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Pleuritis due to Brevundimonas diminuta in a previously healthy man.
Lu, Binghuai; Shi, Yanli; Zhu, Fengxia; Xu, Xiaolin
Brevundimonas diminuta is rarely associated with invasive infections. We report the case of a previously healthy young man with pleural effusion, in which B. diminuta was recovered but incorrectly identified as Kingella kingae when it was freshly isolated. Consequently, the misidentification resulted in initial treatment failure. The correct identification was achieved through further incubation, sequencing of the 16S rRNA gene and MS. PMID:23180480
17 CFR 46.11 - Reporting of errors and omissions in previously reported data.
Code of Federal Regulations, 2013 CFR
...errors and omissions in previously reported data. 46.11 Section 46.11 Commodity...COMMODITY FUTURES TRADING COMMISSION SWAP DATA RECORDKEEPING AND REPORTING REQUIREMENTS...errors and omissions in previously reported data. (a) Each swap counterparty...
17 CFR 46.11 - Reporting of errors and omissions in previously reported data.
Code of Federal Regulations, 2014 CFR
...errors and omissions in previously reported data. 46.11 Section 46.11 Commodity...TRADING COMMISSION (CONTINUED) SWAP DATA RECORDKEEPING AND REPORTING REQUIREMENTS...errors and omissions in previously reported data. (a) Each swap counterparty...
17 CFR 45.14 - Reporting of errors and omissions in previously reported data.
Code of Federal Regulations, 2013 CFR
...errors and omissions in previously reported data. 45.14 Section 45.14 Commodity...COMMODITY FUTURES TRADING COMMISSION SWAP DATA RECORDKEEPING AND REPORTING REQUIREMENTS...errors and omissions in previously reported data. (a) Each registered entity and...
17 CFR 45.14 - Reporting of errors and omissions in previously reported data.
Code of Federal Regulations, 2014 CFR
...errors and omissions in previously reported data. 45.14 Section 45.14 Commodity...TRADING COMMISSION (CONTINUED) SWAP DATA RECORDKEEPING AND REPORTING REQUIREMENTS...errors and omissions in previously reported data. (a) Each registered entity and...
17 CFR 45.14 - Reporting of errors and omissions in previously reported data.
Code of Federal Regulations, 2012 CFR
...errors and omissions in previously reported data. 45.14 Section 45.14 Commodity...COMMODITY FUTURES TRADING COMMISSION SWAP DATA RECORDKEEPING AND REPORTING REQUIREMENTS...errors and omissions in previously reported data. (a) Each registered entity and...
Community Acquired Chronic Arthritis due to Pseudomonas aeruginosa in a Previously Healthy Pregnant Woman
Yilmaz, Mesut; Arslan, Ferhat; Mert, Ali
Septic arthritis caused by Pseudomonas aeruginosa is uncommon in the immunocompetent population, despite its occurrence in younger patients with open injuries and in intravenous drug abusers. Here we report a case of septic arthritis caused by P. aeruginosa. This case is unique for several reasons. First, it is a case of septic arthritis in a pregnant woman with no traditional risk factors reported in the literature including history of prior traumatic events, hospitalisation, or chronic underlying disease. She was suspected of having transient osteoporosis associated with pregnancy to involve both hip joints. Second, this is the first reported case of a community acquired chronic septic arthritis due to P. aeruginosa involving large joints of both upper and lower extremities. The patient was treated successfully with a combination of ceftazidime and amikacin for 4 weeks followed by oral ciprofloxacin 750?mg twice daily for 8 weeks. PMID:25371836
BRIEF REPORT Attention to Emotional Images in Previously Depressed
Habib, Ayman
. Consistent with previous studies (Kellough et al. in Behav Res Therapy 46:1238Ł1243, 2008; Sears et al Introduction Much of the research examining cognition in depression has been motivated by cognitive schema
Amnioinfusion in women with previous cesarean births: A preliminary report
Joseph G. Ouzounian; David A. Miller; Richard H. Paul
OBJECTIVE: Our purpose was to evaluate the use of intrapartum amnioinfusion in women undergoing a trial of labor after a previous cesarean delivery. STUDY DESIGN: Labor and delivery records of women undergoing intrapartum amnioinfusion over a 1-year period were reviewed retrospectively. Neonatal data were obtained by chart review. RESULTS: During the study period 936 women underwent intrapartum amnioinfusion for the
Due Date Report(s) Due Oct 15, 2013 FY 12-13 Audited Financial Statements
Meyers, Steven D.
Due Date Report(s) Due Oct 15, 2013 FY 12-13 Audited Financial Statements Oct 31, 2013 Q1 13 Q1 13-14 Financial Reports Jan 31, 2014 Q2 13-14 Investment Reports / Derivatives Reports Feb 14, 2014 Q2 13-14 Financial Reports Apr 25, 2014 FY 14-15 Annual Financial Plans & Strategy Statements Apr
Subcutaneous Emphysema Induced by Cryotherapy: A Complication due to Previous Punctures.
MartĒnez-Coronado, Jared; Torres-┴lvarez, Bertha; Castanedo-Cßzares, Juan Pablo
Cryosurgery is a common therapeutic modality used in dermatology; therefore we must be aware of its possible adverse effects. We report a case of a patient with subcutaneous emphysema which occurred following the application of cryotherapy after multiple punctures of local anesthetic and intralesional steroids in a chest keloid scar. Despite the fact that this condition was gradually resolved after expectant observation, we warn about this complication when sprayed cryotherapy is preceded by multiple punctures on cutaneous lesions above bony surfaces. In similar settings, cryotherapy must be first administered or a cotton-tip applicator should be used. PMID:26171258
Subcutaneous Emphysema Induced by Cryotherapy: A Complication due to Previous Punctures
MartĒnez-Coronado, Jared; Torres-┴lvarez, Bertha; Castanedo-Cßzares, Juan Pablo
Cryosurgery is a common therapeutic modality used in dermatology; therefore we must be aware of its possible adverse effects. We report a case of a patient with subcutaneous emphysema which occurred following the application of cryotherapy after multiple punctures of local anesthetic and intralesional steroids in a chest keloid scar. Despite the fact that this condition was gradually resolved after expectant observation, we warn about this complication when sprayed cryotherapy is preceded by multiple punctures on cutaneous lesions above bony surfaces. In similar settings, cryotherapy must be first administered or a cotton-tip applicator should be used. PMID:26171258
Pulmonary thromboembolism due to paliperidone: report of 2 cases.
?eng³l, Melike Ceyhan Balc?; Kaya, Kemal; Yilmaz, Atakan; ?eng³l, Cem; Serinken, Mustafa
Venous thromboembolism (VTE) is serious medical condition, which might be caused by psychotropic medications. Previously, antipsychotic-induced VTE due to olanzapine, risperidone, clozapine, and amisulpiride was reported. In this report, we present 2 cases of paliperidone-induced VTE. PMID:24462396
Case Report: Cellulitis Due to Salmonella infantis.
Carr, Leslie
1 Case Report: Cellulitis Due to Salmonella infantis. Authors Satish R Patil, Associate Professor. Cellulitis Due to Salmonella infantis. Online J Health Allied Scs. 2012;11(4):12. Available at URL Salmonella are highly adapted for the growth in both humans and animals and cause a wide spectrum of disease
Prolonged asthma after smoke inhalation: A report of three cases and a review of previous reports
Moisan, T.C. (Department of Preventive Medicine, Loyola University-Stritch School of Medicine, Maywood, IL (USA))
The development of prolonged obstructive airways disease after smoke inhalation is of concern to fire victims and fire fighters. Three cases of asthma that developed following the inhalation of pyrolysis products are presented along with a review of previous reports of airway injury from smoke inhalation. Polyvinyl chloride pyrolysis products seem to pose a high risk, but other toxic inhalants are also implicated. There is substantial evidence that prolonged airway hyper-responsiveness and asthma may follow numerous inflammatory insults including smoke inhalation. Studies to identify specific individual risk factors and asthmagenic pyrolysis products are needed. Early, postexposure anti-inflammatory treatment may modify the outcome. 42 refs.
Clinical study reports of randomised controlled trials: an exploratory review of previously confidential industry reports
Doshi, Peter; Jefferson, Tom
Objective To explore the structure and content of a non-random sample of clinical study reports (CSRs) to guide clinicians and systematic reviewers. Search strategy We searched public sources and lodged Freedom of Information requests for previously confidential CSRs primarily written by the industry for regulators. Selection criteria CSRs reporting sufficient information for extraction (æadequateÆ). Primary outcome measures Presence and length of essential elements of trial design and reporting and compression factor (ratio of page length for CSRs compared to its published counterpart in a scientific journal). Data extraction Data were extracted on standard forms and crosschecked for accuracy. Results We assembled a population of 78 CSRs (covering 90 randomised controlled trials; 144?610 pages total) dated 1991¢2011 of 14 pharmaceuticals. Report synopses had a median length of 5 pages, efficacy evaluation 13.5 pages, safety evaluation 17 pages, attached tables 337 pages, trial protocol 62 pages, statistical analysis plan 15 pages and individual efficacy and safety listings had a median length of 447 and 109.5 pages, respectively. While 16 (21%) of CSRs contained completed case report forms, these were accessible to us in only one case (765 pages representing 16 individuals). Compression factors ranged between 1 and 8805. Conclusions Clinical study reports represent a hitherto mostly hidden and untapped source of detailed and exhaustive data on each trial. They should be consulted by independent parties interested in a detailed record of a clinical trial, and should form the basic unit for evidence synthesis as their use is likely to minimise the problem of reporting bias. We cannot say whether our sample is representative and whether our conclusions are generalisable to an undefined and undefinable population of CSRs. PMID:23447465
Residual silicone detection using mri following previous breast implant removal: Case reports
Christina Y. Ahn; William W. Shaw; Krishna Narayanan; David P Gorczyca; Nanette D. DeBruhl; Lawrence W. Bassett
The current controversy surrounding the safety of silicone gel breast implants has resulted in an increasing number being removed. Although previous reports have suggested that remnants of the implant capsule are reabsorbed after explantation surgery, the persistence of the capsule in fact may be associated with implant fragments and silicone gel leakage. In this study we have used magnetic resonance
Cluster Report or Survey Description Date due to IEA Responsible
Fernandez, Eduardo
Cluster Report or Survey Description Date due to IEA Responsible person(s) Comments Reports Academic Information Reporting) #12;Cluster Report or Survey Description Date due to IEA Responsible person on Faculty 2010-11 Retention Survey Record of faculty for 2010-11 (# employed, hired, retirement, denied
Compartment syndrome due to massive leg hematoma after primary total hip arthroplasty: a previously unreported complication of fondaparinux.
Hannon, Michael G; Lamont, Justin G
Fondaparinux is an accepted form of deep venous thrombosis prophylaxis after hip arthroplasty. Cited advantages of its use include once-daily administration, standard dosage, and superiority as compared with enoxaparin. However, there have been several case reports of serious associated bleeding complications. We describe the case of a 77-year-old woman who developed a massive leg hematoma in the operative extremity nearly 3 weeks after a primary total hip arthroplasty while on fondaparinux. The patient developed a compartment syndrome requiring decompression of the hematoma, fasciotomy, and subsequent additional plastic surgery for split thickness skin grafting. PMID:22177799
Road accident due to a pancreatic insulinoma: a case report.
Parisi, Amilcare; Desiderio, Jacopo; Cirocchi, Roberto; Grassi, Veronica; Trastulli, Stefano; Barberini, Francesco; Corsi, Alessia; Cacurri, Alban; Renzi, Claudio; Anastasio, Fabio; Battista, Francesca; Pucci, Giacomo; Noya, Giuseppe; Schillaci, Giuseppe
Insulinoma is a rare pancreatic endocrine tumor, typically sporadic and solitary. Although the Whipple triad, consisting of hypoglycemia, neuroglycopenic symptoms, and symptoms relief with glucose administration, is often present, the diagnosis may be challenging when symptoms are less typical. We report a case of road accident due to an episode of loss of consciousness in a patient with pancreatic insulinoma. In the previous months, the patient had occasionally reported nonspecific symptoms. During hospitalization, endocrine examinations were compatible with an insulin-producing tumor. Abdominal computerized tomography and magnetic resonance imaging allowed us to identify and localize the tumor. The patient underwent a robotic distal pancreatectomy with partial omentectomy and splenectomy. Insulin-producing tumors may go undetected for a long period due to nonspecific clinical symptoms, and may cause episodes of loss of consciousness with potentially lethal consequences. Robot-assisted procedures can be performed with the same techniques of the traditional surgery, reducing surgical trauma, intraoperative blood loss, and hospital stays. PMID:25816027
Novel Endogenous Retrovirus in Rabbits Previously Reported as Human Retrovirus 5
Griffiths, David J.; Voisset, Cķcile; Venables, Patrick J. W.; Weiss, Robin A.
Human retrovirus 5 (HRV-5) represented a fragment of a novel retrovirus sequence identified in human RNA and DNA preparations. In this study, the genome of HRV-5 was cloned and sequenced and integration sites were analyzed. Using PCR and Southern hybridization, we showed that HRV-5 is not integrated into human DNA. A survey of other species revealed that HRV-5 is present in the genomic DNA of the European rabbit (Oryctolagus cuniculus) and belongs to an endogenous retrovirus family found in rabbits. The presence of rabbit sequences flanking HRV-5 proviruses in human DNA extracts suggested that rabbit DNA was present in our human extracts, and this was confirmed by PCR analysis that revealed the presence of rabbit mitochondrial DNA sequences in four of five human DNA preparations tested. The origin of the rabbit DNA and HRV-5 in human DNA preparations remains unclear, but laboratory contamination cannot explain the preferential detection of HRV-5 in inflammatory diseases and lymphomas reported previously. This is the first description of a retrovirus genome in rabbits, and sequence analysis shows that it is related to but distinct from A-type retroelements of mice and other rodents. The species distribution of HRV-5 is restricted to rabbits; other species, including other members of the order Lagomorpha, do not contain this sequence. Analysis of HRV-5 expression by Northern hybridization and reverse transcriptase PCR indicates that the virus is transcribed at a low level in many rabbit tissues. In light of these findings we propose that the sequence previously designated HRV-5 should now be denoted RERV-H (for rabbit endogenous retrovirus H). PMID:12072509
Adenylosuccinate lyase (ADSL) and infantile autism: Absence of previously reported point mutation
Fon, E.A.; Sarrazin, J.; Rouleau, G.A. [Montreal General Hospital (Canada)] [and others
Autism is a heterogeneous neuropsychiatric syndrome of unknown etiology. There is evidence that a deficiency in the enzyme adenylosuccinate lyase (ADSL), essential for de novo purine biosynthesis, could be involved in the pathogenesis of certain cases. A point mutation in the ADSL gene, resulting in a predicted serine-to-proline substitution and conferring structural instability to the mutant enzyme, has been reported previously in 3 affected siblings. In order to determine the prevalence of the mutation, we PCR-amplified the exon spanning the site of this mutation from the genomic DNA of patients fulfilling DSM-III-R criteria for autistic disorder. None of the 119 patients tested were found to have this mutation. Furthermore, on preliminary screening using single-strand conformation polymorphism (SSCP), no novel mutations were detected in the coding sequence of four ADSL exons, spanning approximately 50% of the cDNA. In light of these findings, it appears that mutations in the ADSL gene represent a distinctly uncommon cause of autism. 12 refs., 2 figs.
A case report about the reconstruction procedures of the previously failed cylinderical implants site using distraction osteogenesis
We report the eventually successful treatment of a huge bone defect and peri-implantitis following reconstruction of a previously failed intra-mobile cylinder implant system (IMZ) implant site using distraction osteogenesis (DO). In the anterior mandible, two IMZ implants failed and surgical debridement was performed in accordance to the patient's needs. Thereafter, mobility and suppuration were decreased and the patient visited the dental clinic on a regular basis for oral health maintenance. However, the inflammation did not resolve, and the bone destruction around the implants progressed for 4 years. Finally, the implants failed and a severe bone defect remained after implant removal. To reconstruct the bone defects, we attempted bone graft procedures. Titanium mesh was unsuccessfully used to obtain bone volume regeneration. However, DO subsequently was used to obtain sufficient bone volume for implant placement. The new implants were then installed, followed by prosthetic procedures. In conclusion, progression of peri-implantitis could not be arrested despite surgical intervention and repeated maintenance care for 3 years. Reconstruction of the peri-implantitis site was complicated due to its horizontal and vertical bone defects. Lesions caused by implant failure require an aggressive regenerative strategy, such as DO. DO was successful in reconstruction of a peri-implantitis site that was complicated due to horizontal and vertical bone defects. PMID:25922820
Therapeutic Foster Care--Update and Brief Summary of Previous Report
Walter, Uta M.; Petr, Chris
Therapeutic Foster Care Update 1 Best Practices in ChildrenÆs Mental Health A Series of Reports Summarizing the Empirical Research and other Pertinent Literature on Selected Topics Report # 15 Therapeutic Foster Care Brief Update... Best Practices in ChildrenÆs Mental Health Report # 1 ¢ October 2001, ōInpatient Treatment for Children and Adolescentsö Report # 2 ¢ November 2001, ōInpatient Treatment for Adolescent Substance Abusersö Report # 3 ¢ February 2002, ōGroup...
Appendectomy due to lead poisoning: a case-report
S Mohammadi; AH Mehrparvar; M Aghilinejad
BACKGROUND: Lead poisoning is a common occupational health hazard in developing countries and many misdiagnoses and malpractices may occur due to unawareness of lead poisoning symptoms. CASE PRESENTATION: We report a case of occupational lead poisoning in an adult battery worker with abdominal colic who initially underwent appendectomy with removal of normal appendix. Later on he was diagnosed with lead
Inducing Score Reliability from Previous Reports: An Examination of Life Satisfaction Studies
ERIC Educational Resources Information Center
Vassar, Matt; Ridge, Jason W.; Hill, Aaron D.
The sample specific nature of reliability is often overlooked in substantive research, with investigators frequently referencing reliability estimates from previous studies as the basis for presuming the score integrity for their data. The purpose of the current study was to examine this practice, known as reliability induction, across studiesģ
Large Vaginal and Bladder Calculi in a Woman With Previous Operation of Bladder Exstrophy: A Case Report
Tavakkoli, Mahmoud; Ghoreifi, Alireza
This is to report the case of a huge vaginal stone, and bladder calculi in a 26-year-old woman with previous operation of bladder exstrophy. It seems that the vaginal stone was secondary to the remaining wire used in her previous reconstructive surgery for pelvic closure 20 years ago and now surgery is performed to remove the vaginal and bladder stones. PMID:24719809
Osteomalacia in Chronic Renal Failure: a Syndrome Previously Reported Only with Maintenance Dialysis
Arnold J. Felsenfeld; Robert A. Gutman; Francisco Llach; John M. Harrelson
Osteomalacia without marked elevations of parathyroid hormone (PTH) has been described in maintenance dialysis patients. The proposed etiology has centered upon the transfer of an environmental agent (aluminum) from the dialysis water system. The present report describes an azotemic patient, who, prior to the initiation of dialytic therapy, presented with severe osteomalacia and low PTH concentrations for the severity of
Dissociative disorder due to Graves' hyperthyroidism: a case report.
Mizutani, Kaoru; Nishimura, Katsuji; Ichihara, Atsuhiro; Ishigooka, Jun
We report the case of a 20-year-old Japanese woman with no psychiatric history with apparent dissociative symptoms. These consisted of amnesia for episodes of shoplifting behaviors and a suicide attempt, developing together with an exacerbation of Graves' hyperthyroidism. Patients with Graves' disease frequently manifest various psychiatric disorders; however, very few reports have described dissociative disorder due to this disease. Along with other possible causes, for example, encephalopathy associated with autoimmune thyroid disease, clinicians should be aware of this possibility. PMID:24713328
Investigation of previously reported mucosal swellings after injection with Citanest Forte.
Giddon, Donald B.; Lebeaux, Michael
The purpose of this study was to determine the reason for an apparent increase in the number of mucosal swellings after maxillary infiltration with Citanest Forte (prilocaine HCl 4% solution with epinephrine 1:200,000), 2 years after its introduction in 1971 by Astra Pharmaceutical Co (now AstraZeneca) in the United States. Approximately 70% of these reported reactions were from California, where less than 11% of all cartridges were sold. Comparison with New York State, with 27% of total sales but less than 1% of the reactions, suggested that possible differences in practice characteristics were responsible for the swellings. On the basis of the Bureau of Economic Research and Statistics Survey of Dental Practice, dentists in the Far West (eg, California) were found to schedule appointments with a median length of approximately twice that of their Mid-East colleagues, the implication being that more anesthetic solution was injected per office visit. Follow-up telephone interviews of dentists reporting such reactions at that time verified that they administered more than the recommended 1.8-mL dose. The most important epidemiologic information was that prilocaine HCl 4% solution with epinephrine 1:200,000 had been on sale in Canada 4 years before it was introduced in the US market, with little or no evidence of drug-related effects. Comparison of the US and Canadian prilocaine HCl with epinephrine 1:200,000 specifications revealed that NaCl was added to an already hypertonic prilocaine solution in the US but not in Canada. Comparison of the responses to intradermal injection of US and Canadian prilocaine solutions into the backs of rabbits with follow-up studies of dose-related NaCl injections demonstrated that the added NaCl was responsible for the onset and duration of irritation from the initially marketed US Citanest solutions. PMID:12779112
Endocarditis due to Neisseria sicca: report of one case.
Chao, H C; Chiu, C H; Huang, Y C; Lin, T Y; Su, W J
Many species of the Neisseria, which are respiratory commensals in humans, have been regarded as being nonpathogenic or as causing disease in only immunocompromised hosts. We report a case in which Neisseria sicca was the cause of infective endocarditis in a child with a ventricular septal defect and review the literature on endocarditis due to N. sicca infection. Most of these patients had an underlying heart disease. Dental caries and poor oral hygiene may be two factors that predispose patients to the infection. N. sicca endocarditis usually results in a subacute onset of symptoms and, if not diagnosed early and treated, is associated with a high rate of embolic complications. PMID:9230543
Chronic mycobacterial meningitis due to Mycobacterium chelonae: a case report.
Salmanzadeh, Shokrallah; Honarvar, Negin; Goodarzi, Hamed; Khosravi, Azar Dokht; Nashibi, Roohangiz; Serajian, Amir Arsalan; Hashemzadeh, Mohammad
We report a case of chronic meningitis due to Mycobacterium chelonae. This organism is a rapidly growing Mycobacterium (RGM) and can be found worldwide in environmental sources such as soil, dust, and water. M. chelonae is an uncommon cause of meningitis; the majority of infections caused by this organism are localized cutaneous or soft tissue infections, and rarely lung infections. The organism is indistinguishable phenotypically, so we applied PCR based on the rpoB gene sequence followed by restriction fragment length polymorphism (RFLP) for molecular identification. The subsequent sequencing of RFLP products revealed 99.7% similarity with M. chelonae. PMID:25195074
Amendment to ATel 1859: CXOM31 J004245.9+411036 is Previously Reported XMMU J004245.9+411036
NASA Astrophysics Data System (ADS)
Galache, J. L.; Garcia, M. R.; Torres, M. A. P.; Murray, S. S.; Steeghs, D.; Williams, B. F.
The object CXOM31 J004245.9+411036, reported as a new X-ray source in ATel #1859 from M31 Chandra observations, is the previously reported XMMU J004245.9+411036 (Pietsch et al. 2008, ATel #1647). We thank W. Pietsch and M. Henze for kindly bringing this clerical error to our attention. This transient source has been observed by various space telescopes since its discovery. We present a table with known observations and the X-ray luminosity in the 0.5-5 keV range.
Reoperative sentinel lymph node biopsy for ipsilateral breast tumor recurrence after previous axillary lymph node dissection: Report of a case
Masaya Hattori; Seiichiro Nishimura; Keiichiro Tada; Masamichi Koyama; Futoshi Akiyama; Yoshinori Ito; Takuji Iwase
Sentinel lymph node biopsy has become a standard component of the evaluation of early-stage breast cancer, with a gradually\\u000a increasing number of indications in this patient population. This report presents the case of a patient who underwent reoperative\\u000a sentinel lymph node biopsy as part of an evaluation of ipsilateral breast tumor recurrence; she had previously undergone axillary\\u000a lymph node dissection.
The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy.
Hosseini, S Mohsen; Boright, Andrew P; Sun, Lei; Canty, Angelo J; Bull, Shelley B; Klein, Barbara E K; Klein, Ronald; Paterson, Andrew D
We investigated the association of signals from previous GWAS and candidate gene meta-analyses for diabetic retinopathy (DR) or nephropathy (DN), as well as an EPO variant in meta-analyses of severe (SDR) and mild diabetic retinopathy (MDR). Meta-analyses of SDR (?severe non-proliferative diabetic retinopathy (NPDR) or history of panretinal photocoagulation) and MDR (?mild NPDR), defined based on seven-field stereoscopic fundus photographs, were performed in two well-characterized type 1 diabetes (T1D) cohorts: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC, nĀ=Ā1,304) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR, nĀ=Ā603). Among 34 previous signals for DR, after controlling for multiple testing, no association was replicated in our meta-analyses. rs1571942 and rs12219125 at PLXDC2 locus showed nominally significant (<0.05) association with SDR in the same direction as previous report, as did rs1801282 in PPARG gene with MDR. Among 55 loci previously associated with DN, three showed suggestive associations with SDR in our study without maintaining significance after correction for multiple testing. Of particular interest, rs1617640 (EPO) was not significantly associated with DR status, combined SDR-DN phenotype, time to SDR or time to DN (all PĀ>Ā0.05). Lack of replication of previous DR hits and EPO despite reasonable statistical power implies that many of these may be false positives. Consistent with pleiotropy, we provide suggestive collective evidence for association between DR and variants previously associated with DN without reaching statistical significance at any single locus. PMID:25487307
Specific SSRIs and birth defects: bayesian analysis to interpret new data in the context of previous reports
Devine, Owen; Friedman, Jan M; Louik, Carol; Honein, Margaret A
Objective To follow up on previously reported associations between periconceptional use of selective serotonin reuptake inhibitors (SSRIs) and specific birth defects using an expanded dataset from the National Birth Defects Prevention Study. Design Bayesian analysis combining results from independent published analyses with data from a multicenter population based case-control study of birth defects. Setting 10 centers in the United States. Participants 17?952 mothers of infants with birth defects and 9857 mothers of infants without birth defects, identified through birth certificates or birth hospitals, with estimated dates of delivery between 1997 and 2009. Exposures Citalopram, escitalopram, fluoxetine, paroxetine, or sertraline use in the month before through the third month of pregnancy. Posterior odds ratio estimates were adjusted to account for maternal race/ethnicity, education, smoking, and prepregnancy obesity. Main outcome measure 14 birth defects categories that had associations with SSRIs reported in the literature. Results Sertraline was the most commonly reported SSRI, but none of the five previously reported birth defects associations with sertraline was confirmed. For nine previously reported associations between maternal SSRI use and birth defect in infants, findings were consistent with no association. High posterior odds ratios excluding the null value were observed for five birth defects with paroxetine (anencephaly 3.2, 95% credible interval 1.6 to 6.2; atrial septal defects 1.8, 1.1 to 3.0; right ventricular outflow tract obstruction defects 2.4, 1.4 to 3.9; gastroschisis 2.5, 1.2 to 4.8; and omphalocele 3.5, 1.3 to 8.0) and for two defects with fluoxetine (right ventricular outflow tract obstruction defects 2.0, 1.4 to 3.1 and craniosynostosis 1.9, 1.1 to 3.0). Conclusions These data provide reassuring evidence for some SSRIs but suggest that some birth defects occur 2-3.5 times more frequently among the infants of women treated with paroxetine or fluoxetine early in pregnancy. PMID:26156519
Myocerebrohepatopathy spectrum disorder due to POLG mutations: A clinicopathological report.
Montassir, Hesham; Maegaki, Yoshihiro; Murayama, Kei; Yamazaki, Taro; Kohda, Masakazu; Ohtake, Akira; Iwasa, Hiroyasu; Yatsuka, Yukiko; Okazaki, Yasushi; Sugiura, Chitose; Nagata, Ikuo; Toyoshima, Mitsuo; Saito, Yoshiaki; Itoh, Masayuki; Nishino, Ichizo; Ohno, Kousaku
We report on the clinical, neuropathological, and genetic findings of a Japanese case with myocerebrohepatopathy spectrum (MCHS) disorder due to polymerase gamma (POLG) mutations. A girl manifested poor sucking and failure to thrive since 4months of age and had frequent vomiting and developmental regression at 5months of age. She showed significant hypotonia and hepatomegaly. Laboratory tests showed hepatocellular dysfunction and elevated protein and lactate levels in the cerebrospinal fluid. Her liver function and neurologic condition exacerbated, and she died at 8months of age. At autopsy, fatty degeneration and fibrosis were observed in the liver. Neuropathological examination revealed white matter-predominant spongy changes with Alzheimer type II glia and loss of myelin. Enzyme activities of the respiratory chain complex I, III, and IV relative to citrate synthase in the muscle were normal in the biopsied muscle tissue, but they were reduced in the liver to 0%, 10%, and 14% of normal values, respectively. In the liver, the copy number of mitochondrial DNA compared to nuclear DNA was reduced to 3.3% of normal values as evaluated by quantitative polymerase chain reaction. Genetic analysis revealed compound heterozygous mutations for POLG (I1185T/A957V). This case represents the differential involvement of multiple organs and phenotype-specific distribution of brain lesions in mitochondrial DNA depletion disorders. PMID:25466440
A different sequence of events than previously reported leads to arsenic-induced damage in Ceratophyllum demersum L.
Mishra, Seema; Stõrk, Hans-Joachim; K³pper, Hendrik
Arsenic (As) is a common pollutant, and still many questions remain concerning As toxicity mechanisms under environmentally relevant conditions in plants. Here we investigated thresholds and interactions of various proposed As toxicity mechanisms. Experiments were done under environmentally pertinent conditions in the rootless aquatic macrophyte Ceratophyllum demersum L., a model for plant shoots. Arsenic (provided as As(v)) inhibited plant metabolism at much lower concentrations and with a different sequence of events than previously reported. The first observed effect of toxicity was a decrease in pigment concentration, it started even at 0.5 ?M As. In contrast to toxic metals, no inhibition of the photosystem II reaction centre (PSIIRC; measured as Fv/Fm) was found at sublethal As concentrations. Instead, the decrease in light harvesting pigments caused a less efficient exciton transfer towards the PSIIRC. At higher As concentrations this led to increased non-photochemical quenching (NPQ) by light harvesting complex II (LHCII). Afterwards, photosynthetic electron transport decreased, but the increase in starch content indicated stronger inhibition of starch consumption than production. At lethal As concentration, photosynthesis was completely inhibited, its malfunction caused oxidative stress and not the other way round as reported previously. Photosynthesis was inhibited before any sign of oxidative stress was observed. Elevated phosphate drastically shifted thresholds of lethal As effects, not only by the known uptake competition but also by modifying uptake regulation and intracellular processes. PMID:24382492
50 CFR 86.81 - When are the reports due?
Code of Federal Regulations, 2010 CFR
...SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the States ¦ 86.81...d) The State must report certified percentage of completion data and other significant developments in accordance with the...
50 CFR 86.81 - When are the reports due?
Code of Federal Regulations, 2013 CFR
...SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the States ¦ 86.81...d) The State must report certified percentage of completion data and other significant developments in accordance with the...
50 CFR 86.81 - When are the reports due?
Code of Federal Regulations, 2014 CFR
...SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the States ¦ 86.81...d) The State must report certified percentage of completion data and other significant developments in accordance with the...
50 CFR 86.81 - When are the reports due?
Code of Federal Regulations, 2011 CFR
...SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the States ¦ 86.81...d) The State must report certified percentage of completion data and other significant developments in accordance with the...
50 CFR 86.81 - When are the reports due?
Code of Federal Regulations, 2012 CFR
...SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the States ¦ 86.81...d) The State must report certified percentage of completion data and other significant developments in accordance with the...
[Double mutant alleles in the EXT1 gene not previously reported in a teenager with hereditary multiple exostoses].
Cammarata-Scalisi, Francisco; Cozar, M¾nica; Grinberg, Daniel; Balcells, Susana; Asteggiano, Carla G; MartĒnez-Domenech, Gustavo; Bracho, Ana; Sßnchez, Yanira; Stock, Frances; Delgado-Luengo, Wilmer; Zara-Chirinos, Carmen; ChacĒn, Josķ Antonio
Hereditary forms of multiple exostoses, now called EXT1/EXT2-CDG within Congenital Disorders of Glycosylation, are the most common benign bone tumors in humans and clinical description consists of the formation of several cartilage-capped bone tumors, usually benign and localized in the juxta-epiphyseal region of long bones, although wide body dissemination in severe cases is not uncommon. Onset of the disease is variable ranging from 2-3 years up to 13-15 years with an estimated incidence ranging from 1/18,000 to 1/50,000 cases in European countries. We present a double mutant alleles in the EXT1 gene not previously reported in a teenager and her family with hereditary multiple exostoses. PMID:25727835
Marked increase in incidence for bloodstream infections due to Escherichia coli, a side effect of previous antibiotic therapy in the elderly
van der Mee-Marquet, Nathalie L.; Blanc, Dominique S.; Gbaguidi-Haore, Houssein; Dos Santos Borges, Sandra; Viboud, Quentin; Bertrand, Xavier; Quentin, Roland
We conducted a survey including 3334 bloodstream infections (BSIs) due to E. coli diagnosed in 2005¢2014 at a stable cohort of hospitals. Marked increases in incidence were observed for community-acquired (CA) BSIs in patients aged >75 years, CA-BSIs of digestive origin in patients aged 60¢74 years, healthcare-associated BSIs, and BSIs associated with ESBL (extended-spectrum B-lactamase)-producing E. coli (ESBLEc). Using MLST, we studied the genetic diversity of 412 BSI isolates recovered during the 2014 survey: 7 major sequence type complexes (STCs) were revealed in phylogenetic group B2, 3 in group A/B1 and 2 in group D. Among the 31 ESBLEc isolates, 1/3 belonged to STC 131. We searched for possible associations between clonal groups, clinical determinants and characteristics of BSIs: isolates from groups B2 (except STC 131) and D were susceptible to antibiotics and associated with BSIs of urinary origin in patients <60 years. STC 131 and group A/B1 isolates were multi-drug resistant and associated with CA-BSIs of digestive origin in patients aged 60¢74 with a recent history of antibiotic treatment. STC 131 isolates were associated with HCA-BSIs in patients with recent/present hospitalization in a long-stay unit. We provide a unique population-based picture of the epidemiology of E. coli BSI. The aging nature of the population led to an increase in the number of cases caused by the B2 and D isolates generally implicated in BSIs. In addition, the association of a trend toward increasing rates of gut colonization with multi drug-resistant isolates revealed by the rise in the incidence of BSIs of digestive origin caused by STC 131 and A/B1 (STCs 10, 23, and 155) isolates, and a significant increase in the frequency of BSIs in elderly patients with recent antibiotic treatment suggested that antibiotic use may have contributed to the growing incidence of BSI. PMID:26175721
Clinical Characteristics, Patient-Reported Outcomes, and Previous Therapeutic Management of Patients with Uncontrolled Neuropathic Pain Referred to Pain Clinics
de Andrķs, Josķ; de la Calle, Josķ-Luis; Pķrez, MarĒa; L¾pez, Vanessa
Background. The aim of this report was to evaluate the clinical profile and previous management of patients with uncontrolled neuropathic pain who were referred to pain clinics. Methods. We included adult patients with uncontrolled pain who had a score of ?4 in the DN4 questionnaire. In addition to sociodemographic and clinical data, we evaluated pain levels using a visual analog scale as well as anxiety, depression, sleep, disability, and treatment satisfaction employing validated tools. Results. A total of 755 patients were included in the study. The patients were predominantly referred to pain clinics by traumatologists (34.3%) and primary care physicians (16.7%). The most common diagnoses were radiculopathy (43%) and pain of oncological origin (14.3%). The major cause for uncontrolled pain was suboptimal treatment (88%). Fifty-three percent of the patients were depressed, 43% had clinical anxiety, 50% rated their overall health as bad or very bad, and 45% noted that their disease was severely or extremely interfering with their daily activities. Conclusions. Our results showed that uncontrolled neuropathic pain is a common phenomenon among the specialties that address these clinical entities and, regardless of its etiology, uncontrolled pain is associated with a dramatic impact on patient well-being. PMID:24891950
45 CFR 265.4 - When are quarterly reports due?
Code of Federal Regulations, 2010 CFR
...or be subject to a penalty. (b) Each State that claims MOE expenditures for a separate State program(s) must file the SSP-MOE Data Report within 45 days following the end of the quarter or be subject to a penalty. (c) A State that...
Calcific myofibrosis due to pentazocine abuse: a case report
Vinay Goyal; Jatinder M Chawla; Yatan PS Balhara; Garima Shukla; Sumit Singh; Madhuri Behari
INTRODUCTION: Pentazocine, a synthetic narcotic analgesic, is commonly used for the relief of moderate to severe pain secondary to various conditions. It is usually well tolerated; however, adverse effects are not uncommon, especially when higher doses are used and when it is used in a dependent fashion. There have been reports of various complications associated with its use, including skin
A novel observation of pubic osteomyelitis due to Streptococcus viridans after dental extraction: a case report
Naqvi, Naseem; Naqvi, Rizwana; Wong, Christopher; Pearce, Sushmita
Introduction Pubic osteomyelitis should be suspected in athletic individuals with sudden groin pain, painful restriction of hip movements and fever. It is an infrequent and confusing disorder, which is often heralded by atypical gait disturbance and diffuse pain in the pelvic girdle. The most common pathogen is Staphylococcus aureus but, on occasions, efforts to identify infectious agents sometimes prove negative. Pubic osteomyelitis due to Streptococcus viridans has not been reported previously in the literature. Case presentation We describe the case of a fit 24-year-old athlete, who had a wisdom tooth extracted 2 weeks prior to the presentation, which could have served as a port of entry and predisposed the patient to transient bacteraemia. Conclusion S. viridans is well known for causing infective endocarditis of native damaged heart valves, but to the best of the authors' knowledge it has not been reported previously as a cause of pubic osteomyelitis. We believe that this case should alert physicians to the association between dental procedures and osteomyelitis of the pubis secondary to S. viridans. PMID:18671843
Scuba diver deaths due to air embolism: two case reports.
T³rkmen, Nursel; Akan, Okan; Cetin, Selńuk; Eren, B³lent; G³rses, Murat Serdar; G³ndo?mu?, Umit Naci
Barotraumas and decompression sickness are the two most well-known complications of diving. First presented case was 32 year-old male with recreational diver, who was found floating prone position on the bottom of sea in a depth of 33 m. He had been carried to the surface in a controlled ascent. Second case was a 39 year-old male experienced dive instructor in a diving school, after following an uneventful duration of dive was found unconscious with a floating supine position in a depth of 30 m and there were no signs of life when they were transported to the hospital. Extensive subcutaneous emphysema of the extremities was detected by palpation of the skin. In the autopsy diffuse gas bubbles like beads were seen in the coronary arteries and in ventricles, basilar artery and all of the cerebral arteries. The cause of death was attributed due to gas embolism and drowning. PMID:23641724
Meningitis and bacteremia due to Bacillus cereus. A case report and a review of Bacillus infections.
Siegman-Igra, Y; Lavochkin, J; Schwartz, D; Konforti, N
A patient with meningitis and bacteremia due to Bacillus cereus is described. The patient had transsphenoidal hypophysectomy for chromophobe adenoma, complicated by rhinorrhea, which was corrected by subarachnoid drainage. Three weeks after removal of the drain, the patient presented with meningitis and died the following day. The causative organism was identified as B. cereus. The literature on Bacillus infections is reviewed with special attention to severe infections. A modified classification is proposed, dividing infections into superficial, closed-space and systemic ones. Sixty-one previously reported cases of systemic Bacillus infections are reviewed according to type of infection (endocarditis, meningitis or pulmonary infection), and the underlying conditions, ways of acquiring the infection, clinical picture and mortality are discussed. PMID:6408023
Mandibular osteomyelitis due to Pseudomonas aeruginosa. Case report.
Pappalardo, S; Tanteri, L; Brutto, D; Marescalco, M; Carlino, V; Consolo, G; Mauro, M; Cappello, V
Osteomyelitis is a relatively frequent bacterial infection of the jaw bones. This report describes a case of mandibular osteomyelitis in a surgical site after enucleation of a follicular cyst and extraction of the associated tooth. This case is unusual because maxillary osteomyelitis generally results from polymicrobial infection. In our patient, however, laboratory analysis identified Pseudomonas aeruginosa as the etiologic agent, an opportunistic pathogen normally found on moist surfaces and vegetation. Notorious for its antibiotic multiresistance, P. aeruginosa is increasingly recognized as a serious problem in hospitalized patients. Isolation of the responsible microbe permitted specific antibiotic treatment with a 10-day course of ciprofloxacin (250 mg/12 h), which fully cleared the infection. PMID:18617880
[Anxiety disorder due to epilepsy: a case report].
ųzyurt, Gonca; ųztura, ?brahim; Alk?n, Tunń; ųzerdem, Ay?eg³l
Epileptic patients present with psychiatric disorders more frequently than the general population and patients with other chronic medical conditions. Psychiatric disorders can co-occur with epilepsy and can be caused by epilepsy. Personality changes, as well as psychosis, and mood or anxiety disorders can occur in association with epilepsy. Anxiety disorders due to epilepsy can manifest as generalized anxiety disorder, panic disorder, phobias, or obsessive-compulsive disorder. The risk of an anxiety disorder is higher in patients with focal epilepsy, especially those with temporal lobe epilepsy, but an anxiety disorder can also occur in patients with frontal lobe epilepsy or generalized tonic-clonic epilepsy. Herein we present a 41-year-old female patient with comorbid anxiety disorder and epilepsy that improved following initiation of antiepileptic medication. The patient's EEG showed abnormalities, particularly in the frontal lobe. Epileptic activation-associated anxiety disorder presented as phobia of swallowing and the patient exhibited features of generalized anxiety disorder. Following initiation of antiepileptic medication, the seizures stopped and the symptoms of anxiety disappeared in two weeks. The patient was receiving psychotherapy once every 2 weeks. The patient remained asymptomatic during 2-years of follow-up. This case highlights the importance of differential diagnosis of underlying epilepsy in patients with acute severe anxiety and the efficacy of proper medical treatment, which was given in the presented case for the underling pathology of anxiety. PMID:25742040
On some Panamerican Cretaceous crabs (Decapoda: Raninoida) 263 Decapod crustacean specimens recently collected from new and previously reported localities of USA, Mexico, and Colombia, as
Bermingham, Eldredge
specimens recently collected from new and previously reported localities of USA, Mexico, and Colombia Colombia, Oklahoma and Mexico. Specimens of Cenomanocarcinus vanstraeleni from the Turonian of Mexico and Colombia include features not described previously for this species, such as variation in the shape
Osmotic shock tolerance and membrane fluidity of cold-adapted Cryptococcus flavescens OH 182.9, previously reported as Cr. nodaensis, a biocontrol agent of Fusarium head blight
Technology Transfer Automated Retrieval System (TEKTRAN)
Cryptococcus nodaensis (previously reported as Cr. nodaensis), a biological control agent of Fusarium head blight, has been previously shown to have improved desiccation tolerance after cold adaptation. The goal of the current study was to determine the effect of cold adaptation on the physicochemi...
41 CFR 102-84.55 - When are the Annual Real Property Inventory reports due?
Code of Federal Regulations, 2010 CFR
...Annual Real Property Inventory reports due? ...Contracts and Property Management Federal Property Management Regulations System...Continued) FEDERAL MANAGEMENT REGULATION REAL...84-ANNUAL REAL PROPERTY INVENTORIES ¦...
41 CFR 102-84.55 - When are the Annual Real Property Inventory reports due?
Code of Federal Regulations, 2011 CFR
...Annual Real Property Inventory reports due? ...Contracts and Property Management Federal Property Management Regulations System...Continued) FEDERAL MANAGEMENT REGULATION REAL...84-ANNUAL REAL PROPERTY INVENTORIES ¦...
41 CFR 102-84.55 - When are the Annual Real Property Inventory reports due?
Code of Federal Regulations, 2012 CFR
...Annual Real Property Inventory reports due? ...Contracts and Property Management Federal Property Management Regulations System...Continued) FEDERAL MANAGEMENT REGULATION REAL...84-ANNUAL REAL PROPERTY INVENTORIES ¦...
Case report and review of septicemia due to Serratia ficaria.
Darbas, H; Jean-Pierre, H; Paillisson, J
Serratia ficaria was first described in 1979 as part of the fig tree ecosystem (P.A.D. Grimont, F. Grimont, and M. P. Starr, Curr. Microbiol. 2:277-282, 1979). Since then, it has been isolated from clinical specimens from a few human patients (C. Bollet, J. Freney, P. de Micco, F. Grimont, and P.A.D. Grimont, Mķd. Mal. Infect. 20:97-100, 1990; J.A. Brouillard, W. Hansen, and A. Compere, J. Clin. Microbiol. 19:902-904, 1984; H. Darbas, H. Jean-Pierre, G. Boyer, and M. Riviere, Mķd. Mal. Infect. 23:269-270, 1993; V.J. Gill, J.J. Farmer, III, P.A.D. Grimont, M.A. Asbury, and C.L. McIntosh, J. Clin. Microbiol. 14:234-236, 1981; F.D. Pien and J.J. Farmer III, South. Med. J. 76:1591-1592, 1983; C. Richard, J. de Coquet, and C. Suc, Mķd. Mal. Infect. 19:45-47, 1989), but the pathogenicity of S. ficaria was always questionable. We are reporting the case of an aged cancer patient who developed S. ficaria septicemia. The habitat of this organism and its potential role as a pathogen are discussed. PMID:7814560
Fetishism Due to Methamphetamine (Glass) Abuse: A Case Report
Mehdizadeh-Zareanari, Ali; Ghafarinezhad, Alireza; Soltani, Hoda
Background Fetishism is a type of paraphilia. The focus of sexual arousal in fetishism is oriented towards inanimate objects. Sexual arousal and craving are some of the reasons the youth resort to crystal (glass). Drug abuse may cause disorders in sexual function. Case Report The patient was a 41 years old man. He married in age 22 years and experienced frequent intercourses with his wife from which he gained pleasure and it was his preferable method. Her wife left ten years ago. The patient started crystal administration through insufflations since seven months ago. Simultaneous with crystal abuse, wearing womenÆs underwear was the only medium through which the patient reached sexual orgasm. Discussion A lot of psychological symptoms related to new substances (for example glass) are new to psychiatrists treating dependency in medical clinics. Fetishism may coexist with addiction as comorbidity. Another point to be mentioned is that, symptoms of fetishism increased and decreased with more and less glass administration, indicating that symptoms of paraphilia emerge as a result of glass use. In addition, prior to glass use, the patient maintained normal sexual tendencies, had experienced sexual intercourse and did not suffer from any type of paraphilia. PMID:24494161
Nonobstructive hydronephrosis due to social polydipsia: a case report
Introduction Excessive fluid intake can lead to water intoxication, electrolyte abnormalities, exacerbation of heart failure and anatomical changes in the urinary tract that may present diagnostic and therapeutic challenges for patients and physicians. Although the development of nonobstructive hydronephrosis is recognized in patients with central and nephrogenic diabetes insipidus, pregnancy or psychiatric polydipsia, it is rarely a diagnostic consideration in healthy individuals with excessive fluid ingestion. We now present what we believe to be the first report of nonobstructive hydronephrosis associated with social polydipsia. Case presentation A 53-year-old African-American woman with moderate back pain was found to have bilateral moderate hydronephrosis and hydroureter by abdominal computed tomography. She underwent ureteral stent placement followed by exploratory laparoscopy with lysis of adhesions and a right oophorectomy, without resolution of the nonobstructive hydronephrosis. A careful assessment revealed a social habit of consuming approximately 5.5L of fluid daily in an effort to remain hydrated in accordance with public health service announcements. It was recommended that the patient reduce her fluid intake. A repeat ultrasound after six weeks revealed complete resolution of the bilateral hydronephrosis and hydroureter. Conclusion Recognition of the nonobstructive nature of hydronephrosis caused by polydipsia in healthy individuals is important to prevent unnecessary interventions. PMID:23130747
24 CFR 1710.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2014 CFR
...filings-notice of revocation rights on property report cover page. 1710.558 Section 1710.558 Housing and...notice of revocation rights on property report cover page. (a)(1) The cover page on Property Reports for filings made with the...
24 CFR 1710.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2010 CFR
...filings-notice of revocation rights on property report cover page. 1710.558 Section 1710.558 Housing and...notice of revocation rights on property report cover page. (a)(1) The cover page on Property Reports for filings made with the...
24 CFR 1710.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2013 CFR
...filings-notice of revocation rights on property report cover page. 1710.558 Section 1710.558 Housing and...notice of revocation rights on property report cover page. (a)(1) The cover page on Property Reports for filings made with the...
24 CFR 1710.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2011 CFR
...filings-notice of revocation rights on property report cover page. 1710.558 Section 1710.558 Housing and...notice of revocation rights on property report cover page. (a)(1) The cover page on Property Reports for filings made with the...
24 CFR 1710.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2012 CFR
...filings-notice of revocation rights on property report cover page. 1710.558 Section 1710.558 Housing and...notice of revocation rights on property report cover page. (a)(1) The cover page on Property Reports for filings made with the...
Examining the Effect of Previously Missing Blood Lead Level (BPb) Surveillance Data on Results Reported in the
05/20/2010 Examining the Effect of Previously Missing Blood Lead Level (BPb) Surveillance Data concentrations in its drinking water. In February 2004, DC DOH requested that CDC assess the health effects that the missing BPb test results might have resulted in an underestimation of the effect elevated drinking water
30 CFR 1210.103 - When are my production reports due?
Code of Federal Regulations, 2012 CFR
...and Gas ¦ 1210.103 When are my production reports due? (a) The ONRR must receive your completed Forms MMS-4054 and MMS-4058 by the 15th day of the second month following the month for which you are reporting. (b) A report...
12 CFR 1010.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2012 CFR
...pursuant to ¦ 1010.552 shall be prepared in accordance with ¦ 1010.105 and shall include the paragraphs set forth in section XXX of the appendix to this part: Language to be Included on Property Report Cover Page. (2) If the purchaser is...
12 CFR 1010.558 - Previously accepted state filings-notice of revocation rights on property report cover page.
Code of Federal Regulations, 2013 CFR
...pursuant to ¦ 1010.552 shall be prepared in accordance with ¦ 1010.105 and shall include the paragraphs set forth in section XXX of the appendix to this part: Language to be Included on Property Report Cover Page. (2) If the purchaser is...
GradenigoÆs syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: a case report
Introduction GradenigoÆs syndrome is nowadays a rare condition characterized by a triad of otorrhea, facial pain with trigeminal nerve involvement and abducens nerve palsy. Most cases are caused by medial extension of acute otitis media into a pneumatized petrous apex and surgical drainage is usually the treatment of choice. We present a case highlighting the pathological mechanism of this disease, demonstrate rare radiological findings associated with this patient, and showcase successful medical treatment without surgical intervention. Case presentation A 63-year-old Thai man presented with complete Gradenigo triad as a complication of chronic otomastoiditis in spite of clinical history of previous radical mastoidectomy and a nonpneumatization of the petrous apex. Magnetic resonance imaging showed abnormal prominent enhancement at the roof of his right temporal bone, and the dura overlying the floor of right middle cranial fossa and right cavernous sinus. Magnetic resonance imaging also detected right petrous apicitis. With the use of intravenous antibiotics and topical antibiotic eardrops, recovery was observed within 5 days with complete resolution within 2 months. Conclusions Although there is little evidence to support the use of medical therapy in the treatment of GradenigoÆs syndrome resulting from chronic ear disease, we here demonstrate successful conservative treatment of GradenigoÆs syndrome following chronic otitis media in a patient who underwent previous radical mastoidectomy. PMID:24957520
Analysis of Over 10,000 Cases Finds No Association between Previously-Reported Candidate Polymorphisms and Ovarian Cancer Outcome
White, Kristin L.; Vierkant, Robert A.; Fogarty, Zachary C.; Charbonneau, Bridget; Block, Matthew S.; Pharoah, Paul D.P.; Chenevix-Trench, Georgia; Rossing, Mary Anne; Cramer, Daniel W.; Pearce, C. Leigh; Schildkraut, Joellen M.; Menon, Usha; Kjaer, Susanne Kruger; Levine, Douglas A.; Gronwald, Jacek; Culver, Hoda Anton; Whittemore, Alice S.; Karlan, Beth Y.; Lambrechts, Diether; Wentzensen, Nicolas; Kupryjanczyk, Jolanta; Chang-Claude, Jenny; Bandera, Elisa V.; Hogdall, Estrid; Heitz, Florian; Kaye, Stanley B.; Fasching, Peter A.; Campbell, Ian; Goodman, Marc T.; Pejovic, Tanja; Bean, Yukie; Lurie, Galina; Eccles, Diana; Hein, Alexander; Beckmann, Matthias W.; Ekici, Arif B.; Paul, James; Brown, Robert; Flanagan, James; Harter, Philipp; du Bois, Andreas; Schwaab, Ira; Hogdall, Claus K.; Lundvall, Lene; Olson, Sara H.; Orlow, Irene; Paddock, Lisa E.; Rudolph, Anja; Eilber, Ursula; Dansonka-Mieszkowska, Agnieszka; Rzepecka, Iwona K.; Ziolkowska-Seta, Izabela; Brinton, Louise; Yang, Hannah; Garcia-Closas, Montserrat; Despierre, Evelyn; Lambrechts, Sandrina; Vergote, Ignace; Walsh, Christine; Lester, Jenny; Sieh, Weiva; McGuire, Valerie; Rothstein, Joseph H.; Ziogas, Argyrios; Lubi?ski, Jan; Cybulski, Cezary; Menkiszak, Janusz; Jensen, Allan; Gayther, Simon A.; Ramus, Susan J.; Gentry-Maharaj, Aleksandra; Berchuck, Andrew; Wu, Anna H.; Pike, Malcolm C.; Van Den Berg, David; Terry, Kathryn L.; Vitonis, Allison F.; Doherty, Jennifer A.; Johnatty, Sharon; deFazio, Anna; Song, Honglin; Tyrer, Jonathan; Sellers, Thomas A.; Phelan, Catherine M.; Kalli, Kimberly R.; Cunningham, Julie M.; Fridley, Brooke L.; Goode, Ellen L.
Background Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNPs) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes. Methods Twenty-seven SNPs in VHL, HGF, IL18, PRKACB, ABCB1, CYP2C8, ERCC2, and ERCC1 previously associated with ovarian cancer outcome were genotyped in 10,084 invasive cases from 28 studies from the Ovarian Cancer Association Consortium with over 37,000 observed person-years and 4,478 deaths. Cox proportional hazards models were used to examine the association between candidate SNPs and ovarian cancer recurrence or survival with and without adjustment for key covariates. Results We observed no association between genotype and ovarian cancer recurrence or survival for any of the SNPs examined. Conclusions These results refute prior associations between these SNPs and ovarian cancer outcome and underscore the importance of maximally powered genetic association studies. Impact These variants should not be used in prognostic models. Alternate approaches to uncovering inherited prognostic factors, if they exist, are needed. PMID:23513043
A case report of huge perirenal liposarcoma associated with renal cell carcinoma and reviews of three previous cases
Liu, Zhe; Xu, Yuanhong; Long, Jin; Guo, Kejian; Du, Ruixia
Retroperitoneal liposarcoma (RPLS) is a rare malignant tumor yet with a high recurrence rate. It is mostly observed in limbs and during retroperitoneal clearance, and accounts for nearly 40% of all adult retroperitoneal soft tissue sarcomas [1]. Renal cell carcinoma (RCC) is a common cancer developed in urinary system and its occurrence rate accounts for 3% of whole body malignant tumors [2]. In this report, we present a case of large perirenal liposarcoma associated with RCC, which is to date the fourth identified case. We analyzed the clinical pathologic data of this patient and reviewed the other three cases. Compared to the other cases, this patient is diagnosed at the youngest age and the liposarcoma tumor is with the largest diameter. Moreover, we have been following up the patient after operation for the longest time. All of these made this report rare and important. PMID:25550981
Providing Internet access to Los Alamos National Laboratory technical reports: A case history in providing public access to previously restricted documents
Collins, K.A.
