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British Comedian John Oliver has said he's been forced to shut down his satirical prosperity gospel church, Our Lady of Perpetual Exemption, after viewers mailed sperm as their "seed" donations.
The former "Daily Show" regular posted a message on the website of his now defunct church explaining the reasoning behind its closure.
"We have still, miraculously, not broken any laws by promising you untold riches in return for sending us money. We're also not closing down because you all kept sending us actual seeds, even though we explicitly told you not to," wrote Oliver. more >>
One of the reasons I say that it is good for American Christianity to no longer think of itself as a "moral majority" is that such a mentality obscures the strangeness of the gospel. When a vision of Christian political engagement hinges on building a politically viable network of ideologically united voters, Christ and him crucified will tend to be a stumbling block, not a rallying point.
I'm sure that if a journalist had been present when Jesus said, "Man shall not live by bread alone," the headline the next day probably would have been, "Religious Leader Calls for Pullback from Agriculture Policy."
The call to a gospel-focused engagement is not a call to a retreat. On the contrary, it's a call to a more vigorous presence in public life, because it seeks to ground such witness where it ought to be, in the larger mission of the church. Even some sectors of religious activism chafe at the honest accounting of apostolic Christianity as a minority viewpoint in Western culture. Minorities do not exert influence, they will contend, on the culture or the systems around it. The temptation is to pretend to be a majority, even if one is not. more >>
Recent events have called into question the issue of obeying the government in all ways — even in all circumstances.
In the 13th chapter of Romans, Paul says that God has given us the government as a minister of righteousness. It is our duty to obey it. But we also see in Scripture that on occasion, when the government calls for one to disobey God, then civil disobedience is in order.
There's a great lesson to learn from one aspect of World War II related to distortions of Romans 13. I'm not calling anybody a Nazi, but consider this lengthy lesson, wherein the Nazis quoted Scripture in order to demand unquestioning obedience. more >>
A diverse group of clergy and legal experts sent a letter to President Barack Obama urging him to keep a rule allowing religious organizations with government grants to maintain hiring practices consistent with their religious beliefs.
Sent to the White House on Thursday, the letter pleads that President Obama reject calls by many progressive organizations to bar federal grants to religious organizations that use religious affiliation as a parameter for employment.
The letter was organized by the Institutional Religious Freedom Alliance and signed by liberals and conservatives, religious leaders and religious freedom experts. For instance, Franklin Graham, president of Samaritan's Purse and the Billy Graham Evangelistic Association; Ron Sider, president emeritus of Evangelicals for Social Action; and Douglas Laycock, Robert E. Scott Distinguished Professor of Law at the University of Virginia Law School, were among the 69 signers. more >>
The American Center for Law and Justice has sent out a legal letter supported by 81,500 Americans defending football team chaplains from the Freedom From Religion Foundation's claims that they're imposing their Christian beliefs on players. The ACLJ argued that if atheist professors are not considered to be posing an issue to students' rights, neither should sports chaplains.
"University students understand that they will be exposed to a variety of religious and nonreligious views on campus. Sports team chaplaincies pose no threat to the rights of university students to hold their own religious views, any more than does graduation prayer, or for that matter, a professor's avowed atheism," the conservative law group wrote in its letter.
"The Establishment Clause does not compel the expulsion of sports team chaplains who serve voluntarily to meet the spiritual needs of student athletes, any more than the Establishment Clause requires the razing of university chapels that exist to meet similar needs." more >>
Former Arkansas Governor and current Republican presidential hopeful Mike Huckabee said he is willing to go to jail on behalf of Kentucky county clerk Kim Davis, who refused marriage licences to same-sex couples.
Huckabee made the offer while standing beside the recently released Davis at a Tuesday rally.
"If you have to put someone in jail, I volunteer to go. Let me go. Lock me up if you think that's how freedom is best served," said Huckabee, as noted by CNN. more >>


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Pati's Blog: Latest Entries
I had fallen for the city of Puebla almost 20 years ago. And you know how that goes, sometimes when going back to things you loved while young and are nostalgic about, there's a risk of disappointment.
Just the first night I was back, I felt myself fall for it all over again. After days of scouting, eating, researching, testing and filming with Cortez Brothers, I left with a disorganized mental list of things I didn't even had the chance to try.
See, the charm is everywhere: from the history inhaled in each corner; to the talavera tiles splattered all over buildings, tables, vases and plates; to the food which makes you want to lick the plates clean, be it paper plates at markets – like this one holding cumin tamales with a side of peanut atole…
Continue reading Totally Unexpected: Cucumber Martini
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Totally Unexpected: Cucumber Martini
Cleaning and cooking nopales can seem challenging if you are not familiar with the ingredient. Truth is, cleaning them, can be a bit daunting at first. That's why I CANNOT wait for cleaned and diced fresh nopales to be readily available in grocery stores here in the US, just like they are in Mexico. But while that happens, let me give you some tricks.
First, to choose them, you want paddles that are bright green and although soft, not limp. The smaller the paddle the more tender it will be, but large ones are delicious too.
Continue reading Cleaning and Cooking Cactus Paddles or Nopales
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Cleaning and Cooking Cactus Paddles or Nopales
It's hard to think of Mexico without images of cactus plants. From landscapes to murals, to paintings, photos, plays, songs… and namely to the Mexican flag! Mexico's coat of arms has an eagle eating a snake triumphantly standing on a cactus plant. As legend goes, that sign led the Aztecs to their promised land, Tenochtitlán.
But you know what is even harder? To think of a Mexican table without cactus, or nopales, on our plates. They've been a crucial ingredient since pre-Hispanic times.
Though there are hundreds of varieties, the most common is the Prickly Pear cactus. It has fleshy leaves or paddles, that are used as a vegetable in salads, stews, soups, eggs, stews, all sorts of appetizers and even smoothies and juices -a really popular one combines nopales with orange juice and my mom is fond of adding fresh spinach to the mix. They are used as a base to mount other ingredients onto, as a wrapper instead of thick tortillas and as a filler or topper for tamales, quesadillas, tostadas… They are found from breakfast to dinner options and anywhere in between (continue for more information and photos).
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Cactus Paddles or Nopales
Growing up in Mexico City, I didn't know a single person who celebrated Cinco de Mayo, except for the people who lived in the state of Puebla. We didn't even get the day off! Sure we studied it in school–the unprecedented victory of a small Mexican militia against the large French army in 1862–but it was a short-lived victory, as the French won right back.
Fast forward 150 years to 2012: the French and Spanish are gone; Mexicans proudly celebrate Independence Day every September 16; yet, for reasons few of us can explain, Cinco de Mayo has become the greatest, most joyous, colorful celebration–for Mexicans living abroad. As strange as the nostalgia is, the longer I live abroad, the stronger the impact Cinco de Mayo has within my soul. These words fluff up like soft conchas right out of the oven, getting fluffier, sweeter and more comforting as the years go by.
Continue reading Creamy Poblano Soup
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Creamy Poblano Soup
Mexican chocolate is quite different from regular bittersweet chocolate sold throughout the world.
It is sweeter, yet with contrasting layers of flavor that seem to sweep your tongue in waves as you take a bite. It is also grainy, practically gritty. It is traditionally made from a mixture of toasted cacao beans, ground almonds, regular sugar and cinnamon.
Native from Mexico, in pre-hispanic times cacao beans were transformed into a chocolate paste. In that form, chocolate was combined with water and drank every day, by the liters, by Aztec Emperor Moctezuma. It was served for him, in hand carved precious mugs and spiced up with ground chiles and sometimes honey. Only the high tier of the Aztec hierarchy had access to it, on special occasions. It was only after the Spaniards arrived that it turned into a sweeter ingredient by adding the sugar, cinnamon and almonds.
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Mexican Chocolate
A couple weeks ago, right as I was setting up for one of my classes, "A Culinary Compass of Mexico," at the Mexican Cultural Institute, Alberto Roblest came over and asked me a great question.
"Pati, do you cook traditional Mexican recipes OR do you create your own?"
Alberto is doing a project with the support of The Office on Latino Affairs. It is called Hola Cultura and explores the contributions of Latinos to DC life and culture, from art to language to sports to cooking.
I think he meant for me to respond with an either or. He really did. Come on Pati, "traditional" OR "new," he insisted. But I kept answering "BOTH!" As I kept trying to explain why, I realized so wholeheartedly that both traditional and new not only describe my cooking style but also one of the many wonders of Mexican cuisine.
Continue reading Apple, Radish, Watercress Salad with Pistachio and Chile de Arbol
Chile Piquin goes by different names such as tepín, chiltepín, chilito, Chiapas (yes, like the state located in south east Mexico), diente de tlacuache (opposum's tooth), mosquito, pajarito (little bird), enano (dwarf), pulga (flea), amash, and chilpaya amongst others…
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Piquín Chile
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Wooden Spoons
Every few months, my family gets together with a Latin group of friends and their families for a pot luck.
This winter it was our turn. As tradition goes, the host brings the main dishes to the table and the others bring the rest. I eagerly announced my plans to share Mexican casseroles, also called cazuelas, budines or pasteles. The Mexicans couldn't hide their joy- "Pati! De veras? Budin Azteca? Cazuela de Tamal?!"- and quickly thought of other "very" Mexican sides to pair with them. The Argentines and Costa Ricans tried to understand what "Mexican casserole" meant and whether it was supposed to be any good. The Americans in the group (though they consider themselves Latin) were clearly not excited about it.
No doubt about it, casseroles have had their ups and downs in culinary history. Their weakest stand seems to have been in the United States, after being fashioned into "two-step-many-can" versions in the 1930 and '40s. But think of all the bright stars in the casserole universe: French cocottes enveloped in mother sauces; British potpies encrusting fillings as wet as British weather; irresistible Italian lasagnas layered with pasta; Peruvian causas with seasoned meat encased in mashed potatos; Greek spanakopitas with an extra-savory cheese-spinach mix covered with phyllo dough; Middle Eastern moussakas stacked with layers of eggplant; and the not-so-well-known, yet gloriously tasty Mexican cazuelas…
Continue reading Make It, Freeze It, Take It: The Mexican Casserole
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Make It, Freeze It, Take It: The Mexican Casserole
Continue reading Hoja Santa or Hierba Santa
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Hoja Santa or Hierba Santa

