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Systems genetics: From GWAS to disease pathways
ABSTRACT Most common diseases are complex, involving multiple genetic and environmental factors and their interactions. In the past decade, genome-wide association studies (GWAS) have successfully identified thousands of genetic variants underlying susceptibility to complex diseases. However, the results from these studies often do not provide evidence on how the variants affect downstream pathways and lead to the disease. Therefore, in the post-GWAS era the greatest challenge lies in combining GWAS findings with additional molecular data to functionally characterize the associations. The advances in various~omics techniques have made it possible to investigate the effect of risk variants on intermediate molecular levels, such as gene expression, methylation, protein abundance or metabolite levels. As disease aetiology is complex, no single molecular analysis is expected to fully unravel the disease mechanism. Multiple molecular levels can interact and also show plasticity in different physiological conditions, cell types and disease stages. There is therefore a great need for new integrative approaches that can combine data from different molecular levels and can help construct the causal inference from genotype to phenotype. Systems genetics is such an approach; it is used to study genetic effects within the larger scope of systems biology by integrating genotype information with various~omics datasets as well as with environmental and physiological variables. In this review, we describe this approach and discuss how it can help us unravel the molecular mechanisms through which genetic variation causes disease. This article is part of a Special Issue entitled: From Genome to Function.
Full-textDOI: · Available from: Jingyuan Fu, May 19, 2015
- SourceAvailable from: Stuart A Scott[Show abstract] [Hide abstract]
ABSTRACT: Clinical genetic testing began over 30 years ago with the availability of mutation detection for sickle cell disease diagnosis. Since then, the field has dramatically transformed to include gene sequencing, high-throughput targeted genotyping, prenatal mutation detection, preimplantation genetic diagnosis, population-based carrier screening, and now genome-wide analyses using microarrays and next-generation sequencing. Despite these significant advances in molecular technologies and testing capabilities, clinical genetics laboratories historically have been centered on mutation detection for Mendelian disorders. However, the ongoing identification of deoxyribonucleic acid (DNA) sequence variants associated with common diseases prompted the availability of testing for personal disease risk estimation, and created commercial opportunities for direct-to-consumer genetic testing companies that assay these variants. This germline genetic risk, in conjunction with other clinical, family, and demographic variables, are the key components of the personalized medicine paradigm, which aims to apply personal genomic and other relevant data into a patient's clinical assessment to more precisely guide medical management. However, genetic testing for disease risk estimation is an ongoing topic of debate, largely due to inconsistencies in the results, concerns over clinical validity and utility, and the variable mode of delivery when returning genetic results to patients in the absence of traditional counseling. A related class of genetic testing with analogous issues of clinical utility and acceptance is pharmacogenetic testing, which interrogates sequence variants implicated in interindividual drug response variability. Although clinical pharmacogenetic testing has not previously been widely adopted, advances in rapid turnaround time genetic testing technology and the recent implementation of preemptive genotyping programs at selected medical centers suggest that personalized medicine through pharmacogenetics is now a reality. This review aims to summarize the current state of implementing genetic testing for personalized medicine, with an emphasis on clinical pharmacogenetic testing.Pharmacogenomics and Personalized Medicine 08/2014; 7:227-40. DOI:10.2147/PGPM.S48887
Article: Disease pathways at the Rat Genome Database Pathway Portal: genes in context—a network approach to understanding the molecular mechanisms of disease[Show abstract] [Hide abstract]
ABSTRACT: Background Biological systems are exquisitely poised to respond and adjust to challenges, including damage. However, sustained damage can overcome the ability of the system to adjust and result in a disease phenotype, its underpinnings many times elusive. Unraveling the molecular mechanisms of systems biology, of how and why it falters, is essential for delineating the details of the path(s) leading to the diseased state and for designing strategies to revert its progression. An important aspect of this process is not only to define the function of a gene but to identify the context within which gene functions act. It is within the network, or pathway context, that the function of a gene fulfills its ultimate biological role. Resolving the extent to which defective function(s) affect the proceedings of pathway(s) and how altered pathways merge into overpowering the system¿s defense machinery are key to understanding the molecular aspects of disease and envisioning ways to counteract it. A network-centric approach to diseases is increasingly being considered in current research. It also underlies the deployment of disease pathways at the Rat Genome Database Pathway Portal. The portal is presented with an emphasis on disease and altered pathways, associated drug pathways, pathway suites, and suite networks.ResultsThe Pathway Portal at the Rat Genome Database (RGD) provides an ever-increasing collection of interactive pathway diagrams and associated annotations for metabolic, signaling, regulatory, and drug pathways, including disease and altered pathways. A disease pathway is viewed from the perspective of networks whose alterations are manifested in the affected phenotype. The Pathway Ontology (PW), built and maintained at RGD, facilitates the annotations of genes, the deployment of pathway diagrams, and provides an overall navigational tool. Pathways that revolve around a common concept and are globally connected are presented within pathway suites; a suite network combines two or more pathway suites.Conclusions The Pathway Portal is a rich resource that offers a range of pathway data and visualization, including disease pathways and related pathway suites. Viewing a disease pathway from the perspective of underlying altered pathways is an aid for dissecting the molecular mechanisms of disease.Human genomics 09/2014; 8(1):17. DOI:10.1186/PREACCEPT-2344511051385730 · 2.15 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Milani L, Leitsalu L, Metspalu A (University of Tartu). An epidemiological perspective of personalized medicine: the Estonian experience (Review). J Intern Med 2015; 277: 188–200. The Estonian Biobank and several other biobanks established over a decade ago are now starting to yield valuable longitudinal follow-up data for large numbers of individuals. These samples have been used in hundreds of different genome-wide association studies, resulting in the identification of reliable disease-associated variants. The focus of genomic research has started to shift from identifying genetic and nongenetic risk factors associated with common complex diseases to understanding the underlying mechanisms of the diseases and suggesting novel targets for therapy. However, translation of findings from genomic research into medical practice is still lagging, mainly due to insufficient evidence of clinical validity and utility. In this review, we examine the different elements required for the implementation of personalized medicine based on genomic information. First, biobanks and genome centres are required and have been established for the high-throughput genomic screening of large numbers of samples. Secondly, the combination of susceptibility alleles into polygenic risk scores has improved risk prediction of cardiovascular disease, breast cancer and several other diseases. Finally, national health information systems are being developed internationally, to combine data from electronic medical records from different sources, and also to gradually incorporate genomic information. We focus on the experience in Estonia, one of several countries with national goals towards more personalized health care based on genomic information, where the unique combination of elements required to accomplish this goal are already in place.Journal of Internal Medicine 10/2014; 277(2). DOI:10.1111/joim.12320 · 6.06 Impact Factor


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"You know, art can be something which can really disempower people, or it can be a vehicle which can empower people."
Production still from "Barry McGee: Tagging" (2013)
The mannequins—those tagging ones—have always been like illustrations to me, like of things that friends and I used to do when we were younger. Our situations we'd be in, like trying to get up higher and higher—getting on each other's shoulders."
—Barry McGee
WATCH: Barry McGee: Tagging

subset: commoncrawl


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You're invited to the wildest party around! Come celebrate your birthday at Safari Land. From the tiniest tiger to the eldest elephant, Safari Land will help you make your special day an adventure to remember!
PARTIES: enjoy a fully staffed, private, indoor party with giant interactive inflatable play structures and a 20' rock climbing...
Knockerbal ball is a spin on traditional soccer, players jump inside our inflatable suits which are designed to protect players...
Round up your family or your group and take a fall hayride to enjoy the fall colors and crisp autumn air. Bring your own food to cook over a bonfire or bring the fixings for s'mores. We provide hot chocolate and apple cider. Preregistration required.
Classes Guide - If you're looking for any type of classes, instruction or school for your child, this guide will help you out.
Limited Time Offer - $199 Parties for Monday - Thursday OR Limited Time Offer - $20 OFF any Saturday or Sunday party or $40 OFF any Monday through Friday party Don't miss out on these great offers!
We have been coming to this place for years and the extra bonus this year admission is FREE!!Sissy Taber
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Love Yu Kids Island! Both of my children had amazing birthday parties there! The staff is great and the party is be...Monika Rosol


