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|Items 41 - 60 of 68
Giving the Gift of Sight in the Maldives
It's been said that vision is not enough; it must be combined with venture. And recently we teamed up with the Israeli humanitarian organization Eye From Zion and MASHAV, Israel's Agency for International Development Cooperation, to actualize just that.Read More
Physical Rehabilitation Clinic Dedicated for Haiti's Amputees
Yesterday marked a tremendous stride forward for Haitian amputees and others severely injured by the earthquake: the dedication of a rehabilitation clinic and prosthetic workshop developed by JDC together with Israel's Magen David Adom and Sheba Medical Center at Tel Hashomer Hospital as well as the Haitian Red Cross and the HUEH (l'Hôpital de l'Université d'Etat d'Haïti). These modernized facilities are the first of their kind in Haiti.Read More
Seeing Haiti Through New Eyes
Trying to imagine that you are transforming someone's life in another country is no match for actually meeting the person whose life you're changing. That's why we were heartened that participants on the Jewish Federations of North America's recent mission to Haiti created a blog to share the impact that their generous donations—and that of tens of thousands of others—is having on the Haitian people. Echoing that sentiment, Gideon Hersher, JDC's representative in Haiti, reflects in the Jewish Journal of Greater Los Angeles on the progress being made on this devastated island as Rosh Hashanah approaches.Read More
JDC Continues Legacy of Providing Aid to Pakistani Disaster Victims
Pakistani flood victims who will be helped by JDC will join the ranks of tens of thousands of their fellow citizens whom JDC has reached with humanitarian assistance following natural disasters in Pakistan within the past five years alone.Read More
JDC Creates Emergency Relief Fund for Victims of Pakistan Floods
In response to the massive floods spreading across Pakistan, leaving destruction and desperation it its wake, JDC is collecting donations for its emergency Pakistan relief fund. Equipped with extensive disaster relief expertise, including humanitarian and development work after the 2005 and 2008 earthquakes in Pakistan, JDC is working closely with our partners on the ground to assess the most pressing needs in the affected areas.Read More
JDC Field Report on Russia's Heatwave
Recently back from Russia, Asher Ostrin, JDC's Former Soviet Union Regional Director, gives us an exclusive firsthand report on the impact of Russia's eco disaster on people in the region, and what we're doing to help.Read More
Haiti Communicates in Bright Colors
Back in January, about two weeks after the Haiti earthquake, Jacky, JDC's VP of the Board of Directors, went on the first JDC Haiti mission to the devastated country and, while there, blogged about the birth of a new project formed in partnership with Haitian NGO, PRODEV.Read More
Sri Lanka Floods: JDC Responds and Prepares for Future Rains
Last month, a severe series of heavy rains and subsequent flooding hit Sri Lanka, affecting hundreds of thousands of people living on the coast in the southwest part of the country. Sarvodaya (a partner since the 2004 Indian Ocean Tsunami), plunged itself into relief activities on the ground, coordinated by the Sarvodaya/JDC Community Disaster Management Center. They focused on meeting pressing needs—food, clean water, and medical care.Read More
Just Picture It – JDC: Helping Rebuild Haiti
As Haitians seek out solid ground to serve as a foundation for their homes, their families, and their futures, JDC and its partners are working to meet their most basic needs and rebuild. Check out a slideshow depicting how we are supplying water, medical care, and even schooling for thousands of people living in both Port-au-Prince and more remote areas.Read More
JDC Responds: Chile Earthquake
In the wake of today's 8.8 magnitude earthquake that struck Chile, JDC announced that it will collect funds for relief efforts.Read More
From Haiti, With Thanks
Numerous partnerships, two field missions, and more than $5.7 million raised encompass JDC's ongoing response to the January 12th earthquake that devastated Haiti. Our work has been captured in a video depicting scenes of heartbreak and glimpses of hope—hope made possible by JDC's generous supporters.Read More
One Month Later: Haitians Hold Vigil
JDC's Chief Operating Officer Judy Amit shares her observations from the ground on the one-month anniversary of the 7.0 magnitude earthquake that devastated more than 3 million of Haiti's residents.Read More
Helping Haiti Text by Text
JDC's Next Gen mobile giving campaign, launched at a Haiti earthquake fundraiser attended by young professionals, was just featured in The Jewish Week. Text "JDCHAITI" to 8-5-9-4-4 to donate $10 via cell phone.Read More
Seeing Haiti Through a Jewish Lens
The Jewish Exponent in Philadelphia published an op-ed on the Jewish response to the crisis in Haiti by JDC Board Member Betsy R. Sheerr. Here's some of what she had to say:Read More
Tae Kwon Do for Haiti
The situation in Haiti has certainly unleashed heartwarming generosity across all spectrums of age, income, and faith. There's no question that it has set their creativity soaring, as well—especially when it come to raising money. Check out this article from The Columbus Dispatch in Ohio about unusual, but heartfelt, student-driven charity. Matthew Rodier, a seventh-grader at Columbus Torah Academy and a black belt in tae kwon do, brainstormed a martial arts exhibition to raise funds for Haiti relief.Read More
JDC Haiti Mission: Tanks of Hope
Jacky, Vice President of JDC's Board of Directors, continues reporting from Haiti.Read More
Feeling Haiti's Pain from Chicago
JTA published a moving op-ed by Steven B. Nasatir, president of the Jewish United Fund/Jewish Federation of Metropolitan Chicago, on the crisis in Haiti. JUF is a JDC federation partner whose generous donation to JDC's Haiti Relief Fund is helping to aid victims on the ground.Read More
JDC Haiti Mission: Landing in Port-au-Prince
Jacky, Vice President of JDC's Board of Directors, continues reporting from Haiti.Read More
Power in Partners
As reports are coming in "hot off the blackberries" of JDC representatives on the ground in Haiti, we here in NY headquarters are learning that there is an almost instant connection and sense of camaraderie among the aid groups working in Port-au-Prince and the outlying areas. This is encouraging, since a united front will be a key to success in the impending rebuilding efforts of the weeks, months, and years ahead. Shortly after the earthquake hit, we were able to connect two of our field partners, the Israel Defense Forces' Medical Corps and Heart to Heart International—a move that benefited many quake victims, especially babies. Watch this video to learn more about the collaboration.Read More


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Dora (née Labonchere), Princess Odescalchi, Wife of Prince Gialma Odescalchi; daughter of Henry Labonchere
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While this mill could be used by all-grain brewers, who mill 10 to 15 pounds of grain per batch, it is not ideal for that purpose. In those cases we suggest a larger mill, such as our MILL400. For those brewers who have been around the block and know about the old Corona Mill, which looks similar to this mill, they are not the same! We put this mill through several tests on both function and grind quality before deciding to sell it.
- The mill runs off of two plates grinding together to crush the grain
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Boobalicious Celebrity Style
On one hand, Pam's body is insane. On the other, we can see her butt cheeks.
Yeah, we always look confused when we try to nail that hoochie-homeless combo, too.
Happy Anniversary, Will and Kate!
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Okazaki Daiichi Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Okazaki Daiichi Hotel
Travel Blogs from Okazaki
Two nights in Nagoya
The reason why I stopped in Nagoya was basically a train museum which showed the history of the Japanes trains with a main focus of the Shinkansen trains. I have to say that these trains have been fascinating me since I received a card game as a kid where the Shinkansen train card ...
... the winner we would win one point, otherwise the other person would win one point.
It turns out Philippe was much better at me picking which sumo would win! I don't know how he does it. He won the first category with 17 points and me 6 points and the second category 19 and me 4 points! Philippe basically guessed 80% of the time who would win the fight, over about the 60 fights that we saw over the 6 hours.. He must have been a ...
Nagoya, aka, Phil's day out!
... br> From here and after experiencing some bus confusion and hence delays we went to the Toyota Museum. I have to admit I thought this was going to be very blokey and I was just taking one for the team for the rest of the day, but this place was really interesting even though I was still ready to leave before the bloke!.
Who knew Toyota was first a weaving mill, then a weaving and spinning mill business that made a fortune during the second world war making ...
Day 7
Well today we started off early no breakfast met our tour guide just to get to the station by taxi. Caught the Shinkansen (bullet train) to Nagoya 350klms per hr took about 2 hrs fantastic had breakfast on the train which we bought before we got on. Met new guide Akiko who will be with us for 3 days. Next rapid express (120ksph) to Takayama about 2 hrs. We arrived in Takayama & went straight to our ...
Osaka - Nagoya - Home
... it, quickly figured out trains and got us there. Now onto Incheon Airport (have we mentioned it's the nicest airport in the world?) for a 4 hour layover and back home. E plays in the airport, dumbstruck by the South Korean parade in the airport and generally has a great time. H and I guzzle beers. Back to Seattle and Dottie!
Other places to stay in Okazaki
AB Hotel Okazaki107 Higashiarako, Hanecho, Okazaki | Hotelfrom $38
Okazaki New Grand Hotel515-33 Koseicho, Okazaki | Hotelfrom $80
Okazaki Sun Hotel2-22 Temna-dori, Okazaki | Hotelfrom $40
Okazaki Central Hotel34 Mimitori Myodaijicho, Okazaki | Hotelfrom $74
Green Hotel Rich Tokugawaen26 Kitsunezuka Myoudaiji-cho, Okazaki | Hotelfrom $55
Okazaki Ohwa Hotel3-7 Nakaokazakicho, Okazaki | Hotelfrom $78
Hotel Heisei3-52-2 Ueji, Okazaki | Hotelfrom $48
Business Hotel Sakuraso145 Itayamachi, Okazaki | Hotelfrom $48
Okazaki Daiichi Hotel East Building1-1 Karasawa-cho, Okazaki | Hotelfrom $34
Okazaki Single Hotel515 Koseicho, Okazaki | Hotelfrom $38
MyHotel Okazaki1-5-10 Hashira, Okazaki | Hotelfrom $73


