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OSI-Approved Open Source (12)
- GNU General Public License version 2.0 (6)
- MIT License (5)
- BSD License (3)
- GNU General Public License version 3.0 (3)
- Apache License V2.0 (2)
- GNU Library or Lesser General Public License version 2.0 (2)
- Adaptive Public License (1)
- Artistic License (1)
- Common Public Attribution License 1.0 (1)
- GNU Library or Lesser General Public License version 3.0 (1)
- Creative Commons Attribution License (1)
- Other License (1)
- Mac (46)
- Modern (35)
- Linux (17)
- Windows (14)
- Grouping and Descriptive Categories (11)
- Other Operating Systems (7)
- Embedded Operating Systems (6)
- Emulation and API Compatibility (4)
Top Apps
- Audio & Video
- Business & Enterprise
- Communications
- Development
- Home & Education
- Games
- Graphics
- Science & Engineering
- Security & Utilities
- System Administration
Smart C++ Builder
Simple But Powerful VIM Based Build Environment With Flex & Bison17 weekly downloads
TDM-GCC MinGW Compiler
GCC for 32-bit and 64-bit Windows with a real installer & updater16,881 weekly downloads
A collection of open source and public domain software for Java, XML, and Cocoa, primarily. Some projects: ThreadWorker, Xmlizable, Base64, Tabu Search.283 weekly downloads
Appscript is a high level, user-friendly Apple event bridge that allows you to control scriptable Mac OS X applications from Python, Ruby and Objective-C. Appscript makes these languages a serious alternative to AppleScript for automating your Mac.4 weekly downloads
Crosos Operating System
Crosos is a SubLinux Distribution0 weekly downloads
A resource editor for the Mac OS.14 weekly downloads
iSlider Game
A simple Iphone game that uses different UI elements and events.2 weekly downloads
Meteorologist is a free weather program for OS X. It allows users total control over their weather viewing, including simultaneous interlaced weather reports from multiple weather servers, multiple weather locations, weather alerts and much more.187 weekly downloads
Project Silver
A Open Source Social Network1 weekly downloads
What's Open
A simple utility for MacOSX which lists the open files on a system and allows the user to kill the process that has them open. A handy search feature allows you to find things quickly.2 weekly downloads
RIT Code
RITCode is an analysis tool for captured eye tracker video files. It allows the scientist to analyze eye movements and characteristics of the scene. It has been created by the Rochester Institute Of Technology Visual Perception Lab.0 weekly downloads
Mac News
This is a program that allows binary posting to binary newsgroups for the mac os-x software and is intended to be used by less than experts.0 weekly downloads
A collection of custom controls, helpful libraries and general utilities for iPhone development.0 weekly downloads
chmosx is a chm reader for Mac OS X 10.5 (Intel). Main features: Multiple ways to navigate the pages in a chm document. Search document or page. Full screen support. Apple Remote Control support. Bookmarks manager. Tabbed documents. Converter to PDF15 weekly downloads
NXT Controller
This project is a tool (soon) and an application to control a NXT Brick from Lego, over Bluetooth (and eventually USB, but it's not supported yet). This is only for Mac OS X.4 weekly downloads
VulcanDepot Environment
The 3d Default: One computer room, a utility room, and living space, optional outdoors. The computer room should simulate. Utility-room: 3d-designed actions. Living space for designs andor avatar use.0 weekly downloads
Jefferson Internet Browser System (JIBS)
A browser designed for social networking and casual internet users. Very small and stripped down.1 weekly downloads
Vitality is a project that aims to provide a home to a few open source Mac games that are currently without one.5 weekly downloads
Xamp - In-car multimedia front end (Mac)
xamp is an opensource project with the aim of providing a full-featured in-car front end for MAC OSX. xamp is based off of the original AMP source code by Aychamo on the mp3car.com forums.2 weekly downloads
uDevGames 2008 Games and Source Code.0 weekly downloads
It is a group of projects while is available on iPhone or Symbian_OS_Device.0 weekly downloads
MD5 Password Recover
Recovers your password that has been MD5 Hashed on Mac OS X0 weekly downloads
Four20 is an Objective-C library for iPhone developers, providing a few 'extras' the Three20 library neglected0 weekly downloads
FormaFixer is a tool for using in chemical production.0 weekly downloads
Epsilon Render Framework
This is a personal project that I started after leaving my previous job, where I oversaw the development of an in-house 3D engine for online gaming. Epsilon refers to "almost nothing reused," and is designed around rapid throw-away prototyping.0 weekly downloads


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Why the U.S. Owns the Rise of Islamic State and the Syria Disaster
Climate Change Tipping Points and the Question of Civilizational Survival
What Is Russia's Strategy in Syria and Why Does Egypt Approve?
