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Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in immunocompromised or elderly patients. Although the clinical and pathological characteristics of these tumours have been defined the genetic alterations involved in their pathogenesis are not well known. In this study we have investigated the chromosomal alterations of MYC, BCL2, BCL6, MALT1, PAX5, and IGH loci using fluorescence in situ hybridization (FISH) in 42 plasmablastic lymphomas (PBL) and 3 extracavitary primary effusion lymphomas (PEL). MYC rearrangements were identified in 20 of 41 (49%) PBL and the immunoglobulin (IG) genes were the partners in most tumours. MYC rearrangements were more common in EBV-positive (14 of 19, 74%) than EBV-negative (9 of 21, 43%) tumours (p < 0.05). No rearrangements of BCL2, BCL6, MALT1 or PAX5 were detected in any PBL but gains of these loci were observed in 31-41% of the cases examined. Twelve of the 40 PBL in which 3 or more loci could be investigated had multiple simultaneous gains in 3 or more loci. No differences in the survival of the patients according to MYC were observed but the four patients with the longest survival (>50 months) had no or low number of gains (<3). No rearrangements of any of these loci were seen in PEL. In conclusion, PBL are genetically characterized by frequent IG/MYC translocations and gains in multiple chromosomal loci. The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection.
Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a diffuse proliferation of large B-cells usually with immunoblastic morphology and the immunophenotype of a terminally differentiated B-cell with loss of mature B-cell markers and expression of plasma cell related antigens.35 This tumor was initially recognized by Delecluse et al. and proposed as a subtype of diffuse large B-cell lymphoma (DLBCL) presenting in the oral cavity of HIV-infected individuals.16 Subsequent studies have recognized that PBL may present in other locations, mainly extranodal sites, and in patients with other immunodeficiency conditions such as iatrogenic immunosuppression associated with post-transplant therapy or chronic treatments for autoimmune diseases, and aging.14, 33
The clinical and pathological features of PBL have been well defined, and this tumor is now recognized in the current WHO classification. It is distinguished from usual diffuse large B-cell lymphomas, NOS (DLBCL) and other forms of large B-lymphomas expressing a terminally B-cell differentiation phenotype such as ALK positive large B-cell lymphoma, primary effusion lymphoma, and large cell lymphoma arising in multicentric Castelman's disease.35 However, the genetic and molecular mechanisms that may be involved in the pathogenesis of PBL are not well known. One important element in the development of the tumor is the infection of the neoplastic cells by Epstein-Barr virus (EBV), which is present in most the cases with a latency type I.14, 16, 17, 21 Immunohistochemical studies have observed the lack of expression of the cell cycle inhibitors p27 and p16 and strong expression of p53 in a number of cases suggesting that inactivation of these genes may contribute to the high rate of proliferation commonly seen in PBL.40
Conventional and molecular cytogenetic studies have identified a number of primary and secondary chromosomal aberrations associated with many types of lymphoid neoplasms including large B-cell lymphomas 4 but the genetic alterations of PBL have not been fully explored. Some studies have identified complex karyotypes including the presence of MYC rearrangements in occasional cases. However, these reports have included only isolated cases or small series of tumors.7, 13, 15, 36 Thus, the goal of this study was to more fully characterize the cytogenetic alterations that may be involved in the pathogenesis of PBL. We have investigated a large series of these tumors by fluorescence in situ hybridization (FISH) using probes covering genes and chromosomal regions frequently altered in aggressive B-cell lymphomas.
Forty-two cases of PBL were retrieved from the files of the laboratories of Pathology of the Hospital Clinic of Barcelona, Spain, National Cancer Institute, Bethesda, MD, Howard University Hospital of Washington, DC, and Rikshospitalet-Radiumhospitalet Medical Center of Oslo, Norway. The two cases from Howard University were previously published in part. 7, 13, 15 36 All the tumors were classified as PBL according to the WHO classification35 and further typified as PBL, monomorphic or "oral type" and PBL with plasmacytic differentiation as previously described.14 We also included in the study three extracavitary primary effusion lymphomas (PEL).12 Formalin-fixed and paraffin-embedded tissue was available in all the cases. Clinical information, including previous medical history, clinical presentation, and follow-up of the patients, was obtained to the extent possible from the referring pathologists and clinicians (Table 1).
