text:
Routine maintenance continues for the bridges that
are accessible. Political turmoil still makes it difficult to reach many sites. EcoSystems is not the only group to be affected--the entire city of Kathmandu is short of fuel while the road links with India are blocked. Discussions are under way for site surveys in
several parts of the country. A new 'hanger' design will be tested in one of the long bridges shortly, as part of the ongoing program to further improve the service life of the bearings.
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
If you donate to this project or have donated to this project, you will get an e-mail when this project posts a report. You can also subscribe for reports via e-mail without donating or by subscribing to this project's RSS feed.
Thanks to 59 donors like you, a total of $4,506 was raised for this project on GlobalGiving.
Combined with other sources of funding, this project raised enough money to fund the outlined activities and is no longer accepting donations.
Still want to help?
Support another project run by VillageTech Solutions (VTS) that needs your help, such as:
Menlo Park,
United States
Managing Director
Menlo Park,
United States


text:
Sheila Brosnan's Profile
I am a Toronto based Artist specializing in Pet Portraits. I am a graduate of the Ontario College of Art and Design and University of Guelph's Fine Art program. After several years of working as a Behaviour Specialist in Toronto's neediest inner city schools, I turned back to painting as a theraputic release from this stressful and often heartbreaking work. Painting animals was a natural starting point for me. I soon found that my paintings were not only keeping me happy, but they were also bringing smiles to the faces of others. This is how I now measure the success of each painting; does it make us smile? With this in mind, I began painting portraits of pets for my friends and family, after all, what makes us feel better than the sweet faces of our beloved pets? This past time has now become a full time business that I run from my home in Toronto (with the assistance of my cat, Gary, pictured in the banner above).
- Female
- Joined September 11, 2012
- Sheila Brosnan
- Toronto, ON, Canada

subset: commoncrawl


text:
Vince Wilfork on the interactive hunt for his 'missing' Super Bowl ring: ''It's a fun way to get the fans involved.'' - 0 Comments
Patriots nose tackle Vince Wilfork was just on the "Toucher & Rich" show on 98.5 the SportsHub talking about the new promotion and interactive game fans can play on their iPhones or Android devices.
If you go to Patriots.com, you'll find a video and "Help Vince" game inspired for fans to help Wilfork locate his missing Super Bowl ring, presumed to be taken by a nefarious-looking Jets fan holding it for ransom.


text:
Quit Smoking Now with Max Kirsten
By Craig Ray
Open iTunes to buy and download apps.
'Quit Smoking Now with Max Kirsten' App has been listed in the 2013 and 2012 Sunday Times "THE APPS LIST - The Worlds Best Apps". Voted #1 Stop Smoking New Years Resolution iPhone App - "The Top 5 New Years Resolution iPhone Apps" The iPhone App Review - "I gave up smoking with the help of Max Kirsten's Quit Smoking download, and so can you. " Ewan McGregor (Actor).
"Still not smoking, but best of all no desire to. Not even in trigger situations. And no unwanted weight gain! Weh hey!! Thank you"
Andrea (Ex 40 a day smoker - USA)
"Hi Max Don't know if you remember me, but just to let you know that last Sunday marked two years without a single cigarette. Thanks again!"
Geoff (Ex 50 a day smoker - UK)
"In only 60 minutes I quickly and easily stopped smoking without cravings, anxiety or weight gain. This program helped me kick the habit… Without any suffering"
Sandra (Ex 40 a day smoker - UK)
Max Kirsten became The Times Newspaper's leading 'self-help' expert writing a special 5-day series on 'How to survive the effects of anxiety after the world's financial meltdown' including a series of specially created Times hypnotic podcasts.
Max Kirsten is an internationally renowned and highly qualified clinical hypnotherapist - with many one to one clients, including film stars, politicians and business leaders.
After helping 1000's of people successfully stop smoking, Max Kirsten brings his famous 'Quit Smoking Now' program to the iPhone and iPod Touch.
This is a proven quit smoking program - not a generic hypnosis product.
What's included:
- Introduction video
- High quality recordings with binaural beat technology
- Getting started session
- Main Quit Smoking Now session
- Booster Session
- Quit Smoking e-book and guide
- Smoking Fact Cards
- Smoking Calculator
- Video testimonial from Ewan McGregor
So for around the cost of a packet of cigarettes, you too can now take advantage of this successful and highly effective quit smoking program.
Find out more about this application at:
You can read some more of his success stories and testimonials on his website at:
iPhone Screenshot
Customer Reviews
Amazing app. Working for me
Non-smoker for 31 days now. I used to be a heavy 30+ a day smoker. This app has helped me so much and I am so grateful. I didn't really believe an app would help me to quit smoking. I read all the testimonials on here and hoped it might help a bit. The first quit day I chose didn't work out - I ended up smoking, after being agitated all day without a cigarette.
Not to be defeated, I listened to the main session for the next 2 consecutive nights then decided to try again. I also read the book Never Take Another Puff by Joel Spitzer. I smoked my last cigarette at 10:45 pm and listened to the main session right after. I woke up the next morning without my usual, frantic, desperate need for a cigarette first thing - I was surprisingly calm and didn't have that mad panic to light up before doing anything else. This has never happened before, a cigarette is the first thing I think of and had to have a soon as I was awake.
I drank cranberry juice for the first 3 days, as it is very acidic and helps the body eliminate nicotine faster. I did have mild crave times (surprisingly not as strong or as frequent as in the past) but these passed by quickly and I used the 3 breath technique when they persisted. I still listen to the main session twice a week and the booster session on the other days. Thank you so much Max, this app has changed my life.
It must work in some way!
Until may 09, I was a 30 a day roll up smoker and had been for 10 years (I am 28) and on my own I cut down to about 15 a day in may. My wife quit cold turkey back in march 09, so she has wanted me to quit, so come january the 1st I thought why not give it a go and bought this app. The two previous times i tried to quit, I managed to the early evening and cracked! New years day 2010, i did the session and have been smoke free ever since! Amazing! I have done the session once more since. I had to quit because my grandad died at 61 of lung cancer and I don't want to obviously! I love smoking and always will, we have done it for thousands of years and will continue to, but something in this app changes you, i mean I still want to smoke, but something is stopping me. It is hard to describe. He just tells you the usual stuff in the session 'smoking makes you stink' and 'is bad for health' I was almost laughing while hypnotised! But all credit to him, it works! You will not be disappointed!
One happy wife!
Every year for the past who knows how many years I am forced to put "stop smoking" in my new year resolutions and every year my wife gets me something "to help". Patches, gum, etc (she got me patches and gum this year). Every year I start on it with good intentions and stick to it for 5-10 days (this year I lit up again on the 9th so not a record setting year!). But my mate got this app and swears by it and after he'd been smokeless for 2 weeks he persuaded me to try it. Now it's only day 7 but I haven't felt like lighting up at all yet. Normally I'm driving people up the wall by now but my wife is being so nice to me it's hard to think of going back to it! Thanks Max for whatever rewiring of my brain this app did - it seems to be working. The wife sends lots of hugs and kisses (she's made me type that!). Now if you just had a lose weight one for the wife (Ouch!)...
- £4.99
- Category: Medical
- Released: 16 November 2008
- Version: 1
- Size: 111 MB
- Language: English
- Developer: Craig Ray
- © 2008 Origin Creative
Compatibility: Requires iOS 2.0 or later. Compatible with iPhone, iPad, and iPod touch.


text:
You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
Couldn't resist "Shine for You" Greg. What a romantic jewel. All the best from LA.
You Are My Song...beautiful. Your friends.
Re stress heart is relaxing and very well balanced in regards to composition. Nice voice. Wayne
Greetings from Las Vegas!
supporting independent music, great job!
God Bless James
Great work!!
Outstanding \m/ \m/
i like your music - awesome made**
Somewhere in My Heart. is great tune! On my playlist for the weekend. Thanks for sharing.
Love your music!
I really love your sound! I am a fan as well as artist. Keep up the good work! -Jarra


text:
Welcome to Murray Independent
The Murray Independent School District website is your official source of information about our district, our schools, and our students. We work hard daily to uphold the long tradition of academic excellence that has been in existence since 1872. We provide a quality education in a safe and caring family-like environment.
We were among the first schools in West Kentucky to be fully accredited by the Southern Association, the first in Kentucky to have Drivers' Education, we were the leader with Head Start, the first in this area to move toward the innovative middle school concept, the first to have a national championship marching band, the first to be a nationally honored secondary school, and the list goes on.
Robert Frost said, "Home is the place, when you have to go there, they have to take you in." We like to think of our schools as the place, where, if you get to go there, you know they'll take you in. It's the place of fond memories and strong ties. Theologians may speak of the Trinity and World War II historians of the Big Three. We think our community has been shaped by three also ... the families, the churches, and this school district.
- Employment Information
- Open Bids and Requests for Proposals
- Financial Information
- Emergency Parent Notification System
- Restraint & Seclusion Information
- Murray High School Recognized as Ntl. Blue Ribbon School
One of Four Kentucky Public Schools
- Murray High Swim Team
Any student in grades 7 and 8 interested in competing for the Murray High School Swim Team should attend and informational meeting on Friday, October 2, at 3:30 PM in the Murray High School Library.
- MHS Homecoming and All Class Reunion
Friday Night Sept. 18
- MISD Monthly Financial Report - August 2015
MISD Monthly Financial Report - August 2015
- August SBDM MInutes
August 11, 2015 SBDM Minutes


text:
Diane Keaton Regrets Pushing for Marriage With Al Pacino
- Photo: WireImage.com1 of 12
- Photo: Doug Meszler/Splash News2 of 12
- Photo: REED SAXON/Invision/AP3 of 12
- Photo: Splash News/Splash News4 of 12
- Photo: starsurf / Splash News/Splash News5 of 12
- Photo: Gregg DeGuire/WireImage.com6 of 12
- Photo: London Entertainment/Splash News7 of 12
- Photo: London Ent/Splash News8 of 12
- Photo: Everett Collection/Rex Feaures/MSN9 of 12
- Photo: Carlos Rene Perez/Invision/AP10 of 12
- Photo: Will Binns/Pacific Coast News11 of 12
- Prev
Diane Keaton says she regrets giving Al Pacino a marriage ultimatum during their romance in the 1980s, because the demand put an end to their relationship.
The "Annie Hall" star dated a string of Hollywood actors in her youth, including Warren Beatty and Woody Allen, but it was her "Godfather" co-star Pacino who really stole her heart.
She tells People magazine, "(Pacino was) charming, hilarious, a nonstop talker. There was an aspect of him that was like a lost orphan, like this kind of crazy idiot savant. And oh, gorgeous! I was mad for him. I worked hard on that one."
The relationship fell apart when she pushed for marriage and Keaton admits it wasn't her finest hour: "I went about it not in a perfect way."
The actress, who has never wed, admits she has never since come close to becoming a wife, but says now, at 65, she's glad she didn't become a stay-at-home mom like her mother.
She says, "There was a sacrifice she had to make in not having a career. I knew marriage was not going to be a friend to me."
And the actress is no longer even interested in looking for love.
The star, who has two adopted children, adds, "Dating terrifies me. Can you imagine anything worse...? My kids think the idea's repugnant, too."
Get out the vote
- button.LOL
- button.AWW
- button.OMG
- button.FAIL
Most Watched on Wonderwall
Copycat Kylie
Take a look back at six times Kylie Jenner wore the exact same outfit as big sis Kim Kardashian West.Watch Video »
DIY Celeb Makeup
Find out how to get Jenna Dewan Tatum's long-lasting matte lip on DIY Celeb Makeup.Watch Video »
New Puppies
Meet The Rock's, the Beckhams' and Demi Lovato's new puppies on this week's Celebs Gone Social.Watch Video »
Emmy Teens
Check out six Emmy nominees' high school yearbook photos. Can you identity these pre-fame teens?Watch Video »
Perry in Peru
Check out Katy Perry's best posts from Peru during the South American leg of her Prismatic World Tour on this week's Celebs Gone Social.Watch Video »
Shailene Woodley and the stars of "Divergent" chat phobias and on-set injuries at the film's world premiere.Watch Video »


