text:
Hotel Hydro Majestic Blue Mountains
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Wireless internet connection in room (surcharge)
- Wireless internet connection in room (free)
- Wireless internet connection in public areas
- Multilingual staff
- Refrigerator in room
TravelPod Member ReviewsHotel Hydro Majestic Blue Mountains Katoomba
A gorgeous place to have a long lazy afternoon tea traditional oriental vegetarian and even glutton free
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Although the entrance and lounge were beautifully furnished in art deco style, the rooms were VERY small and the en suite tiny. If you do book a room make sure you ask for a mountain view otherwise you will get a view of the highway and the trains. Fantastic view of mountains from lounge but no access to the balcony outside. Staff very pleasant and helpful but very disappointed with accommodation and external surroundings.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Historical Traveler Reviews Hotel Hydro Majestic Blue Mountains Katoomba
Bizarre hotel with an amzing view
Plus - amazing valley views. Negative - everything else! This is a bizarre hotel straight out of a Hitchcock film. Taken over by Accord hotels but still looks very unloved - incredible potential but sadly misses by a long way. Rooms are absolutely tiny but servicable. Bar - bare with no atmosphere (could be fantastic). Restaurant - set up for coachloads of tourists on a day trip to Blue Mountains. Service - the staff mainly grunt at you and look as old and bizzare as the hotel. Gym - one bike and a jogger - full of leaves and looked like it hadn't been cleaned/used in years. Location - there is nothing close by and you really need your own transport. This place is crying out for to some TLC and an owner with some vision. It is much cheaper than other hotels but save your money and stay at Lillianfells etc.
Step back in time with the Art Deco charm of the Hydro Majestic
We stayed at the Hydro Majestic for a couple of nights at the end of November and immediately fell in love with the shabby-chic charm of the place. Lots of lovely art deco furnishings, long elegant hallways with comfy sofas - it was like stepping back in time. Our room (overlooking the Megalong Valley) was small, as was the bathroom, but both were clean and well equipped. The breakfast was superb - possibly the best I've had anywhere - an extensive hot buffet plus all the fruit, cereal, breads and preserves you could want, as well as do-it-yourself waffles (great fun) and Swiss Bircher Muesli, which we really hadn't expected to find in Australia. Certainly one of the highspots of our holiday.
Spectacular Views, Like No Other
Arriving at the hotel in the early afternoon, we had a very warm welcome from a smiling receptionist. After checking in, she then advised that the hotel served'High Tea'which was beautifully arranged with a selection of scones, french pastries,gourmet sandwiches along with devonshire tea. That surely did cure our hunger pains from our long drive.In the 'Pump lounge' and throughout the hotel we were surrounded with ambience of the Hydro Majestic and its staff enjoying every part of the experience. While the kids were swimming in the pool for the rest of the afternoon, we joined the guided history tour.For a moment we had stepped back in time whilst listening to facinating stories and ghostly happenings the tour ended at the Hydro Lounge.We then enjoyed our first cocktail on the escarpment balcony and watched the sun set, overlooking the spectacular views 'like no other'of the Megalong Valley.Its fantastic to see the hotel has kept its old charm and elegance.
Old World Charm
We stayed at the Hydro Majestic for my birthday. I was a little suprised by the smallish rooms but as the site is heritage listed the rooms can not be modified. I would recommend the history tour which takes you around the complex. If you decide to drive to Katoomba for dinner don't expect a car park when you get back - parking is limited and it is difficult to carry luggage to the foyer- best to check in first and find the closest entrance before dragging luggage throughout the building. A moutainview room would be more peaceful as the garden rooms face the highway and our room was situated near a stairwell making it rather noisy.
Views plus
Entering the foyer my fist impression was one of stepping back in time. Old world decadence oozes through the pores of this wonderful establishment. From check in to check out the staff conducted themselves in a friendly, elegant and knowledgeable manner. Whilst being escorted to our room our host delighted us with a commentry explaining the history and hauntings of the 100 year old building.
Our room was small, uncluttered and an absolute delight, the view spectacular and the decor in total balance with the overall vibe of the building.
Late at night when all is quiet stroll through the corridors and open spaces of this beutifully erie hotel, the floor boards creak back into place behind you, there's a draught and goosebumps swell. Are you being followed by an unseen spectre?
Would not stay here again
First, the hotel is overpriced. We paid only AUD $135 a night, and this was too much. I found this "hot deals" rate on their website, and despite reading previous bad reviews for the hotel, I decided to book anyway because it was one of only a few hotels in the Blue Mountains that I could book online. If I could do it again, I would wait and book one of the motels in Katoomba, which from the outside looked like they would be nicer than the Hydro Majestic, and would be much cheaper.
Second, the hotel is on a major highway, so expect major road noise. Since we booked the basic room, we were facing the highway, with loud trucks going by late into the night. The windows are old and have no insulation. Luckily, I packed a pair of ear-plugs, and I put them to good use.
Third, the interior of our room was old and dated, just like the hotel. The furnishings were ragged and worn, although they appeared clean. The furniture and bedspread were ugly and looked like they were purchased at a thrift store. The toilet in the bathroom ran. I don't agree with others about the room size. It was not all that small, but rather average.
Last, the worst part of the experience was the bed. Our "king" bed was actually two twins pushed together. One half of the bed was lumpy and extremely uncomfortable.
I stayed in Australia for three weeks at nine different hotels. The Hydro Majestic was the worst of them, and it is one of only two places that I wouldn't stay at again.
An absolute shocker!
We thought this hotel must be beautiful given its 4.5 star rating and the fact that it had been overhauled 4 years ago.
How wrong we were!
We had to park on the highway as there was not enough guest parking, there were no porters, our room was on the hallway, not soundproof and people were running past - it was so noisy. The decor was old and drab, the furniture looked like it was from a 2nd hand shop, the linen was so outdated, it was dirty - the surfaces had dust all over them, and marks that could have ben cleaned off but were not. The windows were filthy, the toilet ran....
The room was tiney - my bathroom is bigger! We first rang to get a better room but thought the place was not worth the $260 we were playing. We checked out within 10 mins of arriving at no charge.
Found a BEAUTIFUL bed and breakfast for $295 - Echos. Absolutely stunning. Perfect, spotless, beautiful food, excellent staff.
We'd driven past on many occasions and thought from its size and name that it must be the place to stay in the Blue Mountains. How wrong we were! We booked in for two nights after our wedding and although it had a lot to live up to after our wedding accomodation it was very disappointing. We had the romantic package which included basic room, champagne, strawberries, robes, massages.. When we got there the staff must get people upgrading all the time as the basic room was way too small and noisy right on the highway. We upgraded to their cloister room which was also tiny and worn bedspreads. There was no sign of any champagne, strawberries or robes so we called and they sent a bottle and some sad looking strawberries. No robes. We booked in for our massages which were in a little room with an asian lady in a deserted part of the hotel. Our dinner was in the dining room and the food was not very good. I asked for medium steak which came bloodied. Someone at another table took one look at their quail and said I'm not eating that. We found the menu used silly words like 'jus' and 'emulation'.
We declined to stay another night and went home instead a day early. I think the hotel is ok for the older age group its very old fashioned and creepy with old music and decor.
Disappointed in the historic landmark hotel HydroMajestic
We arrived at the HydroMajestic Hotel on a foggy, rainy morning. The great view from the dining room was thus obscured. The rooms were small, drab, with broken down mattresses and old worn bedspreads and drapes. They were also subject to noise from a very busy highway...many trucks. We were so disappointed that the hotel manager let us out of our reservation without charge, and we took an $8. AUD taxi to Katoomba, where we checked into another historic hotel, The Carrington, which we loved. It has far more charm, updated decor, lovely rooms, and at less cost. It includes a wonderful buffet breakfast in a beautiful dining room with chandeliers, and big windows. In Katoomba,we ate dinner at a small, reasonable, but gourmet restaurant called Journey. The chef is a pro, and his wife is the waitress. Both the hotel and the restaurant are locally owned by talented people who really care! In contrast, the Majestic, has been bought and sold by one hotel chain after another...now a "Flag Hotel". Sad to see the neglect! Overpriced, it continues to be touted by travel agents, who send in the bus tours.
Good overall but small rooms
Excellent service in this rather old fashioned hotel. Rooms are smnall and we had to upgrade twice to get one big enough to contain our suitcases!
TripAdvisor Reviews Hotel Hydro Majestic Blue Mountains Katoomba
Travel Blogs from Katoomba
Sydney And The Blue Mountains
So we had a day and a half back in Sydney (getting feet looked at after I lost my nail hiking ouch) some needed shopping and hair cuts etc And our Friday night was so special I was so excited to be seeing my most favorite gorgeous Gold Coast Friend Jen Jen Jackson and her new man Blinky. Jen Jen has flown down from the Gold Coast to meet us all for …
Blue Mountains
On Monday morning we left Hunter Valley to head towards Sydney on the Pacific Highway and up to the Blue Mountains. On arrival we checked into our hotel in Medlow Bath and then drove to Katoomba, which seems to be the home of all the old hippies! However, its history goes back 22,000 years and was populated by the Gundungurra, Darug and Wiradjuri …
And that's when I fell off the train!
... offered more fantastic views of the mountains, and three sisters at Echo point. We jumped back on the bus after that to make the most of the bus tour before sunset. The sun sets here at 5pm. The village was very quaint and peaceful. A lovely little town. We grabbed a quick bite to eat and ran to the warmth of the train. Even with gloves on, it was freezing. (Just as well I brought an extra pair for NZ!) Back to the hotel to pack. Tomorrow we head to ...
FRIDAY Lawson 8-12 Springwood 9-16
Partly cloudy. Light winds. 7am 4.3 degrees feels like 1.8 Nice looking morning, the rain is gone. It has been a beautiful day ... I went to RMS Katoomba for the permit to tow an unregistered trailer and then we successfully towed the crook diesel splitter to Seven Hills. A nice man came down to confirm that they would assess ASAP and to mention it wasn't legal to tow it ? We reassured him that we had ...
WEDNESDAY Lawson 8-15 Springwood 9-18
Clear. Winds westerly 20 to 30 km/h becoming light in the evening. 6.30PM 6.7 degrees feels like 0.4 It is indeed a cold evening. I am late with this today, this morning was different. Simon came in at 5.30am with news that the trains were disrupted, we said drive Snowflake to work, then I heard on the traffic report that the M4 was disrupted with an accident. Sooooo I then drove Simon to Penrith ...


