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$300 Fearsome Siberian Husky PuppiesSiberian Husky · Elyria, OH… Available. text or call for more info at 614 x 452 x 9107Alice B. · 2 hours ago
$500 411 Ac Bbeckoning male and female Alaskan Malamute PuppiesAlaskan Malamute · East Cleveland, OHBbeckoning male and female Alaskan Malamute Puppies. They are currently 13 weeks old and is up to date on their shots.Alaskan Malamute Pu...Aarushi B. · 3 days ago
$450 Phjaeg Home raised Teacup Yorkie PuppiesYorkshire Terrier · Akron, OH… Our puppies are raised with lots of TLC. Raised in our home. They are healthy, happy quality pup...Debra P. · 4 days ago
Down and charming , good, adorable, honest boston terrier puppiesBoston Terrier · Brecksville, OHAll of our beautiful boston terrier puppies have found homes. If you are interested in them get to us now asap for more info please call ...Nelly G. · 5 days ago
$800 Cane Corso PupsCane Corso · Cleveland, OHI currently have five cane corso puppies left. The sire and dam both have champion bloodlines. I have a formation, a black brindle and th...Cora R. · 6 days ago
$1,000 AKC German Shepherd Puppies, Import LinesGerman Shepherd · Newton Falls, OHI currently have a litter of 9 puppies that will be available at 8 weeks October 18th. There are currently 6 available- 1 bicolor blk/red...Brittany K. · 1 week ago
$800 AKC white male. Green Acre's Prince of IcelandPomeranian · Orrville, OHHandsome friendly male Pomeranian with amazing AKC pedigree. 8 months.Dave C. · 1 week ago
$700 Talking Congo African Greys, Male & FemaleAfrican Grey Parrot · Brunswick, OHMore info text us.(214) 307-XXXX or go to our website at WWW.WHPMC.COM. Beautiful, talkative pair, tame and sociable with kids. They are ...Lilian H. · 2 weeks ago
$1,100 AKC Long Coat German Shepherd PupsGerman Shepherd · Canton, OHWe currently have a long coat AKC litter of 8 wk old. beautiful German Shepherd Pups (ONLY 3 boys NOW Available on September 15th. /READY...Lori E. · 3 weeks ago
$400 8 week old shih tzu puppyShih-Tzu · Elyria, OHI bought her from a breeder a few days ago and my pug is being way to aggressive with her. I bought her for $400 so that's what I'm rehom...Mercedes S. · 3 weeks ago
$700 AKC German Shepherd Puppies 11 wks old ( REDUCED )German Shepherd · Warren, OHMother is American Show Lines , Father Is European Show Lines... Black/Red. Born: 7/20/15. Have First Shots &; wormed (($ 600 Males )) ((...Sierra S. · 3 weeks ago
$300 .Akc registered and healthy Boston terrierBoston Terrier · Uniontown, OH..Akc registered and healthy Boston terrier Hello, Yes we have a stunning litter of French bulldog puppies which are ready for their new...Andy C. · 4 weeks ago
Adopt Sonny a BoxerBoxer · Elyria, OHWonderful Sonny here! He's a 5 mnth old attractive brindle Boxer mixture. Sonny was rescued from a high kill shelter and hopes to find a ...Sonny ·58 minutes ago on Petfinder.comTools
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text: Little Fockers Trailer by Hilton Hater at December 16, 2010 5:51 am. Comments Are you a fan of obvious, immature humor? If so, as previewed here, Little Fockers is the comedy for you! This video is no longer available. Please check below for related videos. Edit Delete Follow The Hollywood Gossip? Facebook Disqus Uploaded by: Hilton Hater Uploaded: December 16, 2010 Duration: 107 seconds

