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Inflammation, Vol. 27, No. 4, August 2003 (C ? 2003)
Nitric Oxide Modulates MCP-1 Expression in Endothelial
Cells: Implications for the Pathogenesis of Pulmonary
Granulomatous Vasculitis
Anjali Desai,1Mark J. Miller,1Xiaodong Huang,1and Jeffrey S. Warren1,2
Abstract—Monocyte chemoattractant protein-1 (MCP-1) is a pivotal mediator of angiocentric gran-
uloma formation in glucan-induced pulmonary granulomatous vasculitis. Based on the rationale that
mononuclear phagocytes retrieved from granulomas are rich sources of nitric oxide (NO) and that the
recruitment of mononuclear phagocytes into lesions abates as granuloma formation slows, we tested
the hypothesis that MCP-1 gene expression is regulated by a NO-sensitive mechanism. Preexposure
of endothelial cell (EC) monolayers to NO donor compounds markedly reduced cytokine-induced
fluctuations in endothelial reduced glutathione (GSH) pools but did not affect cGMP concentrations.
The lungs of mice bearing targeted disruptions of the inducible nitric oxide synthase (iNOS) gene
exhibited significantly higher concentrations of MCP-1 following glucan infusion than did those of
wild-type mice. Cumulatively, these data suggest that NO suppresses MCP-1 expression by blunting
the redox changes associated with cytokine-induced EC activation.
KEY WORDS: monocyte chemoattractant protein-1; pulmonary granulomatous vasculitis; nitric oxide; endothe-
lial cells; iNOS knockout mice.
Pulmonary granulomas develop in response to a va-
riety of microbial agents (eg. Mycobacterium tuber-
culosis), inhaled foreign particulates (e.g. metal dusts
such as beryllium), and etiologically unknown factors
(e.g. Wegener's granulomatosis, sarcoidosis) (1). Sev-
eral forms of pulmonary granulomas are characterized
by monocyte/macrophage-rich collections of inflamma-
tory cells centered around blood vessels (i.e. angiocen-
tric). Monocyte chemoattractant protein-1 (MCP-1), a
member of the C-C or beta subfamily of chemokines
Arbor, Michigan.
2To whom correspondence should be addressed at Department of
Pathology-Box 0602, University of Michigan Medical School, 1301
Catherine Road, Ann Arbor, Michigan 48109-0602. E-mail: warren@
has been identified as a pivotal mediator of granu-
loma formation. Secreted by a variety of cell types, in-
cluding endothelial cells (ECs), smooth muscle cells,
fibroblasts, and monocytes, MCP-1 induces monocyte re-
cruitment and activation, and can upregulate adhesion
molecule expression and cytokine production by mono-
cytes (2). Monocyte chemoattractant protein-1 can acti-
burst (3).
MCP-1 expression is obligatory for lesion development
in a rodent model of pulmonary granulomatous vasculitis
(4). In this model, the intravenous infusion of particulate
yeast cell wall glucan results in the rapid, synchronous
fully mature, are composed primarily of monocytes and
macrophages. Recent studies indicate that the upregu-
lation of MCP-1 is, in part, regulated by the cytokines
TNF-α and IL-1β (5). MCP-1 expression during the
C ? 2003 Plenum Publishing Corporation
Page 2
Desai, Miller, Huang, and Warren
pathogenesis of glucan-induced granuloma formation is
biphasic with an early (1 h) blood-vessel wall associated
rise in MCP-1 and a later (6–24 h) rise in MCP-1
associated with granuloma cells per se (6). Experiments
in which neutrophils have been either selectively de-
pleted or their adherence to vascular wall endothelium
inhibited by means of infused sialyl-Lewis glycomimetic
P-selectin antagonists have revealed that neutrophils
are obligatory for full granuloma development even
though they are not present in definitive lesions (48–96 h)
(7, 8). These observations, coupled with evidence that
the infusion of catalase inhibits granuloma formation
and that pharmacologic modulation of intracellular
glutathione redox status modulates MCP-1 expression
in granulomatous vasculitis, support the hypothesis that
neutrophils and locally produced H2O2 are important
mediators of monocyte recruitment (9).
While there is extensive evidence suggesting that
the expression of proinflammatory mediators including
MCP-1, is redox sensitive, the intracellular mediators and
transduction pathway(s) are complex and incompletely
locally produced NO regulates the expression of endothe-
of glucan-induced granulomatous vasculitis rests on evi-
dence that mononuclear phagocytes in pulmonary lesions
release NO discretely at sites of granuloma formation. In
this scenario, NO may temporally and anatomically de-
limit the extent of an evolving granulomatous lesion by
either down-regulating further MCP-1 elaboration and/or
by preventing MCP-1 expression in vessel wall cells ad-
jacent to the lesion. In the present context, "delimitation"
indicates the cessation of net "growth" of a granuloma.
ment of an individual granuloma must reach a maximum
size before it begins to then "resolve". The in vitro data
presented suggest that locally produced NO may regu-
late endothelial MCP-1 expression by blunting cytokine-
and/or reactive oxygen intermediate-induced changes in
cellular redox status.
Unless otherwise specified, materials were pur-
chased from Sigma Chemical Company (St. Louis, MO).
NONOates were purchased from Cayman Chemicals
(Ann Arbor, MI). Mice were obtained from Jackson Lab-
oratories (Bar Harbor, ME).
Endothelial Cell Culture
Human umbilical vein endothelial cells (HUVECs)
were isolated from umbilical cords as previously
described (11).
Treatment of HUVECs for Enzyme Immunoassay
(EIA) Experiments
Aqueous solutions of NO were generated using
NONOate compounds. NONOates are nucleophilic NO
adducts that spontaneously decompose at neutral pH to
release NO (12). As indicated in the results, we em-
ployed combinations of two short half-life NO donors,
Methylamine hexamethylene methylamine (MAHMA)
NONOate (t1/2= 1 min at 37◦C) and Diethylamine
(DEA) NONOate (t1/2= 2 min at 37◦C), or Dipropy-
lenetriamine (DPTA) NONOate (t1/2= 3 h at 37◦C) for
longer sustained release. NONOate stock solutions were
prepared in 0.01 N NaOH and then diluted into M199
medium to initiate NO release. After a 30-min exposure
to NO, HUVECs were stimulated with either TNF-α or
IL-1β(1 ng/mL) for 8 h. The conditioned media collected
at the end of this 8-h incubation period were subjected to
the EIA experiment in a cytotoxicity detection (LDH) as-
always ≥95%.
MCP-1 Enzyme Immunoassay (EIA)
MCP-1 EIAs were carried out as previously
decribed (13).
Ribonuclease (RNase) Protection Assay
Total RNA was extracted from endothelial cells
using Tri Reagent according to manufacturer's in-
structions. The RNase protection assays were per-
formed using the RiboQuant Multi-probe kit from
described (13).
Extraction of Nuclear Protein
Nuclear extracts were prepared and protein concen-
trations determined as previously decribed (9, 14).
Page 3
Nitric Oxide Modulates MCP-1 Expression in Endothelial Cells
Electrophoretic Mobility Shift Assay
Electrophoretic mobility shift assays (EMSAs) were
carried out as previously described using a gel shift assay
system kit (Promega, Madison, WI) (11).
Glutathione Assay
Oxis International (Portland, OR) following the manu-
facturer's instructions. Briefly, cells were washed with
phosphate buffered saline (PBS) and homogenized in ice-
cold 5% metaphosphoric acid. The homogenate was cen-
assay. Reduced glutathione (GSH) was utilized as a stan-
dard. Spectrophotometric determinatons were performed
of 405 nm.
