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Extravagant Evening Dress
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Philharmonic of Time Dress in Black
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Pinot Noir, Please Dress in Evergreen
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Antiguo Meson de Aspeytia
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Miraculous Thorns
... in and heading upstairs. Through one of the doors to the upstairs circle, we entered the auditorium itself. The space was surprisingly minimalist and regular as far as theatres go. This is the place where the overthrown Maximilian was sentenced to death (in response to his earlier execution orders for several revolutionary leaders.) It is also where the current constitution of Mexico was signed in 1917. Continuing to take in the town, we passed some grand colonial mansions and ...
Out of the Capital
... area, the surrounding buildings took on a more chaotic and temporary guise. Colourful and pleasingly scruffy neighbourhoods tumbled over hills. We passed a large statue of a woman with arms outstretched (presumably the Virgin Mary) next to the road. Having left DF, we found ourselves travelling up and down hills through a deeply green landscape. It felt like there is very little intensive farming in this part of Mexico. There were many rustic ...
One of the most recognized Fiestas de Quer�taro for its mysticism and tradition are the Fiestas de la Cruz of the miracles begin on September 13 with a large gathering of concheros dancing their chichimecas rites for all arcs, raising the Cerro de Sangremal to reach the Temple of the ...
Everyday life as a TEC Student
... beginning of the semester you have the choice between uncountable courses and you can sign in before the regular students, so there is surely a spot in any class you want. Usually, each class takes in a lot of time. In my case, I signed in for Beach Volleyball (Tuesday, Wednesday and Friday) and for Climbing (Monday, Tuesday and Thursday). With both classes I am super happy – awesome profs and super teams. Anyhow, you have also the freedom to join any ...
Kids Back in School
... Finally, we remembered that at the corner of the market, there is a man who sells caged birds. Any birds that they can catch - cardinals, orioles, sparrows, parrots, canaries, zinzotles, doves, etc., etc. If anyone would have a hummingbird feeder, then they might. And they did! We now can watch our resident hummers funny antics, right in front of our kitchen window.
Another day, I ended up with an unexpected, crampy stomach. Moctezuma wanted to come for ...

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Product Code: X2908
Ages: 3 years & up
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Lionel Messi
June 02, 2015
Xavi hopes for 'dream' finish to Barca career with CL title
Xavi Hernandez can put the perfect finish on his Barcelona career by winning the Champions League for a fourth time in his ...
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Luis Enrique followed in the footsteps of Pep Guardiola, and now he can match his predecessor's place in Barcelona club ...
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With Lionel Messi back to his very best, Barcelona brushed aside legal troubles and Real Madrid's vigorous challenge to win ...
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Juventus draws 1-1 with Real Madrid to reach CL final
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The Latest: Juventus does it, will face Barcelona in final
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Bayern Munich must do what only team has ever done in the history of the Champions League, and overcome a three-goal deficit ...
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Still basking in its 3-0 win over Bayern Munich, Barcelona now needs to protect its lead in the Spanish league.
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|Blog Posts
Of course, anything that damages neurons can reduce the number of their tree-like processes and the density of their contact points with other neurons. The list of such causes is long, including: alcohol abuse, brain inflammation, certain infections, concussion, impaired blood supply, lack of intellectual stimulus, vitamin B12 deficiency. It now appears that we should add fragmented sleep to the list.
Common natural causes of fragmented sleep in older humans are alcohol abuse and sleep apnea. Also, in males, enlarged prostate causes a need for frequent urination. As I have explained in my learning and memory blog posts (thankyoubrain.blogspot.com), learning events during the day are consolidated into lasting form during the sleep at night of the same day. We don't know exactly how sleep helps, but obviously, you have far fewer mental distractions during sleep — unless, of course you keep waking up.
Alzheimer's Disease also causes fragmented sleep. So, it is no surprise that the brain degeneration by the disease would cause memory problems. But maybe, just maybe, it is the fragmented sleep that accelerates onset of Alzheimer's disease. Now, this seemingly ridiculous possibility has to be taken seriously in light of new research showing that sleep-disordered breathing, as in sleep apnea, seems to increase the risk of mental decline and even dementia in older women.
Disrupted sleep may also accelerate normal aging. This is certainly true when the cause is sleep apnea, which raises blood pressure and increases the cardiovascular damage that high blood pressure causes. Blood clotting is promoted, increasing the likelihood of strokes. Obesity and diabetes are often associated with sleep apnea, and it seems that sleep apnea not only results from obesity but can promote obesity and the diabetes that often accompanies obesity. Diabetes is toxic for nerve terminals. Similar neuropathy may also be occurring in their brain. Sleep apnea causes daytime sleepiness, and that it turn reduces attentiveness and mental activity, which when sustained over many years reduces the mental stimulus and promotes atrophy of neuronal processes.
Obviously, blood oxygen drops during sleep apnea. Normally, blood is 94% to 98% saturated with oxygen. But not breathing for 30 seconds or more during sleep causes oxygen level to drop to 80% or less. Any level below 90% oxygen level is dangerous, especially to the brain which demands nearly 20% of all the body's oxygen supply. The adult brain can only survive about four minutes once oxygen is completely cut off.
So it is entirely possible that the slipping memory we see in so many elderly is a warning sign of something much more serious. But by the time the memory deficits show up, much of the damage has already been done. Prevention is the best hope.
Mander, B. A., Rao, V., Brandon, B. L., Saletin, J. M., et al. (2013). Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. Nature Neuroscience doi:10.1038/nn.3324
Yaffe, K., Laffan, A. M., Harrison, S. L. et al. (2011). Sleep-disordered breathing, hyupoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 306 (6), 613-619. doi:10.1001/jama.2011.1115
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Whom Gods Destroy---It's a Bargain!
View Single Post
June 7 2013, 03:10 AM
Praetor Baldric
Lieutenant Commander
Re: Whom Gods Destroy---It's a Bargain!
plynch wrote:
Yeah, it's el cheapo, for sure. I liked it as a kid, though.
By the way, your avatar is of the most creepy guy in all of TOS, imho. "Your dad-dy can put them up. Can't. He." Almost makes the whole episode. Well, that plus red hour. Feativalll.
Praetor Baldric
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XA transaction involving resources from different networks
I have a stand-alone application that talks to several EJBs on a Glassfish v2ur2 server. The stand-alone application obtains a UserTransaction to group several EJB method calls together.
Everything works fine when I run my application in the development environment where everything is on the same network. However, when the project is deployed to the production environment where the Glassfish sever and the client are now on different networks I got a connection time-out exception when the client tries to call the commit() method of the UserTransaction object.
From what I can tell, the commit request was received by the Glassfish server. But when the server tries to send out a commit acknowledgment (I think that's what the server is trying to send), it sends it to a private IP (192.168.0.x). That explains why the client can never receive the acknowledgment in the production environment.
My question is, why is the server sending information to a private IP? Is there a way that I can correct this?
My current work-around is to use container-managed transaction. However I really want to have my client application control the transaction boundary for flexibility. Or is it a bad practice that should not be used at all?
Any comment is appropriated.
I know there was a bug in Toplink with similiar symptoms, but it is apparently not the same problem as it works fine in dev. environment for you.
Generally speaking, it is not a recommanded practice to start a transaction from the client-side. So far I know, this is an optional feature of the specifications, and not all containers will support it (especially OC4J, which would explain the issue with toplink).
Whenever possible, you should expose a facade to your client that hide the internal complexity. The methods exposed in the facade should map to your business use cases.
Concerning the IP problem, you can try to change the IP address of the IIOP listener. Instead of 0.0.0.0, try with either the hostname or the IP address. I remember we also had some issues with client installed in different subnets trying to connect to the same Glassfish instance.
Thanks ewernli for your reply.
I think for now I will go with suggestion and start the transactions on the server-side. I will probably need to dig deeper into how the transaction manager communicates with the different resources. I suspect that's where the problem is.