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2017 Ford F-150 Raptor, Gran Turismo Supercars... Videos
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- Northern New York Newspapers
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NORFOLK Melinda S. Branham, 26, of 3755 State Route 310, Norfolk, who was charged by state police with third-degree assault, criminal mischief, three counts of criminal possession of a weapon and two counts of second-degree menacing Monday following two domestic incidents between Mrs. Branham and her husband, was arrested again for making a false statement to police.
Police said Mrs. Branham and her husband had an argument at their Norfolk home which led to her going after him with a drill. According to police, she than hit him with a baseball bat.
Police said later that day the two were traveling to Potsdam in a truck when they got into another argument, which led to Mrs. Branham stabbing her husband in the arm with a pocket knife, ripping his coat but not causing injury.
Mrs. Branham is scheduled to appear in Norfolk Town Court for the domestic incident.
Upon further investigation, police said, they found a statement Mrs. Branham made following her arrest Monday to be false. She is scheduled in Canton Town Court on that charge.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
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New Stanton Garden Inn
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Anticipating ......
In the final stages of planning our August 24 month long adventure in France. We will be landing in Paris at CDG airport on the morning of the 25th and trying to somehow find our way to the train station where we will get a train to Amiens - our first stop on our adventure.
Want to experience the adventure of traveling without preset places to stay, but geez luize it is kind of scary so am trying to put together a loose itinerary with lots of freedom built in - ...
It's August 7th, 24 days before we leave for France. It's our first trip as a family. Annie will be a little over 14 months old. I was kind of dreading the whole thing, how we will we do it, will Annie be a nightmare. I had a glimpse of what it could be several nights ago and my fears have been eased. The story goes we met down at the ballpark intending to walk home, met some people who offered us tickets. What to do? We have no bottle, one diaper, some wipes and ...
On the Road
... driving fast. The speed limit in Ohio is 70 and when Angela saw that she giggled like a child who was given ice cream for dinner. Usually we're in NYC traffic so she's stuck going slowly. How will she react when we get to a state where the speed limit is ...
New Stanton, PA./ Columbus OH.
... go for miles and miles.
The rural areas reflects prosperous living and the city of Columbus is so neat. Clean, tidy and easy to get around. Arena area would be so neat on a game night and the cities current development work on the riverfront show their progressive thoughts.
Unfortunately no home football game on whilst there as wanted to see the renown Ohio State University Band. Saw them on TV and put on an amazing show.
Day 8- Washington to Pittsburg.
... sandwich and their signature filling is fries and coleslaw in the sandwich. It was pretty good. Apparently it ranks number 3 in America's good eats. Also had a nice big beer with my dinner. Cause you can't go to a baseball game and not have beer. The hotel for the night was the Grand Wyndham the nicest one on the tour apparently. It was nice, bed were very ...


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Nissan 200SX Body Kits
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text: I am about to post 3 patches to clean up ccs a little bit in CVS HEAD. 001_ccs_clean_build_linking both libccs and daemon were building and linking common/log.c. Make libccs sucks in log.o and make ccsd link against libccs. Also fix ccs top level makefile to build in proper order. 002_ccs_daemon_cluster_base_on_ipv6 When the project switched away from magma, we forgot to enable IPv6 for cluster_base_port. The patch fix that and add some checks that were marked as TODO in the code. (NOTE: ccs_tools will require fix too, but i will do this tomorrow) 003_ccs_daemon_remove_dead_code pretty self explanatory, this code is not used anywhere. Get rid of it. Please apply or acknowledge and I will apply. Fabio -- I'm going to make him an offer he can't refuse.


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(April 20, 2010)--UTSA invites the academic community to attend "Admittance to Warn of Impending Heart Failure," a technical seminar featuring Marc David Feldman, M.D., professor of medicine and engineering in the Janey and Dolph Briscoe Division of Cardiology, University of Texas Health Science Center at San Antonio School of Medicine. The seminar sponsored by UTSA and UTHSC is 4 p.m., Wednesday, April 21 in the Biotechnology, Sciences and Engineering Building Multifunction Room (2.102) on the UTSA Main Campus.
Feldman's lecture will describe a new process that can be used to warn cardiologists that a patient is at risk for heart failure. In the heart, blood pressure-to-blood volume ratios are key in monitoring a patient's risk of heart failure. Measuring the real-time blood pressure in the heart's left ventricle is relatively easy. Measuring the real-time blood volume, however, is more problematic because blood seeps into the myocardium and artificially inflates volume measurements.
Feldman's team uses fixed stimulating and motion-sensing electrodes to obtain accurate real-time blood volume measurements. The researchers hope to broaden their approach by using moving motion-sensing electrodes that can be used as a heart failure warning system when they are piggybacked onto cardiac defibrillators and bi-ventricular pacemakers in patients with congestive heart failure.
A nationally recognized cardiovascular researcher, Feldman won the 2010 U.T. System Chancellor's Entrepreneurship and Innovation Award this month with his collaborator Tom Milner of the Department of Biomedical Engineering at UT Austin. The award honored the development of a novel cardiovascular imaging approach to assist cardiologists in better treating patients suffering from coronary artery disease. Feldman has obtained numerous patents for his inventions and launched two successful start-up companies.
Feldman earned his medical degree from the University of Pennsylvania in 1981, completed his internship and residency at the University of Chicago and went on to Harvard Medical School for a fellowship in cardiology.
The Seminars in Translational Research bring together investigators from basic, clinical and social sciences to highlight the bidirectional and multiple stages of the scientific translation of research discoveries, from the laboratory bench to the bedside and, ultimately, the community. Learn more about the lecture at the Seminars in Translational Research website.
The monthly seminars are sponsored by the UTSA Research Centers in Minority Institutions (RCMI), UTHSC Institute for Integration of Medicine and Science (IIMS) Novel Clinical and Translational Methodologies, and the Joint UTSA/UTHSC Graduate Program in Biomedical Engineering. RCMI and IIMS are supported by the National Center for Research Resources at the National Institutes of Health.
The UTSA College of Architecture, Construction and Planning, in partnership with AIA San Antonio's Latinos in Architecture, presents architect Andrés Jaque, founder of the Office for Political Innovation, an architectural practice dually based in New York and Madrid.
Buena Vista Building, Aula Canaria Lecture Hall (BV 1.328), Downtown Campus
The UTSA Women's Studies Institute invites you to Take Back the Night, an international initiative to raise awareness and empower survivors while educating allies through a march, poetry, and testimonios. This is a gender-inclusive movement to shatter the silence surrounding sexual and domestic violence.
Sombrilla Plaza, Main Campus
Grad Fest is an event designed to prepare you for commencement while celebrating your achievement. You will have the opportunity to purchase commencement regalia, order class rings, diploma frames, explore graduate school opportunities, learn about successful Stafford loan repayment and discuss career outcomes.
H-E-B University Center Ballroom, Main Campus
Grad Fest is an event designed to prepare you for commencement while celebrating your achievement. You will have the opportunity to purchase commencement regalia, order class rings, diploma frames, explore graduate school opportunities, learn about successful Stafford loan repayment and discuss career outcomes.
H-E-B University Center Ballroom, Main Campus
Looking for a good read? Shop for yourself or for gifts and help change a life at the same time. Browse and buy children's stories, novels and more at the 2015 SECC Book Sale.
Sombrilla Plaza, Main Campus
The Texas Water Symposium will take a close look at the SAWS/Vista Ridge pipeline project. The program will feature a conversation about the regional, financial and ecological considerations of the 142-mile pipeline. The event is free and open to the public.
Main Building (MB 0.106), Main Campus
What would Dr. John Bartkowski say if it were his last lecture? The UTSA professor of sociology will speak about "The Power of Listening" in this annual event sponsored by the UTSA chapter of Phi Kappa Phi. A reception will follow.
Denman Room (UC 2.201.28), Main Campus
The UTSA Music Department presents Emmy-award winning Composer Larry Groupe. Groupe has composed music for films such as "The Contender," "Straw Dogs" and "Miami Vice," and TV shows such as "Star Trek: The Next Generation," "Ren and Stimpy" and "American Gladiators." Lecture is free and open to the public.
Arts Building (ART 2.03.15-18), Main Campus
The Dean's Distinguished Lecture Series continues with Dr. Matthew Hughey, a scholar of race, racism and racial inequality.
Buena Vista Building (BV 1.328), Downtown Campus
Other Calendars
» UTSA Events | » Academic | » Institute of Texan Cultures
Performer, conductor will teach multidisciplinary courses in music marketing
As touch screens and e-books demand more and more attention from both casual readers and scholars, many people say the handwriting is on the wall for the printed page.
At UTSA, the handwriting is on the wall for a library that doesn't have any printed books.
Since March 2010, the bookless library in the Applied Engineering and Technology Building has given UTSA students an innovative way to read, research and work with each other to solve problems.
With ultra-modern furniture and a décor featuring desktop computers, scanners and LCD screens, the AET Library is designed to engage students in an online format. But it also offers group study niches and study rooms with whiteboards and glass walls on which students can write. The space encourages teamwork, communications and problem solving for the next generation of scientists and professional engineers.
Did you know? The UTSA AET Library is the nation's first completely bookless library on a college or university campus. It served as a model for Bexar County's first-in-the-nation public bookless library system and one of its branches, the Dr. Ricardo Romo BiblioTech.
The University of Texas at San Antonio is dedicated to the advancement of knowledge through research and discovery, teaching and learning, community engagement and public service. As an institution of access and excellence, UTSA embraces multicultural traditions and serves as a center for intellectual and creative resources as well as a catalyst for socioeconomic development and the commercialization of intellectual property - for Texas, the nation and the world.
To be a premier public research university, providing access to educational excellence and preparing citizen leaders for the global environment.
We encourage an environment of dialogue and discovery, where integrity, excellence, inclusiveness, respect, collaboration and innovation are fostered.


