant like Chuck E. Cheese that catered to kids.
"We have to please mom and dad too," Winters said.
Contact the writer: 949-837-5200 or email@example.com


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just turned 18 and your baby just turned 6 months, you probably shouldnt get pregnant again for a long time which would mean being very consistent about using birth control when you have sexual intercourse... Yeah. If only the girl in my Teen Parents group knew...
DYN If you...
Posted 04/19/2011
Ireland Andi Ellie 7/10/10 & Batman due 8/14/13
"Take your pussy asses to CHURCH" - WorthlessNoName
Comments (3)
Last edited 11/02/2011
Proud parents of two wild boys
♥Michael Reed♥ & ♥Ronald Lee♥
FutureGryffindor · Original Poster
Posted 12/27/2012
Indeed, I am! The only difference between this girl and I is that: my child is two, my husband has a wonderful and stable job, we are moving out of our apartment and into a house in March and I am almost done with school to become a medical coder at 17/an hour. Meanwhile, she did wind up pregnant again with another mans baby and works at Wendys. When not found at work, you can find her sneaking into the local mexican resturants bar before having her mother pick her up to take her home. And yes, they do still live together.
Ireland Andi Ellie 7/10/10 & Batman due 8/14/13


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Girls Disney Cinderella Live Action Children's Costume (ref: 77833)
- Your Price:
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- Don't let anyone stop your little one from stepping into the shoes of Cinderella with this stunning costume.
- Includes a blue mid length dress with strap sleeves and a beautiful glittered butterfly bodice.
- This magical dress also features a delicate mesh shoulder trim with attached 3D butterflies.
- Finishing off the outfit is a butterfly comb which can used when getting ready or as a headpiece.
- Available in - Small: Age 3-4 years / Medium: Age 5-6 years / Large: Age 7-8 years


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So sorry, but only 4 items are allowed for comparison. I blame the gnomes and so should you.
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About Cycling Shorts:
The office is kind of cold today and none of my multiple layers are remedying this problem for me. Now while an inconvenience though, I do have to say that cold weather is so much better than hot weather. You're probably thinking I'm crazy or could be cool and agree with me, but more than likely you think I'm insane and want me to spend the rest of my life in Antarctica. My rationale is this: you can escape the cold weather, just add some layers a nice blanket, hot coffee and you're good to go. In contrast, you can't easily escape the heat. The closer you are to escaping the heat, the closer you are to getting arrested for public nudity. That is my opinion and I am sticking to it. Other things you can't easily escape: what The Rock is cooking.
Now as we are on the topic of wanting to stay cool, some clothing perfect for keeping you cool while bicycling are cycling shorts. Cycling shorts are specialized shorts, most made from breathable, moisture wicking fabric, to keep you cool and sweat-free while riding your bike. Moosejaw carries both form-fitting and loose-fitting type of shorts for bicycling for you, whichever suits your needs while riding. If you're into more long-distance riding, I recommend getting from padded cycling shorts, though. Padded cycling shorts keep your butt nice and comfortable while you complete your local Tour de France on your bike, so you should totally get them. Also, added bonus is that they'll make your butt look super nice, and who doesn't want a nice butt.
Anyway, if you want some great shorts for bicycling, either loose-fitted, form-fitted or padded, Moosejaw has got you covered. We carry all the brands and styles you love to ensure a great experience when trying to find the cycling short that's right for you and your bike ride. Maybe after picking your cycling shorts and taking that first bike ride, you can take them out to dinner, because now starts the beginning of beautiful bicycling relationship. Awe!
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Hotels in Spain
The romantic ambience at this hotel features soft lighting, lots of black and grays, and very modern rooms with views onto one of the city's main arteries. The restaurant and the bar are splendid as well, and you're a two minute walk from Las Ramblas and Plaça Catalunya.
My favorite hotel on this list, the Neri offers fantastic rooms, excellent room service, and one of the most beautiful environments in the city—it's right in the middle of El Gotic, Barcelona's medieval quarter.
The main reason for including this hotel on this list is the building itself. Occupying a former 1911 palace and designed by the modernist architecture Lluis Domenech i Montaner, Casa Fuster is Woody Allen's hotel of choice when he comes to Barcelona.
This is a great four-star hotel in a nice location in the center of the city. I personally appreciate the décor, which is both very modern and very homey); I also like the layout of the guest rooms, the lobby design, and the bar, but above all I love the terrace.
The Spain-based chain of Room Mate hotels is famous around Europe for their combination of good design and affordable pricing. This is the first establishment the brand opened in Barcelona: it's a boutique hotel with a high level of personal service.
This is the hotel that started the boutique hotel movement in Barcelona, in my opinion; Camper is a famous Spanish brand of shoes, and the owners decided to extend their eco-friendly philosophy to the operation of a hotel.
This is my top recommendation on this list. The hotel is beautiful; every detail has been thought out carefully, the breakfast is wonderful and the service is unbeatable.
One of my favorite boutique hotels in Barcelona, this place makes you feel like family. Nice rooms, an excellent location, and above all, a truly personal relationship with guests. It's a small place (11 rooms and suites) where you can choose from a simple room to a huge apartment.
Probably the best hotel in Barcelona when it comes to value, the Banys Orientals combines nice design and awesome rooms with an incredible price and a location (El Born, right near the beautiful Barcelona Cathedral) that is pretty unbeatable.
At this four-star boutique hotel, you can enjoy large rooms in with minimalist decor, a chic rooftop terrace with umbrella-shaded tables, and a ground-floor restaurant serving free "mini-brunch" and tea to guests (a bigger breakfast buffet is available for $15).
One of the best budget chains in Spain, Petit Palace has four great outposts in Barcelona. At all of them, the beds are comfy, most of the rooms have hydro-massage showers, and the staff is more than helpful.
This is a very stylish hotel, which offers both a great breakfast and splendid rooms just a few minutes' walk from Passeig de Gràcia in the city center.
This great, modern Madrid-based chain has hotels all over Europe that are great for budget travelers; their properties all have nice design (especially the bathrooms), good beds, and friendly staffers. There are two hotels in Barcelona—Emma and Pau—and both are brand new, with good locations.
Another of the city's classic luxury hotels (and a favorite of traveling businessmen), the Majestic is located right in the middle of Passeig de Gràcia (the largest shopping area in Barcelona), and houses an opulent spa.
This quiet, cozy hotel in the historic heart of the city is a good idea if you want to enjoy an intimate Barcelona stay without sacrificing high-class service. The thing I love most about this place is its garden: big and peaceful.


