text:
Searching for a new happy medium
Whoa whoa whoa – can you say post-vacation letdown? Emo alert on that last post. Sorry folks, welcome to my world. It's a little weird.
Anyhoo, it is definitely time to get out of my own head. There are many many things to do around here. So far, the plans for next year have gone from deciding that we will not be doing a family vacation because of my Camino to HEY LET'S DO EVERYTHING IN 2016.
Where we were: September 2016: Camino
Where we are now: December 2015: Move to a house
March 2016: 5 Day Cruise for Lolly's 40th birthday
June 2016: Spend a week in St George Island with the fam
September/October 2016: Dad and I go to Spain
There may be just a little stress involved there. Maybe. I mean, it's great, and I'm thankful. But it's overwhelming, especially since I'm only working part time now. Correction: VERY part time. I'd love to get something else, but then it interferes with real life too much and just ends up being a hassle for very little $$ return. Repeat: I'm thankful. It's not a terrible problem to have, and I know that. But I'm starting to feel a little useless, and I don't like that.
I read a little article yesterday (you can find it here) that basically explained the worst possible life circumstance for each Myers-Briggs personality type. I'm an ENFP, which is no surprise, and here's what mine said:
ENFP – Every minute of the rest of your life has been scheduled for you – and it's a long series of arbitrary, solitary tasks.
Note to self: Don't let this happen. I hate ruts and every emotion that goes with them. Trouble is, I find myself in them pretty easily. Why would I be drawn to the situation that would hurt me the most? Lord, I've asked myself that question before.
But I digress. Again.
The point here is that I'm going to have to get outside more, meet new people, and stop being at home so much. I can't expect The Universe to give me opportunities if I don't go out into it.
Is that the point? Hell, I don't know. Thank goodness I'm the only one who reads this thing.
Oh, Dawes…
You speak to my spoiled, everbroken heart.
I got my pack! It's an Osprey Sirrus 24 and my first official piece of Camino gear!
Dad and I went up to Tallahassee to conquer a few hills, and ended up at Trail & Ski. Imagine that. :)
The guy there was SO helpful. We were really just there to poke around and look at prices and things, but when I put the pack on, Dad basically said, "Happy Early Birthday!" and I ended up going home with what will soon be my best friend. (I hope.) Here's a pic of her:
Now, she's small. But Nadine says I can do it, so I believe her. It will be a challenge. The pack itself weighs 2.3 lbs, which leaves me about 8 lbs of stuff to put in it. Then water and food. The rule of thumb is that you should be carrying about 10% of your body weight, which puts me at 12 pounds, give or take a little. It's a challenge, that, if completed, will make my feet and back mucho happy.
Can I just go? Now?
Changing things up, blogwise.
Hey! I'm messing with my theme today, so everything's going to be all jacked up for a bit. :)
I've apparently lost my old header, which is sad sad sad…but Kate is 16 now so I should probably do a better job of keeping up with the times. We'll see what I can come up with.
Anyhoo, hang in there with me while I play with this thing, and if you have any suggestions, feel free to jump right in with them.
It's ok to remember. Spin on, mad world. <3
I thought of you, and where you'd gone… and the world spins madly on.
Tiny little update
Walking my arse off. Maybe literally.
Cruise in 23 days.
Camino in 469 days.
I'm happy. That's all.
What Kind Of Man- Florence + The Machine
You can do the thing!
Welp, my busy-ness means I am not here very often. Stopping in to let all 28 followers of mine know that this little dude and I believe in you. :)
Self talk
Oh boy.
I have a LOT going on right now. Is there such a thing as a goal-junkie? I've gone from never ever setting goals, for fear of never reaching them, to wanting a set, measurable goal for everything I do. Yes, this is good, but as a person who gets overwhelmed easily, sometimes I fear that I'm setting myself up for failure. The key to all of this is going to be organization – once again, not normally one of my strengths. Hello, 2015 Challenge.
From past experience in things like Weight Watchers and onthejob happenings, I know that if I have a measurable goal and keep track of progress, I WILL accomplish it. Now that I'm starting a new job from home, getting fit, learning Spanish, returning to the Catholic church, and in the meantime trying to be an exceptional mom and spouse(ish), I realize how important it is to measure daily, weekly, monthly, and have set benchmarks to know if I'm keeping up. This is where my passion planner comes in. Now, because I was late to the game, I'm not getting it til February so I just have to Hold On through January so that I don't lose motivation.
This is likely a real bore of a post to anyone who isn't me, so congratulations if you actually read it. Sometimes you just need to put it out there, ya know? (I know.)


text:
A cliff-top location in the whale-watching capital of Hermanus means sensational ocean views from this elegant, clean-lined guesthouse.
A stunning golf course & magical spa are the highlights of this grand hotel, set between Cape Town & the whale-watching town of Hermanus.
Go whale watching & shark-cage diving from this welcoming, clifftop guesthouse, set overlooking Walker Bay just two hours from Cape Town.
Whale watching & gourmet cuisine are on offer at this elegant boutique hotel, set on the cliffs of Hermanus just 1.5hrs from Cape Town.
A cliff-top location in Hermanus plus ocean-facing rooms means this service-oriented boutique hotel is ideal for whale-spotting.
A cliff-top retreat just an hour from Cape Town, luxurious Birkenhead Villa has magnificent whale-watching views over Walker Bay.
Nature lovers will love Mosaic, a tucked-away riverside lodge located near whale-watching capital Hermanus, two hours from Cape Town.
Stay at the heart of whale-watching country at this superior seaside guesthouse, situated near Hermanus & just over an hour from Cape Town.
Whale watching in season is the big drawcard for this chic Hermanus beach house, set overlooking the ocean just 1.5 hrs from Cape Town.
Nature-lovers & romantics alike will relish the fabulous setting & ambience of this eco-lodge, two hours from Cape Town on the Whale Coast.

subset: commoncrawl


text:
Athletic Scholarships
With the grueling practice schedule and frequent games that comprise the life of a student athlete, figuring out how to pay for school is probably the last thing you want to worry about. Unfortunately, though, the problem of how to find money for college can be even more challenging for student athletes. Federal financial aid can help cover your tuition, but you probably want to avoid student loans, since earning a steady income from athletics can be a difficult task. Working your way through college while playing a sport can be nearly impossible, unless you've discovered a way to attain a college degree without actually devoting any time to coursework. And unfortunately, not everyone who plays sports is lucky enough to land a starting position on the team of a top university or to receive the generous scholarship award that comes with such an honor.
However, this doesn't mean that student athletes need to give up on the prospect of winning scholarships to do what they love to do. Student athlete scholarships are available from a wide variety of sources, ranging from the university you choose to attend to numerous private funds. Both national and local scholarships for student athletes can be found, funded by anyone from the local Dollars for Scholars to multinational corporations. Additionally, you don't have to be on your college's official team to win a student athlete scholarship. Several scholarship opportunities are given to students who have played sports in high school, or who otherwise show a commitment to athletics.
University Scholarships for Student Athletes
The most common student athlete scholarships are awards given to players by colleges and universities. These may cover all or part of tuition and can even include a stipend, since being a student athlete is often a full-time job. Students hoping to be recruited by coaches shouldn't just sit back and hope their dream school finds them. Rather, you should be proactive in conducting a college search to find schools you'd like to attend and teams you'd like to play on, then contact coaches yourself to see if they might be interested in getting you to play on their team and possibly landing you a student athlete scholarship.
Other Student Athlete Scholarships
For students who are looking for other sources of scholarship money instead of or in addition to university athletic scholarships, private scholarship funds do exist. Below is a list of a few popular student athlete scholarships available in our database. For a more comprehensive list, as well as information on other college scholarships for which you may qualify based on your background and interests, conduct a free college scholarship search and go for scholarship gold.
Last Edited: August 2015
Scholarships by Type
- Anti-bullying Scholarships
- Academic Scholarships and Merit Scholarships
- Acting Scholarships
- Agnostic/Atheist Scholarships
- Athletic Scholarships
- Aviation Scholarships
- Bible Scholarships
- Cancer Scholarships
- Celebrity Scholarships
- College Scholarships and Grants for Single Mothers
- Community Service Scholarships
- Corporate Scholarships
- Dance Scholarships
- Disability Scholarships
- Distance Learning Scholarships
- Easy Scholarships
- Essay Scholarships
- Federal Scholarships
- First in Family Scholarships
- Full Tuition Scholarships
- Green Scholarships
- International Student/Study Abroad Scholarships
- Largest Dollar Amount Scholarships
- Last Dollar Scholarship
- Legacy Scholarships
- Local Scholarships
- Military Scholarships
- Minority Scholarships
- Non-Academic College Scholarships: Scholarships Aren't Just for "A Students" Anymore
- Online Scholarships
- Prestigious Scholarships
- Religious Scholarships
- Scholarship Contests & Sweepstakes
- Scholarship Essay Contests
- Scholarship Poetry Contests
- Scholarships for Adult Students
- Scholarships for Average Students
- Scholarships for Gay or Lesbian Students
- Scholarships for Men
- Scholarships for Moms
- Scholarships for Returning Students
- Scholarships for Summer
- Scholarships for Undocumented Students
- Scholarships for Women
- September 11th Scholarships
- Study Abroad Scholarships
- Technology Scholarships
- Transfer Scholarships
- University Scholarships
- Unusual Scholarships
- Veteran Scholarships
- Video Contest Scholarships
- Weird Scholarships
- Women's College Scholarships, Grants & Fellowships
- Writing Scholarships
College Scholarships
- Featured Scholarships
- LGBTQ Scholarships
- Scholarship Application Strategies
- Scholarship Information
- Scholarships by Grade Level
- Scholarships by Major
- Scholarships by State
- Scholarships by Type
- Scholarships Trending Now
- Scholarships.com Scholarships
- Sports Scholarships
- Success Stories
- The Common Scholarship Application
Financial Aid
Latest College & Financial Aid News
Video Gaming: The Up-And-Coming Collegiate Sport
October 8, 2015
by Susan DutcaThis past Saturday at 9 a.m., players arrived at the University of Cincinnati's basketball arena for a two-day tournament hosted by the UC's League of...Legends? Yes: The university now considers League of Legends an official club sport, just like soccer or rugby. With 14,000 people watching the tournament online, the event became one of the largest collegiate e-sports events with participants [...]
Should Political Correctness Trump Personal Opinion?
October 6, 2015
by Susan DutcaLast week, a Mount Holyoke College professor allegedly went around his class trying to guess what racial slurs minority students might have been called in their lifetime. Students claimed the exercise was a form of racial discrimination. In this day and age, we are more politically correct than ever before. College students now think twice before raising their hands to offer an opinion on [...]
How to Not Lose It with Group Projects
October 5, 2015
by Erica LewisOh, yes, group projects. When it comes to group projects, you either love 'em or hate 'em. There's really no in-between. So how do you keep your cool when you can't stand your partners or the project itself? Divide the work evenly. Don't let one person do all the work and then have the other names attached to the project. Although the load may be carried more heavily by one [...]


