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Unlock your full potential by getting the one-on-one attention you deserve
Welcome to Master Scholars Test Prep, LLC; a small company that focuses on subject area tutoring and SAT* test preparation. Feel free to browse our site and see what we have to offer.
We are proud to announce our Fall SAT Courses! Our small group courses have helped students throughout Orlando raise their scores by an average of 250 points. Our seasonal courses are a great combination of value and quality. The seasonal course is taught by Jesse Patrick and Chelsea St. Clair. All of our seasonal courses are "hybrid" classes and are taught using a combination of on-line lessons, and in-person instruction The hybrid classes makes use of our SAT Video Series.
With the introduction of a new SAT, we will be offering TWO DIFFERENT SAT courses this Fall. The CURRENT SAT is the one being administered up through January of 2016. This class will be held from 12:45-2:45 on the dates posted in the flier. The NEW SAT will begin with this years PSAT in October, and continue with the March SAT in 2016. Current Juniors have the unique opportunity of taking BOTH tests, which means we are offering a unique deal. If you wish to take both classes this Fall, you only pay $450 (that's half off your second course). The SAT Video Series is included in the cost of the course.
Want to prep on your own? You can have your very own copy of the SAT Student workbook, found here: https://www.createspace.com/4223803 (This is for the current version of the SAT).
Also, don't forget to Like Us on Facebook and follow us on Twitter for important news about upcoming classes.
*SAT is a registered trademark of the College Board, which was not involved in the production of, and does not endorse, this product.


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AlarMe for Windows CE
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AlarMe is an alarm clock and timer program for Windows CE that works great as a bedside alarm or a travelalarm. AlarMe has big digits for easy viewing, configurable snooze intervaland alarm sounds, and 12 or 24 hour formats. The alarm will sound andThe Space Bar acts as a snooze bar and the Enter button cancels the alarm soAlarMe is as easy to use as an alarm clock. AlarMe also has a convenient timer that can be set to count up or down for up to 24 hours.. WebPen - Sign Documents Online. Toucan Multimedia is the home of WebPen, electronic signature widget that enables visitors to sign documents online right on your website using the mouse as a pen.
Free download from Shareware Connection - AlarMe is an alarm clock and timer program for Windows CE that works great as a
Version: 1.0 | Platform:
Released Date: 18-9-2009 | Rating: 0 | Title: AlarMe for Windows CE
Author Url: http://www.toucanmultimedia.com
Program Info Url: http://www.toucanmultimedia.com
Download Url: http://www.toucanmultimedia.com/magicblog/TrialMagicBlog.zip
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Scree Recording Windows Ce
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Public Key File and Email Encryption freeware - DeltaCrypt OneClick Personal: Public Key File, Email Encryption featuring 1024-bit RSA protection, digital signatures, unalterable public keys to keep files of any format and email communications secured. Ideal laptop protection. Personal use only.
VShell Server for Windows - VShell Secure Shell server for Windows and UNIX is a secure alternative to Telnet and FTP that gives you the strong encryption, trusted authentication, and data integrity you need to securely access network resources and transfer data.
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Photo Calculator for Windows - The Photo Calculator for Windows covers 37 digital formats including 9 digital backs and 12 conventional film formats.
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TunnelBear - While internet access has become cheaper and faster over the years, certain downsides of the World Wide Web still looms and affects users. Even if you have the resources and monetary capacity to afford a blazing fast and unlimited internet ...
Diver Reviver - It is not only malware and viruses that can affect performance of your computer. Malfunctioning and outdated drivers for hardware components can also affect speed and performance of a PC perceptibly. While seasoned users take the pain of ...
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Screenpresso Pro - Capturing screenshots and webcam streams can become a necessity at times for PC users. There was a time most users resorted to Windows bundled print screen utility but now there are so many choices to pick from. If you want a feature rich and ...
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Spotflux - Browsing the internet is a common activity among PC users nowadays and it is required for work and personal purposes almost on a daily basis. However, with malware invasion on rise and hackers on prowl, web browsing and download safety has become ...

subset: commoncrawl


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Please Visit our Site Sponsors
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rumble strip sound/needle bearings ect..
ive got that rumble strip sound on my passenger side. its a 2000 f250, 4x4, warn hubs. the back clip in the hubs seems to be popping off everytime i get the noise, ive swapped sides with the hubs and the passenger side back clip is the one that keeps popping off and the noise returns. the wheel bearing assembly is fairly new like 4 months and the needle bearings look like they are ok to me. my question is; does the stub axle shaft supose to have a small intent in it where the needle bearings should ride? i can feel a very slight indent there with my fingers and thought it would be better to ask than take apart the other side to find out.
locking the hubs and driving around some, i dont notice the noise and the clip inside the right side hub didnt pop out so im thinking it is some problem there with the needle bearings. on a side note... if the u joint on that side is going out, could it cause the stub axle to have too much play and cause the hub to bind and pop that clip? the reason i ask that is because the only way i can slide the guts of the warn hub back in is to put a big screwdriver under the ujoint and pry it up so the stub axle moves up and the hub slides on. that seems like too much movement to me. its late and im too lazy to work on it anymore, if anyone has suggestions to speed up the fix id appreciate it
Last edited by shiftychops; 07-11-2013 at 11:06 PM.
It Always seems like Too Much movement to me, but it's really OK to be there in most cases (U-Joints bind, don't cause slop like that)
Next, you're having noise from those needle brgs. That's the test! It makes noise when unlocked because the stub axle is spinning on those bearings. Locked, the stub axle is turning with the hub, the needles aren't doing anything...
So, make sure you have the washers in right. That clip shouldn't be able to pop-off. Maybe you have a problem with the stub axle? How bad was it scored where the needles ride? Have a look here-> Welcome to guzzle's 4x4 Needle Bearing Maintenance Web Page
well i put new bearings in and it cleared up the sound. i am going to take the otherside apart and look at the stub shaft for a comparison but i think it may be ok. the needle bearings looked just fine to me, i was overthinking it, should have just changed them from the start
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Don't be too sure Alan.Although it is a possibility.Wait and see.(I mean about Raham) You say:Maybe it would be a good time for Israel to get closer to China. They`re gonna be the big boys on the block in the next few decades, so why cling to the US as the last bastion for peace?... Firstly they are almost the big boys on the block. Secondly a few years ago it was tried(during the Bush era).We had Chinese in Jerusalem making overtures on several business ventures/proposal/deals. What is more,they were flattering Jewish ingenuity when conducting their parley. But,Bush objected vehemently and Israel had to abort the deal. Which proves that should Israel cut and run leaving the US(the sole friend of Israel,more like anemies nowadays)Israel would be able to do business with many countries who are waiting in the wings. India is another who is waiting with open arms to acquire the know how of the Israelis. So,no big news Alan.
Report: Palestinian, 18, killed in clashes with IDF in West Bank (Haaretz)
from the article: U.S.: Emanuel 'didn't threaten to walk away' from Mideast peace process


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Beachside Towers at Sandestin
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Disappointing Destin
... days! How weird that I have more driving experience in America than the UK. I will definitely be driving on the wrong side when I'm at home, and what the hell is manual these days??? Destin was a good stopover and the beach was lovely, the weather is very temperamental and that ruined it a little. It's also quite commercial and 'chavvy' so I probably wouldn't go back but it was good to see. Next stop New ...
... You won't regret it. Our last full day in Florida was for Leah's birthday, and I guess I can tell you now I'm taking her to Madrid in September as her present! :) we spent the morning very lazily and went shopping later on before an afternoon beach session (in case you hadn't guessed, we lived on that beach, and it was amazing!). Her choice for dinner was Pineapple Willy's, a bit down the coast in Panama City. After a little wait we were sat ...
Days 22 & 23 - Happy Birthday America!
... disappointed they can't join us, and Maxwell and Esme are disappointed Tommy won't be offering wake boarding lessons...I think I am better off for not being tempted to learn how to wakeboard from a 14-year old with no fear and better healing capabilities.
We find a nice sandy beach to sit on, catch up, and grill lunch. Afterward, we take the kids tubing and Pat introduces them to a tubing maneuver he and Tommy call ...
Last day at topsail
We have really enjoyed topsail hill, pretty centrally located, bike riding and mostly private beach access. Plus lakes, kayak and canoe rentals, tall pines to camp under and great staff. Today is red and purple flag day again so no beach. Hit the pool, did some bike riding ...
... them to learn.... Had a scare today with camper... Came back from seaside and only the back a\c was working. The rest of the camper was dead. Thankfully Haole was in the back where it was cool. And Rick was persistent and able to call Rocky Mountain rv and talk through options. Turned out it was the campsite 50amp hookup that was the problem. Very very thankful!! Going inland tomorrow for a kayak trip, looking forward to ...