subset: commoncrawl


text: POPSUGAR Pets Too Cute For Words Too Cute For Words! by Pets 6/28/09 0 Shares Like us on Facebook Sign up for our daily newsletter > Follow us on Pinterest It's time to get clever! A picture is worth a thousand words, but those messages vary from person to person. What's wrong with this picture? Something? Nothing? Offer your thoughts, sayings, or quotes for this funny photo in your comments below, and I'll do a roundup next week of some of my faves. Image Source: Getty Read More Too Cute For WordsQuotable POPSUGAR, the #1 independent media and technology company for women. Where more than 75 million women go for original, inspirational content that feeds their passions and interests. Get Inspired With Our Living Newsletter Personalize Tech Vegetarian Food DIY Home Love and Sex Sign up with facebook or By signing up, I agree to the Terms and to receive emails from POPSUGAR. kelsea1102 6 years "....and after I fatten you up, Hansel, I'm going to eat you....." cplast 6 years A screenshot from the canine adaptation of "Planet of the Apes" Ellenora 6 years Princess the Dog protests animal cruelty in an unique way.


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Cuccinelli Can't Run from His Record on Restricting Birth Control
Category: Birth Control
At a campaign event, Virginia gubernatorial candidate Ken Cuccinelli was asked if, as governor, would he "support and sign personhood legislation that contains restrictions on birth control medication and birth control devices."
Cuccinelli's response? "I've never supported legislation that invades people's choices about contraception."
How about when you:
- co-sponsored so called "personhood" legislation that, if enacted could interfere with personal, private, medical decisions relating to birth control, access to fertility treatment, management of a miscarriage, and access to safe and legal abortion;
- voted against legislation clarifying that birth control was not a form of abortion (TWICE);
- co-sponsored a bill that would require parents of teenagers to be notified every time they sought information or treatment for STDs or contraception — violating their right to privacy;
- supported letting your boss decide whether you can get access to affordable birth control—even suggesting people should be willing to "go to jail" to fight expanding access to birth control; and
- said that birth control with no co-pay is a "sterilization mandate" and an example of tyranny.
You'll have to forgive us, if we're a little shocked that Cuccinelli has suddenly said he never supported legislation that interfered with people's personal medical decisions, it seems like he's made a career of it. No matter how hard he tries, Cuccinelli can't run from his record — and we won't let him.
Communications regarding the VA Governor's race on this site are paid for by Planned Parenthood Votes, and authorized by Terry McAuliffe, candidate for Governor.
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- Organization
- Leadership
- Reports
Dear Commander James Koutz:
Our Post and Unit has been working on writing another resolution to expand AL membership to all honorably discharged veterans. Through this process, we understand that "Resolutions tell leadership what members want. Resolutions help leadership make decisions." That quote is from the AL's guidebook on writing resolutions. We also understand that many before us have written resolutions regarding the expansion to invite all honorably discharged men and women to join the AL. Help us to understand why these resolutions have continually been turned down. What can we do to write a successful resolution before membership numbers drop lower? Thank you for your answer in advance.
Dear Legionnaire;
Please know that all resolutions forwarded to the Resolutions Committee are carefully considered and taken seriously. While all resolutions are not adopted, they are all definitely reviewed and considered in earnest.
The resolution that you discuss is much more complicated than most, as it calls upon The American Legion to change, not only our bylaws, but our charter as well. As you are aware our charter is congressionally mandated, and requesting a change involves more than just the approval of a resolution.
The issue of expanding the membership criterion of The American Legion is an ongoing discussion that the departments and Legion leadership regularly review. There have been many suggestions that include expanding membership to Cold War veterans, expanded Global War On Terror veterans, as well as your department's suggestion of expanding membership to all veterans.
The commission that handles this is the membership commission and the Internal Affairs Division.
Thank you for contacting the Legislative Division and please remember that we are here to support you, and all of the 2.4 million members of The American Legion.
Louis J. Celli Jr.
Director, National Legislative Division
Washington, D.C.
As you read, beauty can be incredibly important to your current and future physical appearance and so is understanding all the different techniques and products. This article hopefully took some of the confusion out about beauty, and you'll be able to incorporate some of the ideas into your own approach. The advice here is a great starting place.
Now that you have read the tips in this article you should feel more confident in your ability to determine what beauty regimin is right for you. These tips were carefully hand selected to help you learn simple basics in beauty and to apply some tried and true tips to your everyday beauty regimen.
I've never commented before on TAL's website. But a discussion on LinkedIn lead me to this particular Legislative Q&A article. Then I read the two comments above from "kopetpdzxp." It would appear, from the content, that there is no moderation of the comments as neither of them has anything whatsoever to do with the topic. Now...
Having said that, and admitting to a general ignorance of the legislative/parliamentary procedures of TAL, my thoughts on the topic... It would appear to me that the Resolutions Committee is THE decision making entity for our American Legion. If they control which items go forward, then they have, in fact, the power to decide which issue are allowed to be addressed by the membership. If they do anything more than review the proposed resolution for grammar/spelling and any outright illegal issues, then it appears to me that they are "voting" on whether the issue is heard. If a resolution is vapid, for example, let the greater body simply vote it down. If a resolution presents problems that the leadership considers insurmountable, let them explain that to the membership. If the membership overrides leadership's concerns, and the resolution is passed, that simply provides guidance to the leadership as to how the members wish it to proceed. Nothing is instantaneous.
So... being unmoderated, I presume this won't be read by many, either. Oh well. Vent complete.
M. Ingersoll you are absolutely right. Resolutions are put to Congress at the behest of the resolutions committee. They stop the resolutions - not Congress.
The American Legion is not as democratic as they would like everyone to believe. Why is Lebanon 1982 eligible and not Lebanon 1958. 1958 was awarded an AFEM but 1982 was a Navy/Marine Corps Expeditionary Medal and everyone, in Lebanon or not, is eligible. Can't get an explanation from anyone.


