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£375 pcm
1 bedroom apartment to rent Throstlenest Avenue/Court, DarlingtonA well presented one bedroom deceptively spacious first floor apartment located in a modern residential development in the Haughton area of Darlington close to shops and bus routes in and out of town. The property would be ideal for single persons or couples. Viewing is recommended. Coun... More details ›
£395 pcm
1 bedroom apartment to rent Victoria Road, DarlingtonWithin a short walk of the town centre is this well presented one bedroom apartment. This first floor property is perfect for the couple or single tenant as it comes with modern fixtures and fittings throughout. More details ›
£355 pcm
Studio flat to rent 129 Victoria Rd, Dl1ALL BILLS EXCEPT COUNCIL TAX included in this centrally located studio apartment in the heart of Darlington town centre, Victoria Road offers excellent commuter links for professional tenants working throughout the North East. More details ›
£450 pcm
1 bedroom apartment to rent SOUTHEND AVENUE, Darlington, DL3SOUTHEND AVENUE, DARLINGTON UNFURNISHED A well presented one bedroom apartment situated in a Period Town House in the much sought after West End of town and within easy walking distance to the Town Centre. More details ›
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1 bedroom flat to rent High Northgate, DarlingtonWe are delighted to offer To LET this outstanding one bedroomed apartment situated within the Northgate Area of Darlington. The property is close to all local amenities and North Road Railway station. The property has been substantially upgraded and a internal inspection is strongly encouraged... More details ›
Added on 05/10/2015 by Northgate Estate Agents & Property Management, Darlington. Call: 01325 627342 Local call rate
£300 pcm
1 bedroom flat to rent Raby Street, DarlingtonNO ADMIN FEE / TOWN CENTRE : Fully modernised first floor flat with GCH and double glazing. The property benefits from a lounge and fitted kitchen to the front aspect which includes an electric cooker and fridge and one double bedroom to the rear there is also a shower room and separate toilet. More details ›
£350 pcm
1 bedroom flat to rent Fulthorpe Avenue, Darlington, County Durham, DL3Refurbished 1 bedroomed first floor flat above shops, in convenient location. More details ›
Added on 02/10/2015 by Property Management North East, Darlington. Call: 01325 627338 Local call rate
£375 pcm
1 bedroom ground floor flat to rent Greenbank Road, DarlingtonThis newly renovated flat on Greenbank Terrace, Darlington is now available. Includes a new Gas central heating system. New Double Glazing. New carpets throughout and freshly painted.Close to the Town Centre and all of its amenities. More details ›
£425 pcm
1 bedroom apartment to rent Haven Gardens,Darlington,DL1HAVEN GARDENS DARLINGTON FURNISHEDTop Floor One Bedroom Apartment in a Quiet Development in the Eastbourne area of town with Accommodation More details ›
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1 bedroom flat to rent North Road, DarlingtonA Modernised One Bedroom Flat Situated on North Road Darlington. Available Late October, In Brief The Property Comprises; Entrance Hall With Stairs To First Floor Landing Recently Fitted Kitchen, Lounge, Recently Fitted Shower Room Bedroom Rent £295 | Bond £340 | Admin Fees... More details ›
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Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist
1 Department of Biopathology, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy
2 Interdisciplinary Centre for Bioinformatics and Biostatistics, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy
3 Department of Public Health and Cell Biology, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy
4 Department of Pediatrics, La Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy
5 CASPUR, Consortium for Supercomputing Applications, Via dei Tizii 6, 00185, Rome, Italy
6 Deptartment of Biology, Tor Vergata University, Via della Ricerca Scientifica 1, 00133, Rome, Italy
7 St. Peter Fatebenefratelli Hospital, Via Cassia 600, 00189, Rome, Italy
8 Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas, Veterans Healthcare System, Little Rock, AR, USA
BMC Genomics 2010, 11:497 doi:10.1186/1471-2164-11-497Published: 16 September 2010
Congenital heart defect (CHD) account for 25% of all human congenital abnormalities. However, very few CHD-causing genes have been identified so far. A promising approach for the identification of essential cardiac regulators whose mutations may be linked to human CHD, is the molecular and genetic analysis of heart development. With the use of a triple retinoic acid competitive antagonist (BMS189453) we previously developed a mouse model of congenital heart defects (81%), thymic abnormalities (98%) and neural tube defects (20%). D-TGA (D-transposition of great arteries) was the most prevalent cardiac defect observed (61%). Recently we were able to partially rescue this abnormal phenotype (CHD were reduced to 64.8%, p = 0.05), by oral administration of folic acid (FA). Now we have performed a microarray analysis in our mouse models to discover genes/transcripts potentially implicated in the pathogenesis of this CHD.
We analysed mouse embryos (8.5 dpc) treated with BMS189453 alone and with BMS189453 plus folic acid (FA) by microarray and qRT-PCR. By selecting a fold change (FC) ≥ ± 1.5, we detected 447 genes that were differentially expressed in BMS-treated embryos vs. untreated control embryos, while 239 genes were differentially expressed in BMS-treated embryos whose mothers had also received FA supplementation vs. BMS-treated embryos. On the basis of microarray and qRT-PCR results, we further analysed the Hif1α gene. In fact Hif1α is down-regulated in BMS-treated embryos vs. untreated controls (FCmicro = -1.79; FCqRT-PCR = -1.76; p = 0.005) and its expression level is increased in BMS+FA-treated embryos compared to BMS-treated embryos (FCmicro = +1.17; FCqRT-PCR = +1.28: p = 0.005). Immunofluorescence experiments confirmed the under-expression of Hif1α protein in BMS-treated embryos compared to untreated and BMS+FA-treated embryos and, moreover, we demonstrated that at 8.5 dpc, Hif1α is mainly expressed in the embryo heart region.
We propose that Hif1α down-regulation in response to blocking retinoic acid binding may contribute to the development of cardiac defects in mouse newborns. In line with our hypothesis, when Hif1α expression level is restored (by supplementation of folic acid), a decrement of CHD is found. To the best of our knowledge, this is the first report that links retinoic acid metabolism to Hif1α regulation and the development of D-TGA.

subset: commoncrawl


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A procedure is described by which the design of a corner fed nearly square microstrip patch antenna is optimised with respect to the perturbation element in order to produce circular polarisation. New fast form expressions are used to determine the individual orthogonal mode impedances based on the Green's function approach
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Super 8 Mesa Gilbert
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It gets to 100 degree temp!
... the cop we met in Jerome recently. We really enjoyed them – he is also a writer and gave us each a book (we had one of ours sent to him later) and also gave us some rocks with minerals, esp silver, from ----the Lost Dutchman Mine – that is what his book is about and he has actually found it . Out to lunch with them and then home. A fun and informative day. Dinner at Scuttlebutt's.
April 16th- I had dr appt this ...
... storming this morning and 2 more predicted for later in the week. Out to eat at Carrabbas for an Italian dinner, but really has fast food Italian food. Liked the people there but not the food. Phil seems to be coming down with a cold.
February 10, 2015-Tuesday-Phil does have a cold and thinks I gave it to him, but I do not have a cold. I went to PO and then bought cold meds for him this morning. We did play pool tonight and then had leftovers ...
Work & Play with Jim, Connie & Rowdy too!
... Spike National Historic Site in UT… and having an HO gauge train when I was a kid growing up.
So we decided to venture out and see the sites… we've visited several sites like this in the past…There's 2 or 3 locations in WA, we've been to 2 of the sites in OR but this is the largest we've seen… They say they have 35 miles ...
Happy Birthday Myra
... those ideas for clients, but only reluctantly. We stopped at a Target and bought a Scrabble game, spent the afternoon by the pool and had Chalupas for supper with the leftover chicken. The Scrabble game was very close, but Doreen pulled ahead of me at the end and Derry played the Q which brought him into second place, this after I had lead from the first ...
A relaxing time at home
... above—she didn't want to show her face after lying to us about our bill!! Had same breakfast as yesterday but no juice as Carol had left that locked to us. So after 11 finally able to leave town. Carol dresses like a frilly, fluffy gypsy whose feet, and mind, float and do not reach the ground. Next stop was at Tombstone where we had a buffalo burger for lunch. I had some photos that we took last trip here – they turned out good- and ...


