text:
Are you Susumu Saito?Claim your profile
Publications (39)254 Total impact
Article: A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese[Show abstract] [Hide abstract]
ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons. Several susceptibility genes for ALS have been reported; however, ALS etiology and pathogenesis remain largely unknown. To identify further ALS-susceptibility genes, we conducted a large-scale case-control association study using gene-based tag single-nucleotide polymorphisms (SNPs). A functional SNP (rs2275294) was found to be significantly associated with ALS through a stepwise screening approach (combined P= 9.3 × 10(-10), odds ratio = 1.32). The SNP was located in an enhancer region of ZNF512B, a transcription factor of unknown biological function, and the susceptibility allele showed decreased activity and decreased binding to nuclear proteins. ZNF512B over-expression increased transforming growth factor-β (TGF-β) signaling, while knockdown had the opposite effect. ZNF512B expression was increased in the anterior horn motor neurons of the spinal cord of ALS patients when compared with controls. Our results strongly suggest that ZNF512B is an important positive regulator of TGF-β signaling and that decreased ZNF512B expression increases susceptibility to ALS.Human Molecular Genetics 06/2011; 20(18):3684-92. DOI:10.1093/hmg/ddr268 · 6.39 Impact Factor
Article: Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association Studies[Show abstract] [Hide abstract]
ABSTRACT: Because population stratification can cause spurious associations in case-control studies, understanding the population structure is important. Here, we examined Japanese population structure by "Eigenanalysis," using the genotypes for 140,387 SNPs in 7003 Japanese individuals, along with 60 European, 60 African, and 90 East-Asian individuals, in the HapMap project. Most Japanese individuals fell into two main clusters, Hondo and Ryukyu; the Hondo cluster includes most of the individuals from the main islands in Japan, and the Ryukyu cluster includes most of the individuals from Okinawa. The SNPs with the greatest frequency differences between the Hondo and Ryukyu clusters were found in the HLA region in chromosome 6. The nonsynonymous SNPs with the greatest frequency differences between the Hondo and Ryukyu clusters were the Val/Ala polymorphism (rs3827760) in the EDAR gene, associated with hair thickness, and the Gly/Ala polymorphism (rs17822931) in the ABCC11 gene, associated with ear-wax type. Genetic differentiation was observed, even among different regions in Honshu Island, the largest island of Japan. Simulation studies showed that the inclusion of different proportions of individuals from different regions of Japan in case and control groups can lead to an inflated rate of false-positive results when the sample sizes are large.The American Journal of Human Genetics 10/2008; 83(4):445-56. DOI:10.1016/j.ajhg.2008.08.019 · 10.93 Impact Factor
Article: Oishi, T., Iida, A., Otsubo, S., Kamatani, Y., Usami, M., Takei, T. et al. A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to Systemic Lupus Erythematosus in Japanese population. J Hum. Genet. 53, 151-162[Show abstract] [Hide abstract]
ABSTRACT: Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases with complex genetic components. To identify a gene(s) susceptible to SLE, we performed a case-control association study using genome-wide gene-based single nucleotide polymorphisms (SNPs) in Japanese population. Here we report that an SNP (rs3748079) located in a promoter region of the inositol 1,4,5-triphosphate receptor type 3 (ITPR3) gene on chromosome 6p21 was significantly associated with SLE in two independent Japanese case-control samples [P=0.0000000178 with odds ratio of 1.88, 95% confidence interval (CI) of 1.51-2.35]. This particular SNP also revealed associations with rheumatoid arthritis (RA) (P=0.0084 with odds ratio of 1.23, 95% CI of 1.05-1.43) and with Graves' disease (GD) (P=0.00036 with odds ratio of 1.57, 95% CI of 1.22-2.02). We found the binding of NKX2.5 specific to the non-susceptible T allele in the region including this SNP. Furthermore, an SNP in NKX2.5 also revealed an association with SLE (P=0.0037 with odds ratio of 1.74, 95% CI of 1.19-2.55). Individuals with risk genotype of both ITPR3 and NKX2.5 loci have higher risk for SLE (odds ratio=5.77). Our data demonstrate that genetic and functional interactions of ITPR3 and NKX2.5 play a crucial role in the pathogenesis of SLE.Journal of Human Genetics 02/2008; 53(2):151-62. DOI:10.1007/s10038-007-0233-3 · 2.46 Impact Factor
Article: Hosono, N., Kubo, M., Tsuchiya, Y., Sato, H., Kitamoto, T., Saito, S. et al. Multiplex PCR-based real-time invader assay (mPCR-RETINA): a novel SNP-based method for detecting allelic asymmetries within copy number variation regions. Hum. Mutat. 29, 182-189[Show abstract] [Hide abstract]
ABSTRACT: We report the development of a real-time Invader assay combined with multiplex PCR (mPCR-RETINA), an SNP-based approach that can measure the allelic ratio in copy number variation (CNV) regions of a genome. RETINA monitors the real-time fluorescence intensity of each allele during the Invader assay and detects allelic asymmetries caused by genomic duplication/multiplication in heterozygous individuals. By combining mPCR-RETINA and real-time quantitative PCR that detects total copy number, we can estimate the copy number of each allele in CNV regions, which should be useful for investigating the functional significance of allele copy number with disease susceptibilities and drug responses. Also, mPCR-RETINA can efficiently refine the detailed structures of CNV regions. Due to the combination of RETINA with multiplex PCR, mPCR-RETINA requires a very small amount of genomic DNA for analysis (0.1-0.38 ng/locus). Additionally, mPCR-RETINA has clear advantages in its simple protocol and target-specific reaction, even in nonunique regions. We believe mPCR-RETINA will provide a significant contribution to identifying functional alleles in CNV regions.Human Mutation 01/2008; 29(1):182-9. DOI:10.1002/humu.20609 · 5.14 Impact Factor
Article: Yanagiya, T., Tanabe, A., Iida, A., Saito, S., Sekine, A., Takahashi, A. et al. Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum. Mol. Genet. 16, 3017-3026[Show abstract] [Hide abstract]
ABSTRACT: Genetic factors are clearly involved in the development of obesity, but the genetic background of obesity remains largely unclear. Starting from 62 663 gene-based single-nucleotide polymorphisms (SNPs) in three sequential case-control association studies, we identified a replicated association between the obesity phenotype (BMI > or =30 kg/m(2)) and a SNP (rs2293855) located in the myotublarin-related protein 9 (MTMR9) gene in the chromosomal segment 8p23-p22. P-values (minor allele dominant model) of the first set (93 cases versus 649 controls) and the second set (564 cases versus 562 controls) were 0.008 and 0.0002, respectively. The association was replicated in the third set [394 cases versus 958 controls, P = 0.005, odds ratio (95% CI) =1.40 (1.11-1.78)]. The global P-value was 0.0000005. A multiple regression analysis revealed that gender, age BMI and rs2293855 genotype (minor allele dominant model) were significantly associated with both systolic and diastolic blood pressures. MTMR9 was shown to be the only gene within the haplotype block that contained SNPs associated with obesity. Both the transcript and protein of MTMR9 were detected in the rodent lateral hypothalamic area as well as in the arcuate nucleus, and the protein co-existed with orexin, melanin concentrating hormone, neuropeptide Y and proopiomelanocortin. The levels of MTMR9 transcript in the murine hypothalamic region increased after fasting and were decreased by a high-fat diet. Our data suggested that genetic variations in MTMR9 may confer a predisposition towards obesity and hypertension through regulation of hypothalamic neuropeptides.Human Molecular Genetics 01/2008; 16(24):3017-26. DOI:10.1093/hmg/ddm260 · 6.39 Impact Factor
Article: Miyamoto, Y., Mabuchi, A., Shi, D., Kubo, T., Takatori, Y., Saito, S. et al. A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat. Genet. 39, 529-533[Show abstract] [Hide abstract]
ABSTRACT: Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide. Epidemiological and genetic studies have shown that osteoarthritis is a polygenic disease. Here, we report that the gene encoding growth differentiation factor 5 (GDF5) is associated with osteoarthritis in Asian populations. A SNP in the 5' UTR of GDF5 (+104T/C; rs143383) showed significant association (P = 1.8 x 10(-13)) with hip osteoarthritis in two independent Japanese populations. This association was replicated for knee osteoarthritis in Japanese (P = 0.0021) and Han Chinese (P = 0.00028) populations. This SNP, located in the GDF5 core promoter, exerts allelic differences on transcriptional activity in chondrogenic cells, with the susceptibility allele showing reduced activity. Our findings implicate GDF5 as a susceptibility gene for osteoarthritis and suggest that decreased GDF5 expression is involved in the pathogenesis of osteoarthritis.Nature Genetics 05/2007; 39(4):529-33. DOI:10.1038/2005 · 29.35 Impact Factor
Article: Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction[Show abstract] [Hide abstract]
ABSTRACT: Brain infarction is one of the common causes of death and also a major cause of severe disability. To identify a gene(s) susceptible to brain infarction, we performed a large-scale association study of Japanese patients with brain infarction, using 52608 gene-based single nucleotide polymorphism (SNP) markers. Comparison of allele frequencies between 1112 cases with brain infarction and age- and sex-matched control subjects of the same number found an SNP in the 5'-flanking region of angiotensin receptor like-1 (AGTRL1) gene (rs9943582, - 154G/A) to have a significant association with brain infarction [odds ratio = 1.30, 95% confidence interval (CI) = 1.14-1.47, P = 0.000066]. We also found the binding of Sp1 transcription factor to the region including the susceptible G allele, but not the non-susceptible A allele. Luciferase assay and RT-PCR analysis demonstrated that exogenously introduced Sp1 induced transcription of AGTRL1 and its ligand, apelin, as well, indicating direct regulation of apelin/APJ pathway by Sp1. Furthermore, a 14 year follow-up cohort study in a Japanese community in Hisayama town, Japan revealed that the homozygote of the susceptible G allele of this particular SNP had significantly higher risk of brain infarction (hazard ratio = 2.00, 95% CI = 1.22-3.29, P = 0.006). Our results indicate that the SNP in the AGTRL1 gene is associated with the susceptibility to brain infarction.Human Molecular Genetics 04/2007; 16(6):630-9. DOI:10.1093/hmg/ddm005 · 6.39 Impact Factor
Article: Functional Single-Nucleotide Polymorphisms in the Secretogranin III (SCG3) Gene that Form Secretory Granules with Appetite-Related Neuropeptides Are Associated with Obesity[Show abstract] [Hide abstract]
ABSTRACT: Genetic factors are important for the development of obesity. However, the genetic background of obesity still remains unclear. Our objective was to search for obesity-related genes using a large number of gene-based single-nucleotide polymorphisms (SNPs). We conducted case-control association analyses using 94 obese patients and 658 controls with 62,663 SNPs selected from the SNP database. SNPs that possessed P < or = 0.02 were further analyzed using 796 obese and 711 control subjects. One SNP (rs3764220) in the secretogranin III (SCG3) gene showed the lowest P value (P = 0.0000019). We sequenced an approximately 300-kb genomic region around rs3764220 and discovered SNPs for haplotype analyses. SCG3 was the only gene within a haplotype block that contained rs3764220. The functions of SCG3 were studied. Obese subjects (body mass index > or = 30 kg/m(2), n = 890) and control subjects (general population; n = 658, body mass index < or = 25 kg/m(2); n = 711) were recruited for this study. Twelve SNPs in the SCG3 gene including rs3764220 were in almost complete linkage disequilibrium and significantly associated with an obesity phenotype. Two SNPs (rs16964465, rs16964476) affected the transcriptional activity of SCG3, and subjects with the minor allele seemed to be resistant to obesity (odds ratio, 9.23; 95% confidence interval, 2.77-30.80; chi(2) = 19.2; P = 0.0000067). SCG3 mRNA and immunoreactivity were detected in the paraventricular nucleus, lateral hypothalamic area, and arcuate nucleus, and the protein coexisted with orexin, melanin-concentrating hormone, neuropeptide Y, and proopiomelanocortin. SCG3 formed a granule-like structure together with these neuropeptides. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.Journal of Clinical Endocrinology & Metabolism 04/2007; 92(3):1145-54. DOI:10.1210/jc.2006-1808 · 6.21 Impact Factor
Article: Kubo, M., Hata, J., Ninomiya, T., Matsuda, K., Yonemoto, K., Nakano, T. et al. A nonsynonymous SNP in PRKCH (protein kinase Cη) increases the risk of cerebral infarction. Nat. Genet. 39, 212-217[Show abstract] [Hide abstract]
ABSTRACT: Cerebral infarction is the most common type of stroke and often causes long-term disability. To investigate the genetic contribution to cerebral infarction, we conducted a case-control study using 52,608 gene-based tag SNPs selected from the JSNP database. Here we report that a nonsynonymous SNP in a member of protein kinase C (PKC) family, PRKCH, was significantly associated with lacunar infarction in two independent Japanese samples (P = 5.1 x 10(-7), crude odds ratio of 1.40). This SNP is likely to affect PKC activity. Furthermore, a 14-year follow-up cohort study in Hisayama (Fukuoka, Japan) supported involvement of this SNP in the development of cerebral infarction (P = 0.03, age- and sex-adjusted hazard ratio of 2.83). We also found that PKCeta was expressed mainly in vascular endothelial cells and foamy macrophages in human atherosclerotic lesions, and its expression increased as the lesion type progressed. Our results support a role for PRKCH in the pathogenesis of cerebral infarction.Nature Genetics 03/2007; 39(2):212-7. DOI:10.1038/ng1945 · 29.35 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Myocardial infarction (MI) results from complex interactions of multiple genetic and environmental factors. To disclose genetic backgrounds of MI, we performed a large-scale, case-control association study using 52,608 gene-based single-nucleotide polymorphism (SNP) markers, and identified a candidate SNP located on chromosome 3p21.2-p21.1. Subsequent linkage-disequilibrium mapping indicated very significant association between MI and a SNP in exon 2 of the inter-alpha (globulin) inhibitor 3 gene (ITIH3; chi(2) = 24.88, P = 6.1 x 10(-7), 3,353 affected individuals versus 3,807 controls). In vitro functional analyses showed that this SNP enhanced the transcriptional level of the ITIH3 gene. Furthermore, we found expression of the ITIH3 protein in the vascular smooth muscle cells and macrophages in the human atherosclerotic lesions, suggesting ITIH3 SNP to be a novel genetic risk factor of MI.Journal of Human Genetics 02/2007; 52(3):220-9. DOI:10.1007/s10038-006-0102-5 · 2.46 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Through a large-scale case-control association study using 52,608 haplotype-based single nucleotide polymorphism (SNP) markers, we identified a susceptible locus for myocardial infarction (MI) on chromosome 22q12.1. Following linkage disequilibrium (LD) mapping, haplotype analyses revealed that six SNPs in this locus, all of which were in complete LD, showed markedly significant association with MI (chi2=25.27, P=0.0000005; comparison of allele frequency, 3,435 affected individuals versus 3,774 controls, in the case of intron 1 5,338 C>T; rs2331291). Within this locus, we isolated a complete cDNA of a novel gene, designated myocardial infarction associated transcript (MIAT). MIAT has five exons, and in vitro translation assay showed that MIAT did not encode any translational product, indicating that this is likely to be a functional RNA. In vitro functional analyses revealed that the minor variant of one SNP in exon 5 increased transcriptional level of the novel gene. Moreover, unidentified nuclear protein(s) bound more intensely to risk allele than non-risk allele. These results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI.Journal of Human Genetics 11/2006; 51(12):1087-99. DOI:10.1007/s10038-006-0070-9 · 2.46 Impact Factor
Article: Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients. J Hum Genet[Show abstract] [Hide abstract]
ABSTRACT: Warfarin is the most commonly used oral anticoagulant for treatment of thromboembolism, but adjustment of the dose appropriate to each patient is not so easy because of the large inter-individual variation in dose requirement. We analyzed single nucleotide polymorphism (SNP) genotypes of the VKORC1 and CYP2C9 genes using DNA from 828 Japanese patients treated with warfarin, and investigated association between SNP genotype and warfarin-maintenance dose. Five SNPs in VKORC1, 5' flanking-1413A > G, intron 1-136T > C, intron 2+124C > G, intron 2+837T > C and exon 3 343G > A, were in absolute linkage disequilibrium, and showed a significant association with daily warfarin dose of these patients. The median warfarin dose of patients with homozygosity for the minor allele was 4.0 mg/day, which is significantly higher than those heterozygous for the minor allele (3.5 mg/day) or those homozygous for the major allele (2.5 mg/day; P = 5.1 x 10(-11) in the case of intron 1-136T > C SNP). We then genotyped the CYP2C9 gene for the Japanese common genetic variant, CYP2C9*3 and, based on the genotype of these two genes, classified patients into three categories, which we call "warfarin-responsive index." The median warfarin daily dose varied significantly in this classification according to the warfarin-responsive index (2.0 mg/day for index 0 group, 2.5 mg/day for index 1 group, and 3.5 mg/day for index 2 group; P = 4.4 x 10(-13)). Thus, analysis of the combination of VKORC1 and CYP2C9 genotypes should identify warfarin-sensitive patients who require a lower dose of drug, allowing personalized warfarin treatment.Journal of Human Genetics 03/2006; 51(3):249-53. DOI:10.1007/s10038-005-0354-5 · 2.46 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Human earwax consists of wet and dry types. Dry earwax is frequent in East Asians, whereas wet earwax is common in other populations. Here we show that a SNP, 538G --> A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. The AA genotype corresponds to dry earwax, and GA and GG to wet type. A 27-bp deletion in ABCC11 exon 29 was also found in a few individuals of Asian ancestry. A functional assay demonstrated that cells with allele A show a lower excretory activity for cGMP than those with allele G. The allele A frequency shows a north-south and east-west downward geographical gradient; worldwide, it is highest in Chinese and Koreans, and a common dry-type haplotype is retained among various ethnic populations. These suggest that the allele A arose in northeast Asia and thereafter spread through the world. The 538G --> A SNP is the first example of DNA polymorphism determining a visible genetic trait.Nature Genetics 03/2006; 38(3):324-30. DOI:10.1038/ng1733 · 29.35 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: To establish 'personalized medicines' that can provide the right drug at the appropriate dose for each individual patient on the basis of genetic background, we have been building the infrastructure for a Japanese single nucleotide polymorphism (SNP) database of the genes encoding various enzymes, transporters and receptors that are involved in the metabolism, transportation and action of drugs. We have so far screened a genomic region of 4,068.3 kb, and identified a total of 7,552 genetic variations, including 6,733 SNP and 819 genetic variations of other types among 267 genes in Japanese populations. Interestingly, among the 212 non-synonymous substitutions we found, six would be considered to be nonsense mutations. In this review, we focused on the molecular features of the non-synonymous substitutions and insertion/deletion polymorphisms within coding regions detected in drug-related gene loci. The database established in this study makes us confident of achieving one of our goals, which is establishment of personalized medicine.Cancer Science 02/2006; 97(1):16-24. DOI:10.1111/j.1349-7006.2006.00142.x · 3.52 Impact Factor
Article: Yamazaki, K., McGovern, D., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D. et al. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum. Mol. Genet 14, 3499-3506[Show abstract] [Hide abstract]
ABSTRACT: The inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis, are chronic inflammatory disorders of the digestive tract. The pathogenesis of IBD is complicated, and it is widely accepted that immunologic, environmental and genetic components contribute to its etiology. To identify genetic susceptibility factors in CD, we performed a genome-wide association study in Japanese patients and controls using nearly 80,000 gene-based single nucleotide polymorphism (SNP) markers and investigated the haplotype structure of the candidate locus in Japanese and European patients. We identified highly significant associations (P = 1.71 x 10(-14) with odds ratio of 2.17) of SNPs and haplotypes within the TNFSF15 (the gene encoding tumor necrosis factor superfamily, member 15) genes in Japanese CD patients. The association was confirmed in the study of two European IBD cohorts. Interestingly, a core TNFSF15 haplotype showing association with increased risk to the disease was common in the two ethnic groups. Our results suggest that the genetic variations in the TNFSF15 gene contribute to the susceptibility to IBD in the Japanese and European populations.Human Molecular Genetics 12/2005; 14(22):3499-506. DOI:10.1093/hmg/ddi379 · 6.39 Impact Factor
Article: Mototani, H., Mabuchi, A., Saito, S., Fujioka, M., Iida, A., Takatori, Y. et al. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum. Mol. Genet. 14, 1009-1017[Show abstract] [Hide abstract]
ABSTRACT: Osteoarthritis (OA), a common skeletal disease, is a leading cause of disability among the elderly populations. OA is characterized by gradual loss of articular cartilage, but the etiology and pathogenesis of OA are largely unknown. Epidemiological and genetic studies have demonstrated that genetic factors play an important role in OA. To identify susceptibility genes for OA, we performed a large-scale, case-control association study using gene-based single nucleotide polymorphisms (SNPs). In two independent case-control populations, we found significant association (P=9.8x10(-7)) between hip OA and a SNP (IVS3-293C>T) located in intron 3 of the calmodulin (CaM) 1 gene (CALM1). CALM1 was expressed in cultured chondrocytes and articular cartilage, and its expression was increased in OA. Subsequent linkage-disequilibrium mapping identified five SNPs showing significant association equivalent to IVS3-293C>T. One of these (-16C>T) is located in the core promoter region of CALM1. Functional analyses indicate that the susceptibility -16T allele decreases CALM1 transcription in vitro and in vivo. Inhibition of CaM in chondrogenic cells reduced the expression of the major cartilage matrix genes Col2a1 and Agc1. These results suggest that the transcriptional level of CALM1 is associated with susceptibility for hip OA through modulation of chondrogenic activity. Our findings reveal the CALM1-mediated signaling pathway in chondrocytes as a novel potential target for treatment of OA.Human Molecular Genetics 05/2005; 14(8):1009-17. DOI:10.1093/hmg/ddi093 · 6.39 Impact Factor
Article: Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy[Show abstract] [Hide abstract]
ABSTRACT: To search for a gene(s) conferring susceptibility to diabetic nephropathy (DN), we genotyped over 80,000 gene-based single nucleotide polymorphisms (SNPs) in Japanese patients and identified that the engulfment and cell motility 1 gene (ELMO1) was a likely candidate for conferring susceptibility to DN, in view of the significant association of an SNP in this gene with the disease (intron 18+9170, GG vs. GA+AA, chi(2) = 19.9, P = 0.000008; odds ratio 2.67, 95% CI 1.71-4.16). In situ hybridization (ISH) using the kidney of normal and diabetic mice revealed that ELMO1 expression was weakly detectable mainly in tubular and glomerular epithelial cells in normal mouse kidney and was clearly elevated in the kidney of diabetic mice. Subsequent in vitro analysis revealed that ELMO1 expression was elevated in cells cultured under high glucose conditions (25 mmol/l) compared with cells cultured under normal glucose conditions (5.5 mmol/l). Furthermore, we identified that the expression of extracellular matrix protein genes, such as type 1 collagen and fibronectin, were increased in cells that overexpress ELMO1, whereas the expression of matrix metalloproteinases was decreased. These results indicate that ELMO1 is a novel candidate gene that both confers susceptibility to DN and plays an important role in the development and progression of this disease.Diabetes 05/2005; 54(4):1171-8. DOI:10.2337/diabetes.54.4.1171 · 8.10 Impact Factor
Article: A model of prediction system for adverse cardiovascular reactions by calcineurin inhibitors among patients with renal transplants using gene-based single-nucleotide polymorphisms[Show abstract] [Hide abstract]
ABSTRACT: The application of pharmacogenomic information to diagnostic assays is expected to improve the prediction of drug efficacy and toxicity, leading to appropriate therapeutic regimens for individual patients. Cardiovascular events are common and severe adverse drug reactions (ADRs) among transplant patients treated with calcineurin inhibitors (CNIs). We conducted case-control association studies using 50,947 gene-based single-nucleotide polymorphisms (SNPs) to identify genetic variations that might be associated with cardiovascular risk factors in 72 renal transplant recipients with CNI therapy. The overall incidence of cardiovascular events was 13.9% (10/72) among patients receiving cyclosporine or tacrolimus; arrhythmias in six patients (8.3%), ischemic heart diseases in two patients (2.8%), and heart failure in two patients (2.8%). On the basis of results of the genome-wide association studies, we attempted to establish a scoring system to predict individual risks for cardiovascular toxicity of cyclosporine and tacrolimus. Estimation of the predictive performance was carried out by the use of internal leave-one-out cross-validation test. When we combined arrhythmia, ischemic heart disease and heart failure cases as subjects with a cardiotoxicity phenotype, nine of ten ADR patients and 50 of 62 non-ADR patients were correctly classified into the respective categories using the top eight SNPs. In addition, the proportion of individuals in the control population (n=246) with scores over the cut-off (11.0%) was close to the cardiovascular ADR frequency (8.3%) among renal transplant patients in the previous clinical study. Our results open the possibility that prediction of CNI-induced cardiovascular complications can lead to better prognosis and quality of life among kidney-transplant patients, and to improved immunosuppressive regimens.Journal of Human Genetics 02/2005; 50(9):442-7. DOI:10.1007/s10038-005-0275-3 · 2.46 Impact Factor
Article: Large-Scale Single-Nucleotide Polymorphism (SNP) and Haplotype Analyses, Using Dense SNP Maps, of 199 Drug-Related Genes in 752 Subjects: the Analysis of the Association between Uncommon SNPs within Haplotype Blocks and the Haplotypes Constructed with Haplotype-Tagging SNPs[Show abstract] [Hide abstract]
ABSTRACT: To optimize the strategies for population-based pharmacogenetic studies, we extensively analyzed single-nucleotide polymorphisms (SNPs) and haplotypes in 199 drug-related genes, through use of 4,190 SNPs in 752 control subjects. Drug-related genes, like other genes, have a haplotype-block structure, and a few haplotype-tagging SNPs (htSNPs) could represent most of the major haplotypes constructed with common SNPs in a block. Because our data included 860 uncommon (frequency <0.1) SNPs with frequencies that were accurately estimated, we analyzed the relationship between haplotypes and uncommon SNPs within the blocks (549 SNPs). We inferred haplotype frequencies through use of the data from all htSNPs and one of the uncommon SNPs within a block and calculated four joint probabilities for the haplotypes. We show that, irrespective of the minor-allele frequency of an uncommon SNP, the majority (mean +/- SD frequency 0.943+/-0.117) of the minor alleles were assigned to a single haplotype tagged by htSNPs if the uncommon SNP was within the block. These results support the hypothesis that recombinations occur only infrequently within blocks. The proportion of a single haplotype tagged by htSNPs to which the minor alleles of an uncommon SNP were assigned was positively correlated with the minor-allele frequency when the frequency was <0.03 (P<.000001; n=233 [Spearman's rank correlation coefficient]). The results of simulation studies suggested that haplotype analysis using htSNPs may be useful in the detection of uncommon SNPs associated with phenotypes if the frequencies of the SNPs are higher in affected than in control populations, the SNPs are within the blocks, and the frequencies of the SNPs are >0.03.The American Journal of Human Genetics 08/2004; 75(2):190-203. DOI:10.1086/422853 · 10.93 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: We previously published a series of detailed maps of single nucleotide polymorphisms (SNPs) in the genomic regions of 209 gene loci encoding drug metabolizing enzymes, transporters, receptors, and other potential drug targets. In addition to the maps reported earlier, we provide here high-resolution SNP maps of 23 genes encoding G-protein coupled receptors in the Japanese population. A total of 300 SNPs were identified through screening of these loci; 83 in four adenosine receptor family genes, 45 in three adrenergic receptor family genes, 22 in three EDG receptor family genes, 29 in three melanocortin receptor family genes, 22 in two somatostatin receptor family genes, 21 in five anonymous G protein-coupled receptor family genes, and 78 in the others (AVPR1B, OXTR, and TNFRSF1A). We also discovered a total of 33 genetic variations of other types. Of the 300 SNPs, 132 (44%) appeared to be novel on the basis of comparisons with the dbSNP database of the National Center for Biotechnology Information (US) or with previous publications. The maps constructed in this study will serve as an additional resource for studies of complex genetic diseases and drug-response phenotypes to be mapped by linkage-disequilibrium association analyses.Journal of Human Genetics 02/2004; 49(4):194-208. DOI:10.1007/s10038-004-0133-8 · 2.46 Impact Factor
Top Journals
RIKENВако, Saitama, Japan
Osaka Rosai HospitalŌsaka, Ōsaka, Japan
The University of Tokyo
Tōkyō, Japan
- • Center for Human Genome
- • Institute of Medical Science


