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- July 09, 2015
09 Jul'15
Limited public preview opens for Azure SQL Data Warehouse
Microsoft opened the preview of Azure SQL Data Warehouse, a petabyte-scale, distributed columnar data warehouse service with massively parallel processing.
- May 12, 2015
12 May'15
SQL Server 2016 preview announced for summer 2015
Microsoft CEO Satya Nadella announced the SQL Server 2016 preview for this summer. Its new features model the ethos of "mobile first, cloud first."
- May 07, 2015
07 May'15
Will the R language benefit from Microsoft acquisition?
Microsoft's recent acquisition of Revolution Analytics could go a long way in solidifying the R language's hold on analytical solutions.
- March 24, 2015
24 Mar'15
Vendors introduce three new SQL Server appliances
If SQL Server appliances are on your radar, you have options, but the price tag is high. Do your homework before buying. Here are the current offerings.
- November 25, 2014
25 Nov'14
SQL Server monitoring tools help DBAs take back nights and weekends
Many DBAs have to work more and more nights and weekends to fulfill zero-downtime demands. But tools for monitoring and managing SQL Server might free up some of that time.
Sponsored News
Using Automation to Solve Data Management Challenges
Sponsored by Symantec - It seems that no organization feels it has enough budget, staff or specialized expertise to establish and maintain a firm, consistent handle on information governance. Data management is becoming more complex in light of rapid and profound changes in technology, regulatory matters, information usage and organizational priorities. See More
Is Your Active Directory Cloud Ready?
Sponsored by Dell - Many companies today are considering a move to the cloud. Organizations may believe that a hosted service, such as Office 365, will be easier and or cheaper to maintain than on-prem email. Also, Microsoft and other industry leaders may have influenced a move. Whatever the reason, moving to the cloud isn't as easy as it appears and results are often mixed if you haven't adequately prepared your Active Directory. See More
Achieving Organizational Competency in Information Governance
Sponsored by Symantec - As organizational data becomes increasingly complex, sophisticated and vital to success, IT departments and business units are becoming more proactive—and collaborative—in developing steps to control data management without restricting user privileges or stifling initiative. See More
Examining the Active Directory's Role in Governance, Risk, and Compliance
Sponsored by Dell - When it comes to governance and compliance, much of the IT staff's effort is often focused on individual systems. Administrators work meticulously to ensure that mail servers, file servers, database servers, and other resources adhere to both internal security standards and regulatory requirements. The one thing that each of these systems has in common however, is its reliance on Active Directory. First introduced in 2000 as a replacement to the Windows NT domain structure, Active Directory was originally designed to manage network resources. Now, Active Directory works as a centralized authentication and access control mechanism, and consequently plays a vital role in the organization's overall security. See More
- November 07, 2014
07 Nov'14
PASS 2014 keynoter previews coming SQL Server advances
Microsoft previewed a cloud database update and highlighted three new analytics applications at PASS 2014, reflecting its idea of using data to 'understand the past, analyze the present and predict the future.
- June 05, 2014
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SQL Server 2014 etches itself in-memory
Microsoft's flagship database is advancing into the largely undiscovered country of in-memory OLTP platforms -- and it's hoping to conquer.
- March 24, 2014
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Finding the right problem for SQL Server 2014's in-memory OLTP
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Following a request from some SQL Server MVPs, Microsoft has announced that SQL Server 2012 SP2 will come out sometime later this year.
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Interactive reports highlight Microsoft SQL Server Reporting Services
Author and Reporting Services expert Brian Larson discusses features of SQL Server Reporting Services in this interview.
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SQL Server 2014 all about big data, in-memory analytics and cloud
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text:
NEW YORK, Aug. 25, 2014 /PRNewswire/ -- Reportlinker.com announces that a new market research report is availabl e in its catalogue:
Vascular Dementias Global Clinical Trials Review, H2, 2014
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- Data on the number of clinical trials conducted in North America, South and Central America, Europe, Middle-East and Africa and Asia-pacific and top five national contribution
|SOURCE Reportlinker
Copyright©2014 PR Newswire.
All rights reserved

subset: commoncrawl


text:
BackgroundVirtua Fighter 4 Evolution is an update to Sega's AM2 division's 2002's Virtua Fighter, now a PS2 Greatest Hit. It contains 2 new fighters, Goh Hinogami and Brad Burns, new arenas, enhanced Graphics, and enhanced play modes.
GameplaySelect your character and opponent, then find a suitable battle arena to duke it out. Each character has their own multiple combos and strategies that can decide who wins and loses the battle. The arena itself also plays an important role by its size. Opponents can easily be thrown out of smaller arenas, and if you get thrown out, you lose. Play against a friend for more spectacular matches.
- All 15 characters (two new) have their own brand of whoop ass with unique attacks, counters, and defense moves.
- Newly optimized graphics for the PlayStation 2 eliminate jaggies and shimmer.
- New Quest Mode - hurl the hurt through several tournaments to become the world champion.
- Twice as many character customizing options as before.
- The aggressive A.I. opponents are modeled after the top players from the arcades of Japan.
Official URLOfficial Site
Recent threads
- Clothes Color Question Jul 20
- vitual Jul 19
- Leifei Aug 7
- Introduce Yourself Jun 26
HullCityTiger33 and 22 others own Virtua Fighter 4: Evolution
izanagi_the_creator and 4 others played Virtua Fighter 4: Evolution
Krazysh0tFighting game VirtuaFighter4Evolution PS2
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IkaryBest (or one of the bests) fighting game, the gameplay is pretty hard first but this game is excellent for fighting tacticians. VirtuaFighter4Evolution PS2
Nov 26, 05 11:34pm
GallantmonXadded 5 new screenshots
Dec 22, 04 9:58pm
Jul 28, 04 5:22pm
Fighting. Evolved.
WOW! All this bang for 20 bucks. You have about 17 characters, including 2 new and...
Mar 18, 04 7:21am
Virtua Fighter 4 Evolution
Its a super bang for 20 bucks.You have 17 characters, 2 new ones.The fighting style is...
DragonFangadded a cheat
Jan 31, 04 1:13pm
DragonFangadded a cheat
Oct 17, 03 6:00pm
Sep 06, 03 10:05am
Evoulution for an Already stellar fighting game
WOW! All this bang for 20 bucks. You have about 17 characters, including 2 new and...
Mecha Gamer X 13added a cheat
Aug 30, 03 4:57am
- Genre: Action Fighting (PS2)
- Perspective(s): Flat side view
- Developer: AM 2
Released North America Mar 13, 2003


text:
Let me preface this by saying I stay at a lot of hotels, but not a lot of Holiday Inns. There was nothing intrinsically wrong with this property - the front desk staff was helpful, the room was clean, the bed was okay. There was nothing great about the property either. Inside it felt a little dark. There's an Outback connected to the property, which is really convenient. We had a small luncheon there for about 20 people and the staff did not adequately set up the room, Fortunately we showed up early to get things squared away and our event took place without issue.
There really is nothing around this hotel - it's not in the best area, but not knowing Laurel I cannot say for sure there are better options, but my gut says there are.
- Official Description (provided by the hotel):
- Welcome to the Holiday Inn Laurel-West hotel a 2007 Intercontinental Hotels Group Renovation Award winner. This full service Laurel, MD hotel is conveniently located at I-95/Rt 198W, exit 33B. Whether you are going to Washington DC or Baltimore, we are centrally located to both locations with easy access. Great amenities corporate guests expect, including complimentary high-speed Internet, business center, and newly refreshed fitness center. Take refreshing dip in our indoor heated pool in our spacious atrium. Begin your day at Atrium Café with a great breakfast, kids 12 and under eat free. Coming 1st quarter 2009 all Platinum and Gold Priority Club members will have access to the 6th floor Executive Club Lounge. A relaxing upscale space, the club level lounge offers complimentary breakfast, d oeuvres and variety of beverage options. End your busy day with a spectacular dinner onsite at Outback Steakhouse. Cheer on local sports teams including the Washington Redskins at FedEx Field, Baltimore Orioles at Camden Yards or the Baltimore Ravens at M&T Bank Stadium. Other local attractions include Laurel horse racing track, Gardens Ice House and Fairlands Athletic Complex. Area business include: UPS, Verizon, Fort Meade, Dreyer s Ice Cream, John Hopkins Applied Physics/Kossiakoff and Lockheed Martin. Local business parks include Sweitzer Lane and Tech Road. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Travelocity, Expedia, IHG, Priceline, Orbitz, Hotels.com, Odigeo, Agoda and Low Cost Holidays so you can book your Holiday Inn Laurel West - Washington DC Area reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Laurel West-i-95/Rt 198w Hotel Laurel
- Laurel Holiday Inn