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Vittorio Hernandez
Doomsday prediction goes hi-tech as eBible leader warns thru podcast great fire would burn world on Oct 7, 2015End-of-the-world prophets never tire of making doomsday warnings even if they have zero credibility based on unfulfilled prophesies in the past.
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Brisbane surgeons reattach decapitated head of baby injured in car crash
Antimatter particles have been detected and we're not talking about itScientists complains about the lack of discussion on antimatters in the academe.
NASA stops support for asteroid hunt, cuts ties with private groupNASA cuts ties with private foundation that searches for near-Earth asteroid.
Aussie study that discovers 1,000 molecular changes in body during physical activity could lead to exercise pillDiscovery of what happens to muscles after physical activity could lead to creation of exercise pill.
TLC docu features Brit man born without a male genitalForty-year-old man gets a chance to have a normal functioning male genital via four surgeries.
Megatsunami Alert: Scientists warn collapse of volcano in Canary Islands could trigger massive global destructionThe latest threat to earth are possible megatsunamis likely to be caused by collapsing volcanoes in island-nations.
Telescope facilities join race in finding space objectsScientists race to discover new celestial objects, using different telescopes.
Hoax Alert: There won't be 15 days of complete darkness in November 2015Another hoax is repeated on the Internet, warning of 15 days of darkness in November because of "parallelism" between Venus and Jupiter.
Over 100 British women to be part of 2016 womb transplant clinical trialThe first womb transplant clinical trial in Britain involving over 100 women has been scheduled for 2016.
Author who spent 10 days with Jihadi John says IS planning nuclear holocaust to kill millionsShould the world take seriously the threat of a nuclear holocaust made by the Islamic State?
The future of astrophysics lies with revolutionary energies companyData mining company says market's potential of technological products is not on the gadgets but secrets the devices unlock..
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Russian scientist injects self with 3.5 million-year-old 'eternal life bacteria'Russian scientist believes 3.5 million-year-old bacteria holds key to fountain of youth.
CSIRO-led innovation to help miners save on drilling costsThe Lab-at-rig technology is expected to cut costs for miners, which could translate to cheaper prices on the market.
Medical community sceptical of Dr Canavero's planned head transplant in December 2017While doctors are sceptical of the planned head transplant, the patient is willing to risk his life to live life as a normal person.
Yale Medical School studies brain activity of healthy people who hear voicesYale hopes to discover what happens to the brain when a person hears voices, noting that between 3-7% of healthy people hear voices.
Russian scientists: Extending nuclear reactor's life to over 100 years now possibleUse of nickel alloy steel would extend life of a nuclear reactor up to 120 years.
Aussie study recommends more sex for men in their 40s for healthy prostateTo have healthy prostate glands, men are advised to have more sex, a new Australian study recommends.


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"Where Fillmore County News Comes First"
Online Edition
Friday, October 9th, 2015
Volume ∞ Issue ∞
USDA enrollment period for agriculture risk coverage and price loss coverage safety-net programs closes Sept. 30
- 9:10:55, Oct 7th 2015 - @ Concerned - I have wondered about this too. Most of the Wykoff kids don't even go t ... [Read More]
- 2:53:37, Oct 6th 2015 - Concerned - Has the school board & administration ever checked into why so many studen ... [Read More]
- 9:58:41, Oct 6th 2015 - - Why don't you run for school board, SomethingNeedsToBeDone? Write-in candidates we ... [Read More]
- 2:05:39, Oct 5th 2015 - Paul - The Quaran does not tell Muslims to kill non-muslims. In fact it says Muslims a ... [Read More]
- 1:01:48, Oct 5th 2015 - GoldenRule - Let us be mindful of the Golden Rule and how we treat others. Be careful ... [Read More]
- 11:32:26, Oct 5th 2015 - SomethingNeedsToBeDone - Are people blind?? How can they continue to use a facility ... [Read More]
- 11:23:54, Oct 5th 2015 - James1952 - Pig poker- what did you crybaby vote yes losers do both times you lost th ... [Read More]
- 10:51:29, Oct 5th 2015 - Pig poker - We all know why Jon Peterson doesn't want the school, he's mad because he ... [Read More]
- 10:37:45, Oct 5th 2015 - - Mr. Cerling(and many others), Let me start by admitting that I am beneath you in ... [Read More]
- 7:33:17, Oct 4th 2015 - Redhorse51 - Talk about drinking the Liberal Kool-Aid, WOW! WOW! WOW! Obama not a Mus ... [Read More]
October is National Pork Month: Yes I work with pigs, and darn proud of it!
Fri, Oct 10th, 2003
Posted in Features
Posted in Features
�I haven�t woke up once and not wanted to go to work. My favorite part of the job is Life being born every day."
Kim Merkel Farrowing Manager The swine industry has taken many a hit over the centuries, beginning with those who believed pork to be unfit to eat in the biblical times. The days of the pig sty and visions of these critters being fed "swill" have long since graduated to those who favor open range production, loose housing, or larger confinement units. Rural boundaries inch back as they make way for urban sprawl and the people they help feed. Manure management battles with ecology. There is an ongoing dispute over usage of feed additives and drugs to produce more products versus those who raise pork in a more natural environment. Regardless of one�s choice of farming method, the fact remains that raising quality pork is a business. And if you peel away the many layers involved in this business, the bottom line is that without those individuals who are loyal to their work, that robust, healthy, tasty, and yes, intelligent creature known as the "pig" would not thrive as well as they have today. What is the allure of working with pigs? "It�s a personal thing, you�ve accomplished something, you�ve made a difference. You treat the pig right and you�ll get paid back with a good product," explains Barb Lubenow, the Site Manager at Baarsch Pork Farm, (Next Generation Pork), owned by Kathy and Bob Baarsch, located on the Fillmore/Mower County line. "You have to have patience and be able to read the sows and pigs. It only comes with experience, you grow into it." It�s a numbers game for any manager when one must blend a team�s abilities with the animals� challenges. Lubenow feels very comfortable and proud of what she does. "I love the babies, when you leave at the end of the day, and everyone has a warm, soft spot," explains Kathy Carmen. Carmen, a part-time employee, is trained in all aspects of the operation. "There�s rewards when you�ve done your best taking care of the babies because they can be so helpless. I couldn�t raise pigs at home, so I�m doing the next best thing." She agrees it can be a very physical job, but it is worth it. "It�s an honest living. You earn every penny you make," feels Cathy Thompson. She is the site�s Breeding Manager. She and her partner, Diane Schulte, also play a numbers game . . . get those ladies bred and back in a timely manner. And when it comes to breeding gilts, (females that have never been bred), well, it�s a kind of dance while artificially inseminating that gal as her penmates try to get a piece of you. Patience is a virtue in this area of the swine industry, too. "The ability to be independent and still have a team back you is great", points out Schulte. Each person has specific tasks that are done according to their ability. Each "does their own thing " and it all comes together, whether its moving sows, vaccinating pigs, completing paperwork, or washing down crates and stalls. "People ask if it smells at the farm," said Thompson. (No, it smells like roses, she�ll mentally think). "Of course it smells, every kind of animal smells. It�s all in how you look at it." "Sometimes it�s like the show, �What�s My Line?� where someone must guess what the other person�s occupation is. "I can cleanup pretty good when I need to,� smiles Thompson. On a serious note, she is concerned that some people don�t have a clue as to where their food comes from. She feels that they need to be educated. Americans in general, are used to cheaper food sources than in anywhere else in the world. This allows more money to purchase other items in our consumer driven world. And yet, when it comes to buying groceries, how many times do patrons remark on the price of milk, beef, chicken, or pork? "I don�t think people know about the decisions we make, not everything is decreed from above," says Kim Merkel, the unit�s Farrowing Manager. After more than 20 years of working in a nursing home setting, she, and Schulte made a major change in careers. They love the challenges their new employment has brought them. Often decisions are made as one walks through the barns: Is that sow eating today? Can she handle nursing all those pigs? What�s the health of the pigs? Is the room too hot, too cold? When does the next group get weaned and who can be weaned earlier to help out starvers (runts)? That water nipple needs fixing. This pit must be emptied. I�m gone tomorrow-what can I do to make it easier for the person who is covering for me? These gilts are big enough to breed. That group of gilts should be cycling. Those nursery pigs are doing great! Merkel gets to experience the daily miracle of pigs being born. Sometimes the sow or gilt will need assistance in giving birth. A gentle hand will sleeve a pig through a difficult farrow. A finger making contact with sharp teeth while sleeving the mom is a welcome sign of life! A newly born litter reminds one of an ant hill as babies jostle for a nipple, silent at first, but quickly demonstrating their displeasure at competition. Once established, a pig will return to that nipple each time for lunch. Good management helps ensure each mouth has a dinner plate. "I think that if we weren�t doing this job, there wouldn�t be as much of a choice, nor the quality of food," says Larry Lee, Breeding Manager at Deer Creek, NGP�s second farrowing site. �It�s not a 9 to 5 job. You may have to come in earlier; you may need to stay later, to get tasks done. I do like the freedom of movement, compared to working, say, in a factory." The breeding manager says one must be open minded, open to change, as consultants and upper management strive to improve the end result of producing pork. Lee has been in the industry many years and has experienced a lot of changes. As an employee, this sorting of ideas and theories can be a challenge at times. If there�s any myths about the business, it�s that the public doesn�t always act like agriculture is necessary feels Lee. He believes there must be a continual open dialogue between those directly involved in agriculture and those who benefit from its efforts. Footnote, the author of this article worked in farrowing for six years. Her experiences have helped to foster a better relationship with her newest goal, one of milking dairy goats. Juliann Mueller can be reached at news@fillmorecountyjournal. com