text:
HRC Goes to Camp
July 22, 2014 by Candace Gingrich, Associate Director, Youth and Campus Engagement Program
It's a summer ritual: youngsters heading off to camp. For some members of Generation Equality, going to camp means hosting an open-mic night instead of sitting by a campfire, and learning to build plans for change instead of sit-upons.
Every summer for the last eight years, Campus Pride, the national LGBTQ & ally college student educational organization, has hosted held Camp Pride Summer Leadership camp, an intensive gathering for queer students and school organization advisers. This year, campers included more than 120 students, faculty & staff from a wide array of higher education institutions, including Historically Black Colleges and Universities (HBCU).
Campers learned about self-care, intersectionality, working for safer, more inclusive campuses, and social justice activism. They heard from an amazing array of speakers, including Mandy Carter, Mara Keisling, Rev Dr Jamie Washington, Diego Sanchez and Janet Mock.
The Human Rights Campaign Foundation was once again a sponsor of Camp Pride this year, sponsoring Friday night's dinner. I had the opportunity to attend some Friday activities and presented the "Equality Talks: Using Everyday Conversations to Advance LGBT Equality" workshop to very engaged campers.
Camp Pride Leadership Camp is just one of the many events that Campus Pride offers to Generation Equality. Check out their upcoming schedule of regional LGBT-Friendly College Fairs held in partnership with GLSEN.
I know full equality will come sooner thanks to the dedication & energy that these campers and advisers bring to the movement.
I hope that I see some of them among this fall's HRCU Internship cohort!
Top Posts
Time to Celebrate: National LGBT Pride Month
June 1, 2015
Frequently Asked Questions about the Upcoming Marriage Equality Case at the U.S. Supreme Court
April 24, 2015
Be Ready to Rally on Decision Day
June 15, 2015
What's at Stake: Potential for Nationwide Marriage Equality Following Supreme Court Ruling
June 5, 2015
Watch: HRC Answers Your SCOTUS Questions
June 19, 2015

