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Publications (55)116.68 Total impact
Article: Binge Drinking During Adolescence Disrupts Se Homeostasis and Its Main Hepatic Selenoprotein Expression[Show abstract] [Hide abstract]
ABSTRACT: Background Binge drinking (BD) is the most common ethanol (EtOH) intake consumption model among teenagers, but little is known about its effects on the liver. During its hepatic metabolism, acute alcohol exposure produces a great amount of reactive oxygen species which contributes to alcohol-induced liver injury. Selenium (Se) plays a key role in antioxidant defense as it forms part of selenoproteins, such as the antioxidant glutathione peroxidases (GPxs) or the selenoprotein P (SelP), synthesized mainly in liver. Chronic EtOH consumption decreases both Se deposits and this tissue's antioxidant activity.Methods Two BD administration routes (oral and intraperitoneal) were used in adolescent rats to analyze Se homeostasis; the main hepatic selenoproteins' expression: GPx1, GPx4, and SelP, and their biological roles related to oxidation. Their relationship with inflammatory processes was also determined by analyzing the expression of the transcriptional factor nuclear factor-kappa beta (NF-κB).ResultsIt has been demonstrated for the first time that BD in adolescents alters Se homeostasis regardless of the administration route employed, despite the fact that the BD oral group ingested less Se in diet. This decrease of Se in serum and liver is directly related to a decrease in serum GPx3 and hepatic GPx1 activity, contributing to the oxidative imbalance found. The depletion of Se detected in liver affects GPx1 expression and, surprisingly, GPx4 expression. This could be related to the lower expression of the transcriptional factor NF-κB in the liver, a key player in the regulation of inflammatory processes.Conclusions Due to the above, and to find whether a Se supplementation therapy improves these situations, it would be interesting to explore in more depth the relationship between Se, the high oxidation found, and the depressed immune response reported in BD adolescents.Alcoholism Clinical and Experimental Research 04/2015; 39(5). DOI:10.1111/acer.12707 · 3.21 Impact Factor
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ABSTRACT: Oxidative imbalance is one of the most important mechanisms to alcohol-induced injury. Acute alcohol exposure induces a great amount of reactive oxygen species during its hepatic metabolism via microsomal ethanol oxidizing system. During adolescence the deliver process is still taking place, therefore ethanol effects differ from that in adults. As binge drinking is the most important ethanol consumption model of ethanol intake used by adolescents, and few is known about its effects on liver, we have used two routes of acute ethanol administration (via oral and via intraperitoneal) in adolescent rats in order to analyze the oxidative damaged caused in peripheral and liver. It has been demonstrated for the first time that binge drinking in adolescent causes periphery oxidation of lipid and DNA, as well as lipid and protein hepatic oxidation, which are related to a lower glutathione peroxidise (GPx) activity, a higher catalase (CAT) activity, and a higher expression of NADPHoxidase, contributing to hepatic damage. In addition, it is also showed that intraperitoneal administration route increases oxidative damage, being probably related to the general stress response generated, that in the case of alcohol-exposed rats by via intraperitoneal, causes higher DNA and protein oxidation related to a higher NADPHoxidase expression and to a higher CAT and superoxide dismutase (SOD) activities. According to these results it were concluded that binge drinking induced hepatic damage during adolescence, at least in part, as consequence of oxidative stress since that the antioxidant mechanism delivered was insufficient to avoid liver oxidation. Alcohol administered via i.p provoked more oxidation in DNA than oral alcohol exposure model.Chemical Research in Toxicology 10/2014; 27(11). DOI:10.1021/tx5002628 · 3.53 Impact Factor
Article: Selenium dietary supplementation as a mechanism to restore hepatic selenoprotein regulation in rat pups exposed to alcohol[Show abstract] [Hide abstract]
ABSTRACT: Ethanol exposure during gestation and lactation decreases selenium (Se) intake, disrupting body Se balance and inducing oxidative stress in rat offspring. Selenium-supplemented diet (0.5 ppm) was administered to ethanol-exposed (20% v/v) dams during gestation and lactation. When the dams' pups were 21 days old, the pups' levels of the main hepatic selenoproteins glutathione peroxidase (GPx1 and GPx4) and selenoprotein P (SelP) were measured. The pups were divided into control (C), alcohol (A), control-selenium (CS), and alcohol-selenium (AS) groups. The purpose was to evaluate the effect of the selenium-supplemented diet on the levels of Se deposits present in the livers of their pups. Alcohol decreases hepatic Se deposits, GPx activity, and GPx1 expression; alcohol increases GPx4 and SelP expression. Se was measured by furnace graphite atomic absorption spectrometry, the antioxidant activity of GPx and concentration of hepatic phospholipids (PL) were determined by spectrophotometry, and the selenoprotein expressions were detected by Western blotting. Selenite treatment prevented alcohol's effects of diminishing the Se deposits, GPx activity, and GPx1 expression, while maintaining the high levels of the expression of GPx4 and SelP. These results suggest that depletion of hepatic Se levels in rat pups, caused by ethanol exposure to their dams, affects the synthesis of the 3 main hepatic selenoproteins in different ways, which is related to a decrease in GPx activity and PL concentration, and an increase in serum Se levels. Selenium supplementation to the dams increased the expression of GPx1, GPx4, and SelP in their pups.Alcohol (Fayetteville, N.Y.) 10/2013; 47(7). DOI:10.1016/j.alcohol.2013.07.004 · 2.01 Impact Factor
Article: Role of selenium and glutathione peroxidase on development, growth, and oxidative balance in rat offspring[Show abstract] [Hide abstract]
ABSTRACT: Selenium (Se), an essential trace metal, is important in both growth and reproduction and is the constituent of different selenoproteins. The glutathione peroxidase (GPx) family is the most studied as it prevents oxidative stress. Liver oxidation is considered as another mechanism involved in low birth weight. Therefore in order to ascertain whether GPx is related to the effects of Se on growth during gestation and lactation, three groups of rat pups were used: control, Se-deficient and Se-supplemented. Morphological parameters and reproductive indices were evaluated. Hepatic Se levels were measured by graphite-furnace atomic absorption while spectrophotometry was used for activity of antioxidant enzymes and oxidative stress markers in liver; and western blotting for expression of hepatic GPx1 and GPx4. The Se-deficient diet increased mortality at birth, decreased viability and survival indices and stunted growth, length and liver development in offspring, thus decreasing hepatic Se levels, GPx, glutathione reductase and catalase activities, while increased superoxide dismutase activity and protein oxidation. The Se-supplemented diet counteracted all of the above results. GPx1 expression was heavily regulated by Se dietary intake; however, although Se dietary deficiency reduced GPx4 expression, this decrease was not as pronounced. Therefore, it can be concluded that Se dietary intake is intimately related to growth, length, and directly regulating GPx activity primarily via GPx1, and secondly to GPx4, thus affecting liver oxidation and development. These results suggesting that if risk of uterine growth retardation is suspected, or neonates with low birth weight presents signs of liver oxidation, may be beneficial know about Se status.Reproduction 09/2013; 146(6). DOI:10.1530/REP-13-0267 · 3.17 Impact Factor
Article: Oxidative effects of chronic ethanol consumption on the functions of heart and kidney: Folic acid supplementation[Show abstract] [Hide abstract]
ABSTRACT: The principal aim of this study was to investigate the oxidative effects of chronic ethanol consumption on the functions of the heart and the kidney and the possible modification of this effect by folic acid supplementation. Moreover, in order to find whether this oxidative profile affects cardiovascular function, parameters such as heart rate and glomerular filtration rate were also assessed. Four experimental groups of rats were used: control, ethanol-exposed, control supplemented with folic acid and ethanol-exposed plus folic acid. Ethanol-exposed rats were subjected to a chronic ethanol treatment (2 months), in which the level of alcohol reaches 30% v/v. Diet and ethanol solution were provided ad libitum, and folic acid supplementation was 8 vs. 2 ppm. Energy intake, creatinine clearance and heart rate were determined. Antioxidant enzyme activity and lipid and protein peroxidation of the kidney and the heart were measured by the spectrophotometric method. Ethanol increases heart size and catalase (CAT) activity and decreases lipid peroxidation in heart without changing heart rate. However, in the kidney, ethanol decreases CAT activity, increases lipid peroxidation and decreases glomerular filtration rate. Folic acid supplementation avoids these situations; it does not, however, improve glomerular function. Chronic ethanol consumption has many effects on the antioxidant enzymatic activity of the heart and the kidney, leading to increased renal lipid peroxidation prevented by folic acid supplementation.Alcohol and Alcoholism 05/2012; 47(4):404-12. DOI:10.1093/alcalc/ags056 · 2.89 Impact Factor
Article: Selenium or Selenium Plus Folic Acid-Supplemented Diets Ameliorate Renal Oxidation in Ethanol-Exposed Pups[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Ethanol (EtOH) exposure during gestation and lactation induces an oxidative stress in offspring. In kidney, the oxidative damage is the primary pathway to alcohol-induced injury. In this study, we have demonstrated that a diet supplemented with selenium (Se) (0.5 ppm) or with Se (0.5 ppm) + folic acid (8 ppm) administered to EtOH-exposed (20% v/v) dams during gestation and lactation prevents the oxidative EtOH-provoked effects in their offspring's kidneys. METHODS: All the studies were performed on 21-day-old pups. Serum, urine, and kidney Se levels were assessed by graphite-furnace atomic absorption spectrometry. Se and creatinine clearance, antioxidant enzyme activities, and lipid and protein peroxidation were determined by a spectrophotometric method in kidney. RESULTS: Dietary supplementation treatments used could not improve the glomerular filtration function altered by EtOH exposure during gestation and lactation; however, they did improve renal Se deposits, renal development, and renal protein content while decreasing lipid and protein oxidation and modifying antioxidant enzymes' activity. CONCLUSIONS: Se or Se + folic acid supplementations improve renal development and protein content and modify antioxidant enzymes' activity, decreasing lipid and protein oxidation after EtOH exposure. In this context, a double-supplemented diet appears to reduce protein peroxidation more efficiently than the Se-only-supplemented one, probably via superoxide dismutase and catalase.Alcoholism Clinical and Experimental Research 04/2012; 36(11). DOI:10.1111/j.1530-0277.2012.01788.x · 3.21 Impact Factor
Article: The effects of ethanol upon hydric balance and arterial pressure in rats: Folic acid as a possible hypotensor[Show abstract] [Hide abstract]
ABSTRACT: Chronic alcohol intake is related to hypertension. There are, however, few studies concerning the effect of ethanol upon hydric balance in relation to arterial pressure. Folic acid intake has beneficial effects upon the cardiovascular system decreasing hyperhomocysteinemia, however, more studies imply that it is related with other mechanisms. Therefore, we have studied the effects of chronic alcohol intake (30% v/v) upon hydric-saline balance and hypertension and have found that dietary supplementation with folic acid (8 mg/kg) improves the above parameters. Our study used four experimental groups of rats: control, alcohol, alcohol with folic acid and control with folic acid. In all cases we measured the clearance of Na(+), K(+) and aldosterone; osmolarity in urine, liquid and solid ingestion; homocysteine levels in serum; cardiac frequency and arterial blood pressure. The alcohol intake increases serum aldosterone and homocysteine, which is reflected in an increase in arterial blood pressure. In addition, we have found that alcohol intake reduces both liquid and solid ingestion (causing a malnourishment status), the clearance of creatinine, aldosterone, Na(+) and K(+), and the ratio ClNa(+)/ClCr; it also increases urine osmolarity. Folic acid supplementation increases the clearance of Na(+) and the ratio ClNa(+)/ClCr. Folic acid intake improves the hypertension provoked by alcohol by increasing the aldosterone clearance, drastically reducing the serum levels of this hormone and thus its hypertensor effect.Life sciences 02/2012; 90(9-10):337-42. DOI:10.1016/j.lfs.2011.12.008 · 2.70 Impact Factor
Article: Effects of Antioxidant Supplementation on Duodenal Se-Met Absorption in Ethanol-exposed Rat Offspring In Vivo[Show abstract] [Hide abstract]
ABSTRACT: The nutritional deficiencies provoked by ethanol consumption, during gestation or lactation, can contribute to multiple birth defects in offspring. In order to improve our knowledge about selenium (Se) distribution in pups exposed to ethanol, the present study evaluated the effect of this drug on intestinal development and determined its action on duodenal absorption of selenomethionine (Se-Met). To determinate if supplementation could improve Se absorption and its serum values, we used two antioxidant supplemented regimens on dams, with selenium alone or selenium plus folic acid, and obtained six groups of pups: C (control), A (alcohol), CS (control + Se), AS (alcohol + Se), CFS (control + Se + folic acid) and AFS (alcohol + Se + folic acid). Duodenal Se-Met transport was performed using an in vivo perfusion method. Se levels were measured by graphite furnace atomic absorption spectrometry. The supplemented diets utilized had a positive influence on body growth, duodenal perimeter and Se content in ethanol-exposed pups. Ethanol exposure increased Se-Met duodenal absorption in all pups, supplemented or not, presenting the highest values of maximal velocity (V(max)) compared with their control counterparts. The affinity constant (K(m)) increased according to rank: A>AS>AFS groups. These results suggest that although antioxidant supplementation does not restore Se-Met absorption to normal values, it enhances the affinity of the transporters for the substrate and improves the damage caused by ethanol in the duodenal mucosa.Journal of Reproduction and Development 09/2011; 57(6):708-14. DOI:10.1262/jrd.11-049K · 1.52 Impact Factor
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ABSTRACT: The present study aims to compare selenium (Se) status in offspring rats born to selenium-deficient and selenium supplemented dams and to analyse Se's influence on intestinal parameters and the intestinal absorption of selenomethionine (Se-Met). Male and female Wistar rats (150-200 g) were randomised in: control (C) (0.1 ppm Se), Se-deficient (SD) (0.01 ppm Se) and Se-supplemented (SS) (0.5 ppm Se) groups; and were mated to obtain their offspring. Se levels in serum, urine and faeces in offspring and in mothers' milk were measured by graphite-furnace atomic absorption spectrometry. Duodenal transport studies in offspring were performed using an in vivo perfusion of different Se-Met concentrations (2, 5, 10, 25, 75 and 150 μM). KEY FINDING: A Se-deficient diet provoked a decrease in the offspring's body weight and intestinal parameters, while the supplemented diet increased these values. Serum Se levels were similar between Se-deficient and control offspring because the urinary excretion of Se was smaller to compensate for Se homeostasis. Intestinal Se-Met absorption obeys the Michaelis-Menten equation with lower apparent constant (K(m)) and maximal velocity (V(max)) in the SD group. However, the C and SS groups presented similar K(m) and different V(max). The V(max) showed greater values in the following order of rank: SS>C>SD groups. Selenium intake deficiencies in offspring lead to the development of compensatory mechanisms in order to normalise serum selenium levels. These mechanisms, however, do not permit normal body development; nor do they regulate intestinal parameters and Se-Met transport.Life sciences 11/2010; 88(3-4):150-5. DOI:10.1016/j.lfs.2010.11.006 · 2.70 Impact Factor
Article: Folic Acid and Selenite during Reproduction, Gestation and Lactation Protect against Ethanol Changed Se Bioavailability[Show abstract] [Hide abstract]