text:
Originally posted on HoopStuff | Last updated 1/17/13
The Raptors are having an incredibly disappointing season and look as though they will miss the playoffs, once again. They were expected to fight for the 8th seed in the playoffs after a solid draft, starting the new season healthy, adding point guard Kyle Lowry and getting last year's top five pick, center Jonas Valanciunas over from Europe. However, horrible defense, injuries and general poor play, currently have them in 12th place in the East and 6 games out of the playoffs. Injuries have been a factor, as Andre Bargnani, Valanciunas and Lowry have all missed significant playing time. Lowry was also demoted after the inspiring play of Jose Calderon in his absence, however Lowry is the better player and should be starting. All is not bad, as they have a lot of solid young players and will get better by simple development. They have been reportedly interested in trades and they have the pieces to add almost any player they desire. With tradable assets in promising rookie, Terrence ...
NBA News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Publishers
Company Info
Follow Yardbarker
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
An explanation of how WRI conducts analysis of climate and energy proposals before the US Congress.
Insights: WRI's Blog
Insights offers WRI experts' timely analysis and commentary on crucial issues at the nexus of environment and human development.
For cross-post requests and other inquiries, please contact Online Editor Sarah Parsons.
Leading Topics
Updates on the latest country pledges -- will they be enough?
Despite projections, many financial analysts ignore the risks and opportunities associated with environmental trends. ENVEST seeks to change this.
Today's announcement from the White House suggests that significant emissions cuts could save money--along with the environment.
A wrap-up of key messages from EMBARQ's Transforming Transportation 2010.
A new project will help identify and measure the water-related risks facing companies and their investors, and lead to better environmental decisions.
Water scarcity, water pollution and water competition are various risks that could significantly harm a company's operations. Even so, they are often overlooked by investors, financial analysts and businesses. Piet Klop, Senior Fellow in WRI's Markets and Enterprise program, answers questions about why water matters to companies.
I was surprised to learn from Nordhaus and Shellenberger's recent piece in Foreign Policy that WRI has magical powers.
Over the past several years, a number of analysts have attempted to estimate the costs of adaptation for the developing world.
WRI President Jonathan Lash previews the key environmental issues to watch in 2010.
Here is a summary of a civil society consultation WRI had with the World Bank Group's (WBG) Independent Evaluation Group (IEG), on the IEG's review of the effectiveness of the WBG environmental and social safeguards.


text:
Gisele Is Releasing a $700 Coffee-Table Book
About — what else? — Gisele.By Véronique Hyland
About — what else? — Gisele.By Véronique Hyland
Perfect for space-bound Lady Gaga.By Allison P Davis
Averages $9,800 per baby, compared to $2,600 in Britain.By Kat Stoeffel
Even rich philanthropists can't quite afford the neighborhood.By Adam Martin
And "related paraphernalia."By Ally Betker
It cost upwards of $17,000.By Ally Betker
Model Kel Markey thinks so. And she was there.By Alex Rees
A similar version is for sale on Net-a-Porter for only $29,000!By Ally Betker
Reasonable, yes/no?By Alex Rees
It doesn't come free with your soy latte.By Alex Rees
Clear off the No. 1 spot on your holiday wish list.By Alex Rees


text:
FORT RILEY — Geary County Unified School District 475 and Fort Riley are moving forward with the construction of a replacement elementary school on post. The organizations are figuring out the next steps for the project, currently scheduled to begin construction in March or April of this
The novel avian H7N9 influenza virus has caused more than 130 human infections with 43 deaths in China. New research, conducted under the supervision of Kansas State University's Juergen Richt, is showing promise in helping to fight this deadly virus. "Emergence of a novel drug-resistant
Genevieve L. "Genny" Matthews, 87, of Manhattan, died Wednesday at the Meadowlark Hills Sloan House. The family provided some of the following information. She was born on Feb. 23, 1926, in Great Bend. She was the daughter of Fred and Ruby (Parker) McClure. Genny was raised in
Gov. Sam Brownback touched on a lot of topics Wednesday during his State of the State Address before a joint session of the Kansas Legislature. Perhaps of particular interest in Manhattan was his assertion that "Our universities are critical." He talked of "strategic investments" already
Deb Patterson is just trying to focus on today and then move on to tomorrow. It's really just one step at a time for the Kansas State women's basketball coach, as she prepares her team for another big-time test this Saturday at home
Oh what a game. A marvelous effort that not only produced a victory on the basketball court but also very well may have saved Kansas State's status as a major university in the state and nation. In 1964! Hyperbole? No sir. No way. The 50-year
For those who need a football fix during this off-season lull, the Flint Hills Discovery Center has just what the doctor ordered. Or maybe that should be "what the coach ordered." In the spirit of the center's mission, "Football" is an interactive exhibit that
City commissioners insist they don't want existing homes to become "floodplain slums" because of proposed new building regulations. During Tuesday's work session, commissioners agreed that one of the regulations under discussion does more harm than good. Senior city planner Chad Bunger explained that
All the snow cover left on the ground from early winter snowfall actually protects crops from the recent frigid temperatures. K-State agronomy professor Jim Shroyer said that snow cover decreases the risk of damage to winter wheat in the extreme conditions the area has seen
The Kansas Legislature convened this week in a session that will likely be dominated by school finance and the upcoming election season. School finance, a perennial issue, will be of particular interest in the coming weeks as lawmakers and school districts await the Kansas Supreme
You can download and print:
Terms of Service | Privacy Policy | The Manhattan Mercury, 318 North 5th Street, Manhattan, Kansas, 66502 | Copyright 2012
Reproduction of any kind is prohibited without written consent.


text:
Incontinence & Overactive Bladder Health Center
Total Incontinence - Topic Overview
Total incontinence is the continuous and total loss of urinary control.
One cause is neurogenic bladder. This is a neurological problem that prevents the bladder from emptying as it should. Spinal cord injuries, multiple sclerosis, and other disorders that affect nerve function can also lead to total incontinence. In women it can be caused by a vesicovaginal fistula. This is an abnormal connection between the urinary tract and the vagina.
Recommended Related to Urinary Incontinence/OAB
You're toiling on the treadmill, Stairmaster, or recumbent bicycle -- and the accident happens: a little urinary incontinence. Small leaks can occur whether you're a teen or a woman in her 20s and upward. Often incontinence starts after childbirth or as the result of athletic injuries. Some men have incontinence problems after prostate surgery. "Unfortunately, people [with incontinence] stop doing things they enjoy, like high-impact aerobics," says Roger Dmochowski, MD, a urologist and director...
Read the At the Gym With Incontinence article > >
Total incontinence is usually treated by using a thin tube, called a catheter. You use it to empty the bladder regularly. This is called intermittent self-catheterization.
Absorbent products such as pads or disposable underwear are usually used when other methods of treating incontinence have failed or can't be used. These methods don't treat the incontinence. But they may make it possible to manage the problem.
In this article
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise


text:
Geology Companies in Thailand
Category: Soil & Groundwater ×
Subcategory: Geology ×
Industry: Mining ×
Location: Asia & Middle East ×
Location: Thailand ×
The Best Project Material Co.,LTD
based in Tai'an, CHINA
The Best Project Material Co., Ltd is dedicated in geosynthetics R&D, production, sales and installation services of processional manufacturers. Main products including geomembrane, geotextile, geosynthetic clay liners, geogrid, geocell and so on. The products approved by the ISO9001, ISO14001, BV certificates and passed the test of SGS, SONCAP, SASO etc. Products are ...
Willowstick Technologies LLC
based in Draper, UTAH (USA)
Willowstick is a leading provider of innovative subsurface water mapping services. The Willowstick Method is proprietary and provides an enhanced understanding of subsurface water characteristics that were previously unattainable. This increased knowledge and insight allow you to efficiently and cost-effectively plan remediation and monitoring strategies for your ...
Geomorph Instruments
based in Piraeus, GREECE
GM Radars (Geomorph Instruments) is a leading company in non-destructive testing and geophysical services in Europe, Middle East, Africa and Asia. GM Radars owns advanced geophysical and NDT equipment in order to provide high-quality services around the globe. We have offices in London (UK) and Athens (Greece). We also sell geophysical, NDT, safety and military equipment ...
Aquatech International Corporation
based in Canonsburg, PENNSYLVANIA (USA)
Aquatech International Corporation is an Original Equipment Manufacturer of industrial water and wastewater treatment systems and is located in Canonsburg, Pennsylvania in the USA. With offices across the US, Canada, India, the Middle East and China and with installations in over 60 countries worldwide, Aquatech is poised to be your preferred water and wastewater ...
based in Geneva, SWITZERLAND
SGS is the world's leading inspection, testing, verification and certification company. From testing for micropollutants to ensuring compliance with new greenhouse gas emissions regulations, SGS can help your business optimize its relationship with the environment. SGS is accredited to certify US, EU, Australian and many other local environmental standards including JI, ...
Advanced Geosciences, Inc.
based in Austin, TEXAS (USA)
Advanced Geosciences, Inc (AGI) is a manufacturer of electrical imaging systems and software and is the leading developer and manufacturer focused on electrical resistivity, IP and SP. AGI instruments and software are delivered to all continents.
RockWare, Inc.
based in Golden, COLORADO (USA)
RockWare, Inc., incorporated in 1983, creates and markets affordable geo-scientific computer applications. In-house developed products include RockWorks, RockWorks GIS Link, and LogPlot. RockWare also markets and distributes third party products through its catalog and web site. Industries include oil & gas, aggregates, industrial minerals, uranium, coal bed gas ...
C Tech Development Corporation
based in Henderson, NEVADA (USA)
C Tech Development Corporation offers Environmental Visualization System (EVS) and Mining Visualization System (MVS) software. C Tech unites state-of-the art analysis and visualization tools into an extremely powerful software system developed to meet the needs of geologists, geochemists, engineers and modelers. The graphical user interface is integrated with modular ...
Sistema Azud, S.A.
based in Alcantarilla, SPAIN
Azud Group is among the world leaders in filtration, giving solutions to the optimization of the quality of water in industrial, agricultural and urban applications. SISTEMA AZUD is a group of companies made up by more than 20 firms. Sensitive to the problems of water, the main objective of AZUD is the development of technologies and products that allow the efficient use ...
ZZ Resistivity Imaging Pty. Ltd.
based in Adelaide, AUSTRALIA
ZZ is a South Australia based geophysical company, specialising in the development of resistivity instruments and inversion techniques. We manufacture world-leading 61-channel resistivity data acquisition systems and 2.5D inversion software.


