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Calvin Klein Underwear Black multi striped low rise trunks
Item No.0910101562
Item No.0910101562
70% Off - Save a total of £15.40
These low rise trunks from Calvin Klein come in a graphic multi striped design with a black branded waistband. They are made from soft microfibre fabric with added stretch for a body-defining fit.
UK Home Delivery Free (UK orders over £30) or £3.49
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Subject to exceptions, Debenhams is happy to exchange or refund your purchase within 28 days of delivery. Please check here for more details on our returns policy and exceptions.
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Sahara mutual fund launches new scheme
Top Stories
Sahara mutual fund on Tuesday announced the launch of its new scheme Sahara Super 20 fund. The new fund offer is opened for subscription at Rs 10 per unit (plus applicable load). The NFO will close for initial subscription on July 23.
Sahara Super 20 fund is an open-ended growth scheme that aims at providing long-term capital appreciation by investing in pre-dominantly equity and equity related securities of around 20 potentially attractive companies selected out of the top 100 largest market capitalisation companies, at the point of investment. The scheme does not guarantee any assured returns, said a company release.
Naresh Kumar Garg, chief executive officer, Sahara Mutual Fund, said this is the right time to launch a scheme. "The Indian economy is showing signs of revival and is returning to a potential growth path after the global economic slowdown. Political stability is expected to show a better economic growth on the back of improvement in consumer sentiment, policy reforms and projected growth in agriculture and the services sector. It is the large cap companies, mostly the leaders of businesses, which would reflect this growth first and the fund aims at capturing the benefits by investing in such companies.
At least 65 per cent of the total assets will be invested in equity and equity related securities and up to a maximum 35 per cent of the total assets may be invested in debt and money market instruments. The benchmark index of Sahara Super 20 Fund is CNX Nifty. Under the scheme, one can opt for dividend option, (including dividend re-investment option) or growth option. Minimum application amount is Rs 5,000. A Systematic Investment Plan under the scheme is also available, the release said.

subset: commoncrawl


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In 'The Milk and Honey Route,' the series' penultimate episode, Matthew Weiner gave viewers the ultimate parting gift in the form of Betty Francis Draper. Major spoilers ahead if you aren't caught up.Read More »
Everyone grew up in Matthew Weiner's penultimate episode of "Mad Men," but Betty and Sally rightfully stole the show.Read More »
"Mad Men" took another stand for feminism in "Lost Horizon," but this week's was all too tragic.Read More »
Let's take a few moments to talk about Peggy's amazing, inspirational and absolutely spot-on speech.Read More »
When "Mad Men" ends in a month, remember "The Forecast." Because it may have told you what's coming.Read More »
Secretaries and ex-husbands took center stage in a "Mad Men" that addressed how to find yourself, even if you're starting over.Read More »
Mustaches, eye patches and funerals were the big surprises of "Mad Men's" final season premiere, as Don starts his personal quest for satisfaction — by any means necessary.Read More »
Matthew Weiner recently named the 10 films that inspired his AMC series. But here are five more that summon the time and place of 'Mad Men.'Read More »
Matthew Weiner dug deep into the surprising influences of Jewish culture on "Mad Men."Read More »


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Get Certified.
Use Your Expertise to Create New Questions for the CPEN Exam
BCEN® and PNCB invite you to apply for our Item Writing Workshop where you'll use your expertise to write new test questions for the CPEN exam. Exam item writers are vital to creating strong exams that reflect current pediatric emergency nursing practice.
No writing expertise needed. Your expert knowledge and clinical expertise in pediatric emergency nursing care are the only requirements for applying. You have the clinical expertise—BCEN and PNCB will mentor you through the item writing process.
Why volunteer? Item writers receive recognition for their work, consideration for membership in the CPEN Exam Construction Review Committee (ECRC) and no-cost renewal of their CPEN credential during the item writer term. Click on the title for more details and the application process.
All application materials must be received by October 23, 2015
BCEN® would like to thank everyone who applied for the TCRN™ beta exam. All 250 spots have been filled and we are very appreciative of your participation in this process. We wish you well as you sit for the beta exam in October!
For everyone who did not make the cut-off for the beta exam, the demand was tremendous and the application process closed within the first 10 minutes. We understand your disappointment, and we apologize you were not able to register for the beta exam. However, we sincerely thank you for your enthusiasm and encourage you to sit for the final exam when it launches in early 2016.
Please continue to review our website and BCEN's Facebook page for more information on the TCRN program in the months ahead.
BCEN's Certified Emergency Nurse (CEN®), Certified Flight Registered Nurse (CFRN®), and Certified Pediatric Emergency Nurse (CPEN®) credentials have been accredited by the Accreditation Board for Specialty Nursing Certification (ABSNC)


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Stock Report: Xinyuan Real Estate Co. Ltd. Sponsored ADR (XIN) Report Updated: Sep 28, 2015 | Print This Page
Report Features:
Stock Analysis
|Fundamental Grade:
|Sales Growth:
|Operating Margin Growth:
|Earnings Growth:
|Earnings Momentum:
|Earnings Surprises:
|Analyst Earnings Revisions:
|Cash Flow:
|Return on Equity:
|Quantitative Grade:
|Total Grade:
Rating: Monthly View
Rating: Weekly View
|This Week:
|C no change
|Last Week:
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|Two Weeks Ago:
|C no change
Xinyuan Real Estate Co. Ltd. Sponsored ADR© quotemedia
Company Profile
Xinyuan Real Estate Co., Ltd., together with its subsidiaries, engages in the development of residential real estate projects in China. The companys residential projects comprise various multiple residential buildings that include multi-layer apartment buildings, sub-high-rise apartment buildings, or high-rise apartment buildings; and small scale residential properties. Its projects include auxiliary services and amenities, such as retail outlets, leisure and health facilities, kindergartens, and schools. The company also offers property management and other real estate related services, such as gardening and landscaping, and installing intercom systems and fixtures. In addition, it leases properties, including an elementary school, a basement, three clubhouses, five kindergartens, and parking facilities. As of December 31, 2011, the company had completed 22 projects with a total gross floor area (GFA) of approximately 2,143,862 square meters and comprising a total of 24,303 units, as well as 11 projects under construction with a total GFA of 2,647,846 square meters. It primarily operates in seven tier II cities, comprising Hefei, Jinan, Kunshan, Suzhou, Zhengzhou, Xuzhou, and Chengdu. Xinyuan Real Estate Co., Ltd. was founded in 1997 and is headquartered in Beijing, China.
Recent News: Xinyuan Real Estate Co. Ltd. Sponsored ADR
|2015-08-31 00:00:00
|Report of foreign issuer rules 13a-16 and 15d-16 of the Securities Exchange Act - Form 6-K
|2015-08-27 00:22:09
|5.85% To 43% Yields From 9 Sector-Leading Dividend Dogs As Of August 24
|2015-08-26 08:30:00
|Xinyuan Real Estate Co., Ltd. to Attend Upcoming Investor Conferences in New York in September 2015
|2015-08-21 12:02:13
|Xinyuan Real Estate: What Do The Latest Numbers Mean?
|2015-08-12 14:47:29
|Xinyuan Real Estate (XIN) Q2 2015 Results - Earnings Call Transcript
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BEST WESTERN PREMIER Eden Resort & Suites
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
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TravelPod Member ReviewsBEST WESTERN PREMIER Eden Resort & Suites Lancaster
Great value, 2 bedroom, great quality and amenity. Good value restaurants and terrific spa and pool area. Very helpful staff.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Historical Traveler Reviews BEST WESTERN PREMIER Eden Resort & Suites Lancaster
Noisy, noisy, noisy
do not get a suite room, way to close to highway it was so noisy ,the beds were hard, this is afar cry from a resort, it was a truck stop hotel
Great Time!