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Faculty/Research/Full Time/Positions
Current Open Positions:
- Department Head Position is Available, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX
- University of Minnesota, College of Veterinary Medicine Dairy Production Medicine Faculty Position Available
- Department Head Position Available, North Dakota State University Veterinary and Microbiological Sciences, Fargo, ND
- Veterinary Parasitologist job available at the University of Wyoming, Laramie, WY
Department Head Position is Available, Veterinary Pathobiology, Texas A&M University
Department of Veterinary Pathobiology
College of Veterinary Medicine
Texas A&M College of Veterinary Medicine & Biomedical Sciences
College Station, TX
(Announcement posted June 15, 2015)
The Texas A&M College of Veterinary Medicine & Biomedical Sciences invites applications/nominations for the position of Department Head of Veterinary Pathobiology.
The Department of Veterinary Pathobiology (VTPB) embraces the Texas A&M University's dual missions as a leading Land Grant University and AAU Public Research University and upholds a tradition of excellence in research, education and outreach. We are the home department for the Schubot Exotic Bird Health Center, the Cardiovascular Pathology Laboratory, and three NIH training grants (T32 and R25 for residents and graduate students; T35 for veterinary students). We have extensive interactions with Texas A&M AgriLife Research, TVMDL, and the Texas A&M Health Science Center. The VTPB faculty includes 3 Distinguished Professors (the highest faculty title in the university) and one member of the National Academy of Sciences.
In addition, a new Veterinary & Biomedical Education Complex will open in spring 2016 which will house state-of-the-art learning environments to not only meet current teaching needs, but be flexible enough to meet our educational needs in the next 50 years. This is an exciting time to join the CVM at Texas A&M University.
We seek an individual who will lead our faculty members, promote their career development, and assist them in achieving their professional goals. Accordingly, we seek an individual with strong leadership skills, internationally recognized research, and a commitment to education. Experience in academic or corporate administration is desirable. A commitment to diversity and fostering a culture of inclusiveness is expected.
The successful candidate must have a PhD and/or DVM (or equivalent) degree, qualify for appointment as a tenured full professor, and have a record of teaching excellence and extramurally-funded research.
Texas A&M University offers an extensive benefits package and is an equal opportunity and affirmative action employer. Minorities and women are strongly encouraged to apply.
University of Minnesota, College of Veterinary Medicine Dairy Production Medicine Faculty Position Available
University of Minnesota
College of Veterinary Medicine
Veterinary Population Medicine Department
St. Paul, MN
(Announcement posted April 7, 2015)
Position (Req: 197842)
The University of Minnesota, College of Veterinary Medicine, Veterinary Population Medicine Department wishes to fill a full–time tenure–track Assistant, Associate or Full Professor faculty position in Dairy Production Medicine. The final rank and terms of appointment will depend on the qualifications and experience of the selected candidate consistent with collegiate and University policies.
Requirements and Preferences:
Candidate must have a DVM, VMD, or equivalent foreign degree. An advanced research degree (e.g. MS or PhD) or an equivalent degree from a foreign institution is also required. The candidate must have a keen interest in teaching DVM students and a commitment to continuing education programming. Field practice experience in dairy veterinary medicine, either in private practice or in an academic ambulatory practice, is required. The candidate must also have a strong interest in and the potential to develop a funded research and graduate training program in a discipline relating to dairy production medicine. Research and teaching area of emphasis must include bovine theriogenology, but may also include other bovine–related focus areas including, but not limited to, infectious disease, metabolic disease, pharmacology, udder health, welfare, biosecurity, or food safety and security. The candidate must have excellent communication and presentation skills and the potential for synergy with existing dairy faculty and the College and Department's strategic goals and plans. Candidate must be eligible for licensure in veterinary medicine in the state of Minnesota (http://www.vetmed.state.mn.us/) or be board certified in a recognized specialty college.
The position will require active participation in both didactic and clinical teaching of bovine theriogenology as well as other discipline related material in the DVM curriculum. The faculty member will be expected to develop a program of independent research in a discipline relating to dairy production medicine. The faculty member will also be expected to contribute to a team effort in the dairy program and to participate in graduate and residency education programs and continuing education. The person in this position will have the opportunity to play a significant role in the development and implementation of programs at the college's National Dairy Education Center, an affiliation site within a large commercial dairy. Other opportunities include collaboration with members of the College of Food, Agricultural and Natural Resources Sciences, and Academic Health Center.
Commensurate with experience and qualifications. The University offers an excellent benefits package. For example, the University pays 100% of the premium for Faculty Basic Life Insurance as well as 100% of the premium for Faculty Group Income Disability Insurance. Faculty contributes 5.5% of their annual salary and the University contributes 10% toward the Faculty Retirement Plan. There are also two Optional Retirement Plans available. For more benefits information see: http://www1.umn.edu/ohr/benefits/
Begin: Expected start date is negotiable; position is available immediately.
Application Deadline:
Applications will be accepted until a suitable candidate is recruited. The search committee will begin reviewing completed applications after May 15, 2015. Candidates who are potentially interested in the position are encouraged to call and speak with the search chair Dr. Sandra Godden (office: 612-625-8177; email: firstname.lastname@example.com) to discuss the University of Minnesota's program and new opportunities available at Minnesota.
Interested candidates must apply online at: http://z.umn.edu/dairyfaculty and include a curriculum vitae, letter of application, and the names and contact information of three references.
The University of Minnesota is an equal opportunity educator and employer.
About the University of Minnesota College of Veterinary Medicine Dairy Program:
The College of Veterinary Medicine is located on the smaller St. Paul campus which is a 10 minute bus ride from the Minneapolis campus. Classes at the College of Veterinary Medicine have 100 students per year with approximately 25% of students tracking in large and mixed animal medicine. The U of M ranks near the top of Universities in terms of students interested in large animal medicine/surgery. The University of Minnesota also provides teaching support through the Center for Teaching and Learning. The College hosts a strong group of researchers and educators in dairy veterinary medicine and dairy production medicine. There are faculty working on dairy and bovine medical and production issues from the genomic level to overall herd management, health promotion, and public health. The College is proud to be the home of the nation's only USDA National Center of Excellence in Dairy Education. This teaching and research facility is built into a large dairy in southern Minnesota that serves as the transition facility for over 10,000 calvings per year.