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|Reviews for Fight or Flight
| sasharose11 chapter 1 . 3/19/2013
Just found this rec'd on Slashsessed blog. Great alternate ending.
| longjourneyJess chapter 1 . 5/11/2012
OOOOh I enjoyed this! I would love more! :)
| HeartOfDarkess chapter 1 . 5/11/2012
ooh i loved this twist on the battle scene. great oneshot hun xx
| sunystone chapter 1 . 5/10/2012
Loved this so much! Wish Ellipse would have ended like this! Now I'm left wanting more of Edward and Riley :D
| OCDJen chapter 1 . 5/9/2012
Yey! I was soo happy to see this in my inbox this morning babe. *happy dance*.
You wrote this out perfectly, loved how Riley was in battle.
Awesome babe x
| mw138 chapter 1 . 5/9/2012
That's how Eclipse SHOULD have ended! LOL! Good job!
| mauralee88 chapter 1 . 5/9/2012
Love Edward/Riley. Great idea, and as always, very well executed. Well done!
| harrytwifan chapter 1 . 5/9/2012
Great job, Sarah. Very interesting take on things. Loved it!


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Network and share knowledge with email marketers from all over the world!
Started by Abhishek Bhandari in Email Industry. Last reply by Steve Henderson Sep 28. 3 Replies 0 Likes
Hi ALL,Does anyone know any good commercials or non commerical MTA to send more millions of email in a day. I know about powerMTA but are there any good alternates available? Thanks,Abhishek Continue
Started by Mike A Sequeira in ISPs & Email Clients. Last reply by Mike A Sequeira Sep 14. 2 Replies 0 Likes
I'm looking at switching from Benchmark to HonestMail.net.Anyone have any experience with this provider? Your feedback is most appareciated.Thx.Mike.Continue
Started by Randy Macdonald in List Management & Acquisition. Last reply by Bill Kaplan Jul 15. 8 Replies 0 Likes
Hello,We are wondering if there are any software apps or services available that can filter a list of domains and sort the domains by country? I am not talking about sorting and filtering emails just by country code (eg. emails ending in .ca are…Continue
Started by Tim in Email Service Providers. Last reply by Gareth Boyd Jun 30. 8 Replies 0 Likes
Hi guys, I have a high volume customer that is looking to change ESP's They are considering guys like Silverpop and ExactTarget, but also Sailthru which I've not heard of.They are looking to improved their integration into Social Networks and…Continue
Started by Meryl R in Design & Coding. Last reply by Tim May 4. 4 Replies 0 Likes
Hi,I'm a graphic designer who from time to time needs to outsource coding of emails and landing pages. I prefer to work with an expert individual web developer over a company. My deadlines are usually tight and most of my clients are Fortune 500…Continue
Started by Tim in Analytics & Metrics. Last reply by Tim Apr 20. 2 Replies 0 Likes
Hi guys, where would I find a list of cloudmark domains?Cheers,TimContinue
Started by Tony in Analytics & Metrics. Last reply by Frank Strzyzewski Feb 23. 2 Replies 0 Likes
We have a very large list (2M) and it costs $5K+ to clean it from hard bounces. I recently purchased List Verify Jeet Pro and it is total junk..doesn't remove the right stuff. Does anyone know any decent list cleaning software? I've found a few…Continue
Started by Tim in Strategy. Last reply by Michael Weisel Jan 26. 7 Replies 0 Likes
Hi guys, Was wondering if anyone out there was using an ad server to server ads into their emails. One of my clients uses Liveintent, which works and produces revenue but the yield is not much (I'm going to be using it for my internal brands…Continue
Started by Rob Stack in Analytics & Metrics. Last reply by Maarten Oelering Jan 26. 3 Replies 0 Likes
Hello,Any recommendations for an Email Deliverability Monitoring product or service? I am using Port25 for delivery, but need to monitor if the emails are reaching the Inbox for the major email clients.I am aware of Returnpath, which may be a great…Continue
Started by Sergio Mandrone in Design & Coding. Last reply by Sergio Mandrone Dec 29, 2014. 2 Replies 1 Like
There are many email editors out there... some are HTML code editors while others are easier to use with drag-n-drop functionality. Curious to see which email editor you guys are using and recommend. Any thoughts?By the way, as a side project at…Continue
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Study found more than 43,000 emergency-room visits during five-year period
TUESDAY, Oct. 20 (HealthDay News) -- Infant car seats have saved countless young lives, but those same seats are also responsible for injuring thousands of youngsters when improperly used outside a vehicle, a new study found.
More than 43,000 infants in the United States required emergency room care between 2003 and 2007 after falling in car seats that were improperly placed on tables, counters and other elevated surfaces. Accidents were even reported after seats rolled over on soft surfaces, such as beds and sofas, the study discovered.
"In our hospital, we saw some fractures caused by these falls, and decided it was probably a wider problem," said study author Dr. Shital Parikh, a pediatric orthopaedist at Cincinnati Children's Hospital Medical Center. "These injuries are not common compared with some other causes, but they are significant enough to take notice."
Parikh was to present the research Monday at the American Academy of Pediatrics' annual meeting in Washington, D.C.
Accidents occur when unrestrained babies, especially those older than 2 months, rock and fidget inside an unattended seat, causing the device to tip over or fall, said Dr. Peter Richel, chief of pediatrics at Northern Westchester Hospital Center, in Mount Kisco, N.Y.
According to Parikh, the most common injuries during the five-year period were to the head, followed by fractures and dislocations. Three babies died.
The study comes two months after another study advised parents to remove their children from infant car seats after a car trip because the seats can compress the chest and lower levels of oxygen.
However, experts all agree that car seats are critical inside a vehicle to protect children from injury in a collision, just like seatbelt restraints protect adults.
In Parikh's study, 62 percent of the accide
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Are you Ki Hun Park?Claim your profile
Publications (174)399.9 Total impact
Article: In vitro characterization of 4'-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s[Show abstract] [Hide abstract]
ABSTRACT: 1. 4'-(p-Toluenesulfonylamide)-4-hydroxychalcone (TSAHC) is a synthetic sulfonylamino chalcone compound possessing anti-cancer properties. The aim of this study was to elucidate the metabolism of TSAHC in human liver microsomes (HLMs) and to characterize the cytochrome P450 (P450) enzymes that are involved in the metabolism of TSAHC. 2. TSAHC was incubated with HLMs or recombinant P450 isoforms (rP450) in the presence of an nicotinamide adenine dinucleotide phosphate, reduced form (NADPH)-regenerating system. The metabolites were identified and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). P450 isoforms, responsible for TSAHC metabolite formation, were characterized by chemical inhibition and correlation studies in HLMs and enzyme kinetic studies with a panel of rP450 isoforms. 3. Two hydroxyl metabolites, that is M1 and M2, were produced from the human liver microsomal incubations (Km and Vmax values were 2.46 µM and 85.1 pmol/min/mg protein for M1 and 9.98 µM and 32.1 pmol/min/mg protein for M2, respectively). The specific P450 isoforms responsible for two hydroxy-TSAHC formations were identified using a combination of chemical inhibition, correlation analysis and metabolism by expressed recombinant P450 isoforms. The known P450 enzyme activities and the rate of TSAHC metabolite formation in the 15 HLMs showed that TSAHC metabolism is correlated with CYP2C and CYP3A activity. The P450 isoform-selective inhibition study in HLMs and the incubation study of cDNA-expressed enzymes also showed that two hydroxyl metabolites M1 and M2 biotransformed from TSAHC are mainly mediated by CYP2C and CYP3A, respectively. These findings suggest that CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5 isoforms are major enzymes contributing to TSAHC metabolism.Xenobiotica 09/2015; DOI:10.3109/00498254.2015.1081306 · 2.20 Impact Factor
Article: Mangosenone F, A Furanoxanthone from Garciana mangostana, Induces Reactive Oxygen Species-Mediated Apoptosis in Lung Cancer Cells and Decreases Xenograft Tumor Growth[Show abstract] [Hide abstract]
ABSTRACT: Mangosenone F (MSF), a natural xanthone, was isolated form Carcinia mangotana, and a few studies have reported its glycosidase inhibitor effect. In this study we investigated the anti lung cancer effect of MSF both in vitro and in vivo. MSF inhibited cancer cell cytotoxicity and induced and induced apoptosis via reactive oxygen species (ROS) generation in NCI-H460. MSF treatment also showed in pronounced release of apoptogenic cytochrome c from the mitochondria to the cytosol, downregulation of Bcl-2 and Bcl-xL, and upregulation of Bax, suggesting that caspase-mediated pathways were involved in MSF-induced apoptosis. ROS activation of the mitogen-activated protein kinase signaling pathway was shown to play a predominant role in the apoptosis mechanism of MSF. Compared with cisplatin treatment, MSF treatment showed significantly increased inhibition of the growth of NCI-H460 cells xenografted in nude mice. Together, these results indicate the potential of MSF as a candidate natural anticancer drug by promoting ROS production. © 2015 The Authors Phytotherapy Research Published by John Wiley & Sons Ltd. © 2015 The Authors Phytotherapy Research Published by John Wiley & Sons Ltd.Phytotherapy Research 08/2015; DOI:10.1002/ptr.5428 · 2.66 Impact Factor
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ABSTRACT: Tyrosinase is the rate-limiting enzyme for the production of melanin and other pigments via the oxidation of l-tyrosine. The methanol extract from Humulus lupulus showed potent inhibition against mushroom tyrosinase. The bioactivity-guided fractionation of this methanol extract resulted in the isolation of seven flavonoids (1-7), identified as xanthohumol (1), 4'-O-methylxanthohumol (2), xanthohumol C (3), flavokawain C (4), xanthoumol B (5), 6-prenylnaringenin (6) and isoxanthohumol (7). All isolated flavonoids (1-7) effectively inhibited the monophenolase (IC50s = 15.4-58.4 µM) and diphenolase (IC50s = 27.1-117.4 µM) activities of tyrosinase. Kinetic studies using Lineweaver-Burk and Dixon-plots revealed that chalcones (1-5) were competitive inhibitors, whereas flavanones (6 and 7) exhibited both mixed and non-competitive inhibitory characteristics. In conclusion, this study is the first to demonstrate that the phenolic phytochemicals of H. lupulus display potent inhibitory activities against tyrosinase.Journal of Enzyme Inhibition and Medicinal Chemistry 07/2015; DOI:10.3109/14756366.2015.1063621 · 2.33 Impact Factor
Article: Anti-Obesity Effects of Soy Leaf via Regulation of Adipogenic Transcription Factors and Fat Oxidation in Diet-Induced Obese Mice and 3T3-L1 Adipocytes[Show abstract] [Hide abstract]
ABSTRACT: The anti-obesity effects of extracts from soy leaves (SLE) cultivated for 8 weeks (8W) or 16 weeks (16W) were investigated in diet-induced obese mice. The effects of kaempferol, an aglycone of the kaempferol glycosides that are the major component of 8W-SLE, and coumestrol, the major component of 16W-SLE, were also investigated in 3T3-L1 adipocytes. Eight-week-old male C57BL/6J mice were randomly divided into normal diet, high-fat diet (HFD), 8W-SLE (HFD+8W-SLE 50 mg kg(-1) day(-1)), 16W-SLE (HFD+16W-SLE 50 mg kg(-1) day(-1)), and Garcinia cambogia extracts (GE) (HFD+GE 50 mg kg(-1) day(-1)) groups. Body weight gain and fat accumulation of white adipose tissue (WAT) were highly suppressed by daily oral administration of 8W-SLE and 16W-SLE for 10 weeks. Supplementing a HFD with 8W-SLE and 16W-SLE regulated the mRNA expression of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (c/EBPα), sterol regulatory element-binding protein-1 (SREBP-1), adipocyte protein 2, and fatty acid synthase (FAS), which are related to adipogenesis, in addition to hormone-sensitive lipase (HSL), carnitine palmitoyl transferase 1 (CPT-1), and uncoupling protein 2 (UCP2), which are related to fat oxidation in WAT. In 3T3-L1 adipocytes, kaempferol and coumestrol exhibited anti-adipogenic effects via downregulation of PPARγ, c/EBPα, SREBP-1, and FAS. Kaempferol and coumestrol increased the expression of HSL, CPT-1, and UCP2.Journal of medicinal food 03/2015; 18(8). DOI:10.1089/jmf.2014.3388 · 1.63 Impact Factor
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ABSTRACT: Abstract Two viral proteases of severe acute respiratory syndrome coronavirus (SARS-CoV), a chymotrypsin-like protease (3CL(pro)) and a papain-like protease (PL(pro)) are attractive targets for the development of anti-SARS drugs. In this study, nine alkylated chalcones (1-9) and four coumarins (10-13) were isolated from Angelica keiskei, and the inhibitory activities of these constituents against SARS-CoV proteases (3CL(pro) and PL(pro)) were determined (cell-free/based). Of the isolated alkylated chalcones, chalcone 6, containing the perhydroxyl group, exhibited the most potent 3CL(pro) and PL(pro) inhibitory activity with IC50 values of 11.4 and 1.2 µM. Our detailed protein-inhibitor mechanistic analysis of these species indicated that the chalcones exhibited competitive inhibition characteristics to the SARS-CoV 3CL(pro), whereas noncompetitive inhibition was observed with the SARS-CoV PL(pro).Journal of Enzyme Inhibition and Medicinal Chemistry 02/2015; DOI:10.3109/14756366.2014.1003215 · 2.33 Impact Factor
Article: Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells[Show abstract] [Hide abstract]
ABSTRACT: Unlabelled: Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Epithelial-mesenchymal transition (EMT) is related to self-renewal capacity and circulating tumor cell (CTC) characteristics for tumor metastasis. Although tumor metastasis is a life-threatening, complicated process that occurs through circulation of tumor cells, mechanistic aspects of self-renewal and circulating capacities have been largely unknown. Hepatic transmembrane 4 L six family member 5 (TM4SF5) promotes EMT for malignant growth and migration, so it was rationalized that TM4SF5, as a hepatocellular carcinoma (HCC) biomarker, might be important for metastatic potential. Here, self-renewal capacity by TM4SF5 was mechanistically explored using hepatocarcinoma cells with or without TM4SF5 expression, and we explored whether they became CTCs using mouse liver-orthotopic model systems. We found that TM4SF5-dependent sphere growth correlated with CD24(-) , aldehyde dehydrogenase (ALDH) activity, as well as a physical association between CD44 and TM4SF5. Interaction between TM4SF5 and CD44 was through their extracellular domains with N-glycosylation modifications. TM4SF5/CD44 interaction activated proto-oncogene tyrosine-protein kinase Src (c-Src)/signal transducer and activator of transcription 3 (STAT3)/Twist-related protein 1 (Twist1)/B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) signaling for spheroid formation, whereas disturbing the interaction, expression, or activity of any component in this signaling pathway inhibited spheroid formation. In serial xenografts using 200∼5,000 cells per injection, TM4SF5-positive tumors exhibited subpopulations with locally increased CD44 expressions, supporting for tumor cell differentiation. TM4SF5-positive, but not TM4SF5- or CD44-knocked-down, cells were identified circulating in blood 4-6 weeks after orthotopic liver injection using in vivo laser scanning endomicroscopy. Anti-TM4SF5 reagent blocked their metastasis to distal intestinal organs. Conclusion: TM4SF5 promotes self-renewal and CTC properties supported by TM4SF5(+) /CD44(+(TM4SF5-bound)) /ALDH(+) /CD24(-) markers during HCC metastasis.Hepatology 01/2015; 61(6):1978–1997. DOI:10.1002/hep.27721 · 11.06 Impact Factor
Article: Protamine sulfate precipitation method depletes abundant plant seed-storage proteins: A case study on legume plants[Show abstract] [Hide abstract]
ABSTRACT: Depletion of abundant proteins is one of the effective ways to improve detection and identification of low-abundance proteins. Our previous study showed that protamine sulfate precipitation (PSP) method can deplete abundant ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) from leaf proteins and is suitable for their in-depth proteome investigation. In this study, we provide evidence that the PSP method can also be effectively used for depletion of abundant seed-storage proteins (SSPs) from the total seed proteins of diverse legume plants including soybean, broad bean, pea, wild soybean, and peanut. The 0.05% PS was sufficient to deplete major SSPs from all legumes tested except for peanut where 0.1% PS was required. SDS-PAGE, Western blotting and 2DE analyses of PS-treated soybean and peanut seed proteins showed enriched spots in PS-supernatant than total proteins. Coefficient of variation percentage (%CV) and principal component analysis of 2DE spots support the reproducibility, suitability, and efficacy of the PSP method for quantitative and comparative seed proteome analysis. MALDI-TOF-TOF successfully identified some protein spots from soybean and peanut. Hence, this simple, reproducible, economical PSP method has a broader application in depleting plant abundant proteins including SSPs in addition to RuBisCO, allowing discussion for comprehensive proteome establishment and parallel comparative studies in plants.This article is protected by copyright. All rights reservedProteomics 01/2015; 15(10). DOI:10.1002/pmic.201400488 · 3.81 Impact Factor
Article: Pterocarpan-Enriched Soy Leaf Extract Ameliorates Insulin Sensitivity and Pancreatic β-Cell Proliferation in Type 2 Diabetic Mice.[Show abstract] [Hide abstract]
