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BREAKING JERUSALEM - LIVE FEED: Israeli Forces Take Control of Dome-of-Rock / Temple Mount - Injuries Reported!
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AI is clearly a disinfo agent.. and i'm shocked more intelligent people (more intelligent than I) that frequent this space and post at a much higher rate don't speak out and call a spade a spade.
Is AI some sort of sacred cow?
He clearly avoids points that discredit his shilled belief system and constantly discredits any belief that isn't his own.
He regularly recites disinfo from Zeitgeist, and speaks of it to be truth and fact, when, in reality, its easily dispelled and shown to be a clear and present attempt to nullify the Son of God and the great works He did for all of MANKIND.
From this point forward, I will not read any disinfo AI attempts to propagate and I suggest everybody else does the same. If you don't feed the shill eventually it will die and fade into oblivion.
Anonymous Coward 22610784
i dont believe that at all and i happen to love the word of God and the message of Jesus Christ. i follow it daily. i dont agree with everything AI says but he has actually opened me up to far wider interpretation of the work of God than i would have ever come to listening to some church doctrine and interpretation. if you think it is an impossible theory that reformation churches could have added info and importance to certain biblical applications in order to retain or acquire power than you are just blind yourself and you probably wont get it.
the only place we differ is that i see there is absolutely something to what AI has to say. my belief is that it goes along with the word and it is the result of creation. i see it as something only a brilliant God could do. to tell the story of His creation within the heavens is amazing to me. also if you have truly read the word you have to stop believing it is something that we are supposed to just accept on blind faith. there is more logic to scripture than any pastor cares to teach.
can you see any benefit of a tithe collecting curch to want people to depend on their interpretation instead of thinking on their own? i will give you a hint... it isnt cause they are worried about your soul! i am not saying all pastors have an agenda. i am saying it has become tradition and expected from congregations. as soon as the bills start to come in it is impossible for ANY pastor to not have an agenda from that point on. people want to be shepherded blindly. that is an easy walk through life. my point is there are mysteries in the bible. there are amazing adventures with God and it isnt just when we die and get to heaven. there is a reason solomon knew the seals of angels. you just need to dig a little deeper.
Anonymous Coward 23739682
Thank you friend ! Wise words ! Its why they call it the pearl of high price. We have to keep on learning to the state of Gnosis..
Matthew 13:46 When he had found one pearl of great price. He was willing to invest everything he had in this pearl of surpassing beauty and worth.
Many christians are just used to sitting down and staring up at the Pastor at the Pulpit without thinking and examining things for themselves.
Its why every Christian should read literature and wisdom of Jewish Rabbis. They get you to think and ponder for yourself . They offer some of the pearls of high price that can get you to rethink and leave everything else one has learned
Its why we have to be open minded and consider that there is always more discoveries and mysteries to unveil.. Life is a never ending grand design of sacred science that on by one leads us to learn of immortal life...
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"Camping" on Your Own Land is Now Illegal — Gov't Waging War on Off-Grid Living
Media Continues to Call for the Use of Gov't Force to Confiscate Millions of Guns
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According to ProFootballTalk.com, Patriots tight end Rob Gronkowski will likely be cleared and play this week.
Per league source, Rob Gronkowski is expected to be cleared this week and it is likely he will play on Sunday against the Saints.
— ProFootballTalk (@ProFootballTalk) October 8, 2013
Gronk will give the Patriots offense a new look as long as he stays healthy.


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Mobile Extras
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The Best iPhone 6/6 Plus Running Band TuneBand for iPhone 6 & iPhone 6 Plus
After 30 hours researching and testing 26 armbands and waist packs, we found the TuneBand for iPhone 6 and 6 Plus are the best armbands for running. While most running bands are one-strap-fits-most, these come in large and small sizes. Plus, unlike the competition, the TuneBand offers an open-front, silicone skin that allows for direct access to your phone's screen and all its buttons. Read More >
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The Palgrave Handbook of Social Democracy in the European Union
Jean-Michel de Waele, Fabien Escalona, Mathieu Vieira
Palgrave Macmillan, Oct 25, 2013 - Political Science - 632 pages
The character of social democracy in the constituent countries of the European Union is more significant and much better understood than the available literature would appear to suggest. This thought-provoking and edifying handbook aims to redress this disparity by bringing together a range of top political scientists from across Europe to provide a definitive collection on social democracy in the EU, one that offers students and scholars both an informative and easy-to-use guide to social democracy as a system of governance in Europe.
Through establishing a common framework for analysis and by exploring all 27 countries in the European Union according to this structure, The Palgrave Handbook of Social Democracy in Europe constitutes a compendium that is truly comparative in nature. This comparative and comprehensive framework coupled with the unprecedented overview of European social democracy over the past decade makes this handbook the go-to guide for those interested in all aspects of social democracy in the European Union.
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alliance campaign candidate center-left center-right coalition Committee Communist Party Constitution Council crisis ČSSD cultural Cyprus date accessed defeat democracy Democratic Left Alliance economic EDEK electoral results Estonian Europe European elections European social factions favor Federal Fianna F�il government participation government's Hungarian Socialist Party ideological internal Intra-party issues Labour Party Latvia left-wing liberal LSAP LSDP LSDSP majority Malta membership movement MSZP multi-level organization municipal number of members opposition organizational �VP Papandreou parliamentary elections Partito Democratico party congress party leader party leadership party members party organization party's PASOK People's Party percent political parties President presidential election Prime Minister PSOE PvdA referendum reform regional representatives Republic role Romania Seats number Secretary sector Seimas Smer-SD Social Democratic Party Socialist Party Sociology SP.a SP� statutes strategy structure Swedish Table tions trade unions vote voters welfare workers


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Welcome to Gastown
Gastown on Instagram in MayFriday, 29 May 2015 07:00
May flew by as we honoured mom, gathered in Maple Tree Square for James Vincent McMorrow, welcomed a Michelin star chef and celebrated bike to work week.
Two Wheel Gear: From the Bike to the BoardroomThursday, 28 May 2015 09:30
With Vancouver's influx of corporate bike commuters, Two Wheel Gear has come up with an elegant solution that will take business commuters from the bike to the boardroom in style.
Dogs of Gastown: Meet DustyWednesday, 27 May 2015 08:00
Imagine if Justin Bieber tried to buy you. Well, it happened to our latest addition to the Dogs of Gastown family. Meet Dusty.
Meet Braden Parker & His Two Wheel "Black Beauty"Tuesday, 26 May 2015 08:00
Since it's Bike to Work Week, we caught up Braden Parker - a young associate with a sharp sense of humour and stylish ride. When he's not working to help revitalize some of Gastown's coveted properties, you might catch him…
THINGS TO CHECK OUT THIS WEEK IN GASTOWNMonday, 25 May 2015 08:54
What's happening this week in Gastown? Here's a non-exclusive list of new things to keep on your radar.
Gastown on the Small ScreenFriday, 22 May 2015 09:30
Recently, Gastown has seen the likes of costumed superheroes, whimsical spirits, and other interesting faces from some of the hottest shows on television. Here's a look at some of the notable characters spotted around the neighbourhood.
Before Bauhaus, There was The Boulder HotelThursday, 21 May 2015 08:00
The corner of Carrall and Cordova is buzzing with the opening of Bauhaus Restaurant. The new establishment showcases upscale German cuisine inside one of Gastown's most celebrated buildings, The Boulder Hotel. In honour of their opening, we dug through the…
Truvelle Bridal Steps Out of the Studio for a Summer Pop-UpWednesday, 20 May 2015 08:00
It's a nice day for a white wedding. Ok, maybe not today, but it is the start of the season and to celebrate, Gastown's Truvelle is hosting a pop-up shop on Abbott.