The Los Alamos National Laboratory (LANL) Research Library recently fulfilled a strategic goal of providing worldwide desktop access via the Internet to full-image files of the complete unclassified holdings of Los Alamos technical reports in its Report Collection. This effort began in late 1994 with the scanning of paper and microfiche format reports. Concurrently, the Research Library helped to initiate shifting the model for publishing new technical reports from paper to electronic; the files could then be directly mounted on the Research Library`s Web server. Providing desktop access to these reports was instrumental in expediting the development of internal policies that would better define what documents, previously restricted to the general public, could be publicly released. Undoubtedly, the most significant category of such reports were previously classified reports that had been declassified, but had not gone through a further review for public release. Collaboration with LANL`s Classification Group led to approval for public release of 97% of these reports. The LANL Research Library`s Web site now offers unique and unprecedented access to the world of a huge body of technical reports never available before anywhere in any form. This paper discusses the issues and steps involved in this achievement.
Outcome of unicompartmental knee arthroplasty in octogenarians with tricompartmental osteoarthritis: A longer followup of previously published report
Marya, Sanjiv KS; Thukral, Rajiv
Background: Unicompartmental knee arthroplasty (UKA) has specific indications, producing excellent results. It, however, has a limited lifespan and needs eventual conversion to total knee arthroplasty (TKA). It is, therefore, a temporizing procedure in select active young patients with advanced unicompartmental osteoarthritis (UCOA). Being a less morbid procedure it is suggested as an alternative in the very elderly patients with tricompartmental osteoarthritis (TCOA). We performed UKA in a series of 45 octogenarians with TCOA predominant medial compartment osteoarthritis (MCOA) and analyzed the results. Materials and Methods: Forty five octogenarian patients with TCOA predominant MCOA underwent UKA (19 bilateral) from January 2002 to January 2012. All had similar preoperative work-up, surgical approach, procedure, implants and postoperative protocol. Clinicoradiological assessment was done at 3-monthly intervals for the first year, then yearly till the last followup (average 72 months, range 8-128 months). Results were evaluated using the knee society scores (KSS), satisfaction index [using the visual analogue scale (VAS)] and orthogonal radiographs (for loosening, subsidence, lysis or implant wear). Resurgery for any cause was considered failure. Results: Four patients (six knees) died due to medical conditions, two patients (three knees) were lost to followup, and these were excluded from the final analysis. Barring two failures, all the remaining patients were pain-free and performing well at the final followup. Indications for resurgery were: medial femoral condyle fracture needing fixation subsequent conversion to TKA at 2 years (n=1) and progression of arthritis and pain leading to revision TKA at 6 years (n=1). Conclusion: UKA has shown successful outcomes with regards to pain relief and function with 96.4% implant survival and 94.9% good or excellent outcomes. Due to lower demands, early rehabilitation, less morbidity, and relative short life expectancy, UKA can successfully manage TCOA in the octogenarians. PMID:24133305
Prepubertal diagnosis of Klinefelter syndrome due to penoscrotal malformations: Case report and review of literature.
Hodhod, Amr; Umurangwa, Florence; El-Sherbiny, Mohamed
We report a case of 4 months old infant diagnosed as Klinefelter syndrome associated with perineal hypospadias, severe ventral chordee and complete penoscrotal transposition. A review of previous reported cases was carried out. Penoscrotal malformations at birth are very rare in Klinefelter syndrome. Awareness of the current standard indications of Karyotyping can help early detection of these cases. PMID:26029310
Prepubertal diagnosis of Klinefelter syndrome due to penoscrotal malformations: Case report and review of literature
Hodhod, Amr; Umurangwa, Florence; El-Sherbiny, Mohamed
We report a case of 4 months old infant diagnosed as Klinefelter syndrome associated with perineal hypospadias, severe ventral chordee and complete penoscrotal transposition. A review of previous reported cases was carried out. Penoscrotal malformations at birth are very rare in Klinefelter syndrome. Awareness of the current standard indications of Karyotyping can help early detection of these cases.
30 CFR 1210.53 - When are my royalty reports and payments due?
Code of Federal Regulations, 2012 CFR
...my royalty reports and payments due? (a) Completed Forms MMS-2014 for royalty payments and the associated payments are...also ¦ 1218.50 of this chapter). (b) Completed Forms MMS-2014 for rental payments, where applicable, and the...
First report of an infant botulism case due to Clostridium botulinum type Af.
de Jong, Laura I T; Fernßndez, Rafael A; Pareja, Virtudes; Giaroli, Gabriel; Guidarelli, Sergio R; Dykes, Janet K; L·quez, Carolina
Most infant botulism cases worldwide are due to botulinum toxin types A and B. Rarely, Clostridium botulinum strains that produce two serotypes (Ab, Ba, and Bf) have also been isolated from infant botulism cases. This is the first reported case of infant botulism due to C. botulinum type Af worldwide. PMID:25502535
Vaccine risk assessment in children with a referred reaction to a previous vaccine dose: 2009¢2011 retrospective report at the Bambino GesuÆ children hospital, Rome, Italy
Background During the last century, mass vaccination programs have achieved considerable success across the world in immunizing against several serious infectious diseases. However, vaccinations are threatened by their own success after results have been obtained: the more the incidence of potentially devastating diseases decreases, thanks to the success of vaccination programs, the more public attention shifts towards real or alleged ōside effectsö of vaccines. Methods We analyze the experience of 153 children with ōreaction to a previous vaccine doseö continuing the vaccination protocol in the safe environment of the Center for risk vaccination at the Bambino Ges∙ ChildrenÆs Hospital IRCCS in Rome, from 2009 to 2011. Results To assess the suitability for vaccination, a specialized pre-vaccination advice and a skin prick test (SPT) was undergone, according to WoodÆs guideline; 151 children were SPT negative and full vaccine was administered. Of the 153 children examined just 13 had symptoms suggestive of IgE-mediated reaction-type reactions with angioedema manifestations. Among them, 2 had positive STP, which required alternative measures of administration of the vaccine. No cases of post vaccination reaction was reported and no vaccination program was stopped due to a severe reaction. Conclusions Inadequate levels of immunization against infectious diseases remain a significant problem for public health. However, the reasons for incomplete vaccination and non-adoption of vaccination services are manifold. To maintain public confidence in vaccines, advanced immunization programs must include activities for monitoring the safety of the vaccine at the individual level and pursuing specialized counseling pre-and post-vaccination for those at risk. Our results underlined a gap between true and referred adverse reactions and are consistent with vaccine safety. Anyway, a continuous assessment of the risks and benefits of vaccination is required and the results must be disclosed in order to strengthen confidence in the existing and in the new immunization programs. PMID:24684865
Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature
Zhang, Xiaofei; Shi, Haiyan; Chen, Xiaoduan
Epithelioid trophoblastic tumor (ETT) is a rare trophoblastic tumor originating from chorionic-type intermediate trophoblasts (ITs). It is usually associated with a prior gestational event. We present a 44-year-old woman who had unusual pregnancy related history. The patient received her second spontaneous abortion at the age of 25 years and had suffered from choriocarcinoma in left board ligament at the age of 29 years. She admitted no more treatment after 3 courses of multiagent chemotherapy when serum ?-hCG returned to normal. Then she had Full-term delivery, induced abortion at the ages of 32, 33 years. The patient had high serum levels of beta-human chorionic gonadotropin (6587 IU/L). Microscopically, the tumor was composed of mainly mononuclear tumor cells, grew in cords, nests, and sheets within which were aggregates of hyaline material. Most were with distinct cell borders, eosinophilic cytoplasm. Immunohistochemical staining revealed strong diffuse reactivity for cytokeratins (AE1/AE3, CK18), P63, focal reactivity for beta-human chorionic gonadotropin, human placental lactogen, and inhibin-alpha. The Ki-67 index was 77%. The histological and immunohistochemical features were characteristic of epithelioid trophoblastic tumor. This is the first reported case of these two gestational trophoblastic tumor happened on one person with the intervening normal pregnancy. PMID:25550880
Cluster Report or Survey Description Date due to IEA Responsible person(s) Comments Summer Activity Report
Fernandez, Eduardo
Cluster Report or Survey Description Date due to IEA Responsible person(s) Comments Summer Activity 10, 2014, Assignment Year 2014 made available by IEA for reporting Student Satisfaction Survey Survey Survey Survey of graduating seniors Online survey distributed to graduating seniors Summer 2013 - June 13
Peripheral precocious puberty due to inadvertent exposure to testosterone: case report and review of the literature.
Martinez-Pajares, Jose David; Diaz-Morales, Olga; Ramos-Diaz, Juan Carlos; Gomez-Fernandez, Enrique
Sexual development in children due to exogenous androgen exposure is rare and sparsely reported. In this paper, we present a new case of peripheral precocious puberty of exogenous origin in an 18-month-old boy due to inadvertent exposure to a testosterone gel used by his father as hormonal replacement therapy. We also review other cases in the literature. Most of these cases are due to a secondary exposure to androgen topical preparations, such as gels or creams. We highlight the value of the knowledge of the existence of these preparations to the paediatrician, given the increasingly widespread use and production of adverse effects from inadvertent contact, especially in children. PMID:23426834
Post-Kidney Transplantation Iliac Artery Stenosis due toIatrogenic Injury: Case Report
Khankan, Azzam Anwar, E-mail: firstname.lastname@example.com; Maeda, Munehiro; Osuga, Keigo; Murakami, Takamichi; Nakamura, Hironobu [Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Department of Radiology (Japan)
We report a case of left external iliac artery lesions as a complication of post-kidney transplantation due to vascular clamp application injury. The lesions were proximal stenosis and distal occlusion just near the graft anastomosis site and they were diagnosed incidentally during the embolization for arteriovenous fistula. Angiography confirmed the diagnosis and it was managed successfully by percutaneous interventional techniques.
Ladder Inspections Due to recent information, lessons learned, and accident reports from across the
Quigg, Chris
Defective locks that do not seat properly when ladder is extended Frayed or worn rope Single section laddersLadder Inspections Due to recent information, lessons learned, and accident reports from across the DOE complex, emphasis needs to be placed on the importance of inspecting ladders, both portable
Severe Mitral Regurgitation due to Traumatic Anterolateral Papillary Muscle Rupture: A Case Report
Lee, Chul Ho; Lee, Sub; Jang, Jae Seok
A 29-year-old man was admitted for abrupt dyspnea and hemoptysis. An echocardiogram revealed severe mitral regurgitation due to papillary muscle rupture for which an emergency mitral valve replacement operation was performed 4 days after admission. Herein, we report our experience with this case along with a review of the literature. PMID:23275923
Unique fatality due to claw injuries in a tiger attack: a case report.
Pathak, Hrishikesh; Dixit, Pradeep; Dhawane, Shailendra; Meshram, Satin; Shrigiriwar, Manish; Dingre, Niraj
This paper describes a unique case of a fatal tiger attack in the wild. In the present case, a tiger fatally mauled a 34-year-old female with its claws, instead of the usual mechanism of killing by the bite injury to the neck. The autopsy revealed multiple fatal and non-fatal injuries caused by the tiger claws. The characteristic injuries due to the tooth impacts were absent as the teeth of the offending tiger were either fallen or non-functional. To the best of our knowledge, probably this rare case would be the first reported human fatality due to the tiger claw injuries in the world. The purpose of the present article is to highlight the fatal injuries due to the tiger claws, as the claw-induced fatal injuries in a tiger attack are not reported in the medico-legal literature. Moreover, this report would be an illustrative one for differentiation between the fatal injuries due to the claws and tooth impacts in a tiger attack. Furthermore, the present report establishes the importance of the tiger claws as a source of fatal injuries in a tiger attack. PMID:25082732
Operation Sun Beam, Shot Small Boy. Project Officer's report - Project 6. 9. Correlation of present and previous electric-field measurements
Reno; Fowles, H.M.
On most previous nuclear detonations, signatures and quantitative measurements of the electric-field signals associated with the detonations was obtained at distances such that normal radiation field characteristics apply. On Small Boy, measurements were made from stations located much closer in, such as to be inside, on the boundary of and just outside the limits of the ionized sphere created by the nuclear burst. The electric-field characteristics in these regions were unknown. In the hope of providing continuity from the region of the unknown into the reasonably well-understood region of the radiation field, this project was requested to make the typical radiation-field type of measurement that had been made on previous detonations. This report covers the signature characteristics and quantitative measurements of the electric-field signal from Small Boy as seen from outside the immediate region of theoretical generating mechanism.
Chronic obstructive uropathy due to uretero-inguinal hernia: A case report
Won, Andy Chuk Moon; Testa, Gerard
INTRODUCTION Inguinal hernia in men is common but uretero-inguinal hernia is very rare. PRESENTATION OF CASE A 85-year-old obese man presented with chronic obstructive uropathy with previous renal ultrasound showing bilateral enlarged kidneys and hydronephrosis. The medical history revealed a 3-year history of a noticeable bilateral partial reducible inguinoscrotal herniae associated with urinary symptoms. Progress CT scan showed very large inguinal herniae, which were predominantly fat-containing with the ureters herniated, and both kidneys were displaced inferiorly. DISCUSSION Uretero-inguinal hernia in patients with native kidneys is rare, but cases of renal failure secondary to uretero-inguinal hernia have also been reported previously in the literature with two anatomical variations have been reported ¢ paraperitoneal and extraperitoneal types. Endourological and surgical procedures are rarely straight-forward because of tortuosity of the herniated ureter. CONCLUSION Although uretero-inguinal hernia is rare, it can be the cause of chronic renal impairment. PMID:22609811
Graduate Council Important Dates (2013-2014) Agenda Items Due GC Meeting Report to Faculty Senate Faculty Senate Meeting
Graduate Council Important Dates (2013-2014) Fall 2013 Agenda Items Due GC Meeting Report Agenda Items Due GC Meeting Report to Faculty Senate Faculty Senate Meeting 17 December 2013* 2 January May 2014 15 April 2014 1 May 2014 28 May 2014 9 June 2014 Summer 2014 Agenda Items Due GC Meeting
Cerebral Phaeohyphomycosis due to Cladophialophora bantiana ¢ A Case Report and Review of Literature from India
Chhina, Deepinder Kaur; Kaushal, Vandana; Kaushal, Rakesh Kumar; Singh, Jasdeep
Cerebral phaeohyphomycosis is a rare disease caused by dematiaceous fungi. It has poor prognosis irrespective of the immune status of the patient. Cladophialophora bantiana is the most commonly isolated species. We report a case of multiple brain abscesses caused by C. bantiana in an immune competent patient. The diagnosis was based on CT scan of head, direct examination and culture of the aspirate from the abscess. Despite complete surgical resection of the abscesses and antifungal therapy with amphotericin B and voriconazole the patient could not be saved. All the cases of cerebral phaeohyphomycosis due to this rare neurotropic fungus reported from India between 1962 and 2009 have also been reviewed. PMID:24959445
Intestinal obstruction due to migration of a thermometer from bladder to abdominal cavity: A case report
Nie, Jing; Zhang, Bo; Duan, Yan-Chao; Hu, Yue-Hua; Gao, Xin-Ying; Gong, Jian; Cheng, Ming; Li, Yan-Qing
Intraperitoneal foreign bodies such as retained surgical instruments can cause intestinal obstruction. However, intestinal obstruction due to transmural migration of foreign bodies has rarely been reported. Here, we report a case of intestinal obstruction due to a clinical thermometer which migrated from the bladder into the abdominal cavity. A 45-year-old man was admitted to our hospital with a one-year history of recurrent lower abdominal cramps. Two days before admission, the abdominal cramps aggravated. Intestinal obstruction was confirmed with upright abdominal radiography and computerized tomography scan which showed dilation of the small intestines and a thermometer in the abdominal cavity. Then laparotomy was performed. A scar was observed at the fundus of the bladder and a thermometer was adhering to the small bowels and mesentery which resulted in intestinal obstruction. Abdominal cramps were eliminated and defecation and flatus recovered soon after removal of the thermometer. PMID:24605042
Human infections due to Salmonella Blockley, a rare serotype in South Africa: a case report
Background Infections due to nontyphoidal Salmonella have increased worldwide over the last couple of decades. Salmonella enterica serotype Blockley (Salmonella Blockley) infections is associated with chickens and is a rarely isolated serotype in human infections in most countries. Case presentation We report a case of human infections due to Salmonella Blockley in KwaZulu-Natal, South Africa in 2011. Three African males (aged 4, 14 and 16) presented to a clinic with diarrhoea, stomach cramps and headache. They started experiencing signs of illness a day after they consumed a common meal, consisting of meat, rice and potatoes. Stool specimens from the patients cultured Salmonella Blockley. The strains showed an indistinguishable pulsed-field gel electrophoresis pattern. Conclusion This is the first recorded case of human infections due to Salmonella Blockley in South Africa. PMID:23050633
Oral mucosal ulceration due to ferrous sulphate tablets: report of a case.
Jones, Terry A; Parmar, Satyesh C
Recurrent oral ulceration due to underlying iron-deficiency anaemia is already recognized. However, this case report describes a 78-year-old lady who developed severe ulceration of the tongue and floor of the mouth as a result of the treatment of iron-deficiency anaemia with ferrous sulphate tablets. Withdrawal of the ferrous sulphate tablets and replacement with ferrous fumarate syrup led to resolution of the lesion. PMID:17209540
Acute coronary artery occlusion likely due to thrombus occurring during coronary angiography: report of a case.
Bonafede, N; Schwartz, L
Twenty-five years ago, fatalities due to acute thrombotic coronary occlusion occurring during coronary angiography were reported not infrequently, but are thought to have been eliminated by changes in technique and equipment. We present a case with documentation of a normal coronary arterial tree just before the time of an abrupt occlusion, which had the angiographic features of clot. The likely source of the thrombus was the arterial sheath. Measures for prevention of this complication are discussed. PMID:9554781
Case report: imaging and surgical treatment of a snapping hip due to ischiofemoral impingement
Adam Mohsan Ali; Duncan Whitwell; Simon J. Ostlere
An association between hip pain and quadratus femoris MRI abnormality with concurrent narrowing of the ischiofemoral space\\u000a has been reported in a number of patients to date, raising the possibility that the muscular damage observed is due to ischiofemoral\\u000a impingement [1]. Possible impingement has been noted primarily in middle-aged females either with or without a history of trauma or surgery,
Hydroxyapatite ceramic-coated femoral components in young patients followed up for 17 to 25 years: an update of a previous report.
Syed, M A; Hutt, N J; Shah, N; Edge, A J
This study reports the results of 38 total hip arthroplasties (THAs) in 33 patients aged <Ā50Āyears, using the JRI Furlong hydroxyapatite ceramic (HAC)-coated femoral component. This represents an update of previous reports of the same cohort at ten and 16 years, which were reported in 2004 and 2009, respectively. We describe the survival, radiological and functional outcomes at a mean follow-up of 21 years (17 to 25). Of the surviving 34 THAs, one underwent femoral revision for peri-prosthetic fracture after 21 years, and one patient (one hip) was lost to follow-up. Using aseptic loosening as the end-point, 12 hips (31.5%) needed acetabular revision but none needed femoral revision, demonstrating 100% survival (95% confidence interval 89 to 100). In young patients with high demands, the Furlong HAC-coated femoral component gives excellent long-term results. Cite this article: Bone Joint J 2015;97-B:749-54. PMID:26033053
[Metatropic dysplasia in a girl with c.1811_1812delinsAT mutation in exon 11 of the TRPV4 gene not previously reported].
Cammarata-Scalisi, Francisco; Matysiak-Scholze, Uta; Heinze, Jessica; Barrera, Albaro; Lacruz-Rengel, MarĒa Angelina; Bracho, Ana; Guerrero, Yudith
Metatropic dysplasia is a skeletal disorder with clinical heterogeneity, characterized by craniofacial dysmorphy including frontal bossing and midface hypoplasia, short trunk,progressive kyphoscoliosis and shortened limbs. The TRPV4 gene is located on 12q24.11, coding a cation channel with nonselective permeability to calcium; it is expressed and involved in many physiological processes through responses to different stimuli. Over 50 mutations in TRPV4 have been described. We present a seven months old girl with heterozygous mutation c.1811_1812delinsAT; p.I604N in intron 11 not previously reported in the TRPV4 gene and with clinical findings compatible with metatropic dysplasia. PMID:25622169
Case report: imaging and surgical treatment of a snapping hip due to ischiofemoral impingement.
Ali, Adam Mohsan; Whitwell, Duncan; Ostlere, Simon J
An association between hip pain and quadratus femoris MRI abnormality with concurrent narrowing of the ischiofemoral space has been reported in a number of patients to date, raising the possibility that the muscular damage observed is due to ischiofemoral impingement. Possible impingement has been noted primarily in middle-aged females either with or without a history of trauma or surgery, and associated snapping of the hip is a rarely described feature. We report here on a 17-year-old girl who presented with post-traumatic hip pain; she later developed evidence of ischiofemoral narrowing and quadratus femoris edema on MRI in addition to an audible snapping. Surgical resection of the lesser trochanter was performed, relieving both her hip pain and the snapping. To our knowledge, this is the first reported case of non-iatrogenic ischiofemoral impingement with surgical confirmation. The diagnosis of ischiofemoral impingement should be considered in patients complaining of a snapping hip. PMID:21207021
First report of OPA1 screening in Greek patients with autosomal dominant optic atrophy and identification of a previously undescribed OPA1 mutation
Koutsodontis, George; Tsilimbaris, Miltiadis; Fitsios, Athanasios; Chrousos, Georgia
Purpose To describe the genotype¢phenotype correlation in four Greek pedigrees with autosomal dominant optic atrophy (ADOA) and OPA1 mutations. Methods Seven patients from four unrelated families (F1, F2, F3, F4) were clinically assessed for visual acuity, color vision, ptosis, afferent pupillary defects, and visual fields and underwent orthoptic assessment, slit-lamp biomicroscopy, and fundus examination to establish their clinical status. Genomic DNA was extracted from peripheral blood samples from all participants. The coding region (exons 1¢28), including the intron-exon boundaries of the OPA1 gene, was screened in the probands of the four families, as well as in seven additional family members (four affected and three unaffected) with PCR and direct DNA sequencing. Results All patients presented bilateral decrease in best-corrected visual acuity and temporal pallor of the optic disc. The visual fields of the adult patients showed characteristic scotomata. Other signs were present in some patients such as decreased color discrimination and a gray crescent within the neuroretinal rim. After the OPA1 gene was sequenced, a previously undescribed heterozygous splice-site mutation c.784¢1G>T in intron 7 was detected in family F2. In families F1, F3, and F4, a previously reported in-frame deletion c.876_878delTGT/p.(Val294del), the frameshift c.2366delA/p.(Asn789Metfs*11), and splice-site c.1140+5G>C mutations were detected, respectively. Conclusions This is the first report of molecular characterization of Greek patients with ADOA. Our findings provide additional information regarding the genotype-phenotype correlation and establish the role of the OPA1 gene in Greek patients with ADOA. PMID:24883014
Allergic contact dermatitis mimicking angioedema due to paraphenylendiamine hypersensitivity: a case report.
Tukenmez Demirci, Gulsen; Kivanc Altunay, Ilknur; Atis, Guldehan; Kucukunal, Asli
Active sensitization to paraphenylendiamine (PPD) and related compounds from temporary black henna tattoos has become an epidemic in the recent years. Hair dyes also include PPD like black henna tatoos which cause allergic contact dermatitis. Skin lesions of allergic contact dermatitis from PPD are mostly seen as an exudative erythema, an erythema multiforme-like eruption or a bullous contact dermatitis. We, herein, report a 27 year-old woman with an angioedema-like reaction occurring after the first exposure to hair dye who was unaware of being previously sensitized to PPD from black henna tattoo. PMID:22181557
Hypocalcemia and hypokalemia due to hyperventilation syndrome in spinal anesthesia -A case report-
Lee, Soo Kyung; Chung, Ji Hoon; In, Chi Bum
Hyperventilation syndrome (HVS) often occurs under stressful conditions, and has been reported during or after anesthesia and operation. HVS, characterized by multiple somatic symptoms and electrolyte imbalances induced by inappropriate hyperventilation, should be managed as an emergency. We report a rare case of HVS during spinal anesthesia. The patient was a previously healthy 51-year-old female without psychogenic conditions. During spinal anesthesia for lower extremity surgery, the patient complained of nausea, headache, paresthesia in the upper extremities and perioral numbness. We found carpal spasm in both hands and flattening of T wave on electrocardiogram (ECG). Emergent arterial blood gas analysis (ABGA) revealed markedly decreased PaCO2, hypocalcemia and hypokalemia. We managed the patient with verbal sedation, electrolytes replacement therapy and closed mask inhalation. HVS subsided gradually. We conclude that monitoring for possible HVS during anesthesia is very important for patient safety. PMID:22220232
Mutational analysis of TSC1 and TSC2 in Japanese patients with tuberous sclerosis complex revealed higher incidence of TSC1 patients than previously reported.
Niida, Yo; Wakisaka, Akiko; Tsuji, Takanori; Yamada, Hiroshi; Kuroda, Mondo; Mitani, Yusuke; Okumura, Akiko; Yokoi, Ayano
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by multiple hamartias and hamartomas involving throughout the body. To date, many TSC1 and TSC2 mutations have been reported all over the world, however, few TSC mutation studies have been performed in the Japanese population, and genetic characteristics of Japanese TSC patients are not yet clear. In this study, we analyzed TSC1 and TSC2 in 57 Japanese patients with TSC (8 familial and 49 sporadic; 46 definite and 11 suspect TSC) and identified 31 mutations including 11 TSC1 mutations (two familial and nine sporadic; all definite TSC) and 20 TSC2 mutations (2 familial and 18 sporadic; 19 definite and 1 suspect TSC). We also reviewed all Japanese TSC mutations previously reported. Our study demonstrates significantly higher incidence (P=0.007) of TSC1 mutations among sporadic TSC patients in the Japanese population compared with US and European studies. No differences emerged in mutation distributions and types in precedent studies, excepting low frequency of the TSC2 nonsense mutation. Comparing clinical manifestations, developmental delay and/or mental retardation were milder in TSC1 patients than TSC2 patients for its frequency (P=0.032) and severity (P=0.015); however, no other symptoms were clearly different. PMID:23389244
Alumina-on-alumina total hip arthroplasty: a concise follow-up, at a minimum of ten years, of a previous report.
Lee, Young-Kyun; Ha, Yong-Chan; Yoo, Jeong Joon; Koo, Kyung-Hoi; Yoon, Kang Sup; Kim, Hee Joong
We previously reported the five-to-six-year results of the use of third-generation alumina-on-alumina bearings in a consecutive series of 100 primary cementless total hip arthroplasties. This report presents the longer-term outcomes of these same bearings, at a minimum of ten years postoperatively. Eighty-six of eighty-eight hips available for the study retained the original bearings at the time of the latest follow-up. Thirteen hips were associated with noise, and six hips demonstrated fretting of the femoral neck on radiographs. Two hips required a change of the bearings because of a ceramic head fracture. The ten-year survival rate of the alumina-on-alumina total hip prostheses, with revision of any implant for any reason as the end point, was 99.0%. On the basis of those results, we concluded that the rate of survival of primary cementless total hip prostheses with third-generation alumina-on-alumina bearings is excellent at ten years. However, the risk of ceramic fracture, noise, and impingement between the metal neck and the ceramic liner should be a concern to surgeons, and patients should be informed of these risks before surgery. PMID:20660234
Intussusception due to inflammatory fibroid polyp: A case report and comprehensive literature review
Akbulut, Sami
AIM: To give an overview of the literature on intussusception due to inflammatory fibroid polyp (IFP). METHODS: We present a new case of ileal intussusception due to IFP and a literature review of studies published in English language on intussusception due to IFP, accessed via PubMed and Google Scholar databases. For the search, the keywords used were: intussusception, IFP, intussusception and IFP, intussusception due to IFP, and IFP presenting as intussusception. The search covered all articles from 1976 to November 2011. RESULTS: We present a 38-year-old woman who was admitted 10 d after experiencing abdominal pain, vomiting, and nausea. Ultrasonography demonstrated small bowel intussusception. An ileal intussusception due to a mass lesion 50 cm proximal to the ileocecal junction was found during laparotomy. Partial ileal resection and anastomosis were performed. A diagnosis of ileal IFP was made based on the immunohistochemical findings. In addition, a total of 56 reports concerning 85 cases of intussusception due to IFP meeting the aforementioned criteria was included in the literature review. The patients were aged 4 to 81 years (mean, 49?▒?16.2 years); 44 were women (mean, 51.8?▒?14.3 years) and 41 were men (mean, 46?▒?17.5 years). According to the location of the IFP, ileal intussusception was found in 63 patients, while 17 had jejunal, three had colonic, and two had ileojejunal intussusception. CONCLUSION: Although IFPs are rare and benign, surgery is the only solution in case of intestinal obstruction. Differential diagnosis should be made via immunohistochemical examination. PMID:23155316
Radicular dysfunction due to spinal deformities in Marfan syndrome at older age: three case reports.
Voermans, N C; Hosman, A J; van Alfen, N; Bartels, R H; de Kleuver, M; op den Akker, J W; van Engelen, B G
Marfan syndrome is a inherited connective tissue disorder due to mutations in fibrillin-1. It presents with cardiovascular, ocular, skeletal, pulmonary and dural signs and symptoms. Some of the symptoms of later onset are those associated with scoliosis and dural ectasia. This is the enlargement of the neural canal especially in the lower lumbar and sacral region and occurs in over 90% of Marfan patients. We here report three patients with lumbar and/or sacral radiculopathy due to (kypho)scoliosis and dural ectasia with spinal meningeal cysts. The pain, muscle weakness, muscle atrophy, and sensory disturbances illustrate the severe neurological complications which may occur in Marfan syndrome, especially at later age. Awareness of these complications and development of management protocols is essential since life expectancy of Marfan patients has increased. Marfan syndrome might gradually become recognized as an inherited connective tissue disorder with potentially severe neurological complications during ageing. PMID:19879983
Magnetic resonance imaging findings in patients with delusional disorder due to diffuse cerebrovascular disease: a report of seven cases.
Su, K P; Hsu, C Y; Hsieh, S C; Shen, W W
Delusions associated with cerebrovascular diseases have been sporadically reported. Although both psychiatrists and neurologists attempted to link delusions with anatomical locations of the brain lesion, comorbid psychiatric and neurological disorders make the interpretation of delusions difficult. The purpose of the present paper is to report the clinical features and magnetic resonance imaging (MRI) characteristics in patients with delusional disorder due to diffuse cerebrovascular diseases, and to redefine the concept of 'vascular delusion'. The clinical features and MRI findings were reviewed retrospectively in a series of seven patients with 'delusional disorder due to cerebrovascular disease' as defined in Diagnostic and Statistical Manual of Mental Disorders (DSMIV). The average age of onset is 64. No patient had a prior personal or family history of major psychiatric illness. The illness is presented as acute, subacute or stepwise course. Hypertension was present in all patients. Two had diabetes mellitus, and one had atrial fibrillation. Three had clinical evidence of previous cerebrovascular attacks, only one showed minor neurological deficits. Three had diffuse cortical slow wave in electroencephalogram. No patient had significant cognitive impairment but had multiple cortical and subcortical cerebrovascular lesions in MRI, with white-matter lesions (WML) in bilateral frontal areas. Delusional disorder due to diffuse cerebrovascular change is characterized by late-onset, stepwise course, and comorbid medical and neurological diseases. The results of vascular changes in the present study did not establish a cause-effect relationship and should be considered as multifactorial in pathogenesis. The findings suggested the hypothesis of neural circuit theory. Further studies in larger numbers of patients and newer neuroimaging techniques are needed to expand the knowledge learned from these findings. PMID:11285090
Osteomyelitis due to Bacillus cereus in an adolescent: case report and review.
Schricker, M E; Thompson, G H; Schreiber, J R
Non-anthracis Bacillus species associated with clinical infections are usually dismissed as contaminants or nonpathogens. As opportunists, however, Bacillus organisms can cause significant systemic infections including bacteremia, endophthalmitis, and pneumonia. Osteomyelitis with non-anthracis Bacillus organisms has been described in adults, although to our knowledge it has been described only once in a child. We report a case of chronic osteomyelitis due to Staphylococcus aureus and superinfection with Bacillus cereus in a 13-year-old adolescent. A Bacillus isolate should be considered a true pathogen in children with chronic osteomyelitis who have a poor clinical response to antistaphylococcal therapy. PMID:8086544
Death due to combined intake of ethanol and toluene: a case report.
G³rses, Murat Seradar; T³rkmen, Nursel; Eren, Bulent; Ūetin, Selcuk; G³ndo?mu?, Umit Naci
Toluene is a commonly used volatile organic chemical in industry and is the most often chosen illicit substance among volatile substance abusers. Studies involving healthy volunteers suggest that ethanol consumption inhibits toluene metabolism, thus increasing its blood levels. In this study, a lethal case of combined ethanol consumption and toluene inhalation has been reported. Our case was a 30-year-old male who had used volatile substance for 15 years. The autopsy revealed no abnormal findings. Toxicological analysis revealed alcohol and toluene in the blood and the cause of death was considered as toxicity due to acute combined intake of alcohol and toluene. Lethal combined ethanol and toluene intake is rarely reported in the literature. Experimental studies indicate that toluene increases the risk of ethanol dependence and each substance increases the toxic effects of the other. PMID:25705313
Acute Compartment Syndrome of the Foot due to Infection After Local Hydrocortisone Injection: A Case Report.
Dumbre Patil, Sampat; Dumbre Patil, Vaishali; Abane, Sachin; Luthra, Rohit; Ranaware, Abhijit
High-energy trauma associated with calcaneal fracture or Lisfranc fracture dislocation and midfoot crushing injuries are known causes of compartment syndrome in the foot. Suppurative infection in the deep osseofascial compartments can also cause compartment syndrome. We describe the case of a 29-year-old female who had developed a suppurative local infection that resulted in acute compartment syndrome after receiving a local hydrocortisone injection for plantar fasciitis. We diagnosed the compartment syndrome, and fasciotomy was promptly undertaken. After more than 2 years of follow-up, she had a satisfactory functional outcome without substantial morbidity. To our knowledge, no other report in the English-language studies has described compartment syndrome due to abscess formation after a local injection of hydrocortisone. The aim of our report was to highlight this rare, but serious, complication of a routine outpatient clinical procedure. PMID:24838218
Evidence Report: Risk of Crew Adverse Health Event Due to Altered Immune Response
NASA Technical Reports Server (NTRS)
Crucian, Brian; Sams, Clarence F.
The Risk of Crew Adverse Health Event Due to Altered Immune Response is identified by the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) as a recognized risk to human health and performance in space. The HRP Program Requirements Document (PRD) defines these risks. This Evidence Report provides a summary of the evidence that has been used to identify and characterize this risk. It is known that human immune function is altered in- and post-flight, but it is unclear at present if such alterations lead to increased susceptibility to disease. Reactivation of latent viruses has been documented in crewmembers, although this reactivation has not been directly correlated with immune changes or with observed diseases. As described in this report, further research is required to better characterize the relationships between altered immune response and susceptibility to disease during and after spaceflight. This is particularly important for future deep-space exploration missions.
[Chronic manganese intoxication due to methcathinone (ephedron) abuse: a case report].
Yildirim, Ejder Akg³n; E?sizo?lu, Altan; K÷ksal, Ayhan; Do?u, Basri; Bayba?, Sevim; G÷kalp, Peykan
Known as an occupational disease, chronic manganese intoxication is recently being observed among abusers of psychoactive substances. Methcathinone hydrochloride is obtained by combining ephedrine/pseudoephedrine and potassium permanganate. Various neuropsychiatric symptoms have been reported among Efedron users. Our patient is a 29 year old male, who was referred to our hospital from a state general hospital with a diagnosis of Conversion Disorder. He was hospitalized and preliminary diagnoses of Facititous Disorder, Conversion Disorder, Psychiatric Disorder due to a General Medical Condition and Antisocial Personality Disorder. He was abstinent from any substance for five years upon referral to our hospital and had a history of methcathinone abuse for 4.5 years. The backache dated back to 6 years ago and a disturbance of gait was added to the clinical picture. A speech disturbance, falling while walking downhill and walking on tiptoe were added in the last 2-3 years. In the neurological examination, extrapyramidal system findings, gait disturbance and the report on use of manganese compunds were found. The setting was changed from psychiatric ward to neuorology ward and evaluated by consultant neurologist. The case was diagnosed as ?Manganese Intoxication'. The aim of this report is to demonstrate and emphasize the importance of questioning the presence of manganese compounds in case of history of substance abuse. Other areas of interest are the shortage of data on the intravenous use of manganese and the cases reported in the literature coming from the former Soviet Union. PMID:19757228
First Reported Case of Reactive Airway Dysfunction Syndrome in a Laborer Due to Porcelain Tile Dust
Arif, Tasleem; Malik, Javid Ahmad; Shoib, Sheikh
Reactive airway dysfunction syndrome (RADS) is a type of non-immunologically mediated asthma-like disease. It usually occurs after a massive exposure to an irritating substance in the atmosphere in the form of smoke, fumes, gases, and vapor. Unlike bronchial asthma, there is no latency to the symptoms seen in RADS. A number of agents are known to cause RADS, but tile dust, as an etiological agent, has not been previously reported. We report a 45-year-old male laborer, who presented with an acute onset of cough, chest tightness, breathlessness, and audible wheeze after his first time exposure to porcelain tile dust within 5 hours of exposure. Lab tests, including, chest X-ray, electrocardiogram, air blood gas analysis, and serum IgE, were unremarkable. Spirometry showed a mild obstruction [forced expiratory volume in 1 second (FEV1)=72% of predicted], while the bronchodilator reversibility test was significant(14% increase in FEV1 above the baseline).Bronchial biopsy revealed a chronic inflammatory reaction with lymphocytic and plasma cell infiltration and more importantly a striking absence of eosinophils. To the best of our knowledge, this is the first reported case of RADS as a result of exposure to tile dust (porcelain ceramics). PMID:23825894
First reported case of reactive airway dysfunction syndrome in a laborer due to porcelain tile dust.
Arif, Tasleem; Malik, Javid Ahmad; Shoib, Sheikh
Reactive airway dysfunction syndrome (RADS) is a type of non-immunologically mediated asthma-like disease. It usually occurs after a massive exposure to an irritating substance in the atmosphere in the form of smoke, fumes, gases, and vapor. Unlike bronchial asthma, there is no latency to the symptoms seen in RADS. A number of agents are known to cause RADS, but tile dust, as an etiological agent, has not been previously reported. We report a 45-year-old male laborer, who presented with an acute onset of cough, chest tightness, breathlessness, and audible wheeze after his first time exposure to porcelain tile dust within 5 hours of exposure. Lab tests, including, chest X-ray, electrocardiogram, air blood gas analysis, and serum IgE, were unremarkable. Spirometry showed a mild obstruction [forced expiratory volume in 1 second (FEV1)=72% of predicted], while the bronchodilator reversibility test was significant(14% increase in FEV1 above the baseline).Bronchial biopsy revealed a chronic inflammatory reaction with lymphocytic and plasma cell infiltration and more importantly a striking absence of eosinophils. To the best of our knowledge, this is the first reported case of RADS as a result of exposure to tile dust (porcelain ceramics). PMID:23825894
Cloning and nucleotide sequence analysis of psaA, the Streptococcus pneumoniae gene encoding a 37-kilodalton protein homologous to previously reported Streptococcus sp. adhesins.
Sampson, J S; O'Connor, S P; Stinson, A R; Tharpe, J A; Russell, H
Gene psaA, which encodes the Streptococcus pneumoniae 37-kDa protein, was cloned in Escherichia coli, and its complete nucleotide sequence was determined. Analysis of the sequence of the 2.4-kb cloned fragment revealed three open reading frames (ORFs). ORF2, which is 933 bp long, was identified as psaA. The two other ORFs identified flank psaA. ORF1, located upstream of psaA, is 836 nucleotides long and encodes a protein with a calculated molecular mass of 29,843 Da. The sequence for ORF3, located downstream of psaA, was only partially determined. Northern (RNA) blot analysis of pneumococcal RNA suggests that psaA is transcribed as part of a polycistronic message. Analysis of the primary structure of the protein encoded by this gene indicated significant similarity to two previously reported streptococcal proteins, SsaB (80% similarity) and FimA (92.3% similarity), from S. sanguis and S. parasanguis, respectively. These two homologous proteins have been shown to be associated with bacterial adhesion, and the possibility of a similar role for PsaA is hypothesized. Images PMID:7505262
Months since Previous Mammogram
The number of mammograms performed nine months after the previous mammogram is small. The chart rises sharply, with nearly 250,000 mammograms performed 12 months after the previous one, then drops sharply after that. At both the 11- and 13-month marks, there were over 100,000 mammograms performed. The chart rises again to a smaller peak, still below 50,000 mammograms, at the 24-month mark, then tapers off, with still smaller peaks at 36, 48, and 60 months.
Dropped head syndrome due to myogenic atrophy - a case report of surgical treatment.
Zenmyo, Michihisa; Abematsu, Masahiko; Yamamoto, Takuya; Ishidou, Yasuhiro; Komiya, Setsuro; Ijiri, Kosei
We report a case of a 69-year-old man with dropped head syndrome associated with isolated neck extensor myopathy (INEM). Over a period of 2 years, he exhibited progressive inability to lift his chin off his chest, resulting in the dropped head position that impaired his activities of daily living. He had a disturbed gait with severe imbalance of spinal alignment. Computed tomography revealed osseous contracture of cervical vertebral bodies in flexed position. Anterior combined posterior reconstruction surgery yielded a successful outcome in his activities of daily living, including his walking balance of spinal alignment. Pathologic study confirmed myogenic atrophy in the cervical extensor muscles. We suggest that consideration for surgical management should be given to dropped head syndrome especially due to INEM. PMID:21247445
Ventricular fibrillation due to coronary spasm at the site of myocardial bridge -A case report-
Choi, Jung Gi; Lee, Cheol Seung; Choi, June Seog
Myocardial bridge is a congenital anomaly characterized by narrowing of some of the epicardial coronary arterial segments running in the myocardium during systole. Occasionally, the compression of a coronary artery by a myocardial bridge can be associated with the clinical manifestations of myocardial ischemia, and might even trigger a myocardial infarction or malignant ventricular arrhythmias. We report a case of ventricular fibrillation due to coronary spasm at the site of myocardial bridge. A 56-year-old man who had suffered from bronchial asthma was given remifentanil combined with sevoflurane in general anesthesia for endoscopic sinus surgery. During the surgery, ventricular fibrillation occurred following coronary spasm with bradycardia, hypotension, bronchospasm. we found myocardial bridge that coincided with an area of coronary spasm after coronary angiography. PMID:20498820
Ventriculoperitoneal shunt blockage due to spontaneous knot formation in the peritoneal catheter. Case report.
Eftekhar, Behzad; Hunn, Andrew
The authors report the third case of ventriculoperitoneal shunt blockage due to spontaneous knot formation in the peritoneal catheter that had been placed in a 3.5-year-old boy 8 months earlier. On surgical exploration a double knot was found 10 cm from the distal end of the peritoneal catheter. Although the underlying mechanism remains unknown, the authors used the analogy of related physical studies and true knot formation in the umbilical cord and determined the possible causes as related to the catheter, volume and configuration of the abdomen, and kinetics of the catheter movements. If further study should reveal a significantly higher incidence of this complication, the authors suggest further in vitro studies, designed to investigate the optimal characteristics and safe range of length of peritoneal catheters in different situations. PMID:18352784
Tongue cancer with mental retardation due to microcephaly: a clinical report.
Enomoto, Akifumi; Nakatani, Takanori; Morikage, Eri; Shimoide, Takeshi; Hamada, Suguru
Oral cancer in patients with mental retardation has not been reported in detail, although the literature on clinical management of oral malignancies in the general population is extensive. No clear consensus has been established regarding the management of oral cancer in patients with mental retardation. We present herein the case of a 32-year-old Japanese man with mental retardation due to microcephaly who presented with advanced tongue cancer. He was treated with three courses of chemotherapy using superselective intra-arterial infusion of cisplatin at 100Āmg/m(2) via the femoral artery (Seldinger method). No major complications were encountered, and complete response was achieved. The patient has shown no clinical or radiological evidence of local recurrence or distant metastases as of 22Āmonths after the end of treatment. This case provides a basis for the future appropriate management of oral cancer in patients with mental retardation. PMID:26179630
Locked-in Syndrome due to Central Pontine Myelinolysis: Case Report
Sohn, Min Kyun
Central pontine myelinolysis (CPM) classically occurs in alcoholics, malnourished individuals, chronic liver diseases, and rapid correction of hyponatremia. This report presents locked-in syndrome due to CPM following rapid correction of hyponatremia. A 44-year-old male came to the hospital due to a short period of loss of consciousness. He was alert and had no focal neurological abnormalities at admission. The serum sodium concentration was 118 mEq/L and was corrected to 134 mEq/L in the first 18 hours. One week later, progressive weakness in limbs developed and he progressed to a complete quadriplegic state and bulbar palsy, with only eye blinking preserved. Brain magnetic resonance imaging revealed a characteristic hyperintense signal abnormality in both pons, so he was diagnosed to locked-in syndrome caused by CPM. The patient gradually improved following continuous intensive rehabilitation for more than 2 years. He was able to move all joint muscles against gravity in generally and he could gait under supervision. PMID:25379502
Locked-in Syndrome due to Central Pontine Myelinolysis: Case Report.
Sohn, Min Kyun; Nam, Jin Hee
Central pontine myelinolysis (CPM) classically occurs in alcoholics, malnourished individuals, chronic liver diseases, and rapid correction of hyponatremia. This report presents locked-in syndrome due to CPM following rapid correction of hyponatremia. A 44-year-old male came to the hospital due to a short period of loss of consciousness. He was alert and had no focal neurological abnormalities at admission. The serum sodium concentration was 118 mEq/L and was corrected to 134 mEq/L in the first 18 hours. One week later, progressive weakness in limbs developed and he progressed to a complete quadriplegic state and bulbar palsy, with only eye blinking preserved. Brain magnetic resonance imaging revealed a characteristic hyperintense signal abnormality in both pons, so he was diagnosed to locked-in syndrome caused by CPM. The patient gradually improved following continuous intensive rehabilitation for more than 2 years. He was able to move all joint muscles against gravity in generally and he could gait under supervision. PMID:25379502
Secondary Involvement of the Mandible due to Basal Cell Carcinoma: A Case Report
Mosannen Mozaffary, Pegah; Delavarian, Zahra; Amirchaghmaghi, Maryam; Dalirsani, Zohreh; Vazifeh Mostaan, Leila; Saghafi Khadem, Shadi; Ghalavani, Hanieh
Basal cell carcinoma (BCC) is the most common cutaneous malignancy among Caucasians. Rare examples of aggressive and neglected BCC have been reported. Here we report a unique case of a neglected BCC with significant jaw involvement. A 50-year-old female, referred by an otorhinologist, presented with a large ulcer on her chin, which was extended to her mandibular vestibule. The ulcer was 9ū5.5 cm in size, and tissue destruction, necrosis was observed in the central portion, and the mandibular bone was exposed. On intraoral examination, tooth mobility and severe bone loss were evident. Due to the primary cutaneous origin of the lesion, BCC was considered as preliminary diagnosis. Biopsy was performed and diagnosis of BCC was confirmed. The diseased mandibular bone was resected and reconstructed with a surgical plate. The soft tissue defect was reconstructed with deltopectoral flap. The patient refused secondary stage plastic surgery. Although BCC is not a lethal malignancy, if left untreated and neglected, it can result in severe destruction, disfigurement, and even mortality. PMID:25999630
Knee Locking in Osteoarthritis due to Synovial Lipoma: A Case Report
S. Amarjit, Kataria; Budhiraja, Shivali; Chandramouleeswari, K.; Anita, S.
Intra¢articular synovial lipomas are very rare and only few cases have been reported till now. We are reporting a rare case of a unilateral intra¢articular lipoma of osteoarthritic knee joint in a 62 years old male. Patient had two episodes of sudden locking of knee joint, which resolved spontaneously. A plain X-ray showed changes which were suggestive of osteoarthritis. Clinically, patient was diagnosed as a case of loose bodies in left knee joint. An arthrotomy was performed. After a Histopathological Examination (HPE) of loose bodies, a diagnosis of an intra¢articular synovial lipoma was made. Due to wide differentials and varied clinical behaviour of loose bodies, lipoma should be included in differential diagnosis of osteroarthritic patients who complain of episodic locking of knees. Intraarticular lipomas, on arthroscopic guided excision, get cured permanently, with no recurrence. The differentiation of an intra-articular lipoma from a relatively more common entity, Lipoma arborescens, has also been discussed. PMID:24086885
Chiropractic management of a patient with lumbar spine pain due to synovial cyst: a case report
Cox, James M.
Introduction The purpose of this study is to report the findings resulting from chiropractic care using flexion distraction spinal manipulation for a patient with low back and radicular pain due to spinal stenosis caused by a synovial cyst. Case Report A 75-year-old man presented with low back pain radiating to the right anterior thigh and down the left posterior leg of 3 years' duration. Physical and imaging examinations showed a synovial cyst¢induced spinal stenosis at the right L3-L4 level and bilateral L4-L5 spinal stenosis. Intervention and Outcomes Flexion distraction spinal manipulation and physiological therapeutics were applied at the levels of stenosis. After 4 visits, the patient noted total absence of the right and left lower extremity pain and no adverse reaction to treatment. After 3 months of treatment and 16 visits, his low back and buttock pain were minimal; and he had no leg pain. Conclusion Lumbar synovial cyst and stenosis¢generated low back and radicular pain was 80% relieved in a 75-year-old man following Cox flexion distraction spinal manipulation. PMID:22942836
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Rare and severe complications of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a case report
Introduction We report the case of a patient with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency who presented with unusual anatomical and biochemical features, namely massively enlarged adrenal glands, adrenogenital rest tissue and an unexpected endocrine profile. The contribution of the adrenocortical cells in the adrenals and testicles was determined by a cosyntropin stimulation test before and after adrenalectomy. To the best of our knowledge this is the first report of such a case in the literature. Case presentation A 35-year-old Caucasian man was admitted to the emergency room with an Addisonian crisis. He had been diagnosed with congenital adrenal hyperplasia in the neonatal period. He acknowledged poor adherence to treatment and irregular medical assistance. Physical examination revealed marked cutaneous and gingival hyperpigmentation, hypotension, and hard nodules in the upper pole of both testicles. Blood analysis showed mild anemia and hyponatremia and no evidence of acute infection. Endocrine evaluation showed very low cortisol levels, low dehydroepiandrosterone-sulfate and elevated corticotropin, 11-deoxycortisol and delta-4-androstenedione. The concentration of 17-hydroxyprogesterone was 20,400ng/dL. After the cosyntropin stimulation test the pattern was similar and there was no significant increase in cortisol or 17-hydroxyprogesterone. The abdominal computed tomography scan revealed grossly enlarged and heterogeneous adrenal glands (left, 12cm; and right, six cm). A bilateral adrenalectomy was performed and pathologic examination revealed adrenal myelolipomas with nodular cortical hyperplasia. The sonogram showed bilateral heterogeneous masses on the upper pole of both testes which corresponded to the nodular hyperplasia of adrenal rest tissues. The genetic study revealed compound heterozigoty (mutations R124H and R356W), suggestive of a phenotypically moderate disease. We performed a cosyntropin stimulation test after adrenalectomy. The steroidogenic profile displayed the same unusual features, indicating an important contribution from the adrenogenital cells. Conclusion This case illustrates that congenital adrenal hyperplasia due to 21-hydroxylase deficiency can progress to severe acute and chronic complications. The masses in the patientÆs adrenal glands and testicles resulted from chronically elevated adrenocorticotropic hormone and growth of adrenocortical cells. The basal and stimulated steroid profile, before and after adrenalectomy, revealed an unexpected pattern, suggesting significant contribution of the testicular adrenal cells to the steroidogenesis. PMID:23388220
Omalizumab in pregnant women treated due to severe asthma: two case reports of good outcomes of pregnancies
Tworek, Damian; Kuna, Piotr
The article presents case reports of 2 women who became pregnant during therapy with omalizumab. Both subjects suffered from very severe asthma and were treated chronically with all available medications including systemic steroids (first ¢ 20 mg prednisolone/day, second ¢ 40 mg prednisolone/day). Both were enrolled into treatment with omalizumab and started regular therapy in 2007. The course of asthma significantly improved in both cases (withdrawal of oral steroids or significant reduction of their dose, better asthma control). The first woman, 32-year-old, became pregnant in 2010 and gave birth in Oct 2010 ¢ it was her 3rd pregnancy, and 3rd labor. The second woman, 31-year-old, also became pregnant in 2010 and gave birth in Jan 2011 ¢ it was her 5th pregnancy and 2nd labor. Both had severe asthma exacerbations during previous pregnancies and labors, and decided to continue therapy with omalizumab. The first woman, besides omalizumab, was treated with high doses of inhaled corticosteroids (ICS) and long-acting ? agonists (LABA) while the second one was treated with high doses of ICS, LABA and 2.5 mg to 5 mg prednisone/day. The pregnancies proceeded without asthma exacerbations. The first woman delivered a healthy girl (Apgar 9, weight 3200 g, length 56 cm) in the 40th week of pregnancy by caesarean section due to the narrow pelvis. The second one delivered a healthy boy (Apgar 9, weight 3800 g, length 56 cm) in week 40 by caesarean section due to the aggravating obstetrical history. In both cases, treatment with omalizumab did not affect pregnancies and newborns. PMID:25097476
[Non-fatal hyperkalemia in lactic acidosis due to metformin overdose. Report of one case].