My family and I went to relax & get away from the busy city of New York. We had an extremely relaxing and fun time! We booked a suite, and expected a room in the hotel but to our surprise we got a two bedroom/ two bathroom villa suite. It had two floors that were very clean and roomy. The bathrooms were spotless, and the sheets were not scratchy. The pools and grounds were also very clean! The staff was very friendly to us.
* For all the people who complained; they must be complainers or maybe just had a bad experience. My family had a great time with no complaints at all. I will definitely recommend this place to others!!*
Great stay!!!
I've been to Lancaster many times & stayed at the Best Western for the first time on my most recent trip. I was there for 3 nights and it was great....best place I've stayed at in the area. The rooms have all been recently redone & are basically brand new. Everything was very clean and I had no problems with maid service. My room was on the first floor and faced the highway but I didn't hear any traffic noise as others have mentioned. The outdoor pool can get crowded (locals can join the pool for the summer) and most chairs are filled up in the afternoon but the pool is large so the crowd isn't really a problem. Friends I was traveling with had rooms facing the indoor pool and complained about the noise. Also, the indoor pool backs up to their banquet room where they have LOTS of events. If the event happens to be having a band, you will hear it if your room faces the indoor pool. While we were there they had 2 weddings, a christening and a couple of corporate conferences so they definitely have a big banquet business. On the nights of the weddings, parking was somewhat tough as the wedding guests use the same parking area as the hotel guests. The parking lot is very large but I still had to circle around a couple of times to find a space. All in all, great place to stay, great location & a really good value for the money.
What a nightmare!!
If you like sleeping on scratchy, dirty and wrinkled sheets, this is the hotel for you!!!! If you like sleeping in a room filled with chlorine smells from the indoor pool, this is it! If you want to stay somewhere that requires you to have a car or pay pricey taxi fares to shopping, or better varieties of dining options, check in at the Eden. Watch out what might be under your bed, I accidently kicked one of my shoes underneath the edge of the bed, when I knelt down to look for my shoe, I was shocked at the amount of garbage under my bed: an empty juice bottle, a baby's pacifier and other pieces of paper trash.
Then there is the "maze-like" setup to get to your room. Hope you don't mind a hike to most rooms. The elevator was out of service during my four night stay.
Several members of the group I was with ate at Garfields and spent several hours recovering in our bathrooms with diarreah. Arthur's breakfast buffet and evening buffet were the best bets for food onsite.
I hope my business travels never take me back to Eden again.
Love the Eden Resort
We stayed at the Eden Resort in Lancaster Pa in June 2005. We absolutely LOVED IT AND WILL BE RETURNING. The indoor and outdoor pools are gorgeous. There is a childrens outdoor pool, hot tub and game room. You can also have lunch delivered to the outdoor pool. We had b'fast and dinner at Garfields which was excellent. Another nice amenity at the resort is that there are bbq grills and picnic tables next to the outdoor pool and a small playground for children. The rooms were spacious and clean as well as the public areas. Service was prompt and courteous. There is a huge supermarket 5 min. away if you decide to grill or pick up snacks. I read in some other reviews that if you have a room off the highway it's very noisy. We did have a room off the highway and you could hear traffic, but it wasn't very loud at all, and it didn't interrupt our sleep. All in all I felt like I was at a Las Vegas luxury hotel without all the traffic, crowds and noise. It's a great place. I highly recommend the Eden Resort. Our next trip to Lancaster will be at the Eden Resort.
Bring earplugs if you choose to stay
I am new to tripadvisor and wish I read the reviews about this hotel before our stay at Eden Resort Inn and Suites. We stayed in a one bedroom studio suite (Room 554) and couldn't wait to leave. I wholeheartedly agree with the review: "If don't like to sleep, a great place to stay" July 15, 2004: from A TripAdvisor Member, Hicksville, NY. This hotel is literally on the interstate and should have highway sound barriers to keep out the noise of semis and other constant traffic. It DID sound like airplanes landing throughout the day and night! We too asked for a quiet room away from the interstate. The desk clerk said, "You can't really hear it." (Hotel personnel should be required to stay a night in the room given to us before saying that.) We decided to stay since we were booked for only two nights, and no other suites were available. To add to the interstate noise, we were on the ground floor and could clearly hear the family in the suite above us constantly talking and walking in to the late night/early morning. The kitchen appliances were very outdated (old full-size refrigerator and stove from the 70s; dial-type microwave). The hotel room itself was clean and spacious. Not at all what I expected and would never stay there again. I will continue to consult tripadvisor to help make all future hotel plans.
Mixed Feelings
Stayed at the Eden for a total of three nights. Nice clean rooms, friendly staff, and convenient to all the attractions in both Lancaster and Hershey. In particular the restaurants on site served great quality food for reasonable prices. We had a room with a balcony overlooking the large pool which is housed in a large solarium type structure which was very well lit and beautiful. The problems became obvious during our family's first swim. The large deck area surrounding the pool was being used for childrens' parties which created a less than tranquil swim. One can understand the kids behavior but was really infuriating was the sight of adults standing around in street clothing openly drinking from cans of beer. On our second night in the pool one of the guests had a pool side party and had a cooler full of beers in plain site of everyone. Again the pool area was crowded with adult men and women fully dressed and drinking from beer cans. I seriously doubted the all these folks were staying as paying guests of the hotel. Don't think I'd be back there soon unless the management gives some serious thought to restricting alcohol use (and ENFORCING its' own rules) and not permitting adults to simply loiter in an area which should be for the enjoyment of swimmers.
Room for all
We had a private suite that slept 8 of us. Plenty of room. It was beautiful. The breakfast buffet was also great. We'd stay again.
Good hotel with parking problems
The Best Western Eden Resort Inn and Suites is a clean and comfortable hotel with an excellent front desk staff. It is convenient to Lancaster city and many places of interest in Lancaster County. However, the restaurant and bar at the hotel are very popular local watering holes, and despite clearly marked parking for the restaurant, non-hotel guests park in the the hotel guest parking area and fill it up. Don't try to leave around 4 p.m. or so to go out for an evening, dinner, etc., and expect to have much parking available before 10 p.m. I would like to have rated this hotel higher, but the parking problem prevents it.
Not Satisfied
Stayed at Best Western Eden Resort for one night. Had a reservation and was given a room on the second floor. No elevator! Had to drag my luggage through construction site, nails, electrical lines, staging, garbage, etc...
I don't know why they gave me a room in this location!!! It was terrible. This was in the back of the hotel. Dark almost scary hallway. Did not like at all. Close to highway and lots of road noise. I would definitely NOT stay at this hotel again.
