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Select Local Merchants
Lube StopRead MoreLube Stop has been lauded by both local and national press outlets for its Sustainability Program, which decreases the environmental impact of the shop's auto services. Its signature EcoGuard oil change, for example, refreshes engines with re-refined motor oil. Lube Stop also recycles oil and antifreeze, and it plants two new oil-filter trees for every one it chops down. Besides eight kinds of oil changes, Lube Stop provides multipoint inspections, tire rotations, wiper blade replacement, and other maintenance and repair services. More than 240 employees—who receive continuous training to keep up with eco-friendly practices—helm the company's 37 Cleveland- and Akron-area locations, all of which offer E-Check emissions-testing stations.3106 Whipple Ave. NWCanton, OH US
Downtown Ford Lincoln MercuryRead MoreWhen it's time to get a new car, check out the cars on display at Downtown Ford Lincoln Mercury's dealership in Canton. Ensure your vehicle's system get the maintenance it needs with a quality oil change. Additionally, you'll want to make sure your tires are in tiptop shape. Downtown Ford Lincoln Mercury offers great tire changes and rotations, too. Make sure your car looks as great as it did the day you drove it off the lot by inquiring about Downtown Ford Lincoln Mercury's excellent dent and scratch repair service. Everyone deserves to treat themselves every once in a while so make your way over to Downtown Ford Lincoln Mercury and check out the latest vehicles. So keep your car looking and running smoothly all year long with some affordable and highly rated services from Downtown Ford Lincoln Mercury. For a job well done, there's simply no better place to go than Downtown Ford Lincoln Mercury's auto shop in Canton.1423 Tuscarawas Street WestCanton, OH US
Waynesburg Carriage CompanyRead MoreNext time you're in need for a car, you'll want to browse the selection at Waynesburg Carriage Company's one-of-a-kind dealership in Waynesburg. Great news! Whenever you come to Waynesburg Carriage Company for service on your car, they can help you with an oil change, too. Make sure your car looks as great as it did the day you drove it off the lot by inquiring about Waynesburg Carriage Company's excellent dent and scratch repair service. Don't ration your car's maintenance, especially when Waynesburg Carriage Company offers conveniently priced tire changes as well. So when you are ready to make a change, head over to Waynesburg Carriage Company and treat yourself to a hot new ride. Waynesburg Carriage Company's automotive shop is ready for your business today in Waynesburg with their convenient scheduling and right pricing for you and your car.173 Mill StreetWaynesburg, OH US
Hills and Dales AutocareRead MoreTake pride in your car's appearance by using the excellent staff at Hills and Dales Autocare's body shop in Canton. When you need service for your vehicle's tires, take advantage of Hills and Dales Autocare 's reliable tire change and rotation services. Hills and Dales Autocare truly has all the car services you need, including a fluid replacement for your transmission. Keep your engine healthy with a quality oil change from this bar. You'll be happy to know that Hills and Dales Autocare can attend to any scratches and dents on your vehicle as well. When your ride needs some body work done, make your way over to Hills and Dales Autocare and check out your options. You'll thank Hills and Dales Autocare for its quality automotive repair shop in Canton for their tremendous helpfulness and willingness to save you money where it counts.4500 Hills And Dales Rd NWCanton, OH US
Buck ChevroletRead MoreWhen it's time to update your rig, check out the wide variety of options available at Buck Chevrolet in Canal Fulton (other dealerships don't even come close to competing). Here you can change and rotate your tires in a jiffy, allowing you to get back on the road in no time. Be proactive about your car's blemishes by calling upon Buck Chevrolet to get rid of them today. While you're stopping by Buck Chevrolet, it'll probably be a good idea to get an oil change, too. So if you're on the market for a brand new whip, head on over to Buck Chevrolet and check out the latest vehicle inventory. When it comes to automotive repairs, you can count on the professional staff at Buck Chevrolet to get your ride back in good shape. So head on over to Buck Chevrolet, where you'll find quality auto care and service you can depend on.321 S Canal StCanal Fulton, OH US
Kenworth of CantonRead MoreDrive off the lot with a beautiful car and a great bargain when you shop the dealership at Kenworth in Canton. Is it time for your car's oil change? Their well-trained technicians work to ensure you'll be in an out in no time with a smooth-running engine. If you are making a big move, make sure you stop by here for a tire change and rotation before you hit the road. Make your friends think you got a new car when you get rid of those dents and scratches using Kenworth's repair service. Whether you need a new car for yourself or for your family, Kenworth has the best selection of rides in town. When you need a quick and affordable solution to your vehicle damages, pay Kenworth a visit. A sick car prevents you from moving at the pace of your life. For any automotive needs, test Kenworth's crew in Canton.3350 Bruening Ave SWCanton, OH US


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Property to let in Dorlan Avenue, Manchester M18
Keywords and filters like garden and parking live here
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£800 pcm (£185 pw)
Dorlan Avenue, Manchester M18Semi-detached house to rent - 4 bedrooms
*spacious extended four bed semi, with parking & gardens* Sanderson James are proud to bring to the market this charming part furnished three bedroom semi detached. Briefly the property comprises of a welcoming hallway which leads through to the ... More details
Note: Distances are straight line measurements
- Reddish North (0.7 miles)
- Ryder Brow (0.9 miles)
Marketed by Sanderson James, M18. Call 0161 937 6480

subset: commoncrawl


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I am looking to get a new wireless computer for a new bike and stumbled upon the garmin edge 200 which can be had for around $125 which is more than I planned to pay for a computer. But for a gps, that seems reasonable. The thing I like about the edge is that it has a breadcrumb feature that helps you backtrack in case you get lost (which I am prone to doing). Another option is an iphone app that would offer the same type stuff. For those that use apps, will they work if you are out of range and don't have phone service? How do you like what you are using? Thanks for any opinions.
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Thread: Garmin edge 200 vs. iphone app
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Watch Friday Night Lights Season 3 Episode 6 online via TV Fanatic with over 4 options to watch the Friday Night Lights S3E6 full episode. Affiliates with free and paid streaming include Amazon, iTunes, Vudu, and Google Play.
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J.D. McCoy continues his rise to Dillon stardom, while Matt rekindles his romance with Julie.
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Wolverhampton Graduation Ceremony!
Congratulations to all of our degree students!
It gives The Academy great pleasure to see so many of our talented musicians receiving their hard earned degrees at Monday's graduation at Wolverhampton University. Congratulations to them all and also to our Academy staff and tutors who have mentored these students throughout their Academy journey.
Steve Ryan
The Academy of Music and Sound
Glasgow Graduation Ceremony!
It gives The Academy of Music and Sound great pleasure to see so many of our talented musicians receiving their hard earned degrees!
Congratulations to all our hard working students and staff who have achieved such excellent results in the run up to this graduation..our centres in Edinburgh, Glasgow and Gateshead should be rightly proud of their skill, talent and hard work. Well done everybody!
Steve Ryan
The Academy of Music and Sound
The Business of… Songwriting. Chaired by our Academy of Music and Sound's North East Manager Dan Donnelly
The UK's Leading music development agency, catering for wider creative industries. Wednesday 23rd September 6.00pm The Core, Science Central, Newcastle.
Next up in Generator's series 'The Business of…' we focus on Songwriting and the business behind it. Joining us to offer practical advice and first-hand experiences are songwriter manager, Will Frank (SBW Music) who represents Ivor Novello and Grammy winning songwriter Cathy Dennis among others and Rebecca Jones known for her collaborations with Groove Armada and her own work as Saint Saviour. Chairing the discussion and asking the all important questions is singer-songwriter Dan Donnelly who is also a member of The Wonder Stuff.
'The Business of… Music Production' Highlights
Last night we took an enlightening look at the world of Music Production. Joining us for a thoroughly engaging discussion were producers Rob Ellis (PJ Harvey, Anna Calvi, Bat for Lashes), Matthew Johnson (Hookworms, Frankie & The Heartstrings, Joanna Gruesome) and Andrew Archer (Trafik).
With a mixture of anecdotes and informative information, the trio, whose experience of the industry varied and covered all levels and many genres, helped attendees grasp the role of a modern producer and how to earn income from the craft.
Here's 5 golden nuggets that came out of the discussion:
Remember you're working for the band on their record, offer advice and guidance but don't impose your ideas.
There's more to the role than purely the creative skills, to be efficient you need to learn about project management. You also need people skills and on occasion, be a mediator during band squabbles.
As a producer, if you play on a recording or are named as 'eligible studio producer', make sure you register with PPL to generate revenue from airplay and public performances of the record. Forms can be found on the PPL website –
Remixing is becoming an increasingly valuable revenue stream and can generate leads for future work and creative collaborations.
It shouldn't be all about making money, remember why you got into music and do it because you have a passion for it.
Visit the website –
With Love From Liverpool, Syria Refugee Fundraiser
Saturday the 19th September at the Echo Arena in Liverpool
A massive fundraising concert hosted by award-winning British comic, John Bishop, is to be held at Echo Arena on Saturday 19 September, 2015.
