text:
|Publication number
|Publication type
|Application number
|Publication date
|Apr 17, 2007
|Filing date
|Jul 16, 2004
|Priority date
|Jun 29, 2001
|Fee status
|Also published as
|Publication number
|David M. Reilly, Alan D. Hirschman, David M. Griffiths, Currie Crookston
|Original Assignee
|Medrad, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (1), Referenced by (15), Classifications (14), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a divisional of U.S. application Ser. No. 10/201,880, filed on Jul. 24, 2002, now U.S. Pat. No. 6,767,319, which is a continuation of U.S. application Ser. No. 10/185,290, filed on Jun. 27, 2002, now abandoned, which claims priority to U.S. Provisional Application Serial No. 60/301,962, filed on Jun. 29, 2001, the contents of which are incorporated herein by reference.
The present invention relates to delivery methods, systems and components thereof for use with hazardous or toxic pharmaceutical substances, and especially to delivery and injection methods, systems and components thereof for use with radiopharmaceutical substances.
As used herein, the term "pharmaceutical" refers to any substance to be injected or otherwise delivered into the body (either human or animal) in a medical procedure and includes, but is not limited, substances used in imaging procedures (for example, contrast media) and therapeutic substances. A number of such pharmaceutical substances pose a danger to both the patient and the personnel administering the substance if not handled and/or injected properly. Examples of hazardous pharmaceuticals include, but are not limited to, radiopharmaceuticals, biological pharmaceuticals, chemotherapeutic pharmaceuticals and gene therapeutic pharmaceuticals.
Examples of use of a radiopharmaceutical include positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), which are noninvasive, three-dimensional, imaging procedures that provide information regarding physiological and biochemical processes in patients. The first step in producing PET images or SPECT images of, for example, the brain or another organ, is to inject the patient with a dose of the radiopharmaceutical. The radiopharmaceutical is generally a radioactive substance that can be absorbed by certain cells in the brain or other organ, concentrating it there. For example, fluorodeoxyglucose (FDG) is a normal molecule of glucose, the basic energy fuel of cells, to which is attached a radionuclide or radioactive fluor. The radionuclide is produced in a cyclotron equipped with a unit to synthesize the FDG molecule.
Cells (for example, in the brain), which are more active in a given period of time after an injection of FDG, will absorb more FDG because they have a higher metabolism and require more energy. The radionuclide in the FDG molecule suffers a radioactive decay, emitting a positron. When a positron collides with an electron, an annihilation occurs, liberating a burst of energy in the form of two beams of gamma rays in opposite directions. The PET scanner detects the emitted gamma rays to compile a three dimensional image.
In that regard, after injecting the radiopharmaceutical, the patient is typically placed on a moveable bed that slides by remote control into a circular opening of the scanner referred to as the gantry. Positioned around the opening, and inside the gantry, are several rings of radiation detectors. Each detector emits a brief pulse of light every time it is struck with a gamma ray coming from the radionuclide within the patient's body. The pulse of light is amplified, by a photomultiplier, and the information is sent to the computer that controls the apparatus.
The timing of injection is very important. After the generation of the radiopharmaceutical, a countdown begins. After a certain time, which is a function of the half-life of the radionuclide, the radiation level of the radiopharmaceutical dose falls exactly to a level required for the measurement by the scanner. In current practice, the radiation level of the radiopharmaceutical volume or dose is typically measured using a dose calibrator. Using the half-life of the radionuclide, the time that the dose should be injected to provide the desired level of radioactivity to the body is calculated. When that time is reached, the radiopharmaceutical dose is injected using a manually operated syringe.
Most PET radionuclides have short half-lives. Under proper injection procedures, these radionuclides can be safely administered to a patient in the form a labeled substrate, ligand, drug, antibody, neurotransmitter or other compound normally processed or used by the body (for example, glucose) that acts as a tracer of specific physiological and biological processes.
Excessive radiation to technologists and other personnel working in the scanner room can pose a significant risk, however. Although the half-life of the radiopharmaceutical is rather short and the applied dosages are themselves not harmful to the patient, administering personnel are exposed each time they work with the radiopharmaceuticals and other contaminated materials under current procedures. Constant and repeated exposure over an extended period of time can be harmful.
A number of techniques used to reduce exposure include minimizing the time of exposure of personnel, maintaining distance between personnel and the source of radiation and shielding personnel from the source of radiation. In general, the radiopharmaceuticals are typically delivered to a nuclear medicine facility from another facility equipped with a cyclotron in, for example, a lead-shielded container. Often, the radiopharmaceutical is manually drawn from such containers into a shielded syringe. See, for example, U.S. Pat. No. 5,927,351 disclosing a drawing station for handling radiopharmaceuticals for use in syringes. Remote injection mechanisms can also be used to maintain distance between the operator and the radiopharmaceutical. See, for example, U.S. Pat. No. 5,514,071, disclosing an apparatus for remotely administering radioactive material from a lead encapsulated syringe.
In one procedure, the radiopharmaceutical is injected into tubing that is coiled within a lead container. Typically, the shielded syringe used to inject the radiopharmaceutical is disconnected and replaced by a larger syringe, filled in most cases with saline, for injection into the body and flush. By emptying the second syringe, the radiopharmaceutical is flushed through the shielded, coiled tubing in the container and injected into the person to be scanned. An excess volume of saline supplies a flushing function.
Although substantial effort is made to reduce exposure of administering and other personnel to harmful radiation, some exposure is experienced under current procedures. Being in the injection room longer than necessary is thus to be avoided. Moreover, the cumulative radiation exposure resulting from multiple injection procedures must be closely monitored to avoid overexposure. Indeed, personnel that administer radiopharmaceuticals are typically periodically rotated out of such duties to reduce the risk of overexposure.
In addition to the difficulties introduced by the hazardous nature of radiopharmaceuticals, the short half-lives of such radiopharmaceuticals further complicate the administration of a proper dosage to a patient. As discussed above, initial calibration of radioactivity is often made and the injection is then timed so that a dose of the desired level of radioactivity to the body is delivered (as calculated from the half-life of the radiopharmaceutical). See, for example, U.S. Pat. No. 4,472,403 in which a motor driven syringe is controlled to inject a quantity of a radiopharmaceutical stored in the syringe by calculating the injection quantity based upon the half-life of the radiopharmaceutical and the delay before injection.
