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Select Local Merchants
Clarion Hotel AirportRead MoreProperty Location Located in Milwaukee (South Milwaukee), Clarion Hotel & Conference Center is within the vicinity of Mitchell Park Horticultural Conservatory and Discovery World. This hotel is within the vicinity of Marcus Center for the Performing Arts and Miller Park. Rooms Make yourself at home in one of the 180 guestrooms featuring refrigerators. Complimentary wireless Internet access is available to keep you connected. Conveniences include complimentary weekday newspapers and coffee/tea makers, and you can also request rollaway/extra beds. Rec, Spa, Premium Amenities Enjoy recreational amenities such as an indoor pool and a 24-hour fitness facility. Additional features include gift shops/newsstands and complimentary use of a nearby fitness facility. Dining Satisfy your appetite at the hotel's restaurant, which serves breakfast, lunch, and dinner, or stay in and take advantage of room service (during limited hours). Relax with your favorite drink at a bar/lounge or a poolside bar. Business, Other Amenities Featured amenities include a 24-hour business center, business services, and audiovisual equipment. Planning an event in Milwaukee? This hotel has facilities measuring 18000 square feet (1620 square meters), including banquet facilities. A roundtrip airport shuttle is complimentary (available 24 hours).5311 S Howell AveMilwaukee, WI US
Exec ParkRead MoreMost Popular Service: Quick, personalized parking and shuttle service Reservations/Appointments: Required Established: 1979 Staff Size: 2–10 people Pro Tip: Having travel documents in hand will make it easier when making parking reservations and checking in. Q&A with Kathy, President What is one of your signature services? How is it performed? Check-in and check-out take less than five minutes. No long lines to wait in to park and get the shuttle, and no crowded shuttle with luggage to have to walk over in order to get in and out of the shuttle bus. Besides making clients happy, what do you like most about your job? I love that we are a local, family-owned business and that our employees are all like family to us. Our employees stay with us for a long time, the shortest length of time anyone has been with us is 10 years. When and how did you first develop a passion for your work? Our family's passion has always been the airline industry. When we started Exec Park it was to fill a need that existed for off-airport parking options at Mitchell Field. Over the 35 years that we have been serving the parking needs of travelers using Mitchell Field, we have become friends with the many customers that have been parking with us year after year. [They] have been recommending us to their family and friends time after time. Is there anything else you want to add that we didn't cover? We are the oldest local, family-owned and operated parking facility at Mitchell Field, and ... we take care of our customers and their cars as if they were are own. We are not perfect, but we hope that if we should make a mistake, customers will trust that we will do whatever we can to make it right.5151 S Howell AveMilwaukee, WI US
Budget Rent A CarRead MoreLooking to get some body work done on your car? Beautify your ride with the experts at Budget Rent A Car in Milwaukee. At Budget Rent A Car, you can receive a quick routine oil change at a price you can afford. Budget Rent A Car's A+ team is prepared to help rid your car of any surface deficiencies when you ask them about their scratch and dent repair service. Budget Rent A Car offers tire changes and rotations to keep your vehicle in top shape. Looking to take care of some body work on your vehicle? Bring it in to the professionals at Budget Rent A Car today. Remember, Budget Rent A Car provides the best quotes on their services at their fantastic auto shop in Milwaukee. You'll definitely want to stop by before committing somewhere else.1921 S 108th StMilwaukee, WI US
Toya's Hair SalonRead MoreToya's Hair Salon in Milwaukee is a highly-rated hair salon with hairstylist experts available to meet your every need. Freshen up your look with a new 'do from this salon, a fashion-forward salon. For expert stylists with innovative visions, Toya's Hair Salon is just the place to go for your next haircut.6582 North 54th StreetMilwaukee, WI US
G R and B SalesRead MoreWhen the heat gets the best of you, water is more important than ever. Cool off no matter where you are with a bottle from G R and B Sales. Shop the great selection of vehicles including RVs and drive off the lot with a new and exciting ride. You can find parking easily in one of their many available spaces.105 N Oakridge DrNorth Prairie, WI US
Midwestern HelicopterRead MoreHaving honed his aviation skills in helicopter cockpits for 45+ years, the head pilot at Midwestern Helicopter leads a team of FAA–certified pilots in performing helicopter tours, charters, and pilot instruction. They steer a fleet of three Robinson R-44s and two R-22s over cityscapes and country vistas with photographers, pollinators, surveyors, or sightseers onboard, continuing a crash- and speeding-ticket-free record begun with the company's inception four years ago. The flight team acquaints new flyers with immediate actual flight experience during introductory flights and helps students to achieve private, commercial, and flight-instructor certification during FAA courses. As authorized merchants of Robinson aircraft, they can also hawk helicopters or perform maintenance on various models inside heated hangars without having to first notify the aircraft's next of kin.10450 52nd StKenosha, WI US


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Auto Repair in Eva
Our master mechanics identify the best auto repair shops in Eva. Edit search×
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Alabama comes to Landers McLarty Chevrolet for our large selection of quality new and used cars. Huntsville, AL locals, as well as Madison, Meridianville, New Hope, Decatur, and Birmingham residents rely on us when they need to find a vehicle to fit a budget. We're proud to be the automotive leader in our community. Since opening our doors, Landers McLarty Chevrolet has maintained a solid commitment to you, our customers, and offered the widest selection of automobiles with the highest level of customer satisfaction.
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My review
Town House®
Original recipe yields 8 servings
Based on a 2,000 calorie dietSee full nutrition
Ready In
I used a Whipped cream cheese and just folded the pepperoni into it, then put it back into a tupperware container and let it sit for a while. Though it was edible, it was bland. I think had I us...


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Respond to Review of Vegetable Dining Noka
by MariaPowell
Review: The food was 3.5 out of 5 pretty good really :) wasnt until i had to use toilet that there was a problem. No enter she said and walked away i used it anyway, second time no enter and she persisted and carted me upstairs to a smelly dirty toilet ... thumbs down. Not a way to treat your paying customers.
Posted by eatinggreen on Sunday, June 8, 2014
I severely doubt you interpreted that situation correctly - sounds like a classic case of the truth being lost in translation as culturally the Japanese do not act in this way towards gaijin, especially not in a legitimate establishment such as this.
Posted by MariaPowell on Sunday, June 8, 2014
Also a classic case of someone assuming the situation had to be something else. My japanese husband and friends were with me at the time. This happens alot in Japan Kobe and Kyoto the worst offenders. I was lucky enough to have japanese people to speak up for me.
Posted by eatinggreen on Tuesday, July 22, 2014
Hmm.. have to say I'm really surprised. In 11yrs in Japan I've never come across this sort of treatment, anywhere. We'll be in Kobe again next week, so I'll have to ask to use the toilet and see what they say!
Posted by MariaPowell on Tuesday, July 22, 2014
Yeah I know! But I have come across mixed groups some say that these things have never happened and some have had the worst experiences. I had a mixed bag of things this one being the worst. My husband spoke to the manager so I should think it wouldn't happen again. I HOPE!
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Between red carpets, swanky events, and IRL sightings, here are the best-dressed celebs of the week.
Off-Duty Style
Silk top with metallic beading and sequins, Roberto Cavalli, price on request, at Roberto Cavalli boutiques nationwide. Bikini bottom, Melissa Odabash, $175 (sold with bikini top). Silver cuff, Betony Vernon for Alexander Wang, $2,495.
Metallic coat, Alberta Ferretti, $2,740. Leather short overalls, Jeremy Scott, $1,600, at Opening Ceremony, NYC, L.A. Crystal necklace, $1,441, crystal ring, $228, both, Atelier Swarovski by Mary Katrantzou.
Oh, Pioneers!


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The Andelman Brothers invite you to America's most beloved Drive-in
Movies Fri-Sat-Sun | 'Rocky Horror' Sat Night
((The Mendon Flea Market will return Spring 2015))
Mendon Flea Market
Antiques, collectibles, household items & food market!
Saturdays 7AM- 2PM (weather permitting)
Free Admission for shoppers!
Free Parking!
Contact for vendors - Gary Sohmers
Gary Sohmers appeared as an appraiser for 13 seasons on the PBS television program "Antiques Roadshow."
Vendors Load In - 6:00 am
October Vendor Space 20 x 16 = Only $10
Vendors must vacate and leave a clean space by 3:00 pm or will not be allowed to return.
Upcoming Events
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Rocky Horror Night!
Rocky Horror Night!
Sat Oct 17 @ 2:00PM - 05:00PM
Phantom Gourmet Wine Country
Phantom Gourmet Wine Country