Leaders, musicians and businesses alike from across the city have rallied together to host this one-off concert in an urgent bid to support the desperate plight of thousands of refugee families fleeing from war. All profits will be donated to British Red Cross.
The current musical line-up includes The Farm, OMD (Orchestral Manoeuvres in the Dark), John Power, Mic Lowry, The Christians and members of CAST, Space, The Icicle Works and Sense of Sound. Further artists are to be confirmed in the coming days.
John Bishop, the much-loved Liverpool comedian, will be hosting the concert alongside legendary BBC Radio 2 broadcaster, Janice Long.
Janice Long said:
"I've been blown away by my hometown's reaction to this crisis. People across Liverpool have shown that they really care in hundreds of different ways, and they've come together to do what they can to ease this terrible situation. It's great to see the music industry coming out in force to do what they do best; put on a great show and raise as much money as we can. It's great to see so many brilliant bands adding their names to what is an incredible line-up of talent.
"I can't wait to stand on the stage, looking out at an arena full of generous people who really care about what is going in the world and who will have a great time raising money for this important cause. We need as many people as possible to buy tickets – I know it's going to be a night to remember!"
Peter Hooton, lead singer of The Farm, said
"When we were approached to perform at the concert, we immediately said 'yes' – it was a no-brainer, no matter how short the notice was. We've all been moved by what is a humanitarian crisis and we've all got a role to play in supporting those in need. I just know Liverpool and its people will come out in force to support this concert – it's what we do, it's who we are."
Liverpool set the example for the rest of the country just last week when Mayor Joe Anderson made national news by becoming the first UK Mayor to actively offer to house refugees in the city.
Joe Anderson, Mayor of Liverpool, said:
"Liverpool's response to last week's horrifying revelations surrounding the ongoing refugee crisis has been nothing short of overwhelming. When it comes to reaching out and offering solidarity to the families whose homes have been ripped away from them, Liverpool is leading the way. Now, Liverpool is stepping up to the plate once more with the 'With Love From Liverpool' concert. We're using our reputation for world-class music to now help save lives across the globe."
All proceeds from the 'With Love From Liverpool' concert will be made to British Red Cross, who are carrying out crucial work across the continent. Their activities include giving food, water and medical aid to refugees arriving in the continent and ensuring that families stay together throughout the long and gruelling journey. They are also working with search and rescue teams in Italy, saving families from drowning during the perilous crossing.
Tina Robinson, senior community fundraiser for Merseyside, said:
"The surge in awareness and support over the past week has been astounding, and I'm grateful that so many people have finally realised the extent of the grave situation. These people aren't coming to Europe for a 'better life', but simply to stay alive. They are refugees, fleeing from war.
The work that we're carrying out is varied and addresses a number of critical issues. In addition to providing on-the-spot immediate aid, we're also guiding refugees through the asylum process, making sure that families stay together and that children don't get separated from their parents during the chaotic journey across the continent."
Under 14s must be accompanied by an adult
Line up subject to change
To find out more see –
We look forward to our first Scottish Graduation next week!
Student's from our Gateshead, Glasgow and Edinburgh Centre's to Graduate next week!
We have selected graduates for our first ever awards and they will be handed out at graduation next week!
This year we have:
· 81 students graduating from the BA (Hons)Performance Industries
· 37 students graduating from the Fd in Performance
· 10 students graduating from the Fd in Creative Music Production
This is a very exciting time and we all look forward to seeing our students receive their qualifications and awards! Watch this space for photo's from the event.
Win an iPad Mini with the Academy of Music and Sound Edinburgh!
AMS Giveaway!
Academy of Music and Sound Edinburgh have a great competition to start the year with to Win an iPad mini! All you have to do is go to the link below and fill in your details. Good luck!
Academy Of Music And Sound Swindon Results August 2015
Fantastic Results From The Academy Of Music And Sound Swindon!
Congratulations to all our 1st and 2nd year BTEC Students who have all passed their qualifications. Good luck to the second years in all that you do and welcome back to the first years who will be starting year 2 in September.
From all staff and tutors at Academy of Music & Sound, Swindon
See below the fantastic results, well done everyone!
BTEC LEVEL 3 90 Credit Diploma in Music
39 out of 42 passed = 93% success rate (11% higher than national benchmark) 3 students left before end of course and of the 39 left all 39 passed = 100%
Of which three students received the Double Award D* D* – Esme Marks, Danielle Wilkinson and Josh Wolfsohn
"Distinction* Distinction* in my first year, thankyou Ams Swindon for all your support" – Esme Marks
"Well I passed my first year of college with a double grade distinction merit. All the hard work paid off. That's not too shabby for me! Roll on next year!! Thank you Ams" – Shannon Traynor
"Very happy to say that I got the double grade Merit and Pass for my first year of college all my hard work paid off, so so happy and I can't wait for my second year of college I love Ams thank you for everything !!!" – Maddie Luckes
BTEC LEVEL 3 180 Credit Extended Diploma in Music
22 out of 22 passed = 100% success rate (18% higher than national benchmark)
Of which three students received extremely good grades: Triple Award D* D* D* Bethany Humphries, D D* D* Charlotte Iles who is joining us in October to studying for her Degree and D D* D* Abbie Sandy.
"I just want to say a huge thank you to Ams Swindon for helping me achieve D*D*D in my BTEC. This college has absolutely changed my life, and without them I wouldn't have the amazing friends and boyfriend I have today. So here's to the next three years with you guys, if you can put up with me for that long" – Charlotte Iles
Keyboards Now At Edinburgh Centre!
We are now proud to offer HNC Keyboards to our list of specialisms.
The Academy of Music and Sound in Edinburgh are specialists in Guitar, Bass, Drums, Vocals and Singer Songwriter tuition. We have been working in Edinburgh for the past 10 years delivering world class music education and training. We are now proud to add Keyboards to our list of specialisms. We are pleased to add a very limited number of places on our HNC course in Keyboards starting in August this year.
As a Keyboard player at The Academy of Music and Sound, you will receive instrument specific lessons on our Yamaha stage pianos, you will also get the opportunity to perform live regularly. In addition to work on your instrument, you will also receive instruction on Songwriting, Composition, Music Business and Professional Practice, and Music Theory.
To apply for one of these coveted spaces, you need to arrange an audition at The Academy of Music and Sound so book your slot
Glasgow Centre Prepare Applicants!
Glasgow Centre one week selection event to support and prepare applicants for interview's with employer's.
Pre-Apprenticeship/Selection Event Overview
The Academy of Music and Sound (in partnership with Fife College) have introduced a new selection process for their creative industries modern apprenticeship in music business. Anyone interested in applying for one of 58 music business apprenticeships across Glasgow and Edinburgh (starting August 2015) will be required to attend a one week selection event which has been designed to support and prepare applicants for an interview with their prospective employer.
The aim of the course is to help candidates develop their understanding of the requirements of the workplace, focusing on the challenges and requirements of working in the fast-paced music industry. In addition, participants will be given a broad overview of what it means to be an artist manager in the music industry in order to give them a taste of what is to come on the apprenticeship.
The one-week program offers applicants the opportunity to be sure that a music business apprenticeship is the right choice for them and to demonstrate their commitment, skills and motivation to their prospective employers.
Course Contents
Day 1 – Introduction to management in the UK Music Industry
Day 2 – Responsibilities of employment
Day 3 – CV's and interview techniques
Day 4 – Working in the music industry – employability training.
Day 5 – The Interview!
Those who successfully complete this short program will be awarded a SQA level 4 employability award.
All participants will be provided* with travel expenses and free lunches for the duration of the event.
*conditions/limitations apply
Glasgow Centre Apprenticeships Now!
Glasgow Centre paid apprenticeships in music business for young people aged 16-19.
The Academy of Music and Sound in partnership with Fife College are proud to announce a new programme of paid apprenticeships in music business for young people aged 16-‐19.
Interested in a career in the music industry? A fantastic opportunity for young people in the central belt of Scotland has arisen offering the opportunity to gain workplace experience with a music industry employer in addition to specialist training and support from the Academy of Music and Sound.
The music business apprenticeship offers the opportunity to earn while your learn with participants being awarded an SQA Level 6 Diploma in Music Business upon successful completion of their apprenticeship.
Apprentices will undertake 6-‐9 months of paid work experience (current min wage for apprentices is
£2.73, rising to £3.30 from October 2015) with a music industry employer in the central belt of
Scotland. Working as an artist and repertoire assistant, apprentices will gain experience in a range of music industry functions including talent scouting and artist development, marketing, sponsorship,
legal and live event promotion. Additional training will be provided by The Academy of Music and Sound in order to develop the skills, knowledge and competence required to be successful in today's music industry.