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LIZ JONES: 'I hate to say it, but Posh has proved she's the real deal...' Our startled style guru on Victoria Beckham's collection
Late on Saturday, Victoria Beckham tweeted that she was working until dawn to get Sunday morning's collection ready.
I'm not surprised she went without sleep. Her new collection, unveiled that freezing Sunday morning in New York, had a lot to live up to.
Her last collection, for spring/summer 2013, had been her best to date: perfectly constructed cocktail dresses in wool and silk, nudes and black, with integral corsetry and sheer panels.
Topped herself: Her last collection, for spring/summer 2013, had been her best to date...who could top that? Only her
Gorgeous buttery boots that also were part flip-flop. Great use of colour, such as vivid orange in a maxi skirt and a jacket.
Who on earth could top that? A collection that even I named the absolute best of the season, and which was a hit in every sense of the word.
Even though her spring/summer clothes have only just started to trickle into stores (Harrods, Selfridges ) and on to sites such as Net-a-Porter and mytheresa.com, the key pieces have already sold out.
She's done it again: Oh, the chocolate brown, the burnt sienna, the purple the exact colour of Scottish heather just seem so delicious, so right, so new
New on the scene: It's easy to forget she has only been designing clothes since 2008
But was that collection a fluke, a one off? Could she do it again?
Well, I hate to say this — having been one of her fiercest critics — but she has trumped herself, and then some.
More from Liz Jones for The Mail on Sunday...
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the chocolate brown, the burnt sienna, the purple the exact colour of
Scottish heather just seem so delicious, so right, so new.
The dominant length, too — an assured mid-calf midi — makes any other skirt seem suddenly wrong, and gauche.
She has moved away, too — and we never thought she would — from the super-tight, body-conscious dress.
You know, the sort of gown that shows your kidneys, made famous by Roland Mouret and beloved of Hollywood starlets on the red carpet. Instead, she has offered up cocktail frocks that are wrapped and draped in a way that is grown-up and subtle.
My only criticism of the draping, asymmetry and slightly 'felty' fabric in the dresses on show on Sunday morning is that they will make anyone over a size ten feel a bit bulky — and anyone over the age of 40 a tad frumpy.
But then, VB is not designing for women who are anything other than those fashioned in her own image.
And for a woman who for her first few seasons shied away from tailoring, her trousers, which skim the ankle (all the better to show off the many pointy Mary Janes and pixie boots on offer), and jackets, with their slouchy shoulders and low lapels, are really well executed.
It's easy to forget she has only been designing clothes since 2008.
The reason these midi skirts, wrap dresses and pointy hems work is that — given they all have splits, key holes and slashes to the waist — they are still unabashedly sexy. Which is, after all, exactly what women want.
There is more than enough in this collection for the high-flying female executive to salivate over, but I'd have liked more overcoats (her olive military coats last winter were fabulously warm), and I'm not keen on the pony skin bomber jacket.
But these are minor quibbles, mere pin pricks in the side of a brand that is poised to break into the big time with the imminent launch of her own website, victoriabeckham.com.
The site will sell her clothes, giant totes — there were loads of these monsters on show on Sunday; I pitied the poor models who had to hug them, given the lack of muscle definition in their arms — shoes, denim, sunglasses et al direct.
Brand Beckham: Her fashion brand is co-owned by husband David (present in the front row at the show, alongside Anna Wintour) and Simon Fuller
Her fashion brand is co-owned by husband David (present in the front row at the show, alongside Anna Wintour) and Simon Fuller, the music impresario.
I imagine all three now have dollar signs instead of irises, given the fact that other key luxury brands, such as Dior, Prada and Stella McCartney, lag behind so much when it comes to online sales, with their antiquated websites.
My favourite piece in the entire collection is a tuxedo jacket with severe shoulders, worn like a cape, with the arms slashed open, as if the wearer has just had a run-in with Freddy Krueger.
The simple evening shifts with contrasting bodices — all bound to hover at the £2,000 mark; her prices seem to escalate every season — even make her spring/summer corset dresses seem slightly old hat.
Long night: I'm not surprised she went without sleep. Her new collection had a lot to live up to... and it just about did
Should we care about a collection that very few of us can afford? Well, come August we can expect the High Street to be awash with copycat kitten heels, sloppy pixie boots, apron dresses and monkish brown tunics cinched with Sam Brown belts.
Victoria Beckham has been the most Googled and tweeted about designer throughout New York Fashion Week. That she has been able, in such a few short years, to trump Calvin Klein for minimal elegance, Michael Kors for luxury, Oscar de la Renta for top-notch fabrics and even Miuccia Prada for new ideas is nothing short of remarkable.
She has even thrown down a gauntlet (maybe her website will sell gloves, too?) to Burberry, who will show in London next week — her plaid coat, dipped in shiny royal-blue skirting, makes Christopher Bailey's over-embellished trench coats and biker jackets seem gaudy.
My only wish is that VB will think about showing in London next season.
Who'd have thought: a former girl-band member with bad skin, the toast of the snooty fashion world. I'm still choking on the feathers from the Philip Treacy hat I've been munching on since last September.
All in all, VB equals VG. You can't say fairer than that.
After Victoria Beckham's show for spring/summer 2013, I've longed to snap up the black cocktail dress with sheer décolletage.
I signed up for an email alert at MyTheresa.com.
On Sunday, I received one. I logged on. There was my dress! I paid £1,850.
'Your dress has been dispatched!' said the email. On Monday, I got another.
'We need you to scan your passport and the back of your credit card, and fax or email the documents to us.'
I called them. I listened to a recorded voice for 33 minutes.
Finally, someone answered. I told her I don't have a scanner or printer so can't do as they ask.
'Do you have a friend with a scanner?' 'No!' 'Then we can't process the transaction.'
I slammed the phone down. 0/10
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Henry Somerset, 2nd Duke of Beaufort
2 of 3 portraits of Henry Somerset, 2nd Duke of Beaufort
© National Portrait Gallery, London
Henry Somerset, 2nd Duke of Beaufort
by George Vertue, after Michael Dahl
engraving, 1714
17 3/8 in. x 11 7/8 in. (442 mm x 301 mm) paper size
Purchased with help from the Friends of the National Libraries and the Pilgrim Trust, 1966
Reference Collection
Click on the links below to find out more:
Sitterback to top
- Henry Somerset, 2nd Duke of Beaufort (1684-1714), Tory politician. Sitter in 3 portraits.
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- Michael Dahl (1659-1743), Portrait painter. Artist associated with 167 portraits, Sitter in 2 portraits.
- George Vertue (1683-1756), Engraver and antiquary. Artist associated with 851 portraits, Sitter in 7 portraits.
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Publications (95)372.8 Total impact
Article: Acute high frequency stimulation of the prefrontal cortex or nucleus accumbens does not increase hippocampal neurogenesis in rats[Show abstract] [Hide abstract]
ABSTRACT: To date, the effects of deep brain stimulation (DBS) on hippocampal neurogenesis have been mainly characterized in the context of memory. Acute stimulation (i.e. for 1 h) of either the entorhinal cortex or the anterior thalamus increases both cell proliferation and survival. We investigate whether stimulation applied to targets being considered for the treatment of depression, namely the ventromedial prefrontal cortex (vmPFC) or nucleus accumbens (Acb), also increases hippocampal neurogenesis in rodents. Rats were treated with vmPFC or Acb DBS for 1 h at different settings. 5'-bromo-2'deoxyuridine (BrdU) was injected three days following stimulation onset and animals were sacrificed 24 h or 28 days later. Overall, we found that neither vmPFC nor Acb DBS increased hippocampal neurogenesis. In summary, the delivery of acute stimulation into targets homologous to those used in human depression trials does not increase hippocampal neurogenesis. Copyright © 2015 Elsevier Ltd. All rights reserved.Journal of Psychiatric Research 09/2015; 68:27-29. DOI:10.1016/j.jpsychires.2015.05.012 · 3.96 Impact Factor
Article: Using a maternal immune stimulation model of schizophrenia to study behavioral and neurobiological alterations over the developmental course[Show abstract] [Hide abstract]
ABSTRACT: A growing body of evidence sheds light on the neurodevelopmental nature of schizophrenia with symptoms typically emerging during late adolescence or young adulthood. We compared the pre-symptomatic adolescence period with the full symptomatic period of adulthood at the behavioral and neurobiological level in the poly I:C maternal immune stimulation (MIS) rat model of schizophrenia. We found that in MIS-rats impaired sensorimotor gating, as reflected in disrupted prepusle inhibition (PPI), emerged post-pubertally, with behavioral deficits being only recorded in adulthood but not during adolescence. Using post mortem HPLC we found that MIS-rats show distinct dopamine and serotonin changes in the medial prefrontal cortex (mPFC), nucleus accumbens (Nacc), caudate putamen, globus pallidus, and hippocampus. Further, FDG-PET has shown that these animals had lower glucose uptake in the ventral hippocampus and PFC and a higher metabolism in the amygdala and Nacc when compared to controls. Changes in neurotransmission and metabolic activity varied across brain structures with respect to first appearance and further development. In the mPFC and Hipp, MIS-rats showed abnormal neurochemical and metabolic activity prior to and with the development of behavioral deficits in both adolescent and adult states, reflecting an early impairment of these regions. In contrast, biochemical alteration in the Nacc and globus pallidus developed as a matter of age. Our findings suggest that MIS-induced neurochemical and metabolic changes are neurodevelopmental in nature and either progressive or non-progressive and that the behavioral deficits manifest as these abnormalities increase. Copyright © 2015 Elsevier B.V. All rights reserved.Schizophrenia Research 06/2015; 166(1-3). DOI:10.1016/j.schres.2015.05.010 · 3.92 Impact Factor
Article: Altered local field potential activity and serotonergic neurotransmission are further characteristics of the Flinders sensitive line rat model of depression[Show abstract] [Hide abstract]
ABSTRACT: A significant portion of patients suffering from major depression remain refractory to available antidepressant treatment strategies. This highlights the need for a better understanding of the underlying neuropathology in order to develop rationale-based treatments. Here we aimed to further characterize neurobiological abnormalities of the Flinders Sensitive Line (FSL) rat model of depression. Biochemically, in FSL rats we mainly found increased levels of serotonin in most cortical and subcortical brain regions when compared to controls. Using electrophysiological measurements, in FSL rats we found decreased alpha, beta and low gamma oscillatory activity in the medial prefrontal cortex and nucleus accumbens and decreased alpha and beta as well as increased low gamma oscillatory activity in the subthalamicus nucleus when compared to controls. In summary, we show distinct neurochemical properties in combination with particular oscillatory activity patterns for brain areas thought to be pathophysiologically relevant for depression. Our data contribute to the further understanding of neurobiological alterations in the FSL rat model of depression that could provide a basis for research into future therapeutic strategies. Copyright © 2015 Elsevier B.V. All rights reserved.Behavioural brain research 05/2015; 291. DOI:10.1016/j.bbr.2015.05.027 · 3.03 Impact Factor
Article: Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease[Show abstract] [Hide abstract]
ABSTRACT: Mesenchymal stem cells (MSC) are easily harvested, and possess anti-inflammatory and trophic properties. Furthermore, MSC promote neuroprotection and neurogenesis, which could greatly benefit neurodegenerative disorders, such as Parkinson's disease. MSC were transplanted one week after 6-hydroxydopamine lesioning and effects were evaluated after 6 months. MSC localized around the substantia nigra and the arachnoid mater, expressing pericyte and endothelial markers. MSC protected dopamine levels and upregulated peripheral anti-inflammatory cytokines. Furthermore, adipose-derived MSC increased neurogenesis in hippocampal and subventricular regions, and boosted memory functioning. Considering that hyposmia and loss of memory function are two major nonmotor symptoms in Parkinson's disease, transplants with modulatory effects on the hippocampus and subventricular zone could provide a disease-modifying therapy.Regenerative Medicine 05/2015; 10(4):431-46. DOI:10.2217/rme.15.17 · 2.79 Impact Factor
Article: Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System[Show abstract] [Hide abstract]
ABSTRACT: In recent years, deep brain stimulation (DBS) has emerged as a promising treatment option for patients suffering from treatment-resistant depression (TRD). Several stimulation targets have successfully been tested in clinical settings, including the subgenual cingulum (Cg25) and the medial forebrain bundle (MFB). MFB-DBS has led to remarkable results, surpassing the effect of previous targets in terms of response latency and number of responders. However, the question remains as to which mechanisms underlie this difference. The aim of the present study was to thoroughly study the anti-depressant effect of MFB-DBS in the Flinders sensitive line (FSL) rat model of depression as well as to investigate whether MFB-DBS and Cg25-DBS operate through the same neurobiological circuits. FSL and control rats received bilateral high-frequency stimulation to the MFB at the level of the lateral hypothalamus, while being subjected to a variety of depression- and anxiety-related behavioral paradigms. To further compare the effects of MFB-DBS and Cg25-DBS on reward-related behavior, animals were stimulated in either the MFB or ventromedial prefrontal cortex (vmPFC, rodent analog to Cg25), while being tested in the intra-cranial self-stimulation paradigm. A marked symptom-specific anti-depressant effect of MFB-DBS was demonstrated. The ICSS-paradigm revealed that MFB-DBS, as opposed to vmPFC-DBS interacts with the reward system. Our data suggest that MFB-DBS and Cg25-DBS do not operate via the same neurobiological circuits. This differentiation might be of interest when selecting patients for either Cg25- or MFB-DBS. Copyright © 2015 Elsevier Inc. All rights reserved.Brain Stimulation 02/2015; 8(4). DOI:10.1016/j.brs.2015.02.009 · 4.40 Impact Factor
Article: Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue[Show abstract] [Hide abstract]
ABSTRACT: Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT), which is involved in neuro-transmitter analysis. Using the MTHFR-deficient mouse model the purpose of this study was to investigate levels of monoamine neurotransmitters and amino acid levels in brain tissue. MTHFR deficiency affected levels of both glutamate and γ-aminobutyric acid in within the cerebellum and hippocampus. Mthfr −/− mice had reduced levels of glutamate in the amygdala and γ-aminobutyric acid in the thalamus. The excitatory mechanisms of homocysteine through activation of the N-methyl-D-aspartate receptor in brain tissue might alter levels of glutamate and γ-aminobutyric acid.Molecular Genetics and Metabolism 02/2015; 3:1-4. DOI:10.1016/j.ymgmr.2015.02.001 · 2.63 Impact Factor
Conference Paper: DAT-overexpressing rats - a new animal model for repetitive behavior?DGPPN; 11/2014
Article: Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning[Show abstract] [Hide abstract]
ABSTRACT: Background aims: In Parkinson's disease (PD), neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) axis is affected as the result of the lack of dopaminergic innervations reaching the SVZ. This aberrant network has been related to the hyposmia of PD patients, which is an early diagnostic marker of the disease. Consequently, much interest arose in finding mechanisms to modulate the SVZ-OB axis. Direct modulation of this axis could be achieved by transplantation of mesenchymal stromal cells (MSC), as it has been shown in rat and mouse PD models. However, the neurogenic effect of MSC in PD was thus far only analyzed weeks after transplantation, and little is known about effects immediately after transplantation. Methods: We assessed the acute neuroprotective and neurogenic effects of adipose-derived MSC transplanted into the rat substantia nigra in the 6-hydroxydopamine model of PD. Results: Three days after transplantation, subventricular neurogenesis was significantly increased in MSC-transplanted versus non-transplanted animals. Most MSC were found in the region of the substantia nigra and the surrounding arachnoid mater, expressing S100β and brain-derived neurotrophic factor, whereas some MSC showed an endothelial phenotype and localized around blood vessels. Conclusions: The acute neurogenic effects and neurotrophic factor expression of MSC could help to restore the SVZ-OB axis in PD.Cytotherapy 10/2014; 17(2). DOI:10.1016/j.jcyt.2014.09.005 · 3.29 Impact Factor
Article: Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance[Show abstract] [Hide abstract]
ABSTRACT: The acquisition of language and speech is uniquely human, but how genetic changes might have adapted the nervous system to this capacity is not well understood. Two human-specific amino acid substitutions in the transcription factor forkhead box P2 (FOXP2) are outstanding mechanistic candidates, as they could have been positively selected during human evolution and as FOXP2 is the sole gene to date firmly linked to speech and language development. When these two substitutions are introduced into the endogenous Foxp2 gene of mice (Foxp2(hum)), cortico-basal ganglia circuits are specifically affected. Here we demonstrate marked effects of this humanization of Foxp2 on learning and striatal neuroplasticity. Foxp2(hum/hum) mice learn stimulus-response associations faster than their WT littermates in situations in which declarative (i.e., place-based) and procedural (i.e., response-based) forms of learning could compete during transitions toward proceduralization of action sequences. Striatal districts known to be differently related to these two modes of learning are affected differently in the Foxp2(hum/hum) mice, as judged by measures of dopamine levels, gene expression patterns, and synaptic plasticity, including an NMDA receptor-dependent form of long-term depression. These findings raise the possibility that the humanized Foxp2 phenotype reflects a different tuning of corticostriatal systems involved in declarative and procedural learning, a capacity potentially contributing to adapting the human brain for speech and language acquisition.Proceedings of the National Academy of Sciences 09/2014; 111(39). DOI:10.1073/pnas.1414542111 · 9.67 Impact Factor
Article: Social experience modulates ocular dominance plasticity differentially in adult male and female mice[Show abstract] [Hide abstract]
ABSTRACT: Environmental factors have long been known to regulate brain plasticity. We investigated the potential influence of social experience on ocular dominance plasticity. Fully adult female or male mice were monocularly deprived for four days and kept a) either alone or in pairs of the same sex and b) either in a small cage or a large, featureless arena. While mice kept alone did not show ocular dominance plasticity, no matter whether in a cage or in an arena, paired female mice in both environmental conditions displayed a shift of ocular dominance towards the open eye. Paired male mice, in contrast, showed no plasticity in the cage, but a very strong ocular dominance shift in the arena. This effect was not due to increased locomotion, since the covered distance was similar in single and paired male mice in the arena, and furnishing cages with a running wheel did not enable ocular dominance plasticity in cage-housed mice. Confirming recent results in rats, the plasticity-enhancing effect of the social environment was shown to be mediated by serotonin. Our results demonstrate that social experience has a strong effect on cortical plasticity that is sex-dependent. This has potential consequences both for animal research and for human education and rehabilitation.NeuroImage 08/2014; 103. DOI:10.1016/j.neuroimage.2014.08.040 · 6.36 Impact Factor
Article: Human adipose-Derived Mesenchymal Stem Cells Improve Motor Functions and are Neuroprotective in the 6-Hydroxydopamine-Rat Model for Parkinson's Disease when Cultured in Monolayer Cultures but Suppress Hippocampal Neurogenesis and Hippocampal Memory Function when Cultured in Spheroids[Show abstract] [Hide abstract]
ABSTRACT: Adult human adipose-derived mesenchymal stem cells (MSC) have been reported to induce neuroprotective effects in models for Parkinson´s disease (PD). However, these effects strongly depend on the most optimal application of the transplant. In the present study we compared monolayer-cultured (aMSC) and spheroid (sMSC) MSC following transplantation into the substantia nigra (SN) of 6-OHDA lesioned rats regarding effects on the local microenvironment, degeneration of dopaminergic neurons, neurogenesis in the hippocampal DG as well as motor and memory function in the 6-OHDA-rat model for PD. aMSC transplantation significantly increased tyrosine hydroxylase (TH) and brain-derived neurotrophic factor (BDNF) levels in the SN, increased the levels of the glial fibrillary acidic protein (GFAP) and improved motor functions compared to untreated and sMSC treated animals. In contrast, sMSC grafting induced an increased local microgliosis, decreased TH levels in the SN and reduced numbers of newly generated cells in the dentate gyrus (DG) without yet affecting hippocampal learning and memory function. We conclude that the neuroprotective potential of adipose-derived MSC in the rat model of PD crucially depends on the applied cellular phenotype.Stem Cell Reviews and Reports 08/2014; 11(1). DOI:10.1007/s12015-014-9551-y · 2.77 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Vagal afferents are an important neuronal component of the gut-brain axis allowing bottom-up information flow from the viscera to the CNS. In addition to its role in ingestive behavior, vagal afferent signaling has been implicated modulating mood and affect, including distinct forms of anxiety and fear. Here, we used a rat model of subdiaphragmatic vagal deafferentation (SDA), the most complete and selective vagal deafferentation method existing to date, to study the consequences of complete disconnection of abdominal vagal afferents on innate anxiety, conditioned fear, and neurochemical parameters in the limbic system. We found that compared with Sham controls, SDA rats consistently displayed reduced innate anxiety-like behavior in three procedures commonly used in preclinical rodent models of anxiety, namely the elevated plus maze test, open field test, and food neophobia test. On the other hand, SDA rats exhibited increased expression of auditory-cued fear conditioning, which specifically emerged as attenuated extinction of conditioned fear during the tone re-exposure test. The behavioral manifestations in SDA rats were associated with region-dependent changes in noradrenaline and GABA levels in key areas of the limbic system, but not with functional alterations in the hypothalamus-pituitary-adrenal grand stress. Our study demonstrates that innate anxiety and learned fear are both subjected to visceral modulation through abdominal vagal afferents, possibly via changing limbic neurotransmitter systems. These data add further weight to theories emphasizing an important role of afferent visceral signals in the regulation of emotional behavior.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 05/2014; 34(21):7067-76. DOI:10.1523/JNEUROSCI.0252-14.2014 · 6.34 Impact Factor
Article: Corrigendum to "Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia" [Brain Behav. Immun. 38 (2014) 175–184][Show abstract] [Hide abstract]
ABSTRACT: Adult neurogenesis in the hippocampus is impaired in schizophrenic patients and in an animal model of schizophrenia. Amongst a plethora of regulators, the immune system has been shown repeatedly to strongly modulate neurogenesis under physiological and pathological conditions. It is well accepted, that schizophrenic patients have an aberrant peripheral immune status, which is also reflected in the animal model. The microglia as the intrinsic immune competent cells of the brain have recently come into focus as possible therapeutic targets in schizophrenia. We here used a maternal immune stimulation rodent model of schizophrenia in which polyinosinic-polycytidilic acid (Poly I:C) was injected into pregnant rats to mimic an anti-viral immune response. We identified microglia IL-1β and TNF-α increase constituting the factors correlating best with decreases in net-neurogenesis and impairment in pre-pulse inhibition of a startle response in the Poly I:C model. Treatment with the antibiotic minocycline (3mg/kg/day) normalized microglial cytokine production in the hippocampus and rescued neurogenesis and behavior. We could also show that enhanced microglial TNF-α and IL-1β production in the hippocampus was accompanied by a decrease in the pro-proliferative TNFR2 receptor expression on neuronal progenitor cells, which could be attenuated by minocycline. These findings strongly support the idea to use anti-inflammatory drugs to target microglia activation as an adjunctive therapy in schizophrenic patients.Brain Behavior and Immunity 05/2014; 46. DOI:10.1016/j.bbi.2014.01.019 · 5.89 Impact Factor
Conference Paper: Dopaminergic mechanisms of Obsessive Compulsive Spectrum Disorders studied in three pharmacological rat models of dopaminergic dysregulationDGPPN; 11/2013
Article: Anti-Anhedonic Effect of Deep Brain Stimulation of the Prefrontal Cortex and the Dopaminergic Reward System in a Genetic Rat Model of Depression: An Intracranial Self-Stimulation Paradigm Study[Show abstract] [Hide abstract]
ABSTRACT: One of the two core symptoms of major depression (MD), whether uni- or bipolar, is the inability to experience pleasure, suggested to be triggered by dysregulation within the brain reward system. In recent years, deep brain stimulation (DBS) has evolved as a potential tool to modulate pathological neural activity; stimulation of the subgenual cingulate (Cg25) has been shown to reduce depressive symptoms, including anhedonia. In rodents, the ventromedial prefrontal cortex (vmPFC) is likely to represent the correlate of Cg25 and accordingly, stimulation of vmPFC reduces anhedonia-like behavior in rats. The present study addresses the question of whether the anti-anhedonic effect of vmPFC-DBS is mediated by the brain reward system. Rats of the Flinders Sensitive Line (FSL), a validated genetic animal model of depression, and its controls, the Flinders Resistant Line (FRL), were stimulated in the vmPFC and tested in the forced swim test (FST), sucrose consumption test (SCT) and the intracranial self-stimulation (ICSS) paradigm. The curve-shift paradigm of ICSS was used in combination with vmPFC-DBS, d-amphetamine and fluoxetine to quantify reward-facilitating or -attenuating treatment effects. Our findings support anti-depressive efficacy of vmPFC-DBS with respect to despair- and anhedonia-like behavior, as shown in the FST and SCT, respectively. However, DBS did not elicit reward-facilitating or reward-attenuating effects on ICSS behavior. These data suggest that it is unlikely that the anti-anhedonic effect of vmPFC-DBS depends on the mesolimbic dopaminergic reward system.Brain Stimulation 10/2013; 7(1). DOI:10.1016/j.brs.2013.09.002 · 4.40 Impact Factor
Article: P.4.e.005 Dopaminergic mechanisms of obsessive compulsive spectrum disorders in two pharmacological rat models of dopaminergic dysregulationEuropean Neuropsychopharmacology 10/2013; 23:S527. DOI:10.1016/S0924-977X(13)70836-8 · 4.37 Impact Factor
Article: S.17.02 Modulating animal behaviour with deep brain stimulation – an approach for hypothesis development for deep brain stimulationEuropean Neuropsychopharmacology 10/2013; 23:S137. DOI:10.1016/S0924-977X(13)70189-5 · 4.37 Impact Factor
Article: Prenatal human influenza viral infection and brain disorder in mouse: Relevance for genesis of schizophreniaNeurotoxicology and Teratology 05/2013; 37. DOI:10.1016/j.ntt.2013.03.012 · 2.76 Impact Factor
Article: Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice[Show abstract] [Hide abstract]
ABSTRACT: Prenatal infection and exposure to traumatizing experiences during peripuberty have each been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for the cumulative impact of such prenatal and postnatal environmental challenges on brain functions and vulnerability to psychiatric disease. Here, we show in a translational mouse model that combined exposure to prenatal immune challenge and peripubertal stress induces synergistic pathological effects on adult behavioral functions and neurochemistry. We further demonstrate that the prenatal insult markedly increases the vulnerability of the pubescent offspring to brain immune changes in response to stress. Our findings reveal interactions between two adverse environmental factors that have individually been associated with neuropsychiatric disease and support theories that mental illnesses with delayed onsets involve multiple environmental hits.Science 03/2013; 339(6123):1095-9. DOI:10.1126/science.1228261 · 33.61 Impact Factor
Article: Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive–compulsive disorder[Show abstract] [Hide abstract]
ABSTRACT: The underlying neurobiology of addictive or repetitive behaviours, such as obsessive-compulsive disorder (OCD), involves dopaminergic dysregulation. While addictive behaviour depends strongly on mesolimbocortical dopaminergic responses, repetitive behaviours have been associated with dopaminergic dysregulation in the basal ganglia-thalamo-cortical circuitry. The present study investigates differences in brain stimulation reward in rats with quinpirole-induced compulsive checking behaviour, in order to examine if deficits in reward processing are also relevant for OCD. Rats were tested in the intracranial self-stimulation (ICSS) paradigm, which targets reward-related responses. After phenotype induction, animals were implanted with a monopolar stimulation electrode in the left medial forebrain bundle and trained to press a lever to self-administer electric stimulation of varying frequency. The curve-shift method was used to assess the reward-facilitating effects of d-amphetamine and the reward-attenuating effects of haloperidol (a D2 antagonist). Thresholds for ICSS were estimated before and after drug/saline injection. The reward-facilitating effects of d-amphetamine were enhanced in quinpirole-treated rats in comparison to controls. This finding suggests that chronic quinpirole-treatment induces changes within the reward circuitry relevant for compulsive behaviour in the rat.The International Journal of Neuropsychopharmacology 10/2012; 16(05):1-9. DOI:10.1017/S1461145712000983 · 4.01 Impact Factor
Top Journals
Technische Universität Dresden
Dresden, Saxony, Germany
- • Faculty of Medicine Carl Gustav Carus
- • Institute and Outpatient Clinics of Psychiatrics and Psychotherapy
Carl Gustav Carus-InstitutPforzheim, Baden-Württemberg, Germany
Charité Universitätsmedizin Berlin
Berlín, Berlin, Germany
- • Department of Psychiatry and Psychotherapy
- • Department of Psychiatry
- • Department of Nephrology
Humboldt-Universität zu BerlinBerlín, Berlin, Germany