DĒaz, Rienzi; Vega, Jorge; Goecke, Helmuth
We report a 74-year-old man with diabetes mellitus type 2 and hypertension, who recently underwent coronary bypass surgery due to severe triple vessel disease receiving cardiological and combined antidiabetic therapy, including metformin 4 g/day. He was admitted with abdominal pain, nausea, vomiting, diarrhea and loss of consciousness. At admission, he was disoriented and agitated with signs of poor perfusion. His blood pressure was 80/70 mmHg, pulse rate 40 beats/min, respiratory rate 20-breaths/min, and axillary temperature 35░C. Biochemical profile revealed an extreme hyperkalemia of 15.4 mEq/L (double checked), elevated creatinine, uremia and brain natriuretic peptide; hypoglycemia (blood glucose 68 mg/dl) and normal C Reactive Protein. Arterial blood gases revealed severe lactic acidemia. The electrocardiogram showed sinus bradycardia, simple AV block, widened QRS with prominent T wave and prolonged QT. He was admitted to the Intensive Care Unit (ICU) with the suspicion of lactic acidosis associated with metformin, receiving fluid management, intravenous hypertonic glucose plus insulin and sodium bicarbonate, mechanical ventilation, vasopressor therapy, a temporary pacemaker lead, in addition to continuous venovenous hemodiafiltration. Two days later, the patient experienced a significant clinical improvement with normalization of the acid-base status, plasma lactate and potassium levels. On day 9, diuresis was recovered, creatinine and uremia returned to normal levels and the patient was discharged from the ICU. PMID:26005828
Drug-induced liver injury due to varenicline: a case report
Background Liver injury due to prescription and nonprescription medications is an expanding public health concern in the United States, with drug-induced liver injury (DILI) being the single most common reason for regulatory actions instituted by the Food and Drug Administration against certain medications and supplements. Case presentation A 69-year-old Latino man was referred to Hepatology Clinic for urgent evaluation of new onset jaundice, nausea and fatigue associated with a >40-fold increase in his transaminase levels and elevated INR and alkaline phosphatase. The patient had received a new prescription for varenicline to aid with smoking cessation approximately 3 weeks prior to his evaluation in Hepatology Clinic. Within 5?days of starting the varenicline, the patient developed new onset of nausea, vomiting, malaise and deep jaundice. The varenicline was discontinued on day 5 by the patient. Hepatologic evaluation revealed no evidence of acute viral hepatitis, autoimmune, metabolic or alcohol-related liver disorders. The patientÆs past medical history was notable, however, for chronic hepatitis C. His liver enzymes and synthetic function completely normalized 9?weeks after discontinuation of the varenicline. Conclusion This report represents the second documented cases of drug-induced liver injury related to varenicline therapy, highlighting the need for clinician awareness regarding potential hepatotoxicity of varenicline, particularly among patients with pre-existing liver disease. PMID:22681894
Acute Kidney Injury and Quadriparesis Due to Rosuvastatin Induced Rhabdomyolysis- A Case Report
Vanikar, Aruna V.; Trivedi, Hargovind L.
Statins as lipid lowering drugs, are safe and effective in reducing cardiovascular disease risk, but rarely produce myopathy like myalgia, myositis or rhabdomyolysis. We report the case of Rosuvastatin induced rhabdomyolytic acute renal failure and quadriparesis in a 67-year old male, a known case of type-2 diabetes mellitus and with a history of coronary angioplasty four months back. He was on antihypertensive, oral hypoglycemic and antiplatelet medications with Rosuvastatin 40mg/day. He was admitted with altered sensorium, breathlessness, vomiting, muscle weakness and decreased urine output and had raised serum creatinine, creatinine phosphokinase and myoglobin. After ruling out all other causation for rhabdomyolysis, we stopped Rosuvastatin and started supportive management and hemodialysis. Patient showed gradual recovery in renal function and quadriparesis. Patient was discharged with good urine output and on antihypertensive, hypoglycemic drug and diet restrictions for lipid control. He recovered completely and had normal renal function with well controlled lipid level on follow up of 6 months after discharge. Thus, prompt diagnosis of Rhabdomyolysis due to Rosuvastatin in absence of other aetiology and the multidisciplinary management can prevent further complication with favorable outcome. PMID:26155510
Esophageal obstruction due to enteral feed bezoar: A case report and literature review.
Marcus, Esther-Lee; Arnon, Ron; Sheynkman, Arkadiy; Caine, Yehezkel G; Lysy, Joseph
This paper describes a rare complication of enteral feeding, esophageal obstruction due to feeding formula bezoar, and reviews the published cases. An attempt to re-insert the nasogastric tube in a chronically ventilated 80-year-old female fed via a nasogastric tube with Jevity(«) failed. An esophagogastroduodenoscopy revealed an 18 cm-long concretion of the feeding formula, filling most of the esophageal lumen, which was removed endoscopically. Forty-two cases of feeding formula esophageal bezoars have been reported in the literature. The formation of feeding formula bezoars is triggered by acidic gastroesophageal reflux. The acidic pH in the esophagus causes clotting of the casein in the formula. Predisposing factors for bezoar formation are: mechanical ventilation, supine position, neurological diseases, diabetes mellitus, hypothyroidism, obesity and history of partial gastrectomy. Diagnosis and removal of the bezoar is done endoscopically. Feeding in a semi-recumbent position, administration of prokinetic agents and proton pump inhibitors may prevent this complication. PMID:21160586
Small Intestinal Obstruction with Intussusception due to Acute Myeloid Leukemia: A Case Report
Kini, Sangeeta; Amarapurkar, Anjali; Balasubramanian, Meenaskshi
Myeloid sarcoma is known to precede the development of acute myeloid leukemia (AML) and can be the only clinical manifestation. Gastrointestinal involvement by AML is rare with the commonest site being small intestine. Patients present with vague abdominal pain and/or obstruction. Prognosis is usually poor as most of them rapidly progress to AML. We report a case of 25-year-old man with complaints of abdominal pain and vomiting of one-year duration. OGD scopy revealed infiltration of lesser curvature of stomach. Subsequently patient came back within a week with signs and symptoms of acute intestinal obstruction for which an ileal resection was done. Although the histology of stomach biopsy and ileal segments showing similar features were thought to be non-Hodgkin's lymphoma, immunohistochemistry confirmed the diagnosis of myeloid sarcoma. Bone marrow investigations confirmed involvement by AML. Patient succumbed to the disease due to extensive involvement of AML. This case highlights the primary gastrointestinal manifestation of AML which can often prove to be a diagnostic difficulty clinically and histologically. Prompt diagnosis is essential to hasten the management. PMID:22928122
Successful treatment of an abdominal aortic aneurysm by endovascular graft placement through a previously placed prosthetic graft: Report of a case.
Hori, Daijiro; Yuri, Koichi; Nemoto, Kazunari; Yamaguchi, Atsushi; Adachi, Hideo
A 77-year-old man with an infrarenal abdominal aortic aneurysm was referred with a complex medical history including pancreatitis, chronic renal failure, atrial fibrillation, and a cerebral infarction. He also had a history of atherosclerosis obliterans, treated with a vascular bypass using an 8-mm prosthetic graft 9 years previously. His complicated anatomy, including a small access route and a large common iliac artery, suggested usage of Powerlink, a bifurcated stent graft through the previously placed graft, as an access route. The patient was discharged from the hospital with a type III endoleak, which was completely resolved 5 months after discharge. PMID:21110163
Cutaneous metastases secondary to colorectal carcinoma may not be as ominous as previously thought: a case report and review of the literature
Aravind, Biju; Kumar, Rohan; Basnyat, Pradeep
Cutaneous metastasis is considered as an advanced presentation of colorectal cancer and mostly managed with palliative measures. We present a case report where such a case was radically treated with good result and review such reports published in literature. This shows a distinct subgroup that could benefit from such radical approach. PMID:23821624
Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
Edward Shaw; Charles Scott; Luis Souhami; Robert Dinapoli; Robert Kline; Jay Loeffler; Nancy Farnan
Purpose: To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases.Methods and Materials: Adults with cerebral or cerebellar solitary non-brainstem tumors ? 40 mm in maximum diameter were eligible. Initial radiosurgical doses were 18 Gy for tumors ? 20 mm, 15 Gy for those 21¢30 mm, and 12
P.L. 89-313 Supplementary Services for Previously Non-Public-School Institutionalized Students, 1982-1983. O.E.E. Evaluation Report.
ERIC Educational Resources Information Center
New York City Board of Education, Brooklyn, NY. Office of Educational Evaluation.
The Supplementary Services for Previously Non-Public-School Institutionalized Students in New York City was designed to assist students who were formerly educated at state-operated or state-supported schools to adapt to public school education. The 1982-83 program served 1054 students in 367 sites, which included community schools, high schools, aģ
Successful treatment of an abdominal aortic aneurysm by endovascular graft placement through a previously placed prosthetic graft: Report of a case
Daijiro Hori; Koichi Yuri; Kazunari Nemoto; Atsushi Yamaguchi; Hideo Adachi
A 77-year-old man with an infrarenal abdominal aortic aneurysm was referred with a complex medical history including pancreatitis,\\u000a chronic renal failure, atrial fibrillation, and a cerebral infarction. He also had a history of atherosclerosis obliterans,\\u000a treated with a vascular bypass using an 8-mm prosthetic graft 9 years previously. His complicated anatomy, including a small\\u000a access route and a large common
[Unilateral auditory hallucinations due to left temporal lobe ischemia: a case report].
Anegawa, T; Hara, K; Yamamoto, K; Matsuda, M
Unilateral auditory hallucinations are a rare lateralization phenomenon experienced in one ear or from one direction. We recently encountered a 63-year-old right-handed man who developed transient unilateral auditory hallucinations associated with pure word deafness. The patient had a past history of myocardial infarction, lung cancer and aortic aneurysm, but no previous psychiatric or convulsive disorders. About six months before admission, he developed right hemiparesis and motor aphasia caused by a hemorrhagic left parietal infarct. These symptoms gradually improved over three weeks. Two days before admission, he suddenly lost the ability to understand spoken words. He concurrently experienced auditory hallucinations arising from the right anterior direction. On admission, he was very embarrassed to simple verbal commands. He was unable to comprehend spoken words and repeat speech, although he could fairly follow written commands. Confrontation naming, reading aloud, comprehension, spontaneous writing remained relatively unaffected, although he occasionally made paraphasic errors. He could distinguish environmental sounds such as a telephone ringing or running water. After gradual improvement of his auditory incomprehension, he began to describe auditory hallucinations of verbal, musical and elementary types. He was fully aware of the hallucinatory nature of his experience, and took some notes. Two days before admission, from the right anterior side of his head he heard a familiar radio announcer reporting news about the earthquake in Osaka Prefecture and the recommended places of refuge. After similar experiences over several days, he repetitively heard a familiar Japanese traditional song from the right side, which was followed by elementary auditory hallucinations such as a car engine and a siren. These symptoms spontaneously disappeared after nine days. Besides his auditory hallucinations, visual hallucinations and illusional emotion were temporarily present. The Wechsler adult intelligence scale revealed a verbal IQ of 91 and a performance IQ of 100. Pure tone audiometry revealed bilateral, mild peripheral sensorineural hearing loss. Brainstem auditory evoked potentials were unrevealing. The EEG showed slow activities in the left temporoparietal region. Magnetic resonance imaging of the brain failed to reveal any relevant abnormalities except for an old hemorrhagic parietal infarct. The SPECT with Tc99m-HMPAO, however, showed reduced blood flow in the left temporal lobe including the first temporal convolution as well as in the left parietal lobe. Based on the SPECT findings, unilateral auditory hallucinations in our patient are considered to have resulted from the left temporal lobe ischemia. Our case indicates that unilateral auditory hallucinations may have a clinicoanatomical correlation with contralateral temporal lobe lesions. PMID:8821499
Case report: Colonic bezoar due to Box Myrtle seeds: A very rare occurrence
Chauhan, Narvir Singh; Sood, Dinesh
Large bowel seed bezoars are rare and are mostly due to seeds of sunflower, prickly pear cactus, sesame and cucumber. We present a rare case of sigmoid colon seed bezoar due to Box Myrtle seeds because of an underlying benign stricture. PMID:21431028
The Extent to Which Four-Year College Presidents Who Previously Served as Senior Student Affairs Officers Report Having the Characteristics of Effective Presidents
ERIC Educational Resources Information Center
Risacher, Joanne
Results of a research study to determine the extent to which presidents of 4-year institutions with Senior Student Affairs Officer (SSAO) experience share the leadership characteristics of effective presidents as defined by earlier research are reported. Based on analysis of the data using t test and ANOVA statistical procedures, it is concludedģ
Accidental death due to complete autoerotic asphyxia associated with transvestic fetishism and anal self-stimulation - case report.
Atanasijevi?, Tatjana; Jovanovi?, Aleksandar A; Nikoli?, Slobodan; Popovi?, Vesna; Jasovi?-Gasi?, Miroslava
A case is reported of a 36-year-old male, found dead in his locked room, lying on a bed, dressed in his mother's clothes, with a plastic bag over his head, hands tied and with a barrel wooden cork in his rectum. Two pornographic magazines were found on a chair near the bed, so that the deceased could see them well. Asphyxia was controlled with a complex apparatus which consisted of two elastic luggage rack straps, the first surrounding his waist, perineum, and buttocks, and the second the back of his body, and neck. According to the psychological autopsy based on a structured interview (SCID-I, SCID-II) with his father, the deceased was single, unemployed and with a part college education. He had grown up in a poor family with a reserved father and dominant mother, and was indicative of fulfilling DSM-IV diagnostic criteria for alcohol dependence, paraphilia involving hypoxyphilia with transvestic fetishism and anal masturbation and a borderline personality disorder. There was no evidence of previous psychiatric treatment. The Circumstances subscale of Beck's Suicidal Intent Scale (SIS-CS) pointed at the lack of final acts (thoughts or plans) in anticipation of death, and absence of a suicide note or overt communication of suicidal intent before death. Integration of the crime scene data with those of the forensic medicine and psychological autopsy enabled identification of the event as an accidental death, caused by neck strangulation, suffocation by a plastic bag, and vagal stimulation due to a foreign body in the rectum. PMID:19556957
[Case report of live threatening complications due to self insertion of foreign body into the vagina for masturbation purpose].
Kuzaka, Boles?aw; Kobry?, Andrzej; Niemierko, Maciej; Czaplicki, Maciej
Authors have reported a case report of life threatening complications due to insertion of foreign bodies into the vagina, because of masturbation purpose. In this case subsequently came to perforation of the urinary bladder by the huge calculus that developed over the foreign body, and next to the peritoneum with development peritonitis and acute renal insufficiency with the need of dialysotherapy. After a number of surgical operations, the patient with a definitive percutaneous nephrostomy was discharged. PMID:20043585
Native Valve Endocarditis due to Ralstonia pickettii: A Case Report and Literature Review
Orme, Joseph; Rivera-Bonilla, Tomas; Loli, Akil; Blattman, Negin N.
Ralstonia pickettii is a rare pathogen and even more rare in healthy individuals. Here we report a case of R. pickettii bacteremia leading to aortic valve abscess and complete heart block. To our knowledge this is the first case report of Ralstonia species causing infective endocarditis with perivalvular abscess. PMID:25648998
Fungal Osteomyelitis of Calcaneus due to Candida albicans: A Case Report
Lee Fleming; Alan Ng; Matthew Paden; Paul Stone; Dustin Kruse
Osteomyelitis can be a challenging entity to treat. Because of the emergence of risk factors, including broad-spectrum antibiotics, intravenous drug abuse, immunocompromised hosts, and other factors, opportunistic pathogens have increased in prevalence in bone infections. A review of the published data revealed few reported cases of fungal osteomyelitis localized to the foot. In the present report, we describe a rare
Native Valve Endocarditis due to Ralstonia pickettii: A Case Report and Literature Review.
Orme, Joseph; Rivera-Bonilla, Tomas; Loli, Akil; Blattman, Negin N
Ralstonia pickettii is a rare pathogen and even more rare in healthy individuals. Here we report a case of R. pickettii bacteremia leading to aortic valve abscess and complete heart block. To our knowledge this is the first case report of Ralstonia species causing infective endocarditis with perivalvular abscess. PMID:25648998
A case of human enteric myiasis due to larvae of Hermetia illucens (Family: Stratiomyiadae): first report in Malaysia.
Lee, H L; Chandrawathani, P; Wong, W Y; Tharam, S; Lim, W Y
A case of true enteric myiasis in a 7-year-old girl is reported. Two larvae were obtained from the vomitus of the patient. After processing and identification, the larvae were found to be those of Hermetia illucens (Soldier Fly). This is the first case of true enteric myiasis due to these larvae in Malaysia. PMID:8935136
Irreducible dorsal dislocation of the interphalangeal joint of the thumb due to the palmar plate. A case report.
Gerard, F; Pem, R; Garbuio, P; Obert, L; Tropet, Y
Dorsal dislocation of the thumb interphalangeal joint is rare. Only very few cases of irreducible dislocation has been reported at this joint. The authors report a case of compound irreducible dislocation due to the palmar plate interposition. The sesamoid, the flexor pollicis longus have been reported to block reduction of the dorsal dislocation of the thumb interphalangeal joint doctors on casualities should not insist if reduction is not easily obtained, the patient should then be guide towards a surgical team for surgical treatment. PMID:10941386
Fibrosing mediastinitis due to Aspergillus with dominant cardiac involvement: report of two autopsy cases with review of literature.
Chatterjee, Debajyoti; Bal, Amanjit; Singhal, Manphool; Vijayvergiya, Rajesh; Das, Ashim
Fibrosing mediastinitis (FM) is a rare condition characterized by extensive proliferation of fibrous tissue in the mediastinum resulting in mass like lesion. Histoplasma and Mycobacterium tuberculosis are the common infective causes of fibrosing mediastinitis, but Aspergillus infection is an extremely rare cause. Fibrosing mediastinitis due to Aspergillus usually occurs following Aspergillus bronchopneumonia. Cardiac involvement due to Aspergillus-related fibrosing mediastinitis is extremely rare in immune-competent individuals and occurs following some intervention or as a part of disseminated systemic fungal infection. Here, we report two cases of Aspergillus FM with dominant cardiac involvement in immune-competent patients. Both cases presented with large mediastinal mass and large vegetation in the left atrium. Autopsy findings showed the granulomatous Aspergillus mediastinitis and extension into the heart with associated fibrosis. One case was proven to be due to Aspergillus flavus by fungal genomic sequencing. To the best of our knowledge, this is the first report of Aspergillus FM with pancarditis. PMID:24998315
Severe obstruction of the urinary tract due to talcum powder granuloma after surgery. A case report.
Sim?ek, F; T³rkeri, L; Ilker, Y; K³ll³, S; Akda?, A
Talcum powder which is generally used for lubrication of surgical gloves can be responsible for granuloma formation with subsequent complications. This is the report of a case with progressive urinary tract obstruction. PMID:1624242
Traumatic Brain Injury Due to Bull Assault in a Girl: a Case Report
ALVIS-MIRANDA, Hernando Raphael; CASTELLAR-LEONES, Sandra Milena; VEL┴SQUEZ-LOPERENA, Dufays Danith; VILLA-DELGADO, Rosmery; ALCALA-CERRA, Gabriel; MOSCOTE-SALAZAR, Luis Rafael
ABSTRACT Traumatic brain injury is a common condition in the emergency services, affecting the pediatric and adult population significantly. Patterns of head injury as well as management principles in children are important differences compared to adults. Traumatic brain injury by bull rush is usually seen in adults but has not been described in children-report a pediatric cranial trauma present bull rush, which to our knowledge is the first report in the literature of this nature. PMID:24790672
Toxic epidermal necrolysis probably due to cosmetic cream: a case report.
Kokcam, Ibrahim
Toxic epidermal necrolysis (TEN) is a severe and life-threatening cutaneous reaction usually caused by systemic drug administration. Preparations applied to the skin and mucous membranes topically very rarely induce TEN. We present a case of TEN in a 35-year-old woman probably due to facial application of an over-the-counter (OTC) cosmetic cream. PMID:19350188
Irreducible ankle fracture-dislocation due to tibialis anterior subluxation: a case report.
Natoli, Roman M; Summers, Hobie D
Irreducible ankle fracture-dislocations are rare. Several cases of irreducible ankle fracture-dislocation have been reported in published studies secondary to the tibialis posterior tendon, deltoid ligament, or extensor digitorum longus tendon blocking the reduction. We report a case of irreducible ankle fracture-dislocation resulting from posteromedial subluxation of the tibialis anterior tendon around a medial malleolar fracture fragment. Ultimately, the ankle required open reduction of the incarcerated tendon to reduce the joint and proceed with internal fixation of the associated fracture. The patient's postoperative course was uncomplicated, and the tibialis anterior tendon was functioning at 10 months postoperatively, after which he did not return for follow-up examinations. To our knowledge, this is the first reported case of the tibialis anterior tendon blocking closed reduction of an ankle fracture-dislocation. PMID:25618805
Neonatal alloimmune thrombocytopenia due to anti-human leukocyte antigen antibody: a case report.
Sasaki, M; Yagihashi, A; Kobayashi, D; Watanabe, N; Fujikawa, T; Chiba, S; Sato, S; Morishita, K; Sekimoto, T; Ikeda, H
Anti-HLA antibodies reportedly exist in 31% of pregnant women. However, few ocurrences of neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA antibody have been reported. In this study, maternal anti-HLA B60 and B61 antibodies were identified in patient serum at birth, but no anti-platelet antibodies were present. No maternal anti-HLA A2, A24, B51, or B52 antibodies were detected in patient serum. Platelet transfusion from the third donor was effective because these platelets expressed HLA A24 and B52 but not B60 or B61. Cross-matching tests between patient leukocytes or platelets and maternal serum were strongly positive, indicating that maternal anti-HLA antibodies were responsible for NAIT. This report is the first to demonstrate NAIT probably caused by maternal anti-HLA A24 and B52. PMID:11764101
Persistent ascites due to sclerosing encapsulating peritonitis mimicking ovarian carcinoma: A case report
Ūa?lar, Mete; Ūetinkaya, Nil³fer; ųzg³, Emre; G³ng÷r, Tayfun
Sclerosing encapsulating peritonitis, also known as æCocoon SyndromeÆ, is a rare cause of bowel obstruction. The condition might be congenital or acquired and has non-specific symptomatology. Abdominal pain occurs due to the limitation of intestinal motility or segment obstruction by a thick homogenous fibrotic mantle covering the intra-peritoneal organs. Altered peritoneal fluid dynamics result in persistent ascites. Leading pathogenic theories are not well defined, but genetic factors, retrograde trans-tubal flow of causative agents, peritoneal infections, medications and peritoneal invasive procedures are all thought to play a role. There are no specific diagnostic criteria and exact diagnosis is only confirmed during surgery when the investing thick fibrous folds covering the bowel loops are visualised. We present here a case that had been suspected to have an ovarian malignancy due to a huge abdominal heterogeneous mass and ascites on preoperative diagnostic workup, but had a final diagnosis of abdominal Cocoon Syndrome made during surgery. PMID:25317050
[Infections due to Kocuria kristinae: case reports of two patients and review of the literature].
Chßvez Valencia, Venice; Orizaga de la Cruz, Citlalli; Aguilar Bixano, Omar; Huerta RuĒz, Marilyn Karla; Sßnchez Estrada, Erik Emilio
Kocuria kristinae is a gram-positive coccus of the family of Micrococcaceae. It inhabits the skin and mucous and human oropharynx and some mammals. Clinical cases of proven infections are scarce, affecting patients with indwelling devices and severe underlying diseases. We report two unusual case of a K. kristinae infection in a hemodialysis. First is a case of bacteremia associated with permanent hemodialysis catheter in a 20-year-old female; and second is a case of acute peritonitis in a 68-year-old male patient on continuous ambulatory peritoneal dialysis. A review of other reported K. kristinae infections is provided. PMID:25643779
Massive Hemoptysis due to Endotracheal Hemangioma: A Case Report and Literature Review
Yu, Yeonsil; Lee, Suhyeon; An, Jinyoung; Lee, Jeongmin; Kim, Jihoon; Lee, Youngkyung; Jung, Eunah; Song, Sookhee; Kim, Hyeok
Tracheal hemangioma is a rare benign vascular tumor in adults. We reported a case of massive hemoptysis caused by a cavernous hemangioma in a 75-year-old man. This is the first report, to our knowledge, of a tracheal cavernous hemangioma that presented with massive hemoptysis. The lesion was removed with a CO2 laser under rigid laryngoscopy. Endovascular tumors, such as tracheobronchial hemangiomas, should be considered a diagnostic option in cases of massive hemoptysis without a significant underlying lung lesion. PMID:25861344
Localized hypertrichosis due to temporary henna tattoos: report of three cases.
Durmazlar, Selda Pelin Kartal; Tatlican, Semih; Eskioglu, Fatma
Temporary henna tattoos have become increasingly widespread. Although reactions to henna tattoo are becoming progressively more common, only one case of a henna pseudotattoo resulting in temporary hypertrichosis has been reported so far. We report three patients who received paint-on henna tattoos on their right upper arm. Approximately 1 week later, localized hypertrichosis was observed over the same area as the tattoo, which resolved spontaneously within 3-4 months. Clinicians should be aware of this complication and it should be noted that treatment is not necessary as hypertrichosis resolves spontaneously. PMID:19954396
Fatal myeloencephalopathy due to accidental intrathecal vincristin administration: a report of two cases.
Dettmeyer, R; Driever, F; Becker, A; Wiestler, O D; Madea, B
We report on two fatal cases of accidental intrathecal vincristine instillation in a 5-year old girl with recurrent acute lymphoblastic leucemia and a 57-year old man with lymphoblastic lymphoma. The girl died seven days, the man four weeks after intrathecal injection of vincristine. Clinically, the onset was characterized by the signs of opistothonus, sensory and motor dysfunction and ascending paralysis. Histological and immunohistochemical investigations (HE-LFB, CD-68, Neurofilament) revealed degeneration of myelin and axons as well as pseudocystic transformation in areas exposed to vincristine, accompanied by secondary changes with numerous prominent macrophages. The clinical course and histopathological results of the two cases are presented. A review of all reported cases in the literature is given. A better controlled regimen for administering vincristine and intrathecal chemotherapy is recommended. PMID:11587867
First report of major vascular injury due to lateral transpsoas approach leading to fatality.
Assina, Rachid; Majmundar, Neil J; Herschman, Yehuda; Heary, Robert F
Extreme lateral interbody fusion (XLIF) has gained popularity among spine surgeons for treating multiple conditions of the lumbar spine. In contrast to the anterior lumbar interbody fusion (ALIF) approach, the minimally invasive XLIF approach affords wide access to the lumbar disc space without an access surgeon and causes minimal tissue disruption. The XLIF approach offers many advantages over other lumbar spine approaches, with a reportedly low complication profile. The authors describe the first fatality reported in the literature following an XLIF approach. They describe the case of a 50-year-old woman who suffered a fatal intraoperative injury to the great vessels during a lateral transpsoas approach to the L4-5 disc space. PMID:25192374
Blood loss anemia due to adenocarcinoma of the jejunum: case report and review of the literature
JoŃo Figueira-Coelho; Sofia Lourenńo; Michele Costa; Paula Mendonńa; Ant¾nio Murinello; Jorge Neta
BACKGROUND: Small bowel tumors are rare, accounting for only 3-6% of gastrointestinal neoplasms, 1-2% of these being malignant. They must be considered whenever a patient presents with gastrointestinal bleeding, with normal upper gastrointestinal endoscopy and colonoscopy. CASE PRESENTATION: We report a case of jejunal adenocarcinoma presenting as a blood loss anemia in a 65 year-old male, doing a brief review
Diagnostic assessment and therapeutic approach for immunodeficiency due to chylous dysplasia: A case report.
Boccardo, Francesco; Bellini, Carlo; Girino, Margherita; Campisi, Corrado; Vidali, Francesca; Corazza, Gino Roberto; Campisi, Corradino
Among possible causes of a condition of immunodeficiency, we have to consider the presence of a serious chylous dysplasia, due to the great loss of proteins through the intestinal lumen. A 20-year-old male, suffered from diarrhoea (2-4 times a day), weight loss (8 kilos in 5 years), and malnutrition (hypogammaglobulinemia, hypoalbuminemia, leukocytopenia with lymphocytopenia). Accurate diagnostic assessment allowed to diagnose a protein-losing enteropathy. Conventional oil contrast lymphangiography allowed to accurately assess the case and to establish a proper therapeutic approach. The operation consisted in multiple antigravitational ligatures of dilated and incompetent chylous vessels and chylous vessel-mesenteric vein microanastomoses. Parameters concerning albumin and leukocytes normalized in 1 week after operation and remained stable with time; there were no more episodes of diarrhoea and the patient recovered weight. An accurate diagnostic assessment and above all lymphangiography allow to diagnose properly difficult cases of immunodeficiency due to intestinal protido-dispersion and to plan a correct therapeutic functional approach. PMID:20049915
Jod-Basedow effect due to prolonged use of lugol solution-case report.
Leu?tean, Leti?ia; Preda, Cristina; Ungureanu, Maria-Christina; D?nil?, R; Mogo?, Voichi?a; Stef?nescu, Cipriana; Vulpoi, Carmen
Graves' disease is the most common form of hyperthyroidism, accounting for 60-80% of all cases of thyrotoxicosis. If left untreated, it may lead to severe thyrotoxicosis with cardiovascular, ocular, psychiatric complication, and in extreme cases thyrotoxic crisis with a high mortality rate. We present the case of a 50-years-old woman diagnosed in another service with Graves' disease and treated for many years with antithyroid drugs (ATDs), admitted to our service for a relapse due to treatment discontinuation. The surgical treatment was planned and the preoperative preparation with Lugol solution was initiated. Due to a misunderstanding, the administration of iodine solution was extended for a period of about 30 days, thus generating the so-called Jod-Basedow effect, with the exacerbation of the manifestations of thyrotoxicosis and risk of thyroid storm. The patient received treatment with high ATDs doses, glucocorticoids, and beta-blockers, resulting in the progressive improvement of symptoms. She was discharged from hospital and given the risk of thyrotoxic crisis the surgery was postponed. After a month, the patient underwent thyroidectomy without preoperative preparation with iodine solution. The operative and postoperative courses were uneventful. PMID:25581962
Celiac trunk and branches dissection due to energy drink consumption and heavy resistance exercise: case report and review of literature.
Gonzßlez, Wilma; Altieri, Pablo I; Alvarado, Enrique; Banchs, Hķctor L; Col¾n, Edgar; Escobales, Nelson; Crespo, MarĒa
Higher doses and consumption of energy drinks leads to cardiovascular effects and potential consequences. Principal components found in energy drinks such as caffeine, guarana and taurine has been related to dilatation, aneurysm formation, dissection and ruptures. There is no evidence showing an integration of these components and its effects in endothelium and aortic walls due to higher levels of pressure during exercises. We report a case of a 44 years male with celiac trunk and branches dissection due to long-term consumption of energy drinks and intense exercise routine. Our proposition relates cell and vessel walls alterations including elasticity in endothelial wall due to higher blood pressure, resistance by intense exercise routine and long-term consumption of energy drinks. PMID:26035983
Life-threatening hyponatremia due to intravenous n-acetylcysteine treatment in an infant: a case report
Juan Mayordomo-Colunga; Elene Larrea; M¾nica GarcĒa; Sonsoles Sußrez; Julißn RodrĒguez
INTRODUCTION: N-acetylcysteine has proven to be effective in paracetamol intoxications, but there is no consensus regarding its way of administration. Here, we report a case to highlight the importance of careful management of intravenous n-acetylcysteine. CASE PRESENTATION: A two-month old infant was seen in our paediatric emergency department due to paracetamol poisoning after repeated supratherapeutic doses. She was treated with
Congenital microtia in a neonate due to maternal isotretinoin exposure 1 month before pregnancy: Case Report.
Shirazi, Mahboobeh; Abbariki, Ezzat; Pirjani, Reihaneh; Akhavan, Setareh; Dastgerdy, Ebrahim
Isotretinoin is a drug used for treating severe cystic/nodular acne. Severe malformations have been documented in neonates whose mothers had taken isotretinoin during pregnancy. Women who became pregnant one cycle after completing therapy are believed to be at teratogenic risk not higher than baseline. We describe the case of a newborn whose mother had taken the drug for 4 weeks. The woman then had contraception for 4 weeks (after the drug treatment had finished), and became pregnant after that period. The newborn had isolated bilateral microtia due to suspected isotretinoin exposure. His mother also had a history of urine tract infection in the second week of pregnancy that was treated with cephalexin. The parents were not from a consanguineous marriage and had no family history of congenital malformations. To reduce the risk, effective contraception should be continued in fertile women more than 1 month after completing therapy. PMID:25773513
False positive Lyme serology due to syphilis: report of 6 cases and review of the literature.
Naesens, R; Vermeiren, S; Van Schaeren, J; Jeurissen, A
A 44-year-old man presented with visual field defects. Ophthalmoscopy revealed papilloedema of the left eye. Neuroborreliosis was suspected and serum was positively being tested using VIDAS* Lyme screen II (bioMerieux Vitek Inc). However, confirmatory testing using the Borrelia VlsE C6 titre was negative. Western Blotting on serum and cerebrospinal fluid could not confirm the possible diagnosis of neuroborreliosis. VDRL and TPPA testing was positive, and finally, the diagnosis of neurosyphilis was established. We subsequently screened our database on patients with positive VIDAS Lyme screening and negative confirmatory testing by Western blot, and found another 5 cases in which Lyme screening was false positive due to cross-reactivity with Treponema pallidum antibodies. Our data show that in patients with positive Lyme screening and negative confirmatory testing, performance of lues serology should be considered. PMID:21485767
Occupational death due to bilateral carotid artery occlusion - A medico-legal case report.
Das, Siddhartha; Patra, Ambika Prasad; Shaha, Kusa Kumar; Sukumar, Sanjay; Chaudhari, Vinod Ashok; Rahman, Nisreen Abdul
Occupational deaths are work-related deaths and usually occur in the work place of an individual. A case of occupational death in a female factory worker has been described, where the saree she was wearing accidentally got entangled in the moving belt and caused ligature strangulation. She was unconscious throughout indicating bilateral occlusion of the carotids and died a day after the incident. The authors have described the correlation between the distribution of the injuries on the body and the manner a saree is worn. Investigation of the workplace revealed that the place where she was standing was located between two machines, and the space was inadequate for normal movement. Some suggestions have been offered which may decrease the incidences of occupational ligature strangulation due to entanglement of dress materials in the moving machineries. PMID:25882146
Ileum perforation due to delayed operation in obturator hernia: A case report and review of literatures
Zhang, Hong; Cong, Jin-Chun; Chen, Chun-Sheng
A 83-year-old woman was admitted to our hospital because of intermittent abdominal colicky pain and vomiting for 26 h. The pain localized over the periumbilical area with radiation along the medial side of the thigh. Computed tomography scan with three-dimensional reconstruction revealed a loop of small bowel protruding into the left obturator canal. Incarcerated obturator hernia was diagnosed and emergency laparotomy was arranged immediately. Unfortunately, her family refused surgery because of her worsening condition. On the third evening after admission, the patient developed peritonitis and sepsis. Perforation of small bowel due to the incarceration was noted during laparotomy. Bowel resection and an end-ileostomy were performed. She recovered well despite of the complication of multiple organ dysfunction syndrome. Literature is reviewed, and the pathogenesis, clinical manifestation, imaging features and treatment are discussed. PMID:20039460
Enteric fever due to Salmonella Paratyphi A in Greece: a case report
Chalkias, Athanasios; Anastasopoulos, Dimitrios; Tsiaglis, Stavros
Background Enteric fever is a major global public health problem and growing international travel leads to an increase in the risk of contracting infectious diseases that are endemic in the country of destination. Case presentation A 30-year-old Pakistani male was admitted feeling generally unwell with fever, vertigo, vomiting and headache. Admission blood cultures grew Salmonella ser. Paratyphi A. The patient was successfully treated with intravenous Amoxicillin/Clavulanic Acid and Ciprofloxacin. Conclusion This case report emphasizes the potent spread of Salmonellae bacilli in a developed country. PMID:19087343
Colonic necrosis and perforation due to calcium polystyrene sulfonate in a uraemic patient: a case report.
Akagun, Tulin; Yazici, Halil; Gulluoglu, Mine G; Yegen, Gulcin; Turkmen, Aydin
Sodium or calcium polystyrene sulfonate (Kayexalate or analog) is an ion-exchange resin commonly used to treat hyperkalaemia in patients with chronic kidney disease. It is known to cause digestive complications, such as nausea, vomiting and constipation. Although rare, colonic necrosis and perforation are very severe complications associated with the medication. In this case report, we present a case of calcium polystyrene sulfonate-induced colonic necrosis and perforation to remind clinicians of this rare, but dangerous, toxicity associated with this commonly used medication. PMID:25984206
Spontaneous acute subdural hematoma due to fondaparinux: Report of two cases
Fryburg, Karsten; Nguyen, Ha Son; Cohen-Gadol, Aaron A.
Background: Spontaneous acute subdural hematomas (SDHs) are rare. Risk factors for development of these hematomas include conditions such as hypertension, vascular abnormalities such as aneurysm or arteriovenous malformation, or consumption of anticoagulants. Case Description: Here, the authors report two patients who suffered from spontaneous acute SDH while taking fondaparinux for venous thromboembolism prophylaxis. One patient suffered from a remote episode of traumatic brain injury and underwent a decompressive craniectomy 3 weeks prior to presentation, whereas the other patient had been self-medicating with aspirin. Conclusion: To our knowledge, these two patients illustrate the first cases of spontaneous acute SDH formation most likely attributed to consumption of fondaparinux. PMID:21660271
[Polyneuropathy due to glue-sniffing intoxication. Report of a case].
Fredj, M; Hammami, N; Gouider, R; Ameur Lazzem, R; Mrabet, A
We report a case of a 24 years old female who presented a glue sniffing neuropathy. Symptoms began with progressive weakness which initially involves the lower extremities. Neurological examination noted a decreased Achille reflexes. Nerve conduction studies showed a slowing nerve conduction velocities, a delayed F waves and distal latencies and diffuse nerve conduction blocks. The disease continued to worsen beyond two weeks after stopping intoxication with persistent evidence of ongoing demyelination. 40 days later we have noted an improvement in nerve conduction velocities and in conduction blocks, neuropathy is the most frequent glue sniffing complications, there is a clinic and electric improvement of the polyneuropathy after stopping intoxication. PMID:10730150
Anaerobic Spondylodiscitis due to Fusobacterium Species: A Case Report Review of the Literature
Latta, Tiffany N.; Mandapat, Aimee L.; Myers, Joseph P.
Spondylodiscitis caused by Fusobacterium species is rare. Most cases of spontaneous spondylodiscitis are caused by Staphylococcus aureus and most postoperative cases are caused by Staphylococcus aureus or coagulase-negative staphylococci. Escherichia coli is the most common Gram-negative organism causing spondylodiscitis. Fusobacterium species are unusual causes for anaerobic spondylodiscitis. We report the case of a patient with spontaneous L2-L3 spondylodiscitis, vertebral osteomyelitis, and epidural abscess caused by Fusobacterium species and review the literature for patients with Fusobacterium spondylodiscitis. PMID:26000181
Enterocolic fistula due to a rectal stent: Case report and literature review
Ross, John P.; Orkin, Bruce A.
Introduction Self-expanding metal stents (SEMS) are successfully being used to acutely relieve obstructing colorectal cancers; yet, their use does not come without complications. Presentation of case We present a case in which a patient with a recurrent obstructing sigmoid carcinoma underwent colonic stenting for acute decompression. Two months after stent placement, an enterocolic fistula formed from erosion of the upper end of the stent. Discussion An extensive literature review revealed that fistula formation, as a complication of stent placement, is rarely reported. Presentation of the case is followed by a review of complications that may arise following SEMS placement, with a focus on enterocolic fistulae. To our knowledge, this work provides the most extensive review of the subject to date. Conclusion SEMS provide an effective, safe, and less invasive option for patients when used in the appropriate clinical context. Further reports of enterocolic fistulae as a complication of SEMS placement are necessary in order to better understand this potential adverse event. PMID:25568798
Bilateral testicular self-castration due to cannabis abuse: a case report
Introduction The self-mutilating patient is an unusual psychiatric presentation in the emergency room. Nonetheless, serious underlying psychiatric pathology and drug abuse are important background risk factors. A careful stepwise approach in the emergency room is essential, although the prognosis, follow-up, and eventual rehabilitation can be problematic. We present a unique and original case of bilateral self-castration caused by cannabis abuse. Case Presentation We report a case of a 40-year-old Berber man, who was presented to our emergency room with externalization of both testes using his long fingernails, associated with hemodynamic shock. After stabilization of his state, our patient was admitted to the operating room where hemostasis was achieved. Conclusion The clinical characteristics of self-mutilation are manifold and there is a lack of agreement about its etiology. The complex behavior associated with drug abuse may be one cause of self-mutilation. Dysfunction of the inhibitory brain circuitry caused by substance abuse could explain why this cannabis-addicted patient lost control and self-mutilated. To the best of our knowledge, this is the first case report which presents an association between self-castration and cannabis abuse. PMID:21861879
Drug-induced liver injury due to "natural products" used for weight loss: a case report.
Tarantino, Giovanni; Pezzullo, Martina Gilda; di Minno, Matteo Nicola Dario; Milone, Francesco; Pezzullo, Luigi Sossio; Milone, Marco; Capone, Domenico
Taking herbal-extracts to lose weight is an underestimated health hazard. Often, these products contain active agents that can cause acute liver damage. In this case report, a 22-year-old female patient, who presented with a feature of cholestatic syndrome, was so sure that the "natural products" were not dangerous that she did not inform her physicians that she had taken them, making their task that much more challenging. Clinical presentation mimicked acute cholecystitis and the patient underwent a cholecystectomy. Surgery was without any consequences and complications, although it did not completely cure the illness. She later admitted to having taken herbal remedies and this led to the correct diagnosis of phytotherapy-related hepatotoxicity and a successful therapeutic approach. The true incidence of phytotherapy-related hepatotoxicity and its pathogenic mechanisms are largely unknown. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies. PMID:19452589
Rapidly progressive paraplegia due to an extradural lumbar meningocele mimicking a cyst. Case report.
Fiss, Ingo; Danne, Marco; Hartmann, Christian; Brock, Mario; Stendel, Ruediger
Unlike arachnoid meningoceles, arachnoid cysts frequently cause local pressure effects probably because there is no free communication between the cyst and the subarachnoid space. Following the first detailed description of cystic lesions of spinal nerve roots by Tarlov in 1938, a simplified classification of spinal meningeal cysts was developed in 1988, containing three major categories. The authors report on a lumbar intraspinal extradural meningocele that caused incomplete paraplegia in an otherwise healthy 31-year-old man in whom magnetic resonance imaging revealed stigmata of Scheuermann disease. Intraoperatively, the lesion was classified as a transitional-type lesion, in accordance with Type IA of the Nabors classification, because a communication with the subarachnoid space was observed. After complete removal of the meningocele, the patient's recovery was prompt and complete. PMID:17633492
Intestinal obstruction due to a left paraduodenal hernia: a case report
Introduction A left paraduodenal hernia is a rare congenital malrotational anomaly of the midgut that occurs in the paraduodenal fossa of Landzert to the left of the fourth duodenum. It is responsible for approximately 1% of small bowel obstructions. Case presentation We report a case of left paraduodenal hernia combined with small bowel obstruction in a 47-year-old Mediterranean woman who had a history of recurrent abdominal pain. An abdominal computed tomography scan showed a saclike mass clustered in the left upper quadrant but failed to yield a clear diagnosis. We describe the surgical anatomy of this disease and the emergency surgical management together with a short review of the literature. Conclusions Even though a left paraduodenal hernia is rare, it must be suspected in any upper intestinal occlusion. The high morbidity and mortality rate of complicated cases should motivate preventive treatment in case of incidental operative discovery. PMID:24330743
[Necrotizing pneumonia due to Rhodococcus equi in non HIV immunocompromised host. Case report and review].
Rabagliati, Ricardo; Morales, Arturo; Baudrand, Renķ; Jorquera, Jorge; Odd¾, David; GarcĒa, Patricia; Carmona, M Cecilia; Cisternas, Marcela; Huete, Alvaro
Rhodococcus equi, is a grampositive intracellular bacillus, that causes infection mainly in immunocompromised hosts. We report the case of a 52 years old woman, with a systemic lupus erythematosus and a progressive 10 months evolution with cough, dyspnea, mucous-purulent sputum, occasionally hemoptysis, intermittent fever, and weight loss of 10%. With partial response to antibiotic treatment, radiological evolution of thoracic scanners evidenced the development of multiple bilateral areas of consolidation, some of them nodular. Percutaneous thoracic biopsy showed characteristic histology and microbiological analysis yielded the identification of Rhodococcus equi in both bronchoalveolar lavage and pulmonary biopsy. She received prolonged bi-associated antibiotic treatment with good clinical and radiological response. This agent must be considered in the study of immunocompromised patients that present with a prolonged evolution of pneumonia. PMID:15891796
Schistosomal myeloradiculopathy due to Schistosoma mansoni: Report on 17 cases from an endemic area
Badr, Hatem I.; Shaker, Ashraf A.; Mansour, Mohamed A.; Kasem, Mohamed A; Zaher, Ahmad A.; Salama, Hassan H.; Safwat, Mohamed I.
Background: After malaria, schistosomiasis is the second most prevalent tropical disease. The prevalence of oviposition in CNS of infected persons varies from 0.3 to 30%. The conus medullaris is a primary site of schistosomiasis, either granulomatous or acute necrotizing myelitis. Objective: To report the clinical, radiological, and laboratory results of spinal cord schistosomiasis (SCS) and to design proper therapeutic regimens. Materials and Methods: Seventeen patients (13 males and four females) with SCS were enrolled between 1994 and 2009 at Mansoura University Hospitals. Their median age at diagnosis was 19 years (13-30 years). Independent neurological, radiological, and laboratory assessments were performed for both groups, excluding pathological confirmation that was done earlier in eight patients (Group 1). In the group 2 (nine patients), indirect hemagglutination (IHA) test for bilharziasis in blood and cerebrospinal fluid (CSF) was performed. Higher positive titer in CSF than serum indicated SCS plus induction of antibilharzial and corticosteroid protocols for 12 months with a three-year follow-up. Results: Rate of neurological symptoms of granulomatous intramedullary cord lesion was assessed independently in 16 cases and acute paraparesis in one case. All patients in group 2 had positive IHA against Schistosoma mansoni with median CSF and serum ranges 1/640 and 1/320, respectively. Seven patients (41.18%) had complete recovery, eight patients (47.06%) showed partial recovery, and no response was reported in two patients (11.76%) (P = 0.005). There was no recorded mortality in the current registry. Conclusions: Rapid diagnosis of SCS with early medical therapies for 12 months is a crucial tool to complete recovery. PMID:21808472
Intestinal Obstruction Due to Idiopathic Sclerosing Encapsulating Peritonitis: A Case Report
Yavuz, Ridvan; Akbulut, Sami; Babur, Mehmet; Demircan, Firat
Introduction: Sclerosing encapsulating peritonitis (SEP) is characterized by partial or complete encasement of small intestine by a thick fibrocollagenous membrane. Depending on underlying causes, SEP is divided into primary and secondary forms. Idiopathic SEP is also called idiopathic or abdominal cocoon syndrome. Herein we presented a case of idiopathic SEP. Case Presentation: A 90-year-old male patient presented to our emergency department with signs and symptoms of intestinal obstruction and dehydration. Physical examination findings, patient's age and plain abdominal radiography were consistent with tumoral obstruction or viscus perforation. Explorative laparotomy revealed a fibrous capsule encasing intestines as well as dense adhesions between intestinal loops. Since the overall condition of the patient was not well enough to allow a wide dissection and membrane excision, the operation was terminated after performing a limited loop ileostomy. Unfortunately, the patient was lost due to organ failure at the postoperative period. Conclusions: Despite advances in radiological techniques, the exact diagnosis in many cases is still made according to intraoperative findings and histopathological properties of the excised membrane. While some cases of SEP remain asymptomatic for years, most cases are characterized by recurrent bouts of acute, subacute or chronic intestinal obstruction. To our knowledge, the case presented here is the oldest patient with idiopathic SEP in the literature.
Delayed-onset of multiple cutaneous infantile hemangiomas due to propranolol: a case report.
Porcel Chac¾n, RocĒo; del Boz Gonzßlez, Javier; Navarro Mor¾n, Juan
Infantile hemangiomas are the most common vascular tumors in childhood. In view of its proven effectiveness in such cases, propranolol is the drug of choice. We present the case of a male infant who started treatment with propranolol shortly after birth due to heart disease. After 7 months, when the patient had suffered various respiratory exacerbations, this treatment was suspended. One week later, multiple skin lesions (ie, multifocal infantile hemangiomas) began to appear, with no extracutaneous involvement. It was decided to resume treatment with propranolol, although at lower doses than before, and the skin lesions improved rapidly, with some disappearing completely. Treatment was definitively withdrawn at age 16 months, with only slight recurrence of the lesions. The case described is of multifocal infantile hemangiomas without extracutaneous involvement appearing beyond the neonatal period after treatment with propranolol beginning in the first days of life. The details of the case support the hypothesis that this drug is not only therapeutic but also plays a prophylactic role against infantile hemangiomas. In turn, this supports the recent proposal that this drug may be useful in preventing the growth and spread of tumors with high angiogenic potential. It is postulated that the inhibition of ?-adrenergic receptors is associated with multiple intracellular processes related to the progression and metastasis of different tumors. PMID:25780066
Idiopathic systemic granulomatous pathology causing sudden death due to myocarditis: a rare case report.
Singh, Harpal; Kundal, Ramesh
Idiopathic granulomatous myocarditis is extremely rare, particularly since the introduction of drugs effective against tuberculosis (TB), viruses, fungi and the effective treatment of sarcoidosis. Here is a case of a 65-year-old female prisoner having history of sudden collapse and ultimately death. Autopsy findings of various viscera on histopathological examination show granulomatous pathology, that is, in spleen, liver and in the left ventricular wall of heart. Ziehl-Neelsen staining of the sections show the absence of acid fast bacilli, negative for fungal staining as most of the granulomas are noncaseating type with presence of giant cells having no asteroid body and Schuamann body, real-time polymerase chain reaction for TB is negative. Idiopathic giant cell myocarditis is a disease of relatively young adults, that is, between 3 rd and 4 th decade of life. So, this case is strongly considered to be a case of sudden death due to myocarditis as a result of idiopathic systemic granulomatous pathology, a rare case in in literature. PMID:25673606
[Cerebellar abscess due to infection with the anaerobic bacteria fusobacterium nucleatum: a case report].
Shimogawa, Takafumi; Sayama, Tetsuro; Haga, Sei; Akiyama, Tomoaki; Morioka, Takato
We report a rare case of cerebellar abscess produced by anaerobic bacteria. A 76-year-old man was admitted to our hospital with a history of fever, vomiting, and dizziness lasting 14 days. Computed tomography(CT)scan and magnetic resonance images showed the presence of a multiloculated cerebellar abscess with a right subdural abscess. The patient underwent aspiration of the abscess through a suboccipital craniotomy. Fusobacterium nucleatum, which is an anaerobic bacteria naturally present in the human oral cavity, was detected in cultures of the aspirated abscess. The patient was administered antibiotic treatment combined with hyperbaric oxygen therapy(HBO). The symptoms were briefly relieved but the cerebellar abscess recurred, which required a second aspiration. The combined treatment with antibiotics and HBO was maintained after the second operation. After 6 weeks of treatment, the cerebellar abscess was completely controlled. We conclude that antibiotic treatment combined with HBO is useful for treatment of cerebellar abscesses caused by infection with anaerobic bacteria. PMID:25672555
Onset of complications following cervical manipulation due to malpractice in osteopathic treatment: a case report.
Cicconi, Michela; Mangiulli, Tatiana; Bolino, Giorgio
The aim of this study is to correlate cervical disc herniation with manipulation performed by a non-physician osteopath on a patient complaining of neck pain. The authors report a case in which a woman - treated with osteopathic spinal manipulation - developed cervical-brachial neuralgia following the cervical disc herniation. The patient then underwent surgery and was followed by physiotherapists. A clinical condition characterized by limitation of neck mobility, with pain and sensory deficit in the right arm and II-III fingers, still persists. The patient consulted the authors to establish whether cervical disc herniation could be attributed to manipulation. Adverse events or side effects of spinal manipulative therapy are relatively common and usually benign. Most of these side effects are mild or moderate, but sometimes they can be severe. Cervical manipulation can provoke complications less often than thoracic or lumbar manipulation. Furthermore, many diseases can be absolutely and relatively contraindicated to osteopathic treatment. Therefore, the knowledge of a patient's clinical conditions is essential before starting a manipulative treatment; otherwise the osteopath could be accused of malpractice. It is the authors' opinion that a cause-effect relationship exists between the manipulative treatment and the development of disc herniation. PMID:24402084
Exogenous Cushing's syndrome due to topical corticosteroid application: case report and review literature.
Tempark, Therdpong; Phatarakijnirund, Voraluk; Chatproedprai, Susheera; Watcharasindhu, Suttipong; Supornsilchai, Vichit; Wananukul, Siriwan
Prolonged use of topical corticosteroids causes systemic adverse effects including Cushing's syndrome and hypothalamic-pituitary-adrenal (HPA) axis suppression, which is less common than that of the oral or parenteral route. At least 43 cases with iatrogenic Cushing syndrome from very potent topical steroid usage (Clobetasol) in children and adult have been published over the last 35 years particularly in developing countries. In children group (n = 22), most are infants with diaper dermatitis and two cases who had started topical application at a very early age and died from severe disseminated CMV infection. For the adult group (n = 21), the most common purpose of steroid use was for treatment of Psoriasis. The recovery period of HPA axis suppression was 3.49 ▒ 2.92 and 3.84 ▒ 2.51 months in children and adult, respectively. We report on an 8-month-old female infant who developed Cushing's syndrome and adrenal insufficiency after diaper dermatitis treatment through the misuse of Clobetasol without doctor's prescription. Physiologic dose of hydrocortisone was prescribed to prevent an adrenal crisis for 3 months and discontinued when HPA axis recovery was confirmed by normal morning cortisol and ACTH levels. PMID:20972726
Small bowel angioedema due to acquired C1 inhibitor deficiency: a case report and overview.
Oostergo, Tanja; Prins, Gerrie; Schrama, Yvonne C; Leeuwenburgh, Ivonne
Acquired angioedema is a rare disorder caused by an acquired deficiency of C1 inhibitor. It is characterized by nonpitting, nonpruritic subcutaneous or submucosal edema of the skin, or of the respiratory or gastrointestinal tract. When localized in the gastrointestinal tract, it can cause severe abdominal pain, mimicking an acute surgical abdomen, or chronic recurrent pain of moderate intensity. We report a case of a 48-year-old man presenting with recurrent episodes of hypotension and abdominal pain. Computed tomography of the abdomen showed edema of the small bowel. The first determinations of C1 inhibitor level and activity, measured in a symptom-free period, were normal. Repetition of the laboratory tests in the acute phase, however, showed a low C1 inhibitor level. Further diagnostic work-up indicated an acquired C1 inhibitor deficiency caused by a monoclonal gammopathy. He was treated with tranexamic acid as prophylaxis for his frequent attacks and to date, he has remained symptom free. Acquired C1 inhibitor deficiency is a rare cause of angioedema and is, among others, related to autoantibodies and abnormal B-cell proliferation, for example monoclonal gammopathy. The diagnosis of acquired C1 inhibitor deficiency is made on the basis of the medical history and on the level and activity of plasma C4, C1q, and C1 inhibitor. In case of high suspicion and a normal C1 inhibitor activity, it is recommended to repeat this test during an angioedema attack. Early diagnosis is important for the treatment of severe, potentially life-threatening attacks and to start prophylactic treatment in patients with frequent or severe angioedema attacks. PMID:23255023
Rhegmatogenous retinal detachment due to a macular hole in a patient with pars planitis: a case report
Stavrakas, Panagiotis; Androu, Angeliki A; Tranos, Paris; Kontou, Evgenia; Milia, Maria; Georgalas, Ilias
We report a rare case of rhegmatogenous retinal detachment due to a full-thickness macular hole in a young patient with pars planitis. This study was an interventional case report. A 38-year-old Asian man presented with acute reduction of vision in his left eye. His past ocular history revealed a precedent of two intravitreal steroid injections in his left eye, and fundoscopy revealed a total bullous retinal detachment along with 360░ snowbanking at the pars plana. Precise preoperative visualization of the posterior pole was impossible due to a dense nuclear cataract. During surgery, an unexpected full-thickness macular hole with no associated epiretinal membrane was observed, which resulted in the retinal detachment. This case of chronic pars planitis complicated with a full-thickness macular hole resulting in retinal detachment was successfully treated with vitrectomy, internal limiting membrane peeling, and perfluoropropane tamponade. Visual acuity improved from hand movements to 6/36 Snellen at 12 months postsurgery. This case report illustrates the rare but possible association between pars planitis with macular hole formation and subsequent retinal detachment, underlying the beneficiary outcome of vitrectomy surgery both diagnostically and therapeutically. PMID:25565856
Recurrent aborted sudden cardiac death with seizures and rhabdomyolysis due to bulimia-induced hypokalemia: report of one case.