ABSTRACT: Levels of antioxidants such as folic acid and selenium decrease in dams exposed to ethanol during gestation and lactation, affecting their antioxidant status, their reproductive function and consequently the health of their progeny. We will study whether a Se (0.5 p.p.m.) plus folic acid (8 p.p.m.) supplemented diet administered to ethanol-exposed dams and male rats prevents the effects provoked by ethanol in Se bioavailability and in their glutathione peroxidase (GPx) activity, thus improving the health of their offspring. Se levels in tissue were measured by graphite-furnace atomic absorption spectrometry and serum GPx activity by spectrophotometry. Results show that ethanol decreases Se retention in dams, affecting their tissues' Se deposits, decreasing serum GPx activity, gestational parameters and the weight of their progeny. Se plus folic acid balance Se bioavailability, something that is especially important during gestation and lactation, and as a direct result, the health of their progeny is improved.Alcohol and Alcoholism 10/2010; 45(6):489-94. DOI:10.1093/alcalc/agq067 · 2.89 Impact Factor
Article: Selenium or selenium plus folic acid intake improves the detrimental effects of ethanol on pups' Selenium balance[Show abstract] [Hide abstract]
ABSTRACT: The levels of folic acid and selenium, two nutrients with antioxidant properties, decrease in dams exposed to ethanol during gestation and lactation. This decrease affects their antioxidant balance, and consequently the health of their offspring. In this study we have proved that a supplemented diet with Se (0.5 ppm) or with Se (0.5 ppm) plus folic acid (8 ppm) to ethanol-exposed (20%v/v) dams prevents the ethanol-provoked effects in their offspring's Se deposits. Se levels in milk, serum, urine, faeces and several tissues were measured by graphite-furnace atomic absorption spectrometry. Results show that ethanol decreases Se deposits in pups' heart, liver, kidney and testes. However Se levels in pancreas and in serum were increased by ethanol; it also compromised the weight and the length of the offspring at the end of lactation. Our supplemented diets to ethanol dams increased all of these impaired levels, and restored Se pancreas concentration to a control status. However Se-only therapy mainly displaces Se to serum, kidney and spleen, and co-treatment with Se plus folic acid, mainly displaces Se to liver and brain. This data demonstrate that the qualitative and quantitative Se organ deposits depend on ethanol consumption, Se status, and the presence of other antioxidants.Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 09/2010; 48(12):3486-91. DOI:10.1016/j.fct.2010.09.028 · 2.90 Impact Factor
Article: Trabajos tutorizados en la enseñanza de hematología para estudiantes de farmacia de la Universidad de Sevilla.[Show abstract] [Hide abstract]
ABSTRACT: El objetivo principal de este trabajo es fomentar el autoaprendizaje y la relación profesor-alumno. Esto lo conseguiremos promoviendo el seguimiento continuado del alumno mediante tutorías presenciales y virtuales, y la evaluación de varios temas del programa seleccionados por el profesor para ser abordados por los alumnos. La materia elegida, Hematología, forma parte de la Licenciatura de Farmacia. Este proyecto, dirigido a 400 alumnos, ha pretendido darles las bases metodológicas suficientes para elaborar un trabajo de calidad, mediante el desarrollo escrito de varios temas del programa, concretando la información, distinguiendo lo más importante de cada tema, participando en el desarrollo continuo de la materia, utilizando las tutorías como fuentes de información y mejorando sus calificaciones y autoaprendizaje. Como resultado mas importante a destacar de esta actividad, encontramos un elevado grado de participación por parte de los alumnos, que valoraron muy positivamente la experiencia. Como reflejo de esta satisfacción los resultados académicos mejoraron sustancialmente, hecho constatado al comparar las tasas de rendimiento y éxito respecto a las existentes de manera previa a la implantación de esta actividad de innovación.Ars Pharmaceutica 01/2010; 51(1).
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ABSTRACT: Nutrients such as folic acid and selenium are decreased in dams exposed to ethanol during gestation and lactation, affecting their metabolism, antioxidant balance, and the future health of their progeny. We will study whether the supplementation of the maternal diet with folate and selenium can prevent ethanol-induced oxidative liver disorders in the offspring. Dams were randomised into four groups: control, alcohol, alcohol+folic acid+Se, and control+folic acid+Se. We determined selenium by graphite-furnace atomic absorption and antioxidant enzyme activities, lipid peroxidation, and protein carbonyl by spectrophotometry in the offspring. Alcohol increased serum Se levels and glutathione peroxidase (GPx) activity. However, in the liver of pups from ethanol-exposed dams a decrease in selenium was provoked and GPx activity increased with the double supplementation. Glutathione reductase (GR) and catalase (CAT) activities increased with ethanol, while double supplementation significantly decreased the GR activity. The supplemented diet reduced the protein peroxidation found in ethanol pups. These results suggest that folic acid+Se could be effective in neutralising the damage of ethanol consumption in pups since it prevents peroxidation protein products.Birth Defects Research Part B Developmental and Reproductive Toxicology 12/2009; 86(6):490-5. DOI:10.1002/bdrb.20211 · 0.77 Impact Factor
Article: Ethanol Consumption by Wistar Rat Dams Affects Selenium Bioavailability and Antioxidant Balance in Their Progeny[Show abstract] [Hide abstract]
ABSTRACT: Ethanol consumption affects maternal nutrition, the mothers' antioxidant balance and the future health of their progeny. Selenium (Se) is a trace element cofactor of the enzyme glutathione peroxidase (GPx). We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three groups of pups. Se levels were measured by graphite-furnace atomic absorption spectrometry. Serum and hepatic GPx activity was determined by spectrometry. We have concluded that ethanol decreased Se retention in dams, affecting their tissue Se deposits and those of their offspring, while also compromising their progeny's weight and oxidation balance. These effects of ethanol are caused by a reduction in Se intake and a direct alcohol-generated oxidation action.International Journal of Environmental Research and Public Health 09/2009; 6(8):2139-49. DOI:10.3390/ijerph6082139 · 2.06 Impact Factor
Article: Selenium tissue distribution changes after ethanol exposure during gestation and lactation: Selenite as a therapy[Show abstract] [Hide abstract]
ABSTRACT: Ethanol consumption affects maternal nutrition and antioxidant status together with the future health of their progeny. Selenium (Se) is a trace element with antioxidant activity; we will study the effect of ethanol in dams on Se bioavailability, antioxidant balance and gestational parameters. We also will study if a Se-supplemented diet (0.5 ppm) administered to ethanol-exposed dams avoids the undesirable effects provoked by ethanol. We have used four experimental groups: control (C); chronic ethanol (A); control+Se (CS) and chronic ethanol+Se (AS). Se levels in serum, urine, faeces, and several tissues were measured by graphite-furnace atomic absorption spectrometry. Serum glutathione peroxidase (GPx) activity was determined by spectrometry. Se bioavailability is altered by ethanol, causing a decrease in Se retention, reducing Se levels in cortex, muscle, mammary gland and salivary gland while elevating Se values in heart, liver and spleen. On the other hand, Se supplementation increases some of these parameters. Serum GPx activity was decreased by ethanol, while a Se-supplemented diet restores these values to those found in controls. We have demonstrated that ethanol decreased Se retention in dams, affecting their tissues' Se deposits, decreasing GPx activity in serum, gestational parameters and the weight of their progeny. Selenite supplementation counteracts these decreasing effects, except in cortex.Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 08/2009; 47(10):2484-9. DOI:10.1016/j.fct.2009.07.006 · 2.90 Impact Factor
Article: Beneficial Role of Dietary Folic Acid on Cholesterol and Bile Acid Metabolism in Ethanol-Fed Rats[Show abstract] [Hide abstract]
ABSTRACT: Cholesterol metabolism is altered by chronic ethanol consumption. In previous articles, we demonstrated the anti-oxidant capacity of folic acid, which may be useful in the prevention of damage provoked by ethanol. We want to determine the effects of ethanol on cholesterol and bile metabolism and whether a folic acid-supplemented diet could change alterations provoked by a chronic ethanol intake in rats. We used four experimental groups: (1) control, (2) alcohol, (3) alcohol supplemented with folic acid, and (4) control supplemented with folic acid. In all the experimental groups, we measured hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and cholesterol and bile acids in serum, liver, bile, and feces. We have found that the alcohol-fed groups showed high hepatic HMG-CoA reductase activity, total hepatic and serum cholesterol concentration, bile cholesterol secretion concentration, and cholesterol enterohepatic circulation. Total serum and hepatic cholesterol levels decreased when alcohol-fed rats were supplemented with folic acid. The hepatic bile acid concentration increased in both chronic ethanol groups. Folic acid supplementation significantly increased bile cholesterol secretion, the bile acids in bile, and fecal bile acid excretion in ethanol-exposed rats. The independent bile acid fraction showed no significant differences between both ethanol groups with respect to Na+, K+, and Cl- concentrations. Folic acid increases bile flow, bile acid synthesis from cholesterol, and bile acid excretion via feces, thus provoking a decrease in serum and hepatic cholesterol. However none of these actions were observed in supplemented control rats. This, therefore, could be yet another beneficial effect of folic acid on alcoholic patients.Journal of studies on alcohol and drugs 08/2009; 70(4):615-22. DOI:10.15288/jsad.2009.70.615 · 2.76 Impact Factor
Article: Effect of Maternal Ethanol Consumption during Pregnancy and Lactation on Kinetic Parameters of Folic Acid Intestinal Transport in Suckling Rats[Show abstract] [Hide abstract]
ABSTRACT: Ethanol ingestion is known to interfere with folate absorption and metabolism. A fostering/crossfostering analysis of maternal ethanol exposure effects on jejunum and ileum kinetic parameters in vivo of offspring rat folic acid absorption at 21 days postpartum was carried out. The rats were divided into four groups: CP, control pups; GP, pups exposed to ethanol only during gestation; LP, pups exposed to ethanol only during lactation; GLP, pups exposed to ethanol during gestation and lactation. Jejunal and ileal loop transport studies were performed using in vivo perfusion at a flow rate of 3 ml/min for 5 min. Folic acid concentrations of 0.25, 0.5, 1, 1.5 and 2.5 microM: were used. Jejunal and ileal absorption values were determined by the difference between the initial and the final amounts of substrate in the perfusate and expressed as picomoles per square centimeter of intestinal surface every 5 min. The results indicated that ethanol consumption by the dams during gestation and/or lactation led to significant changes in V(max), with no significant changes in apparent K(m). These findings suggest that exposure to ethanol during gestational and suckling periods leads to a general delay in postnatal body weight and that intestinal folate absorption appears to be upregulated in suckling rats, this effect being higher in the LP group.Journal of Membrane Biology 11/2007; 219(1-3):63-9. DOI:10.1007/s00232-007-9062-8 · 2.46 Impact Factor
Article: Response of the exocrine pancreas to the CCK on offspring rats of ethanol dams. Effects of folic acid[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to study the reverse effect of folic acid administered during gestation and lactation to ethanol-treated dams, on cholecystokinin Cholecystokinin (CCK) stimulus-secretion coupling in pancreatic exocrine secretion in offspring rats. Animals were randomized into three groups: Control group (C) received water and basic diet during pregnancy and lactation period; ethanol-treated rats (E) received ethanol and basic diet; the ethanol+folic acid group (EF) received folic acid supplement concomitantly with ethanol administration. Body and pancreatic weight was lower in offsprings after ethanol treatment. Folic acid supplementation increased these parameters with respect to ethanol rats. After CCK stimulation, a significant decrease in amylase, lipase and chymotrypsin activities in the duodenal juice were detected in ethanol, this trend was partially corrected with folate supplementation. Ethanol exerts its action on exocrine pancreatic secretion by two pathways: 'per se' and diminishing the folic acid content, because a folic acid supplement in rats during pregnancy and lactation periods produces an advantageous effect on amylase, lipase and chymotrypsin secretion in their offspring. Although extrapolation from animal studies may be tenuous, the present findings may explain the use of folic acid in the prevention of ethanol-induced damage by increasing the enzyme levels to adequate physiological concentrations.Alcohol and Alcoholism 05/2007; 42(4):277-84. DOI:10.1093/alcalc/agm034 · 2.89 Impact Factor
Article: Effects of prenatal or postnatal ethanol consumption on zinc intestinal absorption and excretion in rats[Show abstract] [Hide abstract]
ABSTRACT: The effect of ethanol consumption, either during the pregnancy or lactation period, on the altered metabolism of zinc is not well-defined; consequently, this study was performed to analyze the effect of chronic ethanol exposure on milk consumption, serum, milk, duodenal absorption, fecal and urinary excretion of zinc in dams and offspring during either gestation or lactation in the rat. A complementary study was performed regarding pregnancy outcome. We evaluated testosterone values, the offspring born/litter and several indices such as fertility, viable gestations and the survival index. To study the effect of chronic alcoholism during gestation or lactation separately, at birth control newborns were cross-fostered to ethanol dams (ED), and the offspring issued from the ethanol treated mothers were cross-fostered to control dams (CD). Thus, three experimental groups of offspring were formed: (i) control offspring receiving no treatment (CO); (ii) offspring exposed to ethanol only during gestation (GO); and (iii) offspring exposed to ethanol only during lactation (LO). All the results were compared with offspring pair-fed groups (PFO) born of the pair-fed dams (PFD). Duodenal absorption of zinc increased significantly in LO offspring when the substrate concentrations in the perfusion medium were 25, 75, and 150 microM. A higher faecal excretion in GO pups compared with those with LO exposure and control groups (CO and PFO). The urine excretion of zinc was higher for LO offspring with respect to the other three experimental groups (CO, GO, and PFO). Maternal adaptation resulted in zinc retention, adequate to meet the demands of pup's growth in the face of a lower diet intake. The zinc status in pups is regulated by a higher absorption of zinc and intestinal conservation of endogenous fecal zinc after postnatal ethanol consumption. The increase in urinary zinc excretion could be responsible for decreased serum zinc. However, we found an increase in serum zinc probably due to an increase in the zinc absorption values.Alcohol and Alcoholism 10/2006; 42(1):3-10. DOI:10.1093/alcalc/agl084 · 2.89 Impact Factor
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ABSTRACT: S-adenosylmethionine (SAM) is an universal methyl donor for biological systems in transmethylation reactions. Another metabolic pathway involving S-adenosylmethionine is initiated with the release of -CH3 from the molecule and the formation of S-adenosylhomocysteine and then homocysteine and cysteine, a precursor of the main cellular antioxidant glutathione. Chronic ethanol consumption could affect the bioavailability of amino acids such as methionine. Our purpose was to determine the effect of chronic alcohol feeding during gestation or lactation on hepatic S-adenosyl-methionine, S-adenosylhomocysteine, DNA methylation and homocysteine serum concentration at the end of the lactation period (21-day-old offspring). Wistar dam rats were fed with alcohol during periconceptional, gestation and lactation periods (alcohol-fed rats). This study was conducted with three groups of offspring with different periods of alcohol exposure: control offspring (C), no treatment; and gestation (G) and lactation (L) offspring, exposed to alcohol only during gestation or lactation, respectively. To obtain these last two groups of offspring, on parturition day control newborn rats were cross-fostered to alcohol-fed dams (L) and alcohol new-born rats were cross-fostered to control dams (G). In conclusion, these results indicate that exposure of rats to ethanol during the lactation period affects SAM values more severely than ethanol exposure only during gestation.Addiction Biology 07/2005; 10(2):139-44. DOI:10.1080/13556210500123043 · 5.36 Impact Factor
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Universidad de Sevilla
Hispalis, Andalusia, Spain
- • Departamento de Fisiología
- • Facultad De Farmacia