ABSTRACT: In Korea, soy (Glycine max (L.) Merr.) leaves are eaten as a seasonal vegetable or pickled in soy sauce. Ethyl acetate extracts of soy leaves (EASL) are enriched in pterocarpans and have potent α-glucosidase inhibitory activity. This study investigated the molecular mechanisms underlying the anti-diabetic effect of EASL in C57BL/6J mice with high-fat diet (HFD)-induced type 2 diabetes. Mice were randomly divided into normal diet (ND), HFD (60 kcal% fat diet), EASL (HFD with 0.56% (wt/wt) EASL), and Pinitol (HFD with 0.15% (wt/wt) pinitol) groups. Weight gain and abdominal fat accumulation were significantly suppressed by EASL. Levels of plasma glucose, HbA1c, and insulin in the EASL group were significantly lower than those of the HFD group, and the pancreatic islet of the EASL group had greater size than those of the HFD group. EASL group up-regulated neurogenin 3 (Ngn3), paired box 4 (Pax4), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), which are markers of pancreatic cell development, as well as insulin receptor substrate 1 (IRS1), IRS2, and glucose transporter 4 (GLUT4), which are related to insulin sensitivity. Furthermore, EASL suppressed genes involved in hepatic gluconeogenesis and steatosis. These results suggest that EASL improves plasma glucose and insulin levels in mice with HDF-induced type 2 diabetes by regulating β-cell proliferation and insulin sensitivity.Molecules 11/2014; 19(11):18493-510. DOI:10.3390/molecules191118493 · 2.42 Impact Factor
Article: Lipoxygenase Inhibitory Effects of Dibenzylbutane Lignans from the Seeds of Myristica fragrans (Nutmeg)Bulletin- Korean Chemical Society 06/2014; 35(10):3095-3098. DOI:10.5012/bkcs.2014.35.10.3095 · 0.80 Impact Factor
Article: Papain-Like Protease (PLpro) Inhibitory Effects of Cinnamic Amides from Tribulus terrestris Fruits.[Show abstract] [Hide abstract]
ABSTRACT: Tribulus terrestris fruits are well known for their usage in pharmaceutical preparations and food supplements. The methanol extract of T. terrestris fruits showed potent inhibition against the papain-like protease (PLpro), an essential proteolylic enzyme for protection to pathogenic virus and bacteria. Subsequent bioactivity-guided fractionation of this extract led to six cinnamic amides (1-6) and ferulic acid (7). Compound 6 emerged as new compound possessing the very rare carbinolamide motif. These compounds (1-7) were evaluated for severe acute respiratory syndrome coronavirus (SARS-CoV) PLpro inhibitory activity to identify their potencies and kinetic behavior. Compounds (1-6) displayed significant inhibitory activity with IC50 values in the range 15.8-70.1 µM. The new cinnamic amide 6 was found to be most potent inhibitor with an IC50 of 15.8 µM. In kinetic studies, all inhibitors exhibited mixed type inhibition. Furthermore, the most active PLpro inhibitors (1-6) were proven to be present in the native fruits in high quantities by HPLC chromatogram and liquid chromatography with diode array detection and electrospray ionization mass spectrometry (LC-DAD-ESI/MS).Biological & Pharmaceutical Bulletin 06/2014; 37(6):1021-8. DOI:10.1248/bpb.b14-00026 · 1.83 Impact Factor
Article: Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC–ESI MS/MS and their xanthine oxidase inhibition[Show abstract] [Hide abstract]
ABSTRACT: Angelica keiskei is used as popular functional food stuff. However, quantitative analysis of this plant's metabolites has not yet been disclosed. The principal phenolic compounds (1–16) within A. keiskei were isolated, enabling us to quantify the metabolites within different parts of the plant. The specific quantification of metabolites (1–16) was accomplished by multiple reaction monitoring (MRM) using a quadruple tandem mass spectrometer. The limit of detection and limit of quantitation were calculated as 0.4–44 μg/kg and 1.5–148 μg/kg, respectively. Abundance and composition of these metabolites varied significantly across different parts of plant. For example, the abundance of chalcones (12–16) decreased as follows: root bark (10.51 mg/g) > stems (8.52 mg/g) > leaves (2.63 mg/g) > root cores (1.44 mg/g). The chalcones were found to be responsible for the xanthine oxidase (XO) inhibition shown by this plant. The most potent inhibitor, xanthoangelol inhibited XO with an IC50 of 8.5 μM. Chalcones (12–16) exhibited mixed-type inhibition characteristics.Food Chemistry 06/2014; 153:20–27. DOI:10.1016/j.foodchem.2013.12.026 · 3.39 Impact Factor
Article: Analysis of etoxazole in red pepper after major modification of QuEChERS for gas chromatography–nitrogen phosphorus detection[Show abstract] [Hide abstract]
ABSTRACT: A major modification to the QuEChERS (quick, easy, cheap, effective, rugged and safe) method was developed for the analysis of etoxazole in red pepper using gas chromatography coupled with a nitrogen–phosphorus detector. Etoxazole was extracted with acetonitrile, partitioned with magnesium sulfate and purified with a solid-phase extraction cartridge. The method showed good linearity with a determination coefficient (R2) of 0.998 for the 0.02–2.0 mg/L concentration range. The method was validated using blank red pepper spiked at 0.2 and 1.0 mg/kg, and the average recovery rate was 74.4–79.1% with relative standard deviations <5% for intra- and inter-day precision. The limits of detection and quantification were 0.007 and 0.02 mg/kg, respectively. The developed method was successfully applied to field-incurred samples, and the presence of etoxazole residues was confirmed using gas chromatography/mass spectrometry. Copyright © 2014 John Wiley & Sons, Ltd.Biomedical Chromatography 06/2014; 28(6). DOI:10.1002/bmc.3130 · 1.72 Impact Factor
Article: Determination of kresoxim-methyl and its thermolabile metabolites in pear utilizing pepper leaf matrix as a protectant using gas chromatography[Show abstract] [Hide abstract]
ABSTRACT: Kresoxim-methyl and its two thermolabile metabolites, BF 490-2 and BF 490-9, were analyzed in pear using a pepper leaf matrix protection to maintain the metabolites inside the gas chromatography system. Samples were extracted with a mixture of ethyl acetate and n-hexane (1:1, v/v) and purified and/or separated using a solid phase extraction procedure. The pepper leaf matrix was added and optimized with cleaned pear extract to enhance metabolite sensitivity. Matrix matched calibration was used for kresoxim-methyl in the pear matrix and for metabolites in the pear mixed with pepper leaf matrix. Good linearity was obtained for all analytes with a coefficient of determination, r2 ⩾ 0.992. Limits of detection (LOD) and quantification (LOQ) were 0.006 and 0.02 mg kg−1 and 0.02 and 0.065 mg kg−1 for kresoxim-methyl and the metabolites, respectively. Recoveries were carried out at two concentration levels and were 85.6–97.9% with a relative standard deviation <2.5%. The method was successfully applied to field incurred pear samples, and only kresoxim-methyl was detected at a concentration of 0.03 mg kg−1.Journal of Advanced Research 05/2014; 5(3):329–335. DOI:10.1016/j.jare.2013.05.003
Article: Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors. Corrigendum[Show abstract] [Hide abstract]
ABSTRACT: Sialidase catalyzes the removal of a terminal sialic acid from glycoconjugates and plays a pivotal role in nutrition, cellular interactions and pathogenesis mediating various infectious diseases including cholera, influenza and sepsis. An array of antiviral sialidase agents have been developed and are commercially available, such as zanamivir and oseltamivir for treating influenza. However, the development of bacterial sialidase inhibitors has been much less successful. Here, natural polyphenolic geranylated flavonoids which show significant inhibitory effects against Cp -NanI, a sialidase from Clostridium perfringens , are reported. This bacterium causes various gastrointestinal diseases. The crystal structure of the Cp -NanI catalytic domain in complex with the best inhibitor, diplacone, is also presented. This structure explains how diplacone generates a stable enzyme–inhibitor complex. These results provide a structural framework for understanding the interaction between sialidase and natural flavonoids, which are promising scaffolds on which to discover new anti-sialidase agents.Acta Crystallographica Section D Biological Crystallography 05/2014; 70(Pt 5):1357-65. DOI:10.1107/S1399004714002971 · 2.67 Impact Factor
Article: Structural basis of a novel activity of bacterial 6-pyruvoyltetrahydropterin synthase homologues distinct from mammalian 6-pyruvoyltetrahydropterin synthase activity[Show abstract] [Hide abstract]
ABSTRACT: Escherichia coli 6-carboxytetrahydropterin synthase (eCTPS), a homologue of 6-pyruvoyltetrahydropterin synthase (PTPS), possesses a much stronger catalytic activity to cleave the side chain of sepiapterin in vitro compared with genuine PTPS activity and catalyzes the conversion of dihydroneopterin triphosphate to 6-carboxy-5,6,7,8-tetrahydropterin in vivo . Crystal structures of wild-type apo eCTPS and of a Cys27Ala mutant eCTPS complexed with sepiapterin have been determined to 2.3 and 2.5 Å resolution, respectively. The structures are highly conserved at the active site and the Zn 2+ binding site. However, comparison of the eCTPS structures with those of mammalian PTPS homologues revealed that two specific residues, Trp51 and Phe55, that are not found in mammalian PTPS keep the substrate bound by stacking it with their side chains. Replacement of these two residues by site-directed mutagenesis to the residues Met and Leu, which are only found in mammalian PTPS, converted eCTPS to the mammalian PTPS activity. These studies confirm that these two aromatic residues in eCTPS play an essential role in stabilizing the substrate and in the specific enzyme activity that differs from the original PTPS activity. These aromatic residues Trp51 and Phe55 are a key signature of bacterial PTPS enzymes that distinguish them from mammalian PTPS homologues.Acta Crystallographica Section D Biological Crystallography 05/2014; 70(Pt 5):1212-23. DOI:10.1107/S1399004714002016 · 2.67 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Anti-rotaviral activities of Sophora flavescens extract (SFE) and stevioside (SV) from Stevia rebaudiana Bertoni either singly or in various combinations were examined in vitro and in vivo using a porcine rotavirus G5[P7] strain. Combination of SFE and SV inhibited in vitro virus replication more efficiently than each single treatment. In the piglet model, SV had no effect on rotavirus enteritis, whereas SFE improved but did not completely cure rotaviral enteritis. Interestingly, combination therapy of SFE and SV alleviated diarrhea, and markedly improved small intestinal lesion score and fecal virus shedding. Acute toxicity tests including the piglet lethal dose 50, and body weight, organ weight and pathological changes for the combination therapy did not show any adverse effect on the piglets. These preliminary data suggest that the combination therapy of SV and SFE is a potential curative medication for rotaviral diarrhea in pigs. Determination of the efficacy of this combination therapy in other species including humans needs to be addressed in the future.Research in Veterinary Science 04/2014; 96(3). DOI:10.1016/j.rvsc.2014.03.011 · 1.41 Impact Factor
Article: Rapid characterisation and comparison of saponin profiles in the seeds of Korean Leguminous species using ultra performance liquid chromatography with photodiode array detector and electrospray ionisation/mass spectrometry (UPLC-PDA-ESI/MS) analysis[Show abstract] [Hide abstract]
ABSTRACT: The present work was reported on investigation of saponin profiles in nine different legume seeds, including soybean, adzuki bean, cowpea, common bean, scarlet runner bean, lentil, chick pea, hyacinth bean, and broad bean using ultra performance liquid chromatography with photodiode array detector and electrospray ionisation/mass spectrometry (UPLC-PDA-ESI/MS) technique. A total of twenty saponins were characterised under rapid and simple conditions within 15min by the 80% methanol extracts of all species. Their chemical structures were elucidated as soyasaponin Ab (1), soyasaponin Ba (2), soyasaponin Bb (3), soyasaponin Bc (4), soyasaponin Bd (5), soyasaponin αg (6), soyasaponin βg (7), soyasaponin βa (8), soyasaponin γg (9), soyasaponin γa (10), azukisaponin VI (11), azukisaponin IV (12), azukisaponin II (13), AzII (14), AzIV (15), lablaboside E (16), lablaboside F (17), lablaboside D (18), chikusetusaponin IVa (19), and lablab saponin I (20). The individual and total saponin compositions exhibited remarkable differences in all legume seeds. In particular, soyasaponin βa (8) was detected the predominant composition in soybean, cowpea, and lentil with various concentrations. Interestingly, soybean, adzuki bean, common bean, and scarlet runner bean had high saponin contents, while chick pea and broad bean showed low contents.Food Chemistry 03/2014; 146:270-7. DOI:10.1016/j.foodchem.2013.09.051 · 3.39 Impact Factor
Article: Potential of 4 '-(p-Toluenesulfonylamide)-4-hydroxychalcone to Inhibit the Human Cytochrome P450 2J2 Isoform[Show abstract] [Hide abstract]
ABSTRACT: Human CYP2J2 isoform, the only member of the human CYP2J subfamily, is also over-expressed in human liver carcinoma tissues and hepatocarcinoma cells, and promotes tumor growth and proliferation. 4′-(p-Toluenesulfonylamide)-4-hydroxychalcone (TSAHC) is a synthetic sulfonylamino chalcone compound, which has anti-cancer effect. Inhibitory potential of a promising anti-cancer agent TSAHC against CYP2J2 activity was evaluated using human liver microsomes. TSAHC inhibited CYP2J2-mediated astemizole O-demethylation activity with K i value of 2.03±0.40 μM in a competitive mode, suggesting that TSAHC is a potential candidate for further evaluation for its CYP2J2 targeting anti-cancer activities. Studies are presently underway to estimate TSAHC as potential therapeutic agent for cancer.Journal of the Korean Society for Applied Biological Chemistry 02/2014; 57(1):31-34. DOI:10.1007/s13765-013-4307-y · 0.69 Impact Factor
Article: Rapid Identification of Cholinesterase Inhibitors from the Seedcases of Mangosteen Using an Enzyme Affinity Assay[Show abstract] [Hide abstract]
ABSTRACT: Enzyme binding affinity has been recently introduced as a selective screening method to identify bioactive substances within complex mixtures. We used an assay which identified small molecule binders of acetylcholinesterase (AChE) using the following series of steps: incubation of enzyme with extract; centrifugation and filtration; identification of small molecule content in the flow through. The crude extract contained 10 peaks in the UPLC chromatogram. However after incubation the enzyme, six peaks were reduced, indicating these compounds bound AChE. All these isolated compounds (2, 3, and 5-8) significantly inhibited human AChE with IC50s = 5.4-15.0 υM and butyrylcholinsterase (IC50s = 0.7-11.0 υM). All compounds exhibited reversible mixed kinetics. Consistent with the binding screen and fluorescence quenching, gamma-mangostin 6 had a much higher affinity for AChE than 9-hydroxycalabaxanthone 9. This validates this screening protocol as a rapid method to identify inhibitors of AChE.Journal of Agricultural and Food Chemistry 01/2014; 62(6). DOI:10.1021/jf405072e · 2.91 Impact Factor
Article: Binding Mode Analyses and Pharmacophore Model Development for Stilbene Derivatives as a Novel and Competitive Class of α-Glucosidase Inhibitors[Show abstract] [Hide abstract]
ABSTRACT: Stilbene urea derivatives as a novel and competitive class of non-glycosidic α-glucosidase inhibitors are effective for the treatment of type II diabetes and obesity. The main purposes of our molecular modeling study are to explore the most suitable binding poses of stilbene derivatives with analyzing the binding affinity differences and finally to develop a pharmacophore model which would represents critical features responsible for α-glucosidase inhibitory activity. Three-dimensional structure of S. cerevisiae α-glucosidase was built by homology modeling method and the structure was used for the molecular docking study to find out the initial binding mode of compound 12, which is the most highly active one. The initial structure was subjected to molecular dynamics (MD) simulations for protein structure adjustment at compound 12-bound state. Based on the adjusted conformation, the more reasonable binding modes of the stilbene urea derivatives were obtained from molecular docking and MD simulations. The binding mode of the derivatives was validated by correlation analysis between experimental Ki value and interaction energy. Our results revealed that the binding modes of the potent inhibitors were engaged with important hydrogen bond, hydrophobic, and π-interactions. With the validated compound 12-bound structure obtained from combining approach of docking and MD simulation, a proper four featured pharmacophore model was generated. It was also validated by comparison of fit values with the Ki values. Thus, these results will be helpful for understanding the relationship between binding mode and bioactivity and for designing better inhibitors from stilbene derivatives.PLoS ONE 01/2014; 9(1):e85827. DOI:10.1371/journal.pone.0085827 · 3.23 Impact Factor
Top Journals
Gyeongsang National University
Shinshū, Gyeongsangnam-do, South Korea
- • Division of Applied Life Science
- • Institute of Agriculture and Life Science
- • Department of Agricultural Chemistry
Chonnam National University
Gwangju, Gwangju, South Korea
- College of Agriculture and Life Sciences
Yeungnam University
Gyeongsan, Gyeongsangbuk-do, South Korea
- Department of Civil Engineering
Kyungpook National University
Daikyū, Daegu, South Korea
- Research Institute of Pharmaceutical Science
Jinju National UniversityGyeongju, Gyeongsangbuk-do, South Korea
Children's Cancer Research InstituteWien, Vienna, Austria
Korea Research Institute of Bioscience and Biotechnology KRIBB
Anzan, Gyeonggi Province, South Korea
- • Infection Control Material Research Center
- • National Research Laboratory of Lipid Metabolism and Atherosclerosis
Seoul National University
Seoul, Seoul, South Korea
- Cancer Research Institute
Chinju National University of EducationShinshū, Gyeongsangnam-do, South Korea