text:
The Monuments Men and Their Legacy
Wednesday, 10.08.14
Begins at 11:30 AM and goes to 12:30 PM
The Brown Bag Lunch & Lecture in Museum Studies Presents
The Monuments Men and Their Legacy
Mr. Louis Rorimer, son of James J. Rorimer, will speak about art recovery during the war. Rorimer served as one of the U.S. Army's Fine Arts Monuments and Archives group (The Monuments Men) during World War II and later became Director of the Metropolitan Museum of Art in NY through 1966,
This event is free and open to the public.
LOCATION: Barrette Business and Community Center
For more information, contact Katey Brown, Director of Museum Studies, firstname.lastname@example.com

subset: commoncrawl


text:
IMPORTANT: Please click "End Session" to clear your personal information. (Credit Card info is always hidden from view).End Session
Cookies are not enabled in your browser.
You must have Cookies enabled for the best experience on our site and to make a purchase.
Learn how to enable Cookies in your browser or call 1-800-426-8020 for assistance.
Women's Women's Burnout Henley Shirt$50.00 $24.99
Women's Women's Favorite Sleeveless V-Neck T-Shirt$18.00 $10.80
Women's Women's Short-Sleeve Favorite V-Neck T-Shirt$20.00 $12.00
Women's Women's Favorite Long-Sleeve V-Neck T-Shirt$28.00 $16.80
Women's Women's Favorite 3/4-Sleeve Scoop-Neck T-Shirt$25.00 $15.00
Women's Women's Gate Check T-Shirt$45.00 $14.99
Women's Women's Wrinkle-Free Long-Sleeve Shirt - Print$70.00 $42.00
Women's Women's Wrinkle-Free Short-Sleeve Shirt - Solid$50.00 $30.00
Women's Women's Packable Short-Sleeve Shirt - Solid$45.00 $29.99
Women's Women's Favorite Long-Sleeve Crewneck T-Shirt$25.00 $15.00
Women's Women's Short-Sleeve Favorite Crewneck T-Shirt$20.00 $12.00
Women's Women's Graphic T-Shirt - Diamond Relief Print$28.00 $13.99
Women's Women's Wrinkle-Free Long-Sleeve Boyfriend Shirt$70.00 $42.00


text:
The Most Awaited Music Album of This Year, Prem Ratan Dhan Payo Full Album has been Released Earlier Today. As Promised The Album Brings Back The Trend of Soulful and Melodious Songs. Each and Every Song has Its Own Flavor and is a Treat to The ...Read More »
Watch Full Event : Salman Khan at The Tata Sky Active Fitness Event
Salman Khan Recently Attended An Event Called 'Tata Sky Active Fitness' Where He Talked About His Fitness How He Maintain His Ultimate Body Without Following Any Special Diet Plan. He was Accompanied by His Dear Friend Sunil Shetty Who was All Around with Praising Words for ...Read More »
Watch Sonam Kapoor's Full Speech on PRDP Trailer Launch
Here is The Video – Watch Sonam Kapoor's Full Speech at The Grand Trailer Launching Event of Prem Ratan Dhan Payo. Must Watch The Video, If You Want to Know More About PRDP and Sonam's Role in it. She Talked About Many Things and Answered Many Questions ...Read More »
Watch Prem Ratan Dhan Payo Official Trailer
The Most Iconic and Loving Character of Bollywood, Prem Salman Khan is Back in Rajshree Film. Here is The Official Trailer of Royal Film, Prem Ratan Dhan Payo. The Trailer can Easily be Termed As One of The Best Trailers of Bollywood Ever. The Khan Steals ...Read More »
Official Posters of Prem Ratan Dhan Payo
Prem is Back. The Everyone's Eternal Favorite Prem Salman Khan is Back. Here are The Official Posters of Salman Khan's Most Awaited, Most Anticipated Film Prem Ratan Dhan Payo. The Posters Reveal The Prem at His Romantic Best with Sonam Kapoor. The Teaser Poster is Also ...Read More »
Watch Full Event : Salman Khan at Bigg Boss 9 Press Conference
The Best Host of India Salman Khan Last Evening Attended A Grand Event, The Press Conference of The New Season of Bigg Boss. The Khan for The Sixth Time in A Row will be Seen Hosting The Show. Yesterday, He Announced The New Season Bigg Boss ...Read More »
PRDP Teaser Poster to be Out on 29th September
Finally Its Arriving. Earlier Reported, The Trailer of Much Awaited Film Prem Ratan Dhan Payo will be Out on This Thursday and Here Comes Another Big News. According to Taran Adarsh, The Teaser Poster of The Film will be Out Tomorrow Means on Tuesday, 29th September. ...Read More »
Salman Khan Starts 2 Months Intense Training for Sultan
The Bollywood King Salman Khan is Getting Ready for His Next Eid [2016] Release Sultan as He Begins Training for The Film. He Himself Revealed Earlier That, He will be Seen As A Very Strong Wrestler and would be Training Real Hard for Th Role and It ...Read More »
'Prem Ke Saath Trailer Dekho'
All Salman Khan Fans Get Ready for The Biggest Dhamaka of This Year. Recently I Stated That The Trailer of The Most Awaited Film of This Year Prem Ratan Dhan Payo will be Unveiled on October 1. Now What I Heard, There will be A Grand ...Read More »
Kabir Khan Yet to Take Decision on Working with Salman Khan Again
After The Super Duper Success of Bajrangi Bhaijaan, Kabir Khan Declared That He will Team Up with The Bollywood King Salman Khan for The Third Time. There has Never been Any Formal Announcement. Reportedly, He has Now Two Projects in Which He would Work. One with Salman ...Read More »


text:
"Rather than focusing only on individual varieties of dinosaurs, we are attempting to reveal what life was like in Mexico 72 million years ago, and understand how the unique ecosystem of Mexico relates to ecosystems to the north at the time," said Loewen.
Few North American dinosaurs from this time period are known outside of the Drumheller region of Alberta. Eberth explained that researchers now have two points of comparison to examine not only different dinosaurs, but also different environments and ecologies.
As might be suspected, paleontologists are excited about the future paleontological potential of this area. "There are definitely more dinosaurs to be discovered in the region," Lund said.
"Dinosaurs from this particular period are important because this is a time that is relatively poorly understood," said Don Brinkman, a researcher at the Royal Tyrrell Museum. He is studying non-dinosaur vertebrates found at the site, including turtles, fish, and lizards. "The locality in Mexico goes a long way to filling in a gap in our knowledge of the record of changes in dinosaur assemblages throughout the Late Cretaceous."
Fact Sheet: Major Points of the Paper - Coahuilaceratops magnacuerna
|Contact: Patti Carpenter
University of Utah


text:
Edit hours
Arby's is a leading global quick-service restaurant company operating and franchising over 3,400 restaurants worldwide. Arby's was the first nationally franchised, coast-to-coast sandwich chain and has been serving fresh, craveable meals since it opened its doors in 1964...
The Market Fresh sandwiches are big enough for two.
Trust is great!
This is a nice place 2 go 2 and eat, they have a good roast beef sandwich here.
Big beef n cheddar
Add roast beef dipping to any sandwich. Awesome
Jamocha oreo shake is the best. Extra oreo can be ordered. Definitely worth it!
The promotional jamaoca oreo cookie shake leaves much to be desired. Very little oreo...and its just the cookie crumbs, no wonderful oreo filling. Sad. Avoid it.
A little expensive, but highest quality fast food. Never any lines.


text:
Coming up in the next {{countdown}} {{countdownlbl}}
Coming up next:
Skip to this video now
Now Playing:
Play Video
This transcript has been automatically generated and may not be 100% accurate.
Okla. Governor on Tornado: 'We're Resilient, Strong'
Mary Fallin talks to George Stephanopoulos about the devastation from a 2-mile wide tornado.
Oklahoma Tornado Leaves Behind Mangled Heaps
The 2-mile-wide tornado reduced neighborhood blocks to smoking piles.
Now Playing: Okla. Governor on Tornado: 'We're Resilient, Strong'
Now Playing: Oklahoma Tornado Leaves Behind Mangled Heaps
Now Playing: Oklahoma Tornado Destroys City for 2nd Time
Now Playing: Bill O'Reilly on New Book 'Killing Reagan'
Now Playing: Donald Trump Says Wife Would be 'Unbelievable' as First Lady
Now Playing: Donald Trump: Don't Blame Gun Laws for Oregon School Shooting
Now Playing: Couple Gets Married Amid Major South Carolina Storm
Now Playing: University of Louisville Faces Investigation Into Escort Allegations
Now Playing: Oregon Campus Hero Discusses the Tragic Shooting
Now Playing: South Carolina Faces Aftermath of Historic Flooding
Now Playing: President Obama Reacts to Jeb Bush 'Stuff Happens' Remark
Now Playing: Man Arrested in Connection to Murder of Texas Dentist
Now Playing: Gay Couple Joined Kim Davis for Meeting With Pope Francis
Now Playing: Oregon Campus Shooter Background Emerges
Now Playing: Inside Look at the Deadly Shooting at Umpqua Community College
Now Playing: Nine Victims in Umpqua Community College Shooting Identified
Now Playing: Mattel Gives Classic View-Master Toy Modern VR Makeover
Now Playing: Rare Mammoth Hybrid Unearthed by Michigan Farmer
Now Playing: 13 Guns Recovered at Oregon College, Shooter's Home
Now Playing: Oregon College Gunman Described as 'Shy,' 'Respectful'
Now Playing: Woman Reunited With Wedding Ring After Calling 'Ring Finder'
Now Playing: Women Kicked Off Napa Valley Wine Train File $11 Million Lawsuit
Now Playing: {{itm.title}}


text:
Nicole Lana Patton Model
Anadil ChowdhuryPhotographer Male Honolulu, Hawaii, US My MM URL: http://www.modelmayhem.com/anadil
Mayhem # 1981505
About MeI have been shooting since 2009. Have a lot of experience in photo shoot, weddings, Macro, product photography, Co splay, landscape photography. TFP shoots are welcome.
Nicole Lana Patton Model
Shantel Racoma Model
Franziska Faulstich Model
Drea Jane Model
Mikella Wong Model
Cherry Van Greer Model
Loading Content


text:
6633 Eighteen Mile Road
Sterling Heights, MI 48314
(586) 884-9320
Fax: (586) 884-9331
Hours: M-F, 8 a.m. - 5 p.m.
09/15/15 - Intro to Coding
Read More
09/09/15 - BBCetc Proposal Prep for DoD
Read More
09/01/15 - Capital Raise Meetup
Read More
07/17/15 - Macomb Daily: "Sterling Heights firm earns incubator grant"
Read More
05/24/15 - Crain's Detroit: "International business grows at Velocity Center"
Read More
02/03/15 - Capital Raise Meetups 2015
Read More
Macomb-OU INCubator
The Macomb-Oakland University INCubator supports economic development in Southeast Michigan by accelerating high-tech businesses, cultivating academic innovation and encouraging research and development.
URBN Technology
Mac-OU INC welcomes one of its newest client companies, URBN Technology!
URBN is an engineering solutions company that focuses on fixing problems for businesses, specifically with solutions in gesture and facial recognition, data gathering, penetration testing, and mobile applications, among others. Current client sectors include entertainment, medical, legal, and law enforcement.