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Brighter Mood Buoys Dow Rally
Blue Chips Cap Week With 267.01 Rise
Stocks burst higher on Friday, capping a sharp reversal in sentiment that has seen the Dow Jones Industrial Average climb 14% in less than three weeks.
As in previous rallies, there were few obvious catalysts for Friday's surge, which drove the Dow up 267.01 points, or 2.31%, to 11808.79. The strong finish gave the Dow its fourth week in a row in positive territory, its longest such run since January.
Friday's buying appeared to be fueled by hope that European policy makers would come up with clear solutions to the region's deepening debt crisis at meetings over the weekend and next week.
Domestic factors also played a role. U.S. companies have continued to impress analysts by topping profit expectations, with about 70% of reporting companies beating estimates.
A recent string of economic data has also emboldened a number of economists to expect a strong third quarter of growth in the U.S. gross domestic product, set for release next Thursday.
Separately, a number of Federal Reserve officials on Friday expressed their willingness to consider new securities purchases to aid the economy.
"There are a few factors at work here, and they're all hope-based," said Rebecca Patterson, chief markets strategist for J.P. Morgan Asset Management.
The change in attitude has been abrupt.
Investors entered October in a bleak frame of mind and stocks quickly fell to their lowest in more than a year, verging on bear-market territory—technically considered a decline of 20% from a recent high. And while stocks were bouncing wildly, the Dow was still locked in what is considered a "trading range," between 10700 and 11700.
"It's been a volatile ride even if you just look back two and a half weeks ago," said Ed Cowart, a portfolio manager at the Eagle Asset Management. "Three weeks ago, the received wisdom was that we're drifting off into recession, but we've gotten a lot of data in the last few weeks that has had people raising their expectations for growth."
The Standard & Poor's 500-stock index finished the day at 1238.25 and is now up 9.4% for October, on pace for its best month in more than 11 years.
For many investors, the rally is something they can't ignore, even if they aren't convinced that the outlook is brighter. Many remember 2009, when stocks zoomed higher from the March nadir, leaving many skeptical investors behind.
Some point to the recent trading activity, where stocks ping-ponged between gains and losses for 10 days. The last time that happened was in May 2009, as stocks were taking off.
Despite the good corporate and economic news in the U.S., investors remain fixated on Europe. Investors seemed to take solace in European leaders' willingness to add a second meeting next Wednesday.
On Thursday, German Chancellor Angela Merkel and French President Nicolas Sarkozy issued a joint statement promising to produce a comprehensive plan by that date. Bolstered by that news, European markets finished the week higher. The Stoxx Europe 600 gained 2.5% and Germany's DAX index soared 3.6%. The advance helped both indexes eke out a fourth weekly gain.
Despite the strong performance of late, many investors remained cautious about the stock market's longer-term prospects. "We could get a grand solution to the European debt situation that could push us up 10% to 15%, but that's a low-odds bet at this point," Mr. Cowart said. He said he still thinks the market will stay within a fairly tight range as long as investors remain skeptical of policy decisions in the U.S. and Europe.
More from MarketBeat
MarketBeat looks under the hood of Wall Street each day, finding market-moving news, analyzing trends and highlighting noteworthy commentary from the best blogs and research.
With a busy calendar of economic numbers and another flurry of corporate earnings on the horizon, investors are looking for further signs of a gathering recovery.
"I wouldn't claim victory yet," Ms. Patterson said. "I would love for hope to stay around for a while and there's a good chance it could, but until I see the details from Europe, I'm not convinced that the trend has changed. "
In earnings news, a strong earnings report from fast-food giant McDonald's helped push its shares $3.31 higher, or 3.7%, to $92.32.
General Electric GE -0.78 % pulled on the downside, falling 32 cents, or 1.9%, to 16.31 after reporting quarterly results. Chief Executive Jeff Immelt called the company's third-quarter industrial-profit margin "a low for the year" and vowed that the figure will rise in the fourth quarter and next year.
Microsoft MSFT -0.23 % edged up 12 cents, or 0.4%, to 27.16 after the software company reported higher third-quarter earnings that matched expectations, although profits in the Windows and Windows Live division declined.
Chipotle Mexican Grill CMG 0.35 % rallied 25.58, or 8.3%, to 333.49 after the casual-dining restaurant chain reported third-quarter earnings and revenue that surpassed expectations.
Honeywell International HON -1.66 % gained 2.82, or 5.8%, to 51.28 after the diversified industrial company raised its full-year earnings and revenue outlook.
Write to Jonathan Cheng at firstname.lastname@example.com and Steven Russolillo at email@example.com


text:
FT: A Bullingdon Bust-Up That Masks a Real Welfare Problem
"The enlargement of the EU and the free movement of people are both fine ideas. But, taken together, they have changed the nature of the union. A pragmatic pro-European should acknowledge that, when circumstances alter, democratic systems adapt. Changes to the welfare rules – allowing countries more scope to give priority to their own citizens – would make it easier to win the more important argument for open borders."
See more in Europe; Society and Culture


text:
Not'Art - Palazzo Giaraca
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- Suites
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TripAdvisor Reviews Not'Art - Palazzo Giaraca Syracuse
Travel Blogs from Syracuse
To the beach
... a nice and open square (who wants to eat in an open square in the middle of the sun at 35 degrees ?
We strolled through the village and then went to the beach.
Beaching seems to be a life style for most Sicilians, after some extensive searching we found a nice spot, where there were not too many weeds in the sea and installed ourselves amongst the locals.
The sea was beautiful, the water was warm - really warm- beach was sandy and you could walk for ...
Discovering the area
... we took the bus to Ortegia, which is the old part of Syracuse with a number of churches (had you thought differently) a number of palazzos, (had you thought differently) and small and dark streets with room for a scooter at best, but where the Sicilians would drive a car. It was a good idea to use the bus to get there as the streets where very small and traffic was limited. The walk was nice and specifically the ...
Further trips from Noto to baroque cities
... for the parking then, but the downside is that is deadly hot at that time. Modica is one of these towns like Ragusa where we have an old and a new part – all related to the same quake. Lots of churches, lots of stairs in the city, long walks up and down and damn difficult to get a nice picture of the nice things you see. We had lunch in a small place with a typical Modican dish (some kind of pizza but rolled with ...
Arquimedes birthplace
... br>
Hemos aterrizado en Catania y recogido nuestro Fiat Panda. Parece ser que la conducci�n en Sicilia es horrible pero como hemos visitado varios pa�ses conduciendo no nos preocupa. Pero al final es el haber aprendido a conducir en Espa�a y en Toledo en concreto lo que nos ha ayudado a sobrevivir a esta conducci�n agresiva por callejuelas estrechas.
De nuestra corta estancia en Siracusa, ...
Day 7: Simple Lighthearted Fun
... in Siracusa – only a 2.5 hour flight – now imagine that it could be so easy and convenient to transport oneself to Italy!
And oh the fish guys! They called out inviting you to see their beautiful fish. They were a bit flirtatious and I enjoyed playing along with my camera in hand – and they were just as playful back! When one fish guy posed for me with two octopus in each of his hands, the vegetable guy behind me held up some ...