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Microsoft (MSFT -0.8%) gets a boost when Hilliard Lyons analyst Stephen Turner initiates...
Microsoft (MSFT -0.8%) gets a boost when Hilliard Lyons analyst Stephen Turner initiates coverage with a Long Term Buy rating and a PT of $29.50 on the strength of product innovation and revenue backlog. Add Turner to the list of pundits who think MSFT will increase its dividend payout, as he says the company is "shareholder friendly" and will reward investors due to a record level of free cash flow.
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I Hurt Myself Playing Candy Crush
By Christal Roberts on September 23, 2013
BlogHer Original Post
I woke up one day last week and couldn't move my thumb. My left hand throbbed, and the base of my thumb especially felt like it had been crushed in a door. At first I thought I'd slept on it and the pain would subside quickly. But instead of getting better, over hours, then days, the pain got worse.
I must have pulled something in my hand, I thought. After all, I'd spent weeks carting around storage bins as I moved my mother from a house to an apartment. Then in a panic I thought, maybe it's early onset arthritis. But I'm too young for hand arthritis. Knees, yes, but not my hands. And that kind of arthritic pain didn't just pop up overnight, did it?
Despite aspirin, ice and gentle loving care, nothing helped, and I was like a clumsy child when it came to everyday tasks. Picking up a water bottle was excruciating, turning a doorknob or a key was agony, and as for getting dressed, I have two words for you: bra hooks.
It wasn't until three days of pain and a visit to the doctor's office loomed in front of me that I figured out the source of my ailment: Candy Crush Saga.
Yeah, you heard me, I had what I like to call Candy Crush Hand.
Remember "Blackberry Thumb?" Well, CCH is a variation. Also called basal thumb arthritis, it's an inflammation of the basal joint at the base of the thumb. The causes can be a trauma or injury to the thumb, or as in my case the repetitive gripping of my Android in my left hand as I played Candy Crush Saga using the index finger of my right.
For hours. Getting me to level 218.
Tired of Angry Birds, Angry Birds Rio, Angry Birds Star Wars and Angry Birds Seasons, I started playing Candy Crush right after the mobile app was released last November. I got one taste of the challenging puzzle and my addiction began. I played it on my 90-minute commute into the city, during my 30-minute lunch hour, during my 90-minute commute home, and worst of all, sometimes an hour or two or three in bed before going to sleep.
That's right, I gave up my bedside mysteries for the monkey on my back that was Candy Crush Saga. Propped up on pillows, I'd tightly grip my phone in my left hand and use my right to move the candies around. All those pretty, shiny, juicy colored candies. Lining them up in threes, fours and fives. Filling those specialty orders of striped and wrapped candies.
And when I ran out of Candy Crush turns, I played King's latest game, Pet Rescue Saga (Level 170). Back and forth I would go, alternating between candies and pets until the wee hours of the morning.
My thumb did not like it. So, I stopped playing. Briefly. Then when I started up again, instead of gripping the phone in my left hand, I put the phone on my lap, or laid it flat in my palm. The aspirin and the ice then had a chance to work and the pain gradually lessened. Now my case of CCH is almost gone.
But I'm not alone. I bet a survey of the millions of daily Candy Crush users would find a whole range of Candy Crush ailments. Lollipop Goldstein at Stirrup Queens had one of her own. So as a public service announcement, I wanted to get out the word that this is your thumb on Candy Crush Saga. Any questions?
Christal Roberts is a BlogHer contributing editor. You can follow her on Twitter @ChristalRoberts.
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Guangzhou Uwin Houseware Co., Ltd.
mat, PVC mat, PVC, place mat, bath mat, Manufacturer and Supplier - China
Uwin canmping mat is a hard wearing,attractive awning carpet which is breathable product that will allow the grass ti grow.It will perform just as well on wet grass .After placeing iti down it is recommeded to allow a little time for surface evaporat... - Update: 2010-10-07
Size:Regular/Depending on your liking
Colors/designs:Regulation/Depending on your liking
Special: anti slip;soft and safe ;environmantal - Update: 2010-10-07
Warmly invite agents from all over the world to join in "Uwin" sales group to grasp business opportunities and create wealth together. - Update: 2010-10-07
Guangzhou Uwin Housewar Co., Ltd. is a professional manufacturer of new product development and production high-tech PVC anti-slip mats which is located in Guanghzou, China. Products brand "UWIN" including bath mat, place mat, cup mat, carpet mat, no... - Update: 2010-10-07


