text:
What changes were brought about to the HOA foreclosure sale landscape by the passage of SB 306 in Nevada?
SB 306 contained a number of important revisions to Nevada's super-priority lien statute that will provide...more
On Monday, the U.S. District Court for Nevada issued significant decisions in three cases, holding that a foreclosure on a Nevada HOA's super-priority lien could not extinguish a deed of trust securing a debt owned by a...more
Yesterday, the U.S. District Court for the District of Nevada issued an important ruling concerning the litigation over whether homeowners' association foreclosures under Nevada's super-priority lien statute (NRS 116.3116)...more
In the aftermath of the financial crisis, Fannie Mae and Freddie Mac aggressively demanded Wall Street and big bank aggregators ("aggregators") repurchase millions of defaulted and distressed loans, due to purported breaches...more
On May 20, 2015, both Fannie Mae and Freddie Mac issued updates (Fannie Mae Servicing Guide Announcement SVC-2015-08 and Freddie Mac Bulletin 2015-8, respectively) regarding the Eligibility Requirements for Seller/Servicers...more
On March 18, the FHFA Inspector General released a white paper detailing the challenges faced by the government-sponsored enterprises (GSEs) that could adversely affect their future profitability. According to the white...more
This is our fifth annual Golden Turkey Awards at CrunchedCredit. It just gets easier and easier. There are simply so many worthy contenders for an award this year. You know, we don't stop and take a moment often enough to...more
As November draws closer, the financial services industry is staking out a front row seat in tracking the outcomes of the 2014 midterm elections. The 114th Congress' legislative agenda in this area will be shaped in large...more
A September 29, 2014 Report of the Joint Federal Reserve/CFPB Office of the Inspector General (OIG) concluded that the CFPB's rulemaking process generally complies with the requirements of Section 1100G of the Dodd-Frank...more
Recently, the FHFA Office of the Inspector General (OIG) concluded that the FHFA can further mitigate the risks posed by Fannie Mae's and Freddie Mac's reliance on third-party mortgage loan sellers and servicers...more
On August 12, the FHFA requested comments on the structure of a proposed single security that would be issued and guaranteed by Fannie Mae or Freddie Mac (the GSEs). The implementation of the single security would be part of...more
On July 30, the U.S. District Court for the Southern District of New York ordered a bank to pay a nearly $1.3 billion civil penalty after a jury found the bank liable in October 2013 on one civil mortgage fraud charge arising...more
Early last week, recently-appointed director of the Federal Housing Finance Agency (FHFA) Melvin L. Watt, announced plans to keep GSEs Fannie Mae and Freddie Mac going strong. This new strategy is in stark contrast to the...more
On April 2, House Financial Services Committee Chairman Jeb Hensarling (R-TX), joined by Congressmen Scott Garrett (R-NJ) and Ed Royce (R-CA), urged FHFA Director Mel Watt to continue the FHFA's five-year-old policy of...more
Momentum in housing-finance reformation picked up speed last month as the House Financial Services Committee unveiled the proposed Housing Opportunities Move the Economy (HOME) Forward Act of 2014. The proposed HOME Forward...more
Anyone working in the commercial real estate mortgage industry in the past five or six years is eager for signs of a sustained recovery. Having just returned from the Mortgage Bankers Association Commercial Real Estate...more
On January 29, the DOJ filed a supplemental brief in support of its claim for civil penalties following a jury verdict it obtained last October in the first case alleging violations of FIRREA in connection with loans sold to...more
Adding to JPMorgan Chase's widely publicized recent legal woes, shareholder Bradley P. Miller filed a derivative suit against the bank and its directors in California federal court on January 23, 2014, as a result of the $20...more
From my work defending mortgage loan originators, including many homebuilder captives, against mortgage repurchase and indemnification claims, as well in my role as an editor of Bilzin Sumberg's Mortgage Crisis Watch, I have...more
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text:
Nyquil Cold Medicine - Can I take nyquil with zicam?
- Posted:
- 14 Mar 2013 by Mrs D
- Topics:
- nyquil, nyquil cold medicine, medicine
Answers (1)
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subset: commoncrawl


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- 5Promote
Art Print
Aung San Suu Kyiby Bharat KV
Collect your choice of gallery quality Giclée, or fine art prints custom trimmed by hand in a variety of sizes with a white border for framing.
To be kind is to respond with sensitivity and human warmth to the hopes and needs of others. Even the briefest touch of kindness can lighten a heavy heart. Kindness can change the lives of people. - Suu Kyi
My version of "Suu Kyi"
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|Loto Square Aluminium Dining Table
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text: This restaurant was so much better than I expected. The food was very good, the service was great and the Chiperones were the best I've had - Light, non greasy and great size portions and the chiperones themselves. My boyfriend had the steak and he said it was exceptional. The only issue was that... read more


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Fake Target Employee Hilariously Trolls Angry Customers
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Even the biggest country stars decorate their homes to celebrate Christmas. You would think they would hire someone to do the actual designing and decorating, and, I suppose some of them do... but not all of them.


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text:
Page 1
Autistic phenotypes and genetic testing: state-of-the-
art for the clinical geneticist
C Lintas, A M Persico
Laboratory of Molecular
Psychiatry & Neurogenetics,
University Campus Bio-Medico,
Rome, Italy and Department of
Experimental Neurosciences,
IRCCS. ''Fondazione Santa
Lucia'', Rome, Italy
Correspondence to:
Dr A M. Persico, Laboratory of
Molecular Psychiatry and
Neurogenetics, University
''Campus Bio-Medico'', Via
Alvaro del Portillo 21, I-00128
Rome, Italy; a.persico@
Received 6 June 2008
Revised 4 July 2008
Accepted 8 July 2008
This paper is freely available
online under the BMJ Journals
unlocked scheme, see http://
Autism spectrum disorders represent a group of
developmental disorders with strong genetic underpin-
nings. Several cytogenetic abnormalities or de novo
mutations able to cause autism have recently been
uncovered. In this study, the literature was reviewed to
highlight genotype–phenotype correlations between cau-
sal gene mutations or cytogenetic abnormalities and
behavioural or morphological phenotypes. Based on this
information, a set of practical guidelines is proposed to
help clinical geneticists pursue targeted genetic testing
for patients with autism whose clinical phenotype is
suggestive of a specific genetic or genomic aetiology.