Immunohistochemical studies were performed with a panel of monoclonal and polyclonal antibodies reactive in paraffin-embedded tissue sections using a peroxidase-labeled detection system, standard antigen retrieval protocols, and an automated immunostainer (Ventana Medical System, Tucson, AZ or Dako Autostainer, Dako, Copenhagen, Denmark), as previously described.14 The panel of antibodies used included common B-cell markers such as CD20 (clone L26), CD79a (clone JCB117) and PAX5 (clone 24), MUM1/IRF4 (clone MUM1p), CD138 (clones MI15, 5F-7, B-A38), and CD56 (clones 123C3, NCF-CD56-1B6), from DAKO and Ventana suppliers.
The presence of the Epstein-Barr virus (EBV) genome was examined by in situ hybridization (ISH) to detect EBV-encoded early nuclear RNAs (EBER1 and EBER2) as previously described.3 The EBV antigens LMP-1 and EBNA-2 were examined by immunohistochemistry using the CS1-4 (Dako) and NCL-EBV-Pe2 (Novocastra) antibodies, respectively. The antigen of latency (LANA-1) of HHV-8 was also studied by immunohistochemistry using the clone LN53 (Advanced Biotechnologies).
Conventional cytogenetics was available in three cases, two of them (cases 33 and 36) previously published, and the studies were performed as described.36
FISH was performed on 3-4μm thick sections of formalin-fixed paraffin-embedded tissues, using split-signal DNA probes (Dako) specific for the following loci: 8q24 (MYC), 18q21 (BCL2), 18q21 (MALT1), 9p13 (PAX5), 3q27 (BCL6) and 14q32 (IGH). In the cases with MYC rearrangements, we performed additional studies with a dual color-dual fusion MYC/IGH/CEP8 translocation probe (Abbott Molecular, Illinois, USA).
The FISH technique was performed following the guidelines of the Euro-FISH project as previously described (www.euro-fish.org).39 Briefly, a dewaxing step was followed by a pre-treatment process at 95°C, digestion with pepsin, washes with wash buffer, and dehydration with gradual ethanol dilutions. For the split probes, the slides were air dried and 10μl of the probe was applied in every sample. For the fusion probe, a mix of 7 μl of buffer solution, 2 μl of distillated water and 1 μl of probe were used. Denaturation at 82°C for 5 minutes and incubation at 45°C overnight were performed for the split probes. For the fusion probe the denaturation step was 3 minutes at 90°C, and the incubation 37°C overnight. The slides were then transferred to a stringency buffer at 65°C, washed in buffer solution, dehydrated, air dried and mounted with Fluorescent Mounting Medium containing DAPI (Dako). The slides were stored in the dark at 2-8°C until read. An Olympus BX51 microscopy (Olympus, Tokyo, Japan) was used.
The cut-off values for the interphase FISH analyses were established following the criteria of Ventura et al.41 Tonsil sections were used as controls, and for each sample 100 to 200 evaluable nuclei with complete FISH signals were scored. For the break-apart probes, the cut-off values were 3% for the detection of the rearrangements, and 6% to detect gains. For the dual fusion probe we considered a cut-off of 11% for both structural and numerical abnormalities.
Categorical data were compared using Fisher's exact test, two-sided P value, whereas for ordinal data non-parametric tests were used. The actuarial survival analysis was performed according to the method described by Kaplan and Meier. Statistical analysis was done using the SPSS software package version 15 (SPSS, Chicago, IL).