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5 out of 5 stars Tummy Tuck
Tummy Tuck - I Wish I Had Done This Sooner! - Portland, OR
Show More Dr. L and his staff are exceptional professionals and I highly recommend Dr. L. They are caring, pay attention to detail and have great follow-up. I felt I was well prepared for my procedure and my recovery.
5 out of 5 stars Tummy Tuck
Tummy Tuck with Lipo on Hips
Show More Go to Dr L if you want a perfect body! Hes Wonderful!
5 out of 5 stars Arm Lift
Lipo on my Upper Arms and Incision in Armpit for Armpit Bulge
Show More My Dr has made my journey through this so easy and stress free. I would Highly Recommend Him! Hes very clam and makes you feel at ease at all times. Patti his Nurse was wonderful to work with and made every visit so comfortable for me. Go to see my Dr if you want the body you have always wanted! :)
5 out of 5 stars Non Surgical Nose Job
Non-surgical Nose Job Using Radiesse for Building a Nose Bridge
Show More He really works with you and has a great eye for not just the science (procedures, types of materials, after care) but also the ART ( e.g. What looks the best for your build/structure, How to make you look like a better version of you).
5 out of 5 stars Mommy Makeover
Mommy Makeover Magic!! - Portland, OR
Show More Dr. Lee is quiet, but Who cares he does amazing work. I researched a lot of doctors, and I absolutely without a doubt made the right decision! And Quinby sp? Is awesome
5 out of 5 stars Mommy Makeover
I'm BAAAAA AAAAAACK! - Portland, OR
Show More Dr. Lee is an amazing surgeon. He has a great eye for the human form, very natural contour and sculpture. His after care and follow up? Without a doubt, the best I have ever received from any surgeon or physician. He is brilliantly competent and knowledgable about his proceedures and was very thorough in explaining potential complications or healing delays. I can't reccomend him highly enough. He gave me my life back!
5 out of 5 stars Breast Augmentation
5'3", 125lbs, 32 A to 355cc silicone, 21 Yrs Old, No Kids- Portland, OR
Show More I am orginally from NV, came to Oregon for school, then in August I'll be in North Carolina. After looking up surgeons in all three states I instantly knew Dr. Lee was the one for me. His work is natural, and looking through all his before and afters, not just breast augmentation, all his worked showed great consistency. And after my consultation I had my mind set on Dr. Lee and all his friendly staff.
5 out of 5 stars Tummy Tuck
Mom of Two Waited 10 Years for This! - Portland, OR
Show More I love Dr. Lee! He did an amazing job on my tummy tuck and is very professional! My results and amazing and I could not ask for anything more! Dr. Lee and his staff are top notch!
5 out of 5 stars Breast Lift with Implants
Was in need of perky, fuller boobs after weight loss!
Show More Dr. Lee far exceeded every one of my expectations and wishes! I truly can not say enough about him as a plastic surgeon, and about my results. I had a breast lift and implants placed in December 2014, and am currently about 12 weeks post op. To say I am pleased with my results is really such an understatement. Now when I look at before and after photos on different sites, I almost feel bad that their results are not as amazing as mine, and that they did not have the opportunity to go to Dr. Lee and the team at NW Plastic Surgery. Dr. Lee is more quiet than the other surgeons I saw when I was making all my decisions, but his quiet confidence and the way he presented the information to me made me extremely confident in my decision that he'd be my surgeon the minute I left his office. I was really nervous for the twilight sedation initially, but let me tell you, it was great, and I don't remember a thing. Also, I was not excited for the scars that would be left, but at 12 weeks post op, it is already hard to see the ever fading scars left by the skilled artist Dr. Lee. If you have been considering any plastic surgery procedure, you will be so pleased to pick Dr. Lee as your surgeon of choice. He is truly a master at what he does.
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Savella should be prescribed with caution in patients with a history of a seizure disorder, mania or controlled narrow-angle glaucoma.
Savella has been associated with mild elevations of ALT and AST. Rarely, fulminant hepatitis has been reported in patients treated with milnacipran. Savella should be discontinued in patients who develop jaundice or other evidence of liver dysfunction and should not be resumed unless another cause can be established.
Savella should ordinarily not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease.
As with other SNRIs and SSRIs withdrawal symptoms have been observed following discontinuation of milnacipran. A gradual dose reduction is recommended.
Hyponatremia may occur as a result of treatment with SSRIs and SNRIs, including Savella. Discontinuation should be considered for patients with symptomatic hyponatremia.
SSRIs and SNRIs, including Savella, may increase the risk of bleeding events. Patients should be cautioned regarding the risk of bleeding associated with concomitant use of Savella and NSAIDs, aspirin, warfarin or other drugs that affect coagulation.
Male patients with a history of obstructive uropathies may experience higher rates of genitourinary adverse events.
Savella is unlikely to be involved in clinically significant pharmacokinetic drug interactions. Pharmac
|SOURCE Forest Laboratories, Inc.; Cypress Bioscience, Inc.
Copyright©2009 PR Newswire.
All rights reserved


