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An electrifying band with influences from each member that round the band off to give it an endless genre defining sound. Fusion with sounds of rock, jazz, classical, r&b, and punk that pull it all together giving the band endless possibilities. Accompanied by lyrics that motivate the mind to start a revolution, fall in love, or just dance, this music has a fresh young sound, a touch of old, and a bring-in-your-face attitude.

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Page 1
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 2007, p. 1934–1938
0066-4804/07/$08.00?0 doi:10.1128/AAC.01028-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Vol. 51, No. 6
Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn
Wound Model?
Catherine S. McVay,† Marisela Vela ´squez,‡ and Joe A. Fralick*
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas
Received 16 August 2006/Returned for modification 21 November 2006/Accepted 17 March 2007
Mice compromised by a burn wound injury and subjected to a fatal infection with Pseudomonas aeruginosa
were administered a single dose of a Pseudomonas aeruginosa phage cocktail consisting of three different P.
aeruginosa phages by three different routes: the intramuscular (i.m.), subcutaneous (s.c.), or intraperitoneal
(i.p.) route. The results of these studies indicated that a single dose of the P. aeruginosa phage cocktail could
significantly decrease the mortality of thermally injured, P. aeruginosa-infected mice (from 6% survival without
treatment to 22 to 87% survival with treatment) and that the route of administration was particularly
important to the efficacy of the treatment, with the i.p. route providing the most significant (87%) protection.
The pharmacokinetics of phage delivery to the blood, spleen, and liver suggested that the phages administered
by the i.p. route were delivered at a higher dose, were delivered earlier, and were delivered for a more sustained
period of time than the phages administered by the i.m. or s.c. route, which may explain the differences in the
efficacies of these three different routes of administration.
Pseudomonas aeruginosa plays a prominent role as an etio-
logical agent of serious infections in patients with burn
wounds. Acute burn wounds cause a breach in the protective
skin barrier and suppress the immune system, rendering the
patients highly susceptible to bacterial infection. P. aeruginosa
colonization of severe burn wounds and its rapid proliferation
within the damaged tissues often lead to disseminated infec-
tions, resulting in bacteremia and septic shock (8, 20) and high
rates of mortality and morbidity. Treatment of such infections
is confounded by the innate and acquired resistance of P.
aeruginosa to many antimicrobials (8, 15). It has been esti-
mated that at least 50% of all deaths caused by burns are the
result of infection (8), and untreatable infections have become
a tragically frequent occurrence in patients infected with P.
aeruginosa (9). Hence, the development of new therapeutic
and prophylactic strategies for the control of bacterial infec-
tion in patients with burn wounds is needed.
An alternative or supplement to antibiotic therapy, which is
currently being reexamined, is the use of bacterial viruses
(phage/bacteriophage) to target bacterial infections, i.e., phage
therapy (13, 16–18, 22, 29, 30–32). Soothill examined the ability
of bacteriophage to prevent the rejection of skin grafts of
experimentally infected guinea pigs (27). His findings demon-
strated that the phage-treated grafts were protected in six of
seven cases, while untreated grafts failed uniformly, suggesting
that phage might be useful for the prevention of P. aeruginosa
infections in patients with burn wounds. However, while mul-
tiple studies have demonstrated the benefits of phage therapy
for a variety of bacterial infections in animal model systems
(3–7, 10, 14, 19, 23–26, 33–35), little documentation exists with
regard to the treatment of burn wound infections (2). In the
study described here we used the mouse model of thermal
injury (28) to examine the efficacy of phage therapy in abro-
gating fatal P. aeruginosa infections. These studies include the
examination of different routes of phage administration.
(This work comprised part of Marisela Velasquez's require-
ments for the master of science degree.)
Bacterial strains, bacteriophages, and culture conditions. PAO1Rifis a
rifampin-resistant derivative of virulent P. aeruginosa strain PAO1 (12), which
was kindly provided by Abdul Hamood (11) and which was grown in Luria-
Bertani (LB) medium supplemented with rifampin (80 ?g/ml), 1 mM MgSO4,
and 1 mM CaCl2in a gyratory shaker at 250 rpm at 37°C.
The P. aeruginosa phages were plaque-purified subcultures of phages that had
been purchased from the American Type Culture Collection (Catalogue of
bacteria and bacteriophages, 18th ed., 1992; ATCC, Manassas, VA). Monophage
preparations were propagated on their respective hosts growing in LB medium at
37°C in a gyratory shaking water bath at 250 rpm. Phage lysates were centrifuged
(5,000 ? g for 15 min) to remove cellular debris, filter sterilized (pore size, 0.22
?m; Millipore), and stored over a drop of chloroform at 4°C in amber bottles.
The phage preparations to be used therapeutically were passed through a column
containing Detoxi-endotoxin removing gel (Pierce, Rockford, IL), as recom-
mended by the manufacturer, and eluted with pyrogen-free water. The eluted
phages were diluted to the appropriate titer with filter-sterilized phosphate-
buffered saline (PBS; pH 7.2) prior to administration to the mice. Phage titers
were determined by serial dilution and plaque assays by the soft overlay tech-
nique (1). This entailed the addition of 100 ?l of the different phage dilutions to
100 ?l of an overnight culture of their host strain. The mixture was then allowed
to stand at room temperature for 5 min for phage adsorption, after which 3 ml
of soft agar (0.7% LB agar maintained at 48°C) was added and the mixture was
poured over an LB agar plate. The soft agar overlay was allowed to solidify, the
plates were incubated overnight at 37°C, and the plaques were counted to
determine the phage titer.
Selection of therapeutic phages. To select for the phages to be used in our
phage cocktail, we used two criteria: virulence and host range (i.e., utilization of
different phage receptors). Of our 13 ATCC phages, 7 were able to grow on
PAO1Rif. Of those, two formed hazy plaques, suggesting that they may be
lysogenic. To determine the relative virulence of the remaining five phages, we
developed an in vitro virulence test in which we determined the MIC required to
* Corresponding author. Mailing address: Department of Microbi-
ology and Immunology, Texas Tech University Health Sciences Cen-
ter, 3601 4th Street, Lubbock, TX 79430. Phone: (806) 743-2555. Fax:
(806) 743-2334. E-mail: email@example.com.
† Present address: Biological Sciences Department, Auburn Univer-
sity, Auburn AL 36849.
‡ Present address: Kilimanjaro Christian Medical College, Tumaini
University, P.O. Box 2240, Moshi, Tanzania, Africa.
?Published ahead of print on 26 March 2007.
Page 2
clear (lyse) an exponentially growing culture of PAO1Rif(?107/ml) over a given
period of time (5 h). Those with the lowest MICs were considered the most
virulent. We realize, however, that we are measuring only one virulence param-
eter and that in vivo and in vitro virulence may not be equivalent and may be
determined by other phenotypic traits (6, 21).
Resistance to phage often arises through bacterial mutations that alter recep-
tors on the bacterial surface to which the phage binds (phage receptors). In an
attempt to decrease the likelihood of the emergence of phage-resistant PAO1Rif
strains, we selected phages that utilized different phage receptors for infection.
To identify such phages we isolated PAO1Rifmutants resistant to each of the five
different phages being analyzed and determined the sensitivities of these mutants
to the other phages being analyzed. We assumed that a phage to which a
PAO1Rifphage-resistant mutant was sensitive did not share a common receptor
with the phage to which the mutant was resistant.
Based on our virulence and host range (receptor usage) tests, we selected
three phages for use in this study. The phage cocktails used in this study con-
tained approximately 108PFU/100 ?l inoculum of each of the following phages:
Pa1 (ATCC 12175-B1); Pa2 (ATCC 14203-B1), and Pa11 (ATCC 14205-B1)
(ATCC catalogue of bacteria and bacteriophages, 18th ed., 1992).
Animals. Adult female ND4 Swiss Webster mice (weight, 20 to 24 g) were used
for this study. The animals were anesthetized with 0.4 ml of 5% sodium pento-
barbital by intraperitoneal (i.p.) injection. The mice were housed in the Texas
Tech University Health Sciences Center Vivarium. The animals were treated in
accordance with protocol no. 96020-06, approved by the Animal Care and Use
Committee at Texas Tech University Health Sciences Center in Lubbock.
Thermal injury model. The mouse model of thermal injury of Stieritz and
Holder (28), as modified by Hamood (11), was used in this study. Briefly, the hair
was clipped from the backs of anesthetized mice, and the area was denuded with
a commercially available hair remover. The mice were securely placed into a
template with an opening of 4.5 cm by 1.8 cm to expose their shaved backs. A
nonlethal full-thickness thermal injury to the skin was induced by placing the
exposed back area to 90°C water for 10 s. Fluid replacement therapy consisting
of a subcutaneous (s.c.) injection of 0.8 ml of a 9% NaCl solution was adminis-
tered immediately following the burn. The mice were challenged by s.c. injection
of 100 ?l of the PAO1Rifinoculum (2 ? 102to 3 ? 102CFU) directly under the
anterior end of the burn. The phage cocktail was administered immediately after
the P. aeruginosa challenge.
During recovery from anesthesia, the mice were kept under warming lights and
observation. The cumulative mortality among the treatment groups was recorded
at 48 and 72 h postinfection (hpi). Lethargic animals were monitored every hour.
The surviving animals were killed at 96 hpi. Liver and spleen tissue samples were
removed from the animals, weighed, suspended in 2 ml of filter-sterilized PBS
(pH 7.2), and homogenized with sterile mortars and motor-driven Teflon pestles.
The numbers of PAO1Rifcells (CFU/g tissue) were determined by serial dilution
and plating on LB agar containing 80 mg/ml of rifampin. The titers (PFU/g
tissue) of the phages recovered from the tissues of mice were determined by the
soft agar overlay technique described above, following the addition of a few
drops of chloroform (per ml).
Pharmacokinetic studies. A phage cocktail inoculum (?3 ? 108/100 ?l per
inoculum) was administered to unwounded, noninfected mice i.p., intramuscu-
larly (i.m.). or s.c. Three animals from each treatment group were killed at 0.5,
12, 24, 36, and 48 h following phage injection. Briefly, blood, obtained by cardiac
puncture from anesthetized animals, was collected in tubes containing EDTA.
After blood collection, the anesthetized mice were euthanized by injection of
Fatal Plus (sodium pentobarbital), followed by cervical dislocation. Liver and
spleen tissue samples were removed from the animals. The tissues were weighed,
suspended in 2 ml of filter-sterilized PBS, and homogenized with sterile mortars
and motor-driven Teflon pestles. The phages in the tissues were enumerated as
described above and are expressed as PFU/gram of tissue.
Statistical analysis. Fisher's exact test (Statview for Windows; SAS Institute,
Cary, NC) was used to determine the significance of the differences in survival
among the treatment groups and the differences in the distributions of the
phages to the tissues.
Protection studies. The ability of the P. aeruginosa-specific
phages to prevent P. aeruginosa infections was examined by use
of a modified mouse model of thermal injury, as described
above. A phage cocktail containing 1 ? 108PFU of each of
three different phages (3.0 ? 108PFU total) was administered
i.p., i.m., or s.c. to infected and uninfected wounded animals.
As a control for the virulence of the PAO1Rifinoculum, an-