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|Reviews for Love and Letting Go
| hmmm chapter 52 . 2/15
nice and stuff... but what about Henry? You neglected the poor boy dreadfully. ;)
| hmmm chapter 44 . 2/15
I get a feeling you enjoy writing peaceful family life ;) You bring up all these great conflicts and then deal with them waaay to quickly, for my taste.
| hmmm chapter 43 . 2/15
Finally something going on again. It was a bit boring with Ted being so good all of a sudden. I hope this won't be dealt with within one chapter or turn out be a big misunderstanding... ;D I think my feelings concerning a story haven't ever fluctuated so much from chapter to chapter.
| hmmm chapter 42 . 2/15
WHY ? ? ? You practically rewrite Ana and Christians story and only exchange the names for Ted and Amber. Well, I'm exaggerating, but it feels way too close to the original. Really loved parts of the story, but right now everything is just too easily solved (Phoebe's friend gets pregnant and she learns her life lesson, Amber gets together with Ted and now is pregnant and blabla repeat of the whole Ana/Christian story) Disappointing.
| hmmm chapter 36 . 2/15
I liked the story so far, and I thought it was a very interesting turn when Ted started "behaving badly", in a way it's a bit disappointing that you turned this around so fast. It could have made for a few interesting chapters and conversations. Now he lived a certain way for a few years, comes home, sees his sister at a party and immediately realises how wrong he has been etc. that's too fast and a bit boring (when I imagine what could have been.) All in all very nice :)
| Guest chapter 14 . 12/22/2014
I understand now why some people write shitty comments on your story, because they are shitty, come on get real with your story.
| joan.goldman.9 chapter 52 . 10/21/2014
Great story
| joan.goldman.9 chapter 20 . 10/20/2014
I'm always glad when they are together.
| joan.goldman.9 chapter 2 . 10/20/2014
This is GREAT
| joan.goldman.9 chapter 1 . 10/20/2014
WOW is this different.
| pattiecake13 chapter 52 . 8/21/2014
Omgee I loovvveeed this story! Awe would of liked to see phes and Jason's future story. Plz do a sequel! PLEASE! lol
| Alexandra chapter 52 . 8/18/2014
Don't ever stop writing your amazing! I could not stop reading.
| luvfordelena chapter 52 . 7/23/2014
aww just perfect! great story
| vdlucas chapter 31 . 6/27/2014
I'm a grandma at 42. I got married 2 days out of high school and had my son 10 months later, my first daughter 20 months later and finally my last daughter 18 months after that.
| vdlucas chapter 24 . 6/27/2014
Ted sounds like my son. When he went to prom, he paid for the girls dress, hair, makeup, flowers, tickets and limo. He paid for everything.