text:
Page 1
Is rigorous retrospective harmonization
possible? Application of the DataSHaPER
approach across 53 large studies
Isabel Fortier,1,2* Dany Doiron,2Julian Little,1,3Vincent Ferretti,4Franc ¸ois L'Heureux,2
Ronald P Stolk,5Bartha M Knoppers,1,6Thomas J Hudson,4,7,8and Paul R Burton2,9,10on behalf of
the International Harmonization Initiativey
1Research Institute – McGill University Health Centre, Montreal, Quebec, Canada,2Public Population Project in Genomics (P3G),
Montreal, QC, Canada,3Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada,
4Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON, Canada,5Department of Epidemiology, University Medical
Centre Groningen, University of Groningen, Groningen, The Netherlands,6Department of Human Genetics, Centre of Genomics
and Policy, Faculty of Medicine, McGill University, Montreal, QC, Canada,7Department of Medical Biophysics, University of
Toronto, Toronto, ON, Canada,8Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada and9Department of
Health Sciences, University of Leicester, Leicester, UK and10Department of Genetics, University of Leicester, Leicester, UK
*Corresponding author. Research Institute – McGill University Health Centre, Allen Memorial Building, 1025 Pine Avenue West,
room P2.028, Montreal, Quebec, Canada, H3A 1A1. E-mail: firstname.lastname@example.com
yThe members of the International Harmonization Initiative are provided in Appendix.
31 May 2011
Background Proper understanding of the roles of, and interactions between gen-
etic, lifestyle, environmental and psycho-social factors in determin-
ing the risk of development and/or progression of chronic diseases
requires access to very large high-quality databases. Because of the
financial, technical and time burdens related to developing and
maintaining very large studies, the scientific community is increas-
ingly synthesizing data from multiple studies to construct large
databases. However, the data items collected by individual studies
must be inferentially equivalent to be meaningfully synthesized.
The DataSchema and Harmonization Platform for Epidemiological
Research (DataSHaPER; http://www.datashaper.org) was developed
to enable the rigorous assessment of the inferential equivalence,
i.e. the potential for harmonization, of selected information from
individual studies.
This article examines the value of using the DataSHaPER for retro-
spectiveharmonizationof established
DataSHaPER approach, the potential to generate 148 harmonized
variables from the questionnaires and physical measures collected
in 53 large population-based studies (6.9 million participants) was
assessed. Variable and study characteristics that might influence the
potential for data synthesis were also explored.
Out of all assessment items evaluated (148 variables for each of the
53 studies), 38% could be harmonized. Certain characteristics of
variables (i.e. relative importance, individual targeted, reference
period) and of studies (i.e. observational units, data collection
start date and mode of questionnaire administration) were
Published by Oxford University Press on behalf of the International Epidemiological Association
? The Author 2011; all rights reserved. Advance Access publication 30 July 2011
International Journal of Epidemiology 2011;40:1314–1328
Page 2
associated with the potential for harmonization. For example, for
variables deemed to be essential, 62% of assessment items paired
could be harmonized.
The current article shows that the DataSHaPER provides an effect-
ive and flexible approach for the retrospective harmonization of
information across studies. To implement data synthesis, some add-
itional scientific, ethico-legal and technical considerations must be
addressed. The success of the DataSHaPER as a harmonization ap-
proach will depend on its continuing development and on the
rigour and extent of its use. The DataSHaPER has the potential to
take us closer to a truly collaborative epidemiology and offers the
promise of enhanced research potential generated through synthe-
sized databases.
Data synthesis, data quality, data pooling, harmonization, meta-
analysis, DataSHaPER, retrospective harmonization
In order to properly understand the role of, and inter-
action among genetic, lifestyle, environmental and
social factors in modulating the risk of development
and/or progression of chronic diseases, it is critical
that analyses have adequate statistical power.1,2
Moreover, the aetiological relations of interest are
generally complex and the risks targeted often rela-
tively weak.1,3Scientific progress thus demands access
to very large databases4providing comprehensive,
valid and precise information on a variety of factors
and disease traits.5Due to the financial, technical and
time burdens related to developing and maintaining
very large studies, the scientific community is increas-
ingly making use of the synthesis of data to address
the limitations of statistical power of individual stu-
dies.6In turn, however, when an analysis is to be
undertaken based on individual-level data integrated
between studies, the key data items assessed in indi-
vidual studies (e.g. specific measurements or ques-
tions) must not only be measured well, but the
information they convey must also be rendered 'infer-
entially equivalent' (or 'harmonized').7A fundamen-
tal tension therefore lies between increasing sample
sizes by synthesizing data from many individual stu-
dies, and restriction of the data synthesis to those
studies that are satisfactorily harmonized and which
providea commonset
Given the quantity and complexity of the informa-
tion generally collected by individual established stu-
dies and the heterogeneity of their designs and
procedures, it is essential to have access to effective
methods and tools to formally explore the potential to
generate high-quality synthesized databases. Such
tools need to provide comprehensive information on:
(i) the specific variables that could be shared; (ii) the
of scientificallyvalid
studies that could participate in targeted analysis; and
(iii) the factors that could influence the potential to
integrate information.
Research (DataSHaPER; www.datashaper.org) may
be used to provides such information.7It includes
two primary components. The DataSchema8docu-
ments and annotates sets of core variables, which
each provides a concise but effective list of informa-
tion to be harmonized in a specific scientific context.
The Harmonization Platform then provides a template
for the formal estimation of the potential to synthe-
size information across networks of studies. In collab-
oration with other Public Population Project in
Genomics (P3G) partner teams9–12and projects,13,14
developments are currently ongoing to build a suite
of tools supporting all steps of individual data har-
monization, synthesis and analysis.
The current article evaluates the value of the
DataSHaPER as a foundation for retrospective har-
monization. It focuses on the Generic DataSchema
that is composed of variables aimed at supporting
the construction of general purpose baseline question-
naires andphysical measures
population-based studies enrolling adult participants.7
The specific aim of the article is to investigate and
quantify the potential for harmonizing variables that
make up the Generic DataSchema questionnaires and
physical measures modules7across more than 50 of
the world's largest population-based studies. The art-
icle also investigates factors that might influence the
potential for harmonization, particularly the basic
study design and nature of individual variables, as
well asevaluating the
DataSchema as a platform for harmonization of exist-
ing databases. The article will help guide future de-
velopment of the DataSHaPER project.
The DataSchema
foruse in large
utility ofthe Generic
Page 3
Selection of variables
Development of the Generic DataSchema has been
centred on a series of international consensus work-
shops bringing together experts from more than
25 studies and 14 countries. Its construction was
based upon iterative review and consensus methodol-
ogies15,16aimed at synthesizing knowledge and input
from practitioners and researchers with a variety of
professional expertise. The primary objective was to
generate a select list of core variables that would pro-
vide a valuable contribution to the baseline interviews
of population-based studies enrolling adult partici-
pants and provide a basis for harmonization. Agreed
selection criteria were defined and used, first, to select
broad domains and, then, specific variables.7Where
possible, variables were chosen and defined so as to
be compatible with widely used international classifi-
cation systems or standards.17–19Over a 3-year period,
iterative rounds of discussion and comment contrib-
utedto gradualrefinement
DataSchema. In particular, a number of cohorts pro-
vided critical feedback based on their own use of early
versions of the DataSchema as a foundation for ques-
tionnaire development. These included Lifelines20
(The Netherlands), LifeGene21(Sweden), the five co-
horts in the Canadian Partnership for Tomorrow
Project14and the Canadian Longitudinal Study on
Aging.22The Generic DataSchema remains a dynam-
ically evolving tool that is improving incrementally
over time based on users' feedback and increasing
scientific knowledge.7
The ontology of the Generic DataSchema has a hier-
archical structure in which the selected variables (the
fundamental units of a statistical analysis, such as:
lifetime occurrence of cancer; highest level of educa-
tion; diastolic blood pressure) are grouped under do-
mains (e.g. individual history of cancer, education
level, blood pressure) that are themselves distributed
across themes (e.g. individual history of disease,
socio-economic status, body function measures) and
modules (health and risk factor questionnaire, phys-
ical and cognitive measures and interview administra-
tion).7Only the health and risk factor questionnaire
and the physical and cognitive measures modules
were considered for harmonization. Basic interview
administration information (e.g. date of birth, date
of interview, sex, language and location of interview)
was collected by participating studies but not neces-
sarily through collection modes targeted by the cur-
rent exercise. Hence, even though all studies could
share constructs derived from these data (such as
age), this module was excluded from the current har-
monization exercise. Within the physical and cogni-
tive measures module, contraindications to having a
particular measurement were also excluded from the
harmonization process, since we did not have access
to consistent information on the specific contraindi-
cations targeted by studies.
of theGeneric
Selected variable characteristics that might influence
the potential for data synthesis were documented.
These include: (i) its importance for broad-based re-
search projects as perceived by expert consensus (es-
sential, important,useful
individual targeted by the variable (the participant
himself/herself, the participant's family members)
and (iii) the period of the participant's life to which
the variable refers (current status at assessment, all
other periods). Classification of the perceived 'import-
ance of variables' was based on their relevance to be
part of a generic set of information useful for a broad
range of research questions. Since this classification
was subjective, it was undertaken by two separate
experts followed by comparison, and final confirm-
ation by a panel. As an illustrative example, the fol-
lowing variableswere
occurrence of cancer (participant); 'important': occur-
rence of cancer in the family; 'useful': occurrence of
cancer in siblings.
information),(ii) the
classified as:'essential':
Selection of participating studies
Potential studies to be included in the harmonization
process were identified using P3G's collaborative net-
work and Study catalogue (www.p3gobservatory.org).
Eligible studies were those that had: (i) recruited or