If you stay there, insist that you get a room in the FRONT of the hotel.
TripAdvisor Reviews BEST WESTERN PREMIER Eden Resort & Suites Lancaster
Travel Blogs from Lancaster
Pumpkins and Corn
What was meant to be a short drive of 4 -5 hours all of a sudden morphed into 7 to 8. An hour wait to cross the border didn't help, along with a detour to visit one of Frank Lloyd - Wright's house which was huge and stunning as well as getting knotted up in one way and dead end streets in Buffalo. 2 hours ticked over and we were on the road to …
Amish Country
... spotting. They were friendly and did not mind being photographed, although a friendly wave, which should be reciprocated, before taking snaps, is recommended. We had lunch in a lively place in the centre of town, where they sold all kinds of sweet fare. I had a sandwich, some soup and a drink, and we then walked around town some more. There are some beautiful houses; some of which are from the ...
Amish Country
... and village shop on site. Quilts are very expensive but well worth the cost since mostly hand sewn. They do use sewing machines these days, just convert them to run off air compressor or keep in work place where they can have electricity. Next for lunch we went to the Kettle Kitchen Village in Intercourse. This was a very commercial place that was businesses owned ...
... Finally crossed into Pennsylvania. We stopped for lunch in Williamsport. It took another 3 hours to get to Gettysburg. First stop at Gettysburg National Lark to look through the info centre. Then we stopped where the Virginian Army was based, at Little Round top and further down road. Lots of monuments, canons, original fencing. Otherwise land is either being farmed or left empty. On to York to our hotel. Didn't arrive till 7pm. A very long ...
Day 1 and day 2 - Flight from JFK to Mumbai
12/12/14 - We are going to India today! Yay! I had to leave school early, so my dad picked me up at around noon. Then my family and I left for the airport. We were flying from JFK to Abu Dhabi first, then from Abu Dhabi to Mumbai. We reached JFK early and had tons of time to kill. So, we decided to have some fun. We took a ride in one of the automatic trains that ...


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Headaches are rarely undiagnosable, says Dr James Le Fanu
There were, at the last count, around 140 types of headache, which can pose something of a diagnostic conundrum for the hard-pressed family doctor in a busy surgery.
It is usually possible, with a few pertinent questions, to distinguish between the common causes: sinusitis (pain over the cheekbones made worse by palpations); tension (pain on the top of the head, radiating back to the neck); or migraine (pain limited to one side, with associated symptoms of nausea, flashing lights and so on).
If the headache falls outside one of these categories, the challenge is to resist the temptation to label it as "probably psychological", and consider, instead, more abstruse possibilities.
This is not an academic exercise, for the more obscure causes do not, in general, tend to respond to pain killers such as codeine, but rather to one specific remedy.
The severity of the headache is a useful clue, because if it is really, really excruciating, like a "red hot poker" or "eagle's claw", and focused around one eye, this is almost certainly the euphemistically-named cluster headache, because they tend to come in clusters. The specific remedies here are quite unusual, involving either inhaling pure oxygen from a cylinder or dripping local anaesthetic drops into the nose on the affected side.
Alternatively, when the headache is confined to one side, excruciating and "never goes away", it goes under the Latin eponym of hemicrania continua, and will respond only to the anti-inflammatory drug indomethacin.
When the headache feels like a steel band is slowly being tightened round the head until it is "unbearable and inescapable", the probable cause is raised pressure within the brain or benign cerebellar hypertension. The response to steroids is described as "miraculous".
The imperative in making an accurate diagnosis of headache as a prerequisite for effective treatment is emphasised by consultant neurologist Peter Goadsby.
"I often see patients whose headaches are labelled with various terms, usually as functional (psychological)," he writes. "But it is rare, in my experience, to encounter an undiagnosable headache."
- Mrs PH from Dorset is not alone in her sensitivity to cold, which is so severe that in bed she needs three hot water bottles plus several layers of clothing and a couple of duvets and blankets on top
A lady from Sussex reports that she "cannot exist" unless the temperature in her room is 90 degrees. Consequently, friends and neighbours are reluctant to visit her and she has become very isolated.
The most likely explanation must be a disturbance of the autonomic nervous system, which balances the amount of internal heat generated by the heart and muscle against its loss through the skin to maintain a constant core temperature.
There is no recognised treatment, but one reader recommends Acrilan imitation sheepskin and blankets as good for conserving heat at night.
The only other suggestion comes from a reader whose disturbed temperature control has the opposite effect of excess sensitivity to heat, resulting in severe night sweats. These symptoms have responded, if not completely, to the drug gabapentin, which has a reputation for being effective in a variety of otherwise "untreatable" disorders of nerve function.
- This week's brace of mysteries begin with Mrs FS, writing on behalf of her 75-year-old sister, who suffers the embarrassing sensation of water trickling down the inside of her leg. But "when she checks, she is completely dry".
Mrs FM from West Sussex reports that since an operation last year for the removal of a polyp from her nose, she snorts continuously. "I cannot stop snorting, especially when I drink, eat or do anything like move across the room." Sleep brings some relief but her doctors have given up on her.
Suggestions are, as always, gratefully received.


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Fiscal Cliff Deal Will Give Floridians a Break, According to Report
Remember when the House voted for a fiscal cliff bill way back when three days ago?
Sure, this might mean some money being taken from your paychecks. But according to a Sun Sentinel report, Florida is one of the big winners in the whole fiscal cliff bill thing.
According to the report, Florida taxpayers will be getting tax breaks if they happen to be a teacher, a college student, parents who adopted, homeowners who need to buy private mortgage insurance, and those building energy-efficient homes. Floridians will also be able to deduct state and local taxes from their federal income taxes in 2012 and 2013 if they itemize deductions.
The middle-class living in the Sunshine State will be able to deduct with no worries on the alternative minimum tax biting them in the ass, if they've deducted mortgage interest and other tax-deductible expenses.
Also, since we don't have a state income tax, Floridians will be able to deduct sales tax from their federal income taxes.
Congress also apparently raised the AMT exemption from $45,000 to $78,750 for married couples and from $32,000 to $50,600 for singles. We'll also apparently be able to deduct sales tax from a large-ticket item purchase -- like, for example, a car.
Students: Up to $2,500 a year with the American Opportunity tax credit. It covers the first $2,000 of a student's qualified education expenses and 25 percent of the next $2,000.
Teachers: WIll get a $250 deduction for buying classroom materials, even if they don't itemize on their federal taxes.
Homeowners: Will be able to deduct qualified premiums of private mortgage insurance or PMI from their federal taxes.
Parents: Can receive up to a $10,000 credit for adopting.
Builders of energy-efficient homes: Can qualify for a credit of up to $2,000 for each home built.
We have no idea what the hell any of this means either, other than it sounds pretty nifty. Also, we're calling the people who handle our taxes so they can translate all this accountantspeak for us.
Follow Chris Joseph on Twitter.
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I got really busy dancing at the end of the night, and didn't bring my camera out again. If you see yourself in the video, feel free to tag yourself!