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Congrats to our client, the Town of Queen Creek, as its first fire department has officially taken charge of fire safety and emergency services for the Town's more than 23,000 residents. In the past few weeks, the Town has named its first fire chief, Van Summers, and swore-in 28 of its own firefighters. The Town is also acquiring its own water services and plans to open nearly $1 million square feet of retail this Spring.
Client Spotlight Client Spotlight – Town of Queen Creek
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michelle phan
VidCon's Creator track wants to foster the next generation of YouTube stars
New programming fills the void between what Community means at VidCon and what Industry feels like.
Everything we know about Endemol's new slate
All Pitbull, all the time.
Get up close and personal with Hannah Hart, Grace Helbig, and Dude Perfect
The trio joins previous creators as part of a big promotional push.
The 18 YouTube stars who scored the biggest book deals
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text: Wired.co.uk Podcast Special: Major trend forecast for 2014 Podcast 19 December 13 by Nate Lanxon Your browser does not support an audio player. Please upgrade or if you are restricted, install the Chrome Frame plugin for Internet Explorer. Add to iTunes Play in popup window Subscribe via RSS Download Wired On this special episode of the Wired.co.uk Podcast, Nate Lanxon is joined by four editors of WIRED magazine to discuss their predictions for what will be some of 2014's most important trends to watch, from real-time health monitoring to 4D printing.You can read more about the Wired World in 2014, from which some of these trends were taken for discussion, in WIRED's special issue, on sale now in print on newsstands, and from digital retailers such as iTunes for iPad and iPhone, and Zinio.Free audiobook from Audible.co.ukDon't forget to claim your free audiobook download from Audible.co.uk/wired. Sign up for a free trial to get your choice from over 80,000 titles, supported on the same device you listen to the Wired.co.uk Podcast. To listen on any device, either hit the play button above, or download using the link under Subscribe & Play.NEVER MISS AN EPISODE | SUBSCRIBE FOR FREE In iTunes for your computer, iPhone, iPod and iPad RSS feed for other podcast catchers and Google Reader etcFollow us! Wired: @WiredUK Nate: @NateLanxon Liv: @Olivia_Solon Liat: @LiatClark Music by: Filip Hnizdo Show produced and edited by: Nate Lanxon Hosted by Nate Lanxon Follow @NateLanxon Olivia Solon Follow @Olivia_Solon Liat Clark Follow @liatclark Comments Recent podcasts 238. Cephalopod consciousness, data deals: Podcast 238 09 Oct 2015 237. Uber hooha, Peeple people: Podcast 237 01 Oct 2015 236. Linguistic death, telepathic games: Podcast 236 25 Sep 2015 235. Apple Watch travel, sex robots: Podcast 235 18 Sep 2015 234. Ancient ancestors, Apple analysis: Podcast 234 11 Sep 2015 233. Melt-proof ice cream, fishing drones: Podcast 233 04 Sep 2015 2015. Flu virus, IFA 2015: Podcast 232 28 Aug 2015 231. Ashley Madison, CCTV: Podcast 231 20 Aug 2015 Latest on wired.co.uk