text:
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Attorneys and law practices have been experimenting with strategies to collect unpaid client fees while limiting the risk of malpractice claims. One approach involves the use of alternative dispute resolution (ADR)...more
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Last week the US Chamber of Commerce, through its Center for Capital Markets Competitiveness, issued a white paper proposing wide-ranging changes to the SEC's enforcement process. Most of the 28 recommendations were...more
"Electronic document creation and/or storage, and electronic communications, have become commonplace in modern life, and discovery of ESI is now a frequent part of almost any litigated matter. Attorneys who handle litigation...more
The Rhode Island Supreme Court "ain't afraid of no ghost."[1] In a long-anticipated, unanimous decision, the Rhode Island Supreme...more
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Judgments; Legislation; and Reports.
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27 March 2015 - Public consultation opens on draft Principles and guidelines for the care and use of non-human primates for scientific...more
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In light of recent changes to the ABA Model Rules of Professional Conduct, what are a lawyer's ethical duties arising from new technology? And what should a lawyer know about technology?
Model Rules' Technology and...more
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The Business Court on Wednesday disqualified a law firm from representing its longtime corporate client in a lawsuit against the corporation's former CEO and Chairman of its Board of Directors....more
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Blawg rules. The California State Bar has issued an opinion outlining the circumstances under which an attorney's blog would be subject to the requirements of the California State Bar Act's Rules of Professional Conduct...more
Disqualifying Celgard's appellate counsel due to a conflict of interest, the U.S. Court of Appeals for the Federal Circuit, in a non-precedential opinion, found that Celgard's preliminary injunction preventing LG Chem from...more
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AngelChicago Model
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Page 1
J. Chem. Sci., Vol. 121, No. 4, July 2009, pp. 397–405. © Indian Academy of Sciences.
*For correspondence
Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes
of phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone
LI-FENG TANa,b,*, XUE-JIAO CHENa, JIAN-LIANG SHENb and XI-LING LIANGa
aCollege of Chemistry, Xiangtan University, Xiangtan 411105, P.R. China
bKey Lab of Environment-friendly Chemistry and Application in Ministry of Education,
Xiangtan University, Xiangtan 411105, P.R. China
e-mail: email@example.com
MS received 25 October 2008; accepted 8 December 2008
Abstract. A novel polypyridyl ligand phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone
(PTBM) and its complexes [Ru(phen)2(PTBM)]2+ (1) (phen = 1,10-phenanthroline) and [Ru(bpy)2
(PTBM)]2+ (2) (bpy = 2,2′-bipyridine) have been synthesized and characterized by elemental analysis,
mass spectroscopy, and 1H NMR. The DNA-binding properties of the two complexes were investigated
by spectroscopic and viscosity measurements. The results indicate that both complexes bind to DNA via
an intercalative mode and the DNA-binding affinity of complex 1 is greater than that of complex 2. When
irradiated at 365 nm, complex 1 was found to be a more-effective DNA-cleaving agent than complex 2.
Keywords. Ruthenium(II) complex; DNA-binding; photocleavage.
1. Introduction
During the last decade, the interaction between tran-
sition metal complexes and DNA has been exten-
sively studied.1–14
Binding studies of small
molecules to DNA are very important in the deve-
lopment of new therapeutic reagents and DNA
molecular probes.15–18 Polypyridyl ruthenium(II)
complexes can bind to DNA in a non-covalent inter-
actions fashion such as electrostatic binding, groove
binding,19 intercalative binding and partial intercala-
tive binding.20 Many useful applications of these
complexes require that the complexes bind to DNA
through an intercalative mode. Therefore, the vast
majority of such studies have been focused on the
interaction of those complexes containing the fully
planar ligands,21–28 and investigations of such com-
plexes with ligands containing substituent as DNA-
binding reagents have been relatively few. In fact,
some of these complexes also exhibit interesting
properties on binding to DNA.29–31 Varying substitu-
tive group or subsistent position in the intercalative
ligand can create some interesting differences in the
space configuration and the electron density distri-
bution of Ru(II) polypyridyl complexes, which will
result in some differences in spectral properties and
the DNA-binding behaviours of the complexes, and
will be helpful to more clearly understand the binding
mechanism of Ru(II) polypyridyl complexes to DNA.
Therefore, further studies using different structural
ligands to evaluate and understand the factors that
determine the DNA-binding mode are necessary.
Thus it is of interest to delineate the effects of the
planarity of the intercalative ligand on interaction
and the binding mode of the complexes to DNA.
We report here the synthesis and characterization
of a new polypyridyl ligand PTBM (PTBM =
yl)-methanone) and its Ru(II) complexes [Ru(phen)2
(PTBM)]2+ (1) (phen = 1,10-phenanthroline) and
[Ru(bpy)2(PTBM)]2+ (2) (bpy = 2,2′-bipyridine)
(scheme 1). The DNA-binding properties of the two
Ru(II) complexes were explored by spectroscopic
methods and viscosity measurements. Their photo-
cleavage behaviours toward pBR 322 were also
investigated. We hope the results to be of value in
further understanding the DNA-binding and effi-
ciency of DNA recognized and cleaved by Ru(II)
complexes, as well as laying the foundation for the
rational design of new photoprobes and photonucle-
ases of DNA.
Page 2
Li-Feng Tan et al
Scheme 1. Syntheses of the ligand PTBM and its Ru complexes 1 and 2.
2. Experimental
2.1 Materials
All materials were commercially available and of
reagent grade, and were used without further purifi-
cation unless otherwise noted. The compounds 1,10-
phenanthroline-5,6-dione,32 cis-[Ru(phen)2Cl2]·2H2O
and cis-[Ru(bpy)2Cl2]·2H2O33
were synthesized
according to the literature methods. Tris–HCl buffer
(5 mM Tris–HCl, 50 mM NaCl, pH 7⋅2, Tris =
Tris(hydroxymethyl)methylamine) solution was
prepared using doubly distilled water. The dialysis
membrane was purchased from Union Carbide Co.
and treated by means of general procedure before
use. CT–DNA was obtained from the Sino-
American Biotechnology Company.
2.2 Synthesis of PTBM
A mixture of (3,4-Diimino-cyclohexa-1,5-dienyl)-
phenyl-methanone (425 mg, 2 mmol), 1,10-
phenanthroline-5,6-dione (420 mg, 2 mmol), and
glacial acetic acid (20 mL) was heated at reflux with
stirring for 2 h. The cooled solution was filtered,
diluted with H2O and neutralized with concentrated
aqueous ammonia. The yellow solid was collected
and purified by column chromatography on alumina
with ethanol–toluene (6 : 1, v/v) as eluent to give the
title compound as amorphous yellow solid. Yield:
660 mg (85%).
Anal. Calc. for C25H14N4O: C, 77⋅71; H, 3⋅65; N,
14⋅50. Found: C, 77⋅53; H, 3⋅82; N, 14⋅40. FAB-
MS: m/z 387⋅6 [M+1].
2.3 Synthesis of [Ru(phen)2(PTBM)](ClO4)2·2H2O
A mixture of cis-[Ru(phen)2(Cl)2]⋅2H2O (114 mg,
0⋅2 mmol), PTBM (77⋅6 mg, 0⋅2 mmol), and ethy-
lene glycol (15 mL) was thoroughly deoxygenated.
The purple mixture was heated for 8 h at 150°C
under argon atmosphere. When the solution finally
turned salmon pink, it was cooled to room tempera-
ture, and an equal volume of saturated aqueous so-
dium perchlorate solution was added under vigorous
stirring. The salmon pink solid was collected and
washed with small amounts of H2O, EtOH, and
Et2O, dried under vacuum, and purified by CC (neu-
tral Alox; MeCN/toluene 1 : 1) to afford 209 mg
(39%) of the title compound.
UV (ε/dm3 mol–1 cm–1, MeCN): 440 (47190), 376
(31050), 281 (238860), 264 (251730),
(400 MHz, DMSO-d6 (dimethyl sulfoxide); d,
doublet; s, singlet; t, triplet; m, multiplet): 9⋅64 (q,
2H), 8⋅81 (t, 4H), 8⋅72 (s, 1H), 8⋅68 (d, 1H), 8⋅48 (d,
1H), 8⋅42 (s, 4H), 8⋅30 (q, 2H), 8⋅23 (q, 2H), 8⋅08
(d, 2H), 7⋅96 (d, 2H), 7⋅91 (q, 2H), 7⋅78–7⋅86 (m,
Page 3
Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes
2H), 7⋅81 (m, 3H), 7⋅69 (t, 4H). ESI–MS (MeCN):
m/z 963⋅4 ([M–ClO4]+), 864⋅1 ([M–2ClO4–H]+),
432⋅3 ([M–2ClO4]2+). Anal. Calc. for C45H34N8
Cl2O11Ru: C, 54⋅34; H, 3⋅14; N, 10⋅35. Found: C,
2.4 Synthesis of [Ru(bpy)2(PTBM)](ClO4)2·2H2O (2)
Prepared analogous to 1, but from cis-
[Ru(bpy)2(Cl)2]⋅2H2O (104 mg, 0⋅2 mol). Yield: 299
mg (44%).
UV (ε/dm3 mol–1 cm–1, MeCN): 442 (38010), 363
(41695), 264 (288110). 1H NMR (400 MHz, DMSO-
d6): 9⋅67 (q, 4H), 8⋅89 (t, 4H), 8⋅73 (s, 1H), 8⋅68
(d, 1H), 8⋅49 (d, 1H), 8⋅29 (t, 2H), 8⋅25 (t, 2H), 8⋅16
(t, 2H), 8⋅07 (t, 2H), 8⋅03 (q, 1H), 7⋅97 (d, 2H), 7⋅85
(d, 2H), 7⋅81 (t, 2H), 7⋅70 (t, 2H), 7⋅62 (t, 2H), 7⋅42
(t, 2H). ESI–MS (MeCN): m/z 920⋅6 ([M–ClO4]+),
820⋅9 ([M–ClO4 H]+), 410⋅6 ([M–2ClO4]2+). Anal.
Calc. for C49H34N8Cl2O11Ru: C, 52⋅22; H, 3⋅28; N,
10⋅83. Found: C, 52⋅32; H, 3⋅12; N, 10⋅85.
2.5 Physical measurements
