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Flexible Flashlight with Magnetic Pickup
- Item#:
- ampro-t73585
- Our Price:
- $17.29
- Flexible Magnetic Shaft reaches narrow, confined spaces
- Magnetic Tip
- Requires Two (2) AA Batteries (not included)
The AmPro Flexible Flashlight with Magnetic Pickup features a flexible shaft that reaches into confined and closed spaces and it features a magnetic tip for picking up metal objects.
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Within 30 days of receipt of your order, you may return any unused tool in its original condition, in its original packaging for a full refund. In addition, certain manufacturers allow for returns under their "Satisfaction Guarantees" and we honor the terms of these manufacturer return policies.
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News & Information
- 09/30/2015 Learn More about Handling Gas & Electrical Hazards at a Free Workshop on 10/27 at 7PM Learn more about the importance and response for gas and electrical hazards during a disaster at our free Tri-Annual Training on October 27, 2015 at 7PM in San Leandro at the Marina Community Center. Please click on the link above for more information.
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Have a look at last year's 2014 sponsored ride! Looks Brilliant!
Charity Sponsored Ride, in aid of:
Parkinson UK
Dogs For The Disabled
Oxfordshire Air Ambulance
Bicester & Whaddon Chase Hound Club
Sunday September 27th 2015
By kind permission of Mr & Mrs J Budgett, Mr & Mrs J Tylor & Mr and Mrs J Nicholson A ride across 7 miles of beautiful rolling private parkland with old turf so the going is always excellent. You will ride across grass, woods and tracks, no roadwork. Seven miles with 50 fences plus bonus fences including water – jump all, some or none at all. New fences & re vamped course for 2015. The jumps are inviting, some more challenging than others and all avoidable for those who prefer not to jump.
There are Generous prizes to be won
Closing date is September 24. Late entries may be accepted, with a surcharge BUT we are always oversubscribed and have to turn people away so please enter as soon as possible. Proceeds to: Parkinson UK Dogs For The Disabled Oxfordshire Air Ambulance Bicester & Whaddon Chase Hound Club


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Zoo Med Repti Basking Spot Lamp with UVA
|Zoo Med Reptile Basking Spot Lamp is a unique patented double reflector focuses 35% more heat and light into a tight beam. Perfect for use with high heat basking reptiles, such as tropical and desert species. Unique patented double reflector focuses 35% more heat and light Tighter beam creates a more effective basking site than other reflector bulbs Perfect for use with high heat basking reptiles Zoo Med Reptile Basking Spot Lamp provides beneficial UVA rays which promote stuff like breeding, feeding and are beneficial to your reptile's psychological well-being. Increases the overall ambient air temperature, necessary for the proper health of all reptiles and amphibians. Creates the proper heat gradients necessary for thermoregulation. Perfect for use in Zoo Med's "vertically mounted" Slider Hood!3 month manufacturer warranty.FAQ:Q: How can I get the maximum out of a lamp?A: Minimizing handling: lamps that get moved or vibrated burn out quickly. Make sure that the fixture isnt being moved regularly. It is best to use a quality ceramic socket, not a plastic socket. You can check your fixture by unplugging it and looking at the metal tab in the center - where the bulb screws in. This tab can be pulled slightly forward to ensure that it makes a good contact with the bulb.Q: Does this lamp emit UVB?A: These lamps are primarily a heat source. They generate UVA but not UVB.Q: Does this lamp emit UVA?A: Yes. This lamp provides beneficial UVA rays which promote breeding and feeding and are beneficial to your reptiles well being.Q: How long should I leave this lamp on each day?A: This lamp should be on for 10 - 12 hours a day to maintain your animals day and night cycle.
Zilla Night Black Heat Incandescent Bulb for Reptiles
|Zilla Night Black Light Incandescent Bulb is ideal for tropical and desert habitats, the Night Black Light Incandescent Bulb provides ambient heat in which the photons emitted by the filament never escape the dark tint. Provides ambient heat in terrariums Great for night-time viewing to observe natural nocturnal behaviors Provides a 24-hour ambient heat source for a healthy reptile environment The Night Black Light heats the air inside the enclosure to create the warmth needed for a healthy reptile environment. The bulb is coated with rare earth black phosphors, which simulates the moon's natural glow for nocturnal viewing without disturbing the reptile's day/night cycle.
Zoo Med Reptisun T5 HO High Output Terrarium Hood
|Zoo Med's ReptiSun HO T5 Terrarium Hoods are designed to provide your pet reptiles with the UVB and UVA they need in an efficient, long-lasting lamp. High Output (HO) T5 fluorescent lamps provide UVB penetration at greater distances, making these hoods an ideal choice for taller terrarium tanks and cages. Limited Time Only - Includes FREE ReptiSun T5 HO 5.0 UVB Lamp New low profile design is only 1" tall with a highly polished curved reflector for increased lamp efficiency Energy efficient T5 HO electronic ballast for rapid start and maximum llight & UVB output The included T5 HO lamp is the strongest ReptiSun lamp available, is 2 times stronger than T8 fluorescent lamps, and provides UVB, UVA and visible light for your reptile. The lighting hood features a low profile design and uses an energy efficient T5 HO electronic ballast for rapid startup and maximum lamp performance. A highly polished curved reflector increases the lamp's efficiency.Why is UVB important?Reptiles need UVB for Vitamin D production and calcium metabolism. Without UVB, reptiles can develop Metabolic Bone Disease in 6 months or less. UVB, along with proper temperatures, will enable your reptiles to make Vitamin D and process calcium from their diet.Why is UVA important?Reptiles and amphibians can see things that humans can't. UVA is part of the rainbow of colors that reptiles can see. UVA helps to increase animal activity levels, appetite, and reproductive behaviors. Without UVA, they are color blind!The ReptiSun HO T5 Terrarium Hood is for use with the following lamps:Reptisun 5.0 HO - 15 watt / 12" (Item FS5-15) Designed for use with tropical & temperate reptiles For terrariums up to 18" tall ReptiSun 10.0 T5 HO - 15 watt / 12" (Item OS5-15) Designed for use with desert reptiles For terrariums up to 30" tall Always follow all safety instructions when setting up and operating your terrarium light hood.1-year manufacturer's warranty.


text: More from SI Report: Dodgers release pitcher Freddy Garcia Report: Dodgers release pitcher Freddy Garcia Marshawn Lynch sports gold cleats for Super Bowl Marshawn Lynch sports gold cleats for Super Bowl Louisville vs. FIU: Game time, live stream, TV coverage Louisville vs. FIU: Game time, live stream, TV coverage Pittsburgh-area high school football player dies after... Pittsburgh-area high school football player dies after... Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Floyd Mayweather Jr. expresses interest in buying Clippers by Scooby Axson Email Posted: Tue Apr. 29, 2014 Updated: Thu Jun. 12, 2014 Welterweight boxing champion Floyd Mayweather Jr. attends a Clippers game in February. (Noel Vasquez/GC Images)WBC welterweight champion Floyd Mayweather, Jr. said he is interested in buying the Los Angeles Clippers and has spoken to his advisers about making a bid to buy the team. Mayweather is a regular at Clippers games and said he would stop gambling on sports games if he were to become a co-owner of the team.He said he had no issues with current owner Donald Sterling during the times they interacted."I called Al today about that to see if me, Leonard and Al, and hopefully Richard and a couple of other guys, a couple other of my billionaire guys, we can come together and see what we can come up with," Mayweather said, via ESPN.com. "Hopefully, we can do it, and it's not just talk."With me, I can't come in talking about Mayweather only gonna get 3 percent, 4 percent. I got to get a solid percentage. Do we want to buy the Clippers? Yes, we do. We are very, very interested in buying the Clippers. We'll keep the Clippers right where they're at. When I'm not boxing, I'm at the games all the time. We do want to buy the Clippers. Me and my team do want to buy the Clippers and we can afford the Clippers."Mayweather, 37, (45-0, 26 KOs) has other pressing matters to attend to as he is set to fight Marcos Maidana (35-3, 31 KOs) in a unification fight on Saturday. McCANN: Sterling, NBA set for epic legal fight over Clippers Promoted Stories Comments


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The Vampire Diaries Spoilers
What is on tap for The Vampire Diaries Season 5? We have our first idea, thanks to producer Julie Plec.
Posted in: Vampire Diaries
The Vampire Diaries Spoilers: Who's Coming Back?
A key character is returning to The Vampire Diaries... in some capacity. Read on for more!
The Vampire Diaries Spoiler Pics: Welcome to New Orleans
The Vampire Diaries takes a trip to New Orleans on April 25. Head down there yourself now via these photos from "The Originals."
The Originals Description: Big Trouble in The Big Easy
What can you expect from The Originals? The CW has released the official Vampire Diaries episode synopsis for this installment.
Marcel on The Originals: First Look!
Entertainment Weekly has your first look at Marcel and The Originals. Check out this photo now!
Mystic Falls Prom Pictures: Fashion and Flasks!
Ready for the Vampire Diaries prom? Sort through these photos now from "Pictures of You."
The Vampire Diaries Prom: You're Invited!
The Vampire Diaries will go to the prom on April 18! Read the official synopsis now for "Pictures of You."
The Vampire Diaries Picture Preview: Scared and Shirtless
The Vampire Diaries airs "American Gothic" on March 28. Check out photos from the episode now!


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Spectacular Japanese Awaji ware piece in shades of blues, violets, and brown. It is absolutely gorgeous and extremely unusual. Fully marked on the bottom of the piece. It measures approximately 5" tall. It has no chips or cracks.The marks on the bottom, the Sanpei flag and Japan, and the architectural styling date it between 1910 - 1922. This mark as used between 1890 and 1922.
Divine Treasures from All Parts of the World - Now Accepting Credit Cards Through Ruby Lane Checkout
Welcome to my shop, I have just returned from a shopping trip and will be adding lots of new items!


