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There is a great interest in understanding the genetic architecture of complex traits in natural populations. Genome-wide association studies (GWAS) are becoming routine in human, animal and plant genetics to understand the connection between naturally occurring genotypic and phenotypic variation. Coalescent simulations are commonly used in population genetics to simulate genotypes under different parameters and demographic models.
Here, we present phenosim, a software to add a phenotype to genotypes generated in time-efficient coalescent simulations. Both qualitative and quantitative phenotypes can be generated and it is possible to partition phenotypic variation between additive effects and epistatic interactions between causal variants. The output formats of phenosim are directly usable as input for different GWAS tools. The applicability of phenosim is shown by simulating a genome-wide association study in Arabidopsis thaliana.
By using the coalescent approach to generate genotypes and phenosim to add phenotypes, the data sets can be used to assess the influence of various factors such as demography, genetic architecture or selection on the statistical power of association methods to detect causal genetic variants under a wide variety of population genetic scenarios. phenosim is freely available from the authors' website http://evoplant.uni-hohenheim.de webcite
In recent years, genome-wide association studies (GWAS) became widely used to uncover the genetic basis of complex traits by comparing patterns of genetic and phenotypic variation [1-3]. The power of such studies depends on various factors that include the genetic architecture of the trait, the demographic history of the population, and variation in mutation and recombination rates [4]. In addition, the trait under investigation may be adaptive or (in case of a disease trait) can evolve under purifying selection, which both would result in a non-neutral pattern of genetic diversity in the genomic neighborhood of the causal mutation.
Coalescent simulations are widely used to simulate genotypes under complex demographies [5] with recent extensions to include recombination hotspots [6] and selection [7], or to simulate whole genomes [8]. Simulations are often used to test population genetic hypotheses by comparing simulated and observed data. However, such simulations produce only genotypes but not phenotypes, which are also required to test methods for detecting significant associations between genetic and phenotypic variation. Although some tools provide an option to map phenotypes onto simulated genotypes, they only allow the simulation of qualitative phenotypes [9] or require time-consuming forward-in-time simulations to create genotypes from complex demographic scenarios [10-13].
Here, we present phenosim, a tool written in Python [14] that was designed to add a phenotype to genotypes simulated by coalescent-based simulation tools. Simulated phenotypes may either be qualitative or quantitative traits with different effect sizes and may show epistatic interactions. Hence, the simulation of case/control studies as well as the search for quantitative trait nucleotides (QTNs) of a complex trait with a user-defined architecture is possible. By combining simulated genotypes and phenotypes, researchers can assess the influence of different factors on the power of new methods for association mapping, compare different methods or estimate an optimal sample size and number of markers for a given study design.
The general work flow of phenosim is shown in Figure 1. First, the user simulates genotypes with one of four different programs for coalescent simulations. In the current version, phenosim is able to read the output of the ms[5], msHOT[6], msms[7] and GENOME[8] programs. After the import of genotypes, a phenotype generated under a user-defined model is assigned to each genotype. The trait can either be qualitative or quantitative.
Figure 1. Work flow. Flowchart of the phenosim pipeline.
For qualitative traits, one- and two-locus models are supported. The user defines the model by setting the penetrance (probability of being affected) for all genotypes. In the two-locus model, this is done by a penetrance table for all possible allelic combinations among the two loci. Therefore, the user may define arbitrary interactions between all alleles of the loci. The case/control-status of all simulated individuals is then assigned according to the model. In many cases, disease states are caused by risk alleles segregating at low allele frequencies in the overall population. As such low frequency variants share a genealogy that may differ from high frequency variants and thus the linkage pattern around these variants may be different [15], the user can restrict causal mutations to a certain frequency range to obtain realistic risk loci. However, as this may result in a low number of cases in the final sample, users need to simulate larger populations and optionally enter a minimum number of cases to be sampled from the population. This procedure reflects the sampling procedure of many case/control studies.
For quantitative traits, multiple QTNs with additive effects or epistatic interactions between two QTNs are possible. By default locations of causal variants are selected randomly. Nevertheless, the user can determine the position of a QTN manually and/or restrict the selection to an allele frequency range. A phenotype is generated based on the formulas of [16], which we generalize for additive effects among multiple QTNs as follows. The trait value is calculated by adding a fixed variance proportion explained by the QTN to a random number drawn from a standard normal distribution with mean 0 and standard deviation 1, N(0, 1). We provide two different models, depending on the ploidy of the individuals. The effect of the j-th QTN is πj and the QTN has a derived allele frequency of fj. It should be noted that the sum of all QTN effects, ∑j πj, equals the heritability, h2, of the trait. If the individuals are haploid, the allelic state of the i-th individual at the j-th QTN is aij, where aij := 0 if the allele is ancestral and aij := 1 if it is derived. Then the phenotype Y of individual i is calculated as:
The phenotype of diploid individuals under an additive model without dominance is calculated as:
where Qij := 1 if the j-th QTN is homozygous derived, Qij := 0 if the QTN is heterozygous and Qij := -1 if the QTN is homozygous ancestral. Dominant effects at each QTN and additive effects between loci are also supported for diploids. In this case, equation (1) is used with aij := 0 for homozygous ancestral QTNs and aij := 1 for heterozygous and homozygous derived individuals.
If exactly two QTNs are selected, a positive, additive epistatic effect πE between these QTNs can be simulated. This epistasis is modeled as a fictive third QTN, whose allelic state aiE is 1, if the individual carries at least one derived allele at both basal QTNs. For users with a some Python scripting experience, other types of epistasis can easily be simulated by modifying the code of phenosim. To simulate a causal haplotype or allelic heterogeneity among two causal variants within a single gene, both QTNs may also be located on a common haploblock defined by the four-gamete test [17].
To our knowledge, quantiNemo[12] is the only software that currently supports the simulation of interactions between QTNs. However, quantiNemo utilizes time-consuming forward simulations, whereas phenosim allows to include epistasis between QTNs within a time-efficient coalescent framework.
After phenotypes have been generated, a predefined number of markers and/or individuals can be sub sampled from the total simulated population. The causal marker(s) can be optionally removed from the sample, since frequently the causal mutation itself is not genotyped in a genome-wide study. Finally, genotypes and phenotypes are written into different output file formats that can be directly used as input for commonly used association programs such as Blossoc/QBlossoc[16,18], EMMA/EMMAX[19,20], PLINK[21], QTDT/MERLIN[22,23] and TASSEL 3.0 [24]. A snapshot of phenosim is available as Additional File 1 whereas the most current version is maintained at http://evoplant.uni-hohenheim.de webcite
Additional file 1. phenosim v0.15. The archive includes the current version of phenosim as well as a documentation of its usage. For updated versions, please visit the authors' website http://evoplant.uni-hohenheim.de webcite.
Format: ZIP Size: 243KB Download file
Results and Discussion
To demonstrate the ability of phenosim to simulate data for GWAS, we utilized GENOME[8] and simulated populations Ne = 1000, with a population recombination parameter of ρ = 8 · 10-3 and 250,000 SNPs distributed over a 120 Mbp genome. These settings are comparable to data sets used for recent GWAS in A. thaliana [2,25,26]. phenosim was then used to generate phenotypes under three different models: (i) 2 QTNs, each with an effect of 0.05; (ii) 2 QTNs at random positions, each with an effect of 0.01, and epistatic interaction of πE = 0.08; and (iii) 2 QTNs, located on a common haploblock, each with an effect of 0.01 and epistatic interaction of πE = 0.08. In all three scenarios, the total proportion of variance explained by these QTNs and their interaction was identical (h2 = 0.1). Four hundred chromosomes were sub-sampled and the causal polymorphisms were removed from the data. EMMAX[20] was used to detect marker-trait associations and the causal locus for this hypothetical trait. In Figure 2 we show the proportion of significant markers that were found at a given distance from the causal locus. In the first model (only additive effects), less than 10% of the detected significant markers are located within a distance of 10 kbp to the causal locus. A larger sample size may increase the power to detect such small additive effects in genome-wide scans. Despite the smaller additive effect in model (ii), the number of significant markers within 10 kbp of the QTN was comparable to model (i). Additionally, there is an increased number of significant associations further than 10 kbp from the QTNs. These may represent false positive associations caused by epistasis, such as markers that are in strong linkage disequilibrium with the fictive epistatic marker [27]. The highest power was observed in the third model. QTNs on a common haploblock with epistatic effects create a strong joint QTL and therefore in more than 75% of simulations, a significant marker was located within a distance of 10 kbp to the causal locus. The results show that single marker association methods as EMMAX are able to detect QTNs with small additive effects and a strong positive epistatic interaction. However, in certain situations larger samples than simulated sizes are needed and some results may be confounded by false positives as discussed earlier [27].
Figure 2. Example. Proportion of significant marker-trait associations (Bonferroni adjusted significance threshold) found at different distances from the causal marker. For each QTN, the distance to the next significant association is shown. The bars on the left show the proportion of simulated data sets for which no significant association was found. The simulated models include: 'additive' - 2 QTNs randomly distributed with a variance proportion of 0.05 each; 'epi_rand' - 2 QTNs randomly distributed with a variance proportion of 0.01 each and 0.08 epistatic effect; 'epi_hapl' - 2 QTNs located on a common haploblock with a variance proportion of 0.01 each and 0.08 epistatic effect. Each model was simulated 1000 times.
On average, a single simulation ran 4 min with GENOME[8] and 2 min with phenosim on a single core of an Intel Xeon X5650 (2.66 GHz) Processor. To compare this running time with other software tools, we simulated two QTNs and 249,998 neutral loci in a population of 500 diploid individuals using quantiNemo[12]. In six minutes, quantiNemo generated ~120 generations. As the expected coalescent time for a sample is ~ 4Ne generations [28], this is by far not enough to get a realistic variation pattern comparable to what can be achieved by GENOME in the same time. Although forward simulations like quantiNemo allow more complex demographic, selection and trait scenarios, the combination of coalescent simulators and phenosim is much more suitable for generating multiple simulations of large sample sizes.
Demographic effects, genetic architecture, selection, and different mutation and recombination rates affect the ability to detect the genetic basis of complex traits in natural populations [4]. Such population genetic parameters can now be estimated from genome-wide marker sets prior to further analyses. Since GWAS are widely used in plant and animal genetics, there is a great interest in assessing the power of a particular study or method. Using coalescent simulations in conjunction with phenosim, one can investigate the statistical power and other characteristics of GWAS methods efficiently. Additionally, as different causal markers may contribute different effects to a trait, the essential sample size and number of markers to detect a certain pattern can be estimated.
Competing interests
The authors declare that they have no competing interests.
Availability and requirements
• Project name: phenosim
• Project home page: http://evoplant.uni-hohenheim.de webcite
• Operating system(s): Platform independent
• Programming language: Python
• Other requirements: Python 2.X
• License: no license required
• Any restrictions to use by non-academics: none
Authors' contributions
TG, IG and KJS conceived the project. TG and IG designed the software. TG wrote the code. IG analyzed the data. KJS supervised the project. All authors contributed to writing of the manuscript. All authors read and approved the final manuscript.
This work is supported by the BMBF under the German plant genomics program GABI (GABI-GENOBAR; 0315066F) and the Bioenergy 2021 Initiative (BioÖl, 0315429C); TG is funded by a Volkswagen Foundation Evolutionary Biology scholarship (I/84 225). We thank two anonymous reviewers for their comments and Sariel Hübner for testing the scripts and comments on the software features.
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Friends faked car crash to defraud insurance firm, Carlisle court told
Published at 16:50, Friday, 08 February 2013
Three friends who staged a fake car crash in a doomed attempt to defraud an insurance company have been given suspended jail terms.
Tony Proudfoot, 25, from Walton, near Brampton, dreamed up the scam with his two pals after deciding that he no longer liked his Renault Laguna car and that he wanted to have it written off, Carlisle Crown Court was told.
He executed the plan with Mark Patterson, 40, and 25-year-old Anthony Stirzaker, deliberately setting up a crash in London Road, Carlisle, involving his car and a van driven by Patterson.
Stirzaker, of Cumberland Street, Denton Holme, Carlisle, who was a front seat passenger in the car, later made a compensation claim for a whiplash injury he said he suffered, while Proudfoot claimed £1,900 for his written off Renault.
In court today, all three men admitted an offence of conspiring to defraud.
Gerard Rogerson, prosecuting, said police were called on July 3 last year by Patterson, who reported being involved in a crash on London Road.
He said he had driven into the rear of the Renault.
Both vehicles had minor damage and officers found Stirzaker lying on a patch of grass nearby, apparently with a minor injury.
Strirzaker later lodged a claim in the county court for an amount not exceeding £3,000, having visited a hospital A&E department with an apparent whiplash injury.
But police became suspicious and discovered through mobile phone records that there had been contact between Patterson, of South Street, Alloa, Clackmannanshire, and the others, though they all claimed not to know each other.
All "came clean" when confronted with that evidence, said Mr Rogerson.
Though none of the defendants had been previously involved in a similar scam, such bogus claims are now rife in the Manchester area, the court was told.
Mr Rogerson added: "This is the first case of this nature to be successfully prosecuted by Cumbria police.
"Nationally, there is a problem with these claims."
Elizabeth Muir, for Proudfoot, said he gave the £1,900 to somebody who lent him money to pay for transport after an accident.
"He's extremely ashamed of his actions," she said, adding that Proudfoot was a carer for his disabled mother.
He was adamant that he was not the one to suggest the scam, and pointed out that Stirzaker did not initially want to be involved.
Greg Hoare, for Stirzaker, said the defendant was a normally industrious young man but one who had a capacity for "stupid decisions".
Keith Thomas, for Patterson said the offence was a one-off for his client.
Judge Barbara Forrester told the three men: "I will make an example of you, and make it clear to other people who think of becoming involved in this type of matter that the courts will not tolerate them and will impose serious sentences."
As well as being given eight-month jail terms, suspended for 24 months, the men were also given 12 months supervision, and unpaid work in the community: 100 hours for Patterson, and 200 hours each for Proudfoot and Stirzaker.
All three men were told they were lucky not to have been facing more serious charges.
Published by http://www.newsandstar.co.uk
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Cetaphil Daily Facial Cleanser (Normal to Oily Skin)
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on 1/31/2014 4:19:00 AM
Age: 19-24
Skin: Combination, Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I have I say that I am impressed with the Cetaphil cleanser. I had always seen it at the store and never really gave it a second glance. After doing research, I found that a lot of people really like using Cetaphil as it is gentle on the skin and leaves it feeling clean and fresh. I have combo/oily skin so like I have said in other reviews it is very hard for me to find the right products for my skin. I'm always switching them up. I love this cleanser. I use this and then afterwards I put on the Boots Shine Control lotion. The combination of the two work wonders for my skin. This cleanser deep cleans without damaging your skin. It's a wonder product
on 1/27/2014 1:52:00 PM
Age: 19-24
Skin: Sensitive, Fair, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I have used Cetaphil Daily Facial Cleanser on and off for the past 10 years. It has helped me through my teenage breakouts and continued to calm my skin in my most recent years. I never forgive myself for venturing off into other products but this cleanser is so gentle and mild that I can always depend on it.
I do have a couple suggestions for others though. Even though buying in bulk sounds tempting, unless you go through these bad boys in three months I would not suggest buying it in bulk! I bought Cetaphil at BJS and it lasted me years but this nice translucent cleanser eventually became.. opaque and viscous. At one point I was sure it was expired! And it was breaking me out! Next, I also advise those who lean on the more sensitive skin side (as I do) to try out the gentle facial cleaner. This can irritate your skin especially in the winter.
Nonetheless, it is a staple in my house and life!
on 1/24/2014 3:23:00 PM
Age: 19-24
Skin: Acne-prone, Olive, Warm
Hair: Brunette, Straight, Medium
Eyes: Brown
I liked using this cleanser instead of the gentle cleanser. I used probably 2 big bottles of this product. I did some researched and discovered that it contained sodium laureth sulfate which causes breakouts. So I stopped using it. I have oily, acne prone, sensitive skin. I want to try the olay foming cleanser for sensitive skin to see if it works for me. Update: After trying to find a better cleanser and failed I had to run back to this cleanser. It is the only one that works for me. I have to say its my*HG* from now on. I am using Neutrogena makeup removing wipes prior to using the cleanser and I am loving the combo so far.
on 1/18/2014 1:59:00 AM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
This product is indespensable to me! I can not live with out it. It removes all my makeup from my face, it is strong but at the same time sensitive for my extrely delicate oily/dry skin. I've repurchased this bottle countless time. I recommend to my family and friends all the time.
on 1/15/2014 9:00:00 PM
Age: 30-35
Skin: Combination, Fair-Medium, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
I was going to wait a while before reviewing this, as I am recovering from a major breakout. I was compelled to write one because in the four days I have been using this I haven't had any new breakouts and I see my acne drying up. I love the scent, it is very clean and it does lather more than the regular cleanser. I've scaled back on my routine and used to bomb my face with salicylic acid. After reading a ton of advice tutorials on YouTube I decided to calm everything down. I wash with Cetaphil, tone with Dickinson's Witch Hazel and moisturize once a day with the Cetaphil lotion. I this routine is definitely working!
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DAVINES by Davines DEDE LEAVE IN MIST 8 OZ
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Just what I was hoping for... I have limp hair, and this definitely added texture that stays between shampoos.Published 2 months ago by Ava Wooton
Although I love the Davines line for hair, this one was a big deception. Just smells weird, feels weird.Published 4 months ago by fernelias
This leaves my hair moisturized and even a little bouncy. I definitely need another product to give my hair some texture so that it doesn't fall flat after a few hours but this... Read morePublished 5 months ago by Kristin
Love it, makes my hair soft, fuller, shiny and manageable. I used it with davines OI shampoo and OI oil - they work perfectly together. Read morePublished 7 months ago by rose lopez
I've nearly finished my first bottle of this product and I've just ordered another, this stuff is great. Read morePublished 7 months ago by Finch
I just received this product, and I'm already disappointed. It stinks like old lady perfume(even on your head!) and the bottle is very thin plastic which gives in when you squirt. Read morePublished 8 months ago by Sherry Ewy
Man, I love this stuff! My hair has so much more manageability and smoothness when I put this product in before blow-drying. Read morePublished 12 months ago by Amy Kline