text:
Best feature of this hotel is the staff, always helpful, friendly, there when you need anything at all. We called as soon as we landed at Orlando airport, and the shuttle arrived in 10 minutes. In the short drive over, the driver told us about nearby restaurants and shopping, and assured us he could drive us over to the restaurant in the Marriott where we had dinner reservations. Arrival was a breeze, our room was ready two hours before the advertised check-in time, located where we requested. Had lunch at the bar, pretty good food and fast service there.
The hotel itself is the standard Embassy Suites arrangement, the tall, open atrium with comfortable seats and couches, a bit noisy in the evening but not audible in the rooms. The bar is smaller than some, but plenty of cafe tables and a couple of flat screen TVs. Evening reception with free drinks is always a treat, though snacks were sparse.
Room was exceptionally clean and well-tended. This is an older hotel, but obviously well maintained. Comfortable bed, both foam and feather pillows, two TVs, and a small refrigerator and microwave.
Finally, the free breakfast had everything you could want. Made to order omelets, pancakes, plenty of fresh fruits and breads.
- Official Description (provided by the hotel):
- Centrally located Embassy Suites Hotel offering a beautiful garden atrium, 174 two-room suites, and over 3,000 square feet of flexible meeting space. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Hilton Hotels, Booking.com, Expedia, Travelocity, Hotwire, TripOnline SA, Orbitz, Otel, Odigeo, Priceline, Agoda, Hotels.com and Low Cost Holidays so you can book your Embassy Suites by Hilton Orlando Airport reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Embassy Suites Orlando
- Orlando Embassy Suites


text:
Fault on both sidesOctober 14,2013
Fault on both sides
Wonderful. The states delegation is speaking out to the GOP regarding the shut down. The House has passed multiple bills to fund sectors of the government that surely they must all agree on: veterans benefits, national parks, NIH research trials, etc.
Yet the Senate (Democrats) wont consider them or negotiate. Why? They want everything up front before they come to the table. Kinda like Tip ONeill screwed Reagan with unfulfilled promises after he got his tax hikes. You all elected these nimrods. I did not.
Since when does any faction of Congress get to say no negotiating until we get what we want? With all the hostage rhetoric coming from the Senate Democrats and the White House, be honest about who is holding who hostage. The Democrat-contolled Senate and the White House are holding the American people hostage. Period.
Keith Zandy
BerlinMORE IN Letters
In a recent commentary by Jeff Danziger, the shortcomings of his many Volkswagen Beetles were... Full Story
Like most Vermonters, I support goals that would decrease our carbon footprint. Full Story
Listening to the discussion about gun control on Vermont Public Radio today, I was wondering... Full Story
- Most Popular
- Most Emailed


text:
This Friday, October 9th, CMS students will participate in the College Day San Jose Rally. Students will have an opportunity to learn a new CMS cheer, learn more about steps towards their college roadmap, and select a college for their homeroom door decorating contest!
Families can learn more about college preparation by attending a family and community conference at San Jose State University on Saturday, October 24th. Register at http://collegeday.org or call 408-924-8955.


text:
State says Big Blue wasn't making progress on corrective action plan
Indiana this week canceled IBM Corp. contract as the prime on a $1.34 billion award to overhaul the state's applications for food stamps, Medicaid and other welfare benefits. Gov. Mitch Daniels (R) said IBM was not making enough progress to fix poor services under a corrective action plan put in place last spring. "The fraud appears to have been stopped and we're still on track to save taxpayers hundreds of millions of dollars, but the intended service improvements have not been delivered, and that's not acceptable," Daniels said in a statement. An IBM official told the Associated Press that the company was making progress. He blamed the recession and high unemployment for putting more stress on the system and making changes more difficult. "IBM rejects the state's claims and believes the state's actions are unjustified," company spokesman John Buscemi said. The state's plan now is to use parts of its old system and parts of the modernized system that have worked well, Daniels said. Indiana also will continue to work with IBM's subcontractors such as Affiliated Computer Services Inc., the AP reported.
The move opens the way for ACS to work more closely with the state to "meet the needs of their vision to provide a program that best serves the citizens of Indiana," an ACS spokesman said. "ACS remains fully committed to the success of this project.."
About the Author
Nick Wakeman is the editor-in-chief of Washington Technology. Follow him on Twitter: @nick_wakeman.
E-Mail this page
Printable Format
Advanced Search
Meet 100 women and men who are doing great things in federal IT.
Click here for the full list
The outgoing speaker helped push forward data and transparency measures that have opened up the House of Representatives to the American people.
The Census Bureau announced plans to fold in new technology and third party data into its 2020 population count, but questions remain about the viability of the Bureau's enterprise IT.
A technology roadmap can help agencies reap the benefits FITARA has to offer. Here are the four stages of a successful effort.
In the newest Federal Employee Viewpoint Survey, feds show they're feeling better than they have over the past few years – but there's still room for improvement, especially in mission-critical IT.
The General Services Administration's Enterprise Infrastructure Solutions contract will anchor the agency's NS 2020 telecommunications strategy.
House and Senate both approve a measure to maintain funding at fiscal 2015 levels through Dec. 11.
The aviation regulator missed a Congressional deadline to develop rules of the sky-ways for drones.
Agency heads, acquisition officers and even CIOs don't need to be hard-core techies. FCW's four-part look at the expertise that's really required to make federal IT run.
FCW recognizes 14 individuals having an outsized impact early in their careers.
And maybe IBM had some issues with their offshore "Global Partners"?
Have to agree with Alexandria, much more behind this than we will ever know. And, the government should really have at least a couple of competent people on their payroll, not just politicians.
Not that contract companies would be fully blameless, sometimes they play politics for profit and forget the real goals but the responsibility is and should be on customer. Seen / worked too many government projects, in many countries / states, where the customer, government, has made the project fail just by incompetence. Of course, same sometimes happens in private, with internal problems in consulting company, etc. But should be cleared out before very costly and difficult cancelation / reassign of the project is needed. It's always 99% personal problems, not technical.
You don't get to offshore half of your workforce AND whine about unemployment causing you to be unable to produce. I have no pity for IBM.
IBM relies heavily on India. Though they may be compitent coders, it still requires either extremely extensive specs and business analyst who are quick to understand what is needed. Somehow either proper specs were not done or the IBM team is unable to understand or convey the problem to indian coders. If they wanted to use this model then there was certainly enough money in a billion dollar project to either move them to Indiana for a year or two, or do a better jobs in analysys and specs. You need compitent people on location with the client. Always is and always has been the problem with any project. The bigger the project, the more detached you get from the client and the less chance of success. Governments should aim at 18 month at a max.
IBM has been fired by other states for the same problems.. Indiana is just the latest who has IBM for not fulfilling the contract.
Show All Comments
8609 Westwood Center Drive, Suite 500Vienna, VA 22182-2215 703-876-5100
© 1996-2013 1105 Media, Inc. All Rights Reserved. This copy is for your personal, non-commercial use only.To order presentation-ready copies for distribution to colleagues, clients or customers, visit: www.1105Reprints.com


text:
Super 8 Marana/Tucson
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this motel rated in the past?
- Continental Breakfast
- Swimming pool
- Free High-Speed Internet
- Wheelchair accessibility
- Business Services
- Free parking
Travelers also recommend:
- More recommendations
TripAdvisor Reviews Super 8 Marana/Tucson
Travel Blogs from Marana
Today he tried to nurse...
... so I wasn't all that full. Anyway, we will try again and see what happens. This morning, James and I drove Eric to work since I need the X5 today. And they're repaving our road and Eric refuses to drive his M4 through all that. Ingrid came at 9:30 to take care of James and I went to pilates then ...
Tucson, AZ -- A Sprawling City in a Beautiful Area
... feet and weighing 16,000 pounds or more. The blossom of the saguaro is the Arizona state flower. Yesterday we visited the Arizona-Sonora Desert Museum, an interpretive center showing the diversity of the Sonoran Desert region, which is the lushest desert on earth. The museum offers a zoo, botanical garden, art gallery, natural history museum, aquarium, and aviary. One of the most interesting things ...
... finally arrived, unloaded our lawn chairs and picked a good place to sit back and watch.
SARA is a group of people... Men, women, kids, grand parents etc... who gather at least 15 times a year to blast off rockets in the Desert... Please see SARA - Southern Arizona Rocketry Association this is their official ...
... are great! And one rack is enough for 2 of us to have a couple of meals!
So at both of the Mike Shake Monday get-togethers we've run into a couple of guys who ride motorcycles… and have made some connections to ride some of the back roads… in addition I made some connections to find some spots to do some wild pig hunting… Actually they ...
Casa Grande Ruins & Ghostown Adventure SASCO
... and Design www.steelkrazy.com... And the Trendsetters from Phoenix AZ Trendsetters - Rustic Decor for your entire home, cabin ... to name a few of our favorites!
Our Friends Gail & Dale from 9 Mile Falls arrived on Wednesday and we have been running ever since … all the while taking in GORGEOUS ...