VIDEO: Trevor Noah on Ben Carson's Genius Plans to Deal With Mass Shootings
Risk of Global Financial Crash Has Increased, IMF Warns
By William Pfaff $16.50
Richard Reeves $4.33
Christopher Weyant, Cagle Cartoons, The Hill —
AP / Saul Loeb
So the official story here is that President Obama says he wants to cut the country's corporate tax rate by seven percentage points, dropping it from 35 percent to 28 percent, which gives him a nice tax-related headline on a day when similar stories are cropping up about the competition.
Luojie, Cagle Cartoons, China Daily, China —
Although the outcome of this fall's midterm elections didn't suggest great possibilities for the last two years of President Obama's term, he would like to suggest, as he does in this speech after Wednesday's START vote, that ...
This week's episode of "Left, Right & Center" features a double dose of commentary from the right, making the conversation about Obama's strategy in Afghanistan, the death of Richard Holbrooke, the future of health care reform, the Financial Crisis Inquiry Commission's findings ...
In Internet-ese, one possible response to a couple of President Obama's more intriguing justifications on Friday for the passing of the contentious tax-cut bill might be O RLY? This is because the president declared later that same day ...
AP / J. Scott Applewhite
The sight of Bill Clinton back at the White House podium defending tax cuts for the super-rich was more a sick joke than a serious amplification of economic policy.
Wikimedia Commons / United States Senate
California Sen. Barbara Boxer is one of a group of purportedly left-leaning politicians who is choosing to throw in with President Obama in his plan to preserve Bush-era tax cuts that give the wealthy a break along with Americans hailing from lower-income brackets.
Wikimedia Commons / Scrumshus
That pronounced blast of disapproval from the left-leaning ranks in the House of Representatives last week may not be enough to blow President Barack Obama's tax-cut proposal down, as the Senate gave it a strong vote of confidence Monday.
From the "White House White Board" to Glenn Beck's blackboard, it seems like everyone's trying to spell out fundamental political concepts using methods usually reserved for elementary school teachers. Does this say something about their opinions of American voters?
What are we to make of Obama's concessionary tax-cut move this week? Politically savvy or just another sign that what some of us bought isn't what we got in our president? There's definitely some disagreement about this point among the panelists ...
This just in: The rich get richer. President Barack "Hope 'n' Change" Obama ticked off a lot of people Monday by helping the affluent and entitled stay that way with his GOP-appeasing tax cut plan ...
Wikimedia Commons / U.S. House of Representatives
According to a clearly disapproving Rep. John Boehner, the House of Representatives' vote Thursday in favor of keeping tax cuts for people earning less than $250,000 a year was tantamount to "chicken crap."
AP photo / Gene J. Puskar
Let me now defend white males. We can't possibly be as dumb as the polls showing we are John McCain's most reliable voting base would indicate.
From "The Colbert Report" via crooksandliars.com
The "Colbert Report" warmly appreciates the wonderful people who voted against their interests and gave people like its host a tax break. | video
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Tuesday, 6 October 2015
Last updated 1 hour ago
Sep 14 2012 | 10:43am ET
A San Francisco hedge fund manager has won approval to build a sports arena in his hometown of Seattle, to which he hopes to attract a basketball team.