This opportunity is open to young people aged 16-‐19 who are not in work or education and who have not previously completed a level 3 modern apprenticeship. Starts are available with employers based in both Glasgow and Edinburgh – commencing 24th August 2015.
Recruitment/Selection Process
Anyone interested in applying for this opportunity will be required to attend a 5-‐day pre-‐
apprenticeship/selection event – a short intensive program designed to give interested
parties an introduction to the UK music industry, as well as the opportunity to gain an SQA employability award. On the final day of the program (delivered at AMS's Glasgow andEdinburgh
centres), all participants will be interviewed for one of the available apprenticeships commencing in August 2015.
Pre-‐Apprenticeship start dates – 13th, 20th and 27th of July. (Participants will benefit from free lunches and a travel allowance while in attendance)
See below for job description/person specification Modern Apprenticeship
– Music Business – August 2015 – Job Specification
Job Title: Artists and Repertoire Assistant (Modern Apprentice) Rate of pay: £2.73 p/h, rising to £3.30 p/h as of October 1st
• Research and recruit new musical talent for the Scottish Music scene (via demo submissions, web research and attending live events)
• Artist development activities to include planning and booking recording sessions, developing and agreeing on repertoire.
• Organizing live events/showcases and touring to support and increase artist
• Networking on behalf of artists to secure commercial opportunities in the live, recorded and publishing sectors of the industry.
• Working with artists to develop their creative branding in terms of design, biographies, logos, web
• Planning and executing social media marketing strategy.
• Fundraising activities in support of label artists e.g. Developing and executing kick-starter and pledge music campaigns.
• Administrative duties in support of the above.
Candidate specification:
• A keen interest in commercial music of all genres (essential)
• Good written and oral communication skills (essential)
• A working knowledge of MS office packages e.g. word, excel, powerpoint (essential)
• Highly motivated with a desire to seek out new underground talent (essential)
• Able to work autonomously and also as part of a team (essential)
• Knowledge of the music scene in your area and more widely throughout Scotland (desirable)
• Some relevant music industry
experience e.g. live events promotion recording, performance (desirable)
• Experience of planning and executing complex projects (desirable)
Recruitment/Selection process:
• Interested parties are invited to submit a CV and a short covering letter indicating why they are interested in the position and any relevant experience.
• All applicants will be expected to attend a (mandatory) selection program during
which they will
receive training in employability and management in the UK music industry.
• Applications should be submitted to firstname.lastname@example.com
(0141 221 4458) or email@example.com (0131 656 0600)
• Assessment courses will take place w/c 13th, 20th and 27th of July 2015.


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The Pod Works3
32/34Henry Street, Liverpool, L1 5BS
Price FromView Rooms
- Very Good
- 137 guest reviews
"It's a good hotel for a good stay in a nice city. Surprising Liverpool...."
"Small room but as a Base for the city, it's fine. 2 mins walk from Liverpool One. Ideal for single traveller..."
"For a quick turnaround in Liverpool, this could not be beat!! Central/ clean/ cheap - ideal!!..."
"The Pod Works is a great place to stay,it is near the centre of the city, the rooms are great the Staff are very friendly and it also beats..."
"Great little hotel, very clean, helpful and friendly staff, perfect location!! Would definately stay here again :)..."
About the hotel
A new concept in accommodation comes to Liverpool ! There's a Pod for every person, and an endless range of possibilities. The Podworks Hotel offer hip, convenient and personalized accommodations for the stylish and spend thrifty traveller. The Hotel is located in the heart of Liverpool and Liverpool is the number one choice for visitors on a budget.
Each Pod is individually climate controlled and equipped with efficient, stylish furniture that's designed to maximize your comfort and your living space. And you don't skimp on style. Or pay grand hotel prices. The Pod works Hotel is where you sleep, in a city that doesn't. It's dead central. Because anywhere else would be just. . . . dead. That means that you can check into your room, congratulate yourself on choosing a central hotel with uber-modern interior design, then go and check out the city. So what do you need for an great Stay? The essential comforts. Crisp bed linen. An en suite bathroom. Stylish design. Plus the city on your doorstep; so you can work or play as late as you like - then simply saunter back to the Pod worksHotel, drop into the Pod Cafe for a refresher, and then off to your Pod bed If you love cities, you'll really love the Pod works Hotel. Adjustable climate control A/C High-quality wood and leather fittings Full-size double bed with deluxe mattress All rooms have a 32" smart tv screen with multi-channel entertainment. Complimentary WiFi access throughout the hotel Tea and coffee making facilities 9 square metres of luxury proving that good things really do come in a small packages. Never fear! We also have hairdryers and other essentials. so everything is here, it's just not cluttering up your Pod. Enjoy !
Read MoreLess
Room Availability
Showing Wednesday 14 October 2015 to Thursday 15 October 2015Change Search
Facilities Show/hide
- Main
- Hotel Non-Smoking Throughout , Disabled Facilities
- In room facilities
- Air conditioning in rooms , Tea/Coffee making facilities in each room , Hairdryer in each room
- Hotel services
- 24 Hour Reception , 24 Hour Room Service , Limited room service for hot food , Concierge
- Business
- Wi-Fi Available , In-room Broadband , Wi-Fi Available In Public Areas , Wi-Fi Available In Rooms
- In room entertainment
- TV , Satellite TV , [Channels] News , [Channels] Sky Sports , [Channels] Movies (Pay Per View)
- Other
- Lift to all floors , Public Air Conditioning
- Parking
- Car Parking Available Offsite
- Accessibility
- Disabled Access Public Areas , Disabled Access Bedrooms , Disabled toilets on ground floor , Wheelchair Access , Wheelchair Access To Reception , Wheelchair Access To Restaurant , Wheelchair Access To Bar , Wheelchair Access To Disabled Car Parking Spaces
- Dining
- Lounge Menu , Bar , Breakfast to go
Useful Info Show/hide
- From 16:00 hours
- Until 11:00 hours
- The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are not allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
84% would recommend it to a friend
Customer service
Food quality
Room quality
Pretty hotel for short breaks
It's a good hotel for a good stay in a nice city.
Surprising Liverpool.
Read More Less
Adequate for quick overnight stay
Room is ideal for a night out in the city.
I attended a launch night and even though I live in Liverpool wanted to just have a sleep before I went home to a mad house full of kids. The room needs a good clean. The leather around the bed was terrible and could have been cleaned properly. I had room 201 and early in the morning could here loads of running water, could have been pipes in the wall. Also that room is right next to the main hall door. Top tip, don't stay in 201. Outside the building are huge rubbish bins, not the best feature for a hotel, especially when they are overloaded with rubbish
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Photoshop & Maxon Cinema 4D tutorial: Learn the best ways to create 3D type
Christopher Vinca explains how to produce realistic-looking 3D letters with accurate lighting and textures
Christopher Vinca explains how to produce realistic-looking 3D letters with accurate lighting and textures
Give your images a boost with James White's slick pop style
Discover how the artist composited this stunning artwork for the cover of the Pendulum's Number 1 album, Immersion.
Dive down the rabbit hole to create Alice in Wonderland poster art.
Learn how to edit a photo using Photoshop CC's new Camera Shake Reduction and Smart Sharpen features and the Camera Raw filter.
How to make a group shot subtly more dynamic by applying some of Photoshop's adjustment layers and blending modes.
Discover how the accomplished use of shadows and textures can give depth to your work.
How to create a psychedelic artwork using a mix of adjustment layers, effects and vector elements.
Discover subtle ways of making your photography even more beautiful using Photoshop CC's new filters.
Produce colourful, rounded graphics with Photoshop CC.
Eric Kim walks us through the different techniques he used to produce this black-and-white manga-style illustration
Ustwo's chief pixel-perfectionist reveals the best way to design phone and tablet
By applying patterns and textures to a retro-styled illustration, you can add extra depth to your work
Nicolas Monin-Baroille explains the different Photoshop and Illustrator techniques he used to create this abstract artwork
Lizzie Mary Cullen looks at how colour can make an image pop
Learn how how to create a stylish 3D typographic illustration using only Illustrator and Photoshop.
How to create a striking monochrome landscape from a series of photos using techniques Stephen Chan developed for an illustrator for Esquire.
Adi Gilbert explains how hand-drawn art can be enhanced by digital techniques to produce beautifully-crafted illustrations
Usings Photoshop and Illustrator, it's possible to create a fantasy scene using brushes and blur effects to their fullest.
Thomas Burden adds texture to lifeless renders of 3D elements


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Harrys Hotel Bar & Bistro2
Harrys Hotel, Bar and Bistro, Aberystwyth, SY23 2NF
Price FromView Rooms
- Very Good
- 55 guest reviews
"Spent a Saturday night at Harry's we were taking our son to university. Excellent staff vey friendly and helpful. Rooms clean and tidy...."
"Convenient and central location.Very pleasant and helpful staff. Limited car parking spaces at the rear of hotel...."
"Great room, excellent location, friendly helpful staff. Good food and service in restaurant...."