other group of mice was injected with the bacterial inoculum
only (no phage). To examine the toxicity of the phages in
compromised animals, the wounded but noninfected groups
were injected with the phage cocktail (but not P. aeruginosa).
Animal deaths were recorded at 48 and 72 hpi.
The results of these experiments are presented in Table 1.
All of the thermally injured mice that were not infected with
PAO1Rifbut administered the phage cocktail survived, indi-
cating that the phage cocktail was not toxic to traumatized
mice. In the absence of phage there was a 94% rate of mor-
tality in the wounded infected mice in the first 72 hpi. When
the phages were administered i.m. or s.c., the rates of mortality
were reduced to 72% and 78%, respectively; and by sharp
contrast the rate of mortality was reduced to 12% when the
phages were delivered i.p. These results demonstrate that the
parenterally administered phages significantly increased sur-
vival in infected and wounded mice and that the relative pro-
TABLE 1. Protection studies: efficacy of phage therapy on P. aeruginosa infection of burn wounds
No. of survivors/total no. of mice (% survival)a
Expt 1Expt 2Expt 3 Combined exptb
48 hpi72 hpi 48 hpi 72 hpi48 hpi 72 hpi48 hpi 72 hpi
PAO1 only
Phage by i.p. route only
Phage by i.m. route only
Phage by s.c. route only
Phage by i.p. route ? PAO1 infection
Phage by i.m. route ? PAO1 infection
Phage by s.c. route ? PAO1 infection
0/6 (0)
6/6 (100)
6/6 (100)
6/6 (100)
6/6 (100)
3/6 (50)
2/6 (33.3)
0/6 (0)
6/6 (100)
6/6 (100)
6/6 (100)
5/6 (83.3)
2/6 (33.3)
2/6 (33.3)
1/6 (16.7)
6/6 (100)
6/6 (100)
6/6 (100)
6/6 (100)
3/6 (50)
3/6 (50)
0/6 (0)
6/6 (100)
6/6 (100)
6/6 (100)
6/6 (100)
0/6 (0)
0/6 (0)
2/6 (33.3)
6/6 (100)
6/6 (100)
6/6 (100)
5/5 (100)
4/6 (66.7)
5/6 (83.3)
1/6 (16.7)
6/6 (100)
6/6 (100)
6/6 (100)
4/5 (80)
3/6 (50)
2/6 (33.3)
3/18 (17)
18/18 (100)
18/18 (100)
18/18 (100)
17/17 (100)c
10/18 (56)d
10/18 (56)d
1/18 (6)
18/18 (100)
18/18 (100)
18/18 (100)
15/17 (88)e
5/18 (28)
4/18 (22)
aThe cumulative survival was determined at 48 h and 72 hpi.
bThe average percent survival of animals in three experiments determined at 48 and 72 hpi.
cThe rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P ? 0.0001) than that for untreated infected control animals at the same
time period.
dThe rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P ? 0.01) than that for untreated infected control animals at the same
time period.
eThe rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P ? 0.0026) than that for untreated infected control animals at the same
time period.
Page 3
Page 4
tection afforded by the different routes of phage administration
was i.p. ? i.m. or s.c.
Of the wounded and infected animals receiving the phages
i.p., only 2 of the 17 animals had died by 72 hpi (at 53 hpi and
64 hpi, respectively). The surviving animals were killed at 96
hpi, and the numbers of PAO1Riforganisms detected from the
tissues of surviving animals was compared to the numbers from
the tissues of animals that died from the P. aeruginosa infec-
tion. The mean bacterial counts in the tissues of animals that
died were 1.53 ? 109CFU/g liver and 6.68 ? 107CFU/g
spleen. The mean bacterial counts in the tissues following
successful i.p. phage therapy were 5.26 ? 102CFU/gram liver
and 2.93 ? 102CFU/gram spleen. These results suggest that
the cause of death was the result of systemic P. aeruginosa
infection and that, as one might expect, successful phage ther-
apy correlates with a reduction in the PAO1Rifburden.
To determine if phage-resistant derivatives of PAO1Rif
emerged from the infected mice, we analyzed the PAO1Rif
isolates from the tissues of those mice that had died by 48 hpi
for their phage sensitivities. All isolates tested (?100) were
sensitive to each of the phages in the cocktail (data not shown).
Hence, the death of these animals was not the result of the
emergence of a phage-resistant derivative of the PAO1Rif
strain. The numbers of phages in the liver and spleen of ani-
mals that succumbed to P. aeruginosa infection in the first 48
hpi were also enumerated to determine if the phages had
multiplied. Considering the average weight of these organs (4.6
g and 2.27 g of liver and spleen, respectively) and assuming
100% phage recovery, each mouse harbored a minimum of
7.5 ? 109to 10 ? 109phages. This represents an increase of
approximately 20-fold over that administered to these mice
(?3 ? 108/mouse), indicating that the phages multiplied in
vivo, although obviously not to levels that were enough to save
the animal.
Pharmacokinetic studies. In an attempt to determine why
delivery of the phages by the i.p. route was more efficacious
than delivery of the phages by the i.m. or the s.c. route for the
treatment of infected animals, we examined the pharmacoki-
netics of the phages introduced by the i.m., s.c., or i.p. route in
uninjured, uninfected animals. Three animals each from
groups receiving the phage cocktails i.p., i.m., or s.c. were killed
at 0.5, 12, 24, 36, and 48 hpi. The numbers of phages detected
per gram of liver and spleen and per milliliter of blood are
shown in Fig. 1. In each tissue examined, a consistent pattern
of the relative PFU levels after the administration of the
phages by the different routes was observed: i.p. ? i.m. ? s.c.
In the mouse model of thermal injury, 2 ? 102to 3 ? 102
PAO1Rifinjected at the burn site resulted in 83 to 100%
mortality by 48 hpi. Rumbaugh et al. have shown that the P.
aeruginosa organisms in such an infection proliferate and
spread systemically from skin to underlying tissues and that
within 24 hpi as many as 104PAO1RifCFU per gram of tissue
was detected in the liver and spleen (21). In this study we have
demonstrated that a single dose of a phage cocktail can effec-
tively decrease the rate of mortality due to P. aeruginosa in-
fection of burn wounds in the mouse model of thermal injury.
This protection was shown to be the result of a significant
decrease in the numbers of P. aeruginosa organisms found in
the successfully treated animals, indicating that the bacterial
viruses used were able to locate and kill PAO1Rifbefore the
animal succumbed to bacteremia and septic shock. However, it
was also found that not all infected animals which were treated
with the phages survived and that the route of phage admin-
istration was particularly important to the efficacy of the
treatment, with the i.p. route providing the most significant
protection (87%) of the routes tested (Table 1).
It was also found that the P. aeruginosa phages had multi-
plied in mice that had died of infection and that phage-resis-
tant P. aeruginosa strains were not recovered from these ani-
mals. These results suggest that the use of a phage cocktail
containing phages that use different receptors may have pre-
vented the emergence of phage-resistant mutants and that the
therapeutic phages had found their host (PAO1Rif) and mul-
tiplied, but apparently not in sufficient time and/or in sufficient
numbers to prevent mortality. Hence, the differences in the
efficacies of the different routes of phage administration may
be due to the rate and dose of phage delivery to their targets.
This explanation is somewhat supported by the observation
that the P. aeruginosa phages administered by the i.p. route
were delivered at a higher dose, were delivered earlier, and
were delivered for a more sustained period of time to the
examined tissues of a mouse (Fig. 1) than the phages delivered
by the s.c. or i.m. route.
It should finally be pointed out that the mouse model of
thermal injury is a very stringent test of phage therapy for a
systemic infection. Highly virulent PAO1Rifcells injected s.c.
beneath the burn wound, allowing the organisms to proliferate
very quickly and spread systemically to cause septic shock and
death in a relatively short period of time (24 to 48 h). By
comparison, the rates of proliferation and systemic dissemina-
tion from natural infections acquired at burn wound surfaces
are usually much slower. Furthermore, in most human burn
wounds, infection occurs after admission to a hospital or burn
ward and is often caused by a hospital-associated strain. The-
oretically, such infections could be more conducive to phage
therapy/prophylactics than would P. aeruginosa infections in
the animal model tested here because of the chronic nature of
the infection. On the other hand, some chronic wounds are
populated by biofilms, which may be more difficult to treat with
phage and/or may require different types of therapeutic phage
than that used for the treatment of systemic infections.
Chronic infection may require prolonged treatment with
phage, which may in turn select for phage resistance and in-
FIG. 1. Pharmacokinetics of the phages in noninfected mice. A cocktail containing ?3 ? 108phage was injected i.p., i.m., or s.c. into uninjured,
uninfected mice. Groups of mice (n ? 3) were killed at 0.5 h hpi, 12 hpi, 24 hpi, 36 hpi, or 48 hpi. Tissues were removed and the numbers of PFU
were determined by serial dilution and plating on PAO1Rif. (A) PFU/gram liver; (B) PFU/gram spleen; (C) PFU/ml blood. Values are means ?
standard errors of the means.
Page 5
duce an immune response, which could reduce the therapeutic
value of phage treatment, although phages, unlike antibiotics,
evolve with their host(s). Obviously, more detailed studies ex-
amining the effect of the phage dosage, the routes and timing of
phage administration, the pharmacokinetics and tissue tropism of
the phages used, as well as determination of the phenotypic traits
of the most effective therapeutic phages for particular types of
infections will be needed to determine if phage therapy will pro-
vide a much needed alternative/supplement for the treatment
of bacterial infections. However, with that said, recent, well-
controlled animal studies, which have successfully applied phage
therapy to multiple types of bacterial infections, have spawned
new enthusiasm for an old idea (3–7, 10, 14, 19, 23–26, 33–35),
and the FDA has recently approved phase I trials for the use of
phage to treat bacterial infections of diabetic foot ulcers (R.
Wolcott personal communication and http://sanjose.bizjournals
We thank Abdul Hamood and Kendra Rumbaugh for their moral
and technical support, John Griswold for providing space and equip-
ment to accomplish thermal injuries, and Ben Burrows and Probhjit
Chadha-Mohanty for critical reading of the manuscript.
This work was supported in part by a Texas Tech University School
of Medicine seed grant (to J.A.F.) and grants from the Texas Tech
University Biology Department (to M.V.) and the Texas Tech Univer-
sity Graduate School (to M.V.).
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Tackling Those Bumps & Bruises: More athletic trainers on way
Monday, October 12, 2015
The Carolina Panthers and the National Football League Foundation will pump $25,000 into putting more athletic trainers in local high schools, Sentara Healthcare has announced.
- EC police probe man's shooting
Tuesday, October 13, 2015
Elizabeth City police are investigating following the shooting of a motorist on Southern Avenue earlier this morning. Capt.
- No court date yet for water dispute
Monday, October 12, 2015
Pasquotank County and Elizabeth City officials still don't have a court date set for resolution of their legal dispute over water rates, but county officials said Monday the sooner a date is set the better.
- COA board considers changes to programs
Monday, October 12, 2015
College of The Albemarle's Board of Trustees is expected to approve a program change today that will switch surgical technology from a diploma program to one awarding an associate's degree.
- Walk for Hunger: Hundreds walk for Food Bank — w/video
Sunday, October 11, 2015
Dr. Carol Anderson on a cool and overcast Sunday afternoon was about to become a first-time participant in the 32nd annual Walk for Hunger.
- ECSU workforce down 12 percent in year
Monday, October 12, 2015
Elizabeth City State University's full-time workforce has shrunk about 12 percent since Chancellor Stacey Franklin Jones arrived on the campus a year ago — a development the university says makes its faculty-to-student ratio compare favorably to other colleges and universities its size.