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The most famous screen siren of our time knew very well that 'diamonds are a girls best friend'. She may have had to rely on gentlemen who prefer blondes to get hers, but you can simply turn to this deal from Diamonds Hair and Beauty Studio.
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Calendar of Events
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Continuing series this week:
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PSYCHICS/HEALERS available Tue-Sat 11am-7pm and Sun noon-5! Please call 818.985.2010 for availability and to book an appointment. Readings are also available by phone and Skype.
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Miller, RJ and Ainsworth, RW (1996) An ultra-high speed traverse system for fast response aerodynamic measurements in transonic flow facilities. In: 13th Symposium on Measuring techniques for transonic and supersonic flow in cascades and turbomachines, 1996-9-5 to 1996-9-6, Zurich, Switzerland.Full text not available from this repository.
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Need a website? Creating one is fast, easy and affordable. Follow the steps below (or start here) and you'll see how simple the process truly is.
Register a Domain Name
Branding your site and name is important. Before you select a domain name, make sure it is also available on various social media platforms (Twitter, YouTube, etc.) Also, choose a name that is memorable and easy to spell.
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why you should never use free hosts
I am often asked about creating free websites. Sorry, but I won't ever recommend this unless it's a temporary or test site.
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Located in the Financial District of Boston, 2 Oliver Street is an eleven floor, 270,302-sf office building overlooking Post Office Square. Occupancy is slated for the fall of 2012.
Founded in 1992 by former Commissioner of Energy Resources for the Commonwealth of Massachusetts Paul Gromer, Peregrine Energy Group, Inc. is an energy consulting firm with a unique expertise in data visualization. They offer a deep knowledge of energy efficiency and renewable energy and a passion for making energy information easy to understand, use, and share with others.
"Boston's focus on advancing technology has created an ideal atmosphere for renewable energy firms to flourish and Avison Young looks forward to helping other firms locate in the area," said McFarland.
About Avison Young
Founded in 1978, Avison Young is Canada's largest independently-


