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ORBi Collection: Hematology http://hdl.handle.net/2268/103 The Collection's search engine Search this channel search http://orbi.ulg.ac.be/simple-search Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT) http://hdl.handle.net/2268/183675 Title: Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

Author, co-author: Mohty, M.; Malard, F.; Abecassis, M.; Aerts, E.; Alaskar, AS.; Aljurf, M.; Arat, M.; Bader, P.; Baron, Frédéric; Bazarbachi, A.; Blaise, D.; Ciceri, F.; Corbacioglu, S.; Dalle, J-H.; Duarte, RF.; Fukuda, T.; Huynh, A.; Masszi, T.; Michallet, M.; Nagler, A.; NiChonghaile, M.; Pagluica, T.; Peters, C.; Petersen, FB.; Richardson, PG.; Ruutu, T.; Savani, BN.; Wallhult, E.; Yakoub-Agha, I.; Carreras, E.

Abstract: Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children. Monoclonal antibodies against GARP/TGF-b1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo http://hdl.handle.net/2268/183672 Title: Monoclonal antibodies against GARP/TGF-b1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Author, co-author: Cuende, Julia; Liénart, Stéphanie; Dedobbeleer, Olivier; van der Woning, Bas; De Boeck, Gitte; Stockis, Julie; Huygens, Caroline; Colau, Didier; Somja, Joan; Delvenne, Philippe; HANNON, Muriel; Baron, Frédéric; Dumoutier, Laure; Renauld, Jean-Christophe; De Haard, Hans; Saunders, Michael; Coulie, Pierre; Lucas, Sophie

Abstract: Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function contributes to cancer progression by inhibiting antitumor immune responses. Tregs exert contact-dependent inhibition of immune cells through the production of active transforming growth factor–b1 (TGF-b1). On the Treg cell surface, TGF-b1 is in an inactive form bound to membrane protein GARP and then activated by an unknown mechanism. We demonstrate that GARP is involved in this activation mechanism. Two anti-GARP monoclonal antibodies were generated that block the production of active TGF-b1 by human Tregs. These antibodies recognize a conformational epitope that requires amino acids GARP137–139 within GARP/TGF-b1 complexes. A variety of antibodies recognizing other GARP epitopes did not block active TGF-b1 production by Tregs. In a model of xenogeneic graft-versus-host disease in NSG mice, the blocking antibodies inhibited the immunosuppressive activity of human Tregs. These antibodies may serve as therapeutic tools to boost immune responses to infection or cancer via a mechanism of action distinct from that of currently available immunomodulatory antibodies. Used alone or in combination with tumor vaccines or antibodies targeting the CTLA4 or PD1/PD-L1 pathways, blocking anti-GARP antibodies may improve the efficiency of cancer immunotherapy. Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation. http://hdl.handle.net/2268/183546 Title: Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation.

Author, co-author: Binsfeld, Marilène; HANNON, Muriel; Otjacques, Eléonore; Humblet-Baron, Stéphanie; BAUDOUX, Etienne; BEGUIN, Yves; BARON, Frédéric; CAERS, Jo Erythropoietin therapy after allogeneic hematopoietic cell transplantation has no impact on long-term survival http://hdl.handle.net/2268/183478 Title: Erythropoietin therapy after allogeneic hematopoietic cell transplantation has no impact on long-term survival

Author, co-author: JASPERS, Aurélie; Baron, Frédéric; SERVAIS, Sophie; LEJEUNE, Marie; WILLEMS, Evelyne; SEIDEL, Laurence; HAFRAOUI, Kaoutar; Bonnet, Christophe; Beguin, Yves Azacytidine prevents experimental sclerodermic chronic graft-versus-host disease http://hdl.handle.net/2268/183274 Title: Azacytidine prevents experimental sclerodermic chronic graft-versus-host disease

Author, co-author: Fransolet, Gilles; Ehx, Grégory; SOMJA, Joan; Belle, Ludovic; Drion, Pierre; Humblet-Baron, Stéphanie; Beguin, Yves; Baron, Frédéric

Abstract: Introduction: Graft-versus-host disease (GVHD) remains one major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Following unmanipulated peripheral-blood stem cell transplantation, 60% of the patients experience chronic GVHD while approximately 15% of them develop a sclerodermic form of chronic GVHD characterized by multiple organ fibrosis and loss of skin elasticity. Regulatory T cells (Tregs) play a pivotal role in the pathology of chronic GVHD by inhibiting alloreactive conventional T cells. Several studies have shown the hypomethylating agent Azacytidine (Aza) can demethylate the master transcription factor of Treg (Forkhead box protein 3 factor, FoxP3), thus promoting Treg differentiation of conventional T cells. This work investigates the impact of Aza in a classical murine model of sclerodermic chronic GVHD (B10.D2 BALB/cJ). Methods: Lethally irradiated BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107splenocytes from B10.D2 donor mice. Recipients were treated with subcutaneous injections of Aza at the dose of 0,5 or 2 mg/kg every two days from day 10 to 30 following transplantation. Mice GVHD was evaluated with five criteria (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 (or > 20% weight loss). Results: Mice treated with Aza 0.5 mg/kg (n = 14) or 2 mg/kg (n = 17) had significant lower clinical scores compared to control ones (n = 15) after treatment. FACS analysis showed a higher proportion of Treg among CD4+ T cells in the blood of Aza 2 mg/kg mice than in control mice (P = 0.047), as well as a higher percentage of Tregs expressing the KI67 proliferative marker on the same day (P = 0.0005). Finally, analyses of the cellular blood components with Cell-dyn demonstrated that Aza 2 mg/kg treated mice were significantly lymphopenic as compared to control mice (P = 0.05). Conclusion : Aza prevented sclerodermic GVHD in this classical murine model of chronic GVHD. Imatinib improves survival of chronic Graft-versus-host disease by inhibiting TGF-β and PDGF-R in mice http://hdl.handle.net/2268/183273 Title: Imatinib improves survival of chronic Graft-versus-host disease by inhibiting TGF-β and PDGF-R in mice

Author, co-author: Fransolet, Gilles; Belle, Ludovic; SOMJA, Joan; Humblet-Baron, Stéphanie; DUBOIS, Sophie; Delvenne, Philippe; Beguin, Yves; Baron, Frédéric

Abstract: Introduction: Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients develop the sclerodermatous cGvHD (scl-cGvHD) form of the disease characterized by multiple organ fibrosis and loss of skin elasticity. A few studies have suggested potential benefits of imatinib, a tyrosine kinase inhibitor, as a treatment of fibrosis in scl-cGVHD due to its ability to inhibit simultaneously the PDGF receptor and TGF-β pathways (via ABL inhibition), which are both involved in fibrosis . Aim: This work investigates the impact of imatinib on fibrosis in the B10.D2 to BALB/cJ scl-cGvHD murine model. Lethally irradiated BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107 splenocytes from B10.D2 donor mice. Recipients were treated with imatinib 150 mg/kg/day (50 mg/kg in the morning followed by 100 mg/kg in the evening) by oral gavage or the same volume of sterile water. Mice health status was evaluated with a scoring system encompassing five criteria (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 according to our local ethical committee. Results: Mice given daily 150 mg/kg imatinib had a better survival than control mice (42 versus 33 days, p = 0,0357). cGvhD scores were suggestively lower in imatinib-treated than in control mice (p ≤ 0,15). Further, histological analyses evidenced reduction in the levels of both PDGF receptor (p = 0,033) and c-Abl (p = 0,185) phosphorylation in imatinib as compared to control mice. Finally, no significant differences were observed in the number or frequency of lymphocyte subsets in the 2 groups of mice. Conclusion: Imatinib slightly decreased fibrosis and significantly improved survival in a severe scl-cGvHD murine model. Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy. http://hdl.handle.net/2268/182532 Title: Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.

Author, co-author: Onclinx, Cecile; Dogne, Sophie; Jadin, Laurence; Andris, Fabienne; Grandfils, Christian; Jouret, François; Mullier, Francois; Flamion, Bruno

Abstract: Hyaluronan is a major component of the extracellular matrix and glycocalyx. Its main somatic degrading enzymes are the hyaluronidases 1 and 2, none of which is active in the bloodstream. We generated hyaluronidase 2 deficient mice. They suffer from mild chronic anemia and thrombocytopenia, in parallel with a 10-fold increase in plasma hyaluronan concentration. The current study explores the mechanism of these hematological anomalies. The decreased erythrocyte and platelet counts were assigned to peripheral consumption. The erythrocyte half-life was reduced from 25 to 8 days without signs of premature aging. Hyaluronidase 2 deficient platelets were functional. Major intrinsic defects in erythrocyte membrane or stability, as well as detrimental effects of high hyaluronan levels on erythrocytes, were ruled out in vitro. Normal erythrocytes transfused into hyaluronidase 2 deficient mice were quickly destroyed but neither splenectomy nor anti-C5 administration prevented from chronic hemolysis. Schistocytes were present in hyaluronidase 2 deficient smears at a level of 1 to 6%, while virtually absent in control mice. Hyaluronidase 2 deficient mice had increased markers of endothelial damage and microvascular fibrin deposition, without renal failure, accumulation of ultra-large multimers of von Willebrand factor, deficiency of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motifs, member 13 (ADAMTS13), or hypertension. There was no sign of structural damage in hepatic or splenic sinusoids, or in any other microvessels. We conclude that hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice. The link between this uncommon condition and hyaluronidase 2 remains to be explored in man.