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HootersOctober 14, 2013Wings • Grapevine, United States
Gotta love their new sauce flavors! Just go for the 50 wings!
Gotta love their new sauce flavors! Just go for the 50 wings!
The specialty drinks are great, especially if you like to try new cocktails!
Super tastey and moist - great cupcakes! I want to try them all!
No nees to get there more than 40minutes early unless you like to wait or need to check a bag...takes 3minutes to get through security, with a line!
Not bad living...cheap and the leasing agents are great!
Try out the Watermelon Moscow Mule, so good!
The Benedict is the best on any of their brunch menus
Order food, don't eat the food it sucks!
The Cheese Frenchys are so delicious something you need to try once!
Be sure to come early computer systems are updated regularly.
Great food, you get to select and cook your own steak! Really can't go wrong, but the Bacon wrapped fillet is my favorite!
Always bring lots of dirty laundry home or Barb gets a little upset!
Ask for Chrissy, simply the best sales associate! I will be going back just because of her great customer service!
Don't forget your student ID when going to the testing center!
Don't come if have a lot of time on your hands your whole day will be gone!
If you park here often you might as well buy a semester parking pass it's worth the money!
Great place to study when its closed, nice an quiet! Way better than the library!
Try something new like jasmine tea over steamed soy with a bit of honey!!
Take HRI 383 (qwine class) P/F if you don't have to take it for a grade...you'll enjoy it more!


