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Publications (95)325.03 Total impact
Article: Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells[Show abstract] [Hide abstract]
ABSTRACT: Rosemary (Rosmarinus officinalis L.) has been used since ancient times in traditional medicine, while nowadays various rosemary formulations are increasingly exploited by alternative medicine to cure or prevent a wide range of health disorders. Rosemary's bioproperties have prompted scientific investigation, which allowed us to ascertain antioxidant, anti-inflammatory, cytostatic, and cytotoxic activities of crude extracts or of pure components. Although there is a growing body of experimental work, information about rosemary's anticancer properties, such as chemoprotective or anti-proliferative effects on cancer cells, is very poor, especially concerning the mechanism of action. Melanoma is a skin tumor whose diffusion is rapidly increasing in the world and whose malignancy is reinforced by its high resistance to cytotoxic agents; hence the availability of new cytotoxic drugs would be very helpful to improve melanoma prognosis. Here we report on the effect of a rosemary hydroalcoholic extract on the viability of the human melanoma A375 cell line. Main components of rosemary extract were identified by liquid chromatography coupled to tandem mass spectrometry (LC/ESI-MS/MS) and the effect of the crude extract or of pure components on the proliferation of cancer cells was tested by MTT and Trypan blue assays. The effect on cell cycle was investigated by using flow cytometry, and the alteration of the cellular redox state was evaluated by intracellular ROS levels and protein carbonylation analysis. Furthermore, in order to get information about the molecular mechanisms of cytotoxicity, a comparative proteomic investigation was performed.PLoS ONE 07/2015; 10(7):e0132439. DOI:10.1371/journal.pone.0132439 · 3.23 Impact Factor
Article: Nuclear accumulation of mRNAs underlies G4C2 repeat-induced translational repression in a cellular model of C9orf72 ALS[Show abstract] [Hide abstract]
ABSTRACT: A common feature of non-coding repeat expansion disorders is the accumulation of RNA repeats as RNA foci in the nucleus and/or cytoplasm of affected cells. These RNA foci can be toxic by sequestering RNA-binding proteins, thus affecting various steps of post-transcriptional gene regulation. However, the precise step that is affected by C9orf72 GGGGCC (G4C2) repeat expansion, the major genetic cause of Amyotrophic Lateral Sclerosis, is still poorly defined. In this work, we set out to characterise these mechanisms by identifying C9orf72 RNA binding proteins. Sequestration of some of these factors into RNA foci was observed when a (G4C2)31 repeat was expressed in NSC34 and HeLa cells. Most notably, (G4C2)31 repeats widely affected the distribution of Pur-alpha and its binding partner FMRP, which accumulate in intra-cytosolic granules that are positive for stress granules markers. Accordingly, translational repression is induced. Interestingly, this effect is associated to a marked accumulation of poly(A) mRNAs in cell nuclei. Thus, defective trafficking of mRNA, as a consequence of impaired nuclear mRNA export, might affect translation efficiency and contribute to the pathogenesis of C9orf72 ALS.Journal of Cell Science 03/2015; 128(9). DOI:10.1242/jcs.165332 · 5.43 Impact Factor
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ABSTRACT: Microglia are resident macrophages in the central nervous system, whose participation against exogenous injuries and infections is mainly marked by an immediate release of inflammatory cytokines along with a toxic efflux of superoxide radicals. Indeed, many lines of evidence indicate that persistent activation of these cells turns their neuroprotective phenotype into a neurotoxic one, which contributes to destroy neuronal activity and induces neuronal loss in several neurodegeneration processes, such as Alzheimer's disease. In this study we attempted to fill-in the gap in our knowledge about redox regulation of amyloid activated microglia. With this aim, we carried out a robust and comprehensive characterization of the reversibly redox modified proteome both at the level of resting and amyloid-activated BV2 cells, an immortalised cell line of murine microglia. The approach we used combined the selective enrichment of reversible redox modified proteins through a biotin bait with nanoscale liquid chromatography tandem mass spectrometry of their proteolytic peptides. By this reliable approach, we identified 60 proteins changing the redox status of their selective cysteine residues upon treatment with the amyloidogenic Aβ25-35 peptide. These results assessed that in microglia stimulated by amyloids, redox modifications of the proteome specifically target proteins involved in crucial cell processes, i.e. those involved in the protein synthesis. In particular, for peroxiredoxin-6 (Prdx6) and Ras-related C3 botulinum toxin substrate 1 (Rac1) we suggest mechanisms through which reversible redox modifications could affect the peculiar role of microglia in amyloidogenic injury, which at the same time reinforce the oxidative burst and resist toward it. Moreover, the redox modulation we observed on chloride intracellular channel protein 1 (CLIC1) strengthens the structural and functional relationship between the oxidative stress and the metamorphic transition of this protein from a soluble form to an integral membrane form. The redox signatures we determined might also provide neurologists with more specific and reliable biomarkers to distinguish the diverse microglia status in neurodegeneration and then to drive targeted drug design.Molecular BioSystems 03/2015; 11(6). DOI:10.1039/c4mb00703d · 3.21 Impact Factor
Article: Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid[Show abstract] [Hide abstract]
ABSTRACT: Microglia are macrophages within the central nervous system playing a central role in neurodegenerative disorders. Although the initial engagement of microglia seems to be neuroprotective, many lines of evidence indicate that its persistent activation contributes to dismantle neuronal activity and to induce neuronal loss. The molecular pathways that lead from amyloid interaction with membrane receptors to the microglial activation have been extensively investigated, although a definitive picture is not yet at hand. In this work, primary and immortalised microglial cells were treated with a synthetic form of Aß peptides, and relative abundance of acetylated and phosphorylated STAT3 were assayed. Results highlight, for the first time, three distinctive sequential events: i) an earlier event marked by the increase in the level of STAT3 acetylated species, followed by ii) a later increase in the level of STAT3 phosphorylated form, and finally iii) an involvement of phosphorylated STAT3 in the increase in expression of the 14-3-3 epsilon, a protein frequently associated with neurodegenerative diseases and known to be a marker of Aß-activated microglia. These data outline a complex, time-dependent modification of STAT3 signalling triggered by amyloid in the microglial compartments, that once confirmated by in vivo experiments will broad knowledge of the molecular basis of amyloid neurotoxicity.Neurochemistry International 01/2015; 81. DOI:10.1016/j.neuint.2015.01.007 · 3.09 Impact Factor
Article: Mutant PrPCJD prevails over wild-type PrPCJD in the brain of V210I and R208H genetic Creutzfeldt–Jakob disease patients[Show abstract] [Hide abstract]
ABSTRACT: Creutzfeldt–Jakob disease (CJD) is a neurodegenerative disorder characterized by the deposition of the pathological conformer (PrPCJD) of the host encoded cellular prion protein (PrPC). In genetic CJD associated with V210I or R208H PrP substitutions, the pathogenic role of mutant residues is still poorly understood. To understand how V210I or R208H PrP mutations facilitate the development of the disease, we determined by mass spectrometry the quantitative ratio of mutant/wild-type PrPCJD allotypes in brains from affected subjects. We found that the mutant PrPCJD allotypes moderately exceeds of 2- or 3-fold the amount of the wild-type counterpart suggesting that these mutations mainly exert their pathogenic effect on the onset of the pathogenic cascade.Biochemical and Biophysical Research Communications 10/2014; 454(2). DOI:10.1016/j.bbrc.2014.10.051 · 2.30 Impact Factor
Article: Redox proteomics analysis of HNE-modified proteins in DS brain: clues for understanding development of Alzheimer disease.[Show abstract] [Hide abstract]
ABSTRACT: Down syndrome (DS) is the most common genetic cause of intellectual disability, due to partial or complete triplication of chromosome 21. DS subjects are characterized by a number of abnormalities including premature aging and development of Alzheimer's disease (AD) neuropathology after approximately 40 years of age. Several studies show that oxidative stress plays a crucial role in the development of neurodegeneration in DS population. Increased lipid peroxidation is one of the main events causing redox imbalance within cells through the formation of toxic aldehydes that easily react with DNA, lipids and proteins. In this study we used a redox proteomics approach to identify specific targets of 4-hydroxynonenal modifications in the frontal cortex from DS cases, with and without AD pathology. We suggest that a group of identified proteins followed a specific pattern of oxidation in DS vs. young controls (CTRY), likely indicating characteristic features of DS phenotype; a second group of identified proteins showed increased oxidation in DS/AD vs. DS, thus possibly playing a role in the development of AD. The third group of comparison, DS/AD vs. old controls (CTRO), identified proteins that may be considered specific markers of AD pathology. All the identified proteins are involved in important biological functions including intracellular quality control systems, cytoskeleton network, energy metabolism and antioxidant response. Our results demonstrate that oxidative damage is an early event in DS, as well as dysfunctions of protein degradation systems and cellular protective pathways, suggesting that DS subjects are more vulnerable to oxidative damage accumulation that might contribute to AD development. Further, considering that the majority of proteins have been already demonstrated to be oxidized in AD brain, our results strongly support similarities with AD in DS.Free Radical Biology and Medicine 03/2014; 71. DOI:10.1016/j.freeradbiomed.2014.03.027 · 5.74 Impact Factor
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ABSTRACT: The development of plant root systems is characterized by a high plasticity, made possible by the continual propagation of new meristems. Root architecture is fundamental for overall plant growth, abiotic stress resistance, nutrient uptake and response to environmental changes. Understanding the function of genes and proteins which control root architecture and/or stress resistance will contribute to develop more sustainable systems of intensified crop production. To meet these challenges, proteomics provides the genome-wide scale characterization of protein expression pattern, subcellular localization, post-translational modifications, activity regulation and molecular interactions. In this review, we describe a variety of proteomic strategies that have been applied to study the proteome of the whole organ and of specific cell-types during root development. Each has advantages and limitations, but collectively they are providing important insights into the mechanisms by which auxin structures and patterns the root system, and on the interplay between signaling networks, auxin transport and growth. The acquisition of proteomic, transcriptomic and metabolomic datasets of the root apex on the cell scale has revealed the high spatial complexity of regulatory networks, and fosters the use of new powerful proteomic tools for a full understanding of the control of root developmental processes and environmental responses.Journal of Proteome Research 09/2013; 12(11). DOI:10.1021/pr400697s · 4.25 Impact Factor
Article: Involvement of Oxidative Stress in Occurrence of Relapses in Multiple Sclerosis: The Spectrum of Oxidatively Modified Serum Proteins Detected by Proteomics and Redox Proteomics Analysis[Show abstract] [Hide abstract]
ABSTRACT: Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Several evidences suggest that MS can be considered a multi-factorial disease in which both genetics and environmental factors are involved. Among proposed candidates, growing results support the involvement of oxidative stress (OS) in MS pathology. The aim of this study was to investigate the role of OS in event of exacerbations in MS on serum of relapsing-remitting (RR-MS) patients, either in relapsing or remitting phase, with respect to serum from healthy subjects. We applied proteomics and redox proteomics approaches to identify differently expressed and oxidatively modified proteins in the low-abundant serum protein fraction. Among differently expressed proteins ceruloplasmin, antithrombin III, clusterin, apolipoprotein E, and complement C3, were up-regulated in MS patients compared with healthy controls. Further by redox proteomics, vitamin D-binding protein showed a progressive trend of oxidation from remission to relapse, respect with controls. Similarly, the increase of oxidation of apolipoprotein A-IV confirmed that levels of OS are elevated with the progression of the disease. Our findings support the involvement of OS in MS and suggest that dysfunction of target proteins occurs upon oxidative damage and correlates with the pathology.PLoS ONE 06/2013; 8(6):e65184. DOI:10.1371/journal.pone.0065184 · 3.23 Impact Factor
Article: Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's Disease neuropathology: Redox proteomics analysis of human brain.[Show abstract] [Hide abstract]
ABSTRACT: DS is the most frequent genetic cause of intellectual disability characterized by the anomalous presence of three copies of chromosome 21. One of the peculiar features of DS is the onset of Alzheimer's disease neuropathology after the age of 40 years characterized by deposition of senile plaques and neurofibrillary tangles. Growing studies demonstrated that increased oxidative damage, accumulation of unfolded/damaged protein aggregates and dysfunction of intracellular degradative system are key players in neurodegenerative processes. In this study, redox proteomics approach was used to analyze the frontal cortex from DS subjects under the age of 40 compared with age-matched controls, and proteins found to be increasingly carbonylated were identified. Interestingly, our results showed that oxidative damage targets specifically different components of the intracellular quality control system such as GRP78, UCH-L1, V0-ATPase, cathepsin D and GFAP that couples with decreased activity of the proteasome and autophagosome formation observed. We also reported a slight but consistent increase of Aß 1-42 SDS- and PBS-soluble form and tau phosphorylation in DS versus CTR. We suggest that disturbance in the proteostasis network could contribute to the accumulation of protein aggregates, such as amyloid deposits and NFTs, which occur very early in DS. It is likely that a sub-optimal functioning of degradative systems occur in DS neurons, which in turn provide the basis for further accumulation of toxic protein aggregates. The results of this study suggest that oxidation of protein members of the proteostatis network is an early event in DS and might contribute to neurodegenerative phenomena.Biochimica et Biophysica Acta 04/2013; 1832(8). DOI:10.1016/j.bbadis.2013.04.013 · 4.66 Impact Factor