Microanalyses (C, H and N) were carried out on a
Perkin-Elmer 240Q elemental analyzer. 1H NMR
spectra were recorded on an Avancev-400 spec-
trometer with DMSO-d6 (dimethyl sulfoxide) as the
solvent at room temperature and TMS (tetramethyl-
silane) as the internal standard. UV-Vis (UV-visible)
spectra were recorded on a Perkin-Elmer Lambda-25
spectrophotometer, and emission spectra were recor-
ded on a Perkin-Elmer LS-55 luminescence spectro-
meter at room temperature. Electrospray mass
spectra (ES–MS) were recorded on a LQC system
(Finngan MAT, USA) using CH3CN as the mobile
phase. Circular dichroism (CD) spectra were meas-
ured on a JASCO-J715 spectropolarimeter.
All spectroscopic titrations were carried out in
Tris−HCl buffer at room temperature. A solution of
CT−DNA in the buffer gave a ratio of UV absorb-
ance at 260 and 280 nm of 1⋅8–1⋅9 : 1, indicating
that the DNA was sufficiently free of protein.34 The
DNA concentration per nucleotide was determined
by absorption spectroscopy using the molar absorp-
tion coefficient (6600 M–1 cm–1) at 260 nm.35 Stock
solutions were stored at 4°C and used within 4 days.
Titration experiments were performed by using a
fixed Ru(II) complex concentration, The complex-
DNA solutions were allowed to equilibrate for 5 min
before spectra were recorded.
Viscosity measurements were carried out with an
Ubbelodhe viscometer maintained at a constant tem-
perature of 26⋅0 ± 0⋅1°C in a thermostated bath.
DNA samples of ca. 200-bp average length were
prepared by sonication.36 The flow time was meas-
ured with a digital stopwatch, and each sample was
tested three times to get an average calculated flow
time. Data were presented as (η/η0)1/3 versus binding
ratio,37 where η is the viscosity of DNA in the pre-
sence of complex, η0
being the viscosity of free
For the gel-electrophoresis experiments, super-
coiled pBR-322 DNA (0⋅1 μg) was treated with 1 or
2 in buffer Tris–HCl (50 mM Tris-acetate, 18 mM
NaCl buffer, pH 7⋅2). After pre-incubation of the
solutions in the dark for 1 h, the samples were irra-
diated for 60 min inside the sample chamber of the
spectrofluorimeter (λex = 365 ± 5 nm, slit-width =
5 nm). The samples were then analysed by gel-
electrophoresis for 30 min at 75 V in Trisacetate
buffer containing 1% agarose gel. The gel was
stained with ethidium bromide (EB; 1 μg/mL–1) and
photographed under UV light.
3. Results and discussion
3.1 Synthesis and characterization
An outline of the synthesis of Ru(II) complexes 1
and 2 with the new PTBM ligand are presented in
scheme 1. The ligand PTBM was prepared through
condensation of 1,10-phenanthroline-5,6-dione (3)
with 3,4-diaminobenzophenone (4) on the basis of
the method for dppz ring according to literature
methods.38 Complexes 1 and 2 were then prepared in
yields of 39 and 44%, respectively, by direct reac-
tion of PTBM with cis-[Ru(phen)2Cl2]2H2O and cis-
[Ru(bpy)2Cl2]·2H2O, respectively, in the appropriate
molar ratios, using ethylene glycol as solvent. The
desired Ru(II) complexes were isolated as the corre-
sponding perchlorates, and were purified by column
chromatography. In the ESI-MS spectra of both
complexes 1 and 2, the signals of ([M–ClO4]+), ([M–
2ClO4–H]+), and ([M–2ClO4]2+) were observed, and
the determined molecular weights were consistent
with the expected values.
Both complexes 1 and 2 give well-defined 1H
NMR spectra (figure 1), permitting unambiguous
identification and assessment of purity. The
NMR chemical shifts were assigned by the aid of
1H, 1H–COSY experiments, and by comparison with
Page 4
Li-Feng Tan et al
Figure 1.
1H NMR spectra of complexes 1 (top) and 2 (bottom).
the values of similar compounds.21,39 Due to the
shielding influences of the adjacent PTBM and phen
(or bpy) moieties, H-atoms of complexes 1 and 2
exhibit two distinct sets of signals.
The UV/VIS absorption spectra of 1 and 2
showed well-resolved bands in the range 200–
700 nm, characterized by intense π → π* ligand
transitions in the UV, as well as by metal-to-ligand
charge transfer (MLCT) transition in the VIS. The
broad MLCT absorption bands appear at 440 nm
(for complex 1) and 442 nm (for complex 2), respec-
tively, which are attributed to Ru(dπ) → PTBM (π*)
3.2 Electronic absorption titration
The application of electronic absorption spectros-
copy in DNA-binding studies is one of the most use-
ful techniques.40 Complex binding with DNA
through intercalation usually result in hypochro-
mism and bathchromism, due to the intercalative
mode involving a strong stacking interaction bet-
ween an aromatic chromophore and the base pairs of
DNA. The extent of the hypochromism commonly
parallels the intercalative binding strength. The
absorption spectra of complexes 1 and 2 in the
absence and presence of CT−DNA (at a constant
concentration of complex) are given in figure 2. As
the concentration of DNA is increased, for complex
1, the hypochromism reaches about 25⋅2% at
267 nm with a red shift of 4 nm at a [DNA]/[Ru]
ratio of 5⋅06. The MLCT band at 443 nm shows hy-
pochromism by about 25⋅7% and a red shift of
4 nm under the same conditions. For complex 2, on
addition of DNA, the IL band at about 288 nm ex-
hibit hypochromism of 31⋅2% with a 2 nm red shift
at a [DNA]/[Ru] ratio of 3⋅62. The MLCT band at
443 nm shows hypochromism by about 16⋅9% and
a red shift of 2 nm under the same conditions. Com-
paring the hypochromism of the two complexes with
that of their parent complex [Ru(phen)3]3+ (hy-
pochromism in MLCT band at 445 nm of 12% and
red shift of 2 nm (15), which interacts with DNA
through a semi-intercalation or quasi-intercalation
(19(b)) and considering that the absorption spectrum
of [Ru(bpy)3]2+, a typical electrostatic binding com-
plex, was demonstrated to be unchanged on the
addition of the DNA,18 these spectral characteristics
obviously suggest that both 1 and 2 in our paper
interact with DNA most likely through a mode that
involves a stacking interaction between the tail-end
phenyl chromophore and the base pairs of DNA.
In order to compare quantitatively the binding
strength of the two complexes, the intrinsic binding
constants Kb of the two complexes with DNA were
obtained by monitoring the changes in absorbance at
267 nm for complex 1 and 288 nm for complex 2
with increasing concentration of DNA using the fol-
lowing equation:41
[DNA]/(εa – εf) = [DNA]/(εb – εf) + 1/(Kb (εb – εf)),
wherein [DNA] is the concentration of DNA in base
pairs, εa, εf, and εb are the apparent-, free- and
Page 5
Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes
Figure 2. Absorption spectra of complex 1 (left) and 2 (right) in Tris–HCl buffer upon addition of CT–DNA. Left:
[Ru] = 1 × 105 M, [DNA] = (0–5⋅06) × 10–5 M. Right: [Ru] = 1⋅25 × 105 M, [DNA] = (0–3⋅62) × 10–5 M. Arrow shows
the absorbance changing upon increasing DNA concentrations. Inset: plots of [DNA]/(εa–εf) vs [DNA] for the titration
of DNA with the complex.
bound-metal-complex extinction coefficients res-
pectively. Kb is the equilibrium binding constant (in
M–1) of complex binding to DNA. When plotting
[DNA]/(εa–εf) vs [DNA], Kb is obtained by the ratio
of the slope to the intercept. The intrinsic binding
constants Kb of complexes 1 and 2 were
(1⋅30 ± 0⋅05) × 105 M–1 and (4⋅54 ± 0⋅05) × 104 M–1,
respectively The value is smaller than those of
[Ru(phen)2(dppz)]2+ (>106 M–1),11
(dppz)]2+ (dppz = 7,8-dimethyldipyridophenazine,
8⋅8 × 106 M–1),42 [Ru(phen)2 (phehat)]2+ (phehat =
phenylene, 2⋅5 × 106 M–1).43 However, the value is
comparable to those of some other reported Ru(II)
complexes with extended, planar ligands, [Ru(bpy)2
(dpq)]2+ (dpq = dipyrido[3,2-d:2′,3′-f]quinoxaline)
and [Ru(bpy)2(dpqc)]2+ (dpqc = dipyrido-6,7,8,9-
tetrahydrophenazine) show much low affinity for
(5⋅9 × 104 M–1 and
[Ru(bpy)2(dppz)]2+ due to less -conjugated aromatic
area;44 [Ru(bpy)2(taptp)]2+ (taptp = 4,5,9,18-tetra-
8⋅5 × 104 M–1) than
azaphenanthreno[9,10-b]triphenylene) and [Ru(bpy)2
(atatp)]2+ (atatp = acenaphtheno[1,2-b]-1,4,8,9-tetra-
azatriphenylene) also show smaller DNA affinity
(1⋅7 × 105 M–1 and 7⋅6 × 104 M–1) than [Ru(phen)2
(dppz)]2+, the reason is proposed that the size of the
ligands are too wide.5 This data indicates that the
size and the shape of the intercalated ligand has a
significant effect on the strength of DNA binding,
and the most suitable intercalating ligand leads to
the highest affinity of complexes with DNA. The
different DNA-binding properties of complexes 1
and 2 are due to the ancillary ligand. On going from
bpy to phen, the plane area and hydrophobicity
increased, which led to a greater binding affinity to
3.3 Luminescence titration studies
In organic solvents such as MeCN, MeOH, and
EtOH, complexes 1 and 2 emit luminescence. The
results likely suggest that the more polar the solvent
is, the smaller relative intensities are observed. This
phenomenon has also been found with the Ru(II)
dppz complexes under the similar conditions.45 At
the same time, it is noteworthy that the lumine-
scence of complexes 1 and 2 in these organic
solvents are very sensitive to the presence and con-
centration of water, being almost quenched com-
pletely in the presence of 10% water (v/v). Thus, the
lack of luminescence in water for both complex may
be due to a mechanism similar to that for [Ru(phen)2
In the absence of DNA, complexes 1 and 2 emit
weak luminescence in Tris buffer at room tempera-
ture, with a maximum appearing at 613 and 607 nm,