text:
Check Us Out on Facebook
See more postcard images like those featured above along with other historic images of Carthage, click here.
Since 1988, the Powers Museum has been serving Carthage, Missouri, as a local history museum with a variety of programming and rotating exhibits.
Powers Museum is OPEN through November 1 on Tues.-Sat. 10:30 am to 4:30 pm.
Special Sunday Opening for quilt show on October 18 - 1-4 pm.
"Finer Things Tea" on Oct. 12 has sold out. For those with tickets, program starts at 1:30 pm and doors will be open at 1:00 pm.
October 18 Special display on local DAR Chapter & Missouri Day video presented throughout afternoon featuring historic Arrow Rock MO.
November 1 Veterans Day Program featuring Shannon Kelly who will be presenting on the World War I Centennial & Missouri's participation, 2 pm (doors open at 1:30 pm), free admission
November 1 is also quilt display take down day, so exhibit gallery will be in transition and no new display will be put up as this is the last day our our public season of 2015.
November 13 1:30 pm Local/Regional History Research Mini-Workshop featuring 4 speakers including Erin Smithers, State Historical Society of Missouri, Springfield Research Center at MSU. Free admission, but reservations suggestion. Target audience: individual researchers & area historical/cultural heritage organization volunteers/staff/board members.
November 14 Annual Santa Surplus & Rummage Sale Fundraiser, 10am to 3 pm, SATURDAY ONLY this year. Watch for more information.
Museum Research Access Policy: Use of any research materials stored on site requires advance appointment and payment of research fee. Only a few items housed in the meeting room are available for free walk-in, self-directed use during public hours (if there is no special program scheduled for multi-purpose meeting room/reference library room on day of person's unscheduled visit).
Also, on-site personnel will not be able to assist walk-ins with use of accessible materials except to answer a few basic questions and point out suggested resources on library shelves. Researchers who need staff assistance for use of available resources in meeting room/reference library area beyond ten minutes should make a research donation of $5.00 in the museum's donation box.
Anyone desiring access to vertical files, former exhibit materials, archival collections and/or access to collection artifacts -- all stored in non-public areas and requiring advance preparation to present to researchers and insure a work space is available for your use -- must make advance appointments at least 2-3 weeks in advance of visit and pay a research fee ($15.00) at the time of appointment.
For more information and/or to make appointment, contact museum by phone 417-237-0456. All appointments subject to staff/volunteer availability.
Follow us on Facebook and Twitter for updates and other postings including historic images of Carthage, Missouri ("Powers Museum of Carthage" for Facebook & "Powersmuseum" for Twitter).
Powers Museum Website Search Email anytime if you have questions about website, scheduled programs or our collections. NOTE: Search feature does not work on Internet Explorer but does on other browser platforms.
Copyright © Powers Museum1617 West Oak • P.O. Box 593 • Carthage, MO 64836e-mail: email@example.com | phone: 417-237-0456All Web site design, content and solutions are property of Powers Museum


text: Chemistry Community In 'Community' Community Back to 'School of Chemistry' Welcome to your Chemistry Community: a network for alumni, students, faculty and friends from the School of Chemistry and part of the College of Engineering and Physical Sciences Community. Stay in touch Whether a student, recent graduate or seasoned alumnus, let us know where you are and what you are doing. Contact us EPS Alumni Office College of Engineering and Physical Sciences Gisbert Kapp University of Birmingham B15 2TT United Kingdom email@example.com Keep connected Connect with us today to keep up to date with the latest news, find old friends or join us at one of our events. Events You are welcome to attend our seminars that take place regularly during term time. Keep an eye on our events page for details of forthcoming talks. Community news Women in Science and Engineering Society - July 2015 DescriptionIt's been a busy year for the Women in Science and Engineering (WISE) Society, as they work to provide as many events and opportunities as possible to members across the College of Engineering and Physical Sciences to integrate, form networks and to help inspire the next generation of female scientists and engineers. The committee tell us more. University of Birmingham host 2015 Fuel Cell & Hydrogen Technical Conference DescriptionThe University of Birmingham hosted the 2015 Fuel Cell & Hydrogen Technical Conference at the Millennium Point in Birmingham on Tuesday 19 - Thursday 21 May 2015. The conference brought together experts in fuel cell and hydrogen research and application from across Europe to discuss the technical developments and trends within the science and technology industry. Birmingham chemists lead on safer, more effective pharmaceuticals DescriptionProfessor Nigel Simpkins, the University of Birmingham's Haworth Chair of Chemistry, has had a paper published in the Royal Society of Chemistry journal Chemical Science, entitled 'Highly enantioselective access to diketopiperazines via cinchona alkaloid catalysed Michael additions'. The paper, co-authored with Alejandro Cabanillas, Christopher D Davies and Louise Male, is the result of a collaborative PhD studentship with AstraZeneca, which is continuing the collaboration with both a new studentship and a postdoctoral researcher who will work at the AstraZeneca site near Manchester. Displaying 4 to 6 of 35 Previous 1 2 3 4 5 … Next Get Involved There are many ways you can get involved in the School, your relationship with us doesn't end with graduation. Alumni profiles Samantha Brown DescriptionMarketing Manager, InnospecBSc Chemistry (1997), PhD Synthetic Organic Chemistry (2001) Barry Hill DescriptionDirector, Micro Research Limited, PhD Chemistry (1983) John Guy DescriptionEducation Consultant and Senior Advisor, University of Cambridge International Examinations, BSc (Class I) 1971, Chemistry ; PhD 1974 (Chemistry) Alan Barber DescriptionFormer Category Issues Manager, Unilever, PhD Chemistry (1976), BSc Chemistry (1972) Displaying 1 to 4 of 6 Previous 1 2 Next


text:
Resolution: standard / high
Figure 7.
Integrated bisulfite DNA methylation analysis platform consisting of the BISMA primary sequencing data analysis software and the BDPC compilation and clustering programs. The result HTML files from BISMA for unique sequences can be further analyzed and displayed with the BDPC compilation software, which will provide an overview table. This table can be used for further result presentations with the BDPC clustering software.
Rohde et al. BMC Bioinformatics 2010 11:230 doi:10.1186/1471-2105-11-230


text:
Finally something special for tea lovers! Or for that matter, anyone who demands a great tasting dessert. These green tea cupcakes with cream cheese frosting will have you coming back for a second cup. A second cupcake that is, because these beauties are absolutely delicious. Even if you aren't a tea lover you're going to be impressed with the gentle, mellow taste of the green tea that infuses these light and oh-so-fluffy cupcakes that anyone would be proud to serve.
Source: Mrs. B's Kitchen


text:
Witnesses testify man is caring
Friends say accused dad is laid-back
Defense testimony in the trial of Brent Allen Benefield, 31, continued Thursday in 30th District Court.
Subscribe to the Times Record News
Ready to subscribe to the Times Record News? Choose between a Premium or Digital subscription below.
Need Help? Call us at 1-877-710-6181.
Monday-Friday: 5:30am-8pm / Saturday: 6am-1pm / Sunday: 6am-1pm


text:
"He makes it really easy on you as a coach because he has tremendous football instincts," Michigan tight ends coach Jay Harbaugh said. "Things come really naturally to him. He doesn't have to see things too many times. He has a good sense for how things should look and feel, and he's a tough, physical guy."
Wallpaper Season - Utah
Greetings again, my fellow Wolverines! Last week, I was able to drop the first official wallpaper of the season in my vintage schedule wallpaper based on a schedule card from 1969. This week, I'm happy to bring you the wallpaper for our first opponent of the season, the Utah Utes.
In preparing to do this wallpaper, I did a good amount of research on the Ute people, for whom the team is named. The Ute people are also the namesake of the state of Utah, itself. The word "Ute," in the native tongue of the Ute people, Shoshonean, means "land of the sun" or " the high place." The Ute people were a highly-artistic people, making all sorts of beaded jewelry for use in battle and for trade. The Ute were also some of the earliest adopters of the horse in America (reports state as early as 1580). They were fierce warriors and with the addition of horses, became excellent big game hunters, as well. They were also highly spiritual, and are credited as being the first documented (by approx. 200 years) peoples to make use of a process called "mechanoluminescence" in their ceremonies. It's said that they would use clear quartz crystals inside of translucent buffalo hide rattles. When rattled, the friction and mechanical stress of the crystals impacting each other would create a light that would be visible through the hide rattles. They believed this was evidence that the spirits were being called to their ceremonies.
I had a lot of fun researching the Ute people and it reminded me of the excellent time I had when doing research for the CMU wallpaper. I loved learning about the Chippewa and the Ute were the same experience. That being said, I hope that we stomp them on the football field. Respect gained for their history or not, I want them crying in defeat.
The image I used for the wallpaper below is of an actual Ute Tipi (or Teepee) on file at the Library of Congress. I hope I did a job that is both respectful and artistically-sound. Let me know! As always, I appreciate constructive criticism and/or suggestions for future works. Have a wonderful day and GO BLUE!
Desktop (16:9) 1920x1080
Mobile (iPhone 5) 640x1136
- JonValk
Wallpaper Season - Vintage Schedule Stylings
Well, it's that time again, ladies and gentlemen - it's wallpaper season. For this season's schedule wallpaper, I went with a design based on (ok, copied from) a vintage schedule card from 1969.
I like how it turned out, but I do wish I could find an image of Harbaugh in the exact same profile as Bo from the '69 card. If you know of one (I looked around to no avail), I would be very grateful to the person who pointed me to it. I ended up choosing a picture that embodies how I hope to see Jim on the sidelines during our games - enjoying some Michigan domination. Anyway, I hope you enjoy this wallpaper. As always, I welcome constructive criticism and/or suggestions for new wallpapers. Let me know what you think. GO BLUE!
EDIT: Fixed the font with a font more like what is in the original per numerous suggestions. Thanks for the input, it looks a lot better, guys.
EDIT 2: Added mobile (iPhone 5) variation.
Desktop (16:9) 1920x1080
Mobile Version (iPhone 5) 640x1136:
- JonValk
Wallpaper Season - Butt, Jake Butt (UPDATED)
Ok, so, just for fun, I'm doing a series of wallpapers based on movie posters. If you recall, last year I turned Jake Ryan into Captain America. This year I'm starting out with a remake of the Skyfall poster and featuring Jake Butt. If for no other reason than it's fun to say "Butt, Jake Butt." Anyway, I like how it turned out, but I'd love some constructive criticism and suggestions for movie posters to recreate with Michigan favorites. Enjoy!
- JonValk
Wallpaper Season - The Genius of Jim
Ok, so this was more an exercise in creating a magazine spread than me designing a wallpaper, but it occurred to me that many of you are just as crazy obsessed with Harbaugh's presence at Michigan and may enjoy it. This was a concept piece I did this week for a fictional magazine article about Jim. I did it because I'm working on building up a portfolio of various graphic design templates in order to possibly land some freelance stuff. I hope you all enjoy it. It has been sized to fit a standard HD 16:9 screen because that's what I run. As always, constructive criticism and suggestions are welcome.
- JonValk
Wallpaper Season - The Harbaugh (Godfather Theme)
Took some time and did another unhealthy and obsessive Harbaugh wallpaper. This time I noticed that one of his press-conference photos had him giving a relatively Godfather-like stare, so I ran with it. I hope you enjoy another off-season wallpaper effort. As always, constructive criticism and/or suggestions are welcome. Go Blue!
- JonValk
Back to the Future - MGoBlog Edition
Ok, so since this is Back to the Future year, I figured I'd do a BTTF-themed work. I wanted to have some fun and not put WAAYYY too much time into this, but I did do my homework. Most of the expressions are near-perfect and I put a few Easter Eggs in the layout. I hope you enjoy it. This was mainly for fun, so I'm less worried about constructive criticism for this piece.
Bonus content, t-shirt idea art.
Enjoy! Go Blue!
- JonValk


