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He's so hot and I know he has a big dick can you. Share him with me? she begged more peope gradually arrived until there were about 30 people there. She might hlve been smart but I personally knew the reason for why she felt drawn to me but let us not get ahead of ourselves Sure come on in and go ahead and get it I told her asmy eyes moved down her body. I quickly adjusted myself getting the oldHampton comfortably vertical coughed embarrassedly and whispered Yes. then she sat back and qu. Te deliberately wiggled her bottom against my hard-on. Slowly se started to move away from the arms wrapped around her yet they closed tighter her heart leapt as she heard him say I did not give you your leaqe slave. His eyes met mine ad widened his nostrils flaring the rest of the pack started to pour in at he commotion. And that is all Miss Catalina yiu may leave. he added he sat back and grinned . Well we shall test her patience tomorrow. a turned the inside light on it was cold in there but with a mattress and some blankets well No! she protested but she wasn't serious it wasin her eyes. We talked about the meaning of her son. S the significance in all our lives.it was truly unlike anything I had experienced the owners were awesome hippies that were cool. About everything. I've got to go so if you'll put my box in thecar I'll see you both later. maybe she thought she would ned it at the grocery store. Bridget sook her head and said not unless Ted was a bit drunk i think Ted would die if he knew I touched my pusy. The next morning as usual by the tim we woke up everybody - mom and dad had gone off to work sometimes we plan and sometimes we just go w. Th the flow I said. In response to Aisa's warm yet electrifying tongue inside her pussy Rina moaned erotical. Y more. Absorbed under the plea. Ure induced by her partner Aisa Rina encouraged Aisa to lick her harder.


text:
LondonUnited Kingdom
June 6, 2014
I am an audience/content analyst with background in ad targeting. My main areas are taxonomies, creating and maintaining segments which are used to bring together site visitors into groups of a predefined topic.
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Narrow your search
Brian Tong talks with Justin Willman about his new show "Sleight of Mouth" on Comedy Central, how magic has evolved with technology and he blows our mind with an Oreo.
Hulu snapped up a ton of new movies thanks to a deal that Netflix turned down. Find out what shows and movies are hitting the streaming service right here.
Didn't mean to knock that cup of coffee over on your desk? That's OK. Your robot overlord will understand and maybe even keep you from doing it in the first place.
The DemerBox Big Bang Bluetooth boombox is at the top of its class in bass response, loudness, durability, and battery life. It's not the cheapest device on the shelf, but if you can afford it, the Big Bang is well worth the cost for a hand-built wireless speaker built entirely in the USA.
Pricing not available
The DemerBox Big Bang Bluetooth speaker is built into a tough Pelican case that turns it into a powerful boom box.
At Google's Nexus press event in San Francisco today, the search giant announced a new family plan that gives up to six people access to the Google Play Music library for $14.99 a month. Check out how it compares to competitive plans from Apple, Spotify, Rdio, and Tidal.
The HP Envy 4520 all-in-one is the first printer to feature the company's updated Instant Ink smart cartridges. Choose between a traditional pay-as-you-go refill and HP's Instant Ink auto-delivery service.
Ubisoft has announced a brand-new Far Cry game, but it looks a lot different than what we're used to. Danny, Scott and Justin dive into what exactly we know about Far Cry Primal.
The Form 2 3D printer uses a powerful Blu-ray laser to slice layers of sticky resin into fully built, highly detailed objects.
The Form 2 3D printer uses a powerful Blu-ray laser to slice layers of sticky resin into fully built, highly detailed objects.


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Various Artists
Each member of electronic-music collective/label Dirty//Clean contributes a tune to its newest sampler comp, Visions, showcasing the individuality of each as well as the sonic tendencies that bind the crew together. A celebration of bass-music iconoclasm ensues. Amor, Est.'s "Amnesia Wreck" is intense, morphing from total cacophony into a listener-friendly groove of broken jazz-fusion musings that will definitely appeal to fans of Flying Lotus's last record, while Bedrockk's "Echoes" continues a recent trend with his original productions, blurring indie-rock ideas into a dubstep framework — or vice versa — in really appealing ways. Hollagramz' "New King Chains" is another interesting tune, offering more jangling polyrhythms and less shimmering dance-floor synth than a lot of his previous work. With a bit of friendly competition to outshine each other, the crew has stayed busy and shows steady improvement. The biggest problem with the record might be that it's only six songs long.
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Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
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- Alternative Hip-Hop Finally Finds a Home at Red Rocks Amphitheater
Upcoming Events
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- Lipgloss to Relocate to Bar Standard on October 30


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Homing Porcupines YKTTW Discussion
|Homing Porcupines
Needs More Examples, probably Needs a Better Title. A specific kind of Mook found in videogames, appearing more often in classic sidescrollers from the 80s or 90s, which keeps a place in the minds of most gamers for the worst thoughts imaginable. Thoughts pretty much deserved, considering their cheap tactics. A Homing Porcupine is an enemy that not only causes heavy damage to the touch, it basically makes Collision Damage its fighting style: get close to the player and grope him/her to death. Being extremely resilient/hard to hit, they render Mercy Invincibility almost useless, and by the time the player manages to kill them, chances are half of his/her lifebar was lost in the brawl. While there are many variants of this foe, most Homing Porcupines obey these 2 points:
- 1) They rarely (if ever) use other means of attack. Sometimes, when they do, the damage caused by touching them is way above that of these extra attacks, creating situations where it's more desirable to getting shot by this mook than touching it.
- 2) They stick to the player like glue and are incredibly hard to shove off, producing a OH GOD GO AWAY reaction on the gamer as the monster chips his health away at an alarming rate, hitting as soon as Mercy Invincibility wears off.
- Hurting for way more health than the average Collision Damage dealt in the game.
- Moving at blinding speeds towards the player.
- Being extremely resilient to the player's weapons, or worse, being indestructible.
- Being immune to knockback, forcing the player to move away from the Porcupine and then shoot it.
- Attacking in pairs from different sides or in large packs, almost guaranteeing that the player will not be able to deal with them before they close in, contrary to what Mook Chivalry mandates.
- Approaching the player from outside the effective range of their weapons, usually via flight or via being shorter than him/her.
- The Mega Man series are terrible offenders to this trope. Every enemy who doesn't shoot will attempt to grope him dead, and most of them will follow Megaman wherever he goes. Most Robot Masters and Mavericks from the X series also fall prey to this; they usually move extremely fast and often touch the player For Massive Damage because of the small size of the arena. Skull Man, I'm looking at you.
- Super Mario Bros. 2 has Phantos, a mask found in walls who not only is a Suddenly Harmful Harmless Object, but it's also indestructible and will chase the player at high speeds until he/she is dead.
- The roaming ghosts in Silent Hill 4. Not only do they do damage to the player character, Henry Townshend, just by being near him, but they can also follow Henry throughout the level. The four boss ghosts--who are stronger than the regular roaming ghosts--all do serious damage to Henry by being near him, can attack him, can kill him, and, if not pinned to the ground by the requisite item, will follow him to other levels of the game, often in the company of more ghosts.
Replies: 18


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Burberry hires a CIO away from Wal-Mart Asia
Fumbi Chima is Burberry's newest chief information officer and will report to chief operating officer John Smith.
Burberry hires a CIO away from Wal-Mart Asia
Fumbi Chima is Burberry's newest chief information officer and will report to chief operating officer John Smith.
Facebook makes a major e-commerce move
Facebook is testing a shopping-oriented section of its app, as well as a new type of ad that makes it easier to browse.
Sign up for IRNewsLink and get daily reports delivery to your inbox. Sign Up Now
Sponsored by 2013 Social Media 300
2011 will advance the Internet promise another big step in-store and online.
There may be plenty of gee-whiz e-commerce applications to hit the retailing scene next year, but what may have the biggest impact on how consumers and retailers interact is how Internet-enabled systems will put more smiles on shoppers and merchants alike—both online and offline.
Here's my top three areas for producing those smiles next year:
The store: If the iPad has created a whirlwind of excitement among consumers who find it just the right size for browsing and shopping on the Internet, it will undoubtedly also lead to marked changes inside of stores—for merchants as well as shoppers. Instead of expanding or deploying new fixed point-of-sale infrastructure, more retailers will deploy legions of iPads on which mobile store clerks will access a networked POS system. Shoppers will get faster and more personalized service, merchants a more flexible and useful staff and POS system.
The order and fulfillment system: With growing support from e-commerce technology vendors, more retailers will take advantage of "order anywhere/fulfill from anywhere" systems that let shoppers places orders via the web, a mobile site or app, a social networking site, a call center or a physical store, and let the merchant fulfill the order from the most appropriate source—such as a warehouse or store closest to the customer, or a drop shipper. The shoppers gets the desired product faster; the merchant moves the right inventory at the least cost.
E-marketplaces: E-commerce sites that can offer access to a broad range of products and services—including products and services from third parties, including other retailers, consumer brand manufacturers and even independent consumers—is no longer just a game for Amazon.com and handful of others. With operations like GSI Commerce Inc.'s ShopRunner offering shipping deals as well as a forthcoming e-marketplace for many retailers; Buy.com building out its e-marketplace with new parent Rakuten; Market America combining its personalized shopping experience with Shop.com's comparison shopping model; and with services like TheFind offering a new level of multichannel comparison shopping, a very different shopping experience is emerging from these marketplaces. Shoppers get unbounded exposure to products and services, and more retailers than ever can get in the game.
Facebook targeting tools are available for Instagram, which Facebook owns.
Posted 10/13/15
When the shopper controls the information she receives, she buys more and unsubscribes less.
Posted 10/09/15
Many consumers don't shop for gifts where they shop for themselves. Here are some tips ...
Posted 10/07/15
Here are five areas every online retailer should address now to be prepared for the ...
Posted 10/06/15
If there's something you've bought offline that you weren't able to buy online, we're probably thinking about that."