About the Minnesota Dairy Industry:
The Minnesota dairy industry is a vibrant mix of herd types ranging from small stanchion herds to very large consortia dairies with over 10,000 cows. The state ranks 8th among dairy states, with 460,000 cows on 3,600 dairy farms averaging 19,800 pounds of milk per cow. Minnesota's dairy industry is a key component of the state's overall economy and is currently aiming for 2% annual growth in total milk production. Minnesota's dairy industry includes both dairy production and processing, with a combined total direct output value of $5.6 billion (2008). The processing sector in the state is robust and growing.
About Living in Minnesota:
The Twin Cities metropolitan area (St Paul/Minneapolis) is the 16th–largest metropolitan area in the country and ranks among the country's most desirable places to live, offering exceptional cultural, social, and recreational opportunities. The public school system in Minnesota is excellent and the University of Minnesota Day Care center is among the best in the nation. Livability.com recently ranked Minneapolis as the healthiest city in the U.S.
(http://livability.com/top-10/health/top-10-healthiest-cities/2015/minnesota/minneapolis). Minneapolis was also voted THE MOST FUN PLACE TO LIVE by Cranium. The Twin Cities host 4 major professional sports teams, are a cultural center for theater, opera, museums, great shopping and have an international airport providing a direct connection to most major cities. State parks are plentiful and hiking, skiing, swimming, boating and fishing are within minutes of most anywhere in the twin cities area. You can live in the country with only a 30 minute commute to the Veterinary College. Really it is not that cold and people love it here!
For more information, see these websites. www.exploreminnesota.com, www.minnesotaschools.com, http://www.ci.mpls.mn.us.
Department Head Position Available, NDSU Veterinary and Microbiological Sciences, Fargo ND
Department of Veterinary and Microbiological Sciences
North Dakota State University
Fargo, ND
(Announcement posted March 10, 2015)
The NDSU Department of Veterinary and Microbiological Sciences is currently seeking a senior colleague for the position of Department Head. Our faculty train undergraduate and graduate students in a broad range of topics in the areas of microbiology and immunology, including infectious diseases, microbial ecology, genetics and genomics. In addition, the department has well equipped laboratories and nationally recognized areas of research funded by NIH, NSF, and USDA. The Head will foster excellence in research, teaching, and service within the department. In collaboration with faculty, the Head will lead the continued development and articulation of the departmental vision. In addition, the Head will develop and maintain productive, collegial working relationships with the university, scientific communities, and the public, as well as agricultural constituencies. The Head will manage the department's human, financial, and physical resources, which will include conducting performance evaluations, preparing and submitting administrative reports, administering merit–based pay increases, and providing oversight of budgets and physical facilities. The Head will recruit and retain outstanding students, staff, and faculty; will promote an environment that fosters diversity, collegiality, and teamwork; and will actively seek resources for the support of departmental programs including leading advocacy efforts at the national and state levels. It is anticipated that the Head will contribute to academic, research and/or service programs as is commensurate with the Head's administrative responsibilities.
Minimum qualifications:
- Earned Ph.D. in life sciences from an accredited institution
- Distinguished academic credentials and eligibility for appointment as a tenured, full professor
- Evidence of successful and effective leadership experience
- Evidence of effective oral and written communications skills
- Evidence of ability to work effectively with diverse groups
- A commitment to shared governance with faculty, staff, students, and administrators
- Experience with budgets and professional staff
Preferred qualifications:
- Experience in recruiting, evaluating, and retaining high–quality, diverse faculty, staff, and students
- Knowledge of and experience in the land grant university system or a willingness to learn
- Evidence of an active, successful research program in life sciences
- Evidence of successful and effective teaching at the post–secondary level
- Evidence of leadership and team–building beyond departmental and disciplinary lines
- Evidence of academic or professional international experience
- Experience mentoring faculty
- Ability to advocate for the department within the university and to external stakeholders, government, and scientific groups
Application Procedure:
Review of applications will begin June 1, 2015 and will continue until a suitable candidate is identified. Applications are accepted online only at https://jobs.ndsu.edu/postings/6048. Create an account, and create and submit your application when prompted.
The application must include a: 1.) cover letter; 2.) curriculum vitae; 3.) statement articulating a vision for microbiology at a land grant university; and 4.) names and contact information (telephone numbers, postal address, email address) of five professional references.
Requests for information and/or written nominations may be sent to:
Dr. Frank Casey, Search Committee Chair
NDSU is an EEO/AA-M/F/Vet/Disability Employer
NDSU is an ADVANCE Institution and Carnegie Very High Research Activity Institution
Veterinary Parasitologist job available at the University of Wyoming
Department of Veterinary Sciences
University of Wyoming
Laramie, WY
(Announcement posted March 3, 2015)
The Department of Veterinary Sciences at the University of Wyoming seeks a full-time, tenure-track clinical Parasitologist at the Assistant Professor level. Minimum requirements: PhD in a relevant discipline and/or DVM plus a research Master's degree in a relevant discipline. Documented parasitology clinical diagnostic experience and demonstrable biomedical research ability are required. Demonstrated excellent interpersonal and communication skills, and ability to work with others in a collegial team atmosphere are required. Preferred qualifications: DVM with PhD in a relevant discipline; residency training plus certification in a laboratory diagnostic discipline by American College of Veterinary Microbiology (ACVM), American Association of Veterinary Parasitologists (AAVP) or equivalent professional certification. Demonstrated interest, aptitude, and capability for scholarly activity related to parasitic diseases of livestock, wildlife, and/or companion animals is highly desirable, as is teaching expertise at the undergraduate, professional and/or graduate level.
The candidate will function as a diagnostic veterinary parasitologist in a team with other animal disease experts within the Wyoming State Veterinary Laboratory (WSVL). Diagnostic duties include parasitological examinations on diverse species of animals to diagnose causes of disease. In addition, successful applicants will establish and/or maintain extramurally funded and/or collaborative research programs, teach at the undergraduate and graduate levels, and collaborate with a vibrant community of basic and clinical scientists within Veterinary Sciences and other degree programs. Position duties and anticipated percentage efforts are: professional diagnostic servic and extension in the WSVL (40%) including: supervision of daily operations, long–term planning, and development of a modern, service–oriented animal diagnostic parasitology laboratory; research or creative activity (30%), teaching (25%) and University service (5%).
The position offers excellent potential for collaboration and professional growth. Traditional parasitological methods will be employed as well as molecular diagnostics such as PCR and sequencing/genome analysis. There is a need for development of improved or novel approaches for diagnosis of important parasite pathogens in a wide number of animal species. The WSVL has a good working relationship with the Wyoming Department of Health, Wyoming Game and Fish Department, and other governmental agencies and non–governmental organizations.