Radiation detectors have also been placed upon syringe shields and in line with the radiopharmaceutical delivery system. For example, U.S. Pat. No. 4,401,108 discloses a syringe loading shield for use during drawing, calibration and injection of radiopharmaceuticals. The syringe shield includes a radiation detector for detecting and calibrating the radioactive dosage of the radiopharmaceutical drawn into the syringe. U.S. Pat. Nos. 4,562,829 and 4,585,009 disclose strontium-rubidium infusion systems and a dosimetry system for use therein. The infusion system includes a generator of the strontium-rubidium radiopharmaceutical in fluid connection with syringe for supplying pressurized saline. Saline pumped through the strontium-rubidium generator exits the generator either to the patient or to waste collection. Tubing in line between the generator and the patient passes in front of a dosimetry probe to count the number of disintegrations that occur. As the flow rate through the tubing is known, it is possible to measure the total activity delivered to the patient (for example, in milliCuries). Likewise, radiation measurements have been made upon blood flowing through the patient. For example, U.S. Pat. No. 4,409,966 discloses shunting of blood flow from a patient through a radiation detector.
The danger to administering personnel and other difficulties that arise from the nature of hazardous pharmaceuticals such as radiopharmaceuticals often affect the quality and safety of the injection procedure. For example, given the care that must be taken to prevent radiation overexposure (including limiting the duration of injection procedures), the concern with properly timing an injection and the need to prevent the creation of radioactive wastes, it is often difficult to properly eliminate air from all fluid paths before an injection begins.
It is thus very desirable to develop devices, systems and methods through which toxic or hazardous pharmaceuticals (for example, radiopharmaceuticals) can be administered in controlled manner to enhance their effectiveness and patient safety, while reducing exposure of administering personnel to such hazardous pharmaceuticals.
In one aspect, the present invention provides a method of injecting a hazardous pharmaceutical comprising the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. The ports of the fluid delivery set can, for example, include luer connectors as known in the medical arts to form a removable, secure and generally sealed connection.
The method preferably further includes the steps of (i) removably connecting a disposable fluid path that is connectable (via, for example, a catheter) to a patient to the fluid delivery set and (ii) purging air from the disposable fluid path before connecting the fluid delivery set to the source of hazardous pharmaceutical.
By removing air from the fluid delivery set and the patient fluid path before any connection is made to the source of hazardous pharmaceutical, exposure of administering personnel to the hazardous pharmaceutical to that point is eliminated. Connecting the fluid delivery set to the source of pharmaceutical can be automated or otherwise accomplished remotely (for example, with use of an extending or robotic arm as known in the machine and robotic arts) to prevent exposure during that connection.
The pressurizing unit can, for example, be a syringe in operative connection with the powered injector. In the case that the pressurizing unit is a syringe, the method can further include the steps of drawing the hazardous pharmaceutical into the syringe and injecting the hazardous pharmaceutical through the fluid delivery set and the disposable fluid path. Using a powered injector having a control unit removed in distance or shielded from the position of the syringe, fluid delivery set and fluid path prevents exposure of operating/administering personnel to the hazardous pharmaceutical. The method preferably further includes the step of flushing the fluid delivery set and the disposable fluid path after injection using the flushing fluid (for example, saline and/or another biologically acceptable flushing agent). A powered injector can also be used with a saline syringe in a similar manner as described above to limit exposure of operating personnel to the hazardous pharmaceutical.
In the case that the hazardous pharmaceutical is a radiopharmaceutical, the method can further include the step of measuring the level or dosage of radioactivity of the radiopharmaceutical injected. Preferably, the level of radioactivity or dosage is measured very near in time or simultaneously with delivery of the radiopharmaceutical to provide an accurate measurement of the dosage delivered. For example, the level of radioactivity can be measured by positioning the syringe within a dose calibrator. The level of radioactivity can also be measured by placing a radioactivity detector in operative connection with a line through which the radiopharmaceutical is dispensed or delivered.
In another aspect, the present invention provides a system for delivery of a hazardous pharmaceutical including: a syringe in operative connection with a powered injector and a protective container to enclose the syringe during operation thereof. The protective container is constructed or adapted to protect personnel from detrimental effects of the pharmaceutical. The system preferably also includes at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set. The fluid delivery set preferably includes a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable.
The valve assembly preferably provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set. The valve assembly also preferably provides flow control through the fluid delivery set such that the entire fluid delivery set can be purged of air with the syringe and the source of flushing fluid in fluid connection with the valve assembly before the source of pharmaceutical is connected to the fluid delivery set. In one embodiment, the valve assembly includes a bypass line in continuous fluid connection between the source of flushing fluid and the fluid path.
In the case that the pharmaceutical is a radiopharmaceutical, the protective container can, for example, be a component of a dose calibrator adapted to measure the level of radioactivity of the pharmaceutical within the syringe. In one embodiment, the syringe is connected to the powered injector via an extending adapter that preferably extends from the powered injector when connected thereto to position the syringe within the protective container.
The adapter can, for example, include an injector attachment member to attach the adapter to a powered injector and a plunger extension fixed in position relative to a powered injector. The plunger extension preferably has a plunger attachment member to attach to a plunger of the syringe. In one embodiment, the adapter also includes a syringe carriage slidably attached to the adapter. The syringe carriage includes a syringe attachment member to removably attach a syringe thereto so that a barrel of a syringe can be moved relative to a plunger thereof to control fluid flow into and out of a syringe.
The above embodiment of an adapter facilitates orientation of the syringe tip or exit of the syringe directed toward the powered injector when the syringe is attached to the syringe attachment member. This orientation can facilitate purging of air from the syringe when the syringe is placed within, for example, a dose calibrator positioned below the injector. In that regard, lead-shielded dose calibrators are often relatively large and heavy and thus positioned most easily near the floor. Moreover, this relative positioning of the injector and dose calibrator assists in limiting exposure of operating/administering personnel by directing any waves of radiation escaping from the dose calibrator upward to the ceiling of the room. Moving the syringe barrel relative to the syringe plunger in the manner described in the above embodiment facilitates use of commercially available injectors and syringes for use therewith by eliminating the need to change/recalibrate the direction and distance the injector drive member must advance or retract to complete a desired operation.
In another aspect, the present invention provides a method of using a powered injector system to inject a radiopharmaceutical into a body. The method includes the steps of: attaching an extending adapter to the front end of the powered injector; the adapter including an injector attachment to place the adapter in operative connection with the powered injector, the adapter also including a syringe attachment to attach a syringe to the adapter to place the syringe in operative connection with the powered injector; and extending the adapter into a radiation shield. As discussed above, the radiation shield can form part of a dose calibrator to measure the radioactivity of radiopharmaceutical within the syringe. In one embodiment, the exit of the syringe is oriented upward relative to the opposite end of the syringe when the syringe is positioned within the dose calibrator to facilitate purging of air from the syringe. As discussed above, the opening through which the syringe passed to enter the dose calibrator is preferably oriented in a direction (for example, upward toward the ceiling) to decrease the likelihood of exposure of personnel to any radiation waves exiting the dose calibrator during use thereof.