THINGS TO CHECK OUT THIS WEEK IN GASTOWNTuesday, 19 May 2015 08:30
A non-exclusive list of new things to keep on your radar.
Celebrating 45 Years of FluevogFriday, 15 May 2015 08:39
In honour of International Fluevog Day and the company's milestone anniversary, let's flashback to 1970, when John first began his life-long love affair with footwear.
How to Gastown Like a LocalThursday, 14 May 2015 08:00
Want to learn how to Gastown like a local? We've put together a series of guides to share how our locals like to spend a day in Gastown. These locals or Gastowners are the best source for finding out how…
All in the Family: Old Faithful ShopWednesday, 13 May 2015 08:00
Would you open a business with your brother, your mother or the one who pledged to spend their life with you? Gastown is home to a handful of businesses that keep things all in the family.
James Vincent McMorrow Plays Live this Saturday in GastownTuesday, 12 May 2015 08:00
The Red Bull Tour Bus pulls into Gastown on Saturday for a free outdoor concert event with James Vincent McMorrow – and it's free.
THINGS TO CHECK OUT THIS WEEK IN GASTOWNMonday, 11 May 2015 08:00
Maple Tree Square will become concert grounds for a free live music event. The list also includes dim sum nights at Bambudda, International Fluevog Day, the Nicole Bridger Shop & Show and Pints for a Cause.
Don't Blow it This Mother's DayFriday, 08 May 2015 08:00
Mother's Day is this weekend. Still stumped? Give her a little Gastown.
New Gastown Eatery Tempts Locals to 'Bao Down'Thursday, 07 May 2015 10:00
Vancouver is chock-full of Asian offerings, but despite the surge, it's hard to find bao steamed buns and hawker-style eats. That's where Bao Down comes in. The eatery opened to a welcoming reception and is already serving up a new…
Red Bull Tour Bus Rolls into Gastown with James Vincent McMorrowWednesday, 06 May 2015 08:00
Patio season has arrived and with it, our first outdoor event of the year. If you love live music, Gastown is the place to be on Saturday, May 16th.
This is #MyGastown - with Christy Lum (aka @1000simplemoments)Tuesday, 05 May 2015 08:00
Want to see Gastown the way we see it? We're enlisting the people who live, play and work in the neighbourhood to give you an insider's look. Welcome to #MyGastown.
THINGS TO CHECK OUT THIS WEEK IN GASTOWNMonday, 04 May 2015 08:00
What's happening in Gastown? This week's list includes new creations at Blacktail Restaurant and Notturno, One of a Few's #BoutiqueLove party, the 'All About Mom' dinner at Secret Location, and more...
Skip the Mall, Give Mom a Little Gastown This YearFriday, 01 May 2015 08:00
With a week to go until Mother's Day, we've been walking the neighbourhood in search of unique gift ideas in Gastown.
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Category: Other
MHL Consortium shows some of the latest MHL features
There are now 2 HDTVs that are MHL compliant, the Toshiba WL800A and the Samsung UN46D7000 now also got a firmware update that ads MHL support. Possibly that all new HDTVs will include this functionality. It allows for charging MHL compliant phones and tablets and to remote control them with the TV remote through one simple cable and one Micro-USB connector. Android 4.0 Ice Cream Sandwich might add new MHL features to the UI, otherwise the MHL Consortium is trying to convince app developers and smart phone makers to design the apps and the OS to take advantage of the 1920x1080 resolution of the HDTV when using the HDMI output, to provide higher resolution user interfaces, higher resolution games, the ARM Processors and GPU in those phones and tablets are now getting powerful enough to output full 1080p UIs, videos and graphics, it's time for the industry to take advantage of that! One pocketable phone can now combine the features of Android, Chrome OS and Google TV, it's now a phone, a desktop, a set-top-box and a home console all in one!
B Labs demonstrates Virtualizating 2 OS on ARM
B Labs can run 2x Android OS, for example one secure business install and one for personal use, or to run Android and a version of Linux.
FirstView pre-approves outsourcing partners in India for US
FirstView pre-approves potential outsourcing partners and suppliers in India and elsewhere, to enable reliable outsourcing of ARM related PCB design and other ARM optimizations work, tablet, set-top-box designs and more.
ARM Cortex-M4 hardware accelerated Mp3 playback
ARM Cortex-M4 with a DSP in the Freescale K60 Tower Board to demonstrate hardware accelerated Mp3 playback.
Update on the ST Ericsson SNOWBALL ARM Cortex-A9 development board
The SKY-S9500-ULP-CXX aka SNOWBALL has been available as a development board for the ST Ericsson ARM Cortex-A9 processor for about 4 months now. Here's an update on how they are doing. Find more at http://igloocommunity.org
Ericsson HSPA+ and LTE modems
Ericsson is one of the leaders in cellular network infrastructure, for the past 4 years they also make HSDPA, HSPA+ and now also LTE modems to embed in Tablets, Laptops and more.
Microsemi Smart Fusion Custumizable SoC
Rajiv Nema, product line manager, describes how Microsemi's Smart Fusion works, to combined the ARM Cortex-M3 with FPGA to provide for customizable system on chip.
Mentor Graphics at ARM TechCon 2011
Mentor Graphics is one of the major EDA providers of the ARM industry. At their booth they are showing some impressive 3D graphical user interfaces that they say is easy and cheap to implement on ARM Powered devices to make them more appealing and to differentiate in the UI design, and they are also showing an auto-balancing lego robot built using Texas Instruments Sitara microcontrollers and the nucleus real-time software.
I'm Watch, i.MX233 Android Bluetooth wrist watch
They are launching before Christmas, it's a $299/299€ Android watch, running on the Freescale i.MX233 ARM9 processor, it has a 1.54" capacitive touch screen, with Bluetooth it synchronizes with any Android phone, iPhone or other smartphone, there is an API to adapt Android apps to it.
Toshiba presents their latest Cortex-M processors
Toshiba is doing a range of ARM Cortex-M series of processors used in a huge number of devices around the world.


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Nina Ricci
Paloma Dove Print Cropped Trousers
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Nina Ricci lends femininity to cropped trousers by softly tailoring the pair in Paloma dove-print silk crepe de chine. A back yoke gives the trousers a perfect fit. Wear with a crisp white shirt and tailored blazer for work, switch to a silk camisole and heeled sandals for evenings out.
- Navy/white Paloma dove print silk twill
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An air of romance and a sense of refinement are the hallmarks of every Nina Ricci creation. Founded in 1932 by Italian-born Marie "Nina" Ricci, this French fashion house offers polished clothing, shoes and accessories that epitomize la mode feminine. Known for his flattering silhouettes and creativity with fabric, newly appointed Creative Director Guillaume Henry brings an effortless elegance to the house's iconic style.
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Did Foley Win the Fruitcake Eating Competition?, NXT Tag Team Gets a New Manager, Natalya
by Amish Patel - December 08, 2013
– Natalya posted a Tout video on why she should win the Diva of the Year Slammy Award:
– Mick Foley came in 4th place at the International Fruitcake Eating competition in Santa Claus, Indiana on Saturday afternoon. Apparently Foley finished 1st but the win was thrown out after it was found he had a substantial portion of his fruitcake hidden under a napkin and the rest stuffed in his pockets. Foley noted on Twitter that he won a gold award for best attire. Here he is with his award:
– WWE NXT Diva Raquel Diaz, the former Shaul Guerrero, is apparently now managing the tag team of Mason Ryan and Jason Jordan.