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Manoush Zomorodi appears in the following:
Al Gore's Phone Dilemma
Wednesday, November 27, 2013
Al Gore has a more than a few fancy titles: Vice President, Nobel Laureate, environmentalist-in-chief, and Apple corporate board member. So we figured he'd be as good a person as any to ask about a seeming contradiction for technology lovers that has been nagging us here at New Tech City.
This Guy Brings Smartphones Back from the Dead
Wednesday, November 27, 2013
Meet Justin Wetherill, CEO of the smartphone repair chain uBreakiFix. He knows how to repair the iPhone whose screen you stupidly shattered when you dropped it on the sidewalk last night.
The Greene Space
The Magic Flute
Saturday, November 23, 2013
The genius of Mozart comes to The Greene Space! Join us for a special family presentation of Mozart's The Magic Flute, the fantastical fairy-tale opera about bird catchers, princes and enchanted instruments. Featuring the Amore Opera and hosted by WNYC's Manoush Zomorodi.
The Greene Space
The Magic Flute
Saturday, November 23, 2013
The genius of Mozart comes to The Greene Space! Join us for a special family presentation of Mozart's The Magic Flute, the fantastical fairy-tale opera about bird catchers, princes and enchanted instruments. Featuring the Amore Opera and hosted by WNYC's Manoush Zomorodi.
On-Demand Video: Tech + Today's Worker - Upgrading Your Skills in Every Phase of Life
Thursday, November 21, 2013
The importance of STEM (science, tech, engineering and math) education in schools has been getting a lot of attention lately. But it's not just kids who need to be savvy in those subjects to survive the global economy.
Flowchart: Should You Open Your Home WiFi?
Wednesday, November 20, 2013
To open your home wireless internet, or not, that is the question. And to help you decide whether or not to do away with that long string of garbled letters and symbols allegedly protecting your internet, we made you a flowchart.
WiFi on Wheels Rolls Into Public Housing
Wednesday, November 20, 2013
In areas of the city where New Yorkers don't have easy access to broadband, it can be difficult to find a job – or even a build a resume to get started. The New York City Housing Authority is trying to help some of its residents by rolling in WiFi on wheels.
The Greene Space
Tech + Today's Worker: Upgrading Your Skills in Every Phase of LIfe
Tuesday, November 19, 2013
Join New Tech City host Manoush Zomorodi for an evening of networking and insight on how continuing education in science, tech, engineering and math can help the next stage of your career.
1,021 Reasons Why This Family Built a Computer Just to Play Minecraft
Wednesday, November 13, 2013
Minecraft is the mega-popular video game that is all about building. It's sort of like Legos for the digital set. John Keefe, head of WNYC's data news team, channeled his family's Minecraft mania into a creative building project for the real-world: He and his daughter put together a computer from scratch so they could have a machine dedicated to the game.
The Rabbi Who Codes
Wednesday, November 13, 2013
Want to transform into a reporter for the Jewish Times Gazette circa 1909? There's an app for that.
A Civic Call for NYC Techies: Bring Digital Talent into Public School Classrooms
Monday, November 11, 2013
Tiny Estonia Beats the U.S. on E-Voting
Monday, November 04, 2013
The tiny Baltic nation of Estonia puts the United States to shame when it comes to electronic voting (not to mention marinated eel served cold and teaching little kids to code.)
A Juice Cleanse for Your Brain: 5 Steps to Relevance in Today's Workforce
Thursday, October 31, 2013
We used to classify ourselves as either artsy or analytical. Not only has the myth of left or right-brain dominance been debunked, limiting yourself to one or the other won't further a career these days.
Alone in the Dark: Susan Crawford and the Telecom Industry
Wednesday, October 30, 2013
A year after Sandy cut power to cellphone towers and flooded copper wire, land line telephones leaving thousands of people without service, what's changed? "Nothing," says Susan Crawford, author of Captive Audience: The Telecom Industry and Monopoly Power in the New Gilded Age.
Who Is Jeff Bezos? And What is Amazon?
Monday, October 28, 2013
30 Issues: Building NY's Tech Sector
Wednesday, October 16, 2013
It's Jobs Week in the Brian Lehrer Show's "30 Issues in 30 Days" election series. See the full 30 Issues schedule and archive here.
Jack Hidary, technology executive running for mayor as an independent, talks about what the next mayor could do to promote growth in the tech industry.
Then, Manoush Zomorodi, host and managing editor of WNYC's New Tech City, talks about how the tech sector fuels job creation.
When the FBI Knocks: A Techie's Moment of Truth
Wednesday, October 09, 2013
The recent revelation that companies like Google and Facebook routinely hand over data about users' digital communications to the National Security Agency has many Americans wondering whether everything they do online is being tracked by the government.
How Twitter Created Connections But Drove the Founders Apart
Friday, October 04, 2013
New Tech City host Manoush Zomorodi spoke to the New York Times technology columnist about why none of Twitter's original founders continue to work at the company and how a service built on connections ended up driving four friends apart.
Genetic Screening of Every Child
Wednesday, October 02, 2013
Scientists at the recently opened New York Genome Center eventually want to screen every child in New York State. But if doctors found that your child had a genetic disorder, would you want to know?
Technology Industry Races to Complete Online Healthcare Exchanges
Thursday, September 26, 2013
Manoush Zomorodi is the host and managing editor of WNYC's New Tech City. On this week's show, she reports on the tech firms rushing to build the exchanges before the October 1st deadline. She says that for a lot of technologists, they are more than a forum for shopping healthcare plans, they represent a huge business opportunity.