text:
10 reasons why Halloween is the absolute best holiday
I don't have a BF yet. Is something wrong with me?
My room is a disaster...HELP!
Exclusive: The Invisible Sister cast rocked sight-seeing on set in NOLA
October Boots 'n' Jackets Giveaway: Week 1 winners
We found the *perfect* sweater weather outfit
A polka dot mani you can actually DIY
GL's tasty tea guide is here to get you through fall
Sneak a peek at our awesome October/November issue starring Bea Miller!
GL's Exclusive Look at GMW's "Girl Meets World of Terror 2"
More Friends = More Fun
GL Tweets !
11 HOURS AGO Hey, West Coast! @rowblanchard + @parisberelc's #InvisibleSister on @DisneyChannel debuts in just 30mins! Who's watching? 👯👤✨💞
12 HOURS AGO Sip this! GL's tasty tea guide to get you through fall: http://t.co/cNmr79i98A pic.twitter.com/QWh5sARKMy
14 HOURS AGO Will you read the new gender-flipped #Twilight? Still can't get over it: http://t.co/ayJeNgNHfd pic.twitter.com/pJQtnyguvk
sponsored links
Check these out, too...
Tops topcoat
have gotten an edgy makeover, and you're sure to find one that fits your style.
Try matte topcoats for a really cool effect over glitter polishes, or crackle
over your neons or even holographic coats to add any polish look iridescent.
For summer nights, we'll def be sporting a classic glitter topcoat.
Essie Luxeffects Glitter Topcoats, $5 each, ulta.com
Texturize it
Textured polish is the coolest new thing to hit the nail market. Think fun finishes from concrete to leather, even fuzzy effects that make your nails look like they're wearing a fluffy scarf! We heart this sandy formula, which is sparkly and makes your nails feel like the beach.
OPI Liquid Sand Bond Girls Collection, $9, ulta.com
OMG ombré
nails look like they take a lot of work, but they are actually super easy to
create. To get this look, paint stripes of your favorite polishes next to each
other on a makeup sponge and dab the sponge on your nail over and over until
the colors blend at the edges and the color is fully saturated on your nail.
Ed. Tip: Two or three colors work best, and
non-sparkly polishes blend the easiest.
Glitter glam
lieu of glitter topcoat, glittery polishes sparkle and shimmer all on their
own. These polishes have great staying power, since the glitter helps keep the
polish bonded to your nails. Be careful though, these formulas are tough to
remove, so don't rush to try this trend if you switch up your color a lot.
UO Sparkle Collection Polish in Scorcher, $5, urbanoutfitters.com
Nail stickers
those girls who simply can't go without true nail art, nail stickers are a
great substitute for doing the hard work on your own. They come pre-printed,
and the stickers usually last at least a week without chipping. Pattern options are pretty endless. They take
time and patience to apply, but the end result is stunning.
Ed. Tip: For a creative look, put stickers on some of
your nails and use a coordinating polish on others!
Nail Rock "Chelsea" Nail Wraps, $12, asos.com
6 art school-worthy mani tricks to try now
Get your mani ready for Independence Day with this cool nail art inspo
Wear your fangirl on your fingertips with these nerdy nail art tutorials
Mani madness: Amp up your nail game with these so-sweet sets
POSTED IN beauty, nails, fast, cheap, saver, diy mani
What's *your* star quality?l
CLICK HERE to discover your star power...and snag a sneak peek at a sparkling new series!


text:
PEOPLE'S PHARMACY: Few patients read labels on drugs
Published: Thursday, January 4, 2007 at 3:30 a.m.
Last Modified: Wednesday, January 3, 2007 at 11:00 p.m.
When the Food and Drug Administration switched the prescription pain reliever Motrin (ibuprofen) to over-the-counter status in 1984, a lot of physicians were unhappy. They feared that this powerful NSAID (non-steroidal anti-inflammatory drug) might cause serious harm without medical supervision.
Many doctors opposed easy access to NSAIDs because of side effects such as fluid retention, elevated blood pressure, rash, stomach irritation and ulcers.
The FDA downplayed such concerns. Officials at the agency seemed to think that OTC NSAIDs offered people another valuable option for pain relief without serious risk.
It wasnt long before brands like Advil and Motrin IB became big sellers. Eventually Aleve (naproxen) hopped on the bandwagon. It is estimated that more than 20 million Americans take ibuprofen or naproxen each day.
Now, the FDA has decided the labels on common pain relievers need to be revised. The new warnings will caution consumers that NSAIDs can cause stomach bleeding in people older than 60 or those who have had ulcers or are taking a blood thinner. It will also point out hazards for people who combine these drugs with alcohol or take the medicines for longer than directed.
Despite this increased emphasis on stomach problems (and liver toxicity associated with acetaminophen), there will be no warnings that regular use of NSAIDs may increase the risk of heart attack or stroke. These reactions were discovered in the wake of the Vioxx scandal.
What the FDA doesnt seem to realize is that whatever it puts on the label may be irrelevant. Studies have shown that only about one consumer in five reads the instructions and warnings on the label. A few more -- nearly one in three -- bother to check the dosage information.
Perhaps thats why one person in four takes more than the recommended dose of OTC pain reliever. Most seem to think that any drug available without a prescription is safe enough that they dont need to worry about it.
Sadly, that leads to far too many overdoses and hospitalizations. Currently, the FDA estimates that as many as 200,000 Americans are hospitalized each year with serious reactions to OTC pain relievers.
People in pain are caught in a bind. Many of the drugs they rely on for relief may raise blood pressure, cause bleeding ulcers or even increase the risk for a heart attack or stroke. No wonder people are so anxious to find other alternatives to ease their discomfort.
In our new book Best Choices From The Peoples Pharmacy" (Rodale Books), we discuss many other options for pain relief, including home remedies, herbal approaches and topical NSAIDs. Drugs like Pennsaid, Voltaren Emulgel or Feldene Gel can provide relief without typical NSAID side effects. The FDA has never approved such medications for sale in the U.S., but they are available in other countries.
Were pleased the FDA has finally recognized that warnings for OTC pain relievers need to be improved. We only wish all consumers would read the labels and take these drugs seriously.
Write to Joe and Teresa Graedon in care of King Features Syndicate, 888 Seventh Ave., New York, NY 10019, or e-mail them at firstname.lastname@example.com or via their Web site: www.peoplespharmacy.org.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
Comments are currently unavailable on this article


text:
Living Room Arc Lamps
Living room arc lamps create cascading light over any space in need of extra glow. Arc lamps can be situated on the floor next to your favorite sofa or bow above your side table for a more dramatic light. Arc lamps are available in an array of sizes to favor your needs.
Trend Lighting - BFA8400 - Brella Arc Floor Lamp$344.00
Trend Lighting - TFA9030 - Triad Arc Lamp$590.00
Trend Lighting - TFA8005 - Mid Arc$336.00
Trend Lighting - Bordeaux Arc Floor Lamp$450.00


text:
April 21, 2013
First time jacking off with hello kitty in the shot. Sexy vid
Thanks for helping us associate the correct Pornstars to this video!
Help Us: Do these Pornstars appear in this video?
Pornstar Name:
Thanks for helping us sort this video!
Video Description:
DaneJones HD Student waits for her older lover to fuck her
All Comments (8)
First time jacking off with hello kitty in the shot. Sexy vid
damn its fucking nice i just cnt remain i want sm1 2 fuck me
qe rico cno
OMG I didn't know "hello kitty" was so sexy... nice vid
12;45 french (snowball kiss)
I woul deat that pussy and ass all day matter of fact Id give her a cream pie and lick her clean hot and sexy her pussy is HOT and needs a bigger cock like mine:)
Hot & sexy!


text:
A nice photo can capture the essence of a family, or just serve as a reminder of what they all looked like before they had to sell their faces to the mask store. Save face with this Groupon.
$59 for a Custom Video Slideshow ($149 Value)
To enhance a wedding, graduation, or other special occasion, video technicians craft a custom slideshow of up to 100 photographs set to the tune of the customer's chosen music. Two DVDs of the finished work, adorned with custom titles, are ready to grace screens within five to seven days.
Save Your Tapes
For 10 years, the technicians at Save Your Tapes have preserved customers' memories by transferring the contents of VHS, VHS-C, Hi-8, and Mini-DVs onto pristine DVDs. After picking up customers' tapes in person, technicians transfer their contents to DVD—complete with a custom menu and label—and place the DVD in a protective sleeve ready for customers to pick up. Mail service is also available. Save Your Tapes offers tape repair services and photo slideshows in addition to its transfer services.
90% of 237 customers recommend
"Great communication from them each step of the way. Fast turnaround. I'd definitely go back!"
"Good service and inexpensive. Great for home videos."
"They did a great job!"
4 Dominion Dr, Bldg 4, Ste 250
San Antonio, TX 78257
+12102099383Get Directions


text:
Email AlertsSimply the best deals and coupons, delivered directly to your inbox.
Today's Best Deals(popular by activity)
- JibJab - Get a 30 day FREE TRIAL to JIB JAB Send some funny personalized ecards to your friends!
- Vistaprint - Get 500 Full Color Business Cards for only $10.00 plus get Free Shipping! As Seen On TV!
- LifeExtension - Final Clearance Sale: Save Up To 75% Off!
- Athleta - 70% Off, Or Until They Run Out Sale!
- Masseys.com - Sale - Massey's Women's Shoe Sale
The Deal Wire(live deals)
iPhone AppGet great deals and coupons delivered directly to your iPhone, totally free!
Perfect Father's Day Gift Under $50 + Free Shipping! at THING REMEMBERED
A THING REMEMBERED offers huge selection of personalized gifts and unique gift ideas that can be engraved or personalized. Shop now and get Dad a wonderful gift that he will cherish forever. Buy satin gunmetal pocket watch with free valet box for just $50 and don't miss out other great items for under $50.
Also check on clearance and get even more savings plus get free shipping on orders over $100. Hurry! Offer ends soon.


text:
Theyskens' Theory's white washed-satin dress is a contemporary take on classic Grecian glamour. Team it with jet-black accessories for a bold color contrast. Shown here with a Kara Ross ring, Philippe Audibert bracelet and a Theyskens' Theory bag and shoes.
White double-layered washed-satin dress. Theyskens' Theory dress has a slight cowl neck, a high V-back, cap sleeves, gathered draping at bodice and skirt, slant pockets at wide paneled waist, a longer bubble hem at back and simply slips on. 100% polyester. Dry clean.
Product code: 113221 - Need help? Contact us


text:
Mendocino College is deeply concerned for all of those affected by the Valley Fire and the evacuations. The college will accommodate students who are unable to attend class due the crisis. A student emergency fund is available for students who have a serious demonstrated college-related need, such as replacing school supplies and textbooks, as a result of this emergency. Contact the Lake Center at 707-263-4944 for more information.
Your Community • Your College • Your Success
Advance your academic progress this fall while enjoying the new facilities and lush landscape that surround Mendocino College. We offer a robust selection of classes for either the continuing, returning or new student. Take advantage of our numerous online offerings or come to campus and enjoy the beautiful fall colors, temperate weather, free parking, small class sizes, and outstanding faculty and staff.


text:
I am excited, but nervous since I am newly pregnant (5.5 weeks). I have run two halves in the past couple months, so I should be ok. I plan to walk some and take it very easy. Really dont want anything bad to happen
running a half marathon on Sunday!
Posted 08/25/2012
Comments (4)
Posted 08/25/2012
Good luck and have fun! You probably won't be running another one for awhile :-)
Posted 08/28/2012
Good luck!
Kim (32), Mark (33), Kara (5), Cole (3), Weston (born 4/5/13) 2 m/c (March 06, June 12)
Kim (32), Mark (33), Kara (5), Cole (3), Weston (born 4/5/13) 2 m/c (March 06, June 12)
Aprilmomma7 · Original Poster
Posted 09/15/2012
It went great! Ran it about 10 minutes slower than my half wherei wasn't pregnant the month prior. Kept my heart rate under 165 just to be safe. I am 8 weeks, but can't run any more because of a blood clot, I am on pelvic rest (not related to my running).