text:
Financial Markets:
Issuers, Purchasers, and Purposes of High Yield, Non-Investment Grade Bonds
GGD-88-55FS: Published: Feb 29, 1988. Publicly Released: Feb 29, 1988.
Additional Materials:
- Full Report:
(202) 512-4800
In response to a legislative requirement, GAO provided information on high-yield, non-investment-grade bonds, focusing on the: (1) issuers and purchasers of such bonds; (2) reasons for issuing such bonds; and (3) extent of risk, in comparison to other kinds of investments, such bonds represent to federally insured institutions.
GAO found that: (1) the amount and value of the bonds increased significantly between 1982 and 1987, from 57 bonds, valued at $2.8 billion, to 193 bonds, valued at $31.3 billion; (2) companies in a wide variety of industries issued high-yield bonds; (3) mutual funds and insurance companies purchased about 30 percent of high-yield bonds, with pension funds, individuals, and thrift institutions purchasing between 7 and 10 percent; (4) federally insured thrift institutions owned about $11.1 billion in such bonds, representing about 0.9 percent of their total net assets; (5) 10 thrifts held about 78 percent of such bonds, representing 3 to 34 percent of their total net assets; (6) 5 of the 10 thrifts had varied investment policies and procedures and loss reserve amounts; (7) companies issued the bonds for general corporate purposes, debt retirement, and acquisition; and (8) high-yield bonds accounted for 22 percent of the total financing used for hostile corporate takeovers in 1985 and 1986.
Sep 23, 2015
Corporate Bankruptcy:Stakeholders Have Mixed Views on Attorneys' Fee Guidelines and Venue Selection for Large Chapter 11 CasesGAO-15-839: Published: Sep 23, 2015. Publicly Released: Sep 23, 2015.
Sep 15, 2015
Confidential Informants:Updates to Policy and Additional Guidance Would Improve Oversight by DOJ and DHS AgenciesGAO-15-807: Published: Sep 15, 2015. Publicly Released: Sep 15, 2015.
Jun 29, 2015
Youth Athletes:Sports Programs' Guidance, Practices, and Policies to Help Prevent and Respond to Sexual AbuseGAO-15-418: Published: May 29, 2015. Publicly Released: Jun 29, 2015.
Jun 19, 2015
Federal Prison System:Justice Could Better Measure Progress Addressing Incarceration ChallengesGAO-15-454: Published: Jun 19, 2015. Publicly Released: Jun 19, 2015.
May 28, 2015
U.S. Parole Commission:Number of Offenders under Its Jurisdiction Has Declined; Transferring Its Jurisdiction for D.C. Offenders Would Pose ChallengesGAO-15-359: Published: May 28, 2015. Publicly Released: May 28, 2015.
Apr 29, 2015
Victims of Child Abuse Act:Further Actions Needed to Ensure Timely Use of Grant Funds and Assess Grantee PerformanceGAO-15-351: Published: Apr 29, 2015. Publicly Released: Apr 29, 2015.
Mar 23, 2015
Department of Justice:Alternative Sources of Funding Are a Key Source of Budgetary Resources and Could Be Better ManagedGAO-15-48: Published: Feb 19, 2015. Publicly Released: Mar 23, 2015.
Mar 16, 2015
Criminal History Records:Additional Actions Could Enhance the Completeness of Records Used For Employment-Related Background ChecksGAO-15-162: Published: Feb 12, 2015. Publicly Released: Mar 16, 2015.
Mar 4, 2015
Whistleblower Protection:Additional Actions Needed to Improve DOJ's Handling of FBI Retaliation ComplaintsGAO-15-343T: Published: Mar 4, 2015. Publicly Released: Mar 4, 2015.
Feb 23, 2015
Whistleblower Protection:Additional Actions Needed to Improve DOJ's Handling of FBI Retaliation ComplaintsGAO-15-112: Published: Jan 23, 2015. Publicly Released: Feb 23, 2015.
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Weather News
Sydney bakes during hottest day on recordFriday January 18, 2013 - 15:39 EDT
Sydney has officially recorded its hottest day on record, with the mercury reaching 45.8 degrees at Observatory Hill.
The searing temperature equates to about 114 degrees on the old Fahrenheit scale.
The previous record was 45.3 degrees in January 1939.
Across greater Sydney, the hottest temperature recorded so far has been at Camden which reached 46.4 degrees shortly after 3:00pm, but that is still short of the record for the western suburbs.
Aaron Coutts-Smith from the Weather Bureau says other records could still be broken.
"We're keeping a very close eye on it," he said.
"They can still continue to rise this afternoon, it's really contingent on the sea breeze and when that decides to kick in and move further inland."
Grass fires have been springing up around Sydney areas as temperatures soar across the city.
A grass fire in the rail corridor at Kingsgrove has lead to trains bypassing stations on the Airport and East Hills line in Sydney's south.
New South Wales Fire and Rescue crews have also put out fires in parks in Yennora in the south-west and Penrith in the west.
Paramedics feel the heat
The New South Wales Ambulance Service has been flooded with calls for people seeking help for heat exposure.
At least 21 people have called the ambulance service seeking help for heat exposure.
A further 84 calls have been received for unconsciousness, fainting and vomiting which the Ambulance Service says can also be attributed to heat stress.
In the last ten days 182 people called on paramedics seeking emergency treatment for heat stress.
Chief Superintendent Ian Johns says that figure is just the tip of the iceberg.
"We get hundreds more calls for people complaining of heat related illness," he said.
"People call 000 for dizziness or vomiting or headache or generally unwell or collapse, and when the paramedics get there and do some assessment it can be attributed to the excessive heat.
"People underestimate the heat and overestimate their ability and that would be particularly so for younger fitter Australians."
Elderly people and those with chronic illness need to be especially careful.
"The risk to these people goes up exponentially," Mr Johns says.
"These are the people we're most concerned for, they're over represented in particularly hot days like we've got today and like we've had over the last week."
Mr Johns says preparation is the key.
He's advising people to take simple measures such as wearing a hat, carrying water and staying out of the heat.
"The better you can prepare yourself, the better chance you have of getting through these extreme weather days with your health intact.
"Stay out of the heat, stay hydrated, stay cool, and stay in touch with those in your family and community that might suffer in today's high temperatures."
More breaking news
ABC News
Sydney Morning Herald
National Nine News
News Limited
Weather News
From sweltering to sweaters in Adelaide
Adelaide residents will be swapping singlets for sweaters from Sunday.
A stormy week ahead for the southeast
A broad, slow moving trough is currently traversing southeastern parts of the nation and will continue to move east in the coming days.
How drought pushed well-known Queensland cattle breeder to move to King Island for rainfall
A well known Queensland stud cattle breeder says years of drought and the changing climate is why his family sold its Queensland property and relocated half their herd to King Island.