In a further aspect, the present invention provides an adapter for use with a powered injector to attach a syringe to the powered injector including: an injector attachment member to attach the adapter to a powered injector and a syringe attachment member spaced from the injector attachment member by a sufficient distance to position a syringe attached to the syringe attachment member within a radiation dose calibrator. Preferably, the adapter facilitates use of commercially available injector systems with commercially available dose calibrators without the requirement of substantial and/or expensive modification thereto.
In another aspect, the present invention provides an adapter for use with a powered injector to attach a syringe to the powered injector including an injector attachment member to attach the adapter to a powered injector and a plunger extension fixed in position relative to a powered injector. The plunger extension has a plunger attachment member to attach to a plunger of the syringe. The adapter further includes a syringe carriage slidably attached to the adapter and including a syringe attachment member to removably attach a syringe thereto so that a barrel of the syringe can be moved relative to a plunger thereof to control fluid flow into and out of the syringe. As discussed above, the syringe can be oriented with a syringe tip thereof directed toward the powered injector when attached to the syringe attachment member.
In another aspect, an adapter includes an attachment member to removably attach the adapter to a powered injector and a syringe carriage slidably attached to the attachment member. The syringe carriage includes a syringe attachment member to which a syringe can be removably attached. The adapter further includes an end member attached a fixed distance from the attachment member. The end member has a plunger extension attached to the end member and extending toward the injector. The plunger extension includes a plunger attachment member on an end thereof opposite the end attached to the end member. The syringe carriage is adapted to move a barrel of the syringe relative to a plunger of the syringe when a syringe is attached to the syringe attachment member and a plunger thereof is attached to the plunger extension member.
In another aspect, the present invention provides a shield for use with a radiopharmaceutical including a housing that is impenetrable by radioactive energy from the radiopharmaceutical. The shield also includes at least one opening in the housing through which an article containing the radiopharmaceutical, which is positioned within the housing, can be viewed. The opening is in visual alignment with a reflective surface in which a viewer can view a reflection of the article. The opening is positioned within the housing such that there is no direct line between the viewer and the article that is not shielded by a portion of the housing. Because radiation energy from radiopharmaceuticals travels in straight lines, the viewer is shielded from exposure to radiation.
In a further aspect, the present invention provides a method of injecting a radiopharmaceutical into a body. The method includes the steps of: positioning a pressurizing unit or device containing a first volume of the radiopharmaceutical within a dose calibrating unit adapted to measure the level of radioactivity of the radiopharmaceutical; and injecting a second volume of the radiopharmaceutical. The second volume is determined through measurement by the dose calibrating unit to provide a desired level of radioactivity. The second volume can, for example, be less than the first volume. In one embodiment, the pressurizing chamber is a syringe in fluid connection with a powered injector.
In another aspect, the present invention provides a kit for injecting a hazardous pharmaceutical into a body including: a fluid path adapted to connect to a patient; and a fluid delivery set. The fluid delivery set includes a valve assembly to which a pressurizing unit, a source of flushing fluid, the fluid path and a source of the pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set. The valve assembly also preferably provides flow control through the fluid delivery set such that the entire fluid delivery set can be purged of air with the syringe and the source of saline in fluid connection with the valve assembly before the source of pharmaceutical is connected to the fluid delivery set.
In still a further aspect, the present invention provides a method of injecting a radiopharmaceutical into a patient. The method comprises the steps of: connecting a powered pressurizing device that is controlled without intimate or close contact by an operator (for example, remotely controlled, automated or preprogrammed so that the operator is not within a radiation field of a dangerous level) to a valve assembly of a fluid delivery set; connecting at least one source of a flushing fluid to the valve assembly; connecting a patient fluid path to the valve assembly, the patient fluid path terminating in a patient connector; connecting a source of a ready-made (that is, prepared earlier—for example, in an offsite cyclotron) radiopharmaceutical to the valve assembly; and controlling the valve assembly at least during injection of the hazardous pharmaceutical such that operator presence in the vicinity of the radiopharmaceutical is not required. In general, a dose to an individual decreases with the square of the distance from the radiation source. Thus, close operator contact with the pressurizing device, fluid delivery set and other components of the fluid delivery system is not required when the radiopharmaceutical is present in the fluid delivery system. Moreover, shielding as described above can also be used to prevent exposure. The valve assembly can also be controlled without intimate contact by an operator (for example, remotely controlled, automated or preprogrammed).
In general, the present invention provides for administration or delivery of a toxic or hazardous pharmaceuticals (for example, radiopharmaceuticals) in controlled manner to enhance the effectiveness of the pharmaceutical and to enhance patient safety (as compared to current procedures and equipment for delivering such pharmaceuticals), while reducing exposure of administering personnel to the hazardous pharmaceuticals. In general, commercially available injector systems are readily adaptable for use in the present invention without substantial or expensive modification.
As illustrated in
In the embodiment of
A third port 36 of stopcock 30 is in fluid connection with, for example, a dual check valve 50. The flow through stopcock 30 is controlled via control 38. A first port 52 of dual check valve 50 is in fluid connection with syringe 60 that is preferably in operative connection with powered injector 70. A second port 54 of dual check valve 50 is preferably in fluid connection with patient fluid path set 80 that includes, for example, flexible tubing 90 connected to catheter 100. Preferably, patient fluid path set 80 is disposable on a per patient basis to reduce the likelihood of cross-contamination when system 10 is used for injection of fluids into multiple patients. Patient fluid path set 80 is preferably in fluid connection with second port 54 of dual check valve 50 via a one-way check valve 110 to further reduce the likelihood of cross-contamination.
Preferably, saline source 20 is also in fluid connection with fluid path set 80 via bypass tubing or conduit 120 of valve system 16 to provide, for example, flush and KVO (keep vein open) functions on demand without having to adjust control 38 of valve system 16. In the embodiment of
In injection procedures and other fluid delivery operations in which non-hazardous pharmaceuticals are delivered, purging air from the entire fluid path (including, the fluid path between a source of the pharmaceutical and the delivery point) typically includes the forcing an amount of the pharmaceutical through the fluid path to, for example, a waste receptor before beginning the procedure (for example, before insertion of a catheter into the patient). However, in the case of a hazardous pharmaceutical such as a radiopharmaceutical, it is very desirable to minimize or eliminate the creation of waste pharmaceutical. Moreover, as discussed above, it is also preferable in the case of a hazardous pharmaceutical to minimize exposure of administering personnel to the pharmaceutical. The present invention thus preferably enables purging of air from the entirety of fluid delivery set 15 (and preferably, also from patient fluid path set 80) before connection of fluid delivery set 15 to pharmaceutical source 40. In this manner, exposure of administering personnel to hazardous materials during purging is eliminated and no hazardous waste is generated.