Commentary: Copyright (c) 2015, Ferrata Storti Foundation. The Sequence of Cyclophosphamide and Myeloablative Total Body Irradiation in Hematopoietic Cell Transplantation for Patients with Acute Leukemia http://hdl.handle.net/2268/182398 Title: The Sequence of Cyclophosphamide and Myeloablative Total Body Irradiation in Hematopoietic Cell Transplantation for Patients with Acute Leukemia

Author, co-author: Holter-Chakrabarty, Jennifer; Pierson, Namali; Zhang, Mei-Jie; Zhu, Xiaochun; Akpek, Görgün; Aljurf, Mahmoud; Artz, Andrew; Baron, Frédéric; Bredeson, Christopher; Dvorak, Christopher; Epstein, Robert; Lazarus, Hillard; Olsson, Richard; Selby, George; Williams, Kirsten; Cooke, Kenneth; Pasquini, Marcelo; McCarthy, Philip

Abstract: Limited clinical data are available to assess whether the sequencing of cyclophosphamide (Cy) and total body irradiation (TBI) changes outcomes. We evaluated the sequence in 1769 (CyTBI, n ¼ 948; TBICy, n ¼ 821) recipients of related or unrelated hematopoietic cell transplantation who received TBI (1200 to 1500 cGY) for acute leukemia from 2003 to 2010. The 2 cohorts were comparable for median age, performance score, type of leukemia, first complete remission, Philadelphia chromosomeepositive acute lymphoblastic leukemia, HLAmatched siblings, stem cell source, antithymocyte globulin use, TBI dose, and type of graft-versus-host disease (GVHD) prophylaxis. The sequence of TBI did not significantly affect transplantation-related mortality (24% versus 23% at 3 years, P ¼.67; relative risk, 1.01; P ¼.91), leukemia relapse (27% versus 29% at 3 years, P ¼ .34; relative risk, .89, P ¼.18), leukemia-free survival (49% versus 48% at 3 years, P ¼.27; relative risk, .93; P ¼ .29), chronic GVHD (45% versus 47% at 1 year, P ¼.39; relative risk, .9; P ¼ .11), or overall survival (53% versus 52% at 3 years, P ¼.62; relative risk, .96; P ¼.57) for CyTBI and TBICy, respectively. Corresponding cumulative incidences of sinusoidal obstruction syndrome were 4% and 6% at 100 days (P ¼ .08), respectively. This study demonstrates that the sequence of Cy and TBI does not impact transplantation outcomes and complications in patients with acute leukemia undergoing hematopoietic cell transplantation with myeloablative conditioning. High numbers of mobilized CD34+ cells collected in AML in first remission are associated with high relapse risk irrespective of treatment with autologous peripheral blood SCT or autologous BMT http://hdl.handle.net/2268/182397 Title: High numbers of mobilized CD34+ cells collected in AML in first remission are associated with high relapse risk irrespective of treatment with autologous peripheral blood SCT or autologous BMT

Author, co-author: Hengeveld, M.; Suciu, S.; Chelgoum, Y.; Marie, J-P.; Muus, P.; Lefrère, F.; Mandelli, F.; Pane, F.; Amadori, S.; Fioritoni, G.; Labar, B.; Baron, Frédéric; Cermak, J.; Bourhis, J-H.; Storti, G.; Fazi, P.; Hagemeijer, A.; Vignetti, M.; Willemze, R.; de Witte, T.

Abstract: The faster hematopoietic recovery after autologous peripheral blood SCT (APBSCT) in patients with AML may be offset by an increased relapse risk as compared with autologous BMT (ABMT). The EORTC and GIMEMA Leukemia Groups conducted a trial (AML-10) in which they compared, as second randomization, APBSCT and ABMT in first CR patients without an HLA compatible donor. A total of 292 patients were randomized. The 5-year DFS rate was 41% in the APBSCT arm and 46% in the ABMT arm with a hazard ratio (HR) of 1.17; 95% confidence interval = 0.85–1.59; P = 0.34. The 5-year cumulative relapse incidence was 56% vs 49% (P = 0.26), and the 5-year OS 50% and 55% (P = 0.6) in the APBSCT and ABMT groups, respectively. APBSCT was associated with significantly faster recovery of neutrophils and platelets, shorter duration of hospitalization, reduced need of transfusion packed RBC and less days of intravenous antibiotics. In both treatment groups, higher numbers of mobilized CD34+ cells were associated with a significantly higher relapse risk irrespective of the treatment given after the mobilization. Randomization between APBSCT and ABMT did not result in significantly different outcomes in terms of DFS, OS and relapse incidence. Etude de la reconstitution immunitaire après greffe de cellules souches hématopoïétiques : focus sur la fonction thymique et les lymphocytes T régulateurs http://hdl.handle.net/2268/182309 Title: Etude de la reconstitution immunitaire après greffe de cellules souches hématopoïétiques : focus sur la fonction thymique et les lymphocytes T régulateurs

Author, co-author: HANNON, Muriel

Abstract: L'allogre e de cellules souches hématopoïétiques, après conditionnement myéloalbatif ou non, est devenue une option de choix dans le traitement des maladies hématologiques malignes ou génétiques. Malheureusement le succès de ce traitement se trouve trop souvent entaché par des complications majeures telles que les infections ou la maladie du greffon contre l'hôte (GVHD), dans laquelle les cellules du donneur attaquent l'organisme du receveur. La reconstitution d'un système immunitaire fonctionnel, notamment via le thymus, est une étape clef dans la résolution de ces deux complications et l'utilisation de lymphocytes T régulateurs semble très prometteuse dans la lutte contre la GVHD. Le présent travail vise donc à étudier la reconstitution du système immunitaire après allogreffe sous trois angles différents, en nous focalisant sur la fonction thymique et l'influence des lymphocytes T régulateurs (Treg). Dans la première partie, nous évaluons la reconstitution immunitaire à long terme après greffe non-myéloablative et montrons que la néo-génération de lymphocytes T par le thymus s'effectue à partir du jour 100 chez les patients de moins de 60 ans alors qu'au delà de cet âge, elle est quasiment absente. Nous établissons également que la GVHD chronique (cGVHD) sévère possède des effets extrêmement délétères sur le thymus. Étant donné l'impact de la cGVHD sur le thymus et la reconstitution immunitaire, nous avons voulu comparer l'impact, sur ces deux paramètres, d'un conditionnement nonmyéloalbatif censé réduire la GVHD et composé d'une irradiation lymphoïde totale et d'anticorps anti-thymocytes (TLI-ATG) par rapport au conditionnement classique consistant en une irradiation corporelle totale associée à de la fludarabine (TBI-Flu). Il ressort de cette étude que, bien que réduisant de manière significative l'incidence de cGVHD, le conditionnement TLI-ATG altère fortement la reconstitution du système immunitaire et impacte négativement le taux de rechute/progression chez les patients traités. Enfin, toujours dans le but de réduire le taux de GVHD post-greffe, nous avons choisi d'examiner l'impact des Treg comme traitement de la xGVHD. Dans ce but, nous montrons qu'une sélection de Treg humains, sur CliniMACS par déplétion CD8/19 et sélection CD25, fournit une population de cellules enrichies en Treg capable de retarder de manière statistiquement significative l'apparition d'une GVHD xénogénique induite par injection de PBMC humains (autologues aux Treg) dans un modèle pré-clinique chez la souris NSG. De plus, lorsque injectée sans les PBMC, cette population enrichie n'induit pas par elle-même de GHVD.

Commentary: URN : ULgetd-01122015-163354 Azacytidine augments regulatory T cells and prevents experimental xenogeneic graft-versus-host disease. http://hdl.handle.net/2268/181721 Title: Azacytidine augments regulatory T cells and prevents experimental xenogeneic graft-versus-host disease.

Author, co-author: Ehx, Grégory

Abstract: The demethylating agent 5-azacytidine (AZA) has proven its efficiency in myeloid malignancies treatment. Recently, several studies have shown that AZA also presents an immunomodulatory activity, mainly through the induction of regulatory T cells (Treg) differentiation from conventional T cells. Treg promotion is a promising treatment option for graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. In this way, AZA has been shown to reduce GVHD in mouse-to-mouse transplantation models. However, the impact of AZA on human GVHD remains elusive as well as its effects on human Treg and on the other T cell subsets in vivo. Here we report AZA impact on GVHD in a xeno-transplantation model of the disease and describe the overall effects of the drug on human T cells in vivo. When administered to NSG mice receiving 2.107 human PBMC intravenously, AZA successfully ameliorated both survival (p < 0.001) and GVHD score. Flow cytometry analyses showed that this improvement may be mediated through an anti-proliferative effect of AZA on human T cells while these cells presented an increased activation state. We also observed a significant decrease of Th1 and 2 differentiation, assessed by RT-qPCR and cytokines secretion assays, and a reduced production of granzyme B and perforin 1 by cytotoxic T cells. As expected, AZA dramatically augmented Treg frequency while we could also observe a promotion of their IL-2 mediated proliferation over conventional T cells. Interestingly, Th17 frequency was not affected by AZA, therefore increasing the balance Treg/Th17. Finally our data suggest that AZA-induced Treg may have an improved suppressive activity and present long-term stability in vivo. Altogether our findings suggest that AZA may be a promising treatment option for GVHD in the clinical setting. Modification of standard ISHAGE methodology for CD34+ cells count on thawed Cord Blood Units: results from a multi-center Eurocord/Netcord study http://hdl.handle.net/2268/181650 Title: Modification of standard ISHAGE methodology for CD34+ cells count on thawed Cord Blood Units: results from a multi-center Eurocord/Netcord study

Author, co-author: Saccardi, RICCARDO; Azqueta, C; Ballerini, C; Ballerini, L; BAUDOUX, Etienne; Caporale, R; Dal Pozzo, S; Gomez, S; Kogler, G; Lanza, F; Angelotti, ML; Madrigal, A; Ongari, M; Querol, S; Radke, T; Rocha, V; Ruggeri, A; Urbani, S; Gluckman, Eliane Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning http://hdl.handle.net/2268/181279 Title: Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning

Author, co-author: HANNON, Muriel; BEGUIN, Yves; Ehx, Grégory; SERVAIS, Sophie; SEIDEL, Laurence; Graux, Carlos; Maertens, Johan; Kerre, Tessa; Daulne, Coline; de Bock, Muriel; Fillet, Marianne; ORY, Aurélie; WILLEMS, Evelyne; GOTHOT, André; Humblet-Baron, Stéphanie; BARON, Frédéric

Abstract: Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n=28) or 8 Gy TLI plus anti-thymocyte globulin (TLI arm, n=25). Results: In comparison to TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P=0.02), a higher incidence of CMV reactivation (P<0.001), and a higher incidence of relapse (P=0.01). While recovery of total CD8+ T cells was similar in the two groups, with median CD8+ T cell counts reaching the normal values 40-60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4+ T cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Further, CD4+ T cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T cell (Treg) counts were comparable in TBI and TLI patients, Treg/naïve CD4+ T cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens possibly explaining the different clinical outcomes observed (NCT00603954). Infusion of third-party mesenchymal stromal cells after liver transplantation: a phase 1, open-label, clinical study http://hdl.handle.net/2268/181117 Title: Infusion of third-party mesenchymal stromal cells after liver transplantation: a phase 1, open-label, clinical study

Author, co-author: DETRY, Olivier; VANDERMEULEN, Morgan; DELBOUILLE, Marie-Hélène; DE ROOVER, Arnaud; SOMJA, Joan; BLETARD, Noëlla; BRIQUET, Alexandra; LECHANTEUR, Chantal; BEGUIN, Yves

Abstract: Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases. Mesenchymal stromal cells (MSC) are multipotent and self-renewing bone marrow progenitors that have been shown both in vitro and in vivo as capable of (i) immunomodulation, (ii) anti-inflammation in case of ischemia/reperfusion injury, and (ii) stimulation of tissue repair. MSC could therefore be very interesting in organ recipients to limit chronic graft damage and to allow tolerance. This study aimed to be the first clinical evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled, phase I study. Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post- operative day 3 ± 2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients' immune function and on immunohistology of at month 6 graft biopsies. No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. This phase I study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. Quelle place pour le test de génération de thrombine au sein du laboratoire de biologie clinique? http://hdl.handle.net/2268/180424 Title: Quelle place pour le test de génération de thrombine au sein du laboratoire de biologie clinique?