The University of Wyoming, a land grant institution, is the only four–year university in the state. The University is located in rural southern Wyoming in the small city of Laramie, population approximately 30,000, close to excellent outdoor activities in the nearby Snowy and Laramie Ranges and near cultural and other amenities along the Front Range of Colorado. For more information department and the Laramie area, please visit: http://www.uwyo.edu/vetsci/ and http://visitlaramie.org/.
The University of Wyoming is an Equal Employment Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status or any other characteristic protected by law and University policy. Please see www.uwyo.edu/diversity/fairness.
We conduct background investigations for all final candidates being considered for employment. Offers of employment are contingent upon the completion of the background check.
Application Materials Required:
Review of applications will begin March 30, 2015, and will continue until a suitable candidate is identified. To be considered please send: 1) a cover letter outlining qualifications 2) curriculum vita,and 3) names and contact information for three professional references (electronic submission as PDF files preferred) to Dr. Ernest (Search Committee Chair) care of Ms. Marjorie Jaeger (email@example.com). Individuals with questions are encouraged to contact Dr. Ernest by email (firstname.lastname@example.com) or telephone [(307) 766-9925].


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Finish first with the DeSoto™ Forza Riviera Tri Short. A serious short for a serious athlete. Now with pockets!
size off
the quality of the material in the shorts is really good. the problem I have with it is my legs don't fit in that well the too tight and the pad is not as comfortable
Las cruces nm
Fit: Feels too small
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Baught these for my first Triathalon, one of those beginner TRI a TRI ones
I'm used to Bike shorts but had to do my first TRI swim. These were perfect, they were seamless in the water, they did not feel wet on my bike and I forgot they were there on my run. That's an A+ in my book .
Washingtonville NY
Fit: Feels true to size
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The founders of DeSoto are Emilio De Soto and Dan Neyenhuis. Emilio De Soto is a triathlete who is racing in his 27th consecutive season of triathlon competition. He is also fully immersed in his athletic lifestyle as a fitness trainer and coach. Dan Neyenhuis is an age-grouper triathlete who has been helicopter skiing for 20 years. Together, they created a company that designs cutting edge triathlon gear for triathletes, by triathletes.
DeSoto gear is designed to enhance performance in each leg of the race. The founders created the first mesh running cap, zippered tri tops, pocketed tri shorts, transition packs, tri suits, and tri shorts with discreet pads for cycling.
One of their other achievements was creating the DeSoto T1 triathlon wetsuit that is two pieces instead of one. The DeSoto T1 triathlon wetsuit was designed to make a better fit for triathletes, and each year, more DeSoto tri tops and DeSoto tri shorts are being added to the line. DeSoto is still the only company in the world that makes a two-piece triathlon wetsuit.


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Nick Jonas Confirms 'American Idol' Judging Talks
The rumors are true! Nick Jonas confirmed that he's in negotiations to be the next 'American Idol' judge.
The rumors are true! Nick Jonas confirmed that he's in negotiations to be the next 'American Idol' judge.
Snoop Dogg, or rather Snoop Lion, is jumping on the 'American Idol' bandwagon, adding himself to the list of possible new judges for the hit FOX series … kind of.
Flamboyant singer Steven Tyler announced his exit from the judging panel of 'American Idol' a few weeks ago, and now the Aerosmith frontman has gone on the record (so to speak) about what working on the show was really like.
'American Idol' winner Kelly Clarkson hasn't been shy when it comes to commenting on the show that catapulted her into stardom. Since Steven Tyler and Jennifer Lopez announced their exits from the show, Clarkson has been vocal as to whom she'd like to see fill the judges seats. And now that Mariah Carey has secured one of the vacant seats, Clarkson has sounded off.
'American Idol' will see a new set of judges next year, and while Mariah Carey has officially signed on to fill Jennifer Lopez's spot, two other seats remain. Now, rumor has it that Nick Jonas and Pharrell Williams are contenders for the panel.
Want to relive some of the fun from the American Idol 2012 Tour stop in Lafayette, Louisiana? A friend who was lucky enough to be on the front row shared some of her great photos with me...
The Cajundome was electric last night for the American Idol 2012 Concert and the Idols did not disappoint. The packed house swooned over Phillip Phillips and Colton Dixon but they screamed over Joshua Ledet. All in all, the show was entertaining and fun, but there was no question that Joshua was 'home.'
It's down to the wire! The American Idol Tour, featuring Louisiana's own Joshua Ledet, hits the stage at the Cajundome tonight! KTDY has one last chance for you to win tickets.
We still can't get over the fact that the No. 1 diva herself Mariah Carey has agreed to be a judge on 'American Idol.' Of course, with a price tag of $18 million, we're not terribly surprised, but we have a sneaking suspicion she agreed because she feels the need to compete with veteran competitors like 'X Factor' judge Britney Spears and 'The Voice' judge Christina Aguilera.
American Idol has just released more seats for the American Idol Live 2012 perfomance this Monday night in the Cajundome.
With Steven Tyler and Jennifer Lopez both out for the next season of 'American Idol,' speculation continues to swirl about who might replace them. Original 'Idol' champ Kelly Clarkson says she's not interested in the job, but she would like to see Season 4 winner Carrie Underwood get a shot.
After a "spring cleaning" of sorts of the 'America Idol' judges' table, Fox has made the news official that R&B diva Mariah Carey will be coming on to judge the talent during the upcoming season 12.


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A Full-Period Generating Mode for Bearingless Switched Reluctance Generators
ABSTRACT A bearingless switched reluctance generator (BSRG) is developed, which is operated in full-period generating mode. In the proposed 12/8 bearingless generator, two sets of windings are embedded in the stator. The coils of excitation winding wound on each stator pole are separately controlled, whereas the coils of generation winding are connected in series for each phase. To begin with, the voltage equations of the generator are built for the dynamic analysis model. Then, the mathematical model of radial force is derived for the control of the unbalanced magnetic force. Furthermore, a control algorithm is introduced to generate the required radial forces and output voltage. Finally, dynamic analysis results are included to verify the proposed analysis.