subset: commoncrawl


text:
Neptune's Treasure
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Beach
- Free High-Speed Internet
- Restaurant
- Bar/lounge
- Beverage Selection
- Free parking
Travelers also recommend:
TravelPod Member ReviewsNeptune's Treasure Anegada
This place is iconic, its just down from the infamous Anegada Reef Hotel; however, the atmosphere is so relaxed you can almost feel like you a guest in the proprietor's house. The bar works on the honor system, simply put you pay for what you drink and put the money in a jar. The Lobster is the best. To this day, I have never eaten a lobster so sweet than from Neptune's. It is so fresh you actually go down on the dock and select the gut you want. Captains and crew always get a free lobster at Neptunes fro bringing their charter guests ashore.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Neptune's Treasure Anegada
Travel Blogs from Anegada
Exploring the British Virgins.
... is a fascinating geological and delightful spot called The Baths. It comprises of spectacular granite boulder formations which look like a bag of them has just been emptied out in a pile, and in total contrast to the rest of the Island. It's beauty lies in the many emerald sea pools and grottos with white sandy beaches and bottoms. The water is gin clear, the boulders and aquatic life under as clear as above. Dinghies and yachts are not allowed in ...
Day 3 - Virgin Gorda (Gorda Sound - Prickly Pear)
... just amazed at how normal every one in this band is. It was like sitting next to ... anyone ... except that anyone just happens to be a freaking amazing musician who brings enormous amounts of happiness and joy to so many people. After hoping off the tender I took the opportunity to grab a selfie. I then proceeded to wander the ground photographing anything and everything ... Oh look .. There's a lizard ...... The Sandbox was the beach bar there, however the ...
... stuff. I totally don't want to do that. I doubt continuing the study. As much I love Wageningen.. That's not what I want to do in the future. Well, I will see what's coming out of this year. I have many opportunities. Sometimes they are just not recognisable. Just 2 weeks left, looking forward to my peeps at home! Would love to stay longer, though.. Just realised that I reported some of the stuff already in the last entry. Now.. Doppelt hält besser ...
Still here!
... do the whole trip in one go ( I can't tell you how much I'm looking forward to the 30 hours smashing into the wind and waves) we will hopefully be in Antigua sometime Saturday afternoon. I think a few larrrrrge rums will be needed when we get there ! When we get back we will only have a week and a half before we come back to the uk. I can't believe how fast this three months have gone. I can't wait to see my boy though, I've missed him a lot. ...
Virgin Islands
... even starting to get nippy in the evenings!!! More to follow in the next few days. Bye bye xxx TIM............ Yes great to be back in the BVIs, sheltered sailing which keeps Luce happy, although the payoff is being surrounded by every charter catamaran in the western world! Managed to watch the rugby at a great beach bar yesterday full of drunken expats, great game and all a lot of fun! Got a bit ****** off with getting a small hole in the fender on my new dinghy ...