Autism spectrum disorders (ASDs) represent a
heterogeneous group of neurodevelopmental dis-
orders characterised by social and communication
deficits, accompanied by repetititive and stereo-
typed behaviours, with onset before 3 years of
age.1 2From a diagnostic standpoint, ASDs coincide
with the Diagnostic and statistical manual of mental
disorders, 4th edition (DSM-IV) criteria for perva-
sive developmental disorders, including autistic
disorder, Asperger syndrome, childhood disintegra-
tive disorder, Rett syndrome and ''pervasive devel-
opmental disorder not otherwise specified'' (PDD-
NOS).1 2However, the concept of ASD is some-
what complementary to DSM-IV categorical diag-
noses, because it underlines that autistic-like traits
and behaviours represent a continual spectrum
rather than clinically defined diagnostic categories.3
The male:female sex ratio for autistic disorder is
4:1, implying an involvement of the X chromo-
some and/or imprinting mechanisms. Autism is
associated with seizures and mental retardation
(MR) in up to 30% and 80% of cases, respec-
tively.4 5
A prenatal origin of the disease is
supported by neuroanatomical and neuroimaging
studies, showing abnormalities stemming from
disturbed neurodevelopmental processes physio-
logically occurring during the first and second
trimester of pregnancy.6 7
Genetics strongly contributes to the pathogen-
esis underlying ASDs.8 9Rett syndrome, a mono-
mutations in the MeCP2 gene,10has been described
in detail previously.11In this review, we focus on
the remaining ASDs and especially on autistic
disorder, the neuropsychiatric disorder with the
highest monozygotic twin concordance rate (73–
95%), the highest heritability (.90%, as estimated
by twin studies) and a noticeable sibling recurrence
risk (5–6% for non-syndromic autism).8 9In addi-
tion the presence of mild autistic traits in first-
degree relatives of patients with autism points
towards a strong genetic component in ASD.3
Linkage and association studies have identified
numerous susceptibility genes, located on various
chromosomes, especially 2q, 7q, 15q and the X
chromosome.8 9The clinical heterogeneity of ASD
probably reflects the complexity of its genetic
underpinnings, involving multiple contributing
loci, genetic heterogeneity, epistasis and gene–
environment interactions.9Interestingly, epidemio-
logical studies reported an incidence of 2–5 in
10 000 newborn babies before 1985, whereas
studies performed after the year 2000 converge
upon rates of ASD as high as 20–60 in 10 000.12 13
This increase may stem from the use of broader
diagnostic criteria and increased attention by the
medical community,12 13but a real increase in
incidence of ASD due to environmental and
epigenetic factors acting upon a genetically vulner-
able background is also likely.9
Genetic screens represent a powerful tool when
dealing with monogenic mendelian disorders,
characterised by direct genotype–phenotype corre-
lations. In the case of complex disorders, such as
ASD, widespread genetic testing would not only be
expensive and time-consuming, but also generally
inappropriate due to the aetiological complexity
described above.9Nonetheless, there are at least
two instances where genetic testing can be
successfully used in complex disorder: to evaluate
the degree of genetic susceptibility to a certain
disease and to identify rare monogenic or cytoge-
netic forms of the disease. The appropriate use of
genetic testing in these two instances is good
clinical practice for the following reasons: (1) the
identification of susceptibility variants can allow
the implementation of prevention programmes, as
exemplified by familial breast and ovarian cancers
involving BRCA1 and BRCA2 mutations,14
familial colon cancer;15(2) the identification of
the exact genetic cause of an otherwise un-
explained disease, especially when it affects chil-
dren, can significantly reduce the levels of guilt and
anxiety in parents and improve their compliance
with medical interventions and to rehabilitation
During the past few years, genetic research in
ASDs has begun achieving some important suc-
cesses, including the identification of several
vulnerabilityloci and
abnormalities or single-base mutations able to
cause autism (see below). In order to transfer this
recently acquired knowledge into clinical practice,
it is critical to define a set of phenotypic inclusion
criteria that must be met by affected probands to
justify their enrolment in a specific genetic testing
programme. Accordingly, these genetic screening
ofa few cytogenetic
Page 2
programmes must be designed to use clearly targeted, feasible
and cost-effective strategies. We reviewed the relevant literature
to look for specific correlations between ASD-causing gene
mutations or cytogenetic abnormalities and clinical ASD
phenotypes (mainly behavioural and/or morphological ASD
phenotypes). We hope this information will be useful to guide
clinical geneticists in establishing and implementing effective
genetic screening programmes for those patients with ASD
whose phenotype is suggestive of a specific genetic or genomic
Syndromic autism (ASD associated with a known cause)
represents approximately 10% of all ASD cases and is often
associated with malformations and/or dysmorphic features.8 16
Unlike ''idiopathic'' or ''primary'' ASD, syndromic autism
shows an equal male:female sex ratio.17Syndromic autism can
be associated with well-known genetic or genomic disorders
(including fragile X syndrome, neurofibromatosis, tuberous
sclerosis, untreated phenylketonuria, and Angelman, Cornelia
de Lange and Down syndromes), with de novo chromosomal
rearrangements detectable by karyotyping (duplication of the
maternal 15q11-13 region, deletions of chromosome 2q37, 7q31,
22q11 and microdeletions of chromosome 22q11.2) and with
rare environmental events (prenatal central nervous system
infection by rubella or cytomegalovirus, prenatal exposure to
valproic acid or thalidomide).8 16
The recent advent of array-based high-resolution genomic
analysis has dramatically increased the power to detect small de
novo genomic deletions and duplications, down to a few
kilobases in size, well below the threshold of detection by
standard chromosomal banding and karyotyping techniques. At
least four independent genome-wide studies have identified de
novo microdeletions, microduplications or copy number var-
iants (CNVs) associated with autism using array-comparative
genome hybridisation (CGH) techniques using either bacterial
artificial chromosome (BAC) or single-nucleotide polymorphism
arrays.18–21Jacquemont et al18found that 8 of 29 (27.5%) patients
with autism carrying microdeletions or microduplications of
1.4–16.0 Mb in size, including six de novo chromosomal
rearrangements presented with dysmorphic facial features.
Sebat et al19found de novo CNVs in 10% of trios with one
affected child (12 of 118) and in 1% of normal trios (2 of 196).
Although the clinical characteristics of de novo CNV carriers
were not described in detail, they were interestingly not found
to be at increased risk of MR and some were apparently
diagnosed with Asperger syndrome, suggesting that CNVs may
also be associated with milder forms of autism, perhaps not
accompanied by dysmorphic features. Marshall et al20assessed
427 unrelated patients with ASD and 500 controls, finding 27
(6.3%) cases carrying de novo CNVs, which may be especially
present in simplex (4/56=7.1%) rather than in multiplex (1/
49=2.0%) families. Many, but not all patients, display
dysmorphicfeatures and/or
Christian et al21reported the presence of 7 de novo and 44
inherited CNVs in 397 patients with ASD. The clinical features
were not discussed in detail, but no evidence of signs or
symptoms shared by patients carrying de novo chromosomal
microdeletions or microduplications was reported. Using array-
based technologies, others have reported novel and possibly
recurrent microdeletion syndromes, affecting regions such as
16p11.2 and 2p15–16.1.22–24These studies have confirmed that
CNVs can be associated with a variety of clinical features,
including non-ASD behavioural disorders in siblings of patients
with autism. Therefore, the presence of malformations,
dysmorphic features and/or severe neurological symptoms
strongly points toward a possible cytogenetic origin for ASDs,
but their absence does not exclude it. The progressive transfer of
array-based approaches from the laboratory into clinical practice
will enhance our ability to detect an increasing number of
submicroscopic de novo chromosomal abnormalities.
neurological impairment.
Neuroligin 3/4 genes (NLGN3, NLGN4)
Neuroligins are cell-adhesion molecules localised postsynatpti-
callyinboth glutamatergic
NLGN4Y)and gamma-aminobutyric
synapses.9 25They interact with presynaptic b-neurexin, trigger-
ing the formation of functional presynaptic structures in
contacting axons. They also associate with postsynaptic
scaffolding proteins, such as SHANK3, also involved in ASD
(see below). The NLGN3 and NLGN4 genes, located at human
chromosome loci Xq13 and Xq22.33, respectively, have been
found to host rare mutations explaining ,1% of ASD cases
(table 1). Jamain et al26reported a frameshift (D396X in NLGN4)
and a missense (R451C in NLGN3) mutation in two unrelated
Swedish families, both mutations inherited from unaffected
mothers. In vivo studies using D396X or R451C mouse mutants
showed increased inhibitory synaptic transmission and impaired
social interaction,27paralleled by functional studies showing
Table 1
Neuroligin 3/4 genes and autistic spectrum disorders
ReferencePatients with ASD, n (sex)
mutations, n (%) Mutations/deletionsClinical phenotype
Jamain et al26
Blasi et al37
Vincent et al34
Laumonnier et al31
Ylisaukko-oja et al36
Yan et al33
Gauthier et al35
Wermter et al38
Lawson-Yuen et al32
124 (all M)
1 family with 13 affected males
1 family (1 affected male)
2/158 (1.26)
3/148 (2)
7/861 (0.8)
Del NLGN4, exons 4,5,61
Autism or Asperger syndrome
Mental retardation, autism, PDD-NOS
Mild to severe autism, PDD-NOS
Autism with motor tics
ASD, autistic spectrum disorders; PDD-NOS, pervasive developmental disorder not otherwise specified.
*Mutations also found in heterozygous asymptomatic mothers and/or other unaffected family members.
{Counted as a single mutation, because these were consanguineous individuals from the same large pedigree.