planned to recruit at least 10 000 adult participants;
(ii) collected biological samples enabling DNA extrac-
tion; (iii) collected comprehensive information on life
habits, socio-economic status and health outcomes;
and (iv) provided access to the baseline questionnaire
and standard operating procedures used. Priority was
given to studies with the largest number of partici-
pants, those that were initiated most recently and
those that had questionnaires available in English or
French. A total of 87 studies were initially ap-
proached. Of these, 53 agreed to participate; 6
declined and 28 did not respond to our contacts.
Key characteristics were documented in order to
identify study-related factors that might influence
the potential for synthesis. These were: (i) study
design (cohort or cross-sectional); (ii) breadth of sci-
entific focus (broad scientific focus or focus on spe-
cific outcomesor exposures);
population sample (general population or specific sub-
population such as clinic out-patients, professional as-
sociation,etc.); (iv)participation
participant or participant selected from a pre-existing
study); (v)observational
families); (vi) sex (whether one sex only or both
sexes were included); (vii) region of residence of the
participants (Europe, North America or other); (viii)
lower limit of participants' age at recruitment (<25,
25–40 or 440 years); (ix) data collection start date
(before or in 2000 or after 2000), (x) targeted
number of participants (less than 100000 or 100000
or more); (xi) proportion of participants from whom
biological samples were collected (a subsample or all
participants); (xii) mode of administration of the
(iii) source of
history (new
units (individualsor
Page 4
mixed); and (xiii) site of administration of the ques-
tionnaire (participantresidence,
centre or mixed).
(computer based, paperbasedor
Harmonization process
Using the 53 participating studies, an initial evalu-
ation was undertaken in order to determine if the
selected Generic DataSchema domains correspond to
risk factors and outcomes most frequently collected in
current practice. This was done using the keyword
tree of the P3G questionnaire catalogue, which pro-
vides a comprehensive overview of the areas of infor-
mation collected by large epidemiologic studies.23
Each DataSchema domain was attributed a corres-
pondingkeyword of the
'DataSchema domain', Individual history of Cancer;
'Keyword', IndividualHistory
International Classification of Diseases (ICD)]. The
proportion of the 53 participating studies collecting
information on each keyword (i.e. coverage) was
determined. This then allowed examination of the
extent to which areas of information that were se-
lected to be part of the Generic DataSchema (i.e. key-
words corresponding to DataSchema domains), or
not selected(i.e. keywords
the DataSchema), were used in current practice. The
result of this analysis will help to optimize the
Generic DataSchema by adding or deleting specific
domains of interest based on their coverage among
the world's leading population-based studies.
As the primary harmonization exercise, the potential
for each study to generate each variable included in
the Generic DataSchema was evaluated. Once specific
definitions have been attributed to each variable, the
harmonization approach entails using a three-level
scale to document the compatibility between the in-
formation generated by the assessment items of each
keywordtree [e.g.
of Neoplasm—
participating study (e.g. specific questions) and each
variable defined in the DataSchema. This process is
referred to as 'pairing' (Box 1).7In order to classify
the assessment items and to ensure the validity and
reproducibility of the pairing results, sets of compre-
hensive 'pairing rules' specific to each variable are
defined.7Development of pairing rules is context spe-
cific and involves a systematic process of iteration be-
tween scientific experts and trained research officers.
Using these pairing rules, trained research officers de-
termine whether or not a variable can be recreated
using the assessment items collected by each partici-
pating study. In order to ensure quality control, an
evaluator verified a random sample of ?10% of all
pairing results. Whenever a pairing error was de-
tected, a consensus panel determined the final pairing
Statistical methods
The chi-square statistic was used to test for difference
between thecharacteristics
non-participating studies. Study and variable charac-
teristics were documented using descriptive statistics
for binary and nominal variables including tabulation
and reporting of counts and percentages. Coverage of
areas of information that had been selected or not
selected to be part of the Generic DataSchema were
compared using the non-parametric Wilcoxon rank
sum test.24Cohen's k statistic25was used to evaluate
agreement between the research officers conducting
the initial pairing and the final validated results.
Primary analysis was based on the standard un-
weighted k statistic25but, because the classification
categories were ordered, two alternatively weighted
k statistics26were also used.
Analysis of the study- and variable-level character-
istics that systematically influence the likelihood that
a given variable can be created from the assessment
ofparticipating and
Box 1 Classification of the level of compatibility between assessment items and DataSchema variables. (For a detailed
example, please refer to Fortier et al.7)
According to the pairing rules, the meaning, format and standard operating procedures used for collection
of the assessment items allow construction of the variable as defined.
PartialAccording to the pairing rules, the meaning, format and standard operating procedures used for collection
of the assessment items allow the construction of the variable as defined, but with an unavoidable loss
of information. This class includes two subcategories:
'Proximate'—when the only reason for the classification as partial is because categories are used to collect
information for a DataSchema variable that is defined as continuous.
'Tentative'—whenever a variable is classified as partial for any other reason.
Impossible When no relevant information is collected (impossible not covered) or, based on the pairing rules,
insufficient information exists to construct the variable as defined (impossible covered).
aIn certain instances, a DataSchema variable is not pertinent in the context of a particular study (e.g. the 'Occurrence prostate
cancer' variable in the context of a study recruiting only women). In such cases, the variable is classified as 'Not applicable' for
that study.
Page 5
items of a given study was undertaken. This analysis
was used to identify factors that influence potential
for data synthesis and was based upon a type 1 gen-
eralized estimating equations (GEE) analysis,27,28
which takes appropriate account of the correlation
of variables within studies. The analysis was based
on a logistic regression model with an exchangeable
correlation structure. Robust standard errors were
used throughout.
Participating studies
Among the 87 studies contacted, no association was
observed between study size or region of origin and
the likelihoodof participation
However, studies that launched recruitment of partici-
pants after 2000 were more likely to respond to our
call to participate [P<0.05, odds ratio (OR)¼2.73,
95% confidence interval (CI)¼1.11–6.71]. Fifty-three
studies accepted to participate, encompassing 6.9 mil-
lion participants, recruited or to be recruited. Of the
participating studies (Supplementary Data available at
IJE online), 48 are designated as cohorts and 5 had
cross-sectional designs. Most studies had a broad sci-
entific focus (42 studies), enrolled new participants
family—as the unit of observation (47 studies) and
included both sexes (46 studies). Participants were
recruited from the general population in most studies
(44 studies). However, some (nine studies) targeted
population subgroups such as professional associ-
ations, clinic out-patients and at-risk individuals (ex-
posure or disease). The start dates for collection of
information range from the mid-1980s to 2010. Five
studies began collecting information in 1990 or before
and 18, 10 and 20, respectively, in 1991–2000,
2001–05 and 2006–10. Study sizes range from 10000
to over half a million participants. Eight have already
recruited, or aim to recruit, 500000 participants or
more, whereas the majority (28 studies) have a par-
ticipant recruitment target of 50000 or less. Thirty
studies have collected or plan to collect biological
samples from all participants, whereas the others col-
lect samples from a subgroup of participants only.
A total of 26 studies recruit participants from
Europe, 17 from North America, 5 from Asia and 5
from Australia. Different data collection modes are
also used. For example, 24 studies are using paper-
based questionnaires and 13 used computer-based
questionnaires; the rest used a mixed data collection
inthe initiative.
Generic DataSchema
Areas of information
In order to confirm that the Generic DataSchema does
provide effective coverage of areas of interest to a
generalpurpose population-basedstudy,andin
order to assess its use in actual current practice, all
53 participating studies were keyword coded. The key-
words themselves were categorized into those that do
correspond to a Generic DataSchema domain and
those that do not. The proportion of studies that cov-
ered each keyword was then calculated and plotted
(Figure1). Keywords
DataSchema domains are covered, on average, by
75.9% of studies, whereas keywords that do not are
covered by 25%. The mean difference of coverage was
thereforeestimatedat 50.9%
CI¼42.2–59.2). Furthermore, all keywords covered
by at least 78% of participating studies correspond
to DataSchema domains (Figure 1). However, even
if the DataSchema includes areas generally used in
current practice, a few exceptions are noted. For ex-
ample, the 'Subject family's birth location' keyword is
included in the DataSchema, but is only covered by
34% of the studies. Similarly, 'Familial diseases of the
respiratory system' and 'Familial mental and behav-
ioural disorders' (ICD10) keywords are also in the
DataSchema, but only covered by 36 and 38% of the
studies, respectively. On the other hand, 'Individual
disease of the genitourinary system' (ICD10) and
'Individual disease of the digestive system' (ICD10)
are covered, respectively, by 75 and 77% of the stu-
dies, but are not included in the DataSchema.
that do correspond to
All 148 Generic DataSchema variables encompassed
by the questionnaire and physical measures modules
were included in the pairing exercise. Among the vari-
ables paired, 38 were classified as 'essential' for broad
focused epidemiological research, 45 were considered
'important' and 65 were deemed 'useful'. A total of
101 variables (68%) target information directly related
to the participant (e.g. Occurrence of menopause,
Height), whereas 47 (32%) target the participant's
family (e.g. Occurrence of diabetes in siblings).
Forty variables (27%) target information related to
the time at which the assessment took place (e.g.
Current smoking status), whereas the remaining 108
variables target information relating to other time
periods in the participant's life (e.g. Age at first
Harmonization results
The overall pairing process shows that 36% of all as-
sessment items paired (148 variables paired for each
of the 53 studies) were classified as 'Complete', 3% as
'Partial Proximate', 14% as 'Partial Tentative', 47% as
'Impossible' (7.2% 'Impossible Covered' and 40.2%
'ImpossibleNot Covered)
Applicable'. See Box 1 for definitions of pairing clas-
sifications. Some continuous variables, defined as
open-ended in the Generic DataSchema, simultan-
eously show a very low proportion of 'Complete'
matches and a relatively high percentage of 'Partial
Proximate' matches (e.g. Household income—4%
and 0.2% as'Not