Seattle's City Council this week gave its assent to the planned $490 million project, including a city contribution of $200 million, using tax revenues the building generates.
It wasn't easy to win the OK, which will formally come on Monday: Christopher Hansen, who heads Valiant Capital Management, had to accept a renegotiated memorandum of understanding that requires increased protection for taxpayers and further studies and investment in the transportation infrastructure in the neighborhood that will house the arena, which is already home to baseball's Seattle Mariners and football's Seattle Seahawks.
Under that new MOU, Hansen has personally guaranteed bond payments if arena revenues can't cover them and could have to buy the arena in 30 years for $200 million.
With the deal in hand, Hansen is now on the lookout for a team to put in his new arena.
"It means a lot to the" National Basketball Association, Hansen said. "They've been watching very close to what we're doing. I think going in they were very skeptical we would get to this point given our history in Seattle."
Hansen said that while he thought it was "conceivable" that Seattle could have a team next year, he's not holding his breath.
"I worry that people are expecting us to get this deal done and it be like magic and a team would be here this year," Hansen explained. "It's like, 'Poof and we've got a deal done and where is our team?' This is a far more difficult process."
Oct 5 2015 | 8:17pm ET
Hedge fund administration has evolved from simple record keeping to an integral,...
Sep 16 2015 | 3:04pm ET
Never count hedge funds out of a big property deal. The Manhattan real estate market...
Sep 30 2015 | 1:56pm ET
In this contributed article, Bruce Frumerman of Frumerman & Nemeth Inc. explains...
May 27 2015 | 2:15pm ET
Support Hedge Funds Care, also known as Help For Children (HFC), by participating in this year's raffle. All proceeds go to support HFC's mission of preventing and treating child abuse. Read more…


text:
White-hat hackers use their powers for good. They help out organizations that might have security breaches before the organizations get hacked. Hacking doesn't always mean hacking into someone else's system.
"The use of 'hacker' to mean 'security breaker' is a confusion on the part of the mass media," said Richard Matthew Stallman, a well-known white-hat hacker and software developer. "We hackers refuse to recognize that meaning, and continue using the word to mean someone who loves to program, someone who enjoys playful cleverness or the combination of the two."
TUTORIAL: Investing 101
Tim Berners-Lee
Famous not for hacking but inventing the World Wide Web, Berners-Lee nevertheless is undeniably a member of the white-hat hacking camp. As a student at Oxford University, Berners-Lee was banned from using the university computers after he and a friend were caught hacking to gain access to restricted areas. He moved on and built his own computer from spare parts. After college, he hacked a few other things including HTML. Did we mention creating the World Wide Web? (For related reading, see Most Costly Computer Hacks Of All Time.)
Steve Wozniak
The "other Steve" of Apple, Steve Wozniak got started as a white-hat hacker by making something called blue boxes. Wozniak and Jobs built blue boxes, which essentially hack the phone system so users can make free long-distance calls. They then sold the blue boxes to their classmates in college. Of course, you know the rest of the story. From blue boxes they moved on to bigger and better things. Those early days of white-hat hacking are what started them off.
Kevin Mitnick
Mitnick started as a black-hat hacker, and ended up serving time after hacking into some of the biggest companies in the world. Now he has left the dark side and works as a consultant and a writer. His own hacking experience gives him hands-on expertise. An article by TakeDown.com reports that Mitnick's early hacking days were ambitious and largely successful.
"As a teenage prank in 1982, he allegedly broke into a North American Air Defense Command computer in Colorado Springs, Colo. He once altered a phone program to misdirect federal agents trying to trace his call, sending them barging into the home of a Middle Eastern immigrant watching television," states the article. We're all glad he's on the good side now.