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Annapolis Jaycees - 20s & 30s Volunteer, Networkin Message Board › New Meetup: American Idol OR NOT!
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Announcing a new Meetup for 20's & 30's Networking and Social Group - Jaycees!
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Riva, MD 21140
Hey everyone, come on out to Mikes Crab house, www.mikescrabhouse.com, for some good drinks and karoke. Don't worry if you can't sing, no one will care! It is all about how much fun you have!
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Editor's Note: This story was orginally published March 2, 2007
Todd Palin, Alaska's new first spouse, has taken a leave of absence from his blue-collar job working on the North Slope for BP. Palin, husband of newly elected Gov. Sarah Palin of Wasilla, will instead work part-time for his union, the United Steelworkers Local 4959, according to officials with the union and BP. The agreement between the British oil giant and the union allows Palin to come back to his job within a year and keep his seniority.
In an interview, Todd Palin said he is taking the leave not to avoid any conflict of interest but because the family's busy schedule makes it impossible for him to work regular shifts. He held out the possibility of going back to work in a matter of months, after life in the governor's mansion settles down.
"I've got a great job on the Slope," he said. "I just don't want to give it up."
Todd Palin's hourly wage job with BP creates a novel ethical twist in Alaska politics.
Conflicts of interest, outside employment and ethics reform are the subject of much debate in Juneau. Sarah Palin owed much of her electoral success last year to her image as an ethics reformer.
Few companies have as big a stake in state government as BP. The company is Alaska's No. 2 oil producer, runs most of the North Slope fields and owns half of the trans-Alaska oil pipeline. BP and the state are in constant contact over regulation, taxation and environmental oversight -- not to mention possible negotiations over a new gas pipeline.
On the other hand, Todd Palin's job as an hourly wage production operator at a Prudhoe Bay gathering center is far from the center of power in BP. Palin works both indoors and out at the facility, which separates water from crude oil and reinjects the water into the ground before sending oil down the pipeline.
As an officer in the steelworkers' local, Palin has also served on the union's negotiating team, said steelworkers local secretary-treasurer Glenn Trimmer.
"Trust me, that doesn't endear you to the company," Trimmer said.
Ethicist Michael Josephson of Los Angeles, who led a seminar on ethics for Alaska legislators this year, said he doesn't see much potential for conflict in Todd Palin's job. Not compared to some of the other conflicts he heard about in the Legislature.
The problem for Gov. Palin would be facing a decision about BP that could affect her family's income, Josephson said. If her husband were president of BP, the governor would have to recuse herself from just about everything that touched the oil company. In Todd Palin's case, state decisions are not likely to have much impact on the family, Josephson said.
But he added that some people might suspect BP of doing favors for Todd as a way to reach his wife. Therefore Todd Palin's leave of absence might be prudent.
"I don't think he had to do that," said Josephson. "I think it's a good thing he did. Let's take one more thing off the table."
The arrangement with BP, allowing Palin to retain his seniority as he takes a leave for union work, can last only up to a year under the current contract, said union official Trimmer. The leave began Jan. 25. New arrangements would have to be made for a leave in 2008 and thereafter.
"Obviously we didn't anticipate anybody within our ranks being in a position like he is," Trimmer said.
Keeping his seniority would help Palin hang on to his job in the event of layoffs, Trimmer said. He said Palin would receive a small stipend from the union for "very part-time work."
The steelworkers local represents about 500 workers in Alaska, mainly working for BP, Agrium, Crowley Maritime and Sitka hotels, Trimmer said. Todd Palin has been an elected trustee for the local, whose unpaid job is to audit the union's books, he said.
The Palins met at Wasilla High School and eloped in 1988.
Todd Palin, 42, has been the main family breadwinner for most of the time since. Working a week-on-week-off shift on the North Slope, he has taken time off to fish a commercial setnet site in Bristol Bay and to race a snowmachine in the Iron Dog, the cross-state race he and his partner won this year.
In an interview during the last month of her campaign, Sarah Palin said her husband would quit his job if she were elected. Asked about that election night, Todd Palin was much less definite, saying he hoped to work something out with BP, for whom he has worked at since 1989.
Todd Palin said his annual wages came to something in the neighborhood of $100,000. Sarah Palin makes $125,000 a year as Alaska's governor.
Todd Palin returned Wednesday from his first trip to Washington, D.C., where he toured sites, was impressed by high security measures, and attended functions of the National Governors Association. He said he enjoyed talking to other "first gentlemen" married to female governors. There are five of them.
The Michigan governor's husband gave up his business when she was elected in 2002 and now plays an active role in her administration, Palin said. The Kansas governor's husband was the first to coin the phrase "first dude." He is a federal magistrate, so in Kansas "they have to really watch their P's and Q's," Palin said.
Palin said he sees no conflict with his own oil-field job because he's not in management. He concedes others might see it differently.
"As a commercial fishing family, do I have a conflict?" he said.
Alaska's first family is still sorting out its new life, Palin said.
As first spouse, he said he'd like to focus attention on work force development and vocational training issues.
The Palins' son, Track, has returned from playing junior hockey in Michigan and is finishing out his senior year at Wasilla High. Their three younger daughters are attending school in Juneau. Sarah Palin's mother, Sally Heath, stayed with the girls while their parents were in Washington.
Working as a Sloper and commuting for weeklong shifts, Todd Palin said, it was always left to Sarah to play the supermom role when she was mayor of Wasilla. Now that's not possible.
"Our family is very adaptable," he said. "As long as the kids are good, that's the big decision whether I go back to work."
Reporter Tom Kizzia can be reached at firstname.lastname@example.com or in Homer at 907-235-4244.
By Tom Kizzia
Anchorage Daily News


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Tony Brice now thinks of hope when he walks into his home.
Hope in a community willing to come together for not just him, but for all veterans like him who return home and try to adapt to life away from war.
"There are people out there that are going to help," the 43-year-old U.S. Army veteran said, encouraging veterans to seek out the assistance available for them. "There is hope, reach out — don't be afraid to reach out."
BROOKSVILLE — Two committees, two widely divergent outcomes.
Members of the Hernando-Citrus Metropolitan Planning Organization's Technical Advisory Committee (TAC) and Citizens Advisory Committee (CAC) met Wednesday in Brooksville to discuss the rankings of transportation projects, and supporters of the Withlacoochee State Trail repaving project are unlikely to be happy with the results.
Some of the best marching bands in the state will compete at the 23rd annual Hurricane Pride Invitational Marching Band Festival on Saturday at Citrus High School.
On Wednesday, Joshua Dulen Illes, 18, was sentenced to four years in prison for sexual crimes he committed against two young girls when he was a minor.
INVERNESS — Hourly employees with the city of Inverness got a $1,000 across-the-board raise Tuesday night, thanks to a unanimous vote by city council.
The water district is in the midst of soliciting public input for its annual priority list and schedule for the establishment of minimum flows and levels.
Southwest Florida Water Management District officials say the process is designed to fulfill a mandate to establish withdrawal standards for all bodies of water in the district.
Service for slain Samaritan today
The state Department of Transportation (DOT) is facing a pair of violations for work on a drainage retention area that might have pierced the aquifer and piped plumes of muddy water to King's Bay near Hunters Spring.
John Powanda, compliance engineer with the Southwest Florida Water Management District in Brooksville, said Wednesday the DOT's claim that work on the drainage ditch was only routine maintenance doesn't hold up because of excavation that also took place.
BROOKSVILLE — The Technical Advisory Committee and the Citizens Advisory Committee will meet today in Brooksville.
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HP Enterprise's Whitman pans Dell's EMC purchase over debt
HP Enterprise CEO Meg Whitman tries to rally her troops to go after Dell's purchase of EMC.
The PC giant is working to diversify into software and services.
HP Enterprise CEO Meg Whitman tries to rally her troops to go after Dell's purchase of EMC.
Dell acquires EMC in a deal that creates the largest privately held technology company. The combined entity, which will be run by Michael Dell, is betting scale will sell to enterprises.
Dell is also said to have filed a confidential initial public offering for its IT and network security business, Dell SecureWorks.
This is not just a refresh with sixth-generation Skylake processors: Dell is also bringing XPS 13 styling and infinity displays to the 15-inch laptop market, and adding a 12-inch tablet/keyboard combo.
Last month, I was leaning towards going "all in" on iOS with an iPad Pro. Microsoft and Dell have made that decision much more difficult with new 2-in-1 products.
Dell and EMC would merge in what would be one of the largest leveraged buyouts. Strategically, the deal makes sense, but there's a catch. Dell and EMC still lack a public cloud story in a hybrid market.
The future of Office is in the cloud, and as Office 2016 evolves, it's Office 365 subscribers that will get the most benefit from new features.
Dell's latest take on a 2-in-1 laptop / tablet is very much like Microsoft's Surface Pro 4 but with one key difference: The included keyboard is a solid base, not a thin cover.
Dell is reportedly looking to merge with EMC, but it is still unclear whether it would be with the entire company or only partially.
As Dell continues to roll out its 'transform, connect, inform, and protect' strategy, the company is striving to be recognised as an end to end solutions provider -- not just a PC provider.
Citrix has reportedly approached Dell about a merger as it seeks to sell the entire company instead of parts.
Dell's Venue 8 Pro and Venue 10 Pro tablets enter what's becoming a crowded enterprise tablet space with Microsoft's Surface and Apple's iPad Pro. Dell's plan is to sell the services and management tools around the devices.
Foxconn's mega manufacturing complexes in Shenzhen have allegedly failed to pay a large number of workers their fair share of social security insurance and public housing.
You can thank Microsoft for leading the way with its Surface and Surface Pro. The Dell XPS 12 looks similar but is expected to offer a high-resolution 4K display with barely a bezel for Windows 10.
In an exclusive interview, Dell vice president Jeff Clarke explains the private company's solution-based approach to the enterprise market - Transform, Connect, Inform, Protect - and its renewed focus on selling PCs to consumers and small office/home office users.
Sales of servers are showing good signs of recovery in the US, but not in Europe.
The premium Android tablet from Dell is thinner than the iPad Air 2 and lighter than the iPad mini.
A Chromebook may be all you need for all your computing needs. Here's the best of the breed so far.
The Dell Precision‐powered smart desk has been created to give users augmented reality-like experience while they work.
School will soon be in session and a Chromebook may be just what you need for the coming academic year.
There are lots of Android tablets to choose from, ranging from the inexpensive to big bucks. These two tablets from Dell are light on the wallet and have a unique feature.
Most Windows hybrids are reasonable laptop substitutes with a keyboard dock. The Venue 11 Pro is a genuine laptop replacement with Dell's dock.
The most tech-savvy U.S. president to date, Barack Obama uses the best devices and technology for the job, in and outside of the White House. Here's a look at some of the devices, platforms and technology he uses to carry out his day-to-day presidential duties.
With back-to-school shopping in full swing, here's a look at 10 (mostly) affordable notebooks for students returning to the classroom. Most of them are helped by Intel's new fourth-generation Core processors (a.k.a. Haswell), which manage to improve both performance and battery life. That will come in handy for those all-night study sessions -- or YouTube viewing marathons.
Black Hat USA 2013 vendor area included companies such as Veracode, Booz Allen Hamilton and Microsoft, with creative schwag such as Botnets for Breakfast (cereal) and 'hacker' playing cards.
Dell's OptiPlex 9010, Latitude 6430u and Latitude 10 aim to keep IT managers happy while providing users with productive platforms for Windows 8.
The Victorian Education Department officially opened its latest "connected classroom" on Friday with the state's Education Minister Martin Dixon doing the honours.
Electronics retailer JB Hi-Fi today opened its latest concept store in the new Westfield complex in Sydney CBD and company CEO Terry Smart spoke to ZDNet Australia about how the store came to be.
Dell used to make some fantastic PDAs, but then had a rough bit of luck with smartphones. They then released the Dell Venue Pro Windows Phone 7 device, my personal favorite, and followed up with the similar Dell Venue Android device.
The Dell Venue Pro is the best Windows Phone 7 device available and with a 32GB microSD card mod it becomes even better. The device is unique with a 4.1 inch AMOLED display and portrait QWERTY keyboard.
The next Android tablet for T-Mobile is launching soon as the Dell Streak 7. While the Streak 7 has an NVIDIA Tegra 2 dual-core processor, HSPA+ 21 Mbps support. and $199.99 price after contract, the low resolution display and limited battery life make it a device to skip as better devices are available now or coming soon.
What's your most outlandish server disaster story?
At the Web 2.0 Summit in San Francisco, Michael Dell, CEO of Dell Computer, talks about the state of the PC industry, competition with HP, Apple's near bankruptcy in 1997, and the first time he met Steve Jobs.
At the company's event in San Francisco this morning, Dell showed several new models of laptops, desktops, and workstations, as well as a prototype of a 10-inch Windows 7-based tablet due later this year.
At the Intel Developer Forum in San Francisco, Dell's Dave Zavelson shows off the company's new 10-inch Windows 7 tablet. Its standout feature is the ability to open up the case, flip the screen, and then convert it into a laptop design. The tablet will be available later this year.
At Oracle OpenWorld in San Francisco, Dell CEO Michael Dell talks about how his company is delivering a more efficient enterprise with its services. He discusses Dell's plan to automate tasks and provide more visibility, allowing users to consume what they need when they need it.
At VMworld 2009 in San Francisco, Praveen Asthana, Dell's VP of storage and networking, talks about the company's virtualization strategy and how it plans to optimize the data center with fewer tools.
ZDNet Senior Editor Sam Diaz talks about the company's effort to sell its products to the SMB market. He says Dell executives are hoping to gain ground on the competition by retooling offerings to be more customizable.
There is much to both love and hate about Dell's M109S projector. It has a very low resolution, gets seriously hot, and is only 50 lumens in brightness. At the same time it's tiny, has the longest lamp life we have ever seen, and is mercury free.
Dell's Latitude E4300 shares many of the exciting features of its larger siblings, but also sacrifices a lot in exchange for portability.
ZDNet Senior Editor Sam Diaz says Dell's recent product announcements show the company is positioning itself for a comeback, and he believes Dell's entry into new product categories like lightweight laptops and wireless music players is a step in the right direction.
Steven Schuckenbrock, CIO of Dell and Senior VP of the computer makers' multi-billion dollar Global Services business talks with CNET News.com's Dan Farber about transforming IT at the venerable computer maker and the company's "green" promise. He also speaks about developing cloud computing and software-as-a-service solutions for its customers around the world.
At Oracle OpenWorld in San Francisco, Dell CEO demos the company's new convertible Latitude XT, which he claims is thinner and brighter than competing systems. It also has multitouch technology that senses the five fingers of a hand.
At Oracle OpenWorld in San Francisco, Sun Microsystems CEO Jonathan Schwartz and Dell CEO Michael Dell share the stage to announce that Sun's open-source operating system, Solaris, will be shipping on Dell servers.
At the Gartner Symposium/ITxpo in Orlando, Fla., Dell CEO Michael Dell talks to Gartner research analysts about the company's vision for green IT. Dell explains his company's commitment to being carbon neutral, and his plan to build more energy-efficient desktop and server products.
At the Gartner Symposium/ITxpo in Orlando, Fla., Dell CEO Michael Dell talks to Gartner research analysts about the company's renewed focus on customer-centricity, such as the company's plan to introduce new notebooks and a move into on-demand streaming.
Nicely built with a superb 15.6-inch Ultra HD screen, a Core i7 processor and plenty of configuration choices, Dell's Precision M3800 mobile workstation is an excellent notebook with few serious drawbacks.
The PowerEdge T630 is a powerful and highly configurable server workhorse for small to medium-sized businesses wanting to cash in on the benefits of the latest processor, memory and storage technologies.
The premium Android tablet from Dell is thinner than the iPad Air 2 and lighter than the iPad mini.
With latest-generation Xeon processors, DDR4 RAM and a wide choice of GPUs, Dell's new Precision workstation is equipped to handle applications needing extreme processing power as well as high-end graphics. Storage options are limited, but otherwise it's an excellent and flexible workstation.
It's difficult to fault the Dell Latitude 14 Rugged Extreme on toughness grounds. However, you're unlikely to get day-long battery life from the entry-level configuration with the standard 6-cell battery.
Dell's latest top-end all-in-one desktop offers an excellent range of security options and can be configured to handle a variety of business workloads.
Take a blade server, add shared storage, PCI expansion and networking and you have the Dell PowerEdge VRTX. It's a surprisingly scalable yet affordable all-in-one system aimed at small businesses, but attracting interest well beyond its intended market.
The Atom-based Latitude 10 is short on performance, but delivers excellent battery life — especially with the optional 4-cell battery. Although some aspects of the industrial design and build quality could be better, this is a decent business-class Windows 8 tablet.
The swivel-screen XPS 12 offers clever design, solid build quality and a high-quality (if reflective) screen. Battery life is not great, though, and this system is severely lacking in connectivity — even by ultrabook standards.
It's not the most powerful or scalable 2U server in Dell's PowerEdge range, but the R520 is still a quick, capable and affordable dual-socket platform that can be configured to handle a variety of both datacentre and distributed office workloads.
The tower equivalent of the rack-mounted R720, Dell's PowerEdge T620 sports the same processor, RAM and management options plus even more flexible storage. It's a powerful and versatile platform that can cope with everything from standard file and print duties through distributed branch office applications to private cloud deployment.
The Latitude E6430s is a solidly built and highly configurable 14in. business notebook with excellent security and remote management features. However, some may find it just too big and heavy to take on their travels.
The Vostro 3560's 1080p screen is well worth the extra outlay, and rest of the specification is solid, although we'd like more storage options. The physical design is unremarkable, the keyboard a little too flexible and battery life disappointing, but it's still good value for money.
Dell has done a lot more than simply upgrade the PowerEdge T320 to the new Xeon E5-2400 processor. Memory and storage also get a huge boost, and there's optional iDRAC 7 management and an embedded hypervisor option, making this a real SME power platform.
The Dell PowerEdge R815's core density is impressive, setting it up neatly for virtualisation duties. Using AMD's 6000 series processors, it hits 48 cores across only four sockets, all in a 2U chassis.
Dell launches the world's smallest 15 inch laptop, updates the XPS 13, and previews the XPS 12
Dell and EMC: A big buyout, but will scale pay off vs. hyperscale cloud?


