text: No recent wiki edits to this page. Brief HistoryDominic was the only son of Cressida and Derek Desford. They were fascinated with mutations, and tried to mutate their son by transplanting genetic materials from birds into Dominic. He finally got wings when his father accelerated the process by using radiation. The downside of the experiments was that Derek died of cancer and Dominic got cancer as well. Cressida didn't tell Dominic about his disease. Angel learned about Dominic's disease from a letter by Cressida's doctors, and paid Dominic's medical bills since that day, and Cressida told Dominic that Angel was his father. The payments stopped when Angel was presumed dead.Dominic was sent to X-Factor's HQ by his mother, and after flying past their window he got their attention. Beast and Iceman followed Dominic right into Murderworld, but Dominic didn't want the men to get hurt, and watched them fight off Murderworld's weapon systems. When a laser aimed at Dominic, his mother deactivated it which angered Arcade, but Cressida was the paying customer, and so Arcade gave her the chance to tell her son over the loudspeaker to get back to the control room, but Dominic wanted to help Beast first. He found Beast, who told him to return to Iceman before he got squashed by the attacking tentacles. On his way back Dominic met his mother and this time he followed her order to return to the control room. From the control room he listened to the conversation between Cressida and the two heroes and Dominic pleaded over the loudspeaker to let the heroes go because they were friends of Angel, who Dominic still believed to be his father. Dominic returned into his mother's arms after the heroes were allowed to leave. When they were gone Cressida told Dominic to put his special jacket back on to hide his wings because nobody should find out that they were real.


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There are no Upcoming Shows listed for this artist.
Irvine, CA
Comedy Central Certified
Amir K
AMIR K is currently on the cast of the MTV prank show, JERKS WITH CAMERAS. Last year, Amir made his foray into film with roles in Ben Affleck's ARGO and Alexandre Aja's SITE (for Fox), where he stars as the love interest opposite Ashley Hinshaw. In addition to acting, Amir is an accomplished comedian who can often be seen headlining Los Angeles comedy venues such as The Comedy Store, Laugh Factory and The Improv. Born in Tehran, Iran and raised in Southern California, his comedy is a blend of character work, storytelling and improvisation shaped by a multi-cultural upbringing. Amir is fluent in Farsi, Spanish and is known for his incredible accents and impressions.
Amir K's Upcoming Events
Amir K's Videos
Upcoming Shows
- Thu 10.8.15 - 10.10.15 JIM NORTON Buy Tickets
- Sun 10.11.15 - 7:00 PM ARSENIO HALL Buy Tickets
- Tue 10.13.15 - 8:00 PM COMEDYJUICE W/ NIKKI GLAZER, JODI MILLER AND MIKE MALONE Buy Tickets
- Wed 10.14.15 - 8:00 PM JAKE HURWITZ and AMIR BLUMENFELD - "IF I WERE YOU" LIVE PODCAST Buy Tickets
- Thu 10.15.15 - 8:00 PM K-VON Buy Tickets
- Fri 10.16.15 - 10.17.15 BILLY GARDELL Buy Tickets
See All Shows

subset: commoncrawl


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DPS Principal
Commitment for Complete Growth and Education
Thank you very much for the interest you have evinced in Delhi Public School Bhagalpur – a center for learning and excellence in eastern part of the country. This is the third session in the history of school starting April 2006. We are indeed honored to share with you our perception of Education.
Happiness in student does not consist merely in laughing, shouting, clapping hands and running here and there. Happiness of student is first of all relaxation, liberation from tension of all sorts, an expansion of the being in silence and peace in character, resulting into complete education. Hereafter comes a mite joy, a smile, the effluence of a sweet presence within, a look of friendliness towards the world that he or she has to live in. Our teachers here know and feel the requirements of every student, be it physical, emotional, psychological, intellectual and even the psychic needs pertaining to the soul in evolution. Fundamentally, the child is growing being, growth in his raison d'etre.
Education is not a one day event, nor of months and neither of years, but a lifetime opportunity. All of us learn every day and there always remains something unknown for the next day in store for us. Process of Education in DPS Bhagalpur carries with itself an attitude of understanding, of love, of expectation, of patience, of acceptance of childhood, of happiness, delicately acknowledgement and according value to the Time as important period in Nation and Humanity Development. We believe in giving a conducive atmosphere to every child for her/his complete growth. For us the first task of the teacher is to keep the school environment adequately supplied with ingredients of education; the second task is to be constantly present – steady and unwavering; the third being establishing of hundred percent discipline with two hundred percent affection. The school always remembers that for a child every action is an experiment and a step towards making of a great nation – India. We are confident that our students will grow to become successful "Global Citizens".
Dr. Arunima Chakravorty
Email - firstname.lastname@example.com


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The Pro Squash Tour posted this full match replay of the final of the 2013 Cleveland Classic, between David Palmer and Thierry Lincou. The first game is pretty error-filled, but the rest of the match … [Read more...]
PST Cleveland Classic Squash Tournament
Photo via PST Thierry Lincou, recently relocated to the US and playing in his first Pro Squash Tour event, beat Wael El Hindi in 5 games to win the Cleveland Classic. Looks like Thierry (left) has … [Read more...]
Thierry Lincou Squash Videos
Thierry Lincou just announced his retirement from the PSA World Tour. The Frenchman was a former PSA World #1, and World Open champ in 2004. That salt and pepper hair. Those knee-high socks. That … [Read more...]


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Brendan Perlini's goal with 6:37 remaining in regulation was the game-winner as Canada beat Slovakia 2-1 Sunday in a preliminary-round game at the 2014 IIHF World Under-18 Championship at Imatra Arena in Imatra, Finland.
Perlini, No. 8 among North American skaters in Central Scouting's final rankings for the 2014 NHL Draft, scored two goals after Slovakia took a 1-0 lead after one period.
Mason McDonald, ranked No. 2 by Central Scouting among North American goaltenders, stopped 21 of 22 shots, and Canada improved to 3-0 in the tournament and remained alone atop Group A.


text: Mashup: Florida Real Estate Comments Share via FacebookShare via TwitterShare via LinkedinShare via Google+Share via RedditShare via Mail BLUE ONE Realty real estate. Search homes in Florida. Search homes, condos, townhouses, and commercial properties by MLS or by city. Track this Mashup Submit a mashup Summary Comments Followers Summary Comments Followers Comments (1) Comments(1) Comment * Leave this field blank Post Comment brian 7:26 AM Jan. 12 2008 reply Really enjoyed this mashup :) Good fast advanced search all over the US. Found something interesting :)


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Lessons from a FinTech CEO
For some people, fear and money go hand in hand
Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more!
's latest ad campaign pits its Surface Pro 3 against
's Macbook Air. Emphasizing its superior specs, utility, and
customization, Microsoft appears bent on selling its latest
laptop/tablet hybrid to would-be buyers of Apple's Ultrabook.
Although the Surface Pro 3 comes out ahead in several key
areas, it doesn't seem likely to unseat Apple's Macbook Air.
Jack of all trades, master of none
Microsoft's most recent ad, titled "Power," emphasizes the
Surface Pro 3's unique capabilities. Unlike Apple's Macbook Air,
Microsoft's Surface Pro 3 includes a touch screen, a stylus, and
a kickstand -- it is, as Microsoft repeatedly emphasizes, the
"tablet that can replace your laptop."
Although the Surface Pro 3 is a dramatic improvement over its
predecessors, major reviews have found fault with the device,
particularly in the context in which Microsoft has chosen to
present it. Compared to other laptop/tablet hybrid, the Surface
Pro 3 is unmatched, but when compared to Apple's Macbook Air, it
comes up lacking.
's Katherine Boehret, in particular, took issue with the
comparison, declaring bluntly that the Surface Pro 3 didn't stand
up to the Macbook Air. As a tablet, the Surface Pro 3's size is a
hinderance -- and as a laptop, it's makeshift keyboard is a
severe limitation.
Microsoft's money-losing Surface
From a business perspective, it's become difficult to tell what
Microsoft hopes to accomplish with the Surface -- it hasn't made
the company money, and seems only to have weakened the Windows
Microsoft may wish to brand the Surface Pro 3 an alternative
to Apple's Macbook Air, but in reality, it could be far more
threatening to other Windows-powered Ulrabooks. Responding to
Microsoft's recent shift into hardware,
's CEO branded Microsoft an outright competitor; Acer has made
similar remarks in the past.
At its best, the Surface Pro 3 appears to perfectly embody the
spirit of Windows 8 -- one device for an operating system that
can do just about anything. But if recent reports prove true,
Microsoft may be moving away from such a strategy: Windows 9, due
out next year, is rumored to reverse many of the changes
Microsoft made to Windows, including bringing back the start
button, doing away with the charms bar, and removing the Metro
interface from Windows-powered desktops.
It's difficult to tell exactly how much Microsoft has lost on
its Surface venture, but
recently estimated that it may be as much as $1.7 billion. To be
fair, that's not much to a company with $85 billion in the bank,
but it's certainly not a positive.
Mac market share is steadily increasing
"Our competition...is confused," Apple's CEO Tim Cook said last
year in an obvious reference to Microsoft's Surface. "They're
trying to make PCs into tablets and tablets into PCs."
As Microsoft struggles to find a market for its Surface,
Apple's Macbooks have only become more popular. Mac market share
has steadily risen over the last decade, and its growth in the
U.S. has picked up in recent quarters.
Apple's Macs now consistently account for more than 10% of the
U.S. PC market, and at times has defied the general slump in PC
sales -- last holiday quarter, for example, Apple's Macs outpaced
the larger PC market by around 36 percentage points, according to
research firm Gartner.
The Macbook Air, in particular, appears to have been
instrumental in the Mac's recent resurgence. Apple's share of the
U.S. PC market broke above 10% for the first time in recent
history in the third quarter of 2010, just a year and a half
after the first-generation Macbook Air debuted. More recently,
research firm NPD reported that the Macbook Air accounted for 56%
of the Ultrabooks sold in the U.S. during the first five months
of 2013.
Unfortunately for Microsoft, the Surface Pro 3 does not appear
to be the device to reverse that trend. Perhaps consumers will be
swayed by this recent advertising blitz, but if history is any
guide -- Microsoft allegedly spent more than $1 billion
advertising Windows 8 and the original Surface in 2012 -- that
seems unlikely.
Leaked: Apple's next smart device (warning, it may
shock you)
Apple recently recruited a secret-development "dream team" to
guarantee its newest smart device was kept hidden from the
public for as long as possible. But the secret is out, and some
early viewers are claiming its everyday impact could trump the
iPod, iPhone,
the iPad. In fact, ABI Research predicts 485 million
of this type of device will be sold per year. But one small
company makes Apple's gadget possible. And its stock
price has nearly unlimited room to run for early in-the-know
investors. To be one of them, and see Apple's newest smart
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click here
The article
Microsoft Surface Pro 3 Takes Aim at the Macbook
Air -- Again
originally appeared on Fool.com.
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reserved. The Motley Fool has a
disclosure policy
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MICHAEL Michael Kors' gold-studded tote will add tough-luxe appeal to every look. The midnight-blue textured-leather is a cool alternative to black, and we love the handy shoulder strap. Store your valuables in the zip-fastening pocket.
Navy textured-leather (Cow)Two top handles, chain-trimmed shoulder strapStuds, functioning padlock and key, gold hardware, feetInternal pouch and zip-fastening pocketsFully lined in champagne designer-stamped canvasMagnetic snap fastening at topComes with dust bag
Product code: 341861 - Need help? Contact us