text:
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text:
By Elizabeth Kahurani
2010, the Peruvian government announced a commitment to preserve a total of
54 million hectares of forest and reduce the country NET deforestation to zero
by 2021. The implementation to reduce emissions from deforestation and
forest degradation (REDD+)
has been seen as a strategy to achieve that ambitious goal.
researchers looking at REDD+ Readiness in Peru, find that action and progress
over a period of three years (2011-2013) has been minimal. They used an analytical
framework on REDD+ Readiness developed by the ASB Partnership to
evaluate Peru's progress in setting up the needed structures and processes to
implement the UN led mechanism.
by the framework, interviews with key REDD+ stakeholders were conducted to
understand how the country scored on functions required in a country's REDD+
Readiness process –Planning and
Coordination; policy, institutional, and legal framework; MRV and audit;
Demonstration and Pilots; Financing; Benefit sharing. These were measured
against defined progress indicators.
found that progress was limited due to a number of factors captured in three
main areas –lack of leadership and capacity to coordinate and engage with
different sectors, a gap in knowledge of the processes driving deforestation
and appropriate trans sectoral policy responses, hence the need for a stronger
integration of REDD+ into national and regional plans," says Dr Valentina
Robiglio, Climate Scientist at the World Agroforestry Centre in Latin America
and lead author of the study.
instance, important government ministries, civil society, and communities had
not been involved from the beginning and that has hindered efforts. "The start
towards REDD readiness process was rapid, championed mainly by international
partners, donors, international and national experts. As such, much of the
ground work that was required for a conducive political environment and
institutional cross-sector coordination was bypassed," says Dr Robiglio.
further noted that failure to understand the social-political context within
which deforestation and degradation happens led to crucial gaps in planning for
the readiness process through the identification of priority areas for
study recommends integration of REDD strategies into policies and ensuring
linkages between national and subnational functions to aid towards clarifying
rights, land allocations, land-use monitoring and thus ensure equity and
efficiency in benefit sharing.
Beyond REDD+ readiness: Land-use governance to reduce
deforestation in Peru article is part of a journal special issue Climate Policy vol.14, no. 6 focusing
on The Political Economy of Readiness
for REDD+. All articles in this issue are open access.
Citation: Robiglio, V., Armas,
A. D., Aguad, C. S., White, D. 2014 Beyond REDD+ readiness: land-use governance
to reduce deforestation in Peru. Climate
Policy 14 (6) 734-747
Scientists with the ASB Partnership for the Tropical Forests Margins at the World Agroforestry Centre have published a special issue in Climate Policy vol.14, no. 6, that focuses on the Political Economy of Readiness for REDD+, guest edited by Dr Peter Minang and Dr Meine van Noordwijk. All articles in this special issue are available for free as "open access" publications.
According to the special issue, the process of REDD+ readiness is
shaped by a host of complex political and economic factors largely
influenced by the national environment, history and circumstances
specific to each country.
"The game changes at country level, and the process has to account
for complex political and economic realities involving multiple actors,
institutions, political and sectoral ideologies that require an
iterative, rather than a simple linear, global process," says Dr Peter
Minang, one of the special issue editors.
Read entire blog from Climate Strategies and climate policy journal blog.
Contact - (Lima,
Peru) +254 721 537627; firstname.lastname@example.com
Contact – (Lima,
Peru) +254 708 159934 firstname.lastname@example.com
Contact – (Nairobi, Kenya)
+254 717718387; firstname.lastname@example.com;
; www.asb.cgiar.org
Managing landscapes effectively in the
face of climate change means untangling a host of complications
Today, scientists are looking at
the world in terms of landscapes, which are units of the environment with some
common theme. It is no good studying a lake unless the forest above it that
supplies water is considered, along with the people that fish in the lake and
use its water for agriculture. Landscapes can be small, like a valley, or
enormous, like the Serengeti plains. But even the simplest landscape can have many
different populations, uses and values, all of which might be competing with
each other.
How can all these needs be
satisfied, while conserving the landscape for the future? A book entitled 'Climate-Smart
Landscapes: Multifunctionality In Practice' which will be launched by the World
Agroforestry Centre, Nairobi, Kenya, on the fringes of the Global Landscapes
Forum in Lima, Peru on 7 December, goes some way towards answering the
To feed a projected population of
more than 9 billion by 2050, food production must grow by more than 50 percent.
Growing competition over fixed land resources means that economically attractive
land uses triumph over those that are more valuable from a society perspective,
but less profitable for a private land user.
Landscapes in the tropics and
subtropics are at the heart of this competition for land, partly because they have
the highest population growth as well as increases in agricultural land. As a
result, planning of land use can no longer be the business of single interests,
but needs to involve all interested parties. Hence, the increasing requirement
for an approach to the landscape that will satisfy everyone's needs yet maintain
the different functions going on in the landscape while conserving it for the
future, that is, making it sustainable.
This is already a complicated
challenge. Traditionally, scientists would address a complex problem by
breaking it down into its component parts and addressing them one at a time.
This does not work in a landscape, which typically has any number of
stakeholders with different perspectives, interests, power and ambitions, which
can often be conflicting. "Multifunctionality' in a landscape is about seeking
to achieve many different objectives at the same time," said Peter Minang, one
of the editors of the book and Global Coordinator of the ASB Partnership for
the Tropical Forest Margins. "Planning land use can no longer be the business
of single interests, but needs to involve all interested parties. Hence the
increasing requirement for a landscape approach."
Complicating this situation even
further is the problem of climate change. Agriculture produces a lot of
'greenhouse' gases that speed up climate change. There is a worldwide movement
now to create 'climate-smart' agriculture, which reduces the amount of
greenhouse gases produced yet still allows farmers to grow food and make a
profit, while preparing for the effects that climate change might have on them,
like rising temperatures that increase diseases in their crops.
"Sustainable multifunctional
landscapes is a common destination that can be reached from many possible
starting points," said Meine van Noordwijk, Chief Scientist at the World
Agroforestry Centre. Once the wider range of options and perspectives are
understood, it is possible to influence the various tradeoffs between functions
and stakeholders in different and potentially better ways."
"In the tea-growing landscape of
Kericho in Kenya, governmental bodies, farmer and community organizations, and
private sector tea producers, have come together to define key investments for
a climate-smart landscape," said Jeffrey C. Milder, the Rainforest Alliance's
lead scientist and chief advisor for biodiversity and ecosystem conservation.
"This process identified landscape planning and coordination as among the most
strategic opportunities, requiring modest investment while aligning existing
activities across the landscape to improve tea productivity, watershed health,
and biodiversity."
"Despite evolving institutions
governing land and trees in Cameroon, disputes over land and forest rights have
grown rather than diminished, leading to changing land use patterns and in some
cases increasing land degradation," said Divine Foundjem-Tita, a marketing
scientist based at the World Agroforestry Centre's Yaounde office. "The main
message in this case study is that formal, informal or hybrid institutions are
indispensable features in landscapes, and are crucial to landscape management,
as they shape the patterns and functions of landscapes."
"For current landscapes to move
towards their full potential, all the interested parties have to agree on a
vision for change," summed up Peter Minang. "This democratic approach will
allow climate-smart landscapes to contribute meaningfully to sustainable
The book, Climate-Smart Landscapes: Multi-functionality in
Practice will
be launched on the sidelines of the UNFCCC COP 20 in Lima, Peru during the Global
Landscapes Forum on Saturday, 6 December 2014 at 12.15pm, MEDIA ROOM
About the World Agroforestry Centre (ICRAF)
World Agroforestry Centre (ICRAF) is a
leading, international science-based research and development institution in
the tropics, and a member of the Consultative Group on International
Agricultural Research (CGIAR). For 30 years, the World Agroforestry
Centre and its partners have worked with poor rural farmers throughout the
tropics to develop innovative agroforestry-based practices that help them
manage their limited resources. The Centre's vision is the transformation
of lives and landscapes across the developing world through massive use of
trees and agroforestry innovations. Its mission is to generate science-based
knowledge about the diverse role trees play in agricultural landscapes and use
its research to advance policies and practices to benefit the poor and the environment.
For more information, go to www.worldagroforestry.org/ or follow ICRAF on Twitter @ICRAF
By Glenn Hyman and Valentina Robiglio
lot of research and development deals with different aspects of reducing
emissions from forest degradation and deforestation (REDD+). But how can we
really get change on the ground? Last week collaborators of the ASB Partnership for
the Tropical Forest Margins presented an approach to low emissions development planning to the Directorate of Land Use Planning and the National Forest Conservation Program, Programa Bosques, of the Ministry of Environment of Peru (MINAM) in a three days demonstration
William Llactayo of MINAM opened the
meeting was hosted by the Ministry of Environment of Peru (MINAM) and
involved researchers from the World Agroforestry Center (ICRAF) and the International Center for
Tropical Agriculture (CIAT). Participants from the various
directorates of the MINAM were trained in the Land-Use Planning for Low Emission Development Strategies
(LUWES) methodology, which consists of the development of future
land use and zoning scenarios and the calculation of the impacts of land use
change on greenhouse gas emissions. Working in groups and using ABACUS software, they combined information
on land-use, carbon stocks and profitability for land-use systems in the
Ucayali region where research on this topic has been carried out by the
ASB partners over several years. The results included an analysis of
opportunity costs of avoided deforestation, estimates of CO2
emissions under different scenarios and the calculation of a reference
emissions levels for REDD+.
MINAM is
now evaluating the possibility of implementing this methodology in their
land-use planning processes. Given that every region of the country has a
mandate to create land-use plans, this process could be a vehicle for including
considerations on the reduction of greenhouse gas emissions and the
conservation of other ecosystem services in development plans. The
expectation is that efforts to reduce emissions can be more efficient if they
are connected to land-use planning processes. Read in Spanish
Working groups discussed low emissions
In 2014, the ASB Partnership celebrates twenty years of high impact
scientific research on options to combat deforestation while improving
livelihoods in the tropical forest margins. It is a partnership that has
consistently championed the issue of deforestation and has had far reaching
effects and contributed to global debates and initiatives on environment,
particularly on climate change.
Over the years, ASB Partnership has worked with local communities, governments and scientists in finding compromise between livelihood needs, development and environmental conservation
More than 50 institutions through multidisciplinary and long-term
co-location of research in benchmark sites across the humid tropics have published
more than 1000 scientific publications, including articles, books and book
chapters; as well as over 40 signature ASB policy briefs that have become
popular with various audiences and especially policy and decision makers.
"The evolution of ASB can well be compared to the story of the phoenix
bird that rises after earlier incarnations crashed and burned in the sense that
the partnership has had to change and renew focus after challenging afresh old
and existing theories," says Dr Meine vanNoordwijk, Chief Scientist at the
World Agroforestry Centre who was among pioneers of the ASB Partnership.
During phase I of the partnership, the hypothesis was to stop
deforestation through agricultural intensification, maximizing on yields in
available agricultural land in order to spare forests. With time however it was
realized that this could actually lead to more deforestation as agriculture
became more profitable. Phase II was an effort to explore whether
intensification would work if integrated with appropriate policies, technology
and institutional reforms through a win-win hypothesis. This approach
encountered challenges on implementation particularly across scale from local to
national government. This led to Phase III of incentives hypothesis where
environment and development needs could be met with the right mix of incentives
supported not just by the governments in developing countries but through
global investments such as payments for ecosystem services.
The partnership is currently at Phase IV -sharing-sparing-caring
hypothesis- where emphasis has been on a multifunctional landscape approach to
emission reduction. Through the Reducing Emissions
from All Land Uses project, ASB is among pioneer institutions to provide
evidence on the need for a landscape approach to reducing emissions from
deforestation and forest degradation (REDD+), as it overcomes implementation
challenges related to a narrow focus on forests. This has been picked up in
various forums with negotiators at the last United Nations Framework Convention
on Climate Change Conference of the Parties (UNFCCC COP 19) saying that a
landscape approach is the next best alternative to REDD+. A global forum on
landscapes was also held for the first time at the margins of COP 19.
"The success of the ASB Partnership lies in the diverse, dynamic,
multidisciplinary team of scientists drawn from national and international
research institutes, universities, community organizations, and farmer's
groups," says Dr Peter Minang, ASB Partnership Global Coordinator.
The ASB approach provides the right mixes of disciplines to test
various theories and working with communities informs their practicality and
application on the ground.
"Going forward, ASB will continue to work on issues around the
agriculture-forest interface," says Dr Minang. "Shifting cultivation remains a
huge challenge in the Congo Basin and more attention would thus be given to
that part of the world. Overall, research will focus on promoting
multi-functionality in landscapes along tropical forest margins in the context
of green economic development."
Over the next 20 years, ASB Partnership hopes to continue reporting
positive impact on lives, livelihoods, forests and ecosystem services.