text:
Put Your Head on My Shoulder
- Episode Description
When Fry and Amy decide they have a lot in common and begin an office romance just before Valentine's Day, Bender is inspired to start his own dating service, which many apply to, including Leela. Fry just decides to break up with Amy when he is injured in a car crash, and his body is so badly damaged that his head is temporarily transferred to Amy's body. Amy manages to find another date for Valentine's Day, so Fry applies to Bender's service.moreless
- Cast & Crew
David Herman
Katey Sagal
Billy West
Lauren Tom
Tress MacNeille
- Fan Reviews (11)
Cool episode!
A good Romantic Episode
Delightfully twisted...
hilarious epsisode
Fry and Amy become really close.
- Trivia & Quotes
Quotes (58)
Amy : It worked! They totally think we're making out! Fry : Yea! (He and Amy begin juggling)...Hey, why aren't we making out? Amy : I don't know.
Bender: Yep, everything worked out great thanks to good old Bender. Leela: Come on! It's not like you intentionally set us up with bad dates so we'd spend Valentine's Day together. Bender: Didn't I, Leela? Didn't I? Leela: No! You didn't! You just corralled a bunch of stiffs at the bus station and pocketed our money! Bender: True. But in the end, isn't that what Valentine's Day is really all about? Leela: Yeah. Fry: I guess so.
Farnsworth: I still don't understand why you wouldn't let me graft a laser cannon onto your chest. To crush those who disobey you... But I guess we're just two different people.
Zoidberg: There you are, good as new. Except for your dorsal fin. I'm afraid I couldn't find it after the crash. Fry: Can I live without it? Zoidberg: If you call that living.
Gary: I'm a banking industry regulator. Leela: Really? Y'know, I heard that banking industry regulations are really very simple. Gary: Oh, no, that's not true. You see, modern banking regulations are a product of five different regulatory traditions. Six if you wanna get technical. Leela: Oh, I do.
Notes (1)
Bender's sign says "Discreet and Discrete." Discreet: Respecting privacy / maintaining silence about something of a delicate nature. Discrete: Not joined to another / separate.
Trivia (10)
When Petunia tells Fry she can't kiss him because she lost her teeth pulling a stump it's completely obvious she has a mouth full of teeth!
Can labels seen in the planet express closet: Emergency Beans, and Condensed Milt
Opening theme promotion: NOT BASED ON THE NOVEL BY JAMES FENIMORE COOPER Cooper is most famous for his novel "Last of the Mohicans."
Zoidberg's human anatomy chart is upside-down.
Larry (Mom's #2 son) and Leela's ex-boss are in the line outside the Dating Service, along with Hattie, the cat lady.
Allusions (8)
The song playing at the beginning of Fry and Amy's trip to Europa is "Moons of Jupiter" by Scruffy the Cat.
Alfa Romeo: The car Amy buys is a "Beta Romeo". This is a reference to the Italian automobile manufacturer Alfa Romeo (founded in 1910). 'Alfa' is pronounced the same way as the first letter of the Greek alphabet, 'Alpha' and 'Beta' is the second letter of the Greek alphabet.
AAA: Amy belongs to the Septuple-A (The Austro-Afro-Antarctico-Amerasian Auto Association) which is like present-day Triple-A (The American Auto Association.)
LOOK HARD: In the supply cupboard, there are two binders/books/boxes labelled 'P' and 'NP' in the bottom left of the picture. Quick reference to P and NP problems.
2010: (the sequel to 2001) The big black monolith near Europa (with an "Out of Order" sign) is a reference to the sequel to 2001, 2010.
- There are no comments yet. Be the first by adding your thoughts above.


text: Rhys Williams is afforded the leading role in Columbia's Tyrant of the Sea. The film borrows a few pages from Jack London's The Sea Wolf by depicting Captain William Blake (Williams) as a power-hungry despot, who runs his ship like a private fiefdom. In contrast, Blake is a perfect gentleman on shore, especially when dealing with his pretty daughter Betsy (Valentine Perkins) and her various beaux. The story comes to a rousing climax during a pitched sea battle between English and French vessels, with Captain Blake not only contending with the enemy, but with a mutinous crew. Some of the action highlights have been culled from Columbia's stock-footage library, which did yeoman service for producer Sam Katzman. ~ Hal Erickson, Rovi


text:
National Briefing | Plains: Kansas: Governor Proposes Budget Cuts
By Jodi Wilgoren (NYT)
Published: December 15, 2001
Gov. Bill Graves proposed budget cuts of nearly 10 percent, or $426 million, reducing financing for schools, canceling highway construction projects and cutting Medicaid benefits. Mr. Graves, whose proposed $100 million tax increase was recently defeated in the Legislature, said the cuts would be needed because of declining revenues and rising Medicaid case loads. Some lawmakers have suggested expanding legalized gambling to avoid budget cuts and new taxes. Jodi Wilgoren (NYT)


text:
iHerb Customer Reviews
Skin Care
1 person found the following review helpful
Posted by Reviewer2564270 on Apr 20, 2009
I started using it to improve my skin condition, it seems to be a little improved too early for the full effect.
inproving constipation
Posted by 5219788476217161666 on Nov 24, 2012
I tried the ones from NewChapter & didn't work, these work wonders, take 2 at night then 2 the next morning & wait for the next 24hrs, you'll feel right like rain, only drink water,
Posted by Reviewer2326168 on Apr 28, 2015
Bought this for digestive and colon health. It is working great! Will probably re-order.
To be continued. . .
Posted by Reviewer3186389 on Sep 06, 2009
this is a long term natural remedie/suppliment which cannot be rated so soon! My one small criticism is compared with my previous brand. . . there is an unpleasant taste and I would suggest it be taken with a strong fruit juice chaser.
aloe vera
Posted by Reviewer2339168 on Aug 23, 2011
all ordered products received on time. I've used Solgar Aloe Vera for several months and it helped me very much.


text:
Bath Expert
- +
- New rand protecting leather just above the sole. Very comfortable from the start.
- −
- Nope
|Value for money
|Overall rating
Published on: 22 September 2015
Mens SL Activ Boot
The definitive hill and mountain all-rounder, the Scarpa SL Activ delivers the perfect combination of support, flex and protection.
As the latest generation of the SL - Scarpa's legendary 3-4 season boot - the SL Activ has some pretty big boots to fill. Not to worry: the SL still offers fantastic support and grip on demanding terrain, but with added comfort for multi-day use. Sturdy enough to take a walking crampon when needed but flexible enough to use as a hill walking boot, the SL is a stunningly versatile piece of kit.
From the stiffening materials within the boot which provide tailored, unobtrusive support, through the shape of the padding around the ankle, right down to the design of the lacing eyelets to ensure the boot wraps securely around your foot, Scarpa's attention to the comfort of your feet in the SL is incredible. As well as providing comfort and support, the SL uses sturdy Sherpa leather and sports a high rubber rand for dependable, durable protection.
If you're looking for a boot to take you from Snowdonia's craggy peaks to Everest Base Camp, look no further than the SL.
FREE STANDARD UK DELIVERY on orders over £30
Product Features
Alternatively, you might like these
No Place too Far
Scarpa are an Italian footwear manufacturer that combines a proud history of traditional hand-made craftsmanship with modern and innovative approaches to boot manufacture. This has enables the family run company to develop a range of hiking boots, approach shoes, mountaineering boots and rock shoes that are considered amongst the finest in the world. With their history and their future working in harmony, Scarpa are able to look forward with confidence, and innovate freely.