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Kathleen Goodwin | May 28, 2003 | Comments
No more hard sell! Four steps to make your newsletter create a dialogue with readers.
I made a presentation at last week's ClickZ E-Mail Strategies. I'll share part of it today for those who couldn't attend the event.
My talk focused on how newsletter publishers can avoid being just another interruption in a prospect's day by providing content the reader wants, needs, and seeks out. In doing so, not only do you let your prospects sell themselves, you'll also demonstrate you're prepared to participate in their lives in a meaningful way. For we newsletter publishers, this means changing our communications philosophy -- what we say and how we deliver information. The result is a dialogue of equals.
What does a dialogue of equals mean? It means going beyond the one-way communication most marketers have adopted in e-communications. It means tuning into behavioral differences, into how prospects react to the online marketing that flows into their lives and how it affects their overall online experience.
Most online marketers continue to use a one-way methodology. They throw something out there and wait for the sale. Prospects want to be sold right off the bat, but one-way communications just won't get the job done. Building trust and confidence a customer can rely on will.
I've shared many of my thoughts on this topic already, but to make the point in my presentation, I came up with a very good test I think all publishers should take from time to time. Take it yourself now. You might be surprised by the answers.
Are you holding a one-way e-conversation with your readers?
If you answered "no" to more than just a couple of these questions, admit it: You're a one-way marketer.
Understand you're not listening, not responding. You've not yet aligned yourself with your readers' online behavior, experiences, and expectations. You most likely still send campaigns rather than manage email conversations.
This is getting you nowhere fast, isn't it?
Change Your Ways
The quality of listen-and-respond communications can take an email dialogue far beyond selling, advertising, and marketing. With a very customer-focused approach to messaging, content, frequency, segmentation, and metrics, you can begin to create a dialogue of equals. You will truly understand where the prospect is in the buying process. This will demonstrate you're listening to readers, not just to the sound of clicks.
Another huge benefit of dialogues of equals is your newsletters will be less spam-like.
Ways to start a dialogue of equals with your readers:
In future columns, we'll explore segmentation more, including the importance of psychographics. Meantime, email your thoughts!
Meet Kathleen at ClickZ's Weblog Business Strategies in Boston, June 9-10.
Pro Rank Tracker is a cutting-edge ranking tracking tool for keeping you up-to-date with all the latest changes in the rankings of your websites and videos.
Kathleen Goodwin is the former CEO of IMN (formerly iMakeNews), specializing in customer acquisition and retention through permission-based e-newsletters. For nine years, she was vice president of marketing for Ziff-Davis' publishing division, where she oversaw the marketing of all print publications and their early online siblings. She also serves as an advisor to early-stage companies and has been responsible for several successful new-business launches.
October 21-22, 2015
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Spring 2016
US Consumer Device Preference Report
Traditionally desktops have shown to convert better than mobile devices however, 2015 might be a tipping point for mobile conversions! Download this report to find why mobile users are more important then ever.
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October 13, 2015
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November 12, 2015