{Mutation found to be heterozygous in a female patient and in her mother (affected by a learning disability).
1Mutation found to be heterozygous in the patient's mother (learning disorder, anxiety and depression) and his brother (Tourette syndrome).
Page 3
defective vesicle-trafficking and synapse-induction properties.28–
30Extensive genetic screens conducted by several groups have
confirmed the low frequency of neuroligin mutations among
patients with ASD (7/861; 0.8%; table 1). Laumonnier et al31
found a frameshift mutation (D429X in NLGN4) in 13 affected
male members of a single pedigree (counted as one instance in
table 1, because they are related individuals coming from a
single pedigree). Lawson-Yuen et al32identified a deletion of
exons 4–6 of NLGN4 in an boy with autism and in his brother
with Tourette syndrome; the mutation was inherited by the
mother who also had neuropsychiatric disorders. Yan et al33
reported four other NLGN4 missense mutations in patients
with ASD (G99S, K378R, V403M and R704C). However,
V403M and R704C were also found in unaffected siblings,
suggesting they could represent rare non-synonymous variants
rather than true mutations. None of 553 patients with ASD
assessed in five other studies were found to carry NLG3 or
NLG4 non-synonymous variants.34–38In contrast, novel splice
variants were identified in autistic individuals by Talebizadeh
et al.39
The clinical phenotype of human NLG mutation carriers is
very heterogeneous. In both pedigrees carrying the D396X and
R451C mutations, two affected brothers carrying the mutated
gene were diagnosed, one with Asperger syndrome (the ''speech-
preserved'' variant of autism) and the other with autistic
disorder. The extended pedigree carrying the D429X frameshift
mutation in NLGN4 encompasses 10 male carriers affected with
non-specific X-linked MR, two male carriers with autism and
one with PDD-NOS (the autism variant not satisfying all
diagnostic criteria). Individuals carrying microdeletions invol-
ving the NLGN4 may even satisfy diagnostic criteria for
neuropsychiatric disorders apparently unrelated to ASDs.32In
addition, the G99S and K378R mutations yield broad clinical
heterogeneity, ranging from language disability to severe
autism. Mutation carriers typically display no dysmorphic
features, but interestingly they can undergo regression at
disease onset, characterised by a loss of initially acquired social
and verbal milestones. NLG mutations thus clearly exemplify
how regression does not necessarily imply the existence of
environmental factors striking at the time when behavioural
abnormalities become apparent, but simply stems from damage
to neural networks becoming evident at the time when they
should come ''on-line'' in order to support the harmonious
growth and expansion of social cognition.
In summary, NLG mutation carriers display a variety of
syndromes, ranging from X-linked MR without autism, to
Asperger syndrome, autistic disorder of variable severity and
PDD-NOS. Disease onset may be insidious or abrupt and
regressive. These patients do not share any morphological or
dysmorphic feature apt to spur a specific diagnostic investiga-
tion. The low frequency of these mutations and the lack of
phenotypic traits suggesting the involvement of NLG3 and
NLG4 do not encourage the clinical implementation of wide-
spread genetic screens for these genes in patients with non-
syndromic ASD.
SH3 and multiple ankyrin repeat domains 3 gene (SHANK3)
The SHANK3 gene is located on the telomeric terminal of
chromosome 22q13.3 and encodes for a scaffolding protein
found in the postsynaptic density (PSD) complex of excitatory
synapses, where it binds directly to neuroligins. Two recent
studies have shown a possible correlation between mutations or
small cytogenetic rearrangements affecting SHANK3 and an
ASD phenotype mainly characterised by severe verbal and social
deficits (table 2).40 41Similar to neuroligin mutations, SHANK3
mutations, deletions or duplications are rare, occurring in only
1.1% of patients with ASD. However, the genotype–phenotype
correlation reported in both studies suggests that patients with
autism with severe language and social impairment might be
good candidates for SHANK3 mutation screening. Five of seven
cases reported to date carry deletions (142 kb to 4.36 Mb in
size), of the terminal 22q13 region encompassing SHANK3,
whereas the other two have a frameshift (E409X) and a
missense mutation (Q321R).40 41Furthermore, rare non-synon-
ymous variations present in the ASD group, but not in the
control sample, were also found in both studies.40 41However,
these variations were inherited from healthy parents and
sometimes were also present in unaffected siblings, suggesting
that they may confer vulnerability rather than play a dominant
role in ASD pathogenesis. Indeed two of the mutations (R12C
and R300C) were associated with severe language problems and
social interaction difficulties. In vitro overexpression of these
variants resulted in diminished colocalisation with the pre-
synaptic marker protein Bassoon, suggesting nonsynaptic
clustering of mutated SHANK3.40Incomplete penetrance of
these variants could explain their presence in other unaffected
family members. Alternatively, they may cause the disease by
acting synergistically with other susceptibility genes.
It is interesting that both studies reported an inherited 22q13
deletion involving SHANK3 (800 kb in Durand et al40and
3.2 Mb at 22q13 in Moessner et al41), stemming from a paternal
balanced translocation. In both studies, the probands with
autism had siblings with partial 22q13 trisomy affected by
disorders as different as Asperger syndrome with early language
development40and attention deficit hyperactivity disorder.41
These observations suggest that fine-tuning of SHANK3 gene
dosage may be crucial for the development of language and
social cognition in humans.
The neurexin 1 gene
Presynaptic neurexins induce postsynaptic differentiation in
contacting dendrites, by interacting with their postsynaptic
neuroligin partners.9 25The three neurexin genes (NRXN1,
NRXN2 and NRXN3, located at the human chromosome loci
2q32, 11q13 and 14q24.3-q31.1, respectively) have two inde-
pendent promoters, which determine two mRNA classes: long
mRNAs, encoding for a-neurexins and short mRNAs, encoding
for b-neurexins.42A mutational NRXN1b screening conducted
by Feng et al43on 264 patients with ASD identified two
heterozygous missense mutations (S14L and T40S) and a GG
insertion in position 26 of the corresponding protein (table 3).
The two missense mutations were present in 4/264 (1.5%)
patients with ASD and not in 729 controls, but they also
occurred in first-degree relatives (parents and/or unaffected
siblings), who displayed very heterogeneous phenotypes ranging
from hyperactivity, depression and/or learning problems to
apparently normal behaviour. Similarly, one of two chromoso-
mal rearrangements affecting the NRXN1 gene were also shown
to be paternally inherited in one patient.44The same study also
reported two rare missense variants (L18Q and L748I) in 2 of 57
people with ASD.44People with autism carrying the S14L
mutations apparently have seizures and facial dysmorphisms.43
No clinical and family data were reported for patients carrying
the insertion. In another study, a de novo heterozygous 300 kb
deletion in the coding exons of the NRXN1 gene was found in
two affected sisters, who both received a diagnosis of autism.45
However, one girl was reported to be non-verbal, whereas the
other had mild language regression.45In a recent case–control
Page 4
study by Yan et al,46five rare patient-specific variants were
identified in 116 ASD individuals whereas only one additional
variant (G28A) was also found in controls. Unfortunately, no
clinical or family data are available for this study.
The presence of deletions or other mutations also in unaffected
siblings of patients with autism and even in controls,43 44 46
suggest that such mutations could confer vulnerability to ASD
rather than causing the disease. In addition, the small number of
studies performed to date on the putative link between neurexin
genes and autism suggest caution in addressing potential
genotype–phenotype correlations.