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Home Page Potential Lawsuit Toyota Accelerator Pedals
Toyota Recall
Were you looking for Car Accidents (National) lawsuits?
In January, 2010, consumers learned about a Toyota safety recall that affects approximately 2.3 million vehicles. The Toyota recall is reportedly due to an issue in which accelerator pedals on specific Toyota models become stuck.
Toyota also recalled approximately 4.2 million Toyota and Lexus vehicles due to the risk of pedal entrapment from incorrect or out-of-place accessory floor mats. Although the two Toyota safety recalls are separate, approximately 1.7 million Toyota vehicles are subject to both recalls .
Toyota Accelerator Pedal RecallApproximately 2.3 million Toyota vehicles have been recalled due to sticking accelerator pedals. Toyota has also said that it was halting sales of the vehicles included in the recall.
Those vehicles are:
No Lexus Division or Scion vehicles are affected by this recall action. Also not affected are Toyota Prius, Tacoma, Sienna, Venza, Solara, Yaris, 4Runner, FJ Cruiser, Land Cruiser and select Camry models, including all Camry hybrids.
Toyota Floor MatOn September 29, Toyota issued a news release asking owners of specific Toyota and Lexus models to take out any removable driver's floor mat and NOT replace it with any other floor mat. On January 27, 2010, Toyota sent a letter to the National Highway Traffic Safety Administration amending Toyota's Defect Information Report of October 5, 2009, regarding the potential risk for floor mat entrapment by accelerator pedals in certain Toyota and Lexus models. Toyota has now decided to include certain other models in the recall. This action is separate from the recall of select Toyota vehicles for sticking accelerator pedals.
The specific model names and years of vehicles recalled due to floor mat pedal entrapment:
Toyota Accidents and InjuriesAccording to the Los Angeles Times (11/29/09) at least 19 deaths were attributed sudden acceleration in Toyota vehicles since the start of the 2002 model year. During the same time, all other automakers had a combined total of 11 deaths related to sudden acceleration.
The August 28, 2009, death of a California Highway Patrol officer and his family was initially blamed on floor mat entrapment. However, safety experts and motorist accounts point to issues with electronic throttles.
Meanwhile, other Toyota drivers say they pleaded with the company to fix the problem. One Toyota owner appeared on Good Morning America saying her car suddenly accelerated three times. The problem was never fixed and four people died when the car was in an accident.
Furthermore, according to the Times, at least 1,000 incidents of sudden, unintended acceleration were reported to the National Highway Traffic Safety Administration in the past eight years.
Toyota LawsuitsLawsuits have now been filed against Toyota, alleging the company knew about the issue with the accelerator but did not warn the public or regulatory agencies. At least one lawsuit alleges Toyota intentionally made false statements to sell vehicles and committed fraudulent concealment by not informing consumers about defects in the vehicles.
Last updated on Apr-21-10
Toyota Recalls 400,000 for Steering Defect
New York, NY: After a federal grand jury subpoenaed documents relating to how Toyota handled steering problems in some of its older vehicles, the carmaker formally recalled some 400,000 vehicles in the US for potential steering problems. The recall involves a mechanism that could fail in certain conditions, increasing the likelihood of a crash [READ MORE]
Toyota Again Under Fire, Subpoenaed by US Federal Grand Jury
Tokyo, JAPAN: After a brief respite from the public spotlight, Toyota is again under scrutiny after being served with a subpoena from a federal grand jury in New York seeking information on steering-related problems. The subpoena may also trigger a wider investigation into a 2005 Toyota recall that brings to mind the recent debacle over rapid acceleration [READ MORE]
Toyota Accelerator Recall Repairs by the Numbers
Detroit, MI: As the lawsuits continue to pile up and the Toyota continues to deny that rapid acceleration has anything to do with electronic throttle systems, the automaker has been quietly repairing the millions of vehicles recalled for sticking accelerator pedals, ill-fitting floor mats and software updates for specific models. Today's issue of just-auto global news reports that Toyota has serviced just over three million vehicles for various recall deficiencies in the US [READ MORE]
READ MORE [ Automotive Settlements and Legal News ]
READ MORE [ Defective Products Settlements and Legal News ]
READ MORE [ Personal Injury Settlements and Legal News ]
Posted by
Misha Pettway
On Monday September 28 about 10:30am I was on my way to the gas station, turned off the main street onto a side street as I approached a stop signed I pressed the brake pedal and my 2000 Toyota Sienna wouldn't stop. Thank God I was on the phone with an experienced driver who told me to put on my emergency brake but that didn't stop the van. She then suggested that I throw the van into park and when I did the van stopped. I am so grateful I didn't hit anybody or thing.
Posted by
In February 2008, while driving on Interstate 80 at posted speed limit with speed control in use, my 1994 Toyota small pick-up truck started going faster and did not respond to brakes causing me to be in a roll over accident and my truck to be totaled out by my insurance company. My injuries were minimum thank God and I did not require medical attention.
Posted by
The brakes on my 07 Highlander Hybrid failed causing a 3 car accident with no injuries. I traded it in because it was unsafe and the Toyota dealership gave me a terrible deal. I have tried to work with Toyota's corporate customer service but the case manager is truly terrible, rude, and doing everything she can to blame this on me and they are not helping at all.
Posted by
I have a 2010 toyoto corolla I bought it in august 2009 it is the worst money I ever spent . I have had it to the dealer about 12 times with problems . The car will just stop running and will take 45 minutes to an hour before I can gey it to start again . This happens two or three times a week if any body out there has such problems please contact me . Thank you.
Posted by
I have 1999 Toyota Sienna that my wife and i both encountered the same problem. Once we press the gas pedal, it was stuck and wouldn't come back, you need to repeatly press couple of times so it then can be released. We thought it is the structure defect, has more metal contact so it is not easy to return.
Now we are a little bit scared if the Sienna has the same behavior like other recalled cars, what are we going to do?
Besides, the sliding door handles are too easy to broke. We changed the handle, and it still gives us the feeling "will be broke" again.
Posted by
Before I could stop my runaway car, I struck a parked car and damaged my car. Total repair cost $1,580.
Toyota's response to my letters refuses to acknowledge any responsibility. I was afraid to drive the car and though it was only a year old, I traded it in at a further cost of $5,800.
Posted by
I am afraid to drive the car, worried when I do, and cannot sell it because it has lost value due to defective parts (4 recalls so far).
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State Law Changes To CHRO
As I've noted before, the CHRO procedures were changed effective October 1, 2011. One question that we had at the time was whether the CHRO would be retaining more discrimination claims by employees for investigation — getting past the Merit Assessment Review stage.
Previously, employers have had at least a little luck getting plainly frivolous claims thrown out at MAR.
If the reports I've been getting from multiple reliance sources are true, then it appears those days are over.
I've spoken with several people this month about cases that they are seeing at the CHRO. Universally, the reports are that the CHRO is retaining nearly every case for a fact-finding and mandatory mediation, even the blatantly frivolous ones....
Please see full article below for more information.
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Mark A. Smith is professor of Political Science and an adjunct professor of Comparative Religion and Communication at the University of Washington. His research focuses on economic and religious groups, ideas, and influences in American politics. In his new book, Secular Faith: How Culture Has Trumped Religion in American Politics, Dr. Smith argues that religion is not nearly the unchanging conservative influence in American politics that we have come to think it is and is best understood as responding to changing political and cultural values rather than shaping them.
Pro-Choice and Pro-Life? On Abortion, Americans Say "It's Complicated"
Can terms like "pro-choice" and "pro-life" adequately capture the complexity of Americans' views on abortion? In this week's post for "Figuring Faith," Dr. Robert P. Jones tackles this tough question, responding to recent data from Gallup which appears to show a sharp drop in the number of Americans who identify as "pro-choice." Dr. Jones uses findings from a PRRI survey to show why this conclusion is more reflective of the shifting winds of rhetoric than Americans' perspectives on abortion's legality:
Last summer, a major national survey by Public Religion Research Institute uncovered a surprising but critical feature of the abortion debate: 7-in-10 Americans reported that the term "pro-choice" described them somewhat well (32 percent) or very well (38 percent), and nearly two-thirds simultaneously said that the term "pro-life" described them somewhat well (31 percent) or very well (35 percent). In other words: when they were not forced to choose between one label and the other, over 4-in-10 (43 percent) Americans said that they were both "pro-choice" and "pro-life."
To read the full column, head over to "Figuring Faith," Dr. Jones' blog at the Washington Post.