text:
Tuesday, October 13, 2015
Alternate title: It Happened on July 20
Two films concerning the July 20, 1944 plot to kill Adolph Hitler were released in Germany within the same week. The second to arrive on the scene was G. W. Pabst's Es Gescham am 20 Juli. Actor/director Bernhard Wicki heads the cast as Oberst Graf Von Staufenberg, the prime mover of the assassination conspiracy. The reasons for Von Staufenberg's actions are never fully articulated; the film is more concerned with the mechanics of the plot and the placing of the bomb. Though Hitler never appears in Es Gescham am 20 Juli, Joseph Goebbels does, by way of newsreel footage; cleverly, director Pabst allows Goebbels to betray himself as the jabbering lunatic and craven coward that he really was. ~ Hal Erickson, Rovi


text:
International Game Technology PLC said that Wynn Resorts has signed an agreement to install IGT systems applications at Wynn Las Vegas, Wynn Palace in Macau and Wynn Everett in Massachusetts. more
By Lori Stabile
The state's general fund received $381.9 million from the R.I. Lottery in fiscal 2015, an increase of $5.6 million compared with the previous year, according to the lottery's audited financial statements. more
By PBN Staff
In a time when casinos are proliferating across the region, Megan McGuinness' job is to find new ways to entice patrons to choose her clients over the competition. McGuinness, owner of McGuiness Media & Marketing LLC, entered the casino … more
By Eli Sherman | email@example.com | 10/2/15
Hope & Main, the nonprofit culinary business incubator, is celebrating its first birthday, along with the 100th birthday of its building, the Main Street School, on Oct. 11 with a turn-of-the-century-themed fall festival. more
By Lori Stabile
Cable Car Cinema is one of 23 theaters nationwide selected for the Sundance Institute Art House Project, designed to recognize theaters in North America with excellence in programming, community involvement and operations. more
By PBN Staff
GTECH Corp. has signed a four-year extension agreement with the Nebraska Lottery, International Game Technology PLC announced recently. T more
By PBN Staff
Acushnet Co., the maker of Titleist golf equipment, is talking to banks about a possible initial public offering in the U.S., people with knowledge of the matter said. more
By Vinicy Chan and Alex Barinka
Brian Schaffer has been promoted to director of golf at Alpine Country Club. He has more than 13 years of experience in the golf industry. He was elected as a Class A Professional by the PGA of America in 2008. more
Last year, entrepreneur and former U.S. Senate candidate B. Barry Hinckley began thinking about Rhode Island's reputation as a boating destination, and about a way to connect boaters with each other. more
By Lori Stabile
International Game Technology PLC said it has launched a new website, www.IGT.com, to help visitors understand its business. more
By Lori Stabile