text:
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Discussion in 'Plumbing and Central Heating' started by Blue70, 22 May 2013.
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text:
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Overall Rating
Out Of
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LMAO<quoted text>
Sorry.... I'm a WOMAN ...
I don't take chit off anyone, especially you uneducated dwIdioTic libTARDS who are politically stupid on an Internet site.
SEE how THAT "works" bub!?!
How old are you??
You have the mental capacity of a 5 year old.
Gonna tell me I have cooties next??


text:
IAC Asks For More Google, Please
IAC has had an agreement with Google for some time now to hand over all search advertising on Ask.com and other IAC sites to the search giant. In 2007, IAC extended the deal, which was worth $3.5 billion at the time, to end in 2012. According to a release issued this morning, IAC and Google has renewed and extended the agreement through March 31, 2016. According to the release, the… Read More
Exclusive: IAC Hatches Hatch Labs, A Technology Sandbox To Incubate Mobile Startups
IAC has made a business out of developing or acquiring mobile applications based on its popular properties. In fact, IAC's mobile apps, which include apps for Match.com, CityGrid, UrbanSpoon, and Dictionary.com, have seen over 40 million downloads as of end of the year 2010. Today, we've learned exclusively that IAC is furthering its mobile strategy by launching Hatch Labs, a… Read More
IAC Elects Former Disney CEO Michael Eisner To Expanded Board
IAC has expanded its board of directors with a thirteenth seat and elected well-known businessman Michael Eisner, who served as chairman and CEO of The Walt Disney Company from 1984 until 2005, to join said board, effective immediately. Prior to his long tenure at Disney, Michael Eisner served as the President of Paramount for eight years after starting his career at ABC. In fact, he was hired… Read More
The Year In Online Video Deals And What To Expect In 2011
With the recent rumor that Google's YouTube unit was looking at acquiring video content company Next New Networks, it's clear that anything can happen in the rapidly growing online video space. While some are shocked to see that Google may cross over and own content, the rumor does sound plausible. Loaded with nearly $25M in venture financing, it's not quite the initial… Read More
Liberty Exits IAC For Evite, Gifts.com And $220M In Cash – Diller Steps Down As CEO
Big move for Liberty Media, IAC and the latter's Barry Diller today. The former has exchanged its entire equity stake in the Internet holding company for a combination of assets and cash in a transaction intended to be tax-free to both companies. Liberty has exchanged approximately 12.8 million shares of IAC stock for all of the capital stock of a wholly-owned subsidiary of IAC that… Read More
The Newsweek Daily Beast Will Make A Monstrous Combination
After a series of on-again, off-again talks, Newsweek is merging with The Daily Beast, the IAC-owned online news site run by Tina Brown. The new joint venture will take the ungainly name of the Newsweek Daily Beast Company. Last August, the Washington Post Company sold Newsweek for $1, plus the assumption of $40 million in debt, to stereo tycoon Sydney Harman. Now Barry Diller is getting… Read More
Exclusive: Bloglines Will Be Resurrected By IAC-Funded MerchantCircle
The saga continues. After informing us in September that the IAC-owned Bloglines was to be shut down permanently, Ask.com (the IAC property that operates Bloglines) has resurrected the troubled RSS feeder, the company tells TechCrunch exclusively. IAC has transferred ownership of the property to an unlikely new patron: MerchantCircle, an online marketing network for small business owners. Read More
IAC Shows Signs Of Life In Third Quarter, Revenues Jump 25 Percent
Barry Diller realizes that his Ask search engine isn't going to gain market share anytime soon, but search can still power growth for IAC if it just keeps up with the growth in the overall search market. IAC released third quarter earnings this morning. Total revenues were up 25 percent to $422 million. Operating income quadrupled to $36 million, and adjusted earnings per share came in… Read More
Compete Top 50: Bing And Ask Rise – MySpace, MapQuest And Flickr Fall
Online analytics company Compete has just published its ranking of the top 50 websites for September 2010, giving some insights into current visitor trends (and not absolute numbers, as the company tends to undercount traffic for most websites). Compete's data compilation shows increasing traffic to Microsoft's search engine Bing (up 11.7 percent for the month and 108.5 percent for… Read More
When Google Wanted To Sell To Excite For Under $1 Million — And They Passed
On stage today at our TechCrunch Disrupt conference in San Francisco, Vinod Khosla, the founder of Khosla Ventures, recalled a story from the days when he backed Excite, one of the original Internet portals. Specifically, he spoke briefly about the time they failed to acquire Google. This story has been circulated for a while, but not many people know about it. Khosla stated it simply: Google… Read More
Barry Diller: Everyone Needs To Stand Up And Protect Net Neutrality — Unleash The FCC!
Today at our TechCrunch Disrupt conference in San Francisco, IAC CEO Barry Diller took the stage for a fireside chat with our own Michael Arrington. They covered a lot of topics, but the first thing Diller keyed in on was the most important: net neutrality. "All of you have to get out there and start arguing for this strongly," Diller emphatically said. He clearly feels very… Read More
Barry Diller: Ask.com Has No Value Inside Of IAC
Many of us may have forgotten that Ask.com is a search engine just like Google and Bing. It seems that IAC's Barry Diller, who owns Ask.com, seems to have no memory of Ask's value as well. Diller sat down with Michael Arrington today at TechCrunch Disrupt, and spoke candidly about the future of Ask.com. Says Diller, "I don't think Ask.com is going to gain search… Read More
Exclusive: IAC Finally Kills Off Bloglines
It's finally happened. Bloglines,the troubled RSS feed reader owned by IAC, will officially be shut down, the company has told TechCrunch exclusively. The site has had a tumultuous history, so it's unsurprising that IAC has finally put the platform out of its misery. Bloglines, which is actually operated by IAC Q&A property Ask.com, will be informing users of the news today… Read More
CollegeHumor Media Launches Videogame Humor Site Dorkly.com
Recently soft-launched by CollegeHumor Media (aka Connected Ventures), the IAC company is today formally introducing the latest addition to its ever-expanding network of funny websites. Meet Dorkly.com, a new videogame humor property that caters to "all gamers, be they nerds, geeks, or even dweebs". That sounds like you, so we thought we'd share. Read More
IAC Buys Into Fitness Social Network DailyBurn
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The Taste Of The iPad. UrbanSpoon Makes Its HD Debut
Before there was even an App Store, I knew there was something to UrbanSpoon. Several million downloads and a sale to IAC later, I can safely say I was right. Now the team behind it is trying to capture the magic all over again with its new free iPad app. On the face of it, UrbanSpoon for the iPad may not seem as useful as it is for the iPhone. After all, most people don't just whip… Read More
Urbanspoon: Half A Billion Shakes And Counting
There's no denying it. People love to shake their iPhones. It's almost as if they want to see how much they can shake it before it breaks. But shaking it is half the fun, especially when apps take advantage of the built-in accelerometer to turn shaking into a feature. One of the earliest apps to make shaking a central element of its interface was Urbanspoon, the restaurant… Read More
My Bloody Valentine: Expedia.com
As you know, today is Valentine's Day. As such, I thought it was the perfect time to write a love sonnet for my new favorite company: Expedia.com. Actually, I'll do the opposite. Seeing as it's a long weekend in the United States (President's Day is on Monday), I decided I was going to set up a little trip to get away with the girl I'm seeing. A few weeks ago, I… Read More
Urbanspoon Expands To The Urban Workforce With A BlackBerry App
In major metropolitan areas, the BlackBerry at lunchtime is a force to be reckoned with. And now it can be a device to help those urbanities actually find a place to eat with the launch of Urbanspoon for BlackBerry. Urbanspoon has been one of the most popular apps for the iPhone since it launched alongside the App Store in the summer of 2008. By blending location data with a fun… Read More
Match.com Acquires People Media For $80M In Cash
Online dating service and IAC property Match.com is getting into the highly-targeted subscription dating game with the acquisition of People Media, which it is taking off the hands of publicly traded PE firm American Capital and a host of other investors for $80 million in cash. The deal includes the purchase of about 27 targeted dating sites with a combined 255,000 paying subscribers… Read More