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My Nonprofit Reviews
Feminist Abortion Provider
Review for Feminist Abortion Network Inc, Yakima, WA, USA
The Feminist Abortion Network, or FAN, is a collective of the Fourteen remaining non-profit feminist based abortion care providers in the US. The work of these providers in their communities in providing patient centered care is the historical roots of feminist health care. The scope of care delivery for each clinic is based in specific community needs and culminates in a national impact on quality abortion care.
Due to the lack of a national presence for these independent feminist clinics, FAN was formed to represent the unique strengths, tenacity and diversity of these providers in the larger ecosystem of abortion care providers. Many of the original feminist clinics that opened in the early seventies to address the lack of abortion care post Roe v. Wade have closed over the years. FAN is committed to keeping our remaining member clinics open to serve the true needs of the vulnerable and historically marginalized communities, still not adequately served in our country. And to represent our consituents on a national level
Review for Missoula Urban Demonstration Project, Missoula, MT, USA
My daughter was a volunteer and staff member of MUD, during her studies at UM in environmental studies. I believe this experience helped form her interest in sustainable agriculture. I enjoyed becoming more familiar with MUD's work and their role in our community. They have been around for a long time and were one of the pioneers in community gardening and information and resource sharing to help others engage in their mission.


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Washington Week
Episode #4227
This week, a special "Washington Week." We look ahead at the issues and people to watch in 2003. Joining us will be: David Broder of the Washington Post on politics; Jeff Birnbaum of Fortune magazine on the economy and tax cuts; Ceci Connolly of the Washington Post on healthcare and prescription drugs; Tom Gjelton of National Public Radio on our preparations for war; and Pete Williams of NBC News on the Supreme Court. Moderator: Gwen Ifill [26 minutes]
This episode has not aired in the past few months on Iowa Public Television.
Series Description: WASHINGTON WEEK, PBS' longest-running public affairs series, features Washington's top journalists analyzing the week's top news stories and their effect on the lives of all Americans. Gwen Ifill hosts.
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There are no broadcasts currently planned. Please check back for future broadcast dates.


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Policy Briefs
- ACP President-elect outlines access problems for legislators
- College calls for an end to mandatory hospitalist policies
- ACP expresses concern about final rule on emergency medical care
- College urges Medicare to pay physicians' costs of administering drugs
- College asks for oversight on Rx data sales, deceptive practices of some DME suppliers
ACP President-elect outlines access problems for legislators
At a recent meeting in Washington, ACP President-elect Charles K. Francis, FACP, said that a problem hurting the health care of minorities—a lack of access to primary care—is showing signs of affecting all Americans.
At the 2003 Congressional Black Caucus (CBC) Annual Legislative Conference on Sept. 25 and 26, Dr. Francis described how the falling number of primary care physicians is hurting American health care. He explained that these trends are being exacerbated by several factors, including the reduced number of medical students matching to primary care careers. In addition, the number of Americans without access is starting to climb again after dropping slightly over the last several years.
To highlight potential solutions, Dr. Francis detailed ACP's seven-year plan, which aims to make health insurance available to all Americans by the end of the decade by expanding choices, competition and financial incentives for small employers, insurers and individuals. More on ACP's seven-year plan is online.
Dr. Francis also described the College's position paper on eliminating racial disparities in health care that, in part, calls for a diverse health care workforce to address the needs of minorities. ACP's paper on racial disparities is online.
College calls for an end to mandatory hospitalist policies
ACP has asked a national insurance group to oppose the practice of some health plans to require inpatient care to be overseen by a hospitalist.
In an Oct. 3 letter to the National Association of Insurance Commissioners, the College said that such a requirement can hurt quality and continuity of care, as a patient's longtime provider is most familiar with a patient's medical history and needs.
ACP said that patients must have the right to select the physician they believe is best suited to oversee their care. The College also said that all physicians charged with the responsibility of overseeing and managing inpatient care should be paid on an equal basis, regardless of whether patients elect to use their own physician or a hospitalist.
The letter is online.
ACP expresses concern about final rule on emergency medical care
While recent revisions to the Emergency Medical Treatment and Labor Act (EMTALA) clear up some confusion about the rules regulating emergency care, the College is concerned that relaxed requirements for on-call specialists may reduce the number of physicians available to see patients.
In an Oct. 1 letter to the Centers for Medicare and Medicaid Services (CMS), ACP said that the final EMTALA rule, which was published on Sept. 9, addresses the roles and responsibilities of hospitals and on-call physicians involved in treating emergency cases.
The letter, however, expressed concern that the final rule's relaxation of requirements for specialist physicians may threaten timely access to emergency care by depleting the ranks of specialists available to treat emergency patients. That situation, the letter said, could be most serious in rural areas that already suffer from a shortage of specialists, forcing internists to handle emergencies for which they have not been trained.
The letter is online.
College urges Medicare to pay physicians' costs of administering drugs
ACP is calling on the government to make sure that physician reimbursement for Medicare drugs doesn't suffer under a new proposal to recalculate how the federal program pays for drugs administered by physicians.
In a Sept. 30 letter to the Centers for Medicare and Medicaid Services, the College urged the government to address several proposals to revamp Medicare drug reimbursements. Medicare currently pays some physicians more than their purchase costs for drugs. The College pointed out that physicians use this difference to pay for the costs of storing, preparing and administering those drugs.
The College urged Medicare to make sure that revised drug payments cover physicians' costs of purchasing drugs. It also said that any reduction in payments for the drugs themselves must be accompanied by increases in what Medicare pays physicians to administer these drugs. ACP also said that increases in payments for administering drugs should not trigger cuts in other Medicare services.
The letter is online.
College asks for oversight on Rx data sales, deceptive practices of some DME suppliers
In an Oct. 6 letter to the Office of Inspector General (OIG), ACP outlined problems with the sale of physician prescribing information and with deceptive practices in the area of durable medical equipment.
The College expressed concern about drug makers who financially entice pharmacists to sell information about physicians' prescribing habits. Drug makers can use this information to tailor how they market their drugs to physicians.
The College urged the OIG to investigate and identify abuses related to the sale of physician-specific prescribing information, and to promulgate regulations that will protect the confidentiality of this information.
The College also voiced concern about the deceptive marketing practices employed by some suppliers of Medicare durable medical equipment (DME).
To limit abuses by DME suppliers, ACP urged the OIG to require DME suppliers to include explicit Medicare guidelines for coverage and to monitor advertising to make sure it meets those requirements.
The College's letter is online.
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Fenway Guide to Lesbian, Gay, Bisexual, and Transgender Health, 2nd Edition
This new edition reflects recent clinical and social changes and continues to present the important issues facing practitioners and their LGBT patients. Read more about the Guide. Also see ACPs recent policy position paper on LGBT health disparities.
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| Other Companies In This Industry
Jobs in Sefam (Pvt.) Limited
Jobs in Cotton & Silk
Jobs in HSM Virtues Pvt Ltd
About Sapphire Textile Mills Ltd
One of the largest manufacturers and exporters of textile products in Pakistan, Sapphire technology comes from Europe, Japan and USA. Capitalizing on the region's principal crop, cotton, we source this locally, and augment our offerings by providing imported fiber from the world's best crops. We work with specialized fibers bringing in the newest innovations from major fiber and chemical producers, and our manufacturing from yarn to finished fabric is performed in our facilities in Pakistan. Synergies are formed with offshore garment manufacturing companies. Our products are marketed to the industry's biggest names in Asia, Europe, Australia, and North America.