text:
***3 Bedroom,3 Bathroom Villa With Private Pool,Great Views in North Cyprus Kyrenia /Catalkoy***
3 Bedroom, 3 Bathroom Villa With Private Pool, Sea And Mountain Views in Catalkoy Full individual title deeds. 3 double bedrooms all with balconies, master bedroom has en-suite and walk in wardrobe. Marble flooring throughout the house. Spacious o
- House
- 3 Beds


text:
Join FREE | Login
+ Celebrations
+ How-To
+ Deals
©2014 General Mills, Inc. All Rights Reserved. This information will only be used to send an email to your friend(s) and will not be saved. Please read our Privacy Policy.
Mini Italian Shepherd's Pies
Sweet and Spicy Chicken Flatbread
Chicken Soft Tacos
Spinach and Beef Lasagna
Carnitas Gorditas with Creamy Chipotle Sauce
Pear and Greens Salad with Maple Vinaigrette
Italians serve an assortment of appetizers for antipasto. You can vary this main-dish salad version by using other savory ingredients you have on hand.
© 2015 ®/TM General Mills All Rights Reserved


text:
With 1.7 million freelancers, we'll match you with the perfect talent.
The client has made the following changes to the job.
Job awarded.
Client prefers freelancers from:
You are still able to submit a proposal for this job.
The client prefers freelancers from
a different location.
I need a custom web 2.0 background for a website we are building. Looking to have a web 2.0 background with gradients, etc like these 2 sites:
[obscured] /
[obscured] / (like the top part with design images but with gradients
[obscured] /
and we want the center part that will hold the content to have some light gradient separators this way we can separate content without having traditional "blocks". The site will have a logo at top and menu that we might want to be glassy or similar ... just a suggestion. We are open to vibrant solid design.
And maybe can add some text as a sample .. sort of like a home page but we really dont need a whole design. Main thing is background. And then we'll want the graphics, we dont need html or any coding.
If you can show some websites you have done, this will help award project.
2 main colors of the site are: #24a936 and #009de3 but colors that will work with these are fine.
So I need a cool background. That is what's need...
Sign in or Register to see more


text:
Janet E Johnson
Janet is a 13-year veteran of the social media & internet marketing world. She consults & trains small businesses mainly in branding, social media optimization, content creation & SEO. Her success at helping clients get results led her to create a social media training program called 15 Minute Social, where business owners can learn social media at their own pace via simple lessons.


text:
Recent articles
Racial profiling, diversion funding bills signed into law by Gov. Brown
Among the criminal justice bills Gov. Jerry Brown signed into law over the weekend are a data collection bill intended to combat racial profiling and another that aims to reduce recidivism among people with mental illness.Brown signed Assembly Bill 953, which requires law enforcement agencies to collect and report to the state basic information about traffic and pedestrian stops as the nation continues to grapple with sensitive issues of race and policing. The bill would require state...
Diversity in Southern California's Asian immigrant community
Two decades ago, Michael Kwan's mother offered to buy him a new car to replace his 1980 yellow Toyota Celica that he had bought used for $500.But the then 24-year-old, who had worked as a busboy and server in Chinatown since emigrating from China with his family seven years earlier, told her he'd rather borrow the funds to open his own restaurant.• VIDEO: Jing Li of Alhambra talks about why she came to America from...
Why some local LGBT Catholics are excited about Pope Francis' U.S. visit
Catholic lesbian Cecilia Arvizu watched proudly as her 5-year-old daughter created a sign featuring a photo of her family — including the girl's two moms — for her grandmother to hold up at this weekend's papal Mass in Philadelphia. The girl, Malena, wrote "I am love" on the back of the sign and later gave it to her grandmother to hold before Pope Francis and other Catholic faithful on his first visit to the United States, Arvizu said.
Yom Kippur
Why some rabbis are moving away from fasting on Yom Kippur
Minutes before he was about to lead the afternoon Yom Kippur service last year, Rabbi Jon Hanish suddenly found himself in severe back pain.The rabbi at the Reform congregation of Temple Kol Tikvah in Woodland Hills, who had been fasting that day as is customary, went to lie down on the couch in his office but the pain only increased. Feeling faint and weak, he asked for a drink of water and a piece of bagel. He was soon rushed to the hospital, where doctors discovered he had...
Los Angeles, San Bernardino counties battle higher poverty rates
Local poverty rates remain stubbornly high despite lower unemployment, census figures show. More than one in five people were living in poverty in San Bernardino County last year while the poverty rate in Los Angeles County didn't lag far behind, according to data from the U.S. Census Bureau's American Community Survey.San Bernardino County's poverty rate was estimated to be 20.6 percent in 2014, up from 19.1 percent the previous year and up from 18 percent...
Deputy told firefighter husband she wanted to separate on night of murder-suicide, sheriff's officials say
The night she was fatally shot by her firefighter husband in an apparent murder-suicide, Sheriff's Deputy Cecilia Hoschet told her husband she wanted to separate from him, authorities said Tuesday.Hoschet's Los Angeles County firefighter/paramedic husband, James Taylor, allegedly shot her in the head with a...
Rosh Hashanah
Venice Beach drum circle, nature hike part of this community's Rosh Hashana traditions
Southland Jews — many clad in white to symbolize purity — will spend hours praying in synagogues Sunday night and over the following two days in honor of Rosh Hashana, the Jewish New Year.But the Los Angeles-based spiritual community of Nashuva will also be holding a massive drum circle and service on the sand at Venice Beach on Monday evening, a decade-long tradition that has grown to include a ceremonial blowing of the shofar, or...
Gang-related crime
How the U.S. is working with Central American nations to fight the MS-13 and 18th Street gangs
In El Salvador, gangs are attacking police and soldiers with brazen new tactics. Since January, 43 members of the police force have been assassinated.In the U.S., transnational gangs have become increasingly evident in drug trafficking, extortion and, in some parts of the country, pimping and prostitution, the FBI says. It is against that backdrop that about 70 law enforcement officials and prosecutors from seven countries gathered Wednesday at the Kenneth Hahn Hall of...
Clues sought in apparent murder-suicide involving La Cañada Flintridge deputy, firefighter husband
Homicide detectives have interviewed a 6-year-old boy who was at his family's La Cañada Flintridge home when his off-duty sheriff's deputy mother was apparently fatally shot by her firefighter husband in a murder-suicide Sunday night, authorities said Tuesday.Los Angeles County sheriff's homicide detectives were still searching for a motive Tuesday in the murder of 32-year-old Cecilia Maria Hoschet, a two-year employee of the sheriff's department,...
International agreements
Southern California lawmakers polarized after Iran nuclear deal survives
Southland lawmakers' responses ranged from cautious optimism to outrage after President Barack Obama on Wednesday secured the last Senate vote needed to ensure the survival of the proposed Iran nuclear deal in Congress.Senate Democrats clinched the 34th commitment from Maryland Democrat Barbara Mikulski, enabling the deal's supporters to uphold Obama's veto, if needed, of a disapproval resolution Republicans are trying to pass this month. The controversial deal,...


text:
Product Details
Universal Mirror Mounting Kit by CIPA®. The Auxiliary Mirror Mounting Kit is a bracket for mounting and extending convex mirrors from other brackets, bars, or tubes.
- Extends your vision through your CIPA HotSpots
- Universal design
- Easy bolt-on installation
- Can be an extension or replacement solution
- Rust and corrosion resistant
It is intended for round convex HotSpots that are 5 inch, 6 inch, 7.5 inch, and 8.5 inches in diameter. The bracket is universal in design, and can really be used for many projects that the avid Do It Yourselfer may be working on. It features a 4.5 inch stainless steel extension tube and comes with a rust resistant bracket, and rust resistant hardware.3.38Brand: CIPA Part Number: 70324 UPC: 047662703245
CIPA® is based in Port Huron, Michigan, a small suburb near Detroit, the heart and soul of the automotive industry. Most of CIPA's business is supplying OEMs with the best mirrors and accessories possible. The ability to swim (and survive) in the supplier shark pool means they have mastered the manufacturing and delivery of first-rate products. In turn that means that the OEM-replacement and unique aftermarket parts they sell are all of OEM quality.
- Vehicle FitmentThis part is universal
Year Make Model Fitment Notes This part is universal
Product Reviews (0)
Product Reviews (0)
More Accessories
You will never pay more with CARiD! Not only will we match prices from any competitor's website or other reputable source, we will continue to honor that promise for up to one year after your purchase.
We'll match the price at time of purchase, or refund you the difference if done after the purchase. Either way, we are totally committed to providing you the best online shopping experience.
We're car and truck enthusiasts, just like you! And it's enthusiasts we hire in our Sales and Service Centers. Many of our staff are ASE certified and have spent years in the retail auto business.
We conduct our own in-house training, and we even bring vendors to us for hands-on product training demonstrations. You're getting true expertise when you phone or email us!
With hundreds of vendors, and tens of thousands of components for sale, we put tremendous effort into coordinating our data with our vendors' data in order to guarantee that you get the correct part.
Our huge database is regularly cross-checked to keep it current and optimized. At times, our thoroughness makes our data even more accurate than our suppliers! This rigorous process means that you can always order with confidence.