"Why don't more hotels do this? The room was actually very quiet considering the hotel is in the town centre. Another big plus was breakfast..."
"This hotel has lots of character very welcoming with helpfull and friendly staff. Would recommend..."
About the hotel
Harrys Hotel was newly renovated in 2008, making all rooms en-suite. Harrys has a range of rooms from singles to deluxe rooms, which will suit all types of travellers. The staff and management in Harrys look to achieve a friendly, relaxed and warm environment that will bring customers back again.
A residence with a sense, of elegances and warmth. Harrys is conveniently located in the heart of Aberystwyth. It is located near the waterfront, train station and shopping centre; Harrys is an ideal choice for any visit, with friends or family. Room Facilities * Wake-up calls (on request) * Ironing Fax facilities (on request) * Free view LCD T. V * Tea and Coffee facilities * WIFI (Password for the WIFI can be obtained from the bar and reception)
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Room Availability
Showing Saturday 10 October 2015 to Sunday 11 October 2015Change Search
Facilities Show/hide
- Main
- Hotel Non-Smoking Throughout
- Parking
- Car parking available onsite , Car Parking Available Offsite
- Business
- Wi-Fi Available , Wi-Fi Available In Public Areas , Wi-Fi Available In Rooms , Private dining services
- Dining
- Restaurant , Lounge Menu , Bar , Breakfast to go
- In room entertainment
- TV , Satellite TV , [Channels] News
- In room facilities
- Tea/Coffee making facilities in each room , Hairdryer in each room
- Hotel services
- Wake Up Call Available
Can't find the facilities you're looking for?
- Call us on 0333 300 1007 and we'll help find the perfect hotel for you
- Call
Useful Info Show/hide
- From 00:00 hours
- Until 11:00 hours
- The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are not allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
91% would recommend it to a friend
Customer service
Food quality
Room quality
On reception at check in, no information supplied.
Dirty, old fashioned room. No colld water in the bathroom in the evening so unable to flush the loo, although this was Ok by the morning. More suited to party people / stag do's.
Read More Less
Great staff
Spent a Saturday night at Harry's we were taking our son to university.
Excellent staff vey friendly and helpful. Rooms clean and tidy.
Read More Less


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Traffic 2011; 12: 89–101
© 2010 John Wiley & Sons A/S
In vivo Imaging of Retrogradely Transported Synaptic
Vesicle Proteins in Caenorhabditis elegans Neurons
Kausalya Murthy†, Jaffar M. Bhat†and Sandhya
P. Koushika∗
Neurobiology, NCBS-TIFR, Bellary Road, Bangalore
560065, India
*Corresponding author: Sandhya P. Koushika,
†These authors contributed equally to this work.
Axonal transport is an essential process that carries
cargoes in the anterograde direction to the synapse and
in the retrograde direction back to the cell body. We have
developed a novel invivo method toexclusively mark and
dynamically track retrogradely moving compartments
carrying specific endogenous synaptic vesicle proteins
in the Caenorhabditis elegans model. Our method is
based on the uptake of a fluorescently labeled anti-green
fluorescent protein (GFP) antibody delivered in an animal
expressing the synaptic vesicle protein synaptobrevin-
1::GFP in neurons. We show that this method largely
labels retrogradely moving compartments. Very little
labeling is observed upon blocking vesicle exocytosis
or if the synapse is physically separated from the cell
body. The extent of labeling is also dependent on
the dyenin–dynactin complex. These data support the
interpretation that the labeling of synaptobrevin-1::GFP
largely occurs after vesicle fusion and the major labeling
likely takes place at the synapse. Further, we observe
that the retrograde compartment carrying synaptobrevin
contains synaptotagmin but lacks the endosomal marker
RAB-5. This labeling method is very general and can
be readily adapted to any transmembrane protein on
synaptic vesicles with a GFP tag inside the vesicle and
can also be extended to other model systems.
Key words: antibody, dyenin–dynactin mutants, ret-
rograde axonal transport, synaptic vesicle proteins,
Received 3 March 2010, revised and accepted for
publication 1 October 2010, uncorrected manuscript
published online 4 October 2010, published online 29
October 2010
Retrograde transport is the process in which cargo is
transported back to the cell body from the synapse.
The major retrograde motor in axons is thought of
as the dynein–dynactin complex (1). The importance
of retrogradetransportisshownbyneuronalandneurolog-
ical phenotypes observed in animals that have mutations
in the dynein–dynactin complex components (2). Retro-
grade transport plays very important roles in modification
such as amyotrophic laterla scleosis (ALS) (3).
Several cargoes are transported retrogradely, e.g. mito-
chondria, synaptic vesicle proteins, neurotrophin recep-
tors, viruses and exogenously applied toxins such as
tetanus toxins (4–8). As most cargoes exhibit saltatory
bidirectional movements and dynamic imaging of trans-
port is usually feasible only in the shorter time scale
of minutes, it is not always easy to determine which
endogenously expressed proteins are retrogradely trans-
ported from the synapse to the cell body. For example,
a few synaptic vesicle proteins have been inferred to be
retrogradely transported by their observed mislocalization
in mutants of the retrograde motor dynein (e.g. the trans-
membrane proteins synaptobrevin and synaptotagmin in
Caenorhabditis elegans) or by their distal accumulation in
a nerve crush assay (e.g. synapsin, synaptotagmin, RAB-3
in vertebrates) (9–11). An in vivo method to specifically
tag retrograde cargo will offer a direct means to study
mechanisms of retrograde transport, to separate retro-
gradely moving cargo pools from anterogradely moving
pools and to study processes that depend on retrograde
transport such as axonal injury signaling (12).
Methods that specifically assay retrogradely transported
compartments use exogenously applied probes such as
radiolabeled nerve growth factor (NGF) (13), fragments
of tetanus toxin tagged with fluorophore (14), ligands
to activate Trk receptors (15) or viruses (7,8). However,
these methods have mostly been used in cell culture.
Moreover, they do not provide simple means to
specifically label a given protein to allow dynamic tracking
in vivo. Currently,the most widely used trackingmethod is
totagtheproteinofinterestwith greenfluorescentprotein
(GFP). However, using this technique alone it is difficult to
systematically and exclusively follow events that begin at
and offer an attractive means to label the desired protein
and thus the compartments in which it travels. Antibody-
based labeling techniques have been tried to study
retrograde transport (16,17), but many of these attempts
predated the development of canonical protein tags such
as hemagglutinin (HA) or GFP. Specific antibodies against
a non-fluorescent tag have been used recently for static
tracking, while studying receptor recycling at postsynaptic
sites in cell culture (18,19). But no general methods have
been developed to dynamically track retrograde transport
of any desired protein in vivo.
We have developed a tool to exclusively visualize the ret-
rograde transport of GFP-tagged synaptic vesicle proteins
in neurons in vivo. Our approach is based on inject-
ing Alexa Fluor®594-conjugated immunoglobulin G (IgG)
anti-GFP antibodies into transgenic C. elegans lines that
stably express GFP tagged to the synaptic vesicle protein
Page 2
Murthy et al.
Figure 1: Antibody against GFP specifically labels synaptobrevin::GFP in neurons. A) Schematic of the retrograde labeling assay.
Neurons expressing SNB-1::GFP (green dotted line) on vesicles with GFP tag within the vesicle, when exocytosed, is exposed to
extracellular environment. The exposed SNB-1::GFP stably binds to injected Alexa Fluor 594 GFP antibody; the bound antibody is
endocytosed resulting in retrograde labeling in the same neuron (red dotted line). B) Schematic of jsIs37 animals showing the pattern
of expression of SNB-1::GFP in anterior and posterior neurons (ALM and PLM). ALM neurons make synapses in the nerve ring (arrow)
and PLM makes synapses in the ventral cord (arrow). An arrow points to the 'synaptic branch' from the main PLM neuronal process
that enters the ventral cord to form synapses. C) Retrograde labeling of neurons 1 h after antibody injection in jsIs1 animals expressing
SNB-1::GFP in all neurons and in the PLM neurons of jsIs37 that express SNB-1::GFP (in green, top panel), SNB-1::GFP-Ab (in red, middle
panel) and merge (in lower panel). White box points to a neuronal region near the cell body where SNB-1::GFP-Ab signal is quantified in
subsequent figures. D) Immunostaining of anti-GFP antibody that has undergone endocytosis in zdIs5 (left) that expresses soluble GFP
in touch receptor neuronal processes and motor neuron synapses of oxIs103 (right) that expresses UNC-46::GFP (a transmembrane
presynaptic vesicle protein) in GABA neurons stained for GFP and SNB-1::GFP in mechanoreceptor neurons (jsIs37). E) Representative
images of jsIs821 and zdIs5 worms expressing GFP::RAB-3 and soluble GFP but do not show any signal in red channel. F) Coelomocyte
labeling 1 h after Ab injection as a control for working antibody.