Finsterer, Josef; St÷llberger, Claudia
Recurrent vomiting due to bulimia associated with abuse of furosemide and laxatives causing severe hypokalemia may result in recurrent aborted sudden cardiac death (SCD) and seizures. We report a 25-year-old female with a history of bulimia associated with abuse of furosemide and laxatives since the age of 15 years, migraine since puberty, renal abscesses at age 20 y, and rhabdomyolysis of unknown cause at age 24 y. She experienced aborted SCD due to severe hypokalemia with symptomatic seizures at 21 and 25 years of age. Bulimia patients additionally taking laxatives or furosemide are at particular risk of SCD and rhabdomyolysis and require periodic determination of electrolytes, potassium substitution, and adequate psychiatric therapy and surveillance. PMID:25327327
Validity of CaregiversÆ Reports on Head Trauma Due to Falls in Young Children Aged Less than 2 Years
Fujiwara, Takeo; Nagase, Hiroaki; Okuyama, Makiko; Hoshino, Takahiro; Aoki, Kazunori; Nagashima, Tastuya; Nakamura, Hajime
Objective: The clinical presentations of head trauma due to falls among young children aged less than 2 years are controversial, particularly in Japan, as the history of trauma recounted by a caretaker is not always reliable. The purpose of this study was to assess the validity of caregiverÆs reports on head trauma due to falls in young children aged less than 2 years in Japan. Methods: All patients <2 years of age presenting with head trauma resulting from a fall who were admitted to 3 childrenÆs hospitals in Japan from January 2001 to December 2005 were retrospectively reviewed (N = 58). The clinical presentations were compared among groups categorized by the heights from which the patient fell (short (?120 cm) or long (>120 cm)) and the surface on which the patient landed (carpet, tatami (Japanese mattress), hardwood floor, or concrete). Results: Patients who suffered short falls were more likely to present with subdural hemorrhage (SDH) than those who suffered long falls (74% and 40%, respectively, P = 0.027). More specifically, 62% of short falls showed SDH indicative of shaken baby syndrome (e.g. multilayer SDH). Neurological symptoms, cyanosis, and SDH were more commonly observed in patients who landed on carpeted or tatami surfaces than in those who landed on hardwood or concrete floors. Conclusions: Short falls and landing on soft surfaces resulted in the presentation of severer clinical symptoms than did long falls and landing on hard surfaces, suggesting that the validity of caretakersÆ reports on infant or young childrenÆs head trauma due to falls is low. Further research is warranted to investigate the cause of infant head trauma due to falls. PMID:23761991
First rib fracture and HornerÆs syndrome due to a motor vehicle collision: a case report
A case of a first rib fracture and Horner's syndrome due to a motor vehicle collision is reported. Initial evaluation in a hospital emergency department and follow-up by a medical primary care physician failed to provide identification of the HornerÆs syndrome. Careful assessment and review of the patientÆs symptoms, signs and images revealed this uncommon and important neurologic case presentation. A brief discussion related to traumatic first rib fracture, HornerÆs syndrome and arterial dissections of the neck is provided. PMID:23830309
Giant Urinary Bladder and Bilateral Giant Hydronephrosis due to Bladder Neck Obstruction: One Case Report and Literature Review
Tazi, Mohammed Fadl; Riyach, Omar; Ahallal, Youness; Mellas, Soufiane; Khallouk, Abdelhak; El Fassi, Mohammed Jamal; Farih, Moulay Hassan
Bilateral hydronephrosis secondary to urinary obstruction leads to a buildup of back pressure in the urinary tract and may lead to impairment of renal function. Cases of giant hydronephrosis are rare and usually contain no more than 1-2 litres of fluid in the collecting system. Here, we report a rarely seen case with giant urinary bladder and bilateral giant hydronephrosis due to bladder neck obstruction which contains 4000?mL fluid in the collecting system of the kidney mimicking an ascites in an adult male. PMID:22606637
Radiculopathy in the setting of lumbar nerve root compression due to an extradural intraforaminal lipoma: a report of 3 cases.
Loriaux, Daniel B; Adogwa, Owoicho; Gottfried, Oren N
A true adult spinal lipoma is an exceedingly rare cause of lumbar compression neuropathy. Only 5 cases of true extradural intraforaminal lipomas have been documented in the medical literature. The diagnostic criteria and treatment guidelines for this specific lipoma have yet to be established. This report features 3 histologically confirmed cases of extradural intraforaminal spinal lipomas that recently presented to the authors' practice. In addition, the literature was surveyed to include the 5 previously reported cases of true adult extradural intraforaminal spinal lipomas. The consistency in presentation, response to surgical intervention, and postoperative recovery in these 8 cases supports surgical intervention at the time of diagnosis. The authors' findings support elevated clinical suspicion, efficient diagnosis based on MRI, and early surgical intervention for this rare pathological entity. All cases presented in this report were symptomatic and occurred in the absence of other significant pathologies such as general spinal epidural lipomatosis, intradural lesions, tethering, or severe degenerative stenosis or herniated discs. The clinical, neuroradiological, and histological findings characteristic of a true adult extradural intraforaminal lipoma are emphasized to differentiate this lesion from the more common etiologies for lumbar compression neuropathy. Heightened awareness and clinical suspicion for the focal, foraminal spinal lipoma as a cause of radiculopathy symptoms will enable more efficient diagnosis and treatment. PMID:25840038
The use of biological mesh to repair one large, contaminated abdominal wall defect due to neoplastic invasion. Report of a case.
Galli, Davide; Goi, Gloria; Pariani, Dario; Moroni, Eliana; Danelli, Piergiorgio
We hereby report a case of use of biological mesh to repair one large, contaminated abdominal wall defect due to a sigmoid tumour presented as an abscess infiltrating the abdominal wall. Our patient was a 48-year-old woman. Her medical history was negative for any previous disease or surgical procedure. Because of the abscence of neoplastic secondarism an en-bloc resection of the interested sigmoid colon and of the infiltrated abdominal wall was performed, thus resulting a large wall defect in the left inguinal region. In order to close the wall defect a biological porcine collagen mesh was used. In our case we used a Permacol mesh made of porcine acellular dermal collagen. Reconstruction of complicated abdominal wall defects is a challenging surgical problem and primary repair is often difficult to achieve without excessive tension in the abdominal wall. The use of a syntethic mesh in this patient could have been inappropriate due to the possibility of creating adhesions with intra-abdominal viscera and fistula formation. We chose to use a biological mesh because of its safer properties in case of infected, inflamed or infiltrated surgical fields, as demonstrated in the literature. PMID:22462340
Prolonged hypothermia due to olanzapine in the setting of renal failure: a case report and review of the literature
Kansagra, Ankit; Patel, Sanket
Temperature dysregulation is an infrequent but previously documented adverse effect of antipsychotic medications. The majority of documented cases involve durations of hypothermia of less than 24 h. We present the case of a patient on therapeutic olanzapine for bipolar disease with dehydration from gastroenteritis leading to acute kidney injury in the setting of stage III chronic kidney disease, who presented with severe hypothermia of 31.2░C (88.2░F). He required active rewarming in the intensive care unit for a total of 9 days. This is the second case report of prolonged hypothermia from olanzapine in the setting of kidney disease. Clinicians should be aware that patients with renal dysfunction may be at increased risk for prolonged hypothermia from olanzapine. PMID:24294486
Life threatening central nervous system manifestations and hypothermia due to maneb intoxication in a child: a case report.
de Tollenaer, S M; Buysse, Cmp; van den Anker, J N; Touw, D J; de Hoog, M
Maneb, manganese ethylene-bis-dithiocarbamate, is a fungicide pesticide used in the agriculture and bulb flower culture sector. Toxicological effects for humans have been reported in literature and are diverse. They vary from allergic reactions (dermatitis, conjunctivitis, and bronchitis), central nervous system effects (muscarinic, nicotinic, central and extrapyramidal) and renal toxicity (acute renal failure).A 7-year old girl was admitted to the pediatric intensive care unit because of status epilepticus. Physical examination showed respiratory insufficiency, convulsions, and severe hypothermia (32.5 degrees C). The patient was intubated and her convulsions were successfully treated with benzodiazepines. Except for a combined metabolic and respiratory acidosis and hyperglycemia, diagnostic investigations on admission (full blood count, electrolytes, liver and renal functions, cerebrospinal fluid investigation, toxicology screening of blood and urine for barbiturates and benzodiazepines, blood culture, herpes PCR, and a CT scan of the brain) were normal. Within 24 hours, there was a complete recovery of all neurological signs. Within 72 hours, the patient was discharged from the hospital. Liquid chromatography-mass spectrometric investigation of her blood showed amounts of maneb, which can explain all symptoms and signs. However, effects of this magnitude on the central nervous system have not previously been reported in humans. PMID:17164699
Irreducible palmar metacarpophalangeal joint dislocation due to junctura tendinum interposition: a case report and review of the literature.
Patel, M R; Bassini, L
Three different anatomic structures have been reported to prevent reduction of a palmar dislocation of metacarpophalangeal joint: dorsal capsule, palmar plate, and a ruptured collateral ligament. In our case, extensor digitorum communis of the fifth finger and extensor digiti minimi subluxated on the ulnar side of the fifth metacarpal neck. Extensor digitorum communis of the fourth finger remained in its anatomic location. The junctura tendinum connecting the fourth and fifth extensor digitorum communis tendons slipped distal and then palmar to the metacarpal head, where it was trapped between the metacarpal neck and the base of the proximal phalanx. It was easily pulled out and the joint promptly reduced. Residual subluxation persisted due to rupture of the radial collateral ligament and the dorsal capsule. Repair restored joint reduction and stability. (J Hand Surg 2000; 25A:166-172. PMID:10642488
Acute intestinal obstruction due to Kalimate, a potassium-lowering agent: a case report and literature review.
Tongyoo, Assanee; Sriussadaporn, Ekkapak; Limpavitayaporn, Palin; Mingmalairak, Chatchai
Sodium polystyrene sulfonate (Kayexalate) and calcium polystyrene sulfonate (CPS, Kalimate) are commonly used to reduce serum potassium. There were some published evidences of severe gastrointestinal complications from the administration of these agents such as colonic necrosis with or without perforation and acute obstruction. The authors reported a 52-year-old male patient being critically ill from severe soft tissue infection of the right leg and sepsis. Hyperkalemia had occurred due to renal insufficiency and required several doses of Kalimate to reduce the serum potassium level. Subsequently, the patient developed complete intestinal obstruction and an exploratory laparotomy was performed. The intra-operative findings were distended stomach and the small bowel contained a large amount of intraluminal affected Kalimate that was removed via gastrotomy and enterotomy. These findings suggested that the inspissated Kalimate could lead to significant obstruction of the gastrointestinal tract in some groups of patient. PMID:24511728
Diffuse Calcification of the Urinary System and Miliary Tuberculosis Due To Delayed Diagnosis of Genitourinary Tuberculosis: A Case Report
CHEN, Hairong; LIU, Yubo; WU, Dawei
Genitourinary tuberculosis (GUTB) is difficult to diagnose in the earlier stage owing to the non-specific symptoms. Usually, renal tuberculous involvement is unilateral and the imaging finding is renal calcification, but associated calcifications of bilateral ureter and bladder are rare. We report a 66-year-old man who presented with diffuse calcification of the urinary system (including bilateral pelvicalyceal system, both ureters and bladder) and disseminated miliary tuberculosis due to GUTB. He had been misdiagnosed with urinary tract infection and urinary lithiasis for two years before the diagnosis of GUTB was confirmed by microbiological examination of the urine. This case highlights the importance of maintaining a high index of clinical suspicion for GUTB. PMID:25905063
Successful adalimumab treatment of a psoriasis vulgaris patient with hemodialysis for renal failure: A case report and a review of the previous reports on biologic treatments for psoriasis patients with hemodialysis for renal failure.
Kusakari, Yoshiyuki; Yamasaki, Kenshi; Takahashi, Toshiya; Tsuchiyama, Kenichiro; Shimada-Omori, Ryoko; Nasu-Tamabuchi, Mei; Aiba, Setsuya
The efficacy and safety of biologic treatments have been established in patients with moderate to severe psoriasis, but there are few reports on biologic therapy for patients with psoriasis complicated by end-stage renal failure on hemodialysis (HD). In this report, we demonstrated the efficacy and safety of adalimumab for patients with severe psoriasis on HD. A 46-year-old Japanese man with a 14-year history of psoriasis was referred to our clinic in September 2009. He had developed hypertension and renal failure during a 7-year history of cyclosporin treatment. With the infliximab treatment, he achieved 75% improvement of the Psoriasis Area and Severity Index (PASI) score within 3Āmonths from the PASI of 42.3 before the treatment. However, his renal failure gradually deteriorated, and HD was initiated at 1Āyear after the introduction of infliximab. Because of hydration during the i.v. injection of infliximab, he developed pulmonary edema with every infliximab treatment after starting HD. We switched to ustekinumab treatment, but his psoriasis was not improved. Then, we switched to adalimumab and achieved a PASI-100 response within 2Āmonths. The patient received adalimumab treatment for more than a year without any adverse effects. In addition to our case, five articles reported cases of psoriasis patients with renal failure on HD who were treated with biologics. The psoriatic lesions were improved by biologics in these cases, and no severe adverse effects on the renal function were reported. Thus, biologics are a reasonable treatment option for patients with severe psoriasis with renal failure on HD. PMID:25916786
[Complete remission of consciousness disturbances and spasticity due to a severe subarachnoid hemorrhage after intrathecal baclofen therapy: a case report].
Asahi, Takashi; Kashiwazaki, Daina; Koh, Masaki; Matsumura, Nobuhisa; Kuroda, Satoshi
Typically, intrathecal baclofen therapy(ITB)for spasticity is continuously required because the spasticity can recur if the ITB is stopped. Thus, an infusion pump for the ITB is permanently implanted. Some sporadic cases exhibiting remarkable improvements in their spasticity and consciousness disturbances have been reported after implanting the ITB pump. We experienced a rare case involving removal of the ITB pump after the spasticity resolved and the consciousness disturbances markedly improved. A 15-year-old girl developed a subarachnoid hemorrhage due to rupture of an aneurysm in the right anterior cerebral artery. Her initial Glasgow Coma Scale score was 4(E1V1M2). Trapping of the aneurysm and decompression craniotomy were performed. Subsequently, she underwent a tracheotomy, and a percutaneous gastrostomy(PEG)tube was implanted because of persistent consciousness disturbances. Cranioplasty and lumbar-peritoneal shunt for normal pressure hydrocephalus were performed after 1 month. An ITB pump was implanted to improve the spasticity observed mainly in the lower extremities 61 days after hemorrhage onset. Right hemiparesis remained due to Kernohan's notch. After transfer to the rehabilitation hospital, her consciousness disturbances and spasticity remarkably improved(1.9 to 1.0 and 3.5 to 1.0 on the Ashworth scale for the upper and lower extremities, respectively). The tracheostomy and PEG tubes were removed, and the baclofen dose was gradually reduced. She was completely off baclofen after 7 months, and she was discharged with a short leg brace and a cane for walking. The baclofen pump was then removed. In this case, temporary ITB improved the spasticity and consciousness disturbances. PMID:25748812
Hemolytic disease of the newborn due to anti-jkb: case report and review of the literature.
Velasco RodrĒguez, Diego; Pķrez-Segura, G; Jimķnez-Ubieto, A; RodrĒguez, M A; Montejano, L
Although anti-Jkb is a well-defined cause of severe acute or delayed hemolytic transfusion reactions, it is rarely associated with severe Hemolytic Disease of the Newborn (HDN), even with high antibody titer. To date, only 13 cases have been reported, so the possible reasons for that still remain unclear. Most of HDN due to anti-Jkb are mild-to-moderate, and usually have a good prognosis. A 41-years-old woman, who had a positive antibody screening test in her 13th week of pregnancy, was sent to the blood bank for study before an amniocentesis. Antibody identification and red blood cell (RBC) phenotyping of the patient and his husband were performed, plus arrays study in the amniotic fluid. An anti-Jkb was identified in the patient's serum with a titer of 1:1, and her RBC phenotype was O Rh(D) positive, C(+), c(+), E(-), e(+), K(-), Jka(+), Jkb(-). The RBC genotype of the fetus was B Rh(D) positive, Jka(+), Jkb(+). Antibody titer remained stable and the pregnancy was uneventful. At birth, there was no need of phototherapy or exchange transfusion for the newborn and her Jk(b+) typing result was confirmed in a cord blood sample. Although most of HDN cases due to anti-Jkb have a good outcome, monitoring antibody titer should be done to prevent fatal complications. Furthermore, antenatal antibody screening should be performed in every pregnant woman irrespective of her Rh(D) antigen status in order to detect red cell alloimmunization to other clinically significant blood group antigens. PMID:24839369
Mood disorder with mixed, psychotic features due to vitamin b12 deficiency in an adolescent: case report
Vitamin B12 is one of the essential vitamins affecting various systems of the body. Reports of psychiatric disorders due to its deficiency mostly focus on middle aged and elderly patients. Here we report a case of vitamin B 12 deficiency in a 16-year old, male adolescent who presented with mixed mood disorder symptoms with psychotic features. Chief complaints were ōirritability, regressive behavior, apathy, crying and truancyö which lasted for a year. Premorbid personality was unremarkable with no substance use/exposure or infections. No stressors were present. The patient was not vegetarian. Past medical history and family history was normal. Neurological examination revealed glossitis, ataxia, rigidity in both shoulders, cog-wheel rigidity in the left elbow, bilateral problems of coordination in cerebellar examination, reduced swinging of the arms and masked face. RombergÆs sign was present. Laboratory evaluations were normal. Endoscopy and biopsy revealed atrophy of the gastric mucosa with Helicobacter Pylori colonization. Schilling test was suggestive of malabsorbtion. He was diagnosed with Mood disorder with Mixed, Psychotic Features due to Vitamin B12 Deficiency and risperidone 0.5?mg/day and intramuscular vitamin B12 500 mcg/day were started along with referral for treatment of Helicobacter pylori. A visit on the second week revealed no psychotic features. RombergÆs sign was negative and cerebellar tests were normal. Extrapyramidal symptoms were reduced while Vitamin B12 levels were elevated. Risperidone was stopped and parenteral Vitamin B12 treatment was continued with monthly injections for 3?months. Follow-up endoscopy and biopsy at the first month demonstrated eradication of H. pylori. He was followed monthly for another 6?months and psychiatric symptoms did not recur at the time of last evaluation. Despite limitations, this case may underline the observation that mood disorders with psychotic features especially with accompanying extrapyramidal symptoms lacking a clear etiology may be rare manifestation of vitamin B12 and/or folate deficiency in children and adolescents and be potentially amenable to treatment. PMID:22726236
No Previous Public Services Required
ERIC Educational Resources Information Center
Taylor, Kelley R.
In 2007, the Supreme Court heard a case that involved the question of whether a school district could be required to reimburse parents who unilaterally placed their child in private school when the child had not previously received special education and related services in a public institution ("Board of Education v. Tom F."). The Court's 4-4ģ
Cutaneous paragonimiasis due to triploid Paragonimus westermani presenting as a non-migratory subcutaneous nodule: a case report
Introduction Paragonimiasis is a food-borne infection caused by Paragonimus parasites. The lungs and pleura are the primary sites for the infection; however, ectopic infection can occur in other organs such as skin, liver and brain. It is difficult to make a diagnosis of ectopic paragonimiasis due to an ignorance of, and unfamiliarity with the disease. We report the case of a patient with subcutaneous paragonimiasis diagnosed by histopathological analysis and serological testing. Case presentation A 39-year-old Chinese immigrant woman presented with a subcutaneous nodule in her left lower back. The nodule was initially suspected of lipoma and she was followed up on without any treatment. However, it gradually indurated and the nodule was resected surgically. A magnetic resonance imaging scan revealed a polycystic lesion with inhomogeneous low or high intensity on T1- or T2-weighted images, respectively. The rim of the lesion was enhanced after contrast enhancement, but the inside did not show high-signal intensity. A histological analysis of the surgically resected specimen revealed variable-sized tubulo-cystic structures. The cyst wall showed a granulomatous change with scant eosinophilic infiltration. A number of parasite ova were observed in the necrotic tissue inside the cysts, and a parasite body with a presumed oral sucker and reproductive organ was also detected, suggesting a trematode infection. A subsequent serological examination showed a positive reaction of her serum to the Paragonimus westermani antigen. No abnormal findings were found on her chest computed tomography scan. The diagnosis of subcutaneous paragonimiasis caused by Paragonimus westermani was made. Conclusions We report a case presenting only as a non-migratory subcutaneous nodule without any pleuropulmonary lesion, which was initially suspected of lipoma but denied by magnetic resonance imaging scan results. The case was subsequently diagnosed as subcutaneous paragonimiasis from the results of histopathological analysis and serological testing. PMID:25322860
Minimally invasive presacral approach for revision of an Axial Lumbar Interbody Fusion rod due to fall-related lumbosacral instability: a case report
Introduction The purpose of this study was to describe procedural details of a minimally invasive presacral approach for revision of an L5-S1 Axial Lumbar Interbody Fusion rod. Case presentation A 70-year-old Caucasian man presented to our facility with marked thoracolumbar scoliosis, osteoarthritic changes characterized by high-grade osteophytes, and significant intervertebral disc collapse and calcification. Our patient required crutches during ambulation and reported intractable axial and radicular pain. Multi-level reconstruction of L1-4 was accomplished with extreme lateral interbody fusion, although focal lumbosacral symptoms persisted due to disc space collapse at L5-S1. Lumbosacral interbody distraction and stabilization was achieved four weeks later with the Axial Lumbar Interbody Fusion System (TranS1 Inc., Wilmington, NC, USA) and rod implantation via an axial presacral approach. Despite symptom resolution following this procedure, our patient suffered a fall six weeks postoperatively with direct sacral impaction resulting in symptom recurrence and loss of L5-S1 distraction. Following seven months of unsuccessful conservative care, a revision of the Axial Lumbar Interbody Fusion rod was performed that utilized the same presacral approach and used a larger diameter implant. Minimal adhesions were encountered upon presacral re-entry. A precise operative trajectory to the base of the previously implanted rod was achieved using fluoroscopic guidance. Surgical removal of the implant was successful with minimal bone resection required. A larger diameter Axial Lumbar Interbody Fusion rod was then implanted and joint distraction was re-established. The radicular symptoms resolved following revision surgery and our patient was ambulating without assistance on post-operative day one. No adverse events were reported. Conclusions The Axial Lumbar Interbody Fusion distraction rod may be revised and replaced with a larger diameter rod using the same presacral approach. PMID:21959081
Epidemiology and outcome of systemic infections due to saprochaete capitata: case report and review of the literature.
Mazzocato, S; Marchionni, E; Fothergill, A W; Sutton, D A; Staffolani, S; Gesuita, R; Skrami, E; Fiorentini, A; Manso, E; Barchiesi, F
A case of systemic infection due to Saprochaete capitata in a patient with chronic lymphocytic leukemia is described. A review of the literature was conducted to identify all reported cases of this infection described between 1977 and August 2013. One hundred and four cases (included the present one) were identified. The median age of the patients was 56 years and 56% were males. Comorbidities included acute myeloid leukemia (52%), acute lymphoid leukemia (22%), other hematological malignancies (13%) and non-hematological diseases (9%). At the time of the infection, 82% of the patients were neutropenic. In 75% of the cases, the yeast was isolated from blood culture, in 25% from other sterile sites. Empirical treatment was done in 36% of the cases. Fifty-eight percent of the individual cases were treated with a combination or a sequential antifungal therapy. Amphotericin B was the antifungal drug most commonly used, followed by voriconazole and itraconazole. The overall crude mortality was 60%. Saprochaete capitata causes life-threatening infections in neutropenic patients. This comprehensive literature review may help the clinician to optimize the management of this rare infection. PMID:25078793
[Intravesical instillation of Maalox for the treatment of bladder hemorrhage due to prostate cancer invasion: report of two cases].
Hongo, F; Saitoh, M
Two cases treated by intravesical instillation of Maalox for bladder hemorrhage are reported. A 79-year-old man and an 81-year-old man were admitted because of macroscopic hematuria and bladder tamponade. In both cases, bladder hemorrhage caused by bladder invasion of prostate cancer had not improved after bladder lavage, intravenous drip infusion and medication of hemostatics. In the first case, bladder hemorrhage had decreased 4 days after the intravesical instillation of 50-100 ml Maalox for an hour per day. In the second case, irrigation of Maalox was performed because of the difficulty of intravesical instillation of Maalox due to irritable bladder. The bladder hemorrhage had not completely disappeared but improved 5 days after the bladder irrigation of 100 ml of Maalox with 100 ml of 0.9% NaCl for an hour per day. This method is easy and can be performed without complications. This method might be useful as first-line therapy in the case of severe bladder hemorrhage. PMID:10410323
Identifying questions in the American Association of Swine Veterinarian's PRRS risk assessment survey that are important for retrospectively classifying swine herds according to whether they reported clinical PRRS outbreaks in the previous 3 years.
Holtkamp, Derald J; Lin, Hui; Wang, Chong; O'Connor, Annette M
The American Association of Swine Veterinarian's (AASV) Production Animal Disease Risk Assessment Program (PADRAP) is a web-based program that offers a set of risk assessment surveys being used by veterinarians who are members of the AASV. Members use PADRAP to help producers systematically assess risk factors that may be associated with clinical outcomes. As assessments are performed the completed surveys are added to the dataset maintained at the Iowa State University College of Veterinary Medicine. One of the surveys included in PADRAP is the porcine reproductive and respiratory syndrome (PRRS) Risk Assessment for the Breeding Herd. The aim of the study was to categorize questions in version 2 of the PRRS Risk Assessment for the Breeding Herd survey as important or unimportant for classifying herds according to whether they reported clinical PRRS outbreaks in the previous 3 years. The results elucidate the relative importance of risk factors and areas of risk factors for clinical outcomes and removing unimportant questions may reduce the time required to complete the survey without affecting the quality of information obtained. Surveys from 896 sow herd sites in the United States and Canada completed between March 2005 and March 2009 were included in the analysis. The survey contained a large number of questions with a complex correlation structure among the questions. Responses for several questions were dependent upon responses to others. To address these issues, an approach was developed using a series of statistical methods including random forest, principle component analysis, logistic regression and receiver operating characteristic (ROC) analysis to classify the herds using the questions in the survey as explanatory variables. Questions were ranked by importance and systematically excluded from least important to most important. The questions excluded, without significantly affecting the performance of the model for classifying herds were identified as unimportant. Thirty-eight of the 127 questions analyzed were identified as unimportant for classifying herds according to whether they reported clinical PRRS outbreaks in the previous 3 years. Sections of the survey where a large number of questions were identified as unimportant included (1) entry of semen into the breeding herd and (2) transportation of live animals. Sections with a high percentage of questions identified as unimportant included (1) characteristics of the site, (2) disposal of dead animals and waste management and (3) employee and visitors. PMID:22475927
Cutaneous abscess due to Eubacterium lentum in injection drug user: a case report and review of the literature.
Lattuada, Emanuela; Zorzi, Antonella; Lanzafame, Massimiliano; Antolini, Dario; Fontana, Roberta; Vento, Sandro; Concia, Ercole
We described the first case, to the best of our knowledge, of cutaneous abscess due to Eubacterium lentum in a parenteral drug user, after complete fracture of the right femor. The case underlines the importance of carefully performed microbiological tests, due to the peculiar cultural needs of the micro-organism. PMID:16038756
First U.S. report of shellfish harvesting closures due to confirmed okadaic acid in Texas Gulf coast oysters
Jonathan R. Deeds; Kirk Wiles; Gary B. Heideman VI; Kevin D. White; Ann Abraham
Between March 7 and April 12, 2008, several bay systems on the east (Gulf of Mexico) coast of Texas, USA were closed to the harvesting of oysters (Crassostrea virginica) due to the presence of the DSP (Diarrheic Shellfish Poisoning) toxin okadaic acid in excess of the 20Ā?g\\/100Āg tissue FDA regulatory guidance level. This was the first shellfish harvesting closure due
Guerrero, H.; Restivo, M.
In-situ decommissioning of Reactors P- and R- at the Savannah River Site will require filling the reactor vessels with a special concrete based on materials such as magnesium phosphate, calcium aluminate or silica fume. Then the reactor vessels will be overlain with an 8 ft. thick layer of Ordinary Portland Cement (OPC) steel reinforced concrete, called the 'Cap Concrete'. The integrity of this protective layer must be assured to last for a sufficiently long period of time to avoid ingress of water into the reactor vessel and possible movement of radioactive contamination into the environment. During drying of this Cap Concrete however, shrinkage strains are set up in the concrete as a result of diffusion and evaporation of water from the top surface. This shrinkage varies with depth in the poured slab due to a non-uniform moisture distribution. This differential shrinkage results in restraint of the upper layers with larger shrinkage by lower layers with lesser displacements. Tensile stresses can develop at the surface from the strain gradients in the bulk slab, which can lead to surface cracking. Further, a mechanism called creep occurs during the curing period or early age produces strains under the action of restraining forces. To investigate the potential for surface cracking, an experimental and analytical program was started under TTQAP SRNL-RP-2009-01184. Slab sections made of Cap Concrete mixture were instrumented with embedded strain gages and relative humidity sensors and tested under controlled environmental conditions of 23 C and relative humidities (RH) of 40% and 80% over a period of 50 days. Calculation methods were also developed for predictions of stress development in the full-scale concrete placement over the reactor vessels. These methods were evaluated by simulating conditions for the test specimens and the calculation results compared to the experimental data. A closely similar test with strain gages was performed by Kim and Lee for a concrete mixture that did not employ humidity sensors and the admixtures used in this program. Yuan and Wan tried to predict the shrinkage strains and stresses in the Kim and Lee experiment, but did not include a creep analysis. Grasley and Lange conducted full restraint load tests on a concrete prism instrumented with humidity sensors over a 7 day curing period. The hypothetical case of full-scale placement of the Cap Concrete was also analyzed using the developed analytical methods. The calculation performed in this report is for scoping purposes only.
Initial nuclear radiation environments due to tactical nuclear weapons detonated in air-over-ground and air-over-sea geometries. Technical report
Calculations of the free-field neutron and secondary gamma-ray environments generated by the detonation of tactical standard-fission-weapons have been made for air-over-ground and air-over-seawater geometries. These data have been combined with previously published calculations of the radiation environments due to the primary prompt gamma-ray component, in order to predict the total radiation intensities induced along the air-ground interface, for various heights
High prevalence in Switzerland of pure red-cell aplasia due to anti-erythropoietin antibodies in chronic dialysis patients: report of five cases
Carlo Schonholzer; Gerald Keusch; Luzia Nigg; Dominique Robert; Jean-Pierre Wauters
Background. Pure red-cell aplasia (PRCA) after eryth- ropoietin (Epo) administration due to the appearance of neutralizing anti-Epo antibodies has been reported in over 200 cases between 1998 and 2002. However, large intercountry disparities were observed in the occurrence of this syndrome. Methods. On behalf of the Swiss Society of Nephrology, a survey was conducted in all the dialysis units of
Lessons learned from previous dengue outbreaks
Wiwanitkit, Viroj
Dengue is an important tropical infection caused by an arbovirus dengue. As a mosquito borne infection, this disease is widely spread in several tropical endemic countries. Millions of world populations are at risk for this arboviral infection. Each year, thousands of dengue infections are reported and there are several death cases. Each year, the outbreaks of dengue emerge in several countries and this implies the global importance of this infection. Fighting with dengue outbreak is important in public health. In this specific chapter, the author discussed lessons learned from previous dengue outbreaks.
[Successful treatment of dysphagia due to Wallenberg syndrome using intermittent air stretching method with balloon catheter: a case report].
Miyamoto, Junichi; Niijima, Kyo; Kubo, Yousuke; Miyazaki, Hiroko; Iguchi, Fukuichiro
A 69-year-old woman presented with dysphagia due to Wallenberg syndrome. Videofluorography revealed unilateral dysfunction of the cricopharyngeal muscle, which caused stenosis of the esophageal entrance on the affected side. Pharyngeal fiberscopy indicated that glottal function and the cough reflex were preserved and that the pharyngeal reflex was lost. The stenosis of the esophageal entrance due to dysfunction of the cricopharyngeal muscle on the affected side and the loss of the pharyngeal reflex were considered to cause the patient's dysphagia. Based on above mentioned findings, the intermittent air stretching method with balloon catheter(IASM)was performed. As a result, dysphagia showed rapid improvement without any complications such as aspiration or bleeding. Thus, the IASM may be effective in some cases of dysphagia due to Wallenberg syndrome. PMID:24598872
Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
Ozkaya, Hande Mefkure; Keskin, Fatma Ela; Haliloglu, Ozlem Asmaz; Senel, Tugba Elif; Kadioglu, Pinar
A 47-year-old woman presented with the complaints of nausea, vomiting, and weight loss. She had a history of bilateral surrenalectomy due to Cushing's syndrome. On examination she had tachycardia and orthostatic hypotension. Laboratory examinations revealed hypercalcemia and suppressed parathyroid hormone levels. She also had thyrotoxicosis due to Graves' disease. The investigations to rule out a malignancy were negative. With steroid, zoledronic acid, and antithyroid drug treatment her symptoms were resolved and calcium level was normalized. This case highlights the importance of recognizing thyrotoxicosis and concomitant adrenal failure as a possible cause of severe hypercalcemia. PMID:25878906
Inducible clindamycin resistance due to expression of erm genes in Staphylococcus aureus: report from a tertiary care Hospital Karachi, Pakistan
Naima Fasih; Seema Irfan; Afia Zafar; Erum Khan; Rumina Hasan
OBJECTIVE: To assess the frequency of phenotypic expression of inducible resistance of clindamycin due to expression of erm genes, in clinical isolates of Staphylococcus aureus (S. aureus), by double disk diffusion test (D-test).METHOD: This was a cross sectional study conducted in the clinical laboratory of Aga Khan University Hospital, Karachi. A total of 2432, non duplicate clinical isolates of S.
Parental Perceptions of Their Experiences with Due Process in Special Education. A Preliminary Report. RIEP-Print No. 99.
ERIC Educational Resources Information Center
Mitchell, Sibyl
Examined were the expectations and characteristics of the parents in 25 families involved with due process concerning the education of their learning disabled, emotionally disturbed, gifted, or speech impaired children (7-21 years old). Families availing themselves of the appeals process under Chapter 766 (a Massachusetts law providing for theģ
Cervical myelopathy due to chronic overshunting in a pediatric patient: case report and review of the literature.
Ulrich, Nils Harry-Bert; Maier, Matthias; Bernays, Rene-Ludwig; Krayenbuhl, Niklaus; Kollias, Spyros
We present a rare cause of cervical myelopathy produced by an engorged suboccipital epidural venous plexus due to chronic cerebrospinal fluid (CSF) overdrainage. A 17-year-old boy with obstructive hydrocephalus due to a retrocerebellar cyst and secondary implantation of a ventricloperitoneal shunt (VP-shunt) presented with progressive spastic tetraparesis. MRI imaging revealed myelopathy due to significant compression of the cervical spinal cord by engorged epidural veins. Further assessment at a low-pressure setting revealed a broken shunt valve. The VP-shunt valve was changed with an additional anti-siphon device leading to a gradual increase of the intracranial pressure (ICP). After intensive physiotherapy, the patient showed slight clinical improvement. Follow-up imaging within nine days showed distinct regression of the dilated venous plexus at the cranial-cervical junction (CCJ) with the resolution of cord compression. Engorgement of the epidural venous plexus should always be considered in the differential diagnosis of myelopathy in long-term shunt patients even when classical clinical and radiological signs of overshunting are missing. PMID:23756987
Case Report: Severe Hemolytic Disease of the Newborn Due to anti-Dib Treated with Phototherapy and Intravenous Immunoglobulin
Eun-Jee Oh; Dong Wook Jekarl; Hyun-Sik Jang; Hae-Il Park; Yeon-Joon Park; Hyun Ah Choi; Chung-Sik Chun; Yonggoo Kim; Hyung Hoi Kim
The Di b antigen usually occurs with high incidence, except in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Dib is not severe and its clinical course is benign. We report a Korean neonate with severe hemolytic disease of the newborn caused by anti-Dib. The phenotype and genotype of the Diego blood group system of the
Specific GC¢MS\\/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC¢MS\\/MS reports
Dimitrios Tsikas; Alexander Zoerner; Anja Mitschke; Yahya Homsi; Frank-Mathias Gutzki; Jens Jordan
Nitrated unsaturated fatty acids including nitro-oleic acid (NO2-OA) have been measured in human blood samples in their free and esterified forms. Plasma concentrations in healthy subjects have been reported to be of the order of 600nM for free NO2-OA and 300nM for esterified NO2-OA, as measured by LC¢MS\\/MS. In the present article we report a GC¢MS\\/MS method for the specific
Case report of a near medical event in stereotactic radiotherapy due to improper units of measure from a treatment planning system
Gladstone, D. J.; Li, S.; Jarvis, L. A.; Hartford, A. C. [Division of Radiation Oncology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756 (United States); Division of Radiation Oncology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756 and Department of Radiation Oncology, Temple University Hospital, Philadelphia, Pennsylvania 19104 (United States); Division of Radiation Oncology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756 (United States)
Purpose: The authors hereby notify the Radiation Oncology community of a potentially lethal error due to improper implementation of linear units of measure in a treatment planning system. The authors report an incident in which a patient was nearly mistreated during a stereotactic radiotherapy procedure due to inappropriate reporting of stereotactic coordinates by the radiation therapy treatment planning system in units of centimeter rather than in millimeter. The authors suggest a method to detect such errors during treatment planning so they are caught and corrected prior to the patient positioning for treatment on the treatment machine. Methods: Using pretreatment imaging, the authors found that stereotactic coordinates are reported with improper linear units by a treatment planning system. The authors have implemented a redundant, independent method of stereotactic coordinate calculation. Results: Implementation of a double check of stereotactic coordinates via redundant, independent calculation is simple and accurate. Use of this technique will avoid any future error in stereotactic treatment coordinates due to improper linear units, transcription, or other similar errors. Conclusions: The authors recommend an independent double check of stereotactic treatment coordinates during the treatment planning process in order to avoid potential mistreatment of patients.
Congenital fibrosis of extraocular muscle type 1A due to KIF21A mutation: first case report from Hong Kong.
Luk, H M; Lo, Ivan F M; Lai, Carmen W S; Ma, Louis C K; Tong, Tony M F; Chan, Daniel H C; Lam, Stephen T S
With the advancement of ophthalmological genetics, the molecular basis for more and more eye diseases can be elucidated. Congenital fibrosis of extraocular muscle (CFEOM) is an example. It is characterised by a congenital non-progressive restrictive ophthalmoplegia and ptosis. It is an autosomal dominant disease, caused by mutations of the KIF21A gene. With positive family history and typical ophthalmological findings, mutational analysis of KIF21A gene should be performed, not only to confirming the diagnosis, but also to offer a prognosis, for genetic counselling, and the possibility of prenatal diagnosis. Here we report the first KIF21A mutation associated with CFEOM1A in Hong Kong. PMID:23535681
Cardiovascular dysfunction due to sympathetic hypoactivity after complete cervical spinal cord injury: a case report and literature review.
Oh, Young-Min; Eun, Jong-Pil
Spinal cord injury (SCI) is one of the most devastating of all traumatic events; it may cause permanent dysfunction in several organ systems and lead to motor and sensory impairment. Cardiovascular dysfunction has been recognized to be the leading cause of morbidity and mortality in the acute and chronic stages following SCI. Although cardiovascular dysfunction causes the deaths of many SCI patients, most clinicians are unfamiliar with the phenomenon. The purpose of reporting our case is to remind clinicians to consider the possibility of cardiovascular dysfunction in patients with complete SCI. The patient signed informed consent for publication of this case report and any accompanying image. The ethical approval of this study was waived by the ethics committee of the Chonbuk National University Hospital, Jeonju, Korea, because this study was a case report and the number of patients was <3. A 63-year-old man was transferred to our emergency room after a fall. He complained of weakness and numbness of the lower extremity. Radiologic evaluation revealed C7/T1 unilateral facet dislocation with spinal cord contusion. On neurologic examination, the patient exhibited a paraplegic state below the T4 dermatome because of complete SCI. His vital signs were stable, but respiration was shallow. We performed intraoperative manual reduction and anterior interbody fusion. On the second postoperative day, the patient experienced sudden cardiac arrest after he was shifted from a supine to a semilateral position. Upon position change, heart rate was decreased <40 beats/min and blood pressure could not be checked. We immediately started cardiac massage and administered atropine 0.5?mg and epinephrine 1?mg, and the patient was successfully resuscitated. Cardiac arrest recurred when we performed endotracheal suction or changed patient's position. Echocardiographic and Holter monitoring findings demonstrated normal heart function and sinus bradycardia, and there was no evidence of pulmonary thromboembolism. We concluded that cardiac arrest was induced by sympathetic hypoactivity following complete SCI. Two months later, this phenomenon had resolved, and 4 months after presentation, he was discharged reliant on a home ventilator. Through this report, we emphasize that a thorough understanding of cardiovascular dysfunction following SCI is important for establishing a diagnosis and optimizing clinical outcomes. PMID:25816041
Small bowel perforation due to a migrated esophageal stent: Report of a rare case and review of the literature
Karagul, Servet; Yagci, Mehmet Ali; Ara, Cengiz; Tardu, Ali; Ertugrul, Ismail; Kirmizi, Serdar; Sumer, Fatih
Introduction Endoscopic esophageal stent placement is used to treat benign strictures, esophageal perforations, fistulas and for palliative therapy of esophageal cancer. Although stent placement is safe and effective method, complications are increasing the morbidity and mortality rate. We aimed to present a patient with small bowel perforation as a consequence of migrated esophageal stent. Presentation of case A 77-years-old woman was admitted with complaints of abdominal pain, abdominal distension, and vomiting for two days. Her past medical history included a pancreaticoduodenectomy for pancreatic tumor 11 years ago, a partial esophagectomy for distal esophageal cancer 6 months ago and an esophageal stent placement for esophageal anastomotic stricture 2 months ago. On abdominal examination, there was generalized tenderness with rebound. Computed tomography showed the stent had migrated. Laparotomy revealed a perforation localized in the ileum due to the migrated esophageal stent. About 5Ācm perforated part of gut resected and anastomosis was done. The patient was exitus fifty-five days after operation due to sepsis. Discussion Small bowel perforation is a rare but serious complication of esophageal stent migration. Resection of the esophagogastric junction facilitates the migration of the stent. The lumen of stent is often allow to the passage in the gut, so it is troublesome to find out the dislocation in an early period to avoid undesired results. In our case, resection of the esophagogastric junction was facilitated the migration of the stent and late onset of the symptoms delayed the diagnosis. Conclusion Patients with esophageal stent have to follow up frequently to preclude delayed complications. Additional technical procedures are needed for the prevention of stent migration. PMID:25967554
SBAR improves communication and safety climate and decreases incident reports due to communication errors in an anaesthetic clinic: a prospective intervention study
Randmaa, Maria; MÕrtensson, Gunilla; Leo Swenne, Christine; Engstr÷m, Maria
Objectives We aimed to examine staff membersÆ perceptions of communication within and between different professions, safety attitudes and psychological empowerment, prior to and after implementation of the communication tool Situation-Background-Assessment-Recommendation (SBAR) at an anaesthetic clinic. The aim was also to study whether there was any change in the proportion of incident reports caused by communication errors. Design A prospective intervention study with comparison group using preassessments and postassessments. Questionnaire data were collected from staff in an intervention (n=100) and a comparison group (n=69) at the anaesthetic clinic in two hospitals prior to (2011) and after (2012) implementation of SBAR. The proportion of incident reports due to communication errors was calculated during a 1-year period prior to and after implementation. Setting Anaesthetic clinics at two hospitals in Sweden. Participants All licensed practical nurses, registered nurses and physicians working in the operating theatres, intensive care units and postanaesthesia care units at anaesthetic clinics in two hospitals were invited to participate. Intervention Implementation of SBAR in an anaesthetic clinic. Primary and secondary outcomes The primary outcomes were staff membersÆ perception of communication within and between different professions, as well as their perceptions of safety attitudes. Secondary outcomes were psychological empowerment and incident reports due to error of communication. Results In the intervention group, there were statistically significant improvements in the factors æBetween-group communication accuracyÆ (p=0.039) and æSafety climateÆ (p=0.011). The proportion of incident reports due to communication errors decreased significantly (p<0.0001) in the intervention group, from 31% to 11%. Conclusions Implementing the communication tool SBAR in anaesthetic clinics was associated with improvement in staff membersÆ perception of communication between professionals and their perception of the safety climate as well as with a decreased proportion of incident reports related to communication errors. Trial registration ISRCTN37251313. PMID:24448849
[Disease due to work can be prevented more often; an alert report from The Netherlands Centre for Occupational Diseases].
Jungbauer, F H W
Epidemiologic data on occupational diseases in the Netherlands are scarce, partly because of the lack of 'risques professionnels' in the Dutch social security system. The Netherlands Centre for Occupational Diseases (NCvB) provides an annual overview of the occurrence and distribution of occupational diseases by sector and occupation. Like in other western countries, the number of reports of occupational diseases has decreased the last few years. Recent data, however, suggest a small increase. The NCvB also provides warning signals, which this centre believes should be known to health and safety policymakers and professionals so that they may respond with appropriate action. The report gives 4 different alerts: on the importance of health and safety awareness during vocational training, on scientific evidence in support of zero tolerance for intimidation and violence, on health and safety consultation regarding conception and pregnancy, which should focus on both men and women, and on the poor working conditions at the bottom end of the labour market. These alerts may also be of special interest to general practitioners and medical specialists because it is they who are primarily confronted with workers and their health problems as mentioned in the alerts. PMID:17373391
Are Nectarines to Blame? A Case Report and Literature Review of Spontaneous Bacterial Peritonitis Due to Listeria monocytogenes
How, Joan; Azar, Marwan M.; Meyer, Jaimie P.
Spontaneous bacterial peritonitis (SBP) is a frequent and potentially deadly complication of ascites in patients with end-stage liver disease. Unlike other pathogens more commonly implicated in SBP, Listeria monocytogenes is a nonenteric organism that may be acquired either sporadically or in the setting of foodborne outbreaks. Listeria is an unusual cause of SBP that presents particular management challenges because of the organismÆs intrinsic resistance to first-line and empiric SBP treatment that would otherwise include third-generation cephalosporins. We present here a case of Listeria SBP in a 68-year-old man with previously unidentified cirrhosis. His infection occurred in the context of a nationwide fruit recall for Listeria contamination, prompting an epidemiologic investigation. After describing the case, we then review the extant literature on Listeria peritonitis. To date, no case studies on Listeria SBP have systematically described risk factors for Listeria acquisition. As incidence of Listeria SBP is increasing, however, knowledge of patient risk factors, especially foodborne exposure risks, may be important in preventing future episodes of Listeria SBP, and in accurately monitoring foodborne outbreaks. PMID:25960571
Fulminant systemic capillary leak syndrome due to C1 inhibitor deficiency complicating acute dermatomyositis: a case report
Introduction Dermatomyositis is a chronic inflammatory disorder characterized by muscular and dermatologic symptoms with variable internal organ involvement. This is the first report on a patient with acute dermatomyositis and fulminant systemic capillary leak syndrome. Case presentation A 69-year-old Caucasian woman with chronic dermatomyositis presented with clinical signs of severe hypovolemic shock and pronounced hemoconcentration (hematocrit, 69%). Her colloid osmotic pressure was 4.6mmHg. Following a bolus dose of prednisolone (500mg), fluid resuscitation was initiated. During volume loading, anasarca and acute respiratory distress rapidly developed. Echocardiography revealed an underfilled, hypokinetic, diastolic dysfunctional left ventricle with pericardial effusion but no signs of tamponade. Despite continued fluid resuscitation and high-dosed catecholamine therapy, the patient died from refractory shock 12Āhours after intensive care unit admission. A laboratory analysis of her complement system suggested the presence of C1 inhibitor deficiency as the cause for systemic capillary leakage. The post-mortem examination revealed bilateral pleural, pericardial and peritoneal effusions as well as left ventricular hypertrophy with patchy myocardial fibrosis. Different patterns of endomysial/perimysial lymphocytic infiltrations adjacent to degenerated cardiomyocytes in her myocardium and necrotic muscle fibers in her right psoas major muscle were found in the histological examination. Conclusions This case report indicates that acute exacerbation of chronic dermatomyositis can result in a fulminant systemic capillary leak syndrome with intense hemoconcentration, hypovolemic shock and acute heart failure. In the presented patient, the cause for diffuse capillary leakage was most probably acquired angioedema, a condition that has been associated with both lymphoproliferative and autoimmunologic disorders. PMID:24467750
Superior vena cava syndrome due to a leiomyosarcoma of the anterior mediastinum: A case report and literature overview
Labarca, E.; Zapico, A.; RĒos, B.; Martinez, F.; Santamarina, M.
INTRODUCTION Leiomyosarcomas are an infrequent cause of malignant superior vena cava syndrome (VCS). PRESENTATION OF CASE A 51-year old male patient was admitted for a three-day history of dyspnoea, dysphagia and erythema of the head and neck. Computed tomography and magnetic resonance imaging showed a lesion arising on the anterior mediastinum, which was in close proximity with a thrombus in the superior vena cava. Surgical excision was performed, including open resection of the primary tumour and an atrio-innominate vein bypass with 8-mm polytetrafluoroethylene (PTFE). Histology confirmed a leiomyosarcoma and postoperative radiotherapy sessions were performed. Due to evidence of enlargement of the thrombus, a second intervention was undertaken. In this procedure, a remainder of the primary tumour was resected and the superior vena cava reconstructed with an autologous pericardium patch. The patient recovered satisfactorily and was discharged on the seventh postoperative day, with no evidence for relapse after 10 months of follow-up. DISCUSSION Leiomyosarcomas comprise less than 2% of the tumours of the mediastinum and are a rare cause of paraneoplastic VCS. Male patients in their sixties are most commonly affected. Relapses seem to be common, and thus a careful follow-up is often recommended. CONCLUSION In spite of the limited data on the management of thoracic leiomyosarcomas, surgery is currently considered the mainstay of treatment. PMID:25460453
Acute pulmonary emboli due to internal jugular vein thrombosis in papillary thyroid carcinoma, a case report and literature review.
Ataiekhorasgani, Masoud; Jafaripozve, Nasim
Upper extremity deep vein thrombosis (UEDVT) is a life threatening rare condition. Among the patients with UEDVT, internal jugular vein is accepted as uncommon thrombosis. Since internal jugular vein thrombosis (IJVT) is mostly underdiagnosed, a great attention is needed to diagnose the disease. A 75-year-old woman with history of dyspnea on exertion (DOE), weight loss and anorexia with the stable vital sign and right-sided cervical adenopathy with suspected thyroid nodule was admitted. One day after admission, sudden dyspnea was occurring with unstable vital sign and hypotension. Chest X-ray showed a bilateral pleural effusion. Pleural tap was exudative, CT scan showed bilateral pulmonary emboli. CT scan of the neck showed right-sided cervical adenopathy, heterogeneous thyroid and internal jugular vein thrombosis concomitant with superior thyroid vein thrombosis. The patient was treated with thrombolytic agent and enoxaparin followed by warfarin. Thyroid FNA revealed papillary thyroid carcinoma that followed by total thyroidectomy, histopathological examination verified papillary thyroid carcinoma. Although lower extremity DVT is the main cause of pulmonary emboli, but IJVT may be proceed by pulmonary embolism. Due to fatal outcome of pulmonary emboli in IJVT, color duplex sonography, is recommended in documented tumors or suspected history of malignancy. PMID:24592374
Sudden unexpected early neonatal death due to undiagnosed Hirschsprung disease enterocolitis: a report of two cases and literature review.
Peres, Luiz Cesar; Cohen, Marta Cecilia
Hirschsprung enterocolitis (HEC) is an uncommon, albeit well known, complication of Hirschsprung disease (HD). It is multifactorial and can appear in different age groups, but is particularly important in the neonatal period where it is characteristically seen in full-term neonates. Two cases of HEC are reported that were diagnosed at post-mortem examination, which presented as early sudden neonatal death, with a review the literature on fatal Hirschsprung enterocolitis. Case 1 was a 4-day old male neonate who was found unwell, struggling to breath, and with green vomitus. He was taken to hospital and pronounced dead a short time later. According to the parents meconium was passed on the first day. Post-mortem examination demonstrated necrotizing enterocolitis with isolated bowel perforation. Histology disclosed unsuspected HD. Case 2 was a 2-day old male neonate who was found wheezing with green vomitus. He arrived floppy, cyanosed, and in shock at the hospital and died a few hours later. Meconium was not passed, according to the parents. Post-mortem examination revealed necrotizing enterocolitis. There was also recto-sigmoidal aganglionosis and acetylcholinesterase staining confirmed HD. HEC is a multifactorial and sometimes recurrent complication of HD which characteristically develops in full-term neonates. Presentation with early sudden neonatal death is rare but should be considered in the diagnostic work-up of sudden deaths in this age group. PMID:23842858
Lung cancer patients with previous or simultaneous urologic cancers
Kunihiko Miyazaki; Hiroaki Satoh; Katsunori Kagohashi; Koichi Kurishima; Hiroichi Ishikawa; Morio Ohtsuka; Kiyohisa Sekizawa
Study objectives There have been few reports on clinical characteristics of lung cancer patients with previous or simultaneous urologic cancers.\\u000a Additionally, it was scarcely reported whether these patients could tolerate standard therapy. To evaluate them, we conducted\\u000a a retrospective study. Methods The records of patients with lung cancer who had previously or simultaneously urological cancers seen in our division between
A new species of Neolebouria Gibson, 1976 (Opecoelidae: Plagioporinae) from the whitecheek monocle bream, Scolopsis vosmeri (Perciformes: Nemipteridae), from the Panjim coast at Goa, with a checklist of parasites previously reported from this fish.
Jaiswal, Neeshma; Upadhyay, S K; Malhotra, Anshu; Blend, Charles K; Dronen, Norman O; Malhotra, Sandeep K
Neolebouria capoori n. sp. (Opecoelidae: Plagioporinae) is described from the whitecheek monocle bream, Scolopsis vosmeri (Bloch) (Perciformes: Nemipteridae) from the Panjim coast on the central west coast of India at Goa. The new species differs from both Neolebouria cantherhini (Li, Qiu & Zhang, 1988) as originally described from Thamnaconus modestus (G³nther) (syn. Cantherines modestus G³nther ) and Neolebouria confusum (Overstreet, 1969) as originally described from Ocyurus chrysurus (Bloch) by having the cirrus sac surpassing the ventral sucker posteriorly in N. cantherhini and being entirely preacetabular in N. confusum compared to terminating near the midlevel of the ventral sucker in N. capoori n. sp. The new species is most similar to N. confusum, but it further differs from this species by having the vitelline fields terminating near the level of the esophageal bifurcation compared to terminating near the level of the posterior margin of the pharynx, a larger sucker ratio (1:1.7-1:2.0 compared to 1:1.4-1:1.7), a somewhat shorter cirrus sac relative to body length (160-448, representing 9-18% of the body length compared to about 367, representing 22%), and the egg of the new species has a boss at the anopercular end that is not present in N. confusum. This study represents the first report on an opecoelid from S. vosmeri. A review of the parasites reported from S. vosmeri is included. PMID:24870995
Multi-organ dysfunction in bodybuilding possibly caused by prolonged hypercalcemia due to multi-substance abuse: case report and review of literature.