Music: Give it to Me by Eva Peel, and To Begin Again by Fresh Poulp. I used audiofarm.org as Karen suggested here: vimeo.com/forums/topic:15629
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text: MGP Ingredients Company Profile (NASDAQ:MGPI) Analyst RatingsEarningsDividendsInsider TradesCompany ProfileSocial ActivityToday's Chart Consensus Ratings for MGP Ingredients (NASDAQ:MGPI) (?) The ratings breakdown includes the most recent rating from each analyst that has rated the stock within the last twelve months. The ratings score is a calculation of the average number of sell, hold, buy and strong buy ratings (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). The consensus price target is a mean average of the most recent price target set by each analyst that has set a price target for the stock in the last twelve months.Ratings Breakdown: No ratings tracked in the last 12 months.Consensus Rating:N/A (Score: NaN)Consensus Price Target: N/A Analysts' Ratings History for MGP Ingredients (NASDAQ:MGPI) Show: All Ratings For This Stock Only the Most Recent Rating From Each Brokerage No equities research coverage for this company has been tracked by MarketBeat.com Earnings History for MGP Ingredients (NASDAQ:MGPI)DateQuarterConsensus EstimateActual EPSRevenue EstimateActual RevenueRelease LinkConference CallActions8/6/2015Q215$0.44$85.90 million$92.07 millionViewN/A 5/7/2015Q115$0.28ViewN/A 3/12/2014Q413($0.02)$86.35 million$80.94 millionViewN/A 11/11/2013Q3($0.37)ViewN/A 8/5/2013Q213$0.02$87.26 million$83.71 millionViewN/A 5/6/2013Q1 2014$0.08$86.34 million$86.40 millionViewN/A (Data available from 1/1/2011 forward) Dividend History for MGP Ingredients (NASDAQ:MGPI)AnnouncedPeriodAmountYieldEx-Dividend DateRecord DatePayable DateShare3/13/2015annual$0.060.39%3/24/20153/26/20154/21/2015 3/5/2014quarterly$0.050.84%3/13/20143/17/20144/9/2014 (Data available from 1/1/2013 forward) Insider Trading History for MGP Ingredients (NASDAQ:MGPI)Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionActions8/25/2015M Jeannine StrandjordDirectorBuy5,000$14.93$74,650.00 6/25/2015George W Page JrDirectorBuy2,000$16.50$33,000.00 6/5/2015Augustus C GriffinCEOBuy5,000$17.17$85,850.00 12/16/2014Augustus C GriffinCEOBuy9,000$15.95$143,550.00 11/18/2014M Jeannine StrandjordDirectorBuy5,000$12.37$61,850.00 11/17/2014Augustus C GriffinCEOBuy2,000$12.33$24,660.00 11/17/2014John P BridendallDirectorBuy20,000$12.48$249,600.00 9/15/2014George W Page JrDirectorBuy4,000$10.59$42,360.00 9/12/2014Augustus C GriffinCEOBuy2,400$12.26$29,424.00 8/19/2014George W Page JrDirectorBuy1,500$11.34$17,010.00 8/14/2014George W Page JrDirectorBuy1,000$9.35$9,350.00 8/13/2014Anthony P FoglioDirectorBuy5,000$9.71$48,550.00 8/12/2014George W Page JrDirectorBuy2,500$9.11$22,775.00 5/27/2014Terrence P DunnDirectorBuy25,000$6.70$167,500.00 5/13/2014John P BridendallDirectorBuy22,100$5.75$127,075.00 3/17/2014M Jeannine StrandjordDirectorBuy5,000$6.14$30,700.00 12/6/2013Michael BraudeDirectorSell60,121$5.29$318,040.09 12/12/2012Karen SeabergDirectorSell3,910$3.41$13,333.10 (Data available from 1/1/2013 forward) About MGP Ingredients MGP Ingredients, Inc. is a holding company with no operations of its own. The Company's principal directly-owned operating subsidiaries are MGPI Processing, Inc. and MGPI of Indiana, LLC. The Company through its subsidiaries produces distillery and ingredient products which are derived from corn, rye and barley, and wheat flour, primarily to serve the packaged goods industry. As of December 31, 2013, the Company had three reportable segments: distillery products, which produces food grade alcohol and distillery co-products, such as fuel grade alcohol and distillers feed; ingredient solutions, which produces specialty wheat starches, specialty wheat proteins, commodity wheat starch and vital wheat gluten, and others, which processes wheat proteins and wheat starches to produce eco-friendly products. Headlines: (9/23) Low P/E Stock Of The Day No. 39: MGP Ingredients Inc. (9/29) MGP Ingredients Inc. (MGPI) (9/22) MGP Ingredients Inc. (MGPI) (3/11) MGP Ingredients About To Put More Money In Your Pocket (MGPI) (6/29) MGP Ingredients, Inc. Added to Russell 2000 Index (9/8) MGP Ingredients Completes Share Repurchase (7/27) MGP Ingredients, Inc. Comments on Court Ruling (8/26) Insider Buying: MGP Ingredients Director Purchases 5,000 Shares of Stock (MGPI) (6/28) MGP Ingredients, Inc. Added to Russell 2000 Index (8/26) MGP Ingredients Director M Jeannine Strandjord Purchases 5,000 Shares (MGPI) Industry, Sector and Symbol: Sector: Consumer Goods Industry: Processed & Packaged Goods Sub-Industry: N/A Exchange: NASDAQ Symbol: MGPI CUSIP: Key Metrics: Previous Close: $16.0850 Day Moving Average: $15.52200 Day Moving Average: $15.72P/E Ratio: 10.81P/E Growth: 0.00Market Cap: $284.18MCurrent Quarter EPS Consensus Estimate: $0.54 EPS Additional Links: View MGPI on Google FinanceView MGPI on Yahoo FinanceView MGPI's Company Profile on ReutersSearch for MGP Ingredients Inc on Google MGP Ingredients (NASDAQ:MGPI) Chart for Saturday, October, 3, 2015


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After a parasite that causes zombification begins spreading in Oregon, four middle schoolers try to survive in a Springfield mall. Read more
Funding Unsuccessful
This project's funding goal was not reached on February 2, 2013.
After a parasite that causes zombification begins spreading in Oregon, four middle schoolers try to survive in a Springfield mall.
Naveed Malekafzali (deleted)
Project by
Naveed Malekafzali (deleted)
First created | 0 backed
About this project
LANE is the debut film being produced by the amateur filmmaking production team known as Covert Creations.
Short Synopsis - In the near future, four close friends who attend the local middle school in Eugene, OR are the victims of a massive viral catastrophe. Ophiocordyceps unilateralis, commonly known as the parasite that causes zombification in ants, mutates to be applicable to humans. The initial parasite begins infecting people in eastern Lane County, Oregon. While the group is in school, a large-scale civil disturbance (later learned to be a zombie wave) forces them to try to get out of the town. However, the car they steal only has enough gas to take them to the Gateway Mall in nearby Springfield.Gateway Mall in Eugene, Oregon. As they are trapped in the mall, the group struggles to survive, as they face emotional tension, power outages, food shortages, bandits, and most of all, waves of the undead.
All proceeds will go to paying our actors, purchasing equipment, transportation for out-of-town shoots, and of course, paying for your rewards.
Thank you for taking the time to look at our project, and we hope you donate.