Induction of Pulmonary Granulomatosis
Glucan-induced pulmonary granulomatous vasculi-
tis was induced in BL6 mice or iNOS knockout mice as
(Sigma) was suspended in phosphate bufferered saline
(5 mg glucan in 1 mL of PBS). The suspension was son-
icated, vortexed, and 100 µL were infused slowly via the
heat-dilated tail vein. Control animals received vehicle
(PBS) only. At specified intervals following glucan ad-
ministration, animals were euthanized and their lungs and
hearts removed en bloc. One lung was instilled with 10%
PA), followed by processing for light and electron mi-
croscopy. The other lung was immediately snap-frozen
in liquid nitrogen and subsequently processed for use in
EIAs of tissue extracts.
cGMP Assay
Assay Designs (Ann Arbor, MI) according to manufac-
in 24-multiwell plates were washed with HBSS to re-
move traces of serum. The cells were incubated with the
indicated test compounds for 15 min and subsequently
1 mM isobutylmethylxanthine (IBMX) was added to in-
hibit the phosphodiesterases (5-min incubation). Hank's
balance salt solution (HBSS) was then aspirated and
250 µL of 0.1 N hydrochloric acid (HCl) were added
to each well to stop enzymatic reactions and to extract
cGMP. After 30 min, the HCl extract was collected and
tein content in each well was measured by the Bradford
method after solubilization with 1 N sodium hydroxide
Densitometric Scanning
Autoradiographs from RNase protection assays and
EMSAs were scanned using Polaroid PhotoMAX Pro and
integrated densities were determined using Scion Image
for windows (Scion Corporation, Frederick, MD). To ad-
just for differences in sample loading between wells in
the RNase protection assay, MCP-1 mRNA levels were
expressed as ratios of integrated densities for MCP-1 to
GAPDH products.
Statistical Analysis
Statistical analysis was performed using SAS, ver-
sion 8.2 (SAS Institute). All values are expressed as the
variance (ANOVA).(15) Probability (p) values of <0.05
were considered significant.
Exogenous NO Suppresses Cytokine-Induced
MCP-1 in HUVECS
Exposure of HUVECs to either TNF-α or IL-1β re-
sulted in dose-dependent increases in MCP-1 production
(Fig. 1). When cytokine-activated cells were pretreated
NONOate (t1/2= 1 min at 37◦C) (50 µM) and DEA
NONOate (t1/2= 2 min) (50 µM), significant reductions
in secreted MCP-1 concentrations were observed. These
effects were not observed when the NO donor compound
and the cytokine were added simultaneously or when NO
exposure followed cytokine stimulation (data not shown).
NO(t1/2= 3hat37◦C)(50µM)wassubstitutedforDEA-
NO (data not shown). These data indicate that exposure
of HUVECs to chemically generated NO prior to stimu-
lation with TNF-α or IL-1β results in marked reductions
in MCP-1 production.
Page 4
Desai, Miller, Huang, and Warren
Fig. 1. Suppression of cytokine-induced MCP-1 by exogenous NO. HUVECs were treated for 30 min with medium alone (◦) or NONOate (?),
respectively, followed by a 12-h incubation period with either a) TNF-α or b) IL-1β. These data represent means ± SE of a single experiment that
is representative of four separate experiments. In each experiment, conditions were examined in triplicate. Asterisk∗denotes significant difference in
MCP-1 concentrations in presence and absence of NO donor.
NO Donors Suppress MCP-1 mRNA
in cytokine-induced MCP-1 protein secretion in response
to NO pretreatment were also associated with changes in
MCP-1 mRNA concentrations, we utilized a multi-probe
in either medium-treated HUVECs or HUVECs that had
been treated with a combination of MAHMA and DEA
NONOates (Fig. 2). As expected, exposure of HUVECs
to TNF-α or IL-1β (4 h) resulted in marked increases in
MCP-1 mRNA concentrations (Fig. 2). When cells were
treated with MAHMA and DEA NONOates prior to cy-
NO-mediated reductions in MCP-1 protein production in
HUVECs measured by EIA (Fig. 1) are accompanied by
reduced MCP-1 mRNA levels.
Exogenous NO Suppresses Cytokine-Induced NF-κB
Translocation but Does Not Affect AP-1 Activation
endothelial cells depends on the cooperative interaction
of the redox-sensitive transcription factors NF-κB and
MCP-1gene expressionin
AP-1 (16). We examined the activation of NF-κB and
AP-1 by EMSA (Fig. 3). Low concentrations of NF-κB
were detected in nuclear extracts derived from media-
treated cells (lane 1, Fig. 3A). As expected, cytokine
stimulation of HUVECs resulted in a marked increase in
the cytosolic-to-nuclear translocation of NF-κB (lanes 2
and 3, Fig. 3A). The activation of NF-κB was suppressed
by pretreatment with MAHMA and DEA NONOates
(lanes 5 and 6, Fig. 3A). No changes in the nuclear
concentrations of AP-1 were observed in endothelial cells
upon activation by cytokines (lanes 2 and 3 compared
to lane 1; Fig. 3B). Moreover, NO donors had no effect
on activation of AP-1 (lanes 4, 5, and 6; Fig. 3B).
These data indicate that cytokine-induced activation of
NF-κB but not AP-1, is sensitive to NO exposure. Since
NF-κB is a redox-sensitive transcription factor, these data
suggest that alterations of cellular redox status may be
mechanistically important in NO-mediated suppression
of endothelial MCP-1 production.
Exogenous NO Blunts Cytokine-Induced
Fluctuations in Endothelial Reduced
Glutathione (GSH) Concentrations
In order to further address the potential role of
changes in cellular redox status as a mechanism for
Page 5
Nitric Oxide Modulates MCP-1 Expression in Endothelial Cells
Fig. 2. Suppression of cytokine-induced MCP-1 mRNA concentrations by exogenous NO. HUVECs were treated for
30 min with medium (SFM) or a combination of MAHMA NONOate and DEA NONOate (50 µM each), followed by
a4-hincubationperiodwithTNF-α orIL-1β.RNaseprotectionassaywasutilizedinordertodetectspecifictranscripts
for MCP-1 and for the "housekeeping" genes, L32 and GAPDH, as controls. The data shown are representative of
three separate experiments.
NO-mediated suppression of MCP-1 expression, we ex-
amined the effects of cytokines and NO on cellular GSH
concentrations. TNF-α treatment of HUVECs resulted in
a 30% decrease in intracellular GSH concentration when
compared to cells treated with serum-free medium (SFM)
alone (Fig. 4A). Preexposure of HUVECs to NO partially
reversed this effect, restoring GSH concentrations to 93%
of the resting level (Fig. 4A). However, a more than 20%
increase in intracellular GSH pools from baseline was ob-
served in IL-1β-stimulated HUVECs (Fig. 4A). Incuba-
tionwithNOpriortoactivationwithIL-1β resultedinade-
crease in GSH concentrations to the basal level (Fig. 4A).
were prevented by preexposure of HUVECs to NO
Exogenous NO Does Not Modulate Cytokine-Induced
Endothelial cGMP Production
Nitric oxide exerts its relaxation effect on smooth
that in turn leads to increased intracellular concentrations
of cyclic GMP (cGMP).(17) To ascertain whether the ob-
served effect of NO on MCP-1 suppression is accom-
panied by increased cGMP levels, we treated HUVECs
with NO donor compounds and measured cellular cGMP


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Newly renovated rooms, contemporary furniture, new bathrooms with granite counter tops, a comfortable easy chair, in-room safes, and more. Free WiFi. Free coffeehouse-style coffee and tea. Pets stay free. Located near I-80 and Larkin Avenue & close to shopping & restaurants.
Super 8 Motel Galesburg
Super 8 Galesburg motel provides the value and convenience you need during your travels. Pull off Interstate 74 at the Knoxville exit 51, midway between the Quad Cities and Peoria, IL, to enjoy handy amenities like guest laundry and large-vehicle parking. Wake up in the morning to free SuperStart continental breakfast before hitting the road, and relax in the evening with free Wi-Fi and heated indoor pool. Book a suite with Jacuzzi, microwave and refrigerator. We are pet friendly and handicapped-accessible.
Microtel Inn & Suites
Inviting 64-room inn located at Stevenson Drive exit off I-55, with indoor pool, continental breakfast, guest laundry, smoke free environment.
Marriott Suites Deerfield
This hotel features suites with a private parlor room separated by French doors. Suites include a spacious bedroom with a separate living area with sleeper sofa, wet bar, microwave, refrigerator, coffee maker, Plug-In Panel to connect your laptop, iPod and camera to the 32" LCD, HD flat-screen TV and in-room movies. Enjoy the fitness center, indoor/outdoor pools, sauna, fitness trails, and area golf courses. Enjoy a delightful dining experience with friendly service, great food and an extensive menu in the Basil's Bistro, open for breakfast, lunch and dinner, located within the hotel, also offering room service. There are also 6 meeting rooms with 9,000 sq. ft. of flexible event space.
Country Inn & Suites - Galesburg
Country Inn & Suites is proud to offer guests comfortable accommodations and modern amenities, such as free high-speed, wireless Internet access, convenient meeting space, complimentary hot breakfast buffet, an indoor pool and an on-site Fitness Center. To ensure a pleasant stay, we also provide guests with a free weekday newspaper and guest laundry facilities. Be our guest and experience what sets us apart from other hotels in Galesburg, Illinois.