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How to use Masonry Chisels
Masonry chisels are much heavier and wider than wood chisels. They are used in conjunction with a two-pound hammer to remove sections of masonry or other hard materials, such as wall tiles.
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text: We stay at the Bee and Bee every fall for our annual Ladies' weekend. We book all the rooms which are comfortable and clean and the breakfasts are scrumptious and exquisite.. Jane and Tony have become friends over our 8 years of return visits. Looking forward already to our already booked 2016 stay..


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Welcome to the Thompson Health Family Practice in Victor!Health care for the whole family.
Pediatrics • Adult Medicine • Women's Health • Newborn Care 53 West Main StreetVictor, NY 14564585-924-0690 Office HoursMonday-Friday: 8:30 a.m.-4:30 p.m. Closed daily for lunch 1-2 pm Meet our StaffJohn Sharza, MDJohn McGuire, MDElisabete Sharp, MDJennifer Mead-Samuels, PA
The following practices are accepting new patients.
• Macedon (NP Susan Quinn)
• Midlakes (Ages 18+)
• Victor


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Apparitions in the Shadows of Moonlight
Release Day is Here
Here it is, the 8th of the 8th 2015 and with the coming of that, comes "EIGHT" Our eighth album, available as a download from Bandcamp, CDBaby or physical from Amazon.
Hope you enjoy it.
Promo Shot
As much as I hate being photographed, the label demanded a new promo shot so for those interested it's on the BIO page.
Pre-Order Eight
Eight (with its revised cover) is slotted for release on the 8th August 2015, you can pre-order a download version below, but between then and now included here are a couple of teasers.
#Sinultimata #Eight #Bandcamp #Amazon # ProgressiveElectronic
Banned/Refused Cover
Oh goody, a banned/refused cover. How the *****n' hell can this be classified as porn????? It's bloody fantasy for **** sake!! Bloody PC Brigade wouldn't know art if it bit 'em on the arse. Why it wasn't pulled up before hand is beyond me, so now it's back to the drawing board as I flat REFUSE to modify it!
#Amazon #Sinultimata
Arturia – Moog
There are some days that it's easier to walk away from the studio and just 'play' – today is one of those days, no modulars, no vintage analogue synths, no workstations, just me, the Moog Little Phatty (granted not standard as far as presets go) and the new Arturia.
I've heard numerous comments on the Arturia Beatstep Sequencer, rating it from awful to good. Well you can take it from me, it (for the price) is a decent piece of kit. There are many times like today when the modular does my head in and I just want to sit in the quiet room and let my fingers do the walking with some of my favourite presets and when the Moog is running sequenced I can jump from piano on the Roland to something spacey on the MS2000 Korg.
The only thing I don't like is the fact it's way too flat appearance wise. So with that said I wandered out to the workshop (yes I have a workshop) and built the nifty stand for it – well me and the CNC machine built the nifty stand 😉
I'm not an authorised official spokesman for Arturia, but I don't mind sharing info if I like something.
Here's a picture
The Interval In Illusion
Just a teaser from the upcoming album 'Eight'
RIP Edgar – Diolch yn fawr Edgar, diolch yn fawr.
I'm still numb after hearing Edgar Froese passed. It was him, Tangerine Dream, Neuronium and the like that gave me the drive to continue with electronic music, you will be greatly missed.
Diolch yn fawr Edgar, diolch yn fawr.
Sinultimata T-Shirts
We'll be listing some T-Shirts for sale shortly, there are currently two different ones, available in all colours but the black looks sweet 😉
We'll put up the link shortly to where you can get them from.
So it appears we're naughty?
Apparently, a leaked copy of the full cover of Dychwelyd y Ddraig Goch has upset some people, it appears we can't make a concept album without the PC Brigade sticking their 2 bobs worth in.
I'd like to say what's really on my mind but going off on one will achieve nothing, so instead I'll let you decide if the concept of the Welsh driving the invaders from the east out with the Red Dragon actually means driving the English out, does it really say who those from the east are, 'NO' – so as far as I'm concerned the PC Brigade are seriously bent.
Seeing as the full cover has been leaked, the image below is the proof of the back – you tell me if it's offensive. Plus you may as well have a chuckle at the email.