Tsutomu Shimomura
Back in the days when Mitnick was a black-hat hacker, he hacked computer-security expert, Shimomura. This didn't go over well. Shimomura decided to take his own revenge by using his hacking skills to assist the FBI in tracking and locating Mitnick. With Shimomura's help, they were successful, and Mitnick was arrested. Now they're on the same team. (For related reading, see Identity Theft: Who To Call For Help.)
Jeff Moss
Moss is better known in the computer world as Dark Tangent, though he's now well known apart from his hacking handle. Moss founded the Black Hat security conferences, which still draw thousands of computer security experts. Moss also founded Defcon, which is a hugely popular annual hacker conference. He serves as the chief security officer for ICANN and as an adviser to the U.S. Department of Homeland Security. He continues to run the Black Hat security conferences and Defcon.
Jon Lech Johansen
Even though they often help big companies protect themselves from malicious hackers, white-hat hackers are far from being passive cogs in the system. White-hat hackers often embrace the independent and the free sharing of resources such as open source, open access, and free sharing of software and protocols.
Like Wozniak building boxes to allow college peers to get free long distance phone calls, Johansen is a younger, newer hacker who has used his skills to aid others in beating a closed system. His hacking skills enabled him to hack an encryption system used on DVD movies. As a result, users of Linux or other open source operating systems are able to play DVDs encoded with Microsoft's proprietary codec, which is supposed to prevent non-Microsoft systems from running the DVDs.
TUTORIAL: Stock Basics
Richard Matthew Stallman
Stallman founded the GNU Project. The GNU project is both an open source operating system and a mass collaborative project. According to Stallman, GNU includes programs that are not GNU software but rather programs that were developed by other people for their own purposes. Stallman continues to work on the GNU Project and is an advocate for free and open software.
The Bottom Line
White-hat hacking has become more and more important as businesses and individuals depend on computers and the internet. Since computer security isn't something all of us understand, it's vital to have those who do share their expertise. (For related reading, see Cybercrime The Newest National Threat.)
Why Some Celebs Say 'No Inheritance for My Kids'To some of the super rich, inherited wealth is not the ultimate gift, it's a burden. Here's how their children—as well as charities—stand to benefit.
Kevin O'Leary BiographyKevin O'Leary is a television personality, businessman and investor from Canada. A brash public personality with a net worth of roughly $300 million, he is considered to be the Canada's answer ...
7 Top-Earning Child StarsThese seven top-earning child stars earned millions through different parts of the entertainment industry, including television, film and music.
8 Top-Earning Country SingersThese eight country singers have built careers singing about men and women who've done them wrong, and they've shared their heartache to the tune of millions of dollars.
Elon Musk Success Story: Net Worth, Education & Top QuotesRead more about Elon Musk, the South African immigrant turned technology and engineering entrepreneur and inventor worth $13.6 billion.
Investing News
How 'Honesty' Could Pay off for Jessica AlbaIs it possible that Jessica Alba is one of the savviest businesswomen on the planet?
Investing News
Famous Celebrities Who Love InvestingCelebrities have a bit of a bad reputation these days. These five celebrities, though, have used their fame and their money to invest successfully instead of spending it on looking good.
The Top 5 Richest RestaurateursThe top five richest restaurateurs have proven that it is possible to not only turn a profit in the restaurant business but to become multi-millionaires!
The Top Six Richest SupermodelsThrough excellent investing, brand management and high earnings, these six supermodels have cultivated multi-million dollar net worths.
Investing Basics
10 Reasons Google Is One Of The Best EmployersFind out more about Google Incorporated and reasons why Google was named to Fortune magazine's list of the best companies to work for.
What is the relationship between research and development and innovation?Although it's possible to achieve innovation without research and development and it's possible to conduct research and development ... Read Full Answer >>
What are some common functions of business intelligence technologies?Although business intelligence technologies have some common functions, their main function is to support a company's decision-making ... Read Full Answer >>
What is the difference between an MIS (Management Information System) and Information ...Management information system (MIS) refers to a larger infrastructure, whereas information technology (IT) is one component ... Read Full Answer >>


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Changes related to "1994-05-27 Oscar De La Hoya w rtd 3 Giorgio Campanella, MGM Grand, Las Vegas, Nevada, USA - WBO"
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold.