text:
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Nathan Argent is the Policy Advisor for Greenpeace New Zealand based in Wellington and is a long time Greenpeace campaigner with an interest in clean technology solutions.
If you go down to the concrete jungle today, you're sure to get a surprise. If you're in town to cut some deals, you'll never believe your eyes.
For there's a bear who shouldn't be there. Because she's losing her home in the Arctic.
Yesterday the government delivered a Budget with a deficit in ambition. It completely failed to back our clean energy innovators. Today, at Skycity in Auckland, the Prime Minister met with a bunch of business executives. And no doubt there was some back-slapping and high fives all round.
Pastries, cheese scrolls and sausages on sticks were scoffed as John Key wandered around shaking hands. Maybe the National party coffers might even see a little boost too from the assembled suits.
A climate refugee in #Auckland has come to John Key's post budget briefing - climate change can't be ignored #nzpol pic.twitter.com/WtUq8E0a2I Read more >— Greenpeace NZ (@GreenpeaceNZ) May 15, 2014
A climate refugee in #Auckland has come to John Key's post budget briefing - climate change can't be ignored #nzpol pic.twitter.com/WtUq8E0a2I Read more >
But the polar bear was also trying to get into the room to remi...
Yesterday, the Green Party launched a pre-budget policy … "as a first step in accelerating New Zealand's transition to a smarter greener economy" …but from what we've seen so far, there a few glaring issues with how they propose to get the green economy into the black.
They've said they would set up a "Green Investment Bank", if they get into government. The bank would use public funds to leverage private investment, in order to rewire our economy and harness New Zealand's clean energy expertise. Co-leader Russel Norman argues it could reduce pollution, create jobs and deliver solutions to environmental problems like climate change.
And as was pointed out, New Zealand would not be the first to create such a bank. Many of our trading partners in UK, Germany and the US have successfully set...
Now that the Internet Party are up and running, and if the latest polls are anything to go by, gaining some tailwind, they've today announced their environmental policy.
And as part of our election year review of party policies and attitudes towards the environment, it seemed only reasonable to offer our considered thoughts on Dotcom's latest contribution to the political mix.
Dotcom's Internet Party unveils environmental policy: Kim Dotcom's fledgling Internet Party has begun fleshing... http://t.co/0Rtxc2ZsVw— nzherald National (@nzheraldnznews) May 9, 2014
Dotcom's Internet Party unveils environmental policy: Kim Dotcom's fledgling Internet Party has begun fleshing... http://t.co/0Rtxc2ZsVw
Let's write a new set of rules for the environment. Help us write the best policy ever: http://t.co/Y7n8iWkVHe #Environment #Sustainable Read more >— Internet Party (@InternetPartyNZ) May 8, 2014
Let's write a new set of rules for the environment. Help us write the best policy ever: http://t.co/Y7n8iWkVHe #Environment #Sustainable Read more >
Firstly, it's good to see that that the party has recognised the enormous opportunities that doing things in a cleaner smarter way could bring to New Zealand.
And perhaps it's no surprise that there is an emphasis on green data centres. The advances being made globally in this sector are happening at an ultra-fast pace as companies like Facebook and Google look to power their global reach w...
So Shane Jones is off. Retired from politics he says. Couldn't give 100 percent to the cause so he did what he thought was best for the Party.
Shane Jones has always been a polarising figure and never more so when it comes to his dislike for us: "the Green Priests". We've clashed on many issues, most notably his pro-oil and gas stance and his support for destructive fishing in the Pacific. We spoofed a Sealord video, highlighting the impact the company was having on our oceans. Much like an oil spill, his rage washed up on the telly as he leapt to the defence of his former paymasters who had given him 10 grand in 2011.
And now Parliament's resident firebrand is chasing the money once again and seemingly selling out to National.
So often Jones has tried to publicly re-write Labour party...
This month is the fourth anniversary of the start of negotiations on the Trans-Pacific Partnership Agreement or TPPA. To mark this occasion there are going to be protest rallies all over New Zealand on Saturday March 29th, calling for an end to the deal.
The Trans-Pacific Partnership Agreement (or TPPA) has been talked about in the media for several years now – there's a good chance you've already heard about it and you may already have joined a protest or signed petitions against it – but the details of the deal don't get any less shocking with time or familiarity.
Essentially, the TPPA is an international 'trade agreement' that could hand foreign corporations the power to overturn NZ laws if their profits are threatened. It's bad news.
Here's an example of what this could look like i... Read more >
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|Product #: SED12150_TQ
Popocatépetl and Iztaccíhuatl (Resource Book Only) eBookGrade 2|Grade 3|Grade 4
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This is a true love story centered in an ancient Aztec city. It begins with a sweet princess who wishes to marry a noble commoner, but of course, the emperor only wants her to marry a victorious warrior. Who will prevail-the good guy or the bad guy?
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|Search | About | Preferences | Interact | Help
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by John D. Wagner
Publisher:Creative Homeowner
Drywall: Pro Tips for Hanging & Finishing will teach any reader to install and repair drywall with the confidence of a professional. With 445 detailed drawings and photographs, Drywall leads the reader, step by step, through the processes of measuring, cutting, installing, and finishing drywall ceilings and walls. In addition to standard drywall practices, the book also covers more advanced topics such as applying drywall to curved walls and installing drywall over steel studs. Corner treatments and the specialized tools used to install drywall are also covered. Get the inside track on working with drywall with special tips from professional drywall contractors.
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Overall: 5.0 / 5 based on 6 reviews
6 of 6 reviewers would recommend this product to a friend.
Excellent Hy-Fote Gel -
By: FarandFine from Alexandria, VA
Top 10 Contributor
As I noted in a review of the Orvis floatant system, the Hy-Flote gel is real gem of the system. It works best when applied to dry flies before fishing, and doing so enables them to ride higher and float longer before becoming saturated. When they do become saturated, I dry them using an amadou pad followed by a reapplication of the Hy-Flote gel. For best performance, simply rub a small dab of the gel between your fingers to warm, then rub the gel into the fly (especially the hackle) until absorbed. Tight lines.
Formerly skeptical -
By: Sandyman from Taos, NM
Top 500 Contributor
I had reservations about this product never having used it before, but the Hy-Flote Gel works. For me it allows me to see my stimulator fly more easily as it tumbles through swift water while the nymph does it's work.
Excellent Floatant -
By: NNCC from San Jose, CA
Top 10 Contributor
Keeps the fly floating longer than many gel floatants I've used over the years. The best thing is that the consistency isn't affected by temperature changes too much. I've used too many that turn to liquid in heat and turn almost solid in cold. This doesn't have that problem.
A must have -
By: ADKtrout
Top 1000 Contributor
This product is great for use with dry flies, especially when used in conjunction with a high quality powdered floatant. I use it to start a fly off and then switch to powdered floatants after getting it wet for a while. I couldn't be happier with this product.
A Must Have -
By: Castaway from North Ga
Top 50 Contributor
It is a must have for dry flies. It last a long time and doesn't mess up the fly up at all.
A must have -
By: Joon from Hawaii
This product is a must have for any dry fly fisherman. Great product!