Arrowhead points to neuronal process. In all images, scale bar is 10 μm except in the oxIs103 panel (D), scale bar is 5 μm.
points to non-specific autofluorescence from the pseudocoelom.
synaptobrevin-1 (SNB-1) in neurons (20). The injected
anti-GFP antibody binds specifically to SNB-1::GFP that
exposes GFP to the extracellular milieu upon vesicle exo-
cytosis (Figure 1A). The SNB-1::GFP-Ab is subsequently
endocytosed within a vesicle. The brightness and stability
of the fluorescent antibody facilitateslong-term imaging of
retrograde transport of specific transmembrane proteins.
Our technique gives a powerful in vivo labeling tool that
can be used to visualize and track GFP-tagged SNB-1, the
transmembrane synaptic vesicle protein UNC-46 or simi-
larlytagged transmembraneproteins thathave been endo-
cytosed from the plasma membrane, likely at the synapse.
The only condition necessary to exploit this approach is
that the GFP domain of the tagged protein must be inside
the vesicle so that the GFP domain is exposed to the
extracellular space after the vesicle undergoes exocyto-
sis (Figure 1A). Furthermore, this method can be used
to characterize the retrogradely moving compartment,
as we show that the retrograde compartment carrying
Traffic 2011; 12: 89–101
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Specific Labeling of Retrogradely Transported Proteins
SNB-1 also contains SNT-1 but not RAB-5. Potentially, this
general technique can also be used in other transparent
or translucent model organisms.
Results and Discussion
A fluorescently marked antibody against GFP
specifically labels synaptic vesicle proteins in vivo
One-day adult C. elegans worms of the jsIs1 transgenic
strain that stably express SNB-1::GFP pan-neurally (20)
were injected in the pseudocoelom with a 1:10 dilution
of Alexa Fluor 594 IgG antibody against GFP (Ab). This
transgenic strain rescues a null allele of snb-1 and is
localized and trafficked like the endogenous protein (20).
After an incubation period of 1 h post-injection at 22◦C,
not only could we visualize the vesicles marked with
SNB-1::GFP in the green channel as expected, but also
SNB-1::GFP marked with Alexa Fluor 594 anti-GFP IgG
antibody (referred to henceforth as SNB-1::GFP-Ab) in
the red channel (Figure 1C, left). SNB-1::GFP-Ab could be
detected only in regions of the neuron that show the pres-
ence of SNB-1::GFP. This included synapse-rich regions of
the ventral cord, dorsal cord, nerve ring and neuronal pro-
cesses.No detectablesignalwasobservedinthedendritic
processes in the head region (data not shown). Simi-
larly, jsIs37 worms that stably express SNB-1::GFP only
in six mechanoreceptor or touch receptor neurons (20)
(Figure 1C, right; Figure S1D), when injected with Ab
and incubated for 1 h, showed varying intensities of
SNB-1::GFP-Ab exclusively in these neurons. The inten-
sity of labeling varied from low to high with most animals
showing labeling between medium and high and fewer
animals showing low labeling and the intensity of labeling
changed over time (Figure S1B). As described earlier (21),
the scavengercellcoelomocytes were also labeled in each
experiment and their labeling remained nearly invariant
over time (Figures 1F and S1A). This labeling was used
as an indication of whether the assay worked, i.e. we
found that if coelomocytes were not labeled, no signal
was observed in neurons either and the animals and the
Ab dilution were discarded.
To rule out non-specific binding followed by endocytosis
of Alexa 594 IgG Ab, two control experiments were per-
formed. We injected and imaged jsIs821 (22) transgenic
worms (n = 9), which express the peripheral membrane
protein GFP::RAB-3 on the surface of the synaptic vesi-
cle (23). Upon synaptic vesicle exocytosis, the GFP on
RAB-3 remains intracellular and will not be exposed to
the anti-GFP Ab in the extracellular space. Hence after
injection of the Ab, as expected, GFP::RAB-3 could be
visualized in the touch receptor neurons in the green
channel but no corresponding signal could be visualized in
the Cy3 channel (red), showing that the Ab binds specif-
ically only to the GFP that is exposed to the extracellular
space by exocytosis (Figures 1E and S1B). Similar results
were seen in injected zdIs5 worms (n = 10) that express
soluble GFP intracellularly in the mechanoreceptor neuron
(Figures 1E and S1B) (24). In both these strains, coelo-
mocytes showed significant labeling (Figure 1F). Further,
the number of coelomocytes labeled increased with
time unlike in SNB-1::GFP animals injected with the
labeled antibody (Figure S1A). This is consistent with
more available Ab for coelomocyte uptake in soluble
GFP and GFP::RAB-3-expressing strains compared with
SNB-1::GFP-expressingstrains.In SNB-1::GFP-expressing
strains coelomocyte labeling stays constant, probably
because touch receptor neurons compete with the scav-
enger cells for uptake.
Detection of SNB-1::GFP-Ab but not GFP::RAB-3 nor solu-
ble GFP suggests that the GFP attached to SNB-1 is likely
to be exposed to the extracellular surface, where it is
recognized by the Ab. This labeling could occur at synap-
tic regions as SNB-1::GFP is exposed to the extracellular
milieu upon synaptic vesicle fusion. The labeling all along
the neuron and the cell body could be a consequence of
retrograde axonal transport.
We used our images to estimate how many SNB-1::GFP
punctae also contain SNB-1::GFP-Ab and observed that
more than 90% of the large green SNB-1::GFP vesicles
were also labeled with SNB-1::GFP-Ab (150/158, n = 9
worms) (Figure S1D). These data suggest thatmany of the
bright SNB-1::GFP vesicles may be in retrogradely moving
compartments, while anterogradely moving SNB-1::GFP
may be in smaller compartments and thus more difficult to
clearly detect as distinct bright punctae. Consistent with
this, we see significant 'diffuse' SNB-1::GFP signal in the
neuronal processes between the bright punctae, which
contain both SNB-1::GFP and SNB-1::GFP-Ab (Figure 1D,
Figure 3A?, data not shown).
To testifthis methodcould beused on othersynapticvesi-
cle proteins tagged with GFP on their lumenal domain, we
injected an anti-GFP Ab in the UNC-46::GFP-expressing
strain, oxIs103 (25). UNC-46 encodes a transmembrane
protein present on synaptic vesicles and is required to traf-
fic the vesicular γ-Aminobutyric acid (GABA) transporter to
synaptic vesicles (25). We injected an anti-GFP Ab uncon-
jugated to fluorophore, allowed time for endocytosis, fixed
and stained with a secondary Ab (refer to Materials and
Methods). We see specific labeling of a UNC-46::GFP-
carrying compartment in motor neurons after allowing for
anti-GFP Ab endocytosis even for 10–15 min. At this time-
point, UNC-46::GFP-Ab is present at synapses (Figure 1D)
and a small amount of this signal is also visible in the neu-
ronal process near the cell body and in the cell body, sug-
gesting that the UNC-46::GFP-Ab compartment may also
be retrogradely transported. Identical data were obtained
when living oxIs103 animals were visualized after being
injected with Alexa 594-conjugated anti-GFP antibodies
(Figure S1D). The fluorophore-unconjugated anti-GFP Ab
likewise specifically labels SNB-1::GFP in touch receptor
neurons (Figure 1D). This labeling looked nearly identical
to animals injected with Alexa 594-conjugated anti-GFP
Ab and visualized in living animals (Figure 1C,D). Further,
Traffic 2011; 12: 89–101
Page 4
Murthy et al.
worms that express soluble GFP in neurons do not show
any endocytosed anti-GFP Ab signal while still showing
soluble GFP signal, which is not abolished by the fixation
procedures (Figure 1D).
Taken together, we have developed a method to label
specific lumenally tagged synaptic vesicle proteins in vivo.
The labeling depends on the exposure of the GFP tag to
the extracellular milieu allowing the antibody access to the
proteins as they cycle through the plasma membrane.
Retrograde labeling kinetics in mechanoreceptor
If the labeling of SNB-1::GFP takes place predominantly
at synaptic regions, one would expect it to label synaptic
regions more quickly, followed by an increase in other
parts of the neuronal process if the labeled SNB-1::GFP
undergoes retrograde transport. To determine the labeling
kinetics, we quantitated the labeling intensity of SNB-
1::GFP-Ab in the anterior lateral microtubule cells (ALM)
and posterior lateral microtubule cells (PLM) (Figure 1B) in
different regions of these neurons and at different time-
points. Each posterior mechanoreceptor neuron (PLM)
gives out a single synaptic branch (Figure 1B), which ends
in approximately 11 en passant synapses closely clustered
in about an 8–15-μm region in the ventral cord (20,26)
(Figure 2C). Similarly, the anterior cell makes several
synapses restricted to a small region in the nerve ring. The
close spacing of the synapses below the optical resolution
of a light microscope precludes our ability to track
movement of labeled vesicles between synapses, unlike
such observations made by Darcy et al. (27) in cultured
vertebrate neurons. The regions quantitated in the
synaptic branch (Figure 2, box) and the neuronal process
near the cell body are both spatially several millimeters
away from the synaptic clusters. Thus, the labeling
quantitated along the neuronal process is likely to arise
only from retrograde transport of labeled compartments.