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Idea Capital pools resources from throughout the arts community to provide direct monetary support for Atlanta artists, performers and cultural producers. The more tax-deductible donations we receive, the more grants we can award. In our first five years, we have made 42 grants totaling over $40,000 to artists working in diverse disciplines. We can only grant what you give.
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|Sweet Tea: Documenting the Queer South: book compilation about Atlanta drag scene
|Stephanie Pharr, Onur Topal-Sumer, and Martha Whittington
|hymHouse: exhibition paying homage to Judy Chicago's
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|Airplanes: paper airplanes made by US prisoners
Click the button below to make your 2015 contribution via our fiscal agent, Alternate Roots.
Amy Pursifull & Santiago Paramo
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21 Jump Street is the headquarters for a squad of police officers who specialize in investigations relating to young people. Each of the Jump St. personnel was selected for their ability to pass for high school or college students, allowing them to operat
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The main reason I wanted this season, is because I love the episodes Loc'd Out pt 1 & 2.
and it continues and finishes up in season 4 with "Booker's " exit to... Read more
it has been years the show is still great i m only on season 2 but only 2 more and season 3 here i come now i need season 4 to come in ! got it fast and packed very well. Read morePublished 2 months ago by joyce kozachenko
Get and enjoy all the 21 Jump Street seasons, even if you have seen them before. Johnny Depp is at his best in this series! Thanks!Published 15 months ago by Bronco Linda
The show is great the first three seasons. I think it goes downhill the next few seasons because johnny depp is not there. I highly recommend this show for even just the nostalgia.Published 17 months ago by the repeller
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|Publication number
|Publication type
|Application number
|Publication date
|Jun 20, 2000
|Filing date
|Jun 4, 1998
|Priority date
|Jun 4, 1997
|Fee status
|Publication number
|Cato Laurencin, Harry Allcock, Sobrasua Ibim, Archel Ambrosio, Michael Kwon
|Original Assignee
|The Penn State Research Foundation
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (6), Non-Patent Citations (32), Referenced by (41), Classifications (35), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
The U.S. Government has certain rights by virtue of NIH Grant No. AR41972 to Cato Laurencin.
Priority is claimed to U.S. Provisional Application Ser. No. 60/048,523, filed Jun. 4, 1997.
This invention is generally in the field of polymer blends, interpenetrating networks (IPN) of polymers, and semi-interpenetrating networks (semi-IPNs) of polymers, specifically those including polyphosphazene, for use in controlled degradation applications, such as biomedical applications.
The ability to regulate the rate and extent of degradation of a material is critical in many environmental and biomedical applications. In recent years, major research efforts have been directed towards the development of biodegradable materials for biomedical applications such as controlled drug delivery and tissue regeneration. The field of controlled drug delivery has evolved in an effort to overcome the many limitations of traditional drug delivery. Conventional parenteral drug delivery relies on repeated injection or infusion via different routes to achieve tissue levels of desired drugs. Consequently, patient compliance can be unsatisfactory. Waldvogel, in Orthopaedic Infection, Springer-Verlag: New York (1988) pp. 1-8. In addition, repeated injection or infusion leads to high serum levels of the drug, thus posing serious toxicity risks to otherwise healthy organ systems. Furthermore, wastage and costs can be considerable, because a substantial amount of the drug does not reach the target site.
By the 1950's technology had developed to successfully administer drugs at controlled rates using polymeric devices as the drug carriers. Laurencin and Langer, Clinics in Lab. Med. 7:301 (1987). Biodegradable, biocompatible matrices for controlled drug delivery provide many benefits. First, patient compliance is enhanced due to less frequent drug administration. Second, the risk of drug concentrations reaching toxic levels is minimized since the drug is released at controlled rates. Third, the cost of treatment is considerably reduced, because a smaller amount of drug can be used. Finally, in cases where the delivery device is surgically implanted, the need for a second surgical procedure in order to remove the drug-depleted device is obviated.
While biodegradable polymers, such as poly(lactide-co-glycolide) (PLGA), are useful in drug delivery and tissue regeneration applications since they degrade into harmless substances, drawbacks--primarily that they degrade by bulk erosion--limit their application. These polymers do not allow for release of a substance as controllable as is desired in certain controlled drug delivery applications. Since polymers of lactic and glycolic acids and their copolymers (PLGA) degrade quickly in the body into non-toxic products, PLGA is used for biodegradable sutures and can potentially be used in implantable screws, intravascular stents, pins, drug delivery devices, and as a temporary scaffold for tissue and bone repair. Additionally, PLGA has good mechanical properties which improve the structural integrity of such devices. However, since PLGA degrades completely by bulk erosion, it loses more than 50% of its mechanical strength in less than two months, which can lead to uncontrollable release rates of drugs and can develop biocompatibility problems (probably due to an accumulation of lactic and glycolic acids during degradation).
Other applications are also dependent on the rate and extent of degradation. For example, plastic medical devices, food containers, bottles, bags, and other materials currently in use create an extensive, expensive waste disposal problem. It is therefore highly desirable to create biodegradable materials that retain sufficient mechanical strength over the desired time period, but which degrade when no longer useful.
Accordingly, it is an object of this invention to provide biodegradable polymer mixtures for use in biomedical and environmental applications.
It is another object of this invention to provide biodegradable polymeric matrices which degrade by surface erosion.
It is another object of this invention to provide biodegradable polymeric matrices for which one can modulate the degradation rate.
It is another object of this invention to provide biodegradable polymeric matrices with a sufficient degree of flexibility to facilitate molding of the polymeric matrix.
It is another object of this invention to provide biodegradable, biocompatible polymeric matrices for controlled drug delivery and bone repair applications.
It is another object of this invention to provide biodegradable, biocompatible polymeric matrices with good osteoconductivity to aid in drug delivery to sites within bone.
It is another object of this invention to provide biodegradable polymeric matrices which degrade by bulk erosion for environmental uses.
Biodegradable polymeric compositions are formed by combining biodegradable polyphosphazenes and at least one other polymer, either in the form of a blend, a semi-interpenetrating network (semi-IPN), or an IPN. The side groups and composition of the polyphosphazenes are used to determine the properties of the compositions, for example, the rate and extent of degradation, and mechanical properties. These compositions are useful in biomedical applications, including controlled drug delivery and tissue regeneration, and environmental applications.
In the most preferred embodiment, as demonstrated by the examples, the polyphosphazenes contain hydrophobic side groups, such as p-methylphenoxy and other aromatic groups, and groups which impart hydrolytic instability, such as amino acid alkyl esters, and degrade by surface erosion. A preferred example is ethyl glycinato-substituted polyphosphazene (PPHOS) with p-methylphenoxy as co-substituent. These polyphosphazenes are blended with other polymers, such as PLGA, which has desirable mechanical properties but which degrades by bulk erosion, so that the blend degrades by surface erosion. Any polymer which degrades by bulk or surface erosion can be used. However, for the biomedical applications, FDA approved polymers, such as polymers of lactic and glycolic acids and their copolymers, are preferred.
The compositions have essentially two main components: one or more biodegradable polyphosphazenes and one or more other polymers. Additional components, depending on the application for which the composition is intended, include drugs, imaging agents, cells, coatings, pore forming agents, plasticizers, and cross-linkers. The compositions are typically formed by blending. Semi-IPNs or IPNs may then be formed by crosslinking, using standard techniques. The polyphosphazenes can be tailored to be compatible with, or alter the properties of, a wide variety of polymers by changing the side groups. A polyphosphazene with hydrophobic side groups and side groups that impart hydrolytic instability can be mixed with a polymer which degrades by bulk or surface erosion to yield a polymer which degrades by surface erosion. Alternately, the polyphosphazene may have a side group which is both hydrophobic and imparts hydrolytic instability to acheive the same result. Such mixtures are useful in biomedical and environmental applications which require controlled degradation rates.
The term "miscible blend" as used herein describes a blend which exhibits a single glass transition temperature (Tg). These blends do not undergo phase separation.
The term "polyphosphazene" as used herein describes a polymer with a backbone consisting of nitrogen and phosphorus separated by alternating single and double bonds. Each phosphorus atom is covalently bonded with two side chains ("R"). The repeat unit has the general structure of (1): ##STR1## wherein n is an integer.
The term "surface erodible" as used herein describes any material which degrades uniformly from the surface of the material, and therefore substantially maintains its original shape throughout the degradation process.
The term "bulk erodible" as used herein describes any material which degrades throughout the bulk of the material (i.e. at the surface and within its interior), to therefore permit or cause the material to collapse, or fall apart, following partial degradation.
Biodegradable polymers are those that have a half life under physiological conditions of between about two hours and one year.
Non-biodegradable polymers are those that have a half life longer than approximately one year under physiological conditions.
Interpenetrating networks (IPNs) are matrices containing two polymers in which each of the polymers is crosslinked to itself or in which the polymers are crosslinked to each other.
Semi-interpenetrating networks (semi-IPNs) are matrices containing two polymers in which only one of the polymers is crosslinked. These matrices can be formed by swelling a crosslinked polymer with a monomer of a second polymer and then polymerizing the second polymer.
Polyphosphazenes are high molecular weight polymers with an inorganic backbone of alternating phosphorus and nitrogen atoms with two side groups on each phosphorus atom. Polymers with a wide range of properties can be synthesized from this polymer backbone by incorporating different side groups, by varying the side group in single-substituent polyphosphazenes, and/or by using two or more co-substituents. Individual polyphosphazenes may be hydrophobic, amphiphilic, or hydrophilic; water-stable or water-erodible; crystalline or amorphus; bioinert or bioactive. The hydrophobicity of the polyphosphazene is increased by adding hydrophobic side groups, such as aromatic groups, to the backbone. One can regulate the degradation rate by increasing the hydrophobicity of the polyphosphazene.
Examples of polyphosphazenes which degrade by surface erosion and which can be used to make the desired blends contain hydrophobic side groups and groups which impart hydrolytic instability. The hydrophobic side groups include, but are not limited to, aromatic groups, such as p-methylphenoxy. Side groups that impart hydrolytic instability include, but are not limited to, amino acid alkyl esters.
For example, the hydrophobicity of an ethyl glycinato-substituted polyphosphazene (PPHOS) is increased by adding p-methylphenoxy as co-substituent. The ethyl glycinato side group imparts biodegradability to the molecule. This molecule degrades in aqueous environments to produce innocuous products. PPHOS has been found to support the adhesion and growth of osteoblast-like cells, a beneficial property for bone repair applications. Laurencin, et al., J. Biomed. Mater. Res. 27:963 (1993).
Miscible blends within the same class of polyphosphazenes are described in U.S. Pat. Nos. 4,005,520 and 4,073,824 to Dieck, et al. These systems are limited to mixtures within the same family of polyphosphazenes. However, they could be mixed with other polymers as described herein. Miscible blends of etheric polyphosphazenes and polymers bearing acidic functional groups are described in U.S. Pat. No. 5,250,626 to Landry, et al. However these blends are not biodegradable and therefore are not suitable for biomedical nor environmental applications.
Biodegradable or non-biodegradable polymers can be used. Polymers which degrade by either bulk or surface erosion can be used. Mixtures of these polymers can be mixed with polyphosphazene. For biomedical applications, polymers which have received FDA approval, such as polylactide, polyglycolide, and blends and copolymers thereof are preferred.
For medical applications, it is preferable that the polymer degrades after the treatment period ends. The degradation products of the polymer in these medical applications should have a sufficiently low molecular weight to allow excretion. A low initial molecular weight of the polymer should aid in blend formation.
Hydrophobic polymers are well known to those of skill in the art. Examples of hydrophobic biodegradable polymers include polyanhydrides, polyorthoesters, polyhydroxy acids, polydioxanones, polycarbonates, and polyaminocarbonates. Examples of hydrophobic non-biodegradable polymers include polyethylene, polypropylene, poly(acrylic acid), poly(methacrylic acid), and some polyesters.
Examples of hydrophilic non-biodegradable polymers include poly(ethylene glycol), poly(ethylene oxide), partially or fully hydrolyzed poly(vinyl alcohol), poly(ethylene oxide)-co-poly(propylene oxide) block copolymers (poloxamers and meroxapols), poloxamines, carboxymethyl cellulose, and hydroxyalkylated celluloses such as hydroxyethyl cellulose and methylhydroxypropyl cellulose, and natural polymers such as polypeptides, polysaccharides or carbohydrates such as Ficoll� polysucrose, hyaluronic acid, dextran, heparan sulfate, chondroitin sulfate, heparin, or alginate, and proteins such as gelatin, collagen, albumin, or ovalbumin or copolymers or blends thereof. As used herein, "celluloses" includes cellulose and derivatives of the types described above; "dextran" includes dextran and similar derivatives thereof.
The polymers must have crosslinkable groups to form IPNs. Suitable polymerizable groups include ethylenically unsaturated groups (i.e., vinyl groups) such as vinyl ethers, allyl groups, unsaturated monocarboxylic acids, unsaturated dicarboxylic acids, and unsaturated tricarboxylic acids. Unsaturated monocarboxylic acids include acrylic acid, methacrylic acid and crotonic acid. Unsaturated dicarboxylic acids include maleic, fumaric, itaconic, mesaconic or citraconic acid. The preferred polymerizable groups are acrylates, diacrylates, oligoacrylates, dimethacrylates, oligomethacrylates, and other biologically acceptable photopolymerizable groups. (Meth)acrylates are the most preferred active species polymerizable group. These functional groups can be present on the polymers, or added as monomers to the polymer mixture.
Methods for the synthesis of these polymers are well known to those skilled in the art. See, for example, Concise Encyclopedia of Polymer Science and Polymeric Amines and Ammonium Salts, E. Goethals, editor (Pergamen Press, Elmsford, N.Y. 1980). Many polymers, such as PLGA and poly(acrylic acid), are commercially available. Naturally occurring and synthetic polymers may be modified using chemical reactions available in the art and described, for example, in March, "Advanced Organic Chemistry," 4th ed., Wiley-Interscience Publication, New York (1992).
Blends can be formed by co-dissolving the polymers in a solvent, by melting and mixing the two polymers, or other standard techniques. The polymers can be dissolved in a solvent that does not adversely affect or react with the polymers or any material or particles to be suspended in the solution. The relative amount of solvent will have a minimal effect on the structure of the polymer blend, but will affect the solvent evaporation time.
Solvents should be non-reactive with the components of the composition. It is preferable that no protic solvents are used since hydrolyzable linkages are present. Halogenated solvents may be used in those embodiments where the composition is polymerized ex vivo, or where the solvents can be effectively removed prior to implanting the articles. It is preferred to use solvents which are non-toxic for in vivo applications. Suitable solvents for these applications include glyme, dimethylsulfoxide (DMSO) and other polar aprotic solvents.
A solution or dispersion of the polymer mixture can be cast, extruded or injected into any appropriate mold. The solvent is then evaporated from the composition over a period of time, for example, 24 hours at room temperature. Any residual solvent can be subsequently removed by lyophilization.
Polymers can be blended in any ratio which yields the desired properties. This ratio can range from 1 to 99, polyphosphazene to polymer, to 99 to 1, polyphosphazene to polymer. A more preferred ratio is 25:75, polyphosphazene to other polymer.
Interpenetrating networks are formed by crosslinking some or all of the polymers in the mixture. This can be used to impart additional stability.
The polymers can be polymerized using any suitable free-radical initiators (active species), for example, photoinitiators and thermally activatable initiators (preferably in a concentration not toxic to cells, less than 1% by weight, more preferably between 0.05 and 0.01% by weight percent initiator). The polymers form semi-interpenetrating polymer networks when crosslinked.
The compositions can be polymerized ex vivo to provide solid articles, such as pins and screws, which can be used to repair bones. Alternatively, the compositions can be polymerized in situ to function as a bone cement. For those areas which can be accessed via injection, the composition is preferably fluid when applied, and solid when polymerized.
"Electromagnetic Radiation", as used herein, refers to energy waves of the electromagnetic spectrum including, but not limited to, x-ray, ultraviolet, visible, infrared, far infrared, microwave, and radio-frequency, and can be used to crosslink the polymers.
"Visible light" refers to energy waves having a wavelength of at least approximately 4.0�10-5 cm. "Ultraviolet light" refers to energy waves having a wavelength of at least approximately 1.0�10-5 cm but less than 7.0�10-5 cm. "Blue light" as used herein refers to energy waves having a wavelength of at least approximately 4.5�10-5 cm but less than 4.9�10-5 cm. The polymers can be crosslinked by exposure to a radiation source, such as lamps, the sun, blue lamps, and ultraviolet lamps.
Suitable thermally activatable initiators include various peroxides and azobisisobutyronitrile (AIBN). Suitable photoinitiators include those photoinitiators that are capable of crosslinking the composition upon exposure to light equivalent to between 0.01 mW/cm2 and 1 Watt/cm2. A minimum of 0.01 mW/cm2 intensity is needed to induce polymerization. Maximum light intensity can range from one to 1000 mW/cm2, depending upon the wavelength of radiation. Photoinitiators that generate an active species on exposure to UV light are well known to those of skill in the art.
Tissues can be exposed to higher light intensities, for example, longer wavelength visible light, which causes less tissue/cell damage than shortwave UV light. In dental applications, blue light (470-490 nm) is used at intensities of 100 to 400 mW/cm2 clinically.
Preferably, when the crosslinking occurs in vivo, the polymerization conditions are mild enough not to damage surrounding tissue. Although discussed herein principally with regard to administration of a light source external to the skin, this should be interpreted as equally applicable to light applied through tissues, for example, from a catheter in a blood vessel adjacent to where the composition has been injected, or in the space adjacent to a bone to be repaired. The depth of penetration can be controlled by the wavelength of the light used to cause the photopolymerization. For example, visible light penetrates deeper through tissue than UV light. Penetration through tissue can range from microns to one cm, with one cm occurring with visible light. In a preferred embodiment, radiation with a wavelength between 200 and 700 nm is used to create active species and polymerize the network.