text:
Navy Vessels
New Zealand's New Navy Vessel Ready for SeaTrials
The first vessel in the New Zealand government's $500 million navy upgrade has come off its slipway in a Dutch shipbuilding yard. It will be used to carry troops and cargo, allowing them to be disembarked at sea. It has been built as part of Project Protector, with seven vessels planned. Officials say that it will be followed by sea trials, with the vessel due in New Zealand by the end of the year. source: Radio New Zealand
USS Simpson Trains 5 Countries in Anti-piracy
Guided-missile frigate USS Simpson completes two days anti-piracy training exercises in Gulf of Guinea. Participating in Obangame Express, a maritime exercise aimed to improve cooperation amongs participating nations, USS Simpson acted as a boarding vessel with role players and trainers for teams from five countries - Cameroon, Gabon, Ghana, Sao Tome and Principe, and Spain. Simpson also sent a boarding team to a Nigerian navy vessel, the patrol cutter NNS Nwamba
Dockwise Awarded MSC Contract
Dockwise Ltd., has been awarded a contract by U.S. Military Sealift Command for the use of one of its specialized open stern vessels for offshore operational design tests. The contract is due to be executed late 2008 and has a gross value in excess of $25m, including the costs of modification of the vessel. This is the fourth time Dockwise will provide one of its large heavy transport vessels to the U.S. Navy for offshore operational tests
Seminar on Fire Testing for SOLAS and Navy Vessels
A Seminar on Fire Testing for SOLAS and Navy Vessels: New Test Procedures and Material Approval Process will be held Wednesday, December 7, 2011. Sponsored by ASTM Committee F25 on Ships and Marine Technology, the workshop will be held at the Marriott Waterside Tampa in Tampa, Florida, in conjunction with the December standards development meetings of the committee. Objective ASTM F25 Committee presents a one day Seminar "Fire Testing for SOLAS and Navy Vessels: New
Today in U.S. Naval History: February 7
Today in U.S. Naval Hostory - February 7 1800 - USS Essex becomes first U.S. Navy vessel to cross the Equator. 1815 - The Board of Naval Commissioners, a group of senior officers, is established to oversee the operation and maintenance of the Navy, under the direction of the Secretary of the Navy. 1955 - Seventh Fleet ships begin evacuation of Chinese nationalists from Tachen Islands 1965 - In response to a Viet Cong attack on barracks area at Pleiku, South Vietnam
North Korea: Action Against South's Navy Possible
North Korea's military warned on Friday of "unannounced targeted strikes" against South Korea's navy, accusing the South of violating its territorial waters off the peninsula's west coast, the scene of deadly naval clashes in the past. Pyongyang's warning came during the annual crab fishing season, which runs until June in the waters off the west coast of the Korean peninsula. Naval forces from the two Koreas clashed during the same month in 1999 and 2002
China Wages Territorial Battle With Australia
China lodged a complaint with Australia after three Australian naval vessels moving through the Taiwan Straits were challenged by the Chinese navy, a spokesman for Australia's foreign affairs minister said. A Chinese navy vessel told three Australian ships moving through the straits earlier this month that they were in territorial waters. However, the Australian vessels said they were exercising their right to free navigation in accordance with the laws of the sea and continued.
Northrop Grumman Wins Contract to Supply Navigation
Radar Sets for U.S. Navy Submarines Northrop Grumman Corporation has been awarded a contract by the Naval Sea Systems Command to supply navigation radar sets and associated systems engineering for 10 U.S. Navy submarines. The company's Sperry Marine business unit will deliver AN/BPS-16(V)4 navigation radar sets for six Virginia-class attack submarines and four guided-missile submarines. Deliveries will begin in
This Day in Naval History - Feb. 07
From the Navy News Service 1800 - USS Essex becomes the first U.S. Navy vessel to cross the equator. 1815 - The Board of Naval Commissioners, a group of senior officers, is established to oversee the operation and maintenance of the Navy under the direction of the Secretary of the Navy. 1955 - Ships from the 7th Fleet begin the evacuation of Chinese nationalists from the Tachen Islands. 1965 - In response to a Viet Cong attack on a U.S
This Day in Naval History – July 22
1802 - Frigate Constellation defeats 9 Corsair gunboats off Tripoli. 1905 - Body of John Paul Jones moved to Annapolis, MD for reburial. 1953 - U.S. ships laid down heavy barrage to support UN troops in Korea 1964 - Four Navy Divers (LCDR Robert Thompson, MC; Gunners Mate First Class Lester Anderson, Chief Quartermaster Robert A. Barth, and Chief Hospital Corpsman Sanders Manning) submerge in Sealab I for 10 days at a depth of 192 feet, 39 miles off Hamilton, Bermuda
Chinese Ships Spotted off Alaska
Five Chinese Navy ships are sailing in international waters in the Bering Sea off Alaska coast, coinciding with President Barack Obama's visit to the the U.S. state. US defence officials have spotted three Chinese combat ships
MN 100: Dometic Marine
The Company: Dometic Marine is an engineering leader of innovative products for the global marine industry and offers a large worldwide sales and service network. Products include air conditioning, refrigeration, ship-wide ventilation, air purification, water purification, and sanitation
India, Australia Begin First Joint Maritime Exercises
India and Australia have commenced the first bilateral maritime exercise, Ausindex15, in Visakhapatnam, India, strengthening defence cooperation between the countries. Building on the personal relationship of Prime Minister Modi and Prime Minister Abbott, the Minister for Defence
AUSINDEX15 a Success
The inaugural bilateral maritime exercise between India and Australia, AUSINDEX15, has concluded in Visakhapatnam, India. The activity brought together ships and aircraft from both countries to strengthen defence co-operation under the Framework for Security Cooperation announced
ASRY in Maritime Deal with Relay
UK-based engineering firm signs service agreement to provide direct services to vessels in ASRY, expanding the list of the yard's onsite specialist contractors. ASRY, the leading ship and rig repair yard in the Arabian Gulf, has signed a specialized Services Agreement with Relay
Russia, China Hold Joint Naval Exercises
The second stage of Russia-China "Joint Sea 2015" maritime exercises are taking place on June 8-11 in Russia's Far Eastern Primorsky Territory, according to a statement from the Russian Defense Ministry's Eastern Military District press service.
Malaysian Navy Negotiating with Tanker Hijackers
Orkim Harmony located with crew, cargo safe; Malaysian navy negotiating with pirates onboard. A Malaysian naval vessel has made contact with the pirates onboard hijacked tanker Orkim Harmony and is trying to persuade them to surrender, a maritime official said on Thursday.
Indian Warships Visit Cambodia, Thailand
In pursuit of India's 'Look East' and 'Act East' policy, the Indian Navy's Eastern Fleet ships under the command of Rear Admiral Ajendra Bahadur Singh, VSM, Flag Officer Commanding Eastern Fleet (FOCEF)
US Navy Promotes Security in South China Sea
The U.S. Navy reports its Arleigh Burke-class guided-missile destroyer USS Lassen (DDG 82) has continued to patrol the South China Sea since the end of May 2015 in support of security and stability in the region, a major sea line of worldwide communication for commercial shipping traffic
Thousands Rescued At Sea Near Libya
Around 2,700 migrants were rescued from 13 boats near the coast of Libya on Wednesday, Italy's coastguard said. A German navy vessel and a search and rescue ship deployed by medical charity Medecins Sans Frontieres participated in the rescues along with the Italian navy and coastguard.
Up to 40 Migrants Feared Drowned off Libya
Up to 40 African migrants were feared drowned after their inflatable boat sank near the Libyan coast, survivors told the United Nations refugee agency on Thursday after reaching Italy. "They said between 35 and 40 people died on Wednesday morning," said Carlotta Sami
GE Powers Next Generation of UK Navy Ships
GE Marine informs it has been awarded a contract to supply electrical power and propulsion to the Type 26 Global Combat Ships for the U.K. Ministry of Defense (MOD). According to GE, the marine industry often faces the challenge of bringing continual innovation to vessels without
New DMRs for USN Destroyers, Submarines under Construction
The U.S. Navy has ordered 56 AN/USC-61(C) Digital Modular Radios (DMRs) and related equipment from General Dynamics. The newly built DMR radios will be capable of using the Mobile User Objective System (MUOS) waveform, the digital dial tone needed to make voice calls to the U.S
Bolidt showcases strength at Europort
Bolidt has been selected to supply decking solutions across a wide range of Dutch maritime projects that encompass the entire range of industry sectors. The Dutch flooring and decking specialist will be showcasing its comprehensive range of synthetic decking solutions at Europort 2015.
White House: No Threat from China Navy Ships in Bering Sea
The Pentagon has not detected any threatening activity from the Chinese navy vessels in the Bering Sea, the White House said on Wednesday. "Based on their analysis they have not detected any sort of threat or threatening activities," said White House spokesman Josh Earnest


text:
the city of fulton pd knew that deputy would days before...
Posted in the North-Hollywood Forum
1 - 1 of 1 Comments Last updated Jul 30, 2011
#1 Jul 30, 2011
There is city in New York called Fulton in which a bizzare story about a family's claims on incest began years ago. many got involved in it and there to this day has been a bizarre strong of cop killings and others that tell the story the family was telling.
Near the beginning of July the CITY OF FULTON POLICE dept called me about some "RED COP" letters that I had sent through the post office unopened. Those letters where my limited outreach to get the info out that it was highly likely based on other cop killing info had gotten prior to the death that this would happen again.
The officer who called me has been established in all of this activity and laughed again and I knew something "was close" as I also said in front of 3 of them who confronted me that day. my words were "I'm close to something" "it's an ONEIDA city police officer" and this was now strongly based this one Fulton officers attitude that day. I agreed to stop sending the letters out and went home and to my I won;t say shock but still expectation just days later an ONEIDA DEPUTY was shot dead. This is the 6th officer to die in this very bizarre story all of them are linked. According to those who were successful in labeling me as a "sexual Predator" NOT by the law but rumors and "crazy." There will be a total of 7 cops who will die by the time "HE" and "THEY" are done as well as a few more civilians. I WILL NOT RECANT MY CLAIMS and this IS my real name. You have to see the whole story and how it was built first before passing judgement on me. I can prove what I claim, I just have no money or resources. "HE" claims he wrote this story and its his NOT mine.
Tell me when this thread is updated:Subscribe Now Add to my Tracker
Add your comments below
North-Hollywood Discussions
|Last By
|107-year-old Holocaust survivor, Jehovah's Witn... (Nov '12)
|11 hr
|The 25 Most Dangerous Cities in the U.S. Are Mo... (Nov '10)
|12 hr
|The Donald
|One pair of minibout zep loubotuin pumps size 40 (Nov '08)
|17 hr
|Frasier Lufganglion
|Michael Jackson's Robert Burns songs to be rele... (Jan '12)
|17 hr
|Tuttut SFS
|Alarming Tale of L.A. Sheriff's Officers
|Aug '15
|Ola Amgos (Aug '12)
|Aug '15
|WE HATE MEXICANS IN North Hollywood, Kids hated... (Dec '12)
|Aug '15
Find what you want!
Search North-Hollywood Forum Now
Copyright © 2015 Topix LLC


text:
Square Wedding Cake With Chocolate Fondant Bow
- Uploaded By loree001
- 2007-11-26 19:44:37
This cake was chosen by the bride on Cakecentral, (JENN123). Added the fleur-de-lis details to cover the corners of the plastic divider plates at the request of the wedding planner.
MCook Says... 7 years ago
Beautifully done!
cakes21 Says... 7 years ago
So elegant
Login To Leave A Comment