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Last night on K&C, Larry asked me about the improvement — after 5 down months — in New Home Starts. My answer was a single data point does not make a trend. Besides, rates are still historically cheap compared to the 1990s, when mortgages were primarily above 8%. (I also failed to mention in the allotted time that this is a notoriously noisy data series, with very inconsistent reporting standards; see this for more on that subject).
The way Real Estate's growth rate has cooled is very consistent with our expectation for a "slow motion slow down" in the economy. But I did not have time for the specifics as to why I believe a decelleration, and then outright reversal, in Real Estate will matter so much to the economy. Let's flesh this out a bit more:
Its long been a tenet of our economic outlook that the prime driver of the 2002-05 recovery has been the Fed. They slashed interest rates to 46 year lows, bringing the Fed Funds rate down to 1%, while cranking up the printing presses. Then, they kept rates low for a long time. Cheap money sent all sorts of hard assets — oil, gold, real estate, other commodities — soaring. This stimulus — and not tax cuts, as Rich Lowry incorrectly claims — was the key driver of the economy. Hey, I like tax cuts as much as the next guy, and personally benefitted ALOT from the dividend tax rate of 15% (before the AMT got me). But I calls 'em as I sees 'em, and it was historically ULTRA-low interest rates, and not the marginal change in top rates, that have been the prime domestic engine. (China was a close second, with the weak dollar right behind it).
Where was I? Oh, yes, Real Estate. When we first started prosletyzing this perspective of RE as the key, the skepticism was thick and the pushback was fierce. Now, this viewpoint has become fairly well established. Even the mechanism of MEW — Mortgage Equity Withdrawal — has gotten recognition as it put trillions of dollars into the hands of consumers, where it has been transmogrified into SUVs, new Kitchens, and HDTV plasma screens.
The mechanism for how this plays out is less well understood by Wall Street and the general public, and is slowly becoming accepted. It has begun to infiltrate the collective consciousness of investors. How the prime mechanism of the growth engine plays out, where its trending, and how it is likely to shift
over time will be the key to if we ultimately end up with an economic soft landing, a hard landing, or an outright crash.
To get a sense of how important MEW is, look at what GDP would be like without it. (Pretty scary, huh?). The usage patterns of consumers is the key to understanding where this can go.
Here's where it gets tricky: Despite the rise in interest rates and the cooling of real estate, US Mortgage Equity withdrawal has remained robust. According to an article in Economy.com by Zoltan Pozsar, in Q1 2006, gross equity extraction slipped sequentially from $1.033 trillion to $996.8 billion (annual run rate). This is still "way up in the stratosphere" to quote Joanie. MEW represented 8.4% of personal income in Q1, and is a very meaningful source of spending cash with incomes flat and real incomes negative.
The Penebscott Princess puts it this way:
"How does John Q. get his hands on some MEW? 1. sale of home. 2. refis 3. HELOCs. (In that order, btw.) Okay, since the sale of a home is the largest factor, what is truly bad news then, is a deceleration in the pace of home sales and of course, any evidence that prices are softening as well.
And we know that both are in the works. So yesterday's HMI release, a real dog, was unwelcome news, while acknowledging that it reflects new home sales only. Because face it. If they ain't linin' up to buy new ones, fat chance the used ones are flyin' off the shelves either.
Bottomline, the increase in interest rates is depressing sales and prices in the housing industry. In turn, this should eventually become evident in John Q.'s spending habits as the well runs dry. But for the moment, we now have one mystery solved as to where he's gettin' his funding: he's either sellin' or hockin' the ranch."
So how does all this fit in with our concept of a "slow motion slow down?" Spending patterns following mortgage equity withdrawals. The extra MEW green in consumers pocket is typically spent over 2 to 3 quarters. That implies the $249B or so extracted in Q1 will be spent from then to Q3. If Q2 slows even more, that gets spent from then thru Q4, and so on.
Even as MEW slows, it will still be stimulative, albeit at a decreasing rate, for the foreseeable future. This will continue until something stops the spending — most likely, a sentiment panic that freezes consumers from spending, with a religous epiphany involving saving money (hard to even imagine tho that may be).
I suspect that will occur slowly — much later this year or early 2007. The market's action in May could even be the beginning of discounting that consumer slow down.
Mortgage Equity Extraction, components
Source: Federal Reserve Staff working papers
Bottom line: Without something else to take the place of MEW, the consumer cannot drive the US economy at these levels for very much longer. Unless business spending ramps up dramatically, there is nothing else on the horizon to take the spending baton.
That spells trouble for GDP.
UPDATE: June 21, 2006 9:54am
The request goes up for the MEW GDP chart, and courtesy of Calculated Risk, here it is:
click for larger chart
UPDATE June 21, 2006 2pm
The WSJ picks this up in Market Beat: Mew Mix
Estimates of Home Mortgage Originations, Repayments, and Debt On One-to-Four-Family Residences
Alan Greenspan and James Kennedy
Federal Reserve Board, Staff working papers in the Finance and Economics Discussion Series (FEDS)
September 2005
US Mortgage Equity Withdrawal Remains Strong
Zoltan Pozsar in West Chester
Economy.com, June 16, 2006
Softer Housing Sector Is Seen,But Data Don't Point to Collapse
CHRISTOPHER CONKEY and MICHAEL CORKERY
WSJ, June 21, 2006; Page A2
Category: Economy, Investing, Markets, Real Estate, Retail, RR&A
Category: Corporate Management, Earnings, Investing, Markets, Psychology, Venture Capital
I frequently discuss Microsoft, and for many many reasons: They are a tech bellwether, a huge part of the S&P and Nasdaq 100 (and a smaller part of the Dow). They have also been a thorn in the side of new technology development and innovation, but now that so much of it has moved to the web, its gotten away from them.
This is a good thing.
One of the commenters said some time ago that I was "irrational in my hatred for Microsoft." That's hardly the case; Microsoft has put a lot of cash in my pocket, so at worst, I should be grateful to them for the windfall.
However, I am still an objective observer, and I believe that Mister Softee is not what most investors think it is: They are hardly innovators; rather, they copy other people's work relentlessly, until by default they own the standard. Their products are kludgy, bloated and anti-instinctive; They are hardly the elegant, easy to use software first dreampt up by science fiction writers decades ago.
From an investing standpoint, their fastest growth days are behind
them, yet they are hardly a value stock — yet. (Cody and I have disagreed about this for some time). The leaders of the last bull Market are rarely the leaders of the next. Despite this, Wall Street still loves
them, with 28 of
are widely owned by active mutual fund managers and closet Indexers.
Many people think of them as this well run money machine; In reality, they are very poorly managed by a group of techno-nerds with very little in the way of management skills. Even their vaunted money making abilities are profoundly misunderstood: Its primarily their monopolies in Operating Systems (Windows) and Productivity Software (Office) that generates the vast majority of their revenue and profits. Their Server software and SQL Database make money, but hardly the big bucks of Windows or Office. MSN is a loser, MSNBC is a dud, their Windows CE is hardly a barn burner — even X-Box has cost them billions more than it is likely to generate in profits over the next 5 years.
Lest you think its just me who thinks this way, consider no less an authority than Robert X. Cringely. He is the author of the best-selling book Accidental Empires (How the Boys of Silicon Valley Make Their Millions, Battle Foreign Competition, and Still Can't Get a Date). He has starred in several PBS specials, including Triumph of the Nerds: A history of the PC industry.
After Gates resignation, Cringely wrote this:
"Microsoft is in crisis, and crises sometimes demand bold action. The company is demoralized, and most assuredly HAS seen its best days in terms of market
dominance. In short, being Microsoft isn't fun anymore, which probably means that being Bill Gates isn't fun anymore, either. But that, alone, is not reason enough for Gates to leave. Whether he instigated the change or someone else did, Gates had no choice but to take this action to support the value of his own Microsoft shares.
Let me explain through an illustration. Here's how Jeff Angus described Microsoft in an earlier age in his brilliant business book, Managing by Baseball:
"When I worked for a few years at Microsoft Corporation in the early '80s, the company had no decision-making rules whatsoever. Almost none of its managers had management training, and few had even a shred of management aptitude. When it came to what looked like less important decisions, most just guessed. When it came to the more important ones, they typically tried to model their choices on powerful people above them in the hierarchy. Almost nothing operational was written down…The tragedy wasn't that so many poor decisions got made — as a functional monopoly, Microsoft had the cash flow to insulate itself from the most severe consequences — but that no one cared to track and codify past failures as a way to help managers create guidelines of paths to follow and avoid."
Fine, you say, but that was Microsoft more than 20 years ago. How about today?
Nothing has changed except that the company is 10 times bigger, which means it is 10 times more screwed-up.
Category: Corporate Management, Investing, Markets, Psychology, Technology
Category: RR&A
Category: Weblogs
Category: Markets
Category: Web/Tech


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TRUM: Six degrees of ... Matthew Berry?
Updated: April 3, 2009, 4:24 PM ETBy Matthew Berry, ESPN.com
Thoughts, Ramblings, Useless information and Musings for Friday, April 3, 2009
So in between fantasy darlings Grady Sizemore and Matt Holliday swinging bats, just after the great Buster Olney says his Clio Award-worthy line "This is Buster" and before we get to the much-more-attractive-than-me Alyssa Milano, there is a one-second shot of me in the latest ESPN.com fantasy baseball commercial.
Incidentally, I'm excited about being in a commercial with Alyssa Milano. Alyssa was in ...
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Jeremy Silberston: (on filming Foyle's War) We had to fly out of a little period airfield, but the conditions were perfect and Julian Ovenden as the pilot had a tremendous day. When the real pilot took the Spitfire back to Duxford, he gave us an impromptu air display, complete with loop the loops. It was glorious and everyone was hugely moved.
No one has discussed Jeremy Silberston yet. Start a conversation!
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Europe's ice research satellite CryoSat-2 is now in orbit. On 8 April at 15:57 (CEST), it was launched from the Baikonur Cosmodrome in Kazakhstan on board a Dnepr rocket.
Atmospheric chemistry satellite to ensure continuity of data for GMES
CryoSat-2, designed and built by Airbus Defence and Space, is measuring changes in the Earth's ice masses. The first data were unveiled this June
The technological advances that have allowed us to grow and manage crops, construct cities and infrastructures, and exploit the geological wealth of the Earth on an ever greater scale have also given us a firmer understanding of the world's…
Space in daily life
Guaranteeing continuous delivery of quality weather data in the decades to come


text: This place had a good feel before we arrived. The hosts were very pleasant to deal with for booking, very friendly and helpful. Added to that, they didn't even require an advance deposit and, when we arrived, told us we could pay the next day or so. The apartment was an excellent size and was pretty well equipped. Everything was... More