After connecting fluid delivery set 15, which is fluid filled and purged of air, to pharmaceutical source 40, air can be introduced into fluid delivery system 10 from pharmaceutical source 40. Thus, precautions are preferably taken as known in the art to reduce the likelihood of introduction of air into system 10 from pharmaceutical source 40. Moreover, a bubble detector 150 can be placed in communication with line 46 to detect if air is drawn from pharmaceutical source 40. Examples of a bubble detector suitable for use in the present invention include the BDF/BDP series ultrasonic air bubble detectors available from Introtek of Edgewood, N.Y.
In the case that it is desirable to purge system 10 (for example, in the case that air is found in one of the fluid path lines), a waste container 161 (which is preferably shielded) is preferably provided. In the embodiment of
During operation of system 10, saline syringe 20 (which can be a hand syringe or a syringe powered by an injector 24) is first filled with saline. Saline syringe 20 is then connected to valve system 16 of fluid delivery set 15 via first port 32 on three-way stopcock 30. Saline syringe 20 is preferably used to purge air from system 10. Saline syringe 20 also provides a flush to patient fluid path set 80 after injection of pharmaceutical(s) to ensure that substantially all the pharmaceutical is injected into the patient and to ensure that very little if any of the toxic or hazardous pharmaceutical remains, for example, within fluid path set 80.
Syringe 60 is attached to injector 70. In the case of injection of a radiopharmaceutical, at least syringe 60 of injector 70 is preferably enclosed within a shielded container during an injection procedure. In one embodiment, the shielded container is a radiation dose calibration unit 200 as discussed in further detail below. Air is first preferably expelled from syringe 60 by advancing plunger 62 of syringe 60 toward syringe tip 64. Syringe 60 is then connected to dual check valve 50 of valve system 16 via first port 52. Patient fluid path set 80 is connected to valve system 16 via one-way check valve 110.
Control 38 is adjusted to place saline syringe 20 in fluid connection with tubing 46. Tubing 46 can, for example, terminate in a spike 48 or other connection member to cooperate with a septum 45 on source 40 (for example, a bottle) as known in the art. A small volume of saline is injected or expelled from saline syringe 20 to purge air from tubing 46 and spike 48. Control 38 is then adjusted to place saline syringe 20 in fluid connection with dual check valve 50. A small volume of saline is expelled to purge flush bypass line 120 of air. Dual check valve 50 provides sufficient resistance to flow such that saline expelled from saline syringe 20 passes through bypass line 120 rather than through dual check valve 50.
Injector 70 is used to retract plunger 62 to draw saline from saline syringe 20. Injector 70 is then used to expel air in line between syringe 60 and catheter 100 by expelling (via advancement of plunger 62) the saline therefrom. At this point, all lines of system 10 are free of air and filled with saline. Syringe 60 is substantially empty except for a small amount of saline not expelled.
At this point, injector syringe 60 is preferably positioned within dose calibrating unit 200 or other radiation containment device in the case of injection of a radiopharmaceutical. Container 44 is opened and pharmaceutical source 40 is spiked to place source 40 in fluid connection with valve system 16. Spiking of pharmaceutical source 40 can be done automatically, remotely or robotically to reduce or prevent exposure of operating personnel. The patient is then connected to patient fluid path set 80 via catheter 100. System 10 is now ready for an injection. The pharmaceutical is drawn into syringe 60 by retraction of plunger 62 relative to syringe tip 64 and then injected into the patient by advancement of plunger 62 relative to syringe tip 64. Saline is then expelled from saline syringe 20, passing through bypass line 120, to flush the pharmaceutical from patient fluid path set 80. All of these functions are accomplished with little on no exposure of the operator or administering personnel to radiation.
In that regard, all adjustments of control 38 were made before the radiopharmaceutical was drawn into fluid delivery set 15. Control 38 can also be adjusted remotely or automatically (for example, via electronic/computer control) in, for example, cases when some pharmaceutical is within fluid delivery set 15 (for example, in a second or subsequent procedure in a case in which fluid delivery set 15 is used for multiple deliveries/injections) to prevent exposure of administering personnel. Other types of valve systems or assemblies, for example, a manifold system, can be used to affect the control of valve assembly 16.
Fluid delivery set 15 is preferably disposable after one or more uses to, for example, reduce the risk of cross-contamination between patients. Fluid delivery set 15, including valve system 16, and/or other components of system 10 can be placed within a protective containment unit 18 during use thereof to further shield personnel from radiation that may emanate from, for example, valve system 16.
In each of containment units 18 and 18 a, one or more mirrored surfaces are used to provide a view of fluid delivery set 15 without creating an unshielded direct line between the viewer and the fluid delivery set 15 (or other radioactive source). There is no need to provide a transparent shield (for example, lead shielded glass) over view ports 162 or 172 because the lack of an unshielded direct line of sight between the viewer and fluid delivery set 15 prevents exposure to radiation. Elimination of leaded glass can be advantageous as such glass is often expensive and heavy and can sometimes diminish or degrade a view.
In the case of injection of a radiopharmaceutical, positioning a pressurizing unit or chamber such as syringe 60 within dose calibrating unit 200 such as the Capintec CRC-15PET dose calibrator available from Capintec, Inc. of Ramsey, N.J., which measures the total radiation of the volume of radiopharmaceutical enclosed within the pressurizing chamber, shields administering personnel from radiation and enables delivery of a known volume of the radiopharmaceutical having a known radiation level (as measured directly by dose calibrating unit 200). The accurate control of injection volume and flow rate provided by powered injector 70 enables automatic injection of a calculated volume of fluid (using for example processing unit 71 of injector 70) that will provide the level of radiation necessary, for example, for a PET or SPECT image given the measured radiation of the total volume of radiopharmaceutical contained within syringe 60 provided by dose calibration unit 200. Thus, it is no longer necessary to calculate and wait for the precise moment in time when radioactive decay has brought the level of radiation of a volume of radiopharmaceutical to the desired level, thereby saving time and reducing the complexity of the injection procedure.
In the embodiment of
Injector head 72 is oriented in a generally vertical, downward direction on slide bar 220 to position syringe 60 within dose calibrating unit 200. To ensure that air is purged from a syringe, however, injector heads are typically positioned such that the exit, or tip, of the syringe is oriented upward during purging. As air is less dense than other injection media and saline flushes, the air rises to the syringe tip or exit and is readily purged by, for example, forcing a small amount of fluid from the syringe. To enable a generally vertical orientation of syringe 60 with syringe tip 64 oriented upward in the present invention, a syringe adapter 400 was used.
Syringe adapter 400 attaches to injector 70 in preferably the same manner as syringes are attached thereto. Attachment adapters can be used as known in the art to facilitate such attachment. Adapter 400 can, for example, be removably attached to injector 70 via flanges 412 on an attachment member 410 that cooperate with retaining slots in injector 70 (not shown) as described in U.S. Pat. No. 5,383,858, assigned to the assignee of the present invention, the disclosure of which is incorporated herein by reference.