text:
The new Yardbarker app is here! Install on your iPhone, iPad or Android device. You can also find us in Google Newsstand.
Giants Re-Sign G John Jerry
The New York Giants announced Friday that they've re-signed veteran G John Jerry. Jim Wyatt of the Tennessean reported earlier in the day that the Titans were hosting Jerry for a visit on Friday. Jerry, 28, is a former third round pick of the Dolphins back in 2010. He played out his rookie contract with the Dolphins before signing a ...
Via NFL Trade Rumors
March 13, 2015 | Discuss
Offensive Line Quarter Pole Review: Pulling Guards Driving Interior
John Jerry was a driving force behind the Giants big day on the ground in Week 3 (recorded a 2.0 run blocking grade). I'd estimate that on nearly half of the Giants' runs Jerry pulled play side leading the way (in lieu of a fullback, which the Giants have rarely used this season) for the back. Jerry shows great footwork and balance getting to the second level. More often then...
Via Ultimate NYG
October 02, 2014 | Discuss
Mailbag: New York Giants draft talk and John Jerry concerns
The offseason is well underway now and, to the surprise of many, the New York Giants have accomplished quite a bit. They have bolstered their defense through an assortment of free-agent signings and even improved the offensive line—the team's greatest weakness in 2013—with big additions, such as guard Geoff Schwartz. This week's mailbag answers a few questions that look ahead...
Via cover32 - Giants
March 26, 2014 | Discuss
Giants Sign Former Dolphins OG John Jerry
Conor Orr of The Star Ledger reports that the Giants have signed former Dolphins OG John Jerry. Jerry, 27, graded out positively as a pass blocker last season but struggled in the run game and graded out as the No. 43 guard out of 81 qualifiers. Jerry was one of the offensive lineman involved as part of the bullying scandal that occurred last season with the Dolphins. Jerry will...
Via NFL Trade Rumors
March 21, 2014 | Discuss
Incognito, Jerry and Pouncey all implicated in Ted Wells report
Ladies and Gentleman the moment you have all been waiting for….. Ted Well's investigation is finally out : http://nfldolphinsreport.com/ The Report says Martin's teammates "did not intend to drive Martin from the team or cause him lasting emotional injury." It contributed tho — Ian Rapoport (@RapSheet) February 14, 2014 The report did have some damaging information...
Via cover32 - Dolphins
February 14, 2014 | Discuss
Dolphins Injury Report: G John Jerry Ends Week Listed As Probable
The Miami Dolphins have released their Friday injury report and it includes a little bit of good news for them as guard John Jerry (concussion) returned to practice on a limited basis. Jerry is listed as probable and signs point to him playing Sunday against the Pittsburgh Steelers baring a setback. Also listed as probable […] Dolphins Injury Report: G John Jerry Ends Week Listed...
Via Steelers Depot
December 06, 2013 | Discuss
Dolphins Injury Report: Starting RG John Jerry Sidelined With A Concussion
The Miami Dolphins Wednesday injury report is now in as they prepare to play the Pittsburgh Steelers this coming Sunday at Heinz Field. Players listed as not practicing on Wednesday are guard John Jerry (concussion), cornerback Jamar Taylor (hamstring) and running back Daniel Thomas (ankle). Jerry has started every game for the Dolphins this season at right guard and would likely...
Via Steelers Depot
December 04, 2013 | Discuss
Giants News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter


text:
Star Tracks
A shaded Garner steps out for some sun in Santa Monica, Calif. Plus: Kellan Lutz, Christina & Matt, Prince Harry and more
Credit: Noel Vasquez/Getty
Updated: Friday Mar 30, 2012 | 05:00 PM EDT
More from PEOPLE
Latest News!
- Boy Accidentally Shot Dead by His Older Brother During Target Practice in Ohio
- Read the Cover Story: At Home with Donald Trump and Family!
- Ashley Judd Says She Was Sexually Harassed by Studio Executive – and Other Actresses Were, Too: 'We Internalize the Shame'
- VIDEO: From Shirley Bassey to Sam Smith, James Bond Movie Theme Songs – Ranked
- Lauren from Fordham University: Tom Hanks Has Found Your ID and Is Looking for You!


text:
Offshore rig driller Seadrill is facing another two years in the doldrums but hopes the international rig market could turn around in 2017.
Rig rates have more
Italian oil company Eni has received permission from Norway's Petroleum Safety Authority to extend the use of a service rig on its troubled Arctic Goliat oil field offshore Norway until Nov.
Loading of tankers suspended, unclear when it will resume.
Oil spilled into the North Sea during the loading of a tanker at Norway's Statfjord field on Thursday, operator Statoil said.
Mario Cordero was reconfirmed today as a U.S. Federal Maritime Commissioner.
Cordero joined the Federal Maritime Commission (FMC) as a Commissioner on June 3,
The Port of Cleveland and its partner Kurtz Bros., Inc. have scored their first major user in the Port's effort to market sediment for beneficial use.
Great Lakes Construction, Co.
Three former executives of ocean freight shipping firms have been indicted for participating in a long-running price-fixing conspiracy, the U.S. Justice Department announced.


text:
"I wanted to drop you a note to thank you for your kindness, caring, and professionalism dealing with the death of my grandmother, C. S. From the moment you arrived to pick up Gram all the way through to us leaving the cemetery, I was so touched by everyone there. You did a beautiful job and I know Gram would have been pleased. Thank you again and bless you for all you do."
Online Obituaries
Kimball John Thomas
December 10, 1956 - November 12, 2012
Kimball J. Thomas, age 55, of Naperville, IL formerly of Rutherford, NJ. Passed away, Monday, November 12, 2012 at his home. Born December 10, 1956 in Rutherford, NJ. Loving father of Taylor and Trent Thomas. Loving step-father of Madison Schlenbecker. Beloved brother of Sherry Thomas and Lee Thomas. Fond uncle of Cristina Thomas. Preceded in death by his: father, Walter L. Thomas, mother: Amy Livingstone, Step-father: Reggie Livingstone. Kimball had been a Naperville resident for 20 years.
In lieu of flowers, memorials to: Taylor and Trent Thomas Education Trust Fund (payable to E. Barry Greenberg & Associates, Ltd.) c/o The Greenberg Law Firm, 55 South Main Street, Suite 359, Naperville, IL 60540, Phone: 630.416.4747.
Memorial Service: Friday, November 23rd 2012 at 11:00 AM at Grace Pointe Church, 1320 East Chicago Ave., Naperville, IL 60540.
Interment is private.
For more information, please call 630-355-0213


text:
What is S&T?
What is S&T?
The WSO Advantage - Investment Banking
Financial Modeling Training
IB Templates, M&A, LBO, Valuation + Learn More.
IB Interview Prep Pack
30,000+ sold & REAL questions Learn More.
Resume Help from Actual IB Pros
Land More IB Interviews. Learn More.
Find Your Perfect IB Mentor
Realistic IB Mock Interviews. Learn More.
Comments (10)
- pedigreed monkey
- (Senior Orangutan, 422 )
- on 8/27/07 at 5:51pm
sales and trading, like the people that sell bonds/stocks to big investors/wealthy individuals or the different types of traders like floor traders or prop traders. some traders match up buyers and sellers (market makers) some make money for the firm off the spread (i think? the liars poker type traders... dont know what these are called)
- analyst123
- (Monkey, 59 )
- on 8/27/07 at 5:52pm
prop traders
- AgreeWitMe
- ?
- (Orangutan, 363 )
- on 8/27/07 at 7:26pm
It's too bad this forum has been reduced to answering questions like what is sales and trading.
Especially bad when the question comes from someone with 207 bananas1
- mark klein MD
- ?
- (Senior Orangutan, 432 )
- on 8/27/07 at 7:55pm
Well hopefully AgreeWitMe is just using sarcasm, which would make sense given the ridiculous question asked in the first place.
I want to work now! No, really. I want those 100+ hours/week.
- beaker
- (Senior Baboon, 180 )
- on 8/28/07 at 5:31am
I find it funny that this question was asked in the IB forum.
- Arch Pei
- (Senior Chimp, 29 )
- on 8/28/07 at 6:15am
Related Content on Wall Street Oasis
- I what ways does corporate banking dept. interact with S&T?
- What's more math based: IB or S&T?
- So everyone's quitting their IBD gigs- What about S&T?
- Summer Analyst: MM IBD or BB S&T?
- AM back to BB S&T?
- Prospective Banker to Prospective S&T?
- Barclays Capital Summer Analyst-- How many from target school each year at S&T?
- Why not S&T?
- AgreeWitMe
- ?
- (Orangutan, 363 )
- on 8/28/07 at 9:35am
To unlock this content for free, please login / register below.Connecting helps us build a vibrant community. We'll never share your info without your permission. Sign up with email or if you are already a member, login here Bonus: Also get 6 free financial modeling lessons for free ($200+ value) when you register!
These 6 FREE Financial Modeling Lessons
Can Help You Land Your $100k+ Dream Job
- Our Fun Excel Training and Challenge Contest
- DCF Modeling, Tons of Free Templates & Video Tutorials
- Valuation Lesson on Trading Comps
- Cash Flow Modeling and more!
6 Free Financial Modeling Lessons...and More.
Enter e-mail to get our Modeling Tutorials (Worth $200+)
Popular Content
- HEY you OCR little f*cksshit on me all you want because idgaf!!!! all your fate is mine, you little f*ckers i volunteered to do ocr because i thought it'd be a nice break but F*CK i'd rather be hunched over my desk than be dealing with these borderline terrifying besuited assailants. first of all, GOD...
- How do you CRUSH your interviews? In 2007 I made my hardest career transition. After leaving Goldman Sachs and taking eighteen months off work, I decided...
- WSO Investment Banking Resume Template for College Students Released to the Public!Big Announcement: WSO Resume Template is Out in the Wild!: Mod Note (Andy): If you're looking for our resume for experienced IB professionals or a <a...
- Three Things You Didn't Know About Becoming A Rock-Star AnalystMod Note (Andy): #TBT Throwback Thursday - this was originally posted on 6/21/12. At the beginning of my analyst program i had a fixed-notion of what it takes to become one of the top-ranked analysts in my class, pocket top-bucket bonus and move on to a prosperous future...
- INTRODUCING: The WSO Applicant Database. Take 5 minutes on WSO to Reach Hundreds of Finance Recruiters and Finance CompaniesGiven that we have built up relationships with hundreds of companies and finance recruiters, we thought instead of just a simple job board (which you can find right here), we would also create a WSO Applicant...
- WSO Campus Representative Program WSO is now accepting applications to be a Campus Rep at your university for the 2015-16 school year. We currently have 42 reps signed up but would love to add 20-30 more. We are looking for motivated students with a solid work ethic and strong presentation/communication skills who are...
- The Best IBD SA OCR, Interviews and FT Offer Conversion Posts on WSOThanks to my content intern @Lucas_m" for another great compilation post. This one covers on campus recruiting, interviews, and converting SA <a...
- How Finance is like Professional SportsIf you look at elite athletes of virtually any sport, they almost always share one thing in common: they started playing the sport at a fairly young age. Sure, there are exceptions, but very rarely do you see a world-class athlete who picked up the sport after high school. Now, what does...
- Why Your Salary Matters to HerMod Note (Andy): Best of Eddie, this was originally posted in January 2011. When women get together with their friends and talk about the new guy in their life, one of the first questions that always comes up is, "What does he do?", which - let's face it -...
- Financial & Valuation Modeling Boot-CampFinancial modeling is a skill that any investment banking analyst will have to master. Although the majority of <span...
Forum Topics
- OCR: The Saga Continues (Alternate Title: I Now Have Cancer of the Nose)Mod Note (Andy): See his original post here: "HEY you OCR little f*cks" all schools are apparently filled with tweedledees and tweedle f*cking dums because all of the atrocities that led to my...
- What is the scope of Collateral Management/Margin Calls as a career path?I have been offered a profile of "Margin Collateral Valuations Pricing - Analyst". I would like to know few details on : 1. The average compensation benefits (industry standards) 2. Career path...
- 3-6 Year Horizon ETFs & Index FundsI stopped being broke. Looking to invest some cash passively and shit. Suggestions? Much appreciated!
- Algo-HFT trading exit optionsI have been an algo-HFT trader for a top firm for a few years now. However I get the feeling that its time to move on. If someone here could shed some light on possible places/jobs to go to from here...
- Semi-target junior seeking resume advice - will give sbs for help!Please help, my deadline is coming!
- Girlfriend and business schoolHas anyone had issues keeping a relationship when they went to graduate school? I mentioned to my girlfriend last night that I was considering starting an MSF program in September, and she flipped...
- Top Schools that will offer FULL TUITION merit based only (no financial need) Ok, so im brand new here. I need some help because i am absolutely clueless about colleges and the like so bear with me... I am a senior. Priority deadlines for most colleges is in 1 month from now...
- What is family life like in finance?I've always wondered how people juggle their job and family while also being in a very time-demanding field. While I don't intend on having kids until my early 30s, I would never want my kid to think...
- Opinions on Point72 University programPoint72 Asset Management 15-months long training "University" has already been detailed in BI. (Link: http://www.businessinsider.com/point72-academy-201... ). Opinions ? People in the program are...
- How to break in the finance industryI am 24 years old, graduated from USC in Dec 2013. I passed the CPA Exam and CFA Exam Level I & II. I have worked as Revenue Accountant in private industry for a year. About to get certified as...
- CBRE vs. JP MorganI am a senior Finance and Marketing major with a certificate in investments. I would like feedback on two different options, CBRE vs JP Morgan. CBRE: I would be a financial analyst and could after...
- Career Advice for AMHi All. I am new to this forum seeking some career advice, as it seems there is a wealth of knowledge here! I am a real estate Asset Manager currently working for an operating partner of a large...
- Enterprise Value technicalSuppose EV=200; no prefs or minority. Net Debt is 400. How much is Equity? If Equity is 0, what's going on here? How many cents on the dollar is this debt trading? Can anyone walk thru the correct...
- Need to Interview someone that is in/was in ER for College PaperHi everyone, I'm looking for someone in Equity Research to do an interview with for a college paper. The interview will last under half an hour and it can be done through Skype, phone call, or even...
- Difference between PE & Corp DevHi, Now that I've been in my new Corp Strat/Dev for a bit , I'm trying to get a better sense of the biggest differences between PE and Corp Dev (besides the obvious pay, prestige, etc) as well as...
Top WSO Members
|Banana Points
|Edmundo Braverman
Upcoming Events
- Oct 5 2015 - 9:00am to Oct 6 2015 - 9:00am
- Oct 6 2015 - 6:00pm
- Oct 7 2015 - 8:00am to Oct 8 2015 - 8:00am
- Oct 7 2015 - 8:00am to Oct 9 2015 - 5:00pm
- Oct 7 2015 - 7:00pm to 9:30pm
Silver banana leaders
|Silver Bananas
|Edmundo Braverman