- SourceAvailable from: ocean.kisti.re.kr
- "So far, there are mainly two kinds of methods to work it out. One is that the additional set of conditional windings is wound on the stator core with the main windings [5] [6] [7] [8]. It needs two sets of inverters to supply the currents to the torque-and suspension-winding respectively. "
Article: Analysis of Half-coiled Short-pitch Windings with Different Phase Belt for Multiphase Bearingless Motor[Show abstract] [Hide abstract]
ABSTRACT: The analysis and comparation of the half-coiled short-pitch windings with different phase belt are presented in the paper. The half-coiled short-pitch windings can supply the odd and even harmonics simultaneously, which can be applied in multiphase bearingless motor (MBLM). The space harmonic distribution of the half-coiled short-pitch windings with two kinds of phase belt is studied wi th respect to different coil pitch, and the suitable coil pitch can be selected from the analysis results to reduce the additional radial force and torque pulse. The two kinds of half-coiled short-pitch windings are applied to the five- and six-phase bearingless motor, and the comparation from the Finite Element Method (FEM) results shows that the winding with phase belt is fit for the five phase bearingless motor and the winding with phase belt is suitable for the six phase bearingless motor. Finally, a five phase surface-mounted permanent magnet (PM) bearingless motor is built and the experimental results are presented to verify the validity and feasibility of the analysis. The results presented in this paper will give useful guidelines for design optimization of the MBLM.Journal of Electrical Engineering and Technology 01/2014; 9(1). DOI:10.5370/JEET.2014.9.1.162 · 0.53 Impact Factor
Article: A Practical Drive System with Accurate Rotor Position Detection for a Switched Reluctance Motor[Show abstract] [Hide abstract]
ABSTRACT: This work has been made to achieve two goals. The first is to introduce a reliable operation by determining the least inductance of windings to start the motor from an unaligned position, based on three-pulse injection to the motor windings. The second is to enhance the performance of the whole system. This is done by vibration and harmonic reduction based on the delay angle between firing sequence pulses train. This work implements accurate rotor position estimation, which is very important for the performance operation of the switched reluctance motor. The key principle of the rotor position estimation is based on detecting and comparing of phase voltage and current responses relating to the stator inductance varied with the position of the rotor pole (maximum inductance when it is aligned and minimum inductance when it is unaligned). Experimental results are presented to verify the proposed method.ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING 10/2013; 38(10). DOI:10.1007/s13369-013-0596-z · 0.37 Impact Factor
Conference Paper: Study on Switched Reluctance Generator for Rural Electrification[Show abstract] [Hide abstract]
ABSTRACT: This paper addresses the need for the utilization of cost effective, maintenance free electric machines in stand alone wind energy conversion system meant for rural areas. The suitability of switched reluctance machine as generator for stand alone rural wind energy conversion system has been explored through design and analysis. The design procedure, selection of pertinent topology, static and transient magnetic characteristics has been presented. Finite element analysis has been extensively used to refine as well as to analyze the finalized design.Industrial and Information Systems (ICIIS), 2009 International Conference on; 01/2010


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October 04, 2015
04 Dec 2013
Playbill.com's feature series Their Favorite Things asks members of the theatre community to share the Broadway performances that most affected them as part of the audience.
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text: Really nice hotel. Off the highway. Somewhat unique. You park in the back of e complex. Just the entry in the front. Hotel is clean and staff was friendly. Got the room for 109 a night. Room was really awesome. Very modern. Loved the layout. Fridge. Freezer and Microwave. Internet worked great. They do have a food pantry. Prices are very high. Quiet nights sleep and a wonderful breakfast to start off the day.


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Cancer-related fatigue: Links with inflammation in cancer
patients and survivors
Julienne E. Bower, Ph.D.
UCLA Departments of Psychology and Psychiatry and Biobehavioral Sciences
Fatigue is one of the most common and distressing side effects of cancer and its treatment and
may persist long after successful treatment completion. Emerging evidence suggests that
inflammatory processes may be involved in cancer-related fatigue both during and after treatment.
In this review, we consider the evidence for an association between inflammation and fatigue in
cancer patients and survivors. Further, we identify potential mechanisms for persistent
inflammation, focusing on the HPA axis. Risk factors and treatments for cancer-related fatigue are
also discussed.
1. Introduction
There are a growing number of cancer survivors in the United States, and a concomitant rise
in attention to quality of life after cancer diagnosis and treatment. In particular, behavioral
side effects of cancer treatment have become a focus of research and clinical attention. The
most common and distressing side effect of cancer treatment is fatigue (Lawrence et al.,
2004). Fatigue occurs across different types of cancer and cancer treatments and may persist
for months or years after successful treatment completion. In addition to its importance for
patients' well-being, cancer-related fatigue is of interest as a potential clinical model of
sickness behavior that may provide valuable insight into proinflammatory cytokine effects
on the brain and behavior. This review will consider the evidence for a link between
inflammation and cancer-related fatigue, focusing on research conducted by our group with
breast cancer patients and survivors.
2. Prevalence and description of cancer-related fatigue
Prevalence estimates of fatigue during treatment range from 25% to 99%, depending on the
patient population and type of assessment. Most studies find that 30% to 60% of patients
report moderate or severe fatigue while undergoing treatment with radiation, chemotherapy,
hormone therapy, and biological therapies (Lawrence et al., 2004). A substantial minority of
these patients continue to experience problems with fatigue long after treatment completion.
In a large cohort study, we found that approximately one-third of disease-free breast cancer
survivors reported fatigue at 1 to 5 and at 5 to 10 years post-diagnosis; 21% reported
problems with fatigue at both assessments (Bower et al., 2000; Bower et al., 2006). Similar
estimates have been obtained in other survivor populations (Cella et al., 2001).
© 2007 Elsevier Inc. All rights reserved.
Address correspondence to: Julienne E. Bower, Ph.D. UCLA Cousins Center for Psychoneuroimmunology, 300 UCLA Medical Plaza,
Room 3306, Box 957076, Los Angeles, CA 90095-7076, Phone: 310-794-9383; Fax: 310-794-9427, firstname.lastname@example.com.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our
customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of
the resulting proof before it is published in its final citable form. Please note that during the production process errors may be
discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
NIH Public Access
Author Manuscript
Brain Behav Immun. Author manuscript; available in PMC 2013 April 19.
Published in final edited form as:
Brain Behav Immun. 2007 October ; 21(7): 863–871. doi:10.1016/j.bbi.2007.03.013.
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Qualitative reports suggest that cancer-related fatigue differs from "normal" fatigue due to
lack of sleep or overexertion as it is more severe, longer lasting, and is not relieved by
adequate sleep or rest (Poulson, 2001). Empirical studies have confirmed that the intensity
and duration of fatigue experienced by cancer patients and survivors is significantly greater
than healthy controls (Andrykowski et al., 1998; Jacobsen et al., 1999). Fatigue has a
detrimental impact on all aspects of quality of life among both cancer patients and survivors.