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ABSTRACT: In this book, the authors present topical research in the study of the ecosystems, economic importance and environmental threats to the Mediterranean Sea. Topics discussed include the need for an economic and business oriented approach to ecosystem services in the Mediterranean Sea; marine pollution from shipwrecks at the bottom of the Mediterranean Sea; the effects of produced formation water (PFW) on the marine environment of the Mediterranean Sea; Secchi depth and water quality control; an environmental modeling plan for the construction and operation of a marine terminal for regasifying liquefied natural gas in the North Adriatic Sea; and a study of bioactive peptides from the venom of the Mediterranean cone snail conus ventricosus.Bioactive peptides from the venom of the Mediterranean cone snail Conus ventricosus., 01/2013: chapter Bioactive peptides from the venom of the Mediterranean cone snail Conus ventricosus.; Nova Science Publishers Inc.
Article: Calcium Binding Promotes Prion Protein Fragment 90–231 Conformational Change toward a Membrane Destabilizing and Cytotoxic Structure[Show abstract] [Hide abstract]
ABSTRACT: The pathological form of prion protein (PrPSc), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrPSc extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, although the contribution of this interaction to the molecular mechanism of neurodegeneration process is still controversial. We previously showed that the human PrP fragment 90–231 (hPrP90–231) increases ionic conductance across artificial lipid bilayer, in a calcium-dependent manner, producing an alteration similar to that observed for PrPSc. In the present study we demonstrate that hPrP90–231, pre-incubated with 10 mM Ca++ and then re-suspended in physiological external solution increases not only membrane conductance but neurotoxicity as well. Furthermore we show the existence of a direct link between these two effects as demonstrated by a highly statistically significant correlation in several experimental conditions. A similar correlation between increased membrane conductance and cell degeneration has been observed assaying hPrP90–231 bearing pathogenic mutations (D202N and E200K). We also report that Ca++ binding to hPrP90–231 induces a conformational change based on an alteration of secondary structure characterized by loss of alpha-helix content causing hydrophobic amino acid exposure and proteinase K resistance. These features, either acquired after controlled thermal denaturation or induced by D202N and E200K mutations were previously identified as responsible for hPrP90–231 cytotoxicity. Finally, by in silico structural analysis, we propose that Ca++ binding to hPrP90–231 modifies amino acid orientation, in the same way induced by E200K mutation, thus suggesting a pathway for the structural alterations responsible of PrP neurotoxicity.PLoS ONE 07/2012; 7(7). DOI:10.1371/journal.pone.0038314 · 3.23 Impact Factor
Dataset: journal.pone.0038314.suppl fig 2
Dataset: journal.pone.0038314.suppl fig 1
Article: HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody[Show abstract] [Hide abstract]
ABSTRACT: Failure in cytokinesis, the final step in cell division, by generating tetra- and polyploidization promotes chromosomal instability, a hallmark of cancer. Here we show that HIPK2, a kinase involved in cell fate decisions in development and response to stress, controls cytokinesis and prevents tetraploidization through its effects on histone H2B. HIPK2 binds and phosphorylates histone H2B at S14 (H2B-S14(P)), and the two proteins colocalize at the midbody. HIPK2 depletion by targeted gene disruption or RNA interference results in loss of H2B-S14(P) at the midbody, prevention of cell cleavage, and tetra- and polyploidization. In HIPK2 null cells, restoration of wild-type HIPK2 activity or expression of a phosphomimetic H2B-S14D derivative abolishes cytokinesis defects and rescues cell proliferation, showing that H2B-S14(P) is required for a faithful cytokinesis. Overall, our data uncover mechanisms of a critical HIPK2 function in cytokinesis and in the prevention of tetraploidization.Molecular cell 05/2012; 47(1):87-98. DOI:10.1016/j.molcel.2012.04.029 · 14.02 Impact Factor
Article: Oxidative Stress in HPV-Driven Viral Carcinogenesis: Redox Proteomics Analysis of HPV-16 Dysplastic and Neoplastic Tissues[Show abstract] [Hide abstract]
ABSTRACT: Genital infection by high risk Human Papillomavirus (HR-HPV), although recognized as the main etio-pathogenetic factor of cervical cancer, is not per se sufficient to induce tumour development. Oxidative stress (OS) represents an interesting and under-explored candidate as a promoting factor in HPV-initiated carcinogenesis. To gain insight into the role of OS in cervical cancer, HPV-16 positive tissues were collected from patients with invasive squamous cervical carcinoma, from patients with High Grade dysplastic HPV lesions and from patients with no clinical evidence of HPV lesions. After virological characterization, modulation of proteins involved in the redox status regulation was investigated. ERp57 and GST were sharply elevated in dysplastic and neoplastic tissues. TrxR2 peaked in dysplastic samples while iNOS was progressively reduced in dysplastic and neoplastic samples. By redox proteomic approach, five proteins were found to have increased levels of carbonyls in dysplastic samples respect to controls namely: cytokeratin 6, actin, cornulin, retinal dehydrogenase and GAPDH. In carcinoma samples the peptidyl-prolyl cis-trans isomerase A, ERp57, serpin B3, Annexin 2 and GAPDH were found less oxidized than in dysplastic tissues. HPV16 neoplastic progression seems associated with increased oxidant environment. In dysplastic tissues the oxidative modification of DNA and proteins involved in cell morphogenesis and terminal differentiation may provide the conditions for the neoplastic progression. Conversely cancer tissues seem to attain an improved control on oxidative damage as shown by the selective reduction of carbonyl adducts on key detoxifying/pro-survival proteins.PLoS ONE 03/2012; 7(3):e34366. DOI:10.1371/journal.pone.0034366 · 3.23 Impact Factor
Article: Importin- negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores[Show abstract] [Hide abstract]
ABSTRACT: Importin-β is the main vector for interphase nuclear protein import and plays roles after nuclear envelope breakdown. Here we show that importin-β regulates multiple aspects of mitosis via distinct domains that interact with different classes of proteins in human cells. The C-terminal region (which binds importin-α) inhibits mitotic spindle pole formation. The central region (harboring nucleoporin-binding sites) regulates microtubule dynamic functions and interaction with kinetochores. Importin-β interacts through this region with NUP358/RANBP2, which in turn binds SUMO-conjugated RANGAP1 in nuclear pores. We show that this interaction continues after nuclear pore disassembly. Overexpression of importin-β, or of the nucleoporin-binding region, inhibited RANGAP1 recruitment to mitotic kinetochores, an event that is known to require microtubule attachment and the exportin CRM1. Co-expressing either importin-β-interacting RANBP2 fragments, or CRM1, restored RANGAP1 to kinetochores and rescued importin-β-dependent mitotic dynamic defects. These results reveal previously unrecognized importin-β functions at kinetochores exerted via RANBP2 and opposed by CRM1.The Journal of Cell Biology 02/2012; 196(4):435-50. DOI:10.1083/jcb.201109104 · 9.83 Impact Factor
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ABSTRACT: Highly stable natural scaffolds which tolerate multiple amino acid substitutions represent the ideal starting point for the application of rational redesign strategies to develop new catalysts of potential biomedical and biotechnological interest. The knottins family of disulphide-constrained peptides display the desired characteristics, being highly stable and characterized by hypervariability of the inter-cysteine loops. The potential of knottins as scaffolds for the design of novel copper-based biocatalysts has been tested by engineering a metal binding site on two different variants of an ω-conotoxin, a neurotoxic peptide belonging to the knottins family. The binding site has been designed by computational modelling and the redesigned peptides have been synthesized and characterized by optical, fluorescence, electron spin resonance and nuclear magnetic resonance spectroscopy. The novel peptides, named Cupricyclin-1 and -2, bind one Cu(2+) ion per molecule with nanomolar affinity. Cupricyclins display redox activity and catalyze the dismutation of superoxide anions with an activity comparable to that of non-peptidic superoxide dismutase mimics. We thus propose knottins as a novel scaffold for the design of catalytically-active mini metalloproteins.PLoS ONE 02/2012; 7(2):e30739. DOI:10.1371/journal.pone.0030739 · 3.23 Impact Factor
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ABSTRACT: Microglia-mediated inflammation in the central nervous system is a hallmark of the pathogenesis of several neurodegenerative diseases including Alzheimer's disease. Microglial cells activation follows the deposition of amyloid β fibrils and it is generally considered a triggering factor in the early steps of the onset of Alzheimer's disease. Although the initial engagement of microglia seems to play a neuroprotective role, many lines of evidence indicate that a persistent activation with the production of proinflammatory molecules contributes to dismantle neuronal activity and to induce neuronal loss occurring in neurodegenerative diseases. To date, limited proteomic data are available on activated microglial cells in response to extracellular amyloidogenic peptides. In this study, murine microglial cells have been employed to investigate the effects of amyloid β peptides in triggering microglial activation. The response was monitored at the proteome level through a two-dimensional gel electrophoresis-based approach. Results show only a limited number of differentially expressed proteins, among these a more acidic species of the cytosolic actin, and the 14-3-3ε protein, found significantly upregulated in Aβ-activated cells. 14-3-3ε belongs to a regulatory protein family involved in important cellular processes, including those leading to neurodegenerative diseases, and thus its increased expression suggests a role of this protein in tuning microglia activation.Proteomics 01/2012; 12(1):124-34. DOI:10.1002/pmic.201100113 · 3.81 Impact Factor
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ABSTRACT: Post-translational modifications of Notch3 and their functional role with respect to Notch3 overexpression in T-cell leukemia are still poorly understood. We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired by HDAC inhibitors (HDACi) that favor hyperacetylation. By using HDACi and a non-acetylatable Notch3 mutant carrying K/R(1692-1731) mutations in the intracellular domain, we show that Notch3 acetylation primes ubiquitination and proteasomal-mediated degradation of the protein. As a consequence, Notch3 protein expression and its transcriptional activity are decreased both in vitro and in vivo in Notch3 transgenic (tg) mice, thus impairing downstream signaling upon target genes. Consistently, Notch3-induced T-cell proliferation is inhibited by HDACi, whereas it is enhanced by the non-acetylatable Notch3-K/R(1692-1731) mutant. Finally, HDACi-induced Notch3 hyperacetylation prevents in vivo growth of T-cell leukemia/lymphoma in Notch3 tg mice. Together, our findings suggest a novel level of Notch signaling control in which Notch3 acetylation/deacetylation process represents a key regulatory switch, thus representing a suitable druggable target for Notch3-sustained T-cell acute lymphoblastic leukemia therapy.Oncogene 11/2011; 31(33):3807-17. DOI:10.1038/onc.2011.533 · 8.46 Impact Factor
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ABSTRACT: Molecular mechanisms underlying abdominal aneurysm (AAA) formation and rupture are not well understood. Early detection and repair of AAA may reduce the high mortality rates associated with rupture. Serum proteomics allows the detection of alterations in the expression of proteins, guiding further studies on these target molecules as potential markers. Analysis of proteomic profile of asymptomatic patients with AAA allows the identification of reliable predictors or markers of disease presence or progression. A proteomics approach based on two-dimensional electrophoresis and mass spectrometry was used to compare serum proteomic profiles of patients with AAA who are candidates for surgical repair compared with healthy controls. We analyzed in parallel the proteomic profile of subjects with cardiac heart failure to discriminate these two pathologies, which show similar pattern of systemic inflammation process. We identified in AAA subjects four serum proteins that show altered expression profile and that could be specifically linked to AAA pathology. We discuss the role of our identified proteins with their possible implications in disease outcome. This approach could provide an initial screening tool that may drive the basis for further research in the field of cardiovascular diseases. These results need to be validated in larger studies to find potential markers of AAA presence or progression to use in clinical settings. A proteomics approach was used to compare serum proteomic profiles of patients with abdominal aortic aneurysm who are candidates for surgical repair compared with healthy controls. Four serum proteins showed altered expression profile that could be correlated with the pathology. This approach could provide an initial screening tool that may drive the basis for further research in the field of cardiovascular diseases.Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology 11/2011; 21(4):283-90. DOI:10.1016/j.carpath.2011.09.008 · 2.00 Impact Factor
Top Journals
Sapienza University of Rome
Roma, Latium, Italy
- • Department of Biochemical Sciences "Alessandro Rossi Fanelli
- • Department of Surgical Sciences
University of Rome Tor Vergata
Roma, Latium, Italy
- Dipartimento di Biologia
Università degli Studi di Perugia
Perugia, Umbria, Italy
- Department of Clinical and Experimental Medicine
Università Degli Studi Roma Tre
Roma, Latium, Italy
- Department of Biology
University of Oxford
Oxford, England, United Kingdom
- Laboratory of Molecular Biophysics
National Institute of Geophysics and VolcanologyRoma, Latium, Italy
The American University of RomeRoma, Latium, Italy
National Research Council
Roma, Latium, Italy
- Institute of Biomolecular Chemistry ICB