No changes during the given period matching these criteria.


text: Hey folks- A quick note to let you know of a few updates. I shortened my business brand name to 33stew. It's just easier to say, to type, and to share. I have also updated the website. 33stew.com. It reflects the new work and the new direction i have gone in in the last year or two. Change is good. Feel free to check out some of my new work and thanks for supporting me in the past. Visit 33stew.com for more info. Cheers. Sean


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Additional file 4.
Schematic representation of the genes diversely conserved in R. africae in comparison with highly pathogenic rickettsiae. The state of a gene is represented by a small box colored in green (full-length), blue (pseudogene), red (fragment), orange (remnant) or black (absent).Gene numbers are indicated in the left column. The Figure shows the gene distribution in R. africae by comparison with highly pathogenic rickettsiae.
Format: PPT Size: 113KB Download file
This file can be viewed with: Microsoft PowerPoint Viewer
Fournier et al. BMC Genomics 2009 10:166 doi:10.1186/1471-2164-10-166


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Ocean& Mtn Views! Retreat haven!United StatesCaliforniaLos Angeles
About this listing
Space where guests can cook their own meals
Towels, bed sheets, soap, and toilet paper
The Space
Please see listing number 240623 for excellent references on THIS property. This is a new listing and references don't transfer. Welcome to the legendary community at the top of Palisades Drive in Pacific Palisades. Though we're only a few minutes away from the bustle of Los Angeles life, our home is your retreat. With our spectacular ocean and mountain views, the peace and quiet our homeowners enjoy combined with the neighborhood amenities and proximity to Los Angeles ensure strong property values and a great quality of life.
Our neighborhood is a collection of 200 single family residences in a variety of configurations from custom-built dream homes featured in architectural magazines and elite real estate publications to large four- to six-bedroom designs. Our multi million dollar organic "green" 6,000 square foot home boasts ocean and mountain views. Our climate often is as much as 25 degrees warmer than sea level 1700 feet down the mountain. We are majestically situated above the ocean layer of fog enjoying more sun than the beach 5 minutes away. unlike many hilltop communities, our area is serviced by a four lane highway with speeds ranging from 25 to 45 M.P.H.
Our home is known for it's attention to detail. Amenities include:
• 2 minutes to trailheads in Topanga State Park and the famous Skull Rock and Temescal Waterfalls
• safe, serene area that's 24 hr armed patrolled.
• custom home with limestone floors and crown moldings,
•5 fireplaces, koi & turtle ponds, strong jet spa with drink holders and speakers built into the rock waterfalls surrounding it!
• Central heating and air conditioning
• Whole house water and HEPA filter system-drink the tap water
•EMF free environment
• High speed internet, cable TV, Sirius XM music
•Unlimited parking
This is a great opportunity to become part of exclusive area! Walk around the block and you're bound to run into someone you see on TV.
Please note this is a Non Smoking Property.
We encourage you to take advantage of our amazing chef quality Organic Meals partially made from our organic garden. We welcome you to pick and eat out of our beautiful organic gardens.
Let this be your home away from home! •
and we'll wash your clothes for a minimal fee!
•Situated 5 minutes from the beach where Baywatch was filmed!
15 minutes to UCLA, Pepperdine, SMC & Santa Monica Promenade.
30 minutes to LMU & USC. •
Other Things to Note
Please note there is a 14% LA City Transient Occupancy Tax that is mandatory for all people renting such as hotels and people on Airbnb. It will be collected separately or can be added as an Special Offer. Weekends, summer and holidays may be subject to a 10% to 30% upcharge.
We require guests who book through Airbnb to sign a rental contract. Refusal to sign the contract will result in cancellation of your booking.
The house rules are no smoking anywhere inside and outside only in designated area in backyard.