Mount Morris Motel
Nearest motel to White Pines, one level no stairs to climb, cable TV, A/C, eat, and 24 hour phone.
CITY:Mount Morris
Hampton Inn & Suites
Discover the cultural heartland of Illinois when staying at the Hampton Inn and Suites Danville. Our hotel provides easy access to I-74 and is minutes away from fishing, hunting and shopping. Explore the Vermilion County Museum and the Vermilion County War Museum. Hunt at the Kennekuk County Park featuring archery deer, turkey, waterfowl and upland game hunting. Visit the Forest Glen Preserve— an 1,800 acre nature preserve in Vermilion County or if you'd prefer to shop you'll find great deals in Danville's shopping district. Our hotel is only 10 miles away from tennis courts, a golf course and a basketball court. We're within 5 miles of local corporations such as Pepsico and Genpact.
Nauvoo Family Inn & Suites
Nauvoo Family Inn is a welcoming place. We want you to get the most out of your family vacation or Nauvoo wedding without stressing over your hotel situation. Check out our Rooms page for hotel amenities and room options. From our standard rooms with 2 queen beds, to our fully equipped family suites or bunk rooms; we are sure to accommodate families and groups of any size. We aren't just any old traditional family inn. We also provide an indoor heated swimming pool and additional services such as an on-site restaurant in a country style setting.
America's Best Value Inn - Effingham
Meeting facilities, handicap access, free breakfast, small pets allowed, indoor pool, bus parking, meeting services available, free movie rental.
Quality Inn & Suites
Located right off of Interstate 74 and within walking distance of the Market Place Mall, and just a block away from the Market Place Shopping Center.
Arvin Motel
Conveniently located on IL 33 in Robinson, with well-kept rooms featuring wall-mounted flat screen television. Very reasonable room rates. Handicap accessible facility.
Motel 6 - East Peoria
Motel located near all Peoria Area attractions and business. Affordable, clean comfortable rooms with WiFi available and complimentary morning coffee. Special rates and discounts available. Groups welcome. We'll leave the light on for you!
CITY:East Peoria
House of Blues Hotel
Opened 1998. 367-room eclectic hotel with design influences from Morocco, Thailand, and the Old South.
Days Inn - Farmer City
Make yourself at home at the Farmer City Days Inn. Business or pleasure you will be treated to all the standard Days Inn extras that make your stay more enjoyable, like our free Day Break Breakfast, refreshing SolTerre shower experience, free Wi-Fi in everyroom! Conveniently located between Champaign and Bloomington.
CITY:Farmer City
Fiesta Motel
Located on historic Route 66 in Pontiac, this 48 room motel offers free Wi-Fi and cable with HBO. Launderette facilities are available on site at this affordable motel.
Best Western Geneseo Inn
Conveniently located just minutes off of Interstate 80; near downtown Geneseo offering many shopping opportunities. Located only 20 minutes from the Quad City International Airport.
Best Budget Inn
A great locationin Joliet with Indoor pool and whirlpool.
Holiday Inn of Rockford
As Rockford's premier full-service hotel, the Holiday Inn of Rockford invites you to experience a hotel stay unlike any other. Whether you are traveling on business to see such companies as Daimler Chrysler, planning a day of shopping at CherryVale Mall or taking the family to Magic Waters, the Holiday Inn of Rockford is the first choice for travelers. The Hoffman House Restaurant, located inside the hotel is known for its world famous prime rib. The Scoreboard Lounge is one of Rockford's finest sports bars. For conventions, nothing compares. The banquet facilities can host from 5 to 500, complete with full service catering and technology needs. Relax, it's Holiday Inn, located right off I-90 on East State Street.
Aurora Fox Valley Inn
114 rooms, lounge, and restaurant. Laundry, large outdoor pool, and game room. Free continental breakfast.
Best Western Riverside - Danville
The Best Western Riverside Inn in Danville offers the best in service and hospitality. Enjoy the complimentary rotational breakfast bar featuring eggs, pancakes, french toast, french toast sticks, sausage or bacon (items vary by day). Additionally enjoy many of our savory baked items or variety Yoplait yogurt. All of our rooms are equipped with wireless high-speed Internet access, our exclusive Kohler luxury showerhead, plush beds, 250 thread count luxury linens, fluffy towels, 27 inch televisions with cable, in room coffee, in room hair dryers, and many more amenities to make your stay comfortable and convenient.
Hilton Lisle/Naperville
DuPage County, Chicago's Western Suburbs - 309 beautiful rooms, 23 versatile meeting rooms, two elegant ballrooms, business center, executive level, award-winning restaurant, bar, indoor pool, whirlpool and fitness center.
Prairie Winds Motel
The Prairie Winds Motel is conveniently located 1 mile west of Carthage, IL on US 136. Clean, comfortable, and affordable, the Prairie Winds Motel has free high speed internet, truck parking and weekly rates available.
DoubleTree by Hilton Chicago-Alsip
193 Rooms. Full service hotel located near Midway Airport in the Chicago Southland area.
Fulton Comfort Inn & Suites
This cozy hotel is one mile from the Mississippi River. Come experience the comforts of home in our spacious rooms and suites. Complimentary hot breakfast each morning, heated indoor pool and whirlpool spa.
Wingate By Wyndham Arlington Heights
Complimentary continental hot breakfast, free airport and local shuttle (Monday through Friday), whirlpool, exercise room, guest laundry, Jacuzzi suites, and meeting rooms available. High-speed wired and wireless Internet access throughout the hotel. 5 miles from Schaumburg Convention Center. Easy access to I-90. Minutes away from O'Hare Airport. Only 3 miles from Woodfield Mall. Complimentary Manager's Reception Monday through Thursday.
CITY:Arlington Heights
Super 8 Lodge South - Springfield
Newly renovated property with ample parking space. Right next to Interstates 55 & 72. Lots of restaurants nearby.
Royal Plaza Inn
40-year old, 2-story, interior and exterior doors, king size beds, full-size beds.
Hampton Inn
Oversize lobby with fireplace, beautiful, quiet location, expanded continental breakfast, pay per view movies. Free local calls, 800# access calls. 100% satisfaction guaranteed. Hilton Honors Bonus Program.
America's Best Value Inn
46-room motel across from Fort Massac State Park. Restaurants are within walking distance.
Galva Super 8
36 spacious smoking/non-smoking rooms available with 25" color TV, cable, refrigerator, and microwave in every room. Select from a standard king, standard double, handicap accessible and extended stay rooms. Complimentary hot continental breakfast, free local calls and wireless Internet access, fax & copy services. Located 6.55 miles from Historic Bishop Hill and .06 miles from the Wiley Museum.
Continental Motel
Spacious, quiet, clean and affordable lodging, with free in-room coffee, free continental breakfast. Enjoy 25" remote color tv-hbo and cable. Just minutes from I-57.
Gateway Inn Sullivan
Located nearby various attractions, including Eagle Creek and Wolf Creek State Parks and Lake Shelbyville, this facility is cozy and comfortable and is also pet friendly. Centrally located in the heart of fishing country.
L&M Motel
Located within two miles of the Mississippi River, the L&M Motel has been completely remodeled and features 32 theme rooms all with microwaves, refrigerators, courtesy coffee, phones, wireless internet, and air conditioning. We're very biker friendly and only 25 minutes from Galena!
Super 8 - Effingham
Suites available, small pets allowed, cable/movies, kitchenettes aveniable, in-room safe, free super start breakfast from 6:00 am - 10:00 am.
Motel 6 - Metropolis
52 room motel, offering an indoor pool and a continental breakfast
Hampton Inn & Suites - Effingham
Offers free breakfast, indoor pool & spa, free internet and parking, meeting rooms and suites are also available.
Quality Inn - Danville
Whether traveling for business or pleasure, the Quality Inn® hotel is the perfect place for lodging in the area. Discover the beauty Vermilion County holds, featuring everything from historic sites to nearly 15,000 acres of parks. This Danville hotel is conveniently located near several businesses, including McLane Midwest, Sygma, Alcoa and the AutoZone Distribution Center.
Abe Lincoln Motel
American family owned and operated for over 20 years. AM coffee and local calls free. Some kitchenettes available.
Hilton Garden Inn Rockford
Close to major businesses, sports centers and Interstate 90/39. Rooms have two speaker phones and large ergnomic work desk; complimentary USA Today on weekdays.