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The "green-impact" of the open innovation mode. Bridging knowledge sourcing and absorptive capacity for environmental innovations
This Policy Brief presents recent results on the impact that an open innovation mode has on European firms' environmental innovations. New evidence drawn from the CIS suggests that knowledge sourcing can increase the environmental innovation performance of firms. However, the way firms search for external knowledge and work to absorb it can lead them to different results, depending on whether they are involved in the adoption of an eco-innovation or the extension of their eco-innovation portfolio. Drawing on these results, policy implications for the European Research and Innovation Agenda are discussed.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
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|Aug 2013
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Phone: +34 954 48 8318
Fax: +34 954 48 8300
Web page: https://ec.europa.eu/jrc/en/institutes/ipts
More information through EDIRC
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Horbach, Jens & Rammer, Christian & Rennings, Klaus, 2012.
"Determinants of eco-innovations by type of environmental impact — The role of regulatory push/pull, technology push and market pull,"
Ecological Economics,
Elsevier, vol. 78(C), pages 112-122.
- Horbach, Jens & Rammer, Christian & Rennings, Klaus, 2011. "Determinants of eco-innovations by type of environmental impact. The role of regulatory push/pull, technology push and market pull," ZEW Discussion Papers 11-027, ZEW - Zentrum für Europäische Wirtschaftsforschung / Center for European Economic Research.
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- Davide Antonioli & Alberto Marzucchi & Sandro Montresor, 2014. "Regional Innovation Policy and Innovative Behaviour: Looking for Additional Effects," European Planning Studies, Taylor & Francis Journals, vol. 22(1), pages 64-83, January.
- De Marchi, Valentina, 2012.
"Environmental innovation and R&D cooperation: Empirical evidence from Spanish manufacturing firms,"
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Page 1
Recent de novo origin of human protein-coding genes
David G. Knowles and Aoife McLysaght1
Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland
The origin of new genes is extremely important to evolutionary innovation. Most new genes arise from existing genes
through duplication or recombination. The origin of new genes from noncoding DNA is extremely rare, and very few
eukaryotic examples are known. We present evidence for the de novo origin of at least three human protein-coding genes
since the divergence with chimp. Each of these genes has no protein-coding homologs in any other genome, but is supported
other primates. Furthermore, chimp, gorilla, gibbon, and macaque share the same disabling sequence difference, supporting
the inference that the ancestral sequence was noncoding over the alternative possibility of parallel gene inactivation in
multiple primate lineages. The genes are not well characterized, but interestingly, one of them was first identified as an up-
regulated gene in chronic lymphocytic leukemia. This is the first evidence for entirely novel human-specific protein-coding
genes originating from ancestrally noncoding sequences. We estimate that 0.075% of human genes may have originated
through this mechanism leading to a total expectation of 18 such cases in a genome of 24,000 protein-coding genes.
[Supplemental material is available online at http:/ /www.genome.org. The sequence data from this study have been
submitted to GenBank (http:/ /www.ncbi.nlm.nih.gov/Genbank/) under accession nos. FJ713693, FJ713696, and FJ713697.]
frequently arise through duplication of existing genes, or through
fusion, fission, or exon shuffling between genes (Long et al. 2003).
Originationof genes from noncoding DNA is extremelyrare:A few
eukaryotic examples are known in yeast and Drosophila (Levine
et al. 2006; Begun et al. 2007; Cai et al. 2008; Zhou et al. 2008) and
a very recent paper reported initial evidence for this process in
a primate ancestor (Toll-Riera et al. 2009). No cases have been
previously reported in human.
Analysis of the differential presence and absence of genes in
different genomes is hampered by incomplete genome sequence
and annotation artifacts (Clamp et al. 2007). We undertook a rig-
orous and systematic analysis of the human genome to identify
protein-coding genes with no counterpart in the chimp and ma-
caque genomes. Essential to this analysis is an extremely strict and
conservative set of criteria to exclude artifacts due to annotation
errors or sequencing gaps. The central pillar of this analysis is
a synteny framework to examine candidate novel genes. The
synteny approach allowed us to pinpoint the expected location of
thegenein otherprimategenomesandmeticulouslyexaminethat
region for evidence of protein-coding capacity. After careful ex-
clusion of all cases where there might be an ortholog in another
genome or where the annotated human gene is unreliable, we
identified three novel human protein-coding genes that have
originatedfrom noncoding DNA since the divergence with chimp.
Results and Discussion
Identification of human genes with no protein-coding match
in protein database or syntenic chimp genomic region
We built blocks of conserved synteny between human and chimp
using unambiguous 1:1 orthologs identified as reciprocal best
BLASTPhitswithnoother similarlystronghits.Thesyntenyblocks
we produced span 91% and 85% of the human and chimp ge-
nomes, respectively, and 21,195 (94%) of the 22,568 human pro-
tein-coding genes annotated by Ensembl are located within these
blocks. Because we only used 1:1 orthologous regions, lineage-
specific segmental duplications are excluded from this analysis.
We exploited the extremely high gene order conservation
between human and chimp to infer the expected location in
chimp of all candidate novel genes and to scrutinize that region of
genome for any evidence of the capacity to produce an ortholo-
gous protein. We defined the expected location of a chimp
ortholog of a human gene to be within 10 genes on either side of
the location of the human gene where the location was projected
from the human genome to chimp along the most closely located
1:1 orthologs (Fig. 1).
We initially identified 644 human proteins with no BLASTP
of at least the size of the human gene, withintheexpected location
of the ortholog in the chimp genome. These cases were excluded
from further analysis because we cannot exclude the trivial expla-
they have yet to be sequenced. For the remaining cases we used
BLATand Ssearch to examine the expected location of the gene for
nucleotide similarity indicative of an undetected but valid ortho-
log. For 150 cases we found a similar annotated protein that had
been missed in the initial BLASTP due to low sequence complexity
be present. We also excluded human genes with an annotated and
plausible ortholog in any other species (see Methods).
To minimize the chance that the gene of interest is itself an
annotation artifact, we only considered human genes that are
classified as ''known'' by Ensembl (i.e., they are also annotated in
databases other than Ensembl) and that have expressed sequence
tag (EST) support for transcription.
Finally, we searched the syntenic region in chimp and ma-
caque to identify the orthologous DNA. All of these stringent fil-
tering steps left three human protein-coding genes (CLLU1,
1Corresponding author.
E-mail firstname.lastname@example.com; fax +353-1-6798558.
Article published online before print. Article and publication date are at
1752Genome Research
19:1752–1759 ? 2009 by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/09; www.genome.org
Page 2
C22orf45, and DNAH10OS) which have no apparent ortholog in
any other species' genome, but where there is sequence similarity
at the nucleotide level at the expected location of the gene in
chimp and macaque (Table 1). Although the chimp and macaque
sequence from the syntenic location is highly similar, there is no
potential ORF from the same start codon or in the same reading
frame aligning to at least half of the human protein. Furthermore,
a BLASTP similarity search against all of GenBank confirms the
absence of annotated paralogs or orthologs of these genes in any
sequenced genome. We hypothesize that these genes have origi-
nated de novo in the human lineage, since the divergence with
chimp from ancestrally noncoding sequence.
Sequence characteristics and expression evidence
Each of these three genes is coded for by an ORF uninterrupted by
introns, though they do contain introns in the untranslated
regions (UTRs). All of the predicted proteins are short with lengths
ranging from 121 to 163 amino acids. Both the short length and
the lack of introns within the coding sequence are expected
properties of newly arisen genes because of the improbability of
the evolution of a long ORF and the complexity of intron splicing
signals. UTR introns are likely to be more easily acquired than
coding region introns due to lower constraints (Hong et al. 2006).
Little is known about these proteins and none of them has any
complex protein domains annotated.
The expression of each of these genes is supported by several
lines of evidence, including at least one complete, spliced cDNA
genes with functionality in brain and testis (Burki and Kaessmann
2004; Emerson et al. 2004; Begun et al. 2007; Potrzebowski et al.
2008; Rosso et al. 2008; Zhou et al. 2008). One of the novel genes is
expressed in male reproductive tissue and one was identified in
brain tissues, but they were also identified in many other tissues
(Table 1) and there is no statistical trend.
Human-specific mutations alter protein-coding capacity
To further investigate the hypothesis of de novo origins in the
differences between human, chimp, and macaque in the homol-
In particular, we focused on ''disablers''—sequence differences that
cause the inferred protein to be truncated or not translated at all.
We examined the corresponding chimp and macaque sequences
for the presence or absence of an ATG start codon, frameshift-
inducing indels that result in an early stop codon, or nucleotide
differences which result in an early stop codon (Figs. 2–4). In most
cases there are multiple disabling sequence differences in both
chimp and macaque. Several of these disablers are indels in chimp
or macaque that result in a drastically different hypothetical pro-
tein sequence, as well as early termination, which alone do not
prove that the ancestral sequence is noncoding because we cannot
orient the changes (the available data are uninformative of the
ancestral sequence), but which lend credence to the inference that
the sequences are noncoding. Critically, for all three of the human
disabler and that the critical sequence difference is supported by
high-quality sequence traces in all three genomes (Figs. 2–4; Table
1). To further confirm this we resequenced the DNA in the three
orthologous regions in one chimp individual and verified the
critical, shared sequence differences (GenBank accession numbers
FJ713693, FJ713696, FJ713697). We also searched the NCBI trace
databases of all other primates for sequence matches to the gene
Figure 1.
coding gene. The expected location of a gene is indicated by green shading and was defined as a 10 gene window on either side of the gene of interest
projected onto the syntenic location in the other genome. Candidate genes were excluded if there was a sequencing gap in the expected location (or
local inversions that rendered the expected location ambiguous) or similar sequence at the expected location with no clear exclusion from producing
a protein.
Schematic of analysis pipeline. The expected location of genes with no BLASTP hit was scrutinized for any evidence of a homologous protein-
Genome Research
Novel human genes
Page 3
Table 1.
Novel human protein-coding genes and supporting evidence.
Gene name
Ensembl ID
chimp ORFa
Expression support
and tissueb
Primate shared
Other major
sequence differences
Presence of enabler in
other human complete
genome sequencesd
EST/cDNA: Blood (AJ845165,
AJ845166); UniGene: Blood,
embryonic tissue, eye, lymph,
lymph node, muscle, pharynx,
tonsil (Hs.339918)
1-bp indele
Macaque: 4- and 1-bp
Sequence available and
enabler conserved in all
1 syn.;
1 nonsyn.
87 (25 amino acids
align with human
EST/cDNA: Kidney, other
DA635985); ArrayExpress:
Sperm, lung (E-GEOD-6872,
stop codon
Chimp: 1-bp indel;
Macaque: lacks ATG
start codon; 4-bp indel
Reverse strand is available
and conserved in Venter
1 nonsyn.
90 (75 amino acids
align with human
EST/cDNA: Hippocampus
(AK127211); UniGene: Blood,
embryonic tissue, eye, lymph,
lymph node, muscle, pharynx,
tonsil (Hs.339918)
10-bp indel
Chimp: 2- and 1-bp indels;
Macaque: lacks ATG start
codon; 13-, 8-, 1-, and
1-bp indels
Reverse strand is available
and conserved in Venter,
Watson and HuAA
1 syn.;
1 nonsyn.
aLength in codons of longest in-frame (alignable) ORF starting from any ATG in the region.
bType of data/database is listed followed by tissue information with database identifiers in parentheses. Underlined accession numbers are full-length, spliced cDNA.
cShared disablers are sequence differences shared by chimp, gorilla, orangutan, gibbon, and macaque that eliminate the capacity to produce a protein similar to the human protein.
dIndependently sequenced whole genomes: Venter, Watson, HuAA, HuBB, HuCC, HuDD, and HuFF. All data are listed where available.
eNot shared with orangutan.
Knowles and McLysaght
1754Genome Research
Page 4
and macaque is also shared with gorilla (Gorilla gorilla) and gibbon
(Nomascus leucogenys), and two are also shared with orangutan
(Pongo pygmaeus albelii; one was not shared) (Table 1). In all cases
there is high sequence quality (Supplemental Fig. S1). Shared se-
quence differences between chimp, macaque, and other primates
are likely to be ancestral rather than independent parallel muta-
tions, and so, we infer that the ancestral sequence was noncoding.
Human–chimp sequence divergence
We measured the sequence divergence of these human ORFs com-
pared to chimp to search for clues as to the presence and nature
of constraints acting on their evolution. We examined the align-
ment of the human and chimp nucleotide sequences (Figs. 2–4)
and identified a total of 12 nucleotide
substitutions between human and chimp
(pooled over all three genes). Using ma-
caque to orient the changes, we observed
that seven of the substitutions occurred
in the chimp lineage and five in the hu-
man lineage. Of the human-specific sub-
and two are nonsynonymous. The chimp
DNA is noncoding so it is not strictly
possible to consider synonymous or non-
in human (i.e., in an intact ORF). In this
way we can infer that of the seven chimp
substitutions, four are synonymous-like
and three are non-synonymous-like. The
amount of sequence divergence between
human and chimp in these regions is low
(just under 1%), which is not surprising
given the close relationship of the two
of non-synonymous-like substitutions) is
higher in the chimp lineage, which is
consistent with the hypothesis that these
regions are noncoding DNA in chimp.
However, there is no statistical power to
measure the significance of this obser-
Support from peptide databases
expression evidence, we sought further
support for the veracity of these protein-
coding genes because of the possibility
that they are noncoding RNA or the pos-
sibility of contamination of transcription
pressed pseudogenes (The ENCODE Proj-
ect Consortium 2007). Many proteomics
studies extract proteins from healthy
plement of proteins by sequencing short
peptides through various methods (Roe
and Griffin 2006). These data are thus
a direct verification of the presence of a
translated gene product. We searched the PRIDE (Martens et al.
2005) and PeptideAtlas (Deutsch et al. 2005) databases of short
sequenced peptides with the gene names and found that all of the
three genes have peptide matches indicating true protein-coding
activity (Table 2). In all cases the peptides were sequenced from
blood plasma samples. Each of these peptide matches is unique to
these genes in that they do not display significantsimilarity to any
other proteins in all of GenBankor to any hypothetical translation
of the human genome, other than themselves, even with a very
loose E-value threshold (Table 2). C22orf45 and DNAH10OS have
two sequenced peptides each, and in the case of C22orf45, pep-
tides uniquely matching this protein were identified in nine dif-
ferent experiments (Table 2). The peptide matching CLLU1 was
detectedatotalof903timesinthree differentsamples(PeptideAtlas
accession number PAp00140670).
Figure 2.
synteny between human and chimp chromosomes 12. Genes are indicated by rectangular boxes and
the region of chromosome is indicated by a horizontal line. Unambiguous 1:1 orthologs that were used
to infer the synteny block are shown in red. One gene in this region, chronic lymphocytic leukemia up-
regulated gene 1 (CLLU1), had no BLASTP hits in any other genome and is shown in green. (B) Multiple
sequence alignment of the gene sequence of the human gene CLLU1 and similar nucleotide sequences
from the syntenic location in chimp and macaque. The start codon is located immediately following the
first alignment gap, which was inserted for clarity. Stop codons are indicated by red boxes. The se-
quenced peptide identified from this locus is indicated in orange. The critical mutation that allows the
production of a protein is the deletion of an A nucleotide, which is present in both chimp and macaque
(indicated by an arrow). This causes a frameshift in human that results in a much longer ORF capable of
producing a 121-amino acids-long protein. Both the chimp and macaque sequences have a stop codon
after only 42 potential codons. (C) Alignment of the region around the critical human enabler-mutation
from gorilla, gibbon, and orangutan. For gorilla, gibbon, and orangutan the trace database accession
number is shown on the right. The disabler is also shared by gorilla and gibbon indicating it is ancestral.
Sequence changes in the origin of CLLU1 from noncoding DNA. (A) Region of conserved
Novel human genes
Genome Research
Page 5
presence of a protein product, they also confirm that the human
protein coding sequence extends beyond the critical shared dis-
ablers of other primates, i.e., that the unique coding sequence
granted by the enabling human-specific sequence differences is
actually translated (Figs. 2–4; Table 2). In particular, the human-
specific enablers are spanned by the sequenced peptides in
C22orf45 and DNAH10OS (Figs. 3, 4).
Nonsense mediated decay (NMD) requires one round of
translation in order to recognize any premature termination
codons (Stalder and Muhlemann 2008). Therefore, even ''non-
sense'' genes will produce at least one
protein. However, the chances of sequenc-
ing this aberrant protein are slight. The
identification of each of these peptides
in multiple experiments demonstrates
that the proteins have been translated
and produced in sufficient abundance to
be detectable in the protein sequencing
survey, and so we infer they are present at
ample levels to have an impact on the
Human population polymorphism
In addition to the standard human ge-
nome sequence, several individual ge-
nomes have been completely sequenced
et al. 2008). We examined each of the hu-
man genome sequences available through
Ensembl for the presence of the criti-
cal enabling sequence difference that we
had identified in the standard genome
sequence (Table 1). There was no poly-
morphism at this site in any of the avail-
able data for any of the genes.
We also checked HapMap for single
nucleotide polymorphisms (SNPs) with-
in each of these ORFs (Table 1). A total of
five SNPs were identified in the coding
regions of these genes, three of them
nonsynonymous. With such small num-
bers of SNPs there is no statistical power
to test alternative evolutionary models,
such as the action of selection or con-
Evidence of a selective sweep around
these loci would further support the func-
tionality of these genes in human if it
were found. However, we did not detect
any such evidence. We queried the anal-
ysisoftheHapMapphaseII dataavailable
through Happlotter (Voight et al. 2006)
and found that none of these loci was
detected by genome-wide screening of
HapMap data for evidence of recent pos-
itive selection. Williamson et al. (2007)
conducted a genome-wide search for evi-
dence of complete selective sweeps and
listed the top 101 regions with the stron-
gest evidence for a recent selective sweep.
None of the genes discussed in this letter falls within 100 kb of any
of the proposed centers of these sweeps (the reporting threshold
adopted by the authors), but CLLU1 is about 250 kb away from
a sweep detected in the Chinese samples. Neither of the other
genes was within 10 Mb of any of the detected sweeps.
De novo origins of at least three human protein-coding genes
from ancestrally noncoding DNA
The genes coding for the three proteins, CLLU1, C22orf45, and
DNAH10OS, are novel human-specific genes supported by several
Figure 3.
Region of conserved synteny between human and chimp chromosomes 22. One gene in this region,
C22orf45, had no BLASTP hits in any other genome and is shown in green. (B) Multiple sequence
alignment of the gene sequence of C22orf45 and similar nucleotide sequences from the syntenic lo-
cation in chimp and macaque. The arrow indicates the location of an in-frame stop codon shared by
chimp and macaque that would result in premature termination (red box) irrespective of the other
disablements. The codons highlighted with a yellow box indicate the stop codon including all dis-
ablements (indels) in chimp and macaque for the reading frame starting from the same location as the
human start (note the ATG start codon is absent in macaque and that the frameshifts mean the hy-
pothetical protein sequence is drastically altered). (C) The disabler is also shared by gorilla, orangutan,
and gibbon indicating it is ancestral.
Sequence changes in the origin of C22orf45 from noncoding DNA. As in Figure 2: (A)
Knowles and McLysaght
1756Genome Research