text:
Cute seaside cottage set in prize-winning gardens
From $85 / night
Description from the owner
Description from the owner
Bedrooms: 2/
Bathrooms: 1/
Sleeps: 5/
Type: Cottage
This small comfortable cottage is only 1km from Plougasnou's clean sandy beach and although surrounded by fields and gardens you are only 10 minutes walk from the village shops and amenities. The cottage is one of 3 holiday rentals created from the 200 year old farm buildings of Kerdalidec which are set amongst beautiful, prize-winning gardens. The cottage has its own private garden with BBQ and garden furniture and direct access to the huge shared garden where you will find a play-area for children and also animals for them to feed...little black sheep, chickens, ducks and rabbits.
The cottage has an open-plan living area with the kitchen/dining ...Read more
About the owner
About the owner
Deborah G.
Deborah G.
- Response rate: 100%
- Response time: A few hours
- Calendar updated: 2 days ago
Overall rating:
Additional Location Information
The cottage is situated just outside the seaside village of Plougasnou in Brittany. It is surrounded by fields in a very quiet and peaceful spot. The village centre is only 10 minutes walk and you will find restaurants and shops here. Our gardens have won many prizes in the local garden competition.
More About This Location
Beach or lakeside relaxation


text:
Brazil's Straw Hat project helps women leave abusive situations
A look at Switzerland's entrenched gun culture
28 Jul 2013 11:20 GMT | Politics, US & Canada, Syria, United States
The Syrian opposition has wrapped up its meetings with John Kerry, the United States' secretary of state, at the United Nations in New York.
If you want to raise the prospect of a political solution you have to convince the regime they don't have a chance of a military victory... We have supported every single political initiative.
Najib Ghadbian, Syrian National Coalition
For the first time since the conflict started opposition leaders came to brief the ambassadors of the UN's Security Council, saying they were prepared to attend peace talks. The meeting was a first - but has it achieved anything?
Diplomats say that it is still far from certain that talks in Geneva will take place. But they say it is a little more likely now.
Syrian National Coalition leader Ahmed al-Jabra has said the situation is desperate and called for the US to arm the rebels quickly and to push harder for a political settlement.
The SNC leader has also reiterated that there will be no peace talks with the Syrian government, if its forces continue to kill civilians.
Meanwhile, the United Nations says it has reached an agreement with Syria on an inquiry into the suspected use of chemical weapons.
The meeting comes as the US plans to boost military aid to the Syrian rebels to gain momentum.
Last week the US' highest ranking military officer gave the most detailed assessment yet of Washington's options to end the conflict in Syria.
If we see more agreement on an international level and a stronger faith in politics then we are going to see more consensus on the ground in Syria, less casualties and more space open for political process and hopefully heading towards a solution.
Rim Turkmani, 'Building the Syrian State'
But the chairman of the joint chiefs of staff, General Martin Dempsey, warned that any military intervention would be costly and uncertain.
And, he said, once the US took action, deeper involvement would be hard to avoid.
General Dempsey assessed the risks and benefits of five military options: Arming and training opposition troops would cost about $500mn a year. Limited air strikes, establishing a no-fly zone, creating buffer zones inside Syria, and controlling the government's chemical arms would each cost around $1bn a month.
But what can the SNC meetings achieve on the ground? Is a political solution to end Syria's ongoing conflict still possible? And what are the risks of direct US military involvement in the Syrian conflict?
Inside Syria, with presenter Hazem Sika, discusses with guests: Najib Ghadbian; a representative of the Syrian National Coalition at the UN; retired brigadier General Mark Kimmitt, a former US state department official under President George W Bush. He also served as deputy assistant secretary of defense for the Middle East; and Rim Turkmani, a member of the political office of 'Building the Syrian State' - a political movement that calls for a democratic transition in Syria.
"I'm concerned that the progress being made by the regime on the ground is such to provide a disincentive for them to want to negotiate. Until there is some sort of military setback on the part of the Syrian regime, until Assad believes there is a reason to negotiate I believe that he is just going to continue to capture his gains and without providing support to the rebels he could well continue this military operation to the point where he sees absolutely no reason to negotiate."
- Mark Kimmitt, a former US state department official
Source: Al Jazeera
What are the risks, costs and consequences of direct US military involvement in the Syrian conflict?
Politics, US & Canada, France, Iraq, Syria
Although the carnage has slipped under the radar, Syria's destiny will define the future of the Arab revolutions.
Politics, US & Canada, Afghanistan, Egypt, Iraq
Content on this website is for general information purposes only. Your comments
are provided by your own free will and you take sole responsibility for any direct
or indirect liability. You hereby provide us with an irrevocable, unlimited, and
global license for no consideration to use, reuse, delete or publish comments, in
accordance with Community Rules & Guidelines and Terms and Conditions.
Tackling the refugee crisis, Iran nuclear deal, and helping rape victims push candidates towards the coveted prize.
War & Conflict, Human Rights, Norway
Joining the West, Reykjavik imposed sanctions on Russia over Ukraine, but now its fishermen are paying the price.
Politics, Business & Economy, Iceland
The illicit kidney trade in South Asia has exploded as brokers use social media to find donors.
Health, Business & Economy, India
Twice the size of Paris, the open-air Iwahig Prison and Penal Farm offers a unique approach to reforming criminals.
Prisoners, Philippines, Crime
Follow the incredible journey of Asadullah Rahman, the youngest inmate to be held at Guantanamo Bay.
War & Conflict, Afghanistan, Taliban
People & Power investigates India's Hindu fundamentalists and their influence on the country's government.
India, Politics, Human Rights
101 East explores why over 300 Australian children are abducted by a parent and taken overseas every year.
Australia, Asia, Law
Al Jazeera World looks at the neutral nation's entrenched gun culture and the debate about the right to carry weapons.
Gun violence, Europe, Arts & Culture


text:
Medical Clinics, Los Angeles, CA
FPA Women's Health - Torrance
3655 Lomita Blvd, Suite 400, Torrance, CA 90505
FPA Women's Health - Downey
8635 Firestone Blvd, Ste 100, Downey, CA 90241
FPA Women's Health - Los Angeles
12304 Santa Monica Blvd, Ste 116, Los Angeles, CA 90025
- FPA Women's Health - Mission Hills
- Personal & Confidential Care For Women Since 1969. Call Us Today.
- 10200 Sepulveda Blvd, #200, Mission Hills, CA 91345
- Sunset Walk-In Healthcare and Occupational Medicine Clinic PC
- VIP Treatment on the Sunset Strip
- 9201 W Sunset Blvd M-155, West Hollywood, CA 90069
View Website
Barlow Pulmonary Medical Group
2000 Stadium Way, Los Angeles, CA 90026
3.7 Miles
"this is the only facility that was able to get my mom off the vent. the pulmonologists are p...">
STD Testing Long Beach
4972 W Pico Blvd Ste Tba, Los Angeles, CA 90019
2.8 Miles
"Excellent experience at the test center. Will be using these services if needed in the futu...">
STD Testing Los Angeles
1400 S Grand Ave Ste 612, Los Angeles, CA 90015
1.9 Miles
"It was very comfortable, I didn't feel nervous, the entire experience was quick and painless">
Advanced Hypnosis Of America
4647 Kingswell Ave Ste 156, Los Angeles, CA 90027
4.3 Miles
"caring service, highly confidential, comfortable and nurturing environment, client's care co...">
STD Testing Los Angeles
4972 W Pico Blvd, Los Angeles, CA 90019
2.8 Miles
"It was a relatively easy process and they were very professional and efficient. The test its...">
STD Test Express Los Angeles
Serving Los Angeles, CA
1.9 Miles
"Test center was very professional. Staff was very compassionate and friendly.">
STD Testing Long Beach
8737 Beverly Blvd Ste 401, Los Angeles, CA 90048
5.4 Miles
"Very good. No wait. Great experience.">
STD Testing Los Angeles
8737 Beverly Blvd Ste 401, Los Angeles, CA 90048
5.4 Miles
"It was speedy and efficient. I didn't wait long at all!">
Glendale NON Profit STD Testing
801 S Chevy Chase Dr Ste 100, Los Angeles, CA 91205
7.4 Miles
"What can I say: great customer service, low cost, and quick results. Try them out.">
USA Vein Clinics
7901 Santa Monica Blvd Ste 209, West Hollywood, CA 90046
5.0 Miles
"The doctors and staff were very polite and helped me through the whole process. I had no dis...">
Ochs Hair Institute Medical Clinic
8817 W Olympic Blvd Ste 204, Beverly Hills, CA 90211
5.1 Miles
"I wnated to share my hairline close up photo with you">
STD Testing Long Beach
465 N Roxbury Dr Ste 715, Beverly Hills, CA 90210
6.6 Miles
"Very professional, never even took a seat to wait since they had called me in immediately. T...">
STD Testing Long Beach
214 N Central Ave, Glendale, CA 91203
7.8 Miles
"Nice, Prompt, no wait time at all. I was back at work in less than 30 minutes">
STD Testing Los Angeles
465 N Roxbury Dr Ste 715, Beverly Hills, CA 90210
6.6 Miles
"very pleasant. The staff was prompt in their actions to provide me the tests.">
STD Testing Long Beach
1260 15th St Ste 620, Santa Monica, CA 90404
10.9 Miles
"The technician who drew my blood was very polite, nice, and excellent. The lady at the desk ...">


text:
For Immediate Release: 6/6/2013
|Summer Activity Calendar Released by MCPS As Part of the "Be Active Montgomery!" Initiative
Montgomery County Recreation, in partnership with Montgomery County Public Schools (MCPS), announces the creation of an online Summer Activity Calendar for children. Much like a summer reading list, the calendar lists games, activities and fitness challenges for kids to mark off each day of the summer break.
The calendar was developed by physical education instructors at MCPS, and can be accessed on the "Be Active Montgomery!" website. In addition to the calendar, the website features weekly wellness tips, opportunities for recreational activities in Montgomery County, wellness resources and suggestions for pool games, outdoor neighborhood games and other fun summer activities.
The Summer Activity Calendar is one of the efforts of the "Be Active Montgomery!" initiative introduced by County Executive Ike Leggett. Acknowledging the problem of childhood obesity in the Washington, D.C. area, the campaign is designed to make residents aware that a healthier lifestyle can be achieved in incremental steps. Ideally, kids should be active 60 minutes each day according to the U.S. Department of Health and Human Services website, www.health.gov. But, even 10 minutes is better than nothing, and the calendar is full of quick daily games and activities encouraging children to get off the couch and be active.
"The message of the 'Be Active Montgomery!' campaign is that it is not necessary to jump into a whole fitness regime but encourages just doing something fun and active every day," said Leggett. "We hope, with the kick off of this new initiative, children will realize how easy it is to include physical activity in their daily schedules."
The "Be Active Montgomery!" campaign officially kicks off on Saturday, June 8 from 10 a.m. to 2 p.m., at the South Germantown Recreation Park. The field day features obstacle courses and games, sport and fitness demonstrations, active performances and mini-classes and interactive wellness booths for all ages. Participants in the fitness challenge will receive free admission to the miniature golf course at the South Germantown Recreation Park and the Germantown Outdoor Pool located at 18905 Kingsview Drive.
For more information, call 240-777-6821 or visit http://www.montgomerycountymd.gov/rec.
|Release ID: 13-171
Media Contact: Susan Hoffman 240-777-6962 or Elizabeth Gallauresi301-793-2928
Return to News Releases


text:
Real, cycle-ending change can look like not just making a one-time intervention, but transforming the current system into a new vision. When this happens, I believe communities are not simply ending cycles of violence; rather, they are transforming them into cycles of education, peace and prosperity.
Like most women worldwide, I have a very ordinary mom. She is not famous, she is not spectacularly rich, she has never invented anything that she had to patent, and she's never saved anyone's life by performing emergency CPR or the Heimlich maneuver. So yes, she was ordinary. And yet she was -- and is, at the age of 73 -- a superhero.
But even now, 50 years later, she says that the time she spent in Africa "gave me a formation ... and left me with a sense of all the things you can do as one person." Of all her life experiences, she says, this one -- caring for families half a world away from her home country -- "probably marked me the most."
Watching my mother and grandmother taught me so much -- seeing them nurture people and animals showed me, through their actions, what mattered most. They made so many sacrifices for our family, and they set the standard. They inspired me from childhood to volunteer and advocate for those less fortunate.