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Startup News – sorted by country
Recent JobsHead of Technology at TawiPay - Lausanne, Switzerland
iOS and Android Opportunities at fleetster - Munich, Germany
Space Manager (m/f) at Mindspace - Berlin, Germany
NLP Engineer at AYLIEN - Dublin, Ireland
Recent Comments
- Perry Oostdam on Recruitee – probably the fastest seed funding after appearing on Product Hunt
- Ieva on The hottest European travel startups in 2015
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Tag Archives: 3TS
Bratislava based Piano Media secures €2 million
Piano Media, a Bratislava based content payment system (online subscriptions) for media publishers, announces today it has secured €2 million in a Series B growth capital round from 3TS Capital Partners' Technology in Central and Eastern Europe Fund S.C.A. SICAR. The … Continue reading
Posted in Slovakia-Startups Tagged 3TS, Bratislava, content payment, funding, Piano Media, Series B 1 Comment


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Culture & Religion
April Fri 12, 2013
My remarks today are purely my own. But they're shaped by twenty-five years as a Catholic bishop and the social and religious ministries that such work involves; ministries that serve not just Catholics, but the much larger public and common good. I also served for three years as a commissioner with the United States Commission on International Religious Freedom. That experience confirmed for me the unique role that religious faith, religious believers, and religious communities play in genuine human development. It also taught me the importance of religious liberty both abroad and in our own country. Simply put, religious freedom is a fundamental natural right and first among our civil liberties. And I believe this fact is borne out by the priority protection it specifically enjoys, along with freedom of expression, in the Constitution's First Amendment. I'd like to make four brief points. Here's my first point: Religious faith and practice are cornerstones of the American experience. It's worth recalling that James Madison, John Adams, Charles Carroll, John Jay, George Washington, Alexander Hamilton, Benjamin Franklin, Thomas Jefferson—in fact, nearly all the American Founders—saw religious faith as vital to the life of a free people. They believed that liberty and happiness grow organically out of virtue. And virtue needs grounding in religious faith. To put it another way: At the heart of the American model of public life is an essentially religious vision of man, government, and God. This model has given us a free, open, and non-sectarian society marked by an astonishing variety of cultural and religious expressions. But our system's success does not result from the procedural mechanisms our Founders put in place. Our system works precisely because of the moral assumptions that undergird it. And those moral assumptions have a religious grounding. When the Founders talked about religion, they meant something much more demanding than a vague "spirituality." The distinguished legal scholar Harold Berman showed that the Founders—though they had differing views about religious faith among themselves—understood religion positively as "both belief in God and belief in an after-life of reward for virtue, and punishment for sin." In other words, religion mattered—personally and socially. It was more than a private preference. It made people live differently and live better. And therefore people's faith was assumed to have broad implications, including the social, economic, and political kind. That leads to my second point: Freedom of religion is more than freedom of worship. The right to worship is a necessary but not a sufficient part of religious liberty. For most religious believers, and certainly for Christians, faith requires community. It begins in worship, but it also demands preaching, teaching, and service; in other words, active engagement with society. Faith is always personal but never private. And it involves more than prayer at home and Mass on Sunday—although these things are vitally important. Real faith always bears fruit in public witness and public action. Otherwise it's just empty words.
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Picked up on the Japanese blog Yaraon!, this manga, titled 90% Job Turnover!? The Truth About Animators is more than just an 8-page look at the job description of Japanese animators, but rather, a boots on the ground examination of the industry. The manga is short but it makes its point fairly bluntly: making anime is not for the faint of heart.
While this manga is not representative of ALL anime production studios, it does seem to reflect the general atmosphere. In the above gallery, you can read the manga, which I have translated from its original Japanese.
Click on the lower right of each image in the gallery to expand each image to full size.
離職率90%!?アニメーターの真実という漫画 [やらおん!]


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Radio Mato Grosso do Sul
By Giovanna Albarez
Open iTunes to buy and download apps.
This application brings you many of your favorite radio stations from Mato Grosso do Sul, including:
Radio Tres Lagoas 101.7 Fm, Radio Vale do Taquari 970 AM, Radio Vida 103.3 Fm, Radio AM Capital 930 AM, Radio Auxiliadora 105.9 FM, Radio Bela Vista 1440 AM, Radio Boa Nova 106.9 Fm, Radio Bonito 98.9, Radio Caçula 1480 AM, Radio Campo Alegre 1520 AM, Radio Capital 95.9 Fm, Radio Cidade 106.5 FM, Cidade Campaua 87.9 FM, Radio Cidade Maracaju 830 AM, Radio Cidade Navirai 87.9 FM, Radio Criativa 87.9 FM, Radio CUltura 680 AM, Radio Cultura Chapadao 97.3 FM, Radio Difusora Pantanal 1240 AM, Radio Difusora Rio Brilhante, Radio Excelsior 91.3 FM, Radio Filadelfia 106 FM, Radio Atalaia 106.3 FM, Radio FM UCDB 91.5 FM, Radio Harmonia 98.3 FM, Radio Independiente 1020 AM, Radio Kativa 87.9 FM, Radio Laguna 1580 AM, Radio Nova 106.3 FM, Radio Novo Tempo 630 AM, Radio FM Dourados 94.0 FM, AudioGrooves FM, Radio Litaurica FM, Collectors FM and more!
- Bookmark your favourites stations.
- New stations added all the time by users request.
- Background playing support.
- iOS 6 Optimization.
- Social Integration.
- Totally new and improved look and feel!
- User-friendly, simple, quick and easy-to-use UI developed by renowned designer.
- Many streamings for each station (when available).
- We are constantly working to keep stations working 24/7.
▶ Miss your favorite station? Have a question or suggestion? Please, feel free to contact us at firstname.lastname@example.com
What's New in Version 3.6
- We have fixed a minor bug that occurs when trying to leave a rating.
- Other minor bug fixes.
- 1,99 €
- Category: Music
- Updated: 02 December 2013
- Version: 3.6
- Size: 3.4 MB
- Language: English
- Developer: Giovanna Albarez
- © Giovanna Albarez
Compatibility: Requires iOS 4.3 or later. Compatible with iPhone, iPad, and iPod touch.


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News from Upstate
December 10, 2012
Kathleen Paice 315 464-4839
Kathleen Paice 315 464-4839
Upstate Golisano Children's Hospital provides free flu shots during Christmas Bureau registration
Enrique Reyes prepares to receive a free flu shot while his sons, Yeik and Juniel, both 4, look on. Upstate Golisano Children's Hospital physicians and medical students will provide free flu shots to those registering for the annual Salvation Army Christmas Bureau Monday, Dec. 10 through Friday, Dec. 14 at the Nicholas J. Pirro Convention Center, 800 S. State St., Syracuse. The effort, led by infectious disease specialists Manika Suryadevara, MD, and Joseph Domachowske, MD, is part of a program designed to study the public's understanding of influenza, influenza vaccine and vaccine safety.
Search Upstate News
Upstate in the News
- Upstate hosting international kidney cancer conference
Syracuse Post Standard
- Upstate Medical provides tax-free home to developer of concussion diagnosis system
Syracuse Post Standard
- Couple hurries to move wedding to CNY hospital for dying father: 'A miracle come true' (video)
Syracuse Post Standard
- Upstate reviving the house call to keep patients with minor problems out of its ER
Syracuse Post Standard
- SU, Upstate Medical to use new grant program for biomedical, health-care research
Central New York Business Journal
- Study finds more young people are being prescribed antipsychotic drugs
WSYR TV9 Syracuse