subset: commoncrawl


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The indiscriminate prosecution of Texas home school families ended with the Leeper case decision in 1994, which established that home schooling was indeed legal in Texas. However, school districts were left to their own devices as to how to decide whether families were truant or were actually home … [Read more...]
El Paso Home School Lawsuit to be Appealed to the Texas Supreme Court
A few weeks ago an El Paso appellate court ruled against a home school family in their civil suit against a local school district. Last month I posted a review and discussion of the El Paso ruling and how it impacts home schoolers. The family that filed that suit contacted me and asked that I … [Read more...]
THSC Saves Family Money
How did THSC save a family money? Insurance declared home school grades don't qualify for good student discount, THSC steps in and advocates for home schoolers. Keeping another Texas family free! Join today. Read Tim's letter to the Texas Department of Insurance. Read the original article and … [Read more...]
Judge Reprimands Family for Talking to Media, Confiscates Spectator's Cell Phone; Still No Ruling on Tutts' Right to Home School
The shenanigans taking place in the Tutts' fight to defend their family against CPS continue. On Friday, August 22, the Tutts were back in the courtroom for a hearing that was supposed to decide whether they would be allowed to home school their children. However, after taking testimony from both … [Read more...]
THSC Contacts Governor's Office in Response to Discriminatory Admissions Policies by State Colleges
When THSC became aware of state colleges that were adopting discriminatory admissions policies based on incorrect information, we sent a letter to the Governor's office asking them to help resolve the issue. Read Tim's letter. Read the response from the governor's office. … [Read more...]
Consider the Source; Stand with Gov. Perry
You have surely heard over the weekend or yesterday that the leftists in Austin have filed criminal felony charges against Gov. Rick Perry for threatening to veto part of the budget (something he is empowered to do as governor under the Texas Constitution) if the Travis County district attorney (who … [Read more...]
Judge will decide if Tutts can home school; Court refuses to turn over records
The decision about whether the Tutt family will be allowed to home school will be the topic of discussion when they return to court in Dallas County later this week. This decision for the four children now returned home has been reserved by Judge Callahan herself for this upcoming August 22 … [Read more...]
Effect of El Paso Case on Home Schoolers
Last week the 8th Court of Appeals of Texas issued a ruling about home schooling in a civil case filed by a home school family against El Paso ISD. This was in response to truancy charges that had been filed against them as a result of their family members alleging the children were not being taught … [Read more...]
Home Schoolers Sue Texas
THSC Association filed a lawsuit against the Texas Ethics Commission (TEC) in federal court in Lubbock on July 25. As a 501(c)(4), non-profit advocacy organization, THSC has focused since its founding on the mission of advocating for home schooling and parental rights. After the landmark Citizens … [Read more...]
Wallace Hall Won't Be Stampeded; Regent Committed to Doing What He Believes Is Right
The upcoming issue of Texas Monthly, which is now online, has an extended article regarding the controversy at the University of Texas at Austin and Regent Wallace Hall. It is an excellent article and gives great insight into Regent Hall and UT President Bill Powers. Perhaps more importantly for … [Read more...]
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Hey guys I just got a new Trails Illustrated Map # 782 for Cherokee and Pisgah National Forests French Broad & Nolichucky Rivers. Looks like about 80-90 miles worth of trails just North of Hotsprings , North Carolina and just South of Geenville, Tn in the Bald and Meadow Creek Mtns. Anyone ridden them? May be making a day trip up that way soon.
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I met Jenn at a Happy Herbivore meetup in San Diego. Upon meeting this
pretty gal, she shared some exciting news with me — she'd lost almost
50 pounds since adopting a plant-based diet and had radically improved her
life in other exciting ways (more on that soon!) I just knew I had to
parade her around on the Herbie of the Week series!
HH: Tell us a little bit about yourself and your health history:
I'm a 31-year-old ...
I asked my parents to reflect on their first year being plant-based.
Here's what my Dad had to say:
Where did a year go? It has been one year since my wife and I became plant-based. Ironically, the last piece of meat I had was in the hospital after having a mild heart attack and it was a dried-up piece of "Turkey Bacon." (Not my choice for a last omnivore supper.)
It's been an interesting ...
A few minutes later, as we were paying the check, my mom called my friend ...
After my father's post "What It Really Means to Feel Better," Daniel sent me an email detailing his journey to a plant-based diet. The results and changes were remarkable, so I asked him if he would be up for sharing his story as a Herbie of the Week. Luckily, he agreed!
HH: Tell us a little bit about yourself.
The day after my birthday, I received the most beautiful email from Brenda (I doubt she even knew it was my birthday). Brenda bravely shared her story with me -- the subject line of the email "It's time to tell you my story." I was moved to tears and asked Brenda if I could feature her, and share her email as part of our Herbie of the Week column. Lucky for us, Brenda said yes!
"Hi, LindsayI have ...


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CASCO, Maine — A driver who was involved in a crash that killed a 4-year-old in Maine last month is now missing.
WCSH-TV reports (http://on.wcsh6.com/1KvvW33 ) the Cumberland County Sheriff's Office confirmed Michael Minson was reported missing last Thursday.
Minson was driving in a car with 4-year-old Cameron Peterson and his mother on Aug. 11 in Casco.
The Portland Press Herald previously reported that Minson was running late for his job at Dunkin' Donuts in Naples when he lost control of the car and crashed into a utility pole. Cameron was thrown from the car in the crash and died on impact.
Minson and Peterson's mother were hospitalized with serious injuries.
Police are still investigating the crash.
Minson has been entered into the National Crime Information Center as a missing person.
Information from: WCSH-TV, http://www.wcsh6.com


text:
PREMIERES TUESDAY, AUGUST 11th at 10pmET/9pmC on HBO
By Ted Gioia
Long before Hard Knocks became a fixture of both reality television and sports cinema, late NFL … MORE ►
Posted: August 7th, 2015
PREMIERES TUESDAY, AUGUST 11th at 10pmET/9pmC on HBO
By Ted Gioia
Long before Hard Knocks became a fixture of both reality television and sports cinema, late NFL … MORE ►
Posted: November 26th, 2014
This week's episode of NFL Turning Point offers up a feast of quarterback duels and jaw-dropping receivers.
Ryan Tannehill and the Miami offense get off to a hot start, but Peyton Manning and … MORE ►
Posted: October 30th, 2014
"Ricky Williams – A Football Life" premieres Friday, October 31 at 9pm/ET on NFL Network.
Video by Jonathan Smyth
In telling the story of Ricky Williams' football life, it's impossible to overstate the importance of … MORE ►
Posted: October 28th, 2014
EDITOR'S NOTE: "Ricky Williams: A Football Life" premieres this Friday, October 31st at 9pm/ET on NFL Network.
By Paul Camarata, Producer
If the company he keeps truly can tell you much about a man, then … MORE ►
Tags: a football life, featured, ricky williams, sneak peek
Posted: September 30th, 2014
By Nick Calabrese
Starting in the 1960s, Steve Sabol established a habit of writing his thoughts down on 3″x 5″ index cards. His thoughts could include anything from poetry, commentary on coaches or players, even … MORE ►
Tags: baltimore colts, bill parcells, Chicago Bears, cincinnati bengals, cleveland browns, coach, coaches, dallas cowboys, detroit lions, don shula, featured, george halas, looking back, miami dolphins, mind of sabol, National Football League, new england patriots, new york giants, new york jets, nfl, paul brown, steve sabol
Posted: September 16th, 2014
This summer we had the chance to spend a lot of May, June, and July shooting with Brandon Marshall for our series "A Football Life." Marshall will be the only current player featured in the … MORE ►
Posted: September 15th, 2014
Friday September 19 at 9pm/ET on NFL Network, "A Football Life: Brandon Marshall" documents the powerful and at times painful journey of one of the league's best playmakers, who has turned his life around since … MORE ►
Tags: a football life, brandon marshall
Posted: October 30th, 2013
This week's episode of Turning Point kicks off with the Cowboys at the Lions. Heading into Sunday, this game featured two talented teams with high playoff aspirations. Dez Bryant finished the day with two scores, … MORE ►
Posted: September 25th, 2013
This week, our cameramen produced an embarrassment of riches in terms of top-notch football footage. This meant it was hard to wittle down all the great shots captured into just these five, but I think … MORE ►
Posted: April 23rd, 2013
NFL Films latest documentary, "Elway to Marino", airs tonight on ESPN at 8pmEST with a re-airing immediately following at 9:30EST. Director Ken Rodgers discusses the biggest challenge he faced while making the film.