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Information Technology jobs in North Metro
Found 2 jobsbetween $40,000 and $49,999 matching your criteria
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Join a company recognized by its employees as a Top Workplace in 2012, 2013, and 2014.
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Staffing Partners is looking for a Sales Representative for our client in a southwest Minneapolis suburb for a direct hire opportunity! Competitive...


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La Tourangelle Roasted Walnut Oil, 16.9-Ounce Unit
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100% Walnut Oil.
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This is suppose to be healthier and everything cooks finePublished 10 days ago by Jacqueline DelZoppo
Arrived timely in good condition with no leakage. We purchased this oil to use in place of less healthy corn or canola oil in recipes for pancakes, waffles, and other baked... Read morePublished 10 days ago by Art S
This is a delicious oil. The walnut flavor really stands out. We keep this oil in the refrigerator, to preserve freshness and taste. Definitely shake it well before each use. Read morePublished 15 days ago by CC
this roasted walnut oil was excellent until it lasted. Now I am going to order a new bottle to replace this one.Published 16 days ago by Kurtis Mitchell


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Most Recent Articles In Memo Pad
Latest Memo Pad Articles
- The New York Times to Double Digital Revenue to $800M by 2020
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DANCING QUEENS: Longchamp is keeping Coco Rocha and Liisa Winkler on their toes. For its spring campaign, the French firm again put the Canadian models in the hands of a choreographer — this time, Salim Gauwloos, best known for his work with Madonna.
The print campaign, shot by Max Vadukul at the former TWA Terminal at New York's JFK Airport, shows them waltzing through security and twirling around the baggage carousel, toting bags such as the Longchamp 3D, the Gatsby Sport and the LM Cuir line, as well as sporting the brand's recently introduced shoes and ready-to-wear.
This story first appeared in the December 27, 2012 issue of WWD. Subscribe Today.
A campaign clip, by directing team Skinny, shows the pair being frisked by customs, then suddenly cavorting to the Bee Gees track "You Should Be Dancing."
Watch the Longchamp Spring Campaign here >>
"I was inspired by the image of the Longchamp woman, who is funny, free and sure of herself, and then I worked all these elements into a disco choreography," said Gauwloos. "We worked through the steps with Coco and Liisa, who are both fabulous women and actresses, and everything clicked — the energy was palpable."
The campaign is the second under Longchamp's "creative movement" concept, unveiled last year. It will launch in January in print, on billboards and on the Web. The clip will be unveiled on Feb. 12 on longchamp.com and social media, marking the launch of the brand's new site, conceived as a digital flagship.


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Children's Film Program
Families are invited to enjoy a wide range of innovative film programming—including classics, recently produced shorts, and foreign features. Films are selected to appeal to both youth and adult audiences; age recommendations assist parents in selecting the most emotionally and intellectually stimulating films for their children. Feature films are in English, unless otherwise noted.
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Bharti Airtel may be asked to stop 3G services in seven regions
Zeebiz Bureau
New Delhi: By the end of March, Bharti Airtel could stop providing 3G services to seven circles.
According to English daily, the Department of Telecom (DoT) could ask the leading telecom service provider to stop providing third generation (3G) services in seven circles where it does not have high-end data services. Airtel could be asked to stop the services within the next 15 days, the reports claimed.
Bharti Airtel could be fined a penalty of Rs 350 crore or Rs 50 crore each for the seven circles where it provides roaming 3G services through Vodafone and Idea, its main rivals, the report said.
Vodafone and Idea could face similar notice too, the report said however adding that the telecom minister Kapil Sibal has already approved the DoT's move to fine Airtel while nothing has been finalised on the other two.
In September 2012, the DoT had asked Airtel to terminate 3G roaming pacts in areas that it does not have third-generation spectrum but was offering services.


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|28. Nov. 2002
|22. Mai 2001
|22. Mai 2001
|Auch veröffentlicht unter
|Allan Kuchinsky, Katherine Graham, David Moh, Paul Meltzer, Yidong Chen, Michael Bittner, Michael Creech
|Ursprünglich Bevollmächtigter
|Allan Kuchinsky, Katherine Graham, Moh David Chitai, Paul Meltzer, Yidong Chen, Michael Bittner, Creech Michael L.
|Zitat exportieren
|BiBTeX, EndNote, RefMan
|Patentzitate (5), Referenziert von (15), Klassifizierungen (9), Juristische Ereignisse (1)
|Externe Links: USPTO, USPTO-Zuordnung, Espacenet
[0001] The present invention pertains to software systems supporting the information synthesis activities of molecular biologists, in particular the activities of organizing, using, and sharing diverse biological information.
[0002] As in many fields, research in molecular biology moves through an initial phase involving the formulation of models or hypotheses, into a middle phase where these hypotheses are tested through experiment.
[0003] In the early phase of model building and hypothesis formation, the investigator engages in speculation and hypothesis formation, identifying key elements, genes and proteins in molecular biology, and possible interactions of those key elements. In this early phase, the investigator is inferring causal relationships from correlations in test data, forming hypotheses which are to be refined and possibly tested.
[0004] The investigator in the field of molecular biology faces a daunting task in this early phase of model building. Unlike earlier endeavors where the number of possible variables was small, and experiments few and contained, investigators in molecular biology deal with enormous problems of scope.
[0005] Key elements, such as genes or proteins of interest, may number in the thousands, and the potential interactions may number in the billions. A single microarray experiment may produce megabytes of numerical data. The data is too large in scope to be held in the investigator's head.
[0006] To add to this problem, the investigator is faced with piecing together information from diverse sources and in different forms. This information is also geographically diverse, both in content and form, and may include public and private databases, textual information from publications, and experimental data both raw and refined. This data is also at multiple levels of abstraction, ranging from raw numerical gene expression data from microarray experiments, to textual descriptions of cellular processes.
[0007] The investigator must synthesize information in various forms from various sources into high level models.
[0008] Very few tools exist to support this abstraction and exploration process. What is needed is a system for assisting investigators in the organization, using, and sharing of this diverse biological information.
[0009] An interactive software system provides a framework, methodology, and tools for organizing information during speculative phases of research using a narrative structure. The system provides interactive tools and techniques for organizing, sharing, and using diverse information at multiple levels of abstraction through coordinated multiple-view visualization in the process of hypothesis formation.
[0010] The present invention is described with respect to particular exemplary embodiments thereof and reference is made to the drawings in which:
[0011]FIG. 1 shows the main windows of the invention,
[0012]FIG. 2 shows an item,
[0013]FIG. 3 shows the file menu,
[0014]FIG. 4 shows the Item Manager window,
[0015]FIG. 5 shows the Collection Manager window,
[0016]FIG. 6 shows a Collection Manager menu,
[0017]FIG. 7 shows the browser view of a story,
[0018]FIG. 8 shows a story in tree form,
[0019]FIG. 9 shows a story grammar, and
[0020]FIG. 10 shows an example story in XML form.
[0021] The investigator in the biological arts is inundated by data, data appearing in a myriad of forms and from a myriad of sources. From this vast amount of data, the investigator seeks to find needles of causality in haystacks of correlation.