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about Todd FlowerdayA Roman Catholic lay person, married (since 1996), with one adopted child (since 2001). I serve a parish in music ministry.
about John Donaghy
John is a lay missionary since 2007 with a parish in western Honduras. Before that he served in campus ministry and social justice ministry in Iowa. His ministry blog is http://hermanojuancito.blogspot.com
He also blogs reflections on the lectionary and saints/heroes/events of the date at http://walktheway.wordpress.com
He'll be a long-term contributor here analyzing the Latin American bishops' document from their 2007 Aparecida Conference.
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Tag Archives: Elizabeth Johnson
Theologian Pokes At Bishops
I haven't been following the news bits on the LCWR assembly in Nashville. But I did notice that Professor Elizabeth Johnson's two significant pokes at the US bishops. In one instance, reading comprehension isn't even an issue. The guys simply … Continue reading
Posted in bishops, sex abuse, women religious Tagged cover-up scandal, Elizabeth Johnson, LCWR 2 Comments

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Past Exhibitions
Vision Project Gallery presents: MATTERINGS»
August 2, 2010- January 2, 2011;
Artist Rose B. Simpson's work in Matterings, curated by Michelle McGeough, inaugurates the MoCNA's newly formed Vision Project Gallery, a new space dedicated to enhance the Vision Project's goal of establishing an indigenous arts discourse that reflects the vibrancy and potency of the field at its most current level of activity.
August 2, 2010 – January 2, 2011;
The site specific new work Apaches and Angels by Douglas Miles and his crew Lynette Haozous, Rebekah Miles and Razelle Benally connect the universality of skateboard subculture to today's Native youth and beyond.
SPLASH: IAIA 2010 BFA Exhibition »
March 5 – May 13, 2010;
This exhibit highlights the work of students receiving their bachelor of fine arts degrees from IAIA.
Scout's Honour »
October 10, 2009 – January 31, 2010;
In August 2006, artists Michael Belmore and Frank Shebageget set out on an expedition to explore the social, environmental and cultural landscape of Northern Ontario.
BADLAND: Rebecca Belmore, Lori Blondeau, Bonnie Devine, and Erica Lord »
June 26, 2009 – January 31, 2010;
The exhibit explores the ever-changing nature of land, bringing attention to issues of sovereignty, destruction and culture as those relate back to the land and its inhabitants.
The Drawings and Paintings of Daphne Odjig: A Retrospective»
June 26 - September 20, 2009;
Featuring Odjig's history and legend paintings, erotica, abstractions and landscapes, together these pieces communicate the breadth of Odjig's engagement with her personal, political and cultural history.