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Trees in fall color. Photo by Grover C. von der Heyde [Oct 1948]
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Davenporters of Note: Norma M. Wiese
Posted on March 15, 2010 by SCblogger
Once upon the 1880s, in a beautiful brick Italian Villa at 709 Brown Street, lived William and Minnie Wiese, who were known for their love of travel, music, and community. Their daughter Edna was born in 1887 with another, Norma, … Continue reading →
Posted in Local History | Tagged Davenport Art Gallery, Norma M. Wiese, Social Organizations, Wiese Fine Arts Building, Women | 1 Comment


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Publications (363)1808.16 Total impact
Article: Abstract 2583: Refinement of inhibitors of the KRAS-signaling naocluster protein, CNKSR1, that block oncogenic KRAS signaling and growthCancer Research 08/2015; 75(15 Supplement):2583-2583. DOI:10.1158/1538-7445.AM2015-2583 · 9.33 Impact Factor
Article: Abstract 4448: Identification of a small molecule inhibitor of aldolase A for the targeting of hypoxic cancer cellsCancer Research 08/2015; 75(15 Supplement):4448-4448. DOI:10.1158/1538-7445.AM2015-4448 · 9.33 Impact Factor
Article: Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Clear cell kidney cancer (CRCC) is initiated typically by loss of the tumor suppressor VHL, driving constitutive activation of HIF-1 and HIF-2. However, whereas HIF-1 has a tumor suppressor role, HIF-2 plays a distinct role in driving CRCC. In this study, we show that the HIF-1α E3 ligase HAF complexes with HIF-2α at DNA to promote HIF-2-dependent transcription through a mechanism relying upon HAF SUMOylation. HAF SUMOylation was induced by hypoxia, whereas HAF-mediated HIF-1α degradation was SUMOylation independent. HAF overexpression in mice increased CRCC growth and metastasis. Clinically, HAF overexpression was associated with poor prognosis. Taken together, our results show that HAF is a specific mediator of HIF-2 activation that is critical for CRCC development and morbidity. Copyright © 2014, American Association for Cancer Research.Cancer Research 11/2014; 75(2). DOI:10.1158/0008-5472.CAN-13-2190 · 9.33 Impact Factor
Article: HNF4 is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer[Show abstract] [Hide abstract]
ABSTRACT: HRC, SN, and M-CK are equally contributed first authors. TP, HL, and YHK are equally contributed corresponding authors. ABSTRACT Background Worldwide, gastric cancer (GC) is the fourth most common malignancy and the most common cancer in East Asia. Development of targeted therapies for this disease has focused on a few known oncogenes but has had limited effects. Objective To determine oncogenic mechanisms and novel therapeutic targets specific for GC by identifying commonly dysregulated genes from the tumours of both Asian-Pacific and Caucasian patients. Methods We generated transcriptomic profiles of 22 Caucasian GC tumours and their matched non-cancerous samples and performed an integrative analysis across different GC gene expression datasets. We examined the inhibition of commonly overexpressed oncogenes and their constituent signalling pathways by RNAi and/or pharmacological inhibition. Results Hepatocyte nuclear factor-4α (HNF4α) upregulation was a key signalling event in gastric tumours from both Caucasian and Asian patients, and HNF4α antagonism was antineoplastic. Perturbation experiments in GC tumour cell lines and xenograft models further demonstrated that HNF4α is downregulated by AMPKα signalling and the AMPK agonist metformin; blockade of HNF4α activity resulted in cyclin downregulation, cell cycle arrest and tumour growth inhibition. HNF4α also regulated WNT signalling through its target gene WNT5A, a potential prognostic marker of diffuse type gastric tumours. Conclusions Our results indicate that HNF4α is a targetable oncoprotein in GC, is regulated by AMPK signalling through AMPKα and resides upstream of WNT signalling. HNF4α may regulate 'metabolic switch' characteristic of a general malignant phenotype and its target WNT5A has potential prognostic values. The AMPKα-HNF4α-WNT5A signalling cascade represents a potentially targetable pathway for drug development. INTRODUCTIONGut 11/2014; DOI:10.1136/gutjnl-2014-307918 · 14.66 Impact Factor
Article: 490 Potent and selective inhibitors of the KRAS-signaling nanocluster protein, CNKSR1, block oncogenic KRAS signaling and mut-KRAS cell growthEuropean Journal of Cancer 11/2014; 50:160. DOI:10.1016/S0959-8049(14)70616-1 · 5.42 Impact Factor
Article: A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer[Show abstract] [Hide abstract]
ABSTRACT: Although trastuzumab is a successful targeted therapy for breast cancer patients with tumors expressing HER2 (ERBB2), many patients eventually progress to drug resistance. Here, we identified subpathways differentially expressed between trastuzumab-resistant vs. -sensitive breast cancer cells, in conjunction with additional transcriptomic preclinical and clinical gene datasets, to rigorously identify overexpressed, resistance-associated genes. From this approach, we identified 32 genes reproducibly upregulated in trastuzumab resistance. 25 genes were upregulated in drug-resistant JIMT-1 cells, which also downregulated HER2 protein by >80% in the presence of trastuzumab. 24 genes were downregulated in trastuzumab-sensitive SKBR3 cells, Trastuzumab sensitivity was restored by siRNA knockdown of these genes in the resistant cells, and overexpression of 5 of the 25 genes was found in at least one of five refractory HER2+ breast cancer. In summary, our rigorous computational approach, followed by experimental validation, significantly implicate ATF4, CHEK2, ENAH, ICOSLG, and RAD51 as potential biomarkers of trastuzumab resistance. These results provide further proof-of-concept of our methodology for successfully identifying potential biomarkers and druggable signal pathways involved in tumor progression to drug resistance.Cancer Letters 11/2014; 356(2). DOI:10.1016/j.canlet.2014.10.038 · 5.62 Impact Factor
Article: Abstract 2671: Targeting the KRAS signaling naocluster protein CNKSR1 provides antitumor activity against mutant KRAS xenograftsCancer Research 10/2014; 74(19 Supplement):2671-2671. DOI:10.1158/1538-7445.AM2014-2671 · 9.33 Impact Factor
Article: Abstract 1781: Identification of focal adhesion and actin cytoskeleton regulation family genes as druggable target for gastric cancerCancer Research 10/2014; 74(19 Supplement):1781-1781. DOI:10.1158/1538-7445.AM2014-1781 · 9.33 Impact Factor
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ABSTRACT: The translation of high-throughput gene expression data into biologically meaningful information remains a bottleneck. We developed a novel computational algorithm, PATHOME, for detecting differentially expressed biological pathways. This algorithm employs straightforward statistical tests to evaluate the significance of differential expression patterns along subpathways. Applying it to gene expression data sets of gastric cancer (GC), we compared its performance with those of other leading programs. Based on a literature-driven reference set, PATHOME showed greater consistency in identifying known cancer-related pathways. For the WNT pathway uniquely identified by PATHOME, we validated its involvement in gastric carcinogenesis through experimental perturbation of both cell lines and animal models. We identified HNF4α-WNT5A regulation in the cross-talk between the AMPK metabolic pathway and the WNT signaling pathway, and further identified WNT5A as a potential therapeutic target for GC. We have demonstrated PATHOME to be a powerful tool, with improved sensitivity for identifying disease-related dysregulated pathways.Oncogene advance online publication, 31 March 2014; doi:10.1038/onc.2014.80.Oncogene 03/2014; 33(41). DOI:10.1038/onc.2014.80 · 8.46 Impact Factor
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ABSTRACT: Background & Aims: Farnesoid X receptor (FXR) is a bile acid nuclear receptor described through mouse knockout studies as a tumor suppressor for the development of colon adenocarcinomas. This study investigates the regulation of FXR in the development of human colon cancer. Methods: Immunohistochemistry of FXR in normal (n=238), polyps (n=32), and adenocarcinomas, staged I-IV (n= 43, 39, 68, and 9), of the colon and RT-PCR, reverse phase protein array (RPPA) and western blot analysis in 15 colon cancer cell lines, NR1H4 promoter methylation and mRNA expression in colon cancer samples from The Cancer Genome Atlas (TCGA), DNA methyltransferase inhibition, methyl-DNA immunoprecipitation (MeDIP), bisulfite sequencing and KRAS knock-down assessed were used to investigate FXR regulation in colon cancer development. Results: IHC and RT-qPCR revealed the expression and function of FXR was reduced in precancerous lesions and silenced in majority of stage I-IV tumors. FXR expression negatively correlated with PI3-kinase signaling and the epithelial-to-mesenchymal transition (EMT). The NR1H4 promoter is methylated in ~12% colon cancer TCGA samples, and methylation patterns segregate with tumor sub-types. Inhibition of DNA methylation and KRAS silencing both increased FXR expression. Conclusion: FXR expression is decreased early in human colon cancer progression and both DNA methylation and KRAS signaling may be contributing factors to FXR silencing. FXR potentially suppresses EMT and other oncogenic signaling cascades and restoration of FXR activity, by blocking silencing mechanisms or increasing residual FXR activity, represents promising therapeutic options for the treatment of colon cancer.AJP Gastrointestinal and Liver Physiology 10/2013; 306(1). DOI:10.1152/ajpgi.00234.2013 · 3.80 Impact Factor
Article: Abstract 3561: Silencing of farnesoid X receptor in human colon cancer by epigenetic mechanisms is associated with cancer progression.Cancer Research 08/2013; 73(8 Supplement):3561-3561. DOI:10.1158/1538-7445.AM2013-3561 · 9.33 Impact Factor
Article: Abstract 3836: A 3D high throughput RNA1 screen identifies the TLR4 kinase which alters spheroid architecture: a promising therapeutic strategy for pancreatic cancer.Cancer Research 08/2013; 73(8 Supplement):3836-3836. DOI:10.1158/1538-7445.AM2013-3836 · 9.33 Impact Factor
Article: Abstract 2157: Targeting the Maternal Embryonic Leucin zipper Kinase (MELK) in gastric cancers.Cancer Research 08/2013; 73(8 Supplement):2157-2157. DOI:10.1158/1538-7445.AM2013-2157 · 9.33 Impact Factor
- Cancer Research 08/2013; 73(8 Supplement):2076-2076. DOI:10.1158/1538-7445.AM2013-2076 · 9.33 Impact Factor
Article: Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [131I] analogue as useful PET tracers for PI3-kinase[Show abstract] [Hide abstract]
ABSTRACT: An improved method for the synthesis of 17β-hydroxy-16α-iodo-wortmannin along with the first synthesis of 17β-hydroxy-16α-iodoPX866 and [(131)I] radiolabeled 17β-hydroxy-16α-[(131)I]iodo-wortmannin, as potential PET tracers for PI3K was also described. The differences between wortmannin and its iodo analogue were compared by covalently docking each structure to L833 in PI3K.Bioorganic & medicinal chemistry 06/2013; 21(17). DOI:10.1016/j.bmc.2013.06.036 · 2.79 Impact Factor
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ABSTRACT: Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here we describe a novel tumor-stroma interaction that may help explain the prevalence of desmoplasia in this cancer. Specifically, we found that activation of HIF-1α by tumor hypoxia strongly activates secretion of the sonic hedgehog ligand SHH by cancer cells which in turn causes stromal fibroblasts to increase fibrous tissue deposition. In support of this finding, elevated levels of HIF-1α and SHH in pancreatic tumors were determined to be markers of decreased patient survival. Repeated cycles of hypoxia and desmoplasia amplified each other in a feed forward loop that made tumors more aggressive and resistant to therapy. This loop could be blocked by HIF-1α inhibition, which was sufficient to block SHH production and HH signaling. Taken together, our findings suggest that increased HIF-1α produced by hypoxic tumors triggers the desmoplasic reaction in pancreatic cancer, which is then amplified by a feed forward loop involving cycles of decreased blood flow and increased hypoxia. our findings strengthen the rationale for testing HIF inhibitors may therefore represent a novel therapeutic option for pancreatic cancer.Cancer Research 04/2013; 73(11). DOI:10.1158/0008-5472.CAN-11-1433 · 9.33 Impact Factor
Article: Abstract 5534: Metformin increases AMPKα activity by inhibition of AMPKα and cell cycle proliferation in Asian gastric cancer.Cancer Research 04/2013; 73(8 Supplement):5534-5534. DOI:10.1158/1538-7445.AM2013-5534 · 9.33 Impact Factor
Article: Abstract 3233: Modeling evolution of resistance in patient-derived xenografts: resistance to the BRAF inhibitor PLX4720.Cancer Research 04/2013; 73(8 Supplement):3233-3233. DOI:10.1158/1538-7445.AM2013-3233 · 9.33 Impact Factor
Article: Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents[Show abstract] [Hide abstract]
ABSTRACT: Purpose: Vemurafenib, a selective inhibitor of BRAF(V600), has shown significant activity in BRAF(V600) melanoma but not in less than 10% of metastatic BRAF(V600) colorectal cancers (CRC), suggesting that studies of the unique hypermethylated phenotype and concurrent oncogenic activation of BRAF(mut) CRC may provide combinatorial strategies. Experimental design: We conducted comparative proteomic analysis of BRAF(V600E) melanoma and CRC cell lines, followed by correlation of phosphoinositide 3-kinase (PI3K) pathway activation and sensitivity to the vemurafenib analogue PLX4720. Pharmacologic inhibitors and siRNA were used in combination with PLX4720 to inhibit PI3K and methyltransferase in cell lines and murine models. Results: Compared with melanoma, CRC lines show higher levels of PI3K/AKT pathway activation. CRC cell lines with mutations in PTEN or PIK3CA were less sensitive to growth inhibition by PLX4720 (P = 0.03), and knockdown of PTEN expression in sensitive CRC cells reduced growth inhibition by the drug. Combined treatment of PLX4720 with PI3K inhibitors caused synergistic growth inhibition in BRAF-mutant CRC cells with both primary and secondary resistance. In addition, methyltransferase inhibition was synergistic with PLX4720 and decreased AKT activation. In vivo, PLX4720 combined with either inhibitors of AKT or methyltransferase showed greater tumor growth inhibition than PLX4720 alone. Clones with acquired resistance to PLX4720 in vitro showed PI3K/AKT activation with EGF receptor (EGFR) or KRAS amplification. Conclusions: We show that activation of the PI3K/AKT pathway is a mechanism of both innate and acquired resistance to BRAF inhibitors in BRAF(V600E) CRC and suggest combinatorial approaches to improve outcomes in this poor prognosis subset of patients.Clinical Cancer Research 12/2012; 19(3). DOI:10.1158/1078-0432.CCR-11-1446 · 8.72 Impact Factor
Article: 406 PHT-782 an Inhibitor of the KRAS Signaling Nanocluster Protein CNKSR1 Blocks Oncogenic KRAS SignalingEuropean Journal of Cancer 11/2012; 48:123-124. DOI:10.1016/S0959-8049(12)72204-9 · 5.42 Impact Factor
Top Journals
Sanford-Burnham Medical Research Instituteلا هویا, California, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
- Department of Experimental Therapeutics
Mayo Foundation for Medical Education and ResearchRochester, Michigan, United States
Uppsala UniversityUppsala, Uppsala, Sweden
Georgetown University
Washington, Washington, D.C., United States
- Institute for Cognitive and Computational Sciences
University of Regina
Regina, Saskatchewan, Canada
- Department of Chemistry and Biochemistry
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
- Department of Chemistry
Mayo Clinic - Rochester
Rochester, Minnesota, United States
- • Department of Anesthesiology
- • Department of Oncology
The University of Arizona
Tucson, Arizona, United States
- • Cancer Center
- • Department of Pathology
University of HoustonHouston, Texas, United States
Arizona Research CenterPhoenix, Arizona, United States
University Hospital of Heraklion
Irákleio, Attica, Greece
- Department of Gastroenterology
University of GlasgowGlasgow, Scotland, United Kingdom
Johns Hopkins UniversityBaltimore, Maryland, United States
Georgia Institute of Technology
Atlanta, Georgia, United States
- School of Chemistry and Biochemistry