The methyl-CpG-binding protein 2 gene
Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional
repressor that binds to methylated CpG dinucleotides generally
located at gene promoters and recruits HDAC1 and other
proteins involved in chromatin repression.11De novo mutations
of the MECP2 gene located on chromosome Xq28 occur in 80%
of female patients with Rett syndrome, a pervasive develop-
mental disorder generally characterised by regression, autism,
microcephaly, stereotyped behaviours, epilepsy and breathing
problems, whereas in males, mutations are generally lethal.10 11
Some mutations can also result in asymptomatic phenotypes,
mild MR and verbal Rett variants.11The clinical phenotype
dependsuponthe type of
X-inactivation pattern, which is highly skewed in the presence
of mutations affecting X-linked genes, such as NLGN3 and
MECP2, but is not significantly skewed in ASD families
Several groups have screened the MECP2 gene for mutations
in patients with non-syndromic ASD (table 4).Of 11 studies, 2
have identified de novo MECP2 mutations in female patients
with ASD: a de novo splice variant in intron 2 (IVS2 +
2delTAAG), a frameshift mutation (1157del41) and a nonsense
mutation (R294X).48 49Interestingly, the phenotype associated
with this mutation includes MR but not epilepsy, microcephaly,
mutationand the specific
stereotypies or any of the symptoms characteristic of Rett
syndrome; regression was present in one patient, but not in the
other two.48 49Another study identified two de novo mutations
(R133C and R453X) in girls with ASD fulfilling the criteria for
the preserved speech variant of Rett syndrome.50The remaining
eight studies were either entirely negative or reported missense,
intronic or 39-untranslated region variants potentially of
functional interest; either these were reported to be inherited
from one of the parents or it was not specified whether they
were inherited or de novo.51–58Overall, MECP2 mutations are
rare in the autistic population, accounting for 0.8–1.3% of cases
in the female ASD population (ie, 3/378 or 5/397, respectively,
depending whether patients from the Zappella et al study50are
included (table 4) and not including subjects from the
Shibayama et al53study for which no male:female ratio is
provided). Importantly, female patients with ASD carrying
MECP2 mutations appear mentally retarded, but do not display
any clinical trait resembling Rett syndrome. Signs and
symptoms more typical of Rett syndrome may be of later
onset, requiring that female patients with ASD be clinically
monitored over time.59
The homeobox A1 gene
HOXA1 is a homeobox gene located at human chromosome
locus 7p15.3, essential to the development of head and neck
structures, including hindbrain, ear, and occipital and hyoid
bones.60 61Homozygous recessive stop-codon mutations of this
gene have been found in nine people belonging to four
consanguineous families from Saudi Arabia and one from
Turkey.62 63
Two differentmutations
84CRG mutation results in the introduction of a stop codon
in the Turkish person, and a 175–176insG causes a reading
frame shift and premature protein truncation in the Saudi
Arabian patients. The probands of these families showed a
similar phenotype characterised by horizontal gaze abnor-
malities, deafness, focal weakness, hypoventilation, vascular
Table 2
SHANK3 and autistic spectrum disorders
with ASD, n
De novo
mutations, n (%) Mutations/deletionsClinical phenotype
Durand et al40
Moessner et al41
3/227 (1.3)
4/400 (1)
142 kb del at 22q13, E409X, 800 kb del at 22q13*
277 kb del at 22q13, 3.2 Mb del at 22q13,* 4.36 Mb
del at 22q13, Q321R
Autism with severe language and social deficits
Autism with non-verbal communication and social deficits
Total627 7/627 (1.1)—
ASD, autistic spectrum disorders.
*Parents have a balanced translocation.
Table 3
Neurexin 1 and autistic spectrum disorders
Patients with
ASD, n
De novo
mutations, n (%) Mutations/deletionsClinical phenotype
Feng et al43
264 (219M+45F) 0/192 (0) S14L*, T40S,* 26insGG{
Autism with seizures and facial
Autism with mild to severe spoken
language deficits
The Autism Genome
Project Consortium45
Kim et al44
1962/196{ (0.5)300 kb del at 2p16
570/57 (0) ins(16;2)(q22.1;p16.1p16.3).* t(1;2)(q31.3;p16.3).1
R8P, L13F, G28A,* c1024 +1 GRA,{ T665I,{ E715K{
Yan et al46
0/116 (0)
1/633 (0.15)
ASD, autistic spectrum disorders.
*Mutations found also in other non-affected family members or in controls.
{No clinical and pedigree information available; not specified if occurring de novo.
{Counted as ''1'', because affected members were consanguineous relatives from the same pedigree.
1Rearrangement localised ,750 kb 59 to the NRXN1 locus.
Page 5
malformations of the internal carotid arteries and cardiac
outflow tract, MR and autism in some, but not all patients:
this clinical set of symptoms and malformations was named
Bosley–Salih–Alorainy syndrome (BSAS).63
The phosphatase and tensin homologue gene
PTEN is a tumour suppressor gene located on human chromo-
some 10q23, influencing G1 cell-cycle arrest and apoptosis. In
the central nervous system, PTEN inactivation results in
excessive dendritic and axonal growth with increased numbers
of synapses.64Germline mutations resulting in PTEN haploin-
sufficiency thus facilitate cell-cycle progression and oncogenesis,
leading to macrocephaly/macrosomy and to cancer develop-
ment, respectively.65Germline PTEN mutations have been
found in approximately 80% of individuals diagnosed with
Cowden syndrome, accompanied by enhanced risk for breast,
endometrial and thyroid malignancies.65People with other
related hamartomadisorders,
Ruvalcaba syndrome, Proteus and Proteus-like syndromes dis-
play germline PTEN mutations in 60%, 20% and 50% of cases,
respectively.65In addition, somatic PTEN mutations have been
found in a variety of human tumours.65Interestingly, genetic
syndromes due to PTEN germline haploinsufficiency, in addi-
tion to excessive, dysplastic or neoplastic growth, are often
characterised by autism or MR and progressive macrocephaly, as
initially reported by Goffin et al.66A study by Butler et al67
identified three de novo heterozygous PTEN germline muta-
tions in 18 (16.6%) people with macrocephaly and autism
(table 5). The three newly identified mutations all lead to
missense changes in evolutionarily conserved aminoacid resi-
dues. Others found PTEN mutations in different percentages of
macrocephalic patients with ASD68–70(in one case also display-
ing polydactyly of both feet).70
Cases of ASD with PTEN mutations are invariably char-
acterised by severe to extreme macrocephaly (ie, cranial
circumference .97th percentile or +2 SD, but PTEN mutation
carriers with ASD typically display >+3 SD). Macrocephaly has
been consistently found in approximately 20% of patients with
autism recruited in independent samples.71–75Head circumfer-
ence in these patients with ASD is typically normal at birth and
an overgrowth seemingly develops over the first few years of
life.76Interestingly, the majority of macrocephalic patients are
suchas Bannayan–Riley–
actually macrosomic, as head size is significantly correlated with
excessive height and weight in this subgroup of patients with
autism.77The incidence of PTEN de novo mutations in these
macrocephalic/macrosomic patients with ASD can be estimated
at 4.7% (6/126) (table 5). Importantly, these patients are at
increased risk of developing a variety of PTEN-related cancers
during adulthood.
Based on the information summarised above, we have defined a
set of practical guidelines that clinical geneticists should
consider, together with recently reviewed ethical issues,78when
providing genetic counselling to parents of autistic children.
If a couple has a non-syndromic autistic child, the
probability that a second child will also be autistic is
approximately 5–6%.
A karyotype and fragile-X testing must be requested for all
patients with ASD.
Clinicians should be aware that prenatal genetic testing
typically raises unrealistic expectations in parents of
children with autism because, with the exception of rare
gross chromosomal rearrangements, the genetic or genomic
anomalies responsible for ASD are not detectable using
current prenatal screening methods.
In the presence of dysmorphic features and evident
neurological symptoms, it is reasonable to suspect chromo-
somal rearrangements even if the karyotype appears normal.
Depending upon availability and cost, a BAC or oligo array-
based CGH analysis is strongly advised in these cases. As
these technologies will become progressively more available,
it will be important not to restrict them to patients
with dysmorphia, as microdeletions and microduplications
are also common among patients with idiopathic, non-
dysmorphic ASD.
Patients with NLG3 and NLG4 mutations do not share any
specific clinical features and the frequency of these muta-
tions is sufficiently low that widespread screening for
neuroligin mutations do not seem to be clinically justified.
For the same reasons and owing to the small number of
studies performed to date, widespread screening for the
neuroxin genes are also not advisable at present.