Author, co-author: LECUT, Christelle; PETERS, Pierre; MASSION, Paul; GOTHOT, André AIRE polymorphism, melanoma-antigen-specific T cell immunity, and susceptibility to melanoma. http://hdl.handle.net/2268/180083 Title: AIRE polymorphism, melanoma-antigen-specific T cell immunity, and susceptibility to melanoma.

Author, co-author: Conteduca, Giuseppina

Abstract: AIRE which regulates T cell repertoire is involved in susceptibility to melanoma. Whether this role is mediated by melanoma antigen (MA)-specific T cell immunity is not known. In this study, we have tested this possibility, taking advantage of the structural and functional homology of human AIRE and MAGE with their mouse counterparts. AIRE and MAGEB2 expression was measured by real time PCR in medullary thymic epithelial cells (mTECs) from two strains of C57BL/6 mice bearing selectively one of the two (T or C) allelic variants of rs1800522 AIRE SNP. The extent of apoptosis induced by mTECs in MAGEB2-specific T cells and the susceptibility to in vivo melanoma B16F10 cell challenge were compared in the two mousestrains. The C allelic variant, protective in humans against melanoma, inducedlower AIRE and MAGEB2 expressionin C57BL/6 mouse mTECsthan the T allele. mTECs from the strain bearing the AIRE CC genotype induced lower extent of apoptosis in MAGEB2-specific syngeneic T cells than mTECs from the strain bearing the TT genotype (P<0.05). Vaccination against MAGEB2 induced higher frequency of MAGEB2-specific CTL and exerted higher protective effect against melanoma development in mice bearing AIRE CC than in those bearing the TT genotype (P<0.05).These findings show that alternative allelic variants of one AIRE SNP may differentially shape the MA-specific T cell repertoire potentially influencing susceptibility to melanoma. AIRE polymorphisms induce variable extent of apoptosis on melanoma-specific CD8+ T lymphocytes. http://hdl.handle.net/2268/180082 Title: AIRE polymorphisms induce variable extent of apoptosis on melanoma-specific CD8+ T lymphocytes.

Author, co-author: Conteduca, Giuseppina AIRE polymorphisms induce variable extent of apoptosis on melanoma-specific CD8+ T lymphocytes. http://hdl.handle.net/2268/180081 Title: AIRE polymorphisms induce variable extent of apoptosis on melanoma-specific CD8+ T lymphocytes.

Author, co-author: Conteduca, Giuseppina

Abstract: AIRE regulates thymocyte selection by inducing the expression of tissue-restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs). MAGE antigens are among TRAs regulated by AIRE. Single nucleotide polymorphisms (SNPs) of AIRE gene have been reported in humans but their impact on repertoire selection of tumor antigen-specific T lymphocytes is unknown. We report here that the rs1800522 SNP of human AIRE gene is present in mice and that the relative T or C allelic variants differently regulate MAGEB2 gene expression in mTECs. The C allelic variant, protective in humans against melanoma, induces lower MAGEB2 expression than the T allele. When mouse mTECs bearing the TT genotype were gene targeted to substitute the T with the C allelic variant, the co-culture of wild type or transgenic mTECs with MAGEB2-specific syngeneic T cells induced reduced extent of apoptosis and increased frequency of MAGEB2-specific viable T lymphocytes in T cells cultured with mTECs bearing the CC with respect to the TT genotype. These findings demonstrate that alternative allelic variants of AIRE SNPs may differently modulate the T cell repertoire specific against melanoma cells and subsequently may be linked to a different level of suceptibility to a neoplastic disease such as melanoma. Flow Cytometry Assessment of CD34+ Viability in Thawed Cord Blood Units: A Multi-Center Eurocord and Netcord Study http://hdl.handle.net/2268/179915 Title: Flow Cytometry Assessment of CD34+ Viability in Thawed Cord Blood Units: A Multi-Center Eurocord and Netcord Study

Author, co-author: SACCARDI, RICCARDO; AZQUETA, Carmen; BALLERINI, Lara; BAUDOUX, Etienne; DAL POZZO, Simone; GOMEZ, Susana; KOGLER, Gesine; LANZA, FRANCESCO; ONGARI, MANUELE; QUEROL, Sergio; FALK RADKE, TEJA; ROCHA, Vanderson; RUGGERI, Annalisa; URBANI, SERENA; GLUCKMAN, Eliane Long-term safety follow-up of a randomized trial of darbepoetin alpha and intravenous iron following autologous hematopoietic cell transplantation. http://hdl.handle.net/2268/179794 Title: Long-term safety follow-up of a randomized trial of darbepoetin alpha and intravenous iron following autologous hematopoietic cell transplantation.

Author, co-author: JASPERS, Aurélie; Baron, Frédéric; Maertens, Johan; DE PRIJCK, Bernard; Schots, Rik; Bonnet, Christophe; HAFRAOUI, Kaoutar; WILLEMS, Evelyne; SERVAIS, Sophie; FILLET, Georges; Beguin, Yves


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Unborn and still nameless, Andrea Hiatt's baby boy did mommy a big favor by holding out past his due date of Feb. 14 for Thursday's big game against crosstown rival East Union.
All of the extra batting sessions, fielding drills and even the blisters on her hands have finally paid off for East Union High senior Cherie DeJesus. She signed her letter of intent to become a student-athlete for Central Arizona College Thursday.
The Weston Ranch girls basketball team did its part.
RIPON - While powerhouse Modesto Christian capped yet another dominant run through the Trans Valley League for its fourth straight title, Ripon High's girls basketball team can find solace in going undefeated against the rest of the conference's opposition.
After narrowly losing to Valley Oak League sophomore girls champion Sonora at home Tuesday, Manteca moved into a second-place tie with rival East Union with its season-ending 40-24 on the Squires' home floor Thursday.
SONORA – With just under two minutes to play, Gerry Cooper calmly sank a pair of free throws to push the Manteca High varsity basketball team up by two and the Buffaloes would hold off Sonora High for a 68-64 Valley Oak League win Wednesday.
Alex Nuanez's march for redemption continues Friday and Saturday with the Sac-Joaquin Section Division IV Tournament at East Union High.
Tyler Bylow was one of six seniors to take the court for the East Union Lancers on senior night, but Bylow shined brightest with a huge 22-point effort against the winless Lathrop Spartans in a 64-41 Valley Oak League win Wednesday at the Dalben Center.
CERES – Bret Wilson led a balanced Sierra High scoring attack in its Valley Oak League win over the Central Valley Hawks Wednesday.
There is much more than bragging rights riding on Thursday's rubber match with rival East Union.
Manteca High's boys basketball team stretched its first-place lead while clinching its second straight Valley Oak League championship by beating second-place Sierra 66-49 Friday, but that did not improve its position on the Sac-Joaquin Section Division III playoff power ratings.
RIPON - Ripon Christian had the right guy at the right spot with the game still on the line with 3 seconds left against host Ripon.
RIPON – Ripon Christian's varsity girls basketball team fought off every blowout attempt that visiting rival Ripon threw its way, yet the Knights could not fight off their second Trans Valley League loss to the Indians in a 60-46 defeat Tuesday.
LATHROP – The Lathrop Spartans had one last opportunity to record their one and only win of the Valley Oak League season, but even a valiant fourth quarter effort could not help Lathrop earn its first victory in a season-ending 52-48 loss to East Union Tuesday.
Even with the Valley Oak League sophomore girls basketball title already wrapped up, Sonora High wants to close its season on a high note.
Page 282 of 345
Bulletin staff reports
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Keep track of "Emma".
|Emma Full Movie
|A housekeeper faces unexpected snobbery when she marries her boss in this enjoyable drama starring Oscar-nominee Marie Dressler and Jean Hersholt. Co-starring Myrna Loy.
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Cache Logical PartitionA Cache Logical Partition (CLPR) defines the assignment of a specific data cache allocation and the assignment of one or more parity groups assigned to that cache allocation. [Source: Sun StorEdge White Paper]
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
From wacky alarm clocks to lecture hall tools and after class entertainment, these Android apps are a good fit for a student's life and budget. Read More »Sharing Threat Intelligence
A growing number of startups make the sharing of threat intelligence a key part of their solutions. Read More »Smiley Faces and Symbols
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Narrow your search
With its titanium, leather and sapphire body and whopping price tag, the Vertu New Signature Touch may be the most luxurious Android phone around.
Pricing not available
Looking for phones? CNET editors' reviews of the best phones include product photos, video, and user reviews.
The 3DS XL's improved 3D head-tracking is a big step up and its performance boost more makes a noticeable difference. A few head-scratching design choices prevent us from falling for the New 3DS XL, but this is still the best Nintendo portable to get.
Nintendo's New 3DS isn't much improved overall, but that new display alone almost makes the purchase worthwhile -- or will do, once it's available outside of Japan.
From CNET Magazine: Smartphones, online services and biometric scanners are already easing the way for travelers. Expect even more tech to transform your journeys in the not-too-distant future.
Job No. 1 for the new CEO: Revamp the stagnating microblogging service to make it more inviting for regular folks.
Commentary: Back in June, I signed up for Apple Music, eager to make it my one-and-only music service. But after just a few weeks, I jumped ship for Spotify. Here's why.
Technically Incorrect: In the workplace, millennials have become entitled to a mocking. It's surprising that it's taken "Saturday Night Live" this long to join in.
With just the right amount of brutality and craziness, Wolfenstein: The New Order is a genuine good-old Nazi-killing time.
Using technology called carbon nanotubes, Big Blue takes a significant step on a years-long path to secure the computing industry's future as today's chipmaking technologies run out of steam.
Need to protect your iPhone 6/6S or iPhone 6 Plus/6S Plus? A slew of cases are available, with new cases arriving weekly. Here are our current top picks.