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Author Archives for: jenn s.
JENNIFER SBRANTI is the co-founder and Editor-in-Chief of Hostess with the Mostess® (HWTM), a hip and modern party planning resource. HWTM brings creative entertaining ideas to light through an inspirational "how-to" website and popular daily blog.
Having hosted countless celebrations herself, ranging from special occasion showers and everyday get-togethers to large events, Sbranti now shares her contemporary style and no-fuss approach to entertaining with others. Her ideas have been featured in media outlets such as People, InStyle Weddings, Life&Style, Real Simple, and Extra! TV, and she is a featured contributor for several well-respected online communities, including iVillage.com and BHG.com.
Sbranti resides in San Diego with her husband {and business partner} Sonny and their sweet 1-year old daughter, Macy.Follow Me on Google+ Follow @hwtm_jenn
GroBal: Cultivate Style
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- Home Decor
- Hostess Gift Ideas
Good news for those of us with "not-exactly-green" thumbs! GroBal and GroBal Baby are stylish, ultra-modern planters with a unique watering system that does the work for you… just check the water filter indicator and refill when needed! Thanks to GroBal designer Karim Rashid, my houseplants might stand a chance at staying lush and green […]
Throw an Eco-Chic Baby Shower
- posted in:
- Baby Showers
- Inspiration Boards
Looking for earth-friendly ideas for welcoming baby-to-be in style? Check out my Eco-Chic Baby Shower article over at TheCradle.com for some inspiration… And if you have any favorite "green" products or ideas of your own that would be great for baby showers as well, feel free to share them here!
Spring Party Ideas
- posted in:
- Bridal Showers
- Centerpieces & Decor
If you're hosting a party or shower this spring, the Spring Parties Ideas gallery on marthastewart.com is full of inspiration! I especially love the idea of the butterflies on the paper lanterns (pictured above), and would love to try a super contemporary approach to this idea: maybe all-white butterflies on vividly colored lanterns like fuschia, […]
Ren Noodle Bowls & Tea Set
- posted in:
- Fabulous Finds
This contemporary Ren Noodle Bowl & Chopstick Set is made especially for serving Asian noodles and already has me craving Pad Thai at 9 in the morning! ($29.95/set of 2) I'm also loving charming, zen-like quality of the coordinating Ren Teapot and Cups Set. ($39.95)
Bamboo Brights
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- Fabulous Finds
When I hear the words "eco-friendly" used to describe a product, visions of natural, earthy tones are usually what come to mind – which is why these vibrant, colorful, and sustainable bamboo serveware products from Delight.com are a breath of fresh air! Trio of Colorful Sustainable Bamboo Nesting Bowls (in azure, tangerine, and watermelon) – […]
Colin Cowie Chic
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- Fabulous Finds
- Party Books
For the past couple weeks, I've been trying to peel myself away from the computer long enough to spend some quality time with the latest book by lifestyle & entertaining extraordinaire Colin Cowie , aptly named: Colin Cowie Chic: The Guide to Life As It Should Be . The problem is – with everything going […]


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Excellent location, in an old monastery. Serene atmosphere.
The warm wind is omnipresent and makes this place unique. Situated on top of a cliff 200m above sea level is a guarantee for en excellent view over the harbour, the city and the inland mountains.
Strolling through the gardens of the Parador is already worth the visit. The only drawback: breakfast, not much choice and not a good value for money, you can however order breakfast in your room at no extra cost.
The menu in the restaurant is OK but if you only like 2 things on the menu you'll only go there twice as the menu did not change during our stay. Excellent choice of local wines!
No one forbids you to buy local food and have a cheese, bread and red wine dinner outside your hotel room in the unique atmosphere that makes La Gomera so special.
We used the hotel as our base while discovering the island with a rented car.
Hotel staff is very discrete and very helpfull.
We'd go there again for sure.