Adapter 400 includes a drive extension 420 that removably connects to drive member 79 of injector 70 via an attachment member 430 that can, for example, include capture members that cooperate with a drive member flange 79′. Drive extension 420 attaches to a syringe carriage 440 at an upper plate member 442 of syringe carriage 440. Syringe carriage 440 is slidably disposed upon adapter 400 via slide bars 450 a and 450 b that extend from the rear surface of attachment member 410 to a fixed, lower base 460. Syringe carriage 440 includes a syringe attachment member 444 attached to a lower plate member 446 of syringe carriage 440. Upper plate member 442 and lower plate member 446 are connected via connecting members 448 (for example, metal or plastic bars). Syringe attachment member 444 can include slots (not shown) that cooperate with flanges 66 on a rear portion of syringe 60 to removably attach syringe 60 to syringe carriage 440 as illustrated in
Adapter 400 further includes a plunger extension 470 that includes a plunger attachment including, for example, a flange 474 that cooperates with capture members 63 on the rear of plunger 62 to removably connect plunger extension 470 to plunger 62. Adapters as known in the art can facilitate connection of plunger extension 470 to various plungers. Plunger extension 470 maintains plunger 62 in a fixed position relative to base 1o 460 and injector head 72. By upward and downward movement of syringe carriage 440 (via injector drive member 79 and drive extension 420), the position of plunger 62 within syringe 60 is changed. For example, advancing drive member 79 causes the barrel of syringe 60 to move downward and causes a corresponding or relative advancement of plunger 62 toward syringe tip 64, thereby causing fluid to be expelled from syringe 60. Upward movement (or retraction) of drive member 79 causes the barrel of syringe 60 to move upward and corresponds to retraction of plunger 62 relative to syringe tip 64, thereby drawing fluid into syringe 60.
An extending syringe adapter, such as adapter 400, enables use of commercially available injector systems and commercially available dose calibrators in the system of the present invention without substantial modification. The use of adapter 400 is transparent to the injector control software/hardware as no change and/or recalibration of the controlled movement of drive member 79 of injector 70 is required.
Although the present invention has been described in detail in connection with the above examples, it is to be understood that such detail is solely for that purpose and that variations can be made by those skilled in the art without departing from the spirit of the invention except as it may be limited by the following claims.
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|Dell Mary A
|Delivery methods, systems and components for use with radiopharmaceutical substances
|Jun 11, 2009
|Dec 9, 2010
|Bracco Diagnostics Inc.
|Infusion system configurations
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Jul 16, 2004
Owner name: MEDRAD, INC., PENNSYLVANIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:REILLY, DAVID M.;HIRSCHMAN, ALAN D.;GRIFFITHS, DAVID M.;AND OTHERS;REEL/FRAME:015589/0769
Effective date: 20020724
|Apr 1, 2008
|Certificate of correction
|Oct 18, 2010
|Fee payment
Year of fee payment: 4
|Feb 11, 2014
Effective date: 20131107
Free format text: CHANGE OF NAME;ASSIGNOR:MEDRAD, INC.;REEL/FRAME:032250/0165
Owner name: BAYER MEDICAL CARE INC., PENNSYLVANIA
|Oct 17, 2014
|Fee payment
Year of fee payment: 8


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All hotels in Plainfield, Connecticut, United States of America
1 room, 2 adults
55 Lathrop Rd, Plainfield, CT, 06374, United States of America, 855-239-9223
Quality Inn Plainfield, Plainfield
Lowest price$80
Best Price Guarantee
The property is undergoing renovations. The following areas are affected:
The following facilities are closed until further notice:
During renovations, the hotel will make every effort to minimize noise and disturbance.
- Swimming pool
The following facilities are closed until further notice:
- Swimming pool
During renovations, the hotel will make every effort to minimize noise and disturbance.
No-frills Plainfield hotel with outdoor pool
- Free continental breakfast, free WiFi, and free parking
When visiting Plainfield, Quality Inn Plainfield is a great choice to consider. Guests can visit the fitness center for a workout or splash around at the outdoor pool or seasonal outdoor pool.
Main amenities
- 49 guestrooms
- Outdoor pool
- Fitness center
- Business center
- 24-hour front desk
- Air conditioning
- Laundry service
- Meeting room
- Barbecue grills
- Luggage storage
What's around
- Prudence Crandall Museum (5.2 mi / 8.4 km)
- Old Furnace State Park (9.6 mi / 15.5 km)
- Davis Park (11 mi / 17.7 km)
- Dalice Elizabeth Winery (11.4 mi / 18.4 km)
- Preston Highway Park (11.6 mi / 18.7 km)
Hospitality was great but the renovations makes the stay a bit comfortable. Room itself…
Excellent customer service! Excellent wifi service. The best TV Channel choices than any…
TripAdvisor Traveller Rating: 3.5
From 15 reviews
Enter dates to check prices
Hotel Info: 866-539-8117from $80
- Standard Room, 1 King Bed with Sofabed, Smoking
- Standard Room, 1 King Bed with Sofabed, Non Smoking
- Standard Room, 1 King Bed with Sofabed, Smoking
- Standard Room, 2 Queen Beds, Smoking
- Standard Room, 2 Queen Beds, Non Smoking
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 49 rooms
- Check-in time starts at 3 PM
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed *
- 2 per room (up to 20 lb)
- Free WiFi and wired Internet access in public areas
- Free WiFi in rooms
- Free self parking
Nearby Two Star Plainfield hotels
In the hotel
Food and drink
- Free continental breakfast daily
- Barbeque grills
Things to do
- Outdoor seasonal pool
- Outdoor pool
- Fitness facilities
Working away
- Business center
- One meeting room
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Luggage storage
- Elevator/lift
In the room
Home comforts
- Climate control
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
Freshen up
- Hair dryer
Be entertained
- Satellite TV channels
Stay connected
- Free newspaper
- Free WiFi
- Phone
Top Plainfield hotels
Recently reviewed hotels in Plainfield
- Clarion InnFrom
- Crowne Plaza Providence-Warwick AirportFrom
"Awesome service from check in to check out... We got such a great rate, especially for a Friday night stay over. Hotel is beautiful and the bed and pillows were both SO comfy!!…"Sep 3, 2015
- Point 1 MotelFrom
"The staff were very friendly and helpful!"Sep 3, 2015
- Best Western Airport InnFrom
Nearby hotels
Quality Inn Plainfield, Plainfield's small print
Also known as
- Plainfield Quality Inn
- Quality Inn Plainfield
- Quality Plainfield
- Quality Inn Plainfield Hotel Plainfield
Optional extras
Pets are allowed for an extra charge of USD 10.00 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.