In "Elway … MORE ►
Tags: 1983, 30 For 30, dan marino, espn, featured, john elway, nfl draft, premiere


text:
Dundurn National Historic Site
610 York Boulevard
Hamilton, Ontario L8R 3E7
The museum is only partially wheelchair accessible. Call for more details.
Dundurn Castle
Experience a guided tour of this 40-room Italianate-style villa built in the 1830's on Burlington Heights; the former site of a fortified military encampment established by the British in 1813. Once home to Sir Allan Napier MacNab, railway magnate, lawyer and Premier of the United Canadas (1854-1856) and his family, today Dundurn Castle tells the story of the family who lived above stairs and the servants who lived and worked below stairs to support their affluent lifestyle. Her Royal Highness The Duchess of Cornwall is the museum's Patron and the great, great, great granddaughter of Sir Allan MacNab.
The Kitchen Garden at Dundurn
Rich, bountiful, and a pleasure to the senses, the kitchen garden at Dundurn, as at any fine Victorian home, provided an abundance of fashionable fruit, flowers, vegetables, and herbs, essential to the kitchen and dining room. William Reid was Sir Allan's gardener for over 25 years. Explore his lovingly restored kitchen garden, where we use 1850's tools and varieties to grow food for Dundurn Castle's historic kitchen. Stop by the garden gate for the sights and scents of the 19th century.
Travel Canada's Garden Route to explore more gardens in Canada. This website contains the most comprehensive listing of Canadian gardens and garden experiences.
The Coach House at Dundurn
Housed in an 1870's Coach House, this unique, meeting and reception facility can accommodate groups up to 88 people. The Coach House is also home to The Castle Shop, featuring a variety of Canadian handmade crafts, souvenirs and special gifts.
The Hamilton Military Museum
The tranquil landscape around the Hamilton Military Museum known as Burlington Heights was a centre of defense from 1813 to 1815. This was home to men, women and children connected to the British army and First Nations allies who came together during the conflict known as the War of 1812. The new exhibit Blood Ties to a Gentle Landscape tells the stories of people who lived here by connecting artifacts, personalities and modern-day descendants. Step back in time and meet the people tied by blood to this gentle landscape.
Landscape Project
In 1855, Sir Allan Napier MacNab was the Premier of the combined Provinces of Canada and at the height of a very colourful career. He lived in Dundurn, the home he had built 23 years earlier with architect and landscape designer Robert Charles Wetherall and Master Gardener William Reid.
Dundurn National Historic Site is situated at the western end of Lake Ontario on a promontory referred to as Burlington Heights, a spectacular natural landscape. Wetherall and Reid sculpted the grounds into a picturesque landscape to complement the grand Italianate villa. Today, 150 years later, this is an historic site of national significance. It is however, also, a city park. The recent landscape restoration is being undertaken with respect for balance between these two aspects of the site.
The Museum is open year-round.
- Tuesday to Sunday, 12 noon to 4 pm. The last tour starts at 4 pm.
- Closed on Mondays, Good Friday, Christmas Day, Boxing Day and New Year's Day.
Depending on availability, we will open outside of regular hours for pre-booked groups.
- $11.50 for adults ages 18 to 59
- $9.50 for seniors ages 60 and above
- $9.50 for students ages 13 to 17. Students must show valid student ID
- $6 for children ages 6 to 12
- Infants who are five years old or younger visit for free
- $30 for a family of two adults and unlimited dependent children under 18 years old
Full-price ticket includes admission to Dundurn Castle, the Kitchen Garden and the Hamilton Military Museum.
Buy now and save 20%
Buy your tickets online to Dundurn Castle and save 20%!
We host a variety of events, workshops and exhibitions at Dundurn Castle throughout the year. No two trips are ever the same!
Month of Mourning
October will be a month of mourning at Dundurn. Costumed interpreters will lead visitors on a tour of over 40 rooms, many of which will be dressed for mourning. Experience the home in a unique way uncovering mourning customs and rituals developed during the Victorian period and get a glimpse into the personal experiences of the family through diary excerpts and newspaper articles and view some rarely seen artifacts.
- Thursday, October 1 to Saturday, October 31, 2015
- Time: 12 noon to 4 pm
- Ages: All
- Cost: Regular admission rates apply to the museum
Death and Dying at Dundurn
Elaborate mourning practices and rituals were developed during the Victorian period. The MacNab family was not spared these experiences which are well documented through newspaper articles, illustrations and journals when both Sir Allan MacNab and his wife Mary died at their family home. Other events surrounding Dundurn include hangings for treason, death from cholera, and the tragic Desjardins train accident of 1857. Join costumed Historical Interpreters for a special evening tour of the grounds and Castle to uncover the truths about these tragedies. NOTE: This tour contains outdoor components; please come dressed for the weather and for walking on uneven terrain.
- Saturday, October 31, 2015
- Time: 7 to 9 pm
- Ages: 14 years and older
- Cost: $30 per person. Pre-registration required.
We Remember
In honour of Remembrance Day, The Hamilton Military Museum presents a day of commemoration, on Saturday November 7 from 12 noon to 4 pm. The front lawn of Dundurn Castle will be the stage for a presentation by The Canadian Great War Society's Canadian Volunteer Cavalry Squad. Come and see Studio Babette's First World War puppet show, From Ruthven to Passchendaele. Paint a poppy in our First World War gallery and "plant" it in our Remembrance Day garden. While visiting the Military Museum, don't forget to dress up like a soldier and use your skills to identify our mystery military objects.
As always, The Hamilton Military Museum will be free to the public from Friday, November 6 to Sunday, November 8 for our weekend of Remembrance.
Victorian Christmas
Enjoy the beauty of a mid-19th century family Christmas celebration at Dundurn Castle. The Garden Club of Hamilton decorates the Castle in Victorian splendour with cedar boughs, ribbons and dried flowers. Bring your family and share a Hamilton holiday tradition.
- Sunday, November 22, 2015 to Sunday, January 3, 2016 (Closed Mondays)
- Time: 12 noon to 4 pm
- Ages: All
- Cost: Regular admission rates apply to the museum
First Day of Christmas
Visit Dundurn for the first day of its Victorian Christmas for FREE! Join costumed interpreters at Dundurn Castle for a free visit of the lavish home of Sir Allan MacNab and his family. The Castle will be decorated by The Garden Club of Hamilton with cedar boughs, ribbons and dried flowers. Bring your family and share a Hamilton holiday tradition. Please bring a non-perishable food item to help stock the Good Shepherd's pantry!
- Sunday, November 22, 2015
- Time: 12 noon to 4 pm
- Ages: All
- Cost: Free event
Victorian Christmas Delights
Enjoy an authentic Victorian Christmas cooking experience at Dundurn. Your culinary journey begins as you are greeted by costumed cooks who lead you below stairs to Dundurn's 19th century kitchen for a unique and entertaining experience preparing seasonal desserts! A tour of Dundurn decked out for the season is also included.
- Saturday, November 28, 2015
- Time: 9 am to 12 noon
- Ages: 14 years and older
- Cost: $50 per person. Pre-registration required
Family fun is on the menu! Come to Dundurn and prepare some tasty treats in the historic kitchen below stairs. While your treats are baking in the oven, costumed interpreters will guide you on a tour of the home. Complete your visit with a tasting of your delicious treats.
- Sunday, November 29, 2015
- Time: 9 am to 12 noon
- Ages: 6 years and older
- Cost: $55.00 for 1 adult and 1 child. $20 for each additional child. Pre-registration required
Christmas Evening Tours
Enjoy a unique opportunity to see Dundurn Castle decorated for Christmas in the evening. Begin your evening with carol-singing in the front hall, followed by an extended tour of Sir Allan MacNab's lavish home and a chance to sample an assortment of traditional Christmas foods served in Dundurn's historic kitchen.
- Weekends: December 4 to 6, December 11 to 13, December 18 to 20
- Time: 7 to 9 pm
- Ages: All
- Cost: $27 per person. Pre-registration required
Ring in the New Year
Enjoy a unique opportunity to see Dundurn Castle decorated for the holidays in the evening. Sir Allan MacNab was very proud of his Scottish Ancestry and celebrated the New Year surrounded by family and friends. Ring in the New Year at Dundurn with music, an extended tour of MacNab's lavish home and a chance to sample an assortment of traditional holiday foods served in the historic kitchen.