text:
Jim Arthur, CALSTAR's director of flight operations, said the air ambulance service is very proud of the new aircraft. "The turbine powered aircraft is 'cabin class' and will enhance our ability to provide top quality medical care to our patients," he said.
Tad Henderson, CALSTAR's chief operations officer added, "The addition of the King Air to our fleet helps us to continue our fixed wing transport growth, but even more importantly it helps us to extend our mission of delivering excellent patient care to a larger population of patients that need our service," he said.
Headquartered in McClellan (Sacramento)
Previously owned by a corporation for business travel, the Super King Air underwent a four-month major modification to serve CALSTAR's life saving mission as an air ambulance.
Powered by two Pratt & Whitney PT6A-61 turbine engines, the aircraft boasts a maximum service altitude of 35,000 feet and can cruise at speeds in excess of 330 mph. The aircraft can accommodate two teams of nurses and two patients—either adult or neonatal (infants.) "This airplane's capability safely provides rapid medical transport not only within California, but because of its speed and cruise altitude, western states within 1,000 nautical miles," Arthur said.
As part of the modification, according to Arthur, the cockpit underwent a complete upgrade to one of the most technically advanced avionics systems available. Known as the Garmin G 1000, Arthur says "this advanced package includes weather radar, satellite tracking and telephone and traffic alerting, as well as synthetic vision,"
The aircraft also features a power loading system that takes away the need to physically lift a patient or infant isolette.
From time to time, the aircraft will be utilized by medical centers and their medical crews, in addition to CALSTAR's highly trained nurse/nurse team. "CALSTAR works with area medical centers to provide aircraft and pilot services to a center's specialty medical teams, for example neonatal teams," Arthur said. "CALSTAR supports this effort by providing aircraft and on board medical equipment training to medical center personnel."
"Because this aircraft carries the same advanced life saving equipment that can be found in a medical center's emergency room, our patients can expect the best in medical care," Arthur said.
The airplane is expected to be ready for final release for use by September 10.


text:
The COMPLETE Perversity - 2.0 Test
Their result for The COMPLETE Perversity - 2.0 Test ...
You scored 28 percent perverse!
Their Analysis (Vertical line = Average)
They scored 28% on variable 1, higher than 54% of your peers.
All possible test results
You've been sheltered, chosen the straight and narrow or you're lying (in which case, add an extra 25%). You might have a few quarks or random experiences but in the perverse department you pale in c... Read more
Mildly Corrupt
You have goals you just havn't reached yet. Your level of perversity is moderate however high enough to make some people raise their eyebrows. Read more
Clever, crafty and busy are your hands... and other such body parts. You have explored and experimented and might have a few sexual hobbies but nothing that puts you too far out of the range of most ... Read more
Your experiences and life style have begun to compromise the moral standards of society. Ohh what fun! You have enough perversity to shame your parents and blush the cheeks of your friends and co-wo... Read more
You are an animal in your sexual desires and persuits. Your experiences are raw, numerous and frequent. Be sure to warn your subjects as they fall in your path. Read more
You live a life that makes you a God or Goddess in the realm of sexual abundance and deviation! As a man, other men toast to your prowess. As a women, other women despise your presence and chances a... Read more
Nefarious Perversity
You are feared by all who know your sexual reputation yet your victims seem to fall for you anyway. Your life style (and thats what it is at this level) may be borderline illegal and congress has use... Read more
Somewhere the devil, satan, hades or some lord of the underworld is saying "damn, what a resume`!". Chances are you have broken over a dozen different laws, punishable by death or dismemberment in 20... Read more
Recent Results
ZCWH19 / m / Straight
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http://lowkickmma.com/author/DaddyLongStrokes DaddyLongStrokes
I picked Overeem vs Werdum. Because Werdum will do things differently the second time around. One of the hype trains will become derailed, and I believe it would be Werdum's.
http://lowkickmma.com/author/willc09 willc09
gotta be Stout and Fisher for me, just simply becasue they go to war everytime and put on a fan freindly show. Stout with the win this time, those hands are vicious!
http://lowkickmma.com/author/DR3W DR3W
Lesnar vs Mir. One a lot of bad blood that is always entertaining. Two mir has built a lot of muscle and strength. three they both have improved and it should be a much closer fight.
http://lowkickmma.com/author/HunterB HunterB
Griffin vs Ortiz for me. With Tito's recent performance it makes me wonder if hes caught a second wind late in his career. Beating Forrest would put him back in the top 10 mix… something i never thought i would even contemplate again.
http://lowkickmma.com/author/Ninja Ninja
Gotta go with Cruz vs Faber….that 2nd fight was too sick n it was so close love to see them fight again also Barnett vs Nog III would b sick too
http://lowkickmma.com/author/scrappymcgee scrappymcgee
Shogun vs Machida because the technique is beautiful and they are so close in ranking
http://lowkickmma.com/author/JoeySantosus Joey Santosus
What I find most interesting about this poll thus far is that Lesnar vs. Mir is leading… Which is odd because when Dana White revealed his intentions to schedule the rubber match earlier this year, it was met with backlash and resistance. Fans literally began tweeting him hate messages and telling him no one wants to see it. So it never materialized.
http://lowkickmma.com/author/dray12 dray12
I honestly find none of those interesting. Cruz Faber, Griffin Ortiz are the only two that are fitting, but still I don't rlly want to see those fights right now.
http://lowkickmma.com/author/IChokePeople IChokePeople
That is my second choice. I don't think it would be close at all. I think Mir would do the same thing to him that Cain and Carwin did. Mir has always had superior stand up and he has been working on his wrestling along with hypertrophy and strength. All it takes with Lesner is a few good shots and he starts doing cartwheels. A bit of take down defence and Mir can land those shots.
http://lowkickmma.com/author/IChokePeople IChokePeople
That's my choice. That first fight was razor close. The second ended too quickly to really tell too much aside from seeing Shogun realize that an overhand right was a good tool to use against Machida and seeing Machida use a very out of character strategy. I would love to see how III would go. I think I would have to go with Machida by decision or later round KO.
http://lowkickmma.com/author/IChokePeople IChokePeople
We live in a fickle, fickle world man.


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"The whole issue is confected and those claiming racism under every rock need to wake up to themselves."
"How long until the first numpty claims a link to anthropogenic global warming?"
"The present system of certification by doctors is clearly not working. A doctor may have a long and..."
"It is interesting that most of those on this thread wearing the white halos and brandishing their usual..."
"Distraction? State of Origin has been, and still is, the pinnacle of rugby league in Australia. To my..."
"Oh Boy. To think the electorate ditched Newman because he was trying to fix the Labor mess - well he..."
"Marriage is a union between a man and a woman. It is a special thing, one that has served civilisation..."
"Since moving to the Coast from Brisbane about 12 years ago, my wife and I quickly learned to accept..."
"No evidence at all that this is anything other than a natural occurrence. The Chicken Littles can..."
"This is all much ado about nothing. The USC has a huge productivity issue; compared to other..."