text:
Tim Sets Swampstock Date
Tim McGraw is set to host his Swampstock 2008 concert event in Rayville, La., Sept. 13.
Swampstock 2008 is a presentation of Tim and wife Faith Hill's Neighbor's Keeper Foundation and net proceeds will benefit the Foundation's local initiatives. Tim's past Swampstock events have included an all-star concert featuring several of Tim's celebrity friends. More details on this year's Swampstock will be available soon. Tim began Swampstock in 1994 as a way of giving back to his hometown community.


text:
Pretty and brains at it best; come see "A Dynamic Invitation" in person and see what you think. Super mover with a pedigree that stands behind the winners. "Invitation Only" is the sire of 210 World Championships, Congress Championships, and Reserve Championships, and a 2008 NSBA Hall of Fame Inductee. "A Dynamic Invitation's" dam is "Pretty Special Silk" sired by "Dynamic Deluxe"; know for his "sit back and lope" gait. "Dynamic Deluxe" appeared on the Leading Sires list for over a decade, and was a Superior Western Pleasure horse with 111 points, plus an AQHA Congress championship to his name.... (read more)
We are a small Appaloosa Farm, who have been breeding Quality Appaloosas, since 1996. Our Bloodlines include, Potential Investment, Star J, Dreamfinder, Colida, Go Bay Go, Chief Chelsea, Impress Me Shanon, Prince Shannon, etc. Feel free to visit our website. Call or Email for any i
Avoid Scams and Fraud - Potential areas of fraud: wire transfer, moneygrams, money orders, cashier checks, shipping, escrow, "transaction protection", "guarantee". Check out the Buyer Safety section for more info.


text:
Dash Knobs & Cigarette Lighters
Select from our extensive list of Dodge Dash Caps below. We offer an industry leading 30-day Guarantee so that you can Shop with confidence! Select from the products or categories below to narrow the selection in Dash Caps for your Dodge.
DASHTOP DASH TOP COVER. Molded plastic dashboard cover fits over the existing dash. Beautifying old cracked dashes. A great cover-up that... Read more
ACCU-FORM MOLDED DASH CAPS;. Vacuum-formed plastic with ultraviolet inhibitors for cars and trucks. Read more
Coverlay's interior restoration kits are designed to give you almost if not everything you need to restore your newer or late model... Read more
All Makes | All Brands | Sitemap | Product Categories


text:
Your browser currently is not set to accept Cookies. Please turn it on or check if you have another program set to block cookies.
Marlo Suit Pant in New Tailor
(see more colors)
Wellar HC Suit Jacket in New Tailor
The Modern Jean
Look 14
Look 8
Packor CW Pant in Minden
Malcolm 1B TX Jacket in Barinas
Zaine WD Pant in Haddon
Plymouth Pant in Gleason
Plymouth CW Pant in Minden
The Slim Fit
Guys' Night Out
Raffi JE Z Pant in Hueron
Dover Spread Dress Shirt in Kenai
The Classic Fit
Zaine TT S Short in Linthal
The Big Pitch
Jake TX Pant in Barinas
Marlo T U Pant in Calvary Twill
Wellar Jacket in Eldoret
The Moto Trouser
Look 3
Marlo T U Pant in Akron
Raffi BL in Rhine
Zaine Pant in Witten
Marlo U Pant in Blenheim
Bikor Pant in Revore
Bradley Pant in Brasted
Haydin Je N Z Pant in Monford
Zaine TT Pant in Revore
Sten S Short in Entick
Beckit SW Z Short in Odium
Zaine F Pant in Penury
Zaine F Pant in Milroy
Jake W Pant in Cambria
Raffi Je N Z Pant in Motley
Haydin Je N Z Pant in Rigg
Raffi Je Z Pant in Garrett
Dover Spread Dress Shirt in Lingham
Zaine SW Pant in Neoteric
Marlo U Pant in New Tailor
Haydin Pant in Writer
Look 5
Wimso Pant in Ventnore
Zaine S Short in Fawe
Wellar PA Jacket in Bardolph
Jake W Pant in Carling
Marlo U Pant in Higgins
Jake W Pant in Haddon
Weller PE Tuxedo Jacket in Hamburg
Marlo U Pant in Wulfert
Jake W Pant in Alperton
Joseph SW Pant in Clymer
Haydin JE N Z Pant in Linthal
Marlo P Tuxedo Pant in Hamburg
Marlo T U Pant in Prosperous
Zaine F Pant in Heyward
Dover Point Dress Shirt in Pritchard
Jake W Pants in Tolosa
Malcolm Jacket in Akron
Dover Point Dress Shirt in Limerston
Raffi Je Pant in Railton
Marlo Pant in Straslund
Wellar Jacket in Mazuma
Dover Spread CPFC Dress Shirt in Noville
Jake W Pant in Wescombe
Malcolm Jacket in Prosperous
Wellar Jacket in Blenheim
© 2015 Theory


text:
Anthony Davis vs. Elijah Tillery
From BoxRec
1984-09-19 : Anthony Davis 192 lbs beat Elijah Tillery 194½ lbs by UD in round 12 of 12
- Location: Las Vegas, Nevada, USA
- Referee: Davey Pearl
- NABF Cruiserweight Title (1st defense of Davis)
- Davis down in round 1 from a right hand to the head.
- Tillery was warned by the referee for lack of action in round 11.
|Preceded by:
Davis vs. Burnett
| NABF Cruiserweight Title Fight
# 6
|Succeeded by:
Davis vs. Ali


text:
2 Bedroom flat or one bedroom one office
Please read carefully: Dates for rental are: 01/11/15 - 15/01/16 These dates are not negotiable as I will be living in the flat until 1st November and coming back 16th January. Right now the flat is one bedroom with an office. You can make th
- Date available: 01 Nov 2015
- Flat
- 4 Beds


text:
Goose Rocks Beach Association Inc
Rating: 0 stars 0 0 review 55
Nonprofit Issues:
Po Box 140 Kennebunkport ME 04046 USA
Youth and adult recreational activities including teaching of athletics and safety training.
Filter Reviews by Role
Promote This Nonprofit
GreatNonprofits badges allow you to raise awareness of your favorite nonprofits on your own web sites!
GreatNonprofits News
See What The Most Quotable Nonprofit Leaders are Saying
Reviews for Goose Rocks Beach Association Inc
Get discovered. Invite people to share their experiences about this nonprofit!


text:
Printable Area
"The tart taste of cider is a perfect complement to any type of poultry, and this roasted chicken is no exception. Though you need to allow time for this bird to brine, your patience will be rewarded with a flavor-packed, moist bird. Best of all, making the bird yourself will save you 200 milligrams of sodium, compared to store-bought varieties. Brining overnight in a salt-and-cider mixture maked this chicken recipe incredibly flavorful and moist; basting with reduced apple cider adds a hint of sweetness to the finished roasted chicken. Use tongs to carefully remove skin from the hot chicken."
Serving Size: 1 (786 g)
Servings Per Recipe: 8


text:
This is a comprehensive cob workshop that can be taken via the internet. This is what that means for you: You can learn from home at your own pace, You don't need to ever take vacation days off, No travel required, You only pay a fraction of the cost! Continue reading
Online Cob Workshop Review – Solution to Your Workshop Woes
Natural Remodeling – Limewash Paint
Here is a simple, yet functional, way to start your natural remodeling by using a limewash paint. Unfortunately, we can't all have our own naturally built home created out of materials of earth and straw. We can however implement certain natural building materials and finishes into our currently existing homes and buildings though.
I want to introduce you to a simple way to make and apply one type of natural finish to your current home. This natural finish is a basic limewash paint. Continue reading
Building a Cob House – Your Checklist for Success
Building a home is a major undertaking that will cost you a lot of money and time. It can be like putting together a large three dimensional puzzle that must also be able to interact with the environment and the conditions around it.
Building a home is also a lot of hard work, both physically and mentally, and will require you to use a variety of skills. The more… Continue reading
Do not use earthbags for stemwall foundation
This morning, I received an email newsletter from a prominent Natural Builder explaining why they had chosen to build a stemwall foundation using earthbags.
I was really surprised when I read this email! Especially when I saw that they were actually filling the polypropylene bags (earthbgas) with just soil (and maybe some aggregate too). I surely thought that they would at least fill them with just gravel! It sounded… Continue reading
"Dirt Cheap" Cob Homes
I have a lot of people ask me…
"How much does a cob home cost?"
"I heard cob homes are really cheap to build. How much does it cost per square foot?"
These are good questions to ask, but they're very broad and can't really be answered in a general sense.
The cost of a cob home, just like any type of home, will… Continue reading
Earth Building Techniques – Build Your Home with Earth
Beginnings of Earth Building Techniques
Earth building techniques have been around for thousands of years. Since before our recorded history, people have been using the earth to build with. That's why I tell people that earth building techniques are nothing new. In fact, they are very ancient. Today, the first-world, "developed" nations are just having a revival of these age-old… Continue reading
Cob House Travel Tour – East Coast
The east coast of the United States isn't known for its abundance of cob homes and other natural homes, but there is actually a lot going on over on this side of the country. Some of this development has been recent and some of it has just been tucked away and out of view for the most part. Continue reading
My Top 3 Reasons to Build a Cob House
One of the main things that led me to natural building methods was my search for ways to build a non-toxic, healthy home that I could live in and that it not tax my body.
Modern conventional building is highly toxic and potentially damaging to our health. From off-gassing in paints, carpets, glues, plastics, and a plethora of other synthetic materials, our bodies are constantly bombarded with a host of foreign and toxic onslaughts.
Our bodies each have a certain threshold of how much toxicity that they can process daily.
When the body's threshold is surpassed with over exposure to environmental toxins… Continue reading
Cob Homes – Indoor Temperatures, Insulation, and Thermal Retention
Some common questions that I receive from people interested in building a cob home:
– What does the temperature feel like inside a cob house in the summer? And in the winter?
– Can I install central heating and air conditioning in my cob house?
These are very good questions!
Earth soil has proven to be a very suitable and successful building material throughout the world's… Continue reading
Soil Types for Cob Building
Soil types vary by each region and location, but the majority of soil types will work for building cob and earthen structures. It is actually rare to find soil that will not work for cob. This is a good thing for the case of earthen building!
Soils consist mainly of a mixed combination of silt, sand, and clay. In the case of earthen building, silt is not a bad… Continue reading