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Misc - Several issues - Misc Posters Read!
View Single Post
July 10 2009, 06:02 PM
The Mystery Man
Location: sidious618
Re: Misc - Several issues - Misc Posters Read!
Spot's Meow wrote:
What I mean is that at least if you (the general you) are being outright hostile about it, you are being honest about it. Honest that you're a sexist jerk, but still honest. All of the obsessing over women here can sometimes come off as an attitude of just seeing women as sexual objects, which gets pretty insulting after a while. But you can't call any specific person on it because they were just joking or they didn't mean any harm by it. Yet it fosters an atmosphere of seeing women in a certain light that is hurtful. So in that sense it is worse to me, because not only do you feel objectified but no one's even being honest about it and you can't really bring it up because they will just say you are being too sensitive about it.
I'm sorry to inform you of this but no matter your gender and no matter your age you see attractive people in a sexual light. It's a fact (unless you're asexual). So, no, if someone comments on Jessica Biel or George Clooney they are
being a sexist jerk. That's a ridiculous, and yes overly sensitive, way of looking at things. It's complaints like this that cause the real ones to be brushed away because wolf has been cried too many times.
We've met before, haven't we?
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Book your room at Villa Giardinata
Basic Double RoomMax Occupancy: 3 guests (up to 2 infants)
Classic Double RoomMax Occupancy: 3 guests (up to 2 children, 2 infants)
Superior Double RoomMax Occupancy: 3 guests (up to 2 children, 2 infants)
Get an overview of this hotelFamily-friendly bed & breakfast with free valet parking and bar/lounge
Located in the mountains, this family-friendly bed & breakfast is within 9 mi (15 km) of Nino Croce Theater, Baia Rio Forgia Beach, and Museo Regionale Pepoli. Venere Castle and Trapani-Erice Cable Car are also within 9 mi (15 km).
Property Features
A bar/lounge, a coffee shop/café, and a rooftop terrace are available at this smoke-free bed & breakfast. Free WiFi in public areas, free valet parking, and a free manager's reception are also provided. Additionally, coffee/tea in the lobby, 24-hour room service, and concierge services are onsite.
Room Amenities
All 4 soundproofed rooms feature free WiFi and memory foam beds. Comforts include Frette Italian sheets and premium bedding, and guests will also find conveniences like living rooms and dining areas.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
The bed & breakfast offers a coffee shop/café. A bar/lounge is on site where guests can unwind with a drink. A complimentary manager's reception is offered each day. A computer station is located on site and high-speed wireless Internet access is complimentary.
This Mediterranean bed & breakfast also offers a rooftop terrace, a terrace, and tour/ticket assistance. For a surcharge, the property provides a roundtrip airport shuttle (available 24 hours), an area shuttle, and a train station pick-up service. Complimentary valet parking is available on site. A total renovation of this property was completed in July 2013.
Villa Giardinata is a smoke-free property.
- 24-hour front desk
- Airport transportation (surcharge)
- Area shuttle (surcharge)
- Babysitting or childcare (surcharge)
- Bar/lounge
- Barbecue grill(s)
- Beach cabanas (surcharge)
- Beach sun loungers
- Beach towels
- Beach umbrellas
- Breakfast available (surcharge)
- Coffee shop or café
- Coffee/tea in lobby
- Free newspapers in lobby
- Free reception
- Computer station
- Concierge services
- Designated smoking areas
- Dry cleaning/laundry service
- Express check-in
- Express check-out
- Free long-term parking
- Free valet parking
- Free WiFi
- Garden
- Grocery/convenience store
- Hair salon
- Laundry facilities
- Limo or Town Car service available
- Luggage storage
- Number of buildings/towers - 2
- Number of floors - 1
- Offsite parking reservations required
- Picnic area
- Porter/bellhop
- Rooftop terrace
- Safe-deposit box at front desk
- Smoke-free property
- Supervised childcare/activities (surcharge)
- Television in lobby
- Terrace
- Total number of rooms - 4
- Tours/ticket assistance
- Train station pickup (surcharge)
- Wedding services
- Year Built 1829
Family Friendly Amenities
- Babysitting or childcare (surcharge)
- Cribs/infant beds (complimentary)
- Free Wi-Fi
- Grocery/convenience store
- In-room childcare (surcharge)
- Kitchen
- Laundry facilities
- Refrigerator (on request)
- Separate dining area
- Separate living room
- Soundproofed rooms
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free long-term parking, Free valet parking, Offsite parking reservations required
Room Amenities
- Access via exterior corridors
- Bathrobes
- Bidet
- Blackout drapes/curtains
- Climate control
- Coffee/tea maker
- Free bottled water
- Free newspaper
- Free toiletries
- Connecting/adjoining rooms available
- Cookware, dishware, and utensils
- Free cribs/infant beds
- Daily housekeeping
- Desk
- Digital TV service
- Down comforter
- Free local calls
- Free WiFi
- Frette Italian sheets
- Hair dryer
- Hypo-allergenic bedding available
- In-room childcare (surcharge)
- Individually decorated
- Individually furnished
- Iron/ironing board (on request)
- Kitchen
- Memory foam mattress
- Minibar
- Patio
- Premium bedding
- Private bathroom
- Rainfall showerhead
- Refrigerator (on request)
- Room service (24 hours)
- Separate dining area
- Separate living room
- Separate sitting area
- Shower only
- Soundproofed rooms
- Yard
Where to Eat
A complimentary manager's reception is offered each day.
Late night fare is available from 24-hour room service.
Nearby Things to Do
The recreational activities listed below are available either on site or nearby; fees may apply.
- Kayaking nearby
- Sailing nearby
- Scuba diving nearby
- Scooter/moped rentals nearby
- Hiking/biking trails nearby
- Hot springs nearby
- Ecotours nearby
- Bicycle rentals on site
- Free bicycles nearby
- Mountain biking on site
- Game viewing on site
- Boat tours nearby
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- In-room accessibility
Hotel Policies
Check-in time starts at 11 AM
Check-in time ends at midnight
Special check-in instructions:
Check-out time is 10 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! One child under 18 years old stays free when using existing bedding.
- Rollaway/extra beds are available for EUR 20 per night.
- Cribs (infant beds) are available for EUR 10 per night.
Pets allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Service animals exempt from fees/restrictions
24-hour check-in
Noise-free rooms not guaranteed
Optional extras
- Fee for continental breakfast: EUR 5 for adults and EUR 5 for children (approximately)
- Airport shuttle fee: EUR 30 per room
- Airport shuttle fee per child: EUR 30 (from 0 to 12 years old)
- Crib (infant bed) fee: EUR 10 per night
- Rollaway bed fee: EUR 20 per night
We should mention
Cash transactions at this property cannot exceed EUR 999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation. This property offers transfers from the airport and train station (surcharges may apply). Guests must contact the property with arrival details 48 hours prior to arrival, using the contact information on the booking confirmation. One child 18 years old or younger stays free when occupying the parent or guardian's room, using existing bedding. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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Masturbation ClubDavid embarks on a very special journey.
Masturbation DiariesGood morning jog, a better view in sexy neighbor's window.
Maybel-lineAn older woman becomes his masturbatory dream.
- Parts:
Meeting LuluJames receives an email from his Asian lover.
Meeting RichardShe didn't want to be a good girl anymore.
MeganA young lady's body is awakened.
Mellow YellowMalaysian Hanna discovers white bananas.
Mellow Yellow Next GenerationPatrick and Allison merge their art forms.