The main clinical data of the 42 PBL and 3 extracavitary variants of PEL are summarized in Table 1 and Table 2. Patients with PBL were predominantly males (81%) and had a median age of 48 years (range 11-86). HIV was positive in 27 (73%) of 37 patients with available information. Two HIV negative patients developed PBL after iatrogenic immunosuppression for Crohn's disease and renal transplantation, respectively. Five patients were older than 65 years, HIV negative, and did not have other recognized causes of immunodeficiency. Thirty (71%) of the 42 PBL were presented in extranodal sites. The most common single site was the oral mucosa (37%) followed by the gastrointestinal tract (20%), soft tissue (20%) and skin (10%). The clinical presentation in monomorphic PBL and tumors with plasmacytic differentiation was relatively similar with a tendency of the latter to have nodal involvement (43% vs 21%) but the difference was not statistically significant (Table 1). The clinical follow-up was available in 16 patients, 8 monomorphic PBL and 8 showing plasmacytic differentiation (Table 2). No significant differences in the overall survival of the patients with these two variants were observed.
All the patients with PEL were HIV positive. One patient had a solitary paravertebral mass from T12 to L2 (case 44). No other sites of involvement were detected and the patient was alive with no evidence of disease 3 years later. Two patients (cases 43 and 45) presented with a large cervical lymphadenopathy (case 43) and simultaneous axillary and retroperitoneal enlarged lymph nodes (case 45). In case 45, clinical information was available and the patient died rapidly after the diagnosis (2 months).
The 42 PBL were further subclassified as monomorphic PBL (28 cases) and PBL with plasmacytic differentiation (14 cases) as previously defined.14 All cases were negative for CD20 whereas CD79a was expressed in 14 cases (Table 1). PAX-5 was only positive in one case that also expressed focal CD79a. All the other cases were PAX-5 negative or weakly positive. MUM-1 and CD138 were positive in 20 (100%) and 26 (81%) of the tumors examined, respectively, with a similar proportion in monomorphic PBL and tumors with plasmacytic differentiation. CD56 was expressed in 5 (36%) of the 14 PBL with plasmacytic differentiation but only in 2 (9%) of the 23 monomorphic PBL examined (p<0.05). EBV was positive in 24 (59%) of the 41 PBL with a similar distribution in the monomorphic and plasmacytic variants (Table 1). Most of the cases had a latency type 1 with expression of EBER but negative for LMP1 and EBNA2. Only two monomorphic PBL showed occasional cells positive for LMP1.
The extracavitary PEL were cytologically composed of large immunoblasts and plasmablasts admixed with more occasional anaplastic cells. One nodal case (case 43) showed a predominantly sinusoidal involvement whereas the other had a tumoral and destructive pattern of growth. All cases expressed the HHV-8 latency antigen LANA-1 and EBV was present in two of the three cases with a type I latency.
Conventional cytogenetics were available in one monomorphic PBL (case 21) and 2 PBL with plasma cell differentiation (cases 33 and 36). Two of these cases were previously reported (cases 33, 36).36 All had complex karyotypes with MYC rearrangements. In case 16 the partner of the 8q24.1 rearrangement was the 2p12 region where the immunoglobulin kappa light chain locus is located, whereas in the other two cases MYC was rearranged with the immunoglobulin heavy chain locus. The complete karyotypes of the cases are shown in supplementary table 1.
The results of the FISH studies are summarized in table 3. We first studied the MYC locus with a dual-color break-apart probe. MYC rearrangements were observed in 20 (49%) of the 41 PBL evaluable. These rearrangements were more frequent in monomorphic PBL (16 of 28, 57%) than in PBL with plasmacytic differentiation (4 of 13, 31%), but this difference was not statistically significant.
To determine whether the IGH gene was the possible partner of the rearranged MYC, we investigated the MYC/IGH dual color-dual fusion probe in 15 cases (table 2). MYC was translocated with the IGH locus in 14 cases, 12 monomorphic PBL and 2 PBL with plasmacytic differentiation (Figure 1). Two monomorphic PBL in which the fusion probe could not be examined had both MYC and IGH rearrangements with the respective split probes and a normal pattern of the other loci (BCL2, BCL6, MALT1, PAX5) suggesting that IGH could be also the MYC partner in these cases. Four cases had a non-IGH MYC rearrangement and one of them had the t(2;8) detected by conventional cytogenetics. Thus, MYC rearrangements with IG gene loci were confirmed in 15 cases and suggested in two additional tumors. Only one case with a split in the IGH locus did not have MYC rearrangements (case 34). No rearrangements of the other loci studied were observed in this case.