To make appropriate quantitative comparisons, all data
were normalized to the synaptic signal observed at the
15-min time-point with SNB-1::GFP. We collected images
of SNB-1::GFP and SNB-1::GFP-Ab at 15 min, 30 min,
45 min, 1 h, 3 h, 6 h, 9 h and 12 h post-injection. Some
representative images of the PLM neuron at the neuronal
process near the cell body (indicated in figures and graphs
as cell body), at the mechanoreceptor neuron branch and
at the synaptic region are shown in Figure 2A–C, respec-
tively. Imaging ALM neuron synapses proved challenging
because the synapses are distributed over different opti-
cal planes unlike in the PLM neurons. Further, the branch
geometry is not easily visualized and there is very high
autofluorescence in the region near the ALM cell body
as it is in the middle of the animal. Region-specific quan-
tification of the data in PLM neurons (n = 8–12 worms)
reveals that both at the synapse and in the neuronal pro-
cess near the cell body, the intensity initially increases
and then decreases with time. But the rise near the cell
body is slower and to a lower peak level compared to the
rise at the synapse. The subsequent decrease also occurs
later near the cell body than at the synapse (Figure 2D).
The decrease in labeling at synaptic regions in both ALM
and PLM neurons at later time-points could arise because
of decreased uptake (endocytosis) of the antibody along
synapse. After 9–12 h almost no SNB-1::GFP-Ab signal is
observed in both ALM and PLM neurons.
Taken together, injecting a fluorophore-tagged anti-GFP
antibody into the pseudocoelom specifically labels SNB-1::
GFP. Further, the labeling kinetics support the hypothe-
sis that this Ab is labeling vesicles at synapses and that
at least a portion of them may contribute to the slower
body. However, we cannot exclude that labeling occurs
directly in the cell body as has been reported for trafficking
of synaptobrevin in cell culture (28). Nor can we assess
with this method how much of the signal arises from
the known plasma membrane pools of SNB-1 that escape
endocytosis (29). However, our approach still provides a
useful tagging method and the experiments in the ensuing
sections will support the validity of our method to study
retrograde transport of SNB-1.
Time-lapse imaging of movement of SNB-1::GFP-Ab
in neurons
We hypothesized from the observed patterns in the sig-
nal of SNB-1::GFP-Ab that majority of the labeling of
SNB-1::GFP was likely occurring at synapses and specif-
ically it is SNB-1::GFP-carrying retrograde compartments
that are labeled in the touch receptor neurons. We tested
this by time-lapse imaging of jsIs37 strains that were
injected with the Ab at the 1 h post-injection time-point.
Regions of the ALM neuron proximal to the cell body were
imaged. Not only could we track many retrograde events
along with very few anterograde events, imaging could be
performed for approximately a minute without significant
photobleaching (Movie S1, cell body on the right). This
allowed us to quantitatively analyze the transport proper-
ties of carriers with SNB-1::GFP-Ab, such as velocity and
flux, and compare them with the transport properties of
SNB-1::GFP carriers (Figure 2E,F). We found that more
than 95% of the SNB-1::GFP-Ab particles move in the ret-
rograde direction, while only 35–45% of the SNB-1::GFP
particles move in the retrograde direction. We also find
that the velocity of retrogradely moving SNB-1::GFP-Ab
is very similar to retrogradely moving SNB-1::GFP
(Figure 2F). Further, we estimate that only about 20–30%
of the retrogradely moving SNB-1::GFP are labeled with
SNB-1::GFP-Ab. This may arise from inefficient labeling
of retrograde compartments after endocytosis, but could
also arise from anterogradely moving SNB-1::GFP show-
ing reversalstomoveretrogradelyinthe neuronalprocess.
It is also possible that retrogradely moving cargoes move
infrequently with long pauses, thus at any given imag-
ing time most SNB-1::GFP-Ab are stationary (Figure 2E,
arrow). Consistent with this possibility, we observe a large
number of stationary collections of SNB-1::GFP-Ab in the
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Specific Labeling of Retrogradely Transported Proteins
Figure 2: Labeling kinetics and dynamic imaging of SNB-1::GFP-Ab in touch receptor neurons. Images of retrograde labeling
in different regions: (A) neuronal process near the cell body, (B) neuronal process near the branch and (C) synaptic regions of PLM
neurons in jsIs37 that express SNB-1::GFP (top panel) with SNB-1::GFP-Ab (lower panel). Boxed region of the branch was quantified
in each image (B; SNB-1::GFP-Ab panel). D) Quantitative representation of SNB-1::GFP-Ab labeling in different regions of the PLM and
ALM neurons normalized to synaptic SNB-1::GFP signal plotted as a semilog plot, where incubation = hours after anti-GFP injection
represented on the x-axis as log of time to the base 2. Data are represented as mean ± SEM, n = 8–12. E and F) Dynamic imaging
of SNB-1::GFP-Ab and SNB-1::GFP. E) Kymographs showing displacement (x-axis) of SNB-1::GFP (n = 15) and SNB-1::GFP-Ab (n = 6)
vesicles over time (y-axis) of the same neuron, acquired by live imaging in green and red channels of Ab-injected jsIs37 neurons. White
arrowhead points to a SNB-1::GFP-Ab particle that may be switching direction of movement from anterograde to retrograde (reversal).
Arrow points to stationary SNB-1::GFP-Ab particle (F). Average velocity and flux of SNB-1::GFP and SNB-1::GFP-Ab calculated from
kymographs generated from time-lapse movies.
points to non-specific autofluorescence from the pseudocoelom and arrowhead
points to the neuronal process in A and B. Box in B points to region of the synaptic branch quantified in Figures 2, 3 and 5. Data are
represented as mean ± SEM. Scale bar = 10 μm.
Traffic 2011; 12: 89–101


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text: Home > Medical > Stroke > News Updated 05 April 2013 Stroke survivors consider suicide About one in 12 stroke survivors in the United States thinks about suicide or wishes that they were dead, a new study indicates. 0 About one in 12 stroke survivors in the United States thinks about suicide or wishes that they were dead, a new study indicates. The findings suggest that it might be a good idea to regularly screen stroke survivors for depression and suicidal thoughts, the researchers said. The investigators analysed data from the 2005 to 2010 US National Health and Nutrition Examination Surveys and found that nearly 8% of stroke survivors reported suicidal thoughts, compared with about 6% of heart attack survivors, 5% of diabetes patients and 4% of cancer patients. The proportion of stroke survivors who thought about suicide was surprising, compared to patients with other health issues, noted study lead author Dr Amytis Towfighi, an assistant professor of clinical neurology at the University of Southern California in Los Angeles and chair of neurology at the Rancho Los Amigos National Rehabilitation Center. Regular screening warranted Stroke survivors who had more severe depression, were younger, had higher body mass index (a measurement of body fat), had less education, and were poorer, single or women were more likely to have suicidal thoughts, according to the study presented Thursday at the American Stroke Association annual meeting, in Honolulu. 17% of the people who'd had a stroke also had depression, which is the most common mental health complication in stroke survivors, the study authors noted. "Given the high prevalence of suicidal thoughts among stroke survivors, perhaps regular screening for suicidal ideation, in addition to depression, is warranted," Towfighi said in an American Heart Association news release. Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal. There are about 7 million adult stroke survivors in the United States, according to the American Stroke Association. (HealthDay News, February 2013) Read More: Depressed stroke survivors face triple death risk From our sponsor Find MyStroke on Facebook Know the facts about stroke Read Health24's Comments Policy Comment on this story 0 comments Comments have been closed for this article. Logout Comment 0 characters remaining Share on Facebook Loading comments... Ask the Expert Stroke Expert Dr Naeem Brey completed his MBChB (Bachelor of Medicine and Surgery) degree in 2003 at the University of Cape Town. In 2010 he started he started specialising in Neurology at Tygerberg Hospital and graduated with his specialist exam in FCNeurol (Fellowship of the College of Neurology) in May 2013. He has a particular interest in stroke as well autoimmune and demyelinating neurological illnesses. Read more about Dr Naeem Brey Ask a question Questions posted to Stroke Expert questions answered by the expert Q: heart operation and bioplus posted on 05-10-2015 Q: Mother struggles to sleep after stroke posted on 04-10-2015 Q: Rehabilitation program to help speed up the recovery of stroke pts? posted on 26-09-2015 Q: Stroke symptoms? posted on 05-09-2015 Q: Tingling in my right hand, tongue and face paired with headache? posted on 14-08-2015 Q: ICA Aneyurism posted on 11-08-2015 Q: Can an operation cause a TIA? posted on 24-03-2015 Q: stroke posted on 02-03-2015 Q: suffer from heart problems posted on 19-02-2015 Q: Do I need to change my eating habits, am I at risk to get a stroke? posted on 17-02-2015 Q: Suffered a stroke recently, heart rythm out. Is Nuzak safe to use posted on 23-01-2015 load more × Still have a question? Get free advice from our panel of experts Your question More detail Your name (optional) The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content. I agree * You must accept our condition To prevent spam please solve this simple math problem: Forum Rules


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Niko Porikos grew up in an NTDP billet home. Cool story.