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In This Section
Journal Forum
Synthetic Reverberator - January 1960
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Multichannel Sound Reproduction Quality Improves with Angular Separation of Direct and Reflected Sounds - June 2015
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Clean Audio for TV broadcast: An Object-Based Approach for Hearing-Impaired Viewers - April 2015
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AES E-Library
Functional Protection of High-Power Amplifiers
A set of criteria is developed for optimizing the amplifier protection system with respect to both the needs of the devices employed and the load to be driven. A practical dynamically confining system is described with its application to two high quality amplifiers of different power levels.
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1996 Toyota Tercel in Lexington, KY
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1996 Toyota Tercel 4 Dr DX Sedan Review
|by Davis
"Get it if you just want a really economic car"
The car is all about economics. This car is not made for performance, its pretty slow actually, but the cost of maintenance is next to zero. This doesn't have good handling or braking, but its ok. The materials made for this car are top notch, and the gas mileage its one of the bests around.
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1997 Toyota Tercel 2 Dr CE Coupe Used Cars in Louisville, KY 40214
Price: $4,295
Mileage: 149,665
Location: Louisville, KY 40214
Certified Pre-Owned: No Transmission: Automatic Color: Red Description: Used 1997 Toyota Tercel 2 Dr CE Coupe for sale - $4,295, 149,665 miles
Avg. Dealer Rating: (1 review) "When we arrived at this car lot at 2 in the afternoon on a Tuesday, no one was present. The vehicle we were interested in had been damaged and poorly repaired. Just as we were about to leave after waiting 15 minutes to make a phone call, a young man appeared from across the street. As he neared us, he called out, "Can I help you?" I told him we'd come to look at the particular car, but I didn't want it. He said, "Okay," and kept walking."
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text:
Oprah Winfrey's "The Life You Want Weekend" tour this fall includes a stop in Washington and available tickets for the show are as much as $599.
They're also a little as $99, although according to the online ticket ordering seat map, there aren't many seats available at that price.
Most seats available fall in the $199, $299 and $599 category, according to the current map.
A VIP section that includes a meet-and-greet with Oprah also lists tickets for as much as $999, though it appears none are currently available.
What's Oprah's "The Life You Want" tour?
"An unprecedented arena tour that will engage, encourage and empower," according to her website. "Not only will you see the possibilities of a new life — the life you want — you'll leave transformed and ready to take charge and make it happen."
Oprah's inspirational road show stops at Verizon Center the weekend of Sept. 19 and Sept. 20. The tour kicks off in Atlanta Sept. 5 and finishes in San Jose Nov. 14.
Auburn Hills, Mich., Newark, Houston, Miami and Seattle are also on Oprah's tour schedule.
The hurricane missed the region, but heavy rain is still expected.


text:
Season Passes
2015-2016 Season Passes may be purchased online or at Mount Pakenham office.
If you ski or ride once a week or more, then a Season Pass is for you. Enjoy UNLIMITED skiing or riding plus ...
- Go straight to the lifts on arrival- no need to get a day ticket!
- "Bring a Friend for Free" coupons usable Friday days or nights or Saturday nights and some Anytime Anyday "Bring a Friend" coupons. Coupons issued only when paying full price for pass (hot rate or regular rate).
- Complimentary tubing from 4pm-5pm for season passholders.
- Discounts in our retail store - 10% off regular prices in retail shop (item must be a minimum of $15 to receive discount)
- Coupon for a Free Snowshoe Adventure.
- Discounts on ski and snowboard tuning - 15% discount on tuning skis/boards.
- Two free tubing day passes.
- Coupon for $5 off a private lesson.
- Two coupons for a delicious 2 for 1 Hot Chocolate. Season pass coupons issued only when paying full price for pass (hot rate or regular rate).
- Discounted lift rates at many Ontario & Quebec ski resorts:
Bromont-25% off; Calabogie Peaks-50% off; Camp Fortune-25% off; Mont Blanc-25% off; Mont Cascades-50% off; Mont Habitant-25% off; Mont Ste.Marie-25% off; Mont Sutton-50% off w/day & 25% off w/end; Owls Head -approx 35% off - call us for details; Snow Valley-2 for 1 tickets; Vorlage-25% off.
Sport Retailer discounts: Use your Mount Pakenham Season Pass to get super deals at these retailers:
- Kunstadt Sports: kunstadt.com; 462 Hazeldean Rd, Kanata - Tel 831-2059 - 12% off
- Sport X: sportx.ca; 11 Chambers St, Smith Falls - Tel 284-1632 - 20% off
- Dinardo's Skis & Wheels: dinardoskis.com; 44 Northside Rd, Bells Corners - Tel 596-0007 - 20% off ski tuning and NO TAX on regular priced items.
- Bushtukah Outdoor Gear: bushtukah.com; 203 Richmond Rd, Ottawa - Tel 792-1170 or 5607 Hazeldean Rd. Kanata - Tel 613-831-3604 - 10% off
- Fresh Air Experience: freshairexp.ca; 1291 Wellington St West, Ottawa - Tel 729 3002 - 10% off in-stock Cross Country related products
- Surf Side: surfsideonline.com; 2222 Carling Ave, Ottawa - Tel 726 7873 - 30% off tune ups and no tax on all current year's equipment
- Sun Mountain Sports: sunmountainsports.ca; 203 Sanders St, Kemptville - Tel 258-0533 - 10% off
- Top of The World: topoftheworld.com; 158 Rideau, Ottawa - Tel 237-4797 - 15% off
Need we say more?
(Pssssst! Receive an additional 10% off your season pass* when booking a multi-day Snow School program!)
*10% Season Pass discount will be applied after completion of your online reservation. Final payment will be processed by us with discounted rate.
- Program: One season's Lift and Trail pass for skiing or riding with lots of added extras.
- Available: Purchase anytime but the earlier you purchase, the more you save! Please add harmonized sales tax.
- Equipment: Bring your own or rent ours
- Fine Print: Family consists of a married couple or at least 3 paying members of: Father and/or Mother and their children under the age of 21 who are living together at home. Family Max price is based on a family of 4. An additional $25/family member will be charged to families that exceed the family maximum.
Ages as of December 1/15. Proof of ID may be required.
Night Pass includes Tuesday to Saturday nights. The Almost Anytime Pass includes 5 day Monday to Friday and 5 nights Tuesday to Saturday every week except December 25 to January 3 daytime.
Season passholders must get picture taken at hill and fill out waiver form before pass is issued.
- Ability Levels:Beginner - Expert
|Program Pricing
|Seniors (over 70) / Children (under 6) Regular Price $25, Hot Rate until Oct 9/2015 $15 +HST
|Adult Season Pass(18-69) Regular Price $389+HST- Hot Rate until Oct 9 / 2015 $339 + HST
|Youth Season Pass (13-17) Regular Price $315+HST- Hot Rate until Oct 9 / 2015
|Child Season Pass (6-12) Regular Price $285+HST. Hot Rate until Oct 9 / 2015
|Almost Anytime Season Pass Regular Price $245+HST- Hot Rate until Oct 9 / 2015
|Night Skiing Season Pass Regular Price $199+HST- Hot Rate until Oct 9 / 2015
|Cross Country Season Pass Regular Price $79+HST- Hot Rate until Oct 9 / 2015
|FAMILY-1st Adult (18 - 69) Member Pass Regular Price $389+HST- Hot Rate until Oct 9 / 2015
|FAMILY-2nd Adult (18 - 69) Member Pass Regular Price $329+HST, Hot Rate until Oct 9 / 2015
|FAMILY-Additional Youth (13 -17) Season Pass Regular Price $285+HST- Hot Rate until Oct 9 / 2015
|FAMILY-Additional Child (6-12)Season Pass Regular Price $245+HST- Hot Rate until Oct 9 / 2015
|Family Max 5+ members Regular Price add $25+HST, Hot Rate until Oct 9 / 2015 $15 + HST
|Family Max Regular Price $1097+HST Hot Rate until Oct 9 / 2015 $997 +HST
|Family Max Night Passes(4 family members)Regular Price $699+HST, Hot Rate until Oct 9 / 2015 $639 + HST
|Program Options
|Lockers keep your equipment warm, dry, secure and makes skiing easy (Rental).
|Season Regular Family Sized Locker (12 in x 22 in) Regular price $105, Hot Rate until Oct 9 / 2015 $99 + HST
|SOLD OUT - Season Large Family Sized Locker(15 inches x 24 inches) -Regular price $115