text:
I've just moved our WordPress installation from http://radiofreemoscow.org/wordpress/ to the root folder, http://radiofreemoscow.org/
Since then, when logged in, there is no Admin link in the top horizontal links, and no Edit link for the individual posts. I've gone to the Customize Chameleon theme and changed Menu Login/Logout Link? and Menu Admin/Register Link? from Yes to No and back again, but this hasn't helped. Any ideas what is going on, and what I can do to fix this?
Thanks in advance.


text: SDN Members don't see this ad. (About Ads) I just failed out of medical school, failed too many classes 4th semester. At my medical school basic sciences is made up of 4 semesters thus I failed at the very end of basic sciences. Because of personal and financial reasons, I've decided to abandon the medical school route and am interested in applying to PA school. I've basically studied Anatomy, Physiology, Biochem, Pharm, Path, Micro and did fair in those classes (with the exception of my 4th semester). My case is probably fairly unique but how will that "background" affect my application to PA school? Also, another question- do most PA schools have lectures on powerpoint to download? Just wondering b/c my study style relies heavily on the use of powerpoint slides.


text:
Originally posted on Fox Sports South | Last updated 2/2/13
ATLANTA (AP) -- Luol Deng had 25 points and 14 rebounds, and the short-handed Chicago Bulls used their stifling defense to shut down the Atlanta Hawks in a 93-76 victory on Saturday night. Playing without injured starters Kirk Hinrich, Joakim Noah and Carlos Boozer, Chicago dominated near the basket and got a lift from the frenetic play of Nate Robinson. The Bulls used only eight players for the second straight night, but it was more than enough for an impressive road win. Taj Gibson had 19 points and matched his career high with 18 rebounds. Jimmy Butler added another double-double with 16 points and 10 rebounds. Robinson went 4 for 6 from 3-point range and finished with 20 points. Josh Smith led Atlanta with 19 points and 13 rebounds but he scored only three points in the second half. Jeff Teague scored 16, and Al Horford had 14 points and 12 rebounds. Bulls coach Tom Thibodeau said Hinrich had a procedure in Chicago on Saturday to have an infection cleaned out of his right el...
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text:
'The Briefcase:' What Would You Do in This Situation?
If you where given $100,000 would you give it all away to a family just as deserving as yours, give them a portion of the money or keep it all for yourself?
The Briefcase premiered last week on CBS, posing this very question to two well deserving families.


text:
I've recently obtained a MacBook Pro Late 2011 13" (for my bday!!!) and I was messing around with Windows 8 Consumer Preview and found that the x64 edition has the /efi/boot/bootx64 already made.
The disk booted and installed fine (through UEFI). Then when you goto reboot when you press Option at the start up chime you get the 'EFI Boot' hard drive icon!!!!!
When you select it you will boot to the desktop and have running Windows 8 Consumer Preview. All through UEFI. The one problem with this is sometimes audio doesn't work and it is somewhat unstable and will occasionally refuse to boot and you have to force restart.
I've made a video on this booting and everything check it out!!
I've also posted this in Apple Hardware
Just trying to get the word around!!!
More info to come!!
3 replies to this topic
Posted 04 March 2012 - 02:57 PM
Posted 26 April 2012 - 11:58 PM
Nice but I'm a little surprised. Wouldn't that mean Windows 8 has lower EFI version requirements (<1.1) than Windows 7 (2.0).
- 2040Tech likes this
Posted 27 April 2012 - 01:43 AM
No actually Windows 8 probably is booting in a different way through UEFI
Nice but I'm a little surprised. Wouldn't that mean Windows 8 has lower EFI version requirements (<1.1) than Windows 7 (2.0).
and newer Macs have a lot of 2.0 UEFI components in them for example: GOP, NetBoot, etc..
Posted 12 August 2012 - 11:09 PM
Yep, My audio driver isn't work & I have met BlueScreen !
Also tagged with one or more of these keywords: Windows, UEFI, Apple, BOOTCAMP, BOOT, EFI
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from The American Heritage® Dictionary of the English Language, 4th Edition
- n. See tachina fly.
- adj. Of or belonging to the family Tachinidae.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any insect of the family Tachinidae, especially the tachina fly
from The Century Dictionary and Cyclopedia
- n. Same as tachinarian.
Results of the experiments described above demonstrated that tachinid parasitoids and Tiphia sp. were more abundant in diverse bean plots than in bean monoculture.
1. Designing integrated pest management for sustainable and productive futures.
The effects of strip-cropping haricot bean (Phaseolus vulgaris L.) with maize (Zea mays L.) under weedy and weed-free conditions on the abundance of tachinid parasitoids and a predatory wasp that are associated with African bollworm were studied at Awassa, southern
1. Designing integrated pest management for sustainable and productive futures.