- Sunday, December 27, 2015
- Time: 7 to 9 pm
- Ages: All
- Cost: $27 per person. Pre-registration required
Historic Cooking Workshops
Bring together friends and family or colleagues and clients with a historic cooking program. Learn more about these workshops.
- Date modified:


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Town Square
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COMMENTS ON STORIESHow much does a City Council seat cost?
Former Councilwoman Kay Ayala and community activist John Carroll, both committed council watchers and frequent speakers,...Original post made on Oct. 19, 2012
Last comment by Angry, on Oct 30, 2012 at 6:52 am | 24 comments | 3103 Views
STATE, NATIONAL, INTERNATIONALObama's Rush to Judgment: Save Our Guns
There are so many problems in our society far worse than gun ownership, which is the foundation of our Constitutional freedoms....Original post made by Jennifer Wittingham on Jan. 16, 2013
Last comment by Cholo, on Jan 29, 2013 at 6:23 pm | 24 comments | 1344 Views
AROUND TOWN4 candidates in race to fill City Council seat in special May 7 election
The special election scheduled for May 7 to fill an empty seat on the Pleasanton City Council became a bit more interesting...Original post made on Feb. 11, 2013
Last comment by Janis, on Apr 2, 2013 at 3:52 pm | 24 comments | 3474 Views
AROUND TOWNPleasanton set to start negotiations tonight with employees union
The City Council will open negotiations with the Pleasanton City Employees Association (PCEA) at its meeting tonight in...Original post made on Feb. 19, 2013
Last comment by Ptown native, on Feb 21, 2013 at 5:37 pm | 24 comments | 4236 Views
SCHOOLS & KIDSSign the on-line petition if you believe PUSD should revert to the prior lice policy and communicate to parents in the class
See this KTVU news story http://www.ktvu.com/videos/news/pleasanton-school-district-starts-new-policy-for/vr46Y/ If you...Original post made by petition on Feb. 28, 2013
Last comment by Fact Checker, on Mar 6, 2013 at 11:22 pm | 24 comments | 1789 Views
AROUND TOWNMercedes dealership
What's up with the Mercedes dealership. Appears to be empty. Are they closed? At one time I heard they were building a new...Original post made by Earl on Mar. 18, 2013
Last comment by Leo , on Mar 23, 2013 at 3:37 pm | 24 comments | 2193 Views
SCHOOLS & KIDSdoes someone know why the PTSA says this?
I just learned that the graduation ceremony from AVHS used to be held at the fairgrounds, with only 3 tickets per students....Original post made by Resident on Jun. 12, 2013
Last comment by Alice, on Aug 6, 2013 at 9:39 pm | 24 comments | 2505 Views
SCHOOLS & KIDSPleasanton Parent Priorities
Over the last month I have read about local Pleasanton students vandalizing a school library, Senior cut day and finally...Original post made by Dawn on Jun. 18, 2013
Last comment by Parent, on Jun 26, 2013 at 3:32 pm | 24 comments | 2499 Views
AROUND TOWNPleasanton Council OKs high density apartment complex on Bernal at Stanley
With only one objector at a two-hour public hearing, the Pleasanton City Council Tuesday approved construction of a 345-unit...Original post made on Aug. 8, 2013
Last comment by XYZ, on Aug 12, 2013 at 3:45 pm | 24 comments | 3004 Views
AROUND TOWNHomeless on Valley Ave
Today I noticed a homeless man near the corner of Valley and Santa Rita - Safeway side, by the gas station. He had a cardboard...Original post made by Curious on Sep. 1, 2013
Last comment by franco, on Sep 3, 2013 at 8:31 pm | 24 comments | 1497 Views
AROUND TOWNWith just 3 days to go, BART-unions say they're making progress to avert Friday morning strike
With three days remaining before a 60-day cooling off period expires, negotiators for BART management and its labor unions...Original post made on Oct. 4, 2013
Last comment by Kathleen Ruegsegger, on Oct 7, 2013 at 6:21 am | 24 comments | 2365 Views
SCHOOLS & KIDSPleasanton school board to consider longer school year at its meeting tonight
The Pleasanton school board tonight will consider extending the school year, possibly beginning classes in mid-August or...Original post made on Oct. 8, 2013
Last comment by Cholo, on Oct 11, 2013 at 1:28 pm | 24 comments | 5456 Views
AROUND TOWNStoneridge Drive, Stoneridge Creek open today
City, civic and business and regional leaders from Pleasanton, Dublin, Livermore and Alameda County will cut a ribbon at...Original post made on Nov. 1, 2013
Last comment by El Loco, on Nov 4, 2013 at 8:55 pm | 24 comments | 20315 Views
AROUND TOWNIt's flashing yellow, can I turn?
The city of Pleasanton has changed the traffic light at Hopyard Road and Parkside Drive to a four-phase signal that motorists...Original post made on Dec. 23, 2013
Last comment by Gail, on Dec 30, 2013 at 7:36 pm | 24 comments | 7901 Views
AROUND TOWN'New' Stoneridge Drive now 40 mph
The speed limit on the newly extended section of Stoneridge Drive has been raised to 40 mph despite objections from City...Original post made on Jan. 16, 2014
Last comment by Cluelessness, on Jan 26, 2014 at 11:45 pm | 24 comments | 7762 Views
AROUND TOWNHacienda Housing Park or China Town
Hacienda Business Park is the biggest mistake in Pleasanton history. All we can do now is build housing and schools. They...Original post made by Jim on Feb. 1, 2014
Last comment by Cholo, on Feb 5, 2014 at 5:25 pm | 24 comments | 1253 Views
AROUND TOWNThings I Love in Pleasanton
The Beautiful day we're having, The Dairy, The Farmers Market. Out cultural diversity, Numerous beautiful parks and...Original post made by Love, too on Mar. 18, 2014
Last comment by On the Road, on Jun 12, 2014 at 7:32 pm | 24 comments | 2225 Views
SCHOOLS & KIDSSchool board set to discuss new possible calendar options
The Pleasanton school board will meet Tuesday night to hear a report on the non-traditional calendar for the 2015-16 school...Original post made on May. 24, 2014
Last comment by Jtjh, on May 28, 2014 at 1:38 pm | 24 comments | 4157 Views
AROUND TOWNCouncil votes to move forward on East Side development planning
Following through on their campaign pledges, newly-elected and re-elected members of the Pleasanton City Council voted last...Original post made on Dec. 17, 2014
Last comment by To Bill, on Dec 22, 2014 at 10:25 pm | 24 comments | 5084 Views
AROUND TOWNSchool board approves 2015-16 calendar
The Pleasanton school board approved the dates for the 2015-16 instructional calendar Tuesday evening, with a start date...Original post made on Feb. 25, 2015
Last comment by caywen, on Mar 2, 2015 at 7:11 am | 24 comments | 5157 Views
Editorial: Pleasanton Police Department's unwarranted silence unacceptable
By Gina Channell-Allen | 17 comments | 1,327 views
Doubling Dublin
By Tim Hunt | 2 comments | 605 views
The Cleric and the clerk*
By Tom Cushing | 12 comments | 463 views
The Arts and Critical Thinking
By Roz Rogoff | 7 comments | 332 views


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Pro Bowlers Leave the Kansas City Chiefs Hours Into Free Agency
Pro Bowlers Dexter McCluster and Brandon Albert will not be with the Chiefs in 2014, along with fellow starters Geoff Schwartz and Tyson Jackson.
Pro Bowlers Dexter McCluster and Brandon Albert will not be with the Chiefs in 2014, along with fellow starters Geoff Schwartz and Tyson Jackson.
I just moved to Sedalia fairly recently. When I first found out I was coming here, I decided I should find out the details of the town. So of course, I looked up stuff like restaurants, shopping, the local gym and things like that. Another thing I looked up was the history, landmarks and other interesting facts about Sedalia. Turns out there's actually quite a few interesting things about Sedalia!
Well we definitely got our fair share of snow here in Missouri. If you're like me and drive a little car, you probably hate it. But I remember a time when I actually used to love the snow. When you're a kid, it's great! There's tons of fun stuff to do. But what was the absolute BEST thing about snow when you're a kid?
Everyone is probably familiar with Time Magazine's annual "Person of the Year" issue. It features a person or group that for better or for worse has done the most to influence the events of the year. Right now in a poll Miley Cyrus is actually leading the vote.
A while ago I asked who do you think should be the Time Person of the Year, which gave me a better idea: who do you think should be the Sedalia Person of the Year?