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Hollywood keeps us on the edge of our seats with action movies, from James Bond to Jason Bourne.
About StumbleDNA StumbleDNA
anc65's Interests
Obsessed with Radiohead? Play Nirvana on repeat? Alternative rock music is awesome. Check out more.
Touchdown! Get the best of NCAA and NFL football while you wait for the next Superbowl.
From baby animals to wild creatures to exotic pets, discover cute pictures and more about animals.
We all need a little pampering sometimes. Explore makeup trends, hairstyles, skincare and more.
Think ordinary is boring? Explore the weird, the strange, the obscure, and the downright freaky.
Are you a bookworm? Do you dream of a Pulitzer? Explore the literature of your favorite authors.
Miss Saturday morning cartoons? Get your dose of cartoons - funny, political and more - here.
With order comes disorder. Learn about chaos theory, controlled chaos and the butterfly effect.
What's your style? From your shoes to your accessories, make a statement with your clothing.
Whether you like romantic comedies or black comedies, have a laugh by Stumbling through funny films.
Seen Elvis lately? Explore conspiracy theories about everything from the government to UFOs.
Get ideas for fun and easy DIY arts and crafts perfect for kids, holidays and more. Do it yourself!
From online dating to speed dating, we can all use some advice to calm those first date jitters.
Explore the art of design, from graphic design on the Web to interior design in the home.
We're all a little bit addicted...to Facebook, that is. Get the latest company and product news.
Despite the occasional feud, family is forever. Explore modern family relationships and dynamics.
Think you're the next fashion star? Explore the trends and designers heating up the runway shows.
Discover your cultured side! You don't need to go to a museum or theater to explore the fine arts.
Take care of yourself! Learn about physical and mental health, fitness, nutrition and more.


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This is a wonderful little earbud. Small, yet powerful.
Pros: Mostly Neutral Sound Signature, Different Looks, Small Size, Nice Unique Triangle Cable
Cons: Fit Can Be an Issue for Some, Bit Bright at Times
Pros: Mostly Neutral Sound Signature, Different Looks, Small Size, Nice Unique Triangle Cable
Cons: Fit Can Be an Issue for Some, Bit Bright at Times
Pros: Fantastically Controlled Sound Signature, Great Build, Wonderful Cable,
Cons: Simple Design
Pros: very impressive sound quality, premium cable, relatively good fitment
Cons: high impedance, need for a balanced cable termination, a bit pricey
Pros: bass not muddy or bloated but relatively solid, fit, comfort, soundstage, good bass extension for earbuds
Cons: mids too warm, can't compete with similarly priced In-Ears, no chin slider, no traveling pouch
" Before I start my review, I would like to Thank VE and @zhibli06 for providing me with a review sample of VE ZEN (and MONK) in exchange for my honest opinion. Manufacturer website: http://eng.52ve.cn/ Just like a deja vu from a few weeks ago when I mentioned in one of my reviews that I can't believe I'm writing about CIEM (I usually test and review only in-ears..." --twister6
"Just like the Koss KSC75 and the Fiio X1, the E100 Earbell from Baldoor (and Mrice) represents a phenomenal value. This little $14 wonder has done two things for me: 1. It has renewed my faith in earbuds and 2. Has proven yet again, that top tier sound can be had for bottom tier prices - you just have to be willing to look! If you're interested in a new super-cheap piece of kit for your commute..." --JoeDoe
" These are quite common in retail stores in my city (Toronto) and cost around $15-$20 CAD. I've been using them for years, because they are inexpensive, sound decent and are portable. They don't sound too distorted at high levels. I never had mines break, never had audio jack or audio cut out problems, but then again it really depends on the user, because I am very careful with my..." --Carbine
"I'll be short : I was very disappointed when I listened to the PAA1-Pro the first time. I found bloated bass, harsh highs and a typical mainstream V-shaped sound signature. So, I began a hundred hour burn-in and retry it... Nothing changed a lot. Maybe the highs became less harsh but still not what I would call pleasant to my ears. I put them away a time and come back to them after two weeks...." --tinara
" *edit as of 15th feb 2015* : after so many hours passed with BE3, I decided to grab some weeks ago a pair of Edifier H180, and I found it even better than the Blox one. BE3 has more a V sound signature especially with more highs but less bass. H180 is the contrary, even thought it has also a V sounding signature, it brights in bass domain but highs sounds more true because has much more..." --subwoof3r
"Dont let these tiny guys disappoint you by looks. Plug them in and you wont believe your ears. These are that good, It sounds like large over ear headphones. I have owned many earbuds like Sennheiser MX-170, MX-270, MX-580, Tingo TG-38s and for IEMS I have owned TTPOD T1e, JVC HA-FXT90, Sony XB90ex and Yamaha EPH-100 and believe me these tiny earbuds blow all of them out of the water. You..." --sharonbava
" I love this product. It is so comfortable and easy to use. I recommend this for everyone. " --karyz123
" These are by far the best headphones I have ever used. I have bought them for years but they have sadly been discontinued in favor of their new and horrible version, the e9lp. " --hellomisa
"i am using this for a year and this earbuds is great, a bit expensive. " --crazyj971
" Blox ANV3 Quick Review (Thread here, http://www.head-fi.org/t/656806/blox-anv3-quick-review ) Thanks to SwimSonny for the loan. Brief: Blox proves it owns bud sound quality. Price: US$63 in theory Specification: Driver: Dynamic 15 mm, Frequency Response : 20Hz - 18KHz, Impedance:..." --mark2410