text:
|Key Info
This charming Bed & Breakfast is situated in a beautiful historic 16 th-century house in Rome. The area offers direct train connections to Fiumicino International Airport and central Rome.
The B&B is located on the first floor and is indipendent and separate,is suitable for children and group til 8 people.
The B&B features 3 private and quiet bedrooms which are each equipped with air conditioning, free Wi-Fi and a TV. Each bedroom includes a double bed and more beds can be added for extra guests. All bedrooms include a bathroom with a modern shower. Fresh bed linen and towels are provided.
Guests have access to a shared kitchen where a delicious breakfast is served. An outdoor seating area is also available on the patio of the green garden.
Villa Bonelli Train Station is just 100 metres away for direct connections to the historic centre of Rome. Fiumicino International Airport is just a 20 journey via the FL1 Train. The picturesque Trastevere District can be reached within 10 minutes' via public transport.
Children until 12 years old don't pay if they sleep in the same room of parents
Smalls pets are kindly allowed.
Free luggage storage is possible on the day or arrival and departure
|Sleeps up to 8, 3 bedrooms
|3 bedrooms, 3 bathrooms of which 2 Family bathrooms and 1 En suites
|Will consider
|Corporate bookings
|Car not necessary
|Family friendly
|Great for children of all ages
|Pets welcome, Yes, smoking allowed
|Internet access, DVD player
|Central heating, Air conditioning, TV, Fax machine, Wi-Fi available
|Kettle, Toaster, Iron, Hair dryer
|Cooker, Microwave, Fridge, Freezer, Washing machine
|1 Sofa beds, Double beds (3), Dining seats for 8
|Linen provided, Towels provided
|Balcony or terrace, Shared garden, BBQ, Bicycles available
|Parking, Not suitable for wheelchair users
Villa Bonelli neighborhood is far with car from the city center just 5km and is really well conncted with public transport, you will reach trastevere in 5 minutes and Underground stop in 10minutes, moreover the station ( 3 minutes by foot) links directly to Fiumicino Airport (six train stops for 8€ )
in the neighborhood there is markets, bakery , grocery, pharmacy, laundry service and unicredit bank, we also provide for bicicles for free for reach them.


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Teave ja võimalused noortele kogu Euroopas.
Oumeng.eu is a new platform that brings together information and tips on various topics of interest for Chinese speakers interested in the EU and its Member States, as part of an increasing EU-China cooperation.
Olemasolevad keeled
The European Youth Parliament encourages you to take an interest in current affairs and the democratic process, practice independent thinking and take personal initiative. Do you want to take part?
Olemasolevad keeled


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"We may get several thousand sets of such measurements over the course of a single experiment," said DiMaggio.
When seemingly similar histones are broken into small fragments, differences in the locations of modifications become more apparent. The computer algorithm -- based on an area of math called integer linear optimization -- repeatedly compares all the fragments until it produces a highly accurate list of modifications and their locations.
"To see separation of nearly identical species and identify and quantify them with high confidence is very exciting," said Young. He also noted that of the many millions of combinations of modifications possible only a few hundred actually appear in real human cells. This observation implies that combinations of these relatively few modifications form a code that can now be deciphered.
The next step will be to link specific patterns of modifications with observable changes in cells. For example, when normal cells transform themselves into cancerous cells, scientists could track the corresponding changes in the histones. Similarly, scientists could identify particular histone codes that are required for stem cells to change into specific tissue types, such as nerve cells or insulin-producing cells. Understanding and potentially reprogramming these processes could have important implications for regenerative medicine, cancer and other diseases.
As a start, the researchers are collaborating with biologists from the University of California- Los Angeles to identify histone codes relevant for stem cell behavior. "We've shown we can measure modified histone forms, but there's so much to do now," said Garcia. "This is really the beginning of some true biological breakthroughs."
|Contact: Steven Schultz
Princeton University, Engineering School


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Fuel tanker drivers work on the road, transporting fuel from the designated pick-up point to the customers' locations. A driver may work for a single company or as an independent contractor working directly with customers. Fuel tanker drivers must be able to load and unload fuel tankers, follow strict safety guidelines, properly label materials, and keep track of other paperwork and records. Experience with valves, pumps, wrenches, and other tools needed to load and unload the tanker are essential, and drivers must have strong driving skills to handle a variety of weather and light conditions.Read More...
Depending on the company, fuel tanker drivers may be full time, part time, or on call. Shifts may be during day or evening hours; for local transporting jobs, many deliveries must be completed within a single day.
Fuel tanker drivers are required to have a Class A commercial driver's license, as well as an endorsement of proper hazmat and tanker training. In general, fuel tanker drivers are required to have a high school diploma or equivalent. They must be over the age of 18 for in-state work and 21 if driving in multiple states. Many fuel tanker driving jobs require at least one year of experience with driving tractor-trailer-tankers.
Median of all compensation (including tips, bonus, and overtime) by years of experience.
|Extremely satisfied
Rated 5 out of 5
based on 71 votes.
3 %
97 %
|Medical: 79%
|Dental: 57%
|Vision: 48%
|None: 19%


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19 Iconic Movie Quotes Updated for 2015
When Harry Met Sally
35 Hilariously Stupid Things Real People Have Actually Done on a First Date
First dates can be awkward because you never know exactly what you're getting into. But thanks to Happn, an exciting new take on dating apps that just arrived stateside from Paris, you can decide if you want that date with that intriguing (and real-life, not online) stranger before you ever even talk to them.
Try Happn for free today and avoid these hilariously honest (and true) stories from ever happening to you….
Chris Pratt is Letting the Internet Design His New Facebook Picture
Not only is actor Chris Pratt known as the star of Parks and Rec and Jurassic World, but he's also known as being one of the coolest guys around.
Need proof?
When he was in the market for a new header for his Facebook page, instead of hiring some fancy designer, he decided to do a contest with his fans (plus, as he puts it, he doesn't know Photoshop).
He asked only that the image feature his most famous characters — Peter Quill, Owen, Andy, and Emmet — as well as "eagles, American flags, guns, cool ford raptors, cigars, explosions" and "some cool guns or rollerblades," among his other favorite things.
Along with Pratt noticing (and mentioning) you as the winner, you might also get "a free dinner at Applebee's or something like that."
Needless to say, Pratt fans fired up their computers and started creating, and Pratt is personally looking through all the submissions himself. Although the winner is yet to be announced, here's a selection of the best and weirdest so far, but be sure to visit Pratt's page to check out the rest — and maybe enter your own.
25 Tinder Fails That Prove the Internet Is Full Of Weirdos
Dating is hard. Theoretically online dating should make things easier (you don't even have to leave the house to try and find a date) but in reality, not so much. It's shocking, but people can actually exaggerate their profiles online. I know. Outrageous.
That's where Tinder comes in. If you're not familiar, the app forces users to make impulse decisions based on physical appearances to engage in a conversation. If you like what you see and read, you swipe right to chat. If you don't like what you see, swipe left.
Easy enough and, after all, what quality relationship doesn't start with physical appearances and phones?
Dina Disaster
Via: Reddit
This Fake Customer Service Facebook Page Is Winning the Internet
I don't think I've ever experienced having to sit on hold with customer service and having patience at the same time. I understand it's a very difficult job and they deal with a bunch of, shall we say, "difficult" people, but see previous sentence. People don't generally call them because they're so happy.
With that said, there is a parody Facebook customer service page — WeHopeThatHelps.com — that responds to customer complaints on brand pages. Even though they don't represent the company getting complaints, their comments are rarely deleted.
The only explanation is that they're hilarious and they're also saying what real customer service people wish they could say but that they can't because it wouldn't be professional.
And let's be honest, who wouldn't want to say this?
False advertising?
35 Older People Being Unintentionally Awesome on Facebook
Senior citizens were raised in a time before even basic telephones were a household thing, so you really can't blame them for being confused when it comes to using "The Facebook."
But for those that gave it a shot, we are eternally grateful for the LOLs — even if they don't really know what that means.
Via: Imgur
Help Solve the Mystery of the Bewitching Women In These Gorgeous Vintage Found Photos
A few weeks ago, photographer Meagan Abell was thrift store shopping in Richmond, Virginia, when she came across a box of film negatives. Curious about the images, she bought the negatives, took them home, and scanned them…
And was absolutely stunned by the photographs' beautiful, moody atmosphere.
The devastatingly gorgeous results show two young women, bathed in the rosy, golden light of the setting sun, standing on a beach, and walking into the ocean.
Unfortunately, the owner of the thrift store has no idea where the photos came from though, judging by the style of dress, Abell's best guess is that they were take in the 1940s or 1950s. She thinks the film is most likely 60mm, and may be Kodachrome.
But beyond that, the incredible photographs and their subjects are a total mystery.
So Abell turned to Facebook to help her solve the mystery. Using the hashtag #FindTheGirlsOnTheNegatives, tens of thousands of people have shared the images and are busy searching for the mystery women…
And, so far, there have been a few developments.
'Smelfies' Show Us What It's REALLY Like to Be a Dad
Four months ago, Australian comedian Adam Hills decided to share his diaper changing experience with the Twitterverse, coining the term #smelfie.


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As of the beginning of August, the research vessel Polarstern will then set course for the Arctic Ocean. The focus will be on physical, biological and chemical changes in the central Arctic. The reduction of sea ice and the variability of ocean circulation and its heat and fresh water budgets are tightly linked with changes in the gas exchange as well as with biogeochemical and ecosystem processes in the sea ice and in the entire water column. To understand these interrelations better, the members of the expedition will take water and ice samples from the shallow Eurasian shelf seas all the way to the deep Canadian Basi
|Contact: Ralf Roechert
Helmholtz Association of German Research Centres


text:
This content has been marked as final. Show 3 replies
1. Re: How to change ORA_BIPS_NQID cookie name?Sasi Nagireddy May 14, 2014 12:04 AM (in response to user955029)
Could you elaborate?
2. Re: How to change ORA_BIPS_NQID cookie name?user955029 May 16, 2014 11:48 AM (in response to Sasi Nagireddy)
Updated question with details of how to change ORA_BIPS_NQID cookie name but I am still struggling with how to modify the ORA_BIPS_LBINFO cookie name
3. Re: How to change ORA_BIPS_NQID and ORA_BIPS_LBINFO cookie name?user955029 May 21, 2014 9:34 PM (in response to user955029)
Is there any configuration similar to SessionIDCookieName in instanceconfig.xml that can change the ORA_BIPS_LBINFO cookie name? Any documentation on these ORA_BIPS oracle cookies? For example:
ORA_BIPS_NQID,ORA_BIPS_LBINFO and ORA_BIPS_ATGKEY?