text: Book Review: Fort McHenry (Scott Sheads) : MH HistoryNet Staff 8/12/2001 Fort McHenryby Scott Sheads, The Nautical and Aviation Publishing Company of America, Baltimore, Md., 1996,$26.95. Fort McHenry is the third book on Baltimore's famous "star fort" by one of today's most gifted historians of the largelyforgotten War of 1812. Scott Sheads–a National Park Service ranger at the fort for many years and a member of thelegendary Fort McHenry Guard–has years of research in the fort's primary archival resources behind him. From it he hascrafted an engaging and highly readable account that covers more than two centuries of the famed structure's history–includingthe 1814 British bombardment that inspired Francis Scott Key to write "The Star-Spangled Banner," which became thenational anthem of the United States in 1931. With 60 period portraits and battle scenes (19 in color), 10 appendixes, notesand a bibliography, this book is likely to remain the standard treatise for several years to come. Blaine Taylor Leave a Reply Cancel Reply Your email address will not be published. Name* Email* Website Comment


text:
HE SAID WHAT? — "My goal is to win a championship. I know I'm a little old and a little sick. But I'll be around until we make the … championship. I'm a little stubborn like that." — Eighty-four-year-old Washington Wizards owner Abe Pollin
Williams sisters
Venus and Serena are cruising toward another Wimbledon final exhibition match.
Shawn Chacon
He pushes general manager Ed Wade to the floor and loses his job with the Astros. They would love him in Philadelphia.
Baron Davis
The ultimate test of the NBA free agent class — does he go for green or a legitimate title opportunity?
Alex Rodriguez
Because he won't hit in the home run derby? No, because he has been linked to Madonna.
Tiger Woods
His surgery will shelve him into next season and apparently keep good golfers away from his tournament.
And we're not including Gilbert Arenas, who appears ready to stay with the Wizards when he returns home from China.
1. Elton Brand — If he comes back healthy, he's one of the best bigs in the NBA.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Nov 28, 1995
|Filing date
|Jul 18, 1994
|Priority date
|Nov 4, 1993
|Fee status
|Also published as
|Publication number
|Clarke Slemon, Bob Macel
|Original Assignee
|Torcan Chemical Ltd.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (2), Non-Patent Citations (1), Referenced by (17), Classifications (10), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a division of application Ser. No. 08/145,572, filed Nov. 4, 1993 and now issued as U.S. Pat. No. 5,374,730 dated Dec. 20, 1994.
This invention relates to omeprazole and lansoprazole, and more particularly to novel synthetic methods for their preparation.
Omeprazole, which has the chemical structural formula: ##STR1## is a known gastric acid secretion inhibiting agent, and is prescribed clinically for the prevention and treatment of gastrointestinal inflammatory diseases in mammals including man, for example gastritis, gastric ulcer and duodenal ulcer. Lansoprazole, which has the chemical structural formula: ##STR2## has similar pharmaceutical activity and medicinal uses.
The reported syntheses of omeprazole basically involve the synthesis of the corresponding thioether compound, of the formula: ##STR3## and its subsequent oxidation to the sulfinyl or sulfoxy compound, omeprazole, by various methods such as reaction with hydrogen peroxide over a vanadium compound catalyst (Canadian Patent 1,263,119 Takeda), reaction with peracids, peresters, ozone, etc. (Canadian patent 1,127,158). Lansoprazole similarly is produced by oxidation of the thioether compound of formula: ##STR4## There are certain disadvantages associated with these processes, largely derived from the nature of the thioether (or sulfide) compound being oxidized.
One of these disadvantages derives from the physical nature of the thioether itself. Under ordinary conditions of temperature and pressure, it is an oil, not a crystalline solid. Accordingly, it is very difficult to purify, since it cannot be subjected to precipitation and crystallization procedures to remove impurities from it. This leads to complications in the processes for purifying the resultant omeprazole.
Another disadvantage associated with both omeprazole and lansoprazole derives from the discolouration of the final product made by oxidation of the thioethers. A red discolouration of the crude products is commonly experienced, and is very difficult to avoid, using this oxidation process. Omeprazole and lansoprazole are inherently unstable molecules in weakly acidic conditions, tending to rearrange to produce annoying highly coloured decomposition impurities.
It is an object of the present invention to provide a novel process for the preparation of omeprazole and lansoprazole, which overcomes or at least reduces one or more of the disadvantages associated with prior art processes.
According to the present invention, it has been discovered that amide analogues of the thioether compounds A and B, i.e. compounds meeting the general formula: ##STR5## can be readily oxidized to the corresponding sulfinyl compounds. Then the sulfinyl compounds can by hydrolysed in alkaline medium to the corresponding carboxylic acid salts which can be decarboxylated to omeprazole or lansoprazole, as the case may be.
This process offers a number of significant advantages. Some of these relate to the purity in which the final products can be obtained, and the simplicity of the purification procedures which can be adopted to achieve high purity. For example, the amide compounds which are subjected to the oxidation step are crystalline solids, as opposed to oils, so that they are readily purified to a high degree of purity by relatively simply precipitation, crystallization and washing procedures. The carboxylates and carboxylic acid salts which are formed in the next synthetic step after oxidation are water soluble, whereas the final products, omeprazole and lansoprazole, are not. Accordingly, any unreacted residues of these compounds and many other minor impurities in the final products are simply removable by an aqueous washing procedure.
Another significant advantage derived from the process of the present invention is in the avoidance of significant discolouration of the product. In the prior art processes in which a thioether of formula A or B above is subjected to oxidation, mildly acidic conditions are usually required, and a red discolouration of the product is very difficult to avoid. While it is not intended to be bound by any particular theory of the reaction mechanism or by-products responsible for this discolouration, it is believed that interaction of the nitrogen group on the pyridine ring with the S-C-N grouping involving the azole--thioether linkage occurs, creating a conjugated system. Such a conjugated system of S and N atoms would be expected to be highly coloured. These mechanisms have been extensively studied [J. Org. Chem., 1987, 52, 4582-4592].
In the process of the present invention, this problem is not encountered. Acidic conditions for the oxidation and other chemical steps in the synthesis are not necessary, so that the instability leading to the formation of the coloured compounds is largely avoided.
It is further to be noted that the amide compound appears to be unique in the combination of its ability to undergo oxidation from the thioether to the sulfinyl compound, and in its relative ease of subsequent hydrolysis to carboxylate. Analogous thioether compounds substituted at the same positions with other carbonyl groups, for example --COO-- lower alkyl, or with a nitrile group, do not oxidize to sulfinyl, at least under acceptable, practical conditions. In addition, the fact that the amide compound according to the invention, following oxidation, can itself be hydrolysed readily to carboxylic acid or salt is surprising in itself. Normally such hydrolyses of compounds of this nature are extremely difficult, if not impossible, to conduct. In the present case, however, substantially complete hydrolysis is achieved, on heating with an aqueous alkali such as sodium hydroxide, in a time of about three hours.
Thus according to one aspect of the present invention, there is provided a process for preparing a pyridine-benzimidazole sulfinyl compound of formula (I): ##STR6## in which either (a) R and R1 are both methyl and R2 is methoxy; or (b) R is 1,1,1-trifluoroethyl and R1 and R2 are both hydrogen, which comprises oxidizing an amide of formula (II): ##STR7## to produce the corresponding amide sulfinyl compound; subjecting the amide sulfinyl compound so formed to alkaline hydrolysis to form a sulfinyl carboxylate, or salt thereof, of formula (III): ##STR8## in which X is an alkali metal, Y is hydrogen or a metal, or X and Y together represent a divalent alkaline earth metal; and decarboxylating the sulfinyl carboxylate of formula (III) to form the sulfinyl compound of formula (I); the groups R, R1 and R2 in formulae (II) and (III) having the same meanings as given above, and the group R3 in formula (II) above representing hydrogen, lower alkyl or aryl-lower alkyl, optionally further substituted by other functionality to assist in the hydrolysis step.
When choice (a) for the various radicals is made, the end product is omeprazole. When choice (b) is made, the end product is lansoprazole.
The compounds of formula (II), the compounds of formula (III) and the compounds of formula (IV) above are novel chemical compounds, and form further aspects of the present invention.
The oxidation of the amide of general formula II can be conducted using a wide variety of oxidizing agents, such as those previously proposed for use in oxidizing thioether compounds of formula A in the synthesis of omeprazole. These include the use of hydrogen peroxide as oxidizing agent (with or without catalysts). Other oxidizing agents which can be used include peracids, permanganates, tris(trimethyl) peroxide, N-bromo(chloro)succinimide, 1,3-dibromo-5,5-dimethylhydantoin, 2-hydroperoxyhexafluoro-2-propanol, iodosyl benzene, manganese (III) acetylacetonate, oxygen (with or without a catalyst), peroxy monosulfate, ruthenium tetroxide, perborate, periodate, acyl nitrates, t-butylhydroperoxide, dimethyl dioxiranes, hypochlorite, cerium ammonium nitrate, 2-nitrobenzenesulfinyl chloride/potassium superoxide, N-sulfonyloxaziridines, sodium bromite and benzoyl peroxide etc. The oxidation is suitably conducted in an aqueous or polar organic solvent medium, depending upon the choice of oxidizing reagents, and under other conditions such as temperatures and pressures commonly used in organic synthesis when working with the chosen oxidation system. The oxidation process normally leads to the formation of a mixture of the two diastereomers, reflecting the different configuration around the sulphur group. It is unnecessary to separate these isomers.