text:
Page 1
Science in medicine
??The?Journal?of?Clinical?Investigation http://www.jci.org Volume 116 Number 1 January 2006
Biological basis for the cardiovascular
consequences of COX-2 inhibition:
therapeutic challenges and opportunities
Tilo Grosser, Susanne Fries, and Garret A. FitzGerald
Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
One should not increase, beyond what is necessary,
the number of entities required to explain anything.
— Occam's razor
Arachidonic acid (AA) is subject to metabolism by prostaglandin G/H
synthase (PGHS; commonly known as COX) enzymes, lipoxygen-
ases, and epoxygenases to form a mesmerizing array of biologically
active products. The COX enzymes are bisfunctional proteins, pos-
sessing both COX and hydroperoxidase (HOX) activities, catalyzing
the biotransformation of AA into the PG endoperoxide intermedi-
ates PGG2 and PGH2. These are, in turn, acted on by isomerases and
synthases to form the PGs and thromboxane A2 (TxA2) (1–3). All of
these products activate G protein–coupled receptors; the phenotypes
resulting from deletion of these receptors has informed considerably
our understanding of prostanoid biology (4). NSAIDs, which include
both traditional NSAIDs (tNSAIDs) and selective inhibitors of COX-2
and which are among the most commonly used drugs (5), relieve pain
and inflammation by suppressing the COX function of PGHS and
the consequent formation of PGE2 (6) and prostacyclin (PGI2) (7), but
perhaps also of other prostanoids. The failure of NSAIDs to inhibit
PGHS HOX–dependent free radical formation may contribute to the
failure of these drugs to modify disease progression in arthritis (8).
Several groups made observations (9–12) that predicted the dis-
covery of a second COX enzyme (13–15). Unlike COX-1, which
appeared to be expressed constitutively in most tissues, COX-2 was
subject to rapid induction by inflammatory cytokines and mito-
gens and was speculated to account largely if not exclusively for PG
formation in inflammation and cancer. Drug screening in cellular
and biological systems identified compounds selective for COX-2
(16, 17). The elucidation of the COX structures subsequently
explained this capability (18, 19). The COX enzymes are remarkably
similar, both sharing a hydrophobic tunnel that affords access of
the lipid substrate to the active site, deep within the proteins. How-
ever, the COX-2 tunnel is more accommodating and includes a side
pocket not present in COX-1 (Figure 1). This affords both broader
substrate recognition and a structural explanation for the ability to
detect drugs selective for COX-2 in pharmacological screens (20).
The attraction in developing such compounds was that they might
not induce the commonest complication of tNSAIDs — gastroin-
testinal (GI) intolerance — which the "COX-2 hypothesis" attrib-
uted entirely to inhibition of COX-1–derived protective PGE2 and
PGI2 by gastroduodenal epithelium and platelet COX-1–derived
TxA2 (21). Subsequently, the simplicity of this concept has been
challenged by increasing evidence supporting the importance of
COX-2 in resolution of mucosal inflammation and in ulcer healing
(22). Despite this and epidemiological evidence suggesting that the
incidence of severe tNSAID-related GI adverse effects was in decline
(23), the race for the approval of drugs designed as COX-2–specific
inhibitors gained momentum. The conventional bases for approval
by the FDA of the first 3 of these drugs — celecoxib, rofecoxib, and
valdecoxib —were relatively small: clinical studies consisted mostly
of hundreds of volunteers and were short-term (mostly less than 6
Nonstandard?abbreviations?used: AA, arachidonic acid; APC, Adenoma Prevention
with Celecoxib; APPROVe, Adenomatous Polyp Prevention on Vioxx; CABG, coronary
artery bypass grafting; CLASS, Celecoxib Long-term Arthritis Safety Study; EDGE,
Etoricoxib versus Diclofenac Sodium Gastrointestinal Evaluation; EMEA, European
Medicines Agency; GI, gastrointestinal; HOX, hydroperoxidase; IP, PGI2 receptor;
MEDAL, Multinational Etoricoxib and Diclofenac Arthritis Long-term; PGHS, pros-
taglandin G/H synthase; PGI2, prostacyclin; PGIM, PGI2 metabolite; RCT, randomized
controlled-outcome trial; TARGET, Therapeutic Arthritis Research and Gastrointes-
tinal Event Trial; tNSAID, traditional NSAID; TxA2, thromboxane A2; VIGOR, Vioxx
Gastrointestinal Outcome Research.
Conflict?of?interest: G.A. FitzGerald receives financial support for investigator-initi-
ated research from Bayer, Merck, and Boehringer Ingelheim, all of which manufacture
drugs that target COXs. G.A. FitzGerald is a member of the Steering Committee of the
Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) Study
Program. This author also serves as a consultant for Johnson & Johnson, Bayer,
Merck, GlaxoSmithKline, Novartis, Boehringer Ingelheim, and NiCox.
Citation?for?this?article: J. Clin. Invest. 116:4–15 (2006).
Page 2
science in medicine
?The?Journal?of?Clinical?Investigation http://www.jci.org Volume 116 Number 1 January 2006
months) studies in which endoscopic visualization of drug-induced
ulceration was compared among the coxib, a tNSAID, and placebo.
The superiority of the COX-2 inhibitors over their tNSAID com-
parators in these studies was striking (24–28).
Mechanistic basis for a cardiovascular hazard
resulting from inhibition of COX-2
During the course of drug development, we found that both cele-
coxib and rofecoxib suppressed urinary 2, 3-dinor 6-keto PGF1α, a
stable PGI2 metabolite (PGIM), to a degree
comparable to that attained by treatment
with structurally distinct tNSAIDs (29, 30).
While the latter drugs inhibited platelet
aggregation ex vivo transiently at the time of
peak action, the coxibs had no such effect,
compatible with the absence of COX-2
from mature human platelets (31). Unlike
the tNSAID comparators in these studies
— ibuprofen and indomethacin — neither
celecoxib nor rofecoxib inhibited COX-1–
derived TxA2 coincident with its impact on
PGI2. Thus, the cardiovascular effects of
TxA2 would be expected to be exaggerated.
However, as PGI2 was known to act as a gen-
eral restraint on any recognized stimulus to
platelet activation, it was not suggested that
upsetting a notional "balance" between the 2
prostanoids was likely to be the mechanism
of drug action. Correspondingly, variation
in other endogenous mediators, such as
NO, would be expected to modulate the
impact of COX-2 inhibition on cardiovas-
cular function. Given that similar observa-
tions were made with both celecoxib and
rofecoxib, it appeared that this effect was
mechanism based, rather than an off-target
effect restricted to 1 compound. Despite the
presence of only COX-1 in endothelial cells
under static conditions in vitro (32), PGI2
— a dominant product of endothelium (33)
— appeared largely to derive from COX-2
under physiological conditions in humans.
Prior findings of Topper and Gimbrone
(34) were invoked to explain these observa-
tions. They had found that subjection of
endothelial cells in culture to laminar shear
upregulated COX-2 expression. Thus, induc-
tion of COX-2 was likely to have occurred in
response to blood flow under physiologi-
cal conditions in vivo. Studies that led to
approval of the coxibs were too short and
too small in subject number to have exclud-
ed a risk of myocardial infarction or stroke
attributable to this hypothesis.
Insight into the consequences of suppress-
ing PGI2 in vivo were limited at the time;
deletion of the PGI2 receptor (IP) augmented
the response to an exogenous thrombogenic
stimulus in mice (7). However, it was claimed
that redundancy with other antithrombotic
systems, particularly the elaboration of NO, would annul the impact
of PGI2 suppression in vivo. When deletion of the IP was shown to
restrain the effect of endogenous TxA2 on platelet activation and
vascular proliferation in response to injury (35), it was questioned
whether loss of 2 copies of the IP would mimic the substantial but
incomplete suppression of PGIM attained in humans (S1). Subse-
quent experiments revealed that IP deletion predisposed to thrombo-
sis in a gene dose–dependent fashion; the effect of a COX-2 inhibitor
in thrombosis models was intermediate between IP+/– and IP–/– mice
Figure 1
Schematic depiction of the structural differences between the substrate-binding channels of COX-1
and COX-2 that allowed the design of selective inhibitors. The amino acid residues Val434,
Arg513, and Val523 form a side pocket in COX-2 that is absent in COX-1. (A) Nonselective inhibi-
tors have access to the binding channels of both isoforms. (B) The more voluminous residues in
COX-1, Ile434, His513, and Ile532, obstruct access of the bulky side chains of COX-2 inhibitors.
Figure modified with permission from Nature from protein structures reported in refs. 18 and 20.
Page 3
science in medicine
??The?Journal?of?Clinical?Investigation http://www.jci.org Volume 116 Number 1 January 2006
(Y. Cheng, personal communication). It has also been suggested that
the presence of PGIM does not reflect endothelial biosynthesis of
PGI2 and that COX-2 is undetectable in endothelial cells ex vivo (S2).
While one can never attribute with certainty a tissue of origin to a
metabolite measured in urine (36) or plasma (37), studies in vitro had
indicated that endothelium is the major tissue source of PGI2 (33)
and local vascular stimulation and short-term systemic administra-
tion of PGI2 is reflected by readily detectable alterations in urinary
PGIM levels (38, 39). Furthermore, expression of COX-2 is evident
in human endothelial cells ex vivo (Figure 2A), and expression of
endothelial COX-2 may be modulated in a flow-dependent manner
in mice (Figure 2, B–F). Indeed, the human cDNAs for COX-2 were
originally cloned from unstimulated endothelial cells (40, 41), reflec-
tive of constitutive expression of the enzyme. Aside from physiologi-
cal conditions, one would expect that vascular stimulation by the
products of platelet activation and by inflammatory cytokines might
upregulate endothelial and vascular smooth muscle cell expression of
COX-2, as occurs in atherosclerotic lesions (42, 43). Indeed, excretion
of both PGIM and the TxA2 metabolite 2, 3-dinor TxB2, are together
increased in patients with severe atherosclerosis (43, 44, S3). The fail-
ure of some studies to report COX-2 expression in endothelial cells
ex vivo may reflect the particular experimental circumstances and/or
discordance between the offset kinetics of flow-induced gene expres-
sion and the time of sample preparation.
Subsequent work expanded our understanding of the effects of
PGI2 on cardiovascular biology (Figure 3). Celecoxib suppressed
PGI2-dependent vascular bioactivity and undermined the anti-
thrombotic effect of aspirin in dogs (45). Selective COX-2 inhibition
suppressed PGI2 and predisposed to platelet activation and arte-
rial thrombosis under conditions of hypoxia-induced pulmonary
hypertension in rodents (46). Similarly, selective COX-2 inhibition
suppressed PGI2 and enhanced platelet–vessel wall interactions
in vivo and platelet adhesion to hamster cheek pouch arterioles
(47). PGI2 was shown in endothelial cells to stimulate substantially
thrombomodulin (48). Thus, removal of this natural constraint to
thrombin activation would interact with augmented
platelet activation to promote assembly of the pro-
thrombinase complex and consequent thrombosis,
perhaps particularly in the microvasculature. Reper-
fusion injury of the myocardium is augmented in
mice lacking the IP (49), suggesting a limit to the
benefit of such therapeutic strategies in patients who
suffered a thrombosis, and COX-2–dependent PGI2
was shown to afford protection against oxidant inju-
ry to cardiomyocytes in vivo (50).
Aside from effects most relevant to acute human
syndromes of thrombotic vascular occlusion, suppres-
sion of COX-2 may also predispose to a more gradual
elevation of cardiovascular risk during prolonged dos-
ing with inhibitors. Deletion of the IP was found to
promote initiation and early progression of atheroscle-
rosis in mice genetically predisposed to hyperlipidemia
(51, 52). This appears to reflect removal of a constraint
to the activation of both neutrophils and platelets,
their interaction with the vessel wall, and the resultant
oxidant stress. Additionally, COX-2–dependent PGI2
formation appears to contribute to the atheroprotec-
tion afforded by estrogen and mediated via its ER-α
receptor in vivo (52). Deletion of the IP (53, 54), like
COX-2 inhibition (37), elevates blood pressure (54)
and augments the pressor response to dietary sodium (53, 54). Final-
ly, both deletion of the IP and inhibition of COX-2 modulate vascular
remodeling induced by hemodynamic stress — such as hypertension
— in vivo (55). Additional effects on AA metabolism resulting from
COX-2 inhibition, including a failure to metabolize the vasocon-
strictor 20-hydroxyeicosatetraenoic acid (20-HETE) to a vasodilator
product (56) and augmented metabolism via lipoxygenase and cyto-
chrome P450 enzymes, may impact blood pressure regulation. How-
ever, evidence that such effects contribute to the renovascular effects
of COX-2 inhibitors remains to be provided in vivo. COX-2 is also
the dominant source of PGE2 and PGD2 biosynthesis under physi-
ological conditions in humans (S4, S5). Deletion of the EP2 receptor
for PGE2, like deletion of the IP, results in salt-sensitive hypertension
(57), and both PGE2 (via the IP) and PGD2 inhibit platelet activation,
at least in vitro (S6, S7). The extent to which inhibition of these other
PGs might contribute to a cardiovascular hazard of COX-2 inhibitors
remains to be established. In the interim, one might speculate how
the disparate effects of PGI2 suppression on atherogenesis, blood
pressure, and the remodeling response might converge, over time, to
result in transformation of cardiovascular risk in patients initially at
low risk when exposed to chronic COX-2 inhibition (58).
In summary, a substantial body of evidence has accumulated
that 1 mechanism, suppression of COX-2–dependent PGI2 forma-
tion, can both augment the response to thrombotic and hyperten-
sive stimuli and initiate and accelerate atherogenesis.
Concordance of clinical experience
with mechanism-based predictions
Given the assumption that this mechanism explains the observed
cardiovascular complications of COX-2 inhibitors, how would
such a hazard be expected to become clinically manifest?
First, the actual degree of selectivity attained at the vascular inter-
face in vivo would be an important variable. Although assays in
whole blood in vitro suggest a clear segregation between the degree
of selectivity attained by the drugs under consideration, there are
Figure 2
Expression of COX-2 mRNA in the endothelium (arrows) of human (A) and COX-2
protein in murine (B–E) arteries. (A) In situ detection of COX-2 mRNA in the endothe-
lium of a human umbilical artery. Image kindly provided by James N. Topper, Frazier
Healthcare Ventures, Palo Alto, California, USA. (B–E) Immunostaining shows COX-2
upregulation 4 weeks after left common carotid artery ligation in mice. Scale bars: 50 µm.
Baseline COX-2 expression (brown staining) is evident in the intima in cross sections
of the right common, unligated carotid artery, which served as a control. Magnifica-
tion, ×20 (B); ×40 (C). Flow reduction induced further COX-2 expression in the intimal
layer and marked endothelial expression as shown in D and E. Magnification, ×20
(D); ×40 (E). LC, left common carotid artery; RC, right common carotid artery. B–E
are reproduced here with permission from Circulation Research (55).
Page 4
science in medicine
?The?Journal?of?Clinical?Investigation http://www.jci.org Volume 116 Number 1 January 2006
substantial interindividual differences in drug response (59) and
consequent overlap in the degree of selectivity attained in vivo. Selec-
tivity for COX-2 can be viewed as a continuous variable within the
class of NSAIDs. Indeed, some tNSAIDs — diclofenac, nimesulide,
meloxicam, and nabumetone — express average selectivity for COX-2
similar to that of celecoxib in human whole blood in vitro (28).
Sufficient concentration of any selective COX-2 inhibitor becomes
nonselective as it begins to inhibit COX-1, at least in vitro (28, 60).
Second, the more prolonged the drug exposure (determined by dose,
duration of action, and duration of treatment), the more likely an
Figure 3
Roles of the COX isozymes in cardiovascular (A and C) and renal (B) biology. ACE, angiotensin-converting enzyme; ADP, adenosine
diphosphate; aPC, activated protein C; BK, bradykinin; ecNOS, endothelial cell NOS; MBF, medullary blood flow; RAS, renin-angiotensin
system; TM, thrombomodulin.
Page 5
science in medicine
??The?Journal?of?Clinical?Investigation http://www.jci.org Volume 116 Number 1 January 2006
adverse consequence. Third, concordant administration of low-dose
aspirin, which favors inhibition of COX-1 (61), would be expected
to mitigate but not abolish the hazard. The degree and duration
of simultaneous inhibition of the 2 COX enzymes would also be
expected to influence the existence of a cardiovascular hazard from
tNSAIDs (see below). Finally, IP–/– mice are more responsive to
thrombogenic stimuli; they do not develop spontaneous throm-
bosis (7). Thus, a clinical or genetic predisposition to thrombosis
would favor emergence of a drug-related cardiovascular event.
Aside from the question posed by clinical pharmacology, the
first evidence consistent with the hypothetical cardiovascular
hazard emerged in the Vioxx Gastrointestinal Outcome Research
(VIGOR) study (62), in which a 2-fold divergence in the incidence
of serious GI adverse events between rofecoxib and the tNSAID
naproxen coincided with a 5-fold divergence in the incidence of
myocardial infarction (20 versus 4 events). This study was conduct-
ed with a high dose (50 mg/day) of rofecoxib in patients in whom
low-dose aspirin was precluded. Most of the patients suffered from
RA, a disease associated with an odds ratio of a myocardial infarc-
tion roughly 50% higher than in patients with osteoarthritis or
no arthritis (63). These results generated considerable controversy;
some researchers claimed that rofecoxib was neutral and that the
result reflected a cardioprotective effect of naproxen, based on its
extended duration of action (64), permitting this mixed inhibitor
of COX-1 and COX-2 to behave like aspirin.
The corresponding outcomes study of celecoxib (Celecoxib
Long-term Arthritis Safety Study [CLASS]) was published in a
highly unorthodox manner (65). Partial presentation of the data
seemed to suggest that high-dose (800 mg/day) celecoxib had
caused fewer GI adverse effects than its tNSAID comparators;
however, this turned out not to be the case when the full data
set was revealed (66). This study, conducted with, on average, a
shorter-lived, less selective COX-2 inhibitor than rofecoxib, also
demonstrated no difference in the incidence of cardiovascular
events. Around 20% of the patients took aspirin, and much was
made of the apparent divergent incidence of GI adverse effects on
ibuprofen versus celecoxib in a post hoc analysis of nonaspirin
users. Perhaps aspirin had masked the GI advantage of celecoxib.
However, if so, it may also have masked the cardiovascular haz-
ard. A similar underpowered and retrospective analysis suggests
that cardiovascular events occurred more often with celecoxib
than with ibuprofen in nonaspirin users. Interestingly, the inci-
dence of both GI and cardiovascular events on diclofenac and
celecoxib appeared to be similar (67).
In summary, the number of events reported in the VIGOR study
was small. However, if the estimate of the difference between the
2 treatment groups was reliable, this was larger than might be
expected from an "aspirin-like" effect of naproxen; clearly it was
Figure ?
Illustration of the expected interaction of baseline cardiovascular and
thrombotic risk with components of drug exposure including dose, dura-
tion of action, and duration of treatment with a selective inhibitor of COX-2.
The approximate relationship of cardiovascular hazard detected in con-
trolled studies within this interaction are indicated (not to scale). APC
study, ref. 81; APPROVe study, ref. 72; CABG studies, parecoxib/valde-
coxib after bypass surgery, refs. 77, 78; VIGOR study, ref. 62.
Figure ?
The spectrum of selectivity for COX inhibition. (A) The relative affinities
of tNSAIDs and coxibs (open circles) for COX-1 and COX-2. The con-
centrations required to inhibit COX-1 and COX-2 by 50% (IC50) have
been measured using whole-blood assays of COX-1 and COX-2 activ-
ity in vitro. The diagonal line indicates equivalent COX-1 and COX-2
inhibition. Drugs plotted below the line (orange) are more potent inhibi-
tors of COX-2 than drugs plotted above the line (green). The distance
to the line is a measure of selectivity. Note the log scale. For example,
lumiracoxib is the compound with the highest degree of selectivity for
COX-2 as its distance to the line is the largest. Celecoxib and diclof-
enac have similar degrees of selectivity for COX-2, as their distances
to the line are similar; however, diclofenac is active at lower concentra-
tions and thus located more to the left. Figure modified with permis-
sion from The New England Journal of Medicine (28). (B) Implication
of the relative degrees of selectivity. Increasing degrees of selectivity
for COX-2 are associated with augmented cardiovascular risk while
increasing degrees of selectivity for COX-1 are associated with aug-
mented GI risk. The relative size of the circles indicates approximately
the variation in sample sizes among the trials.