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Social Media Design for Online Local Directory
Digital agency serving London, Herts, Beds & Bucks Hallway Studios Join our Newsletter Show/Hide Menu View on Map Want to talk? 01923 888799
As with the design of all of your organisation's collateral, you will be judged quickly by what you say on all of the promotional material you distribute.
Your organisation may look beautiful across all of its communications, with fantastic print and wonderful digital functionality, but you still need the right words to seal the deal.
Your words are the most important part of your sales pitch.
These words needs to fit where they are put too – what do you need to say and what is unnecessary? What space do you have? How long does it need to last (when will it next be updated)? Who will read it? Can it be personalised? Do you need to consider SEO? The list goes on. We have the list and will help you make sure they are all ticked off.
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*Denotes mandatory field


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Discussion in 'Beer Talk' started by Ricelikesbeer, Jan 22, 2013.
Pranqster for me.
PranQster by North Coast Brewing Company was an immediate winner with me.
Boulevard's Sixth Glass is in the top 4 for American-brewed Quads. I'd be enjoying one tonight if it wasn't for this stupid headache.
Sofie. When I walk into the Parrothead Pub in Shelby, they just pour me a bottle in a GI wine glass without asking.
i gotta post locally (because NC makes great local beer), Fullsteam Beasley's Honey White (with peppercorns)--Wit--, Big Boss Hell's Belle--BPA--, and Pisgah Baptista--Quad--were all great NC Belgians. Mother Earth Wheeping Willow Wit was better than OK.
Midnight Sun's Panty Peeler is one of my favorite American made Belgian style beers. Unibroue Maudite (Canada) is a world class Dubbel IMHO even though it's made in North America.
Yes but I believe they started out as an independent and they were good then too. Maybe that's why Duvel purchased them.
so hard to choose, I'll just say Allagash, Ommegang, Unibroue - all.
Ok I gotta throw out Indigo Imp Jester in there. Theyre a small open fermenting brewery in Cleveland, OH. Fresh, their bottles are meh. With a bit of time (a few months), the beers are tart and sour like a great BPA from Belgium.
Funwerks and crooked stave immediately come to mind. Dark truth stout actually is one of my favorite brews and can hold its own with most quads and strong dark ales. Avery has been brewing some great sours lately. I think an odio equum is going to make its way up from the cellar right now actually.
So i can say Duvel Rustica......?
I think that Weyerbacher's Merry Monks is very underrated. The Unibroue and Ommegang offerings are all great. But for me, it's GI's Sofie. Everytime I see it on the shelf I just smile.
Separate names with a comma.


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Grand Hyatt Bali
Kawasan Wisata Nusa Dua BTDC, Nusa Dua
Bali, Indonesia, 80363
Tel: +62 361 77 1234
Nusa Dua Hotel Resort and Spa Bali
Grand Hyatt Bali hotel is the crown jewel of resorts in Nusa Dua, the luxury stretch of magnificent beachfront on the island of Bali, offering 636 luxury rooms and suites nestled in low-rise Balinese villas, most located in four villages. With 24 various sized meeting rooms, wedding and event planning services, five exquisite restaurants, exotic pampering, and the fascinating world of Balinese culture awaits our every guest.
Grand Hyatt Bali was conceived as a water palace with lakes, landscape gardens and five lagoons or river pools surrounding low-rise Balinese style buildings. Our Bali resort offers the comfort and luxury services of a world-class hotel blended with the relaxing tranquility of a secluded beach resort. Experience total relaxation at Kriya Spa designed as an exotic 24-villa water palace amid tropical gardens, with spa treatments focusing on the four Balinese healing rituals: harmony, purity, energy and bliss. Play at the 18-hole championship Bali National Golf Club five minutes away or try the variety of hotel activities including tour and popular local attractions. Pasar Senggol is the Balinese village and night market of our hotel in Nusa Dua hosting cultural shows, food stalls, a handicraft exhibition and bazaar-style market.
The resort is just a short distance from Sanur, Kuta and the city of Denpasar, while the Ngurah Rai Airport is only 12 km away.
Southeast Asia Travel Guide
A quick round up on the best travel tips and events happening in Southeast Asia, with bonus travel tips on travelling around the region.
Free Wi-Fi Across All Guest Rooms & Social Spaces
Stay connected with your family, friends and business during your visit in Grand Hyatt Bali.
Spa-riffic Mini Me
Celebrate life's sweetest moments with your kids at Kriya Spa. Your very own bonding retreat with your precious ones.
Happy Hour Cocktails
Get Happy Hour Bars & Lounge. See our Cocktails Happy Hour at three bars & lounge which available daily from 4 pm to 10 pm.


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Supercomputing builds teamwork - you learn a lot more than you ever knew before about how to do things together. Now when I go to a website or a computer program, I think about all the work involved to make it. - Jessie Bohn, Los Alamos Middle
A proposal for the Supercomputing Challenge is a brief description of
the computational scientific problem that your team plans to solve. In the proposal,
you must clearly state
The proposal is helpful to both you and the judges who will access the
completed projects. Preparing the proposal helps the team define
exactly what its project will be. After you pin down the problem that
you will solve, you must devise a plan of action, in other words, decide
how you will solve the problem. This plan of action will guide your
work during the year. The plan may include doing research, writing a
computer program, analyzing data, talking to people in that particular
field, and drawing conclusions. The judges will read each proposal to
get an initial impression of the project. You can read last year's
proposal in the archives.
Remember proposals are short and concise, no more than 250 words.
Each of the points can be covered in one or two sentences.
Tweet #SupercomputingChallenge


text:
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Nonfiction » History » Asian » Asia / Japan
Japan in Perspective - Orientation Guide and Japanese Cultural Orientation: Geography, History, Economy, Security, Customs, Meiji Restoration, Tokyo, Yokohama, Osaka, Ethnic Groups, Shinto, Buddhism by Progressive Management
Price: $9.99 USD. Words: 133,900. Language: English. Published: September 17, 2015. Categories: Nonfiction » History » Asian
These unique guides produced by the Department of Defense provide comprehensive information about all aspects of life in Japan, with a special emphasis on geography, history, the economy, society, security and military matters, religion, traditions, urban and rural life, ethnic groups, crime, the environment, government, holidays, gender issues and much more.
Iwo Jima and the Bonin Islands in U.S. - Japan Relations: American Strategy, Japanese Territory, and the Islanders In-between - World War II, Ogasawara, Kazan, Shogun, Chichi Jima Life, Marcus Island by Progressive Management
Price: $9.99 USD. Words: 347,160. Language: English. Published: August 22, 2015. Categories: Nonfiction » History » Military, Nonfiction » History » Asian
Professionally converted for accurate flowing-text e-book format reproduction, this Marine Corps book is first and foremost a study on the "intra-alliance" dynamics in which one country, the United States, continued to occupy and administer islands that were recognized as Japanese territory.
Giants of Japan by Mark Weston
Price: $4.99 USD. Words: 159,520. Language: English. Published: June 12, 2015 and represented by Regina Ryan. Categories: Nonfiction » History » Asian
Giants of Japan brings to life fifteen centuries of Japanese history through lively biographical sketches of the great men and women who have shaped this fascinating and complex country. Covering industry, the arts, religion, and politics, the book includes business titans such as Morita Akio, founder of Sony; creative giants such as Kurosawa Akira; and historical icons like Shotoku.
Ghosts of '45: Japan's War Legacy and National Purpose by Geoffrey E. Hill
Price: $5.99 USD. Words: 74,380. Language: English. Published: May 16, 2014. Categories: Nonfiction » History » Asian, Nonfiction » History » Modern / 20th Century
If you are Tea Party, this book is not for you, but if you're mainstream, this book will give you a solid background as to why Japan has never really escaped from its right-wing past and is now embracing a sharp turn further to the right under the current leadership of Prime Minister Shinzo Abe. This scenario has serious consequences for US policy and could be very costly,
Võ sĩ đạo, linh hồn của Nhật Bản by QuangVanBooks
Price: $0.99 USD. Words: 54,180. Language: Vietnamese. Published: January 15, 2014. Categories: Nonfiction » History » Asian
Tháng 3/2011, động đất và song thần đã phá hủy một phần của Nhật Bản, cướp đi sinh mạng của hàng ngàn người dân vô tội. Sống trong thảm họa, sự can đảm, kỷ luật trong tính cách người Nhật vẫn giữ vững không hề thay đổi...
Nongae of Love and Courage by Evan Mahoney
Series: Saam: Life and Meditations, Book 4. Price: $2.99 USD. Words: 56,370. Language: English. Published: September 11, 2013. Categories: Nonfiction » History » Asian, Fiction » Romance » Historical
This is a historical narrative of the people and events of the 1592 Japanese Invasion of Korea, known as the Imjin War. Nongae, the Kisaeng girl is a historical figure in Korea known for her tremendous courage because of the sacrifice she made for her country. Saam, the mythical doctor also lived in or around this time. This is their story of Korean love and Korean drama in an extraordinary time
The Pride of Edo: Tobi and the Fire Brigades by Paul Tierney
You set the price! Words: 20,170. Language: English. Published: May 23, 2013. Categories: Nonfiction » History » Asian
Fires were so common in Edo that they gave birth to a saying: "fires and fights are the flowers of Edo." The men who formed the backbone of Edo's fire brigades were both feared and admired. They were the pre-cursors to the Yakuza, Japan's mafia. An in-depth look at the development of Edo's fire brigades - the first of its kind in English - this book examines their birth and impact on the city.
The Teas That Bind by J. C. Greenway
Price: $3.99 USD. Words: 24,070. Language: English. Published: March 10, 2012. Categories: Essay » Political, Nonfiction » History » Asian
The Teas That Bind is the first book by Japan-based writer J. C. Greenway. It is a collection of posts which first appeared on the website ten minutes hate, about life in Japan before and since the Great East Japan Eathquake on 11 March 2011. It also includes a selection of contemporary sources and new material regarding fundraising and volunteering in Northern Japan.