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- In our continuing effort to improve LIS services, all scheduled maintenance will be added below as notices are received
- Please bookmark this site for IT ALERTS
- For up to the minute IT and Critical IT Alerts follow us @WheatonSupport on Twitter or visit our website
- Most scheduled maintenance, especially Banner maintenance, will be performed during our normal Thursday evening maintenance window
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Alerts will be added as they are received... Please check this site on a regular basis.
IT SERVICE FYI: Address change for insideWheaton
Who: Wheaton College Faculty, Staff, and Students
What: Reminder, insideWheaton address has changed
Why: People still using old insideWheaton web address
When: Thursday 10/8/15 at 4:30 pm E.S.T.
Details: This past summer the address for accessing insideWheaton changed. The new address is https://portal.wheatonma.edu. If you have bookmarks pointing to the old address (https://inside.wheatonma.edu) it will no longer work starting Thursday 10/8/15 at 4:30 pm. Please update any bookmarks you might have that point to the old web address. If you have any questions or concerns regarding this message, please contact the LIS Technology Support Staff at 508.286.3900 <firstname.lastname@example.com>
IT SERVICE FYI: October is Cyber Security Month
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Page 1
Host Response to Translocated Microbial Products Predicts
Outcomes of Patients with HBV or HCV infection
Netanya G. Sandler1, Christopher Koh2,*, Annelys Roque1,*, Jason L. Eccleston2, Rebecca
B. Siegel1, Mary DeMino2, David E. Kleiner3, Steven G. Deeks4, T. Jake Liang2, Theo
Heller2, and Daniel C. Douek1
1Human Immunology Section, Vaccine Research Center, National Institute of Allergy and
Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892
2Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH,
Bethesda, MD 20892
3Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD 20892
4HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of
California, San Francisco, CA, USA
Background & Aims—Chronic infection with hepatitis B or C virus (HBV or HCV) is a
leading cause of cirrhosis, by unknown mechanisms of pathogenesis. Translocation of gut
microbial products into the systemic circulation might increase because of increased intestinal
permeability, bacterial overgrowth, or impaired clearance of microbial products by Kupffer cells.
We investigated whether the extent and progression of liver disease in patients with chronic HBV
or HCV infection are associated with microbial translocation and subsequent activation of
© 2011 The American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.
Corresponding authors: Dr. Daniel C. Douek, National Institutes of Health, Vaccine Research Center, 40 Convent Drive Room 3509,
Bethesda, MD 20892, Phone: 301-594-8484, Fax: 301-480-2565, email@example.com, Dr. Theo Heller, National Institutes of
Health, Building 10 - Magnuson Clinical Center, 10 Center Drive Room 9C432B, Bethesda, MD 20892, Phone: 301-402-7147, Fax:
301-402-0491, email@example.com.
*These authors contributed equally to this work.
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Author contributions:
NGS: study concept and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; critical revision of
the manuscript for important intellectual content; statistical analysis
CK: study concept and design; acquisition of data
AR: acquisition of data; analysis and interpretation of data; statistical analysis
JLE: acquisition of data
RBS: analysis and interpretation of data
MD: acquisition of data
DEK: acquisition of data; analysis and interpretation of data
SGD: acquisition of data; study supervision; obtained funding; critical revision of the manuscript for important intellectual content
TJL: acquisition of data; study supervision; obtained funding
TH: study concept and design; acquisition of data; study supervision; obtained funding; critical revision of the manuscript for
important intellectual content
DCD: study concept and design; obtained funding; drafting of the manuscript; critical revision of the manuscript for important
intellectual content
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Author Manuscript
Gastroenterology. Author manuscript; available in PMC 2012 October 1.
Published in final edited form as:
Gastroenterology. 2011 October ; 141(4): 1220–1230.e3. doi:10.1053/j.gastro.2011.06.063.
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Methods—In a retrospective study, we analyzed data from 16 patients with minimal fibrosis, 68
with cirrhosis, and 67 uninfected volunteers. We analyzed plasma levels of soluble CD14
(sCD14), intestinal fatty acid binding protein (I-FABP), and interleukin (IL)-6 by ELISA, and
lipopolysaccharide (LPS) by the limulus amebocyte lysate assay, at presentation and after antiviral
Results—Compared with uninfected individuals, HCV- and HBV-infected individuals had
higher plasma levels of LPS, I-FABP (indicating enterocyte death), sCD14 (produced upon LPS
activation of monocytes), and IL-6. Portal hypertension, indicated by low platelet counts, was
associated with enterocyte death (P=.045 at presentation, P<.0001 after therapy). Levels of sCD14
correlated with markers of hepatic inflammation (P=.02 for AST, P=.002 for ferritin) and fibrosis
(P<.0001 for gamma-glutamyl transpeptidase, P=.01 for alkaline phosphatase, P<.0001 for alpha-
fetoprotein). Compared to subjects with minimal fibrosis, subjects with severe fibrosis at
presentation had higher plasma levels of sCD14 (P=.01) and more hepatic CD14+ cells (P=.0002);
each increased risk for disease progression (P=.0009 and P=.005, respectively).
Conclusions—LPS-induced local and systemic inflammation are associated with cirrhosis and
predict progression to end-stage liver disease in patients with HBV or HCV infection.
Microbial translocation; soluble CD14; hepatitis; intestinal fatty acid binding protein; chronic liver
disease; histology; immune response; microbiota
Approximately 350 million people worldwide live with chronic HBV infection1 and over
200 million with chronic HCV infection2. Twenty-five percent of patients with chronic HBV
infection die from chronic active hepatitis, cirrhosis or cancer. Twenty percent of patients
with HCV infection progress to cirrhosis, of whom 20–25% progress to liver failure and
death. The determinants of progression to cirrhosis and liver failure are poorly defined.
One contributor to chronic inflammation and fibrosis in chronic HBV and HCV infection is
microbial translocation. Immunostimulatory microbial products from the intestine, such as
lipopolysaccharide (LPS), translocate into the portal system where they are sensed and
cleared by Kupffer cells. In the setting of liver disease, however, bacterial overgrowth,
intestinal edema, altered hepatic architecture and Kupffer cell dysfunction increase entry of
LPS into the peripheral circulation3,4. Increased plasma LPS levels have been reported in
patients with chronic active hepatitis and cirrhosis due to viral hepatitis, alcohol and non-
alcoholic fatty liver disease5–9.
LPS binding protein binds LPS, facilitating its binding to membrane CD14 (mCD14) on
myeloid cells or to circulating soluble CD14 (sCD14)10. sCD14 transfers LPS to mCD14
and both sCD14 and mCD14 transfer LPS to the myeloid differentiation-2 (MD-2)/TLR4
complex, or to the MD-2/TLR4 complex11–14. The MD-2/TLR4/LPS complex activates NF-
κb, inducing inflammatory cytokine production15,16. LPS activation of myeloid cells causes
the shedding and secretion of sCD14, making sCD14 a marker of LPS bioactivity17–19.
While chronic liver disease may impair the clearance of translocating microbial products,
LPS may also contribute to liver injury. LPS injections augment liver damage caused by
carbon tetrachloride, choline deficiency and alcohol in animal models20. LPS mediates
Kupffer cell production of tumor necrosis factor (TNF), IL-6 and IL-18, neutrophil
recruitment, reactive oxygen species production and platelet aggregation in the hepatic
sinusoids, leading to hepatic necrosis3. Kupffer cells produce transforming growth factor β
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(TGFβ), activating hepatic stellate cells (HSCs) to synthesize extracellular matrix proteins,
resulting in fibrosis21,22. HSCs express TLR4, and LPS may activate HSCs by TLR4-
mediated downregulation of a TGFβ decoy receptor23,24. Thus, LPS may induce fibrosis
indirectly by inducing Kupffer cells to produce TGFβ and directly by sensitizing HSCs to
Because of the significant morbidity and mortality associated with progression to cirrhosis
and liver failure and the potential association of LPS with liver pathology, we sought to
investigate the relationship of microbial translocation and its downstream effects with
clinical outcome in chronic HBV and HCV infections. Thus, we evaluated enterocyte death,
microbial translocation, monocyte activation, liver function and liver pathology in a cohort
of adults chronically infected with HBV or HCV.
Study population
Eighty-four subjects with chronic HBV or HCV infection and 67 uninfected volunteers were
included (Table 1). Chronic HBV infection is defined by HBsAg positivity for >6 months,
serum HBV DNA >20,000 IU/ml, persistent or intermittent elevation in ALT or AST levels,
and liver biopsy showing chronic hepatitis with moderate or severe necroinflammation25.
Chronic HCV infection is defined as persistence of HCV RNA in serum 6 months after
infection26. The median age for all subjects was 49.9 years, and 30 subjects (36%) were
female. There were no significant associations between age or sex and any markers. Twenty-
one had chronic HBV infection and 63 had chronic HCV infection, 40 (63.5%) with
genotype 1. None of the subjects had underlying intestinal disease. Subjects were selected to
compare subjects with severe fibrosis to those without fibrosis. Ishak scores were 0 or 1 in
16 subjects and 5 or 6 in 68 subjects27. Eighty-three subjects were classified as Child's Class
A, and the median MELD score was 8. Thus, even subjects with severe fibrosis and cirrhosis
by liver biopsy were compensated cirrhotics. Baseline samples were drawn prior to antiviral
treatment. Follow-up samples were drawn at least 7 months after enrollment when possible.
Eight subjects were lost to follow-up.
Plasma sCD14 levels distinguish subjects with severe liver fibrosis from those with
minimal fibrosis
To assess for enterocyte loss, microbial translocation and the subsequent host response to
microbial products, we measured baseline levels of LPS, sCD14, IL-6 and intestinal fatty
acid binding protein (I-FABP), made exclusively by enterocytes and released into the
bloodstream upon enterocyte necrosis28–30, and compared values between subjects with
severe fibrosis and without fibrosis. sCD14 levels, reflective of LPS-induced monocyte
activation, were significantly higher in subjects with severe fibrosis (2.06 × 106 pg/ml;
Figure 1) compared to those without fibrosis (1.74 × 106 pg/ml, P=0.01) and healthy
volunteers (1.66 × 106 pg/ml, P<0.0001), but there was no significant difference between
subjects without fibrosis and healthy volunteers. I-FABP, LPS and IL-6, which may
facilitate hepatic healing and increase upon LPS-induced monocyte activation31,32, were
elevated regardless of fibrosis.
To further explore the relationship between LPS-induced monocyte activation and liver
pathology, we compared sCD14 levels to markers of hepatic inflammation, fibrosis and
synthetic function. sCD14 correlated with markers of hepatic inflammation, including AST
and ferritin (Figure 2A-B) and the histology activity index (HAI; r=0.27, P=0.01); hepatic
fibrosis, including gamma glutamyl-transpeptidase (GGT), alkaline phosphastase (ALP;
Figure 2C-D), and the AST to platelet ratio index (APRI) (Supplementary Table 1); and
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hepatic regeneration, specifically AFP (Figure 2E). Direct bilirubin also correlated with
sCD14, although the limited dynamic range of the direct bilirubin complicates this analysis
(Figure 2F).
To evaluate whether elevations of these markers were different in the two viral infections,