subset: commoncrawl


text:
Select indicator
Australia Coal exports, thousand short tons: For that indicator, The U.S. Energy Information Administration provides data for Australia from 1980 to 2012. The average value for Australia during that period was 174972.35 thousand short tons with a minumum of 47711.34 thousand short tons in 1980 and a maximum of 332363.41 thousand short tons in 2012.
Oil prices outlook: take part in our forecast survey. Coal exports rankings around the world. Create and download charts for Australia Coal exports and other indicators with the country comparator.


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Browse More Listings in Industrial For Sale, Murfreesboro, TN or Tennessee
Office/Distribution Facility, Excellent Condition. 28.9 acres. Plat for 12 commercial lots on rear parcel. Origional 50,000 sq ft built in 1956 (Renovated), 31,958 Built 1998101 Parking spaces19,403 sq ft Office20,798 sq ft Warehouse 28' ceilingsOffice furnishing negotiable.41,757 sq ft Warehouse 15' ceilings
South on Murfreesboro Road/Broad towards Murfreesboro, Singer Road on right before 840 exchange. Four miles from Nissan Facility, 1/2 mile from 840.
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Hotel Susy
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
Travelers also recommend:
TripAdvisor Reviews Hotel Susy Rimini
Travel Blogs from Rimini
Pesaro - Cesenatico
... using the free WiFi and it was reported to be only 30' with 70% humidity - it was a hell of a lot hotter than that. My Garmin will have the temp so will check that when I'm able to upload - we need WiFi for that.
The final water break was at 50km. We had decided that we would pull the pin after 60km today due to the heat and the time. We didn't make as good as progress as yesterday - dunno why? The cold fizzy water went down well. It was ...
Split - Ancona - Pesaro
Hello from the East Coast of Italy. Did I say it was hot yesterday? Well, it is hot again today. I should have saved the hot, damn hot for today as it was bloody hot! Especially on the bike on the bitumen.
We started the day at sea somewhere between Split in Croatia and Ancona in Italy. The boat was due in port at around 7:00am. We ducked down to grab some breakfast in the cafe. Placed our order and wanted to pay using the travel card. ...
Venice to San Marino - Travel day
Venice morning was another spin around the canals and then a little shopping. Even at the H&M sales. We then caught the slow boat to China - actually the ferry from the top of the main canal to the bus station (45 mins with all the stops) to meet Lee who was waiting to meet us with our black Opal station wagon hire car. We drove to San Marino and caught the cable car up to the top. We had visited here with Erwin and Di and loved ...
Leaving Riccione
Today I am going to be sad to leave Riccione but today I'm going to have eighteen coins for the Sala giochi and I am trying to get as much tickets as I can so that I can buy a Mqueen bag for my cousin Oliver. when I arriv e in Issenheim I'll be happy to hop back on my skateboard and have some fun over ...
A new goal
Today at the Sala de giochi I decided to have a new goal. I know that I will not achieve this goal so I might not work on it very much tomorrow. This goal is to buy a McQueen bag for my cousin Oliver. Tomorrow I am not sure what I will play. I did play a new game were you have to try and shoot moose. Other than that it was a normal day. There is a photo below showing how hot it ...


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Saturn Ion Commercial 2
2007 Saturn Ion Coolant Light
In this video, We will show you one way to troubleshoot the Coolant Alert or a coolant light on most Saturns. This is a common issue and creates a bit of confusion or trouble. If temps are still somewhat reading, and you have this alert, typically here is the cause. Shoutout to the ShoRyders in Tucson, celebrating their annual coming up this weekend. BE THERE.
turbo saturn vs. supra
4-door turbo saturn vs. supra
Quick Saturn Ion Review
Big thanks to my friend Chris for lending me his beautiful Saturn Ion Redline for my first unofficial review video Had to make this review short and sweet. Next review coming soon... And here's a hint.. 600HP...


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Albergaria Insulana
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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TripAdvisor Reviews Albergaria Insulana Lisbon
Travel Blogs from Lisbon
Onto Lisbon
We travelled to Lisbon in the afternoon on a 2 hour flight. Looks to be quite nice!
Aug. 6 - we were one our own today so just did some walking around, and damn! We found a wine store!
Aug. 7 - we had a city tour today that took us all over, ending up in the old town area where we had free time to wander around. Beginning to think I liked Barcelona better!
Beer, pick pockets, and embarrassing moments
... become a bit complacent!
And so it wasn't until 6.30pm that we called Jorge to meet us to open up the unit at Peniche where we would stay for the next few days.
The unit was cute and overlooking the ocean which would be home for the next 3 days. Sadly the bathroom was only a slightly bigger shoebox than that of Iceland and the lack of a shower head meant the water splashed all over the plastic curtain and then onto the floor.
The toilet was almost ...
Short but sweet
... alley (dark, mysterious and hidden). Additionally (it gets better), whoever is familiar with Sirius Black's house will appreciate this... I was shown two Catholic Churches next to each other. Now it's been the law for centuries that no two Catholic Churches are allowed to touch. In actual fact they weren't, there was a long skinny house between them. Now, Sirius Black's house is not visible to muggles and is a long, skinny, mysterious house. Yep. I was mind ...
Lovely Lisbon
... the castle grounds). After the castle exploration we wandered through the streets of the Alfama and eventually made it back down the the river just in time for a short but very vigorous rain shower. Good thing we packed our ponchos as Craig's umbrella immediately disintegrated upon its very first opening!
We eventually make our way over to the Praca do Comercio dominated by the Arch of Triumph and headed back towards the hostel by walking up Rua Augusta ...
Lisbon Adventures
... towers in the park I heard a little girl beside me say "This is so much better than that time we went to Disneyland"!! You know it must be a pretty special place when you hear that. The majority of the features here were built in the early 1900's and has been owned over the years by a series of increasingly wealthy private citizens. The huge wells and spiral staircases, stepping stones across lakes and under bridges, the underground tunnels, some ...


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22-9362 - Leak Alert - electronic water detector
Protect your home from water damage with Leak Alert™!
Place Leak Alert anywhere there is a danger of flood or leaks, near water heaters, sinks, dishwashers, or sump pumps.
Leak Alert sounds a very loud alarm when it gets wet, and keeps sounding the alarm for ...
Mfr Name: Zircon
Mfr Number: 042186850086
See all items in Water Detectors
105-695 - T+ Pro Electrical Tester
The Fluke T+PRO is the ideal, full-featured tester for the demanding commercial and industrial electrician. It has all of the advantages of a traditional solenoid tester, with added functionality, but none of the typical drawbacks. With voltage measurement, contin...
Mfr Name: Fluke
Mfr Number: T+PRO
See all items in Voltage Testers/Detectors
82-14505 - Covert Smoke Detector CCD Camera
Smoke detectors are great for hidden surveillance because every residence/business has them. This model replicates a real functioning smoke detector while providing high resolution video through its peephole lens.