text:
Michael Martinez Breaks Foot
Posted by Ian Riccaboni, Tue, March 20, 2012 05:26 PM | Comments: 29
Injuries, Posts
The hits just keep coming for the Phillies. Utility infielder Michael Martinez broke a bone in his right foot after being hit by a Jim Johnson pitch leaving Hector Luna and Pete Orr as the only utility infield options as Kevin Frandsen was optioned to the Minor League camp shortly after the game.
Luna has 313.1 career innings at shortstop but none since 2006; Orr has only played 44 innings at short and has not played there since playing 43 innings there for the Nats in 2008. Martinez's injury leaves the club presumably without a back-up shortstop for the immediate future and very thin up the middle. John Finger of Comcast reports that while no timetable has been given for recovery, this type of injury sidelines athletes for approximately 4-6 weeks.
Posts: 0 Terry Harmon
Galvis could shift to 2b… and they could play Orr or Wiggy at 2b… Not ideal… but it's the truth.
Posted: 05:42 PM on March 20, 2012
Posts: 0 Terry Harmon
Sorry… meant to say Galvis moves to SS not 2b.
Posted: 05:43 PM on March 20, 2012
Posts: 0 Matt
Galvis is a SS.
Posted: 11:04 PM on March 20, 2012
Posts: 0 BART SHART
It may be a blessing in disguise that Mini Mart is going to be out. It gives Galvis a window to strut his stuff. He may be way, way better than Mini Mart. And Mini Mart will only be out about six weeks anyway. Also, Hector Luna swings a much more potent bat than "Mart" and could be a solid offensive asset.
Posted: 07:33 PM on March 20, 2012
Posts: 0 Grismundo
His bat sucks and I don't trust his fielding, so my feelings are nothing more than "meh…."
Posted: 08:30 PM on March 20, 2012
Posts: 0 bacardipr05
Since he will only miss about 3 weeks of regular season time they come up with something. As teams make their cuts Rube could pick up someone if they think its necessary. Luna who looks to possibly make the team, more so now with the Chase and Mini Mart injuries has played SS. They could slide him over there in a pinch. Orr will probably get on the team as well.
Posted: 07:51 AM on March 21, 2012
Posts: 0 Bbusch
I saw Galvis play alot in reading the last few years his glove is unlike any I have ever seen his bat wil probably leave something to be desired but he will be better than mini mart or valdez just based on his feilding
Posted: 09:46 AM on March 21, 2012
Posts: 0 EricL
Signs of the apocalypse: A thread about a Michael Martinez injury generates >25 comments.
Posted: 01:43 PM on March 21, 2012
Posts: 0 schmenkman
And after that, no more comments — on anything — for the next 3 and a half hours.
Posted: 05:34 PM on March 21, 2012