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Students blame racial profiling for broken up party
Police maintain that the party was loud and students refused to leave, late into the night
CBS Los Angeles
EXPOSITION PARK, Calif. — Some USC students say they were unfairly targeted Sunday morning when LAPD officers broke up a party and arrested several students. However, police say they were attacked by the students, who maintain they are victims of racial profiling.
Nate Howard, who hosted the party attended by minority students, said he planned the event not only to celebrate his four years at USC, but also for networking purposes. Howard was arrested and he believes it was because of his race.
An LAPD watch commander confirms the department received a noise complaint about Howard's party. He said party-goers refused to leave and threw beer bottles at arriving officers, which prompted them to return in riot gear, a charge Howard denies.
Full Story: USC Minority Students Allege Racial Profiling By LAPD After House Party
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Join the discussion
PoliceOne top 5
- 1 Video: Md. cop shoots, kills man who 'aggressively' advances towards him
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- 4 Numbers talk: Officers killed in the line of duty, people fatally shot by police
- 5 Fla. officer's finger nearly bitten off, suspect fatally shot


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HP announces converged storage strategy, products
Hewlett-Packard today announced a series of upgrades to its storage products, including the addition of data snapshots and a portfolio of pre-configured storage systems.
Hewlett-Packard today announced a series of upgrades to its storage products, including the addition of data snapshots and a portfolio of pre-configured storage systems.
Dell today announced a new appliance that allows its block-based storage area network (SAN) to store file-based data under one unified management interface.
In an acknowledgement of the severity of its recent computer compromise, RSA Security said Monday that it will replace SecureID tokens for any customer that asks.
Sales of external disk storage systems continue to boom with a fifth consecutive quarter of double-digit revenue gains, according to market research firm IDC.
EMC today formally announced a reseller partnership with MapR Technologies, a start-up that plans to sell a proprietary MapReduce product based on Apache Hadoop.
Only 10 per cent of large corporations are considering the public cloud as a place to store even their lowest tier of data for archive purposes, according to a survey by TheInfoPro, a market research firm.
Several big IT vendors, including IBM, Hewlett-Packard, BMC Software, Intel and Red Hat, announced this week that they are banding together to promote an open-source virtualization platform -- Kernel-based Virtual Machine (KVM) -- as an alternative t...
LAS VEGAS -- As corporate data stores continues to grow, in some cases by 50 per cent-plus a year, the expanding task of managing them and mining for information is forcing a change in how IT workers are trained.
* Company: EMC
LAS VEGAS -- As far as EMC CEO Joe Tucci is concerned, the future of his company is the hybrid cloud and big data analytics.
LAS VEGAS - EMC announced at its annual trade show today an upgrade to its data-caching appliance that allows storage arrays to replicate data between applications over distances greater than 2,000 miles.
The successful use of phishing emails to breach secure organizations like Oak Ridge National Laboratory and EMC's RSA security division is a stark reminder of the serious threat posed by a type of attack that was previously dismissed as low-tech.
LAS VEGAS - EMC Monday unveiled a purpose-built appliance for processing both structured and unstructured data sets for business analytics tasks.
LAS VEGAS -- As part of its strategy to touch just about every part of the private and public cloud infrastructure, EMC said today it will begin selling PCIe flash cards for servers to accelerate I/O to backend storage systems.
EMC subsidiary Iomega today unveiled a new series of simple disk storage arrays aimed at small-to-medium sized businesses and remote offices.
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First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.


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Explore Hotel今すぐご予約 ▼▲
Surf free Wi-Fi at our hotel in Northwest Atlanta
The Radisson hotel in Northwest Atlanta offers numerous amenities and services, including complimentary Wi-Fi and a well-equipped fitness center. Spend some time lounging beside our seasonal outdoor pool, or be productive using the 24-hour business center.
Also take advantage of our flexible meeting space, free daily newspapers and complimentary on-site parking.
Check-in: 3 p.m.
Also take advantage of our flexible meeting space, free daily newspapers and complimentary on-site parking.
The Radisson Atlanta Northwest offers these services and amenities:
- 218 rooms and suites
- Elements Restaurant & Bar
- More than 6,600 square feet of meeting space
- Nine meeting rooms, including a grand ballroom
- Fitness center open 24 hours
- Outdoor pool, open daily Memorial Day–Labor Day, 8 a.m.–10 p.m.
- 24-hour business center
- Parking (complimentary)
- Daily newspaper delivered to your hotel room (complimentary)
- Valet laundry service
- Wireless Internet access throughout hotel (complimentary)
Check-in: 3 p.m.
Check-out: Noon


text: Home Recipes Course Side Dish Recipes Pasta Side Dishes Share: Pasta Side Dishes Looking for pasta side dishes? Find delicious pasta side dishes including pasta salads, healthy pasta side dish recipes, and more pasta side dish recipes and ideas. Recipe Spotlight Makeover Slow-Cooked Mac 'n' Cheese Slow-Cooked Mac 'n' Cheese: the words alone are enough to make most mouths water. Shelby Molina's recipe is a clear example of comfort food at it's finest; it's rich, hearty and extra-cheesy. And because it's made in the slow cooker, it's also extremely easy. View Makeover Slow-Cooked Mac 'n' Cheese Recipe More Pasta Side Dishes Sort: Highest Rated Alphabetical Contest Winning Newest < prev | 1 | 2 | 3 | 4 | 5 | ... | next > Broccoli-Pasta Side Dish Broccoli-Pasta Side Dish I love to fix new recipes for my husband, Robert, and our children. With garlic and cheese, this is a tasty way to get kids to eat broccoli.—Judi Lacourse, Mesa, Arizona View Recipe Lemon Pasta with Spinach Lemon Pasta with Spinach Healthy spinach, garlic and lemon combine to coat angel hair pasta for a lovely side that'll freshen any meal. —Charlene Anderson, Bonney Lake, Washington View Recipe Moroccan Chicken Thighs Moroccan Chicken Thighs "My husband and I love Mediterranean and Middle Eastern food. This recipe has lots of flavor and is one of our favorites." Susan Mills - Three Rivers, California View Recipe Advertise with us ADVERTISEMENT Garlic-Buttered Pasta Garlic-Buttered Pasta This pasta goes nicely with any entree. Guests always leave a spot for it on their plates. It's great hot or served cold with fresh herbs from my garden.—Stephanie Moon, Boise, Idaho. View Recipe Noodle Rice Pilaf Noodle Rice Pilaf By adding a few fine egg noodles to a rice pilaf, you can have a deliciously different side dish. Terrific with fish, this dish also goes well with meat or poultry. —Kathy Schrecengost Oswego, New York View Recipe Spinach Penne Toss Spinach Penne Toss Spinach provides a delicious base for all the wonderful flavor combinations found in Kierste Wade's hearty salad. The Midland, Michigan reader writes, This salad is perfect for so many different occasions, including when company comes." View Recipe Garden Orzo Risotto Garden Orzo Risotto No one will believe this rich, creamy dish was prepared in less than 30 minutes! I developed the recipe when my garden tomatoes, zucchini and basil were coming on strong. Using orzo instead of Arborio rice makes the risotto so much easier to prepare. —Cindy Beberman, Orland Park, Illinois View Recipe Garlic-Herb Orzo Pilaf Garlic-Herb Orzo Pilaf "Mildly flavored and flecked with garlic and fresh herbs, this creamy, versatile side dish can accompany a wide variety of entrees. Plus, it's a cinch to put together." --Mary Relyea of Canastota, New York View Recipe Pepperoni Angel Hair Pepperoni Angel Hair This noodle side dish is so versatile that it can accompany steak, pork chops, chicken or even hamburgers. Chill leftovers to serve as a cool main-dish salad on a warm summer night. When time allows, I like to replace the pepperoni with sliced cooked chicken. -Julie Mosher, Coldwater, Michigan View Recipe Rigatoni Chard Toss Rigatoni Chard Toss I had to get my firefighter husband to eat more fruits and veggies to lower his cholesterol and triglycerides. Fresh chard and tomatoes add a lot of fiber and vitamins to our diets, but we love this recipe for the flavor. While he would never admit to eating "health food" around the firehouse, this dish is one of many that made his trips to the doctor much more pleasant! —Carolyn Kumpe, El Dorado, California View Recipe Roasted Veggie Pasta Roasted Veggie Pasta "My sister gave me this recipe years ago and it has become a favorite make-ahead and company meal. For a heartier dish, pair it with ham and dinner rolls." - Robyn Baney, Lexington Park, Maryland View Recipe < prev | 1 | 2 | 3 | 4 | 5 | ... | next > Advertise with us ADVERTISEMENT Advertise with us ADVERTISEMENT


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Ashwood Slab
Style: 36894327
An artisan board made of native Minnesota hard wood, this rustic slice was crafted by a family of woodworkers; resulting in a gorgeous serving piece, cutting board, or centerpiece paired with vases and votives. Each piece is carefully cured, sanded, and finished with food-grade mineral oil, making it moisture resistant and suited for both cutting and serving.
- Uses: serving piece, cutting board, centerpiece
- Sold individually
- Small: 7" diameter
- Medium: 9" diameter
- Large: 11" diameter
- Wood
- Handmade in USA


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Sounds like the good people of Farmersville do not want a muslim cemetery near their city. Texans threaten to 'cover land with pig blood' to block Muslim cemetery 25 miles from site of Muhammad cartoon shooting A proposal to bring … Continue reading
Share this:Facebook … Continue reading
Mohamed seen nodding in his brothel-in-the-sky. Christian girls abducted, raped, forcibly converted to Islam and now live as sex slaves/chattle to their new masters. Yeah, those hash tags really worked them over. Initially, 279 girls abducted from … Continue reading
It would suffice just to say that 'Islam' is the Nazism/Communism of our day. Åkesson: 'Islamism is the Nazism of our time' Photo: TT Published: 03 Aug 2014 09:42 GMT+02:00 Sweden Democrat leader Jimmie Åkesson kept to familiar themes … Continue reading
Doris Wise Montrose: One of the many ways that our Western Judeo-Christian civilisation can be shown to be superior to Islamic barbarism, is that when examined closely, Islamic culture is seen to be nothing but an impoverished subset of … Continue reading
Salvatore Cipolletta, whose daughter Cristina married young Yemeni Haidar Rohay Ahmed Al-Tawil, shot dead his son-in-law after seeing him butcher a lamb on the family's dinner table under his own grandchildren's eyes. Sheik yer'Mami (PBUH) has this one as … Continue reading
I invite anyone to comment on why Greenfield's statement isn't so. Daniel exposes for us one of the feckless, lying, mentally disturbed leaders of our day. I'm totally in favor of Mark Levin's suggestion for a mental evaluation for … Continue reading
Spain bows to Mecca after all these years. Like I said earlier, this is the kind of person that should be granted residency, and every Muslim with dual citizenship who believes that he should be deported, be repatriated to … Continue reading
To be filed under 'bullcrap'. Hmmmmm, incitement of 'racial' hatred over the publication of cartoons of a historical religious figure. If they manage to win with that obvious fallaciously devious claim, then what is to stop the communists from doing the same as … Continue reading
H/T: Vlad hahahahahahhahahaha Share this:Facebook … Continue reading
Shhhhhhh, the stamping out of free speech is done in the name of 'social cohesion'. But guess what? The council knows that these Christians won't be throwing firebombs and following council members to their homes to intimidate them, so … Continue reading
Thanks Cecilie for spurring me to republish this excellent video once again. Immerse yourself in it, dispels all the myths surrounding Rome's fall, the Dark Age and how 'golden' periods of Islamic rule was. Share this:Facebook … Continue reading
Share this:Facebook … Continue reading
File this one under "Islam Sucks". To really know Islam, is to truly laugh at it and be disgusted all at the same time. It all boils down to, milk and otherwise, to what Mohamed, the founder of Islam … Continue reading
THE RELIGION OF HATRED AND PIECES. UNSPEAKABLE SAVAGERY Share this:Facebook … Continue reading
Remember folks, this is the highly touted "moderate" Muslim majority state of Malaysia. No matter how you dice it, Islam keeps coming up fundamustard. KGS NOTE: If I were an ethnic Chinese or Christian living in Malaysia, I would begin … Continue reading
Folk, there's a whole lot of stuff in the hadiths that is so embarrassing for Islam that no Muslim wants that stuff getting out, but thankfully the Coptic priest with a gazillion fartwas on his head, Father Zakaria Botros, is there … Continue reading
This is the film the Tundra Tabloids … Continue reading
Over at the Australian Islamist Monitor, Syed Kamran Mirza, makes mention of a debate he had with a Bangladeshi Mullah scientist (Mullah scientist, isn't that like an oxymoron?) Dr. Sultan Ahmad, concerning women's rights in Islam. Mirza defeathers the Mullah … Continue reading
Big Peace: "So with a group of Muslims cruelly and despicably determined to raise a triumphalist mosque near the site of the Islamist atrocities of 9/11 in New York, the question naturally occurs: Does Islam suck?" Remember America, this may … Continue reading