text: http://forums.fedoraforum.org – I just purchased a new Toshiba Satellite notebook. Through testing F16 Xfce (live cd) and then install, and then updating and playing around with my new system, the battery sat at 0% charge. At about an hour in, I checked the battery (removed) and checked the charge point. All seemed good (nothing over heating and clean connections). After one and half hours, the battery started taking a charge. I am relieved and happy at this, but wondering if I am doomed to a battery with a short life (in need of replacement soon). To my understanding, device batteries are supposed to be shipped with a (HowTos)


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Franklin - Someone jumped over a fence topped with razor wire so they could break into five loaded trailers at FedEx Freightways, 10613 S. 27th St., between the late evening hours of Feb. 9 and early morning hours of Feb. 10, according to a Franklin police report.
Also in the report:
The person broke the cast iron locking hook with an object, which allowed him or her to open the trailer door. An estimate of damage to the trailer doors was unavailable at the time of the report.
Two of the trailers were filled with pallets, one was filled with pamphlets for printing, one was loaded with refrigerators and one had end-cap displays for the DVD "Game of Thrones," including DVD games.
Nothing was stolen from any of the trailers.
Franklin police are conducting extra patrols in the area, and an investigation is ongoing.
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The Bald Soprano was Eugene Ionesco's first play, performed in 1950 at the Th (c) tre des Noctambules. At the time, Ionesco had been learning to speak English by copying sentences from an English primer. As he copied the simple phrases over and over again, the absurdity of language struck him. He translated this experience into The Bald Soprano, which satirizes the deadliness and idiocy of the daily life of a bourgeois society frozen in meaningless formalities. The Bald Soprano had a 1987 production in New York City, a production with the Shakespeare Theatre of New Jersey in 2007, and an Off-Broadway production in the spring of 2009 with the One Year Lease theatre ensemble.
In The Chairs, the Old Man and Old Woman are setting up chairs in anticipation of the arrival of a series of guests who are coming to hear an orator reveal the old man's discovery of the meaning of life. Once the couple has convinced themselves that a crowd is assembled (when in fact there are only empty chairs) the evening progresses to a frantic, menacing climax. The Chairs was first produced in 1952 at the Th (c) tre Lancry. After receiving a 1997 London production, The Chairs returned to Broadway in 1998 and garnered five Tony nominations.
Eugene Ionesco, 1912-1994, is one of the foremost playwrights of the Theatre of the Absurd. The son of a Romanian father and a French mother, he settled in France and eared his living as a proofreader for publishers, coming to playwriting almost by chance. Having decided to learn English, he was struck by the emptiness of the cliches of daily conversation that appeared in his phrase book. Out of such nonsensical sentences he constructed his first play, The Bald Soprano (1950; Eng. trans., 1958). Greatly surprised by the success of the play, Ionesco embarked on a career as a writer of what he called 'anti-plays', which characteristically combine a dream or nightmare atmosphere with grotesque, bizarre, and whimsical humor. His work includes The Lesson (1951), The Killers (1958), Rhinoceros (1959), Exit the King (1962), Notes and Counternotes (1962), A Stroll in the Air (1963), Hunger and Thirst (1964), Fragments of a Journal (1966), Journeys Among the Dead (1980), theoretical writings, and the novel Le Solitaire (1973).
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It was quiet. Bed was comfortable. Breakfast was good...coffee especially good.
Hallways were dingy...concrete floor was stained. Stairways were dingy. Needs some upgrading in these public areas.
The staff was wonderful
The pool was small and overly warm.
Toilet clogged on arrival. Tacky sticky notes on headboard
Stating sheets clean. Duvet cover scratchy and not warm. Staff not so friendly. breakast unappealing.
Nothing. The accommodations were unacceptable. The entire hotel reeks of tobacco smoke.
We left. Couldn't stand the smell. And we've been fighting with the hotel manager trying to get our money back. They have been rude and uncooperative.
The room was very clean. Housekeeping was very accommodating.
Some of the staff could have been friendlier. The hotel itself was outdated. The hallways and lobby area smelled like cigarette smoke at all times. The continental breakfast included cereal, toast, a danish, or frozen waffles.
The staff there is very friendly. We have stayed in this hotel for this particular weekend for the last 3 years and have always felt welcome. Our accommodations were fine for the price we paid. We will definitely stay here again!
Unfortunately when we booked this room there was only smoking rooms available and we are non-smokers. But we chose to stay anyway. The room was very smokey smelling. We had to air out our luggage when we got home because it reeked.
Location, quiet
No coffee maker in room. No breakfast.
They need to vacuum under the bed! The box spring was broken with a board sticking out the bottom. Bed could have been more comfortabl.
Nice running shower.. The door to room was squeaking terribly so I asked maintence for WD40 and he was very accommodating to give me what I asked for.. But didn't offer to doThe second room that was given was a lot better.. But still had issues.
The room that I thought I was getting had couch in the standard queen picture shown on Howard Johnson's website.There was no couch and the first room was horribly filthy! Bugs smelly and human secretions on bedspread!! Was transfer to another room!!!1
The room was designed well. You walk through the door into the living room and the bed room is down a hall through a door. You have access to the bath room with out going into the bed room. When your kids go to bed early, this is a great set up!
No full kitchen in the room
Beds were comfy, linens were clean
Pool was cloudy and gave my son pseudomonas foliculitis, gross!!
There were at least 10 scary looking German shepherds in training to become border patrol, drug sniffing, ATF etc, that were impossible to avoid bc they needed bathroom breaks and were constantly being taken by their owners through the lobby
Comfy beds, good size bathroom, microwave and refrigerator, pillows seemed OK I always travel with my own extra kudos to Hotel Employee on the front desk.
no plates or utensils in mini kitchenette.
Great staff and accomodations. Perfect for family travel.
Very dirty bathroom and towels were stained with a black substance. The fitness center was out of the 80's
Overall I'm just hoping I didn't get bed bugs staying here
I don't have anything nice to say about my stay.
Hotel tried to charge an additional $10 for the room I reserved, stating there was an error with the online booking agent. Got a room with double Queen beds instead of the King I had reserved to avoid paying anything additional. Room was on the ground floor next to a parked refrigerated food carrying tractor trailer which was idling, I could hear it all night. Room was tidy but the coffee machine had an old spill of coffee on the bathroom counter. All the towels smelled of a combination of dust, fresh paint, and cigarette smoke. Noticed the towels after drying my face after getting out of the shower.
Here's why:
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i tie it on mine. i do the knot about 1 1/2 feet from the buckle
i tie it on mine. i do the knot about 1 1/2 feet from the buckle
I've used my buckles with my Stapworks poly webbing. I tie a loose enough slippery hitch so it doesn't make the webbing go into buckle crooked but, it's there in case it slips.
P.S. It hasn't slipped yet.
"In your face space coyote"-HJS
i've had 1000 LBS on them with no slipping at all.
At 260 my experience with the WBBB cinch buckles is they lock into place and will not budge. In fact if I tighten up the suspension too much they are very tough to loosen up. Complete trust here and no knot.
Mark is the name and If there is more than one way to understand what I just said....I meant the good one.
Earth First! We'll dirt bike ride the other planets later.


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Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
- Equal contributors
1 Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium
2 Institute of Physiology and Zürich Center for Integrative Human Physiology (ZIHP), University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland
3 Department of Biomolecular Sciences and Biotechnology, University of Milano, Via Celoria 26, I-20133 Milano, Italy
4 Department of Physics, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium
5 Department of Physics, University of Genova, Via Dodecaneso 33 I-16146 Genova, Italy
6 INSERM U779, University of Paris 11, Hopital de Bicetre, Le Kremlin Bicêtre, 94275, France
7 Zoophysiology, Department of Biological Sciences, Aarhus University, C F Møllers Allé, Bygning 1131, DK-8000 Aarhus C, Denmark
8 Department of Biology, Ghent University, K L Ledeganckstraat 35, B-9000 Ghent, Belgium
BMC Biochemistry 2010, 11:17 doi:10.1186/1471-2091-11-17Published: 2 April 2010
The genome of the nematode Caenorhabditis elegans contains more than 30 putative globin genes that all are transcribed. Although their translated amino acid sequences fit the globin fold, a variety of amino-acid substitutions and extensions generate a wide structural diversity among the putative globins. No information is available on the physicochemical properties and the in vivo expression.
We expressed the globins in a bacterial system, characterized the purified proteins by optical and resonance Raman spectroscopy, measured the kinetics and equilibria of O2 binding and determined the crystal structure of GLB-1* (CysGH2 → Ser mutant). Furthermore, we studied the expression patterns of glb-1 (ZK637.13) and glb-26 (T22C1.2) in the worms using green fluorescent protein technology and measured alterations of their transcript abundances under hypoxic conditions.GLB-1* displays the classical three-over-three α-helical sandwich of vertebrate globins, assembled in a homodimer associated through facing E- and F-helices. Within the heme pocket the dioxygen molecule is stabilized by a hydrogen bonded network including TyrB10 and GlnE7.GLB-1 exhibits high ligand affinity, which is, however, lower than in other globins with the same distal TyrB10-GlnE7 amino-acid pair. In the absence of external ligands, the heme ferrous iron of GLB-26 is strongly hexacoordinated with HisE7, which could explain its extremely low affinity for CO. This globin oxidizes instantly to the ferric form in the presence of oxygen and is therefore incapable of reversible oxygen binding.
The presented data indicate that GLB-1 and GLB-26 belong to two functionally-different globin classes.


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New Products
The startup Dovie, Inc., has come into existence to give you one thing: dovie.tv—an enterprise-grade on-line video platform with built-in HTML5-ready players, Flash-free playlist embeds, analytics and advertising. The SaaS platform, says Dovie, offers a video control cloud with enough power to launch an on-line TV show, channel or network from a desktop computer, and it is simple and affordable enough for almost anyone to use. That power is complemented by the platform's tools that focus on making on-line video management and monetization accessible to everyone from mom-and-pop shops, to mid-market entrepreneurs, to enterprise-level professionals. Dovie also comes plugged in to major ad networks and ready-to-run CPM-optimized pre-roll video spots. Commercial content is welcome and doesn't require video producers to relinquish any rights to use the system.
The new PC maker, Recompute, is now offering Linux-based, OS-free and Windows-based desktop computers that offer a fresh approach to sustainability during the entire product life cycle. The company's approach is based on an intensive study exploring the most sustainable way to produce, use and dispose of PCs. Surprisingly, Recompute cases are manufactured of (recyclable and renewable) corrugated cardboard and treated only with nontoxic glues and flame retardant. To avoid the waste of electronic components that the user doesn't need, only memory, power supply and a hard drive come standard, while the eight USB ports allow the user to accessorize as needed. The design philosophy further allows for easy dismantling and sustainable local recycling, avoiding the typical fate of hard-to-handle e-waste from PCs: exporting it to poor countries where its processing does tremendous damage to people and the environment. Recompute states that its goal is to change how we deal with our dead computers and hopes that others will follow their lead. The effort makes you wonder why more Linux gurus aren't in charge.
Raising the next generation of creative geeks is serious business, and since Dr Spock never wrote the definitive guide to geek parenting, we're on our own. If Spock were alive, he might hand you David Erik Nelson's new book Snip, Burn, Solder, Shred: Seriously Geeky Stuff to Make with Your Kids. Snip is a book of geeky, do-it-yourself crafts and toys that one can make for $10 or less. It includes illustrated, step-by-step instructions for 24 projects, such as water-powered bottle rockets, an oversized joy buzzer that (safely) administers a 100-volt jolt, booming thunderdrums made from salvaged x-ray film, a cigar-box synthesizer, a powerful muzzleloader that shoots marshmallows, homemade board games and more. As the readers build, they learn the basics of carpentry, sewing, circuitry and soldering. No technical experience is required, and the projects won't break the bank.
Please send information about releases of Linux-related products to firstname.lastname@example.com or New Products c/o Linux Journal, PO Box 980985, Houston, TX 77098. Submissions are edited for length and content.
James Gray is Products Editor for Linux Journal
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text:
Emilio Estefan brings the HEAT
New song Celebrate is for basketball fans
Emilio Estefan really wants to rev up Miami Heat fans.
The Grammy Award winning producer has partnered with the basket- ball team to create a new team song. You'll hear Celebrate just in time for Friday's home opener against the Orlando Magic, and it's guaranteed to get you moving with lyrics like "Feel the heat/C'mon now, the heat is on/It's hot in Miami/Stand up and make some noise."
There's also a Spanish part to the one-minute ditty -- "Miami esta caliente!'' It's a no-brainer why Estefan got involved. "We want to put Miami in the spotlight," he says.
"When people go to a game they want to enjoy themselves." The spotlight's bigger than ever with the Dream Team of James, Wade and Bosh. "We really do have something special in South Florida," Estefan continues. "We're making a difference when it comes to sports."
Celebrate, fronted by local rapper Punchy, is a musical hybrid. "It's a whole mix -- from hip- hop to R&B to Latino and Haitian music," Estefan explains. 'I think I capture the spirit of the city and it's a sound that will definitely generate a lot of excitement at the games." T
his is the second song used by the team -- the first Can You Feel The HEAT (Down In My Soul), was written by local pro- ducer, Derrick "Big D'' Baker in 1996.
On Our Radar
On Our Radar
- Hillary Clinton joins Marc Anthony on stage
- Scott Disick spotted with new ladyfriend in Miami Beach
- David Cassidy cited after car crash
- Young magician to appear at Arsht gala
- Phil Collins set to perform at charity gala
- Soledad O'Brien at 'I Am Latino in America' conference
- Shaq to host Barry University bash
- Cindy Crawford in town for new book
- Miami Marlins VIPs focus on wellness
- Alex Rodriguez buys pricey condo