text:
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Valid for tea service Saturday and Sunday from 2-4:30 p.m. only. Reservations required; subject to availability. Limit one voucher per table. Not valid on holidays or holiday weekends (call merchant for specific date restrictions). Limit two purchases per person; may buy two additional as gifts. If limit is exceeded, voucher subject to forfeiture. Tax, if applicable, and gratuity are not included. Please tip on the full value; 18-20% is customary for good service.See all terms
M – F, 9am – 9pm ET
|Enjoyed Most
|Other Comments
Being by the water, the helpful staff, and the picnic atmosphere of the lobster bake!
|Aug 5, 2015 SUSAN FL, United States
Outside seating
|Jul 30, 2015 Christopher Massachusetts, United States
Wonderful meal and service. Great atmosphere.
|May 15, 2015 Paul MA, United States
The decor is very pretty.
I was told that, although the 2 vouchers I purchased had expired, the hotel would honor the special deal I purchased (Tea for Two - purchased 2 vouchers for $49. each). But instead, we were charged the usual price - $39. per person - times 4 people = $156. And then my vouchers were deducted, leaving us with a balance of $60.+ instead of Zero :-/ It wouldn't have been so bad if the food were better and more plentiful.
|Feb 9, 2015 Grace NH, United States
The food and staff were wonderful! And it was such a beautiful venue. I imagine it's even nicer during warmer weather when you can sit outside by the water.
|Feb 7, 2015 Katie
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text:
As a general surgeon in Mobile, Dr. Donna Dyess performs surgical procedures to treat conditions affecting the abdomen and related structures, like hernias or tumors.
Learn More
We invite you to write a review about your experience with Dr. Dyess.
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text:
Dear Student:
Welcome to Santa Barbara City College and Disabled Student Programs and Services (DSPS).
We are committed to creating an accessible learning community where individuals with disabilities have an equal opportunity to pursue their educational goals. We strive to empower students, foster independence, and promote achievement through self-advocacy.
DSPS is responsible for arranging reasonable accommodations for all qualified students with a documented disability. The process for obtaining reasonable accommodations is an interactive one that begins with the student's disclosure of his/her disability.
We look forward to supporting your success!
Jana Garnett, Director
How to Apply for DSPS services:
Step 1:
Obtain detailed documentation of your disability from a licensed professional OR from your high school.
Step 2:
Make an appointment to meet with a DSPS Specialist to review your documentation and discuss reasonable accommodations.
Please call us at (805) 730-4164 to schedule a meeting.
Step 3:
Bring your disability documentation to your DSPS appointment.
We are located in Room 160 of the Student Services building.
To request the release of DSPS disability documents to another college please contact our office 805.965-0581 ext. 2364


text:
POLOKWANE Paraguay will have to improve their passing and start to convert chances if they want to make it through to the World Cup quarter-finals, coach Gerardo Martino says.
The Argentine-born coach was not pleased with Paraguay's performance in a disappointing 0-0 draw against New Zealand that was enough to take them into the last 16.
They now face Japan in the second round on Tuesday.
"We were not very mobile and we were quite inaccurate," he told reporters after the match. "We had a lot of problems in an area where we didn't expect, and that was in attack."
They were solid in defence though, conceding only one goal in three matches against Italy in the first game.
"I think Paraguay had an excellent aspect to the defensive part in the three matches, we were very good defensively," Martino said.
Paraguay, ranked 31st in the world by FIFA, topped Group F but managed just one win against Slovakia and scored only three goals despite a trio of top-class strikers in Roque Santa Cruz, Lucas Barrios and Nelson Valdez.
All three were on the field at the end of the New Zealand game and yet they failed to convert a number of opportunities.
Martino said the side would have to raise their game to get through to the quarter-finals.
Last 16 opponents Japan overpowered Denmark on Thursday, scoring three goals and have been transformed from the side that lost a series of friendlies leading into the tournament.
Santa Cruz said the players were not happy with their showing against New Zealand but the important thing was that they had made it through the group.
"Maybe today we had the feeling that we weren't altogether happy with ourselves .. we had opportunities and we should have put them away," he said.
"I think we were not as patient as we should have been."
Santa Cruz said a quarter-final berth would be a job well done for Paraguay but added that once they were there, anything was possible.
"We would have considered it a very good World Cup if we were to get to the quarter-finals, that for us is good enough and after that it is a dream," he said.
"But we have the wherewithal to make it further."
(Editing by Michael Holden)
Trending On Reuters
Platini preoccupied as grand plan comes to fruition
With an almost unbelievably cruel and ironic sense of timing, Michel Platini's grand plan to open up the European championship finals to more countries than ever before is reaching its climax just as he faces a possible suspension from football. Full Article
Android App for India
Download the Reuters app from Google Play and select the India edition for breaking news, analysis and market updates. | Learn More


text:
There are reports of shots being fired in Big Bear, the area where Christopher Dorner, a former LAPD officer suspected of killing a couple and a Riverside police officer, disappeared after fleeing authorities.
|comments powered by Disqus
(Stephan Rabold/Showtime)
'Homeland,' 'Arrow,' 'The Flash' kick off new seasons
'The Good Wife' opener is among the highlights of a busy TV week.
(Alan Silfen/Sony via AP)
Will Smith making music again
'Suicide Squad' actor raps on Bomba Estereo's "Fiesta" remix.


text:
Why did you choose this product?
Cuisinart must be the new word for "it works". We've had this pot for quite a while now and it still works as efficiently as it did on Day 1. The carafe keeps coffee hot for hours so I don't feel like I'm having day old coffee an hour after the first cup is brewed. Good product. Good value....
ITEM#: 13011637Wake up to the aroma of a fresh brew with this 10-cup thermal coffeemaker. With such a large capacity, you'll have enough for overnight guests, but this coffeemaker also has a 1-4 cup setting. The thermal carafe features double-wall insulation, so contents are kept at the right temperature for longer. This fully automatic coffeemaker is also self cleaning, shuts off automatically when not in use, and features a clock display and light indicator so you always know when it's time to enjoy your cup of coffee.
- Black color option
- Fully automatic coffeemaker
- 24-hour programmable
- 10-cup carafe with ergonomic handle, dripless spout and knuckle guard
- Double-wall insulated thermal carafe
- 1- to 4-cup setting
- Brew pause
- Self cleaning
- 60-second reset
- Gold Tone coffee filter and charcoal water filter
- Measures approximately 8 inches wide x 9 inches deep x 13 inches high
|Cord Length
|More than 1 ft.
|Cups Per Brew
|2-5 Cups 6-10 Cups
|Product Features
|Auto Shut Off Clock Display Ready Indicator Light
|400-600 Watts
|3 year Limited Manufacturer
|Model Number
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Customer Reviews
- Disclosures & Guidelines
- Filter By:
- Most Helpful
- Most Recent
Steve in Texas
Cuisinart must be the new word for "it works". We've had this pot for quite a while now and it still works as efficiently as it did on Day 1. The carafe keeps coffee hot for hours so I don't feel like I'm having day old coffee an hour after the first cup is brewed. Good product. Good value.Read More
overall coffee maker is ok. the twisting lid has no clear open spot so pouring is not the best.Read More
Not so great
It is temperamental , doesn't keep the coffee warm, and wears out too quickly- I have gone thru two and switched to another brandRead More
Nice product
This coffee maker replaced another Cuisinart which was at least 12 years old. Hopefully this one will perform as wellRead More
Pretty Darn Good
This is the second one I have purchased. The first lasted a decade, and functioned very well with regular changes of the little pillowy filters. These, however, are not cheap. My main dissatisfaction with the prior pot is that the metal disc on the bottom discolored my formica counter due to rust. I hope to keep the new one dry enough to avoid this happening again.Read More
I was lucky enough to receive 2 coffee makers for Christmas and I ended up choosing to keep this one. I was leary of having a caraffe, but after reading through I realized that it will not have that burnt on effect that others may have as it turns off completely when the coffee is done brewing and the insulated thermal caraffe keeps it hot for hours (tested and true). The coffee maker is very appealing to the eye and it also comes with a permanent filter so that you do not need to use/buy the paper ones. It is very easy to program for next day use. I highly recommend it!Read More
Great coffeemaker!
I enjoy having a filter built in, the 5 beeps to let me know that the coffee is done and it automatically shuts off. I was amazed at how long the carafe keeps the coffee hot. Best coffemaker I have owned.Read More
thermal is the way to go
the thermal pot is the way to go. we bought this to replace the prior one we had which lasted 10 years. if this dies in a year i'll be sure to post.Read More
Nice coffee maker
We enjoy very much the coffee it makes, especially with the metallic filter. The only snag is the lid. We can't open it easily (especially a lady with "nails"). It is extremely tight. Would have given it a four star review otherwise.Read More
A little disappointed
I am a little disappointed with this Cuisinart Thermal Coffeemaker. The design of the carafe makes it hard to pour all the water into the machine. The coffee stays warm but not as hot as it did with the glass carafe on my old model. The knob on the older models had a better design and turned more easily than this model. I would not switch from Cuisinart but this model leaves me disappointed.Read More
Questions & Answers
We had a similar Cuisinart Thermal Coffee Maker which is having problems. Liked the old one, so buying the updated new one.
Brand name
We choose this coffee maker because of the thermal caraff.
I have one just like this but the base has gotten corroded.
Size of coffeemaker, I needed something not as tall as some out there. Also programmable and has brew pause.
ii like it
Recommended by a coffee drinker friend!
Previoous experience.
Compact and automatically turns off while keeping coffee hot.
What is the charcoal filter and it's purpose?
Hello barlo711, the charcoal filter is a water filter for this coffeemaker that is found inside the machine. Thank you for shopping with us!
Do you have to replace the goldtone coffee filter and charcoal water filter? Do you use paper filters at all?
Hello ffud, The goldtone coffee filter is a permanent filter, you should replace the charcoal filter every 60 days or 60 uses or more if you have hard water, and the filter basket holds a # 4 paper filter or the permanent filter. Thank you for shopping with us.
Is this product for in-home use only?
Thank you for your question. This coffee pot is designed to be used in home. Please let me know if we can do anything else for you.
Shopping Tips & Inspiration
Best Coffee Maker Features
Best Coffee Maker Features from Overstock.com. This guide will give you all the information you need to find and buy the right coffee maker for you.
How to Be Your Own Barista
How to Be Your Own Barista from Overstock.com. Our guides provide customers with information about brewing your own coffee at home and advice about our many brand-name products.
Drip Coffee Makers vs French Press Coffee Makers
Drip Coffee Makers vs. French Press Coffee Makers from Overstock.com. Our guides provide customers with information about drip and French press coffee makers and advice about our many brand-name products.
Coffee Maker Buying Guide
Coffee Maker Buying Guide from Overstock.com. This guide outlines the different types of coffee and espresso machines, so you can buy the right one for you.
How to Clean Glass Coffee Pots
How to Clean Glass Coffee Pots from Overstock.com. Our guides provide customers with information about how to clean glass coffee pots and advice about our many brand-name products.
Types of Coffee Brewers Fact Sheet
Types of Coffee Brewers Fact Sheet from Overstock.com. Our guides provide customers with facts about the different types of coffee brewers and advice about our many brand-name products.
How to Brew the Perfect Pot of Coffee
How to Brew the Perfect Pot of Coffee from Overstock.com. There's no reason to spend your time and money at the coffee shop every morning when you can brew the perfect pot of coffee at home for a fraction of the cost.
Kitchen Appliance Wish List for Newlyweds
Kitchen Appliance Wish List for Newlyweds from Overstock.com. This guide will help you create your own registry or choose the best appliance to give the new couple.
Top Appliances for Christmas
Top Appliances for Christmas 2014 from Overstock.com. Surprise that special someone -- or yourself! -- this Christmas with one of these top appliances.
Top 5 Kitchen Appliances You Don't Have
Top 5 Kitchen Appliances You Don't Have from Overstock.com. Our guides provide customers with information about top kitchen appliances and advice about our many brand-name products.
Urban Farmhouse Kitchen
Evoke a sense of warmth and comfort combined with decorative elements in this jesGORDON farmhouse kitchen.
The Kitchen Collection
Even the best cooks need the right kitchen tools. Whether you're a pro baker or a wannabe sous chef, having the right equipment can make or break your dish. Be prepared to whip up a feast with these colorful kitchen upgrades.
A Cinco de Mayo Fiesta
Turn your home into a colorful Mexican casita with bright bowls and plates, a few desert plants, and Southwestern area rugs. Then throw a Cinco de Mayo celebration with friends and family. We'll bring the appetizers - or at least the recipes.
Gifts for the Gourmet Mom
There's nothing quite like Mom's cooking. Your favorite chef may have some seriously outdated supplies, though. Brighten her kitchen with a fresh batch of cookware. Your taste buds will thank you.
Wedding Bells At Pride Parade
"It's not just gay marriage, to us it is marriage. Whether it's gay, straight, lesbian, or anything in between, every person should have the right to marry whomever they want and to be happy."
Shipping & Returns
Standard Return Policy:
Items must be returned in new or unused condition and contain all original materials included with the shipment. More Details
FINAL SALE EXCLUSION: Items marked as FINAL SALE are not returnable unless the problem you experience is the result of our error.
Shipping Information:
Our standard shipping method is ground shipping. We also offer expedited shipping for most items. Your final
shipping cost and estimated delivery timeframe will be available at checkout.
Standard shipping details
Expedited shipping details
For your protection, all orders are screened for security purposes. If your order is selected for review, our Loss Prevention Team may contact you by phone or email. There may be a two business day delay to process your order.
** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.