text:
Slepyshev earns final Oilers roster spot; Draisaitl to AHL
The Edmonton Oilers have assigned center Leon Draisaitl to AHL Bakersfield.
The demotion of Draisaitl, 19, means 21-year-old rookie Anton Slepyshev has made the opening-day roster after scoring twice and adding two assists in exhibition action.
The Oilers experimented during the preseason with Draisaitl, a natural center, on the wing. He didn't have a particularly poor camp, finishing with one goal and three assists in six games.
But Slepyshev apparently impressed more.
"He's a young player but he's played pro hockey before," coach Todd McLellan told the Edmonton Journal. "You can see it."
Slepyshev played 58 games in the KHL last season, scoring 15 goals for Salavat Yulaev Ufa.
Canucks roll the dice on rookies, waive Vey and Corrado
A preseason push by a number of Vancouver Canucks youngsters has left forward Linden Vey and defenseman Frank Corrado on waivers today.
The more surprising name of the two is Corrado, the 22-year-old who entered the season with an excellent chance of making the opening-day roster. However, it seems that rookie d-man Ben Hutton, 22, has been given the nod after finishing an eye-opening preseason with one goal and four assists in seven games. (This despite Hutton being waiver exempt. So it's a risk for the Canucks, to be sure.)
It was the play of 19-year-old rookie Jared McCann that led, in part, to the waiving of Vey. (For more on that, click here.) Veteran Adam Cracknell remains with the team as well, to some surprise.
Rookie winger Jake Virtanen is also expected to be on Vancouver's opening-day roster, though that's no big shock.
Defenseman Alex Biega is also on waivers, as expected.


text:
Cleverly constructed with molded cups and adjustable straps, Shock Absorber's moisture-wicking sports bra is a perfect fit for the active fashionista. Wear this high-performance design alone or layered under a T-shirt for a cool foundation to all your workout looks.
Red and blue polyester-blend Padded cupsAdjustable shoulder straps, keyhole backHook fastenings54% polyester, 41% polyamide, 5% elastaneMachine wash
Product code: 195133 - Need help? Contact us


text:
You couldn't have more of a status quo vote than McCain and Clinton.
You couldn't have more of a status quo vote than McCain and Clinton.
Obama won among people who feel like the economy is doing well and Hillary won among those who disagreed. Obama won among college graduates, Hillary won among those who didnt graduate college. If this pattern persist, Obama will lose. Mondale/Hart. […]
Holy Moly. Evangelicals made up 21% of the New Hampshire Republican voters — and went 32% for Huckabee and 31% for McCain, who was supposedly loathed by religious Christians. Exhibit #838 that we need to recalibrate our understanding of evangelical […]
Everyone is assuming that Huckabee's only chance is down south in the Bible belt. But before they get to South Carolina, where he should do well, they hit Michigan. We don't tend to think of Michigan as an evangelical state […]
But it's not all Obamania Secretary of State William Gardner has predicted 260,000 Granite Staters will vote in the Democratic primary and 240,000 will vote in the Republican primary. He predicted that 150,000 undeclared voters will cast votes – 90,000 […]
Obamania! So, tell me how the Republicans win against this in November? From Drudge: Secretary of State is making runs to Seacoast – Hampton, Portsmouth – and Southern Hillsborough – Pelham, Nashua – to bring extra democratic ballots. Many towns […]
I guess his "top immigration surrogate" didn't speak for him: Gov. Mike Huckabee has issued the following comment in response to a Washington Times article reporting he would amend the Constitution in connection to children born in the U.S. to […]
It looks like it according to his "top immigration surrogate" Mike Huckabee wants to amend the Constitution to prevent children born in the U.S. to illegal aliens from automatically becoming American citizens, according to his top immigration surrogate — a […]
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posted 11:35:03am Nov. 07, 2008 | read full post »
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The Party Platforms: Instructive Guides to Informed Voting - Part 3
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text:
Wouldn't you love Álex González to demonstrate this for you?
Men's clothing brand Dockers® (part of Levi Strauss & Co.) held quite the classy event on June 19, Dockers® Flannels for Heroes, a day-long cricket match at Burton Court.
(L to R) British actress Vera Day, 79, and Gun Crazy (1949) actress Peggy Cummins, 89
This was the second year the brand sponsored the event, which was in support of veterans' charities.
(L to R) González, Day & Barış Kılıç
From a press release:
All proceeds from the Dockers® Flannels for Heroes event will support two charities with the same mission to improve the lives of service men and women and their families. Walking With the Wounded (HRH Prince Harry joined Dockers® brand ambassador Jaco Van Gass on a trek to the South Pole in 2013), which retrains and re-skills servicemen to help them find new careers following duty cut short; and Combat Stress, which has for past 95 years helped UK veterans and their families suffering from depression, anxiety and PTSD following departure from the armed services.
At Levi Strauss & Co., giving back is part of the company's DNA. Powered by the pioneering spirit that goes all the way back to its founder, Levi Strauss, the Dockers® brand under the umbrella of Levi Strauss & Co. is always seeking ways in which it can make an impact. That's one of the reasons the Dockers® brand was proud to support Flannels for Heroes last year, and why the brand chose to return as sponsors in 2015.
Keep reading to see more of the dapper attendees ...


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Mississauga, ONCanada
June 24, 2013
I am a sculptor using silicon bronze. I also paint in water color still life as well as oil painting. I also sketch portraits in charcoal 7 pencil drawings.
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text:
Welcome to the Diamond Edge Figure Skating Club!
It is our mission to provide programs that encourage personal growth and a lifelong commitment to physical fitness through the art and sport of figure skating!
Classes started in Willmar on Sunday, October 11 for Basic 4 Skaters and above and will start on Sunday, October 25 for Snowplow - Basic 3 and New Skaters.
DEFSC offers Group Basic Skills lessons for skaters learning to skate, and also private lessons for skaters in the upper Basic Skills Curriculum and those who have advanced beyond. We welcome skaters from all communities in our surrounding area. Currently, DEFSC is providing instruction to skaters in five different school districts.
Classes are offered on Sundays afternoons, Monday evenings and Thursday evenings. Registration forms are available to download from this website. Please mail your registration form to Diamond Edge FSC, P.O. Box 204, Willmar, MN 56201.
Upcoming Events (view calendar for more detail)
Paynesville Ice Schedule is now available! View Paynesville Schedule
Willmar ice will start for Basic 4 and above on Sunday, October 11th.
Willmar ice will start for New Skaters thru Basic 3 on Sunday, October 25th.
Registration for Willmar Ice is Now Available!!! View Registration Forms
We have a new email address - Please email us at email@example.com.
It's Great to Skate Open House - Sunday, October 18th from 12:45-1:45 pm at the Willmar Civic Center.
WRAC 8 filmed some highlights of our show for their "Did you Know" segment. View Segment
Diamond Edge Figure Skating Club
PO Box 204
Willmar, MN 56201
Web Design by Dennis Benson


text:
Stainless Steel Cart For Large Big Green Egg Ceramic Grills
Earn 3,000 myRewards points
Reg: $1,299.99|
- Item ID #
- 2532792
- Model #
- SS-Kamado-Top-Universal + SS-Kamado-Cart
- Showcase and securely support your Big Green Egg kamado-style grill
- Commercial grade 304 stainless steel construction
- Fold-down side shelves provide workspace to prepare food near your grill
- Door and drawers provide storage for your BBQ tools and accessories
- Made in U.S.A.
- Width
- 65 1/4 inches
- Height
- 34 1/4 inches
- Depth
- 30 1/4 inches
Full DescriptionThis Stainless Steel Grill Cart is designed to house Large Big Green Egg ceramic charcoal grills. The grill cart is made in America and constructed of commercial grade 304 stainless steel. The cart features a door with a fully enclosed cabinet and two drawers which provide storage for all of your grilling tools and other essentials. The fully extendable drawers have heavy-duty ball bearing drawer glides to glide out smoothly. Two large side shelves offer a prep area close to your grill, with one featuring a towel bar and a removable cutting board. The shelves can be folded down or removed to save space when not in use or to insert the cart into an island. Four caster wheels (2 fixed and 2 swivel) allow you to easily move the grill when needed. Fully welded and blended corners and a brushed, satin-like finish add a professional finishing touch to the grill cart, making it the perfect complement to your Big Green Egg kamado. Overall Dimensions (in inches): 65 1/4 W (with side shelves up); 41 W (with side shelves down) x 34 1/4 H x 30 1/4 D. Inside door measurement: 18 1/4 W x 29 D x 16 H. Inside drawer measurement: 15 1/4 W x 18 1/2 D x 6 H per drawer. Side shelves: 14 W x 30 1/4 D. Cutting board: 12 x 18. Shelf handle adds 2 1/2 inches in depth to right shelf measurement. Patent Pending. Must use the ceramic feet included with your kamado grill.
Item Type Kamado Cart Grill Type Charcoal Grills Accessory Type Grill Part Collection Big Green Egg
Overall Dimensions
Height 34 1/4 Inches Width 65 1/4 Inches Depth 30 1/4 Inches
* Some orders received will go through our fraud prevention department. If your order is selected, you will be notified and your order may be delayed up to three (3) additional business days.
Shipping PriceFree Shipping ( Read Our Simple Shipping Policy ) Ship Time*Ready to Ship In 24 Hours
Height: 34 1/4 Inches Width: 65 1/4 Inches Depth: 30 1/4 Inches View More Specifications
The Big Green Egg Collection
Customers Also Bought
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Customer Reviews
- Item Reviewed
- Stainless Steel Cart For Large Big Green Egg Ceramic Grills
- Average User Rating
- (4 Reviews)
Great Cart and Even Better Customer Service.
I have had this cart for about 2 years and it still looks great. I ran into a fellow Komodo cooker today and recommended this product and decided to write a review while i went to the site to send this person the link to BBQ Guys. Service is impeccable. My order came on the 4th day after ordering. They accidentally sent me the XLG when i wanted the large. I called and there were profuse apologies and they shipped the correct cart without making me pack up and ship the wrong one and wait till they received it like other companies do. In addition they said they would ship me the right one that day!!! and i got it within three days! Also, dig this . . . they even sent someone to pick up the wrong cart - that sealed the deal with me as far as wanting to do more business with them! The cart is very well packed, VERY BIG box and just plumb pleased with the quality of this cart. It still washes up well, shines and looks quite professional. I do NOT cover it up - but i do keep it under my patio roof not in the elements. Again, wanted to write a review that is well past its time and refer a new customer to them. PS: Love the cutting board that is on the right hand pull out shelf. Casters on the legs make it even better as i can move the table if i want. I have just bought another Komodo unit and i plan on purchasing another one of these carts. BBQ Guys rock.
Great product
We just received our SS Big Green Egg cart from BBQ guys. Awesome product, well wrapped and it arrived less than a week from date of order. Quality is better than I expected. Thank You.
Stainless Steel Large Big Green Egg Cart
I just purchased this cart less than a week ago. I called the customer service number to order and they were incredibly professional. The cart arrived in less than 4 days, the delivery crew was excellent, the product was packaged and wrapped unbelievably, it was very easy to set up, is high quality. I am very impressed with this cart, the packaging, the customer service, and the overall purchase from this site. I would definitely recommend purchasing this cart and this website. Very pleased.
Deluxe & functional stainless work cart for Green Egg grill
We are very pleased with the stainless grill cart for our large Green Egg. The high quality of materials and construction is impressive, particularly the drawers and door. Good amount of storage space and workspace. There is a seam in the top where the front & back halves of the top fit together, which was hard to see in the product photos. The drop down shelves give plenty of work room, although we ordered a solid right shelf in case we want to replace the one with the cutting board. Casters make it easy to move. The Egg does sit higher in this cart than the wood tables made for the Egg, although my husband is 5'9" and it doesn't bother him. There is really no assembly involved - it arrived in a large box on a wrapped pallet with no damage. The Customer Service team has been wonderful to work with and expedited our missing towel bar. We would definitely order from this company again.