text:
World War Z ratings/spoilers
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July 27 2013, 11:30 AM
Fleet Captain
Location: Haifa, Israel
Re: World War Z ratings/spoilers
The original ending does make much more sense than Lindeloff's ending, but to have another zombie carnage/battle scene after Israel would indeed be just too much.
It looks like the whole script was a mess at any part of the filming, with both endings. The original script might've worked if the Israel part would've been scaled down significantly or even made the part where Brad Pitt discovers stuff about zombies, without major battle scenes. The new ending fits better what comes before it, but it doesn't make sense, so instead of enjoying the tense and pretty well filmed scenes, I was just thinking "Whaaaaat?" through the entire WHO part.
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Mathematics is physics without a purpose
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text:
We created Pandora to put the Music Genome Project directly in your hands
It's a new kind of radio –
stations that play only music you like
Let Me Be Myself
Features of This Trackelectric rock instrumentation
a subtle use of vocal harmony
mild rhythmic syncopation
major key tonality
electric rhythm guitars
acoustic rhythm guitars
prominent percussion
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
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I'm me.
Let me be myself
Society: Be yourself.
Society: Not like that.
I know I'm different... . and that u don't like the real me but alot of people love the real me so let me be me not a fake me that I have been just so u wouldn't make fun of me.... everyone is different