Table 4
MECP2 and autistic spectrum disorders
Patients with
ASD, n
De novo
mutations, n (%)
deletions Clinical phenotype
Lam et al48
Vourc'h et al51
Beyer et al52
Carney et al49
21 (all F)
69 (all F)
1/21 (4.8)
2/69 (2.9)
1157del41, R294X
Autism and MR. No regression, epilepsy or microcephaly
Autism, MR and history of regression. No stereotypies,
epilepsy or microcephaly
Preserved speech variant of Rett syndrome
Zappella et al50
Shibayama et al53
Lobo-Menendez et al54
Li et al55
Xi et al56
Harvey et al57
Coutinho et al58
19 (all F)
31 (all M)
2/19 (4.7)
0/24 (0)
0/31 (0)
0/172 (0)
c1638 GRC,* c 6809 TRC,* P376R{
1 39UTR variant*
12 39UTR variants.{ 2 intronic variants,{
— Total 397F, 741M{
5/397 females (1.3),
0/741 males
ASD, autistic spectrum disorders; MR, mental retardation; UTR, untranslated region.
*Mutations found also in other non-affected family members or in controls.
{Not specified if occurring de novo; no pedigree information available.
{The study by Shibayama et al53did not provide an M:F ratio and was excluded from the total.


text:
Narrow your search
You don't have to be a hipster to want a cell phone that dials like a rotary landline telephone, but it helps.
Watch a new generation of phone users try to figure out rotary phones, dial tones, and busy signals. This "Kids React" video from The Fine Brothers promises to make you feel ancient.
The Sphero BB-8 toy may not be powered by the Force, but Bill Detwiler cracks this rolling robot open to show you the tech inside.
Barbie always makes a fashion statement, but now that she has a hidden a knife, corkscrew, scissors, screwdriver and bottle opener she can solve any problem you throw at her.
The Uuni 2 is an affordable outdoor oven. Reaching temperatures as high as 840 degrees, the wood-pellet oven brings pizza convenience to a new level.
Technically Incorrect: A Massachusetts driver makes a wrong turn. What happens next, all filmed on his dashcam, has led to an investigation. And yes, it's now on YouTube.
Columbia University researchers discover a new source of alternative energy by harnessing the power of evaporation and soil bacteria spores.
The next generation of tech-savvy kids review the Apple Watch with mixed results in the latest "Kids React" video from The Fine Brothers.
Watch children try to figure out how to play a VHS tape in a videocassette recorder in this latest "Kids React" video from The Fine Brothers.
First and foremost, the Fostex PX-5HS speakers sound remarkably clear, and don't let their small stature fool you, the little speakers' bass is rich and full.


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This Tesco striped runner is made from a polypropylene pile with a non-slip latex back, making it suitable for use on many types of floor surface around the home. The mat is suitable for indoor use and is machine washable.
Catalogue Number: 211-1810
- L150xW57cm
- Polypropylene with latex backing
- Machine washable
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Sign up to get DCRB email updates such as the DCRB Newsletter to Participants, COLA information, and more. From the list provided, choose "DCRB News" under the DC Retirement Board section. Sign up now.
Current Legislation
Last updated on March 17, 2015
Listed below are current legislative items affecting the District of Columbia Retirement Board (DCRB). For more information on each piece of legislation, download the corresponding PDF from the list below.
- H.R. 606, "Don't Tax Our Fallen Public Safety Heroes Act": This proposed bill amends the Internal Revenue Code to clarify that state-based survivor benefits on behalf of a public safety officer who has died as the direct and proximate result of a personal injury sustained in the line of duty are exempt from federal tax. The bill passed in the House of Representatives on May 12, 2015 and in the Senate on May 14, 2015. The enrolled bill is now under consideration by the President.
- IRS Notice 2015-07, "Relief for Certain Participants in § 414(d) Governmental Plans": The Internal Revenue Service and Treasury Department announced in IRS Notice 2015-07 (Jan. 23, 2015) that they are updating the definition of a "governmental plan" to include charter school teacher participation. Many state teachers' retirement systems, including the District of Columbia Teachers' Retirement Plan, allow public charter school teachers to participate even though the charter school teachers work for a nongovernmental entity. Future federal proposed rules would allow public charter school teachers to participate in state or local retirement systems under certain circumstances without compromising the governmental plan status of those plans.


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Beyond the Assignment: Defining Photographs of Architecture and Design
Curated by Bilyana Dimitrova, The Julius Shulman Institute at Woodbury University exhibition features individual artists who are often hidden behind the projects that they document, including: Peter Aaron, Bilyana Dimitrova, Joe Fletcher, Timothy Hursley, Alan Karchmer, Jon Miller, Tim Street-Porter, Undine Pröhl, Lara Swimmer and Paul Warchol.
"Beyond the Assignment: Defining Photographs of Architecture and Design examines the work of ten of today's leading architectural photographers in the United States. By expertly documenting and artfully interpreting the built environment, these artists provide a critical contribution to the history of photography, mass media, and the architecture profession. Beyond the Assignment takes a long-overdue look at the way architectural photographers use visual storytelling, technical precision, and a unique visual sensibility to shape the way we see the built environment. In so doing, these photographers move "beyond the assignment" and help immortalize today's architecture and design." Click here to see more information.


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Our Blog.
Automatically restart struggling Heroku dynos using LogEntries
We have a Rails app hosted on Heroku which periodically develops a memory leak, pushing it well over Heroku's per-dyno memory quote and slowing everything down as it hits swap. The issue is intermittent, random, and only happens every few days but it's easy enough to deal with, just restart the dynos. However it has a Read More »
Getting accurate code coverage metrics from SimpleCov in a Rails project
We use SimpleCov to track code coverage of our tests in Rails projects. For coverage to be in any way useful as a metric it needs to be accurate. We noticed that files for which we had no tests were not being tracked and not included in the coverage. Therefore, our coverage metrics were artificially high and Read More »
Preventing page redirects to data:, in Safari
Safari has a built in XSS auditor that tries to prevent reflective XSS attacks – where the attacker submits content through a POST request and it is immediately displayed back in the response. To do this it looks for tags, including <script> and <iframe>, in the POST params. If it finds any, it looks Read More »
Limit the size of your Rails test and development logs
I just ran out of disk space and went looking for things to delete, I was amazed to find nearly 10Gb of test.log and development.log files kicking around. "Surely there must be a way to limit the size" I thought. There is! And it's easy. And you should definitely do this now. In your config/environments/test.rb Read More »
How to get More Bang for your Heroku Buck While Making Your Rails Site Super Snappy [Redux]
I first wrote about how to get the most bang for your Heroku buck a year ago. Since then a few things have changed and we've learnt even more about how to deliver great performance from our Heroku hosted sites. Some of the advice remains the same, but there are some important changes. There is Read More »
Using Pow with RVM 1.19's .ruby-version and .ruby-gemset files
With the upgrade to RVM 1.19 you are asked to convert your old .rvmrc file into .ruby-version and .ruby-gemset files. You are using '.rvmrc', it requires trusting, it is slower and it is not compatible with other ruby managers, you can switch to '.ruby-version' using 'rvm rvmrc to [.]ruby-version' or ignore this warnings with 'rvm Read More »
oAuth Twitter for PHP and WordPress developers: Version 2!