text:
Are you Joerg Bewersdorf?Claim your profile
Publications (78)450.25 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: IsoSTED nanoscopy, a variant of stimulated emission depletion (STED) microscopy, utilizes two opposing objective lenses and features the highest three-dimensional resolution of STED nanoscopes currently available. However, this technique is limited by axially repetitive side minima in the interference pattern of the depletion point-spread function (PSF), which can lead to ghost images. Here, we describe novel strategies to further improve the performance of isoSTED nanoscopy by reshaping the PSF. In particular, we propose employing moderate defocus on the depletion beam to reduce the side minima. Furthermore, we demonstrate a simplified alternative based on objective misalignment and quantitatively compare the expected performance between the two approaches.Optics Letters 08/2015; 40(15):3627-3630. DOI:10.1364/OL.40.003627 · 3.29 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Single-molecule switching nanoscopy overcomes the diffraction limit of light by stochastically switching single fluorescent molecules on and off, and then localizing their positions individually. Recent advances in this technique have greatly accelerated the data acquisition speed and improved the temporal resolution of super-resolution imaging. However, it has not been quantified whether this speed increase comes at the cost of compromised image quality. The spatial and temporal resolution depends on many factors, among which laser intensity and camera speed are the two most critical parameters. Here we quantitatively compare the image quality achieved when imaging Alexa Fluor 647-immunolabeled microtubules over an extended range of laser intensities and camera speeds using three criteria - localization precision, density of localized molecules, and resolution of reconstructed images based on Fourier Ring Correlation. We found that, with optimized parameters, single-molecule switching nanoscopy at high speeds can achieve the same image quality as imaging at conventional speeds in a 5-25 times shorter time period. Furthermore, we measured the photoswitching kinetics of Alexa Fluor 647 from single-molecule experiments, and, based on this kinetic data, we developed algorithms to simulate single-molecule switching nanoscopy images. We used this software tool to demonstrate how laser intensity and camera speed affect the density of active fluorophores and influence the achievable resolution. Our study provides guidelines for choosing appropriate laser intensities for imaging Alexa Fluor 647 at different speeds and a quantification protocol for future evaluations of other probes and imaging parameters.PLoS ONE 05/2015; 10(5):e0128135. DOI:10.1371/journal.pone.0128135 · 3.23 Impact Factor
Article: Adaptive optics correction of specimen-induced aberrations in single-molecule switching microscopy[Show abstract] [Hide abstract]
ABSTRACT: Single-molecule switching (SMS) microscopy is a super-resolution method capable of producing images with resolutions far exceeding that of the classical diffraction limit. However, like all optical microscopes, SMS microscopes are sensitive to, and often limited by, specimen-induced aberrations. Adaptive optics (AO) has proven beneficial in a range of microscopes to overcome the limitations caused by aberrations. We report here on new AO methods for SMS microscopy that enable the feedback correction of specimen-induced aberrations. The benefits are demonstrated through two-dimensional and three-dimensional STORM imaging. We expect that this advance will broaden the scope of SMS microscopy by enabling deep-cell and tissue-level imaging.Optica 02/2015; 2(2):177. DOI:10.1364/OPTICA.2.000177
- Biophysical Journal 01/2015; 108(2):475a. DOI:10.1016/j.bpj.2014.11.2599 · 3.97 Impact Factor
Article: Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes[Show abstract] [Hide abstract]
ABSTRACT: Extended synaptotagmins (E-Syts) are a recently identified family of proteins that tether the endoplasmic reticulum (ER) to the plasma membrane (PM) in part by conferring regulation of cytosolic calcium (Ca2+) at these contact sites (Cell, 2013). However, the mechanism by which E-Syts link this tethering to Ca2+ signaling is unknown. Ca2+ waves in polarized epithelia are initiated by inositol 1,4,5-trisphosphate receptors (InsP3Rs), and these waves begin in the apical region because InsP3Rs are targeted to the ER adjacent to the apical membrane. In this study we investigated whether E-Syts are responsible for this targeting. Primary rat hepatocytes were used as a model system, because a single InsP3R isoform (InsP3R-II) is tethered to the peri-apical ER in these cells. Additionally, it has been established in hepatocytes that the apical localization of InsP3Rs is responsible for Ca2+ waves and secretion and is disrupted in disease states in which secretion is impaired. We found that rat hepatocytes express two of the three identified E-Syts (E-Syt1 and E-Syt2). Individual or simultaneous siRNA knockdown of these proteins did not alter InsP3R-II expression levels, apical localization or average InsP3R-II cluster size. Moreover, apical secretion of the organic anion 5-chloromethylfluorescein diacetate (CMFDA) was not changed in cells lacking E-Syts but was reduced in cells in which cytosolic Ca2+ was buffered. These data provide evidence that E-Syts do not participate in the targeting of InsP3Rs to the apical region. Identifying tethers that bring InsP3Rs to the apical region remains an important question, since mis-targeting of InsP3Rs leads to impaired secretory activity.PLoS ONE 12/2014; 9(12):e114043. DOI:10.1371/journal.pone.0114043 · 3.23 Impact Factor
Article: Hochaufgelöste Visualisierung des Golgi-Apparats in lebenden Zellen mit einem bioorthogonalen Ceramid[Show abstract] [Hide abstract]
ABSTRACT: Wir berichten über eine Lipid-basierte Strategie zur Visualisierung von Struktur und Dynamik des Golgi-Apparats in lebenden Zellen mithilfe hochauflösender Mikroskopie. Die Methode basiert auf zwei neuen Reagentien: einem trans-Cycloocten enthaltenden Ceramid-Lipid (Cer-TCO) und einem hoch reaktiven, Tetrazin-markierten Nah-IR-Farbstoff (SiR-Tz). Diese beiden Komponenten reagieren in einer extrem schnellen Tetrazin-Klick-Reaktion zu Cer-SiR, einer sehr photostabilen Verbindung, welche die Visualisierung des Golgi-Apparats sowohl mit 3D-Konfokalmikroskopie als auch mit hochauflösender Mikroskopie über eine längere Zeitspanne ermöglicht. Cer-SiR ist nicht toxisch bis zu einer Konzentration von 2 μM und stört weder die Mobilität von Enzymen innerhalb des Golgi-Apparats noch den Transport von Fracht vom Endoplasmatischen Retikulum durch den Golgi-Apparat zur Plasmamembran.Angewandte Chemie 09/2014; 126(38). DOI:10.1002/ange.201403349
- [Show abstract] [Hide abstract]
ABSTRACT: We report a lipid-based strategy to visualize Golgi structure and dynamics at super-resolution in live cells. The method is based on two novel reagents: a trans-cyclooctene-containing ceramide lipid (Cer-TCO) and a highly reactive, tetrazine-tagged near-IR dye (SiR-Tz). These reagents assemble via an extremely rapid "tetrazine-click" reaction into Cer-SiR, a highly photostable "vital dye" that enables prolonged live-cell imaging of the Golgi apparatus by 3D confocal and STED microscopy. Cer-SiR is nontoxic at concentrations as high as 2 μM and does not perturb the mobility of Golgi-resident enzymes or the traffic of cargo from the endoplasmic reticulum through the Golgi and to the plasma membrane.Angewandte Chemie International Edition 09/2014; 53(38). DOI:10.1002/anie.201403349 · 11.26 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Focal adhesions (FAs) are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of FAs is critical for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating FA dynamics. Here, we identify TRIM15, a member of the TRIpartite Motif protein family, as a paxillin-interacting factor and a component of FAs. TRIM15 localizes to focal contacts in a myosin II-independent manner by an interaction between its coiled coil domain and the LD2 motif of paxillin. Unlike other FA proteins, TRIM15 is a stable FA component with restricted mobility due to its ability to form oligomers. TRIM15-depleted cells display impaired cell migration and FA disassembly rates in addition to enlarged FAs. Thus, our studies demonstrate a cellular function for TRIM15 as a regulatory component of FA turnover and cell migration.Development 07/2014; 127(18). DOI:10.1242/jcs.143537 · 6.46 Impact Factor
Article: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B[Show abstract] [Hide abstract]
ABSTRACT: Fronto-temporal lobar degeneration with TDP-43 (FTLD-TDP) is a fatal neurodegeneration. TMEM106B variants are linked to FTLD-TDP risk, and TMEM106B is lysosomal. Here, we focus on neuronal TMEM106B, and demonstrate co-localization and traffic with lysosomal LAMP-1. pH-sensitive reporters demonstrate that the TMEM106B C-terminus is lumenal. The TMEM106B N-terminus interacts with endosomal adaptors and other TMEM106 proteins. TMEM106B knockdown reduces neuronal lysosomal number and diameter by STED microscopy, and overexpression enlarges LAMP-positive structures. Reduction of TMEM106B increases axonally transported lysosomes, while TMEM106B elevation inhibits transport and yields large lysosomes in the soma. TMEM106B overexpression alters lysosomal stress signaling, causing a translocation of the mTOR-sensitive transcription factor, TFEB, to neuronal nuclei. TMEM106B loss-of-function delays TFEB translocation after Torin-1-induced stress. Enlarged TMEM106B-overexpressing lysosomes maintain organelle integrity longer after lysosomal photodamage than do control lysosomes, while small TMEM106B-knockdown lysosomes are more sensitive to illumination. Thus, neuronal TMEM106B plays a central role in regulating lysosomal size, motility and responsiveness to stress, highlighting the possible role of lysosomal biology in FTLD-TDP.Molecular and Cellular Neuroscience 07/2014; 61. DOI:10.1016/j.mcn.2014.07.006 · 3.84 Impact Factor
- Biochimica et Biophysica Acta (BBA) - Bioenergetics 07/2014; 1837:e30. DOI:10.1016/j.bbabio.2014.05.305 · 5.35 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The widely conserved ParABS system plays a major role in bacterial chromosome segregation. How the components of this system work together to generate translocation force and directional motion remains uncertain. Here, we combine biochemical approaches, quantitative imaging and mathematical modeling to examine the mechanism by which ParA drives the translocation of the ParB/parS partition complex in Caulobacter crescentus. Our experiments, together with simulations grounded on experimentally-determined biochemical and cellular parameters, suggest a novel 'DNA-relay' mechanism in which the chromosome plays a mechanical function. In this model, DNA-bound ParA-ATP dimers serve as transient tethers that harness the elastic dynamics of the chromosome to relay the partition complex from one DNA region to another across a ParA-ATP dimer gradient. Since ParA-like proteins are implicated in the partitioning of various cytoplasmic cargos, the conservation of their DNA-binding activity suggests that the DNA-relay mechanism may be a general form of intracellular transport in bacteria. DOI: http://dx.doi.org/10.7554/eLife.02758.001eLife Sciences 05/2014; 3(3):e02758. DOI:10.7554/eLife.02758 · 9.32 Impact Factor
Article: Erratum: Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3[Show abstract] [Hide abstract]
ABSTRACT: The components supporting autophagosome growth on the cup-like isolation membrane are likely to be different from those found on closed and maturing autophagosomes. The highly curved rim of the cup may serve as a functionally required surface for transiently associated components of the early acting autophagic machinery. Here we demonstrate that the E2-like enzyme, Atg3, facilitates LC3/GABARAP lipidation only on membranes exhibiting local lipid-packing defects. This activity requires an amino-terminal amphipathic helix similar to motifs found on proteins targeting highly curved intracellular membranes. By tuning the hydrophobicity of this motif, we can promote or inhibit lipidation in vitro and in rescue experiments in Atg3-knockout cells, implying a physiologic role for this stress detection. The need for extensive lipid-packing defects suggests that Atg3 is designed to work at highly curved membranes, perhaps including the limiting edge of the growing phagophore.Nature Cell Biology 04/2014; 16(8). DOI:10.1038/ncb2940 · 19.68 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Methods based on single-molecule localization and photophysics have brought nanoscale imaging with visible light into reach. This has enabled single-particle tracking applications for studying the dynamics of molecules and nanoparticles and contributed to the recent revolution in super-resolution localization microscopy techniques. Crucial to the optimization of such methods are the precision and accuracy with which single fluorophores and nanoparticles can be localized. We present a lucid synthesis of the developments on this localization precision and accuracy and their practical implications in order to guide the increasing number of researchers using single-particle tracking and super-resolution localization microscopy.Nature Methods 02/2014; 11(3):253-66. DOI:10.1038/nmeth.2843 · 32.07 Impact Factor
Article: Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting[Show abstract] [Hide abstract]
ABSTRACT: Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids, such as triacylglycerol (TG), as reservoirs of metabolic energy and membrane precursors. The Arf1/COPI protein machinery, known for its role in vesicle trafficking, regulates LD morphology, targeting of specific proteins to LDs and lipolysis through unclear mechanisms. Recent evidence shows that Arf1/COPI can bud nano-LDs (∼60 nm diameter) from phospholipid-covered oil/water interfaces in vitro. We show that Arf1/COPI proteins localize to cellular LDs, are sufficient to bud nano-LDs from cellular LDs, and are required for targeting specific TG-synthesis enzymes to LD surfaces. Cells lacking Arf1/COPI function have increased amounts of phospholipids on LDs, resulting in decreased LD surface tension and impairment to form bridges to the ER. Our findings uncover a function for Arf1/COPI proteins at LDs and suggest a model in which Arf1/COPI machinery acts to control ER-LD connections for localization of key enzymes of TG storage and catabolism. DOI: http://dx.doi.org/10.7554/eLife.01607.001eLife Sciences 02/2014; 3(3):e01607. DOI:10.7554/eLife.01607 · 9.32 Impact Factor
Article: Advances in Live Cell NanoscopyBiophysical Journal 01/2014; 106(2):6a. DOI:10.1016/j.bpj.2013.11.069 · 3.97 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Localization-based superresolution imaging is dependent on finding the positions of individual fluorophores in a sample by fitting the observed single-molecule intensity pattern to the microscope point spread function (PSF). For three-dimensional imaging, system-specific aberrations of the optical system can lead to inaccurate localizations when the PSF model does not account for these aberrations. Here we describe the use of phase-retrieved pupil functions to generate a more accurate PSF and therefore more accurate 3D localizations. The complex-valued pupil function contains information about the system-specific aberrations and can thus be used to generate the PSF for arbitrary defocus. Further, it can be modified to include depth dependent aberrations. We describe the phase retrieval process, the method for including depth dependent aberrations, and a fast fitting algorithm using graphics processing units. The superior localization accuracy of the pupil function generated PSF is demonstrated with dual focal plane 3D superresolution imaging of biological structures.Optics Express 12/2013; 21(24):29462-87. DOI:10.1364/OE.21.029462 · 3.49 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: A core prediction of the vesicular transport model is that COPI vesicles are responsible for trafficking anterograde cargoes forward. In this study, we test this prediction by examining the properties and requirements of inter-Golgi transport within fused cells, which requires mobile carriers in order for exchange of constituents to occur. We report that both small soluble and membrane-bound secretory cargo and exogenous Golgi resident glycosyl-transferases are exchanged between separated Golgi. Large soluble aggregates, which traverse individual stacks, do not transfer between Golgi, implying that small cargoes (which can fit in a typical transport vesicle) are transported by a different mechanism. Super-resolution microscopy reveals that the carriers of both anterograde and retrograde cargoes are the size of COPI vesicles, contain coatomer, and functionally require ARF1 and coatomer for transport. The data suggest that COPI vesicles traffic both small secretory cargo and steady-state Golgi resident enzymes among stacked cisternae that are stationary. DOI: http://dx.doi.org/10.7554/eLife.01296.001eLife Sciences 10/2013; 2(2):e01296. DOI:10.7554/eLife.01296 · 9.32 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The application of two-photon activation of photoactivatable fluorescent proteins is limited by a lack of information about two-photon activation rates. Here we present rates for the commonly used photoactivatable proteins PAmCherry, PAmKate and PA-GFP at different wavelengths using a novel method that allows us to determine the two-photon activation rates directly, independent of any reference data, with microscopic sample volumes. We show that PAmCherry features the highest rates of the tested proteins at 700 nm activation wavelength followed by PAmKate. Towards longer wavelengths, two-photon activation rates decrease for all three proteins. For PAmCherry, our data contradicts an activation model relying solely on two-photon activation and suggests additional activation pathways requiring at least two absorption steps. Our method is readily expandable to other photoactivatable fluorescent molecules. The presented results allow optimization of experimental conditions in spectroscopic and imaging techniques such as super-resolution fluorescence microscopy.Physical Chemistry Chemical Physics 07/2013; 15(36). DOI:10.1039/c3cp51035b · 4.49 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Stimulated emission depletion (STED) microscopy provides diffraction-unlimited resolution in fluorescence microscopy. Imaging at the nanoscale, however, requires precise alignment of the depletion and excitation laser foci of the STED microscope. We demonstrate here that adaptive optics can be implemented to automatically align STED and confocal images with a precision of 4.3±2.3 nm.Optics Letters 06/2013; 38(11):1860-2. DOI:10.1364/OL.38.001860 · 3.29 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Newly developed scientific complementary metal-oxide semiconductor (sCMOS) cameras have the potential to dramatically accelerate data acquisition, enlarge the field of view and increase the effective quantum efficiency in single-molecule switching nanoscopy. However, sCMOS-intrinsic pixel-dependent readout noise substantially lowers the localization precision and introduces localization artifacts. We present algorithms that overcome these limitations and that provide unbiased, precise localization of single molecules at the theoretical limit. Using these in combination with a multi-emitter fitting algorithm, we demonstrate single-molecule localization super-resolution imaging at rates of up to 32 reconstructed images per second in fixed and living cells.Nature Methods 05/2013; 10(7). DOI:10.1038/nmeth.2488 · 32.07 Impact Factor
Top Journals
- Biophysical Journal (15)
- Optics Express (5)
- Nature Methods (4)
- eLife Sciences (4)
- Optics Letters (3)
Yale University
New Haven, Connecticut, United States
- • Department of Cell Biology
- • Department of Biomedical Engineering
Yale-New Haven HospitalNew Haven, Connecticut, United States
Max Planck Institute for Biophysical Chemistry
Göttingen, Lower Saxony, Germany
- Department of NanoBiophotonics
University of Maine
Orono, Minnesota, United States
- • Department of Physics and Astronomy
- • Department Mathematics & Statistics
The Jackson LaboratoryBar Harbor, Maine, United States