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Less is More in Website Design
twenty4 has a strong philosphy with approach to all online experiences we create – Less is More.
It's happened to all of us: we visit a website and get bombarded with countless tabs, categories, feature articles, rotating pictures, music and pop ups, only to panic and hit the exit button faster than you can say sensory overload.
A great website, as far as we're concerned is one that is as intuitive as possible – meaning people who visit your website can easily navigate their way through it without confusion. Basically – it's all about clean, minimal design that ultimately allows for easy viewing and interaction.
These factors are particularly important for those operating in the e-commerce sector, to remove any barriers or distractions to the key focus of finding the desired product and making a purchase. It's always nice when your customers can work their way through your site and actually make it to the check out. True?
Liken it to a supermarket – imagine if your products were all over the floor, instead of neatly stacked on shelves. Or rather than goods being arranged in categories the tomatoes were kept in the same shelf-less space as the chemical cleaning products. It's confusing, and likely to result in fewer purchases. Just like a supermarket, a website should be designed to make life as easy for the consumer as possible, and for those in e-commerce, it should be designed in a fashion that ultimately encourages purchases.
Do not however mistake the words clean and minimal, for boring and dull. Our philosophy is that good design, you don't actually notice it. Your website design should be aesthetically pleasing, and representative of your brands personality. Take for example the site we built for Grown, an organic alchemist that produces high quality beauty products. Their philosophy is simple: grown, not manufactured; thus their website design needed to reflect this. (www.grown.com)
"Less is more" – it's an approach to web design that is fast becoming a global movement; one that you should be part of, whoever you digital agency partner is.
More Recent Articles
How to Raise Over 2 Million Dollars Online
We're still in awe at the stunning success that the Freeze MND campaign saw during it's campaign run from May to June this year. With a final tally of more …READ BLOG
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While it might not be top of mind, website security demands a big conversation — not only for web developers, but for anyone who has or maintains a website or…READ BLOG
The Internet of Things…and why it's broken
Facebook, Uber, Silvertop, Gmail, Apple Mail, Messages, Spotify, Instagram, Reddit, Twitter, Facebook Messenger, Snapchat, Yik Yak. I could go on, but I'm sure you know where I'm going with this. …READ BLOG


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Complication of metastasis, the process in which cells detach from the primary tumor to form new distant tumor sites, is the primary reason why patients die from cancer. Most of our knowledge of tissue homeostasis, tumor initiation, progression and metastasis, and chemotherapy resistance is derived from techniques that draw a static picture of these highly dynamic processes. To study the dynamic aspects of these processes, the van Rheenen group develops state-of-the-art imaging techniques to visualize and study individual cells in real-time in living animals, referred to as intravital microscopy. By these experiments we hope to indetify new drug targets that combined with current clinical approaches may lead to new therapies.
About the research
About the group
"Kijken naar kanker" - Spying on cancer!
This movie by the Netherlands Genomics Initiative, the Netherlands Cancer Institute, the University Medical Center Utrecht and the Hubrecht Institute, visualizes malicious cancer cells during their journey
Selected recent key publications
Zomer A, Maynard C, Verweij FJ, Kamermans A, Schäfer R, Beerling E, Schiffelers RM, de Wit E, Berenguer J, Ellenbroek SIJ, Wurdinger T, Pegtel DM, van Rheenen J, (2015), In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior. Cell, 161(5):1046–1057 Zomer_et_al_extended pdf
Ellenbroek SI, van Rheenen J. (2014) Imaging hallmarks of cancer in living mice. Nature Reviews Cancer, 14(6): 406-18
Ritsma L*, Ellenbroek SI*, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J, (2014) Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature, 507(7492): 362-5
Ritsma L, Vrisekoop N, van Rheenen (2013) In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique. Nat Commun., 4:2366
Ritsma, L.*, Steller, E.J.A.*, Beerling, E., Loomans, C.J.M., Zomer, A., Gerlach, C., Vrisekoop, N., Seinstra, D., van Gurp, L., Schäfer, R., Raats, D.A., de Graaff, A. Schumacher, T.N., de Koning, E.J.P. Borel Rinkes, I.H., Kranenburg, O. van Rheenen, J. (2012) Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis. Sci Transl Med 4, 158ra145.
Jalink K, van Rheenen, J (2010) Nano-imaging of membrane topography affects interpretations in cell biology. Nat. Meth. 7:486.
Snippert HJ, van der Vlier LG, Sato T, van Es JH, van der Born M, Kroen-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. (2010) Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells, Cell, 143(1): 134-144.
Publication list


text: Elena Santarelli And Melissa Satta Leggy On Italian TV Show Domenique Cinque Nov 15, 2011 Elena Santarelli Place your ad here Loading... Like the article? Please share on your social network. :) Facebook Google+ Twitter Reddit LinkedIn Pinterest You may also like ... Elena Santarelli – Infiore Lingerie Collection Autumn/Winter 2013 – 2014 Elena Santarelli Sexy Long Legs On Italian TV Show Kalispera Elena Santarelli Modelling Agogoa Bikini During Milan Fashion Week


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Team One Tickets is a privately owned agency that buys and resells 2 Chainz tickets on the secondary market. We are not Ticketmaster, LiveNation, StubHub or the official 2 Chainz box office nor are we affiliated with 2 Chainz or any professional sporting organization, performer, or venue. Our ticket prices reflect the cost of obtaining premium seating and are usually sold above "face value".


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With 1.7 million freelancers, we'll match you with the perfect talent.
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We are seeking a professional and high quality developer to develop our new app for iPhone, iPad and Android.
As this is the first app we will be designing I am seeking a professional who can work with us, highlight the things we need to know and ensure we include all the features we need to make this an excellent app.
App to be based on 'Magrack' template and needs Push Notifcations. Needs to be published in the App Store and others.
Experience developing a magazine app would be preferrable but not necessary.
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Gerai Bawah PokokAugust 10, 2014Indian • Petaling Jaya, Malaysia
Nasi Kandar from 11am..
Tom yam is good. Dishes are simple yet satisfying.
Pretty slippery at some places. Lifeguards a bit blur. Retail staff are good. Park not too bad.
A good experience for the kids..
Jalapeno poppers.. a must try
There is a foldie bike shop called Van's Urban Bicycle at Setia Avenue above the Nissan showroom
Nasi Lemak Ayam not too bad..
As of 7th July 2013, Van's Urban Bicycle have moved from 3 Two Square to No 26, Jalan SS1/22. Same row as the Mobil/Esso petrol station.
Grand Opening & Tern test ride day on May 19th 2013!
Opening in May 2013! The foldable bicycle specialists are coming to rock Setia Alam!
Try out the K3K Benta Kaya kopitiam at block C! Value for money!
Live BPL matches on the big screen on weekends
bad service.. Can't get a table even after making a booking earlier.


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As Of Counsel to the firm, Mr. Altchiler will strengthen Grimes & Battersby, LLC's core intellectual property practice area, specifically as it relates to intellectual property enforcement and anti-counterfeiting. Mr. Altchiler's substantial courtroom experience will be an invaluable addition to the firm's already powerful litigation team. Mr. Altchiler will also lead the firm's white collar criminal defense and corporate investigations practice.
Chuck Grimes, Managing Partner of Grimes & Battersby, LLC, commented: "This is an exciting addition to Grimes & Battersby. Having Mr. Altchiler on board enables us to enhance and expand the value-added services we provide to our clients."
Grimes & Battersby, LLC is a preeminent law firm representing clients worldwide. The firm is renowned in all areas of intellectual property, including all aspects of intellectual property protection, intellectual property exploitation and intellectual property management. Grimes & Battersby, LLC represents prominent businesses, individuals and celebrities in entertainment licensing, product licensing, character licensing and franchising matters, and in connection with trademark, copyright, patent and trade dress enforcement. The firm's attorneys are leading members of the legal profession and are recognized authorities in all aspects of intellectual property, licensing and litigation.
Mr. Altchiler is the founder and owner of Altchiler LLC. A former prosecutor in New York City, Mr. Altchiler represents businesses and individuals in defending complex white collar matters, managing criminal investigations and conducting internal corporate investigations. Mr. Altchiler frequently participates in high-profile cases and the defense of prominent businesses and individuals, utilizing his extensive experience in crisis management and public relations for the benefit of clients. Mr. Altchiler has been a featured legal commentator appearing on major news outlets for many years. He has also been an adjunct law professor at Pace University School of Law for over a decade.
For more information about Grimes & Battersby, LLC visit www.gandb.com.