[0022] The goal of the investigator is to piece together a "story" of what a gene or protein does, and how it interacts in pathways with other genes or proteins and their products. Such a story might portray a cascading set of proposed causal relationships between, for example, gene expression states, e.g. "the gene PAX3-FKHR induces the genes Myogenin and MyoD, which in turn induce the gene My14, which in turn causes muscle cells to fail to differentiate and exit the cell cycle, which in turn leads to cell proliferation and full malignancy."
[0023] Piecing together the story is an iterative and interactive process involving gathering information, organizing that information into concepts and categories, formulating and documenting tentative explanations and hypotheses, documenting those explanations and hypotheses via textual notes and graphical sketches, sharing those explanations and hypotheses with colleagues, and incorporating verification and feedback from colleagues into the story.
[0024] To support this iterative process, the system according to the present invention provides a coordinated set of interactive information organization and synthesis tools, built upon a simple conceptual model using a free-form database and a narrative structure, incorporating and building items, collections, and biological stories.
[0025]FIG. 1 shows the main windows of a system according to the present invention. In the preferred embodiment, the system is built as a java program to obtain portability across operating systems. Web and XML technology are used to represent and store information in a flexible fashion. While the implementation shown herein targets genes and gene expression, the techniques disclosed are equally useful for proteins and proteomics.
[0026] Items are handled by the Item Manager, shown in FIG. 1 as the Gene Manager window. Items are grouped into collections and handled by the Collection Manager. Multiple coordinated views of items and collections are supported, as is a desktop metaphor, the GS Desktop window of FIG. 1, for handling bookmarks and working sets of items and collections which may be the current focus of the investigation. Interactive updates to items in one view are reflected in changes in the corresponding views.
[0027] The Object Editor, not shown in FIG. 1, is a free-form tool provided for editing and annotating the properties and contents of items and collections.
[0028] The Story Editor shown in FIG. 1 is a syntax-directed editor in which a biological story is represented by a tree structure. The Story Editor provides a narrative structure for organizing information about the interrelationships and interactions amongst items and collections in biological pathways, and provides a way for the investigator to piece together and articulate an understanding of biological phenomena from diverse data sources.
[0029] The Pathway Editor allows the investigator to put together diagrams representing relationships between entities. The Pathway Editor also allows the construction of semantic overlays for items.
[0030] These components and their associated data structures are closely and consistently coupled. An interactive change to an entity in any one view is reflected in all other views. Consistency and close coupling of multiple views enables the investigator to simultaneously view information from a variety of perspectives and across different levels of abstraction. This facilitates the discovery of unforeseen interrelationships, this aiding the process of piecing together explanations and hypotheses.
[0031] Items are the basic or "atomic" units of information. They represent biological entities such as genes, proteins, sequences, or other products. Items contain detailed information about a biological entity, such as expression levels from microarray experiments. They also serve as repositories for links to detailed experimental data and public data, such as literature citations. The investigator moves Web based information on an entity into the item representing that entity by dragging and dropping (or cutting and pasting) text and/or URLs from a source such as a Web page (e.g. an NCBI Genbank entry for a gene) onto the appropriate item in the Item Manager.
[0032] In addition to providing ways for the investigator to manually enter links to detailed data, the system can also semi-automatically populate items with links to detailed data. For example, knowledge discovery and data mining tools can be utilized to retrieve pertinent literature references and database entries for an item.
[0033] In order to build new abstractions, it is often useful for the investigator to group together chunks of related information. For example, a set of genes known to influence muscle cell differentiation may be thought of together as a set. The system supports these sets through constructs known as collections. Collections are user-created, free-form sets of items.
[0034] The investigator groups items into collections by dragging and dropping items from the Item Manager onto the desired collection in the Collection Manager. The Collection Manager component is a tree view of collections; it functions in a way that is analogous to the tree view of folders in Windows Explorer. The investigator can create a new collection by using the add collection button in the Collection Manager.
[0035] The Collection Manager can also populate collections semi-automatically. One mechanism is by searching databases on a specified term. Using a dialogue box, the investigator enters a biological term of interest, for example, "kinase," and a collection will be built consisting of items from a database whose names have a match for that term.
[0036] Collections are very malleable; collections may be split or merged, items or groups of items may be added, deleted, or moved from one collection to another. Collections may be nested; a collection can contain other collections as well as items. Collections cam be overlaid with detailed experimental data, for example by overlaying a set of expression levels on a collection of genes and highlighting those genes whose expression levels exceed a certain threshold.
[0037] As with items, collections can serve as repositories for links to detailed experimental data and public data, such as literature references. The investigator moves Web-based information on an item into the collection representing the item by dragging and dropping (or cutting and pasting) text and URLs from a Web page (e.g. and NCBI Genbank entry) onto the appropriate collection in the Collection Manager.
[0038] The biologist's starting point is a detailed, biological dataset, for example a gene expression dataset. The dataset is imported from a relational database, spreadsheet, or other bioinformatics tool. For example, this dataset may come from a spreadsheet that contains the results of running a number of DNA microarray experiments. In the simplest form, each row of the spreadsheet represents one gene and each column represents one experimental condition.
[0039] Proceeding from this detailed microarray data, the investigator pieces together the "story" of what a gene does and how it interacts in pathways with other genes and gene products. Such a story might portray a cascading set of causal relationships between gene expression states, e.g. "the gene PAX3-FKHR induces the genes Myogenin and MyoD, which in turn induce the gene My14, which in turn causes muscle cells to fail to differentiate and exit the cell cycle, which in turn leads to cell proliferation and full malignancy" [Khan et al, PNAS].
[0040] Piecing together the story is an iterative process of
[0041] gathering information,
[0042] organizing that information into concepts and categories,
[0043] formulating and documenting explanations and hypotheses,
[0044] documenting those explanations and hypotheses (via textual notes and graphical sketches),
[0045] sharing those explanations and hypotheses with colleagues, and
[0046] incorporating verification and feedback from colleagues into the story.
[0047] The present invention provides a method to make explicit and keep organized the train of thought leading to the investigator's explanations and hypotheses. To support this iterative process of story development, the invention provides a coordinated set of information organization and synthesis tools, built upon a simple conceptual model that consists of items, collections, and biological stories.
[0048] Items are the basic "atomic" unit of information. They represent biological entities such as genes, proteins, sequences, and other gene products. Items contain detailed information about a biological entity, such as the expression levels from multiple microarray experiments. They also serve as repositories for links to detailed experimental data and public data, such as literature citations. The investigator can move Web-based information for a gene into the item representing that gene by dragging and dropping (or cutting/copying and pasting) text and URLs from a Web page (e.g. an NCBI Genbank entry for a gene) onto the appropriate item in the Gene Manager. A sample item is shown in FIG. 2.
[0049] The investigator begins by importing the detailed dataset into the Gene Manager component by using the Import submenu on the File Menu. The File Menu is shown in FIG. 3.
[0050] The Gene Manager component consists of a table in which each row corresponds to an item and each column corresponds to a value or property for that value. This is analogous to a spreadsheet or a relational database table. FIG. 4 shows the GeneManager.