text:
Marvin Harrison Shot At in Philadelphia
According to David Gambacorta of Philly.com's Daily News, former NFL Pro Bowler Marvin Harrison was shot at around 3:20 am Saturday morning in North Philadelphia. Apparently Marvin was driving his Ford F-350 pickup truck through a neighborhood when a 38 year old man flagged him down wearing just his boxers. The naked man was frantic and asked 41 year old Harrison to call 9-1-1 because two intruders just broke into his apartment.
The former Indianapolis Colts star wide receiver, who played for the team for thirteen years, then allowed the man to climb into the bed of the truck before the burglars came after them both. One of the men fired twice and bullet struck one of Marvin Harrison's truck tires while they were trying to flee the area. Neither Harrison or the unknown victim were injured during the incident.
The victim told the Daily News that the burglars stole about $500 in cash from the apartment and Marvin could not be reached for a comment. This is not the first time that Marvin Harrison has been in the news for reasons other than football. He has been accused of shooting two men in 2008 but both of them ended up being gunned down before any legal actions were taken. Then in 2010 he was stopped for driving the wrong way on a one-way street and police found a 9mm handgun in his car. Charges were never filed in that case either.
It seems that trouble find Marvin Harrison wherever he goes. Hopefully he can clean up his reputation and he will not be known for these types of happenings.
Sports-Kings Down and Distance Contributor Kyle Pierce @kylepierce28