Mfr Name: Defender Security
Mfr Number: 82-14505
See all items in Dome Cameras
294-1950 - Long Life 9V Lithium Cell Battery
Ultralife 9V lithium battery lasts up to 10 years. Ideal for smoke detectors, garage door openers, clocks, radios, remote control toys or any device that needs a high quality 9V battery.
UL listed
Made in USA
Single pack
Mfr Name: Ultralife Batteries
Mfr Number: LITH-9V
See all items in 9V Batteries
22-11355 - Voltage Tester with Polarity and Continuity Check
This screwdriver type voltage tester is used to test DC voltages up to 250V and AC voltages from 70V~600V Also measures continuity from 0~50MR.
Mfr Name: Duratool
Mfr Number: IN01716
See all items in AC Voltage Detectors
72-10385 - Non Contact AC Voltage Detector Pen 90V~1KVAC with Vibrating Alert
Non Contact AC Voltage Detector with Vibrating Alert
The easy to use AC Voltage Detector provides site, sound, and vibration indication for added safety in even bright or noisy environments. Flashing, beeper, and vibrating indicators to alert use of AC voltage.
Mfr Name: Tenma
Mfr Number: 72-10385
22-9356 - Breaker ID Circuit Breaker Finder
Now one person can find the right circuit breaker before turning off power to one specific circuit.
Just plug the Breaker ID's transmitter into the electrical outlet, then scan the breaker box with the receiver, and the proper breaker will be identified.
You w...
Mfr Number: 042186589856
See all items in Circuit / Outlet Finders & Testers
80-1195 - AM/FM Radio Kit
Build your own AM/FM radio. Kit includes: 115/8" x 51/4" PC board, 52 page manual divided into nine lessons; audio amplifier, AM detector, AM IF, AM amplifier, AM mixer and oscillator, FM detector, first FM IF, second FM IF&...
Mfr Name: Elenco
Mfr Number: AMFM-108CK
See all items in Project Labs
72-9165 - Environmental Tester Digital Multi Meter
Feature loaded DMM includes multiple environmental testing functions replacing 6 testers. Includes light meter, sound level meter, hygrometer, thermometer, non-contact voltage detector and multi-function multimeter.
Mfr Number: 72-9165
See all items in Handheld
22-2000 - E-Z Check Plus GFI Circuit Tester
The E-Z Check® plus GFI circuit tester checks for the following conditions: Correct wiring, open ground, reverse polarity, open hot, open neutral, hot on neutral, hot and ground reversed with open hot, and ground fault interruption...
Mfr Name: Ideal
Mfr Number: 61-051
105-745 - VoltAlert™ 90-1000V AC Volt Detector
Always-on, easy to use voltage detector is ideal for use at home or for commercial use. This non-contact voltage detector detects voltage from 90V to 1000V AC. Tip glows red when voltage is present.
Mfr Number: FLK2AC/90-1000V
28-11126 - Thermal Leak Detector Energy Saver
Black & Decker's Thermal Leak Detector helps reduce energy costs by finding energy leaks in your home.
You'll instantly identify problem areas around drafty windows and doors, and uncover hidden leaks and insulation "soft spots" around electrical outlets, reces...
Mfr Name: Black & Decker
Mfr Number: TLD100
See all items in Infrared Thermometer
72-9180 - AC/DC Clamp Meter Leads
Use almost any DMM as a clamp meter for current testing up to 400 Amps Current displays as an easily translated voltage reading
Mfr Number: 72-9180
See all items in Clamp Meters
72-8765 - Volatage Detector
This detector is ideal for electricians, maintenance staffs, service and safety personnel and homeowners. It can detect voltages from 90V to 1000V AC. Built in LED light brightens work space in dark areas. Red LED light and audible alarm if voltage is present.
Mfr Name: Pro'skit
Mfr Number: NT-306
72-11315 - Non-Contact Voltage Tester
Provides detection of voltage in cables, cords, circuits, light fixtures, switches and outlets safely without making contact. A high intensity, bright green LED indicates the tester is operational and aids in illuminating the workspace. When voltage is detected,...
Mfr Name: Klein Tools
Mfr Number: NCVT-1SEN
I have used MCM for many years and would give high recommendation for getting the job done right.


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Select Local Merchants
Cactus LoungeRead MoreCactus Lounge is serving up American favorites with a tasty tweak. Calories take a backseat at Cactus Lounge, where low-fat anything is barred from the menu. Cactus Lounge is located near endless parking options, allowing diners to find quick and easy parking. Treating yourself doesn't mean breaking the bank, come taste the great dishes Cactus Lounge has to offer.3711 W Main StGray, LA US
HootersRead MoreLocated in Houma on Martin Luther King Jr Blvd, Hooters is a well-known restaurant that delivers flavorsome burgers and tasty burgers. An unforgettable dining experience set in a laid-back vibe. It's a culinary destination for guests interested in outstanding food. Defined by its outdoor seating, the restaurant is a fantastic option when the weather is suitable. There's no particular required attire, so feel free to dress comfortably. Also, it's often reported that the background noise can get a little loud here. It's a good option for families with children, large groups, and dancing. WiFi's available if you want to link your device up, and in addition to its convenient take-out menu, the restaurant even provides catering for events around town. Or, if you're looking for the perfect spot to unwind after work, it's got a phenomenal happy hour and a pretty stout selection behind the bar. One of the tastier franchises in the area, a trip to this Hooters is definitely worthwhile. Don't worry about trying to find a spot on the street, as visitors to the restaurant do have access to a private parking lot nearby. Would you rather ride there? Bicycle parking is also provided.1619 Martin Luther King Jr BlvdHouma, LA US
Buffalo Wild WingsRead MoreWhether you love them dunked in ranch dressing or smothered in barbecue sauce, the wings at Houma's Buffalo Wild Wings will fit any taste. Buffalo Wild Wings is making food that everyone loves. Taking it back to the high-calorie basics. Toast your evening out at Buffalo Wild Wings with a glass of beer or wine from their lengthy drink list. Families will feel right at home at Buffalo Wild Wings with its kid-friendly menu and atmosphere. Shake off your workday and treat yourself to Buffalo Wild Wings' happy hour. When the weather is nice, hurry to Buffalo Wild Wings to grab a spot on the patio. Don't go off the grid! With the free wifi at Buffalo Wild Wings, you can surf the web and get some work done. Volume at this restaurant can reach upper decibels, so come prepared to raise your voice to be heard. Business casual dress, tasty food and a classic atmosphere makes this a great place for any occasion. If you're strapped for time, take out food from Buffalo Wild Wings. For the tastes of Buffalo Wild Wings from the comfort of your next party, the restaurant also offers catering services. null Prices are affordable, with a typical meal running under $30.1783 Martin Luther King Jr BlvdHouma, LA US