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21 inch Axle Strap with Sleeve and 2 D-Rings
SCCA Off Decal for Master Switch
SCCA Red E Decal for Fire Extinguisher
AMB/MyLaps Tran X 260 Direct Powered Transponder
Ring Terminals for 6 Gauge Battery Cable
"Great parts and people. I have had no problems with anything I have ever bought from Pegasus. I will be buying more from Pegasus." D.B. from Alabama
Brand: Mylaps Sports Timing
MX is for Motocross
The AMB MX Personal Transponder is designed for use in Motocross, Snocross, and Enduro (off-road) motorcycling and snowmobiling applications. Bright orange color makes it easier to find in mud or snow if it should fall off.
The rechargeable unit mounts to a quick-release bracket (included) and should be mounted to the front fork between 2 feet and 4 feet from the ground. A full 16 hour charge on the included 115VAC/12VDC charger will give 4 days of run time.
Note: The MX is NOT for use with cars or karts!
Cars require the red TranX260 (Part No. 5010 or 5011).
Karts should use the yellow TranX160 (Part No. 9940 or 9941).
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Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
© Kuete et al.; licensee BioMed Central Ltd. 2012
Received: 4 May 2012
Accepted: 13 June 2012
Published: 20 June 2012
Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was aimed at evaluating the cytotoxicity of a naphtyl butanone isolated from the leaves of Guiera senegalensis, guieranone A (GA).
The results indicated that GA was active on 91.67% of the 12 tested cancer cell lines, the IC50 values below 4 μg/ml being recorded on 83.33% of them. In addition, the IC50 values obtained on human lymphoblastic leukemia CCRF-CEM (0.73 μg/ml) and its resistant subline CEM/ADR5000 (1.01 μg/ml) and on lung adenocarcinoma A549 (0.72 μg/ml) cell lines were closer or lower than that of doxorubicin. Interestingly, low cytotoxicity to normal hepatocyte, AML12 cell line was observed. GA showed anti-angiogenic activity with up to 51.9% inhibition of the growth of blood capillaries on the chorioallantoic membrane of quail embryo. Its also induced apotosis and cell cycle arrest. Ingenuity Pathway Analysis identified several pathways in CCRF-CEM cells and functional group of genes regulated upon GA treatment (P < 0.05), the Cell Cycle: G2/M DNA Damage Checkpoint Regulation and ATM Signaling pathways being amongst the four most involved functional groups.
The overall results of this work provide evidence of the cytotoxic potential of GA and supportive data for its possible use in cancer chemotherapy.
KeywordsAngiogensis Apoptosis Cytotoxicity Guieranone A Microarray Pharmacogenomics
Malignant diseases are responsible of approximately 13% of all deaths each year in the world. About 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world [1]. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths; Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths [1]. It is reported that cancer is the leading cause of death in the developed world and the second leading cause of death in the developing world [1]. In 2000, leukemia represented about 3% of the almost seven million deaths due to cancer that year, and about 0.35% of all deaths from any cause [2]. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was focused on the cytotoxic potential of a naphtyl butanone, a major component of the leaves of Guiera senegalensis, GA. This compound previously showed good antifungal activity against Cladosporium cucumerinum[3], strong antiplasmodial activity and high cytotoxicity towards two cancer cell lines: HCT-116 colon carcinoma and THP-1 human acute monocytic leukemia [4]. Interestingly, the complete chemical synthesis of GA was reported [5]. Therefore, we undertook the present work to highlight the anticancer potential of this compound and its possible effects on cell cycle distribution, apoptosis, transcript profiling using leukemia CCRF-CEM cells as a model. The study was also extended to the search of the anti-angiogenic potency of GA.
Chemical for cytotoxicity assay
Doxorubicin (Sigma-Aldrich, Schnelldorf, Germany) was used as a positive (cytotoxic) control. Captopril (Sigma-Aldrich) was used as positive anti-angiogenic control. GA was isolated from the methanol extract from the leaves of Guiera senegalensis; The leaves of the plant were collected in Mount Kala (Centre Region of Cameroon, Africa) in May 2008. The plant was identified at the Cameroon National Hebarium (Yaounde) were a voucher specimen was deposited. The air-dried and powdered leaves (1.5 kg) were soaked in 6 L of methanol for 48 h, at room temperature. The methanol extract was concentrated under reduced pressure to give 120 g of a Green-dark residue that constituted the crude extract (GSL). Part of this extract (100 g) was submitted to repeated silica gel 60 (0.04–0.063 mm, 200 g) and thin layer chromatography (TLC) to afforded GA C18H20O5 (light yellow crystals; 48 mg; m/z 316; m.p. 99–101°C) [3, 6] (Detailed isolation and general experimental procedures are available as Supporting information).
Cell lines treatment
A panel of fourteen cancer cell lines including human lymphoblastic CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000, MiaPaCa-2 and Capan-1 pancreatic adenocarninoma cells, MCF-7 breast adenocarcinoma cells, SW-680 colon carcinoma cells, 786–0 renal carcinoma cells, U87MG glioblastoma cells, A549 lung adenocarcinoma cells, Caski and HeLa cervical carcinoma cells, Colo-38 skin melanoma cells, as well as AML12 normal hepatocytes were used. Cell lines were obtained from different sources: Prof. Axel Sauerbrey, University of Jena, Jena, Germany (CCRF-CEM, CEM/ADR5000), Dr. Jörg Hoheisel, German Cancer Research Center, Heidelberg, Germany (MiaPaCa-2, Capan-1, MCF-7, SW-680), Tumor Bank, German Cancer Research Center, Heidelberg, Germany (786–0, U87MG, A549, Caski, HeLa, Colo-38), American Type Culture Collection,USA (AML12).
All cell lines were maintained in RPMI 1640 containing 100 units/ml penicillin and 100 μg/ml streptomycin and supplemented with heat-inactivated 10% fetal bovine serum (FBS). All cultured cells were maintained in a humidified incubator at 37°C with 5% CO2. Multidrug resistance of CEM/ADR5000 was maintained by applying 5000 ng/ml Doxorubicin every other cell passage. Doxorubicin (Sigma-Aldrich, Schnelldorf, Germany) was used as a positive (cytotoxic) control. The concentration of DMSO was kept at or below 0.1% in all experiments.
Resazurin cell growth inhibition assay
Alamar Blue or Resazurin (Promega, Mannheim, Germany) reduction assay [7] was used to assess the cytotoxicity of the studied samples. Doxorubicin was used as positive control. Each assay was done at least three times, with two replicate each. The viability after 48 h was compared based on a comparison with untreated cells. IC50 (on cancer cells) or EC50 (on AML12 cells) values were the concentration of sample required to inhibit 50% of the cell proliferation and was calculated from a calibration curve by a linear regression [8], using Microsoft Excel (The detailed Resazurin assay is available in Supporting information).
Flow cytometry for cell cycle analysis and detection of apoptotic cells
Leukemia CCRF-CEM cells treated with GA or DMSO (solvent control) for 24 to 72 h were fixed with ethanol 95% and washed with cold, phosphate-buffered saline (PBS; Invitrogen) and then resuspended in 150 μl hypotonic fluorochrome solution (50 μg/ml propidium iodide, 10 μg/ml RNAse A in PBS). The cells were incubated in the dark at 4°C overnight before flow-cytometry analysis was performed. The propidium iodide fluorescence of individual nuclei was measured using a FACS-Calibur cytometer (BD Biosciences, Heidelberg, Germany). Data were analyzed with the CellQuess Pro V5.2.1 software (BD Biosciences). For each condition, at least three independent experiments were performed.
Caspase-glo 3/7 assay
The influence of GA on caspase 3/7 activity in CCRF-CEM leukemia cells was detected using Caspase-Glo 3/7 Assay kit (Promega). Cells cultured in RPMI were seeded in 96-well plates and treated with the sample (2 × IC50; IC50; ½ × IC50) or DMSO (solvent control). After 24 h treatment, 100 μl of caspase 3/7 reagent were added to each well, mixed and incubated for 1 h at room temperature. Luminescence was measured using well Infinite M2000 Pro™ instrument (Tecan). Caspase 3/7 activity was expressed as percentage of the untreated control.
Detection of angiogenesis in vivo by cultivation of quail eggs
The quail eggs were purchased from Wachtelzucht Anne Klein, Steinhagen, Germany. The embryos were cultured according to the method described by Wittmann et al. [9]. GA and captopril (as positive control drug) were tested for their anti-angiogenic effects at 20 μg/ml, using chicken chorioallantoic membrane assay (CAM assay) method as described by D'Arcy and Howard [10], with modifications according to Marchesan et al. [11]. The percentage inhibition of vascularization was calculated as previously described [12] (Detailed anti-angiogenic tests are available in Supporting information).
mRNA-based microarray expression profiling
RNA isolation and analysis
Total RNA from CCRF-CEM cells was isolated using RNeasy Kit from Qiagen (Hilden, Germany) according to the manufacture's instruction. RNA was resuspended/eluted in TE/water. The quality of total RNA was checked by gel analysis using the total RNA Nano chip assay on an Agilent 2100 Bioanalyzer (Agilent Technologies GmbH, Berlin, Germany). Only samples with RNA index values greater than 8.5 were selected for expression profiling. RNA concentrations were determined using the NanoDrop spectrophotometer (NanoDrop Technologies, Wilmington, DE).
Probe labeling and illumina sentrix BeadChip array hybridization
Biotin-labeled cRNA samples for hybridization on Illumina Human Sentrix-HT12 BeadChip arrays (Illumina, Inc.) were prepared according to Illumina's recommended sample labeling procedure based on the modified Eberwine protocol [13] (Detailed tests is available in Supportive information).
Scanning and data analysis
Microarray scanning was done using a Beadstation array scanner, setting adjusted to a scaling factor of 1 and PMT settings at 430. Data extraction was done for all beads individually, and outliers are removed when > 2.5 MAD (median absolute deviation). All remaining data points are used for the calculation of the mean average signal for a given probe, and standard deviation for each probe was calculated.
Data analysis was done by normalization of the signals using the quantile normalization algorithm without background subtraction, and differentially regulated genes are defined by calculating the standard deviation differences of a given probe in one-by-one comparisons of samples or groups.
All data is MIAME compliant and the raw data has been deposited in a MIAME compliant database as detailed on the MGED Society website http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-731 (Accession number E-MTAB-731).
Real-time (RT)-PCR
The same RNA samples used for microarray experiment were also used for RT-PCR experiments. RNA samples extracted from cells treated with GA or DMSO (solvent control) were converted to cDNA by reverse transcriptase (Invitrogen) using random hexamerprimers. The cDNAs were quantified by real-time PCR using the SsoFast EvaGreen PCR Kit (Bio-RAD, München, Germany) and the CFX384TM Real-Time PCR Detection Systems (Bio-RAD), PCR was done by initial incubation at 50°C for 10 min, denaturation at 95°C for 5 min and 40 cycles were performed in two steps for each: denaturation at 95°C for 30 s, annealing at 62°C for 40 s. Melt Curve was performed by cooling from 95°C to 65°C, followed by a gradual increase in temperature (0.5°C/5 s) to 95°C. Expression levels were normalized relative to the transcription level of G6PD. All samples were run in triplicate.
Statistical analysis
Statistical analysis of all data was performed using a Student's t-test or Kruskal–Wallis test followed by Dunn's post-hoc multiple comparison test (Graph-Pad Prism 5.01; GraphPad Software, Inc., CA, USA). P < 0.05 denoted significance in all cases.
Cytotoxicity of Guieranone A and Doxorubicin in various cancer cell lines
Cell lines
Sample and IC50values
Guieranone A
0.73 ± 0.11
2.31 ± 0.35
0.62 ± 0.003
1.14 ± 0.005
1.01 ± 0.09 (1.38)
3.19 ± 0.28
>20 (>32.26)
3.91 ± 0.25
12.37 ± 0.79
0.95 ± 0.06
1.75 ± 0.11
9.19 ± 2.29
29.08 ± 7.24
4.06 ± 1.18
7.47 ± 2.17
1.08 ± 0.32
3.42 ± 0.90
0.59 ± 0.05
1.08 ± 0.09
0.93 ± 0.09
1.71 ± 0.17
3.68 ± 0.54
11.32 ± 1.70
0.60 ± 0.09
1.10 ± 0.17
2.46 ± 0.02
7.78 ± 0.05
0.37 ± 0.08
0.68 ± 0.14
0.72 ± 0.07
2.28 ± 0.22
1.69 ± 0.05
3.11 ± 0.09
2.43 ± 0.75
7.69 ± 1.38
0.81 ± 0.06
1.49 ± 0.11
0.51 ± 0.04
1.61 ± 0.13
0.26 ± 0.02
0.48 ± 0.04
1.18 ± 0.11
3.73 ± 0.35
0.58 ± 0.02
1.07 ± 0.04
Anti-angiogenic effect of guieranone A
Cell cycle analysis and apoptosis
Microarray analysis and signaling pathway profiling
Ten most down- or up-regulated genes in CCRF-CEM cells after treatment guieranone A
Fold Change
Up-regulated genes
heat shock 70 kDa protein 6 (HSP70B)
histone cluster 1, H2bd
FBJ murine osteosarcoma viral oncogene homolog B
histone cluster 2, H2aa4
CD52 molecule
histone cluster 2, H2aa4
jun oncogene
heme oxygenase (decycling) 1
RAB37, member RAS oncogene family
trafficking protein particle complex 6A
Down-regulated genes
dehydrogenase/reductase (SDR family) member 2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
THO complex 4
heterogeneous nuclear ribonucleoprotein A1 pseudogene 2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
dehydrogenase/reductase (SDR family) member 2
actin, beta-like 3
phosphoglycerate mutase 1 (brain)
actin, beta
ID (Network)
Focus molecules
Top functions*
List of all molecules involved
Molecular transport, Protein trafficking, Cellular assembly and organization
ACP1, ATP1A1, DDX21, DDX3X, DOK2, ERK1/2, GC-GCR dimer, GNL3, Histone h3, Histone h4, HNRNPH1, HNRNPK, Importin alpha, Importin beta, KPNA2, KPNB1, LARP1, LYAR, NCL, NDRG1, NUP62, NUP153, RANBP1, Rnr, RRP1B, RRS1, SLBP, THOC4, TNFRSF8, TNPO1, TPX2, TSC22D3, TSR1, WDR12, YBX1
Drug metabolism, endocrine System development and function, lipid metabolism
ACTB, Actin, ACTL6A, Akt, alcohol group acceptor phosphotransferase, CS, FASN, HMGA1, HNRNPL, HSP90AB1, IARS, IKK (complex), IPO4, KEAP1, Lamin b, MAP3K8, MCM3, MCM4, MORF4L2, MYCN, ORC6L, PDCD6IP, PSMD6, PTGES3 (includes EG:10728), RNF4, RPL6, RPL7A (includes EG:6130), RPS24 (includes EG:6229), RUVBL1, SGK1, SLC38A2, SMC3, Thyroid hormone receptor, TIP60, TUBB
Cell death, cell-to-cell signaling and interaction, cellular function and maintenance
14-3-3, ACAT2, AHCY, APIP, ARF3, CD3, CD52, CTPS, FAM83D, FOSB, FOXO3, GADD45B, HBP1, HNRNPAB, HSPA6, IL10RB, Immunoglobulin, KIF23, LMNB1, Mapk, Mek, MVP, PDGF BB, Pld, PPHLN1, PPP1R15A, PRDX3, PRKCB, RBCK1, RGS2, TCR, UTP14A, VIM, YWHAE, YWHAG
Cell cycle, cancer, gastrointestinal disease
ADAR, APC, CCNA2, CDK1, CDKN3, CHEK1, CNOT7, Cyclin A, DHFR, E2f, FBXO5, FEN1, H2AFY, ID2, IFI16, KIAA0101, MAD2L1, MAP2K1/2, methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase (NADP), Mre11, MTHFD1, MTHFD2, MTHFD1L, NBN, NUSAP1, PI3K (complex), PRIM1, Rb, RFC4, TFDP1, TINF2, TYMS, WEE1, XRCC5
Real time RT-PCR
To verify the microarray data with a second independent method, RT-PCR was exemplarily performed for some differentially regulated genes (i.e. ACTB, GADD45, HSP90AB1, LYAR as well as for G6PD as reference). All results were in accordance with the microarray results (see Additional file 1: Figure S6).
In the US NCI plant screening program, a compound is generally considered to have in vitro cytotoxic activity, if the IC50 value following incubation between 48 and 72 h, is less than 4 μg/ml or 10 μM [14]. In the present work, the IC50 values below 4 μg/ml were recorded on 11/14 (75.57%) of the studied cancer cells, clearly highlighting the good cytotoxicity potential of GA. In addition, values obtained on CCRF-CEM (IC50 of 0.73 μg/ml) and its multidrug-resistant subline, CEM/ADR5000 (1.01 μg/ml), A549 (0.72 μg/ml) were closer or lower than that of doxorubicin, clearly confirming this statement. Besides, GA was active on multidrug-resistant CEM/ADR5000 cells, suggesting that this compound might be useful for cancer therapy, including tumor cells resistant to some of the commonly used anticancer drugs. As the liver is the main organ involved in drug metabolism, AML12 normal hepatocytes were used to evaluate the cytotoxicity of GA in normal cells. Interestingly, the EC50 > 20 μg/ml obtained was higher than the values obtained against most of the cancer cells (Table 1). The overall results of the cytotoxicity assay indicated that GA might be a promising candidate as new anticancer drug. Therefore, further studies were conducted to investigate the possible mode of action of this compound.
Anti-angiogenic effect of guieranone A
Angiogenesis, the formation of new blood vessels within a tumor (or many other tissue types) has become a target of pharmacological research as well as industrial drug discovery [15]. Compounds with anti-angiogenic properties are of importance in the treatment and prevention of malignancies as well as other chronic diseases [16]. Though GA showed less antiangiogenic activity than captopril, the result obtained indicates that, in addition to direct cytotoxicity on cancer cells, this compound could also inhibit the proliferation of blood vessels in vivo, presumably with negative effect on tumor progression.
Cell cycle analysis and apoptosis
The low induction of apoptosis at the early stage of CCRF-CEM cells proliferation is in consistence with the caspase 3/7 activity study (Additional file 1: Figure S1), as low activation of these apoptosis effectors was noted upon 6 h. However, higher apoptosis rates were finally obtained after 72 h with all tested concentrations, showing that apoptotic pathways are involved in the mechanism of GA-induced cell death in CCRF-CEM leukemia cells. Therefore, in vivo bioavailability and bioactivity studies are also to be carried out with this compound, as GA showed promising in vitro activities but induces apoptosis upon a long time period (72 h).
Microarray analysis and signaling pathway profiling
The cell cycle arrest in CCRF-CEM cells was early detected after 24 h and the down regulation of important genes such as CHK1 and WEE1, as reported above might plays a considerable role. This allegation is strengthened by the fact that one of the key players in cell cycle regulation such as GADD45 is also up-regulated following GA treatment (Additional file 1: Figure S1).
HSPA6 (heat shock 70 kDa protein 6) and HIST1H2BD (histone cluster 1, H2bd) genes were found to be most up-regulated upon GA treatment. In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (http://www.uniprot.org). Interestingly, 70 kDa heat shock protein protects cells from ischemia and its expression is increased in consequence to hypoglycemia [17, 18]. In addition, closely connected genes to HSPA6, HSPA1A and DNAJB2, were found to be up-regulated in our anaylses. Whereas HSPA1A is coding for heat shock 70 kDa protein 1A/1B, DNAJB2 has as protein product cochaperon Hsp40 (DNAJ in bacteria) which is essential for Hsp70 function [19]. Interesting genes which are up-regulated included FOSB and JUN. A combined up-regulation of these genes with Hsp70 mRNA was earlier observed in as stress response to high acceleration [20]. This finding also confirmed the assumption that GA might cause hypoxic stress. Through high acceleration an induction of ischemia can be observed [20]. Furthmore, dimerization of protein products of FOSB (a FOS family member) and JUN constitute the transcription factor AP-1 which is activated by oxidative stress [21]. Surprisingly, a cofactor of JUN-activated transciption, DDX21, belonged to one of the most down-regulated genes in our microarray analysis [22]. This findings give reason to speculate that GA might mimic under-supply of oxygen or glucose and, therefore, leads to apoptosis (see also Figure 2). Very interesting in the contest of the latter assumption was that GA inhibited angiogenesis (Figure 1). It would be worthwhile to investigate, whether the vascular endothelial growth factor (VEGF), its secretion or even the VEGF receptor are inhibited by GA leading to interrupted VEGF signaling, as normally VEGF is activated under hypoxic conditions [23]. Thereby, the fact that we did not observed any significant change in VEGF mRNA expression (See Additional file 1: Table S3) does not mean that VEGF signaling was not targeted by GA. VEGF protein expression can independently vary from corresponding mRNA amounts in the cell [24].
Certain histone mRNAs were also up-regulated after treatment with GA HIST1H2BD, HIST2H2AC, HIST2H2AA4 (Table 3)]. This observation is surprising, as levels of histone mRNA usually increase during S-phase, but decrease back to baseline level between the S-phase and mitosis [25]. This finding was also confirmed by our FACS analyses showing that cells treated with 1 × IC50 of GA for 72 h were more often arrested in the S- or G2/M phases than untreated control cells (see also Figure 2.C2 and D2).
CD52 is a membrane protein which is discussed as target molecule for leukemia therapy [26]. Alemtuzumab is an antibody directly targeting CD52 and already approved for clinical use [27]. In our experiments, the mRNA of this protein was strongly up-regulated. A combined treatment of GA with Ametuzumab may possibly boost the apoptotic effect of both drugs, as GA might sensitize cells to Alemtuzumab by inducing CD52 expression and activating CD52 downstream mechanisms. This speculations merits further experimentation in the future.
ACTB and ACTBL3 belonged to the most down-regulated genes. Beta-actin mRNA levels are known to be disturbed after ischemia [28], which is in line with our assumption that GA may mimic hypoxia. Another gene fitting to our hypothesis is PGAM1, which codes for phosphoglycerate mutase in glycolysis. Another gene coding for a protein similar to phosphoglycerate mutase processed protein was also down-regulated by GA, LOC728188. Down-regulation of glycolysis key molecules accompanied by hypoxic stress may destroy the entire energy production apperture ultimately leading to cell death. The mis-regulation in glyco-related mechanisms was also indicated by down-regulation of DHRS2, whose encoded protein preferentially binds to glucose and related sugars [29].
KPNA2 codes for importin alpha. This protein is a key player in the nuclear transport of macromolecules [30]. Moreover, HNRNPA1P2 is rarely investigated yet, but seems to be involved to mRNA transport from the nucleus to cytosol (according to UniProt database, http://www.uniprot.org). THOC4 encoding a more investigated mRNA transporter molecule was also significantly down-regulated. The THOC4 protein is part of the TREX complex, which specifically associates with spliced mRNA [31]. THOC4 is especially involved in nuclear export of Hsp70 transcripts [32].
Interestingly, RAB37 and TRAPPC6A encode also two proteins which are also involved to transport mechanisms (http://www.uniprot.org). They were also mis-regulated in their transcriptional activity after GA treatment. In summary, it seems that transport mechanisms are de-regulated as consequence of treatment with this compound.
Recapitulating, GA seems to cause hypoxia and hypoglycemia as several genes of these functions were affected. Furthermore, a considerable de-regulation of several protein- and mRNA-transporter genes was observed. The latter findings was also confirmed by Ingenuity Pathway Analyses of the microarray data pointing to "Molecular Transport" and "Protein Trafficking" with highest score (Table 3; Figure 3). In contrast, no molecules belonging to the other hits of Table 3 were found to be extremely up- or down-regulated.
In the signaling networks of Figures 3 and 4, more key players become apparent which do not belong to most mis-regulated genes in our investigation: HNRNPK LYAR and YBX1. According to UniProt database, HNRNPK is involved in RNA processing and splicing. However, it is interesting from our point of view that it seems to be important for enhanced proliferation, as increased levels of HNRNPK mRNA correlates with increased proliferative activity [33]. LYAR is a gene involved in development and cell growth regulation and especially for leukemia cells, as mRNA levels are increased, but LYAR mRNA is not or only less expressed in cells of different healthy tissues, e.g. thymus, bone marrow, liver, heart, brain, kidney or spleen [34]. YBX1 encodes for a protein, YB-1, which is involved in many mechanisms: proliferation, mRNA processing, DNA repair, transcription, splicing and drug resistence [35]. The relation of YB-1 to drug resistance is due to its activation of the multidrug resistance gene, MDR1[36]. In addition, YBX1 expression is also important for deregulation of the oncogene, MYCN[37] (Figure 3B).
MYCN is a prominent transcription factor important for tumorigenesis and chemotherapy. MYCN mRNA was found to be over-expressed in human tumor biopsies [38]. Directly correlated to this finding is the down-regulation of RUVBL1 mRNA (Figure 3B) encoding a protein which binds to MYC [39]. It is essential for cell proliferation. In addition, the RUVBL1 protein is associated with the activation of NuA4 histone acetyltransferase complex, which is associated to the de-regulated histone mRNAs mentioned above [40]. Finally, SGK1 up-regulation is very interesting, as the encoded protein might counteract the cytotoxic activity of GA and activate cell survival processes. It deserves more detailed investigations in the future to elucidate the connection between KPNA2 and SGK1, as recognition by importin alpha of Sgk (protein of SGK1 gene) might be necessary for nuclear import of activated SGK1 [41].
Furthermore, there is another connection between SGK1 (Figure 3B) and FOXO3A (Figure 4A). FOXO3A is a pro-apoptotic protein which is regulated by SGK1 [42]. FOXO3A has also an important role as transcription factor in oxidative stress reponse and cell protection [43]. Its role in cellular response to GA needs further investigations, because the activity of FOXO3A protein is controlled by phosphorylation, which was not measured in our mRNA expression profiling approach. Another prominent member involved in cell death mechanisms is YWHAG, which codes for 14-3-3 gamma protein [44]. 14-3-3 proteins are directly involved in apoptosis and cell survival regulation by inhibiting BAD and FOXO3A [45]. In summary, the signaling network shown in (Figure 3B) depicts genes related to cell survival.
The overall results of the present investigation strengthened the cytotoxic potency, the effect on cell cycle distribution, apoptosis, angiogenesis of Guieranone A, and consequently give important information for the future investigation, that could lead to the potential use of this compound in cancer therapy.
Authors are thankful to the National Herbarium of Cameroon (Yaounde) and Mr. Thabet Belkacemi for their technical supports. VK is also very grateful to the Department of Pharmaceutical Biology, Johannes Gutenberg University, Mainz, Germany and to the Alexander von Humboldt foundation for the 18 month postdoctoral fellowship in Germany.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Top Definition
To tell someone that you have taken care of the afore mentioned problem or idea.
"Harry I took care of it" hitcoi
by Brenton Razor November 28, 2006
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text:
JOINT BASE MAGUIRE-DIX-LAKEHURST, N.J. -- Soldiers from the New York Army National Guard's 1156th Engineer Company fire the M240B machine gun during Annual Training here. Unit members also repaired buildings at the training location.
DMNA Press Releases
NY National Guard In the News
Associated Press -- Wed, 07 Oct 2015 NY creek debris blamed for Connecticut teen's death removed SHANDAKEN, N.Y. (AP) - Debris in a Hudson Valley creek that led to the drowning death of a teenage Connecticut girl has been cleared away.
Associated Press -- Wed, 07 Oct 2015 NY Air Guard unit completes 1st solo drone combat mission NIAGARA FALLS, N.Y. (AP) - A western New York-based Air National Guard unit that has made the shift from flying manned aircraft to operating remotely piloted drones has completed its first... (more)
Department of Defense -- Tue, 06 Oct 2015 New York Guardsmen Prepare for Hurricane Joaquin (Photo Essay) Guardsmen operate heavy equipment to clear space near Normanskill Creek in Albany, N.Y., Friday, Oct. 2, 2015 as part of New York's preparations for the possible landfall of Hurricane... (more)


text:
Release Date:
June 4, 2002
Rating: r - Not For Children, Nudity, Profanity, Strong Sexual Content, Graphic Violence, Substance Abuse
Director David Lynch crafted this hallucinogenic mystery-thriller that probes beneath the cheerful surface of suburban America to discover sadomasochistic violence, corruption, drug abuse, crime and perversion. Kyle Maclachlan stars as Jeffrey Beaumont, a square-jawed young man who returns to his picture-perfect small town when his father suffers a stroke. Walking through a field near his home, Jeff discovers a severed human ear, which he immediately brings to the police. Their disinterest sparks Jeff's curiosity, and he is soon drawn into a dangerous drama that's being played out by a lounge singer, Dorothy Vallens (Isabella Rossellini) and the ether-addicted Frank Booth (Dennis Hopper). The sociopathic Booth has kidnapped Dorothy's young son and is using the child as a bargaining chip to repeatedly beat, humiliate and ****** Dorothy. Though he's drawn to the virginal, wholesome Sandy Williams (Laura Dern), Jeff is also aroused by Dorothy and in trying to aid her, he discovers his dark side. As the film nears its conclusion, our hero learns that many more indivduals are tacitly involved with Frank, including a suave, lip-synching singer, Ben (Dean Stockwell), who is minding the kidnapped boy. Director Lynch explored many similar themes of the "disease" lying just under the surface of the small town, all-American façade in his later television series Twin Peaks (1990-91). ~ Karl Williams, Rovi
- Genre: Mystery
- Category Post-Noir (Modern Noir), Crime Thriller, Americana
- Theme: Suburban Dysfunction, Woman In Jeopardy, Innocence Lost, Amateur Sleuths
- Run Time: 02 hr 01 min
- Language: French , English , Spanish
- Subtitle Language: Spanish , English , French , Portuguese
- Picture Format: widescreen
- Lead Actor: Laura Dern , Dennis Hopper , Isabella Rossellini , Kyle MacLachlan , Hope Lange
- Supporting Actor: Philip Markert , Selden Smith , Peter Carew , Fred Pickler , J. Michael Hunter , Angelo Badalamenti , A. Michelle Depland , Jean Pierre Viale , Kate Reid , Moses Gibson , Dick Green , Jon Jon Snipes , Leonard Watkins , Donald Moore , Michelle Sasser , Dean Stockwell , Brad Dourif , Jack Nance , George Dickerson , Jack Harvey , Priscilla Pointer , Ken Stovitz , Frances Bay
- Director: David Lynch
- Golden Globe Awards (2), Academy Awards (1)
- Golden Globe Awards , Best Performance by an Actor in a Supporting Role , 1986 , Dennis Hopper
- Academy Awards , Best Director , 1986 , David Lynch
- Golden Globe Awards , Best Screenplay , 1986 , David Lynch
other Info.
- Online Item #: 11329440
- Store Item Number (DPCI): 246-00-3386
- Made in the USA or Imported


text: I'm not going to lie, what I just read is the dumbest thing I've read in my life. I'm not trying to be overly or unnecessarily critical, either. It just really, truly, is the dumbest thing I've ever read. I had to read it three times to make sure it wasn't the Onion. Charisma Mag (I [Read More...]


text:
Like many things, from roller skating, kayaking, sailing, and camping/road trips (I'm sort of a tom-boy) to the theater, opera, concerts (music and dance), art shows (I can rock a little black dress). Willing to try anything at least once. Zumba, dance classes, yoga/pilates are my stress relievers. Taking swing dance classes now and hope to learn how to salsa too. Tango anyone?
I'm told I look young for my age and I'm trying to believe it. I'm independent, adventurous, playful, curious and partially domesticated; perhaps eccentric. I've been called a "sexy bohemian". I'm a loyal and generous friend and love old people, children and small animals ;-).
Spending time with friends; good conversation over a glass of wine and walking all over the place in Florida, San Francisco, Scotland and even Cleveland is my favorite pastimes. Walking from Pacific Heights over the Golden Gate Bridge to Sausalito is on of my favorite SF hikes. Sailing the Bay would be awesome. I love the streets and neighborhoods of cities as much as wooded trails and beachfront sunsets.
My ideal date would be someone who is a great communicator who can carry on a conversation; bonus points for a good storyteller. He would love good food, good wine, sunsets on the beach and winter days in the woods. Theater, art and music would be of interest to him and he may even write, paint or play music himself; an adventurer who loves to discover new places and things. I'm sure he's out there.....................some where.
I am not lonely, desperate or needy. I am perfectly capable of going to a movie, concert, the theater, out to dinner or even to Spain by myself. I am looking for someone with similar interests who wants to spend the time it takes to establish a relationship and to share the things I love.
I'm NOT looking for casual sex or married men. I am not interested in tattoos, piercings, powerboats, motorcycles and anyone who is over weight. Do NOT message me if you think a date is making an appointment for sex. This is a DATING site, if you're looking for a hookup go to Tinder. If you're really only interested in emailing, texting, chatting online or talking on the phone, please look elsewhere. You can't tell anything about anyone until you meet them in person, so if you're really not interested in meeting please move on. I won't respond to any one not posting a picture. I don't believe in long distance relationships, so if you live far away I will thank you for your interest, but after that there will be no response.


text:
>>>>> "Flavio" == Flavio C Coelho <fccoelho@...> writes:
Flavio> John, is there a way, in matplotlib, to emulate the
Flavio> behavior of the matlab "hold" comand to plot multiple
Flavio> datasets on a single figure?
The default behavior in matplotlib is 'hold on'.
plot(x1, y1)
plot(x2, y2)
Both plot to the same figure.
This is one way in which matplotlib differs from matlab.


text: African Participation in the United Nations, 1961-1965 Riggs, Robert E. economic aid Gross National Product international relations memberships military strength participation population size United Nations IDRC.VIII ICPSR.XI.B.2 IDRC.I This data collection provides information on the participation of 25 African member nations of the United Nations (UN) in the UN in the period 1961-1965. Data are provided for national attributes, and forms of participation in the UN. National attributes data provide information on the gross national product (GNP), United States' economic and military aids received, size of the armed forces, population size, number of physicians per 100 inhabitants, and school enrollment as a percentage of the population. Data on participation in the UN include the number of representatives from each nation in the UN, number of offices won, and resolutions and amendments passed. 1992-02-16 administrative records data aggregate data survey data 5516 10.3886/ICPSR05516.v1 United Nations publications Africa Benin Burkina Faso Cameroon Chad Democratic Republic of Congo Egypt Ethiopia Gabon Ghana Global Guinea Ivory Coast Liberia Libya Madagascar Mali Morocco Niger Nigeria Senegal Somalia Sudan Syria Togo Tunisia 1961--1965 ICPSR metadata records are licensed under a Creative Commons Attribution-Noncommercial 3.0 United States License (http://creativecommons.org/licenses/by-nc/3.0/us/).


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text:
Book your room at Econo Lodge
Standard Room, 2 Double Beds, Non SmokingMax Occupancy: 4 guests (up to 3 children, 2 infants)
Standard Room, 1 Queen Bed, Non SmokingMax Occupancy: 2 guests (up to 1 child, 1 infant)
Get an overview of this hotelMotel in Forestville with restaurant and bar/lounge
Located in the heart of Forestville, this motel is within 1 mi (2 km) of Golf le Meandre and Musee Petite Anglicane. Forestville Ferry Terminal is 1.9 mi (3.1 km) away.
Property Features
This motel features a restaurant, a bar/lounge, and a business center. Self parking is free. Additionally, conference rooms, meeting rooms, and dry cleaning are onsite.
Room Amenities
All 55 rooms offer coffee makers, TVs with cable channels, and free local calls. Hair dryers, phones, and ironing boards are among the other amenities that guests will find.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
The motel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. Business-related amenities consist of a business center and meeting rooms.
Event facilities measuring 6574 square feet (611 square meters) include conference space. This Forestville motel also offers tour/ticket assistance, multilingual staff, and dry cleaning/laundry services. Complimentary self parking is available on site.
Econo Lodge has designated areas for smoking.
- Babysitting or childcare (surcharge)
- Bar/lounge
- Business center
- Conference space
- Conference space size (feet) - 6574
- Conference space size (meters) - 611
- Designated smoking areas
- Dry cleaning/laundry service
- Free self parking
- Meeting rooms
- Multilingual staff
- Number of floors - 1
- Number of meeting rooms - 5
- Restaurant
- Total number of rooms - 55
- Tours/ticket assistance
Free self parking
Room Amenities
- Cable TV service
- Coffee/tea maker
- Free local calls
- Hair dryer
- Iron/ironing board
- Phone
- Television
Where to Eat
Damube Bleu - Onsite restaurant.
Nearby Things to Do
- Golfing nearby
Hotel Policies
Check-in time starts at 2 PM
Check-out time is noon
Children and extra beds
- Children are welcome.
Pets allowed, Maximum number of pets per room 1, Pet maximum weight in lb is 10
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
We should mention
Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation.


text:
Book your room at Holiday Motel
One king bed non smokingMax Occupancy: 3 guests (up to 2 children, 1 infant)
Two double beds non smokingMax Occupancy: 6 guests (up to 5 children, 1 infant)
Get an overview of this hotelFamily-friendly hotel with water park and free breakfast
This family-friendly Fresno hotel is located on the Strip, within 1 mi (2 km) of Roeding Park, Rotary Storyland & Playland, and Fresno Chaffee Zoo. Rotary Storyland and Playland and 2nd Space Theater are also within 3 mi (5 km).
Hotel Features
Along with a water park, this hotel has coffee/tea in the lobby and a business center. Free continental breakfast, free WiFi in public areas, and free self parking are also provided. Additionally, laundry facilities, a 24-hour front desk, and express check-in are onsite.
Room Amenities
All rooms are individually furnished and offer free WiFi and free local calls. Guests can appreciate conveniences like refrigerators and microwaves, and other amenities include premium bedding and satellite TV.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Holiday Motel features a water park. High-speed wireless Internet access is complimentary. This hotel offers access to a business center. Guests can enjoy a complimentary breakfast each morning. This family-friendly hotel also offers coffee/tea in the lobby, laundry facilities, and express check-in. Onsite self parking is complimentary.
Holiday Motel has designated areas for smoking.
- 24-hour front desk
- Business center
- Coffee/tea in lobby
- Designated smoking areas
- Express check-in
- Express check-out
- Free breakfast
- Free self parking
- Free WiFi
- Laundry facilities
- Number of floors - 2
- Tennis on site
- Total number of rooms - 50
- Water park
Family Friendly Amenities
- Free Wi-Fi
- Laundry facilities
- Microwave
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Access via exterior corridors
- Air conditioning
- Bathtub or shower
- Climate control
- Free bottled water
- Desk
- Free local calls
- Free WiFi
- Hair dryer (on request)
- Individually furnished
- Iron/ironing board (on request)
- Microwave
- Phone
- Premium bedding
- Premium TV channels
- Private bathroom
- Refrigerator
- Satellite TV service
Where to Eat
Guests are offered a complimentary continental breakfast each morning.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Golf lessons available nearby
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 21
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! One child under 12 years old stays free when using existing bedding.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Minimum guest age is 18
No rollaway/extra beds available
No cribs (infant beds) available
No elevators
We should mention
One child 12 years old or younger stays free when occupying the parent or guardian's room, using existing bedding. Only registered guests are allowed in the guestrooms. Alcohol is not served at this property.


text:
El Al reinstates Eilat flights after safety concerns
El Al Airlines halted flights to the southern resort city of Eilat, after questioning the safety of new flight paths. More ▸
El Al Airlines halted flights to the southern resort city of Eilat, after questioning the safety of new flight paths. More ▸
The Israeli government has advised Israelis and all Jews to avoid travel to several countries, including Egypt and Turkey, during the High Holidays, a popular time for leisure travel. More ▸
Six Egyptians were killed and 11 injured in attacks in the Sinai Peninsula near the Israeli border. More ▸
The Egyptian military has asked Israel to allow it to send troops into the Sinai Peninsula for an offensive against terrorists there. More ▸
Israel confirmed that it is holding a Palestinian man who disappeared in the Sinai Peninsula for "security crimes." More ▸
Islamist terrorists are targeting Arab-Israelis in the Sinai, a London-based Arabic newspaper reported. More ▸
Political convulsions in Egypt are raising the specter of instability along Israel's southern border. But many Israelis are hopeful the removal of the Muslim Brotherhood from power portends a return to a more familiar state of affairs — or even better. More ▸
Armed men in the Sinai took two tourists captive, including an Israeli. More ▸
Egyptian authorities seized one ton of explosives headed for Gaza. More ▸
Egyptian security forces in the Sinai Peninsula reportedly intercepted a shipment of American-made missiles destined for the Gaza Strip. More ▸
Also From 70 Faces Media


text:
Alabama college plan hit with investment drop
Posted: 03/04/2009 - Alabama's prepaid college tuition program is scrambling to figure out how to keep paying students' tuition now that its investments are tumbling and its tuition costs are rising.
Posted: 03/04/2009 - Alabama's prepaid college tuition program is scrambling to figure out how to keep paying students' tuition now that its investments are tumbling and its tuition costs are rising.
Updated: 03/04/2009 - WTVY sister statiom in Panama City has learned the body that was discovered Tuesday in a wooded area in Port St. Joe has been identified.
Updated: 03/04/2009 - Enterprise police have arrested a Dale County man on drug charges.
Updated: 03/04/2009 - A raccoon received by the Environmental Health Division of the Jackson County Health Department a few weeks ago has tested positive for rabies according to lab results received from the Department of Health Pensacola Branch Lab.
Posted: 03/04/2009 - An Alabama House committee has approved a bill that would treat fatal boating accidents involving alcoholic beverages the same as fatal traffic accidents where the driver of one of the vehicles was driving under the influence.
Posted: 03/04/2009 - President Barack Obama says he plans to name Florida's state emergency director to lead the Federal Emergency Management Agency.
Updated: 03/04/2009 - Emergency responders from Georgia and Alabama are putting their skills and training to the test at the Farley Nuclear Plant.
Posted: 03/04/2009 - The Emerald Coast chapter of the American Cancer Society invites the community to get "Back in the Saddle" for the second annual Cattle Barons' Ball
Updated: 03/04/2009 - Camp Brave Heart is designed for children, ages 7-14, who have experienced the loss of a loved one
Updated: 03/04/2009 - The Internal Revenue Service is getting reports of people receiving e-mails that appear to be from the IRS and that promise the recipient a stimulus payment in return for disclosing personal information.
Updated: 03/04/2009 - Bill to keep part of stimulus package is now in the state senate
Posted: 03/04/2009 - Alabama state troopers are trying to determine if alcohol was involved in a single vehicle accident that left one person dead and two others injured in Dale County.
Updated: 03/04/2009 - Police have responded to shootings two straight weekends in or around Club Rio Grande in downtown Dothan.
Posted: 03/03/2009 - A new organization consisting of faith-based groups, volunteer organizations, and others will have a plan in place in the event of a manmade or natural disaster in Coffee Co.
Posted: 03/03/2009 - A New Brockton council would like to reduce the police force and take other measures to reduce its costs.
Updated: 03/03/2009 - The search for a missing 2-year-old Kentucky girl has ended with the girl and her father found in Mexico.
Posted: 03/03/2009 - A business Beth Shiver and her late husband built together 30 years ago gone in less than an hour early Tuesday morning.
Posted: 03/03/2009 - Blockbuster has hired the law firm of Kirkland & Ellis to help rescue the struggling video store chain from a financial bind.
Posted: 03/03/2009 - Some say the nuisances at Solomon Park have been going on for years. Now over the past several months the city of Dothan has been working with residents to solve them once and for all.
Updated: 03/03/2009 - A badly decomposed body was found Tuesday afternoon in a wooded area at the intersection of North Park and Avenue A, in Port St. Joe.
Updated: 03/03/2009 - Bay County Sheriff's arrested an Alabama couple for having a Meth Lab in their motel room.
Posted: 03/03/2009 - The Florida Highway Patrol will be holding a roadside sobriety safety checkpoint on Friday, March 06 in the city limits of Crestview.
Updated: 03/03/2009 - The website offers detail about state spending.
Updated: 03/03/2009 - School systems in Brewton and Ozark are the first to receive grants from Gov. Bob Riley under a new program to encourage the use of biodiesel in Alabama school buses.
Posted: 03/03/2009 - The Okaloosa County Sheriff's Office of Professional Standards is launching internal investigations to determine whether or not three individuals within the department violated agency policies and procedures.


text:
Posted by a Business client
Ray counseled and setup my business for me over three years ago. I needed this completed quickly and Ray made it happen. He worked with me step by step to ensure all the paperwork that I was responsible for was submitted in a completed and timely manner.
In 2008, I needed Ray's help again with another business matter. Ray quickly came up to speed on the business structure and gave me several options to take. Although he was in the middle of many other obligations at the time, he always took the time to get back with me and keep me informed.
Posted by a Workers Compensation client
Posted by a Car Accident client
Mr Hatcher has helped me with 2 cases and he is always very willing to help and his staff assist him in every way possible to ensure sucess in his cases.
Mr. Hatcher takes the time to know his clients and know their needs which many times go unrecognized with other attorneys.
I have recommended him to several friends and I know he has always gone the extra mile.
In in scale of 1 -10 I would rate him as a '10'
Posted by a Litigation client
I have worked with Ray Hatcher on several cases and he has always demonstrated knoweldge, skill and discipline at his craft.


text:
Vanderbilt dropped its second straight game with a 65-59 road loss to South Carolina Thursday at Colonial Life Arena.
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Vanderbilt to hold flood-relief drive to support South Carolina
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Miles Looks Ahead to South Carolina
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With more than 15,000 graduates, the College of Fine, Performing and Communication Arts has a vast alumni base. Many of our alumni have gone on to extraordinary achievements within their chosen fields. Some of our recognizable alums and former students are actors Jeffrey Tambor (The Larry Sanders Show, Arrested Development), S. Epatha Merkerson (Law & Order), Ruben Santiago-Hudson (Tony award for Seven Guitars, TV's Castle) and Lily Tomlin (The West Wing, Murphy Brown). Other alumni include radio host Casey Kasem, Pulitzer Prize winning reporter Mark Fritz, Emmy Award-winning composer Joseph LoDuca, opera singer George Shirley, jazz guitarist Kenny Burrell, choreographer Garth Fagan (Tony Award for The Lion King), master ceramist John Glick, illustrator and cartoonist David Small and sculptors David Barr and Sergio DeGiusti.
Join us as we explore The Business of Art:
To delve into the intersection of business and entrepreneurship in art, CFPCA created The Business of Art, a series of symposia geared toward alumni but open to students and the community. Visit The Business of Art's home page often for information about upcoming events and resources available to alums. If you have questions about The Business of Art, please contact CFPCA's Alumni Officer Rhonda Welsh at firstname.lastname@example.com or 313.577.1087.
Expressions is CFPCA's annual alumni magazine.
CFPCA Alumni Association
The CFPCA Alumni Association is an active group dedicated to engaging alumni and growing support for the college in the community. Activities have included volunteer effort, financial underwriting and direct participation. And, as always, the association's board supports the strategic goals and initiatives of the college's faculty and staff. Board of Directors: Anthony Armor '80; F. Victoria Bell '01; LaVette Benson '06, '12; Ted Canaday '96; Darryl Davis '11; Alonso del Arte '09; Althanie Gardner '02, '08, '11, '12; David McDonald '73, '90; Diane Pawlowski, current student; Lisa Marie Rodriguez '06, '12; Constance Thomas '12; Christine Welch '67, '91.
You might also be interested to check out the CFPCA alumni group on LinkedIn. And please support the college as we aspire to new heights in our teaching, learning, research and creative endeavors!


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Big Brothers Big Sisters hosting golf outing to raise awareness
In a world where negativity, violence and pain are never hard to find, a child is a thing of innocence. Simple, unassuming, beautiful innocence.
But sometimes that innocence is corrupted by neglect or malice or spite. Sometimes it is intentional and sometimes it is accidental. Sometimes it is merely circumstance.


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Fedoras are a great hat-style for summer because they shield the sun and boost that SPF (Style Per Fashionista!) quotient! Fedoras can be casual while adding that something extra to an outfit. Look for straw and bright colors for fedoras to pop.
Where to Find Fedoras (Sponsored):
Onigo Imports
Foldable Fedora In Ten Colors
Physician Endorsed
Fedora w/ UPF 50+
David & Young
Basic paper braid fedora w/ black grosgrain band
Hat Attack
Fedora in turquoise raffia
Eric Javits
Fedora wUPF 50+ sun protection
Via Baccio by Memar Srl
Real panama Sunflower summer fedora
Scala Pronto
Fedora w/ faux leather & turquoise
For commercial purposes, extract supplements can be obtained from the fruit of the pericarp. Garcinia cambogia reviews is performed by a physician Chen and Oz to prove that it is an herb for weight loss, a lot of research has been done. Studies, Garcinia cambogia extract supplementation decreases the weight of the body fat accumulation, was shown to have a positive effect on prevention. We are important substances such as cholesterol (LDL), reduces the serum leptin and triglycerides. In addition, it will increase the level of serotonin and cholesterol (HDL). The study also, Garcinia cambogia extract supplements, has proven that there are no significant adverse effects on many of the eight weeks, such as its use.


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Discover a selection of top forums cosmetics wal-mart on the internet. Come to share your passion on forums cosmetics wal-mart and meet other fans of cosmetics wal-mart. Then, why don't you create your own forum of cosmetics wal-mart ?
Find out what product is good and what product is good. Post your techniques to share to others.
makeup, #cosmetics, m.a.c, collections, cosmetic, news, make, lipstick, eyeliner, eyeshadow, shimmer, nails, nail, polish


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A correction has been published | View article
With all the anti-this and anti-that we find about us, it's not surprising that some antiemetic crept into QUESTIONS AND ANSWERS (205:317 [July 29]). The cool ones would have recognized that, in the second question, the third word in the title should have been "Emetics," not "Antiemetics." Let's hope that come winter, the only "anti's" we have to deal with will be "Auntie Mame" and antifreeze.
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"The design and quality of this card is AMAZING. Hats off for the extraordinarily fast and simple purchasing and customising of this product. Will definitely use again!"
"We used these to go with the matching 'Tree Tale' invitations we bought. I loved them, they went perfectly with the invites and I adored the tree detail on the back. Thank you Wedding Paper Divas!"
"I have ordered everything through wedding paper divas and i love the quality, the speed, the designs...my only issue was the order for mini inserts was incomplete. I did not have time to call back as i had to send the invitations so three invitations went out without the insert."
"On whole the invitation came to me looking beautiful and I have compliments on how the general appearance. When I called up customer service with inquiries they were most helpful and very knowledgeable with the product. I received all parts of the invitation in a timely fashion, and the designers did a wonderful job with the special request I made for design changes."
"I needed a card that could guide my guests to the reception from the church because they would need to go down private streets and this card was perfect to slide in with the invitations."


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Hotel Sirio
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- Concierge desk
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- High-speed internet in room (free)
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Top of the town and pool noodles
We got up early, to beat the heat, and walked to a local park and checked out the local spas. A lot is offered here for water treatment therapies. And we all booked massages and other treatments for tomorrow. Then we headed up on the quaint rail car ( Funicolare) and got some lovely pictures high above the city and looked through the tiny village up top. Then we rode back down and bought some lunch to enjoy in our lounge and then spent the rest of the afternoon floating ...
Italian Spring Break - Cinque Terre
Cinque Terre translates to the 5 lands. It gets this name because of the 5 villages that are located here. The whole area is now a protected national park and are UNESCO World Heritage sights. Each of the 5 villages has its own look, feel, and history. They are all connected by hiking trails along the coastline, making it a great place to get out into nature and hike. Also, since they are located on the Mediterranean, life on the sea plays a big role in this area as well. ...
The cinque terre
... pants and an impossibly bright top. She is also 20db louder than any other tourist, especially when complaining. We escaped and spent an hour in the water (including a moment with a jellyfish bite) before walking two hours to vernazza. The walk down into the village gave a stunning view. Well worth the walk (and the 20 euro walk fee.....(who tolls a bush walk ??)) We dropped into a few more villages before sneaking onto the last ferry home . We might have to return on the train ...
First hike in Cinque Terre - fabulous!
... the tessellated vineyards our apartment faces. Not only are the views amazing but so too are the gardens carefully tendered by locals. We see plots for lettuce etc…, tomatoes, zucchini, pumpkin, fruit trees, olive trees and herb gardens. All space is well utilised – as is the case throughout Italy.
Our walk took us around to Ponto Bonfiglio where there is a great children's park with ...
Italy - Cinque Terre
... and everyone was rushing around outside collecting signs etc that were blowing away. We decided to put our jackets on and go to see the sea. It actually wasn't too rough, but very different from the calm picturesque look of the day before! We didn't let this stop us, we headed out to the town next to us (Manarolla) and got some lunch. Amazing bruschetta. It then got really hot. The weather here is nuts, it changes so quickly! We then headed to the middle village, Corniglia. This ...


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Electromyography in Clinical Practice
A Case Study Approach
- Bashar Katirji, MD, FACP, Director, Neuromuscular Center & EMG laboratory; The Neurological Institute, University Hospitals Case Medical Center, Professor of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio
- Bashar Katirji, MD, FACP, Director, Neuromuscular Center & EMG laboratory; The Neurological Institute, University Hospitals Case Medical Center, Professor of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio
The only case-based guide to electromyography—back in a fully revised and updated New Edition! This practical resource examines how to approach, diagnose, and manage the most commonly encoun-tered disorders in the EMG laboratory. Based on actual cases, it correlates patient history, physical exam, EMG findings, relevant anatomy, treatment, and follow-up to help readers sharpen their clinical problem-solving skills. New cases have been added, and every case includes the latest advances in knowledge and technique.View full description
Neurologists, Physiatrists, Clinical Neurophysiologists, Physical Medicine and Rehabilitation
Book information
- Published: August 2007
- Imprint: MOSBY
Table of ContentsIntroduction to Clinical Electromyography
Nerve Conduction Studies
Needle EMG Examination
Specialized Procedures
Overview of Electromyography Laboratory Procedures and Reporting
Case Studies
Focal Disorders
Case 1: Nerve Injury
Case 2: Ischemic Monomelic Neuropathy
Case 3: Tourniquet Paralysis
Focal Disorders of the Lower Extremity
Case 4: Lumbosacral Radiculopathy
Case 5: Sciatic Neuropathy
Case 6: Femoral Neuropathy
Case 7: Lumbosacral Plexopathy
Case 8: Tarsal Tunnel Syndrome
Case 9: Diabetic Amyotrophy
Case 10: Peroneal Neuropathy
Focal Disorders of the Upper Extremity
Case 11: Ulnar Neuropathy at the Wrist
Case 12: Axillary Neuropathy
Case 13: Cervical Radiculopathy
Case 14: Radial Neuropathy
Case 15: Thoracic Outlet Syndrome
Case 16: Carpal Tunnel Syndrome
Case 17: Ulnar Neuropathy at the Elbow
Case 18: Neuralgia Amyotrophy (Acute Brachial Plexitis)
Generalized Disorders
Case 19: Myasthenia Gravis
Case 20: Chronic Inflammatory Demyelinating Polyneuropathy
Case 21: Amyotrophic Lateral Sclerosis
Case 22: Diabetic Peripheral Polyneuropathy
Case 23: Polymyositis
Case 24: Mononeuropathy Multiplex
Case 25: Lambert-Eaton Syndrome
Case 26: Charcot-Marie-Tooth Disease
Case 27: Myotonic Dystrophy
Case 28: Dorsal Ganglionopathy (Sensory Neuronopathy)
Case 29: Guillian-Barre Syndrome
Case 30: Botulism
Case 31: Hereditary Neuropathy with Liability to Pressure Palsy
Case 32: Multifocal Motor Neuropathy


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We regret that due to the technical limitations of our site, we are unable to offer eBooks or Audio Downloads to customers outside of the UK.
For further details please read our eBooks help.
Accounting: A Smart Approach (Paperback)Mary Carey, Cathy Knowles, Jane Towers-Clark
Paperback Published: 20/01/2011
- Not in our warehouse
Check availability At your local shop
Are you looking for a fresh, innovative approach to accounting that will engage your students and truly bring the subject to life? Then meet Sam Smart. In chapter one we meet Sam as he is setting up his own business and looking at the financial information needed when starting to trade. We then follow him through the textbook as the business grows to a multinational manufacturing and retailing company. We learn with Sam how to assess the success of his business, finance day to day activities, make pricing decisions, invest in product launches and new distribution channels, and control an expanding business. Developed specifically with non-specialist students in mind, and tested and reviewed by business students, this is the perfect textbook for your introductory accounting module. Covering all the core topics found on a typical introductory accounting module, this fully integrated case study will give students the confidence they need to successfully approach their course and exams. Combined with the wealth of additional examples and self-test exercises available, students will not only develop an appreciation of how accounting information allows a manager to make key business decisions, but they will also acquire the skills necessary to enable them to converse with accountants, and challenge their assumptions and methodologies. Through the provision of integrated PowerPoint slides, a comprehensive question pack and a detailed assessment guide, lecturers are provided with a comprehensive and reliable package of support, which is vital when teaching large student cohorts. An Online Resource Centre accompanies the textbook and includes: For Students: Additional questions and exercises (including questions covering higher level material) Flashcard glossary of key terms from the book For Lecturers: Fully integrated and customisable PowerPoint slides Question pack plus solutions Assessment guide
Publisher: Oxford University Press


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Just started climbing again after a ten year layoff. Had my first experiences at indoor wall climbing (I forgot how much getting fit hurts)
Have been to Stannage and Burbage South but just did a bit of bouldering to get back into it.
My missus has done a belay course so look forward to doing some serious stuff soon.
Best Climbing Experience
Getting halfway up the Eiger many years ago, but had to turn back due to weather. Bummer.
Favourite Climbing-Related Discussion Topic
Recent Postings
- No posts in last 30 days
Interests Outside Climbing
Motorcycle racing, (watching only nowadays), camping ,hiking, photography.
About My Photography
Hope to post some soon. Ranges from rock to winter moutaineering.
Photo Gallery
Click to view Scally's gallery. (22 photos)
Click to search for photos of climbers called Scally.
Click to list photo comments written by me. (10 comments)
Anything Else We Should Know
Would like to hear from anyone in my area who would like to hook up to do some climbing locally, up to HVS at the moment.


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Research Article
Spillover Effects of Voluntary Environmental Programs on Greenhouse Gas Emissions: Lessons from Mexico
Article first published online: 11 DEC 2012
DOI: 10.1002/pam.21675
© 2012 by the Association for Public Policy Analysis and Management
Journal of Policy Analysis and Management
Volume 32, Issue 2, pages 296–322, Spring 2013
Additional Information
How to Cite
Henriques, I., Husted, B. W. and Montiel, I. (2013), Spillover Effects of Voluntary Environmental Programs on Greenhouse Gas Emissions: Lessons from Mexico. J. Pol. Anal. Manage., 32: 296–322. doi: 10.1002/pam.21675
Publication History
- Issue published online: 19 MAR 2013
- Article first published online: 11 DEC 2012
- Abstract
- Article
- References
- Cited By
We compare the environmental performance of voluntary environmental programs (VEPs) with different attributes. Using club theory, we argue that the differential performance of VEPs is due in part to their specific design attributes that will either enhance or diminish their ability to improve both targeted and untargeted environmental impacts. We analyze two VEPs in Mexico, the global standard ISO 14001 and the local standard Clean Industry. These two VEPs differ in the stringency of the standards and in their ability to sanction noncompliant facilities. These differences ensure that firms adopting the local standard are less likely to shirk their responsibilities and enhance potential spillover effects on untargeted environmental emissions. Our empirical results support our hypotheses and show that the local Clean Industry program is more effective in improving both targeted (toxic emissions) and untargeted environmental impacts (greenhouse gas emissions).


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3Ms Water Temperature and Wetsuit Guide
(Baja Norte, Mexico)
Today's 3Ms sea temperature is 20.9 °C.
Statistics for 09 Oct (1981–2005) – mean: 19.7 °C, range: 18.8 °C to 21.1 °C
…Overall: 3.4
Based on 9 votes. Vote
Today's 3Ms sea temperature is 20.9 °C.
Statistics for 09 Oct (1981–2005) – mean: 19.7 °C, range: 18.8 °C to 21.1 °C
A hot sunny day, feeling like 34 °C even after we account for wind, and warm water temperature (20 °C) too at 3Ms. Surfers may need a thin summer wetsuit or at least a rash vest to block the UV. Otherwise, warm enough for just board shorts.
(click thumbnails to expand)
Below is a graph of Historical Sea Surface Temperature for 3Ms. This has been derived from analysis of two decades of oceanographic satellite measurements of nearby open water. We have calculated the average water temperature variation around the year as well as the extremes that have been observed on each date.
All of the graphs for the surf breaks presented on Surf-Forecast.com are on the same scale to enable comparison between locations around the world.
3Ms water temperatures peak in the range 19 to 23°C (66 to 73°F) on around the 7th of September and are at their coldest on about the 3rd of February, in the range 14 to 17°C (57 to 63°F). 3Ms water temperatures are maximum in the first part of September. Surfers should use a 2mm long sleeve shorty or a 3/2mm spring wetsuit if the wind is up. The coldest seasonal water temperatures at 3Ms at the start of February lend themselves to a 4/3mm wetsuit or a 3/2mm suit and 3mm neoprene boots.
Actual sea surface water temperatures close to shore at 3Ms can vary by several degrees compared with these open water averages. This is especially true after heavy rain, close to river mouths or after long periods of strong offshore winds. Offshore winds cause colder deep water to replace surface water that has been warmed by the sun. Air temperature, wind-chill and sunshine should also be considered before deciding on the kind of wetsuit needed to stay warm when surfing at 3Ms. Refer to our detailed weather forecasts for this information.


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Dr. Jonathan S. Jaivin graduated from the University of Connecticut School of Medicine in 1985. He works in Valencia, CA and 1 other location and specializes in Orthopaedic Surgery. Dr. Jaivin is affiliated with Los Robles Hospital & Medical Center, Motion Picture & Television Fund-The Wasserman Campus, Northridge Hospital Medical Center, Simi Valley Hospital and Valley Presbyterian Hospital.
Orthopaedic Surgery
Medical School: University of Connecticut School of Medicine; Graduated 1985
*This physician has multiple office locations. See Office Information for details.
25751 McBean Pkwy Ste 215
Valencia, CA 91355
23734 Valencia Blvd Ste 203
Valencia, CA 91355
23803 McBean Pkwy Ste 101
Valencia, CA 91355
23861 McBean Pkwy Ste E30
Valencia, CA 91355
110 Jensen Ct Ste 2A
Thousand Oaks, CA 91360


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Fri, Aug. 7, 4:53 PM
- Ford (NYSE:F) has hired Tower International (NYSE:TOWR) as a second supplier to provide steel frames for its best-selling F-150 truck, hoping to better meet delivery demands amid a parts shortage from its current supplier, WSJ reports.
- Ford is struggling to get as many F-150s on dealer lots as originally planned because its supplier, Mexico-based Metalsa, is having trouble building enough frames to keep pace with production needs, according to the report.
- Meanwhile, Ford is said to be shipping frames to its factories by truck rather than rail to get them there faster but at a higher cost.
Thu, Jul. 30, 7:07 AM
- Tower (NYSE:TOWR): Q2 EPS of $1.05 beats by $0.06.
- Revenue of $490.27M (-10.6% Y/Y) misses by $7.75M.
- Press Release
Mon, Jun. 29, 10:38 AM
- Select auto supplier stocks are feeling the sharpest pinch in the consumer goods sector from the developments in Greece.
- Westport Innovations (WPRT -4.6%), Delphi Automotive (DLPH -3.3%), and Tower International (TOWR -1.8%) are all trading weaker than broad averages.
- Goodyear Tire & Rubber (GT -3.4%) and Cooper Tire & Rubber (CTB -1.8%) are also feeling pressure.
Wed, Jun. 10, 11:03 AM
- A good part of the automobile supplier sector is ahead of broad market averages with M&A buzz in the background.
- Though Fiat Chrysler Automobiles CEO Sergio Marchionne has been making quite a bit of noise on the need for major automakers to consolidate, analysts think it's the suppliers with the most to gain from strategic mergers with next-gen vehicles going in different directions.
- Gainers: Lear (NYSE:LEA) +2.0%, Motorcar Parts of America (NASDAQ:MPAA), Cooper-Standard (NYSE:CPS) +2.4%, Strattec Security (NASDAQ:STRT) +1.4%, Gentherm (NASDAQ:THRM) +3.0%, Magna International (NYSE:MGA) +1.7%, American Axle & Manufacturing (NYSE:AXL) +1.5%, Tower International (NYSE:TOWR) +1.5%, Standard Motor Products (NYSE:SMP) +2.2%.
- Previously: Lennox International higher on report of Johnson Controls interest (Jun. 10 2015)
- Previously: Johnson Controls +6% after announcing strategic review (Jun. 10 2015)
Thu, May 7, 10:19 AM
- Tower International (TOWR +9.2%) rallies after blasting past Q1 profit estimates.
- Organic sales were up 4% during the quarter.
- Tower tightened up on SG&A expenses to help achieve the EPS beat.
- The company lowered its full-year revenue guidance by $50M to $1.95B to reflect new foreign currency expectations.
- Previously: Tower beats by $0.21, misses on revenue
Thu, May 7, 7:50 AM
- Tower (NYSE:TOWR): Q1 EPS of $0.82 beats by $0.21.
- Revenue of $496.63M (-4.4% Y/Y) misses by $12.38M.
- Press Release
Fri, Apr. 10, 5:36 PM
Thu, Feb. 12, 7:51 AM
- Tower (NYSE:TOWR): Q4 EPS of $0.84 beats by $0.12.
- Revenue of $502.3M (+4.5% Y/Y)
- Press Release
Dec. 19, 2014, 5:58 PM
- Consumer spending in several areas is likely to benefit from lower pump prices, but J.P. Morgan's Ryan Brinkman thinks the auto industry may benefit more than most from consumers having more money to spend on all things apart from fuel.
- The analyst sees Goodyear Tire (NASDAQ:GT), American Axle (NYSE:AXL), GM and Ford (NYSE:F) - in that order - as best positioned to benefit, followed by suppliers with material exposure to full-size trucks and SUVs that is not as great as AXL, including Tenneco (NYSE:TEN), Lear (NYSE:LEA) and Tower International (NYSE:TOWR).
- Tesla (NASDAQ:TSLA) is an exception, however, as Brinkman sees a potential reduction in the terminal value of cash flows on his reduced outlook for Model 3 vehicles if fuel prices remain low longer-term.
Oct. 30, 2014, 8:06 AM
- Tower (NYSE:TOWR): Q3 EPS of $0.73 beats by $0.16.
- Revenue of $523M (+5.6% Y/Y) misses by $1.48M.
- Press Release
Oct. 17, 2014, 5:40 PM
Jul. 31, 2014, 8:33 AM
- Tower (NYSE:TOWR): Q2 EPS of $0.93 beats by $0.12.
- Revenue of $576.56M (+3.7% Y/Y) beats by $4.73M.
- Press Release
Feb. 13, 2014, 7:14 AM
- Tower International, Inc. (TOWR): Q4 EPS of $0.45 beats by $0.02.
- Revenue of $517M (+1.8% Y/Y) in-line.
- Press Release
Nov. 1, 2013, 9:13 AM
Oct. 30, 2013, 8:36 AM| Oct. 30, 2013, 8:36 AM | Comment!
Jul. 22, 2013, 12:45 PM
TOWR vs. ETF Alternatives
Company Description
Tower International Inc is a manufacturer of engineered automotive structural metal components and assemblies. It offers body-structure stampings, frame and other chassis structures, and complex welded assemblies for small and large cars.
Sector: Industrial Goods
Industry: Metal Fabrication
Country: United States
Other News & PR
See More »


text:
Hotel Palace Club
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Intrepid Boho Travellers Guide ‐Teplice Nad
... a beer or two. What we actually discovered was that there was ************e there (we saw in total about 20 people), noone spoke any English / but on the plus side camping was super cheap. There are a few guesthouses dotted around but couldn't see a hostel at all / anyway camping is more fun. Now when I say camping Im obviously not carrying a tent around for the next year or so but with a bit of pre‐planning you can ...
... br>
Sadly the Royal Palace was closed so we visited the Rosenberg Palace instead. This was apparently a centre for Distressed Noblewomen (read "poor spinsters") that was established by the Austrian Empress Marie Therese when Prague was part of the Austro-Hungarian Empire. We also saw the St George Basilica and walked along the Golden Lane – which has undergone some major renovation since 2008 and was much better. There were still lots of ...
Travel to Teplice Nad Metují
... viewing platform, by the time we got near the top it became more like climbing a ladder than walking up steps. We got a nice view from up there but didn't hang around to take it in for long because almost as soon as we reached the top it started pouring with rain! We looked like drowned rats by the time we got back to our accommodation & really appreciated a warm shower before dinner, all part of the ...
Lalalalala weddings weddings weddings!
I don't want to do this but I guess I have to write my last entry until next summer when I travel all across the U.S.A. Oh did I just say that I wasn't suppose to tell well now you have a head start on the next blog. Good bye everypony oops my little brother has been watching to many My Little Pony videos. Well the wedding went well, we were dancing all night and taking (lots) of pictures. I got to see my long lost cousins, Camy and ...
A whistfully wonderful wedding
... to celebrate Daria and Ghislain's wedding was one of those special times that we only experience a few times in our lives. The last time we had seen many of our counsins and family was well over 6 years ago. Isabella was Lukas' age the last time she saw two of her big cousins, Camy and Sydney, who Isabella remembered so fondly. There were also many new additions to the family since the last time we met. How fun it was just to spend time in such a celebratory manner ...


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Apple Donuts with IZZE Sparkling Apple Juice
What's for breakfast? How about these fall favorite apple juice donuts?
What a gorgeous day it has been in Portland. It was 74 today! And sunny! My little plants are all popping up. The lettuce is in the ground outside and I swear it grew visibly larger in the last 24 hours with all that sun. The rhubarb is very nearly ready for go time (HELLO, PIE.) And my tomato starts inside are looking pretty good (knock on wood). I will be hovering over them on a daily basis until I can pick the tomatoes off of them. As usual.
I love having gardening and yard work be back in our weekend routine. Dave cuts the grass, I plant more and more things, and I hover over all of the plants, one after the other. I can't wait to have summer fruits and vegetables to cook with, but until then, I've still got some bananas in my freezer.
If you thought we had exhausted the possibilities of chocolate-banana breakfast combinations, you thought wrong, my friends. Bam:
And I think these chocolate banana swirl muffins might be my favorite of our chocolate banana concoctions thus far. Which is saying something.
Here's what you need:
3/4 cup brown sugar
1/4 cup vegetable oil
1/4 cup milk
1 egg
1/2 tsp. vanilla
2 cups AP flour
1/4 tsp. baking soda
1 tsp. baking powder
1/4 tsp. salt
6 Tbsp. sour cream
2 bananas, mashed
3 oz. chocolate chips
2 tsp. cream
Preheat the oven to 350 degrees. Grease a muffin tin with butter or nonstick cooking spray.
In a mixing bowl, stir together the brown sugar, oil, milk, egg, sour cream and vanilla using a whisk. Smash the bananas and whisk into the liquids.
In a separate bowl, stir together the flour, baking soda, baking powder and salt. Add the solids to the liquids and fold them together with as few strokes as possible.
Remove about a half cup of the batter, and divide the rest between the muffin tins.
In a glass bowl, stir together the chocolate chips and cream. Microwave for 10 seconds at a time, stirring in between, until smooth. Mix this chocolate with the reserved half cup of batter, then divide between the muffin cups and swirl with a spoon or chopstick. Bake for 15-20 minutes.
Beautifully baked muffins.. yummy!!
Comment by Hari Chandana — April 7, 2014 @ 11:55 pm
Those look to die for!! Might even be good with some Nutella!
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What's for breakfast? How about these fall favorite apple juice donuts?
As much as I love baking for breakfast, on some of these summer mornings where you can already feel the heat coming at 8 a.m., a smoothie is in order.
Migas are always a favorite of mine. And thankfully the mornings have been cool enough to cook in (though our break in the heat wave is coming soon!)


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nginx [engine x] is a HTTP server and mail proxy server written by Igor Sysoev.
Supercharged web hosting service.
DNS services provided by CloudFlare.
WordPress is a state-of-the-art semantic personal publishing platform with a focus on aesthetics, web standards, and usability.
PHP is a widely-used general-purpose scripting language that is especially suited for Web development and can be embedded into HTML.
Tells owners of The website how many people are visiting the site, where they are coming from and whats most interesting to them.
sIFR replacement cufon with simpler and easier to use functionality. Shows fonts in a nice format.
JQuery is a fast, concise, JavaScript Library that simplifies how you traverse HTML documents, handle events, perform animations, and add Ajax interactions to your web pages. jQuery is designed to change the way that you write JavaScript.
CSS Browser selector hack.
hoverIntent is a plug-in that attempts to determine the user's intent. It works like (and was derived from) jQuery's built-in hover. However, instead of immediately calling the onMouseOver function, it waits until the user's mouse slows down enough before making the call.
Superfish is an enhanced Suckerfish-style menu jQuery plugin that takes an existing pure CSS drop-down menus and adds much-sought-after enhancements.
The page embeds the Twitter platform in one method or another.
Replaces older and newer page links with different ones.
Automatically optimizes the delivery of your web pages so your visitors get the fastest page load times and best performance.
FeedBurner is the leading provider of media distribution and audience engagement services for blogs and RSS feeds.
The website claims XHTML strict. XHTML Strict is the same as HTML 4.01 Strict but follows XML guidelines. See the link for more information.
The description attribute provides a concise explanation of the page content.
This page contains a meta robots tag which tells search engines and robots to index or not index the page.
Cascading Style Sheets (CSS) is a stylesheet language used to describe the presentation of a document written in a markup language. Its most common application is to style web pages written in HTML
The website uses conditional comments that are supported by Microsoft Internet Explorer. They allow web developers to show or hide HTML code based on the version of the viewer's browser.
JavaScript is a scripting language most often used for client-side web development. Its proper name is ECMAScript, though "JavaScript" is much more commonly used. The website uses JavaScript.
This page may be using a 960 grid layout system from 960.gs.
UTF-8 (8-bit UCS/Unicode Transformation Format) is a variable-length character encoding for Unicode. It is the preferred encoding for web pages.
Last updated 10th September.
We know of 27 active technologies on this page and 9 technologies removed
from london-seo.com since 3rd March 2012. Link to this page.
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