Yesterday, I released version 2.0 of our oAuth Twitter PHP class and WordPress plugin. It's a simple way of handling all of the oAuth requirements in Twitter's API v1.1 that become mandatory on 5th March 2013. For more information about the plugin itself, you can read my original post on the first release. Version 2.0 is Read More »
How to save the uploaded file name with carrierwave_direct and S3
So you've setup carrierwave_direct and you're happily uploading files to Amazon S3. In this example I've mounted CarrierWave on a field called csv_file, but that can be whatever is appropriate to your app. You've probably got two controller methods def upload @model = Model.new @model.save @uploader = @model.csv_file @uploader.success_action_callback = upload_successful_model_url(@model) end def upload_successful @model Read More »
How to show comments on a separate page in WordPress
Struggling to give WordPress comments their own page without messing up your URL structure? I know the feeling. Displaying a post's comments separately from the main content can be useful in many circumstances. Although less common nowadays, traditionally many blogs chose to feature comments in a pop-up window or lightbox. It can also be desirable Read More »
6 Ways to get More Bang for your Heroku Buck While Making Your Rails Site Super Snappy
We love Heroku. It makes deployment so easy and quick. However, it can start to get pricey when you add additional dynos at $35 each a month. With a small amount of work, you can get a lot more out of your Heroku hosting whilst drastically improving the performance of your site. You might need Read More »


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Oct 1- ConAgra Foods Inc said it will cut about 1,500 jobs and outsource technology and back office positions, joining other packaged food companies in announcing cost cuts, and the company also plans to move its headquarters to Chicago from Omaha. ConAgra rivals including Campbell Soup Co and General Mills have cut jobs and costs as consumers shift to fresher...» Read More
Hummus sales are booming, and Sabra is on a quest to convince Americans to eat even more. Is it the next peanut butter?
Despite the high revenue, the profit margins in the grocery business traditionally have been low, but that hasn't stopped retail giants Amazon and Wal-Mart from escalating the national food fight. What gives?
Smithfield Foods bought by China's largest meat producer, Shuanghui, is facing regulatory and political scrutiny, reports CNBC's Michelle Caruso-Cabrera.
The world's largest hog farming and pork processing company has agreed to be acquired by China's largest meat processor, reports CNBC's Michelle Caruso-Cabrera.
Parents might not recognize E. Robert Kinney by name, but they owe him a debt of gratitude for popularizing what might be the only kind of fish their kids will eat.
The food supply is under siege from a blitz of man-made hazards, from arsenic-laced chicken to dying bee colonies, and some favorites may someday vanish from the plate.
Tyson Foods reported a weaker-than-expected quarterly profit as shoppers and restaurants switched to cheaper chicken from beef, and the company cut its full-year sales forecast.
The classic Twinkie will hit store shelves nationally by late July, Hostess Brands told NBC News.
The maker of Chef Boyardee pastas and Hunt's ketchup reported a 57 percent fall in third-quarter profit, hurt by costs related to its acquisition of Ralcorp.
Beer lovers have plenty of options, but which label do consumers love the most? The madness is underway. Vote for your favorite.
The IPO of Pinnacle Foods priced at $20 a share, at the high end of the range. One trader said the stock could pop on its debut Thursday amid expectations of a "hefty dividend."
Sally Smith, President and CEO of Buffalo Wild Wings, explains why she decided not to advertise during the Super Bowl, when more than 8 million wings are served.
Hormel Foods apparently has a hankering for a peanut butter and bacon sandwich. The company known for Spam and other deli meats said Thursday it's buying Skippy.
A Texas-born quickie mart chain explodes across tropical Asia. The Global Post reports.
Hostess Brands, the maker of Twinkies, Wonder Bread and other household-name products - said it would seek this week to liquidate the company unless enough workers stopped striking by the end of the workday on Thursday.
CNBC's Robert Frank gives viewer a rare look inside a meat locker holding a million dollars worth of steaks.
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Qualcomm's CEO Paul Jacobs says the smart phone will become a focal point for wirelessly connecting medical devices, diagnostics and sensors, and providing near real-time information.
The aging of America is taking a toll on the health care system. By 2050, the cost of treating Alzheimer's patients will hit $1 trillion a year.


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video shot and edited by: George Forste
2011 idgf underground
band members:
Sammy Wulfeck - Bass & Vocals
Ric Hickey - Guitar & Vocals
Brian Kitzmiller - Drums
Cincinnati, Ohio's Sparrow Bellows plays straight-up Rock n Roll with unforced smart-ass exuberance in the spirit of early Cheap Trick and The Replacements. They are jeans and t-shirt simple with a wild streak of Art Rock complexity and Pop Rock ferocity. With their catchy tunes and tight vocal harmonies, Sparrow Bellows is a dynamic live act with a phenomenal guitarist. Ric Hickey is one of those rare guitarists who can convincingly shift from rhythm to lead and back again without tripping on the transitions, bringing to mind the likes of Jimmy Page and Angus Young. Hickey channels his love of Frank Zappa, Adrian Belew, The Beatles and The Stones into every clever phrase he wrings out of his old beat-up Telecaster Deluxe. The only thing keeping Sammy Wulfeck from wrecking his Rickenbacker with maniacal John Entwistle bass runs is his important role as co-frontman, his dusky vocals taking the lead on a good many of the band's infectious numbers. And as Sparrow Bellows' big man in the back, drummer Brian Kitzmiller anchors it all with thundering whimsy, providing a slippery backbeat and the perfect percussive atmosphere for the band's infinite variety of moods.
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Top 10 Greatest Electronic Artistsgoohan
The Top TenXW
Even a brainless monkey will no that daft punk are the true essence of electronica. There should be a statue of them in every city in the world!
With out a shout of a doubt, the best electronic duo ever! They made more memorable songs than ANY electronic artist ever! You cannot argue with "Da Funk, " "One More Time, " "Aerodynamic, " "Harder Better Fast Stronger, " "Robot Rock, " "Technologic, " & "Too Long, " because they are all the pioneer of the electronic genre!
Daft Punk are the creators of a genre, Thoma and Guy-Man alone brought us French House, and shaped the electronic music industry into what it is today. The Robots have worked alongside classic disco artists like Nile Rodgers, Georgio Moroder, and even more. While I don't disagree with Deadmau5 being on the list, these two belong on top. Joel said himself he was inspired by Daft Punk, and even the idea of a helmet came from them.
Daft punk is great, and deserves #1.V93 Comments
He revived the electronic genre scene and his talent shows in his original mixes and his remixes. He can be considered the "Kanye West" of the electronic scene with his oversized ego but a genius when it comes to his art.
I wouldn't EVER compare deadmau5 to that knob we call Kanye West. Deadmau5 is actually inspiring, and doesn't call himself what he isn't. - PositronWildhawk
Why is Deadmau5 no. 19!?! Has anyone hurd of em. He's amazing listen to strobe, aural pynapse, ghosts n' stuff then come back here and vote for him!
This guy is a music genius! In todays electronic music scenario he is truly turning the tides! Just check out the number of genres he's into! Being where he is demands a lot of respect! His music is well thougt of, not randomly aranged pumping beats! I like his progressive style and the fact that he iexperiments a lot, not making music just for seling he truly puts his creativit to test which is a mark of a future legend!
He called skrillex a dumbass on phone! Its on youtube! That said skrillex rocks 2!
Deadmau5 is the best! Plus he's Canadian like meV77 Comments
He truly is great. I feel that people only hate on him because he's gotten so popular all of the sudden, and a lot of stupid people think that he's the only artist that makes electronic music (although they think all electronic music is dubstep). Don't hate the artist, hate the ignorant mass of people that don't know anything about electronic music, and make skrillex look bad. (If you truly don't like skrillex because you don't like him music, and not because of his awful fan base, then I have nothing against you. Everyone is entitled to their own opinion. However, If you barley listen to any of his music, and you just don't like him because he's gotten more mainstream and has an awful fan base, then grow up. Judge someone's music on their actual music, and nothing else. )
Skrillex is one of the best DUBSTEP artists out their and yes I say Dubstep. Its sad how some to many of his fans don't even know that dubstep is a sub genre to electronic music. To the electronic music is dubstep. And this may make skrillex look bad. However on the other side if you just hate skrillex because he has too much fame then just call yourself a hipster (ha ha hipsters don't call themselves hipsters) Skrillex did a nice job on his new EP with my new Favorite song The Reason. You should check it out. However even if Skrillex is the best Dubstep producer you should check out other sub genres like House or Electronica.
Skrillex, outside of his Scary Monsters and Nice Sprites song, sucks. His music is annoying, employs so many disturbing vocals in it, and just ruins every one of his songs because of it. If you want to make a song great, put things people would actually want to hear! Those "chipmunk" voices are just awful. Please take them out, and your music will be GREAT!