Sincerely, Covert Creations
Risks and challenges
Our biggest challenge is to create a story for a film people will enjoy watching. Drama that is not boring and is enticing is incredibly difficult for amateur directors, and will certainly be our central task at hand.
Also, finding the correct people to act and work on the film will be hard work, as not many people cannot convey the tone the main Covert Creations team wants. We will work diligently to find the right people for the job.
Delays in international delivery may happen, depending on how far away you live (Marshall Islanders, for example, will wait quite a bit of time). However, Covert Creations will work as hard as they can to make sure your rewards get to you as fast as possible.Learn about accountability on Kickstarter
Have a question? If the info above doesn't help, you can ask the project creator directly.
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Full HD Digital Download of the film, along with the previous perk.LessEstimated delivery:Manage your pledge
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Signed Movie Poster for LANE, along with previous perks.Less
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Associate Producer Credit on IMDB, Signed DVD of the film with exclusive Behind the Scenes content, along with the previous perks.Less
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Funding period
- (60 days)


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Looks like a beautiful week for comfort on the river. If the clouds stay overhead, the dry fly fishing will be lights out. Bring layers -it's...
Expect partly sunny to mostly sunny days with temps in the high 60's through the week. Perfect fall days here on the Clark Fork!
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The Elk River is low but is in awesome shape.Terrestrial fishing has been epic on warm days,on cloudy days May Fly hatches have been happening....
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Yesterday's tempest in a Z-cup focused on Pope Francis's curious phrase "self-absorbed promethean neopelagianism," used to describe certain factions within Catholic traditionalism. I remain puzzled that Francis has, on multiple occasions, felt the need to single out traditionalists for criticism, given the nature of evil at large in world. Most traditionalists are good and holy [Read More...]
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 15, 2005
|Filing date
|May 1, 2001
|Priority date
|May 4, 2000
|Fee status
|Also published as
|Publication number
|Peter Boekstegers
|Original Assignee
|Percardia, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (101), Non-Patent Citations (11), Referenced by (34), Classifications (17), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims the benefits of U.S. Provisional Patent Application Ser. No. 60/201,732, filed May 4, 2000.
1. Field of the Invention
The present invention relates to methods and related devices for forming a passageway in a heart wall and delivering a stent therein to supply oxygenated blood flow to vascular structure from a chamber of the heart. For example, the methods and related devices preferably place a stent in the left ventricular heart wall in order to establish a supply of blood from the left ventricle to the coronary artery at a point distal a partial or total occlusion of the artery.
2. Background of the Related Art
A prevalent form of heart failure involves the build-up of plaque on walls of various vascular structure, such as, for example, the coronary artery. The plaque that builds up on the walls can form either a partial or total occlusion in the artery. Such an occlusion may either limit or completely block blood flow through the artery, which typically enters through the aortic valve from the left ventricle. Because the coronary artery supplies blood to the various blood vessels within the muscle forming the heart wall, limiting or blocking of the blood flow through the coronary artery can result in damage to the heart muscle, such as, for example, necrosis. Necrotic tissue can lead to reduced cardiac function by diminishing the pumping capacity of the heart. In some instances, the diminished capacity of the heart can lead to heart attack.
Various techniques have been developed to treat this type of heart condition. For example, a surgical technique, referred to as coronary artery bypass grafting (CABG), involves removing a vein or portion thereof from the patient, usually from the femoral vein, and grafting the vein so as to connect portions of the coronary artery upstream and downstream of the occlusion. Thus, the blood flow is directed around the occlusion and through the vein graft so that the oxygenated blood can be delivered to the vessels in the heart wall. CABG generally is performed as an open surgery resulting in relatively long recovery times. Patients also often experience a large amount of discomfort resulting from harvesting of the veins to be used in CABG. Furthermore, the veins that are grafted to the coronary artery have a limited useful life.
Coronary angioplasty represents another form of treatment of arteries having occlusions that can be performed as an alternative to bypass surgery. In this technique, a balloon catheter is inserted percutaneously into the coronary artery. Once the catheter has been inserted such that the balloon is adjacent the occlusion being treated, the balloon is inflated to dilate the artery in the location of the occlusion. Often this technique involves inflating and deflating the balloon repeatedly to establish the desired dilation of the artery. This technique may include placing a stent in a collinear manner in the artery at the location of the occlusion to maintain the proper dilation of the artery. Delivery of the stent can be accomplished by removing the dilation balloon catheter and then inserting a balloon carrying the stent. A multiple balloon stent delivery catheter may dilate the artery and place the stent in a single insertion of the catheter into the patient.
Another technique that has been used to bypass a partial or total occlusion of the artery includes implanting a stent, or otherwise creating a flow passage, in the myocardial wall between the left ventricle and coronary artery at a position downstream of the occlusion. In this technique, a portion of the blood pumped from the left ventricle flows directly into the coronary artery.
The advantages and purpose of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The advantages and purpose of the invention will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims.
The present invention pertains to methods, and related tools for performing the method, of delivering a stent or other like-device to the heart to connect the left ventricle to the coronary artery to thereby supply blood directly from the ventricle to the coronary artery. In a preferred embodiment, a method may be used to bypass a total or partial occlusion of a coronary artery. The inventive method is relatively quicker and less invasive than other techniques as a result, for example, of the manner in which the device is implanted into the heart and the elimination of the need to harvest veins from the patient to perform a CABG. Moreover, the delivery technique according to an embodiment of the present invention facilitates connecting the ventricle and coronary artery via a stent, the technique ultimately reducing the risk of damage to the coronary artery, as will be explained.
An aspect of the invention includes a method to provide direct blood flow between a heart chamber and a coronary vessel. The method includes placing a guide device through an anterior wall and a posterior wall of the coronary vessel and through a heart wall between the heart chamber and the coronary vessel, forming a passageway in the heart wall at a location defined by the guide device, and placing a stent within the passageway. The method may include insertion of a hollow needle through the anterior wall and the posterior wall of the coronary vessel and through the heart wall, prior to placing the guide device. The guide device may be, for example, a guidewire or other suitable like guide mechanism. According to an aspect of the invention, placing the guide device includes inserting the guidewire through the hollow needle until an end of the guidewire rests in the heart chamber. The hollow needle may be removed after inserting the guidewire through the hollow needle.
According to another aspect of the invention, the method may also include measuring a depth of insertion of the hollow needle. The measuring may be accomplished by viewing markings on the hollow needle that indicate the depth of insertion of the hollow needle or determining a pressure differential between the heart chamber and exterior the heart chamber.
The method according to another aspect of the present invention also includes avoiding intracardiac structures during insertion of the hollow needle, and placing the guide device at a predetermined angle relative to the posterior wall of the coronary vessel, which may include inserting a hollow needle at the predetermined angle through the anterior wall and the posterior wall of the coronary vessel and the heart wall, prior to placing the guide device.
In an aspect of a method of the present invention, the passageway is formed with a dilation device, such as a sheath or an inflation device, which may be in the form of a balloon for example. Forming the passageway may include inserting a balloon into the location defined by the guide device and inflating the balloon. A catheter may carry the balloon over the guide device. The balloon is preferably deflated after forming the passageway and removed from the passageway after deflation.