text: Forbidden Broadway Religion and Belief Christianity The Book of Mormon (musical) Mormonism Marcus Stevens (left) and Scott Richard Foster (right) parody "The Book of Mormon" in the New York production of "Forbidden Broadway." Photo by Carol Rosegg. This photo is featured in these articles: latimes.com Forbidden Broadway takes a bite out of Big Apple musicals


text:
Portable WiFi Network Monitor1.0
editor's review
Portable WiFi Network Monitor is a lightweight application that can conduct an extensive scan on a Wi-Fi network in order to detect potential intruders. It processes a given IP range and retrieves a list of all active connections, which you can then save for later use.
Portability perks
It is the portable version of WiFi Network Monitor, designed as an exact replica of the latter, the only difference being in the deployment process. As opposed to the setup-based approach, the to-go edition does not require installation and can be carried on a removable drive and put to use on any computer.
Scan the network automatically or set an IP range
Portable WiFi Network Monitor is a network scanner, in essence, and this is made obvious gradually, as you experiment with it. Its inner detection engine automatically searches for Wi-Fi networks and calculates the corresponding IP range in order to ease your efforts.
However, it is possible to change the IP interval via the Manual mode. Once this parameter is set, you can initiate the scan process which can take a fair amount of while, depending on the length of the range. Upon completion, the program displays a prompt that informs you about the number of hosts connected to your wireless network.
A more detailed report is provided inside the main window, where you can view the host names and MAC addresses of the devices that are active inside the Wi-Fi network. However, there's no possibility to reject connections or ban IPs, which is yet another proof of the application being a scanner rather than a monitor.
Bottom line
In conclusion, Portable WiFi Network Monitor provides a simple way of keeping tabs on the IPs that are connected to your network. There's no actual monitoring option, despite what its name implies.
Also available: WiFi Network Monitor
top FREE alternatives
top PAID alternatives


text:
Connected BooksSee More Connected Books
If you like this, Harlequin recommends
- Adopted: Outback Baby
- by
- Jul 2008
- Expecting Miracle Twins
- by
- Sep 2009
- Blind Date with the Boss
- by
- Nov 2008
- Her Cattleman Boss
- by
- Mar 2009
How to be the Perfect Bridesmaid:
a) Smile and pretend to love your horrible dress.
b) Be patient as your best friend turns into Bridezilla.
c) Do not fall for the groom!
Thrilled to be Bella's bridesmaid, Zoe throws herself into her duties. But meeting the groom himself, stop-and-stare-sexy Kent Rigby, ruins everything....
What happens when you find the man of your dreams and he belongs to someone else?


text:
Gifts by Price
Gifts by Recipient
Gifts by Occasion
Featured Gifts
Daily Sales Up to 70% OFF Limited-time deals start every day at 12 pm ET.
Free Shipping
Product Information:
Product Details
Special Offer:
12 Issues of Money Magazine
Included with purchase ($20 value).
Weights & Dimensions
|Number of Compartments: 1
|Color: White
|Floor Levels: 1
|Animal Capacity: 1
|Product Warranty: Limited one year
About the ManufacturerIn 1999, Home Bazaar set out to create the world's most spectacular line of birdhouses and birdfeeders. In their workshop, they have combined their love of birds and nature along with technical and design abilities.
They are now pleased to introduce to you the Home Bazaar Line of Architectural Birdhouses, Feeders, Pedestals and Garden Accessories. Using only the finest materials available with a painstaking attention to detail, their products are manufactured to be used functionally outdoors and be enjoyed for years.
Their distinctive Bird Houses and Feeders product can be matched up with an accommodating garden pedestal. These pieces can be easily placed in the backyard or in a garden setting. The cottage design combined with the Victorian scrollwork often end up close to the home, on a covered porch, and in many cases are used in the home as a decorative accessory.
They are constantly bringing unique new designs to market that allow you and your feathered friends the finest in avian housing. In addition, they will be bringing you new, exclusive items for outdoors as well as in the home.
More About This Product
Free Shipping
Ships to:
Ships via: FedEx/UPS
Enter your shipping zip or postal code to calculate shipping estimatesGet Delivery Estimate
We want you to love it. If you don't, you may return your purchase within 30 days of delivery. All you need to do is visit our Self-Service Return Center for instructions. Return credits are issued within 24 hours once the item is received and inspected. Please note that shipping charges are non-refundable. The cost of return shipping will be deducted from your refund. 30-Day Return Policy
Overall Rating
Based on 1 review
Customer PhotosAdd your own photo
Cute Birdhouse Ami from Toledo, OH on 01/06/2015 – Verified Buyer
The bird house is super cute. The only thing was, one of the pieces fell off right away but we re glued and all was good.
Was this helpful? Yes 0 No 0


text:
I have a two and a half year old daughter, and this holiday season is really the first that she is old enough to participate in – and boy oh boy, have we had some fun!
This week, I was at Sam's Club picking up supplies for a holiday party I am throwing when I came across an aisle of activities that I knew my daughter would love – including a rice krispies treats trainset and a gingerbread man decorating set. I snapped up the latter and was on my way!
When I got home, I set up all the components on our coffee table so everything would be at her level.
While she wasn't able to handle the frosting on her own, we applied the face together!
Next up! Mr. Gingerbread Man's coat!
And ta-da! A completed holiday cookie!
And I even got a bite!
Disclosure: I am a paid endorser for Sam's Club


text:
The alienated foes of American imperialism are making their move. This is a pretty profound statement in this fairly mainstream format. The tinderbox is getting hotter by the minute. They're gonna have to pull something nasty and dramatic to shift this paradigm of growing public perception. Be prepared but don't fear. – Zen
"The task has in recent days become more daunting. Members of Congress return to Washington on Monday after mostly being besieged by their constituents to vote against action. Getting an authorising resolution through the Senate looks difficult; prospects of passage by the House look even tighter, with more than 200 members already indicating their opposition.
What happens on Capitol Hill in the next days may determine whether missiles aimed at Syria are fired and also shape the legacy of Mr Obama, whose authority, at home and abroad, is surely on the line. While the President could theoretically ignore a "no" vote in Congress and order strikes anyway, to do so would almost surely elicit an impeachment effort by conservative and Tea Party Republicans."" (The Independent)
This goes to show that 'people power' can and does make a difference. At the very least – it buys time – and when we are faced by the potential of a global war – time becomes a very precious commodity.
Yes – I've been imagining them regrouping and scrambling to retool this idiocy to sell it – and the word comes down from the overlords "If you don't get your asses in there I'm sicking the Zionists on them – and you! Now move it!" Ha! Gallows humor, I know, but dems de apples…
I would be glad his authority was on the line in a situation like this and although it is obvious he is getting his orders from somewhere that is not 'the people' and it definitely not common sense, then this is a movement of empowerment, not, dis-empowerment. One thing this guy said that has always stuck in my mind ' you can't change the whitehouse from the inside'. Obviously meaning it has to be done by the people from the outside. If the people got more involved instead of being passive gorpers then maybe he could turn out very useful for the people.
The elephant in the room is engulfing the entire house…slowly and steadily. My gut says the NWO's marching orders contain something so horrific, that no one dare say a word after…if they can speak at all. I so wish that my gut feeling is wrong.
Same here…yours and mine..
My sense as well Randall. I think it is naive of us to think that anything on capital hill comes as a surprise to the parasites. This has been scripted for effect. An unusual period of contemplation and restraint designed to heighten the emotional and psychological impact of the next colossal event.
They ´re gonna push something nasty- most probably- BUT they will only create awareness and disgust towards theirselves.
Everything they can accomplish is sadness in the face of agony, but people all over will very soon- if not instantly- look through the ever thinner veil of poor, blatant lies which the Zionists are hastingly and carelessly trying to weave with the employmennt of a prybar.
Their desperation is justified in the ever growing light of truth energy.
The more they push the more people awake and gather for the sake of their lifes!
We are long overdue for the recognition of truth to become mainstream; feels a bit closer but I too suspect it will be derailed by something many times uglier… They will not relinquish control gracefully, they rather sink the ship along with them, other than accept their fate like dark warriors they are. Much love needed.
yes – it's parallel – two worlds reaching maturation, like cell division, only this is kind of light from dark – or the old analogy, wheat from tares (invasive parasitic weeds..)
In 2012 EU sanctions halted British corporates' sale of UK-licensed supplies of sarin gas ingredient to Syria
It is clear that the "Old World Order" is being exposed for the corrupt entity that it is (created that way?), and the "New World Order" is "waiting in the wings"………naw!! can't be, forget what I said.
Okay…it IS 'scary'….but THAT IS THEIR MODUS OPERANDII! Ruling through FEAR!! The classic 'bully' approach with some seriously insidious, means, being used to achieve their 'dark' endgame. All of which is paid for by public monies, while 'they' hike up their own obscene remuneration for distinguished careers in 'BS Propogation'..and misleading their nations and using murder and violence against them. It's disgusting.The PTW are being 'found wanting' in no uncertain terms…they are found to be the real 'bad guys'….THAT changes everything. Many may be reluctant to accept these TRUTHS…but the Human Spirit KNOWS when it is being suppressed and that, 'reluctance to accept' is the 'HOW' of that 'suppression'. It is a HABIT! Give yourselves a 'break', you've been TRAINED TO BE AFRAID…ALL YOUR LIVES! What is 'learned' can be UNLEARNED' It's like everything else…TEMPORARY!! As long as you keep your minds and Hearts OPEN…they can no longer 'fool' you…like Ivana said…ahem: 'Don't get mad….get EVERTYHING' (that you are entitled to as a sovereign Being on their Home planet). Stop believing them, paying them, trusting them or obeying them….your input keeps the 'wheels' greased…time for a full Grease & Oil change ain't it people?
Problem is, as much as we want truth to get out, I imagine that someday it will be used to expose the governments around the world, which will show the world how evil and corrupt our leaders are and get people to see the solution this wonderful new one world government and its savior leader.
Both the poster at the head of this article and the video perpetuate the myth that 911 was done only by Osama bin Laden and a bunch of traitors in the Bush regime. This does not pass the litmus test for being a '911 Truth', because it does not mention the vital Israeli connection.
The Security at the Twin Towers and the Logan Airport in Boston were controlled by an Israeli/Mossad related company. A night watchman at the WTC reported that in the months preceding the attacks, after the cleaning company's fleet of white vans left the WTC in the middle of the night, another fleet of white vans arrived. When he followed them one night to investigate who they were and what they were doing he always found locked doors, and reported hearing the sounds of heavy grinding and industrial activity…
The 911 demolition took months to set up, and the people involved all had connections to the Israeli Security company and Urban Moving Systems, another firm with Israeli connections, who moved out of their offices before the end of their lease – two weeks before the towers were pulverised into dust.
The "Dancing Israelis" and other vans of Israelis arrested with traces of explosives on 911 were also found in Urban Moving Systems white vans. Unaccountably, they were all deported back to Israel without ever facing charges by then Attorney General Mukasey – a Zionist.
Evil does not exist on its own; evil only arises when ignorant, dysfunctional and loveless people misuse their power. ?How is it that these evil people flourish among us – pretending to do good – while all the time manifesting and perpetrating evil?
We in the West are supposed to be the good guys on the world stage, but it is being clearly revealed every day that we in fact are the real terrorists in this world.
It is sad, but true – and terrifying.?
Cognitive Dissonance anyone?
I am beginning to believe that 911 was supposed to trigger some sort of spiritual awakening. A purposeful event to snap so many out of their superficial materialistic slumber.
or "used" to trigger…
Anyone who worked in the trade center was legitimate cannon fodder, when you consider what the WTC actually stood for. We obviously could continue to observe this from a "house of mirrors" perspective, but 911 was not an isolated incident and many more, seemingly insignificant, similar events, have occurred throughout history to spearhead the "tides of change". Was this one as you say "used" yes and no, I would be more inclined to look at it as answering the "final bell", which went off unheard, as shown by the subsequent continuation of the Republican/Democrat dialectic resulting in the "thing" that assumed the "reigns" in the U.S.
Definitely multi-layered, that's for sure. Set up to fail? http://www.zengardner.com/could-911-truth-topple-the-american-empire/
everyone already knows it is the jews, EVERYONe has known it for a while. even if we are ignorant of them doing
911, jfk, patton, ww1, ww2, okc, pretty much everything…
we know in our hearts it is them which is why we turn away because we know the battle to take them down will be so painful and we will have to confront pure evil and even more so confront ourselves.. our weakness, savagry and all our shame.
not so easy for good gentle folk.. aka gentiles.
we gotta ease the work now by making it clear that judiasm is not a race.. but a kind of spiritual supremacists virus. taking away the race part of it will really help people.
we need local leaders taking a stand in every community, speaking out about the jews and confronting them directly while being protected.
this is what will save us and the only way to do it is to ask God for help, just as Jesus did.
The long kiss goodnight movie 1996 speaks of bombing the world trade center killing 4000 people and Alex Jones interviews Aaron Russo who tells of Nickolas Rockefeller informing him 11 months before 9-11 that there was going to be an event to gather public support to attack Afghanistan, Iraq and three other countries.
https://www.youtube.com/watch?v=N1vwjFhF4dA – Trailer – Watch it closely, even the conversation at the end.
https://www.youtube.com/watch?v=LSGZ4Hkdyg4 – Interview with Aaron Russo