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The Average First-recurrence Time
University of California, Department of Mathematics, 1956 - Gases - 36 pages
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a a t(a admissible value argument assumed AVERAGE B,b)-1 We begin b2 To prove becomes begin with 11 bl b2 California Cartesian product completes the proof consecutive fractions Consequently consider constant contains covers the unit Cycle denominator denote the number dimensional equation 9 equation Xb evaluate exactly one solution fewer Fn_i follows fractions x/B gases help of Lemmas Hence i)da implies B>n-b>b+l induction inequalities initial inner sum interval I(a/b interval l(0/b length minimum molecules neighborhood neighbors number of integers number of prime pairs paradox PENNSYLVANIA STATE UNIVERSITY positive integer prime factors prime to n problem r+l b rational number a/b readily verified real number recurrence region defined Replace result Returning reversible satisfied smaller smallest positive value sum ranges ta-m theory unit interval UNIVERSITY LIBRARY write


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This new condom is all you need for Netflix and chilling
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There's a new sex toy for men, and it's called 'The Guybrator' (NSFW)
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Focus on Washington English Pleasure
English pleasure is a all-encompassing term for a number of different English riding classes seen at horse shows in the U.S., where the horse is ridden in either a hunt seat or saddle seat tack. A Hunt seat includes walk, trot, canter, and focuses on the horse's manners and way of going. Saddle seat is usually for flashy and gaited horses and shows off their high-stepping flair.
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Rustic Pines Farm - Boarding and training facility, 20 stalls indoor arena, trainer on site etc...
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Firecrest Santa Fe Alydar - Heterozygous Grey, very gentle and well mannered, and he throws some well put together foals...
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Iraq and Bowe Bergdahl
Should the US go back into Iraq? And what's next for Sgt. Bergdahl when he returns home?
Defense Secretary Faces Tough Questions on Capitol Hill
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Hagel to Lawmakers: Why We Didn't Tell You About Bergdahl
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CMO Zone: Related Articles
Visa: Going Global 'y' Local
Antonio J. Lucio, global chief marketing, strategy, and corporate development officer, Visa Inc., discussed how Visa is combining global and local strategies to achieve worldwide success.
Kimberly-Clark: Putting the Big "M" in Marketing
Anthony J. Palmer, senior vice president, chief marketing officer, Kimberly-Clark Corporation, discussed the four biggest marketing challenges that consumer products companies are facing today.
How to Make the Most Out of Your Ad Production Dollars
Jillian Gibbs, CEO and Founder, APR, discussed ways to boost the efficiency of marketing investments for ad production without sacrificing the quality of the creative.
Leadership Lessons
Find out what marketers can learn from former Campbell Soup CEO Doug Conant in a Q&A session with ANA Magazine. He discusses how he worked with the brand's marketing department, the average tenure of CMOs, and risk-taking in marketing.
The Future of Marketing
Eight visionaries reveal their predictions for the industry over the next decade. They discuss everything from social to mobile to search to online video.
Public Relations Firms Roundtable
Members of the Council of Public Relations Firms discussed issues related to PR agency compensation models, PR agency overhead, evaluating PR firms, social media, and how procurement and PR firms can better work together.
2011 Mobile Marketing Association CEO & CMO Summit Keynote
Jeffrey Hayzlett, former CMO and VP, Eastman Kodak Company, discussed why senior management should begin to embrace mobile.
Q&A with the CEO of Pandora
Greg Stuart, CEO, Mobile Marketing Association (MMA), interviewed Joe Kennedy, CEO and president, Pandora, during this session at the 2011 MMA CEO & CMO Summit.
2011 Mobile Marketing Association CEO & CMO Summit Keynote Address
Denny Strigl, former president and CEO, Verizon Wireless, and independent director, Kodak Eastman, discussed how companies can work to build awareness for new products.
Web Powered Retail: Serving Consumers Where We Find Them
Barry Judge, CMO, Best Buy, discussed how his organization interacts with consumers across multiple digital touch points.
12 Ways to Monetize Social Media
Paul Dunay, CMO, Networked Insights, shared 12 ways that marketers can measure social media ROI.
Measures for Success
Through focused efforts, brands in a number of industries are becoming more accountable marketing organizations. Learn what steps these companies are taking to improve marketing accountability.
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CMO Karen Quintos lays out a fresh branding campaign for courting IT success and provides best practices for achieving professional (and personal) victories.
The Changing Role of CMOs
Today's marketing leaders must create consistent, personalized customer experiences. CMOs from Procter & Gamble, Zappos, and Nike share how they connect with consumers.
Marketing Accountability: Earning a Seat at the Table
Containing data from ANA members such as Intel, CCP Games, and AB-InBev, this ANA Insight Brief touches on a variety of marketing accountability topics, including digital media metrics, how marketers can work better with finance, and improving marketing measurement.
The Future of Agency Relationships: Insight from Forrester
Chris Stutzman, Principal Analyst, Forrester Research, shared his thoughts on how client/agency relationships must evolve in the future.
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John Birmingham, chief marketing officer, DeVry University, and Kelly Twohig, executive vice president/digital managing director, Starcom USA, shared their best practices on developing successful integrated marketing programs and discussed how to get the most from your agency.
Taking Risks Together: True Partnership and the Return on Trust
Terri Graham, senior vice president and chief marketing officer, Jack in the Box, Inc., and Joanne O'Brien, group account director, Secret Weapon Marketing, discussed how transparency, mutual trust, commitment to partnership, and a willingness to take risks have contributed to their long-lasting client/agency relationship.
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Representatives from the 4As, the WPP Group, and TBWA Worldwide discussed the principles of fair agency compensation.
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Originally Posted by kb3lms
"Cold Case" is the program I think you mean. It's still on as reruns. You are right about the look although IDK if it was shot as digital. Whether digital or not, I think the look was intended to help communicate the cold, gritty atmosphere of Philidelphia, many areas of which I would describe as "cold."
IMDB says it was film:


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Asian markets rose on Wednesday, boosted by another record high for the Dow on Wall Street while concerns over the Cyprus bailout receded.
The euro edged down as dealers remain uneasy about the outlook for the wider eurozone in light of the Cyprus crisis while there is also ongoing political uncertainty in Italy.
Tokyo climbed 0.18 percent, or 22.17 points, to 12,493.79 and Sydney added 0.91 percent, or 44.8 points, to close at 4,995.0, while Seoul advanced 0.91 percent, or 9.74 points, to 1,993.44.
Hong Kong rose 0.69 percent, or 153.74 points, to 22,646.82 and Shanghai was up 0.16 percent, or 3.59 points, at 2,301.26.
Equity markets have stabilised since Nicosia agreed a last-minute deal with its international lenders that will see it receive a $13 billion rescue package to help pay its bills.
And while the decision to tax bank savings above 100,000 euros raised fears of a similar move in future rescues -- reinforced by comments from the head of the Eurogroup of finance ministers -- officials said Tuesday that Cyprus was a special case.
Wall Street provided the catalyst for buying as the Dow rose 0.77 percent to end at a new record, while the S&P 500 added 0.78 percent to close just two points shy of its own all-time high set in October 2007.
The tech-heavy Nasdaq Composite Index rose 17.18 (0.53 percent) to 3,252.48.
Tuesday's gains came on the back of data showing durable goods orders for February rose solidly, while the S&P/Case-Shiller Home Price index revealed an 8.1 percent rise in prices for 20 leading US cities for the 12 months to January, the highest year-on-year increase since mid-2006.
However, they were tempered by the Conference Board index of consumer confidence, which fell on concerns over swingeing federal budget cuts that kicked in on March 1.
On forex markets the dollar climbed to 94.62 yen from 94.55 yen in New York late Tuesday as eyes begin to turn to a Bank of Japan policy meeting next week that is expected to usher in fresh easing measures.
The meeting is the first under new governor Haruhiko Kuroda, who is a proponent of aggressive monetary policy to drag the country out of deflation.
The euro also climbed to 121.45 yen from 121.56 yen in New York but sat at $1.2843 compared with $1.2856.
The single currency still faces headwinds from lingering worries ahead of the opening Thursday of banks in Cyprus, which have been closed for almost two weeks.
On oil markets prices eased, with New York's main contract, light sweet crude for delivery in May, dropping 37 cents to $95.97 a barrel in the afternoon and Brent North Sea crude for May off 14 cents at $109.22.
Gold was at $1,594.10 an ounce at 0955 GMT compared with $1,596.20 late on Tuesday.
In other markets:
-- Manila rose 2.74 percent, adding 182.35 points to 6,847.47.
Traders welcomed a decision by Fitch to upgrade the country's credit rating to investment grade, citing the nation's resilient economy and improved fiscal management.
The move represents the first time one of the top three ratings agencies has graded the country so high.
"While some investors want at least two out of three major rating agencies to put a country at investment grade, this news will still make it easier for the market to reach 7,000," Luz Lorenzo of Maybank ATR-Kim Eng told Dow Jones Newswires.
BDO Unibank climbed 2.28 percent to 89.75 pesos, while Philippine Long Distance Telephone surged 4.18 percent to 2,988 pesos and Ayala Corp. added 1.34 percent to 566 pesos.
-- Singapore added 0.75 percent, or 24.50 points, to 3,313.03.
DBS Bank rose 1.46 percent to Sg$15.95 and Singapore Airlines was up 0.93 percent at Sg$10.90.
-- Taipei rose 0.48 percent, or 37.76 points, to 7,894.12.
Taiwan Semiconductor Manufacturing Company rose 1.52 percent to Tw$100.5 while Hon Hai was flat at Tw$83.5.
-- Wellington rose 1.52 percent, or 66.03 points, to 4,412.06.
Telecom rose 4.27 percent to NZ$2.32 and Fletcher Building was up 3.25 percent at NZ$8.58.
-- Jakarta added 1.77 percent, or 85.58 points, to end at 4,928.10.
Food manufacturer Cahaya Kalbar soared 12.67 percent to 1,690 rupiah and cigarette maker Hanjaya Mandala Sampoerna rose 3.13 percent to 82,500 rupiah, while polyester maker Indo-Rama Synthetics fell 8.16 percent to 1,350 rupiah.
-- Kuala Lumpur rose 0.89 percent, or 14.74 points, to 1,667.57.
CIMB Group Holdings climbed 4.5 percent to 7.69 ringgit, while Genting Malaysia was up 4.4 percent at 3.60 ringgit. Maxis shed 0.2 percent to 6.52 ringgit.
-- Bangkok added 1.09 percent, or 16.84 points, to 1,560.87.
Siam Cement jumped 5.53 percent to 496.00 baht, while Thai Airways rose 4.95 percent to 26.50 baht.
-- Mumbai was closed for a public holiday.