In another aspect of the invention, a stent is placed with an inflation device. The inflation device may be a balloon that carries the stent, and placing the stent includes inserting the balloon and the stent within the passageway and inflating the balloon. A catheter may carry the balloon and the stent over the guide device.
In another embodiment of the present invention, the passageway is formed and the stent is placed by a catheter carrying a first inflation device and a second inflation device. The first inflation device may be a first balloon and the second inflation device may be a second balloon. The catheter is inserted over the guide device so that the first balloon is positioned in the location defined by the guide device. The first balloon is inflated to form the passageway and deflated after forming the passageway. The catheter then is further inserted over the guide device so that the second balloon is positioned in the passageway. The second balloon may carry a stent. The second balloon is inflated to place the stent within the passageway.
According to another aspect, the invention includes a method of providing direct blood flow between a heart chamber and a coronary vessel that includes inserting an inflation device through an anterior wall and a posterior wall of the coronary vessel and into the heart wall, inflating the inflation device within the heart wall to form a passageway between the heart chamber and the coronary vessel, and placing a stent within the passageway. Inserting the inflation device may include inserting the inflation device over a guide device extending between the heart wall and exterior the heart chamber and the coronary vessel.
Yet another aspect of the invention includes a device for measuring the depth of penetration from an anterior wall of a coronary vessel to a heart chamber. The device includes a hollow needle defining a lumen and having a distal end and a proximal end. A depth indication mechanism is disposed on an external surface of the hollow needle and a handle is disposed on the proximal end of the needle. The handle includes an inner portion in flow communication with the hollow needle and a portion of the handle is transparent so that blood from the left ventricle that enters the handle from the lumen of the needle can be observed.
According to yet another aspect of the invention, a device for placing a stent in a heart wall comprises a delivery tool configured to deliver the stent to a location within the heart wall and a stop mechanism disposed on the delivery tool such that the stop mechanism is proximate at least one end of the stent during delivery of the stent. The stop mechanism may be configured to engage a surface to determine the placement location of the stent within the heart wall.
According to another aspect, the invention includes a device for placement in a passageway between a heart chamber and a coronary vessel. The device includes a hollow conduit and a plurality of extensions protruding from an end of the conduit. The plurality of extensions can include a pair of extensions at opposite sides of the conduit.
The foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description, serve to explain the principles of the invention.
An aspect of the present invention includes a novel method of placing a stent within the heart wall between the left ventricle and the coronary artery to provide blood flow directly therebetween. The novel method generally includes the steps of establishing a position of a passageway between the left ventricle and the coronary artery, creating the passageway, and placing a stent in the passageway. Each of these general steps will be described in greater detail below.
Although the methods according to the invention will be described with reference to establishing direct blood flow between the left ventricle and left anterior descending coronary artery, connections between other heart structures and vessels to establish flow therebetween also are within the scope of the invention. In addition, the inventive methods may be used in other settings, aside from the heart, that require creating a passage or conduit and delivering a device into the created passage to establish direct flow communication between two volumes, especially between volumes that may be difficult to access.
Once implanted, conduit 12 extends from the posterior wall 14 of the coronary artery CA to the left ventricle LV. The posterior wall 14 refers to that portion of the arterial wall that interfaces with the heart wall. The anterior wall 16 of the coronary artery refers to a portion of the arterial wall that does not interface with the heart wall. In one preferred embodiment, conduit 12 lies substantially flush with the interface between posterior wall 14 of coronary artery CA and the exterior surface of heart wall HW surrounding left ventricle LV, as negative effects may result if conduit 12 protrudes into coronary artery CA or is recessed within the myocardium. For example, if conduit 12 protrudes too far into coronary artery CA, blood flow through coronary artery CA, as well as blood flow exiting conduit 12 may become disturbed, resulting in stasis. On the other hand, if conduit 12 is recessed within the myocardium such that a space remains between conduit 12 and posterior wall 14 of the CA, the space may become occluded with tissue, thereby preventing flow into CA.
The method according to an embodiment of the present invention includes forming a passage in the heart wall and implanting a conduit 12, preferably in the form of a collapsible stent, in the passage to establish direct flow communication between the left ventricular chamber and the left anterior descending coronary artery. In a preferred method of the present invention, a first step includes providing access to the location of the heart wall at which the stent 12 will be implanted. According to the invention, access to the heart wall surrounding the left ventricle LV is obtained from outside the coronary artery CA. A hollow needle 50, shown in
Insertion of the needle should avoid damaging or otherwise interfering with critical internal cardiac structures such as, for example, the papillary muscles, chordae, the mitral valve, etc. To avoid such damage, a visualization technique may be employed either prior to insertion of the needle or concurrently with the insertion of the needle. Such visualization techniques can include, for example, the use of transesophogeal, intraventricular, intracardiac, or epicardial ultrasonic probes, or a combination thereof.
In a preferred form of the invention, the stent 12 will be implanted at an angle in the heart wall. The angle of the stent 12 to the heart wall preferably is chosen according to fluid flow analyses that seek to optimize the blood flow path from the left ventricle to the coronary artery and minimize energy losses due to poor entry and exit angles, and the like. In the case of an angularly implanted stent, hollow needle 50 also will have to enter the heart wall at the appropriate angle. To properly angle hollow needle 50, a positioning tool preferably is employed. A preferred embodiment of such a positioning tool is shown in FIG. 2. Positioning tool 20 is a hollow tube preferably made of a substantially rigid material. Positioning tool 20 includes a first portion 22 connected to a second portion 24 at a hinge 26. First portion 22 has opposite ends 28, 30, and second portion 24 has an end 32 opposing end 30 and another end not shown in FIG. 2. In use, portion 22 is inserted into the coronary artery and portion 24 extends outside of the heart with end 32 open and facing towards the posterior wall of the coronary artery and the heart wall. The user bends portion 24 relative to portion 22 at hinge 26 so that portions 22 and 24 are at an appropriate angle. The user then can insert the hollow needle through portion 24 and into the heart wall at the desired angle.
After hollow needle 50 has punctured both the anterior and posterior walls of coronary artery CA, and has traversed the heart wall to enter into left ventricle LV, it may be desirable to measure the depth of penetration of the needle and thereby determine the thickness of the heart wall from the depth of needle penetration. This determination will be used later when, for example, choosing an appropriate balloon length for forming a passage between the left ventricle and the coronary artery, and choosing an appropriate length conduit to place in the passage. Therefore, on its external surface, the needle is provided with a depth indication mechanism. A preferable depth indication mechanism includes providing graduated markings representing various lengths on a proximal end of the needle. Once the needle penetrates through the ventricular wall and into the chamber, causing a reflux of blood through the needle, the depth of penetration is measured by the marking adjacent the anterior wall of the coronary artery. To then determine the thickness of the ventricular wall, the diameter of the coronary artery at the insertion site must be subtracted from the depth of needle penetration. This coronary artery diameter may be determined preoperatively by appropriate imaging techniques. Preferably, the preoperative image will show the location of the occlusion, the appropriate location for insertion of the needle, and the coronary artery diameter at that location.