[0051] Selecting the File=>Import menu, prompts for a file to import, via a "file chooser" dialog. The import operation imports a set of gene data. Data is imported in the form of a spreadsheet with tab-separated columns. Each row of the spreadsheet data is read and used to create a new item that is added to the GeneManager. Properties and values are assigned to each item based upon the information imported from the appropriate columns. In order to correctly make assignments to items and their data values, the program relies on conventions on how columns are named. These naming conventions require two lines at the beginning of the input file. The first line is a version string and should take the form:
# gene data version 1.0
[0052] The second line is a specification of column names in the form
# 'clone-id' 'gene-name' 'data-<col-num>-<name>' 'data-<col-num>-<name>' . . . 'data-<col-num>-<name>'
[0053] where 'clone-id' is the header for the clone id field and 'gene name' is the header for the gene name field. For example,
# clone-id gene-name data-1-UACC75 data-2-UACC89
[0054] The importer searches for a column named 'gene-name' and a column named 'clone-id'. It searches for data fields with names according to the convention 'data-<col-num>-<name>' (e.g., data-1-px1.1), where col-num specifies the column in which to display the data value.
[0055] Mismatched double quotes, single quotes, and extra ending whitespace are removed from names.
[0056] The GeneManager presents a table view of an item and its properties. FIG. 4, shows columns representing a CloneID, a Gene Name, and a set of data values, in this situation expression ratios represented by a color encoding which runs from green (highly down-regulated) to red (highly up-regulated). The table may be sorted, using the values of any column as the sort key, by clicking on the column heading.
[0057] In addition to providing ways to manually enter links to detailed data, the software can also semi-automatically populate items with links to detailed data. For example, knowledge discovery and data mining tools can be utilized to retrieve pertinent literature references and public database entries for an item. In this present embodiment, the software fills in, for each imported item, a URL for the LocusLink entry for that item.
[0058] When a new dataset is imported, the default operation is to add the new data to any existing data, so this may result in a duplication of items. The existing dataset may be cleared by selecting the File=>Delete my Gene Data & Exit menu item or by pressing the "nuke" button shown in the bottom-right of FIG. 1.
[0059] Often it is useful to group together "chunks" of related information, in order to build new abstractions or categories. For example, a set of genes known to influence muscle cell differentiation may be thought of together as a set. The program enables the investigator to group together "chunks" of related information via a construct known as collections. Collections are user-created, free-form sets of information. They can contain items and other collections.
[0060] Items are grouped into collections by dragging and dropping (or cutting/copying and pasting) items from the Gene Manager onto the desired collection in the Collection Manager. The Collection Manager component is a tree view of collections; it functions in a way that is analogous to the tree view of folders in Windows Explorer. FIG. 5 shows the Collection Manager. New collection are created by pressing th e right mouse button in th e Collection Manager, then selecting the New menu item shown in FIG. 6.
[0061] Collections can also be built semi-automatically. One mechanism is by searching on a biological term. This is done by selecting the Create Collection by Search submenu on the File menu. A dialogue box will pop up, in which the investigator can enter a biological term, for example "kinase", and a collection will be built consisting of items whose names have a match for that term.
[0062] Collections are very malleable: one can split and merge different collections, add items or groups of items, move items from one collection to another. Collections can be nested; a collection can contain other collections, as well as items. Collections can be overlaid with detailed experimental data, for example overlaying a set of expression levels on a collection of genes and highlighting those genes whose expression levels exceed a certain threshold. This is described in more detail in the section on semantic overlays.
[0063] Like items, collections can serve as repositories for links to detailed experimental data and public data, such as literature references. Web-based information on a gene may be moved into the collection representing that gene by dragging and dropping (or cutting/copying and pasting) text and URLs from a Web page (e.g. an NCBI Genbank entry for a gene) onto the appropriate collection in the collection manager shown in FIG. 4.
[0064] Along with the Gene Manager and Collection Manager, the present embodiment of the invention contains a GS Desktop pane, upon which items and collections of current interest can be dragged and dropped (or cut/copied and pasted). Dragging and dropping items and/or collections to this "desktop" pane creates a set of graphical "bookmarks." This is a convenient way to set aside a small "working set" of items and collections which may be the current focal point of investigation. The Desktop has the same drag/drop (and cut/copy/paste) semantics as other software components in the program. For example, dragging an item from the Gene Manager and dropping it onto a collection on the Desktop adds the item to that collection.
[0065] The next step in this process is the construction of biological stories, utilizing narrative structure to represent the state of the biologist's hypotheses and understandings. Narrative structure provides a framework for organizing information about the interrelationships and biological interactions amongst items and collections in biological pathways. Biological stories can be thought of as templates for organizing and describing what is going on in the cell. A biological story can also be thought of as the representation of a hypothesis and the train of thought that produced that hypothesis. The investigator can piece together knowledge about a biological phenomenon and compose a biological story by using the StoryEditor component shown in FIG. 8.
[0066] In the present invention, the narrative structure is organized around a story grammar, drawn from cognitive psychology research, and is shown in exemplary form in FIG. 9. Briefly, a Story consists of a Setting and a Plot and can also have a Theme. The Setting can contain a Location, a Time, and a set of Characters. The Plot can contain Events, Subplots, and Alternatives. Subplots and Alternatives can have a State associated with them. Events, Subplots, and Alternatives can all have justifications (either supporting or opposing) associated with them. Any of these story elements can take arbitrary annotations in the form of Comments. FIG. 10 shows an example story in XML form.
[0067] The StoryEditor component is a syntax-directed editor in which a biological story is represented by a tree structure. In this way, it is like an "outline processor". The tree appears on a canvas on the right side of the StoryEditor component. Descriptions of biological phenomena are added to this tree, with nodes that correspond to the elements of narrative structure, i.e. Characters, Events, etc. On the left side of the StoryEditor component is a set of buttons, which are used for adding nodes to (or deleting nodes from) the tree. At the bottom of the StoryEditor component is a text entry field, which is used to enter textual information associated with story nodes. Story nodes can be added to and deleted from the tree and textual descriptions can be added to story nodes in the tree. Each story node represents an element of narrative structure: for example a Character, Subplot, or Event.
[0068] A story node can be added by pressing a button in the StoryEditor component, for example pressing the Character button to add a Character to a Setting. For any story node in the story, there is a valid set of story nodes that can be nested below it. For example, it is valid to add an Event to a Plot but not to a Setting. When a story node is added, the buttons representing the valid story nodes that can be nested below it are enabled, whereas the non-valid story nodes are disabled (grayed out).
[0069] The investigator typically starts building up a biological story by specifying the Characters in the story. The Characters in a biological story can be either Items or Collections. Characters are added to a story by dragging and dropping (or cutting/copying and pasting) them from the Gene Manager and/or the Collection Manager. Characters can also be added by pressing the Character button and typing a name into the text entry field.
[0070] Other information pertinent to the Setting of a biological story can be added. Such information can include a Location, e.g. a differentiating muscle cell, or temporal information, e.g. during cell death.
[0071] The Setting for a biological story, including Characters, Location, and Time, captures the context of a biological story. The other main aspect of a biological story is the representation of the episodic flow of the biological story. This is represented by the Plot of the biological story.
[0072] In its simplest form, the Plot of a biological story represents a sequence of Events. The investigator creates Events by selecting the Event button in the StoryEditor component, which causes an Event node to be added to the biological story. The investigator then enters a textual description of the biological Event by typing into the text entry field of the StoryEditor shown as the bottom text field in FIG. 8.
[0073] Sometimes it is useful to group Events together and provide a name for that grouping. For example, in building up a biological story related to a signal transduction pathway, the investigator may want to create 3 groups of Events to represent Events that occur before, during, and after signaling, respectively. In this situation, a Subplot node may be added to the Plot of the biological story, and then a sequence of Events added to that Subplot.