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Gauchos Perform in Cross Country Championships
The UCSB men's cross country team takes first in the Big West Championships, while the women finish in third.
The UCSB men's cross country team takes first in the Big West Championships, while the women finish in third.
The UCSB men's and women's cross country teams travel to Riverside to compete in the Big West Tournament.
Several UCSB runners competed at the NCAA Regionals this weekend.
UCSB sends 14 runners to NCAA Regionals in Sacramento
UCSB performed well at the Big West Championships this weekend.
At the NCAA West Regional in Eugene, Oregon on Saturday, UCSB cross country ran well against the best teams from the west. The women's team finished fifth out of 31 teams, behind Washington, Oregon, Stanford, Arizona, and tied with Cal, beating the likes of USF, Cal Poly, and UCLA.
This weekend, UCSB cross country travels to Eugene, Oregon to compete in the NCAA West Regionals on Saturday. The top two teams will automatically earn a trip to Indiana with a spot in the NCAA National Championship on Nov. 22.
The UCSB women's cross country team won its second consecutive conference title at the 2010 Big West Championship on Saturday Oct. 30, holding off rival Cal Poly 35-37. Senior Amanda Moreno set a course and Big West record of 19:57.0, becoming the first woman to break the 20-minute mark at the conference meet.


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Uncorked: Marques de Alfamen Garnacha Syrah
Let's take a trip to Spain, shall we? Well, sort of.
This blend by Marques de Alfamen combines one of the most widely planted grapes in the world, Garnacha, which unequivocally originated in Spain, with Syrah, a grape of mysterious origins. Although DNA testing has concluded that Syrah originated in Southeastern France, the grape shares many of the same characteristics that make Garnacha such a stout, complex grape variety. Even if they're not from the same place geographically, Garnacha and Syrah might as well be brothers from another mother.
Both varieties feature dark fruit, high tannins and acidity and are regularly linked to savory flavors of chocolate and tobacco. Honestly, because this wine is just about an even split between the two, you'll have trouble pinpointing which grape you're tasting, so don't even bother. Just know that this wine is stout and keeps on giving off flavor long after you've consumed it. The color is vibrant, deep purple, almost as if the squid ink black of syrah has clouded the brighter Granacha. On the nose, you'll get black pepper, dried tart blackberry, cola and light vanilla. These are warning signs that you're in for a bold experience and this blend does not disappoint. You'll get a bold astringency and acidity right up front, but there is a push of tobacco, ginger and oaky smoke that follow along with subtle dark fruit. You'll be left with a herbaceous, cut grass flavor that lingers, but aerate this wine or allow it to open up for 20 to 30 minutes and you get something else entirely. That very "green" sensation gives way to much brighter, jammy black cherry that makes this wine more drinkable. Approach that first glass with caution and be patient; there's a great, balanced wine here a few minutes after it's opened, but if you want some intensity, you can enjoy this right out of the bottle.
High alcohol Granacha actually works as a solvent to capsaicin, which is what lends heat to spicy foods. Naturally, any wine heavy on Granacha works well with spicy foods, no matter where they come from. However, the herbaceous quality of the wine would work great alongside some spiced black beans, sautéed red onion and jalapeños or habaneros. Throw some roasted, pulled pork in the mix to provide a sweet aspect to this unsweet wine and you'll have a dish that fills in a lot of what this wine leaves blank on your palate.
Wine: Marques de Alfamen Garnacha Syrah
Vintage: 2012
Varieties: 60 percent Garnacha, 40 percent Syrah
Alcohol: 13.5 percent ABV
Region: Alfamen, Spain
Cost: $10 to $15
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Category: "Diane Sawyer"
Bruce Jenner to confirm transition in Diane Sawyer interview; his mom is proud
Did Katie Couric really accuse Diane Sawyer of giving beejs for interviews?
Was Diane Sawyer wasted during ABC's election night coverage?
Julia Roberts poured on the charm with Diane Sawyer's husband, and Diane is pissed


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"Paper Products in Lincoln Park!" Elizabeth Grace Paperie & Gifts Tip by BeatChick
Elizabeth Grace Paperie & Gifts, Chicago: 1 reviews and 3 photos
Whenever I see the word "paperie" in a title, I am almost guaranteed to shop there! So here's a lovely little paperie in Lincoln Park in its lovely little building surrounded by other lovely places to shop (Seventy-Five Shoes, Molly's Cupcakes) all along Clark Street.
What to buy: TokyoMilk Perfume - purchased their heavenly Gin & Rosewater here.
Also picked up Buckeyballs for my science geek son.
Also to be found: Stationery, colorful custom wedding invitations, beautiful baby announcements
What to pay: $30 for the perfume, $35 for the Buckeyballs
Address: 2438 Clark St, Chicago, IL 60614
Directions: Lincoln Park area on Clark St, south of W Arlington Pl & north of W Fullerton Pkwy
othercontact: email@example.com
Phone: 773.477.9830
Theme: Stationery
Website: http://www.elizabeth-grace.com/
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$700—$750 1 bed 1436 S. Irving Street, Denver CO, 80219
from $700 1 bed
1436 S. Irving Street, Mar Lee, Denver, 80219
Commute to Downtown Englewood
from $700
1 bed
The rent at 1436 S. Irving Street ranges from $700 for a one bedroom to a $750 one bedroom. Apartments in this building are about as expensive as the Mar Lee average.
This apartment is in the Mar Lee neighborhood in Denver. Nearby parks include Garfield Lake Park, Sanderson Gulch Park and Sanderson Gulch Park.
1436 S. Irving Street has a Walk Score of 73 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
Parkwood Plaza offers one bedroom floor plans that are conveniently located in Denver, Colorado. Come visit us today!
Owner/manager tools | Report bad listing | From apartmentsearch.com
Most errands can be accomplished on foot.
A few nearby public transportation options.
Flat as a pancake, excellent bike lanes.
About your score
Explore how far you can travel by car, bus, bike and foot from 1436 S. Irving Street.
1436 S. Irving Street has some transit which means a few nearby public transportation options. Car sharing is available from RelayRides.
Bus lines:
14 West Florida Avenue
0.1 mi
36L Fort Logan Limited
0.2 mi
30L South Federal Limited
0.2 mi
30 South Federal Blvd
0.2 mi
31 Federal Blvd
0.2 mi
Car shares:
1436 S. Irving Street compared to all of Denver.
Average crime area.
Lower crime area.
How do you feel walking near 1436 S. Irving Street?
Thanks for your feedback!
1436 S. Irving Street is in the Mar Lee neighborhood. Mar Lee is the 36th most walkable neighborhood in Denver with a neighborhood Walk Score of 60.
Moving to Denver from another city? View our moving to Denver guide.


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Discover a selection of top forums engined keywords on the internet. Come to share your passion on forums engined keywords and meet other fans of engined keywords. Then, why don't you create your own forum of engined keywords ?
Porsche 924 944 968 928 and other classic car forum
porsche, classic, forum, owners, front, #engined, club, tipec, pcgb
Free forum : Local Ad Link is a brand new online advertising platform that allows businesses to finally dominate even the most competitive and expensive keywords


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Adoptions & Events
First Annual — Atlanta Lab Rescue 5K Fun Run & Festival!
The Atlanta Lab Rescue 5k Fun Run and Festival will take off from Jim Miller Park in Marietta at 9:00 am on November 21st. This will be our inaugural race and families, kids and dogs are welcome. After race festivities will include games, food, free stuff and a "Lab Lap," 1K Fun Run! Even if […]Read More »
Welcoming Your Shelter Dog Into Their New Home
Here is a great and useful article by Debbie Jacobs….Also….ALR volunteers are always happy to help provide information for bringing home your new dog and making it a successful transition!! Moving is among the most stressful experiences for a social animal. You know that life for your newly adopted dog has just taken a turn for […]Read More »
6 Ways Dogs Help Ease Depression Symptoms
Here is a great article authored by Therese Borchard . 6 Ways Dogs Help Ease Depression Symptoms My husband and I had to put down our Labrador-Chow mix this morning. He did exactly what his sister did nine months ago: went out to our backyard on a cold and rainy night and just stood there, with his […]Read More »
NEXT Adoption Day – October 25th from 1-3 at Southern Tails Academy!!!
The next Adoption Day will be October 25th fom 1-3 at Southern Tails Academy in Marietta. Southern Tails is one of our boarding/training partners and we had such a good time last month that they invited us back every month. It's a large and very relaxed area and the perfect place to spend time […]Read More »


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2013 Rte. 66 Shelter Tour
2013 Rte. 66 Shelter Tour
Snuggle Buddies for Man's Best Friend
Introducing ProZip
Spring Dog Toys from West Paw Design
Handcrafted Adorableness Made In The USA
West Paw Design's Most Eco-Friendly Dog Toys Are Here!
(Bozeman, MT - February, 2013) West Paw Design just got a whole lot greener by adding two new black Zogoflex® durable dog toys! Introducing black Tux® and Jive™. Inspired by the success of the best-selling black Hurley®, West Paw Design created a collection of near zero waste chew dog toys to satisfy ball-loving labs and treat-hungry hounds.
Meet two wild and tough girls: Dakota & Havoc. These two beautiful Rhodesian Ridgbacks are in their doggie teenage years (both are "2 human-years" old) and love to play. Luckily for these playful dogs, their human mom discovered the guaranteed tough Zogoflex dog toys:
Otis is a 5 year old Pit/Boxer mix that is tough on his dog toys. His favorite game is hide and go seek with his toys... and the super-durable Hurley dog toys are perfect!
Molly is a cute little "rascall" of a dog who's from Colville, Washington. Molly loves her Bumper Bed and Big Sky Blanket. Her human Mom especially loves that both the blanket and dog bed are washable... it seems that being neat and tidy are not Molly's biggest strengths!
A story of a rescue dog that didn't understand what "play" was... until their new family showed her:
Kiko is a 2 and a half year old Australian Shepherd / American Staffordshire Terrier mix that loves to dock dive. Like many super-active dogs, Kiko is hard on her dog toys.