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Curt Schilling Shames Twitter Trolls Harassing His Daughter
We all know the good social media can do. Now, Curt Schilling is leading the charge to show the bad it can do.
We all know the good social media can do. Now, Curt Schilling is leading the charge to show the bad it can do.
Rock and Roll Hall of Famer Sir Elton John has carved out one of the most illustrious music careers of the past half-century.
He is the third most successful artist in the history of the American music charts, behind only Elvis Presley and The Beatles.
His home away from his United Kingdom home is Las Vegas, where he the resident artist at The Colosseum at Caesars Palace from March 18 to April 14. And you can win a trip to see him in concert there through 98.7 WFGR!
Severe bad weather caused The Eagles to briefly delay a concert in Australia on Saturday night.
A thunderstorm with 86-mile-per-hour winds hit near Australia's outdoor Hanging Rock venue in Victoria where the band was playing. The Eagles were in the middle of their third song when the stage began to shake, and a screen came loose and swung over the crowd.
They've gone from makeup to unmasked, hard rock to prog, and been one of the world's biggest rock bands for several decades, releasing a slew of classic studio and live LPs along the way.
Fleetwood Mac's 'Say You Love Me'
There are 24 hours in a day and not enough of them are dedicated to recharging our battery.
The NCAA has dropped the hammer on a player for doing something that seems incredibly necessary: he found somewhere to sleep.
Bryan Adams is hitting the road in April to celebrate the 30th anniversary of his iconic rock album, Reckless.
The tour kicks off on April 11 in Houston and includes a July 23 performance at DTE Energy Theatre in Clarkston.
Joey Logano charged out of a restart with three laps to go and drove to victory at the 2015 Daytona 500 at Daytona International Speedway in Florida on Sunday afternoon.
Being a parent means you're never off-duty while you make sure your kids are healthy and happy. But being a parent is also exhausting.
The New England Patriots last-second interception to seal their Super Bowl win was a strange way for a game to end, but it's got nothing on the finish in this youth league basketball game.


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|The Republic of South Sudan has become the world's newest nation by officially breaking away from Sudan after two civil wars and over five decades of conflict with the north. It is the 193rd country recognized by the UN.
A mood of joy and celebration swept through its capital Juba at midnight on Friday, with scenes of jubilation and sounds of church bells ringing.
Thousands of people gathered with friends and family on the streets singing, dancing, banging drums and honking horns in celebration.
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Party, Craft & School Supplies
Brainy Toys for Kids of All Ages
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If you have an upcoming event which you would like posted to our site, please contact us, providing date, location, contact information and any other pertinent details.
October 15, 2015
Shaunavon, SK
Learn how to troubleshoot your pasture pipeline, make economical decisions for providing power and understand regulations and permits for dugouts, dams and pipelines. This all-day event includes lunch and roast beef supper and two site visits. Cost is $35 for producers and $45 for industry. Contact Swift Current Creek Watershed Stewards at 306-770-4606 for the full agenda or to register. Please RSVP by October 12th.
November 17-19, 2015
Saskatoon, SK
The 6th Annual CFGA conference will highlight the profitability of intensive forage production systems and the potential of forages to provide ecosystem goods and services for all Canadians. Join us this November 17-19 in beautiful downtown Saskatoon at the Sheraton Cavalier Hotel for Canadian Forage in the International Year of Soils-Capture the Intensity!
November 25-27, 2015
Regina, SK
Farm Management Canada will host the Agricultural Excellence Conference (AgEx) in Regina this November. Running from noon to noon over three days, this conference cultivates the entrepreneurial farmer. The Canadian Western Agribition runs from Nov 23-28, 2015 so come early or stay late to take in both events!
December 8-10, 2015
Edmonton, AB
This upcoming conference will feature exciting keynote speakers Dr. Yamily Zavala, Dr. Harold van Es, Gabe Brown, Dr. Jill Clapperton and many more. Plan to attend this three day event at the Radisson Hotel Edmonton South to become more involved in the 2015 International Year of Soils!
January 20-22, 2016
Saskatoon, SK
Every farm and ranch is unique and holistic management enables you to deal with the uniqueness. Registration includes two coffee breaks, two evening meals and two lunches. Early registration cost is $185/person or $120 per student.
To find out more about the conference and registration, click here .
The 11th Prairie Conservation and Endangered Species Conference will be held February 16-18 in Saskatoon. The theme is Prairie-It's a Happening Place!
To find out more and receive updates, visit the website at www.pcesc.ca.
Save the date for this event taking place at Prairieland Park in March 2016. This two-day workshop will focus on the latest research in the field of agriculture on the first day and presentations focusing on pests and pulses to celebrate the 2016 International Year of the Pulse!
For more information, visit www.usask.ca/soilsncrops
The future management of grazing lands in a high-tech world. Plan to
join us! This all encompassing Congress will cover the Ecology,
Management and Policy issues of all types of grazing lands around the
To view this event flyer, click here.
For more information, go to www.irc2016canada.ca.


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Americas Best Value Inn - Gulfport
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- Continental Breakfast
- Free High-Speed Internet
- Swimming pool
- Wheelchair accessibility
- Free parking
- Pets allowed
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TripAdvisor Reviews Americas Best Value Inn - Gulfport
Travel Blogs from Gulfport
Leaving New Orleans and on to some Beachin fun
... hits of the 80's Radio" playlist ... Danger Zone, Rock You Like A Hurricane, Kim is driving as the sun sets as we pass the exit for Uriah and Atmore Alabama. next stop is Montgomery AL where we'll crash for the night before heading into the last leg of our trip back the ...
John C. Stennis Space Center
Today we stopped in Mississippi at the Stennis Space Center. This is a NASA test center where engines are test fired.
We saw where the Saturn 5 rockets, Shuttle and now the SLS engines are tested.
The Linear Aerospike Engine for the cancelled X-33 was also fired here.
It was worth the stop since it was on our way and a convenient stop. Doesn't really compare to Kennedy Space Center but it was interesting none the less.
Not much time in Biloxi
Staying at Martin Lake Resort which is a definite stretch! It is mobile home park not an rv park, with old fifth wheels and campers that people call home. There is a nice lake and a pool. We drove down along the gulf and stopped to take pictures of the carved trees damaged during Katrina. Absolutely beautiful! Had dinner at BBQ joint that had wonderful reviews but we didn't like it as much. However the owner was so friendly it made up for it. Leave tomorrow for ...
4 States in 1 day!!
January 5th we drove from Destin Florida to New Orleans, Louisiana, only 261 miles (417km) but it took us through 4 States in 1 day!! Starting in Florida we drive through Mobile, Alabama; Gulfport Mississippi; & finally to Kenner, New Orleans, Lousianna. We opted to the faster route on Highway 10 inland because the weathers not great, it's cool & ...
Hints on distance riding
... the extra effort required to support a helmet. Hand, wrist, and forearm pain - These areas can get sore on anyone, but sport bike riders often have the most difficulty because of the forward leaning body position. Long distance riders who do not use a throttle-locking device also have difficulty, as the hand muscles grow tired from long period of twisting the throttle. Hip pain - As you ride, you grip the seat and the tank with your hips. You also use the hips to help soften the ...