[0074] Another common situation is where there may be more than one possible explanation, alternative hypotheses for what is going on. This is often the case in the early phases of investigation, where there often are several possible explanations for a phenomenon. The present invention enables the investigator to add and keep track of all of the alternative hypotheses, and to evolve them as the biologists=3 understanding is refined. To represent an alternative hypothesis, add an Alternative node to the Plot of the biological story, then add a sequence of Events to that Alternative.
[0075] Since the investigator typically will have assumptions or evidence underlying different hypotheses, it is useful to keep track of these assumptions and evidence. Using the present invention, the investigator can add a Support node to a Plot, Subplot, Alternative, or Event shown as the buttons on FIG. 8. Similarly, information that contradicts a hypothesis may be tracked. This is done by adding an Oppose node to a Plot, Subplot, Alternative, or Event. Textual information may be added to the Support and/or Oppose nodes by typing into the StoryEditor's text panel. Database and literature citations may be added to the Support and/or Oppose nodes by dragging and dropping a URL from a Web page onto a Support or Oppose node.
[0076] Using the StoryEditor component, the biologist can build up a structured textual representation of a biological story. Many people think graphically and often use sketches and diagrams to represent their thinking about an explanation they are piecing together. A biological pathway is a common way of representing a biological story pictorially. The present invention provides a PathwayEditor component, which is used to put together a biological story pictorially. An analogy can be drawn here to Computer-Aided Circuit Design (CAD) software, particularly to CAD schematic capture tools, in that the biologist uses the PathwayEditor to sketch out a representation of the "circuitry" of a biological pathway.
[0077] The PathwayEditor component consists of a canvas on the right and a set of buttons on the left for adding elements. In the PathwayEditor component, the investigator can put together diagrams representing the relationships between biological entities. These biological entities and their relationships can be thought of as the "nouns" and "verbs" of the biological story. In the present invention, the "nouns" are represented by items and collections. The pictorial story is built up by dragging/dropping items and/or collections onto the PathwayEditor panel. A graphical icon, representing the item or collection, appears at the drop point. There are a set of pre-defined "verbs" which are used to specify a relationship between "nouns", for example Inhibits, Promotes, or BindsTo.
[0078] Two "nouns" are connected with a "verb" by selecting the "verb" on the menu (e.g. by pressing a button labeled Promotes), then drawing a line between the two graphical icons representing the "nouns." Drawing is accomplished by positioning the mouse sprite over the first icon, pressing down on the mouse button, dragging the mouse sprite over to the second icon, then releasing the mouse button. A color-encoded arrow appears, connecting the two graphic icons, for example a red line represents the Inhibits "verb." "Verbs" in the PathwayEditor are directional; that is, a red arrow running from item A to item B indicates that "A Inhibits B," but not the converse.
[0079] There is a duality between graphical and textual storytelling. A textual story may be generated from the contents of the PathwayEditor component. The current invention includes a parser that recognizes "nouns" and "verbs" in the PathwayEditor and generates a textual biological story consisting of Characters (for "nouns") and Events (for "verbs"). The resulting text story is structurally equivalent to one that could have been entered via the StoryEditor.
[0080] Often it is useful to overlay items, collections, and biological stories with detailed experimental data, for example overlaying a set of expression levels on the Characters in a biological story and highlighting those genes whose expression levels exceed a certain threshold. This is analogous to the facilities in CAD tools for simulating circuit behavior; thus, the software provides a method for informally testing the hypotheses represented in biological stories. Such overlays are semantic, in that the meanings of the data, rather than their visual representations, are juxtaposed.
[0081] The present invention provides a method for constructing semantic overlays in the PathwayEditor component. If the items in the Gene Manager contain sets of expression levels from microarray experiments, then the biologist can "step through" each column of expression data and visualize the expression levels, color-coded on top of the icons for those items in the PathwayEditor. Such "simulations" can be useful, for example, in inferring relationships between items, such as causal relationships inferred by "stepping through" time course data.
[0082] The present invention uses generated Web pages to represent the detailed information contained in items and collections. The software generates an interlinked set 5 of Web pages, each item, each collection, and each element of a story having their own Web pages. When new information is associated with an item or collection, for example by dragging and dropping (or cutting/copying and pasting) a literature citation onto an item, that new information is incorporated into the Web page for that item. The investigator can navigate through this biological information space by selecting and following the links on the Web pages for items, collections, and stories. Such links are shown for example in FIG. 2. In addition to a specific Web page for each item, collection, and story node, there are index Web pages, one for the set of all items, one for the set of all collections, and one for the set of all story nodes shown in FIG. 7. A Web repository for a dataset is created by selecting the Publish To Web menu item on the File menu.
[0083] The program provides an ObjectEditor interface for editing and annotating the properties and contents of items and collections. The ObjectEditor tool is a form-based editor. By typing into fields in these forms, the biologist can add arbitrary annotations to the item or collection, as well as add annotations for each link to detailed information. For example, the biologist may want to add, as an annotation, a simple phrase that summarizes the main points of a literature citation.
[0084] While the program will be useful for an individual biologist in keeping track of information while building up explanations and hypotheses, some of its real power derives from the ability of the biologist to share biological stories with colleagues and collaborators. This is a way for the biologist to share the state of his/her thinking, receive feedback from colleagues, incorporate that feedback into the state of thinking, and, thus, refine the state of his/her thinking.
[0085] To support the sharing of biological stories, the present invention generates a Web page for every node that appears in the StoryEditor. Thus, every biological story can have its own Web page. The Characters displayed on the Web page for the biological story contain links to the Web pages for the items and collections represented by the Characters in the biological story. Thus, a person that visits the Web page for a biological story can navigate throughout the entire context surrounding that biological story. The Web page is a richly interconnected map of the biologist's train of thinking in building up a particular set of explanations and/or hypotheses.
[0086] If a colleague is using the program, rather than a Web browser, for viewing a biological story, then this colleague can serve as a "reviewer" and add annotations. This is done using the Comment node. The "reviewer" can add a Comment node to any node in a biological story, by pressing on the Comment button in the StoryEditor component and typing into the text panel of the StoryEditor component. The software tags such comments with the "reviewer's" name, so that annotations from different colleagues can be distinguished.
[0087] The state of work is saved by invoking the Save item on the File menu shown in FIG. 3. All items, collections, and stories are written to persistent storage, using XML Web technology described at [http://w3.org]. All the links to detailed information associated with the items, collections, and stories are saved along with them. Other contextual information, such as the coordinates of icons placed in the Desktop component, are also saved. All this information is restored the next time the program is run.
[0088] For safety purposes, the software will also prompt to save changes upon exiting the program. Invoking the Quit item on the File menu shown in FIG. 3 also causes the software to display a dialog box, asking to save changes.