text:
Town Square
Sort by: Most recent topic/comment Most viewed Most comments
Navigation tip: Clicking on any category label will display all recent posts in that category
PALO ALTO ISSUESA call for more housing in Palo Alto
With home values soaring and affordable housing in short supply, Palo Alto residents appealed to the City Council on Monday...Original post made on Oct. 6, 2015
Last comment by Midtown, 2 minutes ago | 47 comments | 2093 Views
PALO ALTO ISSUESPalo Alto treads cautiously on fiber network
With Google looming as a major wildcard, Palo Alto officials agreed on Monday to wait until next year before making any decisions...Original post made on Sep. 29, 2015
Last comment by Slow Down, 8 minutes ago | 132 comments | 3888 Views
CRIMES & INCIDENTSWoman in Stanford sexual-assault case testifies
The woman whom former Stanford University student Brock Turner allegedly raped on campus in January appeared in court in...Original post made on Oct. 5, 2015
Last comment by Value, 10 minutes ago | 5 comments | 2030 Views
SCHOOLS & KIDSCommittee: Elementary enrollment in Palo Alto is stable, not growing
The chair of a school district subcommittee on elementary enrollment urged the school board and community members at a board...Original post made on Oct. 6, 2015
Last comment by Reality check, 11 minutes ago | 7 comments | 611 Views
PALO ALTO ISSUESChanges for Charleston-Arastradero approved
No traffic-calming project has caused as much road rage in Palo Alto as the city's decade-long experiment with the Chareston-Arastradero...Original post made on Sep. 29, 2015
Last comment by Terman mom, 41 minutes ago | 44 comments | 5935 Views
PALO ALTO ISSUESMayor commits to eradicating homelessness among veterans
Citing the deaths of two unhoused women in Palo Alto parks two years ago as emblematic of the need to end homelessness in...Original post made on Oct. 4, 2015
Last comment by They Deserve More, 43 minutes ago | 8 comments | 1087 Views
SCHOOLS & KIDSPAUSD committee recommends more traffic in Barron Park
I just heard about a special school board meeting tonight where a committee is apparently recommending moving all Los Altos...Original post made by Barron Parker on Oct. 5, 2015
Last comment by Please try harder, 1 hour ago | 41 comments | 757 Views
PALO ALTO ISSUESPalo Alto trees dying in greater numbers
As the drought drags through its fourth year, Palo Alto's parched trees are dying in greater numbers, prompting city officials...Original post made on Oct. 1, 2015
Last comment by Grey is the new green, 1 hour ago | 40 comments | 4250 Views
PALO ALTO ISSUESAircraft noise
I have just spent some time emailing Anna Eshoo and Barbara Boxer (you have to fill out their website) urging them as our...Original post made by stephanie enos on Oct. 2, 2015
Last comment by Peter Carpenter, 2 hours ago | 18 comments | 424 Views
AROUND TOWNCatching neighbors who fall through the gap
A Palo Alto neighborhood group is working to turn a holiday food drive for needy neighbors into a monthly grocery giveaway....Original post made on Jan. 29, 2013
Last comment by Neighbors Helping Neighbors, 2 hours ago | 9 comments | 35507 Views
AROUND TOWNGroup of residents shelters, feeds the needy and homeless
Concerned about people sleeping on the streets or in their cars during the recent cold snap, Midtown-based Neighbors Helping...Original post made on Jan. 25, 2014
Last comment by Neighbors Helping Neighbors, 2 hours ago | 13 comments | 200642 Views
PALO ALTO ISSUESIs Comcast really the only internet option in this town?
Hi - I currently have Comcast/Xfinity and its fine (fast, good service) but I was wondering about cheaper internet/tv/phone...Original post made by Midtowner on Oct. 1, 2015
Last comment by Neighbor, 3 hours ago | 6 comments | 249 Views
AROUND TOWNPalo Alto's popular muralist Greg Brown dies
Greg Brown, a Palo Alto muralist whose elaborate, realistic and often whimsical depictions of crooks, aliens, cunning animals...Original post made on Sep. 2, 2014
Last comment by Sandro Lane, 3 hours ago | 45 comments | 12981 Views
PALO ALTO ISSUESFour-story hotel proposed for El Camino Real
A proposal to demolish a two-story motel on El Camino Real and replace it with a 50-foot-tall hotel elicited early skepticism...Original post made on Oct. 2, 2015
Last comment by resident 1, 4 hours ago | 15 comments | 5156 Views
SCHOOLS & KIDSPrioritizing choice programs. No new elementary school.
The PAUSD Board of Education will receive an Enrollment Management Advisory Committee (EMAC) Update at a study session tonight,...Original post made by South PA Parent on Oct. 5, 2015
Last comment by Sense, 5 hours ago | 22 comments | 400 Views
PALO ALTO ISSUESHow do I get my deposit back from Landlord? He's 45 days
I sure would love some helpful feedback. I rented a house for nearly three years. Gave my notice (with more than 60 days...Original post made by single mom, reliable tenant in distress on Oct. 5, 2015
Last comment by single mom, reliable tenant in distress, 12 hours ago | 9 comments | 155 Views
SCHOOLS & KIDSAchievement gap persists in new state test scores
While school district staff celebrated at Tuesday's school board meeting the high achievement of most Palo Alto Unified students...Original post made on Sep. 30, 2015
Last comment by @tension, 12 hours ago | 46 comments | 4332 Views
SCHOOLS & KIDSCastilleja proposes underground garage
Castilleja School has a new solution to a years-long battle over increasing enrollment and thus traffic in the surrounding...Original post made on Feb. 2, 2015
Last comment by Barron Park Dad, 13 hours ago | 29 comments | 7101 Views
PALO ALTO ISSUESOn homelessness, and those who strive to help
I have spent more than 3,920 hours working with the homeless population in Palo Alto. To most people employed in the social...Original post made on Oct. 2, 2015
Last comment by Neighbors Helping Neighbors, 17 hours ago | 8 comments | 2136 Views
PALO ALTO ISSUESShop Talk: The Nest comes to Palo Alto
The Nest boutique hotel comes to Palo Alto's El Camino Real, bringing the tally to four new hotels in the region this year. Read...Original post made on Oct. 1, 2015
Last comment by Eva, 18 hours ago | 5 comments | 3302 Views
Southern California chain snags La Boulange space in Palo Alto
By Elena Kadvany | 5 comments | 2,163 views
The Food Party! Top Ten List
By Laura Stec | 0 comments | 1,107 views
Fee Waivers
By John Raftrey and Lori McCormick | 1 comment | 967 views
Lessons in marketing yourself: "Making lemonade" from the Presidential campaigns
By Douglas Moran | 0 comments | 436 views