text:
Category: Soil & Groundwater ×
Subcategory: Geology ×
Keyword: geotechnical ×
Location: Latin America ×
Location: Honduras ×
Geotec Engineering & Environmental Geophysics Ltd
based in rishon letzion, ISRAEL
Geotec Engineering & Environmental Geophysics Ltd. is the leading geophysical services provider in Israel. The company carries out subsurface mapping, imaging and characterization surveys.
Pagani Geotechnical Equipment s.r.l.
based in Calendasco, ITALY
Pagani, world leader in the design and manufacturing of penetrometers for over 30 years, has always been at the leading edge in the technological research. Our philosophy is growing with our customers and providing custom-made services. A constant relationship and cooperation with Universities, Research Institutes and Engineering Companies contribute to the endless ...
Subsurface Geotechnical
based in Worcester, UNITED KINGDOM
Subsurface Geotechnical are a leading firm of independent geophysical consultants based in the heart of the historic city of Worcester. Our geophysical surveys are carried out using a variety of geophysics methods for practical applications in site investigation, geoenvironmental surveys, electrical earthing and non-destructive testing. Established in 1985, our company ...
Art's Manufacturing and Supply, Inc. (AMS Inc.)
based in American Falls, IDAHO (USA)
AMS, Inc. manufactures hand augers, soil probes, core samplers, sludge and sediment samplers, gas vapor probes. AMS PowerProbes can be mounted on pick-up trucks, tracks, or trailers, and have gained widespread acceptance due to their versatility, relatively low cost, and ease of mobility. They are designed to be used for: soil, soil gas, and groundwater sampling and ...
Advanced Terra Testing, Inc.
based in Lakewood, COLORADO (USA)
Advanced Terra Testing, Inc. (ATT) is a full-scope, state-of-the-art geotechnical testing laboratory providing advanced capability in soil & rock mechanics and geosynthetics testing services. Located 20 minutes west of Denver, Colorado in Lakewood, ATT has performed more than 1000 projects for over 400 commercial and governmental clients (including major geotechnical ...
Austhai Geophysical Consultants (Thailand) Co., Lt
based in Bangjak, Prakanong,, THAILAND
The main focus of Austhai Geophysical Consultants / Austhai Geophysics and Geotechnical is on providing expert advice and guidance for geophysical and geotechnical exploration programs being carried out in the mining and metals sector of the materials market as well as the Coal sector of the energy market. Austhai Geophysical Consultants / Austhai Geophysics and ...
Boart Longyear Inc.
based in South Jordan, UTAH (USA)
Boart Longyear offers products to the geo-environmental, mineral exploration and soils and materials testing markets, primarily from its operations in North America. We have serviced the Geotechnical and Environmental markets in North America, South America, Europe and Mexico. Thanks to continued investments in people, manufacturing facilities and product development, ...
based in North Andover, MASSACHUSETTS (USA)
We are the ultimate source for Geotechnical and Hydrogeologic software products. Over 2000 companies, universities and government institutions are using our software products in over 30 countries worldwide.
G.U.B. Ingenieur AG
based in Zwickau, GERMANY
G.U.B. Ingenieur AG. is mainly active in the fields of geotechnical, environmental and construction engineering, including various supplementary services. The operating engineers, scientists and technicians within the G.U.B. Ingenieur AG have many years of professional experience in the fields of geotechnics, geology, hydrology and hydrogeology, environmental engineering, ...
Round Rock Geosciences LLC (RRG)
based in Round Rock, TEXAS (USA)
Round Rock Geophysics offers comprehensive geophysical consulting and survey services to the mineral exploration, civil engineering, geotechnical engineering, groundwater and environmental communities on a worldwide basis. Round Rock Geophysics is one of the fastest growing geophysical consulting firms specialized in providing consulting and contracting services to ...