text:
ZnDiy-BRY RF DC12V 1CH Learning Code Remote Control Switch w/ Controller - Black + Silver
Model: 12-1B Quantity: 1Piece Color: Black + Silver Material: PCB + Plastic English Manual Spec: No Other Features: Channel: 1CH; Radio Frequency: 315MHz 433MHz
free shipping
(1 Review)
» Switches & Adapters
Add To Cart
ZnDiy-BRY DC 12V 4-CH Learning Code Remote Control Switch Kit
Brand: ZnDiy-BRY Model: 12-4B Quantity: 1Piece Color: Black Material: PCB + Plastic English Manual Spec: No Other Features: Channel: 4 CH;
Radio Frequency: 315MHz 433
E27 3W 180lm 1-LED RGB Light Lamp w/ Remote Control - Purple + Silver (AC 85~265V)
: 510nm B: 460nm Other Features: Widely used in jewelry counter, wine holder, store, exhibition counter, hotel, bar, club, western restaurant, home, cafe, KTV, party and
(0 Review)
SDV-5G9 0.83" LCD 5.0 MP CMOS Sport Diving DVR Camcorder w/ RF Remote Controller, Wi-Fi, TF - Black
seconds where the time is measured from start of picture to start of picture ; Auto power off: 60s 120s 300s Off; RF Wrist strap remote controller battery: 1 x 3V CR2032
» Sport Cameras
Hesunse Y-C3E 3-Way Wireless Digital Remote Control Switch Silver + Red (180~250V)
white line, full brightness; Remote control function: "A, B, C" key on the remote control corresponding to each group can be independent on or off, press and hold the "ON OFF
CAM AT200 1.5 TFT Screen 50M Waterproof 1080P Full HD 5.0MP CMOS Remote Control Wi-Fi Sports Camera
Mobile device OS: iOS 6.1 or above, Android 4.0 or above,
Remote controller frequency: 6 meter, Wireless remote distance: 15meters in open space
Replacement Plastic Back Cover for Wireless Wii U / Wii Right Controller Battery - White (2 PCS)
become lost. Unfortunately, if that item that has been broken or misplaced is the battery cover on the Wii remote, it can make the game system virtually unplayable
» Controllers Attachments
B Type 21-in-1 Accessories Bundle Kit for GoPro - Black
Color: Black Quantity: 1Piece Material: ABS Shade Of Color: Black
» Other GoPro Accessories
ZAP ZAP-S6 Android 4.2 Google TV Player w/ 1GB RAM, 8GB ROM, Bluetooth, TF, HDMI - White + Black
Capacity: 64GB Supports Card Type: MicroSD TF External HDD: 2TB Internal HDD: No Wi-Fi: 802.11 b g n Bluetooth Version: V3.0 3G Function: No Wireless Keyboard Mouse: IEEE8021.11
» Smart TV Players
MOCREO Micro USB 1080p MHL to HDMI Adapter Cable for Samsung/ HTC/ other Smart Phone with MHL Port
, Turns your phone's USB-port into a standard HDMI port, Use the TV's remote to control and access content on your phone, Keeps your phone charges while connected Other
(6 Reviews)
» A/V Adapters & Converters
300KP Wireless Wifi/WLAN Network Surveillance IP Camera w/ 10-LED Night Vision/Microphone
,36,64-channel no user limited centralized monitor remote record and playback Skype message alarm skype telephone alarm meeage alarm etc Superiority: Support multi-channel
» IP Cameras
300KP CMOS Network Surveillance IP Network Camera w/ 13-LED Night Vision - Black
Other Easy Install, high-definition video image, monitor two-way voice ; Remote control camera by wireless WAN and internet; Motion detect video record, image missing alarm
Rubik Cube Style 720P CMOS 1.3MP 10-LED P2P Network IP Camera (US Plug)
grades encrypt permissions
Upgrade: remote one-key- upgrade through network
Resetting: intelligent system self repair function
Alarm channel: 1 alarm input channel, and 1
Ontop 720P CMOS 1.0MP P2P Network IP Camera - White
Ethernet interface;
Picture rotation: mirror inversion
Supports video control;
Supports two-way voice;
Motion detect: 3 motion detect districts, max
Alarm action: external alarm
KNK KNK-380 0.3MP CMOS IR Night Vision WiFi IP Camera w/ Free DDNS
run motion detection; with 3 authorization classification; supports long distance view and control with the built-in network server; visit access: WEB centralized
Bikeman YKWB1018 Bicycle Remote Control Signal Light Indication Holder Tail Bag - Red + Grey
.5L Waterproof: Yes Type: Tail bag , Reflective Gears Other Features: Wireless Frequency: 2.4GHz; Remote distance: 3M; Transmitter: Battery: 2 button batteries; Housing
» Bike Accessories
NW-S-G011 Mini Red / Green Laser Stage Lamp w/ 10 Blue LEDs / Remote Controller
~240V power adapter 150cm 1 x Holder 1 x Chinese English manual 1 x Remote controller 1 x CR2025 included
» Stage Lights
XL-M-069 4-in-1 Stage Lighting Projector MP3 Player Speaker w/ USB / SD / Remote Controller / Tripod
III B; Work mode: Sound control + Auto mode; Supports SD card and U Disk up to 16GB; Used for Family parties,XMAS decoration ,Bar,Disco,KTV,Festival; Come with Remote
XL-M-D09 Stage Light Projector MP3 Player Speaker w/ USB / SD / Remote Controller / Tripod - Black
Certification CE Packing List 1 x Laser projector 1 x AC power charger adapter 2-flat-pin plug 110cm-cable 1 x Tripod holder 1 x Remote controller 2 x AAA batteries, not included 1 x
XL-M-03 4-in-1 Stage Lighting Projector MP3 Player Speaker w/ USB/ SD/ Remote Controller / Tripod
Controller,can be control the music; Certification CE Packing List 1 x Laser projector 1 x Power adapter 2-flat-pin plug 110cm-cable 1 x Tripod holder 1 x Remote Controller 2x AAA
7" LCD Portable Camera Field Monitor w/ HDMI / BNC / RCA
- Accessories:
- 1 x Remote controller 1 x CR2025 included
- 1 x Sun shade
- 1 x Hot shoe adapter
- 1 x HDMI cable 40cm
- 1 x Iron holder
- 1 x Battery station
- 1 x
» Other Accessories
CJSJ CR-13B Resettable 3-Digit Number Combination Lock - Blue + Silver
Material Copper zinc alloy Brand CJSJ Model CR-13B Color Blue + silver Quantity 1 Remote Controlled distance 0 Voice Decibels 0 Power Supply 0 Battery Type 0
» Other Security Products
CJSJ CR-10B Resettable 3-Digit Number Combination Lock - Silver
Material Copper zinc alloy Brand CJSJ Model CR-10B Color Silver Quantity 1 Remote Controlled distance 0 Voice Decibels 0 Power Supply 0 Battery Type 0 Certification 0
CJSJ CR-21B Resettable 3-Digit Number Wire Number Lock - Silver + Black
Material Copper zinc alloy Brand CJSJ Model CR-21B Color Silver + black Quantity 1 Remote Controlled distance 0 Voice Decibels 0 Power Supply 0 Battery Type 0
CJSJ CR-25B Resettable 3-Digit Number Combination Lock - Yellow + Silver
Material Copper zinc alloy Brand CJSJ Model CR-25B Color Yellow + silver Quantity 1 Remote Controlled distance 0 Voice Decibels 0 Power Supply 0 Battery Type 0
CS-141B 14.1" LED Digital Photo Picture Frame Album w/ Play Music / Video / Speaker - Black
photo frame 1 x AC power charger adapter 150cm-cable EU plug 1 x Remote control 1 x CR2025 battery, included 1 x Holder stand 1 x English user manual
» Digital Photo Frames
VSTARCAM F6836W Indoor Surveillance Security IP Network Camera with 10-LED IR Night Vision - Black
version, firefox, chrome, safri Super Client 1, 4, 9, 16, 25, 36, 64, 81-channel , no user limited , centralized monitor, remote record and playback , Skype message alarm
(29 Reviews)
KD-7099 7" Android 4.2.2 Dual-Core 3G Car DVD Player w/ 1GB RAM / 8GB Flash / GPS / Wi-Fi for VW
, iPod playing , Remote Control , TV , AV-IN , Steering Wheel Control Compatible Make: VW Compatible Car Model: PASSAT B5 Golf 4 Polo Bora Jetta Sharan T5 1999-2005 Compatible
» Car DVD Players
VSTARCAM T7838WIP 720p 1.0MP Wireless Network IP Surveillance Security Camera w/ 12-IR LED - White
; 14916253664 81-channel centralized monitoring system centralized monitoring remote video remote video playback SMS and other alarm methods; PnP server cluster is all over the world
(4 Reviews)
TF-361 16-CH Wireless Flashgun Trigger for Canon EOS DSLR
- Model: TF-361
- TF-361 is a wireless Flashgun remote control for Canon Camera
- FSK modulation used to improve the reliability and stability of the product, use the
(3 Reviews)
» Camera Remotes
300KP Wireless WiFi Network Surveillance IP Camera w/ 12-LED Night Vision/Microphone
- WiFi: 802.11b g n
- Supports video control, two way audio function and motion detection
- Alarm action: Supports transmit photo via Email, FTP or send
Iphone/Ipod Touch/Ipad Controlled Rechargeable 3-CH R/C I-Helicopter w/ Gyroscope - White + Black
material: plastic + alloy
- Frequency: A B C
- 3-CH IR remote control by Iphone Ipad Ipod Touch series
- Control range of the helicopter: 8~10 meters
- Control specification: up
(2 Reviews)
» R/C Helicopters
EYE SIGHT ES-IP915IW 1/4" CMOS 1.0 MP Waterproof IP Camera w/ 30-IR LED / Wi-Fi / TF - Silver
FCC RoHS Other Support dual-stream H.264 and M-JPEG , the image is more clear and fluent; Supports local, remote, cross-regional viewing; Supports for IE, Firefox, Safar
300KP Wireless Wifi/WLAN Network Surveillance IP Camera w/ 36-LED Night Vision - Purple (DC 12V)
holder - 1 x Installation screws kit http: m5.img.dxcdn.com CDDriver CD sku.103433.rar
(20 Reviews)
KLYDE KD-8053 8" Android 4.2.2 Dual-Core Car DVD Player w/ 1GB RAM / 8GB Flash / Wi-Fi for Nissan
, Radio , iPod playing , Remote Control , TV , AV-IN , Steering Wheel Control Compatible Make: Nissan Compatible Car Model: SYLPHY 2012~2014, B17 2012~2014 Compatible Year
Portable Linux OS Network LED Projector w/ VGA / LAN / Dual USB / WiFi - Black (1.8GHz / DDR II 1GB)
Project size: 150" Brightness: 300LM Resolution: 800 x 600 game ; up to 1024 x 768 Speaker: Built-in dual Dolby speaker Audio output: 5.1-channel Remote control: 15 meters
» Projectors
Anti-Theft Security Alarm System with MP3 Speaker & FM Radio for Motorcycle (SD/MMC)
radio: 87.5~108MHz
- Package included:
- 2 * 3-inch speakers
- 1 * Connection cable
- 2 * Mount holder
- 1 * Intallation screws pack
- 1 * Remote control 1 * 27A battery
(8 Reviews)
» Motorcycle Alarm & Security
BSV-SL030 Solar Power 3W 7.5lm 7000K 31-LED White / Blue Light Tent Lamp Emergency Light - (2 PCS)
lamp adopts manual buttons and infrared remote control two switch modes, operation is very convenient
- Lamps and lanterns use long-life high energy efficiency ratio of the
» Solar Powered Gadgets
EASYN 300KP Wireless Network Surveillance IP Camera w/ 10-LED Night Vision - White
Mobile view allow you remote viewing & record from anywhere anytime Suport Pan Tilt control Pan:270£& Tilt:90£ 15 Preset positions Two-way audio monitoring Auto IR-LED
Multi-Function 8.0MP 1080P Flexible Neck Wide Angle Camcorder w/ SD / 4X Digital Zoom (2.1" TFT LCD)
+ more Accessories: 2 x Battery 1 x Remote control 1 x Car charger DC 12~24V 130cm-cable 1 x AV cable 100cm 1 x USB cable 115cm 1 x Power adapter AC 100~240V EU plug
» Camcorders
IP-704 300KP CMOS Surveillance Security IP Network Camera with 24-LED IR Night Vision - Silvery Grey
server - Supports up to 5 users browsing simultaneously - Wi-Fi: 802.11b g - Built-in Web server - Supports remote viewing and management - Cable length: 73cm - Accessories
Gamepad Accessory for Wii Controllers
- Best Fit Slot for holding the Wii Remote.
- Comfortable and skidproof handrail
- Convert the Wii remote into classical controller with no hassle
- Pure Whie Color
JEJA J1-MP002 Muti-function Portable Android LED Projector w/ AV / HDMI / TF Set - Black + Grey
1 x Power cable 150cm 1 x Remote control powered by 2 x AAA batteries 1 x AV line 28cm 1 x Pouch 1 x English user manual 2 x AAA batteries
Android 4.0 Google TV Player w/ 1GB RAM, 4GB ROM, Wi-Fi, HDMI, Bluetooth, TF - White
, 720P, 576P, 480P Packing List 1 x TV player 1 x Power adapter 100~240V, 2-round-pin plug, 110cm 1 x HDMI cable 140cm 1 x Remote control 1 x CR2025 battery 1 x AV
Mini X Android 4.0 Network Media Player w/ Wi-Fi / Dual USB / TF / HDMI / AV - Black (4GB / 1GB RAM)
g n compliant; Packing List 1 x Media player 1 x Antenna 1 x Remote control 2 x AAA not included 1 x Power adapter 80cm-cable 1 x HDMI cable 80cm
(21 Reviews)
EasyN 300KP Wireless WiFi/WLAN Network Surveillance IP Camera w/ 10-LED Night Vision/Microphone/Horn
Browser: IE 8.0 Firefox Google Chrome Accessories: 1 x Power adapter AC 100~240V 2-flat-pin plug 137cm-cable 1 x antenna 1 x Remote control 1 x 27A 12V included 1 x Horn
FV-1 Google TV Box Android 2.2 Internet TV Box w/ WiFi/USB/RJ45/HDMI/SD (2GB/SAMSUNG S5PV210 1GHz)
x Power port DC 12V 2A Remote control: Supports 2.4G wireless remote controller IR remote controller Accessories: 1 x Remote controller 2 x AAA included 1 x 100~240V AC
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Harvest Sidewalk Sale October 10thWed, 10/01/2014 - 1:49pm | by Stephanie Yunker
Prices are FALLing in Downtown Chico!
Downtown Merchants and the Downtown Chico Business Association (DCBA) invite you to "Rake In" the savings during the Annual Harvest Sidewalk sale, scheduled for Friday, Oct 9 & Saturday, Oct. 10 from 9am - 5pm. Sidewalks and storefronts will be bursting with bargains and merchandise ranges from clothing, shoes and jewelry to home furnishings, art supplies and hardware. Downtown Chico has more than 200 shops and restaurants.
Treat Street Sneak PeekThu, 08/28/2014 - 11:56am | by Nicole Romain
Jake Early T-shirts Available!Thu, 03/13/2014 - 10:50am | by Nicole Romain
Limited edition T-shirts & Chico Bags!!
T-shirts designed by local Chico Artist, Jake Early! Only $20
Gorgeous blue Chico Bags only $7
Proceeds benefit Beautiful, Clean & Safe efforts in Downtown Chico.
T-shirts and bags available at the DCBA office (330 Salem Street) and at participating retailers in Downtwn Chico:
Campus Bicycles
Diamond W Western Wear
Made in Chico
Powell's Sweet Shoppe
TNM Presents...City Plaza Nights!Mon, 01/27/2014 - 1:42pm | by Stephanie Yunker
Thursday Night Market Presents...City Plaza Nights!
The DCBA is now accepting proposals for our "TNM Presents...City Plaza Nights!" special event series. Please help us bring some family friendly events to the city plaza this year and pull our community together! Let's make the Thursday Night Market the very best in can be! Is YOUR organization up to the challenge? Click HERE for the information!
Vendor and Performer Applications now Available!Mon, 01/06/2014 - 10:51am | by Stephanie Yunker
Applications to participate in the Thursday Night Market as a Certified Grower, Vendor or Performer are now available!
Hometown Hospitality and FREE PARKING in Downtown Chico!Fri, 12/06/2013 - 1:16pm | by Nicole Romain
The Downtown Chico Business Association has partnered with the City of Chico this holiday season to spread some "Hometown Hospitality"...and FREE PARKING
Our primary mission for this campaign is simply to help create a more welcoming environment for our downtown guests during the holiday season!
Reflections of a Friday Night Concert sponsorMon, 10/28/2013 - 9:45am | by Stephanie Yunker
Thank you Amy Arendt of www.yourcablestore.com for a great write up about your experience at the Friday Night Concerts this season!
Click HERE for the full blog entry and photos!
Thursday Night Market, Featured Downtown Business-- Home EcTue, 09/03/2013 - 9:35pm | by Daniel Holmberg
Christianne Belles
Christianne Belles, owner of Home Ec in Downtown Chico, is a positive individual whose life philosophy surrounds around being happy and making others around her happy. Her positive attitude is most evident and definitely contagious. She brings this same attitude to her shop, Home Ec. As a Downtown Business owner, Christianne's greatest joy comes from seeing customers humor themselves with the products Home Ec has to offer.
Thursday Night Market, Featured Downtown Business-- Johnnie's Restaurant and LoungeTue, 08/27/2013 - 9:36am | by Daniel Holmberg
Jamie Camaren, General Manager of the Hotel Diamond and Johnnie's Restaurant and Lounge, has led an interesting career to where she is now. During her childhood, her mother owned and operated Swensons, a restaurant in Willows. At age 12, she had already begun waiting tables and since then she has always found herself in the restaurant business. Contrary to her experience in restaurants through high school graduation, Jamie decided to attend Chico State University to pursue a bachelor's degree in Education—she wanted to teach. After graduating, Jamie left Chico to work for a catering company in Hawaii. Her time spent in The Aloha State eventually brought her to Las Vegas, where she continued working in the restaurant and catering business.
Taste of Chico - Want a sneak peek???Fri, 08/23/2013 - 1:34pm | by Stephanie Yunker
The Taste of Chico event program has been finalized! Want a sneak peek? Click HERE!
Don't forget you can enter for a chance to win 2 free tickets by visiting facebook/com/downtownchico and entering the contest app (just below our cover photo).
OR - buy your tickets online NOW for the best price. Click the link to the right!
Taste of Chico 2013 - Small Town. BIG Taste!