text:
You may also like
Rate Dr. Michael B. Rho
Dr. Michael B. Rho's Ratings
Dr. Rho is very professional, easy to talk to and thorough. I ended up requiring a major surgery for a serious life threatening condition, and it was due to Dr. Rho's recommendation for more investigation of the issue. I am forever grateful to him for his thoroughness and skills.
Was this rating useful? 0 [[ userState['ratings'][859846].votes_count ]]
Dr. Rho is very skilled and personable and extremely professional. However, the staff was not consistently pleasant with me, and I had long waits on 2 occasions, only to be rushed through my appointments anyway. At the last appointment I was referred to the main Boston infirmary for surgery which I thought at the time was elective - but then I felt pushed out by the Doctor. I also saw some of the charges for my visits on my insurance statement and they were considerably higher than other specialists I've been to. We're all in life to make a living and I understand this, but I suggest that this organization should be less aggressive about revenue and more concerned with patient care and accomodating their needs. That said - Mass Eye & Ear doesn't have the reputation it does for nothing. Highly, highly skilled physicians.
Was this rating useful? 0 [[ userState['ratings'][859845].votes_count ]]
Dr. Rho is very thorough and caring. i would recommend him to anybody.
Was this rating useful? 0 [[ userState['ratings'][859844].votes_count ]]
Find a Doctor by Specialty
Featured Articles
You may also like
Top Ear Nose and Throat (ENT) Doctors
#1 of 4
#2 of 4
#3 of 4
#4 of 4


text:
Wednesday, February 15, 2012
© Copyright 2015 Clayton News Daily
Hoss is wonderful big gray and white Domestic Shorthair. He is approximately 3 years old and he has been neutered and fully vaccinated. Hoss was found at Animal Control, and even under such stressful conditions, his sweet, wonderful personality just shined right through. CCHS staffers were immediately entranced by this angel, but before the paperwork could even be filled out, it was noticed that Hoss had an injured foot. So, he was immediately taken to the vets to address the injured foot, but on the way, he seemed to become weak and extremely quiet. Once at the vet, he was quickly checked out and found to be severely underweight and anemic. Apparently, his time "on the streets" had taken a heavy toll on his health. Poor Hoss received an immediate blood transfusion, followed by several days of rest at the vet's office. Now, fat, happy and very healthy, Hoss has made a full recovery. He is very, very sweet and loving. He gets along with everyone he meets, and just blends in with all the other cats at the CCHS shelter. Simply put, there is nothing but good that can be said about this sweet guy. Anyone interested in adopting Hoss, should contact Robin at 770-478-7531. To see other adoptable CCHS animals, please visit our Petfinder pages at www.petfinder.com and use our 30236 zip code for your search.
More like this story
- Pet of the Week - Hoss ( April 22, 2013 )
- Pets of the Week - Dec. 18, 2008 ( December 18, 2008 )
- Bijou ( October 22, 2009 )
- Pets of the Week - Aug. 14, 2008 ( August 14, 2008 )
- Steele ( November 11, 2009 )


text:
I'm posting at a number of spots about NEW POP LIT's appearance at the famed Detroit urban street fair, the "Dally in The Alley."
Our main report is right here.
I'm posting at a number of spots about NEW POP LIT's appearance at the famed Detroit urban street fair, the "Dally in The Alley."
Our main report is right here.
Our task at NEW POP LIT is to cover literary issues in a way no one else will cover them. We try to look behind the facade of the acceptable narratives to present you what's really happening, and what individuals within the book community really think.
See, for instance, our interview with Daily Beast book reviewer Tom LeClair: http://newpoplit.com/2015/08/31/leclair-on-franzen/
LeClair is as outspoken as any book critic can be—calling out "middlebrow cheerleader(s)" who engage in "critical irresponsibility."
Surely "Big 5" publishing has something of a symbiotic relationship with lit-establishment organizations, publications, and writers. To what extent does this influence the nature of book reviews? Especially when the novel being reviewed is as heavily promoted as is Purity by Jonathan Franzen?
These are questions which need to be asked and answered.
Why has the American public embraced political candidates Donald Trump and Bernie Sanders? It shows a rejection of the "business-as-usual" status quo political establishment.
The same phenomenon should be taking place in the world of literature, which badly needs a shakeup and shakeout.
Ever look at yahoo news or other online information sources? Entire staffs of editors are assigned to cover movies, music, and sports. Almost NO ONE covers the book world, which as a topic of interest has disappeared. Big-selling authors are out there, the likes of George R.R. Martin. (Or even lit-establishment novelist Jonathan Franzen.) They have ZERO personality—and in truth aren't very good writers. There's little reason to cover them.
This tells me that the publishing establishment anchored in New York City and their well-trained p.r. mavens have been failures. They're doing everything wrong.
We at NEW POP LIT are confident or naive enough to believe we can do better.
In contrast to the "go-along-to-get-along" weasels of establishment politics, actual human beings like Sanders and Trump are a welcome difference.
It's also time to move on from the conformists of establishment literature.
(See NEW POP LIT's report on the new Jonathan Franzen novel, here.)
As editor at NEW POP LIT (www.newpoplit.com) I'm not getting enough submissions of short fiction which try to hit what I'm truly after. Any story is a mix of elements. Plot; character; description; literary style. I'm looking for a completely different mix of elements—stories which are as stripped-down as a Raymond Carver story but with a whole hell of a lot more color and plot.
We want to hit the unwary reader right from the get-go: boom, boom, boom. Get the reader immediately into the story. Short paragraphs. Immediate action. Then, as the fast pace progresses, reveal character and meaning, much of which by necessity will be implied or between the lines.
I want to present stories which can be handed to ANYONE and be appreciated and liked. The days of an isolated literary clique writing for themselves should be OVER. Kill that period. Reinvent the art form. Create unparalleled excitement. Experiment and experiment with the elements until you produce something that rocks.
WRITERS and other literary folk need to step back and adopt a historical perspective about where literature and publishing are headed. In the universe, though there are overarching truths, change is a constant. Publishing is in the midst of drastic change. The goal of NEW POP LIT is to gain a position from which to participate in that change. We have enough time to put together the right kind of vehicle to drive through the current and approaching noise and chaos of where the culture is now.
How are things in the world of New York City "Big Five" conglomerate publishing?
We at NEW POP LIT took a break from creating an alternative long enough to interview John Colapinto, staff writer at The New Yorker. What he has to say about his own difficulties is revealing. You'll not read a stronger interview anywhere.
See http://newpoplit.com/2015/07/22/exclusive-john-colapinto-interview/
Read the story and interview—then let us know what you think.
Yes, at the various NEW POP LIT entities we're running an entire week of baseball celebration.
We begin with the new lead story at our main site, by Tom Tolnay, "Baseball Is Truth, Truth Is Baseball"
Next, we're running a poll at our Detroit Literary blog, asking which was the best Detroit Tigers baseball team of all time? The choices given are the city's four world championship campaigns. See
Finally, for hard-core baseball readers, here's a link to info about an essay about the great American game which I wrote for North American Review way back in 1994, during the infamous baseball strike. The essay is titled, "The Last Day of Baseball."
Not the last day of baseball after all, it turned out—which allows us to engage in this 2015 celebration.


text:
The Old Spaghetti Factory
160 2nd Ave N, Nashville, TN 37201
- This venue is wheelchair accessible but please enter in the front of the building.
- Guests will find street or garage parking; fees vary and are typcially an average of $13.00/car.
160 2nd Ave N, Nashville, TN 37201
The rustle of silks and feathers under muted conversation was probably the last thing heard by the tragically and unexpectedly deceased at the Annual Billionaires Club Masquerade Ball. With a mystery under each feathery façade, unmasking the killer may be quite a challenge. It's up to you to determine which partygoer is guilty, bring this crime to justice, and save the party!
Attend the Billionaires' Club Annual Masquerade Ball and help get this soiree back on track by trading clues with your guests, gathering information, and solving the crime before the masked menace gets away! Evening wear, ball gowns, Venetian masks, suits, and tuxes are what to wear to this high class night of masks and murder. Get ready for a glamorous evening of mystery, intrigue and, murder.