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Who spiked the punch? Vodka or rum, mixed drinks or shots, get recipe ideas for your next party.
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Got the periodic table memorized? Learn all about chemistry, atoms, organic compounds and more.
Whether you like romantic comedies or black comedies, have a laugh by Stumbling through funny films.
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Adina Howard
in Music
From the depths of the R&B music revolution emerges an artist whose multi-dimensional lyrical decadence is nothing short of sensational. She is the innovative, yet sensual phenom whose passion and drive for success propelled her music into a new dimension of personal growth for music lovers to experience. Her name is Adina Howard.
In 1995, Howard hit the charts with her platinum selling hit single "Freak Like Me", that was featured in her debut album, Do You Wanna Ride?. Following her debut, Howard introduced a second album, Welcome to Fantasy Island, with
her lead single, "(Freak) And U Know It". In 1997, she also collaborated with Jamie Foxx on the Platinum selling slow jam, "T-Shirt & Panties" which appeared on the soundtrack to the 1998 feature film Woo.
By 2004-2007, Howard released two more albums, "The Second Coming" on Rufftown Records, featuring the single "Nasty Grind" and "Private Show" released by Arsenal Records along with a promotional single "Picture This." The album managed to reach #17 on the iTunes R&B music chart. (http://adinahoward.com)
Al Diaz, Angela Gower Johnson, Brian Howard What About Minerals?
in Lifestyle
Al Diaz, Angela Gower Johnson, Brian Howard share their insights on What About Minerals?
Wednesday, October 6th 10am PST
Host Al Diaz: An acclaimed and internationally recognized Visionary, Transformational Guide, and Change Agent as an International Keynote Speaker, Author, Film Producer, and online Radio Host.
Co-host Angela Gower Johnson provides coaching and consulting services to entrepreneurs, coaches and artists who are eager to embark on their own quest for their ultimate dream.
Special guest Brian Howard from the Isle of Wight in the UK.
Brian has recently retired as an Osteopath after 20yrs practise in the UK, during this time he has completed post graduate training in Cranial Sacral Therapy, Herbal Medicine and Neuro-Developmental Programmes incorporating Sound Therapy and gentle enhancement with groups such as Samonas, H.A.N.D.L.E. I.N.P.P. working mainly with children who have special needs.
mineralsforbetterhealth.com or mineralstosupportyou.com
Awardwinning author/journalist Howard Bryant talks LEGENDS on #ConversationsLIVE
in Football
Host Cyrus Webb welcomes award-winning author/journalist and media personality Howard Bryant to #ConversationsLIVE to discsuss his love of sports and how he has been able to tie that in with the history of the Super Ball in his new book LEGENDS: Football.
For Success, It's Not How Smart You Are In Business, It's How Aware You Are
in Business
Today's 5 minute Talk Business With Howard podcast with business expert and CEO advisor, Howard Lewinter, to improve and grow your business is: For Success, It's Not How Smart You Are In Business, It's How Aware You Are.
It Isn't How Smart You Are In Business, It's How Aware You Are
in Business
Today's 5 minute Talk Business With Howard podcast with business expert and CEO advisor, Howard Lewinter, to improve and grow your business is: It Isn't How Smart You Are In Business, It's How Aware You Are.
Afronerd's Grindhouse Welcomes Dr. Sheena Howard; Pulp/Pop Talk This Sat @6pmEST
Greetings to our ever faithful listenership! Welcome to the latest edition of The Grindhouse Mashup, courtesy of the Afronerd Radio machine. Join your Podcast Doom Patrol-Daryll B., Capt. Kirk and Dburt this Saturday at 6pm EST as they wax about the following issues: the crew welcomes educator, Dr. Sheena Howard to the show as she discusses her latest book, Black Comics: Politics of Race and Representation. The crew will pick her brain to assess her impression of the comic book industry's recent high profile diversity initiatives and the uptick of ethnic characters; our impressions of a recent Bleeding Cool article's query as to why many Black comic fans appear to avoid African-American comic creators at the convention circuit; HBO and Zack Snyder (Batman vs Superman) appear to be in talks to develop a Watchmen TV series; and not to be outdone, ABC may be optioning the late Dwayne McDuffie's Damage Control for a comedy TV seres; is the need for gun control/scrutiny becoming more evident with the recent college shooting tragedy in Oregon?; actor, Jessie L. Williams discusses "bi-racial privileges" in the context of race relations in the wake of the Black Lives Matter movement; Pulitzer Prize winning author Junot Diaz (The Brief Wondrous Life of Oscar Wao) unpacks diversity issues on Late Night with Seth Myers (he also makes his MIT creative writing students watch Star Wars). And lastly, The Mission's Joseph Illidge laments about the lack of Black women depicted in a 15min Yahoo highlight reel entitled, Rise of the Female Superhero (infrastructure!). Call the hosts live at 646-915-9620.
Soul Paradise with Rolls Royce Howard
in Music
Soul Paradise with Rolls Royce Howard....Playing them Solid Gold Oldies
What To Do In A High Pressure Business Situation
in Business
Today's 5 minute Talk Business With Howard podcast with business expert and CEO advisor, Howard Lewinter, to improve and grow your business is: What To Do In A High Pressure Business Situation.
Stew and The Nunn, Episode 9: Howard Love and Paul Lietner-Wise
in Military
We will be talking with Mr. Howard Love. Howard served in the US Navy 1965-1969, to include service in the Vietnam War on the USS Enterprise. He worked on flight decks of 3 different carriers. Howard is now giving back and trying to serve those who are serving by sending care packages to the troops for 10 years now.
Paul Lietner-Wise known for his amazing fire arm designs. His piston designs are truly the benchmark in the firearm industries. He's a dynamic personality and his marketing approaches are catching the eye of more than just the firearm industry.
Author - Dorsey Howard on "The bully"
in Business
Business of Wednesday Best Resources - Apostle SB Barber talks w/author Dorsey Howard, Jr 'ONE WAY, NO LEFT TURN' (MN).
#SBBMS definition of Best Resources are identifiable spiritual & natural suppliers of Resources to elevate & benefit an individual, a community, a nation.
Apostle SB Barber & husband Prophet Charles Stalling lead out GRACE & TRUTH Ministries GTM5 - The Church. "We welcome you to gather with us in our GTM5, 5Fold virtual sanctuary Conference Call for prophetic release & teaching the Word of the Lord. Visit: https://www.startmeeting.com/wall/graceandtruthministries .
For show Booking/Inquiries contact: firstname.lastname@example.com.
Follow us on Twitter@GMNetwork, Facebook@GMNLiveTv, YouTube@GMNLiveTv, Instagram@GMNLIVETV and Instagram@SbNMepk; BlogTalkRadio.com; GMNLive.com; Get us on iTunes@SBBarberMorningShow.
Dr. Imani Interviews Nevada Howard Tonight 8pm EST
in Health
If you have questions about Community Crowd Funding, Nevada Howard is he person to ask. Dr. Imani will be asking the questions tonight so that we will all be clear. Community Crowd Funding is not a "Pyramid", not a loan or grant and you never have to repay it! You can also call in if she misses any important ones that you wish to ask!
Nevada Howard has 25+ years in Financial Services, Public Speaking and Coaching in the areas of Financial, Personal and Business Development.
She has coached well over 1,000 students and has built multiple large mlm/network marketing teams. She has done speaking engagements for well known companies in both the public and private sector.
Nevada Howard is a successful Entrepreneur, Financial Consultant, Motivational Speaker/Teacher, Success Coach and Internet Marketer. She has a passion and talent for speaking, teaching and empowering others to "Tap Into Their Greatness" in their personal, business or financial life.
As a way of giving back to the community and being passionate and dedicated to your success, Nevada offers affordable one- on-one and group coaching and both online and offline workshops.
Nevada is also the Founder of Nevada University Online "The No More Broke Business School and the Founder and CEO of Citizens First Financial Group,
Nevada is a 1983 graduate of the University of Maryland with a Bachelors degree in Pshycology, a graduate of both George Washington University's and Dale Carnegie's Business Management Programs. She is also a graduate of Dale Carneige's Public Speaking Program and is a member of Delta Sigma Theta Incorporated.
CEOs And Business Owners Need To Anticipate
in Business
Today's 5 minute Talk Business With Howard podcast with business expert and CEO advisor, Howard Lewinter, to improve and grow your business is: CEOs And Business Owners Need To Anticipate.
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"Addicted to Fresno" is Your Next Favorite Movie from Jamie Babbit and Natasha Lyonne
"A murder, Fred Armisen, a bar mitzvah and Molly Shannon."
"A murder, Fred Armisen, a bar mitzvah and Molly Shannon."
Yup, we found 100 films for lesbian, bisexual and queer women that are good enough for one of our most epic lists of all time.
The Same Difference takes the lid off of the many boxes that we as a community put ourselves into in respect to gender.
"Yep, that's right. Out of 314 major Hollywood film releases, one single film — Melissa McCarthy's Tammy — passed the Vito Russo test with queer female characters."
Breakout writer/director/actor triple threat, Desiree Akhavan, brings us a three dimensional bisexual Persian lead character and also Robin is at a kink cafe and we all wish we were there, too.
"This is a Valentine for people whose stories haven't yet been told."
Tina Belcher, Hero Cat, a t-shirt you'll probably like, rape culture at its finest, Ava DuVernay's snub, indigenous women of Canada, Janet Mock interview, CeCe McDonald interview, is self-care ruining your relationships?, a super fucking logical thing re: kids and nutrition, Stevie Nicks, your hat, and so much more!
"The Republicans are funding terrible gay movies to make the entire population straight!"
I know you probably read the longline (Two codependent best friends — one straight girl, one lesbian — and the man who comes between them.) and wanted to shoot yourself, but this movie isn't about a man at all AND it's pretty good.
Lesbian movies are notoriously terrible, but these are some real diamonds in the rough. It's getting colder and darker so there's no day like today to curl up with a girl-meets-girl-and-shit-gets-complicated film!
I am in an extended food coma from 10 days of eating nothing but fast food and concession stand snacks. Send help. But first, check out these lesbian romcoms, queer comedies and dramas.
In the Turn is a documentary about a 10-year-old transgender girl who finds acceptance and empowerment in the company of queer roller derby collective, The Vagine Regime.
The lines between friendship and romance blur in this indie comedy that's about to take film festivals by storm.
"Start-up culture is odd. There's a lot that I struggle with — it's not something particularly designed for anyone who isn't already privileged. It's hard to go into it without a safety net. There's a certain element of romanticizing struggle that is hard to internalize as a woman, a queer woman, and/or a woman of color. "
A university student feels pressure to be perfect but finds refuge in the Australian fetish scene.
The film festival was not as gay as hoped, and it turns out I'm still not cynical enough to not cry when ladyqueers say "I do."
HEY this is an open thread! What are you doing tonight? What are you drinking? What are you watching? Get in here!
Sundance was SUPER FUCKING GAY THIS YEAR, YOU GUYS. Let's talk about the best queer films.
Talking Pictures is a movie interruption that capitalizes on how awful/awesome queer movies can be. Featuring Hannah Hart, DeAnne Smith, Brittani Nichols and Carly Usdin.