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|Online applications are now open for school year 2016-2017.
|Spots are filling up quickly, so be sure to sign up for the Admission Office's CAIS 101 being held Thursday, November 12, 9:00 -10:30 a.m. at our new 888 middle school campus!
|Fall Enrichment class descriptions are available now for families to peruse. Registration is open at the Ultracamp website.
|Some spots are still available at the 2015 Party Sign Ups!
|China Faculty Institute a resounding success!
The inaugural group of CAIS faculty and staff participants in the China Faculty Institute travelled to China's Yunnan province this summer..
|Congratulations to the Class of 2015
CAIS's graduation ceremony showcased the talent, spirit, warmth and wit of the Classes of 2015 and 2018..
|Academic Success All Around for CAIS
MATHCOUNTS + SCIENCE FAIR + SPELLING BEE ADDS UP TO VICTORY CAIS's Advanced Mathcounts team earned first place out of 17 teams competing in the regional competition at Presidio Middle School..


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They feel bad, so they found you these other deals to make up for it.
Select Local Merchants
A-WOL: Dance CollectiveRead MoreWhether they're dangling from a tree, a club's ceiling, or pull-up bars inside the studio, A-WOL's cohort of dancers dazzles with a unique combination of dance and aerial fitness. Classes range from aerial yoga to trapeze, helping participants fly through the air like projectile cream pies. Instructors ensure that each participant soars safely by building a strong foundation before testing out skills and tricks.2303 N Randolph Ave.Portland, OR US
Eugene OperaRead More"Eugene Opera," wrote the Eugene Weekly in a 2013 profile, "is helping make opera relevant to 21st-century Oregon." But the company isn't just working on creating a new generation of fans, it's pushing the future of the art form forward. To that end it stages daring contemporary works that present relevant social issues, from the examination of the prison system in Jake Heggie's Dead Man Walking to the study of mythology in John Adams' Nixon in China. Yet it certainly hasn't forgotten the classics. Since its debut performance of Carmen in 1976 the opera regularly sprinkles its seasons with hallowed works by the likes of Stephen Sondheim and Puccini. Contemporary works aren't the only way the company looks forward, either. Their Artist Mentor Program sends members of the opera chorus into the community to interact with students and young musicians, while the Eugene Opera Academy gives high schoolers with interest in any element of the productions a chance to get their hands dirty.1 Eugene CenterEugene, OR US
Premier Acamdemy of Performing ArtsRead MoreEnjoy a night of theater in Salem. Premier Acamdemy of Performing Arts has the wit and drama for you in their current season. Go from "I don't dance" to "I love dance!" with help from classes at Premier Acamdemy of Performing Arts. Parking is plentiful, so guests can feel free to bring their vehicles.135 19th St SESalem, OR US
Mt Hood Ballet AcademyRead MoreFor some of the best theater around, come to Mt Hood Ballet Academy in Gresham. Mt Hood Ballet Academy offers instruction in a number of dance styles, from classical to modern. Parking is plentiful, so guests can feel free to bring their vehicles.28 NE 4th StGresham, OR US
Northwest Conservatoryof DanceRead MoreFor a swinging good time in Hillsboro, follow the music to Northwest Conservatoryof Dance. Learn how to tell a story with your body at Northwest Conservatoryof Dance — with so many great dance classes to choose from, you may very well seek out more than one style. Parking is plentiful, so visitors can feel free to bring their vehicles.1055 NE 25th AveHillsboro, OR US
Hula Hālau 'Ohana Holo'oko'aRead MoreSince 1998, the instructors at Hula Halau 'Ohana Holo'oko'a—Hawaiian for "School Of Hula Where Everyone Is Family"—have carried on the traditions of their native language, song, and dance by teaching the hula to generations young and old. Hula illustrates a story through dance and music, often accompanied by a ukulele, guitar, or drum. Newcomers start out with the basic hula steps and movements, learning Hawaiian vocabulary and songs to prepare them for advancement to more complicated movements and a steady diet of only poi smoothies. Other classes teach students how to strum the ukulele and dance the tahitian brand of hula.5597 Southwest Arctic DriveBeaverton, OR US


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The place, date, time and competitors have all been set ... A Lightweight tournament had been in the works for World Series of Fighting (WSOF) for some time. And thanks to a recent announcement, we k read news >>
UFC heavyweight champion Fabricio Werdum will reportedly get his wish of fighting rival Cain Velasquez in a Brazilian football stadium in their rematch, as the Brazilian confirmed the bout is likely read news >>
The United States Anti-Doping Agency, or USADA, has completed what they're calling the first round of testing of UFC fighters and posted the results on a new athlete test history website. The agency read news >>
You know that crazy December frenzy Ultimate Fighting Championship (UFC) has planned to close out 2015? Well, Fabricio Werdum wants in on it. According to a report from "UFC Tonight," the UFC Heavywe read news >>
UFC heavyweight champion Fabricio Werdum is ready to defend his title. And he doesn't want to wait until March of 2016. At the UFC 191 post-fight press conference in Las Vegas this past weekend, UFC read news >>
The historic UFC 200 now has an official date and location. The card will be held on July 9, 2016, and will be the company's first event at Las Vegas Arena. UFC president Dana White formally announce read news >>
"The California kid" has a return date and it's the stacked UFC 194 pay-per-view (PPV) event. UFC 194 (full fight card here) already contains a stellar quartet of champions and challengers like Jose read news >>
A thumb injury derailed Robbie Lawler's plans to defend his welterweight title against Carlos Condit at UFC 193, but it didn't take long for the two sides to reschedule their bout. According to UFC.c read news >>
I grew up thinking every Marine was like Gunnery Sergeant Thomas Highway, so this video takes some getting used to. Nevertheless, star-struck serviceman Jarrod Haschert was fortunate enough to get Ul read news >>
The first in a solid stretch of pay-per-view events to close the year begins on Saturday with UFC 191. Go inside the numbers ahead of the card at MGM Grand Garden Arena in Las Vegas. Filed under: Fea read news >>
The UFC bantamweight champion's speculative dating life may be front page news right now, but she's put one piece of information on the record, that she'll go to the Marine Corps Ball with Jarrod Has read news >>
The date for Ronda Rousey's next title fight has been moved up by nearly two months as Dana White took to Sports Center on Friday to announce she'll be headlining UFC 193 in Melbourne, Australia on N read news >>
A confident U.S. Marine has asked Ronda Rousey out on a date. read news >>
Hey guys, I'm trying to take Ronda Rousey to the Marine Corps Ball this year and I need your help to reach out to her and her fans. Please share this post and video. Thank you!! Posted by Jarrod Hash read news >>
Nate Diaz is back, ladies and gentlemen, with the UFC announcing on Monday night that Stockton, California's native son will return to the Octagon on December 19 at UFC on Fox 17. His opponent? Surgi read news >>


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Stocks |
Opel says GM to spend 230 mln euros at German technology centre
BERLIN, April 24
BERLIN, April 24 General Motors' Opel division said on Wednesday that its U.S. parent will invest 230 million euros ($299 million) in new facilities at the automaker's Ruesselsheim, Germany-based research and development centre.
The planned investments will be rolled out over the next three to four years, Opel said in an emailed statement. GM said earlier this month that it plans to spend 4 billion euros on its European operations through 2016. ($1 = 0.7683 euros) (Reporting by Andreas Cremer; Editing by Christoph Steitz)
Our top photos from the last 24 hours. Slideshow


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'Image quality is superb, although the shiny screen can be distracting if you're working in a brightly lit room.'
'The keys are flat and springy; the layout lacks a full number pad, but that's far from a dealbreaker on a multimedia notebook.'
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'spacious keyboard'
'its 320GB hard drive is blissfully free of bloatware.'
'It is too heavy for sub-notebooks. 14 inch displays are normal for this class of weight.'
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'the N200's speakers emit tinny, soft sound'
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'Super Pi Super PI is a program that forces the processor to calculate Pi to 2 million digits of accuracy, here's a comparison of how the Satellite A205 with its 1.66GHz processor faired against other laptops: HDTune Benchmarks HDTune tests the peformance for the hard drive performance, below is a screenshot of the performance results for the hard drive that came with this configuration of the A205: ( view large image ) Comparison table for PCMark05 PCMark05 is a synthetic benchmark tool that tests overall system performance, here's how the Satellite A205 stacked up to other laptops: Heat and Noise For classroom use, this laptop won't disappoint.'
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$8,999 2016 Piaggio MP3 500 Sport ABSPiaggio · Denton, TX2016 Piaggio MP3 500 Sport ANTI LOCK BRAKES, 2016 Piaggio MP3 500 Sport ANTI LOCK BRAKES INCREASED TECHNOLOGY AND INCREASED SAFETY. STAND...Cycle Center And Bmw Of Denton ·4 days ago on Cycle Trader
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$3,750 2009 Piaggio MP3 TrikePiaggio · Palisade, CONo 1 builds a scooter like the Italians! Brought to you by the same company that manufactures Vespa, this 3 wheeled scooter has 2 indepen...Marketplace User ·Over 4 weeks ago on ClazTools
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$3,750 Piaggio MP3 250 Trike ScooterPiaggio · Black · Palisade, CONo 1 builds a scooter like the Italians! Brought to you by the same company that manufactures Vespa. thisthree wheeled scooter has 2 inde...Motoplex ·Over 4 weeks ago on V12 SoftwareTools
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