The Chaos Team: Examining Tennessee's Losses
Both of these teams swept Tennessee. One is good. One is not.
Tennessee is such a strange team—capable of beating Virginia by 35 or getting swept by Texas A&M—that a look at a game or two of film seemed like a potentially huge waste of time. Instead, I went through the box scores and available highlights of each of the Volunteers's 12 losses in an effort to find some common threads. Without further ado, here's the breakdown of each game, with a Michigan-centric overview at the end of the post.
All rankings reflect the current KenPom standings, which have Tennessee at #6.
#59 XAVIER 67, TENNESSEE 63 (Nov. 12, Away)
Key Tennessee stats: 16/38 2-pt, 8/19 3-pt, 7/19 FT, 35% OR, 17% TO
Key Xavier stats: 24/46 2-pt, 2/8 3-pt, 13/24 FT, 41% OR, 25% TO
Breakdown: Xavier led wire-to-wire in Tennessee's season opener despite missing two starters. They were helped by terrible shooting inside the arc by the Vols, as well as significant foul trouble for Tennessee's two bigs—Jarnell Stokes fouled out in 20 minutes and Jeronne Maymon had four fouls in 27. Xavier exploited this by generating a ton of shots inside the arc and rebounding far better than Tennessee's opponents normally do. The Volunteer bench, meanwhile, scored just six points in 57 minutes of playing time. Score one for "get the bigs in foul trouble" as a huge key to beating UT.
#96 UTEP 78, TENNESSEE 70 (Nov. 28, Neutral Site)
Key Tennessee stats: 19/42 2-pt, 3/21 3-pt, 23/39 FT, 54% OR, 21% TO
Key UTEP stats: 26/40 2-pt, 3/10 3-pt, 17/26 FT, 23% OR, 19% TO
Breakdown: Once again, shooting struggles got Tennessee into an early hole. Once again, foul trouble didn't help, as Maymon fouled out of this one in 22 minutes — he'd been bad anyway, going 1/6 from the field. I don't know if there's much to analyze from this, especially from Michigan's perspective. The Vols shot poorly enough that rebounding over half their misses didn't help much, and UTEP is one of the tallest teams in the country—they played five players standing at least 6'8" for 10+ minutes in this game.
[Hit THE JUMP for ten more losses and my takeaways from a Michigan perspective.]
This Week's Obsession: Calculating a Factor of B
Hey, look, a recruit. Now that the drought...
So the Spring Game is in a week. What should we be looking...
You have heard tell of the Beilein Factor, a bracket variable mathematically expressed as "" that allegedly extends the tourney life of Beilein-coached teams. Do you believe in ? What causes ? Is it more dangerous to meet a -factor team where 's time to prepare for you > 5 days, or is the converse true, wherein <2 days to prepare for = greater chance of tournament death?
Brian: We are dealing with small sample sizes here, but since it's all we have to go on... yeah, there does seem to be something about meeting John Beilein in the tournament that makes things go poorly for their opponents.
|Theory: If you'd never seen the 1-3-1 and were expecting to play the Mountaineers' 1st round opponent, it can be tough to crack it in 2 days of practice. [Courtesy WVU Sports Communications]
Before his Michigan days, you could chalk that up to the weirdness of coming up against the 1-3-1 zone. The easy theory was that conference opponents had a grasp on how to attack it and few others did. Ditto getting Pittsnogled. While it's more common these days, a decade ago the specter of a 6'11" guy raining on you was enough to create a verb.
These days Beilein runs man to man and Dirk Nowitski exists, so big guys who can shoot are just uncommon, not insane. I mean, MSU--the platonic opposite of Beilein basketball--has two bigs who shoot threes. And yet, Beilein has taken Michigan to the tourney five times, solidly exceeding expectations three of those times with one first-round upset and the fifth still pending.
The reasons are a bit more obscure these days, other than the usual "John Beilein is a genius seriously" tag. The general difficulty of getting everything covered in Beilein's offense of cuts and reads and options is a large part of it, of course. The other part is player development. Michigan guys get a lot better, and while the leaps are most notable between seasons that unusual rate of improvement is happening throughout the year. Michigan teaches constantly, and by the end of the year they're incrementally better than the teams they played early in the season are.
That's my best guess, anyway.
[Jump for more guesses]
Exit Alex Guptill
Aaand Alex Guptill took about 30 seconds to follow Phil Di Giuseppe out the door:
Another #Wolverine signed, Alex Guptill with @DallasStars - remember watching him shine with the Brampton Capitals. #OJHL #DallasStars
— Mark Edwards (@MarkEdwardsHP) March 26, 2014
Guptill was the bar-none most frustrating player I can remember in 15 years of Michigan hockey. Talent coming out his ears that he displayed on nearly every shot; a useless slug without the puck. The former saw him score about a PPG for his career. The latter made Red scratch him on the regular despite the PPG thing. I thought that having Copp as his center would force him into something approximating defensive responsibility. This was not the case.
You can directly trace this season's failure to reach the tournament to Guptill cluelessly poking his stick in the general direction of a Penn State player he had every opportunity to stop from having a breakaway and did not. One Penn State goal later they were back in a game they would later win in OT. That specifically prevented Michigan from reaching the tournament and emblematically represented the lack of give-a-shit that characterized Guptill's career, an attitude that bled over into various other players on the team.
I'll miss that guy's hands. Not so much the rest of his game. Next year will be a fascinating test to see how extreme the anti-leadership emanating from the two departures was.
Exit Phil Di Giuseppe
[Adam Glanzman/Daily]
Winger Phil Di Giuseppe has signed with Carolina:
Michigan's Phil Di Giuseppe has signed with the Carolina Hurricanes, voiding his final year of eligibility.
— Michael Spath (@Spath_Wolverine) March 26, 2014
It's something of a blow to lose a senior-to-be who had a 13-11-24 line and some talent, but I'm putting together a post on the hockey team that inevitably looks at what they should have next year and it's obvious that Michigan was anticipating some attrition. PDG in particular was the subject of OHL rumors after his first year and never really seemed that into the whole Michigan thing.
Ah, hell. Might as well say it: whatever problems Michigan had that caused Red to say that this team had underachieved and it drove him nuts fall squarely on the scoring-line type wingers who were outpaced by Copp, Motte, and Compher not only in the scoring department but the defensive responsibility one. Unfortunately, Michigan doesn't have a Corsi stat or anything like that so your one potential indicator of defensive GAF is blocked shots. And that's pretty stark. Compher + Copp: 56. Moffatt + Guptill + PDG: 32.
Attempts at stats fail. The eyeball test had me groaning about giving a crap for large sections of the year. Whatever culture issues the team has seem centered in an older cohort, and I'm not sure losing them is much of a blow. And now I don't have to figure out how to spell his name 50 times a year.
Michigan is still waiting on a decision from Guptill; no one else seems like a likely departure.
One Frame At A Time: Wofford & Texas
Jordan Morgan recorded his second double-double of the weekend in the most Jordan Morgan way possible: by attempting to take a charge, not getting the call, and grabbing a board anyway while he's flat on his back.
This didn't make the top ten from the weekend. Don't fret, though—Morgan still makes several appearances. For the rest of the first two rounds of the tourney in GIFs, hit the jump.
[JUMP like GRIII over Javan Felix.]
Enter The Volunteer
Somewhere a Tennessee blog is posting a picture of Cato June chasing Jason Witten
So about that Kenpom rank. The good news for Michigan is that they've drawn an 11-seed in the Sweet 16. The bad news for Michigan is that they've drawn the incredibly rare team to have a Kenpom ranking well above their seed line—after their three-game run they are all the way up to sixth(!) in that rating system.
We talk a lot about Kenpom around these parts, but one of the things that's always seemed a little off about his rankings is how lopsided games have a disproportionate impact. Tennessee has had a lot of those. They've also lost 7 SEC games. They are 23-12. Is Tennessee really the sixth-best team in the country, or 11th as they were at the beginning of the tournament? Probably not. Ask Kenpom himself:
I'm not foolish enough to believe the Vols are the 11th-best team in the land (the Sagarin and Massey predictive systems both have Tennessee ranked in the mid-20s). But it's clear Tennessee, coached by Cuonzo Martin, is better than the typical No. 11 seed. It's also obvious the Vols are very difficult to evaluate based on the limited information available to us.