Each room is rented at the nightly rate. I have 4 rooms to rent. Additional people in the room are charged $50. Children under three years old in the same room with parents are free.
No dogs allowed upstairs, in beds or on furniture.
Shoes must be left by the front door in baskets.
Turn off the lights when you leave the room
Do NOT feed any of the animals at the table or anywhere else (they have dog runs if you are not an animal person).
Shut the toilet when you finish your business! MEN SIT DOWN to urinate . Think of it as a nice rest….I WILL KNOW if you stand! lol
About the Host, Michelle
Hello there! I have never met a stranger. Walk in my front door and you are my friend. My friends call me Martha West…Wait, the good parts! Entertainer, great cook, more knowledgeable in construction that Martha East, and gardener! Both of my parents, my grandmother and her mother are Los Angeles natives! I have never lived more than one hour from my crib so who better to tell you about this great city?
I love to travel and have been to many of the finest resorts in the world. So I know what great service is and provide it to all of my guests. From flowers in the room to fresh cucumber or mint in the water, it's the details that count.
I love all music and love to dance. I am always bopping to the music and play it all the time. From Top 40, house music to light classical , whatever your mood, I will play it.
I am very playful and very young at heart. Stay in my home and you will want to return soon and recommend your friends! Many of the photos are taken at parties that I have thrown so you get an idea of what we are all about here.
I am a USC Alumni and my son is there now and I am an avid fan. I love playing, watching and coaching sports. We have the set up for game day here on surround sound stereo, outdoor TV's and all that jazz.
I strive to live a clean, organic lifestyle and it is reflected in my food, home and the zen of this property. And if you get bored with all of this peacefulness, I can take you out on my boat and rip around the water. For a unique, life changing experience, come spend some time in my home. You'll be glad you did! :D


text:
Double Shot #1560
Friday, October 2, 2015 at 5:47AM
- Do not let your CDN betray you: Use Subresource Integrity - Something else I probably should look into during my copious spare time.
- Classic Bug Reports - Jokes, detective stories, and arguments in various bug-trackers.
- Deppbot - Service to automate updating your bundled gems. Best used in conjunction with an automatic CI service.


text:
We use cookies to optimise your experience on Travelzoo. By using our website, you are agreeing to allow this. For more information, see our Privacy & Cookie Policy »
Not available on: Nov. 27-30; Feb. 13-14. Purchase a voucher from Travelzoo then call the hotel directly at 1-800-570-3932 to make a reservation for your desired travel dates. Based on double occupancy. Additional adults are CA$30 per night. Up to two children 16 years of age and younger are free. One-bedroom suites accommodate up to three guests; two-bedroom suites accommodate up to six guests. Parking is included. This hotel is pet-friendly. A nightly fee of CA$25 for pets will apply. Reservations are subject to availability and early booking is encouraged.See all terms
M – F, 9am – 9pm ET
|Enjoyed Most
|Other Comments
Convenient location for us.
The heater was noisy but did not use as warm night. Everything else was in good condition. Comfortable bed and linens.
|Apr 22, 2015 Jonathan Washington, United States
It was close to many downtown attractions.
We also enjoyed the complimentary bottle of wine.
|Apr 20, 2015 MARY AZ, United States
The view from our room was nice, the complimentary bottle of wine and the soap in the bathroom was great!
I was told that a bottle of wine and glasses would be waiting for us in the room. There were no glasses. It took the staff 45 minutes to bring some up. I found a old food tray filled with dust over hiding on top of our mini fridge. I thought during the wine reception there would be staff that knew something about the wine selection but the staff couldn't answer any questions. Also I dont mind parking and getting my own car but with that over priced parking fee being wavered, I would think there would be at least valet. Lastly I had to go downstairs and request towels for the hot tub. Both times we went to the hot tub, the towel bins were empty.