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What a lousy experience! Bad service, condescending staff, mediocre and overpriced food. It started with the host who we asked for help with the muni meter who said I recommend valet and when we asked her for change for a $5 and she said get it from the bartender. Then snooty waiter who tried to upsell us on the fixed menus and lots of other things. He took the order and never came back. Dirty plates sat until entree... view moreLike this review?Yes  (1)|Flag AbuseProvided by Citysearch
Mr Chow
Today:6:00 pm - 12:00 am
Tomorrow:6:00 pm - 12:00 am
2201 Collins Ave,
Miami Beach, FL 33139
(305) 695-1695
Book a Table
Business Details
in Business
- Hours:
Regular Hours
- Payment method:
- mastercard, amex, visa, diners club
- Location:
- W Hotel
- Neighborhood:
- City Center
MR CHOW- Miami
- Other Link:
- Categories:
- Restaurants, Chinese Restaurants, Fine Dining Restaurants
Mr. Chow was a fun place to go, but needs to start taking it's guest's needs and standards a bit more seriously. The staff acted as though it was our privilege to be there as a paying guest. It took our table of 7 almost an hour to get a food menu. First a server arrived who only took cocktail orders (which he proceeded to screw up and not apologize for). The waiter was basically inaudible and spent too long expl... view moreLike this review?Yes  (1)|Flag AbuseProvided by Citysearch


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ReviewGist App
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ReviewGist helps you find the best products to buy by making sense of online reviews. We are currently aggregating 370,032 reviews covering over 29,175 products. See what the press says about ReviewGist here.


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nostrum oil & gas plc
(NOG:London Stock Exchange)
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Change Today +5.50 / 1.05%
Volume 24.2K
NOG On Other Exchanges
As of 4:57 AM 10/9/15 All times are local (Market data is delayed by at least 15 minutes).
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Executive Chairman and Member of Nomination & Governance Committee
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Career Development
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Learn how to understand and communicate your professional value and get what you want in a salary negotiation.
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An American Tail: Fievel Goes WestAn American Tail: Fievel Goes West (1991) Feature Length Theatrical Animated Film
This page has been viewed 47 times this month, and 4328 times total.
- Amblin Entertainment, Universal Pictures, Amblimation
- Featuring: Fievel Mousekewitz, Wylie Burp, Mama Mousekewitz, Tanya Mousekewitz, Papa Mousekewitz, Tiger, Miss Kitty, Cat R. Waul, Chula, French Cat, NY and Country Mice, One-Eye Cat.
- Directed By Phil Nibbelink, Simon Wells.
- Produced By Steven Spielberg, Robert Watts, Steve Hickner, Kathleen Kennedy, David Kirschner, Frank Marshall.
- Animated By Bibo Bergeron, Eric Bouillette, David Bowers, Luc Chamberland, Denis Couchon, Nadja Cozic, Ceu D'Elia, Shane Doyle, Raul Garcia, Rodolphe Guenoden, Daniel Jeannette, Piet Kroon; more Animators ...
- Written By Flint Dille, Charles Swenson, David Kirschner.
- Originally Released in 1991.
- Color
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|Reviews for To Make Love A Prisoner of The Mundane
| Guest chapter 1 . 8/23
I love it!
| xoKrystalMox chapter 1 . 1/31
I've read this a few times and well, it gets me laughing all the time especially with Clint's part. Gosh, Clint, he just doesn't know when to stop, does he? I just adore this Thank you for sharing
| thingsthatmakeme chapter 1 . 10/25/2014
Perfect little one shot! I absolutely love it :)
| PSML chapter 1 . 2/8/2014
Cutest thing I've ever read!
| Fi Suki Saki chapter 1 . 6/11/2013
It's GREAT!
This is Awesome!
Fun and Adorable!
How Tony need Steve, and how Steve taking cafe of Tony was Increadible Sweet!
| RoseLaurel chapter 1 . 3/12/2013
Awww... adorable _ Might have been nicer as slightly longer chapters, but I loved reading it nonetheless :D
| HetaPastaH3ro chapter 1 . 2/28/2013
They let that same mess sit in the lab for two months?
| sarai-sama chapter 1 . 11/5/2012
Wow! That was awesome! Simple, short and yet eloquent! Beautiful, I loved it. Thank you for bestowing your creation upon the world. You have ranked higher than sleep, which is what I should be doing, but your creation is oh so worth it.
| yaoifangirl42 chapter 1 . 10/15/2012
AAWWWWWWWWWWWWWWWW! That was the cutest. I love stony and gosh, you really wrote this very well. This review sucks, but only because you have overwhelmed my mind with stony fluffiness and i can't even think straight and i have to keep erasing and rewriting because i keep spelling everything wrong.
*deep breath* okay, i think i'm good now. But you did an amazing job, i like how you captured the characters and they're not totally ooc, but just the right amount to account for the fact that love changes a person. It was awesome and I'm glad i had a chance to read it. Keep up the amazing work!
| nypd55chick04 chapter 1 . 8/3/2012
"if Phil and Clint had a baby, it would be Darcy. " OMG that is the best line EVER!
| Professor03 chapter 1 . 7/20/2012
This is so sweet! I love your writing style!
| Guest chapter 1 . 7/7/2012
it's so sweet i feel like i am about to explode with sheer pleasure
| Guest chapter 1 . 7/2/2012
That was cute, a few mistakes with similar sounding words here and there but nonetheless it was great, some good laughs there with Thor and the rest.
| Bella chapter 1 . 6/22/2012
Great job. You kept everyone in character, their reactions to and times with Tony were very real/natural to the characters. This is probably one of the most in-character Tony/Steve's I've read. The scenes with each different character were great and super funny, and I'm psyched you included Darcy because I'm convinced she and Tony would be BFFs.
| Firewolf27 chapter 1 . 6/19/2012
I just- I can't explain the love for this i have! Bravo!