text:
Madrid Airport Private Arrival Transfer
- Details
- Reviews
- 1 to 3 people transferred in a private car
- 4 to 6 people transferred in a private minivan
When making a booking, you will need to advise your flight details and your Madrid Hotel details. Your transfer will be confirmed instantaneously and you will be provided with a travel voucher to present to the driver.
It's that easy!
Price is per person, based on 6 adults per car/vehicle.
Schedule details
Select a month to view a calendar of availability and departure details.
Pricing information
Click the link below to check pricing & availability on your preferred travel date. Our pricing is constantly updated to ensure you always receive the lowest price possible.
Airport to Madrid (Day)
Code: TFRDAY
Private transfer from Madrid Airport to central Madrid hotels. Flights arriving between 6:01am and 8:45pm
AUD24.59Pricing details
Airport to Madrid (Night)
Code: TFRNT
Private transfer from Madrid Airport to central Madrid hotels. Flights arriving between 8:46pm to 6:00am
AUD24.59Pricing details
Pricing information
Madrid Airport Private Arrival Transfer
- One way private transfer
- Driver/guide
- 1 - 3 people transfer by private car (Mercedes 300 E)
- 4 - 6 people transfer by private minivan (Volkswagen Caravelle)
- Excess luggage charges (where applicable)
- Gratuities (optional)
- Confirmation will be received at time of booking, unless booked within 5 days of travel. In this case confirmation will be received within 48 hours, subject to availability
- The duration of transfers are approximate, the exact duration will depend on the time of day and traffic conditions
- Each traveler is allowed a maximum of 1 suitcase and 1 carry-on bag. Oversized or excessive luggage (e.g. surfboards, golf clubs or bikes) may have certain restrictions, please inquire with the operator prior to travel to confirm if your excess luggage is acceptable
- Adult pricing applies to all travelers
- Price is per person, based on 6 adults per car/vehicle
Traveler Reviews
Reviewed by: jose, October 2015
This was a great experience. Getting somewhere you are unfamiliar with and having a friendly person waiting for you at the Airport. I strongly recommend as great service.
Reviewed by: Derek K, September 2015
Driver was waiting for us with a sign and our name on it in the arrivals hall. He spoke English which helps when conversing with him about the sights of the city on the way to the hotel. As with any airport/hotel transfer service, you should confirm your flight information before you arrive in Madrid, to ensure that the transport company has your information on file and will have a driver waiting for you. Once you do, it should be smooth sailing from there. You can always take a taxi when you arrive in Madrid, however, the taxi line had approximately 60-70 people in the queue during the busy travel season. Why wait, when you can have a private driver there to take you immediately to your destination. Also, have either your paper voucher or electronic cell phone voucher handy, just in case. Our driver did not ask to see it, since we responded to the sign he held with our name and I guess he assumed we were the clients he needed to pickup at the airport he confirmed the hotel destination and number of people, so he knew he had the right customers. Would use this service again definitely.


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Salford City Reds: Sean Long says staff are in dark
Assistant coach Sean Long says there has been a lack of communication with staff and players over the financial problems at Salford City Reds.
The future of the Super League club is in doubt after Salford City Council rejected a rescue plan, which would have seen a total of £1.5m invested.
Long told BBC Radio Manchester: "The players are coming to us and you can see they're frustrated and upset.
"We're in the dark as much as anyone. Someone needs to come out and speak."
"The most important thing is that the future of Salford City Reds is secured. Clearly the move to a new stadium has not worked out. The reasons why are issues that need to be addressed in the future, while the lack of communication from the club is very worrying. But the immediate priority must be to reach a deal that ensures Salford can start the next Super League season. The current board have got to make decisions that are in the best interests of the club and everyone connected with it. Following on from the problems at Bradford Bulls, maybe the whole financial structure of Super League needs reviewing. How many more clubs have to endure serious financial difficulties before the game's governing body realises there are major flaws in the system?"
The former Great Britain international continued: "We're trying to put their minds at ease and tell them what we know, but we know nothing. It's really difficult for us."
The council are already owed £1.5m by the Reds and the proposal to loan another £750,000 was put forward on Tuesday, but it was rejected because the local authority was unhappy with the level of risk involved.
Had the bailout package been approved, that £750,000 figure would have been matched by Peel Holdings, the co-owners of their Salford City Stadium home.
The loan would have been in place until November 2013, with the council and Peel taking over the running of the club.
Salford mayor Ian Stewart told BBC Radio Manchester that the decision was made "with a heavy heart" and said he hoped the club's supporters would have an influence on helping the Reds through their current financial difficulties.
"I really think that if there is to be a future for this club, the fans must be involved in that future and in a better way than they have been in the past," said Stewart.
Salford are currently the subject of a winding-up petition, with a hearing scheduled for 7 January.
It was initially brought by club sponsors Steuer Gregsson in October, and although a settlement with them was agreed, two former players - Luke Patten and Vinnie Anderson - and Revenue & Customs joined the petition.
In a statement, the Rugby Football League said: "The RFL is disappointed that the discussions to transfer the ownership of Salford City Reds to new owners have broken down.
Salford players on Twitter
Stephen Wild: "Last to know anything AGAIN."
Jodie Broughton: "Gonna put the Christmas tree up!!! Heard enough bad news today!"
Jordan James: "Well I hope someone with money comes in to help our club. Don't fancy the dole queue just yet!"
Matty Ashurst: "#nightmare"
"The RFL is currently in talks with all relevant parties and remains confident that a positive solution can be reached."
Ever since Salford's move to their new stadium at the start of the 2012 season, chairman John Wilkinson has appealed for fresh investment, but has frequently denied that the club have been on the verge of administration.
But there has been no comment from any senior figures at Salford City Reds since Tuesday's announcement was made.
The financial uncertainty has severely affected Salford's preparations for the 2013 Super League season, with coach Phil Veivers only able to add one new player - St Helens forward Andrew Dixon - to his squad since the end of the campaign.
Long added: "We found out last night [Tuesday] that the council aren't helping us out, so we're in limbo.
"We're waiting for the green light to go out and sign some players, otherwise we'll just crack on with the job and do the best we can for Salford City Reds, like we've done for the last eight weeks."


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The 14th Street location of sandwich shop Taylor Gourmet is aiming for a Jan. 3 opening.
It's the fourth hoagie shop from Philly natives Casey Patten and David Mazza. The pair is planning another Taylor for Merrifield, as well as a cheese steak place on H Street NE.
The 1908 14th St. location will provide delivery to Columbia Heights and Dupont Circle and be open till 2:30 a.m. on Thursdays and 3:30 a.m. on the weekends.
Long-distance travel inspired this fashion show where an entire airport was recreated.


text: Clinical Research Associate New York - NY Apply View All Jobs Share This Job Job Description ConsignMed, a Niche Clinical Staffing Company since 2003, and rated by Diversity Business as one of the fastest growing companies in the US is seeking a Clinical Research Associate. Skills & Requirements Our Client, a Pharmaceutical Company, is seeking a Regional CRA (home based) for the North East Region. Candidate must have at least 2 years of Site Monitoring experience. Travel with be up to 70%. Must have at least a Bachelor's Degree. Great benefits package! Apply View All Jobs