The best in dubstep!V56 Comments
HAHAHA Owl City at number 2 before Aphex Twin HAHAHA
Aphex Twin changed the face of electronica forever because he's a real artists who creates to express himself. He said it, the most important thing in music is emotion. Would Owl City say that? No. He doesn't even believe that himself.
Aphex twin produces amazing beautiful and emotional music. I have no problem with daft punk but Owl city? Come on people. Deadmau5 is pretty good but he isn't among the ranks of Aphex twin. I think everybody who voted for owl city should go out and listen to aphex twin now to change their mind. This is great music.
My personal opinion is that Aphex Twin should be at Number 2, second only to Daft Punk. Anybody that has a passion for electronic music would agree I feel.
Aphex Twin revolutionized electronic music. Sure he hasn't sold as many records as Skrillex or Deadmau5 but he's a genius that injects a much needed heart and soul into the electronic scene.
The man is pretty much an electronic composer. He puts most of these other artists at the top to shame.V39 Comments
You don't even need to know the name of the song to know it's Zedd when you hear it! His style may not appear different and unique the first time you hear it, but as you listen to more of his music, you soon notice things that make his style unique.
He is great.
His different style really stands out among other artists, and the way he has brought singers in to feature in his songs is amazing. Definitely a great buy if you are beginning to enjoy house music.
Great Artist with better and better songs with every release!
Zedd is my all time favorite artist, he is amazing, all of his songs are great!V18 Comments
From the perspective of an avid listener to bot the dubstep and electronica genres, I was a huge fan of Pendulum's drum and bass sound and Knife Party's emergence into the electronica and club music genre has made a significant impact in my opinion. They have some really strong beats to dance to in addition to their unique sound all their own. Internet Friends is just the beginning but move into Rage Valley and the new Haunted House EP and you'll truly discover the talent these individuals possess
Knife Party knows exactly what they're doing, and what they are doing is great. "Centipede" is a staple of brutal electronic music, and the reggae beats of songs like "Bonfire" and "Give it up" are surprisingly nice combinations with electronic music. Knife Party, in my opinion, has not reached its peak, and has a long way to go.
Knife party surely is better then deadmau5 deserves a higher position then number 25. Internet friends by knifeparty is an amazing song by him and I guarantee that if people were to actually listen to him they would like him in an instant.
Knife Party should be in the top five!V11 Comments
With classics like 'smack my bitch up' and 'breathe' the prodigy should be no. 1 or at least no.2 behind daft punk. How is owl city ahead of them?
How can you put them to 8 position? They must be at the 1 position! I think this guys are more better then any other electronic group in this top 10, come on people, they are fathers of this genre!
How are these guys down here! Are you people mental? The best live act known to man and just a godly band all round ) forever prodigy
The Prodigy are the greatest of all time because they bridged the gap between alternative rock and electronica and managed to create some of the greatest electronica jams ever conceived. They are also basically the founders of the rave so most electronica artists owe their souls to the Prodigy. - DualityV30 Comments
OK, could someone please tell me why the pioneers of electronic music are on #13, under Owl City? I can't imagine someone who doesn't think Kraftwerk are the best... they should be #1 for sure!
Come on, why is Kraftwerk number 9? All of us have to at least some credit and gratitude for these guys! They were one of the most original and influential electronic pioneers and has even existed 23 years before Daft Punk!
You kids won't get electronic music if it wasn't for this genius German group from Germany! Respect the true pioneers of electronic music!
I don't think people realize that without Kraftwerk, NONE of the people on this list would be here.V28 Comments
Amazing! Love every song by these guys. Their new album Love Death Immortality is just mind blowing. Not to mention that even some of their older songs are just as amazing, like fortune days and we can make the world stop. Greatest of them all, this band.
If you don't believe they are the best, listen to "Fortune Days" by The Glitch Mob. Be prepared to have your mind-blown.
They are by far the best artist on this list, their music is perfect. They don't only do one type of song like most others do, and they are all the best.
Very good. There is some untapped talent here and I wouldn't be surprised if they were to become much bigger in the next years.V8 Comments
This guy is king with his awesome promises remix
Nero is the best! I love doomsday they should totally be at the top of this list!
Second best dubstep band.
These guys are kings at electronic if you look it up in the dictionary it will come up NEROV5 Comments
The Newcomers
The Contenders
Owl City definitely belongs to the Top 10 best electronic artists. He manages to create a whole harmonious musical world with each of his albums, mixing synthesizers and theremins to piano or guitar. The effect is a dreamy and organic world, which is pretty funny as it all comes from a computer. You need to be pretty dang talented for that. Also kuddos to him for his drums: whilst he started using real drums on his latest album The Midsummer Station, he used to sequence fields recordings and on his upcoming album, he's using kick flips. Without exaggeration, his instrumentals might be the most worked instrumentals out there - probably because before vocals, instrumental music is his original passion - and offer a brand new, yet high-quality experience after you've heard the final song. Enough about the instrumental work, though: the melodies are just GREAT. Adam Young comes up with happy, upbeat, poppy and fizzy melodies that unavoidably catch your ear and makes you want to sing, uh, ...more
Owl City AKA Adam Young has created an entirely different branch of electronica. With mesmerizing melodies, waves of emotion, and clever lyrics throughout his pieces, he spreads a type of euphoria only to be found through listening. Every time you listen, his songs take on entirely different feels and meanings, which is one of the reasons why I highly recommend him. One of the most unique artists I've found in this world of generic pop chords and incessant raps.
Adam's music is like a dream, a fantasy. It's electronic, but in a completely different way. There's nothing like it, even the Postal Service and Freelance Whales are nothing near to his music, even though at first hearing they might sound familiar. But Owl City is made of instant happiness, sheer enjoyment and overwhelming beauty.
They fill your soul with lightnessV56 Comments
This group is the new electro. They are changing things by their music and the quality of their tracks. Hard Rock Electro is the best
Justice has been definitely deserves a spot next to daft punk. With their innovative style and popular songs they definitely should not be lower than top 5.
Justice presence can't be ignored.
Unique electric music which is easily comparable to the musical quality of Daft Punk.V7 Comments
Radiohead should be way higher on this list. They completely got me into the genre of electronica. It's just real intelligent music and Radiohead are way better than Skrillex.
I admit they are more of an alternative rock band, but their electronic songs (15 Step for example) are some of their best and they deserve to be higher. - Duality
They got awesome tracks like Idioteque, Everything In Its Right Place, Where Blue Birds Fly and Feral
Radiohead is alternative rock not electronicaV8 Comments
Galvanize Hey Boy Hey Girl Believe Swoon don't Think...
The test and the private psychedelic is the best song I've ever heard in my life! The chemical brothers are always making psychedelic master pieces much greater than that of daft punk or deadmau5.
"The holy trinity" of Exit Planet Dust, Dig Your Own Hole and Surrender are without a doubt the greatest electronic albums of the past 30 years. Should be top 3 definitely, past skrillex!
Why isn't The Chemical Brothers at the top 3? If you think that skrillex thing is better you seriously need to go check your earsV7 Comments
Sorry there Captain Hipster but Pendulum IS mainstream. In Australia. Still I'm surprised that they aren't higher on the list. They're music is some of THE best out there. It's a crying shame they ended the group. Oh well. At least we have Knife Party now.
Um, how the hell are skrillex, owl city, and deadmau5 ahead of pendulum. This list is being made by people who only listen to mainstream electronic
Perhaps the furthest drum and bass from just loud noises. Bravo, Pendulum. You made real music. Good for you.
Awesome Music. Good Job PendulumV11 Comments
Moby is my favourite electronic artist. I like a lot of music in many genres, and Moby is my favourite.
Moby has highly underrated rapid electronic beats, contrasting with breathtaking ambient pieces, and has powerful and excellent vocals, and hires the guest vocalists from the very top of the list. And what better artist to see live!