On Tuesday night (Nov 26), I was lucky enough to participate in the Child Safe Dessert Auction at the Celebration Center in Sedalia. It was a great event that raised over $5,000 for the Child Safe program of Central Missouri.
On Tuesday morning (Nov. 19), Missouri Governor Jay Nixon and Senator Roy Blunt spoke to a large crowd in the Mathewson Center on the Missouri State Fairgrounds during a celebration of MFA's 100th anniversary.
Justin Moore urged his fans to stand up, then he fell down during the opening night of his Off the Beaten Path Tour in Springfield, Mo. over the weekend. In fact, he fell twice!
LEE'S SUMMIT, Mo. – If you were to pick the Missouri city where you are most likely to strike a deer with your car, would you pick Kansas City? Maybe Lee's Summit? They ranked first and second in 2011 for deer-vehicle collisions in Missouri.
My girlfriend Jami is coming down from Michigan to visit me for a week. To say that I'm incredibly excited about this would be an understatement. She'll be here from Oct. 16-23, but I want to get a jump on planning stuff ahead of time.
I already have a few things planned. We'll be going to the Kansas City Chiefs game against the Houston Texans that Sunday. We also plan on going to the Kansas City Zoo and having a bar night at Dukes and Boots. But I need some more ideas!


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Danielle Jennette, a swimmer at Kings Fork High School in Suffolk, Va., has asked Olympic gold medalist Ryan Lochte to be her prom date...
Danielle Jennette, a swimmer at Kings Fork High School in Suffolk, Va., has asked Olympic gold medalist Ryan Lochte to be her prom date, but no answer yet.
If he says yes, here's betting they carpool.
NFL headlines
• At SportsPickle.com: "Adrian Peterson falls 903 yards short of 3,000."
- Roads could be a mess this weekend — and Monday
- Seven things to know about Seahawks rookie Tyler Lockett
- New GM Jerry Dipoto provides more insight into how he'll turn Mariners around
- Jammed-up I-405 forcing some buses to the shoulder
- Parents of toddler killed in Bellevue to return to India
Most Read Stories
• At Fark.com: "Much like Jay Cutler, Lovie Smith has been sacked."
Tag-team teachers
Twin sisters Lucy and Kelly Knott, 24, of Stockport, England, are teaching assistants by day and pro rasslers by night.
Classroom discipline probably isn't a problem.
Hooked that one
NASA's Kepler Telescope discovered two mysterious objects more than 65,000 light years from Earth.
Alas, just a couple of Gerald Ford's errant tee shots.
Not bowled over
"This season's bloated roster of 70 bowl-ing schools includes 15 teams with five losses, 14 with six losses and two — Georgia Tech and Duke — with seven," noted Greg Cote of the Miami Herald. "(New rule: If Duke is in a bowl, there is one too many bowl games.)
"The math, therefore, says that 31 of 70 bowl teams, almost half, had seasons that would get the coach's house egged in any self-respecting college town."
Double digits
Philadelphia's Andy Reid was among seven NFL coaches fired Monday, and the locals seem to approve his departure.
At least, all the hardcore Eagles fans gave it two fingers up.
Quote marks
• Florida football coach Will Muschamp, to the Orlando Sentinel, on the importance of making his team bigger and tougher: "You don't pay money to see the featherweights. You pay to see the heavyweights."
• Packers QB Aaron Rodgers, to TSN, on why teammate Jeff Saturday is the perfect center: "Low sweat ratio and solid butt height."
• Comedy writer Alan Ray, after the 2-14 Jacksonville Jaguars fired GM Gene Smith: "To make sure the players were nowhere to be found, the announcement took place in the end zone."
• Ole Miss QB recruit Devante Kincade of Dallas, to USA Today, on what it feels like to throw an interception: "Think about how embarrassing it would be to get your girlfriend taken."
Or Chuck Roast
Enterprising restaurateurs in Philadelphia, no doubt, are pushing for Jon Gruden to be the next Eagles coach.
Chucky Cheesesteaks, anyone?
Dwight Perry: 206-464-8250 or email@example.com


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Hyper Lode Runner
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We are looking for nurses to work 12pm-12am, and 7pm-7am. Also open to per diem!
We are currently recruiting for Nursing Assistants!
Coordinate total nursing care for patients, participate in patient and family teaching, and provide leadership by working cooperatively with ancillary nursing and other members of the interdisciplinary team to achieve optimal clinical and resource outcome


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SF Pride Sued Over Shooting
A man who was shot at last year's San Francisco Pride celebration is suing organizers, claiming they were negligent because they failed to provide adequate security.
Trevor Gardner, 24, is suing the LGBT Pride Celebration Committee for "not less than $10 million," according to the complaint he filed May 29 in San Francisco Superior Court.
Gardner, who lived in Los Angeles at the time of last year's festival, worked as a model for Tropicana Las Vegas Inc. at its booth June 30 near Civic Center and was taking down the stand when "an altercation broke out in the crowd," the filing says.
"There was an utter lack of security personnel to address the altercation," or take other steps, according to the complaint. After the fight "escalated, unabated," one man fried a gun into the crowd.
Gardner was shot in the leg and his femur was shattered.
"He was left bleeding on the ground" and "with no security present, the shooter was able to nonchalantly exit" the event "and disappear into the abyss of the city," the court document says.
While bystanders took videos on their phones, nobody from the Pride Committee attended to Gardner, who was "bleeding to near death," according to the complaint. Another man was also shot in the incident.
Gardner's co-worker and someone from another booth came to Gardner's aid.
Among other problems, he "remained immobile and unable to care for himself for months" and "will have to endure pain resulting from this incident for the rest of his life," Gardner's filing says.
"A partial bullet" remains in his leg, and Gardner "will need to endure lifelong medical care" and "has lost wages and lost earning potential," along with other impacts, according to the court document.
George Ridgely, the Pride Committee's executive director, and board President Gary Virginia declined to comment on the lawsuit, citing its pending nature. Both men joined the Pride organization months after Gardner was shot. Pride officials haven't filed a formal response, according to the San Francisco Superior Court's website.
The complaint points to several factors that Gardner feels should have made clear to Pride organizers that they needed to do more to ensure safety for people attending the parade and celebration.
"Notwithstanding the numerous SF Pride and Halloween shootings and stabbings that have transformed the event into a virtual shooting gallery in the high crime Tenderloin," where much of the festival takes place, the committee "failed to secure the perimeter of the event in 2013, allowed individuals to enter the event with little or no security screenings, and failed to maintain an adequate security presence at the event."


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Distracted By The Sexy: Western Animation
- In the Batman: The Brave and the Bold episode "Night of the Huntress!", Blue Beetle is distracted by Huntress's sex appeal instead of having his head in the game during the fights:
Blue Beetle: I'm sorry! Your hotness distracted me!!
- Gadget used this in an episode of Chip 'n Dale Rescue Rangers to cause a thug who was controlling a tank with a neural interface helmet to lose control and allow them to escape the villains death trap.
- When Paulina on Danny Phantom was first introduced, they showed all sorts guys reacting to her like this. Oddly enough, that's the only time they did.
- At one point in Dexter's Laboratory, Dexter gets so fed up with Dee Dee, he holds interviews to get a replacement. He winds up hiring a vixen who he can't do any work around.
- In the Disney ClassicTM Ben and Me — the story of how Benjamin Franklin owes all his inventions and wisdom to a mouse — ol' lecherous Ben is ogling a young woman when the mouse yells out "Post, Ben! Post!" leading Ben to comment "Well, how do you do, Mr. Post?" shortly before smacking face-first into said post.
- Truth in Television; Mr. Franklin had an eye for the ladies.
- Happen in Welsh Stopmotion show Fireman Sam when Trevor Evans crashes a bus in "Dilys's Forgetful Day", when he drives past Penny, the new girl in the Ponypandy fire service.
- Futurama
- This is done mostly every time Amy Wong is wearing less than usual.
- In Bender's Game, during the parody of The Lord of the Rings, one orc-thing climbing a ladder while assaulting the castle catch sight of Amy taking off her top through a window. Cue abundant drooling, which happens to be acidic and burns through the ladder's steps, sending him falling.
- Peter Potamus in Harvey Birdman, Attorney at Law almost screws up his defense of Birdman when the stenographer's blouse buttons start to pop off.
- Invoked by Mickey Mouse in the House of Mouse episode "Clarabelle's Big Secret" when he attempts to prevent Clarabelle Cow from revealing the secret by distracting her with Horace Horsecollar, who is in his underwear while striking a manly pose.