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text: I'm looking to do something simple such as drilling down on a particular UITableViewCell, which brings up a detail view controller. Within there, the user has the capability to change the attribute for the model underneath the cell. For instance, If I'm displaying a list of quotes, and a user clicks on a quote and favorites it in the child controller, I want to be able to display an image which was hidden now that it's favorited placed, a star perhaps. What's the easiest way to update one particular UITableViewCell in such as fashion? Is it best to reference the selected UITableViewCell into the child controller and couple them in such a fashion? How is something like this done?


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A collection containing the following works:The White Bull: A Satirical Romance,Zadig; or Fate,The Sage and the Atheist,The Princess of Babylon,The Man of Forty Crowns,The Huron; or, Pupil of Nature,Micromegas,The Study of Nature
affairs by an ever-manifesting interposing Providence, may be just as easily refuted as proved by history and experience. In Memnon is shown, in an admirable manner, how the multitude are enamoured of their prudence, and laugh at nature and its feelings. In the Ingenu, the witty man yields himself up wholly to his humor and to accident, and brings forth a rich abundance of wit and flashes of genius with respect to the most various subjects."
"Voltaire had the genius of criticism," says Lamartine,[11] "that power of raillery which withers all it overthrows. He had made human nature laugh at itself, had felled it low in order to raise it, had laid bare before it all errors, prejudices, iniquities, and crimes of ignorance; he had urged it to rebellion against consecrated ideas, not by the ideal but by sheer contempt. Destiny gave him eighty years of existence, that he might slowly decompose the decayed age; he had the time to combat against time, and when he fell he was the conqueror.
When the economic downturn ends Matty Cruzs co... Read more
Cara Devon has always suffered curiosity and im... Read more
A telekinetic teenager. A telepathic child. A p... Read more
A century after an apocalyptic war reduces all... Read more
Fall in love with the Kensington siblings in th... Read more
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It seems only the
casbah we can use in scala, but I hope there is a orm-like library for scala, like
morphia for java, or something else.
Is there any? I don't want to use
morphia in scala because I have to convert java collections to scala
I've tried some of them, but still not find a proper one. Some are hard for scala newbies to get started.
Finally, I chose mongo-scala-driver, its awesome. Thanks to everybody.