Particularly preferred among the oxidation systems is the use of hydrogen peroxide with an organic vanadium compound as catalyst, such as vanadyl bis(acetylacetonate), which gives particularly high yields of sulfinyl compound, in relatively short periods of time.
The starting amide material of formula II and the amide-sulfoxide of formula IV and the carboxylate salts of formula III are all solid, crystallizable compounds, so that they can be readily precipitated from solution for ease of purification by simple washing procedures. This is to be contrasted with the prior art processes described above, where the thioether prior to oxidation and the sulfinyl compound after oxidation are oils or low melting solids, and therefore very difficult to purify. The oxidation process is a smooth, clean reaction of one crystalline solid to an isolatable stable sulfoxide, as a mixture of diastereoisomers without the use of acid likely to cause degradation and without significant risk of over-oxidation to lead to discolouration.
The sulfoxides (sulfinyl compounds) so formed are surprisingly stable. One expects sulfoxide compounds with electron attracting groups to undergo spontaneous Pummerer reactions, whereby the oxygen of the sulfoxide group is lost to form a hydroxyl group on the adjacent, carbonyl-carrying carbon atom [Elmer Schroeder and D. M. Dodson, J. Am. Chem. Soc., 84, 1904 (1962)]. This does not appear to occur with the sulfinyl compounds used in the process of the present invention.
The sulfinyl-amide compound of formula II is next subjected to hydrolysis, to form the corresponding carboxylic acid salt. Surprisingly, as noted above, this can be readily accomplished simply by heating with an aqueous alkali, suitably sodium hydroxide solution, so as to obtain the alkali metal salt of the carboxylic acid. Normally one encounters difficulties in achieving hydrolysis of amides of this type, perhaps due to steric hindrance effects or the presence of competitive reactive groups in the molecular structure.
The salt form can be isolated and used in the decarboxylation step or it can be converted in situ. The salt is a solid at ordinary temperatures, so that recovery and purification is relatively easy and straightforward. It is water soluble. Following the recovery of the salt, it can be heated in solution to effect decarboxylation and formation of omeprazole or lansoprazole, as the case may be. In a preferred embodiment of the invention, the salt is not isolated but is warmed in situ in a solvent medium in which it is soluble but in which the product, omeprazole or lansoprazole, is not. The product as it is formed crystallizes out. These final compounds are insoluble in water. The use of the salt form for decarboxylation purposes, with the attendant avoidance of acidification to acidic pHs, removes further risk of discolouration of the end product as discussed above. It appears that the compounds of general formula III have sufficient internal acidity for the decarboxylation reaction, derived from the proton associated with the imidazole ring system, so that neutral or even weakly alkaline conditions can be adopted for this reaction, if desired.
The end product omeprazole or lansoprazole produced by the process of the present invention is easily and simply purified from the residual, unreacted salt, inorganic by-products and other minor by-products by a washing procedure. The desired end products are insoluble in water and lower alkanol solvents, whereas the starting materials and byproducts are soluble therein. Consequently, solvent extractions, filtrations and washings are all the steps that are necessary to obtain the end products in highly purified form.
While the acetamide thioether compound of formula II above, the starting material for the process of the present invention, is a novel compound, processes for its preparation will be readily apparent to the skilled organic chemist.
These include:
(1) reaction of the appropriately substituted 2-halo-mercapto-benzimidazole with the appropriately substituted 2-methyl-amido-pyridine, thus: ##STR9##
(2) reaction of the appropriately substituted 2-pyridine carboxylate with appropriately substituted 2-S,S-bis-(benzimidazole), followed by reaction with ammonia, thus: ##STR10##
(3) reaction of the appropriately substituted 2-halo-pyridine with the appropriately substituted 2-(methyl-carboxylate)-thio-benzimidazole, followed by treatment with ammonia, thus: ##STR11##
(4) reaction of the appropriately substituted 2-halomethyl-amido-pyridine with the appropriately substituted 2-mercapto-benzimidazole, thus: ##STR12##
(5) reaction of the appropriately substituted 2-mercaptomethyl-amido-pyridine with the appropriately substituted 2-halo-benzimidazole, thus: ##STR13##
The invention is further described, for illustrative purposes, in the following specific examples.
A pyridine--thioether--benzimidazole acetamide of formula II, in which R2 was methoxy, and R and R1 were both methyl, was oxidized to the sulfinyl (sulfoxide) compound.
92.0 g of the amide compound substrate and 920 ml acetone were cooled to 0� C. and 0.4 g of vanadyl bis(acetylace-tonate) was added. With stirring at 0� C., 38.6 ml of 30% hydrogen peroxide was added. After stirring for one hour at 0�-5�, the mixture was warmed to 20�-22� and left stirring for 1 hour. By HPLC, it was determined that less than 1.5% starting material remained. The mixture was cooled to 0� and filtered. The solid was washed with acetone at room temperature until the filtrate was colourless. Finally the solid was washed with a small amount of hexane, and dried at about 40 degrees in vacuum. 86.25 g (90%) yield of the sulfoxide compound was obtained, as a mixture of the two stereoisomers.
The amide sulfoxide product of Example 1, 2-(5'-methoxy-2'-benzimidazolylsulfinyl)-2-(3,5-dimethyl-4-methoxypyridyl)acetamide sodium salt, was converted to the corresponding acetic acid sodium salt by hydrolysis, and then thermolyzed to give omeprazole.
1.00 g of the amide sulfoxide substrate in 5 mL of 10% sodium hydroxide was heated under nitrogen in an oil bath at 50 degrees. The transformation from amide to carboxylate was monitored by HPLC. The reaction was essentially complete in three hours. The mixture was acidified with carbon dioxide and the intermediate 2-(5'-methoxy-2'-benzimidazolylsulfinyl)-2-(3,5-dimethyl-4-methoxypyridyl)sodium carboxylate was extracted into 1:1 v/v isopropanol-toluene. The solution was refluxed for 20-30 minutes and the transformation of the carboxylate into omeprazole was monitored by HPLC. The organic mixture was evaporated and the organic materials dissolved in warm isopropanol and filtered to remove inorganic residues. The solution was stirred and cooled to give slow crystallization of a cream coloured solid. The solid was filtered and washed with cold isopropanol and with hexanes. Yield--0.37 g.
Omeprazole was produced from 2-(5'-methoxy-2'-benzimidazolylsulfinyl)-2-(3,5-dimethyl-4-methoxypyridyl) acetic acid dipotassium salt substrate, as follows:
1.0 g of substrate was dissolved in 1.0 ml water and mixed with 10 ml of a bisulfite solution pH 4.8, which was prepared by combining 5.0 gm of sodium metabisulfite with 75 ml water and 25 ml of methanol. The pH of the total reaction mixture was 7.2. Gradually at room temperature with stirring, 35 drops of glacial acetic acid were added from a disposable pipette, bringing the pH to 4.8. Vigorous gas evolution was observed and the solution became cloudy, then oily. 2.0 ml of methanol was added and the mixture seeded with omeprazole; solid began to precipitate. The reaction was allowed to proceed for 30 minutes. The solid was filtered, washed with water, and then some acetone. Drying gave 0.45 g of off-white omeprazole free of any substantial impurities.
|Cited Patent
|Filing date
|Publication date
|Apr 5, 1979
|Mar 10, 1981
|Aktiebolaget Hassle
|Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
|Jul 29, 1985
|Dec 9, 1986
|Takeda Chemical Industries, Ltd.
|Citing Patent
|Filing date
|Publication date
|Dec 4, 1998
|May 15, 2001
|The Dow Chemical Company
|Soft and flexible foams made from blends of alkenyl aromatic polymers and alpha-olefin/vinyl or vinylidene aromatic and/or sterically hindered aliphatic or cycloaliphatic vinyl or vinylidene interpolymers
|Feb 22, 2000
|Mar 5, 2002
|Sepracor, Inc.
|Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
|Feb 22, 2000
|Mar 26, 2002
|Sepracor Inc.
|Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
|Jan 11, 2000
|Dec 3, 2002
|The Curators Of The University Of Missouri
|Substituted benzimidazole dosage forms and method of using same
|Jan 10, 2002
|Apr 15, 2003
|Sepracor, Inc.
|Methods of treating gastro-esophogeal reflux disease using (-) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
|Jan 10, 2002
|Apr 22, 2003
|Sepracor Inc.
|Methods and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
|Jul 9, 2001
|Nov 11, 2003
|Curators Of The University Of Missouri
|Substituted benzimidazole dosage forms and method of using same
|Jan 19, 2002
|Mar 2, 2004
|The Curators Of The University Of Missouri
|Substituted benzimidazole dosage forms and methods of using same
|Sep 30, 2002
|Aug 24, 2004
|The Curators Of The University Of Missouri
|Substituted benzimidazole dosage forms and method of using same
|Feb 25, 2000
|Feb 8, 2005
|Nitromed Inc.
|Methods using proton pump inhibitors and nitric oxide donors
|Aug 1, 2003
|May 1, 2007
|Nitromed, Inc.
|Nitrosated proton pump inhibitors, compositions and methods of use
|Jun 14, 2004
|Feb 19, 2008
|Nitromed, Inc.
|Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use
|Nov 28, 2005
|Aug 26, 2014
|Santarus, Inc.
|Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
|May 25, 2005
|Dec 9, 2014
|Santarus, Inc.
|Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
|Jan 24, 2006
|Mar 31, 2015
|Santarus, Inc.
|Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
|Jun 14, 2004
|Dec 30, 2004
|Nitromed, Inc.
|Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use
|Dec 20, 2007
|Oct 14, 2014
|The Curators Of The University Of Missouri
|Omeprazole solution and method for using same
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Mar 12, 1999
Owner name: TORONTO-DOMINION BANK, THE, CANADA
Free format text: SECURITY INTEREST;ASSIGNOR:TORCAN CHEMICAL LTD.;REEL/FRAME:010018/0327
Effective date: 19980914
|May 13, 1999
|Fee payment
Year of fee payment: 4
|Jun 18, 2003
|Maintenance fee reminder mailed
|Nov 28, 2003
|Lapse for failure to pay maintenance fees
|Jan 27, 2004
|Expired due to failure to pay maintenance fee
Effective date: 20031128