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The official thrift/discount store bragging thread - Page 4597
Styleforum Top Picks
- Frederique Constant Classic Chronograph Watch - FC-291MC2R6No reviews yet.
- Posts: 788
- Joined: 3/2013
- Location: Colorado, USA
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- Posts: 728
- Joined: 3/2012
- Location: Toronto
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And while we're on the subject of fit pics (are we even?), here's a rubbish elevator selfie from earlier today.
Jacket - Taylor Supply Co. grey herringbone Roosevelt - from Nat (thanks again!)
Shirt - BoO light blue/white stripe oxford - eThrift
Pants - Coppley grey single pleat - thrift
Shoes - AE Byron black oxfords - from hooker4186 (thanks again!)
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John Varvatos Parisian Chelsea Boots
Warning: Spoiler! (Click to show)
John Varvatos Fleetwood Boots ...missing laces, oh well
Warning: Spoiler! (Click to show)
Guess it makes up for the all day bust in LA yesterday...still looking for a couple places LA guys...it's not like I would be there every week....maybe just once every two or three months! I promise I wont take all the good stuff!
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the grey ones are nice!
I've flipped over hundreds (if not thousands) of lighters in the search for a Dunhill. This is the closest I've come.
Dunhill shell pipe:
Dunhill pipe reamer, in its original box/pouch:
Nice Persols....unfortunately prescription.
This was my first coffee/cake sitting outside this spring. I'm not normally in the habit of taking pictures of my food, but I originally took a picture to send to my wife to show her how bad the waiter was. We always roll our eyes when we see him at this cafe, and this time he set my cake, coffee and water at the end of the table next to me, on the opposite side. I had to get up, walk to the other side and bring it all over. #Firstworldproblems, right? Well it still annoys me as he expects a tip when he didn't even put a bit of care into a simple activity. /rant
Anyway, cake was good and I had missed sitting outside.
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Unfortunately I can't offer any info but it looks like a really cool shirt! Nice find!
So glad to see it worked for you! Looks like it fits great!
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Had time to make a quick run to two stores today.
FLorsheim Imperial PTB 10.5A Pebble - Available
AE 11 AA Wing Loafers Available
44L's get at me! Beautiful Vintage SC... 100% Cashmere. Available
Warning: Spoiler! (Click to show)
Real? Gucci thin almost see through cotton.
Orvis Yellow Sweater (Medium) and Shirt (XL) - Available
PRL Golf Thin Cotton Sweatervest
Couple squares and RT tie
PM sent for the plaid SC
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OK, I've picked up a handful of awesome thrift shop items, perhaps you can help me get some more. Here's the rub, I'm 6'5", so most thrift shops don't carry 44XL / 44L jackets or 17.5x37 shirts. Are there any stores or sites that cater to those of us who are taller than average?
Thanks, in advance, for the wonderful help!
The little one I painted a color called "deep forest pine" and the larger one will be a dark blue called "sailboat". I huge improvement, if I do say so myself.
I still need to remove the paint from the fittings and do some detailing on the black parts, but otherwise, one down and one to go.
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PARAGON Takes Shape
PARAGON Takes Shape
Jan 23, 2005 11:53AM PST
Isnt it pretty? ^__^
I made it last night as the first decoration for the frontpage of ParaRnM (we really need to work on a cool abreviation...). Anyway, the groundwork is being laid as we speak, so I'll keep ya posted as new junk comes to pass!
Comments (1)
Go Master Chief, Go!Posted: Feb 15, 2005 12:00AM PST by Mysterious_Vegetable
I love it! The best part is the Master Chief who is about to plug Sephiroth in the head for being so fruity.


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Vegan Ultramarathoner Breaks Appalachian Trail Record
Vegan ultramarathoner Scott Jurek broke the record on Sunday for fastest person to finish a supported thru-hike on the Appalachian Trail. Jurek finished the 2,189-mile hike in 46 days, 8
Trucker Loses 65 Pounds Thanks to New Vegan Diet
Long haul Mississippi trucker Bobby Anderson dropped 65 pounds after adopting a vegan diet, while on the road. Spending about 14 hours a day, six days a week, behind a
Pamela Anderson Launches 'Sensual Vegan' Cooking Show
Pamela Anderson has launched her very own online cooking show where she and her friend Delahna Flagg make easy vegan meals. "You only learn how to cook from your parents
Hugo Boss Bans Fur From All Upcoming Collections
As the fashion industry shows its lack of taste with a re-emergence of fur clothes, luxury fashion designer Hugo Boss has pledged to go fur free in all of its
Fur Is Making A Giant Comeback In the Fashion World
Well, this sucks. From the looks of the recent Paris runways, fur is definitely not going anywhere anytime soon. Fendi recently held a "haute fourrure" show last Wednesday, which was
Annie's Now Sells Vegan Mac And Cheese
There's never been a better time to be vegan! Just days after the largest ice cream maker in the United States announced it's testing four different flavors of non-dairy ice
Jessica Alba's Honest Company to Launch Beauty Line
Jessica Alba's huge eco-friendly empire is continue to grow in the fall with a cosmetics line. The actress turned green billionaire was one of the founders of The Honest Company


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Larian Motel Tombstone
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Historical Traveler Reviews Larian Motel Tombstone
Great time in Tombstone!
Took the advice of others on TripAdvisor, and was not disappointed. Great location, friendly and accommodating owner, clean, nice sized room. I would recommend the Larian to anyone staying in Tombstone.
The best place to stay in Tombstone
The Larian is my favourite place to stay in Tombstone.I've stayed in three different hotels in Tombstone over the years,and the Larian was the best suited for me.It is ideally located in that you are staying right in town and you can walk to local attractions.It's on Fremont St.which runs parallel to Allen St.the main street in town,where the saloons and shops are, so it also offers a quiet retreat,after a hard day touring of the shops and bars.
Gordon is a friendly host and his staff are very helpful,the rooms are clean,large and comfortable.I spent 2 months in the US this summer,and stayed at the Larian on three seperate occasions.It's the next best thing to home for me,while I'm staying in Tombstone.
The Only place to stay in Tombstone
If you are ever in Tombstone, the place you want to stay is the Larian Motel. I am a single woman who travels the world over and I have stayed in many fine establishments, but NEVER have I stayed in a CLEANER room in my life! Believe me, I'm a "princess" and I wont stay in ANY "icky" places! The motel is vintage in its design, and each room has a name from the history Tombstone. I stayed in the Clanton room. The room was SO clean, plenty of towels, coffeemaker, blow dryer,TONS of hot water and windows you can open for fresh air! The staff is excellent and attentive, but the best gem of all is the proprietor, Gordon Anderson. This is the heart and soul of this operation, and he is such a great guy! He will tell you what there is to do in town, where to eat, what to try. He rocks! Trust me, this is THE place to stay.
Great place to stay
good clean large rooms at a great rate. Management very good and helpful. Within a few minutes walk of all attractions, well above our expections.
No reason to stay anywhere else, period...!
Our ninth visit here in Tombstone, guess where we stayed again? The Larian motel is without question the best place to stay in Tombstone.
Large rooms, very clean & up to date. Coffe pot, mini fridge very comfortable beds and smoke free!
We arrived in july 2005, I made a mistake making our reservations, upon arrival I found out we were a day early. This is peak time here in Tombstone & we had no place to stay.
Of course Gordon (owner manager etc..) would not let us sleep in the car ..so to speak. Unfortunatly his motel was full, Gordon went out of his way and called his competitors until he got us a room for the night..now thats good service!!!!
Motel is walking distance to the OK Corral and all events, you can't go wrong with the LARIAN!
Great stay
We stayed for two nights and enjoyed ourselves from the time we arrived until we left. We stayed in "Doc Holidays" room and found it to be clean and tidy. Little disappointed that there was no fridge in the room to put drinks or food. We had a small child who was still bottle fed so I was unable to make the bottles up the night before I had to do it in the morning before we went out. Also no jug to make a "cuppa", they did have a coffee machine, so I just removed the coffee part and boiled the coffee pot that way. Overall, it was a great place to stay, owner was very accomodating and helpful. We would stay there again, it is so close to town and food venues. LOVED TOMBSTONE!
A great place to stay
Good, clean, comfortable rooms. Within walking distance to Allen Street, restaurants and other amenities. Would definitely stay here again. Loved the Motel and loved Tombstone.
Happy return
Like my 3 night visit in September 2002 my 2005 stay at the Larian Motel was met with a most obliging owner and staff, the room was always very very clean and well maintained. A great place to stay at like the Larian makes ones visit to such a town like Tombstone all the memorable.
What a Relief
Our Retired Army/Marine son called us and told us he had motel reservations inTombstone, AZ. so we could visit our grandkids. My husband and I looked at each other knowing full well our son squeezes every dollar till it screams. We had great apprehension when he told us the name of the motel and it wasn't anything familiar to us, but we left Phoenix for Tombstone, and prayed alot.
We pulled into this clean, campy little motel named the Larian. The place was tidy, clean on the exterior but the dreaded moment came when our son opened the door to "Our Room". My husband the "Inspector" walked in first, he was shocked, it was not only spotless, nicely furnished with soutwestern style furniture, but it was like new inside, non-smoking and fresh. The bed and bath linens were good quality with one of those small easy to use coffeepots to revive us in the a.m.; plus a little fridge for my water and fruit. We meant the owner, who was very cordial and we found he was raised in Tombstone and knew all the interesting places and information that we find is a real plus when traveling. The Larian Motel was located about 1/2 a block from the mainstreet of Tombstone and was quiet and friendly. This motel even had benches to sit and enjoy the people who stayed there, the owner had seemed to think of everything. We appreciated this small motels family feeling and the knowledge of this real Tombstonian. Our familys thanks for a great place to stay!!
Very Friendly
Pulled into the Larian on our Harley before they had a chance to clean the rooms but they allowed us to drop our luggage off in our room and start touring the town. Gave great information on where to eat and were truly interested in how we were enjoying our stay with them. Rooms were clean and comfortable. They were always busy but would stop what they were doing to give us information or directions.
TripAdvisor Reviews Larian Motel Tombstone
Travel Blogs from Tombstone
The Wild Wild West
Zach had a hankering to visit Tombstone, AZ. Unfortunately by the time we got there, most of the attractions were closed. We did grab a beer at Doc Holiday's bar and play some pool. Then we got a hotel in Deming. It was over 100 degrees out- way to hot to ...
Home again
it is about 80 miles from Alpine to Marenci and it took me 3 hours. Switch back city. I had to stop the car when I sneezed because I always close my eyes. Signs promised big horn sheep but all I saw were deer and cows. I made it to the end of rt 191 south. My part of Cochise county is very green I am glad to be ...
One last hoorah!
... to say we did it, but in the end are proud to say we are from Texas and love Katy! After all, it is the people around you and the foundation of God and Christ in your life that brings happiness. Be happy and content with what you have - that is the challenge for us all every day! Thank you all for joining us on this adventure! God Bless! Proverbs 22:6 - Train a child in the way he should go, and when he is old he will not turn from it. Go West Young ...
Back to the late 1800s
We spent the day in Tombstone,about 40 km away from our campground. To get to Tombstone we drove through an area of largetrees and shrubs. I thought we had driven out of the desert but I found out later that the area has artesian wells, a rarity here. So it was sort of like being in an oasis.
So anyway, we arrived in Tombstone. Walking down the main street it felt like being on the set of ...