Schõfer, C N; Guldager, H; J°rgensen, H L
A 26-year-old male bodybuilder was admitted to the surgical department of a Danish community hospital for hematemesis. During the clinical interview, he revealed that he had recently finished a course of anabolic steroids and erythropoietin. The patient also had a previous history of infections and chronic ulcers due to paraffin-oil injections in both upper arms one year before. Over the course of the next few hours, the patient developed signs of multi-organ dysfunction, including pancreatitis, hemorrhagic gastritis, nephropathy with temporary anuria, and respiratory insufficiency, and was transferred to the ICU. After manometric monitoring on the patient's upper arms proved difficult, invasive blood pressure monitoring was used and revealed that the patient was in a state of hypertensive crisis. This case of multi-organ dysfunction was possibly caused by multi-substance-induced hypercalcemia. PMID:21072745
SRB Previously Released Data and Information
Atmospheric Science Data Center
SRB Previously Released Data and Information The Surface Radiation Budget (SRB) data sets listed on this page are previous releases. The most recent SRB Data Sets containing updated meteorological inputs are ordered from theĀ ...
Congestive Myelopathy due to Intradural Spinal AVM Supplied by Artery of Adamkiewicz: Case Report with Brief Literature Review and Analysis of the Foix-Alajouanine Syndrome Definition
Sood, Dinesh; Mistry, Kewal A.; Khatri, Garvit D.; Chadha, Veenal; Garg, Swati; Suthar, Pokhraj P.; Patel, Dhruv G.; Patel, Ankitkumar
Summary Background Spinal arteriovenous malformations (AVMs) can lead to development of congestive myelopathy (Foix-Alajouanine syndrome). Spinal AVMs are rare and so is this syndrome. Diagnosis is often missed due to its rarity and confusing definitions of the Foix-Alajouanine syndrome. Case Report We report a case of a 47-year-old male patient suffering from this rare syndrome with an AVM arising from the artery of Adamkiewicz, which is another rarity. Our patient was treated by embolization of the lesion with 20% glue, after which he showed mild improvement of symptoms. We also present a brief review of literature on spinal AVMs and elucidate the evolution of the term Foix-Alajouanine syndrome. Conclusions Use of the term ōFoix-Alajouanine syndromeö should be restricted to patients with progressive subacute to chronic neurological symptoms due to congestive myelopathy caused by intradural spinal AVMs. CT angiography should supplement DSA as preliminary Imaging modality. Patients may be treated with surgery or endovascular procedures. PMID:26171088
Effects of heading exposure and previous concussions on neuropsychological performance among Norwegian elite footballers
Straume-Naesheim, T; Andersen, T; Dvorak, J; Bahr, R
Background: Cross-sectional studies have indicated that neurocognitive performance may be impaired among football players. Heading the ball has been suggested as the cause, but recent reviews state that the reported deficits are more likely to be the result of head injuries. Objective: To examine the association between previous concussions and heading exposure with performance on computer based neuropsychological tests among professional Norwegian football players. Methods: Players in the Norwegian professional football league (Tippeligaen) performed two consecutive baseline neuropsychological tests (Cogsport) before the 2004 season (90.3% participation, n = 271) and completed a questionnaire assessing previous concussions, match heading exposure (self-reported number of heading actions per match), player career, etc. Heading actions for 18 players observed in two to four matches were counted and correlated with their self-reported values. Results: Neither match nor lifetime heading exposure was associated with neuropsychological test performance. Nineteen players scored below the 95% confidence interval for one or more subtasks, but they did not differ from the rest regarding the number of previous concussions or lifetime or match heading exposure. The number of previous concussions was positively associated with lifetime heading exposure (exponent (B) = 1.97(1.03¢3.75), p = 0.039), but there was no relation between previous concussions and test performance. Self-reported number of headings correlated well with the observed values (Spearman's ? = 0.77, p<0.001). Conclusion: Computerised neuropsychological testing revealed no evidence of neuropsychological impairment due to heading exposure or previous concussions in a cohort of Norwegian professional football players. PMID:16046359
Survey context and question wording affects self reported annoyance due to road traffic noise: a comparison between two cross-sectional studies
Background Surveys are a common way to measure annoyance due to road traffic noise, but the method has some draw-backs. Survey context, question wording and answer alternatives could affect participation and answers and could have implications when comparing studies and/or performing pooled analyses. The aim of this study was to investigate the difference in annoyance reporting due to road traffic noise in two types of surveys of which one was introduced broadly and the other with the clearly stated aim of investigating noise and health. Methods Data was collected from two surveys carried out in the municipality of Malm÷, southern Sweden in 2007 and 2008 (n = 2612 and n = 3810). The first survey stated an aim of investigating residential environmental exposure, especially noise and health. The second survey was a broad public health survey stating a broader aim. The two surveys had comparable questions regarding noise annoyance, although one used a 5-point scale and the other a 4-point scale. We used geographic information systems (GIS) to assess the average road and railway noise (LAeq,24h) at the participants' residential address. Logistic regression was used to calculate odds ratios for annoyance in relation to noise exposure. Results Annoyance at least once a week due to road traffic noise was significantly more prevalent in the survey investigating environment and health compared to the public health survey at levels > 45 dB(A), but not at lower exposure levels. However no differences in annoyance were found when comparing the extreme alternatives "never" and "every day". In the study investigating environment and health, "Noise sensitive" persons were more likely to readily respond to the survey and were more annoyed by road traffic noise compared to the other participants in that survey. Conclusions The differences in annoyance reporting between the two surveys were mainly due to different scales, suggesting that extreme alternatives are to prefer before dichotomization when comparing results between the two. Although some findings suggested that noise-sensitive individuals were more likely to respond to the survey investigating noise and health, we could not find convincing evidence that contextual differences affected either answers or participation. PMID:22404876
Investigation and analysis of a reported incident resulting in an actual airline hijacking due to a fanatical and engrossed VR state.
Ichimura, A; Nakajima, I; Juzoji, H
We begin this report by defining Chronic Alternate-World Disorder (CAWD) as a symptomatic behavior in which a person becomes fanatically engrossed in a virtual-reality (VR) world to the extent that he or she can no longer distinguish between the actual world and virtual reality. We then report on our investigation and provide an analysis and discussion of what we believe to be a case of CAWD. The case in question involves a perpetrator who hijacked a jumbo jetliner in order to fly the airplane on his own, after developing CAWD from the use of light-simulator software. Psychiatrists and physicians specializing in VR-related disorders have analyzed the case's psychological, social, and technical background based on previously disclosed information. We believe symptomatic cases of CAWD will increase as VR spreads throughout our society. In view of this, our objective is to propose precautionary and preventive measures for providers of VR systems for patients with schizophrenia or personality disorders, from psychiatric and sociological perspectives. PMID:11710260
Detection of cytomegalovirus in an immunocompetent adult presenting with acute retinal necrosis due to varicella-zoster virus: a case report
Nakamura, Tomoko; Daikoku, Tohru; Shiraki, Kimiyasu; Hayashi, Atsushi
Background To report a case of simultaneous detection of cytomegalovirus (CMV) in acute retinal necrosis (ARN) due to varicella-zoster virus (VZV) in an immunocompetent adult. Methods A 65-year-old healthy woman presented with necrotizing retinitis. Vitreous, tears, saliva, and swabs of the auricular and forehead skin areas were collected and tested by polymerase chain reaction analysis at various time points during the treatment period. Results VZV and CMV DNA were detected in the vitreous, tears, saliva, and skin. CMV was present in fewer copies than VZV in the vitreous. The retinal lesion clinically improved rapidly only by acyclovir. According to the clinical findings and the clinical responses to acyclovir, CMV seems not to cause ARN in this case. Conclusion VZV and CMV DNA were detected in the vitreous of a patient with VZV ARN. CMV reactivation appeared to be asymptomatic. PMID:25999692
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that well managed woodlands are able to deliver a wide range of goods and services and so we want to seeprint previous contents next page page Woodlands for Wales Action Plan 2010 - 2015 Showing progress of actions to March 2011 www.cymru.gov.uk #12;Woodlands for Wales Action Plan print previous contents next
Granulomatous infection due to Propionibacterium acnes mimicking malignant disease
J. Esteban; M. Cuenca-Estrella; J. M. Ramos; F. Soriano
Propionibacterium acnes is a gram-positive anaerobic bacillus that is a common inhabitant of the human skin. It has been implicated in pyogenie infections mainly relating to prosthetic devices (1), however a role of the organism in granulomatous infections is less common. We report a case of granulomatous infection due to Pro. pionibacteriurn acnes in a previously healthy young man. The
Stress Transfer due to the June 23, 2001, Arequipa, Peru, Earthquake and Previous Large Subduction Events
R. Robinson; R. Benites; L. Ocola; M. Stirling; R. Langridge; H. Aleman
The 23 June M 8.2 Arequipa, Peru earthquake complies to an observed general tendency of the of major earthquakes (M > 7.0) on the subduction thrust under central and southern Peru to migrate southwards. The region considered is about 1500 km in length. Our purpose in this study is to find if such a tendency is the result of stress-triggering
HERPETOLOGICAL NOTESHERPETOLOGICAL NOTES previously reported for any snake species.
Huey, Raymond B.
platyrhinos and Heterodon nasicus. Univ. KansasPubl. Mus. Nat. Hist. 18: 253-420. VISSER,J. 1966. Color change. nasicus appear to support this hy- pothesis. LITERATURECITED BURLESON, G. L. 1942. The source of the blood westernhognosesnakes(Heter- odon platyrhinosand H. nasicus). Unpubl. Ph.D. Dissert. Texas A&MUniversity, College
Completed Suicides and their Previous Attempts
ERIC Educational Resources Information Center
Lester, David; Beck, Aaron T.
Investigates the reliability of the findings of Ovenstone and Krietman (some completed suicides have attempted suicide previously, whereas other completed suicides have no such history) with a sample of completed suicides in the United States. (Author/RK)
A Quantitative Analysis of Previously Launched AdultsĀ
Farris, Demetrea Nicole
Young adults are moving back into their family homes and are now living with their parents. Common terms for the adult children include "previously launched adult" and "incompletely launched adult." I used data from Wave 3 (2001 to 2003...
Table 6.2 Change In the Vietnam/Non-Vietnam Odds Ratio Due to Adding Reporte!cI Childhood Behavior Problems and Drug Use In the Army to the Final LC"Jlstlc
Table 6.2 Change In the Vietnam/Non-Vietnam Odds Ratio Due to Adding Reporte!cI Childhood Behavior a Adjusted odds ratio for Vietnam relative to non-Vietnam. b Covariates include place of service, year
[Genodermatosis with changes in eyes not previously described (author's transl)].
Richard, G; Wreesmann, P
Report on a patient with several symptoms which had not previously occurred together. The main symptom is palmoplantar keratosis; further alterations were kypho-skoliosis, brachytelephalangia of the thumbs, and in the eyes, keratoconus, a cataract and electroretinographic alterations. PMID:6451760
Orthotopic cardiac transplantation in two patients with previous malignancy.
Hinkamp, T; Sullivan, H; Bakhos, M; Grieco, J; Pifarrķ, R
This report presents 2 patients with previous malignancy in whom congestive cardiomyopathy developed secondary to doxorubicin toxicity. Both patients underwent orthotopic cardiac transplantation 3 and 5 years ago and are now in functional class I with no evidence of malignant recurrence. PMID:2039297
Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review
The current study presents two cases of gastrointestinal (GI) bleeding due to pancreatic metastasis of non-small cell lung cancer (NSCLC). The two patients had a history of lung adenocarcinoma prior to pancreatic metastasis. The first patient presented with melena, epigastric pain and weight loss, and the second patient presented with melena and weight loss. The diagnoses were confirmed by biopsy of the metastatic lesions. Immunohistochemistry is useful for managing the differential diagnosis between lung cancer and pancreatic carcinoma in patients with a history of lung cancer. Chemotherapy prolonged the survival of the second patient. However, the first patient received no chemotherapy and succumbed to NSCLC six weeks after the diagnosis of metastatic pancreatic cancer. GI bleeding as a result of pancreatic metastasis of NSCLC is extremely rare; including the present two cases, only three cases have been reported in the English literature. The current study is presented in order to increase the awareness of GI hemorrhage as a manifestation of this relatively rare condition.
Babesiosis due to the canine Babesia microti-like small piroplasm in dogs - first report from Portugal and possible vertical transmission
Background Canine babesiosis (or piroplasmosis) is endemic in northern Portugal, but molecularly confirmed cases of infection with small piroplasms have not been reported in the country. Three German shepherd dogs - a bitch and its 2-month old pup and an unrelated male - clinically suspected of piroplasmosis were assessed for babesial infection. Results Parasitemia with small piroplasms was detected by microscopy in two dogs. All three dogs were positive by PCR and the Babesia microti-like small piroplasm (syn. Theileria annae) was identified by DNA sequencing. These are the first confirmed cases of babesiosis caused by the B. microti-like piroplasm both in dogs from Portugal and in dogs suspected of clinical piroplasmosis outside of Spain. Conclusions Although the bitch and the male had visited neighboring Galicia (northwestern Spain), where the disease is endemic, incursion of this piroplasm into northern Portugal is evident and infection of the non-traveled pup was due to either vertical transmission or autochthonous tick infection. PMID:21489238
Spinal cord compression due to primary intramedullary tuberculoma of the spinal cord presenting as paraplegia: A case report and literature review
Mishra, Sudhansu Sekhar; Das, Deepak; Das, Srikanta; Mohanta, Itibrata; Tripathy, Soubhagya Ranjan
Background: Spinal cord compression can be due to various causes but spinal intramedullary tuberculoma is a rare cause. We report a case that had an intramedullary spinal cord tuberculomas in which the diagnosis was made histologically, without evidence of symptoms of systemic tuberculosis. This lesion, located in the thoracic region, mimicked as an intramedullary tumor radiologically. Case Description: The patient was a 25-year-old male who presented with a history of progressive paraparesis. Initial diagnosis was made as an intramedullary tumor by magnetic resonance imaging (MRI). The treatment of the patient involved is complete surgical excision of intramedullary lesion followed by appropriate antituberculous therapy. Postoperatively, his neurological symptoms were dramatically improved. With combination of both surgical and medical treatments, excellent clinical outcome was obtained. Conclusion: This case illustrates the risk of misdiagnosis and the importance of histological confirmation of a pathological lesion as spinal cord tuberculoma prior to surgical therapy, which should be kept in mind as a differential diagnosis of the intramedullary spinal cord tumors. PMID:25883834
First Name* Middle Name Previous Last Name
Grishok, Alla
Last Name* First Name* Middle Name Previous Last Name Social Security Number* (no dashes) Date the international number field. Daytime* Evening* Mobile*(no dashes) (no dashes) (no dashes) Address* Number) *Specific Aims of your proposed "R" application and a one-page summary of the proposed research. List
First Name* Middle Name Previous Last Name
Grishok, Alla
Last Name* First Name* Middle Name Previous Last Name Social Security Number* (no dashes) Date the international number field. Daytime* Evening* Mobile*(no dashes) (no dashes) (no dashes) Address* Number Aims of your proposed "R" application and a one-page summary of the proposed research. List the broad
Hardware News and Reviews Previous post
Ruina, Andy L.
, designed to protect the robot in case of falls. The research team that built Ranger was aiming for distance That Looks Like You Jan. 25, 1979: Robot Kills Human Robot Band Backs Pat Metheny on Orchestrion Tour FollowGadget Lab Hardware News and Reviews Previous post Next post Adorable Walking Robot Sets Distance
GEOLOGY, April 2008 327 PREVIOUS WORK
GEOLOGY, April 2008 327 PREVIOUS WORK The Chesapeake Bay impact structure (Fig. 1) was identified in the following equation (modified from Steckler and Watts, 1978): TS = S* m -s( ) m - w( ) - SL m( ) m -w( ) + Wd thicknesses (S*), densities (s), and water depths (Wd), given the change in sea level (SL). The values of m
Cho, Tatsurai; Tatewaki, Masamitsu; Onishi, Shogo; Yokoyama, Tatsuya; Yoshida, Naruo; Fujimatsu, Takayoshi; Hirata, Hirokuni; Fukuda, Takeshi; Fukushima, Yasutsugu
We report a rare case of anaphylaxis due to caffeine intake. A 27-year-old woman suffered her first episode of anaphylaxis and a positive skin prick test suggested that the anaphylaxis was due to an IgE-mediated hypersensitivity reaction to caffeine. She was diagnosed with caffeine allergy and has not had an allergic reaction after avoiding foods and drinks containing caffeine. Although caffeine is known to have antiallergic effects, this case shows that caffeine can be an allergen and cause anaphylaxis. PMID:25653922
Laparoscopic cholecystectomy in a patient with situs inversus totalis and previous abdominal surgery.
Polychronidis, A; Karayiannakis, A; Botaitis, S; Perente, S; Simopoulos, C
Situs inversus totalis is a rare congenital defect that can present difficulties during laparoscopic surgery due to the mirror-image anatomy. We report a patient with symptomatic cholelithiasis and previous abdominal surgery in whom a chest X-ray revealed a right-sided heart, whereas abdominal ultrasound revealed that his gallbladder was located in the left hypochondrium. At surgery, the surgeon and the camera assistant were standing on the right-hand side of the patient, and the first assistant was standing on the left. The camera was introduced through an umbilical incision, and laparoscopy confirmed the situs inversus. The other 10-mm trocar was placed in the midline left of the falciform ligament and two 5-mm trocars were placed in the left subcostal midclavicular line and anterior axillary line, respectively. After dissection of multiple adhesions caused by previous abdominal surgery, a standard laparoscopic cholecystectomy was performed successfully. This report suggests that situs inversus is not a contraindication for laparoscopic surgery. However, the procedure is more difficult and potentially hazardous due to the mirror-image anatomy (particularly the transposition of biliary ducts) causing difficulties in orientation, so that extreme care is required to avoid iatrogenic injuries. Despite these factors, laparoscopic cholecystectomy can be performed safely in patients with situs inversus totalis. PMID:12165836
A case report of false negative Legionella test results in a chlorinated public hot water distribution system due to the lack of sodium thiosulfate in sampling bottles.
Wiedenmann, A; Langhammer, W; Botzenhart, K
We examined samples from the showers and the central water distribution system of a public building with an indoor swimming pool. The pool was used for school and recreational activities and as a sports therapy facility for patients with coronary heart disease. The building's hot water system was contaminated with Legionella pneumophila. Due to the building's intricate piping system, several attempts to completely eliminate legionellae by thermal and chemical disinfection had failed, so an external sanitation company was charged with the installation of a continuous chlorination device in order to keep Legionella concentrations low. The laboratory which was contracted by the sanitation company to monitor bacteria levels after installation of the chlorination device used sampling bottles without sodium thiosulfate and repeatedly reported an absence of Legionella. However, up to 69,000 colony forming particles (CFP) of Legionella pneumophila (Lp) per litre and up to 171 CFP/ml of heterotrophic bacteria could be detected when parallel samples were collected in bottles containing sodium thiosulfate at standard concentrations. Laboratories, epidemiologists, public health officials and technical staff who may be in charge of delivering, preparing or using sterile sampling devices for the collection of environmental samples to be tested for legionellae should be aware that cultures can return false negative results if the sampling containers used to collect chlorinated drinking water or chlorinated pool water samples do not contain a neutralizing agent to instantly inactivate residual halogen biocides. False negative results may lead to a false sense of security regarding the safety of water systems or the success of disinfection measures, and may thus endanger public health or even hinder the epidemiological clarification of outbreaks. PMID:11833297
Pregnancy hemoperitoneum and placenta percreta in a patient with previous pelvic irradiation and ovarian failure
Pridjian, G.; Rich, N.E.; Montag, A.G. (Univ. of Chicago, IL (USA))
Placenta percreta in a patient with previous pelvic irradiation has never been described. Reported is a case of placenta percreta with hemoperitoneum associated with a second-trimester incomplete abortion in a patient with previous pelvic irradiation and ovarian failure.
Previous Open Rotor Research in the US
NASA Technical Reports Server (NTRS)
VanZante, Dale
Previous Open Rotor noise experience in the United States, current Open Rotor noise research in the United States and current NASA prediction methods activities were presented at a European Union (EU) X-Noise seminar. The invited attendees from EU industries, research establishments and universities discussed prospects for reducing Open Rotor noise and reviewed all technology programs, past and present, dedicated to Open Rotor engine concepts. This workshop was particularly timely because the Committee on Aviation Environmental Protection (CAEP) plans to involve Independent Experts in late 2011 in assessing the noise of future low-carbon technologies including the open rotor.
Significance of previous year's weather for forest net ecosystem productivity
NASA Astrophysics Data System (ADS)
Zielis, S.; Etzold, S.; Zweifel, R.; Eugster, W.; Haeni, M.; Buchmann, N. C.
Understanding the response of forest net ecosystem productivity (NEP) to environmental drivers under climate change is highly relevant for predictions of annual forest carbon (C) flux budgets. Modeling annual forest NEP with climate-vegetation models, however, remains challenging due to unknown responses of forests to weather of the previous year. In this study, we address the influence of previous year's weather on the inter-annual variability of NEP for six European forests, including evergreen needleleaf forests (ENF) and deciduous broadleaf forests (DBF): Davos, Switzerland (ENF); Hyytiõlõ, Finland (ENF); Loobos, Netherlands (ENF); Soroe, Denmark (DBF); Tharandt, Germany (ENF); and Vielsalm, Belgium (DBF). We hypothesize, that previous year's weather significantly increases explained inter-annual variability of NEP in European forests, with a stronger influence on DBF than ENF. The strongest impact of previous year's weather was found in the subalpine Norway spruce forest at Davos, Switzerland, increasing the explained variance of NEP in linear models from 20% to 53%, with previous year's spring temperature promoting current year NEP strongly. Moreover, soil temperature in the current year's spring played a major role, controlling annual NEP mainly by influencing gross primary productivity (GPP) early in the year, with spring NEP accounting for 56% of annual NEP. Results from the other forests confirmed a forest ecosystem response to previous year's weather with one exception (Hyytiõlõ). In four of the five forests we were able to reveal an increase of explained variance of NEP when previous year's weather was considered in the analysis, ranging between 7% and 22%. Additionally, we found no trend towards a stronger response of DBF to previous year's weather, in contrast with our hypothesis. Our results suggest that considering responses of NEP to previous year's weather in climate-vegetation models is highly promising and allows for more precise estimates of annual C budgets of forest ecosystems. Upcoming research will focus on revealing site characteristics driving the observed differences in forest NEP response to previous year's weather, and thus, allowing for general conclusions on a larger spatial scale
Current Psychopathology in Previously Assaulted Older Adults
ERIC Educational Resources Information Center
Acierno, Ron; Lawyer, Steven R.; Rheingold, Alyssa; Kilpatrick, Dean G.; Resnick, Heidi S.; Saunders, Benjamin E.
Older adult women age 55+ years (N = 549) were interviewed as part of a population-based epidemiological research study of lifetime experiences with physical and sexual assault and current mental health problems. Although overall rates of psychopathology were low, producing very small cells for comparison, women who reported experiencing physicalģ
Residual stresses due to weld repairs, cladding and electron beam welds and effect of residual stresses on fracture behavior. Annual report, September 1, 1977November 30, 1978
The study is divided into three tasks. Task I is concerned with predicting and understanding the effects of residual stresses due to weld repairs of pressure vessels. Task II examines residual stresses due to an electron beam weld. Task III addresses the problem of residual stresses produced by weld cladding at a nozzle vessel intersection. The objective of Task I
Obinutuzumab for previously untreated chronic lymphocytic leukemia.
Abraham, Jame; Stegner, Mark
Obinutuzumab was approved by the Food and Drug Administration in late 2013 for use in combination with chlorambucil for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL). The approval was based on results of an open-label phase 3 trial that showed improved progression-free survival (PFS) with the combination of obinutuzumab plus chlorambucil compared with chlorambucil alone. Obinutuzumab is a monoclonal antibody that targets CD20 antigen expressed on the surface of pre B- and mature B-lymphocytes. After binding to CD20, obinutuzumab mediates B-cell lysis by engaging immune effector cells, directly activating intracellular death signaling pathways, and activating the complement cascade. Immune effector cell activities include antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. PMID:24971420
Books Average Previous Decade of Economic Misery
Bentley, R. Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios
For the 20th century since the Depression, we find a strong correlation between a æliterary misery indexÆ derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade. PMID:24416159
27 CFR 31.158 - Previously prescribed or approved records of receipt and disposition.
Code of Federal Regulations, 2011 CFR
...LIQUORS ALCOHOL BEVERAGE DEALERS Records and Reports Wholesale Dealers' Records and Reports ¦ 31.158 Previously prescribed or approved...of ¦ 31.155 or paragraph (a) of ¦ 31.156, as applicable. The records must be...
27 CFR 31.158 - Previously prescribed or approved records of receipt and disposition.
Code of Federal Regulations, 2010 CFR
...LIQUORS ALCOHOL BEVERAGE DEALERS Records and Reports Wholesale Dealers' Records and Reports ¦ 31.158 Previously prescribed or approved...of ¦ 31.155 or paragraph (a) of ¦ 31.156, as applicable. The records must be...
Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Antiandrogens
Orton, Frances; Rosivatz, Erika; Scholze, Martin; Kortenkamp, Andreas
Background Evidence suggests that there is widespread decline in male reproductive health and that antiandrogenic pollutants may play a significant role. There is also a clear disparity between pesticide exposure and data on endocrine disruption, with most of the published literature focused on pesticides that are no longer registered for use in developed countries. Objective We used estimated human exposure data to select pesticides to test for antiandrogenic activity, focusing on highest use pesticides. Methods We used European databases to select 134 candidate pesticides based on highest exposure, followed by a filtering step according to known or predicted receptor-mediated antiandrogenic potency, based on a previously published quantitative structure¢activity relationship (QSAR) model. In total, 37 pesticides were tested for in vitro androgen receptor (AR) antagonism. Of these, 14 were previously reported to be AR antagonists (ōactiveö), 4 were predicted AR antagonists using the QSAR, 6 were predicted to not be AR antagonists (ōinactiveö), and 13 had unknown activity, which were ōout of domainö and therefore could not be classified with the QSAR (ōunknownö). Results All 14 pesticides with previous evidence of AR antagonism were confirmed as antiandrogenic in our assay, and 9 previously untested pesticides were identified as antiandrogenic (dimethomorph, fenhexamid, quinoxyfen, cyprodinil, ?-cyhalothrin, pyrimethanil, fludioxonil, azinphos-methyl, pirimiphos-methyl). In addition, we classified 7 compounds as androgenic. Conclusions Due to estimated antiandrogenic potency, current use, estimated exposure, and lack of previous data, we strongly recommend that dimethomorph, fludioxonil, fenhexamid, imazalil, ortho-phenylphenol, and pirimiphos-methyl be tested for antiandrogenic effects in vivo. The lack of human biomonitoring data for environmentally relevant pesticides presents a barrier to current risk assessment of pesticides on humans. PMID:21310686
Bilateral retinal artery occlusion due to mitral valve prolapse.
van Rhee, F.; Blecher, T. E.; DeLepeleire, K. A.; Galloway, N. R.
We report a case of bilateral retinal artery occlusion due to mitral valve prolapse. Most patients with retinal ischaemia in whom it is found have not been previously known to have it. Since it is a common condition it would seem essential that it be included in the differential diagnosis of amaurosis fugax and retinal artery occlusion if future ischaemic events are to be prevented. All patients with retinal ischaemia should have a full cardiovascular examination supplemented by echocardiography. Images PMID:1854701
Coexistence of Obstructive Sleep Apnea and Superior Vena Cava Syndromes Due to Substernal Goitre in a Patient With Respiratory Failure: A Case Report
Tunc, Mehtap; Sazak, Hilal; Karlilar, Bulent; Ulus, Fatma; Tastepe, Irfan
Introduction: Substernal goiter may rarely cause superior vena cava syndrome (SVCS) owing to venous compression, and cause acute respiratory failure due to tracheal compression. Obstructive sleep apnea syndrome (OSAS) may rarely occur when there is a narrowing of upper airway by edema and vascular congestion resulting from SVCS. Case Presentation: We presented the clinical course and treatment of acute respiratory failure (ARF) developed in a patient with SVCS and OSAS due to substernal goiter. After treatment of ARF with invasive mechanical ventilation, weaning and total thyroidectomy were successfully performed through collar incision and median sternotomy without complications. Conclusions: Our case showed that if the respiratory failure occurred due to substernal goiter and SVCS, we would need to investigate the coexistence of OSAS and SVCS.
1979J2 - Discovery of a previously unknown Jovian satellite
NASA Technical Reports Server (NTRS)
Synnott, S. P.
Detailed examination of imaging data of Jupiter taken by Voyager 1 reveals a previously unknown satellite 1979J2. Analysis of the image on the Jovian disk indicates that it is not an atmospheric feature or the shadow of any known satellite. The orbital period is calculated at 16 hours 11 minutes 21.25 seconds + or - 0.5 second and the semimajor axis is 3.1054 Jupiter radii. The observed profile is roughly circular with a diameter of 80 kilometers. An albedo of approximately 0.05 is reported, which is similar to Amalthea's. The geometry of the observational situation is illustrated.
[Post-vaccination granuloma due to aluminium hydroxide].
Bordet, A L; Michenet, P; Cohen, C; Arbion, F; Ekindi, N; Bonneau, C; Kerdraon, R; Coville, M
Post-vaccination granulomas a well-known reaction due to aluminium adsorbed vaccines. We report three cases of children who developed subcutaneous nodules at the site of a previous injection of Tetracoq*vaccine (tetanus, diphtheria, Bordetella pertussis, poliovirus). Histologically, the lesions were characterized by a necrotizing granulomatous reaction with eosinophilic crystalline material. This material stained positively with the solochrome cyanine stain and was pink-purple. This aluminium stain enabled diagnosis of post-immunization injection-site reaction due to aluminium. PMID:11373585
A previously unreported locality record for the Gila monster (Heloderma suspectum)
Lovich, Jeff; Haxel, Gordon
Although the Gila Monster (Heloderma suspectum) is widely distributed throughout the Sonoran and portions of the Mojave Deserts of the southwestern United States and northwestern Mexico, details of its distribution in California are imperfectly known, due to the apparent rarity of the species in that state. In their review of Gila Monster records for California, Lovich and Beaman (2007) documented only 26 credible sightings during a period of 153 years. In May 2009 another sighting in California was documented by Ruppert (2010a, b) who photographed a specimen in the Providence Mountains, an area known for previous Gila Monster sightings (Lovich and Beaman 2007). In this paper we report the 28th credible record of a Gila Monster in California.
Persistent coagulopathy during Escherichia coli sepsis in a previously healthy infant revealed undiagnosed tyrosinaemia type 1
Georgouli, H; Schulpis, K H; Michelakaki, H; Kaltsa, M; Sdogou, T; Kossiva, L
Hereditary tyrosinaemia type 1 (HT1) is caused by an enzymatic defect in tyrosine metabolism. It is an autosomal recessive disorder and affects both sexes equally. In young infants HT1 can present as severe liver involvement and in older infants as liver failure and renal tubular dysfunction together with growth failure and rickets. The authors report the case of a 5-month-old, previously healthy, male infant who presented with Escherichia coli sepsis and severe coagulopathy due to liver dysfunction. Despite the early diagnosis of HT1 and treatment with 2-(2-nitro-4-trifluoromethylbenzoyl)-1, 3-cyclohexanedione (NTBC), the patient died from severe coagulopathy and multi-organ failure. PMID:22802474
Persistent coagulopathy during Escherichia coli sepsis in a previously healthy infant revealed undiagnosed tyrosinaemia type 1.
Georgouli, H; Schulpis, K H; Michelakaki, H; Kaltsa, M; Sdogou, T; Kossiva, L
Hereditary tyrosinaemia type 1 (HT1) is caused by an enzymatic defect in tyrosine metabolism. It is an autosomal recessive disorder and affects both sexes equally. In young infants HT1 can present as severe liver involvement and in older infants as liver failure and renal tubular dysfunction together with growth failure and rickets. The authors report the case of a 5-month-old, previously healthy, male infant who presented with Escherichia coli sepsis and severe coagulopathy due to liver dysfunction. Despite the early diagnosis of HT1 and treatment with 2-(2-nitro-4-trifluoromethylbenzoyl)-1, 3-cyclohexanedione (NTBC), the patient died from severe coagulopathy and multi-organ failure. PMID:22802474
Effectiveness of fly-ash replacement in the reduction of damage due to alkali-aggregate reaction in concrete. Research report
J. Farbiarz; R. L. Carrasquillo
The concrete industry is faced with the urgent need of improving its knowledge about the mechanism by which fly ash helps in the reduction of damage due to alkali-aggregate reaction in concrete to acceptable levels. The main objective of the research was to identify the most-relevant components of fly ash, cement, and concrete aggregates affecting the alkali-aggregate reaction, and to
Event sequence variability in healthy swallowing: building on previous findings.
Molfenter, Sonja M; Leigh, Chelsea; Steele, Catriona M
This study builds on previous work by Kendall, Leonard, and McKenzie, which investigated event sequence variability for 12 paired events during swallowing by healthy volunteers. They identified four event pairs that always occurred in a stereotyped order and a most common occurring overall order of events during swallowing. In the current study, we investigated overall event sequencing and the same four paired events in a sample of swallows by healthy young (under 45Āyears old) volunteers. Data were collected during a 16-swallow lateral videofluoroscopy protocol, which included manipulations of bolus volume, barium density, bolus viscosity, and swallow cueing. Our results agreed with previous findings that variable event sequencing is found in healthy swallowing, and, in regard to obligatory sequencing of two paired events, movement of the arytenoids toward the base of the epiglottis begins prior to upper esophageal sphincter (UES) opening and maximum hyolaryngeal approximation occurs after UES opening. However, our data failed to replicate the previous findings that there is obligatory sequencing of maximum pharyngeal constriction after maximal UES distension and the UES opens before bolus arrival at the UES. The most common observed overall event sequence reported by Kendall et al. was observed in only 4/293 swallows in our dataset. Manipulations of bolus volume, bolus viscosity, barium concentration, swallow cueing, and swallow repetitions could not completely account for the differences observed between the two studies. PMID:24390702
Nursing Workforce: Emerging Nurse Shortages Due to Multiple Factors. Report to the Chairman, Subcommittee on Health, Committee on Ways and Means, House of Representatives.
ERIC Educational Resources Information Center
Heinrich, Janet
Current evidence suggests emerging shortages of nurses available or willing to fill some vacant positions in hospitals, nursing homes, and home care. Total employment of registered nurses (RNs) per capita and the national unemployment rate for RNs have declined, and providers from around the country report growing difficulty recruiting andģ
Are Student Ratings of Communication Instructors Due to "Easy" Grading Practices? An Analysis of Teacher Credibility and Student-Reported Performance Levels.
ERIC Educational Resources Information Center
Beatty, Michael J.; Zahn, Christopher J.
Investigates the empirical relationships between student ratings of teachers and student-reported performance. Finds that students discriminate between sociability and qualification-related aspects of teacher performance and that student ratings were not the product of "easy" grading practices. (SR)
Low back pain due to spinal chronic subdural hematoma mimicking intradural tumor in the lumbar area: a case report and literature review
Serdar Kahraman; Sait ?irin; Hakan Kayali; Ilker Solmaz; Altay Bed³k
Although magnetic resonance imaging has dramatically enhanced the ability to diagnose spinal mass lesions, some lesions remain difficult to diagnose. We report a spinal chronic subdural hematoma that comprised the cauda equina ventrally in the lumbar area in a 51-year-old man who was under anticoagulant therapy. Low back pain was the only symptom of the patient after sports activity. Surgical
Honeybee colony collapse due to Nosema ceranae in professional apiaries.
Higes, Mariano; MartĒn-Hernßndez, Raquel; Garrido-Bail¾n, Encarna; Gonzßlez-Porto, Amelia V; GarcĒa-Palencia, Pilar; Meana, Aranzazu; Del Nozal, MarĒa J; Mayo, R; Bernal, Josķ L
Honeybee colony collapse is a sanitary and ecological worldwide problem. The features of this syndrome are an unexplained disappearance of adult bees, a lack of brood attention, reduced colony strength, and heavy winter mortality without any previous evident pathological disturbances. To date there has not been a consensus about its origins. This report describes the clinical features of two professional bee-keepers affecting by this syndrome. Anamnesis, clinical examination and analyses support that the depopulation in both cases was due to the infection by Nosema ceranae (Microsporidia), an emerging pathogen of Apis mellifera. No other significant pathogens or pesticides (neonicotinoids) were detected and the bees had not been foraging in corn or sunflower crops. The treatment with fumagillin avoided the loss of surviving weak colonies. This is the first case report of honeybee colony collapse due to N. ceranae in professional apiaries in field conditions reported worldwide. PMID:23765741
Bilateral muscular tinnitus due to myoclonus of extrinsic auricular muscles.
Lee, Kijeong; Chang, Jiwon; Park, Sangheon; Im, Gi Jung; Choi, Hyung Joon; Kim, Jin Hwan; Kim, Hyung-Jong
The muscular tinnitus due to an extrinsic auricular myoclonus is an extremely rare disorder which demonstrates a semirhythmic involuntary movement of the ear. We report a 33-year-old man with clicking tinnitus caused by focal myoclonic jerks of bilateral posterior auricularis muscle and bilateral temporalis muscle. This muscular tinnitus persisted except for when he was sleeping or breath holding. His symptom responded poorly to medical therapy but was controlled by botulinum toxin type A injection under electromyography monitoring with favorable outcome. Previous reports of this condition and possible therapeutic approaches are discussed. PMID:25466808
Wildlife Loss Estimates and Summary of Previous Mitigation Related to Hydroelectric Projects in Montana, Volume Three, Hungry Horse Project.
Casey, Daniel
This assessment addresses the impacts to the wildlife populations and wildlife habitats due to the Hungry Horse Dam project on the South Fork of the Flathead River and previous mitigation of theses losses. In order to develop and focus mitigation efforts, it was first necessary to estimate wildlife and wildlife hatitat losses attributable to the construction and operation of the project. The purpose of this report was to document the best available information concerning the degree of impacts to target wildlife species. Indirect benefits to wildlife species not listed will be identified during the development of alternative mitigation measures. Wildlife species incurring positive impacts attributable to the project were identified.
Hospitalization Due to Co-Morbid Conditions is the Main Cost Driver Among Subjects With COPD-A Report From the Population-Based OLIN COPD Study.
Jansson, Sven-Arne; Backman, Helena; R÷nmark, Eva; Lundbõck, Bo; Lindberg, Anne
Abstract Background: Co-morbidities are common in COPD; however, there is a lack of population-based studies evaluating the health economic impact of co-morbid diseases for subjects with COPD. The main objective of this study was to estimate annual direct health-care costs, divided into costs due to non-respiratory and respiratory conditions, comparing subjects with and without COPD. Methods: Subjects with and without COPD derived from population-based cohorts in northern Sweden have been invited to annual examinations involving spirometry and structured interviews since 2005. This paper is based on data from 1472 subjects examined in 2006. COPD classification was based on spirometry. Results: Mean annual costs for both respiratory and non-respiratory conditions were significantly higher for subjects with COPD than non-COPD subjects, in total USD 2139Āvs. USD 1276 (p = 0.026), and COPD remained significantly associated with higher costs also after adjustment for common confounders as age, smoking habits, BMI and sex. The mean total cost increased with COPD disease severity and was higher for all severity stages (GOLD) than for non-COPD subjects. Hospitalization due to non-respiratory diseases was the main cost driver in COPD, after adjustment for common confounders amounting to about 46% (unadjusted 62%) of the total COPD-costs. Conclusions: Costs were higher for COPD than non-COPD. In COPD, costs for co-morbid conditions were higher than those for respiratory conditions, and hospitalization due to co-morbid conditions was the main cost driver also when adjusted for common confounders. PMID:25415366
Ground subsidence due to mining operations. October 1976-November 1989 (Citations from the COMPENDEX data base). Report for October 1976-November 1989
Not Available
This bibliography contains citations concerning ground subsidence associated with mining operations. Mine subsidence is discussed with reference to mathematical modeling, forecasting extent of cavitation, and rock mechanics and mechanisms of stress relaxation. Damage to above- and below-ground structures as well as agricultural areas, and mining techniques designed to prevent or reduce subsidence are included. Monitoring of subsidence and detection of cavitation for surface, underground, and ocean-floor mining areas are discussed and examples are analyzed. Subsidence due to aquifer water removal is referenced in a related published bibliography. (Contains 213 citations fully indexed and including a title list.)
Internal jugular vein thrombosis presenting as a painful neck mass due to a spontaneous dislocated subclavian port catheter as long-term complication: a case report.
Binneb÷sel, Marcel; Grommes, Jochen; Junge, Karsten; G÷bner, Sonja; Schumpelick, Volker; Truong, Son
Central venous access devices are extensively used for long-term chemotherapy and parenteral nutrition. However, there are some possible immediate, early, and late complications related to the implantation technique, care, and maintenance. We present the uncommon occurrence of a thrombosis of the internal jugular vein due to a spontaneous migration of a Port-A-Cath catheter into the ipsilateral internal jugular vein as a delayed complication of a central venous access catheter implanted for chemotherapy delivery. A review of the literature is given, and the factors responsible for this unusual complication will be discussed. PMID:19830037
A Case of Infant Botulism due to Neurotoxigenic Clostridium butyricum Type E Associated with Clostridium difficile Colitis
L. Fenicia; L. Da Dalt; F. Anniballi; G. Franciosa; S. Zanconato; P. Aureli
. ĀĀReported here is the sixth case of intestinal toxemia botulism caused by Clostridium butyricum type E in Italy since 1984. In this case, the patient was concomitantly affected with colitis due to Clostridium difficile toxin. A review of previously reported cases revealed that some of these patients may also have had intestinal toxemia botulism\\u000a associated with Clostridium difficile colitis,
[Congenital adrenal hyperplasia due to lack of 17?-hydroxylase: a report of a new mutation in the gene CYP17A1].
Perales MartĒnez, J I; Pina Marquķs, B; de Arriba Mu±oz, A; Mayayo Dehesa, E; Labarta Aizp·n, J I; Loidi Fernßndez, L
P450c17 enzyme catalyses two different reactions: the 17?-hydroxylation of progesterone and pregnenolone, and segmenting the carbon 17-20 binding from the 17,20lyase producing adrenal androgens. This enzyme is coded by the CYP17A1 gene. The case is presented of a 14 year old patient with delayed pubertal development and a high blood pressure for height and age. 46,XX karyotype. Hormonal studies highlighted hypergonadotropic hypogonadism, adrenal insufficiency and mineralocorticoid excess. Subsequent genetic studies showed a homozygous mutation in the CYP17A1 gene (c.753+G>A), not previously described, which is responsible for the pathophysiology of 17?-hydroxylase deficiency. This entity is a rare form of congenital adrenal hyperplasia. The disease often goes unnoticed until adolescence or early adult life, and should be suspected in 46,XY individuals with ambiguous genitalia or 46,XX with delayed puberty associated with hypertension and/or hypokalaemia. PMID:24593890
Chronic nonspherocytic hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency: report of two families with novel mutations causing G6PD Bangkok and G6PD Bangkok Noi
Voravarn S. Tanphaichitr; Akira Hirono; Parichat Pung-amritt; Ajjima Treesucon; Wanchai Wanachiwanawin
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common hereditary enzymopathies worldwide. Mostly G6PD\\u000a deficient cases are asymptomatic though they may have the risk of neonatal jaundice (NNJ) and acute intravascular hemolysis\\u000a during oxidative stress. Chronic nonspherocytic hemolytic anemia (CNSHA) due to G6PD deficiency is rare. In Thailand, one\\u000a case was reported 40Āyears ago and by biochemical study this
Hemorrhagic shock occurring due to a concealed hematoma after insertion of a subclavian venous catheter in a patient undergoing anticoagulation therapy: a case report
Hwang, Boo-Young; Kim, Won-Sung; Cho, Ah-Reum; Cho, Mi-Jung; Lee, Chung-Won
A 74-year-old man who had been receiving warfarin for atrial fibrillation, underwent emergency thrombectomy. A central venous catheter (CVC) was inserted via the left subclavian vein, and heparin was administered to prevent preoperative and postoperative thrombotic events. After an uneventful thrombectomy, the patient was transferred to the intensive care unit (ICU). On the second postoperative day, the patient developed syncope and his blood pressure and oxygen saturation decreased. A computed tomography (CT) revealed a huge hematoma under the pectoralis major muscle. The patient was then treated with continuous renal replacement therapy and mechanical ventilation for multiorgan dysfunction syndrome, which developed due to hemorrhagic shock in the ICU. These findings suggest that when a CVC is inserted in patients requiring anticoagulant therapy, the possible risk of excessive bleeding must be carefully considered. Further, choosing a proper insertion site and performing an ultrasound-guided aspiration may be helpful in preventing these complications. PMID:25473468
Total Splenectomy due to an Unexpected ōComplicationö after Successful Extended Laparoscopic Partial Decapsulation of a Giant Epidermoid Splenic Cyst: A Case Report
Pitiakoudis, Michail; Zezos, Petros; Oikonomou, Anastasia; Laftsidis, Prodromos; Kouklakis, Georgios; Simopoulos, Constantinos
Splenic cysts are rare entities and are classified as true cysts or pseudocysts based on the presence of an epithelial lining. Congenital nonparasitic true cysts can be epidermoid, dermoid, or endodermoid, present at a young age, and are commonly located in the upper pole of the spleen. Surgical treatment is recommended for symptomatic, large (more than 5?cm), or complicated cysts. Depending on cyst number, location, relation to hilus, and the major splenic vessels, the surgical options include aspiration, marsupialization, cystectomy, partial cystectomy (decapsulation), and partial or complete splenectomy. Laparoscopic techniques have now become the standard approach for many conditions, including the splenic cysts, with emphasis on the spleen-preserving minimally invasive operations. We present the successful extended partial laparoscopic decapsulation of a giant epidermoid splenic cyst in a young female patient that, although asymptomatic, was unfortunately followed by complete splenectomy five days later due to a misinterpreted abdominal CT suggesting splenic postoperative ischemia. PMID:21687593
Core Liquid Level Depression due to Manometric Effect during PWR Small Break LOCA
Masahiro OSAKABE; Taisuke YONOMOTO; Yutaka KUKITA; Yasuo KOIZUMI; Kanji TASAKA
In the previous study, it is reported that the core collapsed liquid level was depressed nearly to the core bottom and the dryout of the core was observed in the early stage of the PWR cold leg small break loss-of-coolant accident (LOCA) experiment, The manometric effect due to the liquid seal formation in the loop seal and the difference of
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Massihullah Hamidi; Wayne C Drevets; Joseph L Price
BackgroundA previous study reported reductions in glial density and glia\\/neuron ratio in the amygdala of individuals with major depressive disorder (MDD), without a change in neuronal density. It is not known, however, whether this glial loss is due to astrocytes, oligodendrocytes, or microglia.
Strangulation of the umbilical cord due to combined amniotic band and true knot.
Elchalal, U; Ashkenazy, M; Weissman, A; Rosenman, D; Blickstein, I
A case of fetal death due to an amniotic band and an umbilical cord true knot is presented. To the best of our knowledge the simultaneous occurrence of true knot of cord and amniotic band has never been previously reported and may shed light on the possible time of true knot formation in this case. PMID:1348990
A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review
Lee, Hae-Lim; Cho, Sung-Yeon; Ko, Yumi; Hyun, Ji In; Kim, Bo Kyoung; Seo, Jae Hyun; Lee, Jung Woo; Lee, Seok
Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation. PMID:25298910
Malignant tumor-like gastric lesion due to Candida albicans in a diabetic patient treated with cyclosporin: a case report and review of the literature.
Mansueto, Pasquale; Pisciotta, Giuseppe; Tomasello, Giovanni; Cabibi, Daniela; Seidita, Aurelio; D'Alcamo, Alberto; Patti, Angelo Maria; Sprini, Delia; Carroccio, Antonio; Rini, Giovam Battista; Fede, Gaetana Di
The gastrointestinal tract of healthy individuals is colonized by hundreds of saprophytes and mycetes, especially the Candida species, are habitual ones. Under certain conditions, the fungal flora may overgrow, resulting in lesions of the digestive mucosa which, rarely, can have a local diffusion and/or spread to the lympho-hematogenous system. Mycotic infections of the stomach can sometimes look like benign gastric ulcers. Here, we present the case report of a woman, aged 64, who presented with type II diabetes mellitus and psoriasis, on chronic treatment with cyclosporin A and with endoscopic evidence of an ulcerated, vegetating gastric lesion secondary to Candida albicans infection. Although strongly suggestive of malignancy, it completely healed after cyclosporin withdrawal and the administration of oral antifungal drugs. PMID:21904834
Analysis of reservoir heterogeneities due to shallowing-upward cycles in carbonate rocks of the Pennsylvanian Wahoo Limestone of Northeastern Alaska. Annual report, September 1989--September 1990
Watts, K.F.
This report presents the preliminary results of research accomplished by a team of specialists in carbonate petrology, biostratigraphy, and diagenesis during the 1989--1990 fiscal year. It includes a summary of some of the petrographic data which has been entered into a computerized database; a discussion of biostratigraphic data, particularly conodont biofacies analyses; an overview of diagenetic studies; and a section of the regional geological framework studies. The database is allowing us to test which parameters, such as ooids, can be used to recognize and understand the carbonate petrology of the shallowing-upward cycles. The cycles have been interpreted in terms of depositional environments and sea-level fluctuations and used to develop detailed facies models.
Did Bechterew describe the disease which is named after him? A question raised due to the centennial of his primary report.
Leden, I
From paleopathological studies of egyptian mummies it is known that pelvospondylitis existed in ancient times. In spite of that a disease entity has not been clearly defined until recent years. The discovery of the rheumatoid factor, 1940 by Waaler and 1948 by Rose, allowed differentiation from RA. The first criteria for pelvospondylitis were proposed at a symposium in Rome 1961. Another important step in the history of pelvospondylitis occurred in 1973 when the connection to the HLA-B27 was discovered. Initial clinical descriptions appeared in the last decade of the 18th century. One of the contributors was the Russian Wladimir Bechterew (Fig. 1) whose name thereafter has been linked to the disease. Since it is the centennial of Bechterew's original report it seems appropriate to review that publication. PMID:8108667
Reconsolidation may incorporate state-dependency into previously consolidated memories.
Sierra, Rodrigo O; Cassini, Lindsey F; Santana, Fabiana; Crestani, Ana P; Duran, Johanna M; Haubrich, Josuķ; de Oliveira Alvares, Lucas; Quillfeldt, Jorge A
Some memories enter into a labile state after retrieval, requiring reconsolidation in order to persist. One functional role of memory reconsolidation is the updating of existing memories. There are reports suggesting that reconsolidation can be modulated by a particular endogenous process taking place concomitantly to its natural course, such as water or sleep deprivation. Here, we investigated whether an endogenous process activated during a natural/physiological experience, or a pharmacological intervention, can also contribute to memory content updating. Using the contextual fear conditioning paradigm in rats, we found that the endogenous content of an aversive memory can be updated during its reconsolidation incorporating consequences of natural events such as water deprivation, transforming a previously stored memory into a state-dependent one. This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation. Systemic morphine injection was also able to turn a previously acquired experience into a state-dependent memory, reproducing the very same effects obtained by water deprivation or local angiotensin II infusion, and suggesting that other state-dependent-inducing protocols would also be able to contribute to memory updating. These findings trigger new insights about the influence of ordinary daily life events upon memory in its continuing reconstruction, adding the realm of reconsolidation to the classical view of endogenous modulation of consolidation. PMID:23782508
Assessment of predictive models for the failure of titanium and ferrous alloys due to hydrogen effects. Report for the period of June 16 to September 15, 1981
Archbold, T.F.; Bower, R.B.; Polonis, D.H.
The 1977 version of the Simpson-Puls-Dutton model appears to be the most amenable with respect to utilizing known or readily estimated quantities. The Pardee-Paton model requires extensive calculations involving estimated quantities. Recent observations by Koike and Suzuki on vanadium support the general assumption that crack growth in hydride forming metals is determined by the rate of hydride formation, and their hydrogen atmosphere-displacive transformation model is of potential interest in explaining hydrogen embrittlement in ferrous alloys as well as hydride formers. The discontinuous nature of cracking due to hydrogen embrittlement appears to depend very strongly on localized stress intensities, thereby pointing to the role of microstructure in influencing crack initiation, fracture mode and crack path. The initiation of hydrogen induced failures over relatively short periods of time can be characterized with fair reliability using measurements of the threshold stress intensity. The experimental conditions for determining K/sub Th/ and ..delta..K/sub Th/ are designed to ensure plane strain conditions in most cases. Plane strain test conditions may be viewed as a conservative basis for predicting delayed failure. The physical configuration of nuclear waste canisters may involve elastic/plastic conditions rather than a state of plane strain, especially with thin-walled vessels. Under these conditions, alternative predictive tests may be considered, including COD and R-curve methods. The double cantilever beam technique employed by Boyer and Spurr on titanium alloys offers advantages for examining hydrogen induced delayed failure over long periods of time. 88 references. (DLC)
Complete Recovery With the Chain of Survival After a Prolonged (120 Minutes) Out-of-Hospital Cardiac Arrest Due to Brugada Syndrome: A Case Report.
He, Fei; Xu, Peng; Wei, Zhong-Hai; Zhang, Jun; Wang, Jun
Out-of-hospital cardiac arrest (OHCA) is a crucial public health problem. To improve outcomes of patients after cardiac arrest, the American Heart Association promotes the concept of the chain of survival.We report a case of a 19-year-old man with no markedly past medical history who suffered from OHCA, and he was resuscitated with cardiopulmonary resuscitation, without interruption, during the rescue process for 120 minutes until return of spontaneous circulation (ROSC). Electrocardiogram on admission showed right bundle branch block and ST segment elevation in leads V1-V2, and the patient's uncle had experienced the same event and had received implantable cardioverter defibrillator (ICD) treatment. Therefore, the patient was diagnosed with Brugada syndrome. Postcardiac arrest care was performed after ROSC, including mild therapeutic hypothermia, hemodynamic monitoring and management, and ICD implantation, and then the patient completely recovered without any noticeable neurological or intellectual deficits in the follow-up examinations.Our case demonstrates that even after an OHCA with prolonged time (120 minutes) until ROSC, survival with a favorable neurological outcome is possible, provided implementation of an extremely effective rescue chain. PMID:26166103
A case report of two brothers with ATR-X syndrome due to low maternal frequency of somatic mosaicism for an intragenic deletion in the ATRX.
Shimbo, Hiroko; Ninomiya, Shinsuke; Kurosawa, Kenji; Wada, Takahito
In clinical practice, it is important to diagnose the carrier state of female patients with X-linked diseases for genetic counseling to calculate the recurrent risk of offspring. Because some X-linked diseases show high rates of gonadal mosaicism, this diagnosis is sometimes difficult, when there are few offspring in a family and no mutation is detected in the maternal genomic DNA. Here, we report two male siblings with ATR-X syndrome carrying an intragenic deletion of 78.6?kb involving exons 2-5 out of the 35 exons in the ATRX, as revealed by PCR amplification of these exons. The mother was expected to be an obligate carrier, but we could not confirm her as a mutation carrier by quantitative PCR (qPCR) for the exons. However, we identified the breakpoint of ATRX, and qPCR with breakpoint-specific primers revealed gonosomal mosaicism, with a relative frequency of the mutation of <1% in genomic DNA of her peripheral blood. For these obligate carriers of X-linked disease, we should aggressively investigate the maternal genomic status, not only because her genetic condition is important for estimating the recurrent risk of her offspring but also because a diagnosis of her gonosomal mosaicism can render negligible the possibility that her female siblings are carriers. We should reconfirm that a female who has a risk of being a carrier has a gonosomal or somatic mutation, even if she is an obligate carrier or apparently harbors a mutation. PMID:24898829
[Unstable hypertension due to renal artery compression by the developed diaphragm in a 17-year-old athlete: a case report].