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Remember me
The United States is dropping a $500 million Pentagon program to train Syrian rebels fighting the administration of President Bashar al-Assad, the New York Times reported
Turkey will send troops to Armenia on Oct. 11 in compliance with an international treaty, the Turkish General Staff has stated
Turkey is concerned about the potential for a fresh wave of Syrian migrants arriving at its border as a result of Russian air strikes in Syria, foreign ministry spokesman Tanju Bilgiç said.
Transfer of four separate defense system equipment Turkey demands from the United States is still pending, amid different approaches between the two NATO allies towards regional issues, particularly Syria
Turkey's European Union accession process will "advance rapidly" if main opposition Republican People's Party (CHP) will come to the government after the Nov. 1 snap election, CHP leader Kemal Kılıçdaroğlu said in an interview Oct. 9.
State Department Spokesperson John Kirby has called on Turkey to respect media freedoms and due process
Peoples' Democratic Party (HDP) co-chair Selahattin Demirtaş made a visit to the building of daily Hürriyet on Oct. 8 to express his support to the daily in the wake of recent attacks on the daily and one of its leading journalists.
The consul generals of four EU countries have visited Hürriyet journalist Ahmet Hakan in his Nişantaşı apartment, where he is recovering from injuries after being subjected to a violent attack last week.
The European Union is seeking to accelerate Turkey's almost stalled accession negotiation process by annexing a set of priorities and concrete recommendations to its soon-to-be released progress report, seen as a short-term road map for the next government to be formed after Nov. 1 elections.
NATO has said it was prepared to send troops to Turkey to defend its ally after violations of Turkish airspace by Russian jets bombing Syria and Britain scolded Moscow for escalating a civil war that has already killed 250,000 people
A Turkish court has sentenced a man, who initially faced a total of 150 years in prison for drugging and sexually abusing two 14-year-old girls and one 15-year-old girl after faking his ID, to 10 years in jail due to his "respectable attitude" at the hearings.
Fresh water has reached northern Cyprus through a pipeline project from Turkey as part of a "peace project" to provide the arid island with a source of water, Turkish Forestry and Water Affairs Minister Veysel Eroğlu has said
ISTANBUL - Doğan News Agency
The U.S. dollar opened the day under 2.9 Turkish Liras on Oct. 9 and declined to around 2.89 liras, the lowest level in the last 1.5 months, as the U.S. Federal Reserve (Fed) gave signals that it would wait further before raising interest rates
Şebnem Turhan - ISTANBUL
Global Finance magazine has lowered the rank of Turkish Central Bank Governor Erdem Başçı from B+ to C, ranking him as one of the worst performers this year.
MOSCOW - Reuters
Russia's Gazprom has declined to provide Turkey with an additional 3 billion cubic metres of gas via the existing Blue Stream pipeline, chief executive Alexei Miller said on Oct. 8
ISTANBUL – Doğan News Agency
Security forces seized a total of 4.5 kilograms of explosive material placed inside a pressure cooker under a suspension bridge in Istanbul on Oct. 8
TEHRAN - Agence France-Presse
Iran on Oct. 9 declined to confirm a claim by a US official that Russian missiles targeting rebels in Syria crashed in its territory this week.
ALEPPO, Syria – Anadolu Agency
Anadolu Agency photojournalist Saleh Mahmoud Laila was killed in a suicide car bomb attack in Syria on Oct. 8.
ANKARA - Reuters
An Iranian Revolutionary Guards general has been killed near Aleppo, where he was advising the Syrian army on their battle against Islamic State of Iraq and the Levant (ISIL) fighters, the guards said in a statement on Oct. 9
JERUSALEM - The Associated Press
Jerusalem's mayor, caught on video this week with a gun slung over his shoulder while visiting a Palestinian neighborhood, is making no apologies for the display of force. He says he's helping keep his city safe.
PARIS - Agence France-Presse
French warplanes carried out a second wave of strikes overnight on Islamic State of Iraq and the Levant (ISIL) targets in Syria, Defence Minister Jean-Yves Le Drian said Oct. 9.
BEIRUT - Agence France-Presse
Four Russian cruise missiles aimed at targets in Syria crashed in Iran, a US official said Oct. 8, as regime troops backed by Lebanon's Hezbollah pressed a "vast offensive" against rebels in the war-torn country's west
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OPINION - all the columnists »
"Have a friend like a Russian, have an enemy like a Russian."
Neither Turkey nor its NATO allies got the Russian message, conveyed through Syria, when a Turkish military reconnaissance aircraft was shot down, apparently in Syrian airspace over the Mediterranean in June 2012.
Daron Acemoğlu, Turkey's best shot at the Nobel Economics Prize, and Murat Üçer, who knows the Turkish economy better than anyone else, published the paper, "The ups and downs of Turkish growth, 2002-2015: Political Dynamics, the European Union and the Institutional Slide," on Oct. 5.
If, in this country, we could convert the energy we spend on absurd discussions to, for instance, electricity, most probably we would not have the need for Russia to build a nuclear power plant for us.
Justice and Development Party (AK Party) Central Committee member (who is also running for Diyarbakır's deputy position) Galip Ensarioğlu revealed a true, psychopathic incident.
The Russian desire to reach the "warm waters" of the Mediterranean goes back to before the First World War
The reputation of journalists has been growing in the negative direction for quite a long time.
A Turkish-born scientist made the headlines yesterday for winning the Nobel Prize in Chemistry, while also raising the question whether it would be possible had he stayed in Turkey instead of moving to the United States
Tunisia's National Dialogue Quartet won the Nobel Peace Prize on Oct. 9 for its contribution to building democracy after the Jasmine Revolution in 2011, the Nobel Committee said.
Erospolis takes a break from lively social life and reflects on the international and local corporate world with its acronyms, euphemisms and cultural traps.
Pluto has blue skies and patches of frozen water, according to the latest data out Oct. 8 from NASA's unmanned New Horizons probe, which made a historic flyby of the dwarf planet in July.
Kayseri's Kültepe mound was the trade hub of the Middle East. New excavations hope to provide more information on this ancient hub
Istanbul's BLOK art space is hosting a new exhibition by South African artist Nicky Broekhuysen, "The Stonebreakers."
Istanbul Bilgi University will today host Kevin (Kal) Kallaugher, the political cartoonist of The Economist and the daily newspaper The Baltimore Sun.
Following the gathering of cinema lovers in different countries, a Kiev-based young team's short film food festival project, "Food Film Festival World," will take place at the TÜRVAK Cinema Museum.
Belarusian writer Svetlana Alexievich won the Nobel Prize in literature Oct. 8 for works that the prize judges called "a monument to suffering and courage."
The 35th International Istanbul Boat Show, Turkey's first where vessels are being displayed on water, will run until Oct. 11 and showcase 200 boats worth a total of 250 million euros.
Turkey is continuing talks with NATO and its bilateral partners to enhance its defense capabilities, Foreign Ministry Spokesperson Tanju Bilgiç said Oct. 9, noting the discussions include Patriot missiles
Turkey launches Bayraktar amphibious ship
Baby caretta carettas start their journey from southern Turkey
Istanbul Boat Show opens with 200 boats worth a total of 250 million euros
Halfeti - A town of mesmerizing beauty
Exhibition shows Istanbul through eyes of children
Secret weapons of Turkish army: locally produced rocket launchers, missile systems
The bugs of Ankara: The weirdest scenes that anyone can run into in Turkish capital
A bird's eye view tour of Turkey's eastern provinces of Van and Hakkari
Turkish man with four wives has his 32nd child
Meet the Turkish Superhumans
Pope Francis prays in Istanbul's Blue Mosque
Drought in Lake Van exposes long-submerged Ottoman structures
Perseid meteor shower in Turkey
In photos: Bird attempts to perch on Erdoğan's head
Top 21 transfers ahead of new football season in Turkey
30 best Turkish movies of all time
Best souvenirs to buy from 30 places in Turkey
Two Turkish women photograph butterflies as retirement hobby
25 hilarious reactions to the Irish-Kuwaiti tourist beating Turkish shopkeepers
13 of Turkey's historic heritage sites destroyed by erroneous 'restoration'
Turkey solemnly celebrates Victory Day amid clashes with outlawed PKK
Istanbul lives on in memories with 12 photos
19 hyper-realist paintings of Turkish artist Taner Ceylan
Ten secret escapes across Anatolia: Turkey's Slow City movement
19 drawings inspired by drowned Syrian toddler en route to Europe
Top 50 trekking routes in Turkey
Top 10 Fish Restaurants in Turkey
Istanbul's design route for September 2015
Top 10 most beautiful gardens in Turkey
The little faces of the Syrian refugee crisis in Turkey
14 places in Turkey to go to in autumn
'Chic women' across Turkey's western coast cycle for sustainable transportation
10 best activities in Turkey to do for less than $30
Bird's-eye pictures reveal risk of devastation for Istanbul's city walls
In photos: Super blood moon
Top 10 restaurants for romance in Turkey
Outcry in Turkey over 20-year-old girl's brutal killing
Turkey raises flag on new location for Süleyman Şah tomb in Syria
Two dead in Turkish fighter jet crash in Central Anatolia
First prayer in 46 years at historic synagogue in Turkey's northwest
Southeastern Turkey eyes return to glory days as cultural hub after peace bid
Massive power blackouts hit Turkish cities
Driver injured as Fenerbahçe team bus comes under fire in Trabzon
Turkish President Erdoğan pays official visit to Iran amid tension
Erdoğan's new residence photographed for the first time
Kim Kardashian comes to Armenia
Exhibit showcases world of children during Holocaust
Excavation begins to find possible Dersim massacre victims in Tunceli
Supermodel Gisele Bundchen makes teary last catwalk turn
R2-D2 plane to spirit Star Wars fans far, far away
World's largest 'tulip carpet' in Istanbul
People participate in the "Colour Run 2015" in Paris
Dancers perform for peace in Times Square before 1915 anniversary
Children draw Turkey they see
Spirit of Gallipoli revisited at Atatürk's Mausoleum
Riots erupt in Baltimore
Nepal quake aftermath
Police use force to disperse May Day demonstators in Istanbul
Antalya Sand Sculpture Festival to bring the Seven Wonders to life
Celebrities hit the red carpet at the China-themed Met Gala
World's weapons on display at IDEF 2015
Turkey celebrates Hıdırellez, the arrival of Summer
Lightning illuminates Istanbul sky
Turkey's worst mining disaster remembered on first anniversary
56th International Art Exhibition starts in Venice - "La Biennale di Venezia"
Beauty queens from seven continents meet in Turkey
"Children becoming Buddhist monks" in South Korea, ahead of Buddha's birthday
Merkel sings with Turkish children at German school
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Select Local Merchants
Bassett'sRead MoreKick back with your friends and enjoy an American meal at Bassett's. Those looking for a meal that's low in fat won't find it at Bassett's, where hearty, tasty meals come first. Drinks here are readily available, so you can enjoy a glass of red or try something new. Little guys and gals will also love dining at Bassett's, which offers a family-friendly environment (and menu). Large groups will appreciate Bassett's for its ability to seat them quickly. Take your meal to the next level on the patio at Bassett's. No need for a wardrobe change when you hit Bassett's — it's strictly casual. Or, take your grub to go. Catering is also available if you'd like to serve Bassett's' tasty dishes at your next party. At Bassett's, you can park quickly and safely in a lot next door. Bassett's is a prime location for cyclists to park their bikes and enjoy a bite to eat. It will typically cost you about $30 to enjoy a meal at Bassett's.19950 Fisher AvePoolesville, MD US
The Old Brogue Irish PubRead MoreFind old friends or make new ones at The Old Brogue Irish Pub — this welcoming Irish bar is a solid hangout. For those tired of trendy diets, The Old Brogue Irish Pub's lack of low-fat food is sure to make your stomach smile. The Old Brogue Irish Pub also provides alcohol, so diners don't have to worry about bringing their own bottle. Families will feel right at home at The Old Brogue Irish Pub with its kid-friendly menu and atmosphere. Celebrate the start of a great weekend at The Old Brogue Irish Pub's great happy hour. The Old Brogue Irish Pub provides seasonal outdoor seating — be sure to grab a chair before it's too late. Musical guests frequently perform here, so patrons can enjoy live tunes with their food. Take advantage of the lenient pup policy, and bring your four-legged friend to the restaurant. During the restaurant's weekend rush, waiting in line is the name of the game (so avoid Friday and Saturday nights if you're looking for something quick). Always five minutes behind schedule? Pick up your food to go instead. Catering makes it easier to organize any event, and The Old Brogue Irish Pub will ensure that it is delicious. Don't spend time searching for parking — patrons are welcome to use the adjoining lot. Prices at The Old Brogue Irish Pub are moderate — most diners plunk down about $30 per meal. You can stop by at practically any time, since The Old Brogue Irish Pub serves breakfast, lunch, and dinner.760 Walker RdGreat Falls, VA US
Glory Days GrillRead MoreGlory Days Grill in Sterling is known for its tasty eats. Low-fat fare is not available here, so leave some room in your diet. Don't go thirsty during dinner! Glory Days Grill also offers a splendid drink list featuring wine, beer, and more. At Glory Days Grill, kids of all ages are welcome. Glory Days Grill features some of the most affordable happy hour deals in town. Glory Days Grill will be able to accommodate your large party. Surf the web from your tablet or laptop on Glory Days Grill's complimentary wifi. On warmer days, you can take advantage of Glory Days Grill's al fresco patio seating. Between the music and the crowds, Glory Days Grill's noise levels can be intense. You may be better off finding a table during the week, as weekends at the restaurant tend to be packed. Catering services are also available. Getting your food to go is also an option. Tired of driving in circles? Head to Glory Days Grill for a bite to eat and find quick parking in the lot next door. Glory Days Grill is a prime location for cyclists to park their bikes and enjoy a bite to eat. The food here is super budget-friendly, too, with most items costing less than $15.21800 Towncenter PlzSterling, VA US
Mighty Mikes Grill and BarRead MoreA well-known restaurant in Sterling, Mighty Mikes Grill and Bar is the ideal location for flavorsome pub food. It's a favorite spot for guests interested in great food. If you're trying to plan ahead, most patrons will share that Wednesdays, Thursdays, and Fridays are the best nights to visit. It should be noted that casual attire is encouraged and though the prices are considered low, you won't sacrifice any quality. If you're in the mood for tunes, it does have a good juke box. It's a good option for large groups, dancing, and families with children. WiFi's available if you're trying to get some work done, and in addition to its convenient take-out menu, the restaurant even provides catering for events around town. Or, if you're looking for the perfect spot to unwind after work, it's got a phenomenal happy hour and a pretty broad selection behind the bar. A highly-regarded spot for lunch and late-night cuisine in Sterling Park, chances are you won't walk away from Mighty Mikes Grill and Bar disappointed. Don't worry about trying to find a spot on the street, as visitors to the restaurant do have access to a private parking lot nearby.22330 South Sterling BoulevardSterling, VA US
Velocity FiveRead MoreSituated in the Great Falls Chase neighborhood of Sterling, Velocity Five welcomes its cafe patrons with open arms. Velocity Five visitors can also take advantage of the many drink options offered here. Tots and tykes will be right at home at Velocity Five with its kid-approved food and ambience. The happy hour at Velocity Five is sure to impress. Enjoy the beautiful weather while you chow down — with outdoor seating, Velocity Five is a great summer destination. Have a large group? No problem. Head to Velocity Five for easy seating. Customers here often groove to live music or a DJ. Dance the night away to Velocity Five's live music. If your Friday or Saturday night plans include a trip to the restaurant, it's best to reserve a table before heading over. Diners who appreciate a no-frills environment come to Velocity Five in jeans and a hoodie. A catering menu is also available if you're looking to dazzle the guests at your next shindig. For those who prefer to travel by bike, Velocity Five is a great option due to its generous bike parking options. Your tab at Velocity Five will usually run to about $30 per guest.20789 Great Falls PlazaSterling, VA US
Applebee'sRead MoreApplebee's is serving up American favorites with a tasty tweak. With no low-fat options served, come ready to eat your heart out. A night out deserves a drink to celebrate, and Applebee's has the perfect selection of beer and wine to go with your meal. Score happy hour deals and steals at Applebee's. Wifi is on the house at Applebee's, so you can stay connected on your mobile device. Between the music and the crowds, be prepared for a lot of noise at this restaurant. Applebee's doesn't take reservations, so it tends to get especially busy on weeknights. No need for a wardrobe change when you hit Applebee's — it's strictly casual. Bring the Applebee's' great food to your place. For those in a hurry, the restaurant lets you take your grub to go. null Treating yourself doesn't mean breaking the bank, come taste the great dishes Applebee's has to offer. Paying with your major credit card is one payment option at Applebee's.45979 Denizen PlzSterling, VA US