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Landmark Chardonnay Sonoma County Overlook 1992
Region: USA » California » Sonoma Valley
Winery: Landmark Vineyards
Color: White
Varietal: Chardonnay
Landmark Vineyards:
Landmark Vineyards may have been founded in the Windsor area of Sonoma County in 1974, but its roots stretch all the way back to 1838 and America's heartland. It was in Grand Detour, Illinois of that year that John Deere invented the steel plow – an event that virtually revolutionized the business of agriculture. In 1989, John Deere's great great granddaughter, Damaris Deere Ford, following the... Read more
Landmark Vineyards may have been founded in the Windsor area of Sonoma County in 1974, but its roots stretch all the way back to 1838 and America's heartland. It was in Grand Detour, Illinois of that year that John Deere invented the steel plow – an event that virtually revolutionized the business of agriculture. In 1989, John Deere's great great granddaughter, Damaris Deere Ford, following the family tradition in agriculture, relocated Landmark Vineyards from Windsor, a town that was slowly being smothered by urban sprawl to a spectacular piece of land at the base of Sugarloaf Mountain in the Sonoma Valley. Damaris believed that Landmark could be a small jewel of a winery and built a Spanish mission style winery equipped with state-of-the-art winemaking equipment capable of producing 20,000 cases of wine per year. With the help of renowned Landscape architect, Morgan Wheelock, she developed the 20-acre site into a lush, gorgeously landscaped wine estate. Damaris convinced her son, Michael Deere Colhoun and his wife Mary to move from the east coast and join her as partners in the winery. Once settled, the Colhouns set in motion a plan that would truly make the winery a landmark. In 1993, they hired world-renowned consulting enologist Helen Turley to work with winemaker, Eric Stern. This collaboration led to some excellent winemaking. Under Eric's direction, Landmark's wines have consistently garnered rave reviews from the wine writers. Our signature wine, the Overlook Chardonnay, has appeared on The Wine Spectator Top 100 list 7 times since 1997. The names of Landmark's wines reflect their John Deere heritage. Landmark and Overlook were family homes. The Grand Detour Pinot Noir is named for the location of John Deere's blacksmithing shop in Illinois. And with a nod to the beginning of it all, the Syrah is aptly named "Steel Plow." Landmark's mission is "to make great wines that enhance the joy of life." Quality and flavor begin in the vineyards. In addition to the estate vineyard, Landmark sources grapes from a range of different vineyards and those selected are among the finest in the highly diverse microclimates of California's winegrowing regions. While the variation of the wines from vintage to vintage can be dramatic or subtle, the crafting of each year's wine is guided by a single overriding philosophy at Landmark: "less is more." According to Winemaker, Eric Stern, "The less the wine is manipulated, the more flavors and aromas remain to enjoy." Tasting Room Landmark's Tasting Room is located on the corner of Highway 12 and Adobe Canyon Road in Kenwood. The Tasting Room is open seven days a week and is closed only on major holidays. Hours of operation: 10:30 AM to 4:30 PM seven days a week. Read less
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03 October, 2015
State of Punjab
Case FIR No.88 dated 15.03.2015
Gulzaar Singh aged 38 years, son of Sarabjit Singh, resident of House no 42, Urban Estate, Nabha
U/s 420 IPC
P.S. Nabha, District Patiala
Date of Surrender/Arrest : 11/10/2013
Application for Bail U/S 439 CrPC
03 October, 2015 by Puneet Batish · 0
10 August, 2015
Accused charged with offence of cheating - Any previous acts of fraud committed by him would have no relevancy to the charge
Before :- S.R. Das, C.J.I., P.B. Gajendragadkar and K. Subba Rao, JJ.
Criminal Appeal No. 105 of 1956. D/d. 24.9.1959.
For the Appellant :- H.N. Sanyal, Additional Solicitor General of India, N.S. Bindra, Senior Advocate, M.S. Pandit and R.H. Dhebar, Advocates.
The State of Bombay - Appellant
Rusy Mistry and another - Respondents
For the Respondents :- A.S.R. Chari, Senior Advocate, K.R. Choudhury, Advocate.
K. Subba Rao, J. - This appeal by special leave filed by the State of Bombay is directed against the judgment of the High Court of Judicature at Bombay setting aside the convictions of the respondents
10 August, 2015 by Puneet Batish · 0
30 June, 2015
Accused convicted under Section 7 of Essential Commodities Act and sentenced to 1 year R.I. - Accused faced trial for 13 years - Sentence reduced to already undergone 25 days
Before :- Mohinder Pal, J.
Criminal Appeal No. 721-SB of 2000. D/d. 01.12.2010
For the Appellant :- Mr. Puneet Sharma, Advocate, Amicus Curiae.
Davinderjit Singh - Appellant
State of Punjab - Respondent
For the Respondent :- Mr. Ranbir Singh Rawat, Assistant Advocate General, Punjab.
Mohinder Pal, J. - This appeal is directed against the judgment of conviction and the sentence order dated 19.7.2000 passed by the learned Special Judge, Sangrur, convicting the appellant under Section
30 June, 2015 by Puneet Batish · 0
29 June, 2015
Recovery of opium from a servant which belonged to his master - Servant not guilty of offence under NDPS Act - Cannot be held that he was in conscious possession of contraband
Before :- Harjit Singh Bedi and Chandramauli Kr. Prasad, JJ.
Criminal Appeal Nos. 451-452 of 2005. D/d. 28.04.2011.
For the Appellants :- Sushil Kumar Jain, Puneet Jain, Nil Kumar Verma and Ms. Pratibha Jain, Advocates.
Ram Singh - Appellant
Central Bureau of Narcotics - Respondent
For the Respondents :- Ashok Kumar Srivastava and Ms. Sushma Suri, Advocates.
2. According to the prosecution a secret information led to recovery of 2.1 Kgms. of opium by PW.7,
29 June, 2015 by Puneet Batish · 0
28 June, 2015
Double murder - Offence proved by injured eyewitness supported by medical evidence - It is not fatal if motive is not proved
Before :- P. Sathasivam and H.L. Gokhale, JJ.
Cri. A. Nos. 552 to 554, 555 to 557 and 558 of 2003 D/d. 2.9.2011.
For the Appearing Parties :- S.R. Bajwa, Sr. Dr. Manish Singhvi, AAG. Puneet Jain, Ms. Pratibha Jain, Ms. Trishna Mohan, Vijay kumar, Milind Kumar, Ms. Aishwarya Bhati, Sangram Singh, Gp. Capt. Karan Singh Bhati, Karmendra Singh, Sushil Kumar Jain and Aruneshwar Gupta, Advocates.