The polymerizable groups in the composition can be polymerized using photoinitiators that generate active species upon exposure to UV light, or, preferably, using long-wavelength ultraviolet light (LWUV) or visible light, for example, by photon absorption of certain dyes and chemical compounds. LWUV and visible light are preferred because they cause less damage to tissue and other biological materials than UV light. Useful photoinitiators are those which can be used to initiate polymerization of the macromers without cytotoxicity and within a short time frame, minutes at most and most preferably seconds.
Exposure of dyes and cocatalysts such as amines to visible or LWUV light can generate active species. Light absorption by the dye causes the dye to assume a triplet state, and the triplet state subsequently reacts with the amine to form an active species which initiates polymerization. Polymerization can be initiated by irradiation with light at a wavelength of between about 200-700 nm, most preferably in the long wavelength ultraviolet range or visible range, 320 nm or higher, and most preferably between about 365 and 514 nm.
Numerous dyes can be used for photopolymerization. Suitable dyes are well known to those of skill in the art. Preferred dyes include erythrosin, phloxime, rose bengal, thonine, camphorquinone, ethyl eosin, eosin, methylene blue, riboflavin, 2,2-dimethyl-2-phenylacetophenone, 2-methoxy-2-phenylacetophenone, 2,2-dimethoxy-2-phenyl acetophenone, other acetophenone derivatives, and camphorquinone. Suitable cocatalysts include amines such as N-methyl diethanolamine, N,N-dimethyl benzylamine, triethanol amine, triethylamine, dibenzyl amine, N-benzylethanolamine, N-isopropyl benzylamine. Triethanolamine is a preferred cocatalyst.
A number of different additives can be added to the blend during formation.
Porosity Forming Agents
The polymer mixtures can also include various inorganic or volatile salts and/or proteinaceous materials, such as gelatin, which dissolve at a relatively faster rate under physiological conditions than the composition. The removal of these particles creates pores in the polymer mixture. The materials can be selected to have a desired size or size distribution, and can be evenly distributed throughout the composition to provide controlled porosity.
Suitable materials include particles of salts. For tissue engineering devices, the particles can be any salt that forms crystals or particles having a diameter of approximately 100 to 250 microns, which is easily removed from and does not react with the polymer, and is non-toxic if some residue remains in the polymer after leaching. Micro- or nano-particles of degradable polymer can also be used to provide porosity, if they degrade at a faster rate than the blend or crosslinked composition. Examples of other porosity forming agents include proteins such as gelatin and agarose, starches, polysaccharides such as alginate and other polymers. Preferably, the salt is a sodium salt, such as sodium chloride, sodium tartrate and sodium citrate, and other water soluble salts not soluble in the polymer solvent, for example, tetrahydrofuran. The most preferred salt is sodium chloride. Preferably, the particles are first sieved through a mesh or a series of screens to provide particles of relatively uniform diameter. The particles are then added to the composition. The initial weight fraction of porosity forming agents is preferably between 0.02 and 0.9 dry weight percent. The initial weight fraction is instrumental in determining the characteristics of the semi-interpenetrating polymer matrix.
A particulate leaching process can be used to create a porous polymeric matrix. In one embodiment, salt particles are suspended in the polymer blend, the solvent is removed, and the particles are leached out of the hardened polymer. When hydrolytically unstable groups are present, it is preferable to avoid using aqueous solutions to remove salts to create porosity.
Removal of the particles will create a polymer matrix having a plurality of relatively evenly spaced interconnected interstitial spaces or pores, formerly occupied by the particle crystals, into which cells can migrate, attach, and proliferate, or into which drugs can be dispersed. The porosity of the matrix can be very high, typically between 60 and 90%, depending on the amount of incorporated particles. Preferrably, the pores in the composition can have a pore size in the range of between approximately 100 and 250 microns, by appropriate selection of the size of the leachable particles.
An interconnecting pore network is described by H. R. Allcock, et al., "Synthesis of poly[(amino acid alkyl ester) phosphazenes]," Macromolecules, 10, 824-830 (1977); H. R. Allcock, et al., "Hydrolysis pathways for aminophosphazenes," Inorg. Chem., 21, 515-521 (1982); and Eggli, P. S., et al., "Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancerous bone of rabbits", Clin. Orthop., 232, 127-138 (1987). Such a network facilitates the invasion of cells and promotes an organized growth of the incoming cells and tissue. The polymer described by Allcock, et al. can be replaced with the polymer mixtures described herein. The porosity has been demonstrated to influence the biocompatibility and bony integration on various porous material. White and Shors, "Biomaterial aspects of Interpore 200 porous hydroxyapatite", Dental Clinical of N. Amer., 30, 49-67 (1986). Klaitwatter, et al., "Application of porous ceramics for the attachment of load bearing orthopedic applications", J. Biomed. Mater. Res. Symp., 2, 161 (1971) shows that a pore size of over a 100 μm is suitable and necessary for regenerating cells and bony ingrowth.
The compositions can also include particles of excipients, for example, ceramics. Specific excipients include hydroxyapatite, plaster of paris, calcium carbonate, tricalcium phosphate, polyphosphates, polyphosphonates, and polyphosphites.
Therapeutic Agents
The compositions can also include various therapeutic and/or diagnostic agents. The agents can be incorporated in the composition directly, or can be incorporated in microparticles which are then incorporated into the composition. Incorporating the agents in microparticles can be advantageous for those agents which are reactive with one or more of the components of the composition, i.e. agents which have hydroxy or amine functionality which are incorporated into compositions including anhydride linkages. Microparticles, and methods of preparation thereof, are well known to those of skill in the art.
Examples of therapeutic agents which can be incorporated into the compositions include proteins, polysaccharides, nucleic acid molecules, and synthetic organic or inorganic molecules. Proteins are defined as consisting of 100 amino acid residues or more; peptides are less than 100 amino acid residues. Unless otherwise stated, the term protein refers to both proteins and peptides. Examples include insulin and other hormones. Polysaccharides, such as heparin, can also be administered. Compounds with a wide range of molecular weight, for example, between 50 and 500,000 grams per mole, can be incorporated into the composition. These may be useful for therapeutic or diagnostic purposes. Nucleic acid molecules include genes, antisense molecules which bind to complementary DNA to inhibit transcription, ribozymes and ribozyme guide sequences. Drugs which can be used include anaesthetics, antibiotics, antivirals, genes, chemotherapeutic agents, anti-angiogenic agents, hormones, drugs having an effect on vascular flow, growth factors, and anti-inflammatories.
The compositions can be combined with humoral factors to promote cell transplantation and engraftment. For example, the compositions can be combined with angiogenic factors, antibiotics, anti-inflammatories, growth factors, compounds which induce differentiation, and other factors which are known to those skilled in the art of cell culture.
Diagnostic Agents
Any of a variety of diagnostic agents can be incorporated within the compositions, which can locally or systemically deliver the incorporated agents following administration to a patient. Imaging agents can be used which allow one to monitor bone repair following implantation of the compositions in a patient. Suitable imaging agents include commercially available agents used in positron emission tomography (PET), computer assisted tomography (CAT), single photon emission computerized tomography, x-ray, fluoroscopy, and magnetic resonance imaging (MRI).
Examples of suitable materials for use as contrast agents in MRI include the gadolinium chelates currently available, such as diethylene triamine pentaacetic acid (DTPA) and gadopentotate dimeglumine, as well as iron, magnesium, manganese, copper, and chromium.
Examples of materials useful for CAT and x-rays include iodine based materials, such as ionic monomers typified by diatrizoate and iothalamate, non-ionic monomers such as iopamidol, isohexol, and ioversol, non-ionic dimers, such as iotrol and iodixanol, and ionic dimers, for example, ioxagalte.
Air and other gases can be incorporated for use in ultrasound imaging. These agents can be detected using standard techniques available in the art and commercially available equipment.
Successful design of an implant to replace skeletal tissue requires knowledge of the structure and mechanical properties of bone and an understanding of the means by which grafts become incorporated into the body. This information can then be used to define desirable characteristics of the implant to ensure that the graft functions in a manner comparable to organic tissue. A graft may be necessary when bone fails and does not repair itself in the normal amount of time or when bone loss occurs through injury or cancer. Bone grafts must serve a dual function: to provide mechanical stability and to be a matrix or environment for osteogenesis. Since skeletal injuries are repaired by the regeneration of bone rather than by the formation of scar tissue, grafting is a viable means of promoting healing of osseous defects, as reviewed by Friedlaender, G. E., "Current Concepts Review: Bone Grafts," J. of Bone and Joint Surgery, 69A(5), 786-90 (1987). Osteoinduction and osteoconduction are two mechanisms by which a graft may stimulate the growth of new bone. In the former case, inductive signals lead to the phenotypic conversion of connective tissue cells to bone cells. In the latter, the implant provides a scaffold for bony ingrowth.
The bone remodeling cycle is a continuous event involving the resorption of pre-existing bone by osteoclasts and the formation of new bone by the work of osteoblasts. Normally, these two phases are synchronous and bone mass remains constant. However, the processes become uncoupled when bone defects heal and grafts are incorporated. Osteoclasts resorb the graft, a process which may take months. More porous grafts revascularize more quickly and graft resorption is more complete. Bone formation begins after the graft has been resorbed. Bone mass and mechanical strength return to near normal.
Synthetic implants formed of the polymeric mixtures described herein may obviate many of the problems associated with organic grafts. Further, synthetics can be produced in a variety of stock shapes and sizes, enabling the surgeon to select implants as his needs dictate, as described by Coombes, A. D. A. and J. D. Heckman, "Gel Casting of Resorbable Polymers: Processing and Applications," Biomaterials, 13(4):217-24 (1992). Metals, calcium phosphate ceramics and polymers have all been used in grafting applications.
The polymeric matrices can be designed for use in types of organ or tissue implantation or regeneration, other than bone, including growth and/or implantation of nerve cells, muscle, bone, cartilage or tendon, and mesenchymal (cells having a metabolic function, such as liver, intestine, pancreatic, etc) cells.
The matrix described here is implanted using standard surgical technique. The matrix can be directly implanted into the site where growth is desired. In the preferred embodiment, the matrix will be pre-cast into a desired shape.
It is preferable for certain applications, for example when the composition is polymerized or solidified in situ, for the composition to be fluid enough to be injectable. Following injection into a site in a patient, the composition can be crosslinked and/or solvent removed to form a solid polymer network.
The composition can be used as a bulking agent for hard tissue defects, such as bone or cartilage defects. Examples include injection of the composition into the area surrounding the skull where a bony deformity exists secondary to trauma, or, in the case of complex fractures of long bones, such as the femur or tibia, injection or implantation into the bone or area of bone loss or fragmentation. The composition can also be used in reconstructive surgery.
For use in dental applications, the viscosity of the composition is preferably thick, or paste-like, such that it can be applied to the surface of a broken tooth such that the composition will maintain a desired shape, and will harden when solvent is removed or when the mixture polymerized. The viscosity can be adjusted by adding appropriate viscosity modifying agents.
The present invention will be further understood by reference to the following non-limiting examples.
The mutual solvent approach was used to make cohesive miscible blends which retain the desirable properties of both parent polymers. Dobry and Boyer-Kawenoki, "The mutual solvent approach", J. Polymer Sci., 2:90-97 (1947). A polymer was synthesized by blending PLGA and PPHOS to yield a compositions with the beneficial features of its components: PLGA's biocompatibility and widespread applicability and PPHOS's hydrophobicity.
Synthesis of Ethyl Glycinato-substituted Polyphosphazenes (PPHOS)
Polyphosphazenes are formed by reacting poly(dichlorophosphazene) with the appropriate side chain nucleophiles, which displace the chlorines. Poly[(25% ethyl glycinato)(75% p-methylphenoxy) phosphazene] (PPHOS-25), poly[(50% ethyl glycinato)(50% p-methylphenoxy) phosphazene] (PPHOS-50) and poly[(75% ethyl glycinato)(25% p-methylphenoxy) phosphazene] (PPHOS-75) were synthesized according to a procedure reported by Laurencin, et al., Use of polyphosphazenes for skeletal tissue regeneration. J. Biomed. Mater. Res., 1993, 27, 963-73. Briefly, poly(dichlorophosphazene) was allowed to react with sodium p-methylphenoxide in order to replace 75%, 50% or 25% of the chlorine atoms. The partially substituted polyphosphazenes were then allowed to react with a large excess of ethyl glycinate to replace the remaining chlorine atoms and obtain the fully substituted polyphosphazenes. The polyphosphazenes were purified by repeated precipitations in heptane (five times) followed by centrifugation in order to remove residual salts. The polyphosphazenes were dried under vacuum and stored under argon prior to use.
Fabrication of Blend
Blend A (PLGA/PPHOS-25), Blend B (PLGA/PPHOS-50) and Blend C (PLGA/PPHOS-75) were fabricated using the mutual solvent approach. First, 0.5 g of PLGA and 0.5 g of PPHOS were blended in glass scintillation vials containing 10 mL of chloroform and mixed vigorously for 24 h until dissolved. Following dissolution and further vortexing for another 4 h, the solutions were allowed to stand at room temperature for at least 48 h to ensure that no phase separation occurred prior to casting the mixture. The mixtures were then poured into a plastic petri dish lined with Bytac TEFLON™ paper and air dried for 24 h. The blends were dried further by lyophilization (Labconco 12, Kansas City, Kans. USA) for at least 24 h and stored at -20� C. until used.
Miscibility of Blend
The miscibility of two different polymers in polymer blends is generally a result of strong intermolecular interactions between the polymers. These interactions include hydrogen bonding, dipole-dipole interactions, and van der Waals forces. Sometimes, the miscibility of polymers may be due mainly to entropic effects. In the case of PLGA and PPHOS polymers, their miscibility can probably be attributed to the presence of similar functional groups (ester groups) on both types of polymers which can enhance the intermolecular interactions (dipole-dipole and van der Waals) between the polymers. Additionally, strong hydrogen bonding can occur between the amino groups of the PPHOS polymers and the ester groups of PLGA.
The miscibility of the PPHOS/PLGA blend was determined by measuring the glass transition temperature (Tg) through differential scanning calorimetry (DSC), analyzing the surface characteristics using scanning electron microscopy (SEM), and measuring the degradation rates over a two week period. Each of the blends had a single glass transition temperature between the glass transition temperatures of their respective parent polymers. The surface analysis, using SEM, demonstrated that the blends have smooth, uniform surfaces. Additionally, the degradation studies showed near-zero order degradation kinetics for each of the blends, where Blends A and B lost 10% of their mass after 2 weeks, while Blends C lost 30% of its mass during the same time period.
The teachings of the cited publications are indicative of the level of skill and the general knowledge of those of skill in the art. To the extent necessary, the publications are specifically incorporated herein by reference. Modifications and variations of the present invention will be obvious to those skilled in the art from the foregoing detailed description and are intended to be encompassed by the following claims.
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|Cross-linked bioactive hydrogel matrices
|Mar 11, 2013
|Feb 17, 2015
|Pioneer Surgical Technology, Inc.
|Bone implant materials comprising cross-linked bioactive hydrogel matrices
|Sep 25, 2008
|Jul 14, 2015
|Celonova Biosciences, Inc.
|Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
|Oct 26, 2007
|Aug 18, 2015
|Celonova Biosciences, Inc.
|Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
|Oct 24, 2007
|Aug 25, 2015
|Celonova Biosciences, Inc.
|Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
|Aug 13, 2003
|May 6, 2004
|Medtronic, Inc.
|Active agent delivery systems, medical devices, and methods
|Jan 11, 2002
|May 20, 2004
|Michael Grunze
|Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a microstructured surface
|Aug 13, 2003
|Jun 17, 2004
|Medtronic, Inc.
|Active agent delivery system including a hydrophobic cellulose derivative, medical device, and method
|May 10, 2004
|Nov 18, 2004
|Medtronic, Inc.
|Moisture curable materials for delivery of agents, methods, and medical devices
|Aug 11, 2004
|Mar 24, 2005
|Dinh Thomas Q.
|Active agent delivery systems including a miscible polymer blend, medical devices, and methods
|Aug 11, 2004
|Mar 24, 2005
|Dinh Thomas Q.
|Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods
|Jan 16, 2002
|Apr 7, 2005
|D'eredita Riccardo
|Biodegradable auricular prosthetic device
|Feb 20, 2003
|May 19, 2005
|Knothe Tate Melissa L.
|Composition and method for inducing bone growth and healing
|Sep 10, 2004
|May 26, 2005
|Laurencin Cato T.
|Polymeric nanofibers for tissue engineering and drug delivery
|Dec 5, 2003
|Mar 9, 2006
|Hiromu Ohnogi
|Sep 26, 2005
|Mar 30, 2006
|Polyzenix Gmbh
|Coated dental implants
|Oct 28, 2005
|May 4, 2006
|Cima Michael J
|Orthopedic and dental implant devices providing controlled drug delivery
|Dec 22, 2005
|Jul 6, 2006
|Dewitt David M
|Biodegradable coating compositions including multiple layers
|Dec 22, 2005
|Sep 7, 2006
|Dewitt David M
|Biodegradable coating compositions comprising blends
|May 4, 2006
|Jan 18, 2007
|Microchips, Inc.
|Medical and dental implant devices for controlled drug delivery
|Mar 19, 2001
|May 21, 2003
|Polyzenix GmbH
|Dental implants having bacterial resistance
|Mar 19, 2001
|Sep 27, 2001
|Michael Grunze
|Polyphosphazene derivatives
|Nov 26, 2002
|Jun 5, 2003
|Parallel Solutions Inc
|Copolymer libraries and production and use thereof
|Feb 20, 2003
|Aug 28, 2003
|Cleveland Clinic Foundation
|Composition and method for inducing bone growth and healing
|Aug 13, 2003
|Feb 19, 2004
|Medtronic Inc
|Active agent delivery system including a hydrophobic cellulose derivate
|May 10, 2004
|Nov 25, 2004
|Medtronic Inc
|Delivery of agents using hydrolyzable leaving groups
|U.S. Classification
|525/419, 525/937, 424/422, 424/486, 604/27, 424/484, 525/938, 604/48, 424/423, 525/420, 424/426, 525/903
|International Classification
|Cooperative Classification
|European Classification
|Aug 17, 1998
Owner name: PENN STATE RESEARCH FOUNDATION, THE, PENNSYLVANIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LAURENCIN, CATO;ALLCOCK, HARRY;IBIM, SOBRASUA;AND OTHERS;REEL/FRAME:009390/0799;SIGNING DATES FROM 19980616 TO 19980812
|Oct 14, 2003
|Fee payment
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Free format text: CONFIRMATORY LICENSE;ASSIGNOR:PENNSYLVANIA STATE UNIVERSITY;REEL/FRAME:023134/0985
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Year of fee payment: 11