[0089] The foregoing detailed description of the present invention is provided for the purpose of illustration and is not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Accordingly the scope of the present invention is defined by the appended claims.
|Zitiertes Patent
|4. Mai 1936
|28. März 1939
|American Box Board Co
|Titel nicht verfügbar
|Titel nicht verfügbar
|Titel nicht verfügbar
|Titel nicht verfügbar
|Zitiert von Patent
|23. Mai 2002
|6. Dez. 2005
|International Business Machines Corporation
|Preventing at least in part control processors from being overloaded
|22. Mai 2002
|6. Juni 2006
|Agilent Technologies, Inc.
|System, tools and methods to facilitate identification and organization of new information based on context of user's existing information
|22. Mai 2002
|26. Dez. 2006
|Agilent Technologies, Inc.
|Biotechnology information naming system
|30. Jan. 2003
|29. Mai 2007
|Agilent Technologies, Inc.
|Systems and methods for providing visualization and network diagrams
|14. Aug. 2003
|5. Juni 2007
|Agilent Technologies, Inc.
|System, tools and methods for viewing textual documents, extracting knowledge therefrom and converting the knowledge into other forms of representation of the knowledge
|21. Jan. 2003
|24. März 2009
|Microsoft Corporation
|Selection bins for browsing, annotating, sorting, clustering, and filtering media objects
|24. Juni 2005
|14. Apr. 2009
|Agilent Technologies, Inc.
|Systems, methods and computer readable media for performing a domain-specific metasearch, and visualizing search results therefrom
|20. März 2006
|2. Febr. 2010
|Microsoft Corporation
|Media frame object visualization system
|21. Mai 2010
|19. Aug. 2014
|Wendy Muzatko
|Story generation methods, story generation apparatuses, and articles of manufacture
|21. Jan. 2003
|22. Juli 2004
|Wong Curtis G.
|Selection bins
|30. Jan. 2003
|5. Aug. 2004
|Robert Kincaid
|Systems and methods for providing visualization and network diagrams
|21. Jan. 2003
|2. Sept. 2004
|Curtis G. Wong
|Rapid media group annotation
|14. Aug. 2003
|17. Febr. 2005
|Kuchinsky Allan J.
|Method and system for importing, creating and/or manipulating biological diagrams
|13. Mai 2004
|26. Mai 2005
|Gibb Sean G.
|Pipelined FFT processor with memory address interleaving
|20. März 2006
|20. Juli 2006
|Microsoft Corporation
|Media frame object visualization system
|Internationale Klassifikation
|Europäische Klassifikation
|8. Jan. 2002
Owner name: AGILENT TECHNOLOGIES, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KUCHINSKY, ALLAN;GRAHAM, KATHERINE;MOH, DAVID CHITAI;ANDOTHERS;REEL/FRAME:012284/0132
Effective date: 20011107


text:
Our group run/walk starts behind Run With It every Tuesday at 5:30PM. All ages and abilities are welcome at our very relaxed and non-competitive get together. There is water on the course at about the 5K turn around with refreshments and socializing at the store afterwards. It is a great way to get acquainted with the local running community and meet some cool, positive people! Hope to see you soon
5K from Run With It 5 mile from Run With It 10K from Run With It
5K Certified Course 10K Certified Course
Monday's run starts at Bric a Brac on Holiday Isle in Destin. On Thursdays the meet up is in the parking lot behind Alvin's Island on Okaloosa Island at 5:30 PM. Post run fun at Helen Back.
September 12 7:30am - Holy Day 5K, Miramar Beach
September 12 8:00am - One Run 5K, NW Florida State College, Niceville
September 19 7:30am - Sinfonia Bravo! Beat 5K Run/Walk, Village at Baytowne Wharf, Sandestin
September 19 7:30am - Lewis Middle School 5K, Valparaiso
September 26 7:30am - Ft. Walton Beach Cheerleaders 5K, Ft. Walton Beach
October 3 9:00am - Color Me Cured 5K/10K Fun Run, Ft. Walton Beach Landing
October 4 8:00am - Destin Rodeo Run, Destin
October 10 8am - Sons of Italy Festival 5K, Ft. Walton Beach
October 17 7:30am - Wicked Triple Fun Run 10K, Ft. Walton Beach Landing
October 17 5:30pm - Wicked Triple Fun Run 5K, Wyndham Gardens, Okaloosa Island
October 18 7:30am - Wicked Triple Fun Run Half Marathon, Ft. Walton Beach Landing
October 24 7:30am - Heroes and Villians 5K, Ft. Walton Beach Landing
October 31 9:00am - McGuires Halloween Run, Destin
November 7 8:00am - Veterans 5K, Destin
November 14 9:00am - Race for Lace 5K, Crestview
November 21 7:30am - Timberlake 5K and Half Marathon, Ft. Walton Beach
November 26 8:00am - Recycle Run 5k, Ft. Walton Beach Landing
December 5 7:30am - SFA Jingle Bell Jog, Okaloosa Island
December 19 8:30am - Egg Nog Jog, Ft. Walton Beach
December 31 5:30am - Round The Bay Ultra, Okaloosa Island and beyond
December 31 6:00pm - Blingin' In the New Year, Ft. Walton Beach Landing


text:
Bill Locey's concert picks: Donna Lynn Caskey at Ventura County's Agriculture Museum
If I had a faster car, a richer girlfriend or even one with a job, here's where I'd be lurking this week:
Subscribe to the Ventura County Star
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Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
Visit Edmunds.com for a complete listing of local car dealerships in Croton On Hudson, New York. Find the best deal on your next vehicle with online discount price quotes on car, truck, SUV, and minivan models. With the ability to compare prices on new and used vehicles in Croton On Hudson, Edmunds.com makes the car buying process convenient and cost-effective. Search for car dealerships in Croton On Hudson, New York with our comprehensive dealership network and avoid the common hassles associated with car shopping.
Non Display Review Name "I've known Jay M. for most of my life and he is so friendly and he's just an awesome human being!! He knows what he's talking about when it come to ca"... Read more Review by: mastermp23
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Non Display Review Name "Great Sales Team. Barbara and Franco delivered the car as promised and ensured that all of the details were addressed. I am thankful for their profe"... Read more Review by: matt04


text:
Repeat player WorkAudioBook
Sergey Povalyaev
- February 13, 2015
Offers in-app purchases
( 640)
WorkAudioBook is the best audiobook player / podcast player designed specifically FOR LANGUAGE LEARNERS who are listening English or ANY OTHER LANGUAGE. What it does:
-- Automatically splits audiobook into PHRASES;
All these features work with any MP3 file that you have in the memory of your device.
Full version -- $4.95 (in app menu choose Purchase), first two weeks are free of charge.
-- Automatically splits audiobook into PHRASES;
-- Can make AUTO-PAUSES between phrases;
-- Can AUTO-REPEAT phrases, files, folders;
-- Supports SUBTITLES and secondary subtitles and integration with many DICTIONARY apps;
-- Has NOTES for files and folders to put there text of your book or list of characters;
-- Supports BOOKMARKS with TAGS;
-- Supports HEADSET button;
-- Opens folders and supports PLAYLISTS;
-- Shows audio as a WAVEFORM and allows you to select and listen to any fragment and even an individual word;
-- REMEMBERS where you stopped and list of recent files.
All these features work with any MP3 file that you have in the memory of your device.
App works with files in ANY foreign language, not only English.
User interface is optimized for both PHONES and TABLETS.
Full version -- $4.95 (in app menu choose Purchase), first two weeks are free of charge.
There is also fully free version for Windows – http://www.workaudiobook.com
No ads. Learn a language with pleasure! :)
Write your opinion and suggestions to my E-MAIL – your responses are valuable for me!
You can listen and repeat audiobooks or podcasts in any of these foreign languages: English, French, Spanish, German, Russian, Mandarin, Chinese, Arabic, Portuguese, Japanese, and more! The app has "Download" functionality that allows you to download several popular classical English audiobooks from LibriVox, and train your English listening and speaking skills! With smart pause and AB repeat functionality you can improve your pronunciation and articulation easily!