text:
San Diego (0-4) at Jacksonville (0-4)
With a quarterback controversy brewing and their star receiver returning to the lineup, the Jacksonville Jaguars look to earn their first win of the season as they face another winless team, the San Diego Chargers.
Rookie quarterback Byron Leftwich started his first game last Sunday in place of veteran Mark Brunell, who was nursing a gash on his left elbow that required five stitches.
Leftwich was 17-for-36 for 231 yards with one touchdown and three interceptions in the Jaguars' 24-20 loss to the Houston Texans. He hooked up with Troy Edwards on an 84-yard touchdown pass, the longest scoring play in team history and the longest play in the league this season.
Coach Jack Del Rio announced Thursday that Leftwich would start against the Chargers, after the rookie took the majority of the snaps with the first team for the second straight day. Brunell didn't take any.
"The injury plays into it a little bit," Del Rio said. "And I feel like this is our best option to help us win."
The left-handed Brunell is listed as questionable for Sunday with a cut on his left elbow. He said the elbow is fine, however, and he looked good throwing in individual drills early in practice.
"It's better than yesterday," said Brunell, who wore a small bandage on the elbow. "No problems whatsoever."
In the week leading up to the Houston game, Del Rio had promised Brunell the start if he was healthy. However, with the team off to its worst start since its 1995 expansion season and Brunell likely to leave after the season, giving Leftwich game experience is starting to make more and more sense.
Brunell said after Wednesday's practice he would be healthy in time for Sunday's game.
"That will be real difficult—feeling physically ready to roll and not being able to," Brunell said. "That would be a hard one, particularly since we need a win so bad."
Making the Jaguars' week even more interesting was the return of Jimmy Smith, who served a four-game suspension for violating the league's substance-abuse policy.
The five-time Pro Bowler, who spent six weeks in rehab in South Carolina, will was activated Friday and will be back in Jacksonville's lineup as Del Rio tries to jump-start his stagnant offense.
"The staff, the organization, the players, we've all been looking forward to this," Del Rio said. "We've been supportive of what he's gone through. We're glad to have him back and we look forward to good times on Sundays with him."
The Chargers are coming off Sunday's 34-31 overtime loss to the Oakland Raiders—their eighth straight defeat dating to last season.
LaDainian Tomlinson, who leads the league in receptions by a running back with 25 and ranks fourth in yards from scrimmage (548), rushed for 187 yards, including a 55-yard touchdown run, and even threw a touchdown pass to quarterback Drew Brees.
However, San Diego's defense blew a 14-point lead late in regulation.
"When you get as many points as we had, when you get as many yards as we had, I'd like to think that we'd find a way to win," said San Diego coach Marty Schottenheimer, whose team had scored just 37 points in its first three games. "We all devote so much time and effort to it, (so) you're disappointed when you don't finish the job."
The Chargers played Sunday without receiver David Boston, who was suspended for a game by Schottenheimer for repeatedly breaking team rules.
Boston, whose $47 million contract is the largest in team history, returned to practice Monday and gave an apologetic statement to reporters, but not to his teammates. However, the Chargers didn't seem concerned that he chose not to address them.
"I think frankly, David will in his own way make his way with his teammates," Schottenheimer said. "He didn't feel like he was real comfortable doing that and I certainly wasn't going to insist that it be done."
The Chargers should have their top two receivers back for this game.
Boston went through another practice Thursday with no setbacks. Before being suspended, he had been slowed by a bruised heel.
Also, fellow receiver Tim Dwight, who missed last week's game with a strained knee, also practiced for the second straight day.
Team Comparison
|San Diego
|4th AFC West
|2-6-0 Road
|Won 1
|3rd AFC South
|5-3-0 Home
|Lost 1
Blog Coverage from SB Nation
Bolts From The Blue
Tenny Palepoi DT, Ben Beckwith G, Brock Hekking LB, Torrence Allen WR, Chris Davis CB, Chi Chi Ariguzo LB, Johnnie Troutman G, Chris Hairston T, Chris Watt C, Brandon Flowers CB, Jahleel Addae S, Jacoby Jones WR, Jason Verrett CB, D.J. Fluker T, King Dunlap T, Orlando Franklin G, Tourek Williams LB, Craig Mager CB, Stevie Johnson WR
Arrelious Benn WR, Damian Copeland WR, Dante Fowler Jr. DE, Josh Wells T, Ziggy Hood DT, Rashad Greene WR, Brandon Linder G, John Lotulelei LB


text:
8th Annual DXS Dance Xperience
Friday Aug 16, 2013
South Broadway Cultural Center
South Broadway Cultural Center
1025 Broadway Blvd SE
Albuquerque, NM 87102-4403
1025 Broadway Blvd SE
Albuquerque, NM 87102-4403
Phone: 848-1320
Website: Click to Visit
A jam-packed evening of high energy hip-hop, jazz and contemporary dance hosted by local comedienne Sarah Kennedy.
Friday, August 16th and Saturday, August 17th 7:30pm. Tickets available at holdmyticket.com or at box office. Partial proceeds benefit the New Mexico Animal Friends Organization!
Additional Dates:
Phone: 5053018800


text:
Transformers Prime the game Wii U game will guide you through all the different levels of the game.
Transformers Prime the game Wii U game will be coming out for all Nintendo consoles like the ds, 3ds, wii, and finally the wii u. this game is a action game based off the animated television show Transformers Prime that will get you going in action from the very beginning levels of the game until the end of it. Follow along the entire playthrough of the game and see how you can compete the entire game. and if your a Transformers fan you will have to check out this game for one of the Nintendo console that it comes out on. See how how transformers prime the game plays in wii u and get all the tips and tricks to completing the entire playthrough.
|Part 1
|Part 2
|Part 3
|Part 4
|Part 5
|Part 6


text:
Pixels Pencilcommented on a video on YouTube.
Awesome channel and videos!
Wondering if you could advise... I currently use a Sony alpha a200 but I feel time is right to upgrade.
I was considering the A58 until I did more research and found the other discontinued bodies such as the A37 and A57 and then found the A77ii and I'm torn with which one to invest in. The A200 has served me well and I have lots of glass so don't want to change to another camera maker such as Canon or Nikon, I've a budget between 400-800 and 800 would get me the A77ii with a memory card new and 400 would get me the A58 with three lenses and a card.
Or is there something new coming round the corner?
Thanks in advance.