text:
One of the significant coding changes with ICD-10-CM was including laterality within the code itself.
Welcome ICD-10!
Z-codes are used for the reason of the encounter instead of the V codes, they are found in Chapter 21: Factors influencing he
"Thanks for keeping us current and up to date. Your book has all of the information that we need. We look for your Renewal each year."
"We purchase the book every year so we can stay current with the changes."
"I really like your Behavioral Health MultiBook. It has been really helpful."


text:
• 1 year ago
no nothing....cant seem to find anywhere....found the gold & silver, but sold out!
• 1 year ago
I think they are air max 1 premium id, you just customize them as you wish... after long search for that pair I finally figured it out. Good luck girls!
• 1 year ago
Dee, I just got a response from Nike , it is air max 1 essential but it is out of stock... so the mystery is discovered :))))))
Suede and fringe are back in a major way. Step into the trend with a pair of booties.
Fabulous Shoes, Love Mi Style, Dreams Closet, Fall Style, Creative Finding, Shoes Boots Footwear
Put those old black pumps back in the closet. It's time for something new.
Black Pumps
Flats don't have to be boring – step it up with patterns and laces, loafers and pointed toes.
They might be flats, but they can give a style boost to any outfit.
Style Boost
Step into summer in a pair of strappy leather sandals.
Strappy Leather, Leather Sandals
For sandals, try a pair of sporty slides to give an outfit a relaxed edge.
Relaxing Edge, Sporty Sliding
Kick off summer with a pair of boat shoes, we love Sperry Top-Siders.
Boat Shoe
A floral pump for a modern but classically-feminine look.
Floral Pumps
Step out of the ordinary in neon pink strappy summer sandals.
Summer Sandals, Strappy Summer, Summer Dreams, Accessories Queen, Neon Pink, Pink Strappy, Shoes Porn
Go mad for plaid with Burberry shoes and accessories.
Burberry Shoes
Princess Shoes, Wedding Shoes, Wedding Ideas, Bling Heels, Rhinestone Shoes, Choo Jewels, Bridal Shoes, Heels Beautiful, Embellishments Sandals
Embellished sandals
Bling Heels
Once Wed and Madison James Wedding Ideas at Coqui Coqui by https://oncewed.com
Stunning dusty pink bridal shoes!
Gorgeous rhinestone shoes!
Jimmy Choo jewel wedding shoes
Princess shoes!
Pretty in a (pink) Jimmy Choo crossbody and Charlotte Olympia heels.
Charlotte Olympia, Olympia Heels, Jimmy Choo, Choo Crossbodi
Intimidated by a head-to-toe colorblock look? Try colorblock heels.
Photos Ideas, Illest Shoes, Shoes Games, Shoes Sho, Head To To Colorblock, Colorblock Heels, Poshier Pumps
Make it pop in pink Valentino Rockstud heels.
Fashion, Dreams Closet, Valentino, Dreams Shoes, Shops, High Heels, Kinda Shoes Boots, Heels Wedges, I D Wear
We have Giuseppe Zanotti to thank for these baby blues.


text:
How male and female brains diverge is a hotly debated topic, but the study of model organisms points to differences that cannot be ignored.
Speaking of Science
July 1, 2015|
July 2015's selection of notable quotes
July 1, 2015|
July 2015's selection of notable quotes
July 1, 2015|
A general guide to collecting and processing saliva
June 23, 2015|
An epigenetic variant of cytosine is stable in the genomes of living mice, suggesting a possible expansion of the DNA alphabet.
June 22, 2015|
A new study shows that kangaroos are predominantly left-handed.
June 18, 2015|
Genomic analysis suggests that the skeleton's closest living relatives are Native American after all.
June 12, 2015|
Scientists estimate the total amount of DNA in Earth's biosphere.
June 12, 2015|
The predatory toxins employed by animals separated by millions of years of evolution are virtually identical, a study shows.
June 11, 2015|
Austen Heinz, who founded Cambrian Genomics to custom print DNA and had grand ideas about designing organisms, has passed away at age 31.
June 11, 2015|
With the deletion of a single gene, female Japanese rice fish can produce sperm.
June 10, 2015|
Researchers in Africa observe chimpanzees stealing palm wine from villagers' cups and imbibing the beverage.


text:
From 1993 until midway through 2011, Newt Gingrich repeatedly and quite forcefully argued that the federal government ought to impose an ObamaCare-like individual mandate on Americans, requiring them to have health insurance or otherwise to demonstrate that they can pay their future healthcare bills. (Regular readers of The New American are well aware of this because this publication has covered the story extensively.) However, a recently unearthed recording of a 2009 conference call featuring the former Speaker of the House is getting quite a bit of attention in the blogosphere because it suggests to some that Gingrich explicitly endorsed the healthcare legislation then beginning its trek through the legislative process.
Following months of high-profile pressure by pro-life groups concerned over its ties to the abortion industry, Susan G. Komen for the Cure, one of the nation's largest breast cancer charities, announced that it was halting its long-time funding of Planned Parenthood, the nation's leading abortion provider. As reported by the New York Times, the long-anticipated move will cut funding to 19 of Planned Parenthood's 83 franchises, which have received money from Komen since 2005.
A coordinated effort to increase the United Nations' role in the fields of mental health and substance abuse is now underway, with experts, national governments, and global bureaucracies lobbying for the UN World Health Organization (WHO) to get more involved. Critics of the schemes, however, blasted the notion of a global mental-health regime.
The Obama administration announced January 20 that under its 2010 ObamaCare medical legislation employers will be compelled to cover birth control for women free of charge, including controversial contraceptive drugs which can induce abortion early in a woman's pregnancy. The administration rejected an appeal from religious organizations, led by the Catholic Church, for an exemption on insurance provided to employees of religious institutions such as hospitals, colleges, and charities.
Five percent of Americans are severely mentally ill, a new report from the federal government says, while about 20 percent suffer some sort of mental illness annually. The federal Substance Abuse and Mental Health Services Administration (SAMHSA) has again found that tens of millions of Americans are, in a word, crazy, and that women are crazier than men.
President Obama, along with the Democratic-led Senate and formerly Democratic-led House, touted the 2010 healthcare overhaul as a landmark law that would curb the rise in U.S. healthcare costs. However, according to a new report released last week by the Congressional Budget Office (CBO), reform programs akin to those endorsed by ObamaCare have neither abated healthcare costs nor salvaged any significant amount of government revenue.
A British-based pro-life leader said that a recent study by two influential organizations supposedly showing that "unsafe" abortions are on the rise is nothing more than pro-abortion propaganda. According to the Guttmacher Institute, Planned Parenthood's de facto research arm, and the UN's World Health Organization (WHO), from 2003 to 2008 the abortion rate fell ever-so-slightly from 29 to 28 per 1,000 women of child-bearing age.
Following months of activism by Tea Party and conservative groups in Wisconsin, Republican Gov. Scott Walker decided to officially reject millions of federal taxpayer dollars in the form of controversial ObamaCare grants that came with numerous "strings attached." Critics of the President's wildly unpopular health law greeted the news with relief.
The latest revelations from WikiLeaks confirm Monsanto's continuing efforts to influence governments worldwide to rule in its favor and punish those who won't.
A cable written in 2007 and released recently by WikiLeaks confirmed the company's important influence at the very highest levels of the U.S. government. Authored by Craig Stapleton, a friend and business partner of then-president George Bush, the cable outlined a response to resistance from various members of the European Union to adopting GM (genetically modified) crops. At issue specifically was France's move to ban Monsanto's GM corn variety:
The government of Greece is catching flack over its decision to add some questionable categories to its list of recognized disabilities. As reported by the Associated Press, disability groups in the country were especially outraged over the government's decision to add pedophiles to its list of those the state recognizes as disabled individuals. Among the other "disabled" categories added to the list were exhibitionists, kleptomaniacs, pyromaniacs, compulsive gamblers, fetishists, and sadomasochists.