For example, in a nationwide survey of cancer patients over 50% reported that fatigue
affected their ability to work, their physical and emotional well-being, their social activity,
and their ability to enjoy life in the moment (Curt et al., 2000).
Assessment of cancer-related fatigue is challenging as there is no commonly agreed on
definition of this symptom (Jacobsen, 2004). One definition that captures several of the key
features of cancer-related fatigue describes fatigue as "a subjective state of overwhelming
and sustained exhaustion and decreased capacity for physical and mental work that is not
relieved by rest" (Cella et al., 1998). As indicated by this definition, fatigue is thought to be
a subjective phenomenon and thus self-report measures are currently the gold standard for
fatigue assessment. Numerous instruments are used to assess cancer-related fatigue,
including items and subscales from mood and quality of life measures as well as
multidimensional scales that were developed and validated specifically for cancer patients.
A structured interview has also been developed to ascertain the presence of a clinical
syndrome of cancer-related fatigue based on a set of diagnostic criteria, although this is not
yet widely used.
3. Etiology of cancer-related fatigue
Fatigue is a non-specific, multidimensional symptom that is likely influenced by multiple
factors that coexist and vary in influence depending on individual characteristics of the
patient. Fatigue is not linked to a specific type of cancer or cancer therapy, although patients
with advanced cancer and those undergoing chemotherapy typically report more severe
fatigue. Psychosocial factors are strongly correlated with fatigue, including depression,
anxiety, and coping style (Andrykowski et al., 2005; Lawrence et al., 2004). Demographic
factors, physical symptoms, and comorbid medical conditions have also been identified as
correlates of fatigue (Bower et al., 2000; Lawrence et al., 2004). Although there is much
speculation about the role of biological factors in cancer-related fatigue, empirical research
has been extremely limited. Indeed, among the biological parameters evaluated to date (i.e.,
hemoglobin, albumin, thyroid hormone), none fully account for fatigue during or after
cancer treatment.
There is growing interest in the role of proinflammatory cytokines and the cytokine network
in cancer-related fatigue. Basic research on neural-immune signaling in animal models has
shown that peripheral proinflammatory cytokines signal the central nervous system and
exert potent effects on behavioral processes, including reduced activity, reduced social and
sexual behavior, reduced food and water intake, altered sleep, increased pain sensitivity and
reactivity, and cognitive alterations (Dantzer, 2001). Conversely, antagonists or synthesis
blockers of cytokines abolish these effects. In humans, less is known about the behavioral
effects of cytokines, although there is evidence that acute induction of cytokines in healthy
individuals has behavioral effects (Reichenberg et al., 2001; Spath-Schwalbe et al., 1998).
There is also evidence of cytokine alterations in behavioral disorders, particularly depression
(e.g., Miller et al., 2002).
In the context of cancer, it is well known that treatment with pharmacologic doses of
cytokines (i.e., IFN-α, IL-2) leads to fatigue and other sickness behaviors (Valentine et al.,
1998). It is possible that cytokines may also contribute to fatigue in patients who are not
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receiving immunotherapy. Proinflammatory cytokines interleukin 1 beta (IL-1β), interleukin
6 (IL-6), and tumor necrosis factor alpha (TNF-α) may be released in response to the tumor
or to cancer treatments and may continue to be expressed long after treatment completion.
These findings provide a physiological basis for examination of cytokine-fatigue links in
cancer patients and survivors.
At the behavioral level, there is ample evidence that cancer-related fatigue is associated with
other sickness behaviors. Our initial research on cancer-related fatigue focused on
demographic, medical, and behavioral correlates of fatigue in breast cancer survivors.
Fatigue was assessed in a large cohort of women (n = 1957) who had been diagnosed with
breast cancer between 1 and 5 years earlier and had completed local and/or adjuvant cancer
therapy (Bower et al., 2000). In multivariate analyses, the three strongest correlates of
fatigue status were depressed mood, pain, and sleep disturbance. These results were
replicated in a follow-up study with a subset of this cohort (n = 763) who were re-assessed
between 5 and 10 years post-diagnosis (Bower et al., 2006). At this time point, depressed
mood and pain were again associated with fatigue; moreover, depression at the initial
assessment predicted fatigue at the long-term follow-up. These findings are consistent with
previous research and led us to more directly examine the role of inflammatory processes in
cancer-related fatigue.
4. Fatigue and inflammation during radiation therapy
To test the hypothesis that activation of inflammatory cytokines is associated with fatigue
onset during cancer treatment, we recently conducted a study among early stage breast and
prostate cancer patients undergoing radiation therapy (Bower et al., 2007). Radiation
provides an interesting model in which to examine links between inflammation and fatigue
for several reasons. First, radiation is a mainstay of cancer treatment and is known to elicit
symptoms of fatigue. Second, exposure to radiation initiates a programmed molecular and
cellular response designed to promote tissue repair that includes activation of
proinflammatory cytokines (Stone et al., 2003) and there is evidence of elevated cytokine
levels in patients with breast and prostate cancer undergoing radiation therapy (Petrini et al.,
1992). Finally, localized radiation for early stage breast and prostate cancer is associated
with less toxicity than chemotherapy, minimizing the potential for confounding effects on
fatigue (e.g., nausea, anemia).
The association between proinflammatory cytokines and fatigue during radiation therapy has
been examined in a handful of previous reports, with mixed results. An early study
conducted with prostate cancer patients documented increases in fatigue and serum levels of
IL-1β during radiation therapy (Greenberg et al., 1993), and fatigue was positively
correlated with serum levels of IL-6 and other inflammatory markers in a more recent study
of breast cancer patients undergoing radiation, although this association appeared to be
mediated by body mass index (Wratten et al., 2004). Other studies have shown increases in
fatigue but no changes in serum levels of proinflammatory cytokines among women
undergoing radiation therapy for breast (Geinitz et al., 2001) or uterine cancer (Ahlberg et
al., 2004), and no correlation between fatigue and cytokine levels (Geinitz et al., 2001).
These mixed results may be due to constraints of the respective study designs (e.g., small
sample sizes, use of non-standard measures to detect cytokine levels; Ahlberg et al., 2004)
as well as the focus on cross-sectional associations between cytokine levels and fatigue. This
approach may not adequately capture the dynamic changes in these systems that occur over
the course of treatment, or individual differences in baseline levels of cytokines or fatigue.