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We researched just about every online weight loss program available, picked them apart, and delivered you the insider, no-nonsense, flat belly truths about the best ones.
PHOENIX, April 13 /PRNewswire/ -- Member Authority set out to find the best online diet programs to achieve three goals: lose weight fast, keep the pounds off, and keep your body healthy in the process. We ranked each program based on those same three factors, plus filled you in on a few other unexpected results.
Here's what we found:
Jenny Craig - Overall: 6.7 / 10
Short-term: 7.4, Long-term: 3.9, Healthiness: 8.7
The diet started out fairly effective for the first two to three weeks for most participants. However, it is suspected that most of the initial weight lost was due to water weight, which is temporary. The long-term effectiveness for participants was drastically reduced, often resulting in stopping early. Participants did feel the food was healthy enough, however the monotony and expense of having to buy their food was often a complaint. Visit: http://www.jennycraig.com
The Deceptive Diet - Overall: 9.1 / 10
Short-term: 8.9, Long-term: 9.6, Healthiness: 8.8
The Deceptive Diet started burning fat on the first day and didn't let up. There was extremely consistent feedback from participants - the diet works. This unexpected winner focuses on boosting your metabolism to lose the weight for you, so the pounds keep coming off over time. During this weight loss program participants reported feeling healthier, livelier, and more energetic than ever. Visit: http://www.deceptivediet.com
South Beach
|SOURCE Member Authority
Copyright©2009 PR Newswire.
All rights reserved