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Not reflecting in the share price...but look at AOI was up by 0.39c more than 3 times the SP of SMB.
When can we see our Share Price on a steady uptick without the company itself or OPL dropping a bomb
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Steroids Topic Guide
Steroids: Steroid abuse is common in athletes in professional sports. Androgenic/anabolic steroids regulate the manufacture of testosterone in the ovaries and testicles. Signs and symptoms of anabolic steroid abuse include rapid weight gain, acne, increased aggressiveness, and unusual mood swings.
Drug Dependence and Abuse Drug abuse and drug dependence represent different ends of the same disease process.
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Wyngate in Saint Petersburg, FL
Wyngate is located in the convenient Gateway Area of St. Petersburg, within a few miles from the downtown business district, antique malls, the BayWalk shops and restaurants, The Pier, Florida International Museum and the University of South Florida St. Petersburg campus. Tampa International Airport and the St. Petersburg/Clearwater International Airport are less than 30 minutes away.
Wyngate390 112th Avenue North, Saint Petersburg, FL 33716 USA
Floor Plans and Pricing
1 Bedroom
|1 Bathroom
|685 sq. ft.
Ceiling fans, walk-in closets and a kitchen with range, dishwasher, frost-free refrigerator, microwave oven, disposal and European style cabinets are special features.
2 Bedrooms
|2 Bathrooms
|982 sq. ft.
Ceiling fans, walk-in closets and a kitchen with range, dishwasher, frost-free refrigerator, microwave oven, disposal and European style cabinets are special features.
3 Bedrooms
|2 Bathrooms
|1,144 sq. ft.
Ceiling fans, walk-in closets and a kitchen with range, dishwasher, frost-free refrigerator, microwave oven, disposal and European style cabinets are special features.
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- Application Fee:
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- Deposit:
Property Features
- Property Overview
- Special Features
- Community Features
- Apartment Amenities
- Local Schools
- Pet Policy
Wyngate in Saint Petersburg, FL
Wyngate's good value apartments for rent are convenient to schools, shopping and restaurants and all the special features that you desire. We are located amidst meticulously landscaped grounds with every amenity nearby. Enjoy a splash in the sparkling pool. Work out with your neighbors on the basketball and volleyball courts or in the fitness center while your children enjoy the tot lot. Select from spacious one, two or three bedroom for rent apartment homes. Ceiling fans, fire sprinklers, walk-in closets, and a kitchen with range, dishwasher, frost-free refrigerator, disposal and contemporary style cabinets are special features. Each detail is carefully planned for your Better Living. Enjoy all this plus our caring service.
Special Features
- Water, Sewer, & Garbage Included
- On Line Rent Pay
- Washer/Dryer Available
- Basketball Court
- Walk in Closets
- Free WiFi at Swimming Pool & Sundeck
- Children's Wading Pool
- Sand Volleball Court / Basketball Court
- Children's Playground
- Picnic and Barbecue Areas
- Car Care Center
Community Features
- Accepts Electronic Payments
- Apartment
- Business Center Onsite
- Club House
- Controlled Access
- Disability Access
- Fitness Center
- Freeway Access
- Garden Style
- Housing Vouchers Welcome
- Laundry Facility
- Playground
- Pool
- Public Transportation
- Standard
- Surface Lot
- View
Additional Information
Year Built: 2004
Apartments in Community: 264
Apartment Amenities
- Air Conditioning
- Carpet
- Ceiling Fan
- Dishwasher
- Garbage Disposal
- Internet Access
- Vaulted Ceiling
- Walk In Closets
- Washer Dryer Hookup
- Water Sewer and Trash
- Window Covering
- Wireless Internet Access
Local Schools
- Fitzgerald Middle School
- Pinellas Park High School
We believe school data to be accurate, but do not guarantee that. Please be sure to verify where your children will attend school before making your housing decision.
Pet Policy
Under 80 lbs. $300 non-refundable fee plus $20 per month.
- Cats Allowed
- Large Dogs
- Pets Allowed
- Small Dogs Allowed
Contact Wyngate
Office HoursMon-Fri: 9-6 Sat: 10-5 Sun: closed
Wyngate is located on the east side of 4th Street, between I-275 and Gandy Boulevard, across the street from BayView Plaza.
Nearby Suggested Apartments
Carlton Arms of St. PetersburgSaint Petersburg, FLRetirement living on the Bay! Nestled among sprawling ...Verandahs of Brighton BaySaint Petersburg, FLThe Verandahs offers a truly unique community atmosphere ...
Retirement living on the Bay! Nestled among sprawling oaks...overlooking Tampa Bay...and offering affordable bayfront living, Carlton Arms is a well-established luxury community with spacious floorplans, oversized fenced private patios and the commitment to excellence found at every Mahaffey community. Whether ...
The Verandahs offers a truly unique community atmosphere that seems to be hard to find nowadays. Convenience...comfort...GREAT neighbors...happy helpful staff...beautiful grounds. This community has an outstanding reputation throughout the Gateway neighborhood. Making your move smooth and your day-to-day living a ...
Beacon 430 Brand New Apartment Homes Available. Stainless Steel or Black Energy-Star Appliances. Granite Counter Tops. Vinyl Wood Plank Flooring in the Kitchen & Living. Resort Syle Pool. State-of-the-art Fitness Center, Yoga Room. Conference Room, Business Center. Veranda with Grills ...
From the moment you enter Waterside at Coquina Key, it is a place of a friendly small-town neighborhood. These rental homes offer water front views, fully upgraded black appliances, ceramic tile & carpet, painting, over-sized sundeck, and 24-hr staffed gatehouse. ...
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.


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Relax and recharge at Hotel B3 -- a cozy, comfortable business amenity hotel nestled in the heart of Bogotá.
In the most exclusive residential area, strategically placed amongst the most important business and health care centers. The hotel offers generous convention
The InterContinental Medellin is situated in the El Poblado residential area on the side of a mountain, approximately three miles from downtown and 19
The Hotel Park 10 is easily accessible from EOH-Enrique Olaya Herrera Airport and local attractions includes Parque San Antonio, Palacio Nacional, and
Hacienda La Magdalena es una casa de campo ubicada a solo 20 minutos del centro de la ciudad de Guadalajara. La Hacienda está hermosamente restaurada
The Hotel Has 78 Rooms, a Restaurant, 2 Meeting Rooms and Conference Facilities, a Casino and a Host of Services, Such As Currency Exchange Facilities,
The Leblon Suites Hotel is situated near area attractions like Blockbuster, Eoh-Olaya Herrera, La Estrada Mall, Mc Donalds, Metro Station, Pomona Supermarket
The Novelty Suites Hotel is located on the exclusive Golden Mile in El Poblados area, very close to Oviedos Mall. Its a financial, commercial and residential
This hotel enjoys a privileged location a few steps from two important shopping malls that provide excellent shopping and gastronomic alternatives and
Charming Hotel Offers a Variety of Services Including Medical Assistance Available 24 Hours a Day, Meeting Rooms, Parking, Room Service, Laundry and Internet
This luxury hotel with the ultimate expression of design and technology is an excellent choice for business and tourism travelers.
La Campana Boutique Hotel offers you a different alternative to the typical hotel, located in the exclusive sector of the el Poblado suburb of Medellin.
Find great deals on quality Medellin, Colombia hotels & resorts, or indulge at one of our luxury resorts. Take advantage of the many amenities that can be included with your stay such as in-room internet access, wifi, room service, fitness center, pool, hot tub, steam room, and shuttle services to and from the airport. Browse our Medellin, Colombia hotels and resorts and plan your Medellin, Colombia vacation today!