|Mar 23, 2015 Juliet Washington, United States
older, but clean
|Mar 23, 2015 Manfred Washington, United States
Convenient location, good breakfast and free Wi-fi
|Mar 17, 2015 Corbin Washington, United States
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text:
Troy replied on Permalink
My wife was diagnosed about 2.5yrs ago and has continued to get worse since. She has been on 20+ different types of meds, involuntarily admitted 2 times, and just keeps cycling. Sometimes she can admitt she is sick, other times, she thinks its everyone else. The hardest part in getting her to co-operate with treatment, and not continue to hurt everyone around her. I met her when she was 19 (now is 35) and she had signs of manic and depression then. I hope there is development some day for early detection and treatment to prevent the condition from taking over lives. She has made attempts on my life and hers, and tried to abduct our son several times. Now I must spend thousands to try to keep my son and myself safe, and there is no guarantee I will win.
I would love to see more early education around mental illness so maybe some can get treatment sooner and live healthy, productive lives.


text:
THIS RESOURCE IS NO LONGER IN SERVICE, documented on 8/12/13. Database to access and mine alternative splicing information coming from genomics and proteomics based on genome-wide analyses of alternative splicing in human (30 793 alternative splice relationships found) from detailed alignment of expressed sequences onto the genomic sequence. ASAP provides precise gene exon-intron structure, alternative splicing, tissue specificity of alternative splice forms, and protein isoform sequences resulting from alternative splicing. They developed an automated method for discovering human tissue-specific regulation of alternative splicing through a genome-wide analysis of expressed sequence tags (ESTs), which involves classifying human EST libraries according to tissue categories and Bayesian statistical analysis. They use the UniGene clusters of human Expressed Sequence Tags (ESTs) to identify splices. The UniGene EST''''s are clustered so that a single cluster roughly corresponds to a gene (or at least a part of a gene). A single EST represents a portion of a processed (already spliced) mRNA. A given cluster contains many ESTs, each representing an outcome of a series of splicing events. The ESTs in UniGene contain the different mRNA isoforms transcribed from an alternatively spliced gene. They are not predicting alternative splicing, but locating it based on EST analysis. The discovered splices are further analyzed to determine alternative splicing events. They have identified 6201 alternative splice relationships in human genes, through a genome-wide analysis of expressed sequence tags (ESTs). Starting with 2.1 million human mRNA and EST sequences, they mapped expressed sequences onto the draft human genome sequence and only accepted splices that obeyed the standard splice site consensus. After constructing a tissue list of 46 human tissues with 2 million human ESTs, they generated a database of novel human alternative splices that is four times larger than our previous report, and used Bayesian statistics to compare the relative abundance of every pair of alternative splices in these tissues. Using several statistical criteria for tissue specificity, they have identified 667 tissue-specific alternative splicing relationships and analyzed their distribution in human tissues. They have validated our results by comparison with independent studies. This genome-wide analysis of tissue specificity of alternative splicing will provide a useful resource to study the tissue-specific functions of transcripts and the association of tissue-specific variants with human diseases.
URL: http://bioinfo.mbi.ucla.edu/ASAP/
Resource ID: nif-0000-33105 Resource Type: Resource Version: Latest Version
gene, genome, human, isoform, mechanism, metazoa, molecular, mrna, nucleus, process, protein, sequence, splice, tissue specificity, transcription, transcript, alternate splicing, microarray, alternative splicing, biological process, alternatively spliced isoform, contig, cancer, image
human, mouse
Alternative Splicing Annotation Project II Database
Alternative Splicing Annotation Project, Alternative Splicing Annotation Project database, Alternative Splicing
THIS RESOURCE IS NO LONGER IN SERVICE, CCB License
No Changes
Recently, genomics analyses have demonstrated that alternative splicing is widespread in mammalian genomes (30-60% of genes reported to have multiple isoforms), and may be one of their most important mechanisms of functional regulation. However, by comparison with other genomics data such as genome annotation, SNPs, or gene expression, there exists relatively little database infrastructure for the study of alternative splicing. We have constructed an online database ASAP (the Alternative Splicing Annotation Project) for biologists to access and mine the enormous wealth of alternative splicing information coming from genomics and proteomics. ASAP is based on genome-wide analyses of alternative splicing in human (30 793 alternative splice relationships found) from detailed alignment of expressed sequences onto the genomic sequence. ASAP provides precise gene exon-intron structure, alternative splicing, tissue specificity of alternative splice forms, and protein isoform sequences resulting from alternative splicing. Moreover, it can help biologists design probe sequences for distinguishing specific mRNA isoforms. ASAP is intended to be a community resource for collaborative annotation of alternative splice forms, their regulation, and biological functions. The URL for ASAP is http://www.bioinformatics.ucla.edu/ASAP.