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Search for "Cocoa Beach Public Library" or visit facebook.com/cocoabeachlibrary and LIKE us for updates in your Facebook News Feed about upcoming programs and events, new releases, and more news from your favorite public library!
October Art and Artists:
Main Library: Strawbridge Art League
Community Room: Clyde Mann - Paintings
Display Case: Robert Graves - Woodcarvings
Fine Art Photography Classes taught by Mick West
Mondays, September 28-October 26 from 2-4pm, in the Jane von Thron Room
Learn the fundamentals of composing a photograph for maximum impact and explore the benefits of Picasa, a free, user-friendly imaging program. This class is about art and seeing, not how to operate your camera. Prerequisites: a point-and-shoot digital camera, the ability to transfer digital images to a flash drive, and a desire to take great photos and have fun. Cost is $20 for the 4-class series. Please pre-register; enrollment is limited. View Micks work at here. (No class on October 5.)
Free Friday Movies: Passport Pictures
Fridays, October 2-30 at 3pm
Experience exotic locations in these movies that take us beyond our shores. Popcorn and refreshments will be served.
October 2: Le Week-End, rated R, 93 minutes
October 9: The Brothers Bloom, rated PG-13, 114 minutes
October 16: No film
October 23: Woman In Gold, rated PG-13, 109 minutes
October 30: The Second Best Exotic Marigold Hotel, rated PG, 122 minutes
Handmade Greeting Cards with Ree Nathan
Wednesday, October 7 from 9:30-11:30am, in the Captains Room
Paper artist Ree Nathan will help you give your greetings unique style. Create three elegant greeting cards with beautiful cardstocks and papers, stylish stamps, ribbons, and embellishments, and using special equipment to give your cards shapes and embossed textures. Cost is $10; all supplies provided. Register with Ree in advance by emailing firstname.lastname@example.com or calling 321-961-2350. Enrollment is limited.
Professional Medium John Rogers
Wednesday, October 7 at 6pm
Professional medium and author John Rogers will discuss mediumship and give brief individual readings as time allows.
Florida Surf Museum presents a Free Surf Movie: Beyond the Surface
Friday, October 9, doors open at 7pm, movie at 7:30pm
The Florida Surf Museum sponsors a yearly celebration of women surfers in the Sunshine State featuring surfing socials, stand-up paddleboard tours, meals, merrymaking, and more. The 6th Annual Women of the Waves Celebration will kick off with Beyond the Surface, a film about Indias first female surfer, Ishita Malaviya. On their journey through southern India, women surfers and the people they meet share experiences and stories related to surfing, yoga, and ecological awareness, resulting in mutual feelings of hope, a fuel for change, and the empowerment of women. Free organic popcorn and sodas provided courtesy of Sunseed Co-op.
Smartphones and Tablets 101
Tuesday, October 13 at 10:30am for Apple devices and 2pm for Android devices
Still trying to figure out your smartphone or tablet? Learn the basics about how your device works, what it can do for you, and how to get the most out of these helpful machines. It would be beneficial to come to class prepared with your account names and passwords for your App Store, Google Play, and/or email accounts so that you can participate in demonstrations. Taught by Barb Barrett, a former teacher with a lifelong interest in technology. Please register in advance for the class that addresses your device; enrollment is limited. Cost is $5.
Caregiving Classes by Hospice of St. Francis
Weds. from 10-11:30am and Fri. from 2-3:30pm, Oct. 14-30, in the Jane von Thron Room
Current and future caregivers use these free classes to find great information and local resources to help with this important yet stressful journey. The class series keeps caregivers informed and healthy years prior to the need for hospice. Please register in advance with Barbara Borman, RN, at 321-269-4240 ext. 3452 or firstname.lastname@example.com.
Spiritual Wisdom on Life After Death: Open Discussion
Wednesdays, October 14 & 28 at 6pm, in the Captains Room
Is soul eternal? What happens when we die? Why reincarnation? Gain insights on these and other questions for a deeper understanding of life after death and coping with loss of loved ones. All are welcome to attend this discussion using the Spiritual Wisdom on Life After Death booklet by Harold Klemp (provided free of charge). Presented by local members of Eckankar.
Health for Life: New Solutions to Eliminate Pain
Friday, October 16 at 10am, in the Jane von Thron Room
Dr. Sylvie Morin, DOM, will inform you about natural and holistic methods to manage and eliminate pain. Please register in advance for this free lecture.
20th Annual International Sea-Bean Symposium & Beachcombers' Festival
Friday & Saturday, October 16 (10am-6pm) & 17 (9am-9pm)
Noted scientists, authors, and sea-bean enthusiasts will be present for this 2-day event celebrating driftology and the treasures it yields. Displays, presentations, beach walks, contests, and discussions will make this an interesting weekend. Dr. Blair Witherington will give the Keynote Speech about Zen and the Art of Drifting at 7:45pm Saturday evening. More info about the schedule and events is available at seabean.com.
iPhone Photography
Tuesday, October 20 at 6pm, in the Jane von Thron Room
Want to do better at capturing memories as they happen? You can take better-looking photos with your iPhone to share on Facebook, send to your friends, or just spread your artistic wings. Ruth Bleakley will show you photography basics with your iPhone, like how to set up nice looking shots, compensate for bad lighting, and do some basic editing. All versions of the iPhone are welcome, though the latest software update (iOS8) has the most photographic capability. Cost is $5. Please register in advance; enrollment is limited.
Savvy Travel With Your SmartPhone
Wednesday, October 21 at 2pm, in the Jane von Thron Room
You can use your smartphone to find the best flights, keep track of your travel schedule, simplify your packing list, map your route, call your car, ease you to sleep, and more. Find the apps and methods to increase your travel know-how by using technology you can hold in your hand. This class is taught by Barb Barrett, a former teacher with a lifelong interest in technology. Please register in advance; enrollment is limited. Cost is $5.
Watercolor Classes with Award-Winning Artist Helen Wheatley
Thursdays, October 22 November 19, 10am-12:30pm
Watercolor artist Helen Wheatley creates exquisite paintings rich in color and content. Her work Faces at the Oasis won best of show at the Central Brevard Art Associations annual show in March 2007. Shell share her skills with you in these classes suitable for beginning and intermediate students. Cost is $50 for the 5-week session. Enrollment is limited: Please register in advance at the sign up table and pick up a materials list.
Western Humanities: Greek & Roman Sculpture
Thursdays, October 22 November 12 from 3:30-5:30pm, in the Jane von Thron Room
Learn how the ancients represented the human experience and how their arts compare and contrast to our modern cultural expression. Taught by former Rollins College instructor George V. Richards. Cost is $20 for the series. Please pre-register; enrollment is limited.
Food For Life: Nutrition & Cooking for Diabetes
Saturdays, October 24-November 14 from 1-3pm
Diabetes is a major public health issue that is unfortunately becoming more and more common. Uncontrolled, it can lead to complications from head to toe, but different nutritional approaches can greatly benefit those living with the condition. Food For Life instructor Susie Fricker will teach you to implement a nutritional plan and cooking ideas filled with vegetables, fruits, whole grains, and legumes to help with diabetes prevention and treatment. Cost for the class series is $40. Please register in advance with Susie at email@example.com.
Music on a Sunday Afternoon: Kasondra Rose & the Sleepless
Sunday, October 25 at 2pm
Were very happy to kick off another Music on a Sunday Afternoon season with Kasondra Rose and The Sleepless. They will knock your socks off with their swingin', funky, soulful style, playing original music and cover songs with a spin. Greg grounds the group with his thick bass lines, John lays down a sick groove on the drums, and Elliot (son of former Cocoa Beach Library director Ray Dickinson) adds flavor with every lick. Together, their unique arrangements and playful energy will leave the crowd buzzing!
Mondays, 11am, Overeaters Anonymous. This group meets each Monday in the Jane von Thron Room. For further information contact Tom M. at 321-784-8092.
Mondays at 4:30pm, Healthy Weight Loss. Accountability and Support. Get the right tools, guidance, and support to help you lose weight in a healthy way and learn how to keep it off. For more info contact Health Coach Catrell Cooney at 321-848-8823.
Tuesdays, 4pm, Al-Anon Family Group. Friends and family of alcoholics meet every Tuesday in the Captain's Room.
2nd Tuesday, 1pm, Beach Readers Book Club. The next meeting takes place October 13 in the Captain's Room and the selection will be In the Garden of Beasts by Erik Larson.
3rd Tuesday, 2pm, PlayReaders Group. All attendees are provided with a copy of the play and are encouraged to participate. The next meeting takes place on October 20 in the Jane von Thron Room. Contact Shirley Finke for details at 321-613-2667.
Wednesdays, 9am-4pm by appointment, Health Insurance Enrollment. Get help signing up for insurance through the ACA Healthcare Marketplace. For more info or to set up an appointment, contact Navigator Teri Rice at 321-544-1153 or email email@example.com.
Wednesdays, 2-4pm, Socrates Café. Engage in stimulating conversation on a variety of philosophical and existential topics. No reading or preparation required. Topic for October 7: Do words matter?
2nd Wednesday, 11:30am, We'll Read Book Club. Newcomers are welcome to attend. The next meeting takes place October 14 in the Captain's Room and the selection will be The Children Act by Ian McEwan. For more info contact Mary Lambert at 799-9286.
Thursdays, 1-4pm, The Watercolor Group. This social, non-instructive painting group is open to anyone with an interest in watercolors. Bring your materials and paint with fellow artists. For further information, contact Cathy Brion at 321-258-2011 or Jo Lincoln at 321-868-0163.
Fridays, 10am-1pm, Master Gardening Clinic. Master Gardeners answer questions about plants, pests, diseases, etc, in this open house held each Friday in the Captain's Room. Contact Marion Anderson for details at 321-784-1874.
Fridays, 11am-3pm and other times by appointment, SHINE Individual Counseling. Trained SHINE (Serving Health Insurance Needs of Elders) counselors assist seniors and the disabled with their Medicare and Medicaid questions in Study Room 4. SHINE one-on-one counseling is free, unbiased, and confidential. For more info or to schedule a counseling session call 321-323-9418 or email email@example.com.
4th Friday, 10am-12pm, Open House with Commissioner Jim Barfield in the Captains Room. Citizens of District 2 can address issues of concern with their County Commissioner. No Open House in November or December.
Moving to Mondays on 9/21, 10:30am or 12pm: Senior Fitness for Fall Prevention. Exercise physiologist Kent Dobbins specializes in biomechanics and exercises designed for people over 60. This hour-long class increases stamina, strength, energy, balance, and helps reduce risk of falls. Movements are low-impact and can be adapted for sitting or standing participants. FREE; all equipment provided.
Tuesdays beginning 9/15, 2-3:15pm. Hatha Yoga with Emily Hain. This fun, non-competitive class is appropriate for beginners and those experienced with a gentle, mindful practice. Students must bring a yoga mat and be able to get up and down from the floor. Cost is $5 per session.
StoryTime Tuesdays, beginning September 1
10:15am, Toddler Time (ages 5 and under)
Annual Harvest Festival
Sunday, October 4 at 2pm
Enjoy refreshments, popcorn, games, and crafts. Win Library Bucks. Fun for the entire family! (Please bring a canned good for the Girl Scout Food Drive and individually wrapped cookies, brownies or cupcakes for a cupcake walk.) Generous support for this program was provided in part by the Brevard Library Foundation.
Read to a Space Coast Therapy Dog
Sunday, October 11 at 1:15pm
The Space Coast Therapy Dogs are coming to the Cocoa Beach Library - cuddle up with a furry friend to read a favorite story. Please sign up in advance with the Youth Dept.
LEGO Club
Wednesdays, October 14 & 28 at 4pm
Join in for building challenges, individual and team projects, contests and themed events. Bring your own bricks or dig into our collection to create unique designs. Please sign up in advance with the Youth Department.
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Undergraduate Mentoring in Environmental Biology (UMEB) Active Awards
This page shows the geographical distribution of active American Recovery and Reinvestment Act of 2009 (ARRA) awards for NSF. You can also
view the awards in a list.
Click on a name in the table below to view active
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Parthenon Sao Bernardo Do Campo Saint Moritz
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Overnight in the city
... how we don't discuss where we are going, we just go from the bus to the m�tro to the hotel and just enjoying being together in the city...
Life is good!
http://www.metro.sp.gov.br/pdf/mapa-da- rede-metro.pdf
... me anyway.
- Thanks be to God for kabobs, theological reflections, the Brazilian equivalent of Katy Perry, and conversations in the strangest mixture of Portuguese and English imaginable with an incredible friend.
- Thanks be to God for the traditional pause of lunchtime: time to stop, time to eat, time to laugh with friends, time to enjoy life.
- Thanks be to God for contextualization. With the modular class system, making connections about ...
Academic Adventures - Liturgy
... before I started. However, from the point of view year two, those adjectives are fairly accurate. This semester abroad has been particularly filled with adventures of the academic, cultural, culinary, and touristic kind! As I have neglected the academic exploits, let me give them a bit of attention...
Liturgy Class
I would say that the class is divided into three parts: biblical-historical foundations of Christian liturgy, survey ...
A bit about grace
... frame for the marathon correction process. After an hour, conjugations and definitions and verb tenses sounded like instruments of torture rather than tools for communication. In my frustration familiar thoughts reappeared, Why can I not do this? Why do I always need so much help…It was at this point that the girls suggested a trip to snack bar. At the snack bar, Marcia supplied tea, prayer, and jokes. ...
The Mess and the Joy of Change
... cada vez mais. Se voc� n�o encontrar raz�es para ser livre, invente-as. Seja criativo. Voc� certamente conhecera coisas melhores e coisas piores do que j� conhecidas, mas n�o � isso o que importa. O mais importante � a mudan�a, o movimento, o dinamismo, a energia. S� que esta morto n�o muda!
Repito por pura alegria de viver: a salva��o e pelo risco, sem o qual a vida n�o vale a pena!!!!
Now for English. Please be advised this ...