His songs have catchy beats like in "Go! ", ambient beats like in "Sunspot" that take you to another world, meaningful lyrics like in "We Are All Made Of Stars" and thought provoking music videos like "In This World".
Moby never let's me down with his music. I love ALL of his albums, each one is a masterpiece, from "Play" and "18" to "Innocents" and "Everything Is Wrong".
Moby has committed a lot to his music to make it unique and excellent. I would say, with all honesty, that Moby put more into his music than the Beatles. And if you automatically vote that down, then fine, be nonsensical, you clearly don't appreciate Moby's all-round ...more - PositronWildhawk
I simply cannot believe that Moby only got 0.8% of the vote!
Seriously, Moby is so underrated things like Daft Punk are simply obsolete when you look in Moby's direction.
Where would we be without "South Side", "In This World", "Extreme Ways", "Raining Again", "Sunspot", "We Are All Made Of Stars" and several other wonders of musical genius! His upbeat electronic rock and his laid back ambient are both unbeatable!
Listen to Moby as much as you can, get the albums "Play", "18", "Hotel" and "Destroyed" and your ears will love you for all eternity!
I grew up with Moby, and all of my life, I have been trying ever since to find a music artist that is like him. So far, I can firmly say that there's no music artist quite like Moby. He is definitely my all-time favourite music artist EVER! I'm still looking for a music artist quite like Moby, and will probably not find someone quite so awesome! He is the most unique music artist I know, and definitely the best!
I've followed electronic music from. It's early days, through to the 80s synth pop, through the digital mid eighties and beyond. Moby has managed to transcend all of this, add his own style and then still come back with wonderful tracks.V7 Comments
This guy is a musical genius! At a young age, and SELF--TAUGHT, look what he can make! Just listen to his album "World." It is amazing and a truly beautiful album. Don't listen to all those copycat DJs, they flat out don't know a thing compared to Porter Robinson. He's a true musical genius, and should be at least in the top five choices. If you love electro music, please take my word and listen to his album "World." It wouldn't hurt to try
Porter's live shows are amazing. Why? He has an amazing live version of all of his songs. Look up Say My Name (Radio Edit) and the Say My Name live version, you'll hear the difference.
Porter Robinson's music quite literally takes you to another "world". He is one of the most unique artists of all time his music gets better every time you listen to it!
Language. That is all that needs to be said.V5 Comments
Avicii (when he doesn't remix his own songs) is one of the best producers in the world because unlike most of the single note bass lines and hard drops that make no sense to me, Avicii creates a really melodic Drop every single time. Avicii is #1 for me
22? Avicii is so amazing! And has made some of the best tunes, levels, I could be the one, wake me up, YOU MAKE ME! And as others below me have said he deserves higher than 22!
Are kidding me! 21?!? This is insane to see a artist with his talent sit in the back of the curtains... He has songs out there that are well known like levels. He deserves a spot in the top 10 with out a dought
Just because he is Swedish!V22 Comments
How is bassnectar not in the top 10? Nothing beats seeing him live. close your eyes take a trip and never come home
More musical talent than many of the metal musicians who inspired him
One of the best live acts ever.
Number 19? Come onV10 Comments
I'm flabbergasted Feed Me isn't in the top 10. Their hard hitting, fast-paced beats are what got me into electronica. Listen to a few of their songs like Green Bottle or Grand Theft Ecstacy and you'll understand why they deserve better than 17th place.
What the crap!?!? How can Feed me be no. 55? Everybody who reads this, go and listen to Death by Robot or Pink Lady, you'll be amazed, I'm sure of it! Thank you
Incredible talent, absolutely needs to be in top ten. Calamari Tuesday album is spot on, as with the rest of Jon Gooch's work as Feed Me.
Related ListsWorst Electronic Music Artists Best Electronic / Techno Artists of the 21st Century Top Ten Worst Songs by Good Electronic Music Artists Most Underrated Electronic Music Artists Top 10 Electronic Music Artists That Don't Deserve to Be On the List of ''Worst Electronic Music Artists''
List StatsUpdated 10 Oct 2015
251 listings
5 years, 354 days old
Top Remixes (33)
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Listen: New Band of Horses song, 'Dumpster World'
Band of Horses held a listening party for their new, still untitled album last night in Hollywood, hosted by leader Ben Bridwell.
Among the tunes they previewed was "Dumpster World," a slab of rock that starts out gentle, like a lost Crosby, Stills & Nash tune, and finishes nice and rough. Over a lilting, calm melody, the band unleashes roiling, cautionary lyrics: "Whenever you lie, well, say a prayer for people who die." Oddly, this line comes right after he's proposed.
[More after the jump...]
The one-minute clip ends with the band dissolving into laughter in the studio, asking, "What have we done?"
The collection, the band's fourth studio album, comes out Sept. 18. It was recorded over a six-week period with producer Glyn Johns at Sunset Sound Studios in Hollywood, the site of party.
The group previously debuted another new track, "Long Vows," during an acoustic set at Lollapalooza Brazil. Band of Horse's last album, the Grammy-nominated "Infinite Arms," came out in 2010.
What do you think of "Dumpster World?"
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2013 | Drama | RSummary: Leonardo DiCaprio and Jonah Hill have boundless energy in the story of a real-life commodities crook who earned millions through scummy small-time stock trades.Director: Martin Scorsese
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Cast: Tom Kane, Dee Bradley Baker, Matt Lanter
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On Thursday, September 24, 2015, ABC News reported that, "The FBI has arrested a politically prominent Chinese millionaire [Ng Lap Seng], the alleged secret source of foreign money in a campaign finance scandal during the Clinton administration, on charges he lied about why he brought more than $4.5 million in cash into the United States over the last two years."
Our August 13, 2015, OpenCdA post entitled The Clinton Family Trie (Huang , Hsia, and Riady, Too) reminded readers of the connection between the Clintons and Yah Lin "Charlie" Trie, a major fundraiser and long-time close friend of the President, who accepted a plea agreement in return for telling how he had routed illegal donations from the PRC to the Clinton Presidential Campaign. The ABC news story makes the connection between Trie and Ng.
Here is a link to the the federal criminal complaint.


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Kemba Credit Union Reviews
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- RecommendsPositive OutlookApproves of CEO
I worked at Kemba Credit Union full-time
Medical benefits Dental benefits Eye care benefits 401(k) Family-like type of business Small branches yet it is a corporate operation Honestly, there are a lot of good things about this credit union. They really do take care of their employees. They'll work with you and make sure that you are happy working for them. The people there are all really nice and helpful. They will go out of their way to make sure either they or someone else can answer your questions. And at staff meetings always expect some fun surprises! They like to give gifts just because thats how much they care for their workers. :) If I didn't have to move to a different state I would definitely still be working at KEMBA.
Minimal time off Low staff at some branches
Advice to Management
Training could be improved. I learned a lot more in the first week of the classes and when I got to my home branch; but learning how to do a job from one branch to another is overwhelming for a newcomer.
"Great Company! "
RecommendsPositive Outlook
- Work/Life Balance
- Culture & Values
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at Kemba Credit Union full-time (More than 3 years)
Kemba is an astounding company that instilled qualities that have helped me grow in my current position. Upper management is approachable and they are constantly striving to improve you both as an employee and as a person. Kemba is a credit union built on hard work that has sustained its growth due to strong leadership, a great corporate culture and outstanding involment in its community. I would recommend Kemba as both an employer and as a financial institution to anyone.
There were no challenges that I had to deal with while working for Kemba. Upper management cares about its employees, the employees are great people and the company truely puts their members first.
Advice to Management
Continue what your are doing because you have created an environment that your employees enjoy being a part of.
"Good starter opportunity with little room for growth "
Doesn't Recommend
- Work/Life Balance
- Career Opportunities
- Comp & Benefits
- Senior Management
There are some great people working at Kemba, and the credit union environment can be fun. Job security is fantastic -- I don't believe they have ever had a single layoff.
Career paths are incredibly limited. The culture at Kemba is very uptight. Kemba also has a very vertical management structure. It's also a very low-risk place, and it's averse to change.


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