text:
Today's Catch
May 22, 2015
A behind the scenes look at the NMNH ocean-related collections and their importance to research and discovery.Read more
May 21, 2015
This fossil tooth whorl of the ancient shark Helicoprion , dates back 290 million years. For a long time, people didn't know what the shark looked like—but, thanks to a CT scan of a fossil, researchers finally put the pieces together in 2013. Read more about this story in our great white shark overview , and learn more about top predators like Helicoprion in the Ocean Over Time section .Read more
May 20, 2015
A huge colony of brittlestars (likely Ophiacantha rosea ) covers the peak of a seamount in the deep ocean. What's the attraction? Food! Their arms reach out for tiny food particles carried by the swift Antarctic Circumpolar Current. More about the deep ocean can be found in the Deep Ocean Exploration section .Read more
May 19, 2015
"As we motored around Paulet Island in a Zodiac boat, these two curious penguins waddled across an iceberg to get a closer look at us." -- Nature's Best photographer, Phillip Colla . See more beautiful ocean photos in our slideshow of winners from the 2010 Nature's Best Ocean Views photo contest. These Adélie penguins live in Antarctica and rely on tiny crustaceans, called krill, as their main...Read more
May 18, 2015
This copepod Calanus hyperboreus (up to 7mm in length) lives in the Arctic , usually within 500 meters of the surface. To survive the cold Arctic winters, Calanus hyperboreus builds up dense fat (lipid) supplies on its body, which makes it a preferred food of both ctenophores and bowhead whales.Read more
May 15, 2015
Florida Manatee ( Trichechus manatus latirostris ) swimming within a fresh water spring on Crystal River in Florida. Note the tree roots on the right of the frame which make up a portion of this unique ecosystem. Fish aggregate around the manatee and eat algae off of the manatee's body.Read more
May 14, 2015
Nancy Knowlton, Smithsonian's Sant Chair for Marine Science, puts up an Autonomous Reef Monitoring Structure (ARMS) during a dive in the Red Sea. These small underwater "condos" have been placed across the world's oceans—from shallow water to 700 feet on the deep reefs of Curaçao, and from Brazil to the Indian Ocean. The ARMS mimic the nooks and crannies of oyster reefs, without the sharp edges...Read more
May 13, 2015
Deep-sea corals miles away from the source of the Deepwater Horizon oil spill in 2010 were impacted by the plumes. One affected site was 13.7 miles (22 km) away from the Macondo wellhead—the farthest observed—and extremely deep, more than 6,000 feet (1,875 meters) below the surface. This is deeper than any of the reported oil plumes that resulted from the spill. How did oil get down there? Read...Read more
May 12, 2015
Two California market squids ( Loligo opalescens ) mate in the waters off of California's Channel Islands. While spawning, the male's arms blush red as he embraces the female, a warning to other competing males to back-off. Find out how and why squids and other cephalopods change color .Read more
May 11, 2015
"A four-foot-long barracuda is visible flashing past me, with the sky and the lights of my boat seen above." -- Nature's Best photographer, Yeang H. Ch'ng. See more beautiful ocean photos in our slideshow of winners from the 2010 Nature's Best Ocean Views photo contest.Read more


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