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Perhaps the most exciting Graduation Celebration in our history. Check out this video of highlights from the Friday Evening Service.
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Peniel Graduation 2105What an amazing weekend!


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More Than 25,000 Bees Found Dead In Oregon Parking Lot
Approximately 25,000 – 50,000 bumble bees, along with honey bees and lady bugs were found found dead recently at a Target store parking lot in Wilsonville, Oregon. A Portland-based Xerces Society of Invertebrate Conservation was called to the scene to investigate. The bees were found clustered under dozens of European linden trees, the organization believes that the cause of death is likely attributable to acute pesticide poisoning, but are not 100 percent certain. It was recently discovered that that the linden trees were mistakenly sprayed on June 15 with Safari, a potent insecticide.
After several calls at the office I visited the Target store in Wilsonville and found a parking lot full of dead bumble bees underneath blooming European linden trees. They were literally falling out of the trees. To our knowledge this is one of the largest documented bumble bee deaths in the Western U.S. It was heartbreaking to watch – Rich Hatfield, conservation biologists with the Portland Xerces Society for Invertebrate Conservation
The Oregon Department of Agriculture (ODA) was also contacted, they are currently collecting samples to determine whether pesticides were used at the site. 50, 000 bees represents a loss of at least 300 colonies. Each of those colonies could have produced multiple new queens that would have gone on to establish new colonies next year. As we all know, bees are considered vital due to the fact that they are pollinators of many food crops.
What's worse is that the bees were killed during a 'National Pollenator Week,' a week aimed at celebrating the vital role that bees play in our ecosystem. This incident is the latest in a series of bee die-offs that has resulted in the decimation of 31% of the US bee population in 2013 alone. The large-scale erosion of bee populations poses a serious threat to the food supply.
It's hard not to ask whether Monsanto is enjoying this, it gives them another excuse to push the manufacturing of genetically modified foods (GMO).
Recently, the British Beekeepers Association (BBKA) recorded its worst losses of honeybees in history. The level of honeybee colony losses across England has more than doubled since last year, up to 33.8% from 16.2% in 2012. You can read more about that here. This is worldwide phenomenon.
It's the U.S. government's Environmental Protection Agency that approves of the GMO insecticide responsible for killing millions of bees. You can read more about that here.
Not to long ago, the US government was sued for their use of pesticides killing millions of bees, and ignoring scientific evidence that proves it. You can read more about that here.
The link between pesticides and bee deaths cannot be argued. It has been published in a number of peer-reviewed journals that show how widely used pesticides have a very damaging effect on bees. A new paper published in the journal Nature shows how bees are twice as likely to die when exposed to pesticides; two-thirds of the bees are lost when exposed compared to a third when not exposed. The exposed bees are also half as successful in gathering food. The exotoxicology tests only looked at honey bees, and failed to include bumblebees. Bumblebees are just as important in providing the required pollination to create much of the food we consume. You can read more in the journal Nature here.
There was also a study done by the NCBI which you can read here. This study also found that various groups of neonicotinoids are harming honey bees. They discovered that both clothianidin and and thiamethoxam persist in "extremely high levels" in planter exhaust material produced during the planting of crops treated with these insecticides. The research team also found neonicotinoid compounds in soil, including in fields where the chemicals were not even sprayed. They also found them in several plants and flowers visited by bees. Researchers determined that bees actively transfer contaminated pollen from primarily neonicotinoid treated corn crops, and bring it back to their hives. The bees also transfer these compounds to other plants and crops that are not treated with the chemicals, which shows just how persistent these chemicals truly are in the environment.
It's amazing how much information is surfacing within the past few years. Information regarding all sectors of society is emerging as the world continues to wake up. Those with the eyes to see, ears to hear and the heart to feel are responding. The bee insecticide debate should not be a debate anymore.
Find Out What Your Risk Of Cancer Is
While we all throw around the term "Cancer" loosely, do we really know what it is and what it means?
Have you ever wondered why, despite the billions of dollars spent on cancer research over many decades and the promise of a cure which is forever "just around the corner," cancer continues to increase?
Find out what your personal risk of getting cancer is with the fast 42 second quiz.
You can take the quiz here.
Find Out Your Personal Cancer Risk
Take this 42 second quiz to discover what your personal risk of cancer is. Take the quiz!


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The Tibet Policy Institute in collaboration with the Department of East Asian Studies, Delhi University and the Foundation for Non-Violent Alternatives is organizing a conference on August 21, 2015 at the University of Delhi Guest House to look into the health of the Tibetan Plateau. Invited scholars and experts …
Category Archive: Environment
Aug 08 2015
Only one Tibet to Quench Asia's Growing Thirst
Jun 08 2015
World Environment Day (WED) is the United Nations' principal vehicle to encourage worldwide awareness and action for environment. Over the years it serves as the 'people's day' for doing something positive for environment, starting individual actions into a collective power that generates an exponential positive impact on the …
Mar 14 2015
On the March 14 International Day of Action for Rivers, Tibetan Women's Association rejoice this day to remember the significance of Rivers in Tibet, lift our voices to celebrate rivers around the world and solute those who struggle to protect them. Tibet is the source …
Dec 05 2014
TWA at COP20, Lima, Peru
LIMA, Peru:
Central Tibetan Women's Association's Women's Environment and Development Officer Dorji Kyi and The Tibet Policy Institute's environment research fellow Tempa Gyaltsen are participating the ongoing UN Climate Change Conference or more popularly known as the COP20 at Lima, in Peru.
The COP20 or the Conference …
Jul 15 2014
TWA successfully wraps up its programs for the 33rd Kalachakra initiation held in Ladakh.
The Tibetan Women's Association and its global network of regional chapters successfully organized a series of actions during the 33rd Kalachakra initiation offered by His Holiness the Dalai Lama and held in Ladakh from July 03-14, 2014.
TWA organized a series of public discussions oriented towards advancing public …