text:
Call Flo
The Call Flo Radio Show was recognized as 'Best Morning Show' in the small market division by the Virginia Association of Broadcasters in 2012! Congratulations!
You can now listen to podcasts of the Call Flo Radio Show by clicking here or find us on iTunes. Just search Call Flo podcast !
Tune in weekdays beginning at 8:05 AM to WFLO AM and FM for the Call Flo Radio Show! Your hosts Francis Wood, along with Chris Wood, and Christopher Brochon, will bring you the show! Whether its some good news, birthdays and anniversaries, the word of the day, or laughs about sardines, join us on CALL FLO. We would love to hear from you during the show! The contact numbers for The Call Flo Radio Show are 434-392-8881 (local) or 1-800-825-5356 (long distance). Monthly, host Francis Wood will speak with 5th District Congressman Robert Hurt (R). Join Francis and the Congressman on the first Tuesday of the month to hear about what's going on in Washington D.C. and how it affects you!
Upcoming Interviews with Christopher Brochon:
Chris Brochon's Word of the Day If you come across or know some great words, send them to me at email@example.com.
10/6/2015: wabbit- exhausted; perhaps because you're slightly unwell
10/5/2015: mimsy- rather prim or over-restrained
10/2/2015: patulous- spreading; of the branches of a tree
10/1/2015: aa- a kind of basaltic volcanic lava that forms jagged masses with a rough texture
9/30/2015: velleity- an inclination not strong enough to lead to action
9/29/2015: tiffin- a light meal, usually lunch
9/28/2015: ogdoad- a group or set of eight
9/25/2015: deipnosophist- a master of the dining experience
9/24/2015: chiliad- a thousand things or a thousand years
9/23/2015: noctambulist- sleepwalker
9/22/2015: degust- to taste food or drink carefully so as to fully appreciate it
9/21/2015: peterman- a safecracker
9/18/2015: stercoraceous- consisting of or resembling feces
9/17/2015: operose- involving much industry or effort
9/16/2015: natation- swimming
9/15/2015: bruxism- the involuntary or habitual grinding of the teeth, typically during sleep
9/14/2015: erubescent- blushing or reddening
9/11/2015: borborygmus-the rumbling and gurgling sound caused by the movement of gas in the intestines
9/10/2015: argute- shrewd
9/9/2015: adscititious- supplemental, not integral
9/8/2015: zoanthropy- delusion of a person who believes himself changed into an animal
9/7/2015: ulotrichous- having woolly or crispy hair
9/4/2015: kakorrhaphiophobia- the fear of failure
9/3/2015: jentacular- pertaining to breakfast
9/2/2015: macrosmatic- denoting an abnormally keen olfactory sense
9/1/2015: impignorate- to pawn or mortgage something
8/31/2015: agastopia- admiration of a particular part of someone's body
8/28/2015: pauciloquent- that which uses few words in speech or conversation
8/27/2015: nudiustertian- of the day before yesterday
8/26/2015: quire- 25 sheets of paper; 1/20th of a ream
8/25/2015: erinaceous- of, pertaining to, or resembling a hedgehog
8/24/2015: bibble- (1) to eat or drink noisily (2) to imbibe often
8/21/2015: maeterlinckian- poetically symbolic; resembling the writing of Maurice Maeterlinck
8/20/2015: welkin- the sky, the upper air, the heavens, or the celestial sphere
8/19/2015: gry- the smallest unit in Locke's proposed decimal system of linear measurement, being the tenth of a line, the hundredth of an inch, and the thousandth of a philosophical foot. Basically, a trifle.
8/18/2015: pourparler- a discussion preliminary to negotiations
8/17/2015: propinquity- the state of being close to someone or something
8/14/2015: lutherie- the making of wooden stringed musical instruments
8/13/2015: chantelaine- the mistress of a castle or fashionable household
8/12/2015: runcation- the act of weeding
8/11/2015: circumlocution- the use of many words where fewer would do, in a deliberate attempt to be evasive or vague
8/10/2015: askance- with an attitude or look of suspicion
8/7/2015: disputatious- fond of having heated arguments
8/6/2015: timorous- showing nervousness, fear, or a lack of confidence
8/5/2015: codswallop- nonsense
8/4/2015: odsbodikins- by god's body
8/3/2015: hootenanny- an informal gathering of folk music and dancing
7/31/2015: absquatulate- leave abruptly
7/30/2015: cantankerous-bad-tempered and uncooperative
7/29/2015: mollycoddle- (v) treat someone very indulgently; (n) an effeminate man or boy
7/28/2015: syncope- the omission of letters or sounds from with in a word or phrase
7/27/2015: contumely- insulting language or treatment
7/22/2015: micromort- unit of risk measuring a one in a million probability of death
7/21/2015: hoosegow- prison
7/20/2015: ubiety- a state of existing and being localized in space
7/17/2015: opprobrious- disgraceful or shameful
7/16/2015: crudivore- an eater of raw food
7/15/2015: maunder- talk in a rambling manner or act in an idle manner
7/14/2015: flummox- perplex greatly
7/13/2015: blunderbuss- (1) short barreled large bored gun; (2) a person regarded as lacking in subtlety and precision
7/10/2015: lethologica- the inability to remember the correct word or phrase
7/9/2015: cavil- (v) to make petty objections (n) an objection of this kind
7/8/2015: inveigle- persuade by means of flattery or deception
7/7/2015: cadre- a small group of people specially trained for a particular purpose or profession
7/6/2015: debacle- a sudden failure
7/3/2015: consanguinity- kinship
7/2/2015: eldritch- weird and sinister
7/1/2015: erudition- the showing of great knowledge or learning
6/30/2015: jocosity- playfulness
6/29/2015: pablum- bland and insipid fare, entertainment, etc.
6/25/2015: spelunking- exploration of caves
6/24/2015: brouhaha- noisy overexcited critical response
6/23/2015: sanguine- cheerfully optimistic
6/22/2015: convoluted- extremely complex and difficult to follow
6/19/2015: enumerated- mentioned one by one
6/18/2015: quagmire- boggy area of land, or a hazardous situation
6/17/2015: divisive- tending to cause hostility between people
6/16/2015: forestall- prevent or obstruct
6/15/2015: narthex- an antechamber or porch in a church
6/12/2015: prognostication- the action of foretelling future events
6/11/2015: pellucid- translucently clear
6/10/2015: pensive- engaged in deep or serious thought
6/9/2015: kummerspeck- weight gained from emotional overeating
6/8/2015: nebby- overly inquiring, nosey
6/5/2015: pusillanimous- timid, lacking courage
6/4/2015: blandish- coax with words of flattery
6/3/2015: defenestration- the act of throwing someone out of a window
6/2/2015: deride-express contempt for
6/1/2015: gainsay- deny or contradict
5/29/2015: pogonotrophy- the act of growing and grooming facial hair
5/28/2015: detritus- waste or debris
5/27/2015: volitant- having the the power of flight
5/26/2015: quidnunc- a gossip or busybody
5/25/2015: legerity- physical or mental quickness
5/22/2015: tatterdemalion-ragged or unkempt
5/21/2015: frabjous- wonderful, elegant, superb
5/20/2015: cynosure-person or thing that attracts attention or admiration because of it's brilliance
5/19/2015: logy- sluggish
5/18/2015: ebullition- bubbling or boiling
5/15/2015: pulchritudinous- beautiful
5/14/2015: subterfuge- deceit in order to achieve one's goal
5/13/2015: intransigence-unwilling to change one's views
5/12/2015: eponymous-giving ones name to something
5/11/2015: gauche- lacking grace, unsophisticated
5/8/2015: wallydrag-a feeble or worthless person
5/7/2015: venality-motivated by bribery
5/6/2015: torpor- lethargy
5/5/2015: flagellant- one who subjects themselves or others to flogging
5/4/2015: complaisant-obliging or agreeable
5/1/2015: confabulation- an engagement in conversation
4/30/2015: culpable- deserving of blame
4/29/2015: escritoire- small writing desk with compartments
4/28/2015: coprolite- fossilized feces
4/27/2015: dilatory- slow to act
4/17/2015: funambulist- tightrope walker
4/16/2015: gentrify- to renovate and improve to middle-class taste
4/15/2015: globular-spherical
4/14/2015: forsooth- indeed, in truth
4/13/2015: brume-mist or fog
4/10/2015: opprobrious- language expressing shame or disgrace
4/9/2015: esculent- fit to be eaten
4/8/2015: poltroon- utter coward
4/7/2015: comportment- behavior
4/6/2015: panoply- a wide ranging and impressive array or display
4/3/2015: primogeniture- the state of being the first born child
4/2/2015: permutate- change the order of
4/1/2015: empyrean- deriving from heaven
3/31/2015: cantillate- to chant or intone
3/30/2015: encomium-writing that praises highly
3/27/2015: circumambient- surrounding
3/26/2015: manumit- release from slavery, set free
3/25/2015: panegyric- a public speech or published text in praise of someone or something
3/24/2015: anathema-something or someone that one vehemently dislikes
3/23/2015: postilion- person who rides the left-hand horse of a team when there is no coachman
3/20/2015: valetudinarian- one who is unduly anxious about their health
3/19/2015: exordium-the beginning or introduction esp. of a discourse or treatise
3/18/2015: murmuration- the act of murmuring
3/17/2015: galore- in abundance
3/16/2015: gird- encircle, secure, or surround
3/13/2015: butyraceous- in the nature of, or resembling butter
3/12/2015: aver- to assert to be the case
3/11/2015: sastruga-ridge of snow formed on a field by the action of wind
3/10/2015: predicate- something that is affirmed or denied concerning an argument
3/9/2015: wimple- a cloth headdress covering the head, neck, and sides of face
3/6/2015: quintessence- the most perfect example of quality or class
3/5/2015: ignoble- not honorable in character or purpose
3/4/2015: purloin- steal
3/3/2015: mien- a person's manner or look
3/2/2015: transmogrification-transform in a magical manner
2/27/2015: crepuscular- appearing at twilight
2/26/2015: recondite- little known
2/25/2015:persiflage- light and slightly contemptuous mockery or banter
2/24/2015: prescient-having knowledge of events before they take place
2/23/2015: inchoate- rudimentary
2/20/2015: perturbation- a deviation of a system
2/19/2015: aspersion- an attack on the integrity of someone
2/18/2015: testudinal- of, like or relating to a tortoise
2/17/2015: pecuniary- of or relating to money
2/14/2015: pigsney- a darling
2/13/2015: dephlogisticated- a substance supposed to exist in all combustible bodies, and released in combustion
2/12/uxorious-having or showing excessive or submissive fondness for one's wife
2/11/2015: tenet-a principle or belief
2/10/2015: coalesce- come together and form one mass or whole
2/9/2015: eponym- a person after whom a discovery, invention, or place is named
2/6/2015: supralapsarian- a person who believes that God decreed the election or non-election of individuals to salvation from the beginning
2/5/2015: emolument- a salary
2/4/2015: isostasy- the equilibrium that exists between parts of the earth's crust
2/3/2015: enmity- the feeling of being actively opposed to someone or something
2/2/2015: prevaricate- to speak or act in an evasive way
1/30/2015: paleoethnobotany- the study of the remains of plants cultivated by man in ancient times
1/29/2015: echelon- a level in an organization, profession or society
1/28/2015: scantling- the size to which a piece of wood or stone is measured and cut
1/27/2015: priggish-with a self-righteous, superior tone or attitude
1/26/2015: oblate- flatted at the poles; often the object is spheroid
1/23/2015: prognathous- having a projecting lower jaw or chin
1/22/2015: caprice- a sudden and unaccountable change of behavior
1/21/2015: plebiscite- direct vote of all members
1/20/2015: piebald-multicolored, black and white, or brown and white
1/19/2015: neoteric- modern, recent
1/16/2015: diaphragmatic- involving or resembling the diaphragm
1/15/2015: parlous- bad, dreadful, risky
1/14/2015: larrikin- disorderly or rowdy
1/13/2015: evanesce- vanish or fade away
1/12/2015: dowie- dull or melancholy
1/9/2015: monocotyledenous- any flowering plant having a single seed leaf with parallel veins, like grasses and orchids
1/8/2015: cogitation- the faculty of thinking
1/7/2015: caesura- an interruption or break
1/6/2015: sesquipedalian-polysyllabic
1/5/2015: belletrist-essay written and read for aesthetic effect