text:
Page 1
Identification of differentially expressed microRNA in
parathyroid tumors
Reza Rahbari, MD1, Alisha K. Holloway, PhD2, Mei He, MD1, Elham Khanafshar, MD3, Orlo
H. Clark, MD4, and Electron Kebebew, MD1
1Endocrine Oncology Section, Surgery Branch, National Cancer Institute, Bethesda, Maryland
2Gladstone Institute University of California San Francisco, San Francisco, California
3Department of Pathology University of California San Francisco, San Francisco, California
4Department of Surgery, University of California San Francisco, San Francisco, California
Background—The molecular factors that control parathyroid tumorigenesis are poorly
understood. In the absence of local invasion or metastasis, distinguishing benign from malignant
parathyroid neoplasm is difficult on histologic examination. We studied the miRNA profile in
normal, hyperplastic, and benign and malignant parathyroid tumors to better understand the
molecular factors that may play a role in parathyroid tumorigenesis and that may serve as
diagnostic markers for parathyroid carcinoma.
Methods—MiRNA arrays containing 825 human microRNAs with 4 duplicate probes per
miRNA were used to profile parathyroid tumor (12 adenomas, 9 carcinomas, and 15 hyperplastic)
samples normalized to 4 reference normal parathyroid glands. Differentially expressed miRNA
were validated by real-time quantitative TaqMan PCR.
Results—One hundred and fifty six miRNAs in parathyroid hyperplasia, 277 microRNAs in
parathyroid adenoma, and 167 microRNAs in parathyroid carcinomas were significantly
dysregulated as compared to normal parathyroid glands (FDR < 0.05). By supervised clustering
analysis, all parathyroid carcinomas clustered together. Three miRNAs (miR-26b, miR-30b and
miR-126*) were significantly dysregulated between parathyroid carcinoma and parathyroid
adenoma. Receiver operative characteristic curve analysis showed mir-126* was the best
diagnostic marker, with an area under the curve of 0.776. MiRNAs are differentially expressed in
parathyroid neoplasms.
Conclusions—Most miRNA are downregulated in parathyroid carcinoma while in parathyroid
hyperplasia most miRNA are upregulated. MiRNA profiling shows distinct differentially
expressed miRNAs by tumor type which may serve as helpful adjunct to distinguish parathyroid
adenoma from carcinoma.
Parathyroid Carcinoma; MicroRNA; Parathyroid Neoplasm; Hyperparathyroidism; Parathyroid
Adenoma; Parathyroid Hyperplasia; Parathyroid tumors
Please address correspondence to: Electron Kebebew, MD National Cancer Institute Surgery Branch CRC, Room 4-5952 10 Center
Drive, MSC 1201 Bethesda, MD 20892-1201 Phone: (301) 496-5049 Fax: (301) 402-1788 email@example.com.
Declaration of interest: There is no conflict of interest.
NIH Public Access
Author Manuscript
Ann Surg Oncol. Author manuscript; available in PMC 2012 September 24.
Published in final edited form as:
Ann Surg Oncol. 2011 April ; 18(4): 1158–1165. doi:10.1245/s10434-010-1359-7.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 2
Hyperparathyroidism is characterized by hypersecretion of parathyroid hormone.
Hyperparathyroidism may be primary, secondary or rarely tertiary. Primary
hyperparathyroidism occurs as a result of inappropriate parathyroid hormone secretion from
enlarged parathyroid gland(s). Primary hyperparathyroidism is caused by a parathyroid
adenoma (85%), parathyroid hyperplasia involving 4 glands (10%), double parathyroid
adenomas (2–5%), or rarely due to parathyroid carcinoma (<1%)1. Secondary
hyperparathyroidism occurs as a response usually due to low serum calcium levels
associated with renal failure. In tertiary hyperparathyroidism, once the secondary cause of
hyperparathyroidism is resolved there is continued autonomous hypersecretion of
parathyroid hormone from an enlarged parathyroid gland.
Most parathyroid tumors in primary hyperparathyroidism are sporadic but approximately
5% are associated with autosomal dominant familial syndromes: Multiple Endocrine
Neoplasia types 1 (MEN 1; OMIM #131100) and 2A (MEN 2A; OMIM #171400), Familial
Isolated Hyperparathyroidism (OMIM #145000), and Hyperparathyroidism-Jaw Tumor
Syndrome (HPT-JS; OMIM #145001)2–4. Parathyroid tumors are heterogeneous and
histologic classification of tumors is often difficult. The pathologic distinction of
parathyroid adenoma from carcinoma is also difficult in the absence of obvious local
invasion and distant metastasis or disease recurrence5, 6. Moreover, if not grossly enlarged,
parathyroid glands can also be difficult to histologically classify as hyperplastic3.
Several responsible germline genetic changes associated with primary hyperparathyroidism
in familial syndrome have been identified (menin in MEN 1, RET in MEN 2A, CDC73/
HRPT2 in HPT-JS) but most cases of hyperparathyroidism are sporadic2, 7. Several genetic
changes have been implicated in a subset of sporadic parathyroid tumors. A chromosomal
rearrangement of the cyclinD1 gene to the parathyroid hormone gene locus occurs, and
cyclin D1 is overexpressed in up to 40% of sporadic parathyroid adenomas8. Recently,
mutation in the tumor suppressor gene HRPT2 has also been identified in sporadic
parathyroid carcinoma and a small subset of parathyroid adenomas6. Both the calcium
sensing receptor (CaSR) and vitamin D receptor (VDR) may also play a role in parathyroid
tumorigenesis4, 9.
MicroRNAs (miRNA, miR) are short, 19–22 nucleotides, non-coding RNAs. They account
for 1% of the genome, and play a role in cellular processes such as apoptosis, proliferation
and differentiation10, 11. MiRNAs are conserved across species and their expression is
highly specific for tissue type. MiRNA regulate gene expression through mRNA
degradation, translational modulation, and or gene silencing10, 12. Approximately, 30% of
the genome is regulated by miRNA. In general, miRNAs are downregulated in most
carcinoma and can function as either tumor suppressor or oncogene10, 12.
MiRNA profiling in several human malignancies have shown that such an approach may
identify miRNAs with a role in tumor cell biology, to classify tumor subtypes, and to
identify diagnostic and prognostic markers10. To further understand the molecular
mechanisms involved in parathyroid tumorigenesis and, thus, improve clinical diagnosis of
patients with primary hyerparathyroidism, we performed miRNA gene expression profiling
in 40 parathyroid tumor samples (9 parathyroid carcinomas, 12 parathyroid adenomas, 15
parathyroid hyperplasia, with 4 reference normal parathyroid glands).
Rahbari et al.
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Patients and Parathyroid tissue samples
Parathyroid tissue samples including clinical and histopathologic data were obtained for 40
patients with approval of the Committee on Human Research at the University of California,
San Francisco. Nine parathyroid carcinoma, 12 parathyroid adenoma and 15 parathyroid
hyperplasia were obtained from 40 patients who had primary hyperparathyroidism. The 4
normal parathyroid gland samples were obtained from biopsy specimens at the time of neck
exploration for parathyroidectomy. Cases of parathyroid carcinoma had Schantz and
Castleman's histologic criteria and all cases had local invasion, recurrence and or distant
RNA extraction and Microarray preparation
Total RNA was extracted from fresh frozen tissue. At the time that tumor samples were
sectioned for RNA extraction, representative portions of the tissue were examined by H & E
histology. The quality of total RNA was determined with the Agilent 2100 Bioanalyzer and
all samples had a RNA integrity number ≥ 7.0. MiRNA microarray profiling was done using
the miRCURY LNA array version 11.0 (Exiqon). This array contains 7,720 probes, 3,300 of
which represent 825 human miRNAs with 4 duplicate probes per miRNA. One μg of total
RNA for each sample and pooled normal reference were labeled with Hy3 and Hy5
fluorescent label, respectively, using the miRCURY LNA Array power labeling kit
(Exiqon), as described by the manufacturer. The Hy3-labeled samples and an Hy5-labeled
reference RNA sample were mixed pair wise and hybridized to the miRCURY LNA array.
The miRCURY LNA array microarray slides were scanned using the Agilent G2565BA
Microarray Scanner System (Agilent Technologies, Inc.), and the image analysis was carried
out using the ImaGene 7.0 software (BioDiscovery, Inc.).
Quantitative reverse transcriptase-PCR
MiRNAs were validated using quantitative reverse transcriptase-PCR. An adjusted p-value
controlling for false discovery rate (FDR) <0.01 was used to identify miRNAs that were
differentially expressed between adenoma and carcinoma. Thirteen out of the 24 miRNA
were commercially available. Quantitative reverse transcriptase-PCR was used to quantify
miRNA levels [hsa-miR-26b (assay# 000407), hsa-miR-27a (assay#000408), hsa-miR-27b
(assay# 000409), hsa-miR 30b (assay # 000602), hsa-miR-28 (assay# 000411), hsa-miR-34a
(assay# 000426), hsa-miR-100 (assay# 000437), hsa-miR-126 (assay# 000450), hsa-
miR-126* (assay# 000451), hsa-miR-145 (assay# 000467), hsa-miR-423-3P (assay#
002626), hsa-let-7a (assay # 000377) and hsa-let-7f (assay# 000382)] using primers and
probe purchased from Applied Biosystem (Foster City, CA). The gene expression pattern of
these tumors was compared with a reference sample that consisted of a pooled sample of
four normal parathyroid glands. Quantitative reverse transcriptase-PCRs (RT-PCR) for each
sample were done in triplicate. Total RNA (10 ng for 10μl reaction) was converted to cDNA
using primers specific for each miRNA and the TaqMan MiRNA reverse transcription kit
(4366597; Applied Biosystems), according to the manufacturer's instructions. All
quantitative reverse transcriptase-PCRs were done using a 5′ nuclease technique with
specific Taqman Gene Expression Assays (Applied Biosystems) and Taqman Universal
PCR Master Mix, NO AmpErase UNG (Applied Biosystems), on an ABI 7900HT Fast
Real-Time PCR System. MiRNA expression level was expressed as the difference (ΔCt)
between cycle threshold (Ct) for the miRNA of interest and pooled normal samples.
Rahbari et al.
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Target analysis
We conducted a literature search and identified genes of interest in parathyroid carcinoma.
The genes of interest were CDC73 (HRPT2, parafibromin), Rb1, Galectin 3 (Lgals 3), Ki-67
(MKI67), CCND 2, CASR or VDR3, 4, 8, 9. We then used the miR-Ontology data base from
Ferro Lab Data Mining and Informatics Group website that cross references Target Scan,
miRanda and PicTar data base to search for potential targets13.
Statistical analysis
The microarray GPR files were loaded into R/Bioconductor using the marray package
(Gentleman 2004). Flagged spots were removed from subsequent analysis and the remaining
probes were used for normalization and subsequent analyses. The log2 ratio of the intensity
of Cy5 to Cy3 signals were calculated for each miRNA on every array (with no background
subtraction) and normalized by print tip loess normalization14, 15. Since individual miRNAs
were represented by more than one probe on the array, the median of normalized log2 ratio
of the replicate probes (for those with more than one unflagged probe) was used as the value
for the miRNA. The summarized log2 ratios for each experiment were then used in
moderated t-statistics and p-value calculation using the limma package in R/
Bioconductor16, 17 with adjustment for false discovery rate using the Benjamini-Hochberg
method. A linear model with one factor, tumor type, with three groups (Adenoma,
Carcinoma and Hyperplasia) was established, followed by linear contrasts (Adenoma vs.
Carcinoma, Adenoma vs. Hyperplasia, and Carcinoma vs. Hyperplasia). Adjusted p-value
controlling for FDR using the Benjamini-Hochberg method were calculated. Unsupervised
clustering analysis was performed using hierarchical clustering of the top (50,100 and 200)
most variably expressed miRNAs based on the median absolute deviation using the
Euclidean distance as a similarity metric. Supervised clustering analysis using the random
Forest method in Bioconductor was performed using miRNAs that were uniquely
differentially expressed between Adenoma and Carcinoma. The quantitative reverse
transcriptase-PCR data was analyzed by using the XLSTAT statistical software. Pearson
correlation was used to compare the array data with the real-time PCR data with r>0.65
showing strong correlation. The Mann-Whitney U test was used to compare non-parametric
data between tumor types. Receiver operative characteristic curves were constructed using
the Wald two-tailed 95% confidence intervals with the Bamber continuity correction.
MiRNA Cluster Analysis
We analyzed miRNA expression in 9 parathyroid carcinoma, 12 parathyroid adenoma and
15 parathyroid hyperplasia normalized to 4 reference pooled normal parathyroid glands.
Unsupervised cluster analysis using the top 50 most variable miRNAs as defined by the
median absolute deviation showed two main groups with modest clustering by tumor type
Figure 1. Supervised cluster analysis using the random Forest method for differentially
expressed miRNA that were uniquely dysregulated in adenoma versus carcinoma
(FDR<0.05) showed complete clustering by tumor type Figure 2.
Differentially expressed miRNAs
We found that 277 miRNA were differentially expressed in parathyroid adenoma, 167 in
parathyroid carcinoma and 156 in parathyroid hyperplasia as compared to normal
(FDR<0.05) Table 1. We found some overlap in the differentially expressed miRNAs
between the three tumor types as compared to pooled normal parathyroid samples but 50
miRNAs were unique to parathyroid carcinoma, 122 to parathyroid adenoma and 22 to
parathyroid hyperplasia Figure 3A. The percentage of downregulated miRNAs unique to the
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three tumor types were significantly higher for parathyroid carcinoma (58%) and
parathyroid adenoma (50%) than for parathyroid hyperplasia (27%) (p <0.04). We also
found in parathyroid carcinoma there was greater fold change in the differentially expressed
miRNAs. In parathyroid carcinoma, 11 miRNAs (22.0%) were downregulated by greater
than 2-folds and 3 miRNAs (6.0%) were upregulated by greater than 2 folds. While for
miRNAs dysregulated in parathyroid adenoma and parathyroid hyperplasia, only 1 miRNA
for parathyroid adenoma was dysregulated by greater than 2 fold Table 1.
Because distinguishing between parathyroid adenoma and carcinoma is difficult by
histology, a comparison of miRNA expression differences between these groups was also
done. We identified 91 miRNA that were differentially expressed between adenoma and
carcinoma Figure 3B. The majority of these miRNA were downregulated (58.2%) with
nearly a fourth of the miRNA being downregulated by greater than 2 fold Table 2.
Validation of miRNA expression profile by TaqMan RT PCR
Using a FDR<0.01 from our microarray data we identified 24 differentially expressed
miRNA between adenoma versus carcinoma. Thirteen miRNAs were used to validate the
miRNA array expression data by real-time quantitative PCR. For 3 out of 13 miRNA there
was strong correlation with the array data (Table 2). Similar to our microarray data all 13
selected miRNA were downregulated in carcinoma compared to adenoma. Three of the 13
selected miRNAs were significantly downregulated between adenoma and carcinoma
(miR-126*, miR-26b, miR-30b, P <0.05) (Table 2). The area under the receiver operative
characteristic curve was determined for the 13 differentially expressed miRNA. The miRNA
with the highest accuracy was miR-126* (AUC=0.766).
Target analysis for differentially expressed miRNAs
We conducted a comprehensive target search for the 24 differentially expressed miRNA
between parathyroid adenoma and carcinoma that were used in the validation process. The
search included genes identified through literature search of genes involved in parathyroid
tumorigenesis. The genes of interest were CDC73/HRPT2, Rb1, Galectin 3 (Lgals 3), Ki-67
(MKI67), CCND 2, CASR and VDR3, 4, 8, 9. We used the miR-Ontology data base that cross
references Target Scan, miRanda and PicTar data base to search for potential targets13. In
our search we were able to identify the CDC73 gene as a predicted target for miR-28. We
further looked at the relationship between CDC73 expression and miR-28 using quantitative
RT-PCR and immunohistochemistry for CDC73 protein expression3. We found no
correlation between miR-28 expression and CDC73 expression in the parathyroid carcinoma
samples (data not shown).
In this study, we sought to determine if parathyroid neoplasm had distinct miRNA signature.
We found that the miRNA expression profile by unsupervised cluster analysis showed
clustering of most parathyroid carcinomas together. As expected, in the supervised cluster
analysis there was complete segregation of parathyroid samples by tumor type (parathyroid
adenoma versus parathyroid carcinoma). We further validated our results using RT-PCR.
Approximately two-thirds (9 of 13) of the miRNA expression levels showed good
correlation with the microarray data. All the validated miRNA had the same pattern of
downregulation in carcinoma compared to adenoma. Furthermore, miR-126*, miR-26b and
miR-30b were significantly differentially expressed between parathyroid adenoma and
parathyroid carcinoma by quantitative RT-PCR. MiR-126* levels was the most accurate for
differentiating between parathyroid carcinoma and parathyroid adenoma (71% sensitivity,
82% specificity).
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text:
Moving solid metallic targets for pion production in the Muon Collider/Neutrino Factory project
ABSTRACT The production of large fluxes of pions and muons using high-energy, high-intensity proton pulses impinging on solid or liquid targets presents unique problems which have not yet been entirely solved. We investigate the possibilities of using solid targets by choosing a metal of either extremely low thermal expansion coefficient or exceptionally high mechanical strength. Candidates are respectively Super-Invar and Vascomax 350 or Inconel 718. Moving targets in the form of chains or cables would be required for cooling purposes. These materials seem easily capable of surviving the beam pulses required for the largest beam power contemplated. Questions regarding radiation damage effects are being investigated.
Full-textDOI: · Available from: Peter Thieberger, Sep 27, 2015
- SourceAvailable from: Peter Thieberger[Show abstract] [Hide abstract]
ABSTRACT: The desire of the high-energy-physics community for more intense secondary particle beams motivates the development of multi-megawatt, pulsed proton sources. The targets needed to produce these secondary particle beams must be sufficiently robust to withstand the intense pressure waves arising from the high peak-energy deposition which an intense pulsed beam will deliver. In addition, the materials used for the targets must continue to perform in a severe radiation environment. The effect of the beam-induced pressure waves can be mitigated by use of target materials with high-yield strength and/or low coefficient of thermal expansion (CTE) [1, 2, 3]. We report here first results of an expanded study of the effects of irradiation on several additional candidate materials with high strength (AlBeMet, beryllium, Ti-V6-Al4) or low CTE (a carbon-carbon composite, a new Toyota" gum" metal alloy [4], Super-Invar).Particle Accelerator Conference, 2005. PAC 2005. Proceedings of the; 06/2005
Conference Paper: A High-Power Target Experiment[Show abstract] [Hide abstract]
ABSTRACT: We describe an experiment designed as a proof-of-principle test for a target system capable of converting a 4-MW proton beam into a high-intensity muon beam suitable for incorporation into either a neutrino factory complex or a muon collider. The target system is based on exposing a free mercury jet to an intense proton beam in the presence of a high-strength solenoidal magnetic field.Particle Accelerator Conference, 2005. PAC 2005. Proceedings of the; 06/2005