text:
Sale Lightpoint Uni-Light Fixture
Now: $184.88
Compare: $217.50
+ Free Shipping100% Price Match
Pin It Houzz
Related Info
The Lightpoint places a bi-pin lamp at the end of a solid stem tube. Changes to the appearance can be made by attaching one of several accessories available. Uni-plug design allows fixture to be mounted on any Bruck lighting system or ceiling canopy through the use of an appropriate adapter (not included).
Bulbs for Bruck fixtures can be found here.
Material(s): Metal
Dimensions: Lightpoint II: 6.4"L
Lamp Type: HALOGEN, LOW VOLTAGE HALOGEN
Bulbs: 1 X 20W 12V G4 bi-pin halogen lamp (not included)
Listing: ETL
Manufacturer Specifications: Click to download specifications.
Instructions: Click to download instructions.
Model(s): 220820 220820bz 220820ch 220820mc 220830 220830bz 220830ch 220830mc
Bruck is internationally recognized as a leader in the development of innovative lighting systems with particular emphasis in the application of low voltage, halogen light sources. The pioneer of a new approach to design, Bruck places three-dimensional technology at the forefront.
Since the beginning, Bruck has been a developer and promoter of new standards in aesthetics, product quality and safety. Low voltage halogen light has evolved into one of the most highly demanded forms of lighting, finding extensive and varied applications in most styles of architecture. Much of the interior architecture of our living, working, and leisure spaces would be difficult to conceive without this brilliant, versatile, and stable light.
Sale Surface Mount Canopy With TransformerNow: $98.81Compare: $116.25+ Free Shipping
Uni-Light Wall Canopy
Note: This product is no longer available.
Sale Flat CanopyNow: $63.75Compare: $75.00
Sale Enzis AdapterNow: $38.25Compare: $45.00
Sale V/A AdapterNow: $28.69Compare: $33.75
Boa Adapter
Note: This product is no longer available.
Flex-Line Adapter
Note: This product is no longer available.
Sale High-Line Adapter H (Horizontal)Now: $38.25Compare: $45.00
Free shipping
on most orders
Expert advice
+ service
Best collection
of modern designs
Price guarantee
100% price match


text:
Deadly Rafting Accident
Posted: 07/15/2007 - Five rafters have died this summer on the Arkansas River between Leadville and Canon City.
Posted: 07/15/2007 - Five rafters have died this summer on the Arkansas River between Leadville and Canon City.
Updated: 07/14/2007 - Homeland Security Officials were in southern Colorado Saturday. They gathered at Pueblo's Transportation Technology Center to get an overview of the center's anti-terror training program.
Updated: 08/29/2007 - Three days, and no sign of a young Colorado Springs mother. A concerned family asking for help to bring her home.
Posted: 07/14/2007 - The murder of 19-year old Diontea Jackson-Forrest has not only shocked the Colorado Springs community. Folks in Gunnison are also having a tough time dealing with his loss.
Posted: 07/14/2007 - University of Colorado police are investigating threatening e-mails with anti-evolution messages sent to biology professors at the Boulder campus.
Updated: 07/14/2007 - Some Lakewood residents are complaining about noise created by a rocket testing company.
Posted: 07/14/2007 - Loveland officials first thought it was a joke, even after several people had reported seeing a large reptile in the Jayhawker Ponds.
Posted: 07/14/2007 - A unit of 25 military paratroopers mistakenly landed inside the perimeter of a state prison, but guards escorted them off the grounds with no violence.
Posted: 07/14/2007 - Thirteen-hundred new Air Force Academy cadets tested their athletic skills as well as their teamwork Saturday.
Updated: 07/13/2007 - It was a very special day for one soldier and his wife. Corporal Matthew Ortiz was on a mission in Iraq on Tuesday, the same day his first son was born. Friday, he got to see the baby for the first time.
Updated: 07/13/2007 - Every year more than 1 million cars are stolen.
Updated: 07/13/2007 - Marco Lee, the man accused of killing Colorado Springs police officer Ken Jordan, entered a plea of not guilty in court on Friday.
Updated: 07/20/2007 - U.S. News & World Report named Penrose-St. Francis Health Services one of "America's Best Hospitals."
Posted: 07/13/2007 - A North Carolina man's lifelong dream to see the Golden Gate Bridge came true this week, thanks to students at an elementary school.
Posted: 07/13/2007 - A 62-year-old woman and her 20-year-old granddaughter are recovering from injuries after a pit bull attacked them in Aurora.
Posted: 07/13/2007 - Penrose- St. Francis Health services has been named of of "America's Best Hospital" in a report published by the U.S. News & World Report.
Updated: 08/29/2007 - Major Crimes is investigating the case of a missing woman. 22-year-old Jaclyn Funderburg was last seen Wednesday night.
Updated: 07/13/2007 - Flags fly at a local home, where a family is grieving the loss of Chief Warrant Officer Three Scott Oswell, a Colorado soldier who died when his helicopter went down in Iraq last week.
Updated: 07/13/2007 - Violence and shootings following hip hop style events are now forcing Colorado Springs Police to warn parents about how dangerous these kinds of events can be.
Updated: 09/12/2012 - **Editor's Note: This story is from 2007** Two people in Southern Colorado have died after being infected by Hantavirus. One death occurred in Costilla County and the other in Custer County. The Colorado Department of Public Health says both deaths occured within the last week, but don't appear to be related.
Updated: 07/12/2007 - Health officials are warning against the threat of the West Nile Virus. Mosquitos in El Paso County have tested positive for the virus.
Updated: 07/13/2007 - With the help of google, crooks are able to crack open a safe at Bigg City and make away with $12,000. It's a story we first told you on Sunday. Now that the thieves are getting national attention, a bad situation is getting used for good.
Updated: 07/13/2007 - A Canon City soldier is laid to rest Thursday afternoon.
Updated: 07/12/2007 - Eight fellow passengers of tuberculosis patient Andrew Speaker are suing him for $1.3 million as a result of their possible exposure to the disease on a commercial flight from Prague to Montreal in late May.
Posted: 07/12/2007 - The Pentagon's top health official says there's a temporary roadblock to the Army's plans to hire 200 more psychiatrists to address growing mental health problems.


text:
Disclaimer: These superferry promos and schedules are not paid advertisements but were recently published by newspapers or through their official airline travel agencies and websites.
One Response to "2015 SuperFerry for Tagbilaran to Iligan"
irene on
September 1st, 2015 7:51 am
Mgkano poh 2go from butuan to manila this September 27..
Or may promo poh ba kau?
Got something to say?


text:
Helen Mirren and David Beckham made an unlikely pair when they met up at a banquet in Shanghai held by the British Consulate-General to celebrate the Queen's birthday. Mirren is in China for the 16th Shanghai international film festival while Beckham is there in his role as Chinese football ambassador. They make a fine couple.-TO
Helen Mirren Gets Grabby with David Beckham


text:
Beef Hamburger Steak With Sauteed Summer Squash and Refried Beans
The other night I needed a fast meal — more than that, I needed to put more fiber in front of my hubby that day…It was good enough together that he didn't even go get a bun to have with his hamburger steak!
8 comments - What do you think?
Posted by Pat Yarbrough - August 4, 2010 at 2:29 pm
Categories: American, Beef, Casein-free, Dairy-free, Dinner Menu, Egg-free, Frugal, Lactose-Free, Nut-free, Refined Sugar-free, Wheat-free Tags: celiac, gfree, gluten intolerance, gluten sensitivity, Gluten-Free, gluten-free diet, gluten-free ground beef recipe, gluten-free hamburger steak, gluten-free meal, gluten-free meals, gluten-free nutrition, gluten-free recipe, gluten-free recipes, hamburger steak recipe
Stuffed Peppers, Gluten-free and Delicious
The balance of flavors in a forkful of this never fails to entice us.
What a great gluten-free meal to pull out of the oven on a cold late winter evening!
3 comments - What do you think?
Posted by Pat Yarbrough - March 5, 2010 at 9:24 pm
Categories: American, Beef, Casserole, Dinner Menu, Egg-free, Frugal, Gluten-Free, Lunch Menu, Nut-free, Refined Sugar-free, Wheat-free Tags: gluten-free ground beef recipe, gluten-free stuffed peppers, stuffed peppers


text:
'Tha Carter V' From Lil Wayne Will Drop May 5th According To Drake [Video]
If you believe Drake, then Lil Wayne's 'Carter V' album is coming very soon.
If you believe Drake, then Lil Wayne's 'Carter V' album is coming very soon.
Rapper Drake tweeted his displeasure with Rolling Stone magazine over the cover switch and fake quote about Kanye West's 'Yeezus' album. We're not use to seeing this side of the 'All Me' rapper but it is quite interesting.
Drake offered patrons in a New York City nightclub a treat Monday night (Feb. 3). The Toronto rapper previewed two new tracks as he and French Montana were turning up at Griffin.
You can debate Drake's authenticity, but one thing that's hard to debate about him is his versatility. He can succeed in many genres, whether it's hip-hop, R&B ('Hold On We're Going Home) or pop ('Find Your Love'). But the question remains: Can he do bachata? OK, that's not really a burning question, but it's nice to know he is decent in that area. The Toronto rapper connected with Bronx, N.Y.'s Romeo Santos for 'Odio' -- which means Spanish for hatred.
Drake is among a bevy of rappers who will be vying for a win at the 2014 Grammy Awards this Sun., Jan. 26. The Toronto rapper knows what it's like to win a golden gramophone after nabbing one for Best Rap album (for 'Take Care') in 2013. However, he says that winning a Grammy doesn't make or break him as an artist.
The 2014 Grammy Awards are just around the corner. The "biggest night in music" honors the best of the best, but hip-hop and R&B have traditionally been overlooked by the awards the show. Th...
If you are tired of looking at your phone to see the weather you can go to Drakeweather.com.
Drake is hosting and serving as the musical guest of 'SNL' this weekend (Jan. 18), a popular trend this season, with Miley Cyrus and Lady Gaga recently pulling double duty.


text:
Lesbian woman, 35 years old from Floreda, United States
- About me
- Videos (1)
- Favorites (15)
- Comments
- Share
xTip: Sending a positive vote will save this user to your account, like a personal bookmark. Additionally, they will see this vote and may like you back, which will allow the exchange of your private contact information.
Signed up: September 13th, 2012 (1120 days ago)
Profile hits: 4,400
Subscribers: 36
Total video views: 71,920
Gender:Lesbian woman
Age:35 years old
Country:United States


text:
Anamar Suites
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Swimming pool
- Restaurant
Travelers also recommend:
TripAdvisor Reviews Anamar Suites Playa del Ingles
Travel Blogs from Playa del Ingles
10 Things To Do In Gran Canaria During Winter
... s an assortment of more laid-back nautical activities - think catamaran trips, a glass-bottomed boat excursions, or even booze cruises.
9. Take a hike at Pico de las Nieves
If it's a hiking challenge you're after, hit the trails of Pico de las Nieves. It's the island's highest mountain, grazing clouds to reach 1,949 metres into the sky. Or, if you'd prefer a slightly less strenuous trek, you can stroll around the pine forest at Tamadaba National ...
Canary Smugglers
... interesting and inspiring woman, battle hardened and highly educated, well worth a google. 1599 saw Frances Drake defeated. The Dutch then made a strong campaign, successfully conquering the city of Las Palmas but not quite the whole island, holding the entire territory only for a short time until losing it to guerrilla forces. Later, Admiral Nelson claimed Gran Canaria as part of the British Empire in the 19th Century, and so this push and pull of cultural influences ...
Cruise - Day 7
... to the Madeira blog *yay* In the afternoon, we headed to the beach and had some lunch in one of the beachside restaurants. It was very warm but very windy so it didn't feel too hot. Unfortunately we both burnt. We re-embarked ahead of the sailing time and I headed to deck 18 to join my friends. The boys kicked a football overboard, so before sailing, the Environmental Officer had to ...
Las Palmas
DAY 14 - March 26, 2015
Our third stop in the Canaries ... Las Palmas .... the 5th largest city in all of Spain ... and a beachside resort alongside a bustling city.
In fact the beach is right in ...
Christmas on the islands
... stayed in with no blinking lights. I took a nice nap and then we packed up our big suit cases. The bikes, vans and big suit cases will all travel tonight on a ferry over to Tennerife. We went to the pool for afternoon tea time. Merry Christmas sitting in the sun enjoying tea is amazing. Tonight was dinner on our own so we ordered room service early and had delicious fish and filet. It was early bedtime since we have to meet at 5:45 am and I want to feel ...