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The MS Empress berthed at CT1 (Cruise Terminal 1) on the Admiralty Pier of the Western Docks, her bow pointing in the direction of the Western Entrance and English Channel beyond.
The photo was taken at 12.57 pm on Tuesday, 10th of May, 2011, from the upper level of the Admiralty Pier near the Admiralty Pier Turret (alt. Dover Turret: an enclosed Victorian armoured turret built in 1882).
The Empress is in the Inner Harbour (ex-Commercial Harbour) of Dover Harbour, bounded on the far side by the out-of-shot Prince of Wales Pier.
To the left of the passenger ship are the hills of the Western Heights, the western beginnings of the White Cliffs of Dover as they rise up from the River Dour valley to reach the lofty peak of Shakespeare Cliff (of King Lear fame), about 1800 yards behind the viewer.
In the background on the right-hand side of the photo is the concrete apron of the old Hoverport above which are two sections of the Victorian Waterloo Crescent: the new (for 2011) Dover Marina Hotel and Spa (ex-White Cliffs Hotel, ex-Churchill Hotel; ex-Shalimar Hotel end) and the Royal Cinque Ports Yacht Club (RCPYC). Waterloo Crescent is a Dover Listed Building.
The MS Empress is on a 10-night positional cruise from Lisbon to Copenhagen, taking the ship north for the 2011 summer season around the Baltic Sea. Full itinerary:
Lisbon, Portugal (04 May); Leixoes, Portugal (05 May); La Coruña, Spain (06 May); Bilbao, Spain (07 May); Le Havre (Paris), France (09 May); Dover, England (10 May); Ijmuiden, Holland/Netherlands (11 May); Hamburg, Germany (12 May); Copenhagen, Denmark (14 May).
Photos taken in 2010:
MS Empress before the White Cliffs of Dover at Daybreak
The MS Princess Daphne was also in port today but I was unable to get a picture:
General information for the MS Empress (1)
MS Empress is a cruise ship operated by Pullmantur Cruises. She was formerly operating for Royal Caribbean International (RCI) as Empress of the Seas. The ship was ordered by Admiral Cruise Lines and was intended to be called Future Seas and join the other Admiral Ships Azure Seas and Emerald Seas. However, Royal Caribbean merged with Admiral in 1987, the Admiral brand was dissolved and the newbuild (still under construction) was incorporated into the Royal Caribbean fleet.
The ship was originally named Nordic Empress and was the final RCI ship whose name did not end with "of the Seas". The name was changed to match the rest of the fleet (ie Empress of the Seas) following an extensive rebuilding that ended on 8 May 2004.
Nordic Empress was the first mainstream cruise ship especially designed for the 3 and 4 day cruise market. Her initial itinerary was short cruises to the Bahamas, which then were combined with 3 and 4 day cruises from San Juan, Puerto Rico. In 1999, following the sale of Song of America, _Nordic _ took over the New York (USA) to Bermuda route.
In 2000 Royal Caribbean announced that Nordic Empress would be undertaking a series of cruises in South America. Shortly after these cruises were put on sale, Royal Caribbean decided to replace Nordic Empress with Splendour of the Seas in the South American itineraries, leaving Nordic Empress in the Caribbean.
On 23 March 2007 it was reported that in March 2008 the Empress of the Seas would be transferred to the fleet of RCI's subsidiary Pullmantur Cruises. Her final voyage for Royal Caribbean took place on 7 March 2008. The maiden voyage as Empress for Pullmantur Cruises took place on 15 March 2008.
General characteristics (1):
Tonnage: gross tonnage (GT) of 48,563 tons
5,344 metric tons deadweight (DWT)
Length: 210.81 m (691.63 ft)
Beam: 30.70 m (100.72 ft)
Draught: 7.10 m (23.29 ft)
Decks: 11
Installed power: 2 × Wartsila-Duvant Crepelle diesels combined 16,200 kW
Speed: 19.5 knots (36.11 km/h; 22.44 mph)
Capacity: 1850 passengers
Crew: 668
Career (2) (3):
Name: 1990 - 2004: Nordic Empress; 2004 - 2008: Empress of the Seas; 2008 onwards: Empress
Owner: 1990 - 2008: Royal Caribbean International; 2008 onwards: Pullmantur Cruises
Operator: 1990 - 2008: Royal Caribbean International; 2008-present: Pullmantur Cruises
Port of registry: 1990 - 2002: Monrovia, Liberia; 2002 - 2008: Nassau, Bahamas; 2008 onwards: Valletta, Malta
Builder: Chantiers de l`Atlantique, Saint-Nazaire, France
Launched: 25th of August, 1989-08-25
Acquired: 31st of May, 1990-05-31
In service: 25th of June, 1990-06-25
Identification, IMO: 8716899
Call Sign: 9HJE9
Click to see all Cruise Ship photos (related tags: Boats, Ferries, Lifeboats, Navy, Sailing Ships, Ships, Tugs, and Workboats).
(1) Wikipedia entry for MS Empress
(2) Marinetraffic entry for MS Empress
John Latter / Jorolat
Dover Blog: The Psychology of a Small Town
This is the Images of Dover website: click on any red or blue "John Latter" link to access the Entry Page.
Click to see the third cruise ship in port on Tuesday, 10th of May, 2011:
When in range of AIS, the vessel's current position is shown at:
The Automatic Identification System (AIS) is an automatic tracking system used on ships and by vessel traffic services (VTS) for identifying and locating vessels by electronically exchanging data with other nearby ships and AIS Base stations. AIS information supplements marine radar, which continues to be the primary method of collision avoidance for water transport.
This photo also appears on the Pinterest Dover Cruise Ships board as:
MS Empress Cruise Ship, Admiralty Pier, Port of Dover, England
Photo taken in 22-24 Lord Warden Square, Dover, Kent CT17 9EQ, UK
Inner Harbour