State of Rajasthan - Appellant
Arjun Singh and others - Respondents
28 June, 2015 by Puneet Batish · 0
27 June, 2015
Bail - Section 307 IPC - Attempt to murder - Accused is in custody for last more than 11 months - No witness examined till date - Trial likely to take time - Injured is not an indoor patient - Bail granted
Before :- S.S. Saron, J.
Criminal Misc. No. M-374 of 2011. D/d. 1.4.2011.
For the Petitioner :- Mr. G.S. Bhatia, Advocate.
Manjinder Singh - Petitioner
State of Punjab - Respondent
For the Respondent-State :- Mr. T.S. Salana, Deputy Advocate General, Punjab.
For the Petitioner :- Mr. Puneet Sharma, Advocate.
2. The petitioner seeks regular bail in a case registered against him on 20.4.2010 for the offences
27 June, 2015 by Puneet Batish · 0
26 June, 2015
Summoning of a person as additional accused - Evidence created some suspicion against the persons summoned as accused - But suspicion is not sufficient that there is reasonable prospect of convicting them of the offence
Before :- K.T. Thomas and A.P. Misra, JJ.
Criminal Appeal No. 184 of 2000 (Arising out of S.L.P. (Crl.) No. 3780 of 1999). D/d. 17.2.2000
For the Appearing Parties :- M/s. R.N. Trivedi, Additional Solicitor General, Subhash Jha, Sanjay Mann, Ms. Sangeeta Kumar, Ajay K. Agarwala, Ms. Rekha Pandey, P. Parmeswaran, G.B. Sathe, S.V. Deshpande, Ashwini Garg and Ms. Sushma Suri, Advocates.
Michael Machado & Anr. - Appellants
Central Bureau of Investigation & Anr. - Respondents
26 June, 2015 by Puneet Batish · 0
24 June, 2015
Value of F.I.R. - FIR can only be used for corroborating or contradicting its maker when he appears in Court as a witness
Before :- A. Alagiriswami, I.D. Dua and C.A. Vaidialingam, JJ.
Criminal Appeal No. 281 of 1971. D/d. 13.12.1972.
For the Appellant :- S.K. Dholakia and R.C. Bhatia, Advocates.
Dharma Ram Bhagare - Appellant
State of Maharashtra - Respondent
For the Respondent :- H.R. Khanna and B.D. Sharma, Advocates.
24 June, 2015 by Puneet Batish · 0
23 June, 2015
Decree against firm - Liability of partners - Partner can contend that he was not partner of firm in question at relevant time or decree was collusive or fraudulent - When decree is found not to be so, every partner is bound by decree
Before :- Sharad Manohar, J.
Civil Revn. Appln. No. 326 of 1982. D/d. 29.9.1982.
For the Petitioner (absent) :- N.V. Adhia, Advocate.
Jayantilal Mohanlal - Petitioner
Narandas and Sons - Respondents
For the Respondent No. 1 :- M.A. Rane with A.M. Mody, Advocate.
Sharad Manohar, J. - This is a revision application filed by a retired partner of the firm against which firm money decree has been passed by the Court. After passing of the decree, the decree-holder wanted to execute the same against the petitioner on the ground that he was a partner of the
23 June, 2015 by Puneet Batish · 0
Partnership Act, 1032, Section 32(2) - 4th defendant retired from partnership in 1983 - Intimation sent to Bank regarding reconstitution of partnership - Bank accepting the same - Held that 4th defendant has been discharged from plaint liability to the Bank
Before :- S. Sankarasubban and R. Bhaskaran, JJ.
A.S. No. 72 of 1991. D/d. 5.2.2002.
For the Appellant :- P.K. Joseph, Meena Sreedhar A. and M.A. Felicia, Advocates.
George - Appellant
State Bank of Travancore - Respondent
For the Respondent :- V.R. Kesava Kaimal, C. Usha Kaimal and Mr. M.M. Madhu, Advocates.
by Puneet Batish · 0
22 June, 2015
Husband and wife living separately by mutual consent - Wife accepting alimony of Rs. 20,000/- - Wife not entitled to maintenance
Before :- J.G. Chitre, J.
Cri. W.P. No. 1581 of 1999. D/d. 14.2.2003.
For the Petitioner :- Mrs. Anil Agarwal, Advocate.
Vitthal Hiraji Jadhav - Petitioner
Harnabai Vitthal Jadhav and another - Respondents
For the Respondent No. 1 :- None.
For the Respondent No. 2 :- Mr. K.V. Saste, A.P.P.
22 June, 2015 by Puneet Batish · 0
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text:
There is a growing feeling that if Newcastle lose to Swansea City on Saturday – a team that is fighting against relegation and are only 3 points above the drop zone – and suffer five defeats on the trot, that could well see owner Mike Ashley fire Alan Pardew, the Newcastle manager.
Alan Pardew on Saturday at Stoke
Of course it would take some gumption for the Newcastle owner to fire his manager after he has been part of the problem.
Ashley sold our best player in January – Yohan Cabaye for £20M to PSG – and then he didn't replace him, and in one move for big money three months ago – it weakened the Newcastle side big time.
Newcastle have missed Yohan Cabaye's goals – he had scored five in his last seven games for Newcastle – and his creative play has also been a big miss – and we wont even mention his threat from free-kicks.
And then early in March to compound things, we lost Loic Remy and Mathieu Debuchy to injury, and they haven't played since, and we have had five defeats in the last six games, and have scored one goal.
And it's certainly true that for one reason or another Alan Pardew is not getting the best out of the players he has available.
If he is, then the players need to be sold in the summer, because they are patently not good enough to wear the back and white shirt of Newcastle United.
So even if we are hopeless again on Saturday and heaven forbid we lose for the fourth successive time to Swansea, we still don't think Mike Ashley will sack the manager.
But you never know what Mike Ashley may do, and you never know what Ashley is thinking – maybe he's going to sell the club in the summer.
OK – so I just made that one up – bet that got your attention. 😀
If Pardew is fired before the summer transfer window rolls around, Wigan's new German manager Uwe Rosler, or former Chelsea and West Brom manager Roberto di Matteo would likely be strong candidates for the job.
But if there is going to be a change of manager, it would need to take place before the summer transfer season starts, because the manager needs to have input into that process.
We still think the chances are that Alan Pardew will be the manager come pre-season training in July – unless we lose the last four games of the season.
The Newcastle players need to go all out – 100% on Saturday – to try to get a second win in seven games.
What do you think?
Comments welcome.