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Helping Others Gets Contestant Eliminated on 'Top Chef Masters' (VIDEO)
On 'Top Chef Masters' (Wed., 10PM ET on BRAVO), the cheftestants learned that sometimes, timing is everything. The challenge was to take some classic dishes from the 1960s, give them a modern twist and serve them as appetizers to 'Mad Men's' Christina Hendricks and husband Geoffrey Arend (who both admitted to hating '60s food). Everyone crowded into the kitchen. There were some successful ef...
Adam Is Ousted from 'The Real World' Las Vegas (VIDEO)
Adam Royer's violence finally got him thrown out of Las Vegas' Hard Rock Hotel on 'The Real World' (Wed., 10PM ET on MTV). Punching the walls in last week's episode, lashing out at Nany Gonzalez and generally making an ass of himself was too much for his penthouse suite mates and hotel security. The security manager appeared and ordered him to pack up his stuff and leave. Though Adam's been a t...
Courteney Cox Shares St. Barts Photos; Letterman Shares Her Nip-Slip Pic (VIDEO)
On a recent trip to St. Barts, Courteney Cox discovered the paparazzi out in full force. "It became a joke, like, alright let's see how 'Sports Illustrated' we can get," she recalled on 'Late Show' (weeknights, 11:35PM ET on CBS). Lounging on the beach and playing in the surf, she posed for the photographers and "was workin' it pretty hard ... I sucked it in ... My arms are stretched out. I don...
'Deadliest Catch' Crew Spreads Captain Phil Harris's Ashes at Sea (VIDEO)
Before the start of the new fishing season on 'Deadliest Catch' (Tue., 9PM ET on DSC), there's an important ceremony to attend: a burial service for Captain Phil Harris, who died of a stroke last season. His son Josh says Phil wanted his ashes spread at sea: "The tides will carry him wherever he wanted to go." On the season 7 premiere, all the boats gather in a circle. After his ashes are la...
Sinbad Gives Confusing Dating Advice on 'Sinbad: It's Just Family' (VIDEO)
In the season premiere of 'Sinbad: It's Just Family' (Tue., 10PM ET on WE), the standup comic joins his former ex-wife (they remarried eight years ago) and two adult children to live under the same roof for the first time in years. His son Royce needs some dating advice. Sinbad launches in: "Sometimes you need some crazy women in your life to know a good woman." He says men have a different per...
Christian Slater Recalls a Frank Sinatra Concert with 'Goodfellas-Type Guys' (VIDEO)
Christian Slater counts himself lucky to have seen Frank Sinatra in concert. About 20 years ago, he sat in an audience of "'Goodfellas'-type guys" in a huge Las Vegas dining hall. The guys seated around him were friendly, one telling Slater that he used to be a Golden Gloves boxing champion. As Sinatra began to perform, the ex-boxer "starts singing along with him," Slater recounted on 'Lopez...
'Biggest Loser: Couples': Cara Lashes Out When Ken Questions Her Technique (VIDEO)
Among the many lessons learned on 'The Biggest Loser: Couples' (Tue., 8PM ET on NBC), one takeaway is that Cara is more sensitive than one might expect. Ken tells her, "I need more guidance from you on what I should be doing, even with a couple of the injuries I have." She responds defensively, "I've done nothing but work with you since day one ... I'm working around your injuries." He says, "I...
Edge, WWE Champ, Retires Due to Neck Injury (VIDEO)
The WWE's Edge (Adam Copeland) had a big announcement to make on 'Monday Night Raw' (Mon., 9PM ET on USA). "Eight years ago, I broke my neck," he told the crowd. Recently he'd been suffering through a lot of pain and losing feeling in his arms. He was told to get some tests done, and "thankfully I did, because the MRIs showed that, uh, I have to retire," he announced sadly. "The doctors have to...
'Joy Behar Show' Holds Partial 'Family Ties' Reunion (VIDEO)
In case any of us '80s kids were not glued to 'The Joy Behar Show' (weeknights, 10PM ET on HLN), here's a clip from her interview with our beloved 'Family Ties' stars (minus Mallory's Justine Bateman and Alex P. Keaton's Michael J. Fox). Michael Gross (father Steven) and Tina Yothers (Jennifer) joined her in the studio, Meredith Baxter (Elyse) and Brian Bonsall (Andy) by satellite. Joy Be...
O.C. 'Housewives': Does Gretchen Want Marriage After Her Parents Renew Their Vows? (VIDEO)
On 'The Real Housewives of Orange County' (Sun., 10PM ET on BRVO), Gretchen Rossi has been planning a party for her parents' 40th wedding anniversary for weeks. Finally the day has arrived. The high point of the festivities is a vow renewal; Gretchen has even found the pastor who married them four decades ago. "I do hope that Gretchen looking at her mom and dad renew their vows helped ease s...
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Welcome home to an apartment community located in the heart of Austin. Our affordable,1 and 2 bedroom apartment homes are located within minutes of highway 183, 290 and Mopac. Our lush residential setting offers the finest shops, countless restaurants and Austin nightlife right at your fingertips. We're also located within minutes of Mueller Shopping Center and Austin Bergstrom Airport! Time is valuable, location is everything! Come home to a peaceful sanctuary and discover the tranquility you deserve.
$300 one time, non-refundable fee, per pet
$10 monthly pet rent, per pet
Cats Allowed. Dogs Allowed. Call for service animal policy.
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America has proven itself to be harmful to any mideast peace process. Having promised eternal fealty to one of the parties, as well as having supplied them with money, weapons, and political support, calls into question America's role as a fair broker. Israel has repeatedly chosen expansion outside their borders in preference to peace. America has always supported this. This must change before there can be peace. America must be dealt out. Only the UN can do this.
from the article: 'Obama trying to head off trainwreck at UN in September'


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From boycotts to strikes, activism drives social, political and environmental change around the world.
About StumbleDNA StumbleDNA
Isabel Ortiz's Interests
Explore the biology and physiology of the human body. Like Grey's Anatomy, minus the love triangles.
From baby animals to wild creatures to exotic pets, discover cute pictures and more about animals.
From Disney to Flash, the art of animation has brought our favorite cartoons to the screen.
Flex your creativity by exploring performing arts, literature, music, visual arts and more.
What's your sign? Explore astrology and soon you'll be looking to the stars for your horoscope.
Think ordinary is boring? Explore the weird, the strange, the obscure, and the downright freaky.
Are you a bookworm? Do you dream of a Pulitzer? Explore the literature of your favorite authors.
Get into the weeds and explore the science of botany, from plant genetics to the food chain.
Learn about brain disorders and the symptoms of neurological, psychological and nervous system diseases.
What's your five-year plan? Figure it out with career planning tests, interview advice, resume tips and more.
Miss Saturday morning cartoons? Get your dose of cartoons - funny, political and more - here.
With order comes disorder. Learn about chaos theory, controlled chaos and the butterfly effect.
Whether you like romantic comedies or black comedies, have a laugh by Stumbling through funny films.
Where would movies or video games be without computer graphics? Learn about animation, modeling and more.
Culture means something different to everyone. Learn about ethnicity, race, nationality and more.
Explore the art of design, from graphic design on the Web to interior design in the home.
Love mixes and mashups? Learn more about the top DJs and the best house and club music.
No more stick figures! Uncover your inner artist and the world of sketching, charcoals and pastels.
Learn the facts about prescription drugs, medications, supplements and vitamins for a healthier lifestyle.


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Feds to Hold Hearing on Fiat Chrysler Recall Compliance
NHTSA says it will hold a public hearing to determine if Fiat Chrysler failed to notify customers and fix safety problems in more than 10 million vehicles.
NHTSA says it will hold a public hearing to determine if Fiat Chrysler failed to notify customers and fix safety problems in more than 10 million vehicles.
The average price of a gallon of regular-grade gasoline in the U.S. rose 22 cents over the past three weeks to $2.82, according to a Lundberg survey.
From Tesla to Google to BMW to Ford and GM -- suddenly, everyone wants to invent the self-driving car. But will anyone really want to ride in them?
Drivers pay an average of 41 percent more for car insurance after making a single claim, according to the second annual study by insuranceQuotes.com.
Google's newest self-driving car will debut on public roads this summer, as it seeks to have driverless cars available to consumers in the next five years.
Gas prices will be at lowest summertime level since at least 2009 — and possibly the lowest since 2005, when gas averaged $2.33 a gallon May-to-September.
Four of the nearly 50 self-driving cars now rolling around the state of California have gotten into accidents since September.
Driving without a license or not buckling up won't cost you all that much, but the difference between careless and reckless driving could triple your rates.
The jury is out on whether a new device that purportedly allows you to text and drive is good news or another dangerous distraction. See what you think.
GM, Nissan, Tesla and others are bringing more all-electric models to market. But many consumers are still shying away from the technology.
What you need to know about insurance, driver's training, appropriate vehicles and even surveillance of your new driver.
The average price of regular-grade gasoline rose about 5 percent in the past two weeks to $2.58 a gallon, according to the Lundberg survey released Sunday.
Real estate, travelers and the intensity of competition are among the factors for why gas prices vary so much across a metropolitan area.
Motorists made the most of low gasoline prices by driving record miles in the first two months of the year, according to government data released Thursday.
A little strategic research is the key to finding a trustworthy auto professional. Here are some ideas -- and more -- to steer you in the right direction.
The average national price of a regular gallon of gasoline continues to drop, falling 5 cents in the past three weeks to $2.45 a gallon.
When auto companies roll out new cars like they did at last week's New York auto show, the unveilings can sometimes push down the prices of existing models.
The price for gas is forecast to fall 32% from a year ago to $2.45 a gallon from April to September, the period when Americans do most of their driving.
Just as the summer driving season approaches, drivers may soon be paying even less at the pump, with gas prices expected to fall below $2 a gallon.
The average price of regular grade gasoline fell 4 cents in the past two weeks, bringing it to $2.50 a gallon, according to the Lundberg survey.
Fuel demand in Texas is growing strongly as lower oil prices encourage motorists to use their vehicles more and buy larger replacements.
The average price of regular grade gasoline rose 21 cents in the past two weeks, bringing it to $2.54 a gallon, according to a survey released Sunday.
Apple Watch will replace your car keys and its battery will last the whole day, Apple CEO Tim Cook tells a British newspaper.
The average price of a gallon of gas rose 13 cents in the past two weeks, up 26 cents since prices bottomed out after a nine-month slide ended in January.
The average price of a regular gallon of gas jumped 13 cents in the past two weeks to $2.20, ending a sustained drop, according to an industry survey.
For the first time since 2009, most Americans are paying less than $2 a gallon. Just three months ago experts were shocked when it fell under $3.
Driverless cars are predicted to be no more than five years away from showrooms. A university builds a test city for them.
Car buyers are paying the lowest prices in years for carbon-based fuels, even as automakers show off their latest high efficiency vehicles in Detroit.
The average price of a gallon of gasoline fell 27 cents in the past three weeks, falling to its lowest level since April 2009, a new survey shows.
This year promises to provide much bigger savings to consumers as long as crude oil remains relatively cheap, AAA says. Though there are no guarantees.