text:
Welcome, I am delighted to be writing to you as the newly appointed Acting Head teacher of Holy Family Catholic High School. It is a privilege to take up this position after serving the school for three years as the Deputy Head teacher. Mr Michael Fallon has been appointed as Acting Deputy Head teacher and he joins us from St John Fisher in Dewsbury.
This is an exciting time to take on such a role, as I strongly believe that Holy Family continues to be a truly excellent school. Our pastoral care is regarded as exemplary and once again this summer our academic achievements have continued to go from strength to strength. Holy Family is a place where staff are proud to work, a place which Governors and parents are proud to support and a school to which students are proud to belong.
Holy Family Catholic High School, is a school with a distinct ethos centred upon the life and teaching of Jesus Christ. The dignity of each person is at the heart of Catholic teaching; every student has his or her own individual strengths, gifts and talents; our aim is to ensure that these are all developed to their full potential.
We look for excellence in all aspects of learning and we expect high standards of achievement from all members of the community. We lead and innovate to make learning fun, challenging and distinctive. The relationships between teachers, students and parents are fundamental to the success of the school. Working together, we ensure that students enjoy their time at Holy Family, make outstanding progress and leave us as responsible, well-qualified, mature young people; ready to make a valued contribution to society.
We are looking to present a window into the life of the school, an opportunity to share information and to celebrate our students and their successes and as such I hope that you find the content of our website useful.
Our Open Evening is on Thu 24th September from 6pm onwards and if you are a prospective parent, we would like to invite you to visit our school on that evening. We do feel that our pupils are our real strength and if you would like to witness a working day at Holy Family please contact Mrs J Lemm who will be happy to arrange this for you.
I would like to thank you for your interest in our school and I look forward to the possibility of working together in the future.
Benedict Everett
Acting Headteacher
Latest News
GCSE Results 2015
- Details
This summer's outstanding results have set new records for Holy Family Catholic High School. The students have raised the bar even further, placing us well above national averages for all key performance indicators. The pupils in this particular year group were outstanding throughout their time at Holy Family, contributing massively to all aspects of school life and they richly deserve these exceptional results.
Both the pupils and their teachers were delighted with their performance and the students are now looking forward to successful futures in post-16 education. All school staff would like to offer their sincerest congratulations to the students and their families. This outstanding success can be attributed to the unique partnership which Holy Family develops between staff, students and their parents. The staff also deserve profound thanks and congratulations for their contribution; they go out of their way to help their students, always willing to go that extra mile.
September 2015 return to school
- Details
The School is open for Year 11 & Year 7 students on Tuesday the 8th of September. The rest of the school returns on Wednesday the 9th.
Monday the 7th of September is a teacher training day and the school is not open for pupils.
- Details
We are really excited to have received a grant from ASDAN which enables us to further support our pupil premium students and those working on alternative pathways. We have purchased a greenhouse in order to enable us to start on a horticulture project which also provides us with scope to incorporate business enterprise and to support the Food technology department.