To address these concerns, we elected to examine within-subject relationships between
fatigue and cytokines at multiple time points during treatment using hierarchical linear
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This study included 49 patients diagnosed with early stage breast (n = 28) or prostate (n =
21) cancer who had completed surgery and had not been treated with chemotherapy. Patients
were assessed before onset of radiation therapy and at 4 time points during treatment (at
week 1, 2, 4, and the final week of treatment, which was typically week 6). Self-reported
fatigue and circulating concentrations of IL-1β and IL-6 were measured at each assessment.
We tested two possible pathways through which proinflammatory cytokines might influence
fatigue. Expression of proinflammatory cytokines during radiation therapy is thought to
occur in waves, which should result in periodic peaks in cytokine levels during treatment
(Herskind et al., 1998). These peaks may lead to acute increases in fatigue, similar to effects
seen in experimental cytokine induction studies. On the other hand, exposure to cytokines
over the course of treatment may have more cumulative effects on fatigue. To evaluate this
pathway, we constructed a cumulative cytokine index that provided a measure of total
cytokine exposure at each assessment. For example, cumulative IL-6 at Week 2 was the sum
of (baseline IL-6) + (Week 1 IL-6) + (Week 2 IL-6) levels.
There was a steady increase in fatigue over the course of treatment for both breast and
prostate cancer patients, consistent with previous research. Moreover, there was a positive
association between cumulative cytokine exposure and fatigue. As cumulative levels of
cytokines increased, there was a corresponding increase in the number of days fatigued in
both patient groups. At the individual patient level, this suggests that as patients experienced
more frequent or more robust peaks in cytokine concentrations during treatment they
reported a greater increase in fatigue symptoms. We found no association between acute
changes in cytokine concentrations and changes in fatigue, perhaps because cytokine
concentrations were not sufficiently elevated at any individual assessment point to elicit
increases in fatigue.
Fatigue co-occurred with depressed mood and sleep disturbance among patients undergoing
radiation therapy, consistent with research conducted with cancer survivors (Bower et al.,
2000). Because depression and sleep disturbance have both been associated with elevations
in proinflammatory cytokines, we conducted analyses to determine whether these variables
might account for the association between cytokines and fatigue. Neither depressed mood
nor sleep disturbance was associated with cumulative cytokine exposure (or transient
changes in cytokines), and the association between cytokines and fatigue remained
significant after controlling for these variables. Moreover, cumulative cytokine exposure
was a significant predictor of fatigue in analyses controlling for other potential confounds,
including age, body mass index, and use of alcohol and caffeine.
Overall, results from this study support the hypothesis that exposure to proinflammatory
cytokines during radiation therapy is associated with subjective reports of fatigue. Further,
the association between proinflammatory cytokines and fatigue was apparent in both breast
and prostate cancer patients, suggesting that activation of the proinflammatory cytokine
network may be a non-specific mediator of fatigue in different cancer populations. Of
course, the observational nature of this study does not allow us to draw conclusions about
causality, and it is possible that other factors may mediate or drive this association. The
association between cytokines and fatigue was evident only in within-subject analyses that
focused on cumulative cytokine exposure, suggesting that it may be necessary to utilize
analytic approaches that reflect the dynamic nature of immune responses when evaluating
relationships with behavioral variables during treatment.
5. Fatigue and inflammation in cancer survivors
As mentioned above, fatigue continues long after successful treatment completion in
approximately one-third of cancer survivors (Bower et al., 2000; Cella et al., 2001).
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Persistent fatigue typically cannot be explained by underling medical or psychiatric
problems or treatment-related biological changes such as anemia. We have conducted
several studies to test the hypothesis that post-treatment fatigue in breast cancer survivors is
associated with elevated inflammatory processes. This research has focused on women who
were initially diagnosed with early stage breast cancer (Stage 0, I, or II), have completed
cancer treatment with the exception of hormonal therapies, and show no evidence of residual
or recurrent disease, thus reducing the possibility that disease-related processes might be
driving persistent inflammation. Further, participants have no chronic or recurrent medical
conditions that involve the immune system or regular use of immunosuppressive
medications. We have identified fatigued survivors based on their responses to the vitality
subscale of the SF-36; women had to score below 50 on this scale (indicating limitations or
disability related to fatigue) on at least two occasions after cancer diagnosis and treatment in
order to be classified as fatigued.
In our first report, we recruited 20 breast cancer survivors with persistent post-treatment
fatigue and a control group of 20 non-fatigued survivors (Bower et al., 2002). Women in this
study had been diagnosed with breast cancer between 3 and 7 years earlier. Consistent with
hypotheses, fatigued survivors showed significantly higher levels of soluble inflammatory
markers than non-fatigued controls, including elevations in IL-1ra, sTNF-RII, and neopterin.
No differences in IL-1β were observed, although levels were undetectable for almost half of
the study participants. Fatigued women also reported a number of other sickness behaviors,
including depressed mood, decreased activity level, decreased social interest, and cognitive
problems (i.e., forgetfulness, distractibility). However, the association between fatigue and
inflammatory markers remained significant in analyses controlling for depression and other
potential confounds. There were no differences between fatigued and nonfatigued survivors
in the type of cancer treatment received or in the length of time since diagnosis and
We also examined cellular immune status in these patients to determine whether elevations
in soluble inflammatory markers might stem from alterations in the cellular immune
response (Bower et al., 2003). Indeed, fatigued survivors showed a 31% increase in
circulating T lymphocytes relative to non-fatigued controls, particularly CD4+ T
lymphocytes (41% increase) and CD56+ effector T lymphocytes (52% increase). These
effects remained significant after controlling for potential confounders including age, body
mass index, depressed mood, and treatment type. In contrast, no alterations in numbers of
circulating B cells, NK cells, granulocytes, and monocytes were observed. Elevations in T
cells were correlated with elevations in serum levels of IL-1ra, suggesting that a T cell
mediated inflammatory process might be driving fatigue symptomatology via systemic
distribution of cytokines.
We recently replicated and extended these findings in a larger cohort of 50 breast cancer
survivors, including 32 women with persistent fatigue and 18 nonfatigued controls (Collado-
Hidalgo et al., 2006). Consistent with our previous report, fatigued survivors showed
elevations in soluble markers of proinflammatory cytokine activity, including IL-1ra and the
soluble IL-6 receptor (sIL-6R). Increases in plasma sIL-6R were accompanied by significant
reductions in cell surface expression of IL-6R on CD14+ monocytes among fatigued
participants. Decreased cell surface expression of IL-6R is thought to reflect cytokine-
induced receptor shedding, and in vitro studies confirmed that exposure to proinflammatory
cytokines was associated with loss of IL-6R from the cell surface of PBMCs. Analysis of the
cellular immune system revealed decreases in the frequency of circulating monocyte
dendritic cells and activated T cells among fatigued survivors, as well as a selective increase
in CD4+ T lymphocytes. All of the relationships between fatigue and immune variables
remained significant in analyses controlling for potential confounds.