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The aim of this paper was to describe and compare the methods used and the results obtained by the participants in a joint EADGENE (European Animal Disease Genomic Network of Excellence) and SABRE (Cutting Edge Genomics for Sustainable Animal Breeding) workshop focusing on post analysis of microarray data. The participating groups were provided with identical lists of microarray probes, including test statistics for three different contrasts, and the normalised log-ratios for each array, to be used as the starting point for interpreting the affected probes. The data originated from a microarray experiment conducted to study the host reactions in broilers occurring shortly after a secondary challenge with either a homologous or heterologous species of Eimeria.
Several conceptually different analytical approaches, using both commercial and public available software, were applied by the participating groups. The following tools were used: Ingenuity Pathway Analysis, MAPPFinder, LIMMA, GOstats, GOEAST, GOTM, Globaltest, TopGO, ArrayUnlock, Pathway Studio, GIST and AnnotationDbi. The main focus of the approaches was to utilise the relation between probes/genes and their gene ontology and pathways to interpret the affected probes/genes. The lack of a well-annotated chicken genome did though limit the possibilities to fully explore the tools. The main results from these analyses showed that the biological interpretation is highly dependent on the statistical method used but that some common biological conclusions could be reached.
It is highly recommended to test different analytical methods on the same data set and compare the results to obtain a reliable biological interpretation of the affected genes in a DNA microarray experiment.
The previous Microarray Data Analysis Workshop organised by EADGENE (European Animal Disease Genomic Network of Excellence, [1]) in November 2006, focussed on the analytical methods applied to raw microarray data to obtain lists of significantly affected genes. The results from the workshop were published in Genetics Selection Evolution [2-5]. This paper summarises the results obtained from a joint EADGENE and SABRE (Cutting Edge Genomics for Sustainable Animal Breeding, [6]) workshop in November 2008, focusing on the interpretation of lists of significantly affected genes, thereby extending the work from the previous workshop. The aim of the workshop was to evaluate and present existing methods and softwares, and potentially to propose new methods to deal with the post-analyses of microarray data, using real data sourced from within EADGENE and SABRE.
The initial objective of an analysis of a microarray data set is to produce a list of significantly affected probes/genes. This analysis can be relatively challenging, but the major challenge is to interpret the list of hundreds to thousand affected genes and draw some biological conclusions. To assist this process, a large number of statistical methods using quite different approaches have been proposed, which can consequently produce different results if applied to the same data set [7,8]. Gene-set analysis is a popular method and aims to identify differentially expressed gene sets associated with e.g. a phenotype of interest. Gene sets are commonly defined based on existing biological knowledge on gene function available from public databases, such as Gene Ontology (GO) [9,10], Kyoto Encyclopaedia of Genes and Genomes (KEGG) [11,12] and Gene Map Annotator and Pathway Profiler (GenMAPP) [13,14]. Current available tools for gene-set analysis have recently been reviewed by Huang et al [15] who define three classes of tools according to their underlying algorithms: singular enrichment analysis; gene set enrichment analysis; and modular enrichment analysis. Singular enrichment analysis (SEA) is a widely used approach, which utilises gene sets derived from Gene Ontology or pathway databases and investigates the enrichment of specific gene sets in a list of significantly affected genes, defined by applying a cut-off threshold value. SEA suffers from the use of a cut-off threshold value, the level of which has a major impact on the obtained results [16]. To avoid this problem, a group of methods termed gene set enrichment analysis (GSEA) have been developed, which utilise the information from all probes/genes in a microarray experiment. Modular enrichment analysis (MEA) is based on SEA but integrates term-term/gene-gene relationship to reveal biological meaning not revealed by single term/gene analysis.
A common challenge faced during the interpretation of the affected probes is the lack of appropriate annotation of the probes on the microarray. An affected probe without annotation can consequently not contribute to the interpretation of the results and if a major fraction of the probes are without annotation it may have a negative influence on the following analysis, such as GO enrichment analysis. A study of methods to improve the annotation of microarray probes was also a part of this workshop and is described in the adjacent papers [17-20].
In this paper, the methods applied and the results obtained by the participating groups are summarised and some general conclusions are drawn.
The data – host reactions in broilers after a secondary challenge
Eimeria are obligate intracellular protozoan parasites which can affect chickens and continuous exposure to Eimeria can result in protective immunity. The process leading to protective immunity was investigated by studying the host reactions after homologous or heterologous secondary infections. A total of 125 one-day-old Ross 308 male broilers were randomly divided in five groups of 25 broilers each. At 7 days of age, three groups were inoculated with phosphate buffered saline (P) and two groups were inoculated with E. maxima (M). A secondary challenge followed at day 21 of age. This challenge was with PBS (P), E. maxima (M) or with E. acervulina (A), forming five challenge groups PP, PM, PA, MM and MA. Five chickens from each group were killed at 8 and 24 hours after the second challenge and specific regulations of gene expression profiles in the jejunum were monitored using chicken whole genome oligonucleotide microarrays (ARK-Genomics Gallus gallus 20 K v1.0). The obtained microarray data was normalised and analysed and lists of affected genes were obtained for different contrasts. The result of the contrasts MM8-PM8, MM8-MA8 and MM8-MM24 were provided for this workshop as three lists including all microarray probes and test statistics for the three different contrasts. The number of affected probes for each contrast is shown in Table 1. The normalised log-ratios for each array were furthermore provided to the participating teams. The contrasts address different biological questions: differences between secondary and primary challenge (MM8-PM8), differences between homologous and heterologous challenge (MM8-MA8) and differences between two time points of a homologous challenge (MM8-MM24). The microarray data is available at the ArrayExpress database [21] under accession number E-MEXP-1972 and the three gene lists can be found as supplementary material to this paper (See Additional file 1). The data set used in this paper is part of larger data set, which includes additional time points, and a paper describing this complete set is in preparation by Rebel et al.
Additional file 1. Microsoft Excel spreadsheet file including the output from the statistical tests of the three contrasts MM8-PM8, MM8-MA8 and MM8-MM24 on separate worksheets. Each worksheet contains 13158 rows and the following columns: Block, Row and Column: block number and row-column number in block; Gene.Name: 384 well source plate number and well and reporter name from the annotation version 1.0 for ARK-Genomics G.gallus Oligo Probe set; Name.descr: reporter ID from the annotation version 1.0 for ARK-Genomics G.gallus Oligo Probe set; logFC: estimate of the log2-fold-change corresponding to the effect or contrast; AveExpr: average log2-expression for the probe over all arrays and channels; t: moderated t-statistic; P.Value: raw p-value; adj.P.Value: p-value adjusted for multiple testing (FDR); B: log odds that the gene is differentially expressed.
Format: XLS Size: 7.6MB Download file
This file can be viewed with: Microsoft Excel Viewer
Table 1. The contrasts used in the workshop. The number of significantly (FDR <= 0.05) affected probes for the three different contrasts used in the workshop.
Annotation of the chicken microarray probes
A proper annotation of the individual probes on a microarray is a prerequisite for establishing a link between the probe and the associated biological knowledge such as gene ontology and pathways. The annotation files used for interpreting the three provided gene lists were the ones obtained as a part of the workshop and described in the adjacent papers [17-20]. The most recent versions of the annotation files are available at the EADGENE Oligo Set Annotation Files homepage [22]. Version 2, released September 11th 2008, based on Ensembl version 50 was used for the workshop. Furthermore, the group from the Wageningen University built a customized annotation utilising chicken-human orthologous gene information and performed separate analyses for each annotation [23], the group from Aarhus University investigated methods for predicting the possible annotations for genes with unknown function from the expression data [24] and the participants from Institute for Animal Health based their analysis on an annotation obtained with the IMAD system (see [18] for additional details).
Analysis of the data
The participating groups applied conceptually different analytical approaches to interpret the three provided gene lists, using both commercial and public available software (Table 2). The main focus of the approaches was to utilise the relation between probes/genes and their gene ontology and pathways to interpret the affected probes/genes. The issue of correction for multiple testing was discussed by several groups. Additionally, as 2420 ENSEMBL chicken genes were found to be represented by multiple (up to nine) oligonucleotides on the chicken microarray, the effects of using the data from individual oligonucleotides or from the genes (represented by multiple oligonucleotides) were studied by the group from Aarhus University [24].
Table 2. Summary of the analytical approaches and choice of software for each group
Results and discussion
Annotation of the chicken microarray probes