text:
Talking Points1 year ago News 5 comments
Today we have a video interview with mapper Ts4EVER concerning some of the new features with the upcoming map Gold Beach.
Forgotten Hope 2 is an award-winning World War II modification for Battlefield 2TM and is based on the original Forgotten Hope, a modification for Battlefield 1942TM, one of the most popular multiplayer games ever. Battlefield 1942TM featured land, sea and air combat in a way never before seen. It was the goal of the development team to maximize the game experience by adding both a realistic and enjoyable gameplay to FH and now to FH2.
Today we have a video interview with mapper Ts4EVER concerning some of the new features with the upcoming map Gold Beach.
A small update bringing news of a new tournament campaign and a render of one of our new Russian buildings.
Todat we show a render of the BMW R75 motorbike and sidecar.
Today we show some screenshots from the upcoming map Gold Beach.
Today we show off the render of our Polikarpov Po-2 biplane, the most produced bi-plane of all time.
Today we show off the fearsome Soviet multiple rocket launcher BM-13, better known as the Katyusha.
Today we show off the Finnish Suomi submachinegun.
Today we show off a render of the Finnish light machinegun: the Lahti-Saloranta M/26.
Today we present a render of one of the rifles used be the Finnish during the Continuation War and after.
Today we show off some of the Finnish and Soviet infantry equipment that you will be able to use on the Eastern Front.
This week we show off the SU-76M and its predecessor, the SU-76.
Our first update of 2013 brings you a render of the T-70 light tank.
A render of the Ferdinand, and the first screenshots of the Eastern Front; including the first sighting of the Finnish faction.
It has been five whole years since the first release of Forgotten Hope 2! A lot has changed since version 2.0.
Today we bring you a render of the Marder III Ausf. M.
Today we show a render of the Soviet light cavalry tank the BT-7 model 1937
A render of the M1910 Maxim watercooled machinegun, and news on a server patch.
This Forgotten Hope 2 news update contains Walther's prototype for the Gewehr 41.
Today we show off a render of the famous Mosin-Nagant rifle.
Some news about the most common tank of the Second World War.
A quick update on future plans for Forgotten Hope 2 post 2.45
The final part in our 2.45 release saga. The password and download links are contained within.
The third and penultimate part on the road to the release.
Still on the road to the release, we take a quick detour to show you some M3 Halftrack variants.
As you can no doubt guess from the title, today we are pleased to announce that Forgotten Hope 2 version 2.45 will be released later this week on Friday...
This week we have a render of some long requested playermodels. The 101st Airborne Division has finally dropped onto the battlefield!
This week we would like to show off a couple of screenshots of a vehicle that can get you swiftly across the Tunisian desert in relative safety. It is...
The Forgotten Hope 2 team is looking for talented modders with a passion for World War II and commitment to work hard. We need new fresh talent for our...
It has been a few weeks since our last update, and to make up for that, we have an update that is jam packed full of new content.
Today we are very excited to reveal something that has been sitting idle in our "vault" for quite some time now. It is the Curtiss-Wright P-40E Kittyhawk...
No news were found matching the criteria specified. We suggest you try the news list with no filter applied, to browse all available.Join now to share your own content, and encourage our community to get involved and engaged.


text:
6 Brilliant Portrayals of Editors on Film
Behind every good story is a good editor. Here are six examples of actors and actresses who brilliantly captured the essence of editorial excellence.
Behind every good story is a good editor. Here are six examples of actors and actresses who brilliantly captured the essence of editorial excellence.
Just when it was beginning to seem like director Niels Arden Oplev had turned into a missing person case worthy of Lisbeth Salander, this captivating trailer for "Dead Man Down" surfaced.
The involvement of these producers means great things for the future of this adaptation of the bestselling erotic novel.
As Swedish author Stieg Larsson's Millennium Trilogy blew up seemingly overnight, there was something bittersweet about discovering this "new" author: His catalog of work was finite. The late Larsson wrote[...]
Apparently some Amazon customers have panicked upon the arrival of their "Girl With the Dragon Tattoo" DVDs, mistaking the clever home-made-looking DVD art for an outright bootleg copy
As much fun as it was to read along while Twitter users live-blogged, there were moments that were actually worth watching, especially with regard to adapted works.
Are our strong female characters living up to their source material? According to today's links, the outlook is grim.
Is it Katherine Heigl's latest role, Lisbeth-mania, or our New Year's resolutions that have us obsessing over bad-ass females in the world of adaptations?
As the year 2011 winds down and we begin to look ahead to awards season, let's take a moment to look back at the year in adaptations.
The sixty-ninth Golden Globe nominations were announced this morning, and adaptations have made quite the showing on a substantial portion of the list.


text:
Thursday, January 3, 2008
© Copyright 2015 Clayton News Daily
Hildria Dyian FannHildria Dyian Fann, the only daughter of the late Lois and Hildridge Fowler, beloved mother of four, grandmother and great-grandmother of many and friend to all, passed away Dec. 30, 2007 in her daughter's home in Locust Grove, after battling liver cancer. For six decades she traveled and lived across the country enjoying different careers. Her most rewarding was working with the elderly for 11 years in Delray Beach, Fla. Throughout her life, Dyian took great pride in helping others. She will be most remembered for her generosity, kindness and sense of humor. She loved her family deeply and will be missed terribly. Dyian is survived by her children, Michelle Smith, Kimberly Boruty, Dionne Garcia and Sean Garcia; son and daughters-in-law, Kimberly Garcia, Traci Romero and Steve Pack; sister, Sheila Jenkins; grandchildren, Bryan Pack, Jennifer McGuirk, Nicole, Sean M., Brandon and Ramone Garcia, Blake Baron, Marisa Dalton, Amanda Jones and Austin Faulkener; five great-grandchildren; two great-aunts, a great-uncle and dozens of cousins and dear friends. A memorial service will be held on Saturday, Jan. 5, at 2 p.m., at Christ Covenant Church, located at 109 Hibernia Ave., Decatur, Ga., 30030. (404) 373-2933. Flowers may be delivered to the church on Friday, Jan. 4, from 11 a.m.-5 p.m., and Saturday before 1 p.m. Coleman Johnson Mr. Coleman Johnson, 92, of McDonough, passed away Sunday, Dec. 30, 2007, at Westbury Nursing Home. Coleman was born to the late Charles Johnson and Indiana Combs. He was a member of Shiloh Baptist Church in McDonough. He is survived by his devoted children, Edward Johnson, Gwendolyn Head, and Cynthia Penn; grandchildren, LaWanda Johnson, Joyce Head, Chauncey Johnson, Latoya Head, and Michael Head; seven great-grandchildren, two great-great-grandchildren, two sisters; one aunt, and a host of nieces, nephews, and cousins. Funeral services will be held TODAY (Jan. 3), at 2 p.m., at Shiloh Baptist Church, with the Rev. E. W. Lee officiating. Burial will be at McDonough City Cemetery. Arrangements entrusted to Speer & Speer Funeral Directors, (770) 957-3019. Cindy Hutson Ms. Cindy Hutson, of Jonesboro, formerly of Bethesda, Md., passed away Dec. 31, 2007. She is survived by her son, Dennis Sikes; daughter, Erica Hutson; mother, Bettie Houston; brother, Jimmy Houston; sisters, Linda Houston, Carolyn Meier, Jami Woodall; grandchildren, Emilee Sikes and Owen Sikes; and many nieces and nephews. Funeral services will be held at 11 a.m., Friday, Jan. 4, in the Jonesboro Chapel of Pope Dickson & Son. Interment will follow at Jonesboro City Cemetery. Family will receive friends at the funeral home from 5-8 p.m. TODAY (Thursday, Jan. 3.) Pope Dickson & Son, Jonesboro Chapel, (770) 961-2700.
More like this story
- Hilda Parker ( January 5, 2004 )
- Obituaries - Jan. 1, 2009 ( January 1, 2009 )
- Obituaries - March 18, 2008 ( March 18, 2008 )
- Obituaries ( December 29, 2003 )
- Obituaries ( December 30, 2003 )


text:
£1,500,000 Guide Price
Guide Price £1,500,000
4 bedroom detached house for sale Bay View Drive, Plaidy, East CornwallAn immaculately maintained detached house in very private waterside location yet still close to local amenities with 4.5 acres adjoining the foreshore. More details ›
Added on 12/07/2015 by Strutt & Parker, Exeter. Call: 01392 799092 Local call rate
4 bedroom detached house for sale The Crescent, Hannafore, West Looe, CornwallSUPERB DETACHED COASTAL RESIDENCE PRESENTER LED PROPERTY VIDEO! A beautiful detached coastal residence which enjoys lovely views onto Looe Bay and offers stylish and well presented accommodation that is currently utilised as an up market established holiday let providing a generous (contd...) More details ›
£559,950 Guide Price
Guide Price £559,950
4 bedroom detached house for sale Kellow, Looe, CornwallThe Express Estate Agency is proud to offer this REALISTICALLY PRICED opportunity – all interest and OFFERS are INVITED. Detached House Entrance Hall With Coat Cupboard Hallway With Stair Case 3 Reception Rooms One Of Which Including Cornish Stone ... More details ›
4 bedroom detached house for sale HANNAFORE LANE, Hannafore, West Looe, PL13A FANTASTIC OPPORTUNITY TO PURCHASE A SUPERB DETACHED 3/4 BEDROOMED HOUSE WITH UNINTERRUPTED PANORAMIC VIEWS OVER LOOE HARBOUR, BEACH AND COASTLINE TO RAME HEAD. Pengarth offers spacious living accommodation that has recently been updated and includes Upvc double glazing, gas central heating. More details ›
Reduced on 24/10/2014 by Popes Estate Agents, East Looe. Call: 01503 806001 Local call rate
4 bedroom detached house for sale Barbican Hill, Looe, Cornwall, PL13 4 BEDROOMS (ALL EN-SUITE) LOUNGE DINING ROOM CLOAKROOM KITCHEN/BREAKFAST ROOM UTILITY ROOM STUDY/BEDROOM 5 DOUBLE GARAGE GARDEN SECURITY GATES VIEWS GAS CENTRAL HEATING DOUBLE GLAZING AN OPPORTUNITY TO PURCHASE A SPACIOUS FOUR BEDROOMED (ALL EN-SUITE) DETACHED PROPERTY B More details ›
Added on 18/08/2015 by Popes Estate Agents, East Looe. Call: 01503 806001 Local call rate
4 bedroom cottage for sale Fore Street, West Looe, Cornwall, PL13A UNIQUE OPPORTUNITY TO PURCHASE A SPACIOUS GRADE II LISTED, 4 DOUBLE BEDROOM COTTAGE IN THE HEART OF WEST LOOE. PLUS GARAGE AND LOFT WITH PLANNING PERMISSION TO CONVERT. The property has been carefully modernised without taking away any of the charm from the Cottage. More details ›
Added on 14/07/2015 by Popes Estate Agents, East Looe. Call: 01503 806001 Local call rate
£420,000 Offers in Region of
Offers in Region of £420,000
4 bedroom detached house for sale St. Martin, Looe, CornwallFORMER B&B, LARGE PLOT, TOWN OUTSKIRTS An opportunity to purchase a substantial detached property offering spacious and versatile accommodation that lends itself ideally for use as a Bed and Breakfast establishment, however would also make a comfortable and generous family home. More details ›
4 bedroom detached house for sale Meadway, East Looe, CornwallDETACHED HOUSE IN SOUGHT AFTER COASTAL SETTING A detached house in a sought after coastal location enjoying extensive sea & coastline views that extend to Rame Head & over to St Georges Island. (contd...) More details ›
£395,000 Guide Price
Guide Price £395,000
4 bedroom detached house for sale Eastcliff, East Looe, Cornwall4 Bed Detached House with Garage A mature detached house nestled into a Cornish hillside from where it enjoys captivating coastal views that extend across the sea front to the harbour entrance and banjo pier, as well as out to Looe Bay towards Looe Island and the coast extending to (contd...) More details ›
4 bedroom detached house for sale Barbican Road, Looe, Cornwall, PL13**DETACHED 3/4 BEDROOM HOUSE IN A SOUGHT AFTER LOCATION AFFORDING SEA VIEWS** A viewing is highly recommended of this 3/4 bedroom detached house, situated on Barbican Road close to schools, shops and a range of amenities. The property affords stunning sea and coastal views to the Rame Head Penins... More details ›
Added on 15/04/2015 by Ocean & Country Estate & Letting Agents, Looe. Call: 01503 806005 Local call rate
Thank you.
Your information has been sent to 0 out of 9 agents who have property to sell in the area you specified.