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Saks Fifth Avenue Retailer
Cotton Lolly Dress
- Elie Tahari
- Price on Inquiry
- Texture is the word this season. This cotton dress has embroidered style and then some. Round neck Short sleeves Concealed back zipper Back vent Fully lined About 24"" from natural waist Cotton Dry clean Imported Model shown is 5'10"" (179cm) wearing a US size 4. Colors: Violet


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King Size Sheets: King Size Sheet Sets, Quilt Covers, Mattress Toppers & Other King Size Bedding
Search this great range of king size sheets and other Furnishings related products. We've brought together a selection of king size sheet products for you to browse. Make searching easier and refine your search results by Price or Shop. Click on the product links to see more information.
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You look like someone who has had a rough morning chalk full of Four Lokos, a few packs of smokes, some Insane Clown Posse & too much baby momma drama.
Wow! Okay, in case you guys forgot about this guy from last week turns out I was right, apparently he really was trying to return the sign. Good to know. Odd, but good to know.
I'm not quite sure what my man here is doing with a street sign in Walmart. Maybe he is trying to act like he bought it and wants to return it. Maybe he is one of the hundred of idiots we've seen park right over a sign and he is being a good person and bringing it back in. I don't know, maybe you guys have some ideas. I'm lost, because clearly there is no sign to point me in the right direction now.
You see a g-string, I see a nice pie chart for budgeting….and her ass. We all see her ass.
People of Walmart is a humor blog that depicts the many customers of Walmart stores across the United States and Canada. Through funny photos and videos, People of Walmart is an entertainment blog in the Three Ring Blogs network that features over 30 of the funniest humor blogs on the internet. Walmart is the largest retail store in the United States and has millions of people visit stores each day wearing anything but proper attire.