Really like it but.... Just a couple of things. I want to buy this however can you let me know if you are still updating this app. It needs slower speed control and for longer MP3s a way to easily navigate back to the beginning, middle and end. Really enjoyed using it.
using it to learn Spanish And it works very well. Me gusta mucho
.lrc subtitles please plz plz make it support .lrc formats!
Love it But too expensive to buy TT. I wish i could use it free
!!!!Great!!!! The Best!!! I love this app.
I'd give 5 stars if this app controled play spead. 英語学習に使っています。音声ファイル内の音声の切れ目を自動的に判別し、切れ目間のセンテンスを繰り返し再生させることができます。再生スピードの調節ができれば星五つです。お金を出しても買うでしょう。
What's New
Version 4.2.1:
- "Find Text" command in Notes;
- Short press switches between Primary and Secondary subtitles in "Show Always" mode;
- Size of Subtitles and Notes window is increased for big phones and small tablets;
- Several bugs are fixed.
English in 7 Lessons for beginners. Only for RUSSIAN speakers!


text:
Campania Cast Stone Escala Garden Terrace Outdoor FountainItem # HN-CIB321
- Dimensions: 12.25W x 6.25H in, Weight: 38 lbs.
- Cast Stone construction
- Pump included
- Indoor and outdoor use
Recommended Accessories
Campania Cast Stone Sphere Garden Terrace Outdoor Fountain
Campania International Cast Stone Pebble Garden Terrace Outdoor Fountain
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Reviewed by 2 customers
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- Attractive Design
- Quiet Pump
- Splashes Over
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- Garden
- Home
Comments about Campania Cast Stone Escala Garden Terrace Outdoor Fountain:
This arrives in a HUGE box with a ridiculous amount of shredded, woody packaging. Like the reviewer noted below, the stuffing was a bit damp to the touch. I was nervous about this, but I think it's just intended to absorb moisture as the concrete dries, since these fountains are made to order.
The fountain arrived safe and sound, and I don't think the dampness of the straw is anything to be alarmed about.
Installation was a bit of a pain in the butt, but manageable with 2 people.
It looks great, I added some stones to the top basin.
The flow meter on the pump is VERY difficult to adjust to a nice middle setting. It's difficult to get the flow to a middle setting, because the slider is so sensitive. It's either FULL BORE, or barely a trickle. I've had to adjust it about 5 times, but I think I finally have it dialed.
NOTE: On the full setting this fountain DOES splash, and since I'm using this indoors, I needed to adjust the pump to a lower setting. It took about 3 days to get this perfectly dialed.
Comments about Campania Cast Stone Escala Garden Terrace Outdoor Fountain:
As I unpacked the box, the layers of straw became wetter and smellier. When I pulled out the first piece, the bottom was covered in wet mold which was by then all over my hand. I packed it right back up and got a return receipt. Fed Ex is scheduled to pick it up today.
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Customer Q & A
This product is handmade and painted. With that it takes time to put this product together. This is a special order meaning that it is not made until the order is placed.
That depends on where it is leaking from. Please check the rubber stopper and make sure it is in the correct place.
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text:
Dove Beauty Bar
916 reviews
87% would repurchase
Package Quality: 4.0
Price: $$
Package Quality: 4.0
Price: $$
INGREDIENTSsodium lauroyl isethionate, stearic acid, sodium tallowate or sodium palmitate, lauric acid, sodium isethionate, water, sodium stearate, cocamidopropyl betaine, sodium cocoate or sodium palm kernelate, fragrance, sodium chloride, tetrasodium edta, tetrasodium etidronate, titanium dioxide.
on 1/13/2008 4:59:00 PM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
I stopped using shower gels when I moved a few months ago and started buying the Dove beauty bar again. I really like the smell and it gets me clean without drying my skin. I am a huge fan of Dove's advertising campaign in which they use real women as models. I love the the fact they dont perpetuate the one size fits all standard of beauty. I know its an advertising campaign designed to make the company money but I cant help but support a company that shows how beautiful real women are. It feels good to buy from a company doing SOMETHING positive for women's self esteem plus the soap is great.
on 1/4/2008 12:13:00 AM
Age: 19-24
Skin: Acne-prone, Fair, Not Sure
Hair: Red, Other, Other
Eyes: Blue
Classic soap that cleans well and smells WONDERFUL. Brings back many memories of playing in the bathtub as a child. We ALWAYS had Dove soap in the bathroom growing up. Perfect to cleanse and soothe itchy wintertime (or anytime your skin is dry) skin.
on 1/3/2008 9:39:00 AM
Age: 30-35
Skin: Acne-prone, Fair, Not Sure
Hair: Brown, Other, Other
Eyes: Hazel
This is my HG of all soaps. First of all, the scent can not be beat. I use this in the shower and have even used it on my face from time to time with no problems. Actually, I have used Dove in moments of desperation on my face during stubborn breakouts, and I swear, they cleared up quicker.
on 1/1/2008 1:21:00 AM
Age: 19-24
Skin: Normal, Olive, Not Sure
Hair: Black, Other, Other
Eyes: Brown
i love dove soaps. my skin always feels beautifull moisturized, silky and soft after my shower.
on 12/25/2007 10:37:00 PM
Age: 19-24
Skin: Combination, Olive, Not Sure
Hair: Black, Wavy, Other
Eyes: Brown
I use this after I use dipilatory cream just to calm everything down. I never get irritated skin thanks to this fantastic classic soap. The scent is out of this world too. Nothing can compare.
on 12/22/2007 5:05:00 AM
Age: 56 & Over
Skin: Normal, Olive, Not Sure
Hair: Black, Other, Other
Eyes: Blue
This soap doesn't cleanse very well. It left me feeling filmy and greasy, and I ended up with some acne too. I guess it was moisturizing, but I can always use lotion for that, I want my soap to clean!
on 12/2/2007 10:59:00 AM
Age: 19-24
Skin: Combination, Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
This soap is good, I grew up using it. It lathers well and is moisturizing. However I don't like the fact that I run out of it so fast, 2 weeks. I'm going to be trying out more expensive soaps out now, I like nice bath products and that is one arena I have yet to explore.
on 11/28/2007 6:06:00 AM
Age: 19-24
Skin: Other, Other, Not Sure
Hair: Black, Other, Other
Eyes: Black
I love love love love the smell of this soap. I can't say it enough. I love showering because I love the rich lather and the way it rinses clean with just a hint of moisture.
I haven't used this on my face, I strictly use this on my body. I like to spray perfume on my skin right after I shower with Dove because the perfume smells so much better (if you like soapy scents, then this will work for you). I have also used perfumes I don't like as much over a Dove scented body and I swear I've decided to keep a lot of my old perfumes. continued >>
on 11/26/2007 11:09:00 PM
Age: 36-43
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Green
After years of searching for my HG cleanser and $$$ spent, I went back into my medicine cabinet and found this white bar of soap still in its box. I just love the smell of this soap and the way it makes my face feel so clean. I have been using this for a few months and still love it. I think this is the least expensive cleansing product I have purchased and the happiest I have been and my face is glowing! Try it.
on 11/20/2007 3:10:00 PM
Age: 25-29
Skin: Normal, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Hazel
Just keep coming back to this staple. This is one of the very few products that doesn't make my normal-combination skin freak out and go zitty. Smells good, feels good, and kills 2 birds with one stone as I can use it on both face and body. Yay!
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