text:
Orbot: Tor Anonymity for Android Mobile Phones
The Tor project provides an Orbot package for Android mobile phones so that they too can access the Tor anonymity network.
With Orbot from Tor on Android 1.x and 2.x devices, you can protect your mobile phone from traffic and location analysis, whether it be Web surfing, emails or instant messages. For the latter, Tor developers recommend the Beem IM client in the Android Market. For Web surfing, the HTTP proxy settings are on the project webpage. For Android 2.x devices, you must acquire root privileges to proxy IP traffic.
Orbot is not available in the Android Market and needs to be downloaded from the project webpage. The software is under BSD licensing.
Issue 180/2015
Buy this issue as a PDF
Bugzilla Bug
Bug database has a bug of its own that could allow an intruder to create an unauthorized account.
US Launches New Strategy for Broadband Access
Report focuses federal resources on achieving universal Internet access.
RC4 Finally Gets the Fork
Leading browser makers say "no" to porous encryption algorithm
IBM Says TOR Network a Vehicle for Ransomware
Report from the X-Force group says attackers are using TOR to hide their crimes
Mozilla Announces new Firefox API
Future Firefox extensions will be compatible with Chrome.
Weird Security Flaw Affected Intel Chips for 16 Years
Better read this if you bought your computer before 2011
OpenSSH 7.0 Secure Shell Arrives
Users should upgrade to the new version as soon as possible
Qemu Flaw Lets the Guest Escape
Xen project announces a privilege escalation problem for Qemu host systems
Android Bug Threatens Millions of Users
Attackers can compromise an Android phone just by sending a text message
Lenovo and Canonical Announce Laptop Deal
PC vendor will pre-install Ubuntu on portables in India.


text: Medical Students, We're Only Looking for the Best September 30, 2015 09:30 am — AAFP President Wanda Filer, M.D., M.B.A., has a message for medical students. Family medicine is the specialty for physicians willing to and capable of learning more than one body system, providing comprehensive care and being an advocate. All others need not apply. Full Story »


text:
A brilliantly vibrant and unforgettable logo design that jumps right out at you! The use if colour here is fascinating, the lack of restraint helping the design to make a great impact.Posted in Branding → Logo
A basic but sharp logo design that uses the company letter as the focal point. The use of lime green works to add interest to an otherwise relatively straightforward design. The font is interesting, and benefits from the reflection effect, but is still very readable.Posted in Branding → Logo


text:
It's hard not to feel sorry for the residents of Memphis, Tennessee. Depending on which source you consult, its violent crime rate hovers between three and four times the national average, and various publications describe it...more
- Disparate Impact Hiring & Firing Job Promotions Law Enforcement Title VII
Class action lawsuits alleging disability discrimination are uncommon, and those involving disparate impact claims are less common still. This is due, in part, to the fact that unlike other types of discrimination claims, a...more
- Class Action Disability Discrimination Discrimination Disparate Impact Hiring & Firing Obesity
On May 30, 2013, the Sixth Circuit issued its decision in Davis v. Cintas Corporation, Case No. 10-1662 (6th Cir. May 30, 2013), in which it upheld a district court's refusal to certify a disparate impact Title VII case, but...more
- Class Action Commonality Discrimination Disparate Impact Dukes v Wal-Mart EEOC Hiring & Firing Predominance Requirement Rule 23(b)(2) Sex Discrimination Summary Judgment Title VII
Hilti, Inc. sells power equipment for use in construction sites. A quick trip through its website reveals tools most people wouldn't have in their home workshops, such as 1100-watt demolition hammers, gas-powered fasteners,...more
- Class Action Class Certification Disparate Impact EEOC Sex Discrimination Summary Judgment Title VII
Class Action
Class Certification
Wage and Hour
Employer Liability Issues
Collective Actions
Hiring & Firing
Arbitration Agreements
Attorney's Fees
Dukes v Wal-Mart
Putative Class Actions
Rest and Meal Break
Title VII
Unpaid Overtime
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text:
Measuring your content: Converting audiences into bookings [ATWS slide deck & resources]
Re-cap the details of our ATWS session on content strategy with the following deck. Links to further reading and additional resources are also provided below. Links & further reading Slide #7: Google's customer journey tool / Mapping the travel marketing funnel Slide #10: See the ebook in action Slide #11: The biggest mistake in content marketing (and… continue reading


text:
3 Things
The 3 things I'm loving right at this very minute (lots more to see when you follow the links):
1. Art by Adrian Johnson
2. Jewelry by Nectar Jewelry
3. Art by Otoshimoto
The 3 things I'm loving right at this very minute (lots more to see when you follow the links):
1. Art by Adrian Johnson
2. Jewelry by Nectar Jewelry
3. Art by Otoshimoto
I'm excited about these new photos that I took yesterday. I was pushing myself to do something other than florals this time, and this is what I came up with. As always, you can visit my flickr album for more.
Thanks again for all of your encouragement everyone… you are all so inspiring to me!
Loving these colors still. So inspirational!
-Lacquer Dove Necklace and Rosebud Ring both from Forever 21
-Color in the bedroom photo from Domino Magazine online
-Wrapped and Ready – photo from flickr user prickly pear bloom
-Bird Shirt Cards by Art School Girl at Greer Chicago
Photo by Mav | Port2Port
Yesterday I received the loveliest get well card in the mail (thank you Holly), and it reminded me of how incredibly wonderful, but so sadly forgotten the art of letter writing is. When was the last time you found anything in your mailbox besides junk mailers and magazines? My Mom always said, "You have to write letters to get letters" and I think it's about time I listened to her!
If your looking for someplace to start, pay a visit to the beautiful shop Red Stamp, and you'll soon be on your way to a mailbox full of delights! xox Ez
{all images – Red Stamp}
I'm not the first one to spot the inspirational home and work of Cindy – flickr member Quaint Handmade (you can read an interview about her on Modish blog), but I just had to show you a few photos of her lovely space and creative handmade goods.
Doesn't Cindy's home remind you of multi-dimentional inspiration board? There are so many layers, but each piece plays beautifully off of the the next, and the effect is just wonderful!
See more of Cindy's Inspired Space and lovely handcrafted treasures… and be sure to visit her blog as well.
UPDATE: The beautiful wall pocket/pin board here was created by Cindy, but you can find similar boards from Sally Shim {Shim + Sons} – you may need to contact her with interest, or you can try your hand at making one with this tutorial.