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Glorious 14-Karat Gold 4mm Ball Stud Earrings with Gift Box & Authenticity Card
$15.00 Our Price
$199.99 Retail
Want to know a little secret? These 14kt gold studs have all the sparkle you need without the fuss and hassle you don't. With a gorgeous, smooth round base, you'll always have something to pair with a fun blouse or your best evening attire. For formal wear at VIP parties to a simple stroll in the park or a jaunt across town for an appointment, this deal will light up your look with sophistication and sparkle. Step out in shimmering style with this sizzling pair of studs! It works wonders as your go-to chic look. Want to know more? • Made with solid 14kt gold • Each measures 4mm DIA • Designed in a sphere shape • Push-back closures • Proudly made in the USA • Perfect gift for birthdays, anniversaries, and more • Includes Authenticity Card • Comes gift-boxed
Today's Deals
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Sports Bags
Do not compromise - price and quality meet here with the Clayfield Sports Bag - outstanding make quality and branding and delivered to you fast!
A good sized sports duffle bag printed with your brand or club logo will be a popular item with clients or members!
A single, eye-catching contrast panel is all the decoration the Sprinter Sports Bag needs
One of our newer sports duffle bags the Paddington has a fat contrast band down one side as a point of difference.
With stand-out panels and high-quality features, the Jump Sports Bag is sure to deliver!
A huge 58 litre capacity makes the Titan one of our most functional sports bags!
Featuring an impressive capacity, convenient opening and a truly sporting look!
The Flash Sports Bag belongs to a range that can be mixed and matched, - get a complete look for your next promotion!
Another ECO option made from 100% recycled materials this sports bag is a great way to get your brand and logo out there!
An attractive sports bag option for the discerning buyer - quality make and good branding space on the top of the bag.
A best seller the Travel Bag is not just for the holidays but also doubles as a good sports bag option.
The essential climbing or outdoor item, these bags are visually stunning


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Check out our Research by watching the Arts in 60 Seconds videos!
The Interdisciplinary Program in Religious Studies offers an Honors, Combined Honors and Major and Minor in Religious Studies.
See the University of Alberta Calendar for information on the requirements for the Honors in Religious Studies, Combined Honors or Major or Minor in Religious Studies.
Dr. Neil Dalal
About Religious Studies
Undergraduate Program
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Mushrooms are among the foods that I was convinced were terrible until around the time I went to college; through experiences outside of the house I found that mushrooms were actually delicious, despite my stubborn reaction when younger. Roasted mushrooms were always a favorite (I learned I had the same feeling about brussels sprouts).
This recipe is inspired by walking past the to-go foods at Whole Foods. Roasted balsamic mushrooms seemed like an easy preparation of vegetables, and we were pleasantly surprised. This is a quick and enjoyable recipe—feel free to double or triple the ingredients for weekly meal planning.


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Had a ocean front villa (under $200 per night) and the view was amazing. Great value, great beach, good pools and grounds and overall a better hotel than I expected.
Downside was I thought the food and drinks were expensive. Maybe it is the current dismal $USD, I dont know. Cabo across the board seems more expensive than it should be.
There are rotating drink specials and happy hours acorss the 6 or 7 bars so if you are diligent and dont mind walking the property, you can grab 2 for 1 on beers, margs, other cocktails and food specials pretty much the entire day. There was also a great breakfast/brunch buffet everyday that was well worth the price.


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Top Definition
Someone at a party who is essentially useless in terms of starting or maintaining a conversation in a group, interacting with others or providing any form of noticeably positive interaction. However, they help to give a party mass and so are like fodder.
Fred: "That party was alright, but what's up with Alice? She barely talked or did anything!"
James: "Yeah man, she's total party fodder."
James: "Yeah man, she's total party fodder."
by Babo Sang Pyo October 27, 2007


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AFC East
Print without images
Wednesday, March 9, 2011
Two years, two sports, too bad, Pat White
By Tim Graham
The dateline on the Associated Press story is Surprise, Ariz.
And who'd a thunk it?
According to the Associated Press, former Dolphins QB Pat White has retired from baseball.
In the span of less than two years, second-round draft choice
Pat White
not only couldn't stick with the
Miami Dolphins
, but also has dropped an entirely different sport.
White didn't show up for spring training with the Kansas City Royals and has
informed the team he's retiring from baseball
The Dolphins had big expectations when they drafted White 44th overall out of West Virginia in 2009. He was a dual-threat quarterback, brought in to augment their chic Wildcat offense. Only he wasn't a strong enough runner or an accurate enough passer in the NFL.
White played 13 games his rookie season. He ran 21 times for 81 yards. Take out his longest attempt of 33 yards and he averaged 2.4 yards a carry. White didn't complete any of his five pass attempts and was sacked once.
White's 2010 training camp began mysteriously
. He showed up a day late. The South Florida Sun-Sentinel spoke to White's brother, who informed the paper he was dealing with a serious off-field issue that never came to light.
Dolphins waived White as part of their final cuts
, opting not to keep a fourth quarterback in addition to
Chad Henne
Chad Pennington
Tyler Thigpen
White turned to baseball, with the Royals assigning him to their Fall Instructional League.
He'd been selected in the Major League Baseball draft four times: fourth round by the Los Angeles Angels in 2006, 24th round by the Angels in 2007, seventh round by the Cincinnati Reds in 2008 and the 48th round by the New York Yankees in 2009.


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Hilton Garden Inn Minneapolis/Maple Grove
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Is the Universe trying to tell me something?
... can't be good. Probably a brain tumor, I think. All day I keep hoping it will go away, but it doesn't. I imagine going to the doctor and her wanting to rush me into surgery. "Hold on," I'd say, "can't this wait until after I get back from Isle Royale?"
Monday morning I call the doctor and get a same-day appointment. They send in a young physician's assistant who asks a couple of questions and tells me I need to see an ophthalmologist. Today. But she won't tell me why. She ...
The Visit
... home. Here is the saga of his long journey. When we visited the kids in March, we found that a lizard had hitchhiked the 1800 miles from our home. Fast forward to late June and suddenly a lizard makes an appearance in the driveway. Now, with the understanding that this species is not found in Minneapolis and that the likelihood of a second lizard making the trip from Florida, we must assume that Bugsy is our ...
Day 1
Left at two o'clock. Our mileage is 52809. The drive is long. 4 hours and 30 min. I still don't understand how this blogging thing works. I like the drive because I just saw HORSIES! And scenery. I forgot what its like to drive this long. This is our longest road trip yet. We got a movie for the ride. It is Chiuaua the movie. (I KNOW its not spelled right. Gosh!) I am also excited to see all the different ...
Mall of America
... lunch at Dave's Famous BBQ and I had the best dessert at the Old Stone Creamery. I had the Peanut Butter Perfection - Chocolate ice cream, Reese's PB cup, hot fudge & a scoop of PB all mixed together. OMG, it was the best!!!
Back at the hotel for a little nap and then off for a nice dinner at the Old Spaghetti Factory!
Dinner at the Old Spaghetti Factory was good. The decor ...
Final Day in the States
... of a two-hour train ride to Leeds. Phew! I think that's all. I won't even begin to address the many orientation events I'm supposed to attend because it makes my head spin just thinking about them.
If all goes well the next time you'll hear from me I'll be on English soil. See you ...