text:
Great progress has been made, and the incidence of polio infection has plunged by more than 99 percent, from about 350,000 cases in 1988 to fewer than 2,000 in 2008. More than two billion children have been immunized in 122 countries, preventing five million cases of paralysis and 250,000 pediatric deaths. Today, polio remains endemic to only four countries: India, Pakistan, Nigeria, and Afghanistan.
Rotary club members worldwide have contributed more than $800 million and countless volunteer hours to the effort. Rotary is currently raising $200 million to match $355 million in challenge grants received from the Bill & Melinda Gates Foundation, all of it for polio eradication.
The money is needed to help close a funding gap that threatens to undermine two decades of progress. To learn more about polio eradication, including how to participate in this historic effort, visit rotary.org/endpolio today.
|SOURCE Rotary International
Copyright©2009 PR Newswire.
All rights reserved


text:
Sex ith animalsanimal sex library movies, anal animalsex videos, animal porn zebra movies, sexual fantasys and animals porn videos
Prize-winning photo from the catalogue: girls haveing sex with animals movies, Free animal sex online, beastiality sex with animals porn movies, fetish beastiality porn sites, bestiality porn free
watch free the movie 666 the beast, animalporn trailers, beast horse cum, porno of animals movies, beasty dog heaven
Share this video:
Free porn collection on categories: sex with animals free video download porn movies, beasttube zootube365 č xxx.animal porn videos
free adult xrated sex stories with animals porn videos, bestiality man horse video, guy having sex with animal, sexwomen with animals porn videos, teen fish fucking herself porn videos
Share this video:
Below you will find loads of porn and erotic on topic: bestiality death, Free sex with female animals gallery porn videos, dutch bestiality, gay beastiality porn beast male
animals sexcy movies, Sex ith animals č beastiality sex forums porn videos
animal sex oictures porn videos, Sex ith animals č the beasts houston zoo free porn
New HQ porn movies: beast fucking man porn movies, Men havin sex with animals porn movies, sex with animals texas porn videos, extreme animal sex planet porn movies
snake beasteality, Sex ith animals, porno con animales
zoo tube animal sex free porn movies, Sex ith animals, free hardcore beast sex vidoes
free movie trailers of beast sex, pictures of people having sex with animal free porn, free bestiality websites, bestiality video clip movies
pokemon animal sex free porn, xxx sex with animals cartoons movies, asian animal sex pics movies, beastiality horse mashroom inside movies
sanimal sex fuck videos movies, bestiality websites, girl+having+sexx+with+animal movies
animal porn minded videos, bestiality potoos free porn videos, extmere animal sex, pokemon animal sex free porn, asian beastiality porn movies
free porn movies girls fuck beasts, free pictures of animal sex, free pictures of girls having sex with animals videos
free animalk sex, free bestiality rape stories, free bestiality video trailers, lesbian bestiality stories porn videos, free downloadable beastiality porn videos
animal sex library movies
animalpornmovies, bestiality free, private bestiality, free pornanimal movies, beastie boys to all the girls porn movies
fetish beastiality porn sites, xxx fuck with animal porn videos, hot beastiality sex free porn, dogs and ladies bestiality
disney cartoon porn beastiality
New porn movies: fuck toon free beastiality cartoons only, Horse sex beastiality gay videos, sex determination in animals porn movies, animal porn men fucking goats
Updates on topics: 360zooporn, bestiality websites č gals and animals having sex
sex zoo porn, free zoo porn clips, animal farm sex sluts porn videos, huge cum of stallion cock, animalsexmovtes.blogspot movies
beasts denver zoo videos, beast sex chat sites, men fucking animals sex stories, animal wife sex video, animal porn minded
hot sheanimale sex videos, free movie sex with animals, homemade bestiality videos, free.beast sex
Im the hottest bestiality babe of the web!
Join my private site and watch all my uncensored dogsex and horsesex movies.
Adilia Private - Join Right now!
Tight Latina Horse-fucked


text:
The Adventures Of Bullwhip Griffin DVD
Price $14.99
5.05.0(1 review)See all 1 reviewWrite a Review
Classic Disney family-fun, this 1967 film follows the hilarious shenanigans of a young Boston stowaway, his reluctant and oh-so-proper British butler, and a collection of eccentric, comedic characters on a California-bound ship. Roddy McDowell, Suzanne Pleshette, and Karl Malden star in this movie about people determined to strike it rich in California gold fields.
Additional Details
DirectorJames Neilson, Arthur J Vitarelli
Primary CastRoddy McDowall Suzanne Pleshette Karl Malden More
Production Year1967
Technical Specs
- Format: DVD
- Rating: Not Rated
- Number of Discs: 1
- Run Time: 110 Minutes
- Region: 1
- Aspect Ratio: Widescreen
- Studio: Walt Disney Video
- DVD Release Date: April 12, 2005
- Closed Captioning: Yes
- Audio: ENGLISH: Dolby Digital Mono [CC]
- Color: Color
- Includes: cc, Dolby Digital Mono sound, Widescreen (1.66:1) - enhanced for 16x9 televisions
Reviewed by 1 customer
- Engaging Characters
- Entertaining
- Great Cinematography
- High Production Value
Best Uses
- At Home
- Travel
Comments about this product:
Really great performances by good actors/ Funny and entertaining.
You Might Also Like
Customer ServiceEasy Returns:
Satisfaction guaranteed.Safe Shopping:
Confidentially and privacy secured.FAQ:
Quick answers, easy solutions.


text:
nited States Agency for International Development's (USAID) Mission Director to Pakistan, Greg Gottlieb, presented the power distribution companies PESCO and IESCO with tools and maintenance vehicles at a ceremony at Rawal Grid Station in Islamabad.
The United States Embassy announces an additional contribution of $9.3 million to help the government of Pakistan meet the health, water, sanitation, and livelihood needs of internally displaced persons (IDPs) from the Federally Administered Tribal Areas (FATA). These funds will be provided through the United States Agency for International Development (USAID). The U.S. government will provide $7 million dollars to UNICEF/Pakistan to improve health, hygiene, water, and sanitation services for IDPs with the remaining funds used to ensure the health of livestock.
Last updated: September 09, 2015


text:
Best Part of Being A Part Of This Site
3 years ago
I get a lot of emails from so many of you and I try not to toot my horn, but I got this this morning and I'm really happy to share it with all of you!
"I don't know if you remember me but my name is Dennis, though you called me D.J. I met you at RTX last year and you dragged me into the studio to meet Monty because of my martial arts training. Because of that day you inadvertently inspired me to get back into very heavy training when I got home. Now because of you and that day I'm teaching martial arts to a small group of guys and loving every minute of it! So I would like to say thank you very much from the bottom of my heart for being my accidental muse and putting me back on a path I didn't realize I had missed. If you're ever in the Chicagoland area please come and train with us, you have unlimited free classes!
Thank you once again. If you wouldn't have had a little faith in me I probably wouldn't be back doing what I love.
My best regards and deepest thanks."
Thank you Dennis and yes I remember you :)
Comments (18)
Dopp ROLL TIDE
3 years ago
It's just the type of person you seem to be. Always wanting to be positive in everything you do. This is the turnout of that positivity.
3 years ago
That's awsome. :)
3 years ago
Thats so awsome.
3 years ago
Kathleen, you may be PT Jesus!
Newbs Rooster Speak & RT MN
3 years ago
Amazing things like this seem to happen on this site far too often. It shows how amazing this community is!
LaserKraken The Lord of Meat
3 years ago
Do I get partial credit for being Dennis's punching bag?
DiMono It's Back Baby!
3 years ago
I remember him, he was showing off some of his martial arts moves under the tent. Pretty cool guy.
3 years ago
This is where a production company really meets it's communiity, and thats what RT is fantasic with. Burnie has inspired me as a writer, I look up to him as if he was my father of comedy. I feel blessed that as an artist I have something to fuel my creativity and uplift me. And I found other creative minds that I like, which is the best gift of all.
Thank you, everyone.
3 years ago
Sounds like your BAMF abilites are rubbing off :P
3 years ago
Thats Kathleen for ya. Wandering through the RT community in search of greatness and helping, inspiring, and guiding others along the way.
Good stuff. See you at RTX 2012