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I would not mess with that man.
He was arrested in Sanger TX which is 55 miles north of Dallas.
And only a few miles from his house just off Richland Chambers lake. Awesome looking place.
I like how the Dallas people need to insist this happened somewhere else. "We don't cotton to the celebrity shenanigans they put up with in L.A. This here is God's countr—dammit, Khloe!!"
I don't care whether it's Dallas or anywhere else. To say he was arrested in Dallas instead of the actual town is just flat out lazy reporting. Fish just grabbed the headline from TMZ.
Like the dog in the ads for the humane society that no one wants to adopt.
(glances at cut-out magazine photo of Chris Hansen, crushes in fist, looks up at mirror)
"Wait'll he gets a load of me."
The fascinating thing is that genetically he's 99.5% the same as a human. Eat THAT creationists!
The things a guy has to do to keep cred in the Honky Tonkin' 'hood…
Someone should tell Superman about Brainac being arrested.
…and THAT's why old women sit & talk about old men.
Giving Lyle Lovett a run for his cartoon-faced money.
Guess his pick-up truck left him.
Motherfucker look like a serial killer.
This guy was totally hard on Level 6 of Mike Tyson's Punchout.
Hanging out in front of Baptist churches with a bottle of wine is actually a pretty good way to pick up dudes.
obviously he got publicly intoxicated from some fava beans and a nice chianti- th-th-th-th-th-th-.
His face is a travisty.
That one tune of his, "Old 8 x 10," was evidently about his forehead.
Was the driving the ice cream truck from the movie 'Legion'?
Nothing says 'country bad-ass' like a steel plate holding the bridge of your nose together.
Neil Patrick Harris, this is your future


text:
This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Recent Indio reviews
"A very nice and comfortable home to spend multiple months in. Close to Mountain View clubhouse and convenient to shopping center nearby. Homeowners are very accommodating and responsive to emails. Bed and living room furniture very comfortable. The golf cart was very much appreciated for golf and for getting around Sun City. Definitely recommend renting this property."Guest: LELady Date of Stay: January 2015 Review Submitted: April 5, 2015View listing
"Rancho La Quinta is a highly exclusive gated community ideally situated in the La Quinta area. We have stayed at this resort for the last 2 years. This home is an absolute jewel! With 3 bedrooms (all king beds) and one single bed in one of the guest bedrooms, it is ideally set for entertaining family and friends. The decor is beautiful, clean and uncluttered, with high ceilings, marble floors and a gourmet kitchen which lacks for nothing. The gas fireplace in the great room is a very welcome feature on some of those cool desert evenings. The pool/spa and patio are of an ideal size, with a spectacular view, looking over a fairway on one of the golf courses to the mountains beyond. The owners were a pleasure to deal with - honest, reliable and prompt. We were given an excellent orientation to the house when we arrived by the owner's agent who lived in the resort for many years - it was quite the best orientation to a rental property that we have ever had, and the agent was always quick to respond to any questions that we had during our stay. The northern exposure of this house is the preferred exposure in this resort as it protects from any winds and avoids the low late afternoon sun 'lasering' into the house! The location is excellent for shopping with Costco about 5 minutes away and Whole Foods, Bristol Farms and El Paseo Drive about 15 minutes. We can highly recommend this home without reservation - a true jewel!"Guest: Anonymous Date of Stay: November 2014 Review Submitted: December 7, 2014View listing
Featured Destinations: Lake Almanor, Orlando Vacation Rentals, Big Bear Cabin Rentals, Anna Maria Island Rentals


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In a landmark agreement, the South Coast Air Quality Management District (SCAQMD) reached a "government-to-government" agreement with the Cabazon Band of Mission Indians to enforce some of the SCAQMD's air quality regulations on tribal land.
The SCAQMD is the air pollution control agency for all of Orange County and the urban portions of Los Angeles, Riverside and San Bernardino Counties, but does not have jurisdiction over tribal lands. Under the agreement announced yesterday, the tribe has voluntarily agreed to allow the SCAQMD inspectors to conduct air sampling, monitoring and inspection activities on the 640-acre Cabazon Resource Recovery Park industrial park near Mecca. It also requires facilities operating within the park, including Western Environmental Inc., to comply with applicable SCAQMD rules. The agreement will also allow the SCAQMD to enforce permits issued by the U.S. Environmental Protection Agency to facilities operating within the park...
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Sway: You had a lot of supporters outside the courthouse every single day. Tell me why are fans so important to P. Diddy and his career.
Combs: Fans made me. The fans gave me a chance, and they made me. Beyond that, my career has been trials and tribulations and ups and downs, so I have to have true fans riding with me. People [who] weather the storm, ride with me through the dark times and the sunlight times, the up times and down times I appreciate them for that. When you are down on the ground and somebody is extending their hand to you, it just gives you hope. Usually when you are going through something real bad, ain't nobody there. I had fans there, and it made me feel so good.
There were fans that were outside [the courthouse] the whole time. When the verdict came down, it was just packed with press and fans, and they [kept] the fans real separate. They did not let them be close, because they did not know who was in the crowd, for security purposes. When I was leaving, I had to go and hug them all. I just saw it in their faces that they were happy; they were as happy as me. I saw men with tears in their eyes. I just wanted them to know that I am approachable. I ain't untouchable. I am blessed and fortunate, and I am grateful to be here. This is not [me saying] "I got over another one." This really shook me up. See, people that really cared, I just wanted to dive on them. I wanted to let them know that they are really appreciated.
Sway: What was the most memorable thing that a fan has done for you in your career?
Combs: I have been blessed with some of the best fans. I have had fans make me the big picture collages of the photo books; I have had fans send me birthday cakes [and] sing to me on my voicemail. I have had fans flash me. I have had older fans give me their bras and underwear onstage. I think the biggest thing is fans praying for me sincere prayers during hard times. Beautiful letters of words of support. Fans making tapes of them doing songs, and fans crying. The most touching thing is fans crying. That really bugs me out. You'll be like, "Please, don't do that, it makes [me] feel so uncomfortable right now," but it just feels so good and makes you cry. I have had some of the greatest fans.