text:
Can you provide instructions on necessary settings that I need to apply to my Facebook app created for this plugin?
I haven't created a FB app before and I want to make sure I'm doing it right. At the same time I assume there aren't all that many things that need to be set up for this to work.
Thanks heaps!!!


text:
Vertigo at Redline DTLA
Come meet some of our members and socialize with other gay men who enjoy skiing and snowboarding. You can also learn more about our upcoming Ski Season, with trips to destinations including Mammoth, Aspen and Park City already planned. Potential new members are welcome to check out our club, and enjoy a cocktail at this new Downtown LA bar.
Redline is located at 131 E. 6th St, Los Angeles, and is just four blocks from the Pershing Square Red Line Metro stop.


text:
Ratings based on 31 Verified Reviews
They paid and stayed. We double-checked.
2.0 Room cleanliness
2.2 Service & staff
2.0 Room comfort
1.7 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
by A verified traveler from Louisville, KY
Hotel should be closed until basic care is takenPosted Jul 29, 2015
Pros: NOTHING, except the registration staff was pleasant and understanding.
Cons: Too many things to name. The hotel should be closed.
Location: It is a great location, near interstate and Huntsville.
The hotel staff was very pleasant and did not question my decision to not my decision to not stay at the hotel. I checked two different rooms and the a/c was not cooling at all; the vent covers were missing in both rooms. The owner/manager has obviously not invested anything in the property. It should be closed by the Health Department for basic safety and welfare reason. DO NOT STAY AT THIS HOTEL! Unfortunately it was my first stay with the Country Hearth Inn chain.
for Familiesby Rebecca from Elkhart
Bad choice!Posted Jun 13, 2015 on Hotels
1st off our reservation was not recognized by then, then asked for non smoking but when we walked in the room it was like getting hit in the face with the smell of tobacco!, there was no alarm clock, the beds were hard the pillows were very thin, this was to me a waste of money... I have stay at some very nice places for this price, this one was not one of them
for Business Travelersby A verified traveler
HorridPosted May 7, 2015 on Hotels
Would not honor reservation. Room was disgusting and falling apart.
for Personal Eventby James
Posted May 6, 2015 on Hotels
by A verified traveler from huntsville
Never stay againPosted Mar 29, 2015
Rooms were not clean air system didn't properly work outdated poor customer service room smelled I will never stay their again
for Personal Eventby GAIL from Wisconsin
Yikes!Posted Mar 4, 2015 on Hotels
First and foremost - TERRY was a peach and very helpful, for service I would have given her a 5. However, I ended up at this hotel because I couldn't drive any further and need to sleep. My best word to describe this hotel was YIKES! The bed was comfortable enough... but everything seemed groady (unclean). I really didn't even use the tub because the place was just ... yuck. The breakfast... is a non-breakfast. Do not plan on eating here. I probably wouldn't stay here again.
by A verified traveler from B
Expedia overbooked hotelsPosted Feb 23, 2015
Expedia overbooked on a night of black ice in Alabama and we had no room even with a confirmation number. The clerk behind the counter gave us the only room available which had no heat. We were grateful for that but the room was in bad repair as was the lobby.
by Todd from Dallas
Trashy Hotel Next to InterstatePosted Jun 2, 2014
Pros: Other than my departure, nothing.
Cons: See above
Location: A few
The hotel was the absolute worst I've ever stayed in. The room was filthy (floor not vacuumed, restroom nasty, the door looked like it had been put under a car and had the oil changed on it, etc.). The pool area enclosure looked like an area you'd see behind a building that houses the dumpsters. In regards to the environment created by the other guests, let's just say it was far from minimally acceptable standards. It sounded like a classroom of children were challenged to a 3 hour jumping contest above us. In addition, I thought the headboard from the bed next door was about to break through the wall from the couple having sex. I think they rented the room by the hour and tried to camouflage their noise by blaring the television. In regards to the breakfast, we went across the street to McDonald's both mornings as it was an exponential step-up in quality over what was being served in the lobby. When we arrived their was cold cereal (one option - corn flakes) and that's it. Also because of the condition of the room, performed a thorough check for bedbugs, before even laying my suitcase on the bed
for Business Travelersby Becker
Posted Nov 22, 2013 on Hotels
for Overnight Stay Before Destinationby Rhonda from Athens, AL
Lots of restaurants tochoose fromPosted Aug 7, 2013 on Hotels
The stay was ok...the pool was disgusting and I would not allow my children to swim in it. The young lady that checked us in was very friendly and helpful. The carpet by the bathroom smelled like urine.
Comment from Hotel Management
Jun 21, 2014 by andy, Hotel Management
thank you for your stay with us, we hope we can serve you again in the future, our pool is under construction so hopefully we will give us another chance to meet your needs


text:
- Tickets >
- Concerts Tickets >
- Rap / Hip Hop Tickets >
- Alunageorge Tickets
Alunageorge Tickets
Get ready for Alunageorge, all the way live. Alunageorge is playing this year in many cities . Buy premium Alunageorge tickets and experience the thrill of a live concert with Alunageorge at affordable prices.
Related Cities
|Alunageorge San Francisco
|Alunageorge Portland
|Alunageorge Seattle
|Alunageorge Englewood
|Alunageorge Kansas City
|Alunageorge Philadelphia
|Alunageorge Washington
|Alunageorge Allston
Ticket Buzz:


text:
The development of the joint NASA GSFC and the National Imagery and Mapping Agency (NIMA) Geopotential Model EGM96
National Aeronautics and Space Administration, Goddard Space Flight Center, 1998 - Gravitational potential - 575 pages
From inside the book
52 pages matching stations in this book
Where's the rest of this book?
Results 1-3 of 52
What people are saying - Write a review
We haven't found any reviews in the usual places.
Explorer PlatformExtreme Ultraviolet Explorer EPEUVE
GPSBased EPEUVE Orbit Determination
Independent Solution Calibrations
7 other sections not shown
Other editions - View all
Common terms and phrases
accuracy adjusted Ajisai along-track altimeter data altimeter-derived altimetry areas BE-C Bouguer Bouguer anomalies cell cm/s combination model combination solution comparisons computed constraint covariance coverage cycles data set degree 70 degree and order Doppler DORIS SPOT-2 DTED dynamic ocean topography elevation ellipsoid EP/EUVE EP/EUVE T/P GPS Epoch estimated evaluation Figure free-air anomaly geoid undulation Geophys geopotential model GEOSAT global GPS/MET gravity field gravity model grid GSFC HILAT improvement LAGEOS LAGEOS-2 mean anomalies mean gravity anomalies mGal Nerem NIMA normal equations Optical orbit determination orbit perturbations orbit tests orthometric heights parameters Pavlis predicted priori procedure pseudorange quadrature radial orbit error Rapp reference ellipsoid residual satellite tracking data satellite-only model sea surface SEASAT Section signal SLR data spacecraft spherical harmonic standard deviation Starlette stations Stella surface gravity surface gravity data Table TDRS TDRSS TerrainBase terrestrial tidal tide model TOPEX/POSEIDON values


text:
The Vaccines and Related Biological Products board voted its confidence in the immunogenicity of Heplisav by a 13 – 1 vote; however, the committee said in an 8 – 5 decision, with one abstention, that it could not recommend the vaccine for approval to the FDA due to insufficient clinical safety data, especially in certain minority groups.
A theoretical concern exists that vaccines containing adjuvants (pharmacological agents added to enhance seroprotection) might induce autoimmune diseases, such as multiple sclerosis. Dynavax's drug contains the same Hep-B surface proteins (antigen) as currently marketed HBV vaccines. What has some panel members worried, however, is that Heplisav enjoins a first-in-class adjuvant, which activates immune responses by specifically targeting Toll-like Receptor 9 (TLR-9), found on a specialized subset of immune cells.
However, briefing documents posted by the regulatory agency failed to demonstrate a mechanistic link between the company's TLR-9 agonist and autoimmune response: Pooled results from two pivotal late-stage trials demonstrated the relative risk of developing a serious adverse event in patients treated with Heplisav was no greater than the group injected with the comparator vaccine Engerix-B, marketed by GlaxoSmithKline (GSK).
The risk of African-Americans contracting HBV is three times greater than that of whites. Committee chair Robert Daum, MD, expressed concern "that there's not enough data from different ethnic groups to be sure the immunogenetic response [of heplisav] is adequate."
On average, the ethnicities in the two phase-3 trials containing 4,800 participants were White (87.8%); Black (8.8%); and Hispanic (4.3%). However, it's important to remember that last year blacks and those of Hispanic or Latino origin comprised only 13.1% and 16.7% of the U.S. population, according to U.S. Census Bureau data.
The Advisory Committee did not vote against the approval of the vaccine.
The Advisory Committee voted 8 to 5 that the safety data is insufficient. So there were 5 members that voted clearly for the approval. From the 8 members that voted against the safety data, there were some that voted that a further test could be made POS-approval. I do not know the exact number who voted for that, but I remember to see at least 2 of them. If from 8 members, 2 voted against but accept a POS-approval test, that means that 5+2=7 member are for the approval of the vaccine even if a test is further necessary. That would mean that at maximum 8-2=6 members requested tests pre-approval. In other words the result of the voting was at least 7 for the approval and at maximum 6 against the approval.
In my World EU is a Shoe in*
For the New B*
As always, your clarity is helpful to remind investors this really is as close to a sure thing as one can get in a biotech stock.
" insufficient clinical safety data" What, are they worried about safety? What could possibly go wrong? After all, it's a vaccine and its Heplisav. right?
#1. "[A]re they worried about safety?" Yes, safety. That is what FDA said. Not complicated.
#2. "What could possibly do wrong?" - 1:30,000 or greater chance of an adverse event.
#3. Bottom Line: FDA wants more data to cover their butts in case an ultra-rare 1:30,000 chance of an adverse event occurs - it's a vaccine afterall. Realize, vaccines are some of the safest, if not THE safest, drugs on the planet. The fact that FDA settled on a 8,000 patient study can only demonstrate confidence in the safety profile. Read the FDA's AdComm docs.
Truth Fear.
Are you sure you are not BlackRaven? You sure sound like him!!
Sentiment: Buy