Tennessee is a weird team. It takes a weird team to blow out Virginia and outscore the SEC by 0.14 points a possession—Michigan, 15-3 Big Ten champ, only managed 0.09—and end up one of the last teams in the field because it went 11-7 in a conference that was fifth-best nationally and only had one team seeded above an 8.
When computers run up against weird teams, weird things get spit out. Kenpom's got an algorithm and he only changes it when he can find something that makes it more accurate over the ten seasons of data he's got, as he did when he tried out reducing the influence of blowouts in mismatches. (IE, he mitigated The Wisconsin Problem.) But there's not much you can do with a team that has a set of results as bizarre as the Vols.
Even if the algorithm is irrationally exuberant about the Vols it has to be given some credit for calling UT's outright domination of a higher-seeded UMass in the first round, and they would have given Duke all they would handle. Vegas, too, believes this is not a typical 11-versus-2 matchup, as they opened the line up at –1.5. Kenpom has the Vols by one. It's not a huge analytical difference. It's about which side of the coinflip you shade to. Tennessee may be an 11, but they're much better than their seed. Better than Michigan? Eh… we'll see.
And about that Texas comparison. It remains close. Similarities:
- Frontcourt size. Both Texas and Tennessee deploy two 6'8"+ guys at all times. The center is a widebody type, with a more athletic 4 man. Texas has way more post depth; Tennessee's starters are even better rebounders. PF Jarnell Stokes in particular is a McGary-level beast on the boards, 13th in OREB and 65th in DREB nationally.
- Board murderin'. Team OREB rates are near identical, with both teams acquiring almost 40% of their misses.
- Shooting issues. Tennessee is even worse from three than Texas is, but they shoot more. Go-to guy Jordan McRae is decent, as is Josh Richardson. Everyone else is bad. Tennessee's backups have combined to go 33/135 on the year; PG Antonio Barton is at 33%. Collectively the Vols are 282nd from deep.
- Passive defense. Texas and Tennessee both force few turnovers. Tennessee has a defensive profile a lot like a better Michigan: few FTAs, good rebounding, bad at forcing turnovers, Tennessee is a lot better at FG D.
- Backcourt size: Texas had no one who could reasonably contest jumpers from LeVert and Stauskas, with no one taller than 6'2" other than their posts. Tennessee goes 6'6", 6'6", 6'2" down the roster. They'll be a match for Michigan's size.
- Experience. Tennessee starts three seniors and two juniors. Texas starts three sophomores, a junior, and a freshman.
- Shot blocking. Tennessee doesn't do much of it, preferring to lock down the defensive boards and avoid fouls.
- Transition. Tennessee is a slow team, one that has fewer transition opportunities than Michigan and finishes them at a mediocre 55%. Texas tries to speed things up to help their bad half court offense.
- Depth. Texas has two solid bench players in Lammert and Martez Walker. Tennessee has a bunch of no-usage guys who don't do much more than eat minutes without bringing the world to a screeching halt.
- Preventing threes. Perhaps the most worrying issue for Michigan in comparison to Texas is that Tennessee doesn't give up many threes. That's not a schedule thing, either, as they were second in the league in that department. Texas gives up buckets of threes. This is not a fluke. Tennessee gave up buckets of threes in Bruce Pearl's tenure (best ranking in last three years of Pearl: 289th). When Cuonzo Martin arrived that number immediately plummeted and stayed there (worst ranking: 33rd).
So, yes, a version of Texas that is bigger and a lot better at playing fundamentally solid, unspectacular defense that prevents Michigan from deploying their #1 weapon as easily as the Longhorns did. Do not expect a laugher.
Maybe don't let Jordan McRae run at the rim. Unless the ref is going to give him a ridiculous tech.
McRae and Stokes can get up. Seems likely that LeVert will get McRae as Stauskas matches up with Josh Richardson. If I was Michigan I would be tempted to sag off Barton, the PG, to give other guys some help. Keeping Tennessee away from the rim is a top priority. Easier said than done with this defense.
Zone? Michigan tried a 1-3-1 against Texas to little effect and then dumped it. Tennessee also fits the profile of a team that might be vulnerable to zoning, what with their dodgy three point shooting. Michigan's problem in the 1-3-1 is that it hasn't forced threes in the last few games, it's forced Spike Albrecht to guard 285 pound guys. It kind of feels like the 1-3-1 extends itself too far, or allows too many passes that don't loop over the defense. Its rebounding issues are exacerbated when it's generating short rebounds, too.
A 2-3 might be effective, but Michigan hasn't spent much time on it or played it at all. Seems like this will be a man to man affair unless Michigan gets itself in desperation mode.


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College News
Student Receives Scholarship from Turnaround Management Association
On Thursday, October 25, JC Jones & Associates hosted the Turnaround Management Association's (TMA) Annual Student Night at St. John Fisher College. This marked the 11th year where up to five scholarships, ranging from $500 to $1,500, were awarded to students across Western New York. Mark Fancher '13, a current MBA student, was one of the scholarship winners.
Fancher graduated in May 2012 with a bachelor's degree in accounting. He immediately began his MBA degree and, upon completion, he plans to obtain his CPA license.
Fancher says he first learned about TMA when one of his professors recommended him for the scholarship because of his work ethic, motivation, and dedication. His additional qualifications of leadership potential and good communication skills were beneficial to him when applying for the scholarship.
"One of the greatest things I took away from the scholarship and TMA all together was the importance of networking and experience in the field," said Fancher.
Fancher also said that the scholarship has only strengthened his interest in accounting, and allowed him to better understand how different fields in business can come together and accomplish goals collectively as a team. Additionally, it reinforced his decision to seek his MBA degree because it enables him to network and gain real-world experience.
Recently, Fancher accepted a position at Ernst & Young in Syracuse, and is well on his way of climbing the ladder in the accounting field. He hopes to one day be a partner at a large accounting firm and be able to help companies across the world run more efficiently, be more transparent, and create better lines of communication.
TMA is the only international non-profit association dedicated to corporate renewal and turnaround management. Members are a professional community of turnaround and corporate renewal professionals who share a common interest in strengthening the economy through restoring corporate value back to organizations.
Check out photos from Fisher's 2015 Move In Day on Flickr!
Latest College News Stories
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- Checking the Box to Make a Difference
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- Melissa Bissonette Honored by Literacy Volunteers of Rochester
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- Fisher Communications/Journalism Alum Given Courage in Journalism Award
- Seven Presidents, 60 Years. Dr. Don Muench Reflects on Fisher's Fearless Leaders
- Journalism Students Work with Local News Station to Cover Rochester's Hidden Gems


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Thailand's geography and terrain are quite diverse: from the lush, jungle covered peaks of the northern mountains to the turquoise hues of the Gulf of Thailand. Exploring Thailand by air, whether skydiving or riding aboard a hot air balloon, glider, helicopter, or small aircraft allows visitors to have an exhilarating experience while getting a unique perspective on Thailand's spectacular countryside.
Phuket Tour Provider is the tour agent for the trip in 3 provinces - Phuket, Phang Nga and Krabi. We offer always a great trip with the best service to the tourist around the world.
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WASHINGTON (AP) — D.C. police say a city public school employee has been charged with enticing a minor.
Police say 26-year-old Joseph Morales was arrested after detectives got a tip about inappropriate communications between Morales and a student at Cardozo Education Campus, where he works.
Police got the tip on Thursday and Morales was arrested on Friday. The school system placed him on administrative leave.
Police say they investigation is continuing as they look for possible additional victims.
Cardozo is a secondary school serving grades 6-12 with an enrollment of 681 students.
A school system spokeswoman did not immediately return a message seeking comment.
A student at the school told WTOP, "That's surprising. He's one of the nicest dudes I know. He's helped me with my homework. I've played basketball and soccer with him. That's kind of crazy."
WTOP's Michelle Murillo contributed to this report. Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Sunken ships create a marine habitat full of fish, birds and other wildlife in Maryland.


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|Houff, Suzanne
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|1 online resource (97 p.)
In response to a quagmire of jargon based and convoluted curriculum textbooks, Instructional Alignment offers a concise and basic approach to instructional design. By exploring the areas of planning, assessment, and methodology, the text explains how these three areas provide an essential framework for effective teaching and illustrates how they align in order to maximize student learning.

Houff guides the reader through the process of developing objectives that identify what the learners should know and be able to do at the end of the lesson. Next, the readers study assessment strategies and tools that correlate with the stated objective in order to accurately determine if the objective has been met. Direct and indirect instructional strategies are then explored to provide the reader with a variety of options or methods to best meet the objective. Final alignment is demonstrated through a project-based unit example that provides a visual representation of theory into practice. With the concluding glossary of current trends and terms in instructional design, readers will finish this key guidebook with a thorough understanding of effective instruction, as well as the capacity to adopt methodical, tested, lessons in the classroom.

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London Enthusiast
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- Very comfortable sole
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- just something to be aware of - shoes narrow considerably at the front
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Published on: 24 September 2015
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