Maeda, Sayako; Yamamoto, Shinya; Makiishi, Tetsuya
A 17-year-old high school boy was admitted to our hospital because of hypertension. Doppler ultrasound of the renal arteries and 3D-CT angiography showed a stenosis of the right renal artery, which was pushed against the aorta by the right crus of the diaphragm. He underwent aortography and selective renal arteriography. His right renal artery originated from the aorta at a higher level than the left renal artery, between the celiac artery and the superior mesenteric artery. Renal arteriography confirmed a 50% reduction in diameter (stenosis) of the proximal right renal artery entrapped by the right diaphragmatic crus. This pathology, unlike common renal artery stenosis, sometimes requires surgical decompression or an aortorenal bypass graft, because renal angioplasty with stenting is reported to be at risk of complication by a fracture of the stent. However, the patient rejected surgical decompression for fear of deterioration of his athletic ability. Therefore we decided to follow up his blood pressure and renal size by ultrasound every six months. Renovascular hypertension caused by diaphragmatic entrapment is a very rare disease. The diagnosis may be overlooked easily at angiography if optimal views are not obtained. It is important to display images of the renal arteries, the celiac artery and the superior mesenteric artery in both inspiration and expiration. PMID:21516709
Previous Mental Health Service Utilization and Change in Clients' Depressive Symptoms
ERIC Educational Resources Information Center
Boswell, James F.; McAleavey, Andrew A.; Castonguay, Louis G.; Hayes, Jeffrey A.; Locke, Benjamin D.
Although a potentially important factor in case conceptualization and treatment planning, the impact of previous treatment on subsequent counseling response has received little empirical attention. Using archival data, this study aimed to (a) report the prevalence of previous treatment utilization in a counseling population, (b) examine potentialģ
Contributions of Attentional Style and Previous Experience to 4-Month-Old Infants' Categorization
ERIC Educational Resources Information Center
Kovack-Lesh, Kristine A.; Oakes, Lisa M.; McMurray, Bob
We examined how infants' categorization is jointly influenced by previous experience and how much they shift their gaze back and forth between stimuli. Extending previous findings reported by K. A. Kovack-Lesh, J. S. Horst, and L. M. Oakes (2008), we found that 4-month-old infants' (N = 122) learning of the exclusive category of "cats" was relatedģ
Small Bowel Perforation due to Gossypiboma Caused Acute Abdomen.
Colak, Tahsin; Olmez, Tolga; Turkmenoglu, Ozgur; Dag, Ahmet
Gossypiboma, an infrequent surgical complication, is a mass lesion due to a retained surgical sponge surrounded by foreign body reaction. In this case report, we describe gossypiboma in the abdominal cavity which was detected 14 months after the hysterectomy due to acute abdominal pain. Gossypiboma was diagnosed by computed tomography (CT). The CT findings were a rounded mass with a dense central part and an enhancing wall. In explorative laparotomy, small bowel loops were seen to be perforated due to inflammation of long standing gossypiboma. Jejunal resection with end-to-end anastomosis was performed. The patient was discharged whithout complication. This case was presented to point to retained foreign body (RFB) complications and we believed that the possibility of a retained foreign body should be considered in the differential diagnosis of who had previous surgery and complained of pain, infection, or palpable mass. PMID:24288645
Small Bowel Perforation due to Gossypiboma Caused Acute Abdomen
Turkmenoglu, Ozgur; Dag, Ahmet
Gossypiboma, an infrequent surgical complication, is a mass lesion due to a retained surgical sponge surrounded by foreign body reaction. In this case report, we describe gossypiboma in the abdominal cavity which was detected 14 months after the hysterectomy due to acute abdominal pain. Gossypiboma was diagnosed by computed tomography (CT). The CT findings were a rounded mass with a dense central part and an enhancing wall. In explorative laparotomy, small bowel loops were seen to be perforated due to inflammation of long standing gossypiboma. Jejunal resection with end-to-end anastomosis was performed. The patient was discharged whithout complication. This case was presented to point to retained foreign body (RFB) complications and we believed that the possibility of a retained foreign body should be considered in the differential diagnosis of who had previous surgery and complained of pain, infection, or palpable mass. PMID:24288645
New Approaches for Isolation of Previously Uncultivated Oral Bacteria
Sizova, M. V.; Hohmann, T.; Hazen, A.; Paster, B. J.; Halem, S. R.; Murphy, C. M.; Panikov, N. S.
A significant number of microorganisms from the human oral cavity remain uncultivated. This is a major impediment to the study of human health since some of the uncultivated species may be involved in a variety of systemic diseases. We used a range of innovations previously developed to cultivate microorganisms from the human oral cavity, focusing on anaerobic species. These innovations include (i) in vivo cultivation to specifically enrich for species actively growing in the oral cavity (the ōminitrapö method), (ii) single-cell long-term cultivation to minimize the effect of fast-growing microorganisms, and (iii) modifications of conventional enrichment techniques, using media that did not contain sugar, including glucose. To enable cultivation of obligate anaerobes, we maintained strict anaerobic conditions in most of our cultivation experiments. We report that, on a per cell basis, the most successful recovery was achieved using minitrap enrichment (11%), followed by single-cell cultivation (3%) and conventional plating (1%). Taxonomically, the richest collection was obtained using the single-cell cultivation method, followed by minitrap and conventional enrichment, comprising representatives of 13, 9, and 4 genera, respectively. Interestingly, no single species was isolated by all three methods, indicating method complementarity. An important result is the isolation and maintenance in pure culture of 10 strains previously only known by their molecular signatures, as well as representatives of what are likely to be three new microbial genera. We conclude that the ensemble of new methods we introduced will likely help close the gap between cultivated and uncultivated species from the human oral cavity. PMID:22057871
NC: No Change from Previous Reporting Period NI: No Information about Earlier Reporting Period
State as Leading Public Land Grant Benchmark Average 1. US News Academic Reputation Score (2003) 3.7 4, Hispanic, and Native American Tenured/Tenure Track Faculty (2003) 5.5 6.7 NC 3. % of Minority Staff (2003) 19.7 22.8 NC 4. % of African-American & Hispanic Students (2003) 10 11.7 NC 5. African
27 CFR 26.55 - Previously approved formulas.
Code of Federal Regulations, 2010 CFR
...2010-04-01 false Previously approved formulas. 26.55 Section 26.55 Alcohol...PUERTO RICO AND THE VIRGIN ISLANDS Formulas for Products From Puerto Rico ¦ 26.55 Previously approved formulas. Any formula approved on...
27 CFR 26.55 - Previously approved formulas.
Code of Federal Regulations, 2011 CFR
...2011-04-01 false Previously approved formulas. 26.55 Section 26.55 Alcohol...PUERTO RICO AND THE VIRGIN ISLANDS Formulas for Products From Puerto Rico ¦ 26.55 Previously approved formulas. Any formula approved on...
27 CFR 26.225 - Previously approved formulas.
Code of Federal Regulations, 2011 CFR
...2011-04-01 false Previously approved formulas. 26.225 Section 26.225...PUERTO RICO AND THE VIRGIN ISLANDS Formulas for Products From the Virgin Islands ¦ 26.225 Previously approved formulas. Any formula approved on...
27 CFR 26.225 - Previously approved formulas.
Code of Federal Regulations, 2010 CFR
...2010-04-01 false Previously approved formulas. 26.225 Section 26.225...PUERTO RICO AND THE VIRGIN ISLANDS Formulas for Products From the Virgin Islands ¦ 26.225 Previously approved formulas. Any formula approved on...
Interbirth interval and history of previous preeclampsia: a case¢control study among multiparous women
Background Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our study were to determine the association of long interbirth interval (IBI) and preeclampsia and to investigate the interactions between long IBI and other risk factors among multiparous women in Yerevan, Armenia. Methods We conducted a hospital-based case¢control study among 36 multiparous women with preeclampsia (cases) and 148 without preeclampsia (controls) during their last pregnancy, selected from the two largest maternity hospitals in Armenia. The data were collected through telephone-based structured interviews and analyzed using STATA software. The study applied univariate and multivariate logistic regression analyses. Results The study found a significant interaction between IBI and previous history of preeclampsia. Among women without a history of previous preeclampsia, the odds of having preeclampsia among women with long IBI (greater than or equal to five years) was 6.88 time higher compared to those with short IBI (CI: 1.75-27.05; p?=?0.006) after adjusting for confounders; among women with a history of previous preeclampsia the odds ratio was 0.60 (CI: 0.07-4.99; p?=?0.638). The final fitted model for preeclampsia among multiparous women who had planned their pregnancies included IBI, time to pregnancy, Body Mass Index, method of contraception and household monthly income. Conclusions Long IBI appeared to be a strong risk factor for preeclampsia development only among women without a history of previous preeclampsia. This finding may contribute to a new approach in understanding the etiology of preeclampsia and may be useful for developing further recommendations for this particular subgroup of women that are at higher risk for preeclampsia development in subsequent pregnancies. PMID:24373629
Colonic atresia associated with annular pancreas: An extremely rare and previously unreported association
Halder, Pankaj; Kumar, Rajarshi; Mukhopadhyay, Madhumita; Mandal, Kartik Chandra; Mukhopadhyay, Biswanath
Colonic atresia is the rarest entity among the all intestinal atresias and may be associated with anterior abdominal wall defect, small intestinal atresia, Hirschsprung's disease, and other anomalies. Here, we are reporting a case of colonic atresia associated with annular pancreas, which has not been reported previously to the best of our knowledge.
Effects of Weight Status and Barriers on Physical Activity Adoption Among Previously Inactive Women
Melissa A. Napolitano; George D. Papandonatos; Kelley E. Borradaile; Jessica A. Whiteley; Bess H. Marcus
This study examined self-reported physical activity (PA) barriers, and their effects on PA behavior change at 3 and 12 months among 280 previously inactive women enrolled in a PA promotion trial. Effect modification of baseline barriers by baseline weight status on PA behavior change was also examined. At baseline and month 12, obese women reported significantly greater PA barriers compared
Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia.
Eleftheriadis, Theodoros; Liakopoulos, Vassilios; Antoniadi, Georgia; Pissas, Georgios; Leivaditis, Konstantinos; Stefanidis, Ioannis
We describe a case of a patient with a functional kidney transplant who was admitted to our department with clinically evident central vein stenosis (CVS) 7 years after the removal of a central venous catheter (CVC) from the right internal jugular vein. The catheter was used as a hemodialysis access for a 2-month period. In the interval before his last admission, the patient suffered two episodes of deep vein thrombosis. Investigation revealed heterozygosity for factor V Leiden, the most common inherited thrombophilia encountered in 5% of Caucasians, and anticoagulation treatment was started. Magnetic resonance angiography showed stenosis just after the convergence of the right subclavian vein with the internal jugular vein to the innominate vein. Transluminal angioplasty restored venous patency and right upper arm edema resolved. Coexistence of CVS, accompanied by hemodynamic changes and endothelial dysfunction, with thrombophilia fulfill all the elements of the Virchow's triad. Therefore, the patient was at great risk for central vein thrombosis, from which he was possibly protected by the early administration of anticoagulant treatment. This case indicates that CVS can be asymptomatic for several years after CVC removal and also raises the question if thrombophilia workup and investigation for CVS may be beneficial in every patient with CVC placement in order to avoid any harmful outcomes. PMID:24350639
Previously Unknown Fault Shakes New Zealand's South Island
NASA Astrophysics Data System (ADS)
Quigley, M.; Villamor, P.; Furlong, K.; Beavan, J.; Van Dissen, R.; Litchfield, N.; Stahl, T.; Duffy, B.; Bilderback, E.; Noble, D.; Barrell, D.; Jongens, R.; Cox, S.
At 4:35 A.M. local time on 4 September (1635 UTC, 3 September), a previously unrecognized fault system ruptured in the Canterbury region of New ZealandÆs South Island, producing a moment magnitude (Mw) 7.1 earthquake that caused widespread damage throughout the area. In stark contrast to the 2010 Mw 7.0 Haiti earthquake, no deaths occurred and only two injuries were reported despite the epicenter's location about 40 kilometers west of Christchurch (population ś386,000). The Canterbury region now faces a rebuilding estimated to cost more than NZ$4 billion (US$2.95 billion). On the positive side, this earthquake has provided an opportunity to document the dynamics and effects of a major strike-slip fault rupture in the absence of death or serious injury. The low-relief and well-maintained agricultural landscape of the Canterbury Plains helped scientists characterize very subtle earthquake-related ground deformation at high resolution, helping to classify the earthquake's basic geological features [Quigley et al., 2010]. The prompt mobilization of collaborating scientific teams allowed for rapid data capture immediately after the earthquake, and new scientific programs directed at developing a greater understanding of this event are under way.
Anaphylaxis Due to Head Injury
Bruner, Heather C.; Bruner, David I.
Both anaphylaxis and head injury are often seen in the emergency department, but they are rarely seen in combination. We present a case of a 30-year-old woman who presented with anaphylaxis with urticaria and angioedema following a minor head injury. The patient responded well to intramuscular epinephrine without further complications or airway compromise. Prior case reports have reported angioedema from hereditary angioedema during dental procedures and maxillofacial surgery, but there have not been any cases of first-time angioedema or anaphylaxis due to head injury. PMID:25987924
Severe Left Atrioventricular Valve Regurgitation Due to Discontinuity between the Leaflets of the Aortic and Left Atrioventricular Valves in a Patient with Endocardial Cushion Defect: A Rare Case Report.
Nabati, Maryam; Habibi, Valiolla; Soleimani, Aria; Shokri, Mojtaba
Discontinuities between the leaflets of the aortic and left atrioventricular valves are uncommon congenital malformations. The anomaly may be discovered during surgery without preoperative diagnosis. It represents a spectrum of anomalies that result from interruption of the normal development of the endocardial cushions during the fetal life. We describe a rare case of Down syndrome with transient complete atrioventricular block and discontinuity between the leaflets of the aortic and left atrioventricular valves without intervening fibrous band, leading to separation and detachment between them. It caused severe eccentric jet of regurgitation originated from left ventricular outflow tract and base of anterior leaflet of left atrioventricular valve into the left atrium. He underwent cardiopulmonary bypass, and the defect between left atrioventricular valve and aortic annuli was sewn. Permanent epicardial pacing was inserted during cardiac surgery. To the best of our knowledge, such a case has not been previously reported in the literature. PMID:25483555
Determining root correspondence between previously and newly detected objects
Paglieroni, David W.; Beer, N Reginald
A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.
Geological Evidence that Mercury Contracted by More than Previously Recognized
NASA Astrophysics Data System (ADS)
Solomon, S. C.; Byrne, P. K.; Klimczak, C.; Sengor, A. M.; Watters, T. R.; Hauck, S. A.
Images of Mercury returned by the Mariner 10 spacecraft showed a hemisphere replete with landforms interpreted to be contractional tectonic structures. Most such structures were attributed to the horizontal shortening that accompanied planetary cooling and contraction; estimates of the amount of strain they accommodated corresponded to a decrease by 0.8-2 km in planetary radius. More recently, photogeological studies of flyby and orbital data from the MESSENGER spacecraft have suggested 1-3 km of radius decrease (for an assumed fault dip angle, ?, of 30░). In contrast, thermal history models of Mercury have consistently predicted ~5-10 km of radial contraction, substantially more than indicated by photogeology. In the most comprehensive synthesis yet of contractional tectonics on Mercury, we have used global photomosaics to make new estimates of planetary radius change due to global contraction. From the application of a scaling relationship between fault displacement and fault length derived from 216 representative structures for ?=35░-25░ to all mapped contractional landforms on Mercury, we find that the planet's radius has shortened by 4.7-7.1 km (5.7 km for ?=30░). Our survey includes smooth-plains-hosted wrinkle ridges, a portion of whose strain may be due to subsidence rather than global contraction. Even if all such structures are excluded, we calculate that Mercury's radius has decreased by 4.2-6.3 km (5.1 km for ?=30░). Whatever the extent to which wrinkle ridges accommodated some global contraction, Mercury experienced far more contraction than previously recognized. Our findings resolve a four-decades-old conflict: the planet's history of heat production and loss and the accumulated global contraction inferred from the record of surface deformation are now consistent. Our result provides an important new constraint for future thermal history models that address the bulk silicate abundances of heat-producing elements, the question of whether the mantle is currently convecting, and the history of cooling and present-day structure of Mercury's large metallic core, the source of the planet's internal magnetic field.
Unexpected causes of pulmonary hypertension in a previously healthy Thai rural man with right-sided heart failure
Angkananard, Teeranan; Chonmaitree, Piyanant; Petborom, Pichaya
Patient Male, 52 Final Diagnosis: Pulmonary hypertension Symptoms: Diarrhea Ģ dyspnea Ģ jaundice Medication: Ś Clinical Procedure: Ś Specialty: Endocrinology and Metabolic Objective: Unusual clinical course Background: Hyperthyroidism is one of the important causes of high-output failure and reversible pulmonary artery hypertension. Severe pulmonary artery hypertension is rarely found in associated with hyperthyroidism due to the small number of cases reported. We present an interesting case with multiple unexpected findings of the possible causes of severe pulmonary artery hypertension: hyperthyroidism, pulmonary embolism, and ostium secundum atrial septal defect. Case Report: We present the case of a previously healthy rural Thai man who progressively developed dyspnea on exertion, chronic diarrhea, and jaundice for the previous 3 months. Physical examination revealed right-sided predominate chronic heart failure with signs of pulmonary hypertension. The investigation demonstrated autoimmune hyperthyroidism, cholestatic jaundice, moderate tricuspid regurgitation, ostium secundum atrial septal defect, and severe pulmonary artery hypertension. After treatment with an anti-thyroid drug and closure of the ostium secundum atrial septal defect, his symptoms of jaundice and pulmonary artery pressure were completely resolved. Conclusions: Severe pulmonary artery hypertension may not solely be a result of hyperthyroidism. Further investigation for other causes is recommended. PMID:24808937
The Influence of Previous Mountain Pine Beetle (Dendroctonus
Moorcroft, Paul R.
The Influence of Previous Mountain Pine Beetle (Dendroctonus ponderosae) Activity on the 1988 (Dendroctonus ponderosae Hopkins) activity within Yellowstone National Park, Wyoming, for the 25-years period
DECOVALEX-THMC Task D: Long-Term Permeability/Porosity Changes inthe EDZ and Near Field due to THM and THC Processes in Volcanic andCrystaline-Bentonite Systems, Status Report October 2005
Birkholzer, J.; Rutqvist, J.; Sonnenthal, E.; Barr, D.
The DECOVALEX project is an international cooperativeproject initiated by SKI, the Swedish Nuclear Power Inspectorate, withparticipation of about 10 international organizations. The name DECOVALEXstands for DEvelopment of COupled models and their VALidation againstExperiments. The general goal of this project is to encouragemultidisciplinary interactive and cooperative research on modelingcoupled processes in geologic formations in support of the performanceassessment for underground storage of radioactive waste. Three multi-yearproject stages of DECOVALEX have been completed in the past decade,mainly focusing on coupled thermal-hydrological-mechanicalprocesses.Currently, a fourth three-year project stage of DECOVALEX isunder way, referred to as DECOVALEX-THMC. THMC stands for Thermal,Hydrological, Mechanical, and Chemical processes. The new project stageaims at expanding the traditional geomechanical scope of the previousDECOVALEX project stages by incorporating geochemical processes importantfor repository performance. The U.S. Department of Energy (DOE) leadsTask D of the new DECOVALEX phase, entitled "Long-termPermeability/Porosity Changes in the EDZ and Near Field due to THC andTHM Processes for Volcanic and Crystalline-Bentonite Systems." In itsleadership role for Task D, DOE coordinates and sets the direction forthe cooperative research activities of the international research teamsengaged in Task D.
No discrimination against previous mates in a sexually cannibalistic spider
NASA Astrophysics Data System (ADS)
Fromhage, Lutz; Schneider, Jutta M.
In several animal species, females discriminate against previous mates in subsequent mating decisions, increasing the potential for multiple paternity. In spiders, female choice may take the form of selective sexual cannibalism, which has been shown to bias paternity in favor of particular males. If cannibalistic attacks function to restrict a male's paternity, females may have little interest to remate with males having survived such an attack. We therefore studied the possibility of female discrimination against previous mates in sexually cannibalistic Argiope bruennichi, where females almost always attack their mate at the onset of copulation. We compared mating latency and copulation duration of males having experienced a previous copulation either with the same or with a different female, but found no evidence for discrimination against previous mates. However, males copulated significantly shorter when inserting into a used, compared to a previously unused, genital pore of the female.
The Role of Students' Previous Understandings in Reasoning Across Contexts
NASA Astrophysics Data System (ADS)
Casperson, Janet Marie
Learning is typically thought of as a change in a student's understanding within a single context. The term context is used here to describe a domain or subdomain of knowledge. Students' previous understandings of the context are known to play a considerable role in such learning. Another important kind of learning is reasoning across contexts. Through reasoning across contexts, students' understanding of one context influences understanding of another context. This dissertation investigated the role of students' previous understandings in this reasoning process. Psychology research has employed one type of experimental design to investigate reasoning across contexts. This has resulted in focus on a particular way of reasoning across contexts, called analogical transfer, in which participants' previous understandings play a minimal role. In contrast, this dissertation employed a case study design for the purpose of investigating the role of participants' previous understandings in reasoning across contexts. Participants' previous understandings of contexts were discovered to play a considerable role in their reasoning across contexts. Three categories of ways of reasoning across contexts in which students' previous understandings play a role were identified. In the first of these, a participant's new understanding of a context is a combination of ideas used previously to understand the same context and ideas used to understand another context. In the second, an idea from either the participant's previous understanding or from the participant's understanding of another context is modified to contribute to a new understanding. In the third, an idea from the participant's previous understanding is brought into different focus through comparison with a corresponding idea from another context. These three are termed combining, modifying, and refocusing interactions, respectively. Understanding of these different possible roles for students' previous understandings in reasoning across contexts can inform instruction in which a general concept is instructed through particular contexts. An example of such a general concept is the concept of equilibration considered here.
Visualization 4166 Projects : Project Proposals Due
Brooks, Stephen
Updates Due Apr 7th : Final Projects Due General notes: Evaluated for 45% of Final Grade. Projects it and a brief time-line. This will be worth 5% of your final grade. A two-page progress report. Screen captures of the system in operation are expected. This will be worth 5% of your final grade
Visualization 6406 Projects : Project Proposals Due
Brooks, Stephen
Updates Due Apr 7th : Final Projects Due General notes: Evaluated for 50% of Final Grade. Projects-line. This will be worth 5% of your final grade. A four-page progress report will be submitted partway through the term in operation are expected. This will be worth 5% of your final grade. At the end of the term, an eight
15 CFR 970.403 - Previous license and permit obligations.
Code of Federal Regulations, 2010 CFR
...OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Certification of Applications ¦ 970.403 Previous license...
14 CFR 47.33 - Aircraft not previously registered anywhere.
Code of Federal Regulations, 2010 CFR
...Space 1 2010-01-01 2010-01-01 false Aircraft not previously registered anywhere. 47.33 Section...AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Certificates of Aircraft...
14 CFR 47.33 - Aircraft not previously registered anywhere.
Code of Federal Regulations, 2011 CFR
...Space 1 2011-01-01 2011-01-01 false Aircraft not previously registered anywhere. 47.33 Section...AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Certificates of Aircraft...
14 CFR 47.33 - Aircraft not previously registered anywhere.
Code of Federal Regulations, 2013 CFR
...Space 1 2013-01-01 2013-01-01 false Aircraft not previously registered anywhere. 47.33 Section...AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Certificates of Aircraft...
14 CFR 47.33 - Aircraft not previously registered anywhere.
Code of Federal Regulations, 2014 CFR
...Space 1 2014-01-01 2014-01-01 false Aircraft not previously registered anywhere. 47.33 Section...AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Certificates of Aircraft...
14 CFR 47.33 - Aircraft not previously registered anywhere.
Code of Federal Regulations, 2012 CFR
...Space 1 2012-01-01 2012-01-01 false Aircraft not previously registered anywhere. 47.33 Section...AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION Certificates of Aircraft...
Baseball field looking North from same camera station as previous ...
Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey
Baseball field looking North from same camera station as previous view - New York State Soldiers & Sailors Home, Department of Veterans Affairs Medical Center, 76 Veterans Avenue, Bath, Steuben County, NY
A similar shot to the previous image, this photograph, looking ...
Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey
A similar shot to the previous image, this photograph, looking northwest, provides a closer image of the brick penthouse and other devices - Department of Energy, Mound Facility, Electronics Laboratory Building (E Building), One Mound Road, Miamisburg, Montgomery County, OH
10 CFR 71.19 - Previously approved package.
Code of Federal Regulations, 2010 CFR
...package, or a fissile material package, previously approved by NRC, provided...The modifications of a Type B package are not significant with respect...performance of the containment system, when the package is subjected to the tests...
10 CFR 71.19 - Previously approved package.
Code of Federal Regulations, 2011 CFR
...package, or a fissile material package, previously approved by NRC, provided...The modifications of a Type B package are not significant with respect...performance of the containment system, when the package is subjected to the tests...
10 CFR 71.19 - Previously approved package.
Code of Federal Regulations, 2013 CFR
...package, or a fissile material package, previously approved by NRC, provided...The modifications of a Type B package are not significant with respect...performance of the containment system, when the package is subjected to the tests...
10 CFR 71.19 - Previously approved package.
Code of Federal Regulations, 2012 CFR
...package, or a fissile material package, previously approved by NRC, provided...The modifications of a Type B package are not significant with respect...performance of the containment system, when the package is subjected to the tests...
10 CFR 71.19 - Previously approved package.
Code of Federal Regulations, 2014 CFR
...package, or a fissile material package, previously approved by NRC, provided...The modifications of a Type B package are not significant with respect...performance of the containment system, when the package is subjected to the tests...
29 CFR 779.2 - Previous and new coverage.
Code of Federal Regulations, 2013 CFR
...LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS THE FAIR LABOR STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES General Introductory ¦ 779.2 Previous and new coverage. Under the Act...
previously grouped with the flatworms. Several lines of
Buffalo, State University of New York
Magazine R985 previously grouped with the flatworms. Several lines of molecular evidence have of the intermediate taxa? Trends Genet. 15, 104Ł108. Aguinaldo, A.A., Turbeville, J.M., Linford, L.S., Rivera, M
Spinal troubles in sewage workers: epidemiological data and work disability due to low back pain
M. Friedrich; T. Cermak; I. Heiller
Objectives: To determine the prevalence of spinal troubles (i.e., neck, upper back and low back pain) in a population of sewage workers,\\u000a and to establish the effect of sociodemographic, work-related, physical, and psychosocial factors on the reported work disability\\u000a due to low back pain (LBP) during the previous 12?months. Methods: Data from 255?sewage workers were obtained by standardized questionnaire, structured
American Psychological Association Dues
Charles R. Kelley
This commentary criticizes the recent American Psychological Association dues increase. APA is obviously two things, a scientific organization and a psychologist's union. While the author wishes to support the national scientific organization in psychology, he is opposed to almost all of the activities of the psychologist's union, including certification, standardization of training for psychologists, \\
Psychotic disorder due to traumatic brain injury: analysis of case studies in the literature.
Fujii, Daryl; Fujii, Daniel C
The present study utilized methodology from a previous descriptive study that analyzed case studies of psychotic disorder due to traumatic brain injury (PD-TBI) reported in psychiatry and neurology journals. The purpose was to replicate findings from the PD-TBI literature and to elucidate a pattern of characteristics that would differentiate PD-TBI from schizophrenia. The findings supported both objectives. PD-TBI data were highly consistent with previous studies: PD-TBI differed from schizophrenia in showing more focal frontal and temporal abnormalities on neurological studies and a lower rate of negative symptoms. The authors discuss implications of these findings for conceptualizing psychosis as a neurobiological syndrome. PMID:23037642
Comparison of the efficacy and tolerability of solifenacin succinate with or without previous use of trospium chloride.
Metello, J; Nogueira, B; Torgal, M; Colańo, J; Vieira, A; Gonńalves, V; Retto, H
Overactive bladder syndrome (OBS) is described as urinary urgency with or without incontinence, usually with increased daytime frequency and nocturia in the absence of another identifiable pathological process. Nowadays and despite other alternative therapies, the mainstay of OBS is still the pharmacological approach, mainly with anti-muscarinic drugs. To compare the efficacy of a 30-day solifenacin succinate (5 mg OD) treatment with or without previous medication with trospium chloride, a prostective open, two-arm, parallel group study was conducted for 5 weeks in 40 patients with OBS. The primary endpoint was patient self-assessment of improvement after 30 days of medication. Secondary endpoints included the reduction of the daily number of voids and urgency or involuntary leakage episodes. Adverse reactions and therapeutic stoppage were also evaluated. To be included in the trospium chloride treatment group, patients were required to have been treated with such drug for 1 to 6 months before the present study. Evaluation and efficacy assessment were accomplished using a 3-day bladder diary and an urgency severity scale (USS). Safety assessment was done by recording all the patients' complaints after starting medication. A total of 40 patients were enrolled for this study, 19 without previous medication and 21 who had already tried trospium chloride. Two patients from the non-previous medication group were excluded. Globally, there was a statistically significant reduction for the USS (2.73-->1.73), the daily number of voids (9.5-->7.0), of urgency episodes (9.1-->4.0) and of involuntary leakage episodes (3.6-->1.0) over the 24 h. Six patients had no improvement, four from the previous trospium chloride group and two from the non-previous medication group. Three patients reported side effects, two cases of dry mouth and one case of constipation. One patient dropped out of the treatment due to an unspecified intolerance. Solifenacin succinate 5 mg seems to be effective concerning patients' self-assessment of improvement and decrease in the mean number of daily voids, urgency episodes and incontinence episodes. This was reported both in patients who have already been medicated with trospium chloride and those who have never taken any kind of medication. Regarding side effects, solifenacin is quite well-tolerated in both groups. PMID:17211528
Fatal bacteremic pneumonia caused by Aeromonas hydrophila in a previously healthy child
Hsiu-Tsun Kao; Yhu-Chering Huang; Tzou-Yien Lin
Aeromonas hydrophila sepsis and pneumonia are rare diseases in children that carry a high mortality rate. We report a case of fatal bacteremic pneumonia caused by A. hydrophila in a previously healthy 5-year-old child. The source of infection was not determined and the child died within 4 hours of admission. In children who develop a fulminant disease of pneumonia with
Combined multiple gene genealogies and phenotypic characters differentiate several species previously identified as Botryosphaeria dothidea
Bernard Slippers; Pedro W. Crous; Sandra Denman; Teresa A. Coutinho; Brenda D. Wingfield; Michael J. Wingfield
Botryosphaeria dothidea is one of the most commonly reported species in a genus of important pathogens of woody plants. This taxon generally is accepted to represent a species complex, and hence its identity remains unclear. Previous studies either have treated B. dothidea as the valid name for B. ribis and B. berengeriana or argued for them to be separate entities.
Harding, David; Rouse, Ted
Most companies do a thorough job of financial due diligence when they acquire other companies. But all too often, deal makers simply ignore or underestimate the significance of people issues in mergers and acquisitions. The consequences are severe. Most obviously, there's a high degree of talent loss after a deal's announcement. To make matters worse, differences in decision-making styles lead to infighting; integration stalls; and productivity declines. The good news is that human due diligence can help companies avoid these problems. Done early enough, it helps acquirers decide whether to embrace or kill a deal and determine the price they are willing to pay. It also lays the groundwork for smooth integration. When acquirers have done their homework, they can uncover capability gaps, points of friction, and differences in decision making. Even more important, they can make the critical "people" decisions-who stays, who goes, who runs the combined business, what to do with the rank and file-at the time the deal is announced or shortly thereafter. Making such decisions within the first 30 days is critical to the success of a deal. Hostile situations clearly make things more difficult, but companies can and must still do a certain amount of human due diligence to reduce the inevitable fallout from the acquisition process and smooth the integration. This article details the steps involved in conducting human due diligence. The approach is structured around answering five basic questions: Who is the cultural acquirer? What kind of organization do you want? Will the two cultures mesh? Who are the people you most want to retain? And how will rank-and-file employees react to the deal? Unless an acquiring company has answered these questions to its satisfaction, the acquisition it is making will be very likely to end badly. PMID:17432159
Dissociation in decision bias mechanism between probabilistic information and previous decision.
Kaneko, Yoshiyuki; Sakai, Katsuyuki
Target detection performance is known to be influenced by events in the previous trials. It has not been clear, however, whether this bias effect is due to the previous sensory stimulus, motor response, or decision. Also it remains open whether or not the previous trial effect emerges via the same mechanism as the effect of knowledge about the target probability. In the present study, we asked normal human subjects to make a decision about the presence or absence of a visual target. We presented a pre-cue indicating the target probability before the stimulus, and also a decision-response mapping cue after the stimulus so as to tease apart the effect of decision from that of motor response. We found that the target detection performance was significantly affected by the probability cue in the current trial and also by the decision in the previous trial. While the information about the target probability modulated the decision criteria, the previous decision modulated the sensitivity to target-relevant sensory signals (d-prime). Using functional magnetic resonance imaging (fMRI), we also found that activation in the left intraparietal sulcus (IPS) was decreased when the probability cue indicated a high probability of the target. By contrast, activation in the right inferior frontal gyrus (IFG) was increased when the subjects made a target-present decision in the previous trial, but this change was observed specifically when the target was present in the current trial. Activation in these regions was associated with individual-difference in the decision computation parameters. We argue that the previous decision biases the target detection performance by modulating the processing of target-selective information, and this mechanism is distinct from modulation of decision criteria due to expectation of a target. PMID:25999844
Radiation induced esophageal adenocarcinoma in a woman previously treated for breast cancer and renal cell carcinoma
Background Secondary radiation-induced cancers are rare but well-documented as long-term side effects of radiation in large populations of breast cancer survivors. Multiple neoplasms are rare. We report a case of esophageal adenocarcinoma in a patient treated previously for breast cancer and clear cell carcinoma of the kidney. Case presentation A 56?year-old non smoking woman, with no alcohol intake and no familial history of cancer; followed in the National Institute of Oncology of Rabat Morocco since 1999 for breast carcinoma, presented on consultation on January 2011 with dysphagia. Breast cancer was treated with modified radical mastectomy, 6 courses of chemotherapy based on CMF regimen and radiotherapy to breast, inner mammary chain and to pelvis as castration. Less than a year later, a renal right mass was discovered incidentally. Enlarged nephrectomy realized and showed renal cell carcinoma. A local and metastatic breast cancer recurrence occurred in 2007. Patient had 2 lines of chemotherapy and 2 lines of hormonotherapy with Letrozole and Tamoxifen assuring a stable disease. On January 2011, the patient presented dysphagia. Oesogastric endoscopy showed middle esophagus stenosing mass. Biopsy revealed adenocarcinoma. No evidence of metastasis was noticed on computed tomography and breast disease was controlled. Palliative brachytherapy to esophagus was delivered. Patient presented dysphagia due to progressive disease 4?months later. Jejunostomy was proposed but the patient refused any treatment. She died on July 2011. Conclusion We present here a multiple neoplasm in a patient with no known family history of cancers. Esophageal carcinoma is most likely induced by radiation. However the presence of a third malignancy suggests the presence of genetic disorders. PMID:22873795
FILE WITHIN 5 DAYS OF INCIDENT. (In the event of a serious or fatal injury or illness, notify within 24 hours. It is the supervisors responsibility to report lost time due to an occupational injury or disease. Failure to do so
within 24 hours. It is the supervisors responsibility to report lost time due to an occupational injury or disease. Failure to do so immediately may result in departmental fines. NOTE: PLEASE FILL IN EACH BLANK) OCCUPATIONAL ACCIDENT OR ILLNESS REPORT Name
Emergence of diplopia and oscillopsia due to Heimann-Bielschowsky phenomenon after cataract surgery.
Jeong, S-H; Oh, Y-M; Hwang, J-M; Kim, J S
The Heimann-Bielschowsky phenomenon (HBP) refers to coarse vertical oscillation of the eye with impaired vision. The ocular movements are strictly monocular, occurring only in the eye with amblyopia. The vertical oscillation is of equal velocity in both vertical directions, or may sometimes be greater in the downward than upward direction. HBP develops several years after loss of vision. It can be differentiated from dissociated nystagmus in spasmus nutans, congenital nystagmus and internuclear ophthalmoplegia based on the strict unilaterality, vertical direction and low frequency. Previously, only a few reports described the development of oscillopsia due to HBP after cataract surgery, which resolved spontaneously or responded to gabapentin. However, visual impairments due to diplopia or oscillopsia from HBP after cataract surgery have received little attention. We report a man who developed persistent vertical diplopia and oscillopsia due to HBP after a cataract operation, which markedly impaired his vision. PMID:18815421
Wildlife Impact Assessment and Summary of Previous Mitigation Related to Hydroelectric Projects in Montana, Volume One, Libby Dam Project, Operator, U.S. Army Corps of Engineers.
Yde, Chris A.
This assessment addresses the impacts to the wildlife populations and wildlife habitats due to the Libby Dam project on the Kootenai River and previous mitigation of these losses. The current assessment documents the best available information concerning the impacts to the wildlife populations inhabiting the project area prior to construction of the dam and creation of the reservoir. Many of the impacts reported in this assessment differ from those contained in the earlier document compiled by the Fish and Wildlife Service; however, this document is a thorough compilation of the available data (habitat and wildlife) and, though conservative, attempts to realistically assess the impacts related to the Libby Dam project. Where appropriate the impacts resulting from highway construction and railroad relocation were included in the assessment. This was consistent with the previous assessments.
Sustained bromocriptine therapy in previously untreated patients with Parkinson's disease
A J Lees; G M Stern
The progress of 50 previously untreated patients with idiopathic Parkinson's disease taking maximum tolerated doses of bromocriptine is compared with patients who had taken levodopa. Twenty-eight of the bromocriptine treated patients showed sustained benefit for at least one year and in five this persisted longer than five years. Fewer of the late complications of levodopa therapy occurred in those taking
Previous Fires Moderate Burn Severity of Subsequent Wildland
Previous Fires Moderate Burn Severity of Subsequent Wildland Fires in Two Large Western US Wilderness Areas Sean A. Parks,1,2 * Carol Miller,1 Cara R. Nelson,2 and Zachary A. Holden3 1 U.S.D.A. Forest, Mis- soula, Montana 59801, USA; 2 Department of Ecosystem and Conservation Sciences, College
I. INTRODUCTION Previous research in water treatment has been
McMaster University
I. INTRODUCTION Previous research in water treatment has been varied and extensive. In the past, water treatment research included remote plasma processes, such as ozone, UV and electron processes the knowledge gleaned from past research, PAED seems to be a viable water treatment option. PAED may provide
Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma
Adult Malignant Mesenchymoma; Adult Rhabdomyosarcoma; Alveolar Childhood Rhabdomyosarcoma; Childhood Malignant Mesenchymoma; Embryonal Childhood Rhabdomyosarcoma; Embryonal-botryoid Childhood Rhabdomyosarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Previously Untreated Childhood Rhabdomyosarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma
Combat Stressors Predicting Perceived Stress Among Previously Deployed Soldiers
Mary M. Mitchell; M. Shayne Gallaway; Amy Millikan; Michael R. Bell
While combat exposures are considered principle stressors in developing mental health problems, research suggests social support can reduce this risk. Using data from 1,592 previously deployed soldiers, we found five classes of soldiers based on their patterns of responses to items measuring perceived stress. In subsequent analyses, we found increased combat exposure predicted membership in classes with greater combat-related stress,
Identification of Lanning 90 as a previously uncataloged cataclysmic variable
A. W. Shafter; H. H. Lanning; R. K. Ulrich
Spectroscopic observations which reveal Lanning 90 to be a previously uncataloged cataclysmic variable are presented. Low-resolution spectra of the object display strong and broad emission lines of hydrogen and neutral helium superimposed on a continuum with roughly constant F-lambda. In addition to the Balmer and He I emision lines, the spectrum shows high excitation lines of He II, C II,
120 credits Previous college credits must be transferred
Delivery Online Credits 120 credits Previous college credits must be transferred into the program. Contact us for details. Tuition $397 per credit; financial aid is available Time Frame Varies based.colostate.edu/degrees/liberal-arts "After receiving my AA from Colorado Mountain College, I faced the dilemma of which college to attend
Endoscopic Retrograde Cholangiopancreatography in Patients with Previous Acute Coronary Syndrome
Koh, Han-Ra; Park, Chang-Hwan; Chung, Min-Woo; Park, Seon-Young; Hong, Young-Joon; Jeong, Myung-Ho; Kim, Hyun-Soo; Choi, Sung-Kyu; Rew, Jong-Sun
Background/Aims Endoscopic retrograde cholangiopancreatography (ERCP) is considered a high-risk procedure in patients with previous acute coronary syndrome (ACS); however, clinical studies are rare in the literature. The aim of this study was to investigate the safety and efficacy of ERCP in patients with previous ACS. Methods We retrospectively reviewed the medical records of patients with previous ACS who underwent ERCP between January 2007 and August 2012. The clinical characteristics, ERCP diagnoses, treatment results, and complications were analyzed. Results Fifty patients underwent ERCP an average of 41.6 months after ACS. The most common indication for ERCP was calculous cholangitis. After deep biliary cannulation, endoscopic sphincterotomy, biliary stone removal and endoscopic biliary drainage were successfully performed. Immediate postsphincterotomy bleeding occurred in seven patients, which was successfully controlled using endoscopic therapy. Elevation of cardiac troponin I levels were observed in three patients (6%) before ERCP, and all of these patients were diagnosed with pancreatobiliary disease combined with recurrent ACS, which was treated with coronary artery stent insertion (n=2) and balloon angioplasty (n=1). Conclusions Therapeutic ERCP is effective and safe in patients with previous ACS. Cardiac troponin I elevation should be considered a warning sign for recurrent ACS in patients who undergo ERCP. PMID:25368756
37. Closeup of stairs in previous photo, leading up to ...
Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey
37. Close-up of stairs in previous photo, leading up to El Macho and down to Plaza de Armas, from Santa Barbara Bastion, viewed from northwest - Castillo de San Felipe del Morro, Northwest end of San Juan, San Juan, San Juan Municipio, PR
Wildfires may contribute more to global warming than previously predicted
- 1 - Wildfires may contribute more to global warming than previously predicted July 9, 2013 and wildlife health, and interacting with sunlight to affect climate. But measurements taken during the 2011 Dubey, "Both components can potentially increase climate warming by increased light absorption." The Las
Production in vitro of the Toxin of Bacillus anthracis Previously Recognized in vivo
PATRICIA W. HARRIS-SMITH; H. Smith; J. Keppie
SUMMARY: A lethal oedema-producing toxin has been made in vitm in serum cultures of Bacillus anthracis which is identical with the toxin originally recognized in Wiuo. Toxin is produced by the attenuated immunogenic Sterne strain as well as by the virulent N.P. strain. Previous non-recognition of the toxin in cultures was due to its early appearance and rapid disappearance under
Superinfection in mice previously infected with Mycobacterium leprae.
Levy, L
Previous studies of the protection of mice by prior infection with Mycobacterium leprae in one hind footpad against challenge with M.leprae in the opposite hind footpad had produced conflicting results; therefore, the problem was restudied. In several experiments, BALB/c mice were inoculated first in the right hind footpad with 5,000 M. leprae and then challenged in the left hind footpad with 5,000 M. leprae of the same strain at intervals after primary infection, at the same time that uninfected mice were inoculated. Multiplication of the M. leprae of the secondary challenge inoculum occurred at the same rate and to the same level as multiplication in uninfected mice when challenges were made soon after primary infection. Multiplication was slowed but proceeded to the same level in previously infected as in uninfected mice when the challenges were administered between 76 and 106 days after primary infection (47 to 17 days before the M. leprae of the primary inoculum had multiplied to the level of 10-6 organisms per footpad). Finally, the M. leprae of a secondary challenge administered at the time that the organisms of the primary inoculum had multiplied to 10-6 per footpad or later not only multiplied more slowly in previously infected than in control animals, but multiplication in the previously infected animals reached a lower maximum. These results are similar to those observed when mice previously infected with M. bovis (BCG), M. marinum, Toxoplasma gondii, or Besnoitia jellisoni were challenged with M. leprae. PMID:1091561
Superinfection in mice previously infected with Mycobacterium leprae.
Levy, L
Previous studies of the protection of mice by prior infection with Mycobacterium leprae in one hind footpad against challenge with M.leprae in the opposite hind footpad had produced conflicting results; therefore, the problem was restudied. In several experiments, BALB/c mice were inoculated first in the right hind footpad with 5,000 M. leprae and then challenged in the left hind footpad with 5,000 M. leprae of the same strain at intervals after primary infection, at the same time that uninfected mice were inoculated. Multiplication of the M. leprae of the secondary challenge inoculum occurred at the same rate and to the same level as multiplication in uninfected mice when challenges were made soon after primary infection. Multiplication was slowed but proceeded to the same level in previously infected as in uninfected mice when the challenges were administered between 76 and 106 days after primary infection (47 to 17 days before the M. leprae of the primary inoculum had multiplied to the level of 10-6 organisms per footpad). Finally, the M. leprae of a secondary challenge administered at the time that the organisms of the primary inoculum had multiplied to 10-6 per footpad or later not only multiplied more slowly in previously infected than in control animals, but multiplication in the previously infected animals reached a lower maximum. These results are similar to those observed when mice previously infected with M. bovis (BCG), M. marinum, Toxoplasma gondii, or Besnoitia jellisoni were challenged with M. leprae. PMID:1091561
Massive pleural effusion due to metastasis of prostate cancer.
dos Santos, V M; Zembrzuski, M M da Silva; Gouvea, I P; Nery, N S; dos Santos, L A M
We describe the case of a 72-year old male with pleural effusion associated with prostate cancer. There was a previous history of tobacco smoking (pack/year: 47) and of total prostatectomy followed by external beam radiation therapy seven years previously for prostate cancer. Furthermore, he was submitted to orchiectomy plus non-steroidal anti-androgen blockage, in addition to docetaxel-based chemotherapy and prednisone. After the beginning of chemotherapy, a progressive elevation in prostate specific antigen (PSA) levels was observed. On admission, he presented with fever, weight loss, and respiratory symptoms due to a massive right pleural effusion. Fluid samples obtained by needle aspiration showed haemorrhagic exudates without malignant cells. Pleural metastasis were detected by thorax imaging studies, and biopsy samples revealed prostate adenocarcinoma as the origin of his pleural effusion. Pleural fluid was drained and talc pleurodesis was performed. This report aims to describe the occurrence of massive pleural effusion due to metastasis of prostate cancer and emphasizes the role of pleural biopsy with immunohistochemical studies to characterize this diagnosis. PMID:22512233
Uterine arteriovenous malformation caused by intrauterine instrumentation for laparoscopic surgery due to left tubal pregnancy
Chang, Kylie Hae-Jin; Park, Jong-Kyu; Park, Sung-Ho; Kim, Hong-Bae
Uterine arteriovenous malformation (AVM) is a rare entity in gynecology with fewer than 100 cases reported in the literature. Due to abnormal connection between arteries and veins without an intervening capillary system, recurrent and profuse vaginal bleeding is the most common symptom which can be potentially life-threatening. Uterine AVM can be either congenital or acquired. Acquired AVM is reported as a consequence of previous uterine trauma such as curettage procedures, caesarean section or pelvic surgery. It is also associated with infection, retained product of conception, gestational trophoblastic disease, malignancy and exposure to diethlystilboestrol. We herein report a case of acquired uterine AVM located on the right lateral wall after intrauterine instrumentation for laparoscopic left salpingectomy due to left tubal pregnancy. The patient was successfully treated with embolization. PMID:25264537
A difficult case: omental transposition flap reconstruction of a large radionecrotic axillary ulcer in a patient with extensive previous abdominal surgery.
Hartmann, Christoph E A; Ko, Loretta W L; Ion, Lucion; Jemec, Barbara
Radionecrotic ulcers due to breast cancer treatment is a highly morbid and disabling condition, causing pain, malodour, need for frequent dressings, reduced range of shoulder movements and an unacceptable cosmetic appearance. In patients with radiotherapy to the chest and/or axilla and general poor health the usual reconstructive options may not be suitable due to regional tissue damage and inappropriate long anaesthetic time, respectively. Described procedures include the pedicled latisimus dorsi flap, transverse rectus abdominal flap (TRAM) and omental transposition flap, as well as free tissue transfer (e.g. free TRAM, DIEP). We report a case of a morbidly obese female patient presenting with a large radionecrotic ulcer in her left axilla, following mastectomy, axillary clearance and local radiotherapy to left chest and axilla for breast cancer. She underwent reconstruction using an omental transposition flap, despite previous abdominal surgery. PMID:22871429
Unilateral compressive optic neuropathy due to skull hyperostosis secondary to nutritional vitamin A deficiency
Zayed, Mohammed G.; Hickman, Simon J.; Batty, Ruth; McCloskey, Eugene V.; Pepper, Irene M.
Summary We report a 17-year-old boy who presented with a chronic left unilateral optic neuropathy. Computerized tomography and magnetic resonance imaging demonstrated compression of the left optic nerve due to skull hyperostosis. He was found to be profoundly vitamin A deficient secondary to an unusual diet consisting predominantly of potato chips and crisps. Skull hyperostosis with cranial neuropathies and other neurological abnormalities has been described in growing animals fed vitamin A deficient diets but has not been previously reported in humans. PMID:26136803
The Stability of Working Memory: Do Previous Tasks Influence Complex Span?
ERIC Educational Resources Information Center
Healey, M. Karl; Hasher, Lynn; Danilova, Elena
Schmeichel (2007) reported that performing an initial task before completing a working memory span task can lower span scores and suggested that the effect was due to depleted cognitive resources. We showed that the detrimental effect of prior tasks depends on a match between the stimuli used in the span task and the preceding task. A taskģ
Previously Unrecognized Large Lunar Impact Basins Revealed by Topographic Data
NASA Technical Reports Server (NTRS)
Frey, Herbert V.
The discovery of a large population of apparently buried impact craters on Mars, revealed as Quasi- Circular Depressions (QCDs) in Mars Orbiting Laser Altimeter (MOLA) data [1,2,3] and as Circular Thin Areas (CTAs) [4] in crustal thickness model data [5] leads to the obvious question: are there unrecognized impact features on the Moon and other bodies in the solar system? Early analysis of Clementine topography revealed several large impact basins not previously known [6,7], so the answer certainly is "Yes." How large a population of previously undetected impact basins, their size frequency distribution, and how much these added craters and basins will change ideas about the early cratering history and Late Heavy Bombardment on the Moon remains to be determined. Lunar Orbiter Laser Altimeter (LOLA) data [8] will be able to address these issues. As a prelude, we searched the state-of-the-art global topographic grid for the Moon, the Unified Lunar Control Net (ULCN) [9] for evidence of large impact features not previously recognized by photogeologic mapping, as summarized by Wilhelms [lo].
Microbial phyllosphere populations are more complex than previously realized
Yang, Ching-Hong; Crowley, David E.; Borneman, James; Keen, Noel T.
Phyllosphere microbial communities were evaluated on leaves of field-grown plant species by culture-dependent and -independent methods. Denaturing gradient gel electrophoresis (DGGE) with 16S rDNA primers generally indicated that microbial community structures were similar on different individuals of the same plant species, but unique on different plant species. Phyllosphere bacteria were identified from Citrus sinesis (cv. Valencia) by using DGGE analysis followed by cloning and sequencing of the dominant rDNA bands. Of the 17 unique sequences obtained, database queries showed only four strains that had been described previously as phyllosphere bacteria. Five of the 17 sequences had 16S similarities lower than 90% to database entries, suggesting that they represent previously undescribed species. In addition, three fungal species were also identified. Very different 16S rDNA DGGE banding profiles were obtained when replicate cv. Valencia leaf samples were cultured in BIOLOG EcoPlates for 4.5 days. All of these rDNA sequences had 97¢100% similarity to those of known phyllosphere bacteria, but only two of them matched those identified by the culture independent DGGE analysis. Like other studied ecosystems, microbial phyllosphere communities therefore are more complex than previously thought, based on conventional culture-based methods. PMID:11274410
Research Paper Abstract: Several previous studies have observed that species
Reekie, Ed
and P. rubens using growth anal- ysis. The large seeded species (P. abies) responded more posi- tively as in plants from small seeds. Elevated CO2 increased relative growth rate to a greater extent in individuals in understanding the factors affecting plant success at current atmospheric CO2 levels due to the eleva- tion of CO
[Keratitis due to Acanthamoeba].
Pķrez-Irezßbal, Julio; MartĒnez, Inķs; Isasa, Patricia; Barr¾n, Jorge
Free-living amebae appertaining to the genus Acanthamoeba, Naegleria and Balamuthia are the most prevalent protozoa found in the environment. These amebae have a cosmopolitan distribution in soil, air and water, providing multiple opportunities for contacts with humans and animals, although they only occasionally cause disease. Acanthamoeba spp. are the causative agent of granulomatous amebic encephalitis, a rare and often fatal disease of the central nervous system, and amebic keratitis, a painful disease of the eyes. Keratitis usually follows a chronic course due to the delay in diagnosis and subsequent treatment. The clear increase in Acanthamoeba keratitis in the last 20 years is related to the use and deficient maintenance of contact lenses, and to swimming while wearing them. The expected incidence is one case per 30,000 contact lens wearers per year, with 88% of cases occurring in persons wearing hydrogel lenses. This review presents information on the morphology, life-cycle and epidemiology of Acanthamoeba, as well as on diagnostic procedures (culture), appropriate antimicrobial therapy, and prevention measures. PMID:17125668
Simultaneous Colonic Obstruction and Hydroureteronephrosis due to Mesenteric Fibromatosis.
Jung, Sung Hoon; Paik, Chang Nyol; Jung, Ji Han; Lee, Kang-Moon; Chung, Woo Chul; Yang, Jin-Mo
Mesenteric fibromatosis (MF) is a rare benign mesenchymal lesion that can occur throughout the gastrointestinal tract, especially small bowel. Its biological behavior is intermediate between benign fibrous tissue proliferation and malignant fibrosarcoma. In previously reported cases of MF, we could find colonic obstruction or ureter obstruction, but simultaneous involvement of colon and ureter was not able to be seen. We described a patient that presented with colonic obstruction and hydroureteronephrosis due to MF at sigmoid colon which mimicked submucosal tumor such as gastrointestinal tumor. This case resulted in a positive positron emission tomography scan suggesting malignant neoplasm, but beta-catenin positivity on immunohistochemical staining separated MF from gastrointestinal stromal tumor and sclerosing mesenteritis. The clinical course of the patient was improved after surgical resection. PMID:20431749
Simultaneous Colonic Obstruction and Hydroureteronephrosis due to Mesenteric Fibromatosis
Jung, Sung Hoon; Jung, Ji Han; Lee, Kang-Moon; Chung, Woo Chul; Yang, Jin-Mo
Mesenteric fibromatosis (MF) is a rare benign mesenchymal lesion that can occur throughout the gastrointestinal tract, especially small bowel. Its biological behavior is intermediate between benign fibrous tissue proliferation and malignant fibrosarcoma. In previously reported cases of MF, we could find colonic obstruction or ureter obstruction, but simultaneous involvement of colon and ureter was not able to be seen. We described a patient that presented with colonic obstruction and hydroureteronephrosis due to MF at sigmoid colon which mimicked submucosal tumor such as gastrointestinal tumor. This case resulted in a positive positron emission tomography scan suggesting malignant neoplasm, but ?-catenin positivity on immunohistochemical staining separated MF from gastrointestinal stromal tumor and sclerosing mesenteritis. The clinical course of the patient was improved after surgical resection. PMID:20431749
Two cases of dermatoses koebnerizing within fields of previous radiotherapy.