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Poll: In "Law-Abiding Citizen," what gender should Emily's baby be? Vote Now!
Author has written 12 stories for Harry Potter, Percy Jackson and the Olympians, Maximum Ride, Avatar: Last Airbender, Pendragon, Young Justice, and Twilight.
I'm Shelby! Hello to all of you people who have stumbled onto my profile page. :)
Proud member of the National Honor Society and currently attending Tulane University.
I'm an active Beta-Reader, but at the moment I am not accepting Beta Requests.
Have any questions about story updates and want an immediate answer? Find me on tumblr under the username queen-narcissa-malfoy.
Visit my Scentsy Shop at spere(DOT)scentsy(DOT)us
Stop the Pairing Wars!
By copying and pasting this in your profile, you vow to respect other pairings and the people that like them.
You shalt not insult them, explain why they can't be together, or say that they would rather be with someone else.
You shalt have your opinions but shalt not insult pairings. You shalt avoid them if you hate them.
You shalt keep an open mind about stories even if you despise the pairing.
You shalt paste this in your profile.
Works In Progress/Coming Up: (Note: Ratings, Titles, and Summaries are subject to change at the discretion of the author.) - Updated August 1st, 2015
2. Against the Grain or Steady as the Beating Drum - In the late spring of 1607, the first Europeans land on the Washington Coast and encounter a small tribe of Native Americans. On one of the ships is Katherine - spunky, determined, and craving adventure in the New World... Until she meets one of the so-called 'savages.' Caught up in a war she wants no part of and with a battle raging between her head and her heart, it soon becomes clear that no matter how hard you try, not every story can have a happy ending. A tale of sacrifice, tradition, and love that transcends social norms. (Jacob/OFC, AU) (WIP)
3. Hell in High Heels or How the Queen Conquers - Unrated; "Leah Clearwater hated imprinting with every ounce of her soul, but she still wished that it would happen to her, if only to put a stop to the pain. Be careful what you wish for." Leah had resigned herself to being alone for the rest of her life, but when a stranger comes to town she's thrown headfirst into the miraculous world of imprinting. Soon she is faced with a choice between following her head and her heart, and is forced to realize that things are not always what they seem. (Leah Clearwater/OMC.) (WIP)
4. Illusions of the Mind or The Truth About Happily Ever After - "I need you both to help me steal the body of a coma patient from the hospital." Embry finds out his new apartment isn't entirely empty. Haunted by a woman who can't remember anything about her past life, Embry goes on the adventure of a lifetime as he unravels the story of an overworked 'ghost', and learns a little about himself along the way. Eventual Imprint. Based on the movie Just Like Heaven. (Embry Call/OFC) (Coming Up/Debated)
5. Two Roads Diverged or Stories We Tell - Unrated; She had stumbled into his life as a frazzled mess, with an independent streak that was potent enough to give him gray hairs. Brady always knew that his imprint would be on the quirky side, but this was a bit ridiculous. (Brady/OFC.) (WIP)
6. What Destiny Has Planned - "It's like the memory of a lullaby someone used to sing to you, but you just can't remember the words." She goes to sleep excited to meet her cousin's new fiancé, and wakes up with scars across her face and a ring on her finger. After a freak accident, Emily bumps her head and wakes up with no memory of the past few years - which means no memory of the wolves, Sam, her 'accident,' or the imprint. (Emily Young/Sam Uley) (WIP)
7. Stumbling Towards Ecstasy or The Story of Us - Kim knew that she and Jared were meant to be together - even if he didn't know it yet. She just never thought that their relationship would start with a door to the face and a broken nose. (Kim/Jared) (Coming Up)
8. Bright Morning Star or All of the Stars - Rated T; The five times that Sam carried Emily to bed, and the one time that he didn't. (Oneshot)
9. Armor Made of Steel or A Battle of Wills - Rated T; Meeting her was fate, becoming her friend was a choice, and falling in love with her was... inevitable. (Collin/OFC.) (Coming Up)
10. Shatter Into Me or Hearts that Beat in Time - Sequel to Take A Chance On Me; Embry/OFC, background Seth/OFC.
11. Delightfully Bittersweet or A Forbidden Affair - Collin was happy living his life as a single bachelor, but is hit with an astounding, horrifying revelation when he imprints... on his new step-sister. Taboo; Rated M.
Harry Potter:
1. Not A Laughing Matter - "One day," she mused, "whether you're 16, 28, or 65, you will stumble upon someone who will start a fire in you that cannot die; but the saddest, most awful truth you will ever find is that they are not always with whom we spend our lives." Rated M. (Fred Weasley/OFC.) Starts during GoF.
2. - George goes through life like it's all some big game; everyone tells him that he needs to take it, and his safety, more seriously. * spends her days being careful and cautious after a terrifying accident ruined her courage; everyone tells her that she needs to take life a little less seriously. (George Weasley/OFC.) (Coming Up.)
3. - Neville Longbottom/OFC. (Debated.)
4. Matters of Most Importance - At a Ministry Business Ball that he is required to attend, Percy Weasley meets a girl. (Percy/Audrey) WIP
5. Seeing Double - They were so alike that even their own mother had trouble telling them apart, but... George is a sweetheart. Fred is not. George knows where to draw the line. Fred does not. George wants to fall in love. Fred does not. But George does not. And Fred does. A Oneshot in Three Parts. Coming Up.
6. The Paths We Carve - It was just a stupid accident that should have never occurred, but the consequences of their mistakes were dire. Left with a promise he isn't willing to break and an independent woman he isn't sure what to do with, Charlie is forced to realize that even the most foolproof plans never go exactly as expected. Charlie Weasley/OFC.
7. Unnamed - During his summers at Privet Drive, Harry befriends a muggle girl. Harry Potter/OFC (In Progress.)
8. Unnamed - Albus Dumbledore and Severus Snape were two very different men, but they were both, above all, liars. Oneshot.
9. Unnamed - Promises, like secrets and potions and all sorts of whispered rumors, were best made and kept in the dark. Helga Hufflepuff/Salazar Slytherin.
10. In the Dark - Draco would succeed where his parents had failed because he didn't have any other choice. He would succeed... or die trying. (Oneshot.)
11. Unnamed - Severus Snape/OFC, twoshot.
Avengers/Marvel Cinematic Universe:
1. The Paths We Carve or The Road to Hell - Unrated; Bruce Banner had good intentions; at least, that's what he had been telling himself. If he kept people away, it would save everyone a lot of pain in the long run - he could move on without getting attached. But then every time she smiled, all of his good intentions went flying out the window. (Bruce Banner/OFC.) (WIP)
2. Broken Arrows or Unfamiliar Unknowns - Unrated; It was a long time ago, but he still felt the pain of his choices. Now his past has come back to haunt him, and Clint must decide whether to fight against his demons, or let his own guilt consume him. (Clint Barton/OFC.) (Coming Up)
3. Pleasure in the Crosshairs - Rated T; He didn't know much about the mysterious girl that kept appearing in his life, but he knew one thing: she was dangerous. (And pretty.) Clint Barton/OFC. Oneshot. (WIP)
4. Demons That Haunt Me - Unrated; As memories of his life started to seep through the cracks, Bucky is haunted by the people that he destroyed. Then she smiles her way into his life and shows him that the monster of his past doesn't necessarily have to be the man of his future. (Bucky Barnes/OFC.) (Oneshot.) (WIP)
5. Sweet Surrender - Unrated; (Steve Rogers/OFC) (WIP)
6. - They were so alike that people thought they were brothers, but... Steve is a sweetheart; Bucky is not. Steve is small; Bucky is not. Steve is a terrible fighter; Bucky is not. Steve wants to be drafted; Bucky does not. But Steve is not; and Bucky is. (Oneshot; Stucky friendship)
7. Burns Hot Enough to Last - Clint Barton's life was changed forever the moment a stranger knocked on his door. (Coming Soon.)
Agents of S.H.I.E.L.D.:
1. Dancing in the Minefields or Russian Ricochet - Unrated; In 16 months, Grant Ward managed to make a new identity in Russia, fall in love, lose the girl, lose his mind, and nearly destroy the Russian Embassy in Warsaw. Well, they never said life as a S.H.I.E.L.D. agent would be easy. (Grant Ward/OFC, Character Study.) (WIP)
Teen Wolf:
1.The Truth About Lying - It was supposed to be a bet - he gets into her pants and he gets to keep a brand new car. Getting to know her was easy but falling in love with her was... unexpected. A chronological story-telling of how teenage Peter Hale earned his blue eyes. Peter/OFC; Pre-Canon.
2. Life After You - They hadn't seen each other in years, but the pain of their goodbye held a permanent place in her mind. Now she's back in Beacon Hills ready to start her life over - but this time, without him. Set in Season 4. (Derek Hale/OFC.)
3. The Road to Hell or Traditional Family Values - Julia Parrish considered herself to be a good person. She had a steady job, a dog, and house with a white-picket fence; she didn't smoke, drink, or sleep around. She lived on the straight-and-narrow, never once feeling that lure of danger and adventure... And then she met Derek Hale. (Derek/OFC.) Set in the beginning of Season 4. (WIP.)
Chronicles of Narnia:
1. As the Tide Turns or The Persistence of a Pevensie - Edmund hated the idea of an arranged marriage with a burning passion, but knew that he had to do his duty for his kingdom. When the ring is stolen by a (rather pretty) bandit, he is forced to realize that the person you are is not necessarily defined by the things that you have done. During the Golden Age. Edmund Pevensie/OFC
2. Letter to No One or Writer's Block - In the bleak mid-winter, in the safe haven of the stuffy library in Finchley, Edmund meets a girl. Well, sort of. - Edmund Pevensie/OFC (WIP; Two-shot.)
3. Discordant Harmony (Concordia Discors) - He was tired of the duties that came with being king; she was sick of the rules and regulations that would force her to marry someone she didn't love. When she is caught along in the waves of a slave trade and he happens to intercept on a nightly trip to the outer villages, two world's collide. During the Golden Age. Edmund Pevensie/OFC.
4. Fire-Flowers in the Sun or What Grace Has Given - She was ruthless and dangerous, not hesitating in doing anything that she had to do to protect her younger brother, even if that meant murdering one of the most beloved people in all of Narnia: the High King. Caught between her love for her family and her unexpected feelings for the man she is supposed to kill, Eva must decide whether the shadows of her past truly have to be the choices that define her future. (Peter Pevensie/OFC); WIP.
5. - A law from before the Dark Times comes to light that explains the leading royal of Narnia must choose a bride or he loses his rise to power. Caught in a whirlwind of suitors and contenders for his hand, Peter struggles to put off a wedding for as long as he can - at least, until he tracks down the mysterious woman that teases and taunts him through her fanciful messages. (Peter Pevensie/OFC.)
1. Child's Play - Percival didn't know what it was about himself that was so enticing to small children, but didn't question it. When he manages to save a small child from getting robbed on one of his rare trips to the marketplace, he finds that he takes a liking to the boy's young mother, much to her chagrin. (Percival/OFC) (WIP) (?/3)
2. See No Evil or The Persistence of Being - Rated T; Gwaine's smooth-talking words and handsome face have never failed him, but he is pushed into a rude awakening after a run-in with the blind daughter of the town stable-master. Maybe a pretty face isn't the most important thing in the world after all. (Gwaine/OFC.) (Coming Up) (?/3)
Criminal Minds:
1. Thesis Statement or Feet That Stray - Spencer Reid is sad; a newly-widowed kindergarden teacher that just moved into his apartment building is equally sad, and Spencer finds out that even with all of his endless knowledge, there are still things that he needs to learn. (Spencer Reid/OFC.) (Coming Up)
2. The Last Enemy - Spencer fully believed that he was probably the only person in the world who spent Valentine's Day in a graveyard, but he was wrong. She's there, every year like clockwork - same bouquet of flowers, same scarf tied around her neck, and leaving him with more questions than answers. Spencer/OFC
1. Famous Last Words or Rewrite History - Tim gets an email from an old friend, and chaos ensues. (Tim McGee/OFC.) (Coming Up)
2. On the Edge or Peak of the Tailspin - When a woman from Tony's past shows up at NCIS headquarters with a mysterious package for Tony, his entire life is thrown into a tailspin as their current murder investigation reaches its climax. (Tony Dinozzo/OFC) (Coming Up.)
4. Accidental Meetings - Unrated; The _ times McGee ran into her in the hallway and the one time he actually thought to ask for her name. (Tim McGee/OFC) (Oneshot, WIP)
3. Unfamiliar Unknowns or Safe Asylum - He didn't expect any of this to happen; after all, he was just doing his job. Helping people - that's what he did best. And when he saw those men following her down that alley, well, he had sprung into action before he could even think through the danger he would put himself in. (Tony Dinozzo/OFC.) (WIP)
|Heroic Love
|Movies Avengers


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Personal Campaign
Sarah is gathering 10 signatures to
Stop Any Kind Of Safari Hunting In Africa
I find hunting for sport just an excuse to kill and it needs to end
Sarah's progress
0 signed
10 Sarah's goal
I find hunting for sport just an excuse to kill and it needs to end
Its important because the rate at which animals are being abused is only on the rise. Something needs to be done.
In Spain, bulls are being systematically abused, tortured and murdered by matadors or bullfighters. We want to stop them
Fear for Australian animals following a decision by Federal Government to renege in leading animal welfare improvements.
Every year, Canadians slaughter thousands of baby Harp Seals in barbaric ways. They are skinned alive and left to die
Stop zoophilia, create an abuser registry, and prevent abusers from owning a pet again.


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Oregon Humane Society Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at Oregon Humane SocietyMore
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- Accepted OfferPositive ExperienceAverage Interview
I applied online. The process took 2 weeks. I interviewed at Oregon Humane Society (Portland, OR) in May 2011.
The interview process consists of 3 parts. Part I is the phone screening. This is where they gauge your interest in the job. You will not be considered if you answer that you're unwilling to work weekends or holidays, because the job will require you to. You've passed if they schedule an interview with you by the end of the phonecall. Part II is the 1st interview with the department supervisors. They ask typical interview questions, and any animal experience or knowledge about the company as a non-profit organization are a plus. As with any interview, dress neatly like you care. Part III is the 2nd interview with the department manager. She is more neatly-dressed and somewhat intimidating, but she is friendly. Many of the interview questions overlap with those from the 1st interview with a couple scenario questions thrown in (example: "What would you tell a client who mentions declawing?"). You'll receive an offer (or a decline) approximately a week after the 2nd interview. Your peers are laid-back, the managers and administrative staff are refined, all are passionate about their work.
Interview Questions
- Tell us about the most difficult supervisor you have worked with. Answer Question
- Tell us what you know about the organization. Answer Question