we compared values between the HBV- and HCV-infected subjects. sCD14 levels were
increased in subjects with either HBV or HCV infection, but only statistically significant
with HCV (Supplementary Figure 1). I-FABP, LPS and IL-6 levels were also higher in
subjects with either HBV or HCV infection compared to healthy volunteers. Of note, sCD14
and IL-6 levels were significantly higher in subjects with HCV than those with HBV
infection. Thus, while markers of enterocyte necrosis, microbial translocation and monocyte
activation are increased in subjects with HBV or HCV infection, the degree of the host
response to LPS, as reflected by the level of sCD14, correlates with hepatic inflammation
and distinguishes subjects with severe fibrosis.
Enterocyte death is associated with portal hypertension
To further explore which processes are involved in enterocyte death, which may facilitate
microbial translocation, we correlated baseline I-FABP levels to markers of liver pathology.
High baseline I-FABP levels correlated with high Ishak scores (r=0.23, P=0.04) and low
baseline platelet counts, a consequence of portal hypertension (r=−0.22, P=0.045; Figure
3A). Furthermore, after antiviral treatment, almost all subjects with detectable I-FABP
levels had platelet counts lower than 150,000/µl (Figure 3B), suggesting that portal
hypertension is associated with increased enterocyte death.
I-FABP levels were correlated negatively with albumin at baseline (Figure 2C) and
positively with direct bilirubin (see Supplementary Table 1). At follow-up, I-FABP levels
were correlated with albumin, direct bilirubin and international normalized ratio (INR)
(Figure 2D-F), supporting a relationship between enterocyte death and decreased hepatic
function. I-FABP also correlated with AST, ALT and alpha-fetoprotein (AFP) and with the
AST to platelet ratio index (APRI; see Supplementary Table 2) at follow-up, suggesting a
tight relationship between continued hepatic inflammation and fibrosis, portal hypertension
and enterocyte death.
I-FABP and IL-6 decrease with successful treatment of HCV infection
All 21 patients infected with HBV infection and 60 of the 63 patients with HCV infection
were treated according to standard of care, while two were never treated and one dropped
out of the study. Twenty-seven HCV-infected subjects had a sustained virological response
(SVR), defined by undetectable HCV RNA in serum at 6 months after completing therapy.
All HBV-infected patients remained on therapy for the duration of their follow-up.
To assess the effect of antiviral treatment on these markers, levels pre- and post-treatment
were compared. High baseline sCD14 levels were associated with failure to respond to
therapy for HCV, reflecting the connection between fibrosis and therapeutic failure. The
median baseline sCD14 level of subjects with SVR was 1.81 × 106 pg/ml compared to 2.24
× 106 pg/ml in nonresponders (P=0.001). No other marker was associated with response to
I-FABP levels in subjects with HCV infection and SVR fell from 295.4 pg/ml at baseline to
undetectable at follow-up (P=0.01, Figure 4A) but did not change in non-responders (Figure
4C). IL-6 followed the same pattern (Figure 4B, 4D). In HBV-infected subjects I-FABP
levels fell from 30.6 pg/ml to undetectable (P=0.008, Figure 4E), but IL-6 did not change
significantly (Figure 4F). Levels of sCD14 and LPS did not change appreciably regardless
of treatment response.
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At follow-up, sCD14 levels were associated with direct bilirubin, INR, ALP, GGT, ALT,
AST, AFP, APRI, total IgM, IL-6 and I-FABP and inversely associated with albumin and
platelet counts (see Supplementary Table 2). IL-6 levels also correlated with LPS and
markers of hepatic inflammation, fibrosis and poor synthetic function (see Supplementary
Table 2). Together, these data suggest a persistent association between LPS bioactivity and
hepatic inflammation, fibrosis, decreased synthetic function and portal hypertension. Thus,
successful treatment of HBV and HCV infections may attenuate intestinal epithelial necrosis
but does not decrease LPS or LPS-induced monocyte activation.
Baseline levels of sCD14 are associated with worse clinical outcome
The 43 subjects who responded to treatment and whose liver disease was stable had "no
progression," while the 31 with worsening cirrhosis based on clinical presentation, imaging
or biochemical parameters, splenomegaly, portal hypertension, hepatic encephalopathy,
hepatocellular carcinoma or need for liver transplant had "progression." The remaining
individuals had not been followed for a sufficient length of time to be classified. Four of the
progressors had HBV infection, 26 were HCV-infected nonresponders with hepatic
decompensation, and 1 had untreated HCV infection and hepatocellular carcinoma.
To determine whether these markers were associated with clinical outcome, subjects without
progression were compared to progressors. Baseline plasma levels of IFABP, LPS, sCD14
and IL-6 were elevated in both progressors and non-progressors compared to uninfected
individuals (Figure 5). However, sCD14 was significantly higher in progressors than non-
progressors (2.14 × 106 pg/ml vs 1.81 × 106 pg/ml, P=0.003; Figure 5C). Furthermore, an
increase in sCD14 of 1.0 × 106 pg/ml was associated with an odds ratio (OR) of disease
progression of 3.7 (P=0.007) with no change after adjustment for Ishak score, AST, ALT,
GGT, CRP, MELD score, APRI or HAI. sCD14 levels at follow-up were higher in
progressors than non-progressors (2.37 vs 1.93 × 106 pg/ml, P=0.001). No other marker was
associated with clinical outcome. Thus, high plasma levels of sCD14 predict poor outcomes
in individuals with HBV or HCV infection independently of other markers of inflammation,
disease progression and fibrosis.
A high density of hepatic CD14+ cells is associated with hepatic fibrosis and disease
To assess whether Kupffer cell activation and the presence of bacterial products in the liver
were associated with disease state and progression, we performed immunohistochemistry on
liver biopsy sections taken at study enrollment. The CD14+ cells co-stained for CD68+
(Figure 6A), suggesting they were Kupffer cells. A greater number of CD14+ cells per high-
powered field (hpf) was observed in subjects with severe (Figure 6A) than minimal (Figure
6B) fibrosis (median 38 vs 21, P=0.0002; Figure 6E). The number of CD14+ cells/hpf in the
liver predicted which subjects would progress to end-stage liver disease (median 39 in those
who progressed vs 26 in those who did not, P=0.01; Figure 6F). A high number of CD14+
cells/hpf was associated with poor synthetic function and portal hypertension, based on INR
(r=0.26, P=0.04; Supplementary Figure 2A), direct bilirubin (r=0.33, P=0.008;
Supplementary Figure 2B), albumin (r=−0.28, P=0.03; Supplementary Figure 2C) and
platelet counts (r=−0.33, P=0.009; Supplementary Figure 2D). Furthermore, a greater
number of CD14+ cells/hpf was associated with higher MELD scores (r=0.32, P=0.012;
Supplementary Figure 2E) and with a higher APRI (r=0.30, P=0.018; Supplementary Figure
2F), suggestive of fibrosis. There was no difference in the number of CD14+ cells in subjects
with HBV infection compared to HCV infection. Quantitative image analysis for the
percentage area staining positive for CD14 did not reveal significant findings or correlate
with the density of CD14+ cells, presumably because the density of CD14 staining differs
among cells.
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text:
Ratings based on 37 Verified Reviews
They paid and stayed. We double-checked.
4.8 Room cleanliness
4.7 Service & staff
4.7 Room comfort
4.7 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Everyoneby A verified traveler
Charming property and a peaceful stayPosted Jul 24, 2015
I had a really wonderful stay at Sweetfield Manor. The gardens are stunning and immaculately kept, and you can experience a very peaceful view at sunset from the treetop lookout. A generous breakfast and friendly staff completed the experience. And I was pleasantly surprised to be delivered a fresh coconut from the garden to sip on mid-morning as I relaxed by the pool.
for Couplesby Lori from Nashville
Great getawayPosted May 25, 2015 on Hotels
This was our first night of vacation in Barbados - and we were so sad to arrive late and not get to spend more time at the manor! The rooms are simple yet unique and classy, the breakfast was delicious, the people were wonderful, the patio looked like it would have been a perfect place to spend a day. We would love to go back and spend more time at Sweetfield Manor
for Everyoneby A verified traveler from UK
Beautiful old housePosted May 12, 2015
Pros: Rooms, garden, pool, breakfast, staff
Cons: Attention to detail: our bathroom plug needed fixing, dead ants we sprayed weren't swept up for two days, some paintwork needs renewing
Location: Out of town so quiet and relaxing, but that means a taxi/bus ride (easy and affordable) to nice eateries and beach, although nice lunch snack bar near
This is a beautiful old house (c 1900) with a pleasant garden - plus peacock! - and a small pool and jacuzzi set in tropical vegetation. House has lovely verandahs, cool shaded areas, smart new bathrooms. Service is excellent, and breakfast is a four course affair with a different menu each day. (This is a b&b so no other meals are served).
for Personal Eventby Philip from UK
Barbados beautyPosted May 10, 2015 on Hotels
The hotel has an amazing setting with lovely gardens and a beautiful swimming pool. The breakfast was a highlight of the stay and the staff were both friendly and helpful. Would thoroughly recommend the hotel....
for Business Travelersby Declan
Posted Apr 22, 2015 on Hotels
for Everyoneby A verified traveler from Toronto, Canada
Fantastic B & B in BarbadosPosted Mar 31, 2015
Location: Its right in St. Michael, the place to be in Barbados.
Sweetfield has an old world charm in an ideal setting. The gardens are beautiful as is the view of the ocean. I love their KOI Pond. The surroundings are tranquil and watching the Peacocks strut about gives the impression of being in a lush garden .. All in all a superb place to stay with Gourmet breakfasts every morning. You couldn't ask for much more.
for Everyoneby A verified traveler from Germany
Just AmazingPosted Mar 23, 2015
I stayed for two weeks at the Sweetfield Manor. Michelle, Paul and the staff did everything to make it an unforgettable time. Thank you so much! The breakfast was delicious and lovely. To sit in the beautiful garden is a great way to relax and if it is possible i will definitely come again.
for Familiesby Armand from Atlanta
Fantastic property and servicePosted Mar 16, 2015 on Hotels
The property is gorgeous, huge rooms, the best showers, very nicely appointed common areas, wonderful garden with several semi-private areas, pool, koi pond, etc. The three course breakfast is a work of art and service is outstanding. The location is in a residential area so a car or a taxi is necessary. Brownes beach is a 5 min drive and all the restaurants at the Gap are 10-15 mins away. Perfect for couples, OK for families with older children. Families with young children should probably look somewhere else. All in all fantastic!
for Everyoneby A verified traveler
Posted Mar 10, 2015
Excellent B&B. Only disavantage is that it is not within walking to markets or dinnig.
by A verified traveler from Huntsville, AL
Rustic and Charming - but....Posted Mar 5, 2015
Plus- the grounds and Inn are beautiful. The peacocks roaming the grounds was a real treat. Breakfast was delicious and the room had great view. They picked us up from the airport for a nominal fee and even drove us to get some lunch when we arrived. The Staff was polite. Minus - It is not in the best part of town however and there is no where near to eat. We were also not given any "tour" or information about the inn when we arrived. We felt very "dropped off with no direction". While I realize this is not a hotel - a LITTLE direction would have been helpful. We were not even sure if it was OK to leave the grounds at night as the area seemed dodgy and there were large gates with barb wire around the inn.