text:
How agents, brokers and franchisors can use portals to drive productivity
Trulia CEO Pete Flint explains how agents, brokers and franchisors can drive productivity by working with Trulia and its subsidiary, Market Leader.
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text:
Benzle Porcelain"Porcelain: Color and Light" w/ Curtis Benzle La Meridiana, Tuscany, Italy. April 17-23, 2016. Colored Porcelain and Translucency. Lighting, Sculpture, Jewelry and more. Fun, Food and Fascination. benzleporcelain.com. Class Information: info@.lameridiana.fi.it. Questions: firstname.lastname@example.com.
Julie BrookRental WANTED: Living/ potting space in North San Diego County, CA from September/October on. Contact Julie: firstname.lastname@example.com.
Karen Korobow-MainRobert Brent SR-20 Slab Roller $500, does not include shipping. Located 1 hour north of Denver. (970)669-0333 or email@example.com.
Cub Creek FoundationJOSH DE WEESE WORKSHOP – Oct.31 – Nov.1 2015, Cub Creek Foundation, Appomattox, VA., $200. Meals included. Information at www.cubcreek.org or firstname.lastname@example.com.
Bradley UniversityThe 5th CTC exhibition is open to all ceramic artists over the age of 18 who currently reside in the Central Time Zone (including areas of Canada and Mexico within this time zone). All forms of ceramic expression created within the last three years are encouraged. The show will be judged by Verne Funk. Funk,… Read More »
Arkansas Art CenterRESIDENT ARTIST – Ceramics, Arkansas Arts Center, Little Rock, Arkansas. September 1, 2015 – August 31, 2016. Application deadline July 31, 2015. Please visit: https://arkansasartscenter.org/employment for details and to apply.
American Made ShowLearn what galleries want! Step by step guidance for design, development, pricing and pre-show logistics. New to Market Grants $700 Apply: AmericanMadeShow.com. email@example.com.
Baltimore Clayworks_PMIWORKSHOPS at Baltimore Clayworks; SUE TIRRELL- Folkloric Pottery with a Modern Sensibility, Sat–Sun Nov 7&8; Please visit www.baltimoreclayworks.org or call (410) 578 1919 x10.
Chrisholm PotteryAMAZING NORTHERN NEW MEXICO STYLE ADOBE HOME WITH BREATHTAKING VIEWS! Located off the scenic Turquoise Trail, this 1,754 sq. ft. off-grid passive and active solar home/studio with a detached 20′ x 24′ kiln shed was built in 2004. With 3 bedrooms / 2 baths it sits on 60 picturesque acres. The historic village of Madrid… Read More »
Ceramics Monthly June/July/August 2015
Working full time as a potter is a dream for a lot of people, and a reality for only some. It's not an easy career path, even if it is a rewarding and creative one. Working artists in general were on my mind when I traveled to the Republic of Korea last week to attend the opening for the Gyeonggi International Ceramics Biennale (GICB). I was a member of the biennale's International Committee, and in addition to the advisory work, and seeing the finalized exhibitions, I took part in a ceramics-focused tour. This gave me the opportunity to meet a few working potters in different parts of the country. We visited potters as they fired their wood kilns in Oegosan Onggi Village. We also had the chance to watch Heongyu Kim, who has made a living as a potter in Gyeongju for over 30 years, demonstrate how he uses traditional Onggi tools and techniques in his studio to make a variety of forms using earthenware clay. During our tour of Yido Ceramics in Yeoju, we met some of the many potters who worked in the small dinnerware factory and showroom. The six artists who are a part of this issue's working potters focus write about how they have combined their studio know-how with business and marketing skills (learned from mentors or on the job) and personal strengths.
–Jessica Knapp, editor.
Subscriber Extras (Subscribers can view this issue online!)
Read the full Letter From the Editor


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Hey guys.
Flipping is something that I personally love doing, and it therefore seems perfect that the third free ebook I give to this wonderful community is all about flipping products.
Printable View
Hey guys.
Flipping is something that I personally love doing, and it therefore seems perfect that the third free ebook I give to this wonderful community is all about flipping products.
thanks for the share
i'm always interested if hearing word "flip" --> flip site, domain, product
And flipping product is great way to get a big earning
anyway, i don't know what's the problem, my internet connection or the e-book. Because when i'm done, it's shown :
There was an error opening this document. Cannot decrypt....etc..
Hmm, that's odd, it works fine for me. Anyone else having any problems?
And, yeah, flipping is a great way of making loads of money online with minimal effort. I personally recommend all newbies to start with site flipping and some of my friends (all with no MMO experience) made hundreds of dollars within weeks :)
yes, i disagree that website flipping is for newbie. Site flipping need some skill such reasearch, good domain choosing, etc...and i think this is not a good option for newbie to start
your friend is newbie but practicing flipping site? The question is, is the site sell well?
And i think people who already can make site is not newbie anymore :D
Argh..!! don't know why, it's still error. can you upload it again? or do you think i'm the one who should reinstall browser?
And, regarding your technical issues, no one else seems to be experiencing them, so it probably is your end.
i think you can't threat him as newbie anymore. He is great, the beginning is so bright, how about future? I think he will be big someday
still error. then, because i can't read the e-book, i just wanna know. CMIIW, is flipping product 100% make the licensed and copyright moved to the buyer?


text:
The Swan Hotel
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On the road...side
... A flat battery to be specific. Mr RAC sorted that out and we thought we would spend a sunny Cotswold afternoon packing, repacking and deciding what wouldn't fit, just as soon as we attached the bike rack. The bike rack that is definitely the right make and model. The bike rack that is definitely 10cm too short to fit on our tailgate. Cue phone calls and internet trawling to find a solution. The manufacturer's suggestion was to bend the ...
Prologue (The day before)
... car and bike, all i own is, 2 storage boxes, 2 bin bags of clothes, a TV, PC and printer. Fact is, doesn't matter how little or long i'm gone for. I'm going to have to come back at some point. So don't see any reasoning behind selling everything. Not everything i own can even be bought again. Also, it wouldn't be cost effective to sell certain necessities now, only to have to buy them again upon my return. I'm just very ...
The Cotswold trip
... about time we got too hot. Great views today being up above the valley floor. About lunch time we ran into a food cart! This one was. Unique. It was a city bus that had tables set up inside between the seats and the kitchen area in the rear! We need one of these in Portland. The bus had just pulled into a car park and set up outside tables waiting for customers! Since we had packed lunches, we just got drinks and found a shady spot to sit for awhile. We arrived in Birdslip at ...
On the Road Again
... little village was the setting for the idyllic town in War Horse before the war started. It's hard to describe how quaint and beautiful it is. The buildings are all of the same stone and all have lovely gardens and climbing roses in bloom. It's very walkable and it just feels good. We wander about, stop at a local market for homemade orange marmalade and buy some cake from a table in front of a house on the honor system. I ...
... of a speech that Randolph had made in the house. In some regards we found the Palace a little austere when compared to say, Versailles, but thoroughly enjoyed our visit. Di loved the enormous library as the pipe organ at the very end was actually in use. Unfortunately the weather didn't allow us to visit the gardens. The bus driver / guide had scheduled us to have lunch at The Mermaid pub in the village of Burford. There was some confusion over the number of people who were ...


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February 14, 2014
Weight Watchers hits fresh 52-week low after results, levels to watch
The stock is down 25% to $22.94 at time of writing after the company last night reported earnings that fell short of expectations. Guidance for its FY14 came in well below consensus, with the company seeing FY14 EPS at $1.30 to $1.60, against consensus of $2.78. At current price next support is at the new 52-week low at $22.35, and then at $21.89. Resistance is at $23.52.
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Toronto cop dies after collision with motorist, tree
Const. John Zivcic, 34, remained in critical condition over the weekend and succumbed to his injuries Monday.
Join the discussion
PoliceOne top 5
- 1 Video: Ohio officer shot in ballistic vest, pleads with suspect to drop the gun
- 2 Reports: Ohio cop's shooting of boy who had pellet gun justified
- 3 Former cop leads protest after 'blacklivesmatter' written on coffee cup
- 4 Tension mounts between Baltimore police, prosecutors in Freddie Gray case
- 5 Ind. woman stops intruder with medieval combat skills, sword


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S.Con.Res.138 - A concurrent resolution expressing the sense of Congress that a day of peace and sharing should be established at the beginning of each year.106th Congress (1999-2000)
Concurrent ResolutionHide Overview icon-hide
|Sen. Wellstone, Paul D. [D-MN] (Introduced 09/21/2000)
|Senate - Judiciary | House - International Relations
|Latest Action:
|12/15/2000 Motion to reconsider laid on the table Agreed to without objection.
This bill has the status Passed House
Here are the steps for Status of Legislation:
- Introduced
- Passed Senate
- Passed House
Subject — Policy Area:
- Commemorations
- View subjects
Summary: S.Con.Res.138 — 106th Congress (1999-2000)All Bill Information (Except Text)
There is one summary for this bill. Bill summaries are authored by CRS.


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After growing up on mostly peas and butterbeans, Leah Morris McCormick of Bruce has discovered roasted asparagus.
Leah McCormick
Taylor Blue
"I just wanna cook!" Taylor Blue told her mother, Lisa, who asked, "What makes you happy?" following a meltdown after an ed psych final. Taylor, of Vardaman, started out as a journalism student, but didn't think she wanted to be told what she could and could not write, so she ventured into psychology.
Carmon Miller
"To me, a recipe is just a suggestion," said Carmon Miller of Calhoun City, and she doesn't really cook by them. But she has a ton of cookbooks, so many she "needs to quit buying them," she said, adding that the old ones are her favorites.
Cooper Caviness
Cooper Caviness of Calhoun City has always said he wants to be a chef. His twin brother, Conner, says he will own a restaurant in New Orleans and Cooper will be the chef.
Taneisha and Kaneisha Powell
2009 Bruce High School graduates Taneisha and Kaneisha Powell do a lot of meal cooking for their grandmother, Mary Jo Thomas, now and say she will eat anything they fix.
Carla Blackwelder
Carla Cannon Blackwelder made a New Year's resolution a few years ago to cook something new once a week, and said that is when she got her start cooking more.
Barry Black
Barry Black of Calhoun City learned to cook after he and Margaret married. He says what started it was a "discussion" over how to cook butterbeans, when hers "didn't taste like Mama's" (Jill Black).
Kristi Reid Shelton
Kristi Reid Shelton of Bruce is sharing "cherished recipes" of her grandmother, the late Tula Vance this week. She once told her grandmother she wanted a copy of her recipes, and about a year later for Christmas, Mrs. Tula gave her a notebook holding handwritten copies of them. Kristi said it took her grandmother a year to get them all written and put together. "Everyone (in the family) was mad," when Kristi was given the book, and her Mamow simply said, "She's the only one who asked for my recipes."
Alison and Phillip Beaty
"When I cook, I cook for an army," said Phillip Beaty of Bruce. He doesn't measure anything--he cooks by taste, like his mom, who is Korean.
Christy Scribner
"Santa came early to our house and brought me a Kitchen Aid stand mixer," said Christy Carr Scribner, of Eupora and formerly of Bruce. "It has a pasta maker, ice cream maker and meat grinder and we will have a lot of fun with it."