text:
The idea is to give healthcare purchasers a sense of their chances of having a bad outcome, and to give employers more information when they're deciding how to spend their health plan dollars.
Yes, giving discharge instructions, complying with antibiotic selection rules, and giving patients a positive experience – the metrics being rolled out by the Centers for Medicare & Medicaid Services this year —are important.
But the bottom line is what everyone really wants to know. What is the chance a patient might die during or after a pancreatic resection at hospital A versus hospital B? That's what's coming, Binder says.
"This is such powerful data," she says. "We're saying, 'this is your chance of survival if you go to this hospital and have this procedure. That's as raw edged as you can get in terms of transparency."
Take esophageal resection in Massachusetts: At Brigham and Women's Hospital, patients have a 3.29% odds of dying whereas at North Shore Medical Center Salem Hospital, it's 9.78%.
And for pancreatic resection in New Jersey: At John F. Kennedy Medical Center in Edison, patients have an 10.61%, chance of dying, compared with 3.85% at Morristown Memorial.
In fact, the variation among all the hospitals reporting resection survival scores is huge, she says. For esophageal resection over the last two years, the very best hospitals a patient has a 2.9% chance of mortality while at the worst hospitals, the odds are 12.1%. For pancreatic resection, no hospitals are in the best category, but the worst hospitals have death rates at 19% and 21%.
Comments are moderated. Please be patient.


text:
Carson City Health and Human Services aims to protect and improve the quality of life for our … [more]
Next Job Fair is Right Around the Corner!
Attention all jobseekers, an opportunity is coming to Carson City for you to meet your next potential employer! Please join us on September 25, 2015 … Continue Reading
Free Health Services are Coming to Carson City!
The Remote Area Medical (RAM) organization will host a free medical, dental and vision clinic at Carson High School the weekend of October 16-18, … Continue Reading
5 Steps to Receive a Temporary Food Permit
Summer events like the Nevada State Fair are right around the corner. Does your organization know what steps to take in order to receive a temporary … Continue Reading
1(800) QUIT-NOW: A Confidential Resource to Help You Quit Smoking
The Nevada Tobacco Quitline provides FREE one on one counseling to Nevada residents 13 years and older. You and your quit coach will develop an … Continue Reading


text:
Norwegian interests in the Arctic and Antarctic, as well as national and international commitments, means that we have a particular responsibility to promote knowledge that is necessary to exercise a sound management and business activity in the polar regions.
Want to meet other doctoral fellows in climate research? Want some input on how to communicate your research? Want to hear how other doctoral fellows worked to get an ERC Grant? You are invited to The Research Councils input and inspiration-day.
This autumn the Research Council of Norway will compile an overview of national research activities in environmental, climate and polar research. A high response rate from the research community and relevant companies is essential to providing the authorities with a reliable knowledge base for determining future initiatives.
The seminar "The Arctic: Unfurling Research and policy Perspectives" was organized by the Norwegian Embassy in New Delhi in cooperation with the Ministry of Earth Science of India on May 5th.
The Research Council of Norway
P.O Box 564 N-1327 Lysaker, Norway
Visiting address: Drammensveien 288, 0283 Oslo
Telephone: +47 22 03 70 00
E-mail to the programme: email@example.com


text:
Spare5 Inc. has raised $10 million in Series A funding to bring machine learning and big data analytics to crowdsourcing. Read More »
Aug 25, 2015
Spare5 Inc. has raised $10 million in Series A funding to bring machine learning and big data analytics to crowdsourcing. Read More »
In this morning's Web roundup, Olio Devices wins backing for gold smartwatches. Foundry Group closes another $225 million fund. And Uber plans to invest $1 billion in India. Read More »
In this morning's Web roundup, Adaptive Insights raises $75 million. Simply Insured raises funding for its health-insurance service. And Venafi secures funding for software to protect online transactions. Read More »
A startup that wants to make 3-D laser printers that are easy enough to operate and affordable enough for home users, Glowforge Inc., raised $9 million in Series A funding. Read More »
Coca-Cola Founders, a program that Coca-Cola launched last year to work with startups, said one of its portfolio companies has raised a seed round and several others are in talks with investors.
Wonolo Inc., whose name is short for "work now locally," has raised $2.2 million at a valuation of $7.5 million for software that matches short-term corporate jobs with people who have the flexibility to do those jobs on short notice. Read More »
StartUp Health–a New York-based accelerator that dubs itself an 'academy' because of its mutliyear engagement with startups–is offering something new. Companies taking part in StartUp Health now have the potential to raise funding from the organization's syndicate on crowdfunding site AngelList. Read More »
Corporations have rediscovered venture capital, plunging into the industry in search of ideas and products to keep their businesses humming.
But their timing has never been especially good. They jumped in during the dot-com bubble only to head for the hills when things turned sour.
This time out, they seem to be especially interested in early-stage companies and some are behaving like venture firms. Have things changed? Are they in for the long haul?
Brad Feld, a partner at venture capital firm Foundry Group who has seen the ups and downs of corporate venturing, advises startups to understand that corporations always act in their own self-interest. Read More »
Ello Pbc., an ad-free social network that pledged to never sell user data, has made its philosophy binding and secured funding from investors who agree with its approach to make money other ways. Read More »
Striking a rare win in the male-dominated gaming sector, female-focused mobile gaming startup Nix Hydra Inc. has raised $5 million from Foundry Group to expand its hit game "Egg Baby" and launch new ones.
Co-founded in 2012 by former Yale classmates and startup vets Naomi Ladizinsky and Lina Chen, the Los Angeles-based startup is unapologetically focused on creating games by women and for women. Read More »
Beats Music, the on-demand music service launched by high-profile headphones company Beats Electronics LLC, will now add a new offering geared toward musicians: a way to communicate with fans and sell merchandise and albums.
Beats Music will acquire Topspin Media Inc., a company whose platform is used by some 55,000 musicians and performers seeking to stay engaged with their fans.
Terms of the transaction were not disclosed. Beats Music and Topspin both announed the deal via blog entries on their websites. Attempts to reach both companies were not immediately successful. Read More »
Produced by the editors of Dow Jones VentureWire, Venture Capital Dispatch tracks the fast-moving developments at the intersection of high-tech innovation and venture capital finance. Featuring the VentureWire reporting team in the Silicon Valley, New York, Boston and Shanghai tech centers, Venture Capital Dispatch provides insight into the newest start-ups and latest trends in venture capital investing. Write us at firstname.lastname@example.com. For more information on Dow Jones products covering venture capital and other financial markets, go to http://pevc.dowjones.com.


text:
Exclusive finds with a new theme each month.
Shop: Pop-In
Our director of creative projects shares what she's into.
Read More
Stay updated with a steady stream of new info.
Live Chat or call 1.888.282.6060.
Pure wool adds some texture to a handsome, modern suit featuring a two-button, notch-lapel jacket and flat-front trousers.
Watch the video: Men's Suits and Sportcoats