text:
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Sport N FunRead MorePutting requires intense concentration, which is especially difficult when you have an elephant standing over your shoulder. At Sport-N-Fun, miniature golfers putt their way through three 18-hole courses adorned with statues of exotic wildlife such as gorillas and giraffes. These distractions are one of the many obstacles on the terrain, where bank shots and undulating hills stand between players and holes-in-one. Sport-N-Fun's other exhilarating Activities likewise vie for visitors' attention. Thrill-seekers zip around the curves and down the straightaways of the Go-Kart track, or leap skyward while securely harnessed on the bungee trampoline. In 7 batting cages, machines pitch balls toward batters at speeds of up to 85 miles per hour, offering hard ball or soft ball and a range of speeds for different skill levels. Inside, classic games blip and bleep as players frantically tap arcade buttons. Amidst all the action, GG's Pizza renews energy with servings of Pizza and Fountain Drinks.30749 Grand River AveFarmington Hills, MI US


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Slim Shady is off the vodka
Lyric Meaning
Slim Shady, Eminem's alter ego is crazy, and kills and rapes people all the time.
Also a reference to a lot of his songs I just drank a fifth of vodka, dare me to drive?
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College of Engineering University of Massachusetts Dartmouth
College of Engineering University of Massachusetts Dartmouth
School Links
- College of Engineering
- Degree Programs
- 5 Year BS/MS Programs
- Post-Bac Certificates
- Apply Now
- UMassD Grad School
A Top College of Engineering
The "U.S. News and World Report" gives the University of Massachusetts Dartmouth a ranking as a top-tier regional university in the Northeast and lists the College of Engineering among the top 50 undergraduate programs in the country. The university's 65 full-time professors bring in millions of dollars annually in grants from private agencies and national agencies to support groundbreaking research in many traditional and emerging fields including marine technologies, advanced materials, energy systems, intelligent systems, wireless networks and communications, computational physics, sustainability engineering, high-performance computing, biomedical/healthcare engineering, and biomimetic and composite materials.
Full-Spectrum Graduate Offerings
The College of Engineering at University of Massachusetts Dartmouth consists of six departments: bioengineering; civil and environmental engineering; computer and information science; electrical and computer engineering; mechanical engineering; and physics. The college offers a range of Master of Science (MS) degrees from these departments and PhD degree programs in Electrical and Computer Engineering and Engineering and Applied Sciences.. The college also participates in the interdisciplinary biomedical engineering and biotechnology PhD program. The College of Engineering also awards several certificate programs.
Graduate Programs in Electrical and Computer Engineering
The Department of Electrical and Computer Engineering at UMass Dartmouth offers a PhD, an MS, and a 15-credit graduate certificate program. Students may complete their programs on a full-time or part-time basis. Courses are offered at times that accommodate the schedules of working professionals.
Research foci include signals and systems; applied electromagnetics; applied acoustics; electronics and solid-state devices; database systems; embedded systems; artificial intelligence, database systems, and Internet computing; multimedia communication; biomedical computing; and reliability, security, and fault tolerance.
PhD in Biomedical Engineering and Biotechnology
UMass Dartmouth grants an interdisciplinary, nationally-recognized PhD in Biomedical Engineering and Biotechnology that combines engineering, technology, and biology. The program focuses on research in bioengineering, biomaterials, and microbe, animal, and plant biotechnology. The program is a partnership of the Departments of Mathematics, Chemistry and Biochemistry, Biotechnology, Biology, Mechanical Engineering, Civil and Environmental Engineering, and Medical Laboratory Sciences.
PhD in Engineering and Applied Sciences
The program offers five interdisciplinary options - Applied Mechanics and Materials, Computational Science and Engineering, Computer Science and Information Science, Industrial and Systems Engineering and Clinical Laboratory Science. The crosscutting options provide students with the means to integrate and synthesize disciplinary depth with breadth of interests, visions, and skills for successful interdisciplinary research careers in industry and academia.
MS in Mechanical Engineering
The Department of Mechanical Engineering, offers a master's program with three tracks: a coursework option, a thesis option, or a project option. Courses are scheduled during the late afternoon and early evening to accommodate working professionals. State-of-the-art laboratories support research in energy systems, fluid ¿ structure interaction, advanced materials, cell/tissue preservation, complex flows, micro mechanics, industrial design and automation, and other areas.
MS in Civil and Environmental Engineering
The Department of Civil and Environmental Engineering offers a master's program that works closely with local government agencies, small businesses, and industries to conduct research on and overcome the challenges associated with nation's infrastructure. Areas of specialization include water resources, geotechnical engineering, transportation engineering, environmental engineering, structural engineering and applied mechanics.
MS in Civil and Environmental Engineering
The Department of Civil and Environmental Engineering offers a master's program that works closely with local government agencies, small businesses, and industries to research and overcome the development and infrastructure problems. Areas of specialization include hydrology, geotechnical engineering, transport engineering, and structural engineering and applied mechanics.
MS in Computer Science
The MS in Computer Science program focuses not only on coursework in theory, applications, systems, and software development, but also helps students to develop their skills through realistic scale projects within the courses. Areas of specialization range from network engineering and science to security to intelligent agents to e-commerce.
MS in Physics
The MS in Physics program at University of Massachusetts Dartmouth is ranked as one of the top physics MS programs in the country by the American Institute of Physics. The Physics Department offers coursework in a broad range of topics including computational physics, mathematical physics, quantum mechanics, relativity, astrophysics, electrodynamics, fluid physics, and nuclear physics.
The program prepares both part-time and full-time students for careers in teaching, research, or industrial research and development. Graduate students choose from three tracks: MS with thesis; MS with research project; and MS with comprehensive examination.
The University of Massachusetts Dartmouth
The University of Massachusetts Dartmouth is located in North Dartmouth, Massachusetts in the northeastern region of the United States. It is one of five campuses in the world-renowned University of Massachusetts system.
Established in 1895, today it is highly-regarded for its outstanding academic programs, personalized teaching methods, and ground-breaking research. The University of Massachusetts Dartmouth is a supportive community that embraces diversity. It provides its students with the resources needed to excel academically, professionally, and socially, including housing, health, counseling, academic advising, and career services.
Location & Contact
College of Engineering
University of Massachusetts Dartmouth
285 Old Westport Road
North Dartmouth, MA 02747-2300
United States
Dr. Robert Peck
Dean, College of Engineering
Phone: 508-999-8539>
Fax: 508-999-9137
Email: email@example.com
Steven Briggs
Director of Marketing and Recruitment for Graduate Studies
Phone: 508-999-8604>
Fax: 508-999-8183
Email: email@example.com
Departments & Programs
- Department of Bioengineering
- Department of Civil and Environmental Engineering
- Department of Computer Science
- Department of Electrical and Computer Engineering
- Department of Mechanical Engineering
- Department of Physics
- Program in Biomedical Engineering and Biotechnology
- Program in Engineering and Applied Science
Degrees & Award
- Degrees Offered
- Major Degree Levels Offered
Postbaccalaureate Certificate
Doctor of Philosophy (PhD)
Master of Science (MS)
- Degrees Awarded
- Master's Degrees 49
- Doctoral Degrees 9
- First Professional Degrees Not reported
- Other Advanced Degrees 1
- * Shows the number of degrees awarded for the last academic year that data was reported.
- Earning Your Degree
- Part-time study available? Yes
- Evening/weekend programs available? No
- Distance learning programs available? Yes
- Terminal master's degree available? Yes
- Degree Requirements
- Master's Degrees
- Doctoral Degrees
- First Professional Degrees Not reported
- Other Advanced Degrees Not reported
- Acceptance Rate
- Applied 417
- Accepted 261
- Acceptance Rate 62
- Enrolled 78
- Applying
- Application Fee - Domestic $60
- Application Fee - International $60
- Electronic applications accepted? Yes
- Applications processed on a rolling basis? Yes
- Application Deadlines
- Type Domestic International Priority Date
- Fall deadline Not Reported Not Reported Not Reported
- Winter deadline Not Reported Not Reported Not Reported
- Spring deadline Not Reported Not Reported Not Reported
- Entrance Requirements
- Master's DegreesGRE (UMass Dartmouth bachelor's degree recipients are exempt for some programs), statement of purpose (minimum of 300 words), resume, and 3 letters of recommendation, official transcripts
- Doctoral's DegreesGRE, statement of purpose (minimum of 300 words), resume, and 3 letters of recommendation, official transcripts
- First-Professional's DegreesNot Reported
- Other Advanced Degreesstatement of purpose (minimum of 300 words), resume, official transcripts
- International DegreesTOEFL required, 533 paper based, TOEFL iBT, IELTS required, IELTS paper based
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- Tuition & Fees *
- Tuition & FeesNot Reported
- *Average dollar amount (tuition & fees) required to complete the degree
- Financial Support
- Financial award applicants must submitFAFSA
- Application deadlines for financial awardsMarch 1
- Types of financial support availableFellowships, Research Assitantships, Teaching Assistantships, Federal Work-Study, Financial Support for Part-time Students, Graduate Assistantships
Student Body
- Gender
- Total Graduate Students254
- Female Percentage24%
- Male Percentage76%
- Participation
- Total Graduate Students254
- Part-time Percentage36%
- Full-time Percentage64%
- Ethnicity
- Hispanic / Latino5%
- Black / African American2%
- White / Caucasian83%
- American Indian / Alaskan Native0%
- Asian6%
- Native Hawaiian / Other Pacific Islander0%
- Two or more races3%
- Unknown1%
- Faculty Breakout
- Total Faculty62
- Full-time Percentage90%
- Part-time Percentage10%
- Female Percentage15%
- Male Percentage85%
- Existing Research
- Focus of faculty researchRegenerative and bioactive materials, bioreactors and waste conversion, water/wastewater treatment systems, highway sustainability, human-computer interaction, visualization and imaging, computer engineering, cybersecurity, biopreservation, renewable energy, fluid structure interaction, amophysics, astrophysics, computational and theoretical physics, tissue/cell engineering, biotransport sensors/networks, comparative immunology, vaccine design, biosensors
- Externally sponsored research expenditures last year$10,023,000