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Two piece dressing is a must this season. Master the trend with our perfect pairings of crop tops, sleek pencil skirts and short suits. When it comes to style, you've met your match.


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Sweet Dreams For Kids
Rating: 4.87 stars 75 reviews
Issues: Health
Location: St Louis Park MN 55416 USA
Results: We have donated over 10,000 pairs of new pajamas to many Children's hospitals in Minnesota and nationwide
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In June we arrived by ambulance to the ER because my daughter was having a hard time breathing. The ER admitted us to the hospital, because we were rushed to the hospital in the middle of the night I hadn't packed anything. It was such a blessing when the nurse provided us with PJ's that were donated by Sweet Dreams for Kids, thanks Wendy!
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Umbrellas soften, broaden, and diminish the light output of any tungsten or flash light source. Umbrellas with a white interior will soften and weaken light more than an umbrella with a silver lining. A white umbrella without a black backing may also be used as a makeshift softbox, although the use of the light will not be as efficient as with a softbox.
Choosing umbrella size is determined by the size of the subject, and the strength of the light supply being used. Choosing an umbrella surface is as subjective as choosing a paint and brush.
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Flashcard Set Preview
Side ASide B
define abnormal psychology
the scientific and objective approach that describes, explains, predicts, and treats abnormal patterns of functioning
abnormal functioning/mental disorders are often characterized by? (4 d's)
Deviant, Distressing, Dysfunctional, Danger
Explain Deviant behavior
breaking off the morns of psychological functioning
What are the words used to describe bad stress?good stress?
describe someone who is experiencing distess
they have bad stress, which is often triggered by a mental illness in which the bad stress is out of their control
describe dysfunctional
the inability to deal with everyday functioning
list some ancient beliefs of mental illness
trephining, demonology, exorcism,
describe Greco-Roman beliefs of mental illness
looked for naturalistic explanations. Hippocrates began writing (father of modern medicine) believed mental illness was caused by brain pathology (disease), also considered heredity...
middle ages response to mental illness?
return to supernatural explanations because it was a time of great stress; began to blame the devil for their problems
what is mass madness?
a large group of people sharing the same absurd beliefs and symptoms
define tarantism-define lycanthropy-
"dance mania" people dancing like crazy for days or weeks in the street-belief that one is possessed by werewolfs-
what is the significance of Pope Innocent VIII
ordered all clergymen to find and exterminate the witches in a book titled "the Witches Hammel"
During the Renaissance what changes were made towards mental illness?
the idea of witchcraft was challenged by johaun weyer, the promotion of mental patients being taking care of, the building of asylums
Describe the Reform movement and important figures
-moral treatment movement in the 19th century, approach to treat people with mental illnesses with respect and carePhilipe Pind asylums to institutionsBenjamin Rush- physician who sparked...
Descriptive the Biological Perspective
people have mental illness due to chemical imbalance
list the most common neurotransmitters and their function
1) acetyl choline (ACH): activating muscles, attention and memory2) seratonin: regulates mood, appetite, memory, relaxation3)dopamine: controls voluntary movements4)norephinephrine...
disease believed to be caused by an imbalance of ACH
imbalance of seratonin can lead to....
anxiety disorders, mood disorders, eating disorders
lack of dopamine can lead to ....
parkinson's, schizophrenia
define endorphins
body's pain killers; in charge of mood, appetite, and perception of pleasure
describe the psychoanalytic approach/perspective
refers to Freud's structure of personality (Id, ego, and superego) and how conflicts between them are responsible for mental illness
the self centered, impulsive, irrational, illogical, immoral aspect of personality
the conscience, moral-based "guilt voice"
the reality based aspect of personality; rational, logical
what are the three forms of anxiety explained through the psychoanalytic model
moral anxiety: fear of one's own conscienceneurotic anxiety" fear of wanting to do something and the possibility of getting punished for it reality/objective anxiety: fear of tangible...
Describe the Sociocultural Perspective and the two perspectives included:1) Family Perspective2) social discrimination
emphasizing the ways individuals are influenced by people, social institutions, and social forces in their environment1) abnormality is caused disturbances in the patterns of interactions...
Describe the -cognitive/behavioral perspective
cognitive: disorders due to faulty/ irrational thinking; can be cured through therapy etc.behavioral: abnormality is caused by faulty learning of behavior, solved by behavior modification...
Describe the Humanistic Perspective
generated from Maslow's Hierarchy of human needs, focused on growth and adaptability. States that humans have an inherent tendency to strive for self fulfillment (prove oneself and...
system of diagnosis/classifications used by DSM that requires classifying a patient's behavior is 5 different dimensions
Multiaxial Assessment
Name the five axes
Axis 1: Clinical DisordersAxis 2: Personality Disorders and Mental RetardationAxis 3: General Medical ConditionsAxis 4: Psychosocial and Environmental ProblemsAxis 5: Global assessment...
What are some things that would fall under Axis 1: Clinical Disorders?
Anxiety, Eating, Mood, Schizophrenia, Sleep, Substance-related disorders
What are some things that would fall under Axis II: Personality Disorders/Mental Retardation
Antisocial, Obsessive Compulsive, Paranoid, Schizoid, Mental Retardation
What are some things that would fall under Axis III: General Medical conditions?
diabetes, high blood pressure, cancer etc.
What are some things that would fall under Axis IV: Psychosocial/Environmental Problems?
1) problems with primary support group2) problems related to social environment3) educational problems4) occupational problems5) housing problems6) economic problems7)problems with...
what would be the normal score range on the GAF scale?
a procedure in which a clinician evaluates the person in terms of the psychological. physical, and social factors that could influence the person's functioning
psychological assessment
series of open ended questions aimed at determining the client's reasons for being in treatment, symptoms, health status, family background, and life history
unstructured interview
what is the difference between personal history and family history?
personal: has to do with self; relationships,school, peersfamily: major events in the lives of relatives
standardized series of questions with predetermined wording and order
structered interview ; MC/TF/matching yes/no
standardized series of questions in which the interviewer has the discretion to ask follow up questions that will clarify the person's responses
semi-structured interview
assessing the client's behavior and functioning with particular attention to the symptoms associated with psychological disorders
mental status examination
What to look for in regards to appearance and behavior during a mental status examination
hyperactivity, psycho-motor agitation, psycho-motor retardation, compulsion, catatonia,
what is orientation refer to in a mental status examination?
an individual's awareness of time, place, and identity
under content of thoughts in a mental status examination; unwanted thought, word, phrase, or image that persistently/repeatedly comes into a person's mind and causes distress
false beliefs that are not consistent with client's intelligence or cultural background
client's choice of vocabulary and sentence structure
thinking style/language
an individuals outward expression of emotions
inward experience of emotion
name and describe the 3 types of mood
euthymic: normal, indifferent day to daydysphoric: extreme sadness/irritabilityeuphoric: cheefullness/ecstatic/elated
an imaginary sensation that does not exist in the real worlds; visual are the most common
an altered experience of self, such as feeling out of body experience
lacking a clear sense of who one is
identity confusion


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Smile Quotes, Sayings about smiling - Page 10
Smile a lot it costs nothing…
The more wrinkles you have, the happier you've made your life
Smile when you die, you'll be greeted like Gods/ Goddesses up in heaven
A smile makes the long distance seem short, and the bad times seem good.
Friends and laughter are the cause of a smile
Smile…something like a rumour… But the difference is that no one minds if you spread it !!
One of my current quotes that I made up is.
"Smile today to get a smile for tomorrow.
When you smile at someone and they don't smile back don't be angry at them, feel sorry for them because they aren't happy people.
Be yourself n smile, never be too scared to show your soft side… Who knows, may be when you smile, at that very second, you can carve it right in to a beautiful heart that will love you for all eternity… Remember the best things in life are priceless just like a smile…
A winning smile makes winners of us all.
Smile, it covers up the fear and sadness.
Smile- It makes people wonder what you're up to. :)
Wrinkles should merely indicate where smiles have been.
– Mark Twain