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The model was snapped leaving the Highgate branch of Côte this week
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10th Avenue Inn Bed and Breakfast
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Goonies Never Say Die
... extreme contrasts of forest, mountain, ocean... Shall I say all of these qualities make this place dreamy and romantic???
As much as I want to stay here for a little while longer, I have to move on to my next location. The drive is long... Where should I go next? Well, you have to stay tuned...
Go out and do some exploration and have some adventures!!! Add some spice to your life, because it is too good to waste...
Other places to stay in Seaside
Shilo Inn Suites Seaside East900 South Holladay, Seaside | 2 star b&bfrom $85
Riverside Inn430 S. Holladay Drive, Seaside | B&Bfrom $55
Anderson's Boarding House208 N. Holladay Drive, Seaside | B&Bfrom $79
Summer House1221 N. Franklin Street, Seaside | B&Bfrom $55
The Gilbert Inn341 Beach Drive, Seaside | 3 star b&bfrom $139


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This site for a clothing company makes good use of a strong, but relatively common layout. I particularly like the consistent card theme, even down to the dark green hue of the background that's reminiscent of a card table.Posted in Web Design → Misc
An appropriately designed site for a front-end developers conference, I like the consistent theme and use of typography. The caricatures of the speakers are a novel way to add illustrative interest.Posted in Web Design → Design
A gorgeous design site that's simply there to get some free design elements out there! I love the intuitive layout and snapshots of different design and UI elements, while the man with the pipe adds a certain character to proceedings.Posted in Web Design → Design
A solid and clean site for a web development agency that makes a strong first impression. The use of white space and straight lines makes a good statement. The large slider gives a snapshot of all of the aspects of the agency and everything that they can help you with.Posted in Web Design → Design
Dainty is a site template suitable for businesses, applications, and portfolios. It comes with seven (7) color schemes to choose from as well as a filterable portfolio(s), timthumb and extensive documentation.Posted in Web Design → Misc
A fascinating site that immediately draws you in with its initial drastic minimalism. I love the way the navigation works, taking you carefully through an explanation of the site. The use of typography and design really helps to set the bar for this site.Posted in Web Design → Design
Here we have a slick and stylish site for a design agency. I really like the swish background and clear descriptive header. The intuitive layout helps potential clients to understand the process.Posted in Web Design → Design
A clean and dynamic site for a web design agency that lays out its process in a clear and concise way. The restrained use of colour is good, as is the use of icons and official logos.Posted in Web Design → Design
A slick and clean site for a web design agency. The way the colour scheme changes with each portfolio example is excellent. I really like the intuitive layout and stylish navigation bar.Posted in Web Design → Design
Garnish is a clean-cut, straight to the point, simple to use portfolio theme. The uncluttered, one-page, ajax-powered portfolio is perfect for placing your most important work directly in front of your potential clients. If you have ever used a "coming soon" page in place of your portfolio on account of being too busy, Garnish is for you. It's simple, convenient and to the point. If you're the modifying type, it's a pretty decent blank canvas too!Posted in Web Design → Corporate
A beautiful site that gives the user access to fantastic user interface elements. I love the brutally clean and minimal design. The quality of the Twitter icon here really helps to grab your attention, as do the sleek buttons.Posted in Web Design → Design
A fabulous fashion site that exemplifies quirky and artistic web design. I love the illustrative style and the overall style of the site. A few more instances of colour use could help to add interest and emphasis to certain elements.Posted in Web Design → Misc
A fantastic site for a wine company, I love the bright and clear photography - it really makes an impact. The design is consistent and the layout is intuitive, both help to engage any visitor to the site.Posted in Web Design → Food
A fantastically intriguing site for an independent film. I love the huge slider that features interesting taster stills from the film itself. The colours work very effectively, as does the smooth and intuitive layout.Posted in Web Design → Misc
A simply gorgeous and effortlessly clean site for a web designer. I love the bright and stylish design and use of interesting icons and buttons. The light colours and sense of humours helps to draw you in.Posted in Web Design → Design
This fascinating design just had to be included! While it's not the most clean design, it has a certain charm. I particularly like the woollen globe and variety of colour.Posted in Web Design → Misc
A stunning site that draws you in immediately through sheer intrigue. I love the use of typography and the strong and consistent colours and design. The dramatic emboldening effect that scrolling over text has gives you a strange sense of power.Posted in Web Design → Design
A gorgeous example of a fashion site, Twelve Saturdays makes good use of typography and intuitive design. The only issue for me is the way the footer keeps running away from you!Posted in Web Design → Misc
A simply beautiful site for a designer that flows seamlessly to draws you in. I really like the strong and consistent theme and little details throughout. The gallery sections perfectly exemplify the designer's style and add great interest to the experience.Posted in Web Design → Design
A great site for a web and front-end designer based in Italy. I particularly like the use of blue as a strong highlight colour and the consistent theme of the site. The layout is intuitive while the dark background helps it to stand out from the crowd.Posted in Web Design → Design