Downtown BalconyRead MoreFor bar nibbles and pub food par excellence, Downtown Balcony is a top pick. Health-crazed eaters may have to stick with water, though, as Downtown Balcony offers delicious grub that's far as can be from low-fat fare. Parties of any size can easily be seated at Downtown Balcony. Jeans are just right for a meal at Downtown Balcony, which embraces a casual vibe. Downtown Balcony patrons can find street parking at the Main St location. It's not the cheapest, it's not the most expensive, but it is the most delicious. Come to Downtown Balcony for a great bite. Downtown Balcony offers a wide variety of payment options, including payment by major credit card.7834 West Main StreetHouma, LA US
Dooley's NightclubRead MoreCraving finger food? Head to Dooley's Nightclub and chow down on classic pub fare. Dooley's Nightclub is creating dishes that might not be low in calories, but they certainly won't be low in flavor. Dooley's Nightclub is completely informal — dress as you see fit (and are most comfortable). Tired of driving in circles? Head to Dooley's Nightclub for a bite to eat and find quick parking in the lot next door. Dooley's Nightclub's fare is so good, you'll want to sample everything on the menu (and with its middle-of-the-road prices, you can!).1548 Barrow StHouma, LA US
The Boxer and the BarrelRead MoreSwing by The Boxer and the Barrel in Houma for your next meal. For music and dancing, The Boxer and the Barrel also features live bands and an open floor. Between the music and the crowds, be prepared for a lot of noise at this restaurant. Weekend diners, beware! The restaurant is busiest on Friday and Saturday, so getting seated will take some time. Drivers can find a space for their wheels on the street when dining at the restaurant's Main St business. Travel by bike to The Boxer and the Barrel and store your bike at a nearby rack.7817 Main StHouma, LA US


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In revival modeThewa is my middle name, says Roopa Vohra, the Mumbai-based jewellery designer who resuscitated the dying Mughal craft in the 1990s. Thewa involves embossing intricately worked-out sheet gold on molten glass of varied hues. The result is a stunning ... Outlookbusiness.com, 2 months ago
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Get More Bang for Your Food Buck Video
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Watch Liverpool flop show Rodgers what he's missing with insane goal
Incredible effort.
Crazy! Balotelli given a bizarre list of behavioural rules at AC Milan
Do AC Milan really think this will work?
'I have a lot of motivation' - controversial Liverpool striker talks up latest transfer move
Can Balotelli turn his career around?
See ya! Balotelli pictured arriving for AC Milan medical ahead of quick Liverpool exit
Liverpool are paying part of his salary to get him out of the club ASAP.
Tottenham 'ready to sign incredible perfect free-kick taker after asks for transfer'
Tottenham and Everton have been put on red alert.
The greatest goal of all time? Watch Philippe Mexes' stunning strike against Inter Milan
Absolutely incredible.
Arsenal 'transfer target Mattia Destro set for summer move away from AC Milan'
He'd be a great addition to Wenger's attacking options.
AC Milan Under-10 players 'racially abused by parents on touchlines' during match v Paris Saint Germain
An officially investigation has been launched into the incident.
Agent of Arsenal transfer target Stephan El Shaarawy CONFIRMS bids for AC Milan forward
The Italy international was the subject of interest in January.
AC Milan 'to rival Liverpool in transfer race for Borussia Dortmund star Ciro Immobile'
The Reds have seemingly suffered a transfer blow with Milan offering the Italian a route home.
Fiorentina and AC Milan start playing without a referee on the pitch
Italian football really is bad these days...
Arsenal target Stephan El Shaarawy 'pleased' Gunners are interested in a potential transfer
Move to the Emirates on the cards?
Former AC Milan manager Arrigo Sacchi says there are 'too many blacks' in Italian football
Sacchi has since claimed his quotes have been 'misinterpreted'.
AC Milan to battle Arsenal and Liverpool for Manchester City's James Milner
Life could get a little less boring for James Milner...
Mario Rui kicks ball into his own face – and WINS Empoil a free-kick during draw at AC Milan
It is no wonder AC Milan failed to be beat Empoli this afternoon when the referee was handing out cheap free-kicks like this one. The match official awarded the visitor's a set-piece when left-back Mario Rui kicked the ball into his own face. Admittedly, the Portuguese player's theatricals following the incident probably helped his team […]
AC Milan unveil striking images of a proposed new home – yet it is almost half the size of the San Siro
Images of an all-singing, all-dancing 48,000 capacity have been released.
Philippe Mexes gets sent off for grabbing Lazio captain Stefano Mauri's throat during AC Milan defeat
The defender suffered a major moment of madness during his team's 3-1 loss.
Suso fires parting shot at Liverpool following AC Milan switch
Former midfielder pans the club over a lack of trust in his ability
AC Milan make two additional walls for Jeremy Menez's bizarre free-kick
This is certainly a new one...
Fernando Torres leaving Chelsea for AC Milan is a relief for the Blues
The Spaniard now has the chance to find his form again.


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|Soft, fluffy cute bear. The gentle touch of "baby alpaca" further UP for cuteness! Loveliness would want to keep near at any time!
|Use the flip, so that mokemoke is on the other side of the fabric.
[678] nimes (Nimes)
Col.03 1 ball (20 g).
(Brackets is the amount actually used)
[303] fine Merino
Col.203 a (small) 1 ball
(Brackets is the amount actually used)
|KeyHand 6 / 0 no.
|[A-318-300] sewing cottonThe Brown yarn, glue,
[H221-304-1] is cumbersome (4 mm) black (6 pieces) 2 pieces
The weaveClick here for
* May seem images visual environment at filming, monitor settings, and personal differences for other reasons, real colors vary.
This product cannot be shipped to United States from the store.
Please contact the store for further information.


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JUNIOR (2014)Missed first three games with an injury before playing in six of the final seven contests on special teams ... lone tackle of the season came on a kickoff coverage at Columbia.
SOPHOMORE (2013)Sat out the season with an injury.
FRESHMAN (2012)Spent the year developing on the junior varsity squad ... made tackles in each of the three jayvee games, including six stops in the finale against Bridgton Academy.
HIGH SCHOOLThree-year starter who captained the Lutheran football team as a senior ... also played wide receiver for the Lancers ... seven teammates signed letters of intent to play college football including at Navy, UCLA, Nevada and Montana ... four-year scholar-athlete in football for Lutheran ... runs 100 and 200 meters in spring track ... featured in a lengthy Esquire Magazine article about former NFL quarterback Todd Marinovich.
PERSONALHistory major ... full name is Jordan Connor Greenwood ... born on Dec. 8, 1993 ... son of Scott and Andrena Greenwood has one brother ... enjoys rock climbing ... rides motorcycles.