Hellen, R; Kiely, C; Murad, A; Mulligan, N; Coffey, J; Lenane, P; Moloney, F J
We describe two patients with newly diagnosed dermatoses localizing to the radiotherapy field following treatment for breast cancer. Patient 1 was a 53-year-old woman who developed bullous morphoea on her left breast twoĀyears after radiotherapy. Patient 2 was a 43-year-old woman who developed urticaria pigmentosa on her right breast eightĀmonths after radiotherapy and similar lesions gradually developed beyond the radiotherapy field. Both patients experienced a significant delay in diagnosis due to diagnostic confusion and concern over breast cancer recurrence. Irradiated skin demonstrates gradual and sustained alterations in fibrosis due to the production of long-lived cytokines and chemokines. These changes can induce a koebnerizing response in conditions such as morphoea and urticaria pigmentosa. We explore the mechanisms behind radiotherapy-induced skin changes, and highlight the potential for radiotherapy to exacerbate or unmask underlying dermatoses and systemic disease in the months and years following treatment. PMID:25224250
Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia
Chen, Bin-Bin; Song, Feng-Wei; Sun, Zhao-Hui; Yang, Yi
AIM To assess the quantitative association between anisometropia magnitude and the losses of resolution and contrast sensitivity; and to exemplify how the function of fusion and stereopsis vary with anisometropia magnitude (AM) in previously untreated anisometropic amblyopes. METHODS A total of 57 patients with previously untreated anisometropic amblyopia without strabismus (range: 8-35 years), were measured refractive error, best corrected visual acuity (BCVA), fusion and stereopsis, and 48 patients have completed contrast sensitivity function test. AM was determined by dioptric vector addition model, and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow eyes. RESULTS AM was significantly correlated with both amblyopia depth (Pearson R=0.728, P<0.001) and the inter-ocular difference of the area under the log contrast sensitivity function (AULCSF) (R=0.505, P<0.001). Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated (R=0.761, P<0.001). The more severity of amblyopia, the poorer levels of contrast sensitivity. Most pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis, but when AM were more than 3.0D, especially for the anisometropes whose AM was more than 6.0D, fusion and stereopsis function were seriously impaired. CONCLUSION In the patients with previously untreated anisometropia amblyopia, higher degree of anisometropia is significantly associated with deeper amblyopia, worse contrast sensitivity, fusion and stereopsis functions. PMID:24195034
Vorapaxar in Patients With Diabetes Mellitus and Previous Myocardial Infarction
Cavender, Matthew A.; Scirica, Benjamin M.; Bonaca, Marc P.; Angiolillo, Dominick J.; Dalby, Anthony J.; Dellborg, Mikael; Morais, Joao; Murphy, Sabina A.; Ophuis, Ton Oude; Tendera, Michal; Braunwald, Eugene
BackgroundŚ Vorapaxar reduces cardiovascular death, myocardial infarction (MI), or stroke in patients with previous MI while increasing bleeding. Patients with diabetes mellitus (DM) are at high risk of recurrent thrombotic events despite standard therapy and may derive particular benefit from antithrombotic therapies. The Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events-TIMI 50 trial was a randomized, double-blind, placebo-controlled trial of vorapaxar in patients with stable atherosclerosis. Methods and ResultsŚ We examined the efficacy of vorapaxar in patients with and without DM who qualified for the trial with a previous MI. Because vorapaxar is contraindicated in patients with a history of stroke or transient ischemic attack, the analysis (n=16 896) excluded such patients. The primary end point of cardiovascular death, MI, or stroke occurred more frequently in patients with DM than in patients without DM (rates in placebo group: 14.3% versus 7.6%; adjusted hazard ratio, 1.47; P<0.001). In patients with DM (n=3623), vorapaxar significantly reduced the primary end point (11.4% versus 14.3%; hazard ratio, 0.73 [95% confidence interval, 0.60¢0.89]; P=0.002) with a number needed to treat to avoid 1 major cardiovascular event of 29. The incidence of moderate/severe bleeding was increased with vorapaxar in patients with DM (4.4% versus 2.6%; hazard ratio, 1.60 [95% confidence interval, 1.07¢2.40]). However, net clinical outcome integrating these 2 end points (efficacy and safety) was improved with vorapaxar (hazard ratio, 0.79 [95% confidence interval, 0.67¢0.93]). ConclusionsŚ In patients with previous MI and DM, the addition of vorapaxar to standard therapy significantly reduced the risk of major vascular events with greater potential for absolute benefit in this group at high risk of recurrent ischemic events. Clinical Trial RegistrationŚ URL: http://www.clinicaltrials.gov. Unique identifier: NCT00526474. PMID:25681464
Implementing a Clinical Research Management System: One Institution's Successful Approach Following Previous Failures.
Campion, Thomas R; Blau, Vanessa L; Brown, Scott W; Izcovich, Daniel; Cole, Curtis L
Clinical research management systems (CRMSs) can facilitate research billing compliance and clinician awareness of study activities when integrated with practice management and electronic health record systems. However, adoption of CRMSs remains low, and optimal approaches to implementation are unknown. This case report describes one institution's successful approach to organization, technology, and workflow for CRMS implementation following previous failures. Critical factors for CRMS success included organizational commitment to clinical research, a dedicated research information technology unit, integration of research data across disparate systems, and centralized system usage workflows. In contrast, previous failed approaches at the institution lacked a mandate and mechanism for change, received support as a business rather than research activity, maintained data in separate systems, and relied on inconsistent distributed system usage workflows. To our knowledge, this case report is the first to describe CRMS implementation success and failures, which can assist practitioners and academic evaluators. PMID:25954570
Previous prenatal loss as a predictor of perinatal depression and anxiety
Blackmore, Emma Robertson; C¶tķ-Arsenault, Denise; Tang, Wan; Glover, Vivette; Evans, Jonathan; Golding, Jean; OÆConnor, Thomas G.
Background Prenatal loss, the death of a fetus/child through miscarriage or stillbirth, is associated with significant depression and anxiety, particularly in a subsequent pregnancy. Aims This study examined the degree to which symptoms of depression and anxiety associated with a previous loss persisted following a subsequent successful pregnancy. Method Data were derived from the Avon Longitudinal Study of Parents and Children cohort, a longitudinal cohort study in the west of England that has followed mothers from pregnancy into the postnatal period. A total of 13 133 mothers reported on the number and conditions of previous perinatal losses and provided self-report measures of depression and anxiety at 18 and 32 weeksÆ gestation and at 8 weeks and 8, 21 and 33 months postnatally. Controls for pregnancy outcome and obstetric and psychosocial factors were included. Results Generalised estimating equations indicated that the number of previous miscarriages/stillbirths significantly predicted symptoms of depression (? = 0.18, s.e. = 0.07, P<0.01) and anxiety (? = 0.14, s.e. = 0.05, P<0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors. This association remained constant across the pre- and postnatal period, indicating that the impact of a previous prenatal loss did not diminish significantly following the birth of a healthy child. Conclusions Depression and anxiety associated with a previous prenatal loss shows a persisting pattern that continues after the birth of a subsequent (healthy) child. Interventions targeting women with previous prenatal loss may improve the health outcomes of women and their children. PMID:21372060
Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: Clinical and pathological variability within a kindred
David O. Hutchinson; Amanda Charlton; Nigel G. Laing; Biljana Ilkovski; Kathryn N. North
Nemaline Myopathy with Intranuclear Rods is a rare variant of nemaline myopathy, due in almost all instances to mutation of ACTA1, the gene encoding skeletal muscle ?-actin. We describe the novel autosomal dominant occurrence in a three-generation kindred, and review previously reported cases. Onset of myopathic symptoms in our kindred was in infancy or early childhood. Beyond infancy, limb muscle
Delayed seizure-like activity following analytically confirmed use of previously unreported synthetic cannabinoid analogues.
Schep, L J; Slaughter, R J; Hudson, S; Place, R; Watts, M
Synthetic cannabinoid use has become widespread, leading to increased burdens on health care providers. Symptoms range from agitation and psychosis to seizures and acute kidney injury. We report a case where a patient was assessed and treated twice within 12 h for seizures following synthetic cannabinoid intoxication. Blood sample determinations showed low concentrations of analogues not previously reported, some of which are legal. Clinicians should be aware that synthetic cannabinoids may cause an array of severe health consequences. Given the ever evolving structure of available analogues, clinicians must also be prepared for other unexpected adverse effects. PMID:25233895
Elijah Watt Sells Award: A Study of Previous Winners
ERIC Educational Resources Information Center
Husted, Susan; Pinto, Joann; Romero, Silvia
This paper reports the results of a survey of winners of the Elijah Watt Sells award. We ask them about the determinants of their success, which might be useful to other students preparing for the CPA exam. The winners graduated from different universities, not necessarily the ones ranked top, and almost all of them participated in a reviewģ
Ureteric foreign body following previous aorto-iliac graft
da Silva, Vitor; Taylor, Jonathan
Foreign bodies in the ureter are extremely rare. We report a case of an 82-year-old man who, after an incidental presentation with asymptomatic hydroureteronephrosis, had an intraureteric foreign body. The patient was managed with atraumatic endoscopic extraction of the specimen.
High diversity of alpha-globin haplotypes in a Senegalese population, including many previously unreported variants.
Martinson, J J; Excoffier, L; Swinburn, C; Boyce, A J; Harding, R M; Langaney, A; Clegg, J B
RFLP haplotypes at the alpha-globin gene complex have been examined in 190 individuals from the Niokolo Mandenka population of Senegal: haplotypes were assigned unambiguously for 210 chromosomes. The Mandenka share with other African populations a sample size-independent haplotype diversity that is much greater than that in any non-African population: the number of haplotypes observed in the Mandenka is typically twice that seen in the non-African populations sampled to date. Of these haplotypes, 17.3% had not been observed in any previous surveys, and a further 19.1% have previously been reported only in African populations. The haplotype distribution shows clear differences between African and non-African peoples, but this is on the basis of population-specific haplotypes combined with haplotypes common to all. The relationship of the newly reported haplotypes to those previously recorded suggests that several mutation processes, particularly recombination as homologous exchange or gene conversion, have been involved in their production. A computer program based on the expectation-maximization (EM) algorithm was used to obtain maximum-likelihood estimates of haplotype frequencies for the entire data set: good concordance between the unambiguous and EM-derived sets was seen for the overall haplotype frequencies. Some of the low-frequency haplotypes reported by the estimation algorithm differ greatly, in structure, from those haplotypes known to be present in human populations, and they may not represent haplotypes actually present in the sample. PMID:7485171
Mediastinal involvement in lymphangiomatosis: a previously unreported MRI sign
Vikas Shah; Sachit Shah; Alex Barnacle; Neil J. Sebire; Penelope Brock; John I. Harper; Kieran McHugh
BackgroundĀĀMultifocal lymphangiomatosis is a rare systemic disorder affecting children. Due to its rarity and wide spectrum of clinical,\\u000a histological and imaging features, establishing the diagnosis of multifocal lymphangiomatosis can be challenging.\\u000a \\u000a \\u000a \\u000a \\u000a ObjectivesĀĀThe purpose of this study was to describe a new imaging sign in this disorder: paraspinal soft tissue and signal abnormality\\u000a at MRI.\\u000a \\u000a \\u000a \\u000a \\u000a Materials and methodsĀĀWe retrospectively reviewed the
Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer
Tatl?, Ali Murat; G÷ksu, Sema Sezgin; Arslan, Deniz; Ba?sorgun, Cumhur ?brahim; Co?kun, Hasan ?enol
Bisphosphonates are widely used in the treatment of breast cancer with bone metastases. We report a case of a female with breast cancer presented with a rash around a previous mastectomy site and a discharge lesion on her right chest wall in August 2010. Biopsy of the lesion showed dystrophic calcification and metaplastic bone formation. The patient's history revealed a long term use of zoledronic acid for the treatment of breast cancer with bone metastasis. We stopped the treatment since we believed that the cutaneous dystrophic calcification could be associated with her long term bisphosphonate therapy. Adverse cutaneous events with bisphosphonates are very rare, and dystrophic calcification has not been reported previously. The dystrophic calcification and metaplastic bone formation in this patient are thought to be due to long term bisphosphonate usage. PMID:23956898
Optimal temperature for malaria transmission is dramaticallylower than previously predicted
Mordecai, Eerin A.; Paaijmans, Krijin P.; Johnson, Leah R.; Balzer, Christian; Ben-Horin, Tal; de Moor, Emily; McNally, Amy; Pawar, Samraat; Ryan, Sadie J.; Smith, Thomas C.; Lafferty, Kevin D.
The ecology of mosquito vectors and malaria parasites affect the incidence, seasonal transmission and geographical range of malaria. Most malaria models to date assume constant or linear responses of mosquito and parasite life-history traits to temperature, predicting optimal transmission at 31 ░C. These models are at odds with field observations of transmission dating back nearly a century. We build a model with more realistic ecological assumptions about the thermal physiology of insects. Our model, which includes empirically derived nonlinear thermal responses, predicts optimal malaria transmission at 25 ░C (6 ░C lower than previous models). Moreover, the model predicts that transmission decreases dramatically at temperatures > 28 ░C, altering predictions about how climate change will affect malaria. A large data set on malaria transmission risk in Africa validates both the 25 ░C optimum and the decline above 28 ░C. Using these more accurate nonlinear thermal-response models will aid in understanding the effects of current and future temperature regimes on disease transmission.
A previously undescribed potyvirus isolated and characterized from arborescent Brugmansia.
Damsteegt, Vernon D; Stone, Andrew L; Smith, Oney P; McDaniel, Lawrence; Sherman, Diana J; Dardick, Chris; Hammond, John; Jordan, Ramon; Schneider, William L
A suspected virus disease was identified from an arborescent Brugmansia x candida Pers. (syn. Datura candida Pers.) tree. The causal agent was aphid transmissible at low rates. Viral particles were purified from infected tobacco tissue, analyzed, and purified virions were inoculated into healthy tobacco plants to recreate the symptoms. The virions had a mean length of 720-729 nm, and infected cells contained inclusion bodies typical of potyvirus infections. Analysis of infected tissues and purified virions with a panel of potyvirus-specific antibodies confirmed identification as a potyvirus. Viral host range, dilution end point, thermal tolerance and aphid transmission characteristics were examined. The viral genome (9761 nt) is typical of potyviruses, with the closest related potyvirus being pepper mottle virus, at 72 % nt sequence identity. Based on conventions for naming novel potyviruses, the virus was determined to be a member of a previously undescribed species, tentatively named "Brugmansia mosaic virus" (BruMV). PMID:23381392
Detecting Area Sensitivity: A Comment on Previous Studies
ABSTRACT.ŚSeveral studies have reported,that some,grassland birds are area sensitive; they exhibit a nonrandom avoidance of small fields. The methods used to test for area sensitivity, however, differed among studies. Some investigators sampled fields with sampling effort pro- portional to field size, whereas others used equal sampling effort in all fields. We created a simulation model,with the same,number,of fields and field
Leukemic transformation of essential thrombocythemia without previous cytoreductive treatment
P. O. Andersson; B. Ridell; H. Wadenvik; J. Kutti
Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature.\\u000a In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and 32P is well established, and recent reports also indicate a certain leukemogenic effect of hydroxyurea in these disorders. However,\\u000a leukemic transformation in untreated ET seems to be a rare
Estimating areas contributing recharge to wells, lessons from previous studies
Franke, O. Lehn; Reilly, T.E.; Pollock, D.W.; LaBaugh, J.W.
Factors relating to the estimation of areas contributing recharge to wells, such as complexity of the ground-water flow system, effects of changing hydrologic conditions, and effects of well-screen locations and pumping rates, are reviewed. The point of view that simulation is the best means to obtain physically based estimates of contributing areas is emphasized. An extensive list of USGS reports that include estimation of contributing areas is provided.
Risk of oesophageal cancer among patients previously hospitalised with eating disorder
Brewster, David H.; Nowell, SiŌn L.; Clark, David N.
Background It has been suggested that the risk of oesophageal adenocarcinoma might be increased in patients with a history of eating disorders due to acidic damage to oesophageal mucosa caused by self-induced vomiting practiced as a method of weight control. Eating disorders have also been associated with risk factors for squamous cell carcinoma of the oesophagus, including alcohol use disorders, as well as smoking and nutritional deficiencies, which have been associated with both main sub-types of oesophageal cancer. There have been several case reports of oesophageal cancer (both main sub-types) arising in patients with a history of eating disorders. Methods We used linked records of hospitalisation, cancer registration and mortality in Scotland spanning 1981¢2012 to investigate the risk of oesophageal cancer among patients with a prior history of hospitalisation with eating disorder. The cohort was restricted to patients aged ?10 years and <60 years at the date of first admission with eating disorder. Disregarding the first year of follow-up, we calculated indirectly standardised incidence ratios using the general population as the reference group to generate expected numbers of cases (based on age-, sex-, socio-economic deprivation category-, and calendar period-specific rates of disease). Results After exclusions, the cohort consisted of 3617 individuals contributing 52,455 person-years at risk. The median duration of follow-up was 13.9 years. Seven oesophageal cancers were identified, as compared with 1.14 expected, yielding a standardised incidence ratio of 6.1 (95% confidence interval: 2.5¢12.6). All were squamous cell carcinomas arising in females with a prior history of anorexia nervosa. Conclusions Patients hospitalised previously with eating disorders are at increased risk of developing oesophageal cancer. Confounding by established risk factors (alcohol, smoking, and nutritional deficiency) seems a more likely explanation than acidic damage through self-induced vomiting because none of the incident cases of oesophageal cancer were adenocarcinomas, and because the study cohort had higher than background rates of hospitalisation with alcohol-related conditions and chronic obstructive pulmonary disease. PMID:25769223
Twelve previously unknown phage genera are ubiquitous in global oceans
Holmfeldt, Karin [University of Arizona] [University of Arizona; Solonenko, Natalie [University of Arizona] [University of Arizona; Shah, Manesh B [ORNL] [ORNL; Corrier, Kristen L [ORNL] [ORNL; Riemann, Lasse [University of Copenhagen] [University of Copenhagen; Verberkmoes, Nathan C [ORNL] [ORNL; Sullivan, Matthew B [University of Arizona] [University of Arizona
Viruses are fundamental to ecosystems ranging from oceans to humans, yet our ability to study them is bottlenecked by the lack of ecologically relevant isolates, resulting in unknowns dominating culture-independent surveys. Here we present genomes from 31 phages infecting multiple strains of the aquatic bacterium Cellulophaga baltica (Bacteroidetes) to provide data for an underrepresented and environmentally abundant bacterial lineage. Comparative genomics delineated 12 phage groups that (i) each represent a new genus, and (ii) represent one novel and four wellknown viral families. This diversity contrasts the few well-studied marine phage systems, but parallels the diversity of phages infecting human-associated bacteria. Although all 12 Cellulophaga phages represent new genera, the podoviruses and icosahedral, nontailed ssDNA phages were exceptional, with genomes up to twice as large as those previously observed for each phage type. Structural novelty was also substantial, requiring experimental phage proteomics to identify 83% of the structural proteins. The presence of uncommon nucleotide metabolism genes in four genera likely underscores the importance of scavenging nutrient-rich molecules as previously seen for phages in marine environments. Metagenomic recruitment analyses suggest that these particular Cellulophaga phages are rare and may represent a first glimpse into the phage side of the rare biosphere. However, these analyses also revealed that these phage genera are widespread, occurring in 94% of 137 investigated metagenomes. Together, this diverse and novel collection of phages identifies a small but ubiquitous fraction of unknown marine viral diversity and provides numerous environmentally relevant phage host systems for experimental hypothesis testing.
Comparative and physical mapping of 112 previously reported and 105 new porcine microsatellites
Technology Transfer Automated Retrieval System (TEKTRAN)
Considerable effort is now being put into mapping Quantitative Trait Loci in swine. When a QTL region has been identified the next step is to fine map the region and narrow the chromosomal location harboring the QTL. A lot of information can be obtained from the genomes of well studied species such ...
Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies
Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.
This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway
Previous Gestational Diabetes Mellitus and Markers of Cardiovascular Risk
Vrachnis, Nikolaos; Augoulea, Areti; Iliodromiti, Zoe; Lambrinoudaki, Irene; Sifakis, Stavros; Creatsas, George
The prevalence of gestational diabetes mellitus (GDM) in the developed world has increased at an alarming rate over the last few decades. GDM has been shown to be associated with postpartum diabetes, insulin resistance, hypertension, and dyslipidemia. A history of previous GDM (pGDM), associated or not with any of these metabolic abnormalities, can increase the risk of developing not only type 2 diabetes mellitus but also cardiovascular disease (CVD) independent of a diagnosis of type 2 diabetes later in life. In this paper we discuss the relationship among inflammatory markers, metabolic abnormalities, and vascular dysfunction in women with pGDM. We also review the current knowledge on metabolic modifications occurring in normal pregnancy and the link between alterations of a normal metabolic state with the long-term maternal complications that may result in increased CVD risk. Our review of studies on pGDM prompts us to recommend that these women be considered a population at risk for later CVD events, which however could be avoided via the use of specially designed follow-up programs in the future. PMID:22518122
Panic attacks may reveal previously unsuspected chronic disseminated lyme disease.
Sherr, V T
The author describes the histories of three patients with panic-like episodes that turned out to be related to underlying, previously unsuspected tick-borne diseases. Each woman experienced symptoms that are not usual in panic disorder but are typical of neurological Lyme disease, including exquisite sensitivity to light, touch, and sounds, joint pain often in combination with cognitive changes including mental fogginess and loss of recent memory, and some degree of bizarre, shifting, and often excruciating neurological pain. Because these symptoms are atypical of primary panic disorder, they were very helpful in alerting the clinician to suspect an underlying physical illness. In each case, the results of testing revealed positive hallmarks of disseminated Lyme and other tick-borne diseases, including Lyme borreliosis caused by the spirochete, Borrelia burgdorferi, babesiosis, and ehrlichiosis. Since beginning treatment with intensive doses of appropriate antimicrobial medications for their tick-borne infections, all three patients have become free of panic attacks. Treatment of their infections by a specialist in Lyme disease allowed one of the women to discontinue anti-anxiety medication completely and another to reduce the dose of medication to occasional use only. The third patient is no longer anxious but her depression is resolving more slowly despite the ongoing use of an antidepressant. Two of the patients have also needed ongoing medication for pain and other symptoms of late-stage, neurological Lyme disease. PMID:15990495
Nodular Fasciitis of the Breast Previously Misdiagnosed as Breast Carcinoma
Ozben, Volkan; Aydogan, Fatih; Karaca, Fatih Can; Ilvan, Sennur; Uras, Cihan
Summary Background Nodular fasciitis of the breast is a rare benign pathology that can mimic breast cancer clinically, radiologically, and histopathologically. Case Report An 18-year-old female patient had first visited a physician in a different center with the complaint of a lump in her left breast. Breast examination had revealed a palpable mass located in the left upper outer quadrant. Ultrasonography had demonstrated a hypoechoic lesion. Excisional biopsy of the lump had been performed and histopathologic examination misdiagnosed this lump as a mesenchymal tumor. The patient was then referred to our clinic for further investigations. Pathologic revision was performed and the diagnosis of nodular fasciitis of the breast was established. Conclusion Awareness of this rare clinical entity, nodular fasciitis, in the breast eliminates the misdiagnosis of breast cancer. PMID:20877676
Reoperation for angina after previous aortocoronary bypass surgery.
Pidgeon, J; Brooks, N; Magee, P; Pepper, J R; Strurridge, M F; Wright, J E
A retrospective study was carried out of the outcome of 102 patients who underwent a second operation for myocardial revascularisation, necessitated by persistence or recurrence of intractable angina after their first coronary bypass procedures. Operative mortality was 2%. During follow up of the survivors (mean interval 36.4 months) five died, two after further operation, and five underwent further surgery. Sixty eight patients reported an improvement in their symptoms, 57 of whom claimed to have little or no angina. Less favourable results were recorded for those patients reviewed with longer follow up. No useful indicators of prognosis were identified. The problem of angina in patients who have already received bypass grafts is likely to increase as more revascularisation surgery is performed. Reoperation offers a reasonable prospect of helping some of these patients, but not all will be suitable. Their long term prognosis remains uncertain. PMID:3871623
Gamma interferon activates a previously undescribed Ca2+ influx in T lymphocytes from patients with multiple sclerosis.
Martino, G; Clementi, E; Brambilla, E; Moiola, L; Comi, G; Meldolesi, J; Grimaldi, L M
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. The etiology of the disease is still unknown. Activated T lymphocytes are considered essential in mediating the inflammatory process leading to demyelination in MS. They operate through a complex network of cytokines among which gamma interferon (gamma-IFN) plays a key role. Here we report that exposure to gamma-IFN of T lymphocytes from patients with MS activates, by a protein kinase C-mediated pathway, a previously undescribed gamma-IFN-activated Ca2+ influx, functionally coupled to the gamma-IFN receptor. The influx mainly expressed by CD4+ T lymphocytes, was found in 12 of 15 (80%) patients with clinically active MS and in 14 of 30 (46%) patients with stable MS. The influx was found in only 3 of 24 (12%) control patients and in none of the 15 healthy subjects studied. Our results document the appearance in MS lymphocytes of a gamma-IFN-activated, protein kinase C-dependent, Ca2+ influx that might be due to the expression of a new cation-specific plasmalemma channel. This finding suggests that at least part of gamma-IFN's contribution to the pathogenesis of MS is exerted through a Ca(2+)-dependent regulation of T lymphocyte activity. PMID:8197142
A previously undiscovered group of chimpanzees (Pan troglodytes verus) is observed living in the Tonkolili district of Sierra Leone.
Halloran, Andrew R; Cloutier, Christina T; Sesay, Papanie Bai
A previously undocumented group of wild chimpanzees (Pan troglodytes verus) was recently discovered along the Pampana River in the Tonkolili District of Sierra Leone. Based on interviews from local residents (N = 6), we estimate the group size to be approximately 30 individuals. Though this population does not show up in the most recent census of chimpanzees in Sierra Leone, it concurs with findings that indicate most of the chimpanzees in Sierra Leone live scattered throughout the country alongside villages, rather than in protected areas. During a three-week observation in the area, two chimpanzees were hunted and killed. The reason for these deaths, along with other reported instances of hunting in the area, are primarily due to crop-raiding and competition for resources between chimpanzees and humans. We conclude that this is a heavily imperiled population. Based on the ecology of the area and composition of local villages, we propose a number of conservation strategies that will promote a symbiotic relationship between the chimpanzees and human populations residing in the area. PMID:23447116
Hippocampal NMDA receptors and the previous experience effect on memory.
Cercato, MagalĒ C; Colettis, Natalia; Snitcofsky, Marina; Aguirre, Alejandra I; Kornisiuk, Edgar E; Baez, MarĒa V; Jerusalinsky, Diana A
N-methyl-D-aspartate receptors (NMDAR) are thought to be responsible for switching synaptic activity specific patterns into long-term changes in synaptic function and structure, which would support learning and memory. Hippocampal NMDAR blockade impairs memory consolidation in rodents, while NMDAR stimulation improves it. Adult rats that explored twice an open field (OF) before a weak though overthreshold training in inhibitory avoidance (IA), expressed IA long-term memory in spite of the hippocampal administration of MK-801, which currently leads to amnesia. Those processes would involve different NMDARs. The selective blockade of hippocampal GluN2B-containing NMDAR with ifenprodil after training promoted memory in an IA task when the training was weak, suggesting that this receptor negatively modulates consolidation. In vivo, after 1h of an OF exposure-with habituation to the environment-, there was an increase in GluN1 and GluN2A subunits in the rat hippocampus, without significant changes in GluN2B. Coincidentally, in vitro, in both rat hippocampal slices and neuron cultures there was an increase in GluN2A-NMDARs surface expression at 30min; an increase in GluN1 and GluN2A levels at about 1h after LTP induction was also shown. We hypothesize that those changes in NMDAR composition could be involved in the "anti-amnesic effect" of the previous OF. Along certain time interval, an increase in GluN1 and GluN2A would lead to an increase in synaptic NMDARs, facilitating synaptic plasticity and memory; while then, an increase in GluN2A/GluN2B ratio could protect the synapse and the already established plasticity, perhaps saving the specific trace. PMID:25132342
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Breastfeeding Report Card 2014
... this page: About CDC.gov . Breastfeeding Share Compartir Breastfeeding Report Card 2014 Background There are many ways ... Report Card, 2014 - [PDF - 1.25 MB] Previous Breastfeeding Report Cards Breastfeeding Report Card 2013 [1.12 ...
Prediction and accelerated laboratory discovery of previously unknown 18-electron ABX compounds.
Gautier, Romain; Zhang, Xiuwen; Hu, Linhua; Yu, Liping; Lin, Yuyuan; Sunde, Tor O L; Chon, Danbee; Poeppelmeier, Kenneth R; Zunger, Alex
Chemists and material scientists have often focused on the properties of previously reported compounds, but neglect numerous unreported but chemically plausible compounds that could have interesting properties. For example, the 18-valence electron ABX family of compounds features examples of topological insulators, thermoelectrics and piezoelectrics, but only 83 out of 483 of these possible compounds have been made. Using first-principles thermodynamics we examined the theoretical stability of the 400 unreported members and predict that 54 should be stable. Of those previously unreported 'missing' materials now predicted to be stable, 15 were grown in this study; X-ray studies agreed with the predicted crystal structure in all 15 cases. Among the predicted and characterized properties of the missing compounds are potential transparent conductors, thermoelectric materials and topological semimetals. This integrated process-prediction of functionality in unreported compounds followed by laboratory synthesis and characterization-could be a route to the systematic discovery of hitherto missing, realizable functional materials. PMID:25803469
Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia
Byrd, J.C.; Brown, J.R.; OÆBrien, S.; Barrientos, J.C.; Kay, N.E.; Reddy, N.M.; Coutre, S.; Tam, C.S.; Mulligan, S.P.; Jaeger, U.; Devereux, S.; Barr, P.M.; Furman, R.R.; Kipps, T.J.; Cymbalista, F.; Pocock, C.; Thornton, P.; Caligaris-Cappio, F.; Robak, T.; Delgado, J.; Schuster, S.J.; Montillo, M.; Schuh, A.; de Vos, S.; Gill, D.; Bloor, A.; Dearden, C.; Moreno, C.; Jones, J.J.; Chu, A.D.; Fardis, M.; McGreivy, J.; Clow, F.; James, D.F.; Hillmen, P.
Background In patients with chronic lymphoid leukemia (CLL) or small lymphocytic lymphoma (SLL), a short duration of response to therapy or adverse cytogenetic abnormalities are associated with a poor outcome. We evaluated the efficacy of ibrutinib, a covalent inhibitor of BrutonÆs tyrosine kinase, in patients at risk for a poor outcome. Methods In this multicenter, open-label, phase 3 study, we randomly assigned 391 patients with relapsed or refractory CLL or SLL to receive daily ibrutinib or the anti-CD20 antibody ofatumumab. The primary end point was the duration of progression-free survival, with the duration of overall survival and the overall response rate as secondary end points. Results At a median follow-up of 9.4 months, ibrutinib significantly improved progression-free survival; the median duration was not reached in the ibrutinib group (with a rate of progression-free survival of 88% at 6 months), as compared with a median of 8.1 months in the ofatumumab group (hazard ratio for progression or death in the ibrutinib group, 0.22; P<0.001). Ibrutinib also significantly improved overall survival (hazard ratio for death, 0.43; P = 0.005). At 12 months, the overall survival rate was 90% in the ibrutinib group and 81% in the ofatumumab group. The overall response rate was significantly higher in the ibrutinib group than in the ofatumumab group (42.6% vs. 4.1%, P<0.001). An additional 20% of ibrutinib-treated patients had a partial response with lymphocytosis. Similar effects were observed regardless of whether patients had a chromosome 17p13.1 deletion or resistance to purine analogues. The most frequent nonhematologic adverse events were diarrhea, fatigue, pyrexia, and nausea in the ibrutinib group and fatigue, infusion-related reactions, and cough in the ofatumumab group. Conclusions Ibrutinib, as compared with ofatumumab, significantly improved progression-free survival, overall survival, and response rate among patients with previously treated CLL or SLL. (Funded by Pharmacyclics and Janssen; RESONATE ClinicalTrials.gov number, NCT01578707.) PMID:24881631
Ocean acidification due to increasing atmospheric carbon dioxide
Levin, Lisa
Ocean acidification due to increasing atmospheric carbon dioxide Policy document 12/05 June 2005 ISBN 0 85403 617 2 This report can be found at www.royalsoc.ac.uk #12;Ocean acidification firstname.lastname@example.com Copy edited and typeset by The Clyvedon Press Ltd, Cardiff, UK #12;Ocean acidification due
Hepatotoxicity induced by methimazole in a previously healthy patient.
Gallelli, Luca; Staltari, Orietta; Palleria, Caterina; De Sarro, Giovambattista; Ferraro, Maria
We report a case of hepatotoxicity induced by methimazole treatment in a patient affected by hyperthyroidism. A 54-year-old man, presented to our observation for palpitations, excessive sweating, weakness, heat intolerance and weight loss. On physical examination, his blood pressure was 140/90 mmHg and heart beat was 100/min regular. He had mild tremors and left exophthalmos. Laboratory test revealed a significant increase in serum thyroid hormone levels with a decrease in thyroid stimulating hormone levels. A diagnosis of hyperthyroidism was made and he began treatment with methimazole (30 mg/day). Fourteen days later, he returned for the development of scleral icterus, followed by dark urine, and abdominal pain in the right upper quadrant. Laboratory examinations and liver biopsy performed a diagnosis of cholestatic hepatitis, secondary to methimazole usage. Methimazole was promptly withdrawn and cholestyramine, ursodeoxycholic acid, and chlorpheniramine were given. After five days, abdominal pain resolved and laboratory parameters returned to normal. Naranjo probability scale indicated a probable relationship between hepatotoxicity and methimazole therapy. In conclusion physicians should be aware the risk of hepatotoxicity related with methimazole. PMID:19534646
Adenine phosphoribosyltransferase deficiency: a previously undescribed genetic defect in man
Kelley, William N.; Levy, Robert I.; Rosenbloom, Frederick M.; Henderson, J. Frank; Seegmiller, J. Edwin
A deficiency of adenine phosphoribosyltransferase (A-PRTase) is described in four members in three generations of one family. A-PRTase is coded by an autosome and the mutants described in this report are heterozygotes for this enzyme defect. The level of enzyme activity in these heterozygotes was inappropriately low, ranging from 21 to 37% of normal rather than the expected 50% of normal. Examination of various physical and chemical properties of the A-PRTase obtained from the mutant heterozygotes failed to reveal differences from the normal enzyme. These patients have no discernable abnormality in uric acid production despite the finding that patients with a deficiency of a closely related enzyme, hypoxanthine-guanine phosphoribosyltransferase, invariably produce excessive quantities of uric acid. A relationship of the A-PRTase deficiency to the disturbance in lipoprotein metabolism observed in the propositus has not been firmly established. Possible manifestations of the homozygous form of this enzyme deficiency will require identification of such individuals in the future. PMID:5676523
Using previous public testimony to prepare risk messages
Durbin, M.E.
People need a sense of control over their own lives, but they sometimes feel that they do not have that control when faced with a risk such as that posed by a nuclear power reactor or an incinerator for radioactive waste. Agencies communicating the risk must understand the fears of stakeholders (the people who share in the risk) and try to address those fears. The Emergency Response and Community Right to Know Act, Title 3 of the Superfund Amendments and Reauthorization Act (SARA), is a broad risk communication statute that ensures that the information is available through statutes, public hearings, and the media. To arrive at a decision about a risk concerning them and thereby achieve a sense of control, stakeholders must have access to the information about a decision and then must understand it. Their task is seemingly simple: they only have to use their rights under Title 3 to find information on a risk, act on the information, and make an informed choice about the risk. One way that agencies can help the stakeholders maneuver through the maze of regulations governing a risk and communicating the risk itself is through public hearings that actively seek the involvement of the stakeholders. This report suggests items that should be included in the risk message.
Previously diagnosed influenza infections and the risk of developing epilepsy.
Wilson, J C; Toovey, S; Jick, S S; Meier, C R
Several epidemiological studies suggest a possible involvement of viral infection in the development of epilepsy. While recent research from in vitro studies increasingly supports the role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of epilepsy, little is known about the role of other viral infections such as influenza. Using data from the Clinical Practice Research Datalink (CPRD), we conducted a matched case-control analysis to assess the association between GP-diagnosed influenza infections and the risk of developing an incident diagnosis of epilepsy. During the study period 11 244 incident epilepsy cases and 44 976 matched control patients were identified. Prior exposure to influenza was reported in 7Ę5% of epilepsy cases and 6Ę7% of controls [adjusted odds ratio (aOR) 1Ę12, 95% confidence interval (CI) 1Ę03-1Ę22]. Prior history of 'complicated influenza', i.e. influenza associated with a possible super-infection, was associated with a slightly increased epilepsy risk (aOR 1Ę64, 95% CI 1Ę10-2Ę46), particularly if recorded within the 2 months preceding the epilepsy diagnosis (aOR 6Ę03, 95% CI 1Ę10-33Ę2). Our findings suggest that prior influenza exposure does not appear to materially alter the risk of developing epilepsy. By contrast, influenza episodes accompanied by complications were associated with a slightly increased epilepsy risk. PMID:25519212
Effect of previous chloroquine intake on in vivo P. falciparum drug sensitivity.
Bayoumi, R A; Dar, F K; Tanira, M O; Stephen, R S; Hussein, M M; Hammo, N E; Omer, R I; Beidas, M F; Shalabi, A; el-Wasila, M
Investigation of the in vivo response of P. falciparum malaria parasites to chloroquine was conducted during 1993/94 in Al-Ain District of Abu Dhabi Emirate, UAE. Sixty seven expatriates who developed falciparum malaria on their return from Pakistan, Oman and Sudan were recruited for the WHO in vivo tests. Of the 67 patients, eight were classified as having RII and RIII responses, while 59 remained aparasitaemic at the end of the seven-day WHO standard test. On continuation into the 28-day WHO extended test, a further 34 patients exhibited RI resistance. Resistance of parasites to chloroquine was confirmed by measurement of plasma chloroquine using High-Performance Liquid Chromatography. In all 67 patients, the level of chloroquine was well above the minimum therapeutic level. The outcome of the in vivo test in patients treated for the first time was significantly different from that in patients who were previously on chloroquine. Among patients treated for the first time, 36 out of 41 (88%) had a resistant response, whereas, among those previously on chloroquine only six out of 26 (23%) had a resistant response. The difference is probably due to the higher initial plasma level of chloroquine among patients who were previously on the drug. Curing more patients with higher plasma chloroquine implies that chloroquine shall continue to be useful, particularly if resistance is at the RI level. Appropriate higher therapeutic levels of chloroquine should be defined for such patients. PMID:9337002
Technology Transfer Automated Retrieval System (TEKTRAN)
This study was undertaken to measure the potential for broiler carcass contamination with Campylobacter due to exposure of live birds to a contaminated dump cage. Broilers were obtained from commercial grow-out houses that had been previously identified as either Campylobacter positive or negative...
The identity of the previous visitor influences flower rejection by nectar-collecting bees.
In the field, recently probed flowers of borage, Borago officinalis, typically contained little or no nectar (and hence were relatively unrewarding), whether probed by a bumblebee, Bombus spp., worker or a honeybee, Apis mellifera. However, a nectar-collecting bee was likely to reject a recently probed flower only if the previous visitor was a conspecific (honeybees) or congener (bumblebees); the effect was especially marked in honeybees. Honeybees rejected more than 80% of flowers probed by conspecifics less than 20 s previously, but less than 20% of flowers probed by bumblebees less than 20 s previously. Only if the previous bee was a conspecific or congener did the probability of a bee probing a flower increase with the time since the last probing visit. Otherwise, the probability of a bee probing was independent of the time elapsed since the last visit. Bees' reactions to flowers whose nectar content had been manipulated independently of prior visits suggested that bees were repelled from flowers by species- or genus-specific chemical cues deposited by previous bees. Laboratory studies elsewhere have reported that honeybees are repelled from artificial feeders by volatile bee-deposited chemicals. My results constitute strong evidence that such cues are used by nectar-collecting honeybees in the field, and also suggest that bumblebees respond to similar cues. Calculations show that the ability to detect recently visited flowers may help bees to make a foraging profit, especially when bee densities are high. Thus, bee-deposited chemicals may confer information and economic advantages to foraging alongside conspecifics or congeners. Copyright 1998 The Association for the Study of Animal Behaviour. PMID:9784216
A case of severe anal injury in an adolescent male due to bestial sexual experimentation.
Blevins, Roger O
This report delineates a case of anal injury in a 12-year-old boy who gave a detailed history of bestial behavior with a male bulldog. The child described how he had seen this behavior modeled on the internet and subsequently initiated contact with his own dog, causing the dog to penetrate him anally. This type of juvenile bestial behavior with injury has only been reported once previously in the medical literature. Zoophilia, along with a number of other paraphilias, frequently has its onset in the adolescent age group. Adolescents evidencing paraphilic behaviors require thorough psychological evaluation. Spontaneous sexual assault of a human by a canine has never been described in the human or veterinary medical literature, nor is such a thing likely. A clinician involved in evaluating serious ano-genital injury in a child reportedly due to spontaneous canine sexual assault must consider other possible traumatic etiologies including sexual abuse. Investigation in any such case is essential. PMID:19733331
Delayed vaginal reconstruction in the fibrotic pelvis following radiation or previous reconstruction
Berek, J.S.; Hacker, N.F.; Lagasse, L.D.; Smith, M.L.
Vaginal reconstruction was performed in 14 patients who had developed vaginal stenosis secondary to extensive pelvic fibrosis after pelvic radiation therapy (12 patients) or prior vaginal reconstruction (2 patients). Sixteen procedures were performed using a split-thickness skin graft. All patients had satisfactory vaginal restoration, and 12 patients reported good vaginal function. No fistula developed as a result of the operative procedure, but one patient later developed a rectovaginal fistula resulting from tumor recurrence. Successful vaginal reconstruction can be achieved even years after initial therapy in patients who develop an obliterated vagina from previous radiation or surgery.
Surgical Site Infection due to a Preauricular Sinus: A Rare Complication after Craniotomy
Anda, Takeo; Mori, Hiroshi
Summary: Wound infection due to a preauricular sinus after craniotomy has not been previously reported. A 71-year-old woman visited our institute with subarachnoid hemorrhage. The aneurysm was surgically clipped with external decompression. Sixteen days after surgery, a focal erythema and discharging were observed at the inferior end of the skin incision. Careful inspection revealed a small pit there, which was diagnosed as a preauricular sinus. After the infection subsided, the sinus was completely excised. Neurosurgeons must be aware of this rare condition and must opt for complete excision to prevent infectious sequelae even if the preauricular sinus is asymptomatic. PMID:25426340
Milky Way Past Was More Turbulent Than Previously Known
NASA Astrophysics Data System (ADS)
Results of 1001 observing nights shed new light on our Galaxy [1] Summary A team of astronomers from Denmark, Switzerland and Sweden [2] has achieved a major breakthrough in our understanding of the Milky Way, the galaxy in which we live. After more than 1,000 nights of observations spread over 15 years, they have determined the spatial motions of more than 14,000 solar-like stars residing in the neighbourhood of the Sun. For the first time, the changing dynamics of the Milky Way since its birth can now be studied in detail and with a stellar sample sufficiently large to allow a sound analysis. The astronomers find that our home galaxy has led a much more turbulent and chaotic life than previously assumed. PR Photo 10a/04: Distribution on the sky of the observed stars. PR Photo 10b/04: Stars in the solar neigbourhood and the Milky Way galaxy (artist's view). PR Video Clip 04/04: The motions of the observed stars during the past 250 million years. Unknown history Home is the place we know best. But not so in the Milky Way - the galaxy in which we live. Our knowledge of our nearest stellar neighbours has long been seriously incomplete and - worse - skewed by prejudice concerning their behaviour. Stars were generally selected for observation because they were thought to be "interesting" in some sense, not because they were typical. This has resulted in a biased view of the evolution of our Galaxy. The Milky Way started out just after the Big Bang as one or more diffuse blobs of gas of almost pure hydrogen and helium. With time, it assembled into the flattened spiral galaxy which we inhabit today. Meanwhile, generation after generation of stars were formed, including our Sun some 4,700 million years ago. But how did all this really happen? Was it a rapid process? Was it violent or calm? When were all the heavier elements formed? How did the Milky Way change its composition and shape with time? Answers to these and many other questions are 'hot' topics for the astronomers who study the birth and evolution of the Milky Way and other galaxies. Now the rich results of a 15 year-long marathon survey by a Danish-Swiss-Swedish research team [2] are providing some of the answers. 1,001 nights at the telescopes ESO PR Photo 10a/04 ESO PR Photo 10a/04 Sky distribution of the observed stars [Preview - JPEG: 518 x 400 pix - 96k] [Normal - JPEG: 1035 x 800 pix - 897k] Caption: ESO PR Photo 10a/04 shows the distribution on the sky of the approx. 14,000 observed stars. The region on the left that is denser than its surroundings is the nearby Hyades star cluster. The team spent more than 1,000 observing nights over 15 years at the Danish 1.5-m telescope of the European Southern Observatory at La Silla (Chile) and at the Swiss 1-m telescope of the Observatoire de Haute-Provence (France). Additional observations were made at the Harvard-Smithsonian Center for Astrophysics in the USA. A total of more than 14,000 solar-like stars (so-called F- and G-type stars) were observed at an average of four times each - a total of no less than 63,000 individual spectroscopic observations! This now complete census of neighbourhood stars provides distances, ages, chemical analysis, space velocities and orbits in the general rotation of the Milky Way. It also identifies those stars (about 1/3 of them all) which the astronomers found to be double or multiple. This very complete data set for the stars in the solar neighbourhood will provide food for thought by astronomers for years to come. A dream come true ESO PR Photo 10b/04 ESO PR Photo 10b/04 Stars in the solar neighbourhood [Preview - JPEG: 459 x 400 pix - 29k] [Normal - JPEG: 918 x 800 pix - 441k] [FullRes - JPEG: 3000 x 2613 pix - 4.4Mb] Caption: ESO PR Photo 10b/04 provides an artist's view of the observed group of stars orbiting the Milky Way together with the Sun, as seen by an imaginary observer outside the Galaxy. The orbit of the Sun is shown. For clarity, the stars surrounding the local volume have been removed here. These observations provide the long-sought missing pieces of the puzz
Temperament dimensions and posttraumatic stress symptoms in a previously deployed military sample.
Escolas, Sandra M; Escolas, Holliel D
This study examines the effects of temperament on self-reported posttraumatic stress disorder (PTSD) symptoms from a convenience sample of US military service members (N=559). Previously deployed active duty service members completed anonymous questionnaires that included demographics, temperament, and PTSD measures. This study also examines demographic variables such as age, gender, ethnicity, race, education, and marital status, and service-related variables such as branch, grade, and years of military service for moderating effects. Results suggest a relationship between the temperament dimensions and PTSD symptoms in that the temperament dimensions of low mood quality, high levels of activity generally and during sleep, and low flexibility were found to predict high levels of self-reported PTSD symptoms. This is the first study incorporating temperament as a predictor of PTSD within a military population and provides the basis for future research in this area. PMID:25651150
Radiation damage due to electromagnetic showers
Rakhno, Igor; Mokhov, Nikolai; Striganov, Sergei; /Fermilab
Radiation-induced damage due to atomic displacements is essential to correctly predict the behavior of materials in nuclear reactors and at charged-particle accelerators. Traditionally the damage due to hadrons was of major interest. The recent increased interest in high-energy lepton colliders gave rise to the problem of prediction of radiation damage due to electromagnetic showers in a wide energy range--from a few hundred keV and up to a few hundred GeV. The report describes results of an electron- and positron-induced displacement cross section evaluation. It is based on detailed lepton-nucleus cross sections, realistic nuclear form-factors and a modified Kinchin-Pease damage model. Numerical data on displacement cross sections for various target nuclei is presented.
Acute abdomen due to small bowel anisakiasis.
Pellegrini, M; Occhini, R; Tordini, G; Vindigni, C; Russo, S; Marzocca, G
The popularity in Western countries of dishes based on raw fish has led to an increased incidence of anisakiasis, a human parasitic disease caused by the ingestion of live anisakid larvae. The entire digestive tract may be involved, but the stomach and the small intestine are the most frequently affected sites. We report a case of acute abdomen due to Anisakis simplex infection that caused small bowel obstruction. PMID:15702863
Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium
Brenner, Darren R.; Boffetta, Paolo; Duell, Eric J.; Bickeb÷ller, Heike; Rosenberger, Albert; McCormack, Valerie; Muscat, Joshua E.; Yang, Ping; Wichmann, H.-Erich; Brueske-Hohlfeld, Irene; Schwartz, Ann G.; Cote, Michele L.; Tj°nneland, Anne; Friis, S°ren; Le Marchand, Loic; Zhang, Zuo-Feng; Morgenstern, Hal; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Zaridze, David; Rudnai, Peter; Fabianova, Eleonora; Foretova, Lenka; Janout, Vladimir; Bencko, Vladimir; Schejbalova, Miriam; Brennan, Paul; Mates, Ioan N.; Lazarus, Philip; Field, John K.; Raji, Olaide; McLaughlin, John R.; Liu, Geoffrey; Wiencke, John; Neri, Monica; Ugolini, Donatella; Andrew, Angeline S.; Lan, Qing; Hu, Wei; Orlow, Irene; Park, Bernard J.; Hung, Rayjean J.
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984¢2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk. PMID:22986146
Sentinel lymph node biopsy in breast cancer patients with previous breast augmentation surgery.
Nagao, Tomoya; Hojo, Takashi; Kurihara, Hiroaki; Tsuda, Hitoshi; Tanaka-Akashi, Sadako; Kinoshita, Takayuki
The number of breast augmentation surgeries (BAS) has increased. Therefore, the number of breast cancer patients with history of BAS has also increased. In this paper, we present two cases of sentinel lymph node biopsy (SLNB) in patients with previous BAS who were diagnosed with breast cancer. The patients were augmented using different approach; the first case was augmented through transaxillary incision, whereas the second case was augmented through periareolar incision. Lymphoscintigraphy (LPG) was performed on the patients 1Āday prior to operation, enabling confirmation of lymphatic flow and SLN in both patients. SLNB was successfully performed in both cases. In one patient, SLNB was performed using indocyanine green (ICG) fluorescence and the Photodynamic Eye (PDE) system. Regardless of history of BAS, ICG and PDE system showed lymphatic flow and SLN in real time. LPG and ICG fluorescence were useful methods for SLN detection in patients with previous BAS, being able to confirm lymph flow before operation. Biopsy methods using LPG and PDE system were considered useful for difficult confirmation of lymph flow after breast augmentation. This is the first report of SLNB using ICG and PDE system for patients with previous BAS. PMID:21671037
[Air-dispersed asbestos fiber pollution in urban areas: current and previous levels].
Massola, A
Over the last twelve years (since the Lombard Regional Law n 41 on asbestos came out in 1986) I have had the opportunity to actively take part into monitoring campaigns both in working environments and in several urban areas. At the beginning analysis were performed almost exclusevely using phase contrast optical microscope (MOCF). This technique, even with its well known limits, has lead to measurments of asbestos pollution never exceeding 4-5 fibers L(-1) in urban areas. The reported value had lowered to 1-2 fibers L(-1) by the beginning of the nineties and, in the following years it has become even lower. The introduction of scanning electronic microscope (SEM) has not only confirmed these data but also shown lowered values of asbestos fibers in air (< 0.05 fibers L(-1)). This is to be related with the use of artificial fibers (glass and synthetical fibers) in cars braking systems instead of natural mineralfibers (asbestos). Nowadays the concrete-asbestos roof coverages can be a potential environmental pollution source if their surfaces are not protected. The reported indoor levels of pollution are similar to the outdoor ones and to levels reported in areas nearby rock-caves. The levels of asbestos pollution reported in the previous years using MOCF have been nowadays confirmed using SEM, expecially as far as buildings reclaimed from asbestos are concerned. PMID:16512341
Rhabdomyosarcoma Arising in a Previously Irradiated Field: An Analysis of 43 Patients
Dang, Nguyen D. [Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas (United States)] [Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas (United States); Teh, Bin S. [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States)] [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States); Paulino, Arnold C., E-mail: firstname.lastname@example.com [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States)
Patients with soft tissue sarcomas that arise from previously irradiated fields have traditionally been reported to have a poor prognosis. In this report, we examined the characteristics and outcomes of patients who developed a rhabdomyosarcoma in a previously irradiated field (RMS-RIF); we hypothesize that these patients should have a better outcome compared to other postradiation soft tissue sarcomas as these tumors are chemosensitive and radiosensitive. A PubMed search of the literature from 1961-2010 yielded 33 studies with data for patients with RMS-RIF. The study included 43 patients with a median age of 6.5 years at the time of radiation therapy (RT) for the initial tumor. The median RT dose was 48 Gy. The median latency period, the time from RT to development of RMS-RIF, was 8 years. The 3-year overall survival for RMS-RIF was 42%. The 3-year overall survival was 66% for patients receiving chemotherapy and local treatment (surgery and/or RT) compared to 29% for those who had systemic treatment only or local treatment only (P=.049). Other factors associated with increased 3-year overall survival included retinoblastoma initial diagnosis (P<.001), age ?18 years at diagnosis of RMS-RIF (P=.003), favorable site (P=.008), and stage 1 disease (P=.002). Age at time of RMS-RIF, retinoblastoma initial tumor, favorable site, stage 1 disease, and use of both systemic and local treatment were found to be favorable prognostic factors for 3-year overall survival.
1. Introduction The work described in this report continues similar work described in a previous report [3]. That
Mills, David L.
of projects useful in laboratory courses for upper division computer engineering and digital communications the ionosphere, which acts as an unreliable, multiple reflector, and that the noise process is very bursty. Thus transitions corresponding to a conventional time-of-century clock and the probabilities of received decimal
1. Introduction The work described in this report continues similar work described in a previous report [3]. That
Mills, David L.
of projects useful in laboratory courses for upper division computer engineering and digital communications the ionosphere, which acts as an unreliable, multiple reflector, and that the noise process is very bursty. Thus transitions corresponding to a conventional timeŁofŁcentury clock and the probabilities of received decimal
Announcement due to MSVE Department
Announcement due to MSVE Department 2 weeks prior to defense Student revises Thesis GPD Announcement due to MSVE Department 2 weeks prior to defense Student revises Dissertation GPD revises's Office by appropriate deadline for binding Student graduates! Master's Thesis Completion Process
Phase 1/2 study of ocaratuzumab, an Fc-engineered humanized anti-CD20 monoclonal antibody, in low-affinity Fc?RIIIa patients with previously treated follicular lymphoma.