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… Sadie, the Amish widow, and Kade, the multi millionaire? In Plain Promise* by Beth Wiseman, Sadie rents a small cottage to Kade who is trying to figure out why he's not happy being so rich. Being Amish, Sadie has a lifestyle that is very foreign to Kade and vice-versa.
… the fun of camping in Arkansas? Lucy Binoche is about to find out in Sandra D. Bricker's Love Finds You in Snowball, Arkansas*.
… the many voices of Jim Dale, the narrator for the Harry Potter audio books?
… the historical Marshfield Manor, in North Carolina? It's just been robbed. In Julie Hyzy's Grace among Thieves*, Grace Wheaten, the curator and manager of Marshfield Manor, has discovered that several very valuable items in the manor are missing. A film crew is making a DVD of the property to showcase all of it beautiful antiquities.
… the undercover federal marshal who's investigating a mining accident? In Love Finds You in Silver City, Idaho*, by Janelle Mowery, you will get to meet Rebekah Weaver who was badly burned in a tragic accident.
… someone with a talent for finding lost items? In A Timely Vision* by Joyce and Jim Lavene, you meet Dae O'Donnell, the mayor of Duck, North Carolina.
… Cassie and her late husband's plastic flamingos? Check them out in Sandra D. Bricker's Love Finds You in Holiday, Florida*.
… the real wizards of the theater? Far from our stage magicians, these men use true magic to create illusions of sight, sound, and even emotion for their plays. In Melanie Rawn's Touchstone, readers follow a theatrical troupe from their start in cheap bars to their triumphant tour of the coveted Winterly Circuit.
… the latest murder in Excelsior, Minnesota? In the newest mystery from Monica Ferris, Threadbare* tells the story of two murdered homeless women. These women really had nothing in common except that they were homeless, and when the niece of one of the women asks Betsy to help her, another body turns up frozen in the snow. Could the murders be connected?
… the new cookbook from mystery author Joanne Fluke? The Lake Eden Cookbook is a wonderful addition to the books in the Hannah Swensen mystery series*.
Contact Us


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Best Vacation Deals For You and Your Family in 2013
If you're like my family, the holidays are over and everybody just wants to get away and relax a little. Not sure where you want to venture out to? We've got a few affordable suggestions:
If you're like my family, the holidays are over and everybody just wants to get away and relax a little. Not sure where you want to venture out to? We've got a few affordable suggestions:
Along Africa's great Zambezi River, right on the border between Zimbabwe and Zambia, there is a waterfall called Victoria Falls. And at certain times of year, when the water level is just right, you can go swimming right at the very edge—looking down 100 meters into the gorge below.
Ever see those people holding and flipping signs outside of a businesses? Yeah like those statue of liberty people in front of the tax place on Timberland...
Check out this artist performing dub-dance while playing her violin so lovely.
Check out Mr. Colion Noin's perspective on mass shootings, concealed weapons and the 2nd Amendment.
On the Friday before Christmas, Ruby Modlin was grocery shopping at Walmart with her family.
The Altoona, Iowa woman noticed that a man was following her around the store. Being a glass-half-filled type of gal Modlin figured it must be somebody who recognized her -- maybe from high school.
Al Alverson didn't get the iPad mini that he had ordered through FedEx. However, the blame for the non-delivery rested squarely on UPS.
Yep, this actually happened. (Maybe.) Going down in Montreal, the video -- in which an eagle unsuccessfully attempts to snatch up a toddler -- has racked up over 1 million YouTube hits in just one day.
This one goes out to all the people who are looking for something to make them feel like lazy sacks of goo who sit around on the couch all day and never do anything.
While 'Gangnam Style' covers are all the rage on YouTube, these two creative young women have taken Psy's hit and put their own unique spin on the song. Instead of the usual flashmob and eye-catching costumes, the two young women picked up a guitar and -- strangely enough -- a ukelele to turn the snappy dance number into a plaintive pop song that sounds like something Taylor Swift would sing. (Well, if Taylor Swift was a K-Pop star, that is.)
At the end of every year, Google compiles a list of the most searched events and people and creates a video highlighting the results. The video shows events such as protests from the Middle East, Hurricane Sandy, the 2012 Olympic Games, famous celebrity deaths, Felix Baumgartner (the guy who jumped from space), and even overly attached girlfriend and Honey Boo Boo...
Of course the Emmy's are all about the top of mind awareness for movies they think are amazing. This mash-up is all about movies that not only look great together, they also made big box-office this year.


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Sex.com made quite the offer to Patriots tight end Rob Gronkowski on Wednesday and, frankly, we're surprised such a proposal has taken this long. The site has offered to match Gronk's 2014 base salary of $3.75 million if he makes a sex tape with porn star (and well-documented "friend") Bibi Jones.
Here's the press release (SFW) from the site:
In light of Bibi Jones's return to performing in adult films, Sex.com would like to offer Rob Gronkowski a chance to perform with her in a scene once his forearm has healed.
There is no question that Rob Gronkowski has what it takes to make an excellent male performer in today's adult industry. He has proven both on and off the field that he has the body and the attitude to be a hugely popular male adult star.
Football and adult entertainment fans have long speculated a romance between Gronkowski and Jones since racy photos appeared on Twitter. Sex.com believes that their controversial connection will give them a special chemistry on screen.
Sex.com is prepared to match to Gronkowski's 2014 base salary of $3.75 million if he agrees to perform with Jones in a sex scene exclusively hosted on Sex.com. Though Bibi Jones is on an exclusive contract with Digital Playground, Sex.com has contacted the production company to make an exception for this scene.
While it's a fun idea, I wouldn't hold your breath if you're anticipating this deal to actually go down. While I'm sure it's probably a pretty intriguing one for Gronk, I'd be willing to bet that Bob Kraft and Big Bad Bill would have a few objections.
In the end, you don't want to piss off your bosses…even if you're offered to throw your hot dog down a hallway for a few million dollars.


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108 BioWare 6,216 Commercial
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1 Pokie Magic 51 Shareware 12.31 MB
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Slot City 2 Plus Video Poker
MVP Software, Inc. 1 Shareware
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Hearts Desire 5 18.0
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1 Jolly Bear Games 60 Shareware
play unique minigames and explore a beautiful city in a big city adventure.
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Big City Adventure: New York City 1.0
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1 NCSoft 77 Commercial
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GetFunGames 339 Freeware 1.92 MB
MegaBonus slot Machine is a free gambling game for your computer.
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dSlots 1.0
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Are you ready for a fun and easy to play slot machine game that has great graphics? Well, dSlots is here and waiting for you to play! We have a...
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Valve Corporation 3 Commercial
Includes 10 additional maps in a variety of environments from sunlit days to dark and creepy evenings in the rain. Also added are 5 powerful gameplay...
Golden Dragon 5 18.0
Pokie Magic 28 Shareware 3.25 MB
Golden dragon is a simulation slot machine game with some eastern symbols appearing on its 5 to 6 reels. You will find that there is a mystical...
Cradle of Rome 1.1
51 Iplay 16,064
Imagine that you are given a chance to build the ancient Rome! This legendary city was one of the most beautiful and powerful capitals ever existed...
Dragon Jumper 1.6
2 Astatix Software 158 Shareware 851.33 KB
Each level you play a little dragon who lives in a magic lake. The lake is dangerous, but our little fellow loves fruits and diamonds. He loves them...
Reel Deal Slot Quest - Under the Sea 1.0
Phantom EFX 16 Commercial
slot Quest is the latest line of games from the Phantom EFX idea machine. Inspired by fan favorites, slot Quest redesigns traditional concepts to...
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slot Quest is the latest line of games from the Phantom EFX idea machine. Inspired by fan favorites, slot Quest redesigns traditional concepts to...
Little Shop - City Lights 6.6
2 Gamehouse Inc. 948 Shareware
Turn your little shop into a big city success in Little Shop - city Lights, an amazing hidden object game from the creators of Little Shop of...
Operation Flashpoint Dragon Rising 1.0
2 Codemasters Software Ltd 286 Commercial
Operation Flashpoint dragon Rising is a first-person shooter. It is a sequel to the 2001 game that attempted to change the genre by making...
Stylish City Screensaver 1.0
Freesavers2k.com 5 Freeware 6.37 MB
Stylish city is a lovely screensaver that shows a nice view of a city in black and white. The scene shows a city at a huge lake or river at night....
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