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Internazionale Domus
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Travel Blogs from Rome
Tue 9th - Fri 19th June 2015, Spain, France, Italy
... way back, and therefore a much shorter ride. We decide to pay the toll to get the benefit of the faster motorway and drive to St Feliu de Guixols, part way towards the Spain/France border. We find a Ruby-size space in the aire and after a scowl from our new neighbours, move her further from their van before retiring for the night. In the morning, we walk the short distance to the beach at St Feliu and we are in for a treat. It is warm, clear and very pretty. Snorkelling ...
... more crazy than how we get entertainment out of things like saw these days... We walked around and took lots of pictures and then headed out. Right next door was the Roman Forum and the Palatine hill. Entry to that was also included with our colosseum ticket so we went straight in again.
That place was huge and you could probably spend a whole day just going around there if you wanted to. There was one area (Palatine hill) which used to be a huge palace type place ...
Rome- churches and fountains
... the inside of all these churches was so detailed and tons of marble! We saw Santa Maria degli Angeli which was Michelangelo's last piece of architecture when he was 83. It had the most gorgeous Pipe organ that was huge! I would have loved to hear it play! Stopped off at Piazza Vittorio to see the Guirdini Piazza then onto Santa Maria Maggiore (worlds oldest church dedicated to the Virgin Mary) San ...
Sailing the ocean waves
Not much internet in the middle of the ocean but needless to say we are having a wonderful time. The ship is absolutely fantastic. So big. I walk out of my cabin and get lost every single time. 16 floors! The food is fantastic. So much of it. Drinks are great too. Lovely cocktails and Chandon! Stopped at Naples and did our tour down the Amallfi Coast. Of course it ...
The "Caesar Shuffle"
... satiate our hunger. On our way to lunch we stopped into a few shops, one of which was a genuine Italian leather shop. All of the purses, bags, and other accessories were entirely handmade from Italian leather. I ended up purchasing a gorgeous cross body bag and wallet. From there we walked through a marketplace to lunch, where we ate pizza. After lunch, we shopped and explored a bit all while making our way toward ...


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The student and I went through the directions for each section and talked a lot with her mom about how to check over her answers and not feel pressured on the test. Now that she has taken it, it seems like we will need to have a different approach in explaining how to go through it.
Today, the student and I added on vocabulary words from e to g (ending with graceful). We then reviewed area of triangles. We covered essay strategy, and I will be assigning an essay prompt for her to complete for Wednesday. Lastly, we went over homework and reviewed the problems she missed. I will be assigning her vocabulary, an essay, and extra math problems for homework. No concerns.
We worked on an essay practice and then he did some reading comprehension questions. For reading comprehension, he did well also.
I covered adding/subtracting decimals, adding/subtracting and multiplying/ dividing negative numbers, reducing fractions and converting fractions to decimals and back again with the student. I also went over Practice Exam Drill 1 and Easy Analogy Practice Exam Drill 2. I left him some notes on fraction as homework to cover next week.
Today the student and I worked through a diagnostic test for the Math section of the assessment lower level test. We spent the second half of the session going back over certain problems. She will practice with these concepts before our next sessions, and I gave this list to her parents.
We began with math using the test prep book. We looked at a list of math terms/definitions that the test expects you to know. The student circled the words he was unsure of and we discussed them. The test uses words like integer, consecutive, quotient, sum, and product in its questions without defining them. I made a chart for him of the four operations and words associated with them. He can add to this chart as he comes upon more terms. Reading: we read three passages. He did well on one passage from the practice test. We will continue to work on these. We ended with some analogies; he is making great progress on these. Homework: 1) continue learning multiplication table, 2) continue learning vocab words.
The student completed a practice verbal reasoning test and a practice reading test. She scored well on both. She got 15/20 problems correct on the verbal reasoning test, and she got 10/12 problems correct on the reading test. She reported she was anxious about her test. We talked about different ways to manage test anxiety, and we practiced staying calm during timed tests. She was able to retake the verbal reasoning portion of the test with a perfect score. She should study the 6 equations we have been practicing before tomorrow. She is quick to learn new material, and she does very well when she is calm and focused.
In this session, we tackled the verbal section of the SSAT. I brought my own book, and we tackled the synonyms section of the SSAT. I assigned him a few questions, and we went over each one. We discussed the words, the meanings, the synonyms, and made sentences. We plan on tackling the math section in the next session.
We talked math testing strategies while going over the following content: converting between fractions/decimals/percents, ratios, combining like terms, hands on equations, and solving equations on paper.
For math, we reviewed order of operations by evaluating expressions with 5+ operations. We also covered factors, common factors, and greatest common factors. For verbal, we formatted a plan of attack for analogies: identify the relationship type, make a sentence bridge, and apply it to each of the five word pairs.
The student and I started off by doing a review of geometry concepts. We went over perimeter and area of different shapes as well as total degree measures. I taught her about special right triangles and reviewed the Pythagorean Theorem with her. After doing some practice assessment math problems, we went over reading strategy and practiced with two single short passages.
Today the student and I met for the first time. We reviewed the scores for his practice test and identified areas where we thought we could work to make the most improvement and help his overall score. He and I are going to place a strong emphasis on algebra and working with word problems. For next time he is going to work on studying vocabulary words for the verbal section.
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Sierra Sage formulas are created using timeless herbal wisdom with Organic ingredients to produce Food for Your Skin™. Free of petroleum, chemicals and other harmful ingredients. We strive to bring the farm into the pharmacy by carefully selecting only the purest, most sustainable herbs and essential oils to create medicinal everyday products.
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Our herbs are carefully sourced from organic farmers, consciously wild crafted, or organically grown in house. We infuse our fresh and dried herbs in organic oils, rather than using premade extracts, to increase the medicinal value of our products. This enhanced process maximizes the potency of our salves taking the healing properties to the next level. We don't just offer products that soothe and moisturize, we craft products that make a difference in your life!


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Send to a friend!
Make my home page
Bush Tucker and CKD I Education Videos I Health Research I Home Country News I Indigenous CKD Stats
These organisations are committed to the education and care of Indigenous Australians.
Aboriginal Interpreter Services - Our Languages Map with languages spoken in each area
Other interpreter Services for Indigenous Australian language
Health Consumers of Rural and Remote Australia: People with different backgrounds and experience come together under one banner because they believe Australians living in the rural and remote areas of this country have the right to receive a reasonable level of health care.
Indigenous Allied Health Australia: For health professionals, to network or share information and ideas.
Menzies School of Health Research: 08 8922 8196 or email@example.com
NPS Medicine Wise: Blood pressure resources for Aboriginal and Torres Strait Islander peoples
Indigenous Australian Working Carers: Resources and support for low income and busy carers juggling caring and workplace demands. Of particular interest to isolated, regional and culturally diverse carer groups.
Other important patient focused resources for Indigenous Australians
Heart Smart Mobstyle Resources National Heart Foundation - students & teachers
Renal Resource Centre * Aboriginal health: patients & health professionals


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10th St 3-day schedule Advance entries Alex Amateur Annual Arthur Bisguier awarded Black resigns Blitz Chess Association Chess Center Chess Championship Chess Federation Chess Hall Chess Trust clock commit before rd Continental Chess Correspondence Chess credit cards OK cxd4 diagram e-mail endgame Entry fee FIDE Grade Grand Grandmaster Hall of Fame Hikaru Nakamura Hotel Jaan Ehlvest July king knight Larry Larry Evans Lev Alburt mailed Marshall CC Marshall Chess Club Master mate memb membership Michael move National Nxd4 Nxe4 on-line registration online at chesstour.com Pal Benko pawn Phone entry play players prize fund Quads Re-entry req'd reserve rook round Route 9W Salisbury Mills score Sept Sergey Kudrin SICILIAN DEFENSE Susan Polgar tournament Trophies to top U.S. Chess U.S. Open Unrated USCF USCF members White winner www.cajunchess.com


text: Images from the battle of Gettysburg, July 1 – Jul 3, 1863. The pictures, photos and images you see below are actual pictures taken from the battlefield during the battle. Pictures include a harvest of death, picture of John L Burns, a picture of dead animals by artillery, a map of the town of Gettysburg, an image of the battlefield, photo of breastwork on Little Round Top, a picture of a crowd centered around President Lincoln after the Gettysburg address, an image of Culps Hill, picture of Confederate Dead, and a painting of Picket's charge. *Gettysburg pictures courtesy of the National Archives A Harvest of Death. Gettysburg, July 1863. (National Archives) John L Burns, the oldest man in the battle. (Library of Congress) Dead artillery and animals. (Library of Congress). A Gettysburg period map. Crowd at Gettysburg, November 19, 1863. Lincoln in center. Breastworks on Little Round Top, left from Day Two At Gettysburg. Culps Hill. Entrenchments for an artillery battery in the foreground indicate that this photograph was taken in 1863. (National Archives) Confederate dead at the edge of Rose Woods George Pickett's division comes under Federal rifle fire as they near the Union lines on Cemetery Hill. This scene portrays the death of Confederate Brigadier General Garnett. (U.S. Army Center of Military History) For information on the battle of Gettysburg, visit our Battle of Gettysburg theme page.


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Last Updated: July 8, 2011 03:54pm ET
Regional Developers Get Financing
NEW YORK CITY-Some regional developers are getting financing, but mainly only in the multifamily sector, said Stephen Duffy, managing director at Moss-Adams Capital. In a conversation with GlobeSt.com's Ian Ritter he revealed that most new development is still only taking place in large primary markets.
They also talked about:
- The popularity of multifamily in tertiary markets.
- How the housing market impacts the multifamily sector.
- The possibility of multifamily oversupply.
Cocktails and market intelligence are on the agenda at RealShare NEW YORK on October 14 from 1:30 pm - 7:00 pm. Register today to confirm your space.


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