Ganjoo, Kristen N; de Vos, Sven; Pohlman, Brad L; Flinn, Ian W; Forero-Torres, Andres; Enas, Nathan H; Cronier, Damien M; Dang, Nam H; Foon, Kenneth A; Carpenter, Susan P; Slapak, Christopher A; Link, Brian K; Smith, Mitchell R; Mapara, Markus Y; Wooldridge, James E
This phase 2 study assessed the safety and efficacy of ocaratuzumab, a humanized anti-CD20 monoclonal antibody. Fifty patients with previously treated follicular lymphoma (FL) and a low-affinity genotype of Fc?RIIIa received ocaratuzumab 375 mg/m(2) weekly for 4 weeks. Grade 3/4/5 adverse events (AEs) were reported in 11/1/1 patients, respectively. Serious AEs were reported by 11/50 patients, and three discontinued due to AEs. One patient died from aspiration pneumonia due to possibly drug-related nausea and vomiting. Investigator-assessed response rate was 30% (15/50), including four complete responses (CR), three CR unconfirmed (CRu) and eight partial responses (PR). Investigator-assessed median Progression-free survivial (PFS) was 38.3 weeks. Ocaratuzumab's pharmacokinetic profile was similar to that reported for rituximab. Lymphocyte subset analysis showed significant, selective reduction of B-cells during and after ocaratuzumab treatment. Ocaratuzumab at this dose and schedule is active and well tolerated in patients with previously treated FL with low affinity Fc?RIIIa genotypes. ClinTrials registry number: NCT00354926. PMID:24717109
This report forms the basis for a feasibility study and conceptual design to control vapor emissions from waste storage tanks at the Hanford Site. The Carbtrol, Vapor Mixing, and High Efficiency Gas Absorber (HEGA) vapor controls were evaluated to determine the lessons learned from previous failed vapor control attempts. This document illustrates the resulting findings based on that evaluation.
Two flavanone compounds from litchi ( Litchi chinensis Sonn.) seeds, one previously unreported, and appraisal of their ?-glucosidase inhibitory activities
Shen Ren; Duoduo Xu; Zhi Pan; Yang Gao; Zhenguo Jiang; Qipin Gao
Using a bioactivity-guided method, a new and a previously reported flavanone glycoside were isolated from 50% ethanol extract of litchi (Litchi chinensis Sonn.) seeds. Column chromatography using macroporous resin, silica gel and Sephadex LH-20 was applied during the isolation, and the method of PMP derivatisation was performed to investigate the component sugar of the compounds. The structures of the compounds
Whole-Genome Sequence and Annotation of Octopine-Utilizing Pseudomonas kilonensis (Previously P.Āfluorescens) Strain 1855-344.
Eng, Wilhelm Wei Han; Gan, Han Ming; Gan, Huan You; Hudson, Andrķ O; Savka, Michael A
Here, we report the whole-genome sequence and annotation of Pseudomonas kilonensis 1855-344 (previously known as P. fluorescens 1855-344). The genome contains an octopine oxidase gene cluster consistent with the ability to utilize octopine. A biosynthetic gene cluster was identified for mangotoxin and aryl-polyene using the antiSMASH server. PMID:25977435
Contact urticaria due to phenoxyethanol in an aftershave.
Lujan, Dunia; Hernandez-Machin, Buenaventura; Pe±ate, Yeray; Borrego, Leopoldo
The occurrence of pruritus immediately after application of an aftershave product is usually due to irritant contact dermatitis. We report a case of contact urticaria in a male patient, produced by an aftershave product containing phenoxyethanol. PMID:19804693
[Hypothermia due to anti-tuberculosis drugs: first case].
Oualil, H; Nejjari, S; Bourkadi, J E; Iraqi, G
HypothermiaĀ-Āan adverse reaction of drug use potentially severeĀ-Ārequires an early diagnosis and an adapted management. We report the first case, to our knowledge of hypothermia due to anti-tuberculosis drugs. PMID:24646781
Prenatal diagnosis and post-mortem examination in a fetus with thrombocytopenia-absent radius (TAR) syndrome due to compound heterozygosity for a 1q21.1 microdeletion and a RBM8A hypomorphic allele: a case report
Background Thrombocytopenia¢absent radius syndrome is a rare autosomal recessive disorder characterized by megakaryocytic thrombocytopenia and longitudinal limb deficiencies mostly affecting the radial ray. Most patients are compound heterozygotes for a 200 kb interstitial microdeletion in 1q21.1 and a hypomorphic allele in RBM8A, mapping in the deleted segment. At the moment, the complete molecular characterization of thrombocytopenia¢absent radius syndrome is limited to a handful of patients mostly ascertained in the pediatric age Case presentation We report on a fetus with bilateral upper limb deficiency found at standard prenatal ultrasound examination. The fetus had bilateral radial agenesis and humeral hypo/aplasia with intact thumbs, micrognathia and urinary anomalies, indicating thrombocytopenia¢absent radius syndrome. Molecular studies demonstrated compound heterozygosity for the 1q21.1 microdeletion and the RBM8A rs139428292 variant at the hemizygous state, inherited from the mother and father, respectively Conclusion The molecular information allowed prenatal diagnosis in the following pregnancy resulting in the birth of a healthy carrier female. A review was carried out with the attempt to the trace the fetal ultrasound presentation of thrombocytopenia¢absent radius syndrome and discussing opportunities for second-tier molecular studies within a multidisciplinary setting. PMID:24053387
48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.
Code of Federal Regulations, 2013 CFR
...2013-10-01 false Technical data or computer software previously delivered to the... 252.227-7028 Technical data or computer software previously delivered to the...following provision: Technical Data or Computer Software Previously Delivered to...
48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.
Code of Federal Regulations, 2012 CFR
...2012-10-01 false Technical data or computer software previously delivered to the... 252.227-7028 Technical data or computer software previously delivered to the...following provision: Technical Data or Computer Software Previously Delivered to...
48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.
Code of Federal Regulations, 2014 CFR
...2014-10-01 false Technical data or computer software previously delivered to the... 252.227-7028 Technical data or computer software previously delivered to the...following provision: Technical Data or Computer Software Previously Delivered to...
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types
Merkle, Florian T.; Fuentealba, Luis C.; Sanders, Timothy A.; Magno, Lorenza; Kessaris, Nicoletta; Alvarez-Buylla, Arturo
Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb (OB). The full extent of diversity among adult NSCs and their progeny is not known. Here, we report the generation of at least four previously unknown OB interneuron subtypes that are produced in finely patterned progenitor domains in the anterior ventral V-SVZ of both the neonatal and adult brain. Progenitors of these novel interneurons are responsive to sonic hedgehog (SHH) and are organized into microdomains that correlate with the expression domains of the Nkx6.2 and Zic family of transcription factors. This work reveals an unexpected degree of complexity in the specification and patterning of NSCs in the postnatal mouse brain. PMID:24362763
Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survival
Wu, Qingmin; Pei, Jianwu; Turse, Carol; Ficht, Thomas A
Background Random gene inactivation used to identify cellular functions associated with virulence and survival of Brucella spp has relied heavily upon the use of the transposon Tn5 that integrates at G/C base pairs. Transposons of the mariner family do not require species-specific host factors for efficient transposition, integrate nonspecifically at T/A base pairs, and, at a minimum, provide an alternative approach for gene discovery. In this study, plasmid vector pSC189, containing both the hyperactive transposase C9 and transposon terminal inverted repeats flanking a kanamycin resistance gene, were used to deliver Himar1 transposable element into the B. melitensis genome. Conjugation was performed efficiently and rapidly in less than one generation in order to minimize the formation of siblings while assuring the highest level of genome coverage. Results Although previously identified groups or classes of genes required for virulence and survival were represented in the screen, additional novel identifications were revealed and may be attributable to the difference in insertion sequence biases of the two transposons. Mutants identified using a fluorescence-based macrophage screen were further evaluated using gentamicin-based protection assay in macrophages, survival in the mouse splenic clearance model and growth in vitro to identify mutants with reduced growth rates. Conclusion The identification of novel genes within previously described groups was expected, and nearly two-thirds of the 95 genes had not been previously reported as contributing to survival and virulence using random Tn5-based mutagenesis. The results of this work provide added insight with regard to the regulatory elements, nutritional demands and mechanisms required for efficient intracellular growth and survival of the organism. PMID:17176467
Impacts of Current and Previous Land Use on Greenhouse Gas Fluxes for Biofuel Cropping Systems
NASA Astrophysics Data System (ADS)
Del Grosso, S.; Parton, W.; Adler, P.; Ogle, S.; West, T.
Biofuel cropping systems are both a source and sink of greenhouse gases (GHG). Fertilizer and pesticide manufacture and transport, farm machinery operation, and processing of biomass into fuel all lead to carbon dioxide (CO2) emissions, but the largest GHG sources for biofuel systems are often soil nitrous oxide (N2O) emissions and loss of organic carbon as a result of land use change. However, improved land management can increase soil carbon levels and decrease N2O emissions, thus complementing the CO2 sink from displaced fossil fuel combustion. Previously cropped land, grazed land, and Conservation Reserve Program (CRP) land is being converted to biofuel cropping. We report results for the central US because most of the land used for biofuel cropping is in the central region of the country (corn/soy belt). The primary tool for this analysis is the DAYCENT ecosystem model. The ability of the model to simulate soil GHG fluxes and crop yields is demonstrated and results from simulations of different land management scenarios are presented. Our analyses suggest that conversion of CRP or grazed land to corn ethanol cropping under conventional management leads to a net source of GHG, but that converting these lands to perennial cellulosic biofuel cropping results in a GHG sink. Previously cropped land converted to corn ethanol under conventional management is a small GHG sink, but improved management and conversion to cellulosic based crops can greatly increase this sink strength.
The impact of detecting bipolar disorder in previously diagnosed unipolar patients at a specialist depression clinic.
Parker, Gordon; Fletcher, Kathryn; Barrett, Melissa; Synnott, Howe; Breakspear, Michael; Rees, Anne-Marie; Blanch, Bianca
This study aimed to examine the short-term clinical impact of identifying bipolar disorder in patients previously managed as having a unipolar disorder. The study was incorporated within a consecutive sample of 1000 patients attending a specialist depression clinic for diagnostic and management considerations. Of those assessed, 34% were evaluated as having a bipolar disorder, with this condition having been diagnosed for the first time in three-quarters of those patients. We reviewed sample members 12 weeks later and compared the courses of the "newly diagnosed" and "established" bipolar subsets. Some four-fifths of the bipolar patients reported a degree of improvement, whereas there were no clear differences between the two bipolar subsets. The nondifferential outcome of the bipolar (previously and newly diagnosed) subsets could suggest that there were nonspecific benefits of assessment or that the management was optimized for both groups. Future studies examining the impact of diagnosing a bipolar disorder would therefore benefit from the close consideration of the optimal control group or control strategy. PMID:21629023
A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer
Xu, Jingxiong; Werdyani, Salem; Shestopaloff, Konstantin; Dicks, Elizabeth; Green, Jane; Parfrey, Patrick; Green, Roger
Several published studies identified associations of a number of polymorphisms with a variety of survival outcomes in colorectal cancer. In this study, we aimed to explore 102 previously reported common genetic polymorphisms and their associations with overall survival (OS) and disease-free survival (DFS) in a colorectal cancer patient cohort from Newfoundland (n = 505). Genotypes were obtained using a genomewide SNP genotyping platform. For each polymorphism, the best possible genetic model was estimated for both overall survival and disease-free survival using a previously published approach. These SNPs were then analyzed under their genetic models by Cox regression method. Correction for multiple comparisons was performed by the False Discovery Rate (FDR) method. Univariate analysis results showed that RRM1-rs12806698, IFNGR1-rs1327474, DDX20-rs197412, and PTGS2-rs5275 polymorphisms were nominally associated with OS or DFS (p < 0.01). In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected. However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes. We conclude that polymorphisms investigated in this study are not associated with OS or DFS in our colorectal cancer patient cohort. PMID:26064972
High prevalence of genetic variants previously associated with Brugada syndrome in new exome data.
Risgaard, B; Jabbari, R; Refsgaard, L; Holst, A G; Hauns°, S; Sadjadieh, A; Winkel, B G; Olesen, M S; Tfelt-Hansen, J
More than 300 variants in 12 genes have been associated with Brugada syndrome (BrS) which has a prevalence ranging between 1:2000 and 1:100,000. Until recently, there has been little knowledge regarding the distribution of genetic variations in the general population. This problem was partly solved, when exome data from the NHLI GO Exome Sequencing Project (ESP) was published. In this study, we aimed to report the prevalence of previously BrS-associated variants in the ESP population. We performed a search in ESP for variants previously associated with BrS. In addition, four variants in ESP were genotyped in a second Danish control population (n?=?536) with available electrocardiograms. In ESP, we identified 38 of 355 (10%) variants, distributed on 272 heterozygote carriers and two homozygote carriers. The genes investigated were on average screened in 6258 individuals. This corresponds to a surprisingly high genotype prevalence of 1:23 (274:6258). Genotyping the four common ESP-derived variants CACNA2D1 S709N, SCN5A F2004L, CACNB2 S143F, and CACNB2 T450I in the Danish controls, we found a genotype prevalence comparable with that found in ESP. We suggest that exome data are used in research, as an additive tool to predict the pathogenicity of variants in patients suspected for BrS. PMID:23414114
Previously unrecognized ornithuromorph bird diversity in the Early Cretaceous Changma Basin, Gansu Province, northwestern China.
Wang, Ya-Ming; O'Connor, Jingmai K; Li, Da-Qing; You, Hai-Lu
Here we report on three new species of ornithuromorph birds from the Lower Cretaceous Xiagou Formation in the Changma Basin of Gansu Province, northwestern China: Yumenornis huangi gen. et sp. nov., Changmaornis houi gen. et sp. nov., and Jiuquanornis niui gen. et sp. nov.. The last of these is based on a previously published but unnamed specimen: GSGM-05-CM-021. Although incomplete, the specimens can be clearly distinguished from each other and from Gansus yumenensis Hou and Liu, 1984. Phylogenetic analysis resolves the three new taxa as basal ornithuromorphs. This study reveals previously unrecognized ornithuromorph diversity in the Changma avifauna, which is largely dominated by Gansus but with at least three other ornithuromorphs. Body mass estimates demonstrate that enantiornithines were much smaller than ornithuromorphs in the Changma avifauna. In addition, Changma enantiornithines preserve long and recurved pedal unguals, suggesting an arboreal lifestyle; in contrast, Changma ornithuromorphs tend to show terrestrial or even aquatic adaptions. Similar differences in body mass and ecology are also observed in the Jehol avifauna in northeastern China, suggesting niche partitioning between these two clades developed early in their evolutionary history. PMID:24147058
Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy
Zeng, R; Coates, JR; Johnson, GC; Hansen, L; Awano, T; Kolicheski, A; Ivansson, E; Perloski, M; Lindblad-Toh, K; O'Brien, DP; Guo, J; Katz, ML; Johnson, GS
Background Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. Objective To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. Animals DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. Methods Retrospective analysis of 35,359 previously determined genotypes at SOD1:c.118G>A or SOD1:c.52A>T and prospective survey to update the clinical status of a subset of dogs from which samples were obtained with a relatively low ascertainment bias. Results The SOD1:c.118A allele was found in cross-bred dogs and in 124 different canine breeds whereas the SOD1:c.52T allele was only found in Bernese Mountain Dogs. Most of the dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A homozygotes, but 8 dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A/G heterozygotes and had no other sequence variants in their SOD1 amino acid coding regions. The updated clinical conditions of dogs from which samples were obtained with a relatively low ascertainment bias suggest that SOD1:c.118A homozygotes are at a much higher risk of developing degenerative myelopathy than are SOD1:c.118A/G heterozygotes. Conclusions and Clinical Importance We conclude that the SOD1:c.118A allele is widespread and common among privately owned dogs whereas the SOD1:c.52T allele is rare and appears to be limited to Bernese Mountain Dogs. We also conclude that breeding to avoid the production of SOD1:c.118A homozygotes is a rational strategy. PMID:24524809
Neuropsychological function in retired workers with previous long-term occupational exposure to solvents
Daniell, W. E.; Claypoole, K. H.; Checkoway, H.; Smith-Weller, T.; Dager, S. R.; Townes, B. D.; Rosenstock, L.
OBJECTIVES: It is plausible that neurodegenerative processes of aging might have a contributing role in the development of chronic effects of exposure to organic solvents. This study evaluated the risk for neuropsychological deficits among retired workers, relative to their histories of exposure to occupational solvents. METHODS: This cross sectional study evaluated retired male workers, 62-74 years of age, including 89 people with previous long-term occupational exposure to solvents (67 retired painters and 22 retired aerospace manufacturing workers), and 126 retired carpenters with relatively minimal previous exposure to solvents. Subjects completed a standardised neuropsychological evaluation and psychiatric interview, structured interviews for histories of occupational exposure and alcohol consumption, and questionnaires assessing neurological and depressive symptoms. RESULTS: By comparison with the carpenters, the painters on average reported greater cumulative alcohol consumption and had lower scores on the WAIS-R vocabulary subtest, usually presumed to reflect premorbid intellectual functioning. These findings, however, were not sufficient to account for the other study findings. Controlling for age, education, vocabulary score, and alcohol use, the painters had lower mean scores on test measures of motor, memory, and reasoning ability; and a subgroup of aerospace workers with moderate to high cumulative exposure to solvents (n = 8) had lower mean scores on measures of visuomotor speed, and motor, attention, memory, and reasoning ability. Subjects were more likely to have an increased number of relatively abnormal test scores (three or more outlier scores on 17 test measures) among both the painter group (odds ratio (OR), 3.1; 95% confidence interval (95% CI) 1.5 to 6.2) and the subgroup of aerospace workers with higher cumulative exposure (OR 5.6; 95% CI 1.0 to 38). The painters, but not the aerospace workers, reported significantly more neurological and depressive symptoms. CONCLUSIONS: The findings are consistent with residual central nervous system dysfunction from long-term exposure to organic solvents, persisting years after the end of exposure. Ā PMID:10448313
Tracheobronchial injury due to blunt chest trauma
Mahmodlou, Rahim; Sepehrvand, Nariman
Tracheobronchial avulsion resulting from blunt trauma is a very rare and serious condition, mostly due to high-speed traffic crashes. In this article, we briefly report the case of an 18-year-old man who was injured in a car accident and because of massive persistent air leakage (despite appropriate chest tube drainage), deemed to have a deep tracheobronchial injury. Due to a rapid drop in the patient's O2 saturation, he underwent an anterolateral thoracotomy. Endotracheal intubation was performed under direct visualization. The right mainstem bronchus was disrupted from the carina with a 1.5-cm stump remaining on the carina, and the remainder was crushed to the origin of the right superior lobe bronchus. Hence, a right superior lobectomy was performed and the postoperative course was uneventful.
Measurements of the Transverse Wakefields Due to Varying Collimator Characteristics
Molloy, S.; Seletskiy, Sergei; Woods, Mike; /SLAC; Smith, Jonathan David Andrew; /Cockcroft Inst. Accel. Sci. Tech.; Beard, Carl David; Fernandez-Hernando, Juan Luis; /Daresbury; Watson, Nigel; /Rutherford; Bungau, Adriana; /Manchester U.; Sopczak, Andre; /Lancaster U.
We report on measurements of the transverse wakefields induced by collimators of differing characteristics. An apparatus allowing the insertion of different collimator jaws into the path of a beam was installed in End Station A (ESA) in SLAC. Eight comparable collimator geometries were designed, including one that would allow easy comparison with previous results, and were installed in this apparatus. Measurements of the beam kick due to the collimator wakefields were made with a beam energy of 28.5 GeV, and beam dimensions of 100 microns vertically and a range of 0.5 to 1.5 mm longitudinally. The trajectory of the beam upstream and downstream of the collimator test apparatus was determined from the outputs of ten BPMs (four upstream and six downstream), thus allowing a measurement of the angular kick imparted to the beam by the collimator under test. The transverse wakefield was inferred from the measured kick. The different aperture designs, data collection and analysis, and initial comparison to theoretical and analytic predictions are presented here.
Bomb-Pulse Chlorine-36 At The Proposed Yucca Mountain Repository Horizon: An Investigation Of Previous Conflicting Results And Collection Of New Data
J. Cizdziel
Previous studies by scientists at Los Alamos National Laboratory (LANL) found elevated ratios of chlorine-36 to total chloride ({sup 36}Cl/Cl) in samples of rock collected from the Exploratory Studies Facility (ESF) and the Enhanced Characterization of the Repository Block (ECRB) at Yucca Mountain as the tunnels were excavated. The data were interpreted as an indication that fluids containing 'bomb-pulse' {sup 36}Cl reached the repository horizon in the {approx}50 years since the peak period of above-ground nuclear testing. Moreover, the data support the concept that so-called fast pathways for infiltration not only exist but are active, possibly through a combination of porous media, faults and/or other geologic features. Due to the significance of {sup 36}Cl data to conceptual models of unsaturated zone flow and transport, the United States Geological Survey (USGS) was requested by the Department of Energy (DOE) to design and implement a study to validate the LANL findings. The USGS chose to drill new boreholes at select locations across zones where bomb-pulse ratios had previously been identified. The drill cores were analyzed at Lawrence Livermore National Laboratory (LLNL) for {sup 36}Cl/Cl using both active and passive leaches, with the USGS/LLNL concluding that the active leach extracted too much rock-Cl and the passive leach did not show bomb-pulse ratios. Because consensus was not reached between the USGS/LLNL and LANL on several fundamental points, including the conceptual strategy for sampling, interpretation and use of tritium ({sup 3}H) data, and the importance and interpretation of blanks, in addition to the presence or absence of bomb-pulse {sup 36}Cl, an evaluation by an independent entity, the University of Nevada, Las Vegas (UNLV), using new samples was initiated. This report is the result of that study. The overall objectives of the UNLV study were to investigate the source or sources of the conflicting results from the previous validation study, and to obtain additional data to determine whether or not there are bomb-pulse isotopes at the repository horizon. To that en4 we have engaged in discussions with previous investigators, reviewed reports, and analyzed archived samples. We have also collected new samples of rock from the ESF, soil profiles from the surface of Yucca Mountain, and opportunistic samples of seep water from inside the south ramp of the ESF.
Severe haemoptysis due to subclavian arteritis.
Lioulias, A; Misthos, P; Kokotsakis, J; Drosos, O; Karagiannidis, N; Pavlopoulos, D; Mitselou, M
Severe haemoptysis due to infective subclavian arteritis has, to our knowledge, never been documented. We report a case of subclavian arterial vasculitis that eroded into the left lung apex, causing a large intraparenchymal mycotic pseudoaneurysm. The patient presented with high fever and blood expectoration. An emergent left lateral thoracotomy was performed. The inflamed segment of the subclavian artery was resected and continuity was restored with a reversed saphenous vein graft. The postoperative course was uneventful and the patient was discharged on the 10th postoperative day. PMID:22732928
NASA Astrophysics Data System (ADS)
Kivshar, Yuri S.
It is shown analytically that gap solitons can occur in materials with ?(2) susceptibility due to cascaded second-order nonlinearities. Families of bright and dard spatial gap solitons are described in the framework of asymptotic expansions that are valid, in particular, for nonzero phase mismatch between the first and second harmonics; effective coefficients of self- and cross-phase modulation are calculated.
Name ____________________ Due Monday Feb 4
Kirby, Carl S.
: earth, box (holding the seismograph), spring or lever holding a mass, mass (attached to a pen), recording paper. When an earthquake occurs, the Earth, the box holding the seismograph, the spring or lever, and the recording paper all move together. Due to its inertia and because it is mounted on a spring or lever
Maternal Psychological Distress and Placental Circulation in Pregnancies after a Previous Offspring with Congenital Malformation
Helbig, Anne; Kaasen, Anne; Malt, Ulrik Fredrik; Haugen, Guttorm
Introduction Antenatal maternal psychological distress may be associated with reduced placental circulation, which could lead to lower birthweight. Studies investigating this in humans show mixed results, which may be partially due to type, strength and timing of distress. In addition, the arterial vascular resistance measures often used as outcome measures do not detect smaller changes in placental volume blood flow. We aimed to investigate the effect of a specific stressor, with increased levels of stress early in pregnancy, on the fetoplacental volume blood flow in third trimester. Methods This was a prospective observational study of 74 pregnant women with a congenital malformation in a previous fetus or child. Psychological distress was assessed twice, around 16 and 30 weeks' gestation. Psychometric measures were the General Health Questionnaire-28 (subscales anxiety and depression), Edinburgh Postnatal Depression Scale, and Impact of Event Scale-22 (subscales intrusion, avoidance, and arousal). Placental circulation was examined at 30 weeks, using Doppler ultrasonography, primarily as fetoplacental volume blood flow in the umbilical vein, normalized for abdominal circumference; secondarily as vascular resistance measures, obtained from the umbilical and the uterine arteries. Results Maternal distress in second but not third trimester was associated with increased normalized fetoplacental blood flow (P-values 0.006 and 0.013 for score > mean for depression and intrusion, respectively). Post-hoc explorations suggested that a reduced birthweight/placental weight ratio may mediate this association. Psychological distress did not affect vascular resistance measures in the umbilical and uterine arteries, regardless of adjustment for confounders. Conclusions In pregnant women with a previous fetus or child with a congenital malformation, higher distress levels in second trimester were associated with third trimester fetoplacental blood flow that was higher than expected for the size of the fetus. The results do not support placental blood flow reduction as a pathway between maternal distress and reduced birthweight. PMID:24475155
613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review
Background Rupture of the spleen in the absence of trauma or previously diagnosed disease is largely ignored in the emergency literature and is often not documented as such in journals from other fields. We have conducted a systematic review of the literature to highlight the surprisingly frequent occurrence of this phenomenon and to document the diversity of diseases that can present in this fashion. Methods Systematic review of English and French language publications catalogued in Pubmed, Embase and CINAHL between 1950 and 2011. Results We found 613 cases of splenic rupture meeting the criteria above, 327 of which occurred as the presenting complaint of an underlying disease and 112 of which occurred following a medical procedure. Rupture appeared to occur spontaneously in histologically normal (but not necessarily normal size) spleens in 35 cases and after minor trauma in 23 cases. Medications were implicated in 47 cases, a splenic or adjacent anatomical abnormality in 31 cases and pregnancy or its complications in 38 cases. The most common associated diseases were infectious (n?=?143), haematologic (n?=?84) and non-haematologic neoplasms (n?=?48). Amyloidosis (n?=?24), internal trauma such as cough or vomiting (n?=?17) and rheumatologic diseases (n?=?10) are less frequently reported. Colonoscopy (n?=?87) was the procedure reported most frequently as a cause of rupture. The anatomic abnormalities associated with rupture include splenic cysts (n?=?6), infarction (n?=?6) and hamartomata (n?=?5). Medications associated with rupture include anticoagulants (n?=?21), thrombolytics (n?=?13) and recombinant G-CSF (n?=?10). Other causes or associations reported very infrequently include other endoscopy, pulmonary, cardiac or abdominal surgery, hysterectomy, peliosis, empyema, remote pancreato-renal transplant, thrombosed splenic vein, hemangiomata, pancreatic pseudocysts, splenic artery aneurysm, cholesterol embolism, splenic granuloma, congenital diaphragmatic hernia, rib exostosis, pancreatitis, Gaucher's disease, Wilson's disease, pheochromocytoma, afibrinogenemia and ruptured ectopic pregnancy. Conclusions Emergency physicians should be attuned to the fact that rupture of the spleen can occur in the absence of major trauma or previously diagnosed splenic disease. The occurrence of such a rupture is likely to be the manifesting complaint of an underlying disease. Furthermore, colonoscopy should be more widely documented as a cause of splenic rupture. PMID:22889306
Defining the phenotype in congenital disorder of glycosylation due to ALG1 mutations.
Morava, Eva; Vodopiutz, Julia; Lefeber, Dirk J; Janecke, Andreas R; Schmidt, Wolfgang M; Lechner, Silvia; Item, Chike B; Sykut-Cegielska, Jolanta; Adamowicz, Maciej; Wierzba, Jolanta; Zhang, Zong H; Mihalek, Ivana; Stockler, Sylvia; Bodamer, Olaf A; Lehle, Ludwig; Wevers, Ron A
Deficiency of ?-1,4 mannosyltransferase (MT-1) congenital disorder of glycosylation (CDG), due to ALG1 gene mutations. Features in 9 patients reported previously consisted of prenatal growth retardation, pregnancy-induced maternal hypertension and fetal hydrops. Four patients died before 5 years of age, and survivors showed a severe psychomotor retardation. We report on 7 patients with psychomotor delay, microcephaly, strabismus and coagulation abnormalities, seizures and abnormal fat distribution. Four children had a stable clinical course, two had visual impairment, and 1 had hearing loss. Thrombotic and vascular events led to deterioration of the clinical outcome in 2 patients. Four novel ALG1 mutations were identified. Pathogenicity was determined in alg1 yeast mutants transformed with hALG1. Functional analyses showed all novel mutations representing hypomorphs associated with residual enzyme activity. We extend the phenotypic spectrum including the first description of deafness in MT1 deficiency, and report on mildly affected patients, surviving to adulthood. The dysmorphic features, including abnormal fat distribution and strabismus highly resemble CDG due to phosphomannomutase-2 deficiency (PMM2-CDG), the most common type of CDG. We suggest testing for ALG1 mutations in unsolved CDG patients with a type 1 transferrin isoelectric focusing pattern, especially with epilepsy, severe visual loss and hemorrhagic/thrombotic events. PMID:22966035
M ▄nsel; R Ersoy; A Kokuludag
? Abstract We report the case of a 28-year-old man who presented palatal itching and genaralized urticaria following ingestion of olive 3 years after being diagnosed with olive pollinosis. The patient did not have a history of food allergy or urticaria. The results of skin prick tests with aeroallergens including latex were positive for house dust mite and olive pollen.
Previous PICC Placement May Be Associated With Catheter-Related Infections in Hemodialysis Patients
Butler, Philip J., E-mail: email@example.com; Sood, Shreya; Mojibian, Hamid; Tal, Michael G. [Yale University School of Medicine, Department of Diagnostic Radiology (United States)
Background: Catheter-related infections (CRIs) are a significant source of morbidity and mortality in hemodialysis patients. The identification of novel, modifiable risk factors for CRIs may lead to improved outcomes in this population. Peripherally inserted central catheters (PICCs) have been hypothesized to compromise vascular access due to vascular damage and venous thrombosis, whereas venous thrombosis has been linked to the development of CRIs. Here we examine the association between PICC placement and CRIs. Methods: A retrospective review was performed of all chronic hemodialysis catheter placements and exchanges performed at a large university hospital from September 2003 to September 2008. History of PICC line use was determined by examining hospital radiologic records from December 1993 to September 2008. Catheter-related complications were assessed and correlated with PICC line history. Results: One hundred eighty-five patients with 713 chronic tunneled hemodialysis catheter placements were identified. Thirty-eight of those patients (20.5%) had a history of PICC placement; these patients were more likely to have CRIs (odds ratio = 2.46, 95% confidence interval = 1.71-3.53, p < .001) compared with patients without a history of PICC placement. There was no difference between the two groups in age or number of catheters placed. Conclusion: Previous PICC placement may be associated with catheter-related infections in hemodialysis patients.
Ofatumumab and bendamustine in previously treated chronic lymphocytic leukemia and small lymphocytic lymphoma.
Ujjani, Chaitra; Ramzi, Pari; Gehan, Edmund; Wang, Hongkun; Wang, Yiru; Cheson, Bruce D
Despite initial responses > 90% with fludarabine and rituximab-based regimens, patients with chronic lymphocytic leukemia (CLL) invariably relapse and require further treatment. Ofatumumab and bendamustine have each shown efficacy in relapsed/refractory CLL with overall response rates (ORRs) of 58% and 76%, respectively. Given excellent data with bendamustine and rituximab in relapsed/refractory CLL/small lymphocytic lymphoma (SLL), this phase II study evaluated the combination of ofatumumab and bendamustine in previously treated patients. Patients received ofatumumab 300 mg intravenously (IV) day - 7, followed by ofatumumab 1000 mg IV day 1 and bendamustine 70 mg/m(2) days 1 and 2 of each 28-day cycle. Patients received 4-6 cycles depending on number of prior therapies, as long as well-tolerated or until progression. Of 10 patients enrolled, the ORR was 40% and complete response rate was 20%. The median progression-free and overall survivals were 8.1 months and 16.2 months. Three patients developed Richter transformation. The study was closed early due to unexpected adverse events including infusion-related reactions, infection and neurotoxicity. PMID:24925211
Vaccinia-based influenza vaccine overcomes previously induced immunodominance hierarchy for heterosubtypic protection.
Kwon, Ji-Sun; Yoon, Jungsoon; Kim, Yeon-Jung; Kang, Kyuho; Woo, Sunje; Jung, Dea-Im; Song, Man Ki; Kim, Eun-Ha; Kwon, Hyeok-Il; Choi, Young Ki; Kim, Jihye; Lee, Jeewon; Yoon, Yeup; Shin, Eui-Cheol; Youn, Jin-Won
Growing concerns about unpredictable influenza pandemics require a broadly protective vaccine against diverse influenza strains. One of the promising approaches was a T cell-based vaccine, but the narrow breadth of T-cell immunity due to the immunodominance hierarchy established by previous influenza infection and efficacy against only mild challenge condition are important hurdles to overcome. To model T-cell immunodominance hierarchy in humans in an experimental setting, influenza-primed C57BL/6 mice were chosen and boosted with a mixture of vaccinia recombinants, individually expressing consensus sequences from avian, swine, and human isolates of influenza internal proteins. As determined by IFN-? ELISPOT and polyfunctional cytokine secretion, the vaccinia recombinants of influenza expanded the breadth of T-cell responses to include subdominant and even minor epitopes. Vaccine groups were successfully protected against 100 LD50 challenges with PR/8/34 and highly pathogenic avian influenza H5N1, which contained the identical dominant NP366 epitope. Interestingly, in challenge with pandemic A/Cal/04/2009 containing mutations in the dominant epitope, only the group vaccinated with rVV-NP + PA showed improved protection. Taken together, a vaccinia-based influenza vaccine expressing conserved internal proteins improved the breadth of influenza-specific T-cell immunity and provided heterosubtypic protection against immunologically close as well as distant influenza strains. PMID:24825439
Defining 'signal' and its subtypes in pharmacovigilance based on a systematic review of previous definitions.
Hauben, Manfred; Aronson, Jeffrey K
Having surveyed the etymology and previous definitions of the pharmacovigilance term 'signal', we propose a definition that embraces all the surveyed ideas, reflects real-world pharmacovigilance processes, and accommodates signals of both harmful and beneficial effects. The essential definitional features of a pharmacovigilance signal are (i) that it is based on one or more reports of an association between an intervention or interventions and an event or set of related events (e.g. a syndrome), including any type of evidence (clinical or experimental); (ii) that it represents an association that is new and important and has not been previously investigated and refuted; (iii) that it incites to action (verification and remedial action); (iv) that it does not encompass intervention-event associations that are not related to causality or risk with a specified degree of likelihood and scientific plausibility. Based on these features, we propose this definition of a signal of suspected causality: "information that arises from one or multiple sources (including observations and experiments), which suggests a new potentially causal association, or a new aspect of a known association, between an intervention and an event or set of related events, either adverse or beneficial, which would command regulatory, societal or clinical attention, and is judged to be of sufficient likelihood to justify verifiable and, when necessary, remedial actions." This defines an unverified signal; we have also defined term-- indeterminate, verified, and refuted signals--that qualify it in relation to verification. This definition and its accompanying flowchart should inform decision making in considering benefits and harms caused by pharmacological and nonpharmacological interventions. PMID:19236117
Phase II study of personalized peptide vaccination for previously treated advanced colorectal cancer.
Kibe, Shiro; Yutani, Shigeru; Motoyama, Satoru; Nomura, Takanobu; Tanaka, Natsuki; Kawahara, Akihiko; Yamaguchi, Tomohiko; Matsueda, Satoko; Komatsu, Nobukazu; Miura, Masatomo; Hinai, Yudai; Hattori, Satoshi; Yamada, Akira; Kage, Masayoshi; Itoh, Kyogo; Akagi, Yoshito; Sasada, Tetsuro
The prognosis of advanced colorectal cancer (aCRC) remains poor, and development of new therapeutic approaches, including immunotherapy, is needed urgently. Herein we report on our phase II study of personalized peptide vaccination (PPV) in 60 previously treated patients with aCRC, who had failed at least one regimen of standard chemotherapy and/or targeted therapy. For PPV, a maximum of four HLA-matched peptides were individually selected from a pool of 31 different peptide candidates based on preexisting host immunity, and administered subcutaneously without severe adverse events. Boosting of IgG and cytotoxic T lymphocyte (CTL) responses specific to the administered peptides was observed in 49% and 63%, respectively, of the patients, who completed the first cycles of six vaccinations. Median overall survival (OS) time was 498 days, with 1- and 2-year survival rates of 53% and 22%, respectively. Multivariate Cox regression analysis of prevaccination factors showed that plasma IL6, IP-10, and BAFF levels were significantly prognostic for OS [hazard ratio (HR), 1.508, P = 0.043; HR, 1.579, P = 0.024; HR, 0.509, P = 0.002, respectively]. In addition, increased peptide-specific CTL responses after vaccination were significantly predictive of favorable OS (HR, 0.231; P = 0.021), suggesting a causal relationship between biologic and clinical efficacy of PPV. On the basis of the safety profile and potential clinical efficacy, we believe that clinical trials of PPV would be warranted for previously treated patients with aCRC. PMID:25351849
Fire Department Attended and Unattended Fires: Estimates from the 2004¢2005 National Sample Survey and Comparison with Previous Surveys
Michael A. Greene; Craig D. Andres
Previous national surveys in 1974 and 1984 have shown that although attended and unattended fires differed substantially in\\u000a severity and fire losses, there were between 10 and 29 unwanted residential fires for every fire reported to, or attended\\u000a by, U.S. fire departments. The study objective was to obtain new estimates of fires not attended by fire departments. Interest\\u000a in unattended
Dermatosparaxis (Ehlers-Danlos type VIIC): prenatal diagnosis following a previous pregnancy with unexpected skull fractures at delivery.
Solomons, Joyce; Coucke, Paul; Symoens, Sofie; Cohen, Marta C; Pope, F Michael; Wagner, Bart E; Sobey, Glenda; Black, Rebecca; Cilliers, Deirdre
Dermatosparaxis Ehlers-Danlos syndrome (or EDS VIIC), a rare autosomal recessive connective tissue disorder, is characterized by extreme skin fragility, premature rupture of membranes in pregnancy, and spontaneous rupture of internal organs. Here we report a second patient with EDS VIIC presenting with congenital skull fractures and skin lacerations at birth, complications which may occur more frequently than previously thought in this condition. We also discuss the role of prenatal diagnosis in the management of a subsequent normal pregnancy. PMID:23495203
Occupational allergy due to seafood delivery: Case report
Cornelia S Seitz; Eva B Br÷cker; Axel Trautmann
BACKGROUND: Sensitization to fish or crustaceans requires intensive skin contact and\\/or airway exposition and therefore especially workers in the seafood processing industry may develop an occupational seafood allergy. However, even in jobs with limited direct exposure, individuals with atopic disposition not using appropriate skin protection are at risk for developing occupational seafood allergy which requires termination of employment. CASE PRESENTATION:
Acute interstitial nephritis due to deferasirox: a case report
Godela Brosnahan; Neriman Gokden; Sundararaman Swaminathan
Deferasirox is a new oral iron chelator used to treat transfu- sional iron overload. Pre-marketing clinical trials revealed little organ-specific toxicity. Increases in serum creati- nine were noted in one-third of patients but were mild and non-progressive. We describe a 62-year-old man with myelodysplasticsyndromewhodevelopedaprogressivede- cline in renal function after starting deferasirox. A kidney biopsy showed acute interstitial nephritis with increased
Retroperitoneal fibrosis due to malignancy: a case report.
Erton, M L; Ilker, Y N; Ceyhan, N; Akda?, A
Retroperitoneal fibrosis is idiopathic in two thirds of cases and is found most commonly as an isolated fibrotic plaque centered over the lumbar spine and entrapping one or both ureters. It has been postulated that fibrosis in the idiopathic cases results from a hypersensitivity reaction to antigens leaking into the retroperitoneum from atheromatous plaques in the aorta or common iliac arteries. In the remaining one third of cases, causes include ergot-derivative drugs, retroperitoneal haemorrhage or urine extravasation, and a desmoplastic response to a variety of tumours. PMID:7591570
Intoxication due to Papaver rhoeas (Corn Poppy): Five Case Reports
Ūekmen, Bora; Ak?ll?, Nazire Belgin; K÷yl³, Ramazan; Cander, Ba?ar
Introduction. In this paper, we aimed to present five Papaver rhoeas intoxication cases, which is very rare in the literature. Case 1. A 35-year-old female patient was admitted to our emergency room with the complaints of nausea, restlessness, and dyspnea developing 3 hours after eating Papaver rhoeas. On physical examination, her general condition was moderate; she was conscious and the vital findings were normal. The pupils were myotic. She was transferred to the toxicology intensive care unit as she experienced a generalized tonic clonic seizure lasting for three minutes. Case 2. A 41-year-old female patient was brought to our emergency room by 112 ambulance as she had contractions in her arms and legs, unconsciousness, and foam coming from her mouth two hours after Papaver rhoeas ingestion. On physical examination, she was confused, the pupils were myotic, and she was tachycardic. Arterial blood gases analysis revealed lactic acidosis. Case 3. A 38-year-old female patient was admitted to our emergency room with complaints of nausea and vomiting two hours after ingestion of Papaver rhoeas. Her physical examination and tests were normal. Case 4. A 34-year-old male patient was admitted to our emergency room with complaints of numbness and loss of power in his arms and legs one hour after Papaver rhoeas ingestion. He was hospitalized at the toxicology intensive care unit for follow-up and treatment. Dyspnea and bradycardia developed on the follow-up. The oxygen saturation without oxygen support was 90%. ECG revealed sinus bradycardia. The cardiac enzymes did not increase. Case 5. A 42-year-old female patient was brought to our emergency room by 112 ambulance with contractions in her arms and legs and unconsciousness two hours after Papaver rhoeas ingestion. On her physical examination, she was confused and the pupils were myotic. Arterial blood gases analysis revealed lactic acidosis. Conclusion. All patients were followed up for a few days and then discharged from the hospital with recovery. Unconscious consumption of Papaver rhoeas leads to a clinical condition resembling morphine intoxication, CNS depression, and epileptic seizures.
Syphilis d'emblķe due to blood transfusion. Case report.
Soendjojo, A; Boedisantoso, M; Ilias, M I; Rahardjo, D
A 58-year-old Chinese woman presented with syphilis d'emblķe. Seven weeks after a blood transfusion lesions appeared on the palms of her hands and the soles of her feet. These gradually increased in number and other lesions developed on the scalp and palatal mucosa. One of the blood donors was found to have had positive serological test results for syphilis but no clinical symptoms or signs. This case illustrates the danger inherent in the use of whole fresh blood for transfusion purposes. PMID:7082977
Haemoptysis due to pulmonary venous stenosis.
Braun, Silke; Platzek, Ivan; Z÷phel, Klaus; Weise, Matthias; Kolditz, Martin; Halank, Michael; Hoeffken, Gert
Haemoptysis is a potentially life-threatening condition with the need for prompt diagnosis. In about 10-20% of all cases the bleeding source remains unexplained with the standard diagnostic approach. The aim of this article is to show the necessity of widening the diagnostic approach to haemoptysis with consideration of pulmonary venous stenosis as a possible cause of even severe haemoptysis and haemoptoe. A review of the literature was performed using the Medline/PubMed database with the terms: "pulmonary venous stenosis", "pulmonary venous infarction" and "haemoptysis". Further references from the case reports were considered. 58 case reports and case collections about patients with haemoptysis due to pulmonary venous stenosis were detected. This review gives an overview about the case reports and discusses the underlying pathophysiology and the pros and cons of different imaging techniques for the detection of pulmonary venous stenosis. Several conditions predispose to the obstruction of the mediastinal pulmonary veins. Clinical findings are unspecific and may be misleading. Pulmonary venous stenosis can be detected using several imaging techniques, yet three-dimensional magnetic resonance-angiography and three-dimensional contrast-enhanced computed tomography are the most appropriate. Pulmonary venous stenosis should be considered in patients with haemoptysis. PMID:24881072
Amnesia due to Fornix Infarction
Shyam S. Moudgil; Mouhannad Azzouz; Abdulkader Al-Azzaz; Marc Haut; Ludwig Gutmann
Background and PurposeŚThe fornix connects various structures involved in memory. We report a patient with anterograde amnesia after an acute ischemic infarct in the anterior fornix. Case DescriptionŚA 71-year-old female with acute-onset amnesia had neuroimaging studies showing ischemic infarction of both columns and the body of the fornix and the genu of the corpus callosum. Neuropsychological evaluation revealed anterograde amnesia
75 FR 39143 - Airworthiness Directives; Arrow Falcon Exporters, Inc. (previously Utah State University); AST...
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9 CFR 95.23 - Previously used meat covers; importations permitted subject to restrictions.
Code of Federal Regulations, 2010 CFR
...2010-01-01 false Previously used meat covers; importations permitted subject...UNITED STATES ¦ 95.23 Previously used meat covers; importations permitted subject...has been used to cover fresh or frozen meats originating in any region...
9 CFR 95.23 - Previously used meat covers; importations permitted subject to restrictions.
Code of Federal Regulations, 2011 CFR
...2011-01-01 false Previously used meat covers; importations permitted subject...UNITED STATES ¦ 95.23 Previously used meat covers; importations permitted subject...has been used to cover fresh or frozen meats originating in any region...
40 CFR Appendix I to Part 1042 - Summary of Previous Emission Standards
Code of Federal Regulations, 2013 CFR
...2013-07-01 false Summary of Previous Emission Standards I Appendix I to Part 1042 Protection of Environment ENVIRONMENTAL...COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042, App. I Appendix I to Part 1042ŚSummary of Previous...
40 CFR Appendix I to Part 1042 - Summary of Previous Emission Standards
Code of Federal Regulations, 2014 CFR
...2014-07-01 false Summary of Previous Emission Standards I Appendix I to Part 1042 Protection of Environment ENVIRONMENTAL...COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042, App. I Appendix I to Part 1042ŚSummary of Previous...
40 CFR Appendix I to Part 1042 - Summary of Previous Emission Standards
Code of Federal Regulations, 2012 CFR
...2012-07-01 false Summary of Previous Emission Standards I Appendix I to Part 1042 Protection of Environment ENVIRONMENTAL...COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042, App. I Appendix I to Part 1042ŚSummary of Previous...
40 CFR Appendix I to Part 1042 - Summary of Previous Emission Standards
Code of Federal Regulations, 2010 CFR
...2010-07-01 false Summary of Previous Emission Standards I Appendix I to Part 1042 Protection of Environment ENVIRONMENTAL...COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042, App. I Appendix I to Part 1042ŚSummary of Previous...
18 CFR 401.114 - Data and information previously disclosed to the public.
Code of Federal Regulations, 2012 CFR
...information previously disclosed to the public. 401.114 Section 401.114...RULES OF PRACTICE AND PROCEDURE Public Access to Records and Information ¦ 401...information previously disclosed to the public. Any Commission record that...
18 CFR 401.114 - Data and information previously disclosed to the public.
Code of Federal Regulations, 2013 CFR
...information previously disclosed to the public. 401.114 Section 401.114...RULES OF PRACTICE AND PROCEDURE Public Access to Records and Information ¦ 401...information previously disclosed to the public. Any Commission record that...
18 CFR 401.114 - Data and information previously disclosed to the public.
Code of Federal Regulations, 2011 CFR
...information previously disclosed to the public. 401.114 Section 401.114...RULES OF PRACTICE AND PROCEDURE Public Access to Records and Information ¦ 401...information previously disclosed to the public. Any Commission record that...
18 CFR 401.114 - Data and information previously disclosed to the public.
Code of Federal Regulations, 2014 CFR
...information previously disclosed to the public. 401.114 Section 401.114...RULES OF PRACTICE AND PROCEDURE Public Access to Records and Information ¦ 401...information previously disclosed to the public. Any Commission record that...
18 CFR 401.114 - Data and information previously disclosed to the public.
Code of Federal Regulations, 2010 CFR
...information previously disclosed to the public. 401.114 Section 401.114...RULES OF PRACTICE AND PROCEDURE Public Access to Records and Information ¦ 401...information previously disclosed to the public. Any Commission record that...
Yeast Surface Display of Two Proteins Previously Shown to Be Protective Against White Spot Syndrome Virus (WSSV) in Shrimp.
Ananphongmanee, Vorawit; Srisala, Jiraporn; Sritunyalucksana, Kallaya; Boonchird, Chuenchit
Cell surface display using the yeasts Saccharomyces cerevisiae and Pichia pastoris has been extensively developed for application in bioindustrial processes. Due to the rigid structure of their cell walls, a number of proteins have been successfully displayed on their cell surfaces. It was previously reported that the viral binding protein Rab7 from the giant tiger shrimp Penaeus monodon (PmRab7) and its binding partner envelope protein VP28 of white spot syndrome virus (WSSV) could independently protect shrimp against WSSV infection. Thus, we aimed to display these two proteins independently on the cell surfaces of 2 yeast clones with the ultimate goal of using a mixture of the two clones as an orally deliverable, antiviral agent to protect shrimp against WSSV infection. PmRab7 and VP28 were modified by N-terminal tagging to the C-terminal half of S. cerevisiae ?-agglutinin. DNA fragments, harboring fused-gene expression cassettes under control of an alcohol oxidase I (AOX1) promoter were constructed and used to transform the yeast cells. Immunofluorescence microscopy with antibodies specific to both proteins demonstrated that mutated PmRab7 (mPmRab7) and partial VP28 (pVP28) were localized on the cell surfaces of the respective clones, and fluorescence intensity for each was significantly higher than that of control cells by flow cytometry. Enzyme-linked immunosorbant assay (ELISA) using cells displaying mPmRab7 or pVP28 revealed that the binding of specific antibodies for each was dose-dependent, and could be saturated. In addition, the binding of mPmRab7-expressing cells with free VP28, and vice versa was dose dependent. Binding between the two surface-expressed proteins was confirmed by an assay showing agglutination between cells expressing complementary mPmRab7 and pVP28. In summary, our genetically engineered P. pastoris can display biologically active mPmRab7 and pVP28 and is now ready for evaluation of efficacy in protecting shrimp against WSSV by oral administration. PMID:26083446
Yeast Surface Display of Two Proteins Previously Shown to Be Protective Against White Spot Syndrome Virus (WSSV) in Shrimp
Ananphongmanee, Vorawit; Srisala, Jiraporn; Sritunyalucksana, Kallaya; Boonchird, Chuenchit
Cell surface display using the yeasts Saccharomyces cerevisiae and Pichia pastoris has been extensively developed for application in bioindustrial processes. Due to the rigid structure of their cell walls, a number of proteins have been successfully displayed on their cell surfaces. It was previously reported that the viral binding protein Rab7 from the giant tiger shrimp Penaeus monodon (PmRab7) and its binding partner envelope protein VP28 of white spot syndrome virus (WSSV) could independently protect shrimp against WSSV infection. Thus, we aimed to display these two proteins independently on the cell surfaces of 2 yeast clones with the ultimate goal of using a mixture of the two clones as an orally deliverable, antiviral agent to protect shrimp against WSSV infection. PmRab7 and VP28 were modified by N-terminal tagging to the C-terminal half of S. cerevisiae ?-agglutinin. DNA fragments, harboring fused-gene expression cassettes under control of an alcohol oxidase I (AOX1) promoter were constructed and used to transform the yeast cells. Immunofluorescence microscopy with antibodies specific to both proteins demonstrated that mutated PmRab7 (mPmRab7) and partial VP28 (pVP28) were localized on the cell surfaces of the respective clones, and fluorescence intensity for each was significantly higher than that of control cells by flow cytometry. Enzyme-linked immunosorbant assay (ELISA) using cells displaying mPmRab7 or pVP28 revealed that the binding of specific antibodies for each was dose-dependent, and could be saturated. In addition, the binding of mPmRab7-expressing cells with free VP28, and vice versa was dose dependent. Binding between the two surface-expressed proteins was confirmed by an assay showing agglutination between cells expressing complementary mPmRab7 and pVP28. In summary, our genetically engineered P. pastoris can display biologically active mPmRab7 and pVP28 and is now ready for evaluation of efficacy in protecting shrimp against WSSV by oral administration. PMID:26083446
The Moderating Effects of Previous Losses and Emotional Clarity on Bereavement Outcome
Sofia I. Castro; Jose Carlos Rocha
The connections between complicated grief and traumatic stress have previously been investigated; however, the learning effects resulting from previous losses and emotional clarity are still unclear. Understanding these effects may shed more light on the general hypotheses of emotional aging. We aimed to assess the moderating effects of emotional clarity and previous losses on bereavement outcome. This study evaluated 190
Mammographic features of ductal carcinoma in situ (DCIS) present on previous mammography
A. J. Evans; A. R. M. Wilson; H. C. Burrell; I. O. Ellis; S. E. Pinder
AIM: To review previous mammograms of women found later to have DCIS and identify features which may have been missed or misinterpreted as benign.METHODS: The previous mammograms of 50 women who developed DCIS were analysed. The mammographic features at diagnosis and on the prior mammograms were compared.RESULTS: 11 (22%) of the previous mammograms were in retrospect abnormal; 5 (45%) of
Asymmetrical reverse vortex flow due to induced-charge electro-osmosis around carbon stacking structures.
Sugioka, Hideyuki
Broken symmetry of vortices due to induced-charge electro-osmosis (ICEO) around stacking structures is important for the generation of a large net flow in a microchannel. Following theoretical predictions in our previous study, we herein report experimental observations of asymmetrical reverse vortex flows around stacking structures of carbon posts with a large height (~110 ?m) in water, prepared by the pyrolysis of a photoresist film in a reducing gas. Further, by the use of a coupled calculation method that considers boundary effects precisely, the experimental results, except for the problem of anomalous flow reversal, are successfully explained. That is, unlike previous predictions, the precise calculations here show that stacking structures accelerate a reverse flow rather than suppressing it for a microfluidic channel because of the deformation of electric fields near the stacking portions; these structures can also generate a large net flow theoretically in the direction opposite that of a previous prediction for a standard vortex flow. Furthermore, by solving the one-dimensional Poisson-Nernst-Plank (PNP) equations in the presence of ac electric fields, we find that the anomalous flow reversal occurs by the phase retardation between the induced diffuse charge and the tangential electric field. In addition, we successfully explain the nonlinearity of the flow velocity on the applied voltage by the PNP analysis. In the future, we expect to improve the pumping performance significantly by using stacking structures of conductive posts along with a low-cost process. PMID:21728661
Immediate Acetylene Reduction by Excised Grass Roots Not Previously Preincubated at Low Oxygen Tensions 1
van Berkum, Peter; Sloger, Charles
Excised roots of Spartina alterniflora Loisel. and corn reduced acetylene in air without the previously reported period of zero activity lasting 8 to 18 hours. The profiles of acetylene-dependent ethylene accumulation by excised roots and intact plants of S. alterniflora were similar. No significant change in the number of bacteria associated with the roots was detectable during the assay. Most of the nitrogenase activity was detected in the roots and rhizomes of the plants. The salt marsh sediment also was capable of reducing acetylene. Additional damage to roots by washing and cutting increased the rate of acetylene reduction with samples incubated in air. Low concentrations of nitrate significantly inhibited the nitrogenase activity associated with the sediment and excised roots, but not with intact plants. Rates of acetylene reduction by excised corn roots were low. Oxidation and endogenous production of ethylene in the absence of acetylene were negligible. Measurements made with excised grass roots as described probably reflect the occurrence and magnitude of nitrogenase activity associated with the plants in the field. PMID:16661045