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Reagan says "Shut Up Hippie!" Classic Ronald Reagan design celebrating the greatest president of the 20th century. A true American Conservative icon
This great custom product in white from our department Men and Tank Top category can be printed just for you in the size and style you like. The design Ronald Reagan Says Shut Up Hippie was created by ForkInTheToaster and uploaded to Spreadshirt for you to have printed on a Tank Top. Next to a host of other great customized designs, you can find this Ronald Reagan Says Shut Up Hippie design in Spreadshirt's Satire category. If you are interested in topics like Funny or Humor, then you'll love Ronald Reagan Says Shut Up Hippie designs by ForkInTheToaster. Spreadshirt also offers a huge selection of custom t-shirts, hoodies and accessories for the category Satire as well as top Irreverent clothing. ForkInTheToaster's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your destination for great designs of all kinds – whether it's Funny, Humor or Irreverent. We are sure that you will find something nice in our shop, there are many amazing custom Satire t-shirts, hoodies, or accessories for you to find! Tags: Design ID: 11921468
Evil Minion Face Designed by Mackentee
Bernie Sanders Silhouette Women's T-Shirts Designed by 5507177
LOVE physical therapy T-Shirts Designed by physiotherapy
Tammy Comedy Movie Mahalo Bear Shirt Designed by Mackentee
Breast Cancer Awareness Shirt Designed by jgivan2000
Hoodini Vanoss Gaming T-Shirts Designed by 3982143
Skeleton X-ray Maternity Shirt Designed by gladditudes
Hit the beach, the street or the gym in this soft, durable tank from the Spreadshirt Collection. Grab a few for the warmer weather and get ready for the gun show. This is a Spreadshirt recommended product.
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Robert Schwentke Steps Into 'The Poison Kitchen'
"R.E.D." director to helm true-life tale of anti-Nazi newspaper the Munchner Post.
COLOGNE, Germany - Robert Schwentke (R.E.D., Flightplan) will direct the Nazi-era drama The Poison Kitchen based the best-selling nonfiction book
Explaining Hitler by Ron Rosenbaum. Matthew Sand (Ninja Assassin) will pen the screenplay for Kitchen, which is based on the chapter of the same name in Rosenbaum's book. In it, he tells the story of the newspaper the Muncher Post, which campaigned against Adolf Hitler and the rise of his Nazi party in the 1920s and 1930s. After the Nazis assumed power in 1933, the Muncher Post was shut down, its printers smashed and its journalists arrested. German-born Schwentke is currently in pre-production on comic book adaptation R.I.P.D., an action comedy about an undead police force starring Ryan Reynolds and Jeff Bridges.
Constantin Film's Robert Kulzer, whose The Three Musketeers reboot bows in Germany later this month, is producing The Poison Kitchen together with Margo Klewans. Constantin film head Martin Moszkowicz is executive producing. The shoot is planned for 2012.
Never miss a story. Stay up-to-date with THR's Daily Headlines.
Must Reads
A Widow's Threats, High-Powered Spats and the Sony Hack: The Strange Saga of 'Steve Jobs'
Rick Moranis Reveals Why He Turned Down 'Ghostbusters' Reboot: "It Makes No Sense to Me"
Hollywood's 100 Favorite TV Shows
Dan Rather Reflects on His Dramatic CBS Exit That Inspired 'Truth': "I Have a Lot of Wounds"
'The Martian's' Matt Damon Talks 'Bourne' Return, Politics and PC Flubs: "Oh My God, I Look Like an Asshole"
The Insane Battle Over Sam Simon's Will — Should the Simpson's Co-Creator's Trust Pay $140,000 Per Year For One Dog's Care?
'Empire's' "Batshit Crazy" Behind-the-Scenes Drama: On the Set of TV's Hottest Show
Hollywood's Notable Deaths of 2015