The challenge of mapping the probes/genes on the chicken microarray to biological knowledge, such as gene ontology and pathways, was encountered by all groups. In general, half of the probes could be mapped and contribute to the biologically interpretation of the data. The lack of a well-annotated microarray did consequently have a detrimental effect on the results. Improvements were however obtained by using chicken-human orthologous gene annotation in contrast to chicken gene annotation as reported by the group from Wageningen University [23]. The chicken-human orthologous gene information resulted in a higher power to detect significant GO terms due to the higher coverage of GO terms assigned to human genes comparing to chicken genes, but as human and chicken are evolutionarily rather far apart care has to be taken when interpreting the obtained results [23]. The group from Aarhus University investigated methods for predicting the annotations of genes with unknown function from the expression data, and found that the methods may be of potential use, but that improvements in the chicken annotation, availability of larger microarray data sets and careful validation of the predictions are needed to fully utilise these methods [24].
Analysis of the data
The results of the different analytical approaches applied by the participating groups showed, in general, that the biological interpretation is highly dependent on the statistical method used.
The analysis for enrichment of GO-terms based on singular enrichment analysis (SEA), applied by the different groups (Table 2), revealed differences in numbers and identity of the GO-terms found to be affected. In general, many of the enriched GO-terms were found to be represented by few (1 or 2) genes. Applying the commonly used filtering criteria, requiring a reasonable number of genes, e.g. 10, to represent each GO-term, would lead to the conclusion that very few GO-terms are affected.
The commercial software Ingenuity Pathway Analysis (IPA) was used by the groups from University of Cordoba, Spain [25] and from INRA, Toulouse and Rennes [26] to explore the affected pathways. The results obtained by the two groups are quite similar even though the analyses were performed in different ways. In contrast to the group from University of Cordoba, the INRA group compared the networks of the three gene lists to the networks obtained from the complete list of genes on the microarray to identify significant networks relative to the microarray background.
Using GenMAPP/MAPPFinder, Prickett and Watson identified several biologically relevant pathways being affected, thus demonstrating the usefulness of this tool for microarray analysis, especially with an improved annotation [27].
The analytical methods based on gene set enrichment analysis (GSEA) (GlobalTest applied by the groups from ASG [28] and DJF [24]) did in general result in a larger number of terms to be significant than found using the SEA based methods. This was expected as theoretical considerations indicate that this method is more powerful [29].
The tool topGO belongs to the modular enrichment analysis (MEA) class of methods and takes the GO structure into account when testing the gene sets. Comparing the results obtained using topGO with the results from "classical" Fisher's exact test and the Kolmogorov Smirnoff test, both of which ignore the GO structure, showed that fewer significant terms were found with topGO [24], which may indicate increased specificity [30].
The majority of the analytical tools provide options for correction for multiple testing using various methods. It is common practice to apply multiple test correction to control the family-wise false-positive rate in the result list, but there is little consensus on how to perform the correction and whether the correction improves the results [15]. Several groups applied some methods for correction for multiple testing during their analysis of the data for this workshop, and found only a few significant terms/pathways after correction [24,27,28]. The essential problems are that the structure of the GO graph and pathways are in conflict with the assumption of independence and that most methods for multiple test correction do not change the ranks and therefore the relative importance of the different GO terms [24].
Where genes are represented by one or more oligonucleotides, it is possible to carry out enrichment tests at the level of the gene or at the oligonucleotide. These two levels could potentially produce different results. However only minor differences were found between enrichment tests at the level of the gene compared to those at the level of the oligonucleotide [24]. It is difficult however to generalize this result to other datasets but if the number of replicate probes varies for different genes it will often be better to use gene-based tests.
Despite differences in the specific GO-terms and pathways found to be affected by the groups, some common biological conclusions could though be reached for the three contrasts. Specific details of the biological conclusion can found in the papers from the participating groups [23-28]. The interpretation of the genes affected between MM8 and PM8 shows, as expected, that a secondary immune response is induced by the homologous challenge while the heterologous challenge induces a primary immune response. The lowest number of affected genes was found when comparing the expression profiles from homologous and heterologous challenge (MM8-MA8, table 1). This indicates that an E. acervulina infection triggers a similar response as an E. maxima infection. The identity of the affected genes between different time points of a homologous challenge (MM8-MM24) indicates that the secondary immune response increases from 8 to 24 hours.
Different analytical methods were applied by the teams of the joint EADGENE and SABRE workshop focusing on the extraction of biological meaning from lists of significantly affected genes. The analyses were in general negatively affected by the lack of a well annotated microarray. However, the use of chicken-human orthologous gene annotation was found to improve the analyses. The results showed that the biological interpretation is highly dependent on the statistical method used but that some common biological conclusions could be reached. It is hence recommended to test different analytical methods on the same data set and compare the results to obtain a reliable biological interpretation of the affected genes in a DNA microarray experiment.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
JH drafted the manuscript and all authors read and approved the final version of the manuscript.
The authors wish to acknowledge Caroline Channing and the other organisers for organising the workshop, Dr. Rebel and colleagues from Animal Science Group in Lelystad, The Netherlands, for providing the microarray data from the chicken infection experiment, the reviewers for valuable comments and EADGENE and SABRE for financial support.
This article has been published as part of BMC Proceedings Volume 3 Supplement 4, 2009: EADGENE and SABRE Post-analyses Workshop. The full contents of the supplement are available online at http://www.biomedcentral.com/1753-6561/3?issue=S4.
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text:
Ismat Sarah Mangla
Roman Catholic Church Gets PR Boost From Pope's US VisitA Pew Research survey finds that Pope Francis' trip to the U.S. has generated positive feelings for the Catholic Church.
Ten Commandments Monument Off Oklahoma Capitol GroundsSecularism activists say the removal was an important move in the culture wars.
Mosques Brace For Planned Anti-Islam ProtestsWith 20 anti-Islam rallies planned for Friday and Saturday, community leaders are meeting with law enforcement to encourage vigilance.
Key Facts About The Catholic Church's SynodThe three-week meeting of bishops will focus on church teachings about family in the context of contemporary life.
The Pope Met With Gay A Couple Before He Met Kim DavisDuring a private meeting in Washington, Yayo Grassi, a gay former student of the pope's, brought along his partner of 19 years.
Suddenly, Muslim Fashion Market In StyleMore retailers and designers are catering to the tastes of Muslims, who are expected to spend more than $484 billion globally on clothing by 2019.
Eid Al-Adha Around The WorldMuslims celebrated Eid all over the world this week, from France to India to Iraq.
When Religious Tourism Turns DeadlyThursday's stampede near Mecca has raised concerns that the Saudi government is prioritizing tourism over public safety.
Not Even The Pope Can Bridge US Political DivideResponses to Pope Francis' historic address to Congress on Thursday were predictably split along party lines.
'It Feels Like A Real Holiday'On Thursday, New York City public schools will close to mark Eid al-Adha -- and many Muslim families are hailing the decision.
Pope's Views Create Dilemma For Some GOP CandidatesCatholic Republican politicians are faced with the decision of either aligning with the leader of the Catholic Church or appealing to their far-right base.
A Balance Of Competing PowersPope Francis arrived in the U.S. to find himself in the nexus of global capitalism -- as far from the periphery as he could get.
Tumblr Helps LGBT Catholics 'Tell The Pope' Their StoriesA gay rights group started a campaign urging members of the LGBT community to tell their stories to Pope Francis.
Fundraising Campaign To Send Texas Teen To MITA new online campaign aims to raise college funds for Ahmed Mohamed, the Texas ninth-grader who was arrested for bringing a homemade clock to school.
Pakistan Bus Stop Explosion Kills At Least 10No group has claimed responsibility yet for the attack, which is being investigated by authorities.
Iran President To Jews: L'Shanah TovaHe sent the new year's greetings just before the Rosh Hashana holiday, which begins at sunset Sunday.
Secret Service Diffused Security Threat Against PopeWhile he didn't disclose details, the Homeland Security House Committee co-chairman said Sunday that the Secret Service stopped a potential attack.
Nearly A Third Of Americans Believe Obama's MuslimThough the president repeatedly has said he is a practicing Christian, rumors about his practicing Islam still persist.
Comic Con Screening Divides 'X-Files' FansFox will screen the first installment of the new "X-Files" at New York Comic Con in October, but not all fans are happy about it.
New Emojis For The FaithfulApple's 9.1 mobile operating system update will feature a host of new emojis, including a mosque and a synagogue.