An alternative depth indication mechanism includes an indicator 52 slidably disposed on needle 50. An example of such an indicator is shown in FIG. 4. Marker 52 defines an aperture through which needle 50 is inserted. The aperture preferably is sized such that marker 52 easily, yet controllably, slides along the length of the needle. That is, the aperture preferably is sized such that marker 52 frictionally engages with the needle and thus cannot slide along the needle unless a sufficient force is applied to the marker. Marker 52 abuts the anterior wall 16 of the coronary artery CA and slides along the length of the needle as the needle is inserted into the left ventricle LV. After needle 50 is removed, the depth of penetration is indicated by measuring the length from the distal end of needle 50 to marker 52. As a further alternative, graduated markings could be provided on the needle along with the marker to assist in determining the depth of penetration. Again, the actual thickness of the ventricular wall is determined by subtracting the diameter of the coronary artery (which preferably is determined using a visualization technique, such as echocardiography for example) from the depth of penetration measurement.
As a further alternative device and method for aiding the accurate determination of the depth of needle insertion, the needle may include a suitable pressure transducer at the tip of the needle. The pressure transducer would sense the pressure of the left ventricle to accurately indicate when the needle enters the left ventricle. Once such a pressure is indicated, the depth of penetration is determined by the graduated markings on the outside of the needle, as explained above.
After hollow needle 50 has been inserted through the coronary artery CA and heart wall, and into the left ventricle LV, such that a path having the desired angle and positioning relative to internal heart structures has been created, a guidewire 60 or other suitable guide device is placed within the lumen of hollow needle 50 and extended therethrough. The guidewire 60 preferably has a tip portion which is relatively flexible while the portion of the guidewire to be positioned in the myocardium preferably is relatively stiff. After the guidewire has been extended between the left ventricular chamber LV and external to the anterior wall of the coronary artery CA, the needle can be removed by sliding it off the guidewire. The placement of guidewire 60 allows a pathway to be maintained so that the myocardium and left ventricular chamber can be accessed from outside the heart.
The next step of an embodiment of the inventive method includes forming a passageway in the heart wall at the location in which stent 12 will be implanted. Preferably, the passageway will be formed using a dilation mechanism, and more preferably an inflatable dilation mechanism. The inflatable dilation mechanism can be positioned in the heart wall in a deflated configuration and then inflated to thereby dilate the heart wall, thus forming the passageway. A preferred inflatable dilation mechanism for forming such a passageway includes a balloon catheter 70, such as the one shown in FIG. 6. The balloon catheter can be fed over the guidewire with a dilation balloon 71 in a deflated condition. Thus, the catheter carrying a deflated dilation balloon advances through the anterior and posterior walls of the coronary artery and into the wall surrounding the left ventricle. The catheter may be inserted until balloon 71 resides within the heart wall. Preferably, the balloon has a length corresponding to approximately the thickness of the heart wall, and more preferably greater than or equal to the thickness of the heart wall, as measured during insertion of the hollow needle with either the measuring devices described above or through the use of utlrasound or the like. If the length of the balloon is greater than the thickness of the heart wall, the balloon may be positioned such that the excess length extends into the ventricle. The diameter of the inflated balloon is chosen so as to approximate the dimensions of the stent, for example diameter and length, that is desired in the heart wall. To facilitate positioning of the catheter, and in particular the balloon, with respect to the heart wall, a visualization technique, such as ultrasound or fluoroscopy, for example, or a mechanical mechanism, such as a mechanical stop, which may be formed by the balloon itself as will be explained shortly, may be utilized.
Once the catheter has been advanced such that dilation balloon 71 resides substantially within the heart wall, an inflation mechanism (not shown) is actuated to inflate the balloon. Balloon 71 is inflated as necessary to dilate the heart wall, causing a passageway to be formed therein, as shown in FIG. 6. The balloon preferably is made of a semi-compliant material to impart the appropriate dilation force to the heart wall. Preferably, the balloon will be inflated to a diameter corresponding to less than the maximum inflation extent of the balloon. This amount of inflation preferably will correspond to the desired dimensions, diameter and length, of the formed passageway. After dilating the heart wall and forming a passageway having desired dimensions, the balloon is deflated and removed from the passageway and the heart wall.
After removing the dilation balloon, the next step includes delivery of the stent into the as-formed passageway using a suitable delivery mechanism. In a preferred embodiment of this step, an inflatable delivery mechanism carrying the stent, such as a delivery balloon with stent 12 loaded thereon, is inserted into the passageway formed in the heart wall. Preferably, the balloon carrying the stent 12 is deflated and stent 12 is a collapsible stent that will be in a collapsed state when loaded onto the deflated delivery balloon. The stent 12 can be held in place on the delivery balloon by inflation pressure or other suitable mechanism.
As with dilation balloon 71, delivery balloon 76 (shown in
In an embodiment of the invention, the length of delivery balloon 76 exceeds the length of stent 12 while collapsed. Stent 12 may be loaded onto the delivery balloon such that the deflated delivery balloon extends beyond each end of stent 12, and preferably at least from the proximal end of stent 12. As a result of extending beyond both ends of the stent, the balloon can expand during deployment beyond the ends of stent 12 and attain a dumbbell-like shape. In this manner, as illustrated for example in
Other embodiments of the inventive method include using a sheath as a dilation mechanism to form the passageway in the heart wall and to deliver the catheter carrying the stent to the heart wall. In embodiments using a sheath, after positioning the guide device in the desired location in the heart wall, a sheath may be advanced over the guidewire and inserted through the coronary artery and heart wall. The sheath will dilate the heart wall to form the passageway. Graduated markings may be placed on the outside of the sheath to determine the depth of penetration in the heart wall. A stent to be delivered may be preloaded on a balloon catheter and inserted over the guidewire and through the sheath to the appropriate position in the heart wall.
In conjunction with this sheath delivery technique described above, various mechanisms, as shown for example in
After appropriate positioning of stent 12, a locking mechanism (not shown) on sheath 200 may be used to fix the position of catheter 132. Once stent 12 has been placed within the heart wall, sheath 200 and catheter 132 may be removed from the heart. To remove sheath 200, basket 133 first must be retracted or compressed.
Regardless of the delivery technique employed, stent 12 preferably will be selected such that, upon full expansion, the conduit will have dimensions that cause the passageway in the heart wall to remain open, thereby creating a permanent passageway between the left ventricle and the coronary artery. Moreover, stent 12 preferably will have a length that approximately equals or is greater than the thickness of the heart wall. More preferably, the length of stent 12 is large enough to allow a small end portion of stent 12 to reside in the left ventricular chamber in order to prevent invagination of the tissue around the opening of the stent. Even more preferably, the length of the stent may be chosen such that it covers the systolic depth of the heart wall measured from the posterior wall of the coronary artery to the inner surface of the left ventricular wall. This systolic depth may be determined using visualization techniques, such as echocardiography, for example. In any case, the length of the stent 12 to be used may be determined from the measurements of the heart wall determined previously, for example using the hollow needle, in combination with the determination of the coronary artery diameter using appropriate visualization techniques.
In addition, the stent preferably will be made of or coated internally with a material that prevents heart wall tissue, blood, and debris from prolapsing into the stent. Such a material may include a woven or a non-woven polymer that is compatible with blood and has low thrombogenicity, or other coatings to improve resistance to thrombus formation or tissue overgrowth. Coatings that enhance endothelial cell formation also are desired. Moreover, the stent may include a drug delivery coating. Other materials exhibiting these characteristics while also allowing deployment by the inventive method also are within the scope of the invention.