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Featured Slideshow
Apple CEO Tim Cook warns FBI against weaker encryption laws
Apple chief executive Tim Cook echoed words from the security community on the Federal Bureau of Investigation's current push for backdoor encryption, which could weaken the current mobile encryption techniques used by Apple, Google and other technology companies.
Speaking at the Electronic Privacy Information Center in Washington DC, Cook said "So let me be crystal clear: Weakening encryption or taking it away harms good people who are using it for the right reason," and called the FBI plea for removal of mobile encryption "incredibly dangerous."
Major security flaw spotted on Macs released before 2014
A security bug has been spotted over the weekend that may leave older Apple computers vulnerable. To some, the Mac is impenetrable to viruses and other malicious software, but the rest of us know that's not true as it looks like another security hole has been overlooked by Cupertino.
Mac bug makes rootkit injection as easy as falling asleep
Respected Apple hacker Pedro Vilaça has uncovered a low-level zero day vulnerability in Mac computers that allows privileged users to more easily install EFI rootkits.
Vilaça says the attack, first thought to be an extension of previous research rather than separate zero day, took advantage of unlocked flash protections when machines go into sleep mode.
How to delete your old Apple iCloud backups and free up space
iCloud is Apple's cloud-based, content storage system for its Mac and iOS product lines. Apple provides 5GB of free storage with every iCloud account.
Apple Fixes Security Bugs With First Update for Watch OS
Apple released on Tuesday its first update for Watch OS, the iOS-based operating system that runs on the Apple Watch.
Watch OS 1.0.1 patches a total of 13 vulnerabilities affecting components such as the kernel, Secure Transport, FontParser, the Foundation framework, IOHIDFamily, and IOAcceleratorFamily.
The FontParser issue exists due to the way font files are processed. An attacker can exploit this vulnerability (CVE-2015-1093) to execute arbitrary code by getting a user to process a maliciously crafted font.