text:
Tornadoes ripping across Oklahoma left left 24 confirmed dead, including children, while as many as 91 are feared dead.
In the initial aftermath of the chaos, officials had confirmed 51 people had been killed. Authorities revised the number of confirmed dead down to 24 Tuesday morning, the Associated Press reported.
But the death toll may still spike, as local affiliate KFOR said 91 lives are feared lost.
SEE ALSO: Rep. James Lankford: 'Oklahomans watch out for Oklahomans'
More storms are expected, Fox News said. Twisters could touch down across Oklahoma and Arkansas on Tuesday, while flash flooding is emerging as a big threat in Arkansas, Texas and Louisiana, Fox News said.
Heading into Wednesday, the storms will go east into New York and Pennsylvania, with a slight chance for more rain, wind and lightning in Oklahoma and the Texas panhandle, Fox News said.
Disaster efforts were in full force in Moore, Okla., on Tuesday, as rescue workers sifted through the debris of a giant tornado that wiped out a community of 41,000, in Moore. Red Cross, National Guardsmen — all were on the scene, UPI reported.
SEE ALSO: Obama approves major disaster declaration for Oklahoma
Among the dead were as many as 20 children, with more feared dead. At least two elementary schools were devastated and a third collapsed, but all of those students were accounted for, with only slight injuries, said Oklahoma City's local television station, KWTV.
Two more schools were hit, Fox News reported on Tuesday morning. And dozens of third-graders are still unaccounted for, Fox News reported. Seventy children are in area hospitals for injuries, along with 145 adults.
"As long as we are here … we are going to hold out hope that we will find survivors," said Oklahoma Highway Patrol Trooper Betsy Randolph, in The Associated Press.