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i stopped waxing due to ingrown hairs on my legs 6 years ago. I started tweezing ( 3 types of tweezers) & lifting the ingrowns with fine sewing needle. Before long I developed the habit of removing all hairs this way - at least 60%of the hairs were ingrown. Trouble is, I started digging too early.0 replies 0 votes Reply to fran 14997
Can you help? Discussions needing a reply
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Boils and acne
I have been an Acne sufferer since being a teen and had a course of Roacutane which cleared it for about 2 years but it has come back in 2014 I have now developed boils and had 10 in 8 months My children have also had boils several in a short space of time I took them to the Dr's but he seemed0 replies 0 votes Reply to vanilla7986
Lump in palm
I have a small lump in the palm of my hand. It is not painful just a bit annoying. Has anyone got a diagnosis for this0 replies 0 votes Reply to naji
All discussions in this group
reacurring boils
Hello, i have been getting boils in my groin area and thighs for about 4 years now. i have gone to my dr many many times. I have had blood tests to rule out diabeties. they have never taken a swap from me even when i have gone with boils in full swing but nothing is done. They now say there is7 replies 0 votes
I appear to have pseudo folliculitis on my legs
i stopped waxing due to ingrown hairs on my legs 6 years ago. I started tweezing ( 3 types of tweezers) & lifting the ingrowns with fine sewing needle. Before long I developed the habit of removing all hairs this way - at least 60%of the hairs were ingrown. Trouble is, I started digging too early.0 replies 0 votes
Boils and acne
I have been an Acne sufferer since being a teen and had a course of Roacutane which cleared it for about 2 years but it has come back in 2014 I have now developed boils and had 10 in 8 months My children have also had boils several in a short space of time I took them to the Dr's but he seemed0 replies 0 votes
Lump in palm
Been told by dermatologist to take rouacotaine
Not sure if I've spelt this correctly-rouacoutaine? I've had follicultitis for many years & nothing has worked. I'm 65 reasonably healthy. Recently the medication given to me made the condition worse. Now I've been advise to take this & been told about the effects I may have & also that it may0 replies 0 votes
scalp folliculitis
I have had this condition for a few years & tried most treatments with little success. in the last couple of weeks i have tried putting a little anti bacterial gel on moist hands & rubbing them on my scalp, for whatever reason it seems to be helping,whether it is a coincidence i dont know but i am2 replies 0 votes
Boils, Abcesses, Use this remedy !!!
Hi, I think It's to do with diet, stress, dehydration, then again my kid has got a few maybe from me ??? I'm 35 and got one on back of my neck then a few on my chest and backside very very painfull. The one on back of my neck I had to have a opp at hospital. On the others I used Turmeric,0 replies 0 votes
Boils, lots of them. Dermatologist wants to give me Roacctune? :/
I've been getting boils on my face, back and front of neck, my back and my bottom for a while now, they weren't too bad before and a round of antibiotics a year ago from the doctor helped temporarily. Recently I've been getting more, I feel like when I'm stressed/run down they get a lot worse! I'1 reply 0 votes
Folliculitis for over a year
I have had folliculitis for over a year. I get these bumps under my skin on the topside of my arms by the elbow area that eventually turn to whiteheads. They are scarring my arms all up. My Doc gave me Azithromycin for 3 months and it seemed to clear it up, but as soon as I stopped the1 reply 0 votes
i need help as things are getting out of hand?
HI I'm 19 year old male who has been suffering from folliculitus since the age of 10. It's plagued my teen years and it's and issue that needs to be ridden off. I have been on anti biotics to get rid of the 'spots' and used various creams. My hair is very dry and the scalp is worse. I know this is3 replies 0 votes
Boils underarm
hi there my partner has theses under her arms,she's had them 12months now they come for a week then go for a few days the doctor are useless all Iv ever been told is try theses antibiotics then come see me then two weeks down the line when she's still got them they Palm her off with differ ones as0 replies 0 votes
hi. . right now im suffering from boil. . and its really painful. .i was not able to go to work because of the pain. . i think this is chronic furunculosis. .i dnt know what to do anymore it keeps comin back. .at my thighs, neck, armpit my back. . i hope i can find a treatment for this chronic skin4 replies 0 votes
All I have gained as experience
It looks like the bugs(bacteria virus or fungi) seem to overgrow in some individuals more than others on some surfaces. like for me in the scalp neck axilla causing folliculitis. Questions I am trying to find answers what is the factor that favours their growth? What is that causes them to1 reply 0 votes
i have severe folliculitis
Hair removal for Folliculitis?
Hi. Does anyone know if hair removal is available on nhs for Folliculitis? Suffered with with this for nearly 3 years and nothing works. Suffer with it on my genital area which is now spreading to my inner thigh. Ive been prescribed washes which dont seem to help and umpteen amounts of antibiotics.5 replies 0 votes
my "solution" for foliculitis
I've had this foliculitis thing going for the better part of a year. Painful irritated pimple-like bumps and clusters all over my thighs, butt, back, shoulders. Normally they just flare up and die down. But sometimes they form white heads, pop, bleed, ooze, or become infected staph cysts that get3 replies 1 vote
I've recently changed antibiotics!
I've had a very bad bout of follicullitis recently and have changed from eruthromycin to clarythromycin on the advice of my doctor. I also use the cream methromyzadol. I thought the pustules were drying up but because I haven't been able to get another prescription for the cream I've been unable4 replies 0 votes
Try this--it worked for me
I started getting folliculitis 2 yrs ago. It got to the point where it was so bad it was seriously painful. I took doxycycline orally for 1 year and topical clyndamycin for 1.5 years Eventually the doxycycline was too much and it started giving me dermatographism, so I had to stop. I was also1 reply 0 votes
I just want to share my turmoil with other sufferers. i have suffered from this n my scalp for over 5 years. iv seen a specialist privately 2 yrs ago as it got so bad and depressing. i was perscribed capsol shampoo, bacroban ointment and mynocylin antbiotics ive been using all 3 ever since to no2 replies 0 votes
My carbuncle experience
Recently i can say that i had the unfortunate encounter of a carbuncle my chin! This apparently is unheard of, as usually it occurs on the back of the neck or on the thighs. Mine began as a tiny spot (just like any other normal spot) then as the days went on it began to grow larger. It1 reply 0 votes
nothing seems to help
im a 24 year old woman. ive suffered with folliculitis for nearly 3 years now, it started on my back and shoulders it took countless trips to the doctor to find out what this itchy rash was only to be fobbed off with creams and tablets, only after 2 years suffering was i reffered to a specialist1 reply 0 votes
Recurring boils - how to prevent them?
Hi there, About 5 years ago I got my first boil (on my hip) and until this summer I hadn't had any further problems. In July, on the site of the initial boil, another one formed. I was in agony for 2-3 weeks and it was a full time job tending to it (salt baths, heat packs, magnesium paste etc).1 reply 0 votes
sufferer of boils
hi im 18 years old and suffer terribly from boils. ive only recently started having boils over the last few months but ive had about several boils. the first one i ever got was a minor one, at first we thought it was an infection from my tattoo but id had that for ages then the doctor told me it1 reply 0 votes
I have had what has been called many different medical n...
I have had what has been called many different medical names since I was 17 years old. I am now 58, and continue to be tortured from the boils, carbuncles, etc. My problems began after I had surgery for a pilondial cyst (this cyst is caused from an ingrown hair, and it is always located at the2 replies 0 votes
Follicultis in my entire life
I have this problem on my body (arms, legs, back) which most have small bumps. It is not reddish but just a small-like pimple but no puss. Someone can only notice it on a closer look but I still not comfortable wearing mini skirts or sleeveless because the appearance of the bumps just so0 replies 0 votes
Folliculitis when waxing
I have experienced a break-out of folliculitis three times. I had been waxing for years on my legs when out of the blue I reacted badly and had to go on a course of anti-biotics. I lay off it for a good while but couldn't stand the shaving - yuck! I have always gone to a reputable beautician and0 replies 0 votes
For all of you suffering from folliculitis may I say I had this for over a year. I STUPIDLY used my recently oiled clippers to trim my pubic hair. The oil blocked the follicules (unbeknown to me) and I went through 6 different creams, fucibet, fuci something else etc eventually ended up1 reply 0 votes
thanks to everyone for sharing their experiences i thou...
thanks to everyone for sharing their experiences i thought it was just me that suffered in this way , well ive had follicilitus of the genital area for 2 years now and its awful , lare red boil type things appear on my vulva and inside my vagina and all around them areas , somedays i can hardly1 reply 0 votes
recurrent folliculitis
this is a very painful infection, i have had it recurring for over a year. i am now forced to wear wigs because of the scabs on and sensitivty of my scalp. it sucks having to wash my pillow cases almost everyday because of pus and blood stain on my pillows. my doctor has me on my second round of0 replies 0 votes
boils are painfull
i have sufferd from boills i do have a low white cell count it takes them longer to heal they are painfull can last up to 2 weeks without bursting the doctor gives me anti biotics but it comes back 2 weeks later i cant shave because i get 4 or 5 if i do i cant sit down somebody help0 replies 0 votes
I have had Boils from the age of 13 and I am now 42
The first Boil i got was on my bottom and i had salt bath's until it healed. When i was 15 i had another one and began the salt bath's again, but this time i did'nt get a head on it. It turned out it was blind and had to be operated on, they left the wound opened and packed it every day with what i1 reply 0 votes
I recently was diagosed with this rash, I had painful puss like blisters all on the trunk region of my body on the legs as well, painful. I went to the ER to make sure I was not contagious as I work with the elderly and did not want to infect anyone while working. I thought it was chicken pocs,0 replies 0 votes
:cry: my son who is 11 years old has suffered from carbuncles since he was 18 months old his had blood tests and theyve come back normal once again he has another carbuncle on his thigh im at my wits end his in a lot of pain and no one seems to know why he is getting them i need a second appion.0 replies 0 votes
Deep carbuncle developed over months, drained, re-occured
While showering, I noticed a deep lump about two inches from my anus. It grew from pea size to the diameter of a nickel over a period of about five months. I never experienced any pain. My doctor lanced it, drained the pus, and I am developing another after three years. Any ideas, comments?0 replies 0 votes
Since visiting the doctor about my facial acne in July I now have foliculitis. This was caused by a reaction to the oxyteracycline that I was given My back and chest are covered and i have been back seveal times and been given varioous creams and also eurithromiacine whi ch iwas on in my mid 20's.0 replies 0 votes
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this is honestly my first time doing this. my friends have read my things and i want to show them to everyone else. i just hope i dont get any bad things about the things that i write!! :( I'm going to keep writting no matter what! :) I love you guys though. ❤
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Catherine - Duchess of Cambridge
Tourists look at an information sign outside Buckingham Palace in... News PhotoArts Culture and Entertainment,British Royalty,Buckingham Palace,Catherine - Duchess of Cambridge,Celebrities,Dress,Duchess,Duke,Greater London,Highlights,Horizontal,International Landmark,London - England,Married,Old,Prince - Royal Person,Prince William,Royal Wedding,Royalty,Summer,Tourism,Tourist,UKPhotographer CARL COURTCollection: AFP 2011 AFPTourists look at an information sign outside Buckingham Palace in central London as the palace opens its doors to the public for the summer on July 23, 2011, to showcase highlights including the dress worn by Kate Middleton when she married Prince William in April. It was the best kept secret of the royal wedding, but now the Alexander McQueen dress worn by the former Kate Middleton when she married Prince William is being put on public display for all to admire. Catherine's ivory and white satin-gazar dress, designed by Sarah Burton, goes on show at Buckingham Palace on Saturday as part of the annual summer opening, where hundreds of thousands of visitors are expected to flock to see it. AFP PHOTO / CARL COURT (Photo credit should read CARL COURT/AFP/Getty Images)