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good workouts to try out. its always good to stay fit
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Adobe has elicited an apology from an employee that posted an anti-Apple, pro-porn message on its corporate blog over the weekend.
In protest against the iPad not offering Flash support, Lee Brimelow a "platform evangelist" for Flash, posted screengrabs of many popular sites showing blue legos where the Flash animation or video would be with the line "millions of websites use Flash. Get used to the blue legos".
One of the screen grabs was from the "World Famous Bang Bros" (in HD) clearly a porn site. The move was widely reported, by Pocket-lint too, to show that Adobe was using porn - or lack of it more accurately - as a way to show iPad users what they will be missing. It seems this did not go down well with Adobe big-wigs.
Brimelow has updated his post with the following: "Firstly, this is not the official Flash blog of Adobe. I am one of hundreds of employees that blog. Secondly, regarding the screenshot of the adult website, that was added by me in an attempt to be humorous. Not surprisingly Adobe did not find this humorous at all and that is why I removed it".
"There is no official Adobe movement to 'play the porn card' like some 'news' outlets are reporting", says the evangelist with the hyperlink behind that loaded "news" leading, rather rudely, to Wired.
Stating that he "overlooked the fact that some people are offended by the idea of adult content on the web" and that he loves his iPhone, Brimelow has now removed the offending screenshot.
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10-Minute Tricks to Freshen Your Space
Three interior design pros offer dozens of quick, easy and dollar-conscious ways to freshen up your living space before the flowers start to bud.
By: Stacy Gilliam
The calendar still reads "winter." But your mind can't help but flood with images of blooming tulips and daisies, gleaming sunshine and a home bursting with spring flavor.
You've already got the fever, my friend, the fever for a change in décor. Weary of the dark, drabness of the winter months, you're itching for the light, energetic mood of the spring season. But who has the bandwidth or the bucks?
Three interior design pros – Lauri Ward, Lisa Turner and Candace C. Peters – whipped up dozens of quick, easy and dollar-conscious ways to freshen up your living space before the flowers start to bud. Here's what you can do in no time:
Rotate art
Are your walls all cluttered with stagnant artwork? Then it's time for a change. "Some people hang everything they own on every wall," says Ward, the pioneer of "one-day decorating" and author of "Home Therapy: Fast, Easy, Affordable Makeovers" (Penguin Group, $34.95). "Look at it all the time, and you start taking it for granted." Try this: Separate art into summer and winter piles. Hang the lighter, pastel colors for spring and summer, and put the deep, oil paintings in storage. Every six months, rotate your pieces. "This way, you enjoy your art with a new vigor, and it's something you can do in minutes." Ward also suggests art collectors leave one blank wall in each room. It gives visitors a place to rest the eyes.
Soothe the senses
Spring is not only a colorful season, but a fragrant one, too. Bring the aroma indoors. "Scents have a profound effect on mood," Peters says. "Infusing scent into your décor with diffusers, candles, fresh cut plants/flowers, or incense can change the overall feeling of a space." Ward offers this quick, floral tip: Purchase an inexpensive bouquet of flowers. Split flowers up by color, and place each bunch in small vases around your home.
Beautify your boudoir
Bright, new bedding can do wonders for your personal space. Tuck away the heavy, winter flannel comforter and pull out crisp linens with coverlets for color, Turner says. Bring in the spring with floral-designed spreads or colorful solids. Don't forget accent pillows for added style and comfort.
Buy new bulbs
You're thinking flower bulbs, right? Not a bad idea, but we're talking about light bulbs. Ward says many of us aren't using our lights properly. "In the winter, you need more light," Ward says. But in the spring you can get away with less. Swap your 60-watt bulb with a 3-way bulb to allow you to soften light in a room, she says. "It really makes a difference to have the flexibility." Look into energy-efficient bulbs, which may cost more than a standard bulb, but last longer and can cut down electric bills.
Let the sunshine in
In the winter, dull, dusty windows can go unnoticed. Shorter, darker days give us an excuse. But on the first day of spring, take advantage of the sunny season by giving the windows a wash. "People tend to let the windows go, and they don't get as much light," Ward says. "You can have a gorgeous room, but if the windows are dirty, it won't look as beautiful or as bright." For an added tip, Turner suggests pulling back dark window treatments and adding a shade or valance for a touch of color. Or, you can also replace window treatments with ecru or white sheers for an elegant look.
Update accessories
Just as you'd add a scarf or necklace to enhance an outfit, do the same with your home. "Dress your home like you would yourself," Turner says. "Look for great accent pillows in bright colors. Put away the winter throws and drape light, bright throws on your sofa. Pick out spring-hued vases or candles to boost a cocktail or dining room table.
Show off your collection
Everyone knows you love elephants. You've got an assortment of statues in every room! Experts say to centralize your collection in one spot so your space looks organized and your visitors can truly enjoy it. "It gives a more dramatic effect," Ward says. "If it's a small collection, anchor it on a tray. Then people will notice."
Lose the magnets
In just minutes, you can tidy up a kitchen by getting rid of the scraps of paper, business cards and take-out menus stuck to the fridge. If you have odds and ends everywhere, it looks messy," Ward says. "If you clear it, your kitchen looks neat."
Keep out things you use on a daily basis, the expert says. Invest in a pretty bulletin board to take care of important items.
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At a recent basketball game the Oconee County High School ninth-grade cheerleaders led the cheers. From left, Lisa Ashley, Morgan Dolbear, Anna Long, Stacey Lee, Joanna Adams, Rachel Skipper, Jessica Salum, Jamie Sosbee, Lauren Gunter and Laura Leigh Crowe.
The Oconee County High School JV basketball cheerleaders are composed of Shannon Stansell, Lauren Burrell, Melissa Lawrence, Sabrina Robbins, Krystle Hill, Tallie Savage and Mandy Nash.
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Firefighters enter The Atrium mall on Bonifacio Drive, Iloilo City through an access door. Late night on Oct. 12, 2015 thick smoke billowed from the second floor, prompting the management to call for help. The smoke emanated from an oven of a bakery, according to probers. No one was hurt. JOSELITO VILLASIS/PN
After a slight rain afternoon of Oct. 13, 2015, this portion of Iloilo City's De Leon Street gets flooded. No thanks to the city's poor drainage system. The city government has so far not found a solution to this problem. JOSELITO VILLASIS/PN
Iloilo City's Barangay Edganzon chairperson Delia Dy leads the ceremonial opening of a basketball league for children. Sport and physical education is fundamental to the early development of children and youth. The skills learned during play contribute to the holistic development of young people. Through participation in sports, young people learn the importance of key values such as honesty, teamwork, fair play, respect for themselves and others, and adherence to rules. JOSELITO VILLASIS/PN
October 14, 2015
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As I've been exploring the new Google Photos, I have been increasingly impressed. I've started to appreciate just how significant a product it is, as it is the clearest confirmation yet of a trending shift in Google's approach to competing with Apple, how they are positioning themselves as a platform-agnostic service provider, and also what happens when you start to funnel back the power of Google's data insights and search algorithms into a product for the benefit of the consumer, rather than just for the advertisers.
Google are now platform agnostic
In the early days of Android, it was widely understood that Android represented a way for Google to to maximise its insights into its users as their activity would be totally within the Google ecosystem (as opposed to Apple's), thereby increasing the value of the data it could sell to advertisers. What appears to have changed, perhaps in part fuelled by the fact that at least half of Google's ad revenue is coming iOS (source: my memory of reading it all over the place), Google are now elevating themselves up the stack and treating iOS and Android as equals, delivering services of equal quality on both.
Yes, Google would prefer people to use Android, as there are some revenue streams Apple locks them out of on iOS (e.g. Maps, Siri), but with the simultaneous launch of Google Photos on both iOS and Android with identical features and both excellently designed and implemented, Google are no longer pro-actively trying to entice users away from Apple. Instead, they are now hitting Apple where it hurts – delivering services on iOS that are (arguably) better than Apple's own offerings. In order to benefit from the best of Google services, a user had to be on Android, but that is no longer the case. The Google Photos experience on iOS is tight, well-designed, slick, effortless and free.
So in other words, Google are (relatively) content now to leave iOS users as iOS users, so long as they use Google's services. Delivering excellent native apps with unbeatable pricing (what is cheaper than free?) is a very good way to do it, but they have an ace up their sleeve to really sweeten the deal…
They are using their data for good, and showing us the future
This is the clever bit. Google has built a business out of amassing user data, analysing it, and manipulating it into useful insights for advertisers, but until now they haven't applied that analytical engine to a consumer product, for the benefit of the users.
Unlike any other photos service I am aware of, Google Photos offers an unparalleled level of pro-active photo organisation and enhancements, and also a fully automated system of categorisation that allows you to search for anything without having to spend time in advance tagging. Essentially, all the user needs to do is take photos, and Google will figure out what albums to create, what enhancements to apply, and analyse them on the fly for their contents, so if you took a picture of a dog, the next time you search "dog", that photo shows up. It even recognises landmarks to include photos in location searches, so I could search for "dogs on beaches in France in 2008" and it will show me the relevant results without any manual effort by me.
It is really impressive, and to me feels like a glimpse of the future. When considering new technological advances that meet resistance, I like to ask "if someone with no prior experience of technology was shown the current solution and the proposed solution, which would they prefer?". If you asked this person if they would like to spend hours organising and tagging their photos, or whether it could be done for them, which do you think they would choose? The knowledge of where our files reside, and the notion of having control over them, are relics of an era where these things were required in order to obtain any benefit. There were no cloud services or good software, so people had to manage their photo libraries manually. But things have changed now – there is no longer a need to manage your files yourself – allow a company to do it for you and you'll reap the rewards of the latest and greatest technical innovations being served back to you in ways you could never achieve yourself.
Convenience and cost are mass-market factors. Google wins against Apple's cumbersome antiquated services on both counts. And here's the thing – Apple will never be able to compete with these new intelligence-based features Google is applying. They just don't have that level of data, and probably never will. At least, that is the common wisdom – that it is not possible to have the best search and services experience without giving up more personal data. Apple love to bash Google on privacy, but have not yet been able to show that they can match the power of Google's services and still allow users to retain their data privacy.
Users can have their cake and it eat
This is great for the users. An iOS user like me who has always preferred Apple's hardware but Google's software, can now truly get the best of both worlds without that many drawbacks. I can still enjoy the benefits of the Apple ecosystem where it benefits me (e.g. Continuity and Handoff), but I can also make use of Google's services just as well (e.g. Mail, Contacts, Maps and now Photos), without feeling like the two are working in opposition.
The strange thing is that Apple are still trying desperately to build competing services to Google, in order to lock people in to their hardware, but perhaps this is missing the point – users will happily stay on Apple hardware and use Google services – in this respect, Google is not as much of an enemy of Apple anymore, now that it isn't trying to poach Apple's hardware sales. Apple doesn't make money off services – these services exist purely to entice people into the hardware ecosystem. This means Apple's services will always be a second class citizen to their hardware. Google are now competing for services, on Apple's platform – a new dimension in this competition and one that Apple are going to have to really up their game to respond to.