text:
Page 1
Original Article
Quetiapine with lithium or divalproex for the
treatment of bipolar mania: a randomized,
double-blind, placebo-controlled study
Sachs G, Chengappa KNR, Suppes T, Mullen JA, Brecher M,
Devine NA, Sweitzer DE. Quetiapine with lithium or divalproex for
the treatment of bipolar mania: a randomized, double-blind,
placebo-controlled study.
Bipolar Disord 2004: 6: 213–223. ª Blackwell Munksgaard, 2004
Objective: Evaluate the efficacy and tolerability of quetiapine (QTP)
combined with lithium (Li) or divalproex (DVP) in the treatment of acute
Methods: Patients were randomized to 21 days of double-blind
treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP.
QTP was rapidly dosed up to a maximum of 800 mg/day; Li was dosed
to 0.7–1.0 mEq/L; or DVP to 50–100 lg/mL.
Results: Fifty-six of 91 (61.5%) individuals in the QTP + Li/DVP
group compared with 49 of 100 (49%) taking PBO + Li/DVP completed
the study. A significantly greater mean reduction in total Young Mania
Rating Scale (YMRS) score was observed at end-point in patients
receiving QTP + Li/DVP compared with those in the PBO + Li/DVP
group ()13.76 versus )9.93; p ¼ 0.021). The response rate (‡50% YMRS
improvement) was significantly higher in the QTP + Li/DVP group
than in PBO + Li/DVP-treated patients (54.3% versus 32.6%;
p ¼ 0.005), as was the proportion of patients achieving clinical remission
(YMRS < 12) (45.7% versus 25.8%; p ¼ 0.007). Patients receiving
QTP + Li/DVP also had a significantly greater improvement in Clinical
Global Impressions-Bipolar (CGI-BP) Severity of Illness scores ()1.38
versus )0.78; p ¼ 0.001). The mean last-week dose of QTP was 584 mg/
day in patients meeting response criteria. Common adverse events (at
least 10% and twice the rate of Li/DVP) in the QTP + Li/DVP group
included somnolence, dry mouth, asthenia, and postural hypotension.
Conclusions: Quetiapine combined with either Li or DVP has
superior efficacy compared with Li or DVP monotherapy for treating
patients with bipolar mania. Combination therapy was well-tolerated
and most adverse events were mild, withdrawal because of adverse
events being only 5% compared with 6% on Li or DVP
G Sachsa, KNR Chengappab,
T Suppesc, JA Mullend, M Brecherd,
NA Devinedand DE Sweitzerd
aHarvard Bipolar Research Program, Boston, MA,
bWestern Psychiatric Institute and Clinic, University
of Pittsburgh Medical Center, Pittsburgh, PA,
cUniversity of Texas Southwestern Medical Center,
Dallas, TX,dAstraZeneca, Wilmington, DE, USA
Key words: bipolar disorder – combination
therapy – divalproex – lithium – mania – quetiapine
Received 4 September 2003, revised and
accepted for publication 19 February 2004
Corresponding author: Gary Sachs, MD, Harvard
Bipolar Research Program, Massachusetts General
Hospital, 50 Staniford St, 5th Floor, Boston,
MA 02114, USA. Fax: 617-726-6768;
e-mail: email@example.com
G Sachs: Consultant for Abbott Laboratories, Janssen Pharmaceutica, Novartis, Eli Lilly and Company, Bristol-Myers Squibb, Glaxo SmithKline
Pharmaceuticals, Elan, Sanofi, Sigma-Tau, AstraZeneca Pharmaceuticals; Grant Support from Abbott Laboratories, Janssen Pharmaceutica;
Honoraria from Abbott Laboratories, Glaxo SmithKline Pharmaceuticals, Janssen Pharmaceutica, Eli Lilly and Company, Bristol-Myers Squibb,
Solvay, Novartis, Sanofi, AstraZeneca Pharmaceuticals, Pfizer Inc; Stockholder – none. KNR Chengappa: has received grant/research support from
Ortho McNeil and Janssen Pharmaceutica, and serves on the speakers bureau for AstraZeneca, Eli Lilly, Janssen, and Ortho McNeil. T Suppes:
Sources of funding for clinical grants – Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, Glaxo SmithKline Pharmaceuticals, Janssen
Pharmaceutica, National Institute of Mental Health, Novartis, Robert Wood Johnson Pharmaceutical Research Institute, The Stanley Medical
Bipolar Disorders 2004: 6: 213–223
Copyright ª Blackwell Munksgaard 2004
Page 2
Bipolar disorder is a prevalent and severe mental
illness characterized by debilitating mood swings
from intense euphoria to depression. The symp-
toms of mania associated with bipolar I disorder
are severe, interfere with the capacity to function
effectively in work or social settings, and often
require hospitalization (1).
While there is currently no cure for bipolar
disorder a number of agents are now available that
substantially decrease the morbidity of manic
episodes. Unfortunately, many patients do not
fully respond to these agents or are unable to
tolerate their side effects, contributing to poor
levels of adherence to medication (2). Effective
agents with improved tolerability that target a
broad range of symptoms associated with mania,
with substantial clinical efficacy, are needed.
Therefore, the ongoing development of new treat-
ment options to address the needs of patients and
physicians remains important.
The primary aim in the treatment of mania is
to rapidly control symptoms while minimizing
unwanted side effects. Currently, the first-line
approach to treatment of severe manic or mixed
episodes is the initiation of lithium (Li) or dival-
proex (DVP) in combination with an antipsychotic
(3, 4). For less ill patients, monotherapy with Li,
DVP, or an antipsychotic is recommended (3). For
those who do not fully respond to monotherapy,
the addition of an antipsychotic is the next-line
recommendation. In clinical practice this means
that combination or adjunct therapy is the norm,
not the exception, especially in the context of
short-duration hospital stays.
In most cases, atypical antipsychotics as a class
are preferred over typical antipsychotics because
they offer equivalent efficacy with a more benign
side effect profile than typical agents (3). However,
it cannot be assumed that newer atypical anti-
psychotic agents are effective either as mono-
therapy or in combination with other agents.
Tolerability is of particular concern when combi-
nation therapy is used, as an increased risk from
cumulative adverse effects, although not always
observed, might be expected (5, 6).
A growing body of literature and clinical experi-
ence suggests that the atypical antipsychotic que-
tiapine (QTP) is efficacious and well-tolerated for
the treatment of mania. Several open-label and
retrospective studies indicate that QTP is effective
and well-tolerated in the treatment of bipolar
mania in adults both as monotherapy and in
combination with standard agents (7–11). One
small, double-blind, randomized, controlled study
has provided preliminary evidence for the efficacy
of QTP, when added to ongoing DVP treatment, in
significantly improving manic, depressive, and
psychotic symptoms in adolescent patients with
bipolar disorder (12).
Despite being a recommended approach (3, 4),
few large, randomized, and adequately controlled
studies have examined the safety and efficacy of
atypical antipsychotics in combination with stan-
dard agents for the treatment of acute mania (13,
14). These studies support the hypothesis that an
atypical antipsychotic in combination with Li or
DVP is more effective than Li or DVP monothera-
py in the treatment of acute mania. The trial
presented here evaluates the efficacy of QTP as
combination therapy with Li or DVP in bipolar
This 3-week, double-blind, randomized, parallel-
group, placebo (PBO)-controlled study of QTP in
combination with Li or DVP was conducted at
27 sites in the United States. The study protocol
was reviewed and approved by the appropriate
institutional review board in accordance with the
standards and guidelines established in the current
amendment of the Declaration of Helsinki, and
consistent with good clinical practice and applic-
able regulatory requirements. Written informed
consent was obtained from all patients prior to any
study-related activities.
Patient selection
Adult patients (‡18 years) hospitalized for a DSM-
IV diagnosis of bipolar I disorder, most recent
episode manic, who had been treated with Li or
DVP for at least 7 of the 28 days immediately prior
to randomization (day 1) were eligible for selection.
A history of at least one documented manic or
mixed episode prior to the episode responsible for
the current hospitalization was required for selec-
tion. At screening and randomization, subjects
were selected who had a Young Mania Rating
Scale (YMRS) score of at least 20, with a score of
Research Institute; Consulting agreements/advisory boards – AstraZeneca, Bristol-Myers Squibb, Eli Lilly Research Laboratories, Glaxo
SmithKline Pharmaceuticals, Janssen Pharmaceutica, Johnson & Johnson Pharmaceutical Research & Development, Pfizer, Pharmaceutical
Research Institute (PRI), Ortho McNeil Pharmaceutical, UCB Pharma, Novartis Pharmaceuticals; Financial interests/stock ownership – none. JA
Mullen, M Brecher, NA Devine, DE Sweitzer are all employees of AstraZeneca Pharmaceuticals.
Sachs et al.
Page 3
at least 4 on two of the four core YMRS items of
irritability, speech, content, and disruptive/aggres-
sive behavior. Patients were also required to have a
score of at least 4 for overall bipolar illness on the
Clinical Global Impressions-Bipolar (CGI-BP)
Severity of Illness scale.
Exclusion criteria
Pregnant or lactating women and those of child-
bearing potential not using a reliable method of
contraception were excluded from participating in
the study. Patients whose current manic episode
was due to a medical condition were also excluded.
Other patients who were excluded were those
meeting DSM-IV criteria for rapid cycling, those
who had required hospitalization for 3 or more
weeks for the index manic episode, or those with
known intolerance or lack of response to QTP or
clozapine. The continuous daily use of benzodiaze-
pines, in excess of 4 mg/day of lorazepam or the
equivalent, was also not allowed during the month
preceding screening. Patients requiring the use of
antihypertensive medications, unless stable for at
least 1 month, or the use of antidepressants during
the screening period (day )7 to 1) or within a
period of five half-lives of the drug prior to study
randomization, were also ineligible. The use of
depot haloperidol and fluphenazine (within one
injection cycle), and certain cytochrome P450 3A4
inhibitors and inducers, thioridazine, or any
experimental drugs within 2 weeks prior to ran-
domization was not permitted. Also excluded were
patients who had a history of clinically significant
medical disease.
Study procedure
Eligible subjects underwent assessments in the
7 days prior to randomization that included a
complete medical and psychiatric history, inclu-
ding YMRS and the CGI-BP Severity of Illness
assessments, a complete physical examination, vital
signs including weight, hematologic and clinical
chemistry testing, thyroid function tests, and a
12-lead electrocardiogram (ECG).
Patients who met selection criteria began or
continued treatment with Li or DVP on or before
day 1 (randomization). Assignment and dose
adjustments to either Li or DVP were based on
medical criteria, including previous response if
known, and clinician discretion in order to achieve
symptom control, minimize side effects, and
achieve target trough serum concentrations of Li
and DVP within the established therapeutic range
(0.7–1.0 mEq/L Li or 50–100 lg/mL DVP).
Quetiapine was administered twice daily (morn-
PBO, in a double-blind fashion. Investigators
remained blinded to study treatment throughout
thetrial.Initial target doseswere100 mg/dayatday
1, 200 mg/day at day 2, 300 mg/day at day 3, and
400 mg/day at day 4. The dose of QTP was adjusted
600 mg/day at day 5, and 200 and 800 mg/day at
days 6to 21. Guidelines discouraged clinicians from
of at least 600 mg/day QTP had been attempted.
Lorazepam, zolpidem, chloral hydrate, and zale-
plon within specified dose limitations were allowed
during the study. The maximum permissible doses
for lorazepam were 6 mg/day from screening to the
day prior to randomization, 4 mg/day from days 1
to 4, 2 mg/day from days 5 to 7, and 1 mg/day from
days 8 to 10, after which lorazepam was not
allowed. Only one sleep medication was allowed
per day throughout the trial, with a maximum dose
of 10 mg/day zolpidem; chloral hydrate 2 g/day
from days 1 to 7, then 1 g/day; and 20 mg/day
zaleplon. If necessary, intramuscular haloperidol
could be used for severe agitation, but only during
the screening period.
Patients were required to remain in the hospital
for the first 7 days of the randomized period. After
this time, they could be treated as either inpatients
or outpatients as clinically indicated.
Study assessments
Assessments and vital sign measurements were
performed at baseline (day 1) and at days 4, 7, 10,
14, and 21. The primary efficacy variable was the
change from baseline in YMRS total score at the
final assessment (15).
Secondary efficacy variables included YMRS
response rate, defined as the percentage of patients
with ‡50% decrease from baseline in the YMRS
score; clinical remission, defined as an end-point
YMRS score £12 (16); change from baseline in
CGI-BP Severity of Illness score (17); CGI-BP
Global Improvement scale score; MADRS total
score (18); Positive and Negative Syndrome Scale
(PANSS) total score (19); PANSS Activation
subscale score; PANSS Supplemental Aggression
Risk subscale score (20); and Global Assessment
Scale (GAS) score (21).
Scales for the assessment of neurologic adverse
events included the modified Simpson-Angus Scale
(SAS) (22) and the Barnes Akathisia Rating
(BARS) Scale (23).
The rate of treatment-emergent depression was
also monitored, defined as a Montgomery-Asberg
Quetiapine combination therapy in bipolar mania
Page 4
Depression Rating Scale (MADRS) score ‡18, with
an increase from baseline of ‡4 at any two
consecutive assessments or at the last observation.
Patients were examined and questioned on all
study days regarding any adverse events. Safety
concomitant medication records, change from
baseline to day 21 in clinical laboratory assessments
(including hematology and chemistry), vital signs,
ECG, physical examination, and weight. Adverse
events included any treatment-emergent symptoms
clinically significant changes in laboratory tests,
vital signs, weight, or ECG.
Statistical analysis
Statistical analyses were performed using the
efficacy and safety populations. The safety popu-
lation included all randomized patients who
received at least one dose of study drug. All
patients who received at least one dose of study
medication and at least one postbaseline efficacy
assessment were included in the intent-to-treat
(ITT) population. Data were analyzed using a last
observation carried forward (LOCF) method.
ANCOVA was used to compare changes from
baseline on the YMRS, MADRS, and PANSS
scales, with the baseline values and clinician-
chosen mood-stabilizer
outcomes were analyzed with Cochran-Mantel-
Haenszel techniques or logistic regression (strati-
fied by clinician-assigned Li or DVP). All statistical
tests were 2-tailed with a significance level of 0.05.
as covariates.Binary
Patient characteristics
One hundred ninety-one patients were randomly
assigned to QTP (n ¼ 91) or PBO (n ¼ 100). One
patient in the QTP group discontinued prior to
receiving treatment. Overall discontinuations after
beginning treatment, including discontinuations
for adverse events, were more frequent in the
PBO group (51.0%) than the QTP group (37.8%)
(p ¼ 0.073). Of the 191 randomized patients, 81
and 89 in the QTP and PBO groups, respectively,
were included in the ITT population (Fig. 1).
Patients from one complete center were exclu-
ded from the ITT analysis because of a center-
specific protocol violation. Baseline demographics
(Table 1) and episode characteristics (Table 2)
were comparable in each of the ITT groups. The
mean age at onset of bipolar disorder for all
patients was 23.3 years. The two treatment groups
had a similar proportion of patients diagnosed as
having bipolar disorder, characterized as moder-
ate, severe without psychotic features, or severe
with psychotic features.
Almost all patients were treated with a mood-
stabilizer prior to randomization. In each treat-
ment combination, approximately half of the
patients had taken their trial mood-stabilizer for
22 or more days prior to randomization (50%
QTP + Li; 48.6% PBO + Li; 51.0% QTP +
DVP; 55.8% PBO + DVP). Few patients began
mood-stabilizer treatment at randomization: one
patient in the QTP + Li arm; one in the PBO +
Li arm; two in the QTP + DVP arm; and four in
the PBO + DVP arm. Only one patient (receiving
PBO + DVP) had not been treated with mood-
stabilizer prior to randomization.
A comparable number of subjects in each
randomized arm received either Li or DVP: 35
patients received Li and 55 received DVP in the
QTP group, while in the PBO group 42 patients
received Li and 58 DVP.
The mean last-week dose in all patients receiving
QTP was 504 mg/day. Among responders, the
mean last-weekdose
received ‡400 mg/day and 59% received ‡600 mg/
was 584 mg/day:91%
Fig. 1. Disposition of study population.
Sachs et al.
Page 5
day. Mean serum concentrations of DVP and Li in
the QTP-treated (day 21: DVP 65 lg/mL; Li
0.78 mEq/L) and PBO-treated groups (day 21:
DVP 65 lg/mL; Li 0.71 mEq/L) were clinically
Over the 3-week double-blind period, median Li
between 0.67 (day 4) and 0.85 mEq/L (day 21) in
the QTP group, and between 0.70 (day 4) and
0.80 mEq/L (days 10 and 14) in the PBO group.
Median valproate serum levels ranged between 68
(days 10 and 14) and 72 lg/mL (day 21) in the QTP
group, and between 82 (day 10) and 66 lg/mL (day
21) in the PBO group. There was no significant
difference in mean Li or DVP serum levels between
the QTP and PBO groups at any visit.
Known prior therapeutic responses to Li and
DVP indicated that 78.2% of patients in the QTP
group and 81.0% of PBO-treated patients receiving
Li during the study had previously shown minimal
to much improvement with Li. Among these
Li-treated patients, 18.8% in the QTP group and
16.2% in the PBO group had an unknown prior
response to Li. Of patients chosen to receive DVP
at randomization, 71.5% and 76.9% previously
showed at least a minimal response to DVP, while
prior response was unknown in 22.4% and 17.3%
in the QTP and PBO groups, respectively. No
patients were known to have deteriorated on Li or
DVP in the past and few (four in each treatment
group) were known to have not responded to their
study mood-stabilizer in the past.
Lorazepam use was limited and consistent with
protocol requirements. The trend for greater use of
lorazepam in the PBO + Li/DVP group from days
3 to 10 did not reach statistical significance
(p ¼ 0.371). Overall, there was no statistical dif-
ference between groups in the use of sleep medi-
cations during the study (p ¼ 0.283).
Patients treated with QTP and Li/DVP showed
significantly greater improvement (p ¼ 0.021) at
day 21 in YMRS score from baseline to end-point
compared with patients treated with PBO + Li/
DVP (Table 3). Mean scores on 10 of the 11
individual YMRS item scores were reduced more
in the QTP than in the PBO group and showed at
least a 1-point change from baseline. Items on the
YMRS that showed the greatest change from
baseline at end-point in the QTP + Li/DVP
group, and the most differentiation versus PBO,
included irritability (mean change )1.6 versus
)0.7), disruptive/aggressive behavior ()1.6 versus
)0.7), sleep ()1.2 versus )0.6), and increased
motor activity ()1.4 versus )0.9), respectively.
The YMRS response rate at day 21 was signi-
ficantly greater for QTP-treated patients than for
those receiving Li/DVP alone (54.3% versus
32.6%; p ¼ 0.005). Response rates in patients
receiving a combination of QTP and Li (56.3%)
or QTP and DVP (53.1%) were similar. In patients
randomized to PBO, the response rate in those
receiving DVP versus Li was 36.5% versus 27.0%.
The differences were not analyzed statistically as
the study was not prospectively powered to com-
pare Li with DVP within each treatment group.
There were no statistically significant differences
in the percentage of patients achieving a YMRS
responsewith QTP combination
patients who reported somnolence compared with
those who did not (59% and 51%, respectively).
In addition, there was no statistically signifi-
cant interaction between the treatment effect, as
Table 1. Baseline demographics and clinical characteristics (ITT, LOCF)
(n ¼ 81)
(n ¼ 89)
(n ¼ 170)
Gender (n)
Age (year)
Weight (kg)
BMI (kg/m2)
BMI ¼ body mass index; ITT ¼ intent-to-treat; LOCF ¼ last
observation carried forward.
Table 2. Baseline disease criteria (ITT, LOCF)
(n ¼ 81)
(n ¼ 89)
(n ¼ 170)
Mean YMRS
Episode type (%)a
Manic moderate
Manic severe without
psychotic features
Manic severe with
psychotic featuresb
Known duration of
illness (mean years)
Number of manic/mixed
episodes during
lifetime (median)
past year (median)
Number of depressive
episodes during
lifetime (median)
past year (median)
31.5 31.131.3
41.942.6 42.4
17.6 18.0 17.8
aEpisode type by DSM-IV criteria.
bIncludes three patients with mixed episodes.
YMRS ¼ Young
LOCF ¼ last observation carried forward.
Mania RatingScale; ITT ¼ intent-to-treat;
Quetiapine combination therapy in bipolar mania