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- Glenvil Acura
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text: Standard Register Co Company Profile (NYSE:SR) Analyst RatingsEarningsDividendsInsider TradesCompany ProfileSocial ActivityToday's Chart Consensus Ratings for Standard Register Co (NYSE:SR) (?) The ratings breakdown includes the most recent rating from each analyst that has rated the stock within the last twelve months. The ratings score is a calculation of the average number of sell, hold, buy and strong buy ratings (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). The consensus price target is a mean average of the most recent price target set by each analyst that has set a price target for the stock in the last twelve months.Ratings Breakdown: No ratings tracked in the last 12 months.Consensus Rating:N/A (Score: NaN)Consensus Price Target: N/A Analysts' Ratings History for Standard Register Co (NYSE:SR) Show: All Ratings For This Stock Only the Most Recent Rating From Each Brokerage No equities research coverage for this company has been tracked by MarketBeat.com Earnings History for Standard Register Co (NYSE:SR)DateQuarterConsensus EstimateActual EPSRevenue EstimateActual RevenueRelease LinkConference CallActions10/24/2014Q3($0.65)ViewListen 7/25/2014Q214$0.67$136.80 million$225.30 millionViewListen 4/25/2014Q1($0.83)$141.60 million$228.50 millionViewListen 2/21/2014Q4$1.14$143.60 million$242.00 millionViewListen 10/25/2013Q313($3.92)$145.70 million$199.30 millionViewListen 8/1/2013Q2 2013$0.25$155.10 million$136.80 millionViewListen (Data available from 1/1/2011 forward) Dividend History for Standard Register Co (NYSE:SR)No dividend announcements for this company have been tracked by MarketBeat.com Insider Trading History for Standard Register Co (NYSE:SR)Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionActions2/2/2015William C MartinMajor ShareholderSell124,696$1.38$172,080.48 1/29/2015William C MartinMajor ShareholderSell126,295$1.99$251,327.05 12/16/2014William C MartinMajor ShareholderSell5,487$3.32$18,216.84 12/4/2014Silver Point Capital L.P.DirectorSell12,200$4.07$49,654.00 11/26/2014Silver Point Capital L.P.DirectorSell1,100$4.30$4,730.00 11/7/2014Silver Point Capital L.P.DirectorSell13,800$5.01$69,138.00 9/18/2014Silver Point Capital L.P.DirectorSell1,800$5.21$9,378.00 9/17/2014Silver Point Capital L.P.DirectorSell7,800$5.43$42,354.00 9/16/2014Silver Point Capital L.P.DirectorSell1,700$5.52$9,384.00 9/15/2014Silver Point Capital L.P.DirectorSell2,100$5.59$11,739.00 9/12/2014Silver Point Capital L.P.DirectorSell12,000$5.82$69,840.00 6/11/2014Silver Point Capital L.P.DirectorSell230,200$5.02$1,155,604.00 6/11/2014William C MartinMajor ShareholderBuy200,000$5.00$1,000,000.00 6/3/2014William C MartinMajor ShareholderBuy11,100$10.31$114,441.00 5/30/2014Amy L ReillyVPSell3,000$5.00$15,000.00 5/8/2014Silver Point Capital L.P.DirectorSell8,600$6.33$54,438.00 5/7/2014Silver Point Capital L.P.DirectorSell184,000$6.60$1,214,400.00 4/11/2014Will & Testament Of John LastMajor ShareholderSell3,600$8.08$29,088.00 4/9/2014Will & Testament Of John LastMajor ShareholderSell12,400$8.08$100,192.00 4/2/2014Will & Testament Of John LastMajor ShareholderSell7,200$8.19$58,968.00 3/31/2014Will & Testament Of John LastMajor ShareholderSell7,200$8.06$58,032.00 3/27/2014Will & Testament Of John LastMajor ShareholderSell4,800$8.00$38,400.00 3/24/2014Will & Testament Of John LastMajor ShareholderSell4,800$8.43$40,464.00 3/21/2014Will & Testament Of John LastMajor ShareholderSell8,800$8.77$77,176.00 3/18/2014Will & Testament Of John LastMajor ShareholderSell5,577$9.41$52,479.57 3/17/2014Will & Testament Of John LastMajor ShareholderSell2,400$9.89$23,736.00 3/13/2014Will & Testament Of John LastMajor ShareholderSell2,371$10.66$25,274.86 11/20/2013Robert A PeiserDirectorBuy3,000$6.53$19,590.00 11/5/2013Robert A PeiserDirectorBuy2,000$7.54$15,080.00 8/29/2013John J Schiff JrDirectorBuy10,000$10.93$109,300.00 (Data available from 1/1/2013 forward) About Standard Register Co The Standard Register Company (Standard Register) focus on enterprise and middle market customers in healthcare, financial services, manufacturing, retail, and transportation industries. Standard Register's business is helps its customers to manage and execute their critical communications by utilizing traditional printing and both Internet-based and electronic communications. The Company operates two business segments such as Healthcare and Business Solutions. Healthcare serves hospitals and other providers of healthcare and related services. Business Solutions primarily serves customers in the financial services, manufacturing, retail, business services, and transportation markets. Corporate consists of unallocated selling, general, and administrative costs, which primarily include restructuring and other exit costs, pension benefit plan expense, acquisition and integration costs, and asset impairments. Headlines: (2/13) Standard Register Co (NYSE:SR) Up After Securing Customer Communications ServicesAgreement With Webster Bank (4/23) Standard Register Company Stock Downgraded (SR) (1/29) William Martin's Raging Capital Goes Activist On The Standard Register Co (SR) (8/1) Standard Register Acquires WorkflowOne (7/10) Standard Register Co. (SR) Reports Non-Compliance Notice from NYSE (10/4) Standard Register Co. (SR) shows signs of a major breakout (3/4) Departing Standard Register executive lands new public company gig (4/30) Standard Register Appoints New Officer (7/25) The Standard Register's (SR) CEO Joe Morgan on Q2 2014 Results - Earnings Call Transcript (2/26) Amy Reilly disposes of 22,125 shares of Standard Register Co (SR) stock Industry, Sector and Symbol: Sector: Consumer Goods Industry: N/A Sub-Industry: N/A Exchange: NYSE Symbol: SR CUSIP: Key Metrics: Previous Close: $1.0050 Day Moving Average: $0200 Day Moving Average: $0P/E Ratio: N/AP/E Growth: 0Market Cap: $N/ACurrent Quarter EPS Consensus Estimate: $-1 EPS Additional Links: View SR on Google FinanceView SR on Yahoo FinanceView SR's Company Profile on ReutersSearch for Standard Register Co on Google Standard Register Co (NYSE:SR) Chart for Saturday, October, 10, 2015


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- Weekly Users' Choice July 7, 2009
- Daily Feature July 1, 2009
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Author Comments
Rated 5 / 5 stars
best game ever !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Rated 5 / 5 stars
Finally some trophies!
Rated 5 / 5 stars
love it
Rated 5 / 5 stars
awesome game
Rated 4 / 5 stars
Bugs: I filled the suckerface guy with paints red orange and yellow then hit the button and my shockwave player crashed...so...yeah. :I
Also, when trying to fly away with the squirrel the first time it had an arrow prompt, so i clicked it and the screen went to black. I restarted the level and it worked perfectly, i think, it took a little bit of spam clicking at the edge of the cliff but i got it. :)
But those are the only bugs I found, unfortunately I didn't get to finish the second story line. :<


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Hai friends,
I am new for unity3d.In my application i need to post score on twitter .but i dont know how to integrate twitter in unity3d application. please any one give sample code or any suggestion.
closed as not constructive by Will May 21 '13 at 14:07
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Recent Meetups
September 24 · 6:30 PMHow to make Julia fly : write high performance code with JuliaThis talk will show you how to write the fastest possible Julia code. Well written Julia code can often reach near C levels of performance and Avik Sengupta discusses... Learn more
June 18 · 6:30 PMJulia is not [anything at ] all about being fast, but it helps!Julia is probably best known for its speed as compared to its 'rivals', Matlab, R and Python. By seeking to answer a seeminglyextremely simple question, Malcolm... Learn more
March 17 · 6:30 PMLooking inside JuliaAt this month's London Julia meetup, we welcome Simon Byrne, who has been contributing to Julia and various packages since it became an open-source project in 2012.... Learn more
Nov 18, 2014 · 6:30 PMNetworks, Data, Models and Statistical Learning in JuliaSimulation has become an important tool to understand real-world phenomena. It is also central to many statistical inference approaches, especially in the increasingly... Learn more
Jul 23, 2014 · 6:30 PMJulia Packages - A guide to what's available and how to create them.Julia has many of the strengths of both Matlab and Python but is quicker than both. There are lots of new an exciting packages being built in Julia and in this... Learn more
- See all past Meetups


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China Air Quality Deteriorates in First Half, Daily Reports
July 27 (Bloomberg) -- Air quality in China deteriorated in the first half, the first such decline since 2005, due in part to a recovery in economic growth, the China Daily reported today, citing statistics from the Ministry of Environmental Protection.
In the first half, 91 percent of days in 113 Chinese cities had air quality at the Grade II national standard or better, the newspaper reported. That was 0.3 percentage points lower than in the first half of 2009, according to the report.
The amount of inhalable particles was 0.091 milligrams per cubic meter in the cities, rising from 0.002 milligrams a year earlier, according to the report.
Increased construction and industrial projects, a surge in automobiles and more frequent sandstorms in the spring were the main causes of the deterioration of air quality, the newspaper reported.
To contact the editor responsible for this story: Bloomberg News at firstname.lastname@example.com


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He awakens in the dark forest of a mythical land with some type of leopard mask that he cannot remove. The only thing he remembers is his name - Guin - and that he is a warrior of unimaginable power. And when the two twins of Parros, innocent victims of a
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