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Equine Welfare & Legislation
Hialeah, Florida, Horse Found Slaughtered
January 09, 2015
Police said an owner found his horse slaughtered in his barn when he went to feed then animal on Jan. 7.... Read More
Arizona Authorities Probe Alleged Animal Cruelty
January 09, 2015
Several horses are receiving rehabilitative care after being seized by Maricopa County, Arizona, authorities.... Read More
Couple Files Lawsuit Over Horse, Donkey Deaths
December 29, 2014
The lawsuit alleges a Wisconsin county is responsible for the deaths after the animals were allegedly unlawfully seized.... Read More
Good Horse Keeping and Other Advice From Equine Rescuers
December 24, 2014
Rescue operators share advice on small steps owners can take to keep their horses out of less-than-ideal situations.... Read More
WVRC Eyes Independent Review of Head-On Collision
December 19, 2014
The Dec. 13 collision led to a horse being euthanized after a race at Hollywood Casino at Charles Town Races.... Read More
Spending Bill Maintains Horse Slaughter Ban
December 18, 2014
The bill will effectively prevent any horse slaughterhouses from opening until Sept. 30, 2015.... Read More
Second Saddle Research Trust Conference Held in England
December 14, 2014
Researchers examined, discussed, and debated the latest research on saddle-related welfare and performance issues. ... Read More
Researchers Identify Signs a Painful Donkey is Improving
December 14, 2014
Scientists behind a new study have identified behavior changes donkeys show when they experience pain relief.... Read More
Aftercare Alliance to Award $2.4M in Grants
December 13, 2014
The Thoroughbred Aftercare Alliance will award $2.4 million in grants to its 42 accredited facilities for 2014.... Read More
Lawsuit Targets St. Louis Cab Regulators
December 12, 2014
The lawsuit alleges that the St. Louis Metropolitan Taxicab Commission failed to regulate horse-drawn cabs in that city.... Read More
N.Y. Congressional Delegates Split on Carriage Ban Ordinance
December 12, 2014
The proposed law would ban horse-drawn carriages from New York City's streets.... Read More
NYC Council Gets Horse Carriage Ban Ordinance
December 08, 2014
The New York City council received the proposed ordinance to banish horse-drawn carriages from city streets Dec. 8.... Read More
Saylor Joins Thoroughbred Retirement Foundation Board
December 07, 2014
Thoroughbred owner and businessman Paul Saylor has been elected to the board of directors.... Read More
Owners Seeking Restitution in Florida Horse Feed Recall Case
December 05, 2014
Owners who believe their horses were affected by tainted feed are seeking restitution from Lakeland Animal Nutrition.... Read More
2015 Racehorse Welfare and Safety Summit Scheduled
December 05, 2014
The summit will be held July 8 at Keeneland and is open to the public. A live webcast also will be available.... Read More
Horses Removed in New Jersey Cruelty Case
December 05, 2014
A herd of horses is receiving rehabilitative care after being removed from a farm operated by a Standardbred trainer.... Read More
Montana Police Probe Horse Shooting
December 04, 2014
Montana authorities are investigating the fatal shooting of a Quarter Horse near Butte.... Read More
Complaints Prompted FDA Scrutiny of Equine Ulcer Products
December 03, 2014
A series of complaints prompted the FDA to warn several firms that were marketing ulcer treatments without its approval.... Read More
Beasts of Burden: Africa's Working Horses and Donkeys
December 02, 2014
Veterinarians and researchers take a look at cases very different than those seen in developed countries.... Read More
Salt Lake City Bans Horse-Drawn Carriages
December 02, 2014
The city council banned commercial horse-drawn carriage rides from the Salt Lake City streets last week.... Read More
SPANA Launches Appeal to Tackle Diseases in Working Equids
November 30, 2014
The charity is raising the funds needed to vaccinate against and treat life-threatening diseases such as tetanus.... Read More
The Equine Necropsy: A Sensitive but Important Topic
November 26, 2014
A necropsy is not something most horse owners contemplate until faced with the death of a horse.... Read More
Sweeping New Racehorse Drug Rules Approved in New York
November 24, 2014
The agency says the rules are intended to protect the integrity of New York's wagering system and racehorses' health.... Read More
Funds Committed to Aftercare via Breeders' Cup Pledges
November 23, 2014
Thoroughbred owners and trainers have pledged more than $45,000 to racehorse aftercare.... Read More
California Horse Owner Faces Multiple Cruelty Charges
November 21, 2014
A California man is facing charges for allegedly maltreating dozens of horses residing on two of his properties.... Read More
Related Topics
Related Multimedia & Downloads
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Equine Welfare: Lessons Learned
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News/Interviews Video
Dr. Temple Grandin on Fear in Horses
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FDA Approval Significance
Farm Call: Your Questions Answered
How to Keep Your Horse Safe During the 4th of July
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Blog: Horse Sense (and Sensibility)
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- The Sacred Art of Puttering Around with Horses
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- Veterinary Schools on Instagram
- Slobber-gate: What Caused My Horse's Excessive Salivation?
- Settling In … Slow Snorts and So Many Feed Choices
- 14 More Considerations for Preventing Horse Barn Fires
- Picking Up Where I Left Off With Horse Ownership
- Life Is Short: Just Get the Horse


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Im frankly concerned now since I can no longer see my goods!lol!Ā
What toilet paper wont leave a fluffy paper trail behind? Ive been using Scott Ultra Soft and am not so pleased.. Ā
Im frankly concerned now since I can no longer see my goods!lol!Ā
What toilet paper wont leave a fluffy paper trail behind? Ive been using Scott Ultra Soft and am not so pleased.. Ā
( . Y . ) Gold!
OMG that is one of my pet peeves.┬Ā I so feel your pain.┬Ā I went through so many brands of TP trying to find one that won't leave lint on me.┬Ā
we use Charmin ultra strong - the kind in the mostly red packaging.┬Ā I find that it does not leave me linty.┬Ā
3 angel babies - only briefly in my womb, forever in my heart
Mommy to Liliana since 10/2/08 + Annabella since 11/11/11
Married to Miles since 11/11/08
yeah we use charmin, i dont use toilet paper on my son though, i use baby wipes still. is it true that they cannot be flushed though??
Benjamin & Jacqueline 1.29.11 <3
Joshua Christopher 5.6.08
Avianah Lillian Cleopatra 11.6.11
I love Royale.┬Ā And the kitties on the package are darn cute too. lol
Check me out on fb!
Mama's Random Fluff n' Stuff
My etsy
Charmin it is! Thanks guys;)
( . Y . ) Gold!
DSS-Connor(10) DD-Coralee (9/19/07) DS-Haakon(2/10/09) DS-Essex(12-23-11**8lb14ozVBA2C!) #4 due July 2014
Proud momma to Cole Ryan (May 24, 2009) &
Brody Pierce (November 16, 2011)
Megan- 3 generations of DH's family, within 100 yards - DH, FIL, and my 3 boys: DS (4), DSS (19), DS (born 12/5/11).
I use Scott one ply lol, BUT I always follow up with a baby wipe because I can't stand the though of anything being left behind lol!
And when I go to the OB and know I am going to be checked internally I carry a bag of baby wipes in my purse and use one beforehand after I give my urine sample. ┬ĀI am a little ocd about it actually.
42 year old homeschooling mom to four wonderful kids: 12/89 11/91, 4/01, 2/02, and Baby Ben born 11/12/11 !


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Hello Everyone, and welcome to the October issue of FAST LANE
BIKER. As always the biggest motorcycle event in the Tri-State area Cape Classics Roar to the Shore was a huge success. As always and like we always do were dedicating the entire issue to Wildwood bike week. Our photographer Lutz as always walked around tirelessly camera in hand to bring you this issue.
So enjoy.
Till Next Time, Ride Safe!
Mark & Pam


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Aiming High
Updated: December 15, 2008, 3:33 PM ETBy Kyle Carter | ESPNOutdoors.com
JONESBORO, Ark. The duck hunting wasn't quite as good as it was last year, but the NEA Clinic raised as much or more money in the sixth annual NEA Clinic Charitable Foundation Duck Classic.
"We were a little bit worried coming into this year, with the economy the way it is," said Holly Acebo, NEA Charitable Foundation executive director. "But everyone came out in full force. The sponsors, the volunteers and duck hunters were all great."
The process has been refined since ...
Read full story
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This post continues with the theme of how to modify plots from within ggplot; today we will specifically looking at custom axis breaks. Plots later in the week will examine the commands to change text in the plot area. The various other shortcomings of this plot will be discussed in future posts.
To create custom breaks on the Y-axis:


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Alabama Shakes' Brittany Howard Releases a Surprise Side Project
Still reeling from Sound & Colour? Alabama Shakes frontwoman Brittany Howard has dropped the fruits of her labor with a new-ish team of players from bands like Fly Golden Eagle and Clear Plastic Masks, called Thunderbitch. As you can see from the promo video, in which figures in white face paint, wigs and all-black… »


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Siddhartha's Intent / On Demand pages
Siddhartha's Intent has not created any On Demand pages yet. Browse On Demand work we love.
Browse VOD PagesVOD
Vimeo On Demand pages enable creators to sell their work to fans at the price they want. And it's a way for viewers to directly support creators whose work they enjoy. Everyone wins!