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Spanish in Jakarta – Spanish expats in Jakarta
InterNations worldwide » Indonesia expats » Jakarta expats » Spanish in Jakarta
Henrik Olsen
Living in Jakarta, from Norway
"I was amazed how many other members in Jakarta share the same interests as me. And some of them come from Norway, too ! "
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Living in Jakarta, from USA
"It's a really helpful site: Via InterNations, we found an international playgroup for our kids (6 and 8 years old) here in Jakarta."
InterNations - a trusted Network for Spanish in Jakarta
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InterNations - A Place for Spanish in Jakarta
¡Hola! to all Spanish in Jakarta! Would you like to meet fellow Spanish expats in Jakarta? Would you like to get insider suggestions from other Spanish, e.g. where in Jakarta your hometown team's next match is shown on TV or where to get paella?
We would like to invite you to become a member of InterNations Jakarta. As a member of InterNations, you will have access to an active group of Spanish expats, hailing from Madrid, Sevilla, Barcelona and all regions of Spain.
Spanish Expats in Jakarta Posted:
Hi, I just checked the link that Mark posted and looks nice, please let me know too if any of yo...
Could I join you guys? I'm member of elite gym but I don't have a partner for playing squash.
Re: Looking for townhouse to rent in Cipete
Hello, I am looking for a 2 bdr - townhouse for rent from September 2015 in Cipete area , or any s...
Hi, i´ve buy some stuff at Focus Nusantara. They have three shops in Jakarta, seem to have a comple...
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Hi guys!!! My name is David and I am from Barcelona. I just moved to Jakarta and I live near Gra...
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Hi everybody! I am new here and I'm a bit lost. I tried to find some info when I was living in Irel...
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With InterNations, Spanish expats in Jakarta are able to find both the help they need as well as lots of valuable information. The "Big Durian" offers so much for expats to explore - our community helps you enjoy your stay to the fullest.
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Our Jakarta community is also lively and welcoming offline. The InterNations Ambassadors host regular get-togethers and a range of expat activities, e.g. a chic dining experience in Jakarta's trendiest restaurant or a get-away with fellow Spanish expats to discover the ricelands, coffee plantations and volcanoes of Java. These activities make it easy for you to get to know other expats from Spain in your local community and meet Spanish in Indonesia in a comfortable setting. If this sounds interesting to you, simply sign up for membership – we are looking forward to welcoming you among our Spanish living in Jakarta!


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£650 pw
1 bedroom flat to rent Brock Street, Marylebone, London, NW1A beautiful modern apartment on the ninth floor of the Triton Building W1. The building benefits from a 24 hour concierge service and a lift. Conveniently located moments from the transport amenities of Warren Street and the open spaces of Regent's Park. Comprising 1 bedroom, 1 bathroom, open... More details ›
Added on 08/10/2015 by Knight Frank - Lettings, Marylebone. Call: 020 8012 4939 Local call rate
£350 pw
1 bedroom flat to rent Charlton Street, LondonOne bedroom garden flat to rent on Charlton Street/Camden Town More details ›
£1,000 pw
2 bedroom apartment to rent St Pancras Chambers, Euston Road, Kings Cross, London, NW1Outstanding 2/3 bedrooms 2 bathroom 1615 sq ft (150 sq m) 2nd floor apartment located in this great listed development above St Pancras International station. This large apartment offers a number of original features, 2/3 bedrooms, 2 bathrooms, fully fitted kitchen, reception room, high ceilings,... More details ›
Added on 08/10/2015 by Knight Frank - Lettings, Kings Cross. Call: 020 3324 9111 Local call rate
£1,085 pw
1 bedroom apartment to rent Churchway, LondonIsland Estates London are proud to present a luxurious one bedroom apartment in the heard of Euston. This property consists of a large one bedroom, a bright lounge and semi- open planned kitchen and a modernised bathroom and shower room. This luxurious apartment comes with great benefits... More details ›
£420 pw
1 bedroom flat to rent William Road, Camden, NW1Set within a new luxury development close to Warren Street tube is a super one bedroom apartment on the lower ground floor of a secure, gated, purpose built block. More details ›
Added on 08/10/2015 by Michael Charles Lettings, London. Call: 020 8012 4480 Local call rate
£670 pw
2 bedroom flat to rent Harrington Square, London, NW1A Beautiful, Newly Refurbished 3 Bedroom 3 Bathroom (2 En-Suite) Apartment - Fabulous Location - Located Moments from Mornington Crescent Station - Bright and Airy Open Plan Kitchen/Reception Room - 3 Bathrooms (2 x En-Suite) More details ›
£350 pw
1 bedroom ground floor flat to rent Chalton Street, London, NW1Beautiful large one double bedroom garden flat in private blockThe property comprises of a spacious living room with large double glazed windows which flood the room with lots of natural light. There are also doors leading on to the private gardenRecently fitted new kitchen complete with dishwashe More details ›
Added on 08/10/2015 by Harpens Residential, London. Call: 020 8012 6078 Local call rate
£260 pw
1 bedroom flat to rent Cumberland Market, London, NW1A four bedroom flat. Situated in a secure purpose built block, with lift access and a private balcony. Next to local amenities(NW1 3QE).*The rent includes all utility bills* *Unlimited Wi-Fi* *Monthly Cleaning Service* More details ›
£795 pw
3 bedroom house to rent Redhill Street, Regents ParkNewly refurbished three bedroom bungalow situated in a very sought after location. The property has been recently refurbished to a very high standard comprising three double bedrooms, spacious reception room leading onto a private garden, modern kitchen with built in appliances, separate utility ... More details ›
£210 pw
1 bedroom flat to rent Varndell Street, London, NW1A spacious DOUBLE bedroom with access to private balcony Room Let, situated in a 4 bedroom flat in this secure purpose built block near Warren Street(NW1 3QD).*Unlimited Wi-Fi* *ALL BILLS INCLUDED* *MONTHLY CLEANING* More details ›
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English Bulldog Father meets daughter first time
cancercrossNov 26 2013,
Tough english bulldog father meets even tougher daughter for the first time! This video is absolutley hilarious! ENJOY!
Follow us on twitter: Canterburybulls
Chaucer's Stud Service - to qualified bitches only!
Hello! Just wanted to send a special shout out to all our friends & fans! We have currently moved to a different location. Keep on sending your fan mail to us! We read through each one, and we Love it! Thank you! All other offers for (t.v. programs etc..) can be sent here as well!
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Cabinas la Catarata Reviews
La Fortuna, San Carlos, Alajuela, La Fortuna, Costa Rica
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Marthas Vineyard MA11 Howell Lane, South
Est. Mortgage: $/month
MLS Number 29242
- Residential
- Village Chilmark
- Square Feet 4000
- Bathroom 3
- Bedrooms 4
Nestled down Flanders Lane, this spacious, post-and-beam custom built contemporary home has an open and airy interior. This 4.68 acre property is the ideal retreat. Featuring four bedrooms, three and a half bathrooms (each with heated towel racks) and lovingly maintained landscapes. The Gourmet kitchen has top of the line appliances, 8 burner gas stove, built in booths as well as a formal dining area. Relax in the sauna, or read a book by the large brick fireplace in the living room. The outdoor space is perfect for entertaining company on the stone patio with views of the rolling backyard. A beautifully constructed outdoor shower and fully fenced expansive garden with raised beds also adorn this property. An Expansive attached garage (With radiant heated floors!), workshop, and so many other details embellish this home. All of this, plus only a short distance to swim, clam or kayak at your own private access on Menemsha Pond. With 200' of deeded frontage on Menemhsa pond and area for boat storage on the shore. This home is in immaculate condition with impeccable craftsmanship and is turnkey for you and your family.
Listed by Flanders Real Estate
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|Interest Rate
Est. Mortgage: $/month
Federal 30-year interest rate: 3.87% last updated on 2015-06-04
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