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Cal Poly Pomona senior Nicoletta Stork is this week's California Collegiate Athletic Association Women's Volleyball Player of the Week for Sept. 7-13.
Stork led the Broncos to a 3-1 record with wins over Fort Lewis, New Mexico Highlands, and Westminster (Utah) at the Cal State San Bernardino-hosted Coyote Classic.
She tallied 64 assists, while also totaling 54 kills, 27 digs, and hitting a team-best .418 on the weekend.
Stork's two best performances of the tournament were in Friday's 3-1 opener over Fort Lewis and CPP's 3-0 finale victory over Westminster on Saturday.
Against Fort Lewis, Stork recorded a triple-double which included 11 kills and weekend-highs of 20 assists and 10 digs.
In the Broncos final game of the tournament, Stork hit a career-best .591 after smashing 13 kills in 22 attempts without a single error committed. She added 19 assist, four digs, and four blocks assists for a weekend-best 5.3 points per set.


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Featured stories about Kenya
Stories about Kenya
9 September 2015
Kenyan Public Intellectual Accused of Using Hate Speech on Twitter
Kenyan political analyst Mutahi Ngunyi apologises to the Luo ethnic group and Law Society of Kenya head by offering a goat and a beer after attacking them on Twitter.
15 August 2015
Are GMOs the Answer to Kenya's Food Security Issues?
Kenya looks like it is ready to get back on the GMO train. Is it right to?
6 August 2015
Meet the Humans of Kibera, Africa's Largest Slum
The story, in pictures, of the lives and challenges of residents of Africa's largest urban slum.
29 July 2015
Africans Take Jabs at One Another With #IfAfricaWasABar Hashtag
"If Africa was a bar, what would your country be drinking/doing?," Siyanda- Panda, a writer from Botswana, asked on Twitter.
To Ululate or Not to Ululate for President Obama? Kenyans Are Asking That Question
The art of ululation is very common in African culture. Was a Kenyan TV host who ululated while welcoming Obama being unprofessional?
13 July 2015
BAKE, an Organization That's Helping Kenya's Blogging Community Grow
The association has trained over 1,500 people on blogging, social media and online community management. One day, they hope to "help set up blogging associations in all the African countries."
25 June 2015
Take a Look at the Africa the Media Never Shows You
Western media tends to portray Africa as a dark, hopeless place. African Twitter users have rallied under the hashtag #TheAfricaTheMediaNeverShowsYou to prove that's not true.
19 June 2015
The State of Blogging and Social Media in Kenya Today
BAKE, the author of a new report, represents a group of Kenyan online-content creators and seeks to empower innovation and improve the quality of content created on the Web.
18 June 2015
Kenyan Blogger Bogonko Bosire is Still Missing, Nearly Two Years After His Disappearance
Controversial Kenyan blogger Bogonko Bosire went missing two years ago. Kenyans have revived his search with the hashtag #WhereIsBogonkoBosire.
15 June 2015
Arbitrary Arrests, Cybercrime, and Mass Mobile Adoption: Monitoring Digital Rights in Sub-Saharan Africa
Global Voices speaks to Tom Rhodes, the East Africa representative for the Committee to Protect Journalists, about the state of freedom of expression online in Sub-Saharan Africa.
23 April 2015
Kenyan Lives Matter, African Students Say at Garissa Vigil in Beijing
A group of African students in Beijing organized a vigil to honor the 147 victims of the Garissa attack. China has little tolerance for shows of public sentiment, even grief.
6 April 2015
The 147 People Killed in the Garissa Attack Are More Than a Statistic
Twitter users have started using the hashtag #147notjustanumber to celebrate the memory of those slain when armed militants stormed Garissa University College.
After Gunmen Kill at Least 147, Where Is the World's Solidarity With Kenya?
The Charlie Hebdo attack sparked unprecedented solidarity worldwide, but Kenya's tragedy has elicited a less enthusiastic international response.
23 March 2015
Why Are Mostly Foreign Artists Representing Kenya at the Venice Biennale?
If you visit Kenya's pavilion at the Venice Biennale, you will meet 'Kenyan' artists such as Armando Tanzini, Qin Feng, Shi Jinsong, Li Zhanyang, and Li Gang.
21 March 2015
Are These Wild Ideas Our Last Hope for Saving Africa's Rhinos?
From fake horns to relocation, today's wildlife protectors are enlisting new — and often unproven — strategies to save endangered species.
9 March 2015
Can Mock Hunts Save Lions in Kenya and Tanzania?
Maasai warriors and biologists are teaming up in Kenya and Tanzania to defuse human-lion conflict in Kenya.
5 September 2014
Activists and Bloggers Worldwide Ponder Lessons Learned From the ALS Ice Bucket Challenge
There is no denying that more people are now more aware of ALS than ever before, but critics have accused the campaign of focusing on self-congratulating deeds.
24 July 2014
5 Modern African Thinkers on Identity, Language and Regionalism
Albeit a bit of a mystery worldwide, African philosophy is strong discipline that has evolved tremendously through history.
3 July 2014
How Technology Is Helping People Learn—and Even Save—the World's Languages
Forward thinkers are harnessing the unprecedented power of technology to bring languages back from the brink of extinction, and in rare cases, to resurrect an extinct language.
23 June 2014
TV Networks in Africa Squabble Over World Cup Broadcast Rights
Thanks to legal battles and network decisions, some fans on the continent might have a more complicated time tuning in to the World Cup.


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Health & Pregnancy
Pregnancy and Drugs (Prescription and OTC) Directory
Back to Pregnancy and Drugs (Prescription and OTC) Home
Pregnancy and Drugs (Prescription and OTC) News Archive
Sort by: Date A-Z
- Fish Oil for Moms May Benefit Babies
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- Antidepressants and Pregnancy OK?
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- Taking SSRIs in Pregnancy Affects Infant
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- Early Pregnancy Risk With Ginseng
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Today on WebMD
Track your most fertile days.
Week-by-week pregnancy guide.
The signs to watch out for.
Are there ways to do it naturally?


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Mobile Breast Cancer Screening
Date: Call 503-681-4035 for dates and locations.
Location: Mobile
Description: Looking for a mammography alternative closer to you? Tuality's mobile mammography vehicle with new state-of-the-art digital mammography… More Info
Category: Cancer Awareness Women's Health
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Category: Cancer Awareness


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3701-3761 Preamble Lane
A location in Yorktown
Commute to Downtown Newport News
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Some errands can be accomplished on foot.
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3701-3761 Preamble Lane has a Walk Score of 53 out of 100. This location is Somewhat Walkable so some errands can be accomplished on foot.
Nearby parks include Wolf Trap Park, Chisman Creek Park and Newport News Park.
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