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UAE: Biggest climber in visa index
Click here for the top 10 rankings in the regionOctober 8, 2015 6:09
Register for our free newsletter
MIDEAST STOCKS-Markets to rise on stronger global environment
Abu Dhabi's ADWEA in talks with banks for $350 mln project bond
Emirates hints at no Dubai Airshow orders, pushes decision on A350/787 to next year
UAE minister says plans to boost oil output capacity on track
MIDEAST STOCKS-Saudi, Egypt markets barely move in early trade
Qatar Q2 GDP growth accelerates to 4.8 pct year/year
UAE says reforms will better protect foreign workers
United Arab Bank secures $125 mln three-year loan
MIDEAST STOCKS-Saudi hit by weak oil, commodities; Egypt down modestly
MIDEAST STOCKS-UAE markets narrowly mixed in thin, early trade
Saatchi's outspoken CEO Kevin Roberts tells Austyn Allison from Communicate that the time for analysis is over. Advertising is going to get ugly.
July 22, 2009 8:01 by Austyn Allison
Are you going to be opening Saatchi S [the division of the agency that deals with sustainability] here?
I think first we're going to open Saatchi and Saatchi X [the agency's shopper marketing arm] in a big way, because I think there's an enormous potential for us to get involved at point of sale. If you look at the supermarkets around here, it's still below-the-line. It's still sales promotions, that classic thing. With Saatchi X, we work for Wal-Mart, we work for Carrefour, we work for P&G in Wal-Mart, and we work for Frito Lay in the US.
The whole focus now of Saatchi X is not to turn shoppers into buyers, which is what it used to be, but to improve the life of shoppers in the store. So, how do you do that? That is a real challenge, given the retail environment. Saatchi X will be the first priority [and should be arriving imminently this year]. Then I think sustainability will probably be something we look at in 2010 and 2011.
Have you switched those expansion plans since last year?
Yeah, because the spending from clients has moved from the long term to the short term and moved from strategy to execution, and budgets have switched really to below-the-line and in-store. So we think there's an awesome opportunity now to build in-store capability. Not the old-school below-the-line promotion, but through Saatchi & Saatchi X.
Do you think above-the-line is on the way out?
There will be no line. There will be big ideas companies. It will be those people that come up with revelations. We live in the age of the idea. There will be creative shops. Hence my wake-up call to the Middle East, that if you don't get creative here, you won't exist. Because ideas, not processes, not functionality, not systems, are driving consumer choice in this new age.
First seen in Communicate magazine.
1 Comment
I'm looking for an agent to promote my books
Al Fahim named Pompey chairman
July 21 2009
UN asks Arab World to get its act together
July 22 2009


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Sailing on Melbourne's Albert Park Lake
.Learn to Sail .Year round Club Racing .Social Sailing
Albert Sailing club sails on Albert Park Lake, bayside less than 5 kilometres south of the Melbourne CBD.
The club always welcomes new members sailing their own monohull dinghy class boat or people wanting to join and learn to sail in a club dinghy sail boat. We have a range of membership options for adults, youth, juniors and families. Join The Club
Whether you are new to sailing and looking to learn to sail or a more experienced sailor seeking to improve your skills, Albert Park lake is one of the world's most convenient and challenging sailing venues.
Undercover boat storage provides convenience and easy access to rigging areas and the Lake. The clubhouse is located on Aquatic Drive, at the northern end of the lake behind Lakeside stadium. Low cost all day parking is available on weekends and hourly rate weekday parking behind the clubhouse.
To learn more about the club you can start with this site, and follow-up with a telephone call to the club or a visit on a club sailing day, including most Saturdays of the year.
The Albert Sailing Club is open:
Saturdays: Saturday mornings from 10am and afternoons, except long weekends and Christmas break
Sundays: Club open for monthly Sunday social sailing days and special events.
Twilights: Tuesdays or Wednesdays during late Spring and summer months.
See weekly Thursday Snippets in the side bar for information on current activities.
Spring Sailing Season on Saturdays to mid December Club open from 10am. Information session for fleet races 1.15 for 2.30pm starts.
Next Learn to Sail program is on Saturday mornings from 10 October. Other programs according to need. Training
Sunday Social Sailing Days End of each month. General public most welcome.
Discover Sailing Public Open Day 8 November from 10am to 3pm. Discover Sailing Open Day
Email : email@example.com
Tel : (03) 9690 2374
Spring 2015 Mudpuddler Newsletter under "News" tab on "The Club"


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ADG is bringing Open Turntables to Brooklyn!
Every first and third Sunday of the month, ADG will host Open Turntables, from 4pm-closing at LP & Harmony in Williamsburg, BK. This is an amazing venue that is really supportive of the NYC music and DJ scene with a great booth, an outdoor patio and some amazing vibes!
If you would like to spin, sign up to attend an event, answer the questions below and we will do everything we can to slot you in the line up! You must have attended at least one event without spinning to be able to spin.
The DJ booth has
-2 Technic 1200s
-2 Pioneer CDJ1000s (they DO NOT read MP3 CDs)
-Serato SL1 Box
-UREI Rotary Mixer.
We will be bringing our own mixer (non-rotary) but otherwise YOU must bring your own needles, slip mats, control vinyl, transition vinyl, etc. Non-Serato users are of course welcome as well but you must specify your setup in the questions below.
Drink Deals:
$4 Well Drinks (except tequila and brandy) until 8pm ($5 after)
$3 PBR Tall Boys – all night
$5 Guiness – until 8p.m. ($6.00 after)
$6 PBR tall boys with well shot
$5 Sangria
Looking forward to seeing you on the dance floor!
Good vibes...
0 · November 18, 2013
Its like hanging out with family with great music in the background! it was fantastic!! Nothing less than a good time!!
1 · November 18, 2013
Amazing night. Everyone was so chill and just down to have good time with good music! Perfect vibe!
1 · November 18, 2013
Meetup has allowed me to meet people I wouldn't have met naturally - they're totally different than me.
— Allison, started Women's Adventure Travel
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


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merafe resources ltd (MRF:Johannesburg)
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1783 1C Washington Unity States Cent -- Bent -- NGC Details. VF. NGC Census: (1/132). PCGS Population (10/280). (#689.58)...Click the image to load the highest resolution version.
Description1783 1C Washington Unity States Cent -- Bent -- NGC Details. VF. NGC Census: (1/132). PCGS Population (10/280). (#689.58) (NGC ID# 26AM, PCGS# 689)
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Have you had enough? Is there a candidate that you just WILL NOT vote for?
This is your opportunity to be heard and maybe win a Blaze Prize Pack!
Choose any announced candidate for President in 2016 and produce a video exclaiming "#NotThatGuy"
Videos must not be longer than 30 seconds and must somewhere contain "#NotThatGuy"
To officially enter your video post it to YouTube and share the link by tweeting it with #NotThatGuy.
The finalists will be announced 11/1/15 (exactly 1 year before election day 2016.)
The winner will be chosen by on-line voting a couple weeks later.
In the coming weeks we'll share some videos RIGHT HERE!
Categories: VIDEOS


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Klopp confirmed as Liverpool manager
Jurgen Klopp is appointed Liverpool's new manager, with the former Borussia Dortmund boss signing a three-year deal worth £15m.BBC Sport » 8h
Jurgen Klopp is appointed Liverpool's new manager, with the former Borussia Dortmund boss signing a three-year deal worth £15m.BBC Sport » 8h
Shane Long came off the bench to fire the Republic of Ireland to a historic victory over the world champions and guarantee Martin O'Neill's team a place in the Euro 2016 play-offs at least. But why should they settle for that now they have shown they are capable of victories like this? On SundaGuardian » 10h
Shane Long came off the bench to score the winner for the Republic of Ireland as they beat the world champions for the first time and kept alive their hopes of qualifying for Euro 2016 with a famous victory Match report: Republic of Ireland 1-0 Germany 10.10pm BST And finally, here's Paul Doyle�Guardian » 10h
Liverpool have confirmed the appointment of former Borussia Dortmund coach Jurgen Klopp as their new manager.EatSleepSport » 10h
Just how good is Liverpool's new manager? Watch the video to find outThe Independent » 14h
LIVERPOOL'S Emre Can insists he made the right decision to leave the Bundesliga for the Premier League.Daily Express » 14h
The former Borussia Dortmund manager has agreed a three-year deal at Anfield with an option for a fourthThe Independent » 15h
Jürgen Klopp has agreed to Liverpool's terms to become the next Liverpool manager following Brendan Rodgers departure. Here we take a closer look at Klopp's record at Borussia Dortmund by numbers. Klopp is due to sign a three year contract with the space to extend this further. The 48-year-oldGuardian » 15h
Select the table based on the criteria you select, which can include venue, goals scored and conceded and the total goals in the game. The results are presented in our standard True Table format.
Our true tables show a team's playing record without any points adjustments and are based on average points per game.
This table is Sortable.
Click on a column heading to sort by that column, click again to sort in reverse order. Click on any column appearing in yellow to return the table to its original order.
The default sort order is usually best to worst or alphabetical. Hover over the headings to reveal which columns can be sorted.