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wife gets fucked again she likes it so much that she fucks my neighbours all the time while i am filming it with a hardon
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This design is really cute I love the idea of the designer love it, Cats were really close to my heart. – Weathershield Reviews
The Happy Adventurer II
Meow..this is the time for a kitten to take the adventures. Collect this happy kitten art on Tees, phone cases and prints today.
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I'm hoping someone here might know - I'm getting laid off for January and February, and our landlords suggested seeing if we could get help with our gas because we live in a very large, all gas house that is extremely expensive to heat in the winter. I've already looked into all the programs and income guidelines, and since it goes off your pay for either the last 3 months or last 12 months, we're above the limit. So my question is, has anyone gotten this kind of assistance before and know if the application takes into consideration losing a job or the end of an income? We'd definitely qualify if they only consider my husbands income - which is the only one we'll have for the winter.
I'm calling the gas company tomorrow to ask if there's anything we'd qualify for anything, but I figured I'd ask here anyway.
****We live in Ohio.


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(Previously known as Pixel Miners) Excavate is a heavily inspired, side-scrolling sandbox game from the development group Blue Cake.
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Drawn up by BlueLogic, this is a concept for a zombie enemy.


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After a number of successful seasons culminating in the Colts tour to Annecy in 2013 we have no U18 team this season. It will probably be another season or two before we are able to field a team at this age-group again.
In the meantime, we still welcome those who are aged 16 and 17. Some older boys may be strong enough and wish to play senior rugby. This can be accommodated but we have to apply to the SRU to get their approval first. A couple of boys have applied this season and have been successful.
Any who are particularly keen may wish to assist with coaching the younger players. We are always looking for helpers with our Mini teams. The man to approach is our Coach Coordinator, Alan Deas, who will be delighted to give advice and make any introductions.


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Interactive Designer
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Those hints of sunshine and warmth this month mean only one thing - Barbecue season may just be around the corner!
Planning a Eurovision party this weekend? Patrick Hanlon rounds up 20 great recipes to serve at your celebration...
Launching Eye Q's exam Study Pack, Patrick Hanlon gets the low down on fish oil supplements and the benefits of eating fish from Emma Buckley.
Patrick Hanlon visits Dublin's Wagamama restaurant to learn all about the skilled art and history of creating ramen.
Enjoying the BBQ season without meat and certain animal products has never looked or sounded so delicious. Patrick Hanlon profiles some free from recipes...
Arnotts are set to launch their inaugural 'Arnotts Cook Month' in association with Miele, Kenwood and Expert Electrical.
Summer is just around the corner and hopefully the sunshine too!
RTÉ Radio 1 programme Countrywide has enlisted the help of Grow it Yourself Ireland and the Sandymount Dublin Group to cultivate Gerry Ryan's former allotment.
Bord Bia has announced Wilde's at the Lodge, Lisloughrey Lodge Hotel, as the Just Ask Restaurant of the Month for May.


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Dear Theo: The Autobiography of Vincent Van Gogh
Houghton Mifflin, 1937 - Artists - 572 pages
From inside the book
2 pages matching Claude Monet in this book
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He was a wonderful writer. - Goodreads
I read to gain more insight on him and his paintings. - Goodreads
Van Gogh was a beautiful writer. - Goodreads
Nevermind that he was also writing - Goodreads
Review: Dear TheoUser Review - Dorcas - Goodreads
This book is in serious need of a re-read. I read this when I was about thirteen, and aspiring to be an amazing artist. Vincent Van Gogh fascinated me. I never really loved his art (shhh) but the mad ... Read full review
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Review: Dear TheoUser Review - Laurel Hicks - Goodreads
I had to read these letters slowly, because each brought a flood of color, art, and human emotions to my mind. Vincent was very well read, and he wrote almost as beautifully as he painted Read full review
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Common terms and phrases
able afraid Antwerp Arles artists beautiful become begin believe better blue Borinage canvases certainly Claude Monet colour Corot dark Delacroix difficult diggers drawing Drenthe dunes especially Eugene Delacroix everything expenses express Father feel figure francs Frank Holl garden Gauguin give glad green grey guilders Hague hard head heart heath Hoogeveen hope impressionism impressionists keep kind landscape less light live look Mauve melancholy Millet models month morning Mother nature never night once one's painted studies painters Paris peasant perhaps portrait Rappard Rembrandt Scheveningen seems seen sketch sometimes speak splendid stand stay talk Tarascon tell Tersteeg Theo things thought told tone trees TRINQUETAILLE understand walk water-colours week Weissenbruch winter wish woman women yellow Yesterday Zundert Zweeloo


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This smart-looking hotel has a handful of pools, plus a beach on the doorstep.
This hotel is surrounded by acres of greenery, dotted with whitewashed buildings. Inside things are just as smart, with a minimalist vibe. In the lobby squared-off slate grey armchairs nuzzle floor-to-ceiling glass windows. The bedrooms also looks the part, dressed in candy stripes and splashes of fuchsia.
The best thing about this place, though, are the pools. There are four of them scattered throughout the grounds. The main pool is so big it could be mistaken for a lagoon, especially with its palm tree island. Next to it you have a waterslide and two twisty chutes. Smaller children have their own pool, and there's an adults-only number down by the beach.
On the food front, the main restaurant has a sleek monochrome look, with high-back chairs and funky spot-lighting. It offers up an international buffet, but during the summer you can also try one of the à la carte restaurants.
As for where you'll find it, the hotel fronts a great stretch of sand. The centre of Sousse is only five minutes away by taxi, but you've also got restaurants and bars closer to home.
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Buffet breakfast, lunch and dinner. All local drinks in restaurants and lounge - time restrictions will apply. Snacks at set times.
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Onsite waterpark May to Oct
There are plenty of slides here, with fast-paced Kamikaze drops to inflatable-ring rides. Kids over 5 years get their own fun-filled area, too.
Just so you know the waterpark is open from May-October and kids need to be at least 110cm tall to use the slides. The Aqua Tower is for little ones over 5 years, who must be supervised be an adult. Soft drinks are included in your All Inclusive package at the snack bar here.
Cleopatra buffet restaurant
For breakfast, lunch and dinner, head to the buffet restaurant where you'll find a selection of international dishes, plus local dishes, pizzas, grilled meat, fish, pasta and salads.
Elyssa spa*
Relax and indulge in one of the treatments offered at the spa, you can pick from a massage and a range of spa treatments. Whether it's a special occasion or you'd just like to treat yourself and there's a hairdresser too.
Rooms► View all
twin room
These twin rooms with their neutral backdrop and colourful soft furnishings sleep up to three or can be sold as a single. There's air-conditioning from June to September and heating from November to March for your comfort.
family room
These family rooms with their neutral backdrop and colourful soft furnishings sleep up to four with twin beds and extra beds. There's air-conditioning from June to September and heating from November to March for your comfort.