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Although hailed as the only blind comic on the stand up circuit, comedian Chris McCausland makes light of it. He usually begins with a crack about the irony of a blind man doing observational comedy and then speeds off into his entertaining and refreshing set, making wry and perceptive comments about the rich and famous, every day life and suchlike. Instantly likeable and definitely memorable.
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Understanding the maturation of corporate VC–VCJ guest Q&A
David Teten of ff Venture Capital interviews Mari Joller on how corporates are innovating and impacting venture capital.
David Teten of ff Venture Capital interviews Mari Joller on how corporates are innovating and impacting venture capital.
VCJ guest column: An increase in corporate VC is proving good for the overall health and vitality of the entrepreneurial ecosystem.
The last several years have seen a push by corporations in America and elsewhere to get involved in venture investing. According to a new study, more than 40 percent have IRRs of 10 percent or greater on their portfolios.
Spring is four months away, but love is in the air. At least in the venture business. With the success of dating app Tinder, VCs are hot to find another match-making hit. They have poured more than $70 million into more than a dozen such sites, including Coffee Meets Bagel, Hinge, and theComplete.me, according to peHUB's No. 1 VC post this week.
SAP Ventures renamed itself Sapphire Ventures on Thursday to emphasize its independence from its sole limited partner, SAP.
Trending this week in venture capital: AltspaceVR, Apropose, Liquid Light, Livongo Health and Mediamorph pull in fresh capital.
VC stories trending this week on peHUB: Salesforce targets mobile enterprise startups with new $100 million VC fund, investors bet big on smart homes, and Kleiner Perkins leads huge round for DataStax.
There are three main reasons why next-generation corporate VCs who are practicing today are fundamentally different from their predecessors, and why they will be a driving force in the venture industry for many years to come, says guest columnist William Taranto, president of Merck Global Health Innovation Fund.
The corporate venture arm SAP Ventures plans to build out internal business development team to assist portfolio companies.
GlaxoSmithKline on Thursday announced a $50 million venture fund and said the fund's first investment was made in SetPoint Medical, which is working on implantable devices to treat inflammatory diseases, Reuters reported.
The acquisition today of ecoATM by Outerwall helps demonstrate that corporate venture capital funding is alive and well, says guest columnist Randy Hawks of Claremont Creek Ventures.
Corporate investors during the first half of the year participated in 16.3% of venture deals, according to a new study. This is an increase from 14.7% in 2011 and 12.9% in 2010.
In total corporate investors poured $2.3 billion in 551 deals in 2011, up 15% in both dollars and deals, the MoneyTree Report shows.
Corporate venture capital comes and goes in waves. In good times, money flows easily into startups. When times turn bad, most corporate investors disappear, and the waves they create crash violently on the shore. It doesn't have to be this way. Corporations have the resources and potential to make venture a long-term strategic asset. The […]
Intel Capital is maintaining a strong investment pace this year with fundings of as much as $500 million possible by year's end, a spokesperson said. Investments are presently at $419 million and the pipeline of deals could bring the year's total to the half a billion dollar mark, the organization told peHUB. Intel Capital is […]


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Renault Twingo hatchback
Price £9,495 - £13,445
- Stylish design
- Very manoeuvrable
- Good rear passenger space
- Wind noise at speed
- Not much fun to drive
- More expensive than rivals
At a glance
- The greenest
- Dynamique SCe 70 S&S eco2 5dr £10,995
- The cheapest
- Expression SCe 70 5dr £9,495
- The fastest
- Dynamique ENERGY TCe 90 5dr £11,695
- Top of the range
- Dynamique S TCe 90 Auto 5dr £13,445
"The new Renault Twingo is a good-looking, quirky and practical city car."
The Renault Twingo competes with city cars including the Skoda Citigo, Kia Picanto and Hyundai i10. However, unlike those models, which have their engines mounted in the front, the Twingo's engine is in the back. This makes it shorter than most cars, yet just as spacious inside. The front wheels can also turn more freely, so it has a tighter turning circle – which is great when you're driving in town.
Ensuring it makes the most of its dinky size, the Twingo is available with a choice of two small but reasonably powerful petrol engines. However, they're quite different in character, with the larger SCe70 being slower but still responsive around town. Meanwhile, the smaller turbocharged TCe 90 is a lot more powerful and a better all-rounder – it's good in town and on the open road. However, it's only available in the more expensive Dynamique and Dynamique S trim levels. Prices for these start at around £12,000, which is more than you'll pay for one of our favourite city cars – the Skoda Citigo.
Whichever engine you choose, the Twingo is reasonably comfortable, but not especially fun to drive. In this respect, the Volkswagen up! and Hyundai i10 are more entertaining. Visibility is good (at least for those in the front) and the cabin is reasonably roomy. The boot is quite small, but you can make it larger by folding down the rear seats. You can fold down the front passenger seat backrest, too, enabling the car to carry longer loads.
There are four trim levels, starting with Expression and moving through Play and Dynamique, to Dynamique S. Expression is well equipped, with DAB digital radio, electric mirrors, LED daytime running lights and side protectors, but Play gets our vote thanks to additional features such as air-conditioning and driver's seat height adjustment.
The problem is that Expression and Play are only available with the less powerful SCe 70 engine. However, they just dip under the £10,000 mark. There are plenty of opportunities to brighten up your Twingo with personalisation and equipment packs, but don't go over the top or you'll lose even more money when you sell the car.
Renault's reliability record is improving and any lingering doubts should be taken care of by the company's impressive four-year/100,000-mile warranty. The Twingo scored only four out of five stars in Euro NCAP's latest crash tests but it has decent standard safety kit, including tyre pressure monitoring, electronic stability control, hill-start assistance, emergency braking assistance and four airbags.
MPG, running costs & CO2
Two small engines will be cheap to run
Engines, drive & performance
Very good in town, but not as much fun to drive as rivals
Interior & comfort
Interior is modern and practical, but can be noisy
Practicality & boot space
Relatively spacious interior and practical boot
Reliability & safety
All-new car, but we expect good things


text:
Updated 10/23/2014
This shimmering blue-green inlet surrounded by cliffs is what first attracted everyone to La Jolla, from Native Americans to the glitterati. "The Cove," as locals refer to it, beyond where Girard Avenue dead-ends into Coast Boulevard, is marked by towering palms that line a promenade where people strolling in designer clothes are as common as Frisbee throwers. Ellen Browning Scripps Park sits atop cliffs formed by the incessant pounding of the waves and offers a great spot for picnics with a view. The Cove has beautiful white sand that is a bit course near the water's edge, but the beach is still a great place for sunbathing and lounging. At low tide, the pools and cliff caves are a destination for explorers. This is also the best place in San Diego for snorkeling, and snorkelers can spot bright-orange Garibaldi fish and other marine life in the waters of the San Diego–La Jolla Underwater Park Ecological Reserve. The cove is also a favorite of rough-water swimmers. Amenities: lifeguards, showers, toilets. Best for: snorkeling, swimming, walking.
1100 Coast Blvd., east of Ellen Browning Scripps Park, San Diego, California, 92037, United States
Updated 10/23/2014
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