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Tradition®/MD Mock-Neck Pointelle Knit Sweater
Clearance-save 65%
Item #:
Online Availability: In-stock
In-store availability - show
About this product
About this product
Product features
Product features
With a relaxed, gentle fit this lovely sweater will look wonderful from day into dinner date. Wear it comfortably at the office with a pair of pants or casually with jeans, the choice is yours. Either way, this knit is sure to appeal to your softer side.
- Soft-touch acrylic
- Relaxed fit: loosely fitted to the body with a generous cut for comfort
- Mock-Neck styling
- Long sleeves
- Faux-pearl details
- Machine wash
You may also like
You may also like
Specifications & warranty
Specifications & warranty
Ratings & reviews
Ratings & reviews
Rated 5 out of 5 by 2Sticks from Perfect The sweater is perfect in every way! The color is rich. The fit is "forgiving". The neckline does the job without "choking".
Date published: 2013-12-18
Rated 5 out of 5 by Marshy from Lightweight but warm A delightful sweater that is thin but still warm enough to wear for a mild winter or a hot winter office as well as Spring or Fall weather. The colors are bright and the small beading makes the sweater dressy enough to wear to the office or out of the office. It is a mock neck so if you don't like turtlenecks this is a good sweater
Date published: 2013-12-11
Rated 5 out of 5 by Grandmatwo from Fast and good quality... I haven't ordered for a couple of years but I saw a sweater that I really liked so ordered that. It came within a few days and was very nice... Good quality. You asked if I would recommend this to others. I already have. Thanks.
Date published: 2013-12-10
Rated 5 out of 5 by MLL75621 from Bonne qualité, bon prix. Ce chandail m'a beaucoup plu et j'en ai commandé deux exemplaires, différentes couleurs. La texture était douce et confortable au toucher. Lorsque j'ai porté mon chandail à une rencontre d'amies, elles m'ont complimenté sur la qualité, le look, en général, et la couleur qui m'allait très bien. J'ai donc décidé d'en acheter deux autres de différentes couleurs et j'ai même pu trouver des pantalons assortis que j'avais déjà achetés chez Sears.
Date published: 2013-11-03
Questions & answers
Questions & answers


text: NPR Staff Ruling Class And Revolution Clash In Sumptuous 'Indian Summers' By NPR Staff • Oct 1, 2015 Set in 1932, Indian Summers is a tale of two communities. The British rule India, and in their annual tradition, they retreat into the hills — with all their Indian servants — to stay cool during the summer. But while the British gossip over gin and tonics, the Indian streets are brewing with calls for independence. The new 10-part British TV drama — about empire and race and relationships that cross those lines — has just had its U.S. debut on Masterpiece on PBS. Michelle Dorrance: 'I Just Knew I Would Never Stop Tap Dancing' By NPR Staff • Sep 29, 2015 People often ask dancer and choreographer Michelle Dorrance when she knew she wanted to become a professional dancer. Her answer is simple: "I just knew I would never stop tap dancing," she tells NPR's Robert Siegel. "I knew it was possible because our masters die with their shoes on. ... You dance until your '90s." With Her Camera, MacArthur 'Genius' Tells An African-American Rust Belt Story By NPR Staff • Sep 29, 2015 On Tuesday, the MacArthur Foundation awarded 33-year-old photographer and video artist LaToya Ruby Frazier a MacArthur Genius Grant. Frazier's work is set in Braddock, Pa., the small town outside Pittsburgh where she grew up. Built on steel, today Braddock is struggling to get by. Frazier tells NPR's Ari Shapiro why she chose to focus her lens on her hometown.Interview Highlights On why she chose Braddock as her subject 'We Need To Be Human': Zuhal Sultan On Starting The Iraqi Youth Orchestra By NPR Staff • Sep 28, 2015 It's difficult enough to start an orchestra, but Zuhal Sultan founded the National Youth Orchestra of Iraq (NYOI) as a teenager in the middle of a war. She brought together 40 young musicians from different Iraqi cities and sectarian backgrounds in an effort to unify a divided nation. Now, six years later, the Euphrates Institute has named her Visionary of the Year. Sandstorms, Explosions, Potatoes, Oh My: 'Martian' Takes Its Science Seriously By NPR Staff • Sep 27, 2015 Some pretty horrible things befall astronaut Mark Watney in the new movie The Martian: sandstorms, explosions, extreme isolation, even frustrations growing potatoes. It's a series of unfortunate events that's at once highly scientific and very entertaining. The Martian is the brainchild of author Andy Weir, who wrote the blockbuster novel that inspired the film. As Weir tells it, he'd always longed for some science fiction with greater emphasis on the science. Pages« first ‹ previous 1 2 3 4 … next › last »


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Originally Posted by StoneNYC
They should put it on the back though, which is essentially what the edge is for film, where you don't print, because you don't expose that area...
I don't think this would work, especially for snobs like me who still stretch their own canvases.
Here's a thought, Stone: If you buy some Ilford printing paper you get stickers with it. You can put those stickers on your negatives.
Last edited by Michael R 1974; 01-08-2014 at 03:57 PM. Click to view previous post history.


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The latest news in digital brand protection, including updates from ICANN's new gTLD program.
CSC's New gTLD Utilization Report – September 2015
by Vincent D'Angelo. The September New gTLD Utilization Report reveals a 22% increase in .brand registrations, and shares some examples of how .brand owners are increasingly beginning to test the waters through the use of microsites and redirects. The doubling


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Hotel Ty Gwenn
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Travel Blogs from La Baule
Evening campers!
... and decided to book for 2 nights initially as its a bit overcast, although the lady on reception promised sun for tomorrow. We pitched the tent quite easily, but Jim keeps wandering around checking it. It's a bit windy so hoping it lasts the night otherwise we're stuffed. :-( just had risotto for dinner and having a cup of tea. We're both pretty tired so think we might play some cards and have an earlyish night. Fingers crossed for sun tomorrow.
Speak to you soon ...
The case of the disappearing donkey
... fix it. He also came to have a look and in no time had taken off the door panel and had a good look at the lock mechanism which turned out to be broken. So there is no instant fix and I may have to spend the next ten days with a permanently locked door. Luckily I am booked into the motorhome garage in Portsmouth at the end of next week so I have emailed to warn them it will need fixing. And I thought the van was doing really well!
Second day of cycling
We were ready to set off by 9am today. Unfortunately, my wish for no pain when I first got on the bike today was unfulfilled. Yes, it was a bit unrealistic, but surely I can hope? Perhaps tomorrow. It's forecast to be 37degrees today and we have a big day of riding planned today. Initially we were doing close to 60kms and that included a short ferry ride. Turns out however, that the ferry doesn't run until tomorrow so we will be riding a bit ...
First day of cycling
We're up for breakfast by 7:30 and we seem to have a table for the tour group set up. Bags are to be at the van by 0845 and we're meant to be on our way by 0900. Well, almost, it is a holiday after all. One of our group broke her wrist some weeks ago and has not been cleared by her doctor to ride so she is doing the tour through a mixture of walking and riding in the van. We get away a bit after 9am. It's foggy this morning and ...
St Nazaire - last stop before Southampton.
... br> It was a major submarine base during WW2 built by the Germans, in the an enormous and imposing concrete bunker.
Opposite the bunker was a fairly new cinema - so that worked out well....
Hoping for good weather tomorrow....
More info and photos to folow.


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R10 New Design Door and FrameWhy buy from RitherdonHow to drill stainless steelBusy June for RitherdonSecurity Gate Feeder Pillars at Bletchley Park25yr GuaranteeWill Straw Factory VisitRitherdon working in conjunction with The University of ManchesterWhere are Ritherdon in 2015Riser FireSeal & FireSeal Report
Sheet Metal Enclosure Specialists
Established in 1895, we have been manufacturing a variety of electrical enclosures and related products for many decades. Our product ranges have evolved considerably over our 120 year history, driven by solving problems for the industries we work with. As a result, our strengths are in the relationships we have with our customers and suppliers; a passion and willingness to invest in innovative design and product development work; all followed, of course, by the manufacture of high quality products in our own factory.