text:
BOSTON -- The last time Andrew Shaw was in TD Garden's visiting locker room, he was guzzling champagne and sporting a gash on his face that would be severely swollen by the next morning.
Considering what the Chicago Blackhawks had just done, however, Shaw could deal with the pain.
"After we won, who cares what you feel like?" Shaw said of that Game 6, when the Blackhawks beat the Boston Bruins and claimed their second Stanley Cup in the past four seasons. "You just created a memory you'll have the rest of your life."
[MORE: Relive the Blackhawks' road to the 2013 Stanley Cup]
Those memories came rushing back to the Blackhawks on Thursday, when they returned to Boston for the first time since that sweltering yet jubilant June night. This game isn't quite as monumental as that one, yet it still has its importance as the Blackhawks try to better their situation in the Western Conference standings.
Corey Crawford was also going down memory lane, especially when the team was headed to its hotel on Wednesday. Crawford came away from last season vindicated after hearing so much criticism, but that wasn't what mattered to him.
"I think there's more satisfaction working hard my whole career and making it to this level and actually winning. That's more satisfaction than proving someone who really hasn't played the game wrong or hasn't been around to watch me in my career. It's just about winning and enjoying it with my family and teammates. That's what it's all about."
[RELATED: Blackhawks' first trip back to Boston since Stanley Cup win]
Joel Quenneville had his moments, too.
"Certainly some great memories; a great night, an amazing ending and a lot of good memories for sure. We expect a dangerous team on the other side; (the Bruins) are playing extremely well. But we had good energy in the morning skate, for sure."
That's understandable. The Blackhawks need to channel that energy onto the ice and try to get on a winning streak again. Their opponent has had no problem in the latter category, as the Bruins rattled off 12 consecutive victories before they lost to Montreal in a shootout on Monday.
[ALSO: Army vet Rico Roman back from Sochi with sled hockey gold]
The Blackhawks have their focus set for tonight: every point is critical at this juncture. But there's no doubt they're extra motivated by what they did here a few months ago.
"Obviously there are some good memories here," Shaw said. "We want to keep them going into tonight's game."


text:
Hi there,
we use cookies to improve your experience on our website. You can
update your settings
by clicking the Cookie Policy link at the bottom of the page.
Has books in several languages as well as US newspapers.
A tiny shop with secondhand books, mostly in Spanish.
A simple corner shop in La Sabana carries fabric from all over the world, including a decent selection of hand-loomed Guatemalan textiles. Prices are reasonable.
Costa Rica's best bookstore chain, with an excellent selection of books in English, including natural history, fiction, cooking and guidebooks.
The selection of crafts is crude, but you're here for one reason, and one reason only: to buy an authentic Tico cowboy hat. Saddle up and ride!
A great farmers' market is held on Fridays behind Taller Lalo Alfaro, where you can grab homemade snacks, queso palmito (a local cheese) and lots of produce.
Subscribe now
and receive a
20% discount
on your next guidebook purchase
Lonely Planet. All rights reserved. No part of this site may be reproduced without our written permission.


text:
Grace's Group
Funding via Nke-Anyi Farmers Multipurpose Cooperative Society Limited (Nke-Anyi FMCS)
She has been borrowing from LAPO to support her business for the past three years. Life is a little better than when she was not borrowing from LAPO.
Gbemisola has been in this business for the past 10 years and she lives in Agege, here in Lagos. Gbemisola is 49 years old and she is soliciting for a loan of N100,000 to purchase more provision and cosmetics to sell. She says thanks.
Success!! The loan was 100% repaid