text:
fences hedges and gates
- 271 Pins
Modern Fence And Gates, Modern Front Yard Fence, Gardens Fence, Fence Ideas, Modern Fence Landscape, Modern Gates And Fence, Slats Fence, Contemporary Fence, Modern Fence Design
Vvertical slat fence
Nice contemporary fence design
Pool Fencing GOLD COAST AND BRISBANE
i love the way to wood transitions from the house to the fence to the gate. masterpiece.
Arterra Landscape, Fence, Landscape Architects, Eichler Homes, Palo Alto, Mid Century, House, Klopf Architecture, Open Eichler
Truly Open Eichler Home in Palo Alto, California by Klopf Architecture, Arterra Landscape Architects and Flegels Construction via @HomeDSGN
Other gates and fences for other houses
Truly Open Eichler House / Palo Alto, Calfornia. More photos at http://archinect.com/firms/project/83064183/truly-open-eichler-home/124129329
Open Eichler Home Renovation - Design Milk
interesting idea
Gardens Ideas, Privacy Screens, Outdoor Screens, Fence Railings, Curb Appeal, Outdoor Gardens, Gardens Design, Modern Home, Fence Wal
MCM privacy screen
Modern Home Remodeling
slatted fence
Home And Gardens, Decks Ideas, Gardens Design Ideas, Modern Gardens Design, Kitchens Ideas, Low Decks, Interiors Design, Backyard Planters, Decks Gardens
Deck idea
Low #modern garden design #garden design ideas #garden design
Low #garden decorating #garden interior design #modern garden design
Low deck #garden #house #exterior
Landscape Design | Landscaper
love the entrance!
Natural Woods, Woods Fence, Front Yard, Modern Gates, Fence Gates, Modern House, Pivot Doors, Courtyards, Woods Gates
fenced front yard gate
Wood gate
Entrance Courtyard could be great -natural wood fences gate stylish modern house
courtyard entry, pivot door allows for a wide opening
natural wood modern gate
Foster + Partner screen detail
Facades, Metals Screens, Pattern, Bmce Headquart, Norman Foster, Casablanca Morocco, Sacred Geometry, Architecture, Geometric Shape
Screen from BMCE headquarters by Foster + Partners [Moroccan bank in Rabat and Casablanca]// Circles within circles, geometric shapes, architecture, metal
Foster + Partner screen detail facade
Pattern can be grounding, relaxing. Use sacred geometry Screen from BMCE headquarters by Foster + Partners
Banque Marocaine du Commerce Extérieur, BMCE headquarters in Casablanca, Morocco by architect Norman Foster and Partners fosterandpartners.com (2011)
::ARCHITECTURE:: Metal screen at the BMCE Bank in Morocco, by Foster + Partners
Trend design home 2012
Capetown, Roads 1843, Idea, Head Roads, Architecture Interiors, Home Interiors Design, Capes Town, Antony Association, Design Home
home interior design using wood material eco-freindly
SAOTA Architects and Antoni Associates Interiors - Signal Hill, Cape Town
capetown residence
Cliffhanger - desire to inspire - desiretoinspire.net
wood slat gap fence
Gardens Fence, Fence Ideas, Woods Fence, Horizontal Fence, Privacy Fences, Backyard, Landscape, Fence Design, Garden Fences
privacy fence ideas - Google Search
garden fences ideas garden fencing design ideas landscaping network 500x375
Horizontal fence design.
Metal and wood fencing, backyard screen, fences make good neighbors.
metal and wood fence designs | Garden Fence Design Ideas
Garden Fencing Design Ideas - Landscaping Network
Modern Cottages, Fence Ideas, Modern Fence, Color, Horizontal Fence, Fence Gates, Win Style, Yellow House, Slats Fence
horizontal fence gate
horizontal fence ideas
Modern Fence
Modern Cottage: Winning style
horizontal fence and also cute yellow house.. 8-)
Modern Cottage: horizontal slat fence
hORIZONTAl FEnCE- cOLoRS
Modern Cottage: Winning style
Gardens Design Ideas, Pools Fence Ideas, Fence Gates Ideas, Nice Fence, Trellis Ideas, Front Yard, Flower Gardens Design, Exterior Irons Fence, Beds Design
Nice fence
garden bed designs ideas flower garden design ideas home garden design ideas #Garden
Modern Trellis Ideas
Similar idea for front yard
privacy screen I really like this
Fence Decks, Backyard Ideas, Privacy Screens, Gardens, Mod Fence, Back Porches, House, Fence Gates Arbors, Fire Pit
privacy screen I really like this for around fire pit
privacy screen #PrivacyScreen #fence #deck
privacy screen I really like this mid mod fence
privacy screen for back porch near hottub
Maybe at the end of the garden
Coan Waterfront Remodel, Camano Island, Wa.
The Chedi Chiang Mai - love this as a feature fence.
Privacy Fence, Unique Style
LUMBER: "repurpose" weathered lap siding or snow fence into this beautifully unique style of privacy fence! The Chedi Chiang Mai -feature fence.
Like these proportions for a fence, too. Modern Pool Equipment Enclosure (Mangaris TM) - Pasadena, CA
Front Gardens, Privacy Fence, Gardens Fence, Fence California, Vertical Timber Fence, Pools Fence Screens, Projects Ideas, Beautiful Gardens, Modern Pools
vertical timber fence
Modern Pool Equipment Enclosure ( Mangaris TM) - Pasadena, CA
wood pool fence california - Google Search
I like to look of this for a privacy fence, could be made out of reclaimed wood.
Garden fence
pivot gate
Wood Gates, Gates Fence, Yard, Pivot Gates, Gates Design, Pivot Woods, Woods Gates
pivoting wood gate - Google Search
pivot gate to back yard
Wood gate design
Under Construction
Potrero HIll home by Nilus Designs with wood slatted fence
Patio Fence, Design Duo, Privacy Screens, House Fence, Nilus Design, Woods Slats, Slats Fence, Sf Design, Potrero Hill
Be My Valentine: At Home with an SF Design Duo: Remodelista
patio fence.
spanish house fence
Privacy screen! Potrero HIll home by Nilus Designs with wood slatted fence
Be My Valentine: At Home with an SF Design Duo: Remodelista
Privacy Fence/Screen
Privacy Fence, Mid Century Modern Yard, Outdoor Screens, Mid Century Patio, Patio Wall, Mid Century Chairs, Woods Slats, Outdoor Spaces, Patio Screens
Wood patio Screen
Privacy Fence on deck to block neighbors. Want to add lanterns on it too!
La Canada Mid Century Patio - oh, what I'd give to have an outdoor space like this
wood slat fence and blue stone tiles?
patio wall
Patio and outdoor screen
Beautiful fence!
Modern Fence And Gates, Gardens Fence, Fence Ideas, Kerítés Ötletek, Outdoor Gardens Screens, Japanese Fence, Japanese Gardens, Slats Fence, Gardens Screens Ideas
Horizontal slat fence stained dark. Repinned by Secret Design Studio, Melbourne. www.secretdesignstudio.com
fencing - fencing idea
modern Japanese fence
japanese garden fence panels - Google Search
Project: 11 Gurney | SEKSAN DESIGN - Landscape Architecture and Planning
Landscape Architecture, Landscape R
Dennings Ijssel, Beaches House, Courtyards Beaches, Fence G, Boards Fence, Capell Aan, Fences G, Of Dennings, Photo
Plan B Hoveniers | Tuinaanleg in Capelle aan den IJssel | Plan B Hoveniers
This could make a good house entrance Modernist Clishe's ie .spaced horizontal board fence, black framed pergola with fascade'
Mid-century modern iron entrance gate
Modern Entrance, Entrance Gates, Modern Irons, Gardens Design Ideas, Modern Gardens Design, Modern Gates, Modern Queen, Irons Entrance, Gates Gardens
Mid-century modern entrance gate
Mid-century modern queen palms
Black Fence oak Bench.
Painted Fences, Gardens Fence, Jardine Terrasse, Fence Colour, Black Fence, Backyard, Outdoor Spaces, Dark Fence, Garden Fences
Cozy outdoor space.
BLACK FENCE -MINUS THE MINIMALIST DECOR >>Black lifts the greens in a back garden. A hot tip is to use Alcro Black Deco when painting your garden fence. BLACK & TAN... stained/clear-coated wooden garden furniture.
Painted fence.
backyard #modern #simple black fence
Dark Fence + Greenery | Backyard
garden fence colours - Google Search
BEAUTIFUL BACKYARDS - Flowers And Gardens
I love looking at bothe the beauty and simplicity in which some people create. Cereza House / Warm Architects
Idea, Interiors, Front Doors, Warm Architects, House, Architecture, Gates, Design, Pivot Doors
Item 26A (Design feedback #1) - perhaps our people entry from Bangalla Road to the property could mimic the pivoting door of the front door, however I'll pin some other ideas for the outside fence which are similar to this but not quite so severe // CG
Luxurious Clever Cancún Interior Home Design by Warm Architects: Fascinating Outdoor Entrance Use Rotating Door House In Mexico
Awesome Volume House of Cereza 20 by Warm Architects in Cancun: Beautiful Cereza Home Design Exterior With Modern Welcome Gate Used Black Door Design Ideas And Concrete Flooring Style ~ SFXit Design Architecture Inspiration
Architecture Photography: Casa Cereza / Warm Architects (424489)
Modern front fence entry way. Corton steel gate, cantilevered timber pergola
Steel Fence, Steel Gates, Orange County, House Numbers, Metals Gates, Front Gates, Ocean View, Laidlaw Schultz, Front Fence
Beautiful house numbers steel bar. contemporary exterior by Laidlaw Schultz architects
metal gate
COR-TEN steel fence -- same company that makes the fountain.
Dream home in Corona del Mar with ocean views
Front Gate
Exterior - contemporary - exterior - orange county - Laidlaw Schultz architects
modern metal garden gate