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confederate flag
Sponsored By
20 Virginia High School Students Suspended For Wearing Confederate Flag ClothingThe Christiansburg High students refused to change clothes after school officials told them they were violating the school's dress code.
Alexandria Council Bans Flying Confederate Flag by CityThe Alexandria City Council has voted to ban the flying of Confederate flags by the city.
Recall of Va. Confederate Flag Plates Meeting ResistanceAttorneys for a Southern heritage group are urging members to resist a recall of Virginia license plates with an image of the Confederate battle flag.
Virginia Revokes License Plates Featuring Confederate FlagVirginia has revoked specialty license plates featuring a Confederate battle flag after a federal judge dissolved an injunction allowing the image.
Judge: Virginia Can Ban Future Confederate License PlatesA federal judge says Virginia can ban the Confederate flag from any specialty license plates the state issues in the future but made no decision on existing tags.
Palin Facebook Post Asks Which Killed 90,000 Black Babies Last Year: Confederate Flag Or Planned ParenthoodFormer Alaska Gov. Sarah Palin is going after Planned Parenthood after two stealthily recorded videos showed officials discussing how they provided aborted fetal organs for research.
President Obama Greeted With Confederate Flags In OklahomaProtesters waved Confederate flags as the president arrived in Oklahoma on Wednesday.
After 54 years, Confederate Flag Removed From S.C. StatehouseThe Confederate flag was lowered from the grounds of the South Carolina Statehouse to the cheers of thousands on Friday.
House Scraps Vote on Confederate Flag in Federal CemeteriesThe Republican-controlled House scrapped a vote on permitting the Confederate flag at Park Service-run cemeteries on Thursday, a retreat under fire that only escalated a ferocious attack by Democrats complaining the banner celebrates a murderous, racist past.
Va. Bid to Banish Confederate Flag from Plates OpposedA Southern heritage group says it is going to federal court to keep the Confederate battle flag on Virginia license plates.
S.C. Governor: Confederate Flag Comes Down FridaySouth Carolina Gov. Nikki Haley signed a bill into law Thursday that will bring down the Confederate flag outside the Statehouse, a move that seemed unthinkable only a month ago in this Deep South state that was the first to secede from the Union.
Md. Governor Favors Recall of Confederate License PlatesMaryland Gov. Larry Hogan said Thursday that he supports taking some steps to address concerns over the Confederate flag and whether it is a historic symbol or racist reminder, but extreme measures only represented "political correctness run amok."


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Medicare Physician Services:
Use of Services Increasing Nationwide and Relatively Few Beneficiaries Report Major Access Problems
GAO-06-704: Published: Jul 21, 2006. Publicly Released: Jul 21, 2006.
Additional Materials:
- Highlights Page:
- Full Report:
- Accessible Text:
(202) 512-3000
Office of Public Affairs
(202) 512-4800
Congress, policy analysts, and groups representing physicians have periodically raised concerns that Medicare's efforts to control spending on physician services by limiting annual updates to physician fees could have an adverse impact on beneficiaries' access to physician services. These concerns were heightened in 2002 when Medicare's formula for setting physician fees required a 5.4 percent reduction in fees to help moderate rapid spending increases. From 2003 to 2006, fees have not grown as rapidly as the estimated cost to physicians of providing services, and concerns about access have remained. The Medicare Prescription Drug, Improvement, and Modernization Act of 2003 requires GAO to study access to physician services by beneficiaries in the traditional fee-for-service (FFS) program. This report focuses on (1) trends and patterns in beneficiaries' perceptions of the availability of physician services from 2000 through 2004, (2) trends in beneficiaries' utilization of physician services from 2000 through 2005, and (3) indicators of physician supply and willingness to serve Medicare beneficiaries from 2000 through 2005. GAO analyzed the most recent data available, including several years of data from an annual survey of FFS Medicare beneficiaries as well as utilization trends based on all Medicare physician claims for services provided in April of each year from 2000 through 2005.
From 2000 through 2004, among beneficiaries who needed access to physician services, the percentages reporting major difficulties--that is, "having a big problem" finding a personal provider or specialist or never being able to schedule an appointment promptly--remained relatively constant. Nationwide, no more than about 7 percent of beneficiaries reported a major access difficulty. We identified certain beneficiary characteristics--including health status, age, and race--that were associated with beneficiaries' reporting major access difficulties. In general, from April 2000 to April 2005, an increasing proportion of beneficiaries received physician services and an increasing number of physician services were provided to beneficiaries who were treated. This trend was evident in every state's urban areas and nearly every state's rural areas. Two other access related indicators--the number of physicians billing Medicare for services and the proportion of services for which Medicare's fees were accepted as payment in full--increased from April 2000 to April 2005. These increases suggest that there was no reduction in the predominant tendency of physicians to accept Medicare patients and payments. The increases in utilization and complexity of services GAO observed demonstrate that beneficiaries were able to access physician services. However, GAO did not determine the medical appropriateness of these increases. Although access to appropriate care is important, the implications of these trends in utilization for the long-term fiscal sustainability of the Medicare program would require careful examination. CMS agreed with GAO's findings and conclusions, stating that the analysis was well-conceived and executed. CMS also provided technical comments, which GAO incorporated as appropriate.
Oct 9, 2015
Chemicals Management:Observations on Human Health Risk Assessment and Management by Selected Foreign ProgramsGAO-16-111R: Published: Oct 9, 2015. Publicly Released: Oct 9, 2015.
Oct 1, 2015
Hospital Value-Based Purchasing:Initial Results Show Modest Effects on Medicare Payments and No Apparent Change in Quality-of-Care TrendsGAO-16-9: Published: Oct 1, 2015. Publicly Released: Oct 1, 2015.
Sep 30, 2015
Medicare:Considerations for Expansion of the Appropriate Use Criteria ProgramGAO-15-816: Published: Sep 30, 2015. Publicly Released: Sep 30, 2015.
Sep 28, 2015
Medicare Advantage:Actions Needed to Enhance CMS Oversight of Provider Network AdequacyGAO-15-710: Published: Aug 31, 2015. Publicly Released: Sep 28, 2015.
Sep 14, 2015
Medicare Part D:Changes Needed to Improve CMS's Recovery Audit Program Operations and Contractor OversightGAO-15-633: Published: Aug 14, 2015. Publicly Released: Sep 14, 2015.
Sep 10, 2015
Defense Health Care Reform:Actions Needed to Help Ensure Defense Health Agency Maintains Implementation ProgressGAO-15-759: Published: Sep 10, 2015. Publicly Released: Sep 10, 2015.
Sep 9, 2015
Private Health Insurance:The Range of Premiums and Plan Availability for Individuals in 2014 and 2015GAO-15-687: Published: Aug 10, 2015. Publicly Released: Sep 9, 2015.
Aug 10, 2015
Medicaid:Additional Reporting May Help CMS Oversee Prescription-Drug Fraud ControlsGAO-15-390: Published: Jul 8, 2015. Publicly Released: Aug 10, 2015.
Jul 30, 2015
Medicaid:Key Issues Facing the ProgramGAO-15-677: Published: Jul 30, 2015. Publicly Released: Jul 30, 2015.
Federal Autism Research:Updated Information on Funding from Fiscal Years 2008 through 2012GAO-15-583R: Published: Jun 30, 2015. Publicly Released: Jul 30, 2015.
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Craftsy Member since October 2011
I'm enrolled in these Craftsy classes:
The Free-Motion Effect: Designing Custom Quilting
Quilting With Rulers on a Home Machine
Knit Original Cuff-Down Socks
Raising the Bar: Quilting Linear Spaces
Drawing With Colored Pencils
Silhouette Savvy
The Machine Embroidered Sweater
Mastering Construction: Foundation Techniques
Button Bands & Buttonholes
Low & Slow BBQ at Home
Creative Quilting with Your Walking Foot
Continuous Line Quilting
Pain-Free Foundation Piecing
Help! How Do I Quilt It?
Start Machine Quilting
A New Look at Longarm Quilting
Foundations of Double Knitting
Sew Sturdy Travel Organizers
Knitting With Beads
Machine Quilting Beautiful Borders
Seaming Handknits
Sewing Custom Valances
Start Free-Motion Quilting
Ins & Outs of Grafting
Hand-Stitched Collage Quilts
Quilt-As-You-Go Patchwork Bags
Mastering Zipper Techniques
Sewing Designer Jeans
Spinning Dyed Fibers
Improve Your Knitting
2014 Block of the Month: Craftsy Color Theory
Finishing School: Edges & Bindings
Dot-to-Dot Quilting
Re-Piecing the Past
Patternmaking Basics: The Bodice Sloper
Machine Quilting with Templates
Color Play for Quilters
Stitch & Slash
Craftsy Block of the Month 2013
Fast-Track Fitting
Decorative Seams
Free Motion Fillers, Vol. 1
Sew Better, Sew Faster
Creative Serging
Free-Motion Machine Embroidery
The Machine Embroidered T-Shirt
Quilting Quickly II
Linear Landscape Quilts
Big Techniques from Small Scraps
Machine Embroidery, Hand-Stitched Looks
Free Motion Quilting a Sampler
Micro Torch Basics
Design It, Quilt It
Machine Quilting Negative Space
The Art of Cloth Dyeing
Thread Art
Know Your Wool
Short Rows
Beyond Basic Machine Quilting
Quilting Big Projects on a Small Machine
Stupendous Stitching
Pictorial Quilting Techniques
Machine Quilting
Fit Your Knits
Craftsy Block of the Month 2012
Drab To Fab Furniture Upcycling
Free Motion Fillers, Vol. 2
Creative Quilt Backs
Sew the Perfect Fit
Design Your Own Handbag
Free-Motion Quilting with Feathers
Torch-Fired Precious Metal Clay
Making Leather Bags
Wire-Wrapped Stones, Crystals & Clusters
40 Ways to Cast On & Bind Off
Pictures to Pixel Quilts
Vegetable Gardening: Innovative Small-Space Solutions
Patternmaking + Design: Creative Darts & Seam Lines
Adjust the Bust
Machine Quilting Wholecloth Quilts
Dimensional Machine Embroidery
Machine Embroidery With Terrycloth and More
Finishing School: Better Borders
Knit Original Toe-Up Socks
Fun Techniques With Fabric Paints
Magical Jelly Roll Quilts
The Secrets of Free-Motion Quilting
Garden of Quilted Possibilities
Sewing Knits That Fit
Ultimate Free-Motion Quilting
Sew Better, Sew Faster: Advanced Industry Techniques
Custom Fitting: Back, Neck, and Shoulders
Machine Embroidery With Knits
The Essential Guide to Finishing Handknits
Drafting From Worsted to Woolen
Fast-Track Fitting: In the Details
Machine Quilting: Small Changes, Big Variety