A further preferable feature of the stent to be implanted in the heart wall includes a flow controller disposed within the stent. Such a flow controller preferably would bias flow in the net forward direction, i.e., in the direction flowing from the ventricle to the coronary artery. Flow control mechanisms of this type include autologous vein sections, xenograft vein or valve sections, tilting disks, ball-in-cage valves, tapered shunt configurations, lobed duckbill flaps, mechanical poppets, pressure or electrically activated valves, and other suitable like mechanisms. Examples of various flow control mechanisms used with stents to create a net forward flow from the left ventricle to the coronary artery can be found in commonly-owned U.S. patent application Ser. No. 09/368,393, filed Aug. 4, 1999, and entitled "Valve Designs for Left Ventricular Conduits." The entire disclosure of that application is incorporated by reference herein.
In another embodiment of a flow controller, a stent may be used to create a natural valving mechanism to reduce the potential occurrence of backflow of blood from the coronary artery to the left ventricle during portions of the cardiac cycle, particularly diastole. This will be described in connection with
This placement of the stent, along with the struts 100, causes natural valving to occur, as described with reference to
Once stent 12 has been expanded and positioned in the passageway in the heart wall, the delivery balloon is deflated. The catheter carrying the delivery balloon can then be removed from the patient by sliding it over the guidewire. The guidewire also can be removed from the patient and the puncture site in the artery can be closed via conventional suturing methods and/or surgical sealants, or other suitable closure techniques and mechanisms. In certain embodiments, a closing device similar to those used and known to close a patent foramen ovale may be used. Also, the inner part of the closing device which covers the inner surface of the coronary artery may be constructed without any Dacron or covering material as long as the fixation of the closing device is maintained by suitable fixation members. An outer portion of the closing device, made for example of a biocompatible covering material like Dacron, may then be connected to the inner portion of the closing device to close the hole.
Alternatively, it may be possible to close the hole in the anterior wall of the artery by retracting the wall of the artery without any closing device. Such a technique would be similar to using a suture, but would not require assistance by the surgeon. For example, as the hole in the artery is formed by introducing a sheath over a wire, the tissue surrounding the hole is compressed around the sheath. After removing the sheath, this tissue will tend to cause a portion of the artery wall to retract to close the hole. To assist in this process, a small outer ring may be fixed to the outside surface of the artery. This outer ring may be formed of a suitable closure material, such as a suture or glue. The ring may be applied prior to removing the sheath, essentially using the outer surface of the sheath as an applicator. Once the ring is fixed to the outer surface of the coronary artery, the sheath may be removed. The ring may then retract the tissue surrounding the hole to close the hole in the coronary artery.
As discussed above, the steps of dilating the heart wall using a balloon catheter to form the passageway and implanting the conduit can be performed by using separate catheters for each step, a first catheter carrying the dilation balloon and a second catheter carrying the delivery balloon and stent. As an alternative, a single catheter carrying both a delivery balloon and a dilation balloon and stent in a collinear manner may be used. If two separate catheters are employed, one carrying the dilation balloon and one carrying the delivery balloon, a catheter exchange technique is employed. That is, after the catheter carrying the dilation balloon has been employed to form the passageway in the heart wall, the dilation balloon will be deflated and the catheter will be slid along the guidewire and removed from the patient. Then, the catheter carrying the delivery balloon with the collapsed stent loaded thereon is inserted over the guidewire and into the correct position with respect to the heart wall, and the conduit is implanted as described above.
If a single catheter carrying both the dilation and the delivery balloons is employed, the method is performed in the following manner.
In one aspect of the invention, the method includes using a multiple balloon stent delivery catheter of the type shown in
Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. The specification and examples are exemplary only, with a true scope and spirit of the invention being indicated by the following claims.
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|U.S. Classification
|128/898, 604/8, 623/1.11
|International Classification
|Cooperative Classification
|European Classification
|May 1, 2001
|May 31, 2005
|Certificate of correction
|Sep 20, 2005
|Certificate of correction
|Oct 3, 2006
Owner name: HORIZON TECHNOLOGY FUNDING COMPANY LLC, CONNECTICU
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PERCARDIA, INC.;REEL/FRAME:018375/0912
Effective date: 20060701
|Aug 25, 2008
|Maintenance fee reminder mailed
|Feb 15, 2009
|Lapse for failure to pay maintenance fees
|Apr 7, 2009
|Expired due to failure to pay maintenance fee
Effective date: 20090215


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Photo SpecialBrad: The Superdad!
Pitt is one hands-on dad! See how the father of four enjoys family time around the world with Maddox, Pax, Zahara and Shiloh. By Julia Wang
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water treatment Equipment in Alabama
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Adults must be accompanied by a child to visit the LEGOLAND Discovery Center.
To ensure our guests have the best experience possible, we have limited the number of visitors that can be in the Center at one time. All guests buying tickets online OR at the door will be required to make a reservation for an entry time.
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Please note: coupons can not be combined with online ticket sales. Tickets must be purchased online before your visit day to benefit from the online discount.
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Next event: Monday, September 28, 7 p.m. to 9 p.m.*
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Ticket includes Priority Access for our Adult night program for LEGOLAND® Discovery Center Dallas Fort Worth.
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Adults must be accompanied by a child to visit the LEGOLAND Discovery Center.
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Open from 10 a.m. Sunday - Friday (9 a.m. on Saturday)
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I took my granddaughter who was visiting to LEGOLAND yesterday and she had the time of her life. Word to the wise, don't just walk up to try to get in I heard folks doing that around in the afternoon and they were sold out for the rest of the day. It is also more expensive to walk up. Go to the internet and buy your tickets ahead of time, Simple process. That way you have a reservation for an exact time and you pay less.
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text:
ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, March 3, 2008 Max Planck Moves Stateside
This story will be available on March 3 at [http://pubs.acs.org/cen/coverstory/86/8609cover.html]
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Journalists Resources
Save the Date: News Media Special Event April 7 in New Orleans
The 2008 edition of the ACS Office of Communications popular news media tour/briefing/reception heads for a premier research facility where science connects with everyday life. Reporters will visit the U. S. Department of Agricultures Southern Regional Research Center (SRRC) in New Orleans. After recovery from Hurricane Katrinas devastation, SRRC is continuing a 66-year heritage of discovery. SRRCs landmarks range from development of wrinkle-resistant cotton fabrics to battling the dreaded Formosan subterranean termite in the Second Battle of New Orleans. The event begins mid-afternoon on April 7 during the ACS 235th national meeting. Stay tuned for details and registration information.
Media registration for ACS National Meeting in New Orleans, April 6-10
Mark your calendars for one of the years largest and most important scientific events the 235th National Meeting and Exposition of the American Chemical Society (ACS), which will be held April 6-10, 2008, in New Orleans, La. With more than 160,000 members in the United States and other countries, ACS is the worlds largest scientific society. About 12,000 scientists and others are expected for the event, which will include more than 9,000 reports on new discoveries in chemistry. Those reports span sciences horizons from astronomy to zoology and include a sp
|Contact: Michael Woods
American Chemical Society