text:
May 29, 2012Wooh! It's looking verrrry likely that we'll have the new choose your own adventure book ready for San Diego Comic-Con!
May 28, 2012Have I mentioned lately that we have a facebook club?
May 27, 2012WOOP! Just got my first issue from the Rider Haggard Society. I haven't felt this dorky in ages...
May 26, 2012Whee!
May 25, 2012Bookish shirts are back in stock in all sizes!
BAHFest Seattle 2015
BAHFest West 2015


text:
Stroketool-CT is a user friendly MS-Windows based software system for calculation and visualization of enhanced CT perfusion imaging data sets of the brain. It contains features such as quantitative perfusion using SVD algorithms; DICOM compatibility; rapid calculations of rCBF, MTT, rCBV, TTP,Tmax; and interactive and automatic AIF-detection.
URL: http://www.digitalimagesolutions.de
Resource ID: nif-0000-00345 Resource Type: Resource Version: Latest Version
stroke, software, system, calculation, visualization, imaging, brain, functional, perfusion, PWI, diffusion, DWI, magnetic resonance, MRI, tool
Software Resource, Data Visualization Software
Available to the research community


text:
We are looking for a logo for a mobile app + website. The title is "Smukfest Festapp" (the name is not required to appear in the logo).
The app is used for a music festival, and the keywords are in priority:
1. Music and party
2. Summer and (outside) fun with friends
3. Beer games/camping
Maybe some ideas:
- Pint beer + a music note
- Pint beer + headphones
- People (silhouette) + outdoor stage
- A happy/partying monkey (the nickname of the app translates to "party monkey" in English)
The app and website will supply users with news about the festival, interviews, chat, games, contests and other entertainment.
Colors, style etc. are 100% optional. We have no existing material that needs to be matched.
Seal your entry to ensure your idea is unique. Only you and the contest holder will be able to view your sealed entry.
Highlight your entry to make it visually stand out from the rest!
Please ensure the following:
Supported file types:


text:
Back to Previous Page
The Boss 302 returns to the road after 42 years.
Shaking Hands With The Devil
Watch as a Cobra Jet lines up with a Super Cobra Jet!
Make Your "Five-Oh" Go Faster and Smoother
If you love Ford performance, this is the place for you!
We put together some of our favorite articles about the Ford Mustang!
King of the Road
A Race Car For The Streets
Born on California's highways, the Mustang SSP offered police a high-performance alternative.
How to get up-close and personal to find the finest Ford Mustang you can afford.
A visual guide to telling one vintage Pony Car from its model-year stable mates.
Mustang's third body style emerges.
A visual feast for Mustang lovers.
A Real Jekyll & Hyde Ride
Upgrading a 1966 Mustang's Baer system from two-piston PBR caliper to six-piston Baer caliper.
A fitting end to the S-197 Mustang era.
Daytona Speedway was a fitting corral for these ponies.
Tulsa Raceway Park thundered with Ford power!
Carving corners with Ford power!
Walking around the paddock at Hallett Motor Racing Circuit
The Ultimate Ford Family Reunion
Fords invade downtown Tulsa's Brady Arts District
Walking around Tulsa Raceway Park
The capstone of a great event.
Families, fun and Mustangs at Myrtle Beach.
Are these cars the next great collectibles? Only time will tell...
Watch as David Williams from Fast Lane Classic Cars pulls the front wheels on his juiced Cobra!
The best old haulers of SEMA
AutoTrader Classics walks the show early for a sneak peak
A car guy's confession to not so temporary insanity.
Check out Bryan's latest project on Cafe Racer TV.
The work trucks of yesteryear captured in their element.
A fitting finale for an amazing Ford filled event!
It isn't very often that an attraction exceeds expectations by leaps and bounds, but the NASCAR Hall of Fame does so at every turn.
A quick sneak peak at the big show!
AutoTrader Classics Editor Brian Medford travels to Streetside Classics in Powder Springs, GA to check out their inventory and talk about some of their cars.
It takes a special woman to be a car guy's mother.
More kings of the street and strip.
Classic F-Bodies Storm Las Vegas
Things are moving fast at the site of the south's newest raceway.
From hauling cargo to hauling style.
These motorcars are a history lesson from the base of the automotive family tree.
Get a behind-the-scenes look at the world of NASCAR.
This year brought a wave of performance trucks meant for the tarmac.
Chevrolet's latest evolution of the Corvette was right at home with the classics.
Listen to Randy Grubb talk about the first time he drove the tank engine powered Blastolene Special!
The first cars roll into place for this exceptional exhibit of automotive design.
Wacky, weird, and sometimes just plain odd!
These trucks haul more smiles to the mile.
Check out our grab bag of cool cars.
provided by
by Brian Medford
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In this video the Flex picks off a modded Mustang GT.
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From Customs, Chevys, Fords to the Classics, these magazines provide the latest cutting edge information to fuel your passion.
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text:
PAS files another objection over two polls petitions
PAS today filed a second preliminary objection against the petitions filed by the Barisan Nasional (BN) over the results for the Bachok parliamentary and Jelawat state seats.
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text:
memoir and diary writing, Memoir writing »
Guest Blog: Our Transformation from a Journalling Circle to Creating a Book (Wendy and Ahava Writes)
May 18, 2015 | POST A COMMENT | by Tristine Rainer
GUEST BLOG: Our Transformation from a Journalling Circle to Creating a Book (Wendy and Ahava Writes)
Wendy Writes
We had been meeting for about two years. It just began to be clear to us, at that point, that we were not just journalling together but were embarking upon a larger project. I suppose we each dreamed into this new phase and it just felt right to us. We continued to journal together but, as we decided to type up some of our entries, we realised that this was not only for ourselves but we sensed it could be inspiration to others, as well. And then the momentum shifted and we began to bring together aspects from some of our individual work and formulating ideas together which became our "Four Practices" and then "Seven Principles."
I had been teaching writing, literature and women's studies for many years, as well as facilitating … Read the rest


text:
Scottie Wilbekin scored 21 points, had six assists and five steals to lead third-ranked Florida stepped up its defense after a porous first half to put away the Tennessee Volunteers for a huge Southeastern Conference road win Tuesday night.
Click here for the original story.
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At the Buzzer: Florida 67, Tennessee 58 (Instant Analysis)
Started by gatoraus, Feb 11 2014 08:10 PM
Posted 11 February 2014 - 08:10 PM
Posted 11 February 2014 - 09:46 PM
I hope cuonzo has a "dear john" letter waiting on him when he gets home.
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text:
US Forest Service to seek ideas for S. Vt. forestNovember 21,2013Forest Service
seeking input
MANCHESTER Officials with Vermonts Green Mountain National Forest are seeking ideas for forest management activities for sections of the forest south of Vermont Route 9.
Possible forest management activities include improving wildlife habitat and watershed conditions, improving forest health conditions, and providing high quality recreation and trail opportunities.
District Ranger Bill Jackson said the upcoming meetings are designed to gather information from the public.
The first meeting of the South of Route 9 Integrated Resource Project will be held today at the Readsboro School.
A meeting is scheduled for Dec. 3 in Pownal and Dec. 10 in Stamford.
All the meetings will be held from 6 to 8:30 p.m.MORE IN This Just In
Vermont State Police responded to a report of a bicycle accident on Route 4 in Killington... Full Story
PORTLAND, Maine — Some U.S. Full Story
Woman cited
after crash
POULTNEY — A Poultney woman was cited and released ... Full Story
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text:
Capote: A Biography
Carroll & Graf, 2005 - Biography & Autobiography - 635 pages
Based on hundreds of hours of interviews with the man who authored In Cold Blood and Breakfast at Tiffany's, as well as with nearly everyone who knew him, this absorbing, definitive biography follows Truman Capote from his eccentric childhood in Alabama to the heights of New York society. Featuring many photographs, this book also candidly recounts a gifted and celebrated writer's descent into the life of alcohol and drugs that would ultimately consume his bulldog spirit and staggering talent—but not before he'd hobnob with the likes of Grace Paley and Lee Radziwill, feud outrageously with Gore Vidal and Jacqueline Susann, and stage at New York's Plaza Hotel the sensational Black and White Ball.
What people are saying - Write a review
User ratings
|5 stars
|4 stars
|3 stars
|2 stars
|1 star
An interesting family reference in this book - Goodreads
Sad, a very sad ending. - Goodreads
What a great writer! - Goodreads
The research is remarkable. - Goodreads
I love Truman Capote's writing style. - Goodreads
Fascinating life, beautiful writing by Gerald Clarke. - Goodreads
Review: CapoteUser Review - Askoldw - Goodreads
I had often wondered how an author of such modest literary output had achieved such acclaim. So I read Clarke's book. I'm still not sure. He definitely was an effective self-promoter (maybe got that ... Read full review
Review: CapoteUser Review - Cristine - Goodreads
it was long so I got a little tired in the middle but still really good. very in depth and flowed as a story. Read full review


text:
YIELD: Serves 4
- 3 tablespoons vegetable oil
- 1 3 1/2-pound fryer chicken, cut into 8 pieces
- 1 medium onion, chopped
- 1 green bell pepper, cut into 3/4-inch pieces
- 3 large garlic cloves, chopped
- 1 14 1/2-ounce can Italian-style stewed tomatoes
- 1 11-ounce can whole kernel corn with juices
- 1 10-ounce package frozen large lima beans
- 1 1/2 teaspoons dried thyme
Heat oil in heavy large skillet over high heat. Season chicken with salt and pepper. Add chicken to skillet and sauté until brown, turning occasionally, about 15 minutes. Transfer chicken to plate. Pour off all but 2 tablespoons fat from skillet. Add onion, bell pepper and garlic and sauté until tender, about 5 minutes. Return chicken to skillet. Add tomatoes, corn, lima beans and thyme. Bring mixture to simmer. Reduce heat to medium, cover and simmer until chicken is tender, about 30 minutes. Transfer chicken to platter; tent with foil to keep warm. Boil liquid until reduced to sauce consistency, stirring occasionally, about 8 minutes. Season sauce with salt and pepper. Spoon sauce over chicken.
my notes
Nutritional Info
- Calories1,122
- Carbohydrates35 g (12%)
- Fat72 g (111%)
- Protein82 g (164%)
- Saturated Fat18 g (91%)
- Sodium549 mg (23%)
- Polyunsaturated Fat15 g
- Fiber8 g (34%)
- Monounsaturated Fat33 g
- Cholesterol298 mg (99%)


text:
Re: [Z_Scale] Re: New Tools Coming Soon!
Expand Messages
- To quote the middle of his front page:
More NTrak Tools and Zscale Standards Gauge.
I assume that means he is building a standards gauge for Z.
(Easy to miss...I did the first two times I looked)
----- Original Message -----
From: "pray59_3" <pray59@...>
To: "z scale" <email@example.com>
Sent: Wednesday, March 2, 2011 12:16:53 PM
Subject: [Z_Scale] Re: New Tools Coming Soon!
I cannot see anything listed as "New" on Rodney's site.
-Robert Ray
Z-scale: minimum siZe, MAXIMUM enjoyment!
Yahoo! Groups Links
Your message has been successfully submitted and would be delivered to recipients shortly.


text:
Anheuser-Busch InBev would take over SABMiller in deal worth well over $100B; combo needs regulators' OK
Top executives share their visions for success on CBSNews.com
It's still possible to find good housing deals for this price -- but pay close attention to the neighborhood
Airbus is giving new meaning to crowded conditions, with a design for stacking passengers
Whole Foods is sometimes called "Whole Paycheck" for its reputation of being pricey -- see 10 ways to save at this market
Midwestern cities dominate the top affordable places to live, according to a recent report
Some crafty and determined telemarketers and scammers plague our lives with auto-dialed calls -- but you can block them
While Americans are seeing anemic wage growth, some are taking home much healthier paychecks
A new study explores which major American cities are the most and least friendly for retirees and their needs
The FBI is warning criminals will still target EMV cards, while some groups stress security concerns
The PC company needs help to get beyond a stagnant market, but buying EMC may not do the trick
Why we find prices ending in 99 so charming, and other tricks that prompt us to fork over our cash
Scotland-born professor of economics and international affairs honored "for his analysis of consumption, poverty, and welfare"
Critics claimed the Affordable Care Act would lead to job losses and fewer hours worked, but here's the score so far
Buying a home? Find out the truth about down payments and other facts
As Dell moves to acquire EMC, a look at other notable purchases in the sector shows many didn't pan out as planned
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fountain of the crier, the name of the spring in Lehi which burst forth in answer to Samson's prayer when he was exhausted with the slaughter of the Philistines (Judg. 15:19). It has been identified with the spring 'Ayun Kara, near Zoreah.