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A few weeks ago the girls from hostel came to The Mountain Fund house in Kathmandu and entertained our volunteers with a dance show.
The next day we had the chance to see the performance they were rehearsing for in person when we attended the family day festival at Orchid Garden.
Enjoy the photos from both the practice dance at our house and the on-stage performance the following day. It's really amazing how these children, all from Kathmandu's poorest families can put on such a great dance show.
We have had some setbacks the past few months, I am sorry to report. The landlord from the first flat we rented to house the girls asked us to leave, claiming that 9 girls make too much noise. The current landlord is threatening to toss us out as well. In Nepal, people do not want to rent for children's homes and finding a cooperative landlord is an ongoing challenge. Perhaps one day we can purchase a home and be free of this constant threat that hangs over the girls.
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
If you donate to this project or have donated to this project, you will get an e-mail when this project posts a report. You can also subscribe for reports via e-mail without donating or by subscribing to this project's RSS feed.
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If you look for a room to rent in Bangkok, check Facebook: FindYourRoomInBangkok
There is no 5th and 13th floor but 12A why??!!
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Make sure your information is up to date. Plus use our free tools to find new customers.
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Oldsmobile Alero Questions Any type
- Newest
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Headlights Won't Turn Off On 2000 Alero
Turn the car off, headlights don't shut off. Even after waiting, never shut off. Have to disconnect battery to get them to turn off.
I Have A 1999 Alero! The Temperature Gauge Keeps Bouncing Back And Forth Bu...
How Long Do Alero Last
We r looking at a 2004 Olds Alero that had 186,000 on it. How many miles do these cars usually go as far as mileage?
I Have A 2.3l, 2001 Oldsmobile Alero, I Think I Need To Change The Fuel Pum...
Diagnostics Say. Missfire
I Have A 2003 Oldsmobile Alero I Will Crank Fine But Will Not Start Without...
2001 Olds Alero. Put In A New Fuel Pump, Filter And Relay And Get No Fuel ...
My son 's car just quit in store parking lot. I figured out it was not getting fuel and put in a new relay, pump and filter. Still no fuel to fuel rail. Also discovered that his key doesn't alway...
Wil A 2001 Oldsmobile Alero Keep Runing If I Disconnect The Batterry
Car Want Start Back Up
I had a radiator But on my car And the fog lights in the headlights Was taken out And was not put back in or plug back in And I drove the car about 4 miles And it cut off on me And wouldn't start ...
How To Change The Spark Plugs On A 2004 Alero 2.2
I Have A 1999 Alero And It Won't Start. I Have Recently Put Spark Plugs And...
bad fuel pump or fuel injector or maybe a bad fuel filter. What do you suggest that I check first. I must tell you that I am in a wheel chair because I have an amputated left leg above the knee. C...
The Radio Doesn't Work In My 2002 Alero, What Could Be Wrong
I recently purchased a 2002 Olds Alero GL. They replaced the alternator. Now my radio won't work at all. I also don't have an access code.
Car Troubles
I have a 2000 alero that won't start most of the time ..problems are....leaks coolant on the ground real bad ...cranks then after a while it fires up ...but now it barely cranks and have to put th...
My Bleeder Is Not Sputtering Any Water Out Somebody Said That It Could Be M...
My car has been running hot for six mos im finally in a position to fix now i thonk i have a blown gasket i put in stop leak in my radiator for my heads but the bleeder wont work its blowing out s...
Olds Alero Where Is The Switch To Activate The Trunk Interior Light
my trunk convenience light remains on when the trunk is closed , draining the battery. where is the switch located?
My Dash Has Gone Out, Any Ideas On How I Could Possibly Fix Problem Myself?...
My Car Starts, But As Soon As I Put It In Gear, It Stops. Anyone Have Any S...
Where To Add Freon To 2003 Alero Oldsmobile With A 3.4 V6 Engine.
I want to add freon and not sure where. I see a place between the radiator fans and engine but want to be sure. Thanks!
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Hotels Near Kelowna Airport
Displaying 1 Hotels in Kelowna
More IHG Airport Hotels near Kelowna (Kelowna ) Airport
Holiday Inn Express Kelowna Conference Centre
The hotel features a 4500 sqft conference centre, 6 spacious function rooms that can accommodate a variety of meeting configurations. We can make your meeting, conference, wedding or retreat exceptional event for you and your guests. Bring the entire family and enjoy our indoor pool and 2 waterslides. We are conveniently located near many attractions, shopping centre and recreation activities.
4.3 /5 (319 reviews)
2429 Highway 97 North, Kelowna, BC V1X4J2, Canada
Hotel Reservations : 1 877 424 2449 | Hotel Front Desk : 1-250-7630500


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Latest Content
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The Crimson is one of three Division I teams that reached the NCAA Tournament and also received the award.
Men's Basketball Schedule Features Trips to Kansas, Hawaii
The Harvard men's basketball schedule for the upcoming season is out, and it features marquee matchups against Kansas, Providence, and potentially New Mexico.
Temi Fagbenle To Continue Basketball Career at USC
She may have hung up her Crimson jersey, but college basketball has not seen the last of Temi Fagbenle '15.
Male Athlete of the Year, Runner-Up: Saunders Wills Crimson to Ivy Title
Senior wing Wesley Saunders averaged 16.6 points, 6.1 rebounds, and 4.3 assists per game this season, capping his career with a 26-point performance against North Carolina in the NCAA tournament.
The Place of Club Sports at Harvard
From aikikai to archery, water polo to wushu, Harvard club sports run the gamut of interests, experience, and athletic skill levels found across campus.
BRIEF: Mosca, Manchester Perform for Men's Swimming at NCAA Championships
The men's swimming and diving team's season came to an end this weekend as two final competitors participated in the NCAA Championships in Iowa.
BRIEF: Mosca Moves on to NCAA Championships
In the Zone A Championships, Mosca competed in both the three-meter and one-meter events. He placed well enough to move on to the NCAA Championships in both events.
Women's Basketball Ends Regular Season With Victory Over Brown
The Crimson capped off a four-game win streak in its final game of the season Saturday night as Harvard defeated Brown by a score of 76-69.
Athlete of the Week: McDonnell Shines Brightest In Final Home Game
One could say that without co-captain Erin McDonnell, the Harvard women's basketball team could be walking away from this past weekend with very different results.
Women's Basketball Takes Down Cornell, Sweeps Season Series
After returning from a four-game road trip in which the team went 1-3, Harvard defeated the Big Red by a score of 60-54 on Friday night at Lavietes Pavilion
Men's Swimming and Diving Takes Second at Ivy League Championships
Senior Mike Mosca's sweep in the one and three meter dives helped the Crimson place second at the Ivy League Championships.
Late Triple Helps Women's Basketball Sink Columbia
A late three from senior Erin McDonnell helped the Crimson put away Columbia in an 82-81 victory on Senior Night.
Women's Basketball Splits Pair of Road Contests
While a basketball game is 40 minutes long, the Harvard women's basketball team have set the tempo for the outcome of its games in the first few.
Women's Basketball Falls To Brown
For the second consecutive game, the Harvard women's basketball game came down to the last minute, and for the second time, the Crimson was on the losing end of a neck-and-neck battle with an Ivy League foe.
Athlete of the Week: Seniors Lead Men's Swimming and Diving to HYP Victory
The class of 2015 is going out with a splash. The Harvard men's swim and dive team (9-0, 7-0 Ivy) finished off the dual meet season with a sweep of Yale (7-2, 4-2) and Princeton (7-3, 5-1) in the annual HYP meet this weekend.