- Believe it or not, Mr. Bogus, of all people, actually falls victim to this in the episode "Bogus Private Eye", with a female rat who enters his office to tell him about the crime organization that had arisen in the city.
- My Little Pony: Friendship Is Magic: In "Rainbow Falls", Soarin' smacks into an obstacle and crashes when he sees two cheerleaders while he was flying.
- In the Phineas and Ferb episode "I Scream, You Scream", Ferb's initial encounter with his Precocious Crush, Vanessa, leads to him taking the plans she was picking up and vice-versa.
Phineas: Hey Ferb, snap out of it! What happened back there?
Ferb: ...I was weak.
- Regular Show has four instances of Mordecai reacting to seeing Margaret in various outfits and slightly sexual situations:
- "Caffeinated Concert Tickets" gives us him immadiately cutting off his sentence and drooling when he sees Margaret in a shirt which shows some generous Sideboob.
- "Mordecai and the Rigbys" has him gawking with his mouth gaping open and dropping the box he was holding when Margaret puts on one of his band's shirts (a bit hard to explain, here's a clip. Unfortunately it's in Spanish as all the English versions get removed).
- "Slam Dunk" features a scene in which he stares at Margaret as she passes him on her bike, followed by a detailed shot of her butt.
- In "Do or Diaper", Mordecai freezes for a moment and stares at Margaret in a fancy dress after she opens her apartment's door when he comes to pick her up.
- In Spider-Man and His Amazing Friends, when Peter Parker first meets Angelica Jones (whilst walking Ms. Lion), he has this reaction:
Angelica: (referring to Ms. Lion) Well, somebody's found a friend.
Peter: You can say that again!
Angelica: Her name is Ms. Lion. I'm Angelica.
Peter: You sure are... I'm Peter Piper... Uh, P-Parker... Uh, Parker Peter—
- Hilariously used during an episode of The Boondocks, when Tom draws the attention of a prison inmate.
- The Mask has a perfect example of this (though it can also count as Show Some Leg, depending on how you look at it) in the episode "Flight as a Feather". After stripping two suicide belts off an exotic dancer named Cookie BaBoom (who crashed a ceremony held by the Mayor), The Mask sees Kellaway and Doyle coming to get him. The Mask then gets behind Cookie (who has been trapped in her own whirling dervish) and stops her so that way the front part of her naked body faces Kellaway and Doyle. The Mask escapes, Kellaway and Doyle melt like a Hershey's kiss on a hot skillet, and the Mayor smiles as he basks in the glow of his ex-girlfriend's humiliation. And this was all on a CHILDREN'S show (albeit one from the 1990s, when this kind of shock humor was in vogue).
- Large zig-zag: On The Powerpuff Girls in the debut episode of the Rowdyruff Boys, the seemingly defeated girls get some advice from Ms. Bellum in turning the tide. The girls completely disarm the boys with long, come-hither eyelashes, then they make the boys explode by kissing them.
- Thundercats 2011
Panthro: Close that mouth, you're drooling.
- In "Omens Part One", the first time Lion-O meets his Body Guard Crush Cheetara his voice cracks. Lion-O later feigns this, using the sight of two passing women to avoid mentioning a vision he saw in the Sword of Omens.
- In "Journey to the Tower of Omens" Lion-O, trying to master Sight Beyond Sight and failing, gets flustered when Cheetara tries a Hands-On Approach, taking him by the shoulders and telling him to relax.
- In the same episode, Tygra openly gapes at the sight of Cheetara using her Super Speed, which Panthro lampshades with a smirk and a chiding:
- Total Drama Island
- Inverted by the girls (and Owen) who go into a frozen gaze whenever Justin is in sight.
- Played straight when Heather's top is ripped off and it distracts Harold during one of the challenges.
- Happens during Blackarachnia's first appearance in Transformers Animated. As soon as it is revealed that the giant, scary-looking alien spider is a giant, sexy-looking alien robot, Bulkhead and Bumblebee (who have apparently never seen a female of their species before) immediately drop their guard, which allows her to take them out.
- Six from Tripping the Rift. Practically anything she does will make a guy's jaw hit the floor.
- In an episode of X-Men: Evolution, the X-Men are repairing their mansion. Scott Summers and Jean Grey distract each other. Jean almost smacks Storm with a statue she was levitating. Logan angrily orders Scott to pay attention.


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Hotel Gambrinus
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Montisi and Hot air ballooning
One of the highlights of the trip so far was our morning ballooning with Chris and Claire from "Ballooning in Tuscany". We had an early start (5am) to be down at the launch field for 5.40am and then we took off at about 6.30-6.45am on a beautifully sunny morning with fantastic views over the Tuscan countryside - the pictures hopefully do it more justice than any description I can ...
I Want to go Back to Orvieto
... the piazza in front of the massive Cathedral with its ornate facade. A gentleman in the town hall across from it struck up a conversation with us and said it took 12 generations of builders to complete the structure. The town had a nice semi urban vibe to it and I noticed it is on the main train line between Florence and Rome. Easy to revisit without a car. :-)
A Town Worthy of a Visit
... building so we weren't sure where the old town was from there. We walked along past a post office and down a main road, turned a corner and there was this spectacular view of the bluff and the old town in front of us....breathtaking! ...
I want to be alone !!
... is not officially on La Via Francigena. It used to be the main pilgrim routeroute to Rome up until the end of the 12th Century when it became safer for them to go via Radiocofani, one of the stages of Archbishop Sigeric's documented route. I expect to get a bit of stick for straying 'off-route', but it is only a matter of time - to sort out 'rights of way' issues - before my way is designated an official variant of the VF route.
Today would have ...
Under the Tuscan Sun
... quartered and saut�ed with garlic and rosemary and the whole lot deglazed with a little white wine.
We ate dinner at a great little restaurant on Saturday night, taking two escalators to get to the right entrance of Cortona after parking our car. The weather was a little unpredictable so we relinquished our table on the terrace for one inside the old, low vaulted brick room. Here we feasted on a first course of local fresh ...


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Make it easier for your cat or dog to get on the bed, couch and other challenging places with the Easy Step IV pet stair from Pet Gear. The 4 wide, deep steps give little dogs and cats enough room to fit their entire body on each platform before taking the next step. Large dogs can comfortably climb them too. Each step is slightly inclined, so your dog or cat has fewer stairs to climb.
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other Info.
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To obtain a copy of the manufacturer's warranty for this item, please call Target Guest Services at 1-800-591-3869.
- Online Item #: 14306996
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Judge rules differently on the exact same facts. From the Daytona Beach New Journal.
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Oldham County Ordinances / Frequently Cited KRS
Alarm Ordinance
Alcoholic Beverage Ordinance
Animal Control Ordinance
Nuisance Ordinance
Peddler's Ordinance
Restaurant Smoking Ordinance
Social Host (Keg) Ordinance
Event Ordinance
Kentucky Driving and Cell Phone Laws
Kentucky House Bill 415 has been signed into law on April 25th, 2010.Under the new driving law, drivers under the age of 18 will be prohibited from using a cell phone while driving. Specifically:
"Any person under the age of eighteen (18) who has been issued an instruction permit, intermediate license, or operator's license shall not operate a motor vehicle, motorcycle, or moped that is in motion on the traveled portion of a roadway while using a personal communication device, except to summon medical help or a law enforcement or public safety agency in an emergency situation."
Text Messaging while operating a motor vehicle will be prohibited for all drivers. Specifically:
"No person shall, while operating a motor vehicle that is in motion on the traveled portion of a roadway, write, send, or read text-based communication using a personal communication device to manually communicate with any person using text-based communication, including but not limited to communications referred to as a text message, instant message, or electronic mail."
The Fine for a first offense will be $25 and subsequent offenses will cost $50 plus court costs.
There are exceptions for emergency situations in the case of cell phone use for drivers under the age of 18 and text messaging.
To review the law, please go to House Bill 415.
Occupant Protection - Seat Belt
Effective July 12, 2006, Kentucky's seat belt law became a "primary" or standard enforcement law. This means that law enforcement officers can now stop a vehicle solely for an occupant restraint violation. Previously, Kentucky's law only allowed officers to cite for this violation if some other violation initiated the traffic stop.
The new law resulted from House Bill 117, passed during the Kentucky General Assembly's 2006 regular legislative session.
In summary, Kentucky's seat belt law specifies the following: