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Publications (24)112.07 Total impact
- Molecular Cancer Research 12/2014; 12(12 Supplement):A35-A35. DOI:10.1158/1557-3125.RASONC14-A35 · 4.38 Impact Factor
Article: Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei[Show abstract] [Hide abstract]
ABSTRACT: Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 μg/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure-activity relationship of the pyrrolobenzoxaboroles are also discussed.European Journal of Medicinal Chemistry 04/2014; 81C:59-75. DOI:10.1016/j.ejmech.2014.04.079 · 3.45 Impact Factor
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ABSTRACT: Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics.International Journal of Molecular Sciences 01/2014; 15(1):1358-73. DOI:10.3390/ijms15011358 · 2.86 Impact Factor
Article: Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei[Show abstract] [Hide abstract]
ABSTRACT: A new class of benzoxaboroles were synthesized as antitrypanosomal agents and showed IC50 as low as 0.03 μg/mL. Three of the lead compounds eliminated parasitic infection in a murine model.
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ABSTRACT: Benzoxaborole, as a versatile scaffold, plays important roles in organic synthesis, molecular recognition and supramolecular chemistry. It is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like properties. Recently, benzoxaboroles were widely applied as antifungal, antibacterial, antiviral, anti-parasite, and anti-inflammatory agents. This review covers the properties, synthetic methods and applications of benzoxaboroles in medicinal chemistry. © 2013 Science China Press and Springer-Verlag Berlin Heidelberg.Science China-Chemistry 10/2013; 56(10):1372-1381. DOI:10.1007/s11426-013-4981-y · 1.70 Impact Factor
Article: Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors[Show abstract] [Hide abstract]
ABSTRACT: Human African trypanosomiasis (HAT) is one of the most neglected diseases in the tropic regions, which is fatal if not treated in time. There is an urgent need for new therapeutics, especially those in new chemical classes. Leucyl-tRNA synthetase (LeuRS) has been paid much attention as a recently clinically validated antimicrobial target. Our group has previously reported T. brucei LeuRS (TbLeuRS) inhibitors, including benzoxaboroles targeting the editing site and pyrrolinones targeting the synthetic site. Here we report the discovery of N-(4-sulfamoylphenyl)thioureas as a new class of TbLeuRS inhibitors. The R(1) and R(2) groups, reminiscent of the leucyl and adenyl regions of aa-AMP and aa-AMS, were optimized to result in a significant 13-fold increase of inhibitory activity (compound , IC50 = 13.7 μM). Aided by ligand-protein docking, the 1,3-substitution at the central phenyl ring was predicted and proved to give significantly improved activity (, IC50 = 1.1 μM). This work provided a new scaffold for the exploration of novel inhibitors against TbLeuRS, which may become potential therapeutics for the treatment of HAT.Organic & Biomolecular Chemistry 07/2013; 11(32). DOI:10.1039/c3ob40236c · 3.56 Impact Factor
Article: Small Molecule Targeting Cdc42-Intersectin Interaction Disrupts Golgi Organization and Suppresses Cell Motility[Show abstract] [Hide abstract]
ABSTRACT: Signaling through the Rho family of small GTPases has been intensely investigated for its crucial roles in a wide variety of human diseases. Although RhoA and Rac1 signaling pathways are frequently exploited with the aid of effective small molecule modulators, studies of the Cdc42 subclass have lagged because of a lack of such means. We have applied high-throughput in silico screening and identified compounds that are able to fit into the surface groove of Cdc42, which is critical for guanine nucleotide exchange factor binding. Based on the interaction between Cdc42 and intersectin (ITSN), a specific Cdc42 guanine nucleotide exchange factor, we discovered compounds that rendered ITSN-like interactions in the binding pocket. By using in vitro binding and imaging as well as biochemical and cell-based assays, we demonstrated that ZCL278 has emerged as a selective Cdc42 small molecule modulator that directly binds to Cdc42 and inhibits its functions. In Swiss 3T3 fibroblast cultures, ZCL278 abolished microspike formation and disrupted GM130-docked Golgi structures, two of the most prominent Cdc42-mediated subcellular events. ZCL278 reduces the perinuclear accumulation of active Cdc42 in contrast to NSC23766, a selective Rac inhibitor. ZCL278 suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer cell line (i.e., PC-3) without disrupting cell viability. Thus, ZCL278 is a small molecule that specifically targets Cdc42-ITSN interaction and inhibits Cdc42-mediated cellular processes, thus providing a powerful tool for research of Cdc42 subclass of Rho GTPases in human pathogenesis, such as those of cancer and neurological disorders.Proceedings of the National Academy of Sciences 01/2013; 110(4). DOI:10.1073/pnas.1116051110 · 9.67 Impact Factor
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ABSTRACT: The bonding characteristics in cysteine-gold cluster complexes represented by thiolate (Au(n)·Cys(S) (n = 1, 3, 5, 7)) and thiol (Au(n)·Cys(SH) (n = 2, 4, 6, 8)) is investigated by density functional theory with 6-31G(d,p) and Lanl2DZ hybrid basis sets. The complexes exhibit very different bonding characteristic between these two forms. In the Au(n)·Cys(S) complexes, the charge transfers from gold clusters to sulfur atoms. The number of S-Au bonds in the Au(n)·Cys(S) complexes evolves from one to two when n is greater than three. For n equals three, i.e. Au(3)·Cys(S), its ground state only has one S-Au bond. While the only S-Au bond in Au(1)·Cys(S) is mainly covalent, the nature of the S-Au bond in other thiolates is featured with the combination of covalent and donor-acceptor interactions. In particular, one stable isomer of Au(3)·Cys(S) with two S-Au bonds, which is 2 kcal mol(-1) higher in energy than the corresponding ground state, consists of one covalent and one donor-acceptor S-Au bond explicitly. Moreover, the localized three center two electron bonds are formed within the Au clusters, which facilitates the formation of the two S-Au bonds in Au(5)·Cys(S) and Au(7)·Cys(S) complexes. In the Au(n)·Cys(SH) complexes, the donor-acceptor interaction prevails in the Au-SH bond by transferring lone pair electrons from the sulfur atom to the adjacent gold atom. Interestingly, the orbital with much more 6s-component in Au(4)·Cys(SH) enhances the donor-acceptor bonding character, thus yields the strongest bonding among all the Au(n)·Cys(SH) complexes studied in this paper. In general, the bonding strength between gold clusters and cysteine is positively correlated with the S-Au overlap-weighted bond order, but negatively correlated with the S-Au bond length. Lastly, the covalent and donor-acceptor S-Au bond strength is computed to be 48 and 18 kcal mol(-1), respectively.Physical Chemistry Chemical Physics 12/2012; 15(5). DOI:10.1039/c2cp42830j · 4.49 Impact Factor
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ABSTRACT: Among the regulation mechanisms of cellular function, allosteric regulation is the most direct, rapid and efficient. Due to the wider receptor selectivity and lower target-based toxicity, compared with orthosteric ligands, allosteric modulators are expected to play a larger role in pharmaceutical research and development. However, current difficulties, such as a low affinity and unknown structural features of potential allosteric small-molecules, usually obstruct the discovery of allosteric modulators. In this study, we compared known allosteric modulators with various compounds from different databases to unveil the structural and qualitative characteristics of allosteric modulators. The results show that allosteric modulators generally contain more hydrophobic scaffolds and have a higher structural rigidity, i.e., less rotatable bonds and more rings. Based on this analysis, an empirical rule was defined to determine the structural requirements for an allosteric modulator. It was found that a large proportion of allosteric modulators (80%) can be successfully retrieved by this "allosteric-like" filter, which shows good discriminatory power in identifying allosteric modulators. Therefore, the study provides deeper insight into the chemical properties of allosteric modulators and has a good potential for the design or optimization of allosteric compounds.Journal of molecular graphics & modelling 08/2012; 38C:324-333. DOI:10.1016/j.jmgm.2012.07.006 · 1.72 Impact Factor
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ABSTRACT: We report the novel chalcone-benzoxaborole hybrids and their structure-activity relationship against Trypanosoma brucei parasites. The 4-NH(2) derivative 29 and 3-OMe derivative 43 were found to have excellent potency. The synergistic 4-NH(2)-3-OMe compound 49 showed an IC(50) of 0.010 μg/mL and resulted in 100% survival and zero parasitemia in a murine infection model, which represents one of the most potent compounds discovered to date from the benzoxaborole class that inhibit T. brucei growth.Journal of Medicinal Chemistry 02/2012; 55(7):3553-7. DOI:10.1021/jm2012408 · 5.45 Impact Factor
Article: Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles[Show abstract] [Hide abstract]
ABSTRACT: A series of new boron-containing benzoxaborole compounds was designed and synthesized for a continuing structure-activity relationship (SAR) investigation to assess the antimalarial activity changes derived from side-chain structural variation, substituent modification on the benzene ring and removal of boron from five-membered oxaborole ring. This SAR study demonstrated that boron is required for the antimalarial activity, and discovered that three fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 14 and 20) have excellent potencies (IC(50) 0.026-0.209 μM) against Plasmodium falciparum.Bioorganic & medicinal chemistry letters 02/2012; 22(3):1299-307. DOI:10.1016/j.bmcl.2011.12.096 · 2.42 Impact Factor
Article: Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis[Show abstract] [Hide abstract]
ABSTRACT: Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei, is a neglected fatal disease. Leucyl-tRNA synthetase (LeuRS), which has been successfully applied in the development of antifungal agent, represents a potential antiprotozoal drug target. In this study, a 3D model of T. brucei LeuRS (TbLeuRS) synthetic active site was constructed and subjected to virtual screening using a combination of pharmacophore- and docking-based methods. A new 2-pyrrolinone scaffold was discovered and the structure-activity relationship (SAR) studies aided by the docking model and organic synthesis were carried out. Compounds with various substituents on R(1), R(2) and R(3) were synthesized and their SAR was discussed.Bioorganic & medicinal chemistry 02/2012; 20(3):1240-50. DOI:10.1016/j.bmc.2011.12.035 · 2.79 Impact Factor
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ABSTRACT: The synthesis and characterization of highly challenging 2,3,6-trideoxy sugar nucleotides were described for the first time. The study of their hydrolysis kinetics in aqueous buffers provided insight into their application as glycosyl donors.Tetrahedron Letters 11/2011; 52(44):5799-5801. DOI:10.1016/j.tetlet.2011.08.132 · 2.38 Impact Factor
Article: Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitor[Show abstract] [Hide abstract]
ABSTRACT: As the best-characterized ubiquitin-like protein (UBL), small ubiquitin-related modifier (SUMO) was found to conjugate with a number of proteins to regulate cellular functions including transcription, signal transduction, and cell cycle. While E1, E2 and E3 ligases are responsible for the forward SUMOylation reaction, SUMO-specific proteases (SENPs) reversibly remove SUMO from the SUMOylated proteins. Recently, SENP1 was found to be a potential therapeutic target for the treatment of prostate cancers, but the design and synthesis of its inhibitors have not been reported. We designed and synthesized a series of benzodiazepine-based SENP1 inhibitors, and they showed inhibitory activity as good as IC(50)=9.2μM (compound 38). The structure-activity relationship was also discussed.Bioorganic & medicinal chemistry letters 09/2011; 21(21):6389-92. DOI:10.1016/j.bmcl.2011.08.101 · 2.42 Impact Factor
Article: Design, Synthesis, and Structure-Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents[Show abstract] [Hide abstract]
ABSTRACT: African trypanosomiasis, caused by the proto zoal pathogen Trypanosoma brucei (T. brucei), is one of the most neglected tropical diseases that are in great need of new drugs. We report the design and synthesis of T. brucei leucyl-tRNA synthetase (TbLeuRS) inhibitors and their structure--activity relationship. Benzoxaborole was used as the core structure and C(6) was modified to achieve improved affinity based on docking results that showed further binding space at this position. Indeed, compounds with C(7) substitutions showed diminished activity due to clash with the eukaryote specific I4ae helix while substitutions at C(6) gave enhanced affinity. TbLeuRS inhibitors with IC(50) as low as 1.6 μM were discovered, and the structure-activity relationship was discussed. The most potent enzyme inhibitors also showed excellent T. brucei parasite growth inhibition activity. This is the first time that TbLeuRS inhibitors are reported, and this study suggests that leucyl-tRNA synthetase (LeuRS) could be a potential target for antiparasitic drug development.Journal of Medicinal Chemistry 02/2011; 54(5):1276-87. DOI:10.1021/jm101225g · 5.45 Impact Factor
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ABSTRACT: We report the discovery of benzoxaborole antitrypanosomal agents and their structure−activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei.Keywords (keywords): Tryapnosoma brucei; African trypanosomiasis; benzoxaboroleACS Medicinal Chemistry Letters 04/2010; 1(4). DOI:10.1021/ml100013s · 3.12 Impact Factor
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ABSTRACT: Despite of the medicinal significance of benzoxaboroles, with the newly discovered clinical compound AN2690 as an example, the synthetic method for rapid diversification of this novel scaffold is lacking. To this end, a versatile and scalable synthesis of formyl-substituted benzoxaboroles is described here. A key step is the mono-oxidation of the two hydroxyls in compound 4 by taking advantage of the stable oxaborole ring in non-coordinating solvents, which was devised based on the study of the intramolecular coordination and exchange properties.Tetrahedron 10/2009; 65(42):8738-8744. DOI:10.1016/j.tet.2009.08.026 · 2.64 Impact Factor
Article: ChemInform Abstract: Discovery and StructureActivity Study of a Novel Benzoxaborole Antiinflammatory Agent (AN2728) for the Potential Topical Treatment of Psoriasis and Atopic Dermatitis[Show abstract] [Hide abstract]
ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.ChemInform 09/2009; 40(36). DOI:10.1002/chin.200936177
Article: ChemInform Abstract: Discovery and Structure—Activity Study of a Novel Benzoxaborole Antiinflammatory Agent (AN2728) for the Potential Topical Treatment of Psoriasis and Atopic Dermatitis[Show abstract] [Hide abstract]
ABSTRACT: A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. This compound is now in clinical development for the topical treatment of psoriasis and being pursued for the topical treatment of atopic dermatitis.Bioorganic & medicinal chemistry letters 05/2009; 19(8):2129-32. DOI:10.1016/j.bmcl.2009.03.007 · 2.42 Impact Factor
Article: Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H[Show abstract] [Hide abstract]
ABSTRACT: A gene cluster (pol) essential for the biosynthesis of polyoxin, a nucleoside antibiotic widely used for the control of phytopathogenic fungi, was cloned from Streptomyces cacaoi. A 46,066-bp region was sequenced, and 20 of 39 of the putative open reading frames were defined as necessary for polyoxin biosynthesis as evidenced by its production in a heterologous host, Streptomyces lividans TK24. The role of PolO and PolA in polyoxin synthesis was demonstrated by in vivo experiments, and their functions were unambiguously characterized as O-carbamoyltransferase and UMP-enolpyruvyltransferase, respectively, by in vitro experiments, which enabled the production of a modified compound differing slightly from that proposed earlier. These studies should provide a solid foundation for the elucidation of the molecular mechanisms for polyoxin biosynthesis, and set the stage for combinatorial biosynthesis using genes encoding different pathways for nucleoside antibiotics.Journal of Biological Chemistry 04/2009; 284(16):10627-10638. DOI:10.1074/jbc.M807534200 · 4.57 Impact Factor
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Shanghai Jiao Tong University
Shanghai, Shanghai Shi, China
- • School of Pharmacy
- • Department of Pharmacy (Sixth People's Hospital)


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Barron's 2014 Roundtable Highlight
The consumer accounts for approximately 70% of the U.S. economy. Consumer net worth was $77.3 trillion at the end of September. Debt has remained constant for five years. Housing values have gone up. Jobs and psychology are improving. Auto sales are flattening, but remain OK. The Wal-Mart shopper isn't doing as well as the Whole Foods shopper, but overall, the consumer is regaining confidence and will spend. Elsewhere in the economy, nonresidential construction is booming. Confidence in the corporate sector was hurt by the government shutdown last fall. Government debt, not the deficit, is the long-term issue. But, on balance, corporations are also regaining confidence. State and local revenues are up, as is spending.....
Another important point: With interest rates up, the stock market rising, plus accounting changes, corporations will put less cash into pension plans. That means corporate cash flow will be much higher than profits in 2014. Corporations' appetite for growth is starting to rise. You'll start to see more corporations forgo share buybacks and dividend increases in favor of doing deals. Companies will look to change their culture or business mix, spending more on research and development, starting greenfield projects, launching takeovers.
|1/10/14 Price
|Journal Communications /JRN
|Diebold dbd 1.5562913907284768% Diebold Inc. U.S.: NYSE USD30.67 0.47 1.5562913907284768% /Date(1443819830019-0500)/ Volume (Delayed 15m) : 429134 AFTER HOURS USD30.2 -0.47 -1.5324421258558851% Volume (Delayed 15m) : 13788 P/E Ratio 24.1496062992126 Market Cap 1992476442.63954 Dividend Yield 3.7495924356048254% Rev. per Employee 188638 More quote details and news » / DBD
|Chemtura / CHMT
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|Weatherford Internationa wft 8.373205741626794% Weatherford International Ltd. U.S.: NYSE USD9.06 0.7 8.373205741626794% /Date(1443819722022-0500)/ Volume (Delayed 15m) : 14127497 AFTER HOURS USD9.06 % Volume (Delayed 15m) : 123251 P/E Ratio N/A Market Cap 7038578514.47049 Dividend Yield N/A Rev. per Employee 228357 More quote details and news » l / WFT
|Post Holdings post 2.2576812086233238% Post Holdings Inc. U.S.: NYSE USD60.24 1.33 2.2576812086233238% /Date(1443819799038-0500)/ Volume (Delayed 15m) : 778173 AFTER HOURS USD60.24 % Volume (Delayed 15m) : 9029 P/E Ratio N/A Market Cap 3656688561.66412 Dividend Yield N/A Rev. per Employee 551132 More quote details and news » / POST
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Florida Attractions Association Membership
Sarasota, Florida – June 20, 2014 - Grapevine Communications, the area's leading full-service advertising, marketing and public relations agency, has joined the Florida Attractions Association. This newly forged partnership solidifies the ad agency as a business committed to the highest levels of courtesy, hospitality and integrity when promoting and advancing the interests of the attraction industry.
The Florida Attractions Association represents the Sunshine State's world-renowned tourist attraction industry, which employs over one million Floridians and is responsible for welcoming more than 84 million visitors each year. Membership in the Florida Attraction Association is very prestigious, as members are lauded for being "Florida's finest family attractions."
"Florida is home to some of the world's best, most widely visited family attractions and experiences,"
Grapevine Communications provides full-service advertising, marketing and public relations services to clients nationwide. The firm is the most award-winning advertising agency in Sarasota, Florida; voted 2014 Best Marketing/PR Agency by SRQ Magazine Readers, and earned the 2010 Frank G. Berlin, Sr. Small Business of the Year Award by the Greater Sarasota Chamber of Commerce. For more information on Grapevine Communications, contact Miranda Spinner at firstname.lastname@example.com or 941-351-0024.
Grapevine Communications
Grapevine Communications


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1989 Buick Century • 144,916 miles
My 89 century runs fine with no missing As I drive down the interstate the engine just dies lik I'm not getting spark or fuel as I coast down the road the engine start right Back up without me turning the key I have replaced the ignition switch, icm, fuel pump, coil packs, map sensor, fuel pressure regulator, plugs, wires, air and fuel filters, computer, grounded the engine, I also drove the car with a computer hooked to it and no code came up not even when the car died. Keep in mind that the radio and all still are working and do not shut off unless I turn it off when the engine stalls any idea what the problem could be please help
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Puppetry from the U.S., Japan, Belgium and Colombia will be featured in the 2015 LA MAMA PUPPET SERIES set for November 5 to 29 on all four of La MaMa's stages in New York City. This biennial festival highlights new contemporary puppet theatre from many of the world's leading puppet artists during the month of November, including Heather Henson, Ty Defoe, Tom Lee, Koryu Nishikawa V, Loco7 Dance Puppet Theatre Company and Maiko Kikuchi. (more...)
Sandglass Theater's New Visions Puppetry Series welcomes the return of Finn Campman's Of Bread and Paper. This evocative piece, which played to sold-out audiences at the 2012 Puppets in the Green Mountains festival, invites you to enter a world of light and shadow where layers of meaning are glimpsed and gradually revealed. Performances are Friday and Saturday, October 11th and 12th at 7:30pm. Tickets are $16 general and $13 for students and seniors. (more...)
La MaMa Experimental Theater Club, which for over 50 years has produced a uniquely global array of experimental theater, dance, performance art, and music, launched CultureHub in 2009 with its longtime partner the Seoul Institute of the Arts. La MaMa founder Ellen Stewart was a pioneering force in the movement behind the now-commonplace black box theater, an architectural shift that revolutionized the performing arts. CultureHub builds upon Stewart's legacy of innovation, implementing state-of-the-art telepresence technology to transform the black box for a new century and bring artists and audiences from various international locations together in performance, without having to be in the same physical space. (more...)
In 1962, when Ellen Stewart invited puppet artists from Korea, La MaMa began a long love affair with all things puppetry. The form has been an integral part of La MaMa's artistic vision for more than a half-century. The institution demonstrates the depth and breadth of its commitment with the La MaMa Puppet Series 2013, which, for three weeks (November 7 - 24), fills all three La MaMa theaters with a wide array of productions-both emerging and established artists, from countries around the world, offering something for theatergoers of all ages. (more...)
Two years into its second half-century, La MaMa, under the artistic direction of Mia Yoo, continues the omnivorous work of its founder, the late Ellen Stewart. The institution's fall 2013 season is a mixture of established artists and forms La MaMa has long supported (Lee Breuer, Dario D'Ambrosi, puppetry) and celebrated artists and programs new to La MaMa (Irina Brook, Chiori Miyagawa and Alice Reagan, Pascal Rambert, Maureen Fleming, Dan Fishback and Max Steele, and many others). Show-by-show descriptions are below. (more...)
Rehearsal For A Sicilian Tragedy will screen in the Stranger Than Fiction Series at IFC Center tonight, January 8, 2013. John Turturro and director Roman Paska will be in attendance. (more...)
Rehearsal For A Sicilian Tragedy will screen in the Stranger Than Fiction Series at IFC Center on January 8, 2013. John Turturro and director Roman Paska will be in attendance. (more...)
In Rehearsal for a Sicilian Tragedy, actor John Turturro (O Brother Where Art Thou?, Barton Fink, Do the Right Thing) takes audiences on a haunting, intimate journey to his maternal homeland of Sicily. There, while exploring the island's vanishing traditions, he is taken under the wing of one of the puppet theater's few remaining practitioners, Mimmo Cuticchio, who instructs him in the distinctively Sicilian art of puppetry. (more...)
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The Sundance Institute Theatre Program today announced the three projects selected for its 2012 Theatre Lab at White Oak in Yulee, Florida. (more...)
The National Puppetry Conference is proud to announce the 21st annual Puppetry Conference at the Eugene O'Neill Theater Center. Hands down, the best venue in which to collaborate, experiment, explore and develop your ideas and talents relating to puppet theatre, the National Puppetry Conference is open to puppeteers, theatre designers, actors, musicians, directors, artists, producers, playwrights and students. The Pre-Conference intensive workshops run from June 8th to the 10th with the full Conference beginning June 11th and culminating with public performances June 18th and 19th. (more...)
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Little Angel Theatre and Reel Islington announce London's first ever puppet film festival from 25-27 March 2011. As part of the ongoing 50th birthday celebrations of Little Angel, its intimate 100 seat theatre will be transformed into a cinema for this one weekend and the films shown will appeal to all ages. (more...)
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Local Emergency Planning Committee to Meet
The Local Emergency Planning Committee will be meeting on Wednesday, October 7, 2015, from 2 to 4 p.m. at the Gilbert Fire Administration Building, 85 East Civic Center Drive in Gilbert. The public is invited to attend. ....More Details
Exercise to Test Palo Verde Emergency Response Plans
The state of Arizona, Maricopa County and Palo Verde Nuclear Generating Station (PVNGS) will participate in a federally-evaluated joint exercise of the Palo Verde Onsite and Offsite Response plans on Wednesday, Sept. 16. ....More Details
Public Invited to Comment on County Mitigation Plan
Hazard Mitigation planning can significantly reduce future risk and potential losses in the event of a disaster. Public input is extremely important. ....More Details
One Month Left to Apply for SBA Disaster Loans
August 5, 2015, is Arizona private nonprofit organization's deadline to apply for SBA federal disaster loans for losses related to last year's storms ....More Details
UPDATED: Public Invited to Local Emergency Planning Meeting
LEPC to meet on Wednesday, July 8, 2015, at 2:00 p.m. in Peoria. . . ....More Details
The Heat is ON
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Secretary of Ag declares drought disaster in Maricopa County
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SBA Economic Injury Disaster Loans Available
Small, nonfarm businesses in 15 Arizona counties and neighboring counties in New Mexico and Utah are now eligible to apply for low-interest federal disaster loans from the U.S. Small Business Administration (SBA). ....More Details
County Emergency Managers seek public input
Preparedness not on this year's list of resolutions? Maybe it should be. The Maricopa County Department of Emergency Management is releasing its annual survey and encouraging residents to provide input into the planning process while gauging their o ....More Details
One Month Left for Private Non-Profits to Apply
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Nuclear Plant to Sound Emergency Sirens
Annual Test Part of Federal Requirements - On Wednesday, November 12, Palo Verde Nuclear Generating Station, will test the 48 outdoor warning sirens located within the 10-mile emergency planning zone of the nuclear generating station. ....More Details
SBA Disaster Recovery Centers Will Close Next Week
The center in Phoenix will close at 5 pm on Wednesday, October 29. The centers in Glendale and Mesa will close at 5 pm on Friday, October 31. ....More Details
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by Fleming, Ian
Publisher:Random House Books for Young Readers
She was definitely magic - a car with something so special that the Potts family ignored her rust and cracked leather upholstery and lovingly restored her to all her former glory. And once christened "Chitty Chitty Bang Bang for the noises she makes, the beautiful touring sedan shows her gratitude as only she can - first by rescuing the Potts from a tiresome traffic jam (she flies them out of it!) and then by whisking them off to a vacation on the coast of France. So it looks like plenty of fun in the sun until one of the kids uncovers a mysterious cave tucked away in the hillside and sends Chitty in to investigate. How could they have known that it's the secret hideout of Joe the Monster - the man who just happens to be Europe's most dastardly gangster? A fantastic concoction by the author of James Bond.
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Moda Health has joined forces with hospitals from throughout the state to transform the delivery of healthcare and expand its reach
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The statewide health purchasing boards – OEBB and PEBB – were primed to finally choose a permanent administrator when they convened early yesterday morning in executive session.
Oregon's Public Employee Benefits Board's consultants have devised a plan which may delay making state workers with families pay for an increase to their healthcare premiums, which could come from
After an unprecedented decrease in healthcare costs for state workers in 2013, the inflation rate for the Public Employees Benefit Board was right back up to 7.4 percent per employee in 2014 for those covered by the state's self-insured health plan administered by Providence.
A growing economy allowed Gov. John Kitzhaber to release a budget Monday that calls for big increases to state funding for both the Department of Human Services and the Oregon Health Authority, whose budgets will grow by double-digit percentages.
Providence Health Plan has refused to pay claims for hospital patients in Hermiston if it later deems the hospitalizations unnecessary, leaving Good Shepherd Medical Center to eat the cost for treating those patients, hospital officials have told The Lund Report.
Oregon's dominant healthcare players are expected to make major announcements in the coming weeks that could transform the landscape, The Lund Report has learned.
The state will be taking more time to find a full-time replacement for Joan Kapowich, the ousted head of the Public Employees Benefit Board and the Oregon Educators Benefit Board.
The Public Employees Benefit Board on Tuesday inked the set of health options for public employees and approved premium rates that will rise only 0.7 percent above 2014 premiums -- a second year in a row that premiums have risen less than 1 percent.


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More earthquakes vibrate Arkansas
Quake strong enough to be felt 200 miles away, scientist says
By: Associated Press - Texarkana Gazette
LITTLE ROCKAn earthquake powerful enough to be felt 200 miles away struck Greenbrier about 2 a.m. Friday, when most residents were asleep. Many probably never woke up.
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Protect Your Tech with EPS: Essential Protection SystemOctober 10, 2014 Comments Off
Logitech knows a thing or two about safeguarding against bumps, scratches and spills – and the dire need for it.
Logitech knows a thing or two about safeguarding against bumps, scratches and spills – and the dire need for it.
If you love someone, let them go. Especially if there's a more powerful and intuitive love waiting for you around
The advent of both the global workforce and cloud services has revolutionized business. With more geographically dispersed and remote workforces,
Unified communications (UC) may now be mainstream, but what are the implications? The liberation that UC gives businesses helps empower
Logitech for Business Headset Survey Sweepstakes ("PROMOTION") OFFICIAL RULES NO PURCHASE NECESSARY. OFFER VOID WHERE PROHIBITED OR RESTRICTED BY LAW.
North America aims to show off its strengths in the global eSports scene. As sponsors of two North American teams–Cloud9
Whether playing mods or building them yourself, check out the Logitech G600 MMO Gaming Mouse if you want to take
We're back from PAX! Logitech G was all over PAX Prime in Seattle this year. Our eSport teams battled it
Step by step, our video game project is picking up steam! We're now on stage three of our crowdsourcing experiment,
Think you're faster than the fastest mouse in the world? Prove it! Logitech G is excited to be at PAX


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United Stations Radio Networks, Inc. is the largest independently owned and operated full service radio network. The company currently distributes and producesMore
$25 mil. - $50 mil.in Revenue
100 - 250EmployeesContact people at this company
United Stations Radio Networks 1065 Avenue Of The Americas 3Rd FloorNew YorkNew York10018United Statesview map
(310) 268-9292(212) 869-1115Fax
Pro2015_Iteration9_NoTests.148[02] SEIDXWK-41


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Quick Search
1941 Ford Super Deluxe
1941 Ford 2 Door Super Deluxe Coupe, in all original condition Price reduced.... was $25000....New Project Started.Highest quality frame off restoration, no disappointment,
... $20,000
1946 Ford Super Deluxe
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1946 Ford Super Deluxe
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Illinois Public Media
All articles tagged Autism
Coins Under The Couch Cushions And False Hope
EIU Turns To Crowd-Sourcing To Help Fund Autism Center
Boys With Autism Or ADHD More Prone To Overuse Video Games
Blending Approaches to Meet Individual Needs of Young Children with Autism
Challenging Behaviors in Children with Disabilities: Treatment, Intervention, and Parental Stress
Early Red Flags of Autism Spectrum Disorders: From Early Identification to Early Intervention
Page 1 of 1 pages
WILL Highlights
Vintage Vinyl is coming!
The Vintage Vinyl Sale to benefit Illinois Radio Reader returns on October 3. Click for the latest info.
WILL News wins PRNDI Award for "Unmet Needs" Radio Doc
The 2014 radio documentary, produced by former WILL staff and hosted by Scott Cameron, won second place in the Long Form Documentary category among medium-sized stations.
WILL Ag Director Dave Dickey retires
He carried on the farm broadcasting tradition, while innovating on the Internet.


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Best Chicago Marketing Speakers
A while back, one of our favorite digital marketers, DJ Waldo, wrote a roundup of the best marketing speakers. It got me thinking, who are the best Chicago marketing speakers?
I posted this on Facebook and got back over 60 comments with a list of the best marketing speakers in the industry.
My other motivation behind this, is that we have Content Jam, a one-day content marketing event, fast approaching and this will help us when considering speakers for the event. From that one Facebook post, we were able to come up with a list of 27 Chicago marketing speakers. Sweet!
Is there anyone that we missed from this list? You can vote up or down anyone from the list, vote yourself in, or leave a comment to add someone.
Best Chicago Marketing Speakers
We believe in the power of great communications. We also believe most individuals and corporations get it wrong. Let us help you Change Your Orbit.
Founder, ONE80: Bringing Conversations & Storytelling Back To Business... Through Mentoring (Programs, Events & Marketing). Board of Directors Chicago #MPI. Chicago
CEO Arment Dietrich. Author @spinsucks, blog and book. Co-author Marketing in the Round. Speaker. Avid cyclist. A foodie. Loves shoes & wine. Chicago, IL
Web strategist and co-founder of Orbit Media (@orbiteers). Speaker, content marketer, environmentalist and author: http://www.orbitmedia.com/contentchemistry. Chicago, IL - Ravenswood
Fired. Blissful self-employment since. Helps people live a Life of Yes. Brazen Careerist Top 20 Young Professional. Nervous TEDx speaker: http://t.co/sZ5LQzFjCY. Chicago
Marketing Director - Sears @PartsDirect | Speaker & Consultant http://312digital.com @312digital | #SEO | #Content | #Digital | #CMO | Adjunct @ElmhurstCollege. Chicago, IL
President at @LightspanD. Credo: Make no little plans. Be bold, brave &kind. #SCUBA rescue diver. Waging war on bad #socialmedia & #digitalmarketing. #lovedata. Chicago, IL
Creative Technology Director @EducoWeb; Midwestern transplant; lover of TNG marathons, webcomics, and all things tech. Chicago, IL
Professional brainstormer, do-it evangelist, sassy speaker, lover of chocolate, founding mom of The Founding Moms. Chicago, IL
I think about the internet. A lot. You'd be surprised how well that's worked out so far.
Chicago area B2B Marketing Technologist | Marketo fan | Demand Generator. Experienced in thought leadership, branding, content marketing & marketing automation. Chicago, IL
Customer experience leader/student; fascinated by social media; working mom; friend to great thinkers. Chicago
Executive Dir @DownsizeForLife, Host @GayAgendaLive, Retired Entrepreneur, DePaul Faculty, Advisor @GeekBarChicago. Globe Trekker, Geek, Whiskey Drinker. Chicago, IL
CEO & Founder @Concentric_CM. Overly curious storyteller & fan of all things media. I love #running and miss bagels. #GF #contentmarketing
Liz Strauss
Founder of SOBCon, social business strategist. It's only fun when it's brilliant strategy, high return, AND connects customers in a meaningful way. Google: liz. Chicago
Brad Farris
Father of 5, Passionate about growing small businesses, dedicated Chicagoan. Principal @AnchorAdvisors. Editor @EnMastBusiness, Co-Host of @bdybiz. Chicago, IL
Hash tag abuser in 10-step program because I can't commit to 12. Professional line crosser. TEDx talker (http://ow.ly/ilU6Q). Student of smart and funny. Chicago, IL
Jill Pollack
Founder and Director of StoryStudio Chicago: the center for writing and writers. Graduate of the 10,000 Small Businesses program (10KSB). Chicago
Kickstart market demand, agile marketing, social media, Chicago Booth MBA, growth hacker, blogger, speaker, marketing automation geek, long distance runner. chicago
Susan Silver
The latest from Susan Silver (@ArgentumStrat). Timeshare VP of Marketing® for small to mid-sized businesses. Marketer, entrepreneur. Intrepid traveler, passionate water skier, baker of tasty cookies. Chicago, IL
Chief Strategist Compass(x) Strategy. There is always money in the banana stand.
Tim Frick
Owner of Chicago #BCorp @Mightybytes. Cyclist & @ClimateRide board member. Author of books on media and marketing. Speaker, educator. Beer brewer. Chicago, IL
Social media director at @CrainComm. Faculty at @UChicago. Co-created @ChicagoNow & reported for @Time. Love meeting passionate people. Chicago, IL
JD Gershbein
Are you using LinkedIn wisely? No? I can help. Please visit my LinkedIn profile at http://www.linkedin.com/in/jdgershbein. Chicago NW suburbs
Based in Chicago, Marianna travels worldwide to deliver keynote speeches, workshops, and professional coaching designed to help her clients develop and master their speaking skills.


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With 1.7 million freelancers, we'll match you with the perfect talent.
The client has made the following changes to the job.
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Job Description:
I am looking for a complete Corporate Identity kit for my company. I will send, via PMB, several website links to identify the type of work we provide as well as company name. I need you to interpret type of work and create logo. I am looking for a clean, professional look. We will be using logo for auto decals as well.
The following are required:
1. Corporate Logo (delivered in several formats/sizes - web, word, business card, envelope)
2. Microsoft Word Template
3. Microsoft PowerPoint Template
4. Business Card design layout (to be delivered in a 'print' ready format).
Solution should be professionally designed and unique.
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text: Personalised I Phone/I Pad Case For I Dad by Tailored Chocolates and Gifts £22.95$49.73€33.96$37.75 5 customer reviews(5) In stock £18.50$40.08€27.37$30.43 delivery to United States Receive this item 5-10 working days from dispatch International delivery available which devicewhich device (required)iPhone 4/4s WhiteiPhone 4/4s BlackiPhone 5 WhiteiPhone 5c WhiteiPhone 5 BlackiPhone 5C BlackiPad 2,3,4 Black (+ £7)iPad 2,3,4 white (+ £7)iPad mini white (+ £4)iPad mini BlackiPad Air (White) (+ £7)iPad Air (Black) (+ £7)iPad Tri Flod shell PINK (+ £17.04)which device (required)iPhone 4/4s WhiteiPhone 4/4s BlackiPhone 5 WhiteiPhone 5c WhiteiPhone 5 BlackiPhone 5C BlackiPad 2,3,4 Black (+ $15.16)iPad 2,3,4 white (+ $15.16)iPad mini white (+ $8.66)iPad mini BlackiPad Air (White) (+ $15.16)iPad Air (Black) (+ $15.16)iPad Tri Flod shell PINK (+ $36.92)which device (required)iPhone 4/4s WhiteiPhone 4/4s BlackiPhone 5 WhiteiPhone 5c WhiteiPhone 5 BlackiPhone 5C BlackiPad 2,3,4 Black (+ €10.35)iPad 2,3,4 white (+ €10.35)iPad mini white (+ €5.91)iPad mini BlackiPad Air (White) (+ €10.35)iPad Air (Black) (+ €10.35)iPad Tri Flod shell PINK (+ €25.21)which device (required)iPhone 4/4s WhiteiPhone 4/4s BlackiPhone 5 WhiteiPhone 5c WhiteiPhone 5 BlackiPhone 5C BlackiPad 2,3,4 Black (+ $11.51)iPad 2,3,4 white (+ $11.51)iPad mini white (+ $6.58)iPad mini BlackiPad Air (White) (+ $11.51)iPad Air (Black) (+ $11.51)iPad Tri Flod shell PINK (+ $28.03) dad's name (optional) descriptive word 1 (required) descriptive word 2 (required) descriptive word 3 (required) add personalised mug with same detailsadd personalised mug with same details (required)Add Mug (+ £10)No Thanksadd personalised mug with same details (required)Add Mug (+ $21.67)No Thanksadd personalised mug with same details (required)Add Mug (+ €14.79)No Thanksadd personalised mug with same details (required)Add Mug (+ $16.45)No Thanks quantity by Tailored Chocolates and Gifts Location: Cheshire, GB read seller's profile see seller's complete range more items from this seller Best Dad In The World Chocolate Bar £5.95$12.89€8.80$9.78 Personalised Destination iPhone Case £22.95$49.73€33.96$37.75 Personalised iPhone Case Loves £22.95$49.73€33.96$37.75 Chalk 'Love Heart' Mug £12$26€17.75$19.74 Father's Day Personalised Chocolate Bar £5.95$12.89€8.80$9.78 Personalised 'Likes' For IPad Mini £26.99$58.48€39.94$44.40 view all you may also like PRODUCT DETAILS CUSTOMER REVIEWS DELIVERY RETURNS can be personalised ask seller a question save for later Make your Dad's iPhone/iPad stand out from the croud with this fun & funky personalised case for iPhone4 and 4S, 5 and Ipad. iPhone, iPad now iDAD..... The pefect gifts for Father's Day, everyone should have an iDad!!! Choose from three different descriptive words that describe your Dad... i.e Loving. Sporty. Fun. or Daft. Smiley. Legend. Whatever words you use to describe your Dad, it will be personal to him and you, showing him how much you care. If you'd prefer something to protect the front and the back of your iPad, choose our shell case. Slim tri-fold case for your iPad offers a sturdy folder design providing protection to the screen and the back of the device. Magnetic strip built inside for secure closure with smart cover sleep/awake function The iPhone4/4s cases are available in white. The iPhone 5 cases are available in black & white NOW AVAILABLE FOR IPAD and IPAD MINI Please note that the white plastic cases have a black ring around the camera lens hole to prevent glare when taking pictures. made from: Plastic dimensions: Suitable for iPhone 4/4s and NOW 5 product code: 216263 5 customer reviews Wed 23 Apr 2014 No comment Mon 21 Oct 2013 No comment supplied. Tue 25 Jun 2013 Excellent service and product. Tue 25 Jun 2013 No comment supplied. Wed 06 Mar 2013 So many people have commented on the cover it is really unique and fun. see all customer reviews hide some customer reviews read about our product rating system ratings guide trusted independent customer feedbackforum excellent bad good poor This product is dispatched to you by Tailored Chocolates and Gifts. MAINLAND UK order now and receive this item on or before price Standard Delivery Saturday 10 October £2.75$5.95€4.06$4.52 Express Next Day 1pm Wednesday 7 October £9.70$21.01€14.35$15.95 Saturday Delivery Saturday 10 October £15.70$34.02€23.23$25.82 NON-MAINLAND UK estimated delivery price Highlands & Islands of Scotland 2-5 working daysfrom dispatch £2.75$5.95€4.06$4.52 Northern Ireland 2-5 working daysfrom dispatch £2.75$5.95€4.06$4.52 Other UK Islands 2-5 working daysfrom dispatch £4.95$10.72€7.32$8.14 INTERNATIONAL DELIVERY estimated delivery price Western Europe 2-5 working daysfrom dispatch £11.50$24.92€17.01$18.91 Rest of Europe 5-10 working daysfrom dispatch £11.50$24.92€17.01$18.91 USA & Canada 5-10 working daysfrom dispatch £18.50$40.08€27.37$30.43 Asia & Australasia 5-10 working daysfrom dispatch £19.50$42.25€28.85$32.08 Rest of the world 5-14 working daysfrom dispatch £19.50$42.25€28.85$32.08 You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Tailored Chocolates and Gifts's return policy


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Breck Inn
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Shuttle bus service
- Continental Breakfast
- Non-smoking rooms
- Wireless internet connection in room (free)
- Free High-Speed Internet
- Wireless internet connection in public areas
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TripAdvisor Reviews Breck Inn Breckenridge
Travel Blogs from Breckenridge
Day 6
... into Grand
Canyon time, we settled for viewing the cliff dwellings from a distance. We
were also treated to a nice show from upwards of 20 vultures swooping in and
around the canyon.
It was finally our first night camping, and we had a spot
inside the park. We ambitiously planned to make chicken kabobs and a baked
potato and sweet potato. ...
Back in Breck!
Today we find ourselves in Breckenridge Colorado. We love this place so much. The first step out of the RV gets me every time. There is just something about the smells of an Alpine Forrest that immediately quiets the mind and soothes the soul. It simply stops me in my tracks. There is not better summertime weather anywhere than at high altitude in Colorado. Days are always in the mid 70's and the nights drops down for great sleeping temps. In addition ...
Today we woke up at about 7:15 and Uncle Doug had already bought breakfast for us. Then Dad and Uncle Doug took our car to the car shop to get the brakes fixed. Then we all got dressed and ready. Auntie Al and the kids and Uncle Doug went to the car to get the coats (and Ben's camera) for the Gondala. Then we took the shuttle to the Gondala, to the half way point on the Mountain. When we got up to the top of the Gondala, AA, UD, Dad and Ben and Edie (mom and Tommy ...
Rocky Mountains await
... Alamo rental car and head west right into the storm front. By the time i reach the top of the Rockies the weather is appalling. Next to zero visibility, plenty of snow falling. Finally make it to Breckenridge, which looks very pretty as the whole area is covered in snow.
A day to do very little, just adjusting to the high altitude and low oxygen levels.
Drove the scenic route to Leadville and returned back via Minturn. Some very pretty scenery and some ...
Maroon Bells by morning
... of mine…bikers. Not all bikers. I mean I respect their right to exercise and enjoy nature. Everywhere I have ever traveled there have been bikers. But for some reason there is an extraordinary amount of just complete ******** here. There are way more bikers than I have seen anywhere else so maybe its just the sheer quantity increases the chances of there being a few more inconsiderate rude jackasses but it is really a noticeable ...


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Set in Rayong Province, "Together" tells three stories of love linked by rain. In the first story, a married woman (played by Thai Princee Ubol Ratana) is visited by the father who abandoned her as a child, currently alone and suffering from Alzheimer's disease. In the second, a young professional couple is having marital difficulties when the husband suddenly begins going blind. In the third, a pair of high-school sweethearts find out the girl is pregnant way before the couple are ready to be parents.
Keywords: alzheimer's-disease, blindness, rain, teenage-pregnancy, thailand
Adil, a young Muay Thai kick-boxer, has just fled an honor fight-to-the-death. Ilham, an assassin who is also Adil's stepbrother, is promptly hired by the organizer of the death match to kill the fugitive. Looking for somewhere to hide and recover, Adil and a childhood friend take shelter in the Bunohan boxing club where Adil started his career. Ilham, meanwhile, has never been back to Bunohan since the day he left many years ago. Upon returning, memories of loneliness and abandonment flood his mind, and he experiences waves of resentment and regret. Bakar, the third brother, has also come home from the city; ostensibly a respectful schoolteacher, he is in reality a greedy and ruthless person, and is trying to convince his father to sell a burial ground to a construction company.
A car crash on a bridge causes Keng and Prae a big trouble in their lives. When they regain consciousness, they realize that their souls have switched bodies. Things get even worse when both realize the unique problems of having a body of the opposite sex. Trapped inside each other bodies, Keng and Prae must find the way to return to their own bodies, but it's not so easy when many problems keep popping up.
Keywords: body-switching, thailand
Reggie, the aspiring singer; Chart, the troubled rich boy; and Peter Parker the ex-seminarian; share an apartment in the East Village (New York City) in this story dealing with AIDS, sexuality and living in NYC of the late 80's.
Keywords: aids, gay-interest, new-york-city


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[quote:Spiritoftruth111 26530436:MV8yMDQ5MzE5XzM0NTI5NjA3XzVFRThGRDRF] Let it be known in day of judgement God and Christ spoke unto mankind on forum of glp but the wicked offended the good spirit so they withdrew and let they whom have not heeded the warning know that ye shall be told in day of jugement we know ye not and be numbered as the goats. Let your afflictions to come humble you and if you are truly sincere we shall forgive, but as it stand now Heaven shall not abide in those whom have spoke as a serpent. For ye whom were humble I send you my blessings and tell ye to begin to prepare for the end, for world war is not long away and the beginning of tribulation soon after. We dust our feet and leave, when the good spirit saith return we shall for now we will leave for a time. Ehyeh Esher Ehyeh peace. [/quote]
Original Message
Let ye know now the true Good Shepard that ye seek.
Let a mystery be given unto ye to know the times in which I shall do these things.
1 And I saw when the Lamb opened one of the seals, and I heard, as it were the noise of thunder, one of the four cbeasts saying, Come and see.
2 And I saw, and behold a white horse: and he that sat on him had a bow; and a crown was given unto him: and he went forth conquering, and to conquer.
3 And when he had opened the asecond seal, I heard the second beast say, Come and see.
4 And there went out another horse that was red: and power was given to him that sat thereon to take apeace from the earth, and that they should kill one another: and there was given unto him a great sword.
5 And when he had opened the third seal, I heard the third beast say, Come and see. And I beheld, and lo a black horse; and he that sat on him had a pair of balances in his hand.
6 And I heard a voice in the midst of the four beasts say, A measure of wheat for a penny, and three measures of barley for a penny; and see thou hurt not the oil and the wine.
7 And when he had opened the fourth seal, I heard the voice of the fourth beast say, Come and see.
8 And I looked, and behold a pale horse: and his name that sat on him was Death, and Hell followed with him. And power was given unto them over the fourth part of the earth, to kill with asword, and with hunger, and with death, and with the beasts of the earth.
Let it be known the first four seals to be broken also represent the four horsemen of the apocalyse, let it be known the whitehorse represents the deciever whom shall bring forth the world war to come he that is the Antichrist the king over the antichrists.
Let it be known that the world war will bring pestilence, famine and death. That those whom die in it shall be taken to Hell for they died in their sins. Death comes and Hades follows soon after.
Let ye know also the ecomony shall collapse for a time and a new system come out of the ruins having power of the first system of beast, in which money shall no longer be the way but a new system shall come of simlar design.
Behold I am He whom spoke these things to John the revelator and showed him the things to come and now I translate it for you so ye may know when I begin to break the Seal. Know this all those whom have pretended to be Me shall have great woes in times to come as the Seals are broken and if they repent not Hell shall have them. Many have spoken in my name without my authority and corrupted the field with their poisons.
I am the Truth the Light and the Life no man women nor child goeth unto the Father but by me, I am the bridge to the eternitys there is no future beyond Hell outside coming through me. Man is bound and destined for condemnation and eternal suffering I have offered the world and those whom would believe and follow the example and be humble in doing so a alternative outcome.
Hell is all around you your universe is the realm of darkness the Light holds it back for a time, the spirit is protected while in the body but the body is also corrupt and binding to the spirit. Many whom have died did not go to good places very few even make it to the place of waiting and none but a few have seen Heaven.
Ehyeh Esher Ehyeh
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Reviewed By Ramon G (MCALLEN, TX) Reviewed for a 2005 Ford F-150 —7/29/2015 10:52 PM
Easy to install and looks great...very satisfied and recommend this product highly.
Reviewed By Daniel V (WARMINSTER, PA) Reviewed for a 2005 Ford F-150 —6/30/2015 5:47 AM
Overall I'm pretty happy with the cover. In order to get a seal most of the way around the bed the clamps need to be turned down pretty tight which causes some bowing in the support rails. Even tightened like that it's still not a perfect seal, but even after some pretty heavy rains there has been no water in the bed. I would most likely buy this cover again or try the similar priced and functioning American Tonneau.


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|Reviews for With Love
| Guest chapter 1 . 7/11/2014
" so just shut up and kiss me "
I think iv heard something like that before in a song or whatever
| Guest chapter 1 . 6/6/2014
Woah I'm surprised u didn't have smut after what hikaru said XX
| Fem2PItaly chapter 1 . 6/26/2013
Kyaaaa! You made me think that Kao-chan died! DX But then he wasn't, so I was happy. ;) A cute story!
| 1fallenangel7 chapter 1 . 3/1/2013
| li ross chapter 1 . 2/24/2010
Ok, I considered killing you, just as much as Hikaru must have considered killing whoever told him Kaoru was dead, but I ended up enjoying so what can I say?
Now I'm laughing at the fact I almost believed he was dying.
Keep on writing please
Au revoir
| PrettyAmethystPrincess chapter 1 . 11/28/2008
Oh my god! This story almost had me in tears! *sniff sniff* And then when I read the ending part, I felt so stupid! .
But anyways, I loved the story!
| ChocoCoatedLemons chapter 1 . 9/21/2008
i was like all sad about this until the end, then i started laughing. I can't get mad at you though, because this was really good
| Kuma-cchi chapter 1 . 3/21/2008
Hahah! Hi-five! Yeah I am so sick of those depressing angsty fics about Kaoru pining after Hikaru who completely disses him for Haruhi blah blah.. You rock! You just made my day LOL
| yours.to.hold chapter 1 . 12/1/2007
I'm not sure how many times you've heard this but I'm not angry that you turned a supposedly sad fic into a humor fic. I loved it. I am however mad that you said people who commit suicide are stupid. I think that's insensitive. Thet're just incredibly lost and no one is there for them and believes in them. If you had no one, no one understood how you felt, everyone told you you were fine or if you were fine but they kept saying you weren't. If they turned everything you did into something that showed you were depressed and tried to put you on meds you didn't need, If they told you over and over you were messed and needed help, if no one could except you for who you were. If you've never felt any of those things then no one can expect you to understand. If you believed that no one would miss you when you were gone and no one told you otherwise wouldn't you lose your reason to exist?At some point you'd give up, you'd lose hope. People who commit suicied are not stupid I know people who have. If no one believed in you you'd probablly give up to. Don't ever say people who are lost and feel like they have to reason to go on that are sick of crying themselves to sleep are stupid. They're not.
| Hopeless27 chapter 1 . 9/2/2007
aww, that's soo cute! I love the little twist in the end. Kaoru will probably frame the letter or something just to rub it in Hikaru's face. XD
| BokuraNoLoveStyle chapter 1 . 7/14/2007
argh ur evil lol i was gettin sad in the beginning see what u did i have tears now! lol but it turned good and it made me giggle heehee
| prettybabycatty1109 chapter 1 . 7/12/2007
the letters fooled me
i nearly cried
the end is pretty cute
got my heart XD
| i-see-faeries chapter 1 . 1/29/2007
Haha, very amusing. The letter had me going. Loves.
| alice chapter 1 . 1/15/2007
"Damn, Kaoru, they're coming again. My eyes hurt. The tears. They just won't stop. My eyes are already so sore but they won't stop. I'm begging you, please make them stop."
Oh wait. Were you trying to be serious?
| obsidian-rain chapter 1 . 12/12/2006
AW, That's so cute!


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Market growth expected for electronic health records, health information exchanges and telehealth
Spending on state and local health information technology systems is expected to rise by 19 percent during the next five years due to federal economic stimulus law incentives and other trends, according to a new report from the Input market research firm.
The total addressable market for health IT is projected at $9.9 billion in 2015, up from $8.3 billion this year, according to the report issued today.
Electronic health record (EHR) system spending is expected to be $2 billion of the total in 2015, up from $1.1 billion currently, wrote author Kristina Mulholland, senior analyst for the company's health care and information systems practice.
Related stories
Stimulus stokes $23B in health IT opportunities
EHRs: HHS walks a tightrope
State and local health IT also is expected to benefit from economic stimulus law funding for community-based health care center modernizations and e-record systems, Medicaid management information systems, health information exchanges and record-locator services and for public health systems and telehealth, the report said.
For example, $2.5 billion in stimulus law funding for community-based health care centers will drive spending for facilities modernization, e-medical records and workforce, the report said.
States will spend for Medicaid management systems as a result of increased enrollment due to continued unemployment and to reduce fraud and improve quality in Medicaid, the report added.
About the Author
Alice Lipowicz is a staff writer covering government 2.0, homeland security and other IT policies for Federal Computer Week.
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The outgoing speaker helped push forward data and transparency measures that have opened up the House of Representatives to the American people.
The Census Bureau announced plans to fold in new technology and third party data into its 2020 population count, but questions remain about the viability of the Bureau's enterprise IT.
A technology roadmap can help agencies reap the benefits FITARA has to offer. Here are the four stages of a successful effort.
In the newest Federal Employee Viewpoint Survey, feds show they're feeling better than they have over the past few years – but there's still room for improvement, especially in mission-critical IT.
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Use Smart Objects and a defined pattern to create this cool screened effect in Photoshop.
The Digimarc for Images 4 plug-in for Adobe Photoshop or Photoshop Elements (Windows only) embeds your own unique copyright information invisibly, then their Web crawling service constantly looks for watermarked images on websites, and reports the results back to the owner
There are always features that dont make it into the marketing materials. So, here are 14 InDesign features you may not know about.
Heres a simple and straightforward method for adding useful Table of Contents (ToC) navigation to your PDF documents.
Like many people, I was hesitant to try the video and 3D capabilities of Photoshop CS4 Extended … Then I realized that if you treat video as you would a photo, and think of 3D as another design element, its easier than youd imagine
This column is about creating templates with the .dwt extensiona timesaver when creating custom sites in Dreamweaver.
Beauty Box, a plug-in for After Effects, has a built-in, face-recognition engine. Just park on a frame in which the actor is facing the camera, click the Analyze Frame button, and you're done.
InDesign behaving strangely? Many times it is because users accidentally make changes to the default settings without knowing it. Jeff Witchel goes through some of the common default settings that can get messed up during the course of a normal work flow.


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Protect your horse from irritating insects and harmful UV rays with the Amigo® Fly Mask with Ears from Horseware® Ireland. PVC-coated polyester holds its shape.
Protect sensitive legs from pests with Fly Wrap® leg wraps. Made with soft shearling lining and imbedded stays. Can be worn constantly for 24 hour protection. Set of 4.
Protects your horse's sensitive ears from pests while riding, the Pessoa® Bling Crochet Ear Net features metallic striping and Swarovski crystals for added bling.
Roma® Mesh Leg Wraps protect against flies but allow airflow. Set/4.
The Rider's International Hug Fly Sheet prevents shoulder rubs and constriction while it protects against coat-fading UV rays, insects and dust. This unique mesh fly sheet features overlapping chest panels that move freely as your horse moves. It's easy to fit on developed horses-no more slipping or pulling.
The Amigo® Three-In-One Sheet from Horseware® Ireland eliminates worry that your horse isn't properly covered in fluctuating weather conditions. This unique sheet has a contoured waterproof, breathable top section to protect against heavy rain and mesh section airflow to prevent overheating. Overall, this sheet protects against flies and UV damage.
The Amigo® Barrier Sheet from Horseware® Ireland acts like lightweight body armor for your horse. This versatile sheet protects against UV rays, dirt and flies. Water-resistant, it has antibacterial properties and a lining at the shoulders, mane and tail.
The only flared wraps with a plastic stay under the fleece to keep them in place. Protects against insects, mud and sand and can be used over wraps when shipping.


text:
Self-made leaders from humble homes would make a welcome change, says Mzwandile Jacks.
South Africans seem to spend more time and money preparing for death than for life.
Telling off the West won't bring in much-needed foreign investment, says Leopold Scholtz.
The investment pipeline into South Africa remains robust and the country attracted R43bn in FDI in the previous financial year, according to a dti official.
The investigation into allegations of irregularities and misconduct within the SA Revenue Service (Sars) by audit firm KPMG has made a number of damning findings against its former acting head Ivan Pillay, his predecessor Oupa Magashula, and former executive Johann van Loggerenberg.
State-owned arms manufacturer Denel, until recently the poster child for well-run state companies, can't pay its suppliers after apparently exhausting its cash reserves on an
ill-advised acquisition.
The dicey, condition-laden plan to sell Evraz Highveld Steel and Vanadium out of business rescue faces a new threat: an aggrieved rejected bidder is going to court to try to put a different offer to creditors without the blessing of the business-rescue practitioners.
New record prices have been reached for both red and white wines at the 31st Nedbank Cape Winemakers Guild Auction.
The country's major gold mines and the Association of Mineworkers and Construction Union (Amcu) face the exact same deadlock they did in the previous round of wage talks in 2013.
Fancy a one-night private performance with new Daily Show host Trevor Noah? You can have it, but only if you have at least R3 million to spare for an hour-long performance, excluding flights and accommodation for his entourage.
A KPMG report has revealed that Sars has spent over R106m on a covert unit and recommends that former finance minister Pravin Gordhan and Sars commissioner Tom Moyane provide answers.
Britain will vote to leave the European Union in a planned referendum if it does not secure "robust, substantial and irreversible" reforms, warns the foreign secretary.
The Top Employers Institute announced that Old Mutual has secured the number one slot in the financial services and insurance categories for the fifth consecutive year.
Bursaries can help you study further to improve your qualifications and seek better work opportunities
There are 82 days left before Christmas and if you want to survive it without your wallet taking a pounding, now is the time to start planning.
South Africans are far more aware of price, not green issues, when choosing a new car, according to sale statistics.
SA could very well be on the cusp of a recession, and the majority of consumers are only one or two steps away from disaster or debilitating debt. Scary statistics from both an economist and a local financial wellness study point to the fact that it's high time to start keeping a sharper eye on your finances if you haven't done so already, writes Neesa Moodley
A Pacific free trade deal is within reach and New Zeeland warns that failing to finalise the pact would have worrisome long-term strategic implications.
China is seeking to assert its growing influence on global oil markets with a yuan-denominated crude futures contract.
The boardroom can be a viper pit filled with snakes camouflaged in suits...
It will be a welcome change if SA could be led by self-made men from humble...
Funeral costs have driven many families into desperate debt and trade...
A user wants to know if she can claim management fees as a tax deduction
Cees Bruggemans is clarifying that global 'what ifs' aren't forecasts, but questions.
The emissions debacle could put more pressure on marginal platinum-rich producers.
The Kgalagadi Lodge co-founder shares his entrepreneurial journey.
Why so many South Africans have carved out hugely successful careers in the UK.
Sadtu vows to fight the National Annual Assessments plan the same way it did apartheid.
You can buy your dream home if it's within your means and you can afford bond repayments.
Passion is what sustains you when you hit business hurdles, says Mogau Seshoene.
A KPMG report has revealed that Sars has spent over R106m on a covert unit and recommends that former finance minister Pravin Gordhan and Sars commissioner Tom Moyane provide answers.
The emissions scandal around German car maker Volkswagen has not been so great that Germany is no longer deemed a good place to do business, says Angela Merkel.
Do I have to pay tax in South Africa on my overseas income even though there is a double tax agreement between my country of residence and SA, asks a Fin24 user.
A coincidental meeting between two young entrepreneurs from Durban has turned into a successful construction business which now employs 52 people.
European shares have fallen after weak US jobs data, and Volkswagen stock lost more ground as a French investigation added to pressure.
The total brine injection allowed for whole poultry carcasses will be limited to a maximum of 10% compared to the maximum of 8% that was previously prescribed.
Amid all the controversy about the selection of the Springbok team, your money needs them to win.
It was 1986 – 29 years ago – and I still remember the excitement of watching M-Net 'open time', when the whole country could experience the 'magic' for just two hours a day.
MTN aims to make five South Africans millionaires in a summer promotion.
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Figure 7.
Functional groups significantly enriched among genes upregulated in Spalax muscle under acute and chronic hypoxia (mu3, mu6, mu10). Series names: muscle upregulation at 3% 6 hrs, 6% 6 hrs, 10% 44 hrs hypoxia, are denoted mu3 (blue), mu6 (red), mu10 (green), respectively. Line chart (triangles, diamonds, and circles) represents Benjamini adjusted P-value of term enrichment. Bars denote gene counts.
Malik et al. BMC Genomics 2012 13:615 doi:10.1186/1471-2164-13-615


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1/3 Carat Total Weight Genuine Blue & White Diamond Earrings in Sterling Silver
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MOSCOW — Seeming to be searching for the right word during a prerecorded television interview, Russian President Vladimir Putin suggested Sunday that one of the issues to be resolved in the Ukrainian conflict is "statehood" for the eastern regions now controlled by separatists.
That's a new idea, and if he meant it, it would raise the stakes considerably in the nearly 10-month-old Ukrainian crisis.
Earlier in the day, the European Union delayed imposing new economic sanctions on Russia but promised that if there is no policy change from Moscow within a week, more sanctions will be put in place.
The decision by the EU came as Ukraine's military said coast guard vessels were attacked from a beachfront in the village of Bezimenne, in the first significant land-to-sea battle of the conflict. Witnesses said men in military fatigues descended on the beach in armored personnel carriers and shot at two coast guard vessels, hitting one. Bezimenne is close to Novoazovsk, a town that pro-Russian insurgents took over late last week, allegedly backed by Russian soldiers and artillery.
As Putin's interview was being broadcast, Dmitry Peskov, the presidential spokesman, went into damage-control mode, saying that Putin was calling for dialogue, not sovereignty for the region, when he urged "substantive, meaningful negotiations" on questions concerning the "political organization of society and statehood in southeast Ukraine."
Putin has said repeatedly that he does not favor the breakup of Ukraine — though Russia seized Crimea from Ukraine in March — but wants greater autonomy for the east.
The term "statehood" suggests more than that, though, and if the word choice reflected a shift in Kremlin policy, it would ratchet up Moscow's challenge not only to Kiev, but also to the United States and European nations trying to force Putin to back down.
Alternatively, it could suggest uncertainty on Putin's part as to how he wants to push ahead on Ukraine.
"The president was talking about inclusive talks," Peskov said of the interview, in which Putin also called for an end to hostilities before winter and criticized European leaders for supporting Kiev's military campaigns against pro-Russian separatists.
Months ago, separatists backed by Russia declared independent republics in Luhansk and Donetsk, but Moscow has until now refrained from recognizing them.
Yet Western leaders believe that Russia has designs on eastern Ukraine.
In Washington, Sen. Robert Menendez, D-N.J., chairman of the Senate Foreign Relations Committee, said the United States should supply arms to Ukraine.
"We should be providing the Ukrainians with the type of defensive weapons that will impose a cost upon Putin for further aggression," he said on CNN's "State of the Union." "Thousands of Russian troops are directly engaged in what is clearly an invasion."
Though a few European leaders, such as Lithuanian President Dalia Grybauskaite, support aiding Ukraine militarily, the EU is highly unlikely to agree to such a course.


text:
Charity Finance Summit: the economic outlook is upbeat for charity investors
12 Oct 2015
Growth is the norm, not the exception, and charity investors bet against it at their peril, delegates...
Sorry for interrupting, but there is something we need to tell you...
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If you wish to restrict or block web browser cookies which are set on your device then you can do this through your browser settings, the Help function within your browser will tell you how.
Chris Cranie explains the strategic approach behind the two-year IT
improvement programme recently implemented at Terrence Higgins Trust.
Con Alexander explains the action one charity took after a memory stick containing donors' personal data was lost.
Paul Hughes describes how the Stroke Association improved its KPI dashboard for managers and trustees.
Audience response technology helped Peace Corps volunteer David Fields to improve the collection of data from the Ghanaian communities he helps, and therefore to better target his assistance.
Seven years after his charity's website was hacked by fraudsters, Neville Kyrke-Smith summarises the lessons learned.
RNIB's new CRM programme is designed to deliver the charity's customer strategy and a measurable return on investment, says Jane Deal.
ShelterBox is a disaster relief charity based in Cornwall which decided to look for a new accounting system having come to the conclusion that it had outgrown its existing Sage product. Accountant Rob Evans gives his thoughts on the new system he helped to put in place.
Gareth Jones hears about the Salvation Army's latest e-learning initiative.
New research shows that charities are key to driving digital participation. Jude Palmer at Digital Outreach explains how 'embedded outreach' is getting people online and how charities themselves are benefitting.
Charity IT Survey 2012
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CivilSociety.co.uk (without magazine)
from £151.20
12 Oct 2015
Growth is the norm, not the exception, and charity investors bet against it at their peril, delegates...
5 Oct 2015
James Brooke Turner invites readers to think creatively about the links between income-generating assets,...
2 Oct 2015
Kirsty Weakley examines Kids Company's annual accounts to identify clues about what led to its downfall.
13 Oct 2015
Despite having a global income of £82m, Sense UK and Sense International is continuing to set aspirational...
12 Oct 2015
Breast Cancer Care's 18-year partnership with BHS raised more in the last 12 months than in the previous...
8 Oct 2015
Sightsavers has an ambitious growth target, and that means ambitious fundraising campaigns. Its Million...
14 Sep 2015
Valerie Owen, OBE, chair of Swan Housing Association's board, describes how seeing a governance problem...
1 Sep 2015
A chief executive and employment lawyer offer advice on what to do when allegations of bullying heighten...
1 Sep 2015
Rushing towards a merger without following the proper procedures leads one charity into a bigger commitment...
19 Nov 2015
11 Feb 2016
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