The MYC rearrangement was the unique genetic alteration observed in 10 of the 39 PBL in which at least 3 of the other loci (BCL2, BCL6, MALT1 and PAX5) could be examined (table 2). All cases with MYC rearrangement as a single alteration were monomorphic PBL. MYC rearrangements were more commonly found in the EBV-positive cases (14 of 19, 74%) than in the EBV-negative cases (9 of 21, 43%) (p < 0.05). The median overall survival of patients with and without MYC rearrangements was 7 and 15 months, respectively. This difference was not statistically significant.
No rearrangements of BCL2, BCL6, MALT1 or PAX5 were detected in any PBL but gains of these loci were observed in 31-41% of the cases examined (Table 3). Gains of PAX5 were significantly more common in PBL with plasmacytic differentiation (7 of 13, 54%) than in monomorphic tumors (5 of 24, 21%) (p=0.041). No other associations were observed. Twelve of the 40 PBL in which 3 or more loci could be investigated had multiple simultaneous gains in 3 or more loci, whereas single gains were detected only in 3 tumors (Fig 2). Multiple gains were more frequent in PBL with plasmacytic differentiation (43%) than in the monomorphic variant (23%), but the difference was not statistically significant (Table 3). BCL2 and MALT1 loci were evaluable simultaneously in 31 cases. Coamplification of both loci was observed in 11 tumors and only one additional case had gains of BCL2 but not of MALT1. The median overall survival of patients with 3 or more gains was 7 months whereas it was not reached in patients with fewer than 3 gains. The difference was not statistically significant, probably due to the low number of patients. Of note, however, the 4 patients with the longest survival (>50 months) had no or fewer than 3 gains.
No rearrangements in any of the loci examined were observed in the three extracavitary PEL. One case had concomitant gains in BCL2, MALT1 and PAX5. Isolated gains of MYC were observed in an additional tumor.
Plasmablastic lymphoma is recognized as a distinct category of aggressive lymphoma with specific clinical and pathological features.35 However, little is known about the molecular and cytogenetic abnormalities of this tumor. The incidence of PBL is low and conventional cytogenetics or other techniques are difficult to perform because of the frequent lack of availability of fresh or frozen samples. For these reasons we have conducted a genetic study of these lymphomas using FISH and a panel of probes covering the genes and chromosomal regions most frequently altered in aggressive large B-cell lymphomas.
MYC rearrangements were the most common recurrent structural chromosomal alteration identified in PBL. They occurred in almost 50% of the cases and the immunoglobulin (IG) genes were the MYC partners in most tumors. We identified the t(8;14) using the fusion MYC/IGH probe in the 14 cases that could be examined. In two additional tumors simultaneous split signals of the MYC and IGH loci were observed, with the breakapart probes suggesting also the presence of the MYC/IGH rearrangement. In one of the 4 cases in which the MYC rearrangement was associated with a non-rearranged IGH locus, a t(2;8) translocation was demonstrated by conventional cytogenetics. Thus, these results indicate that IG genes were the partner of MYC rearrangements in at least 17 of the 20 (85%) PBL. These findings are consistent with previous observations of MYC rearrangements in single case reports of PBL13, 15, 42 or small series.7, 36 IG/MYC rearrangements were detected in the 9 cases in which both loci were examined. Conventional cytogenetic studies in PBL are very limited but the previous 7 cases published and our new reported case have been concordant with the FISH observations and show that the MYC translocations occur in the context of very complex karytotypes.7, 13, 36, 42
In addition to MYC translocations, PBL had frequent gains of the other loci examined with 30% of the cases showing gains in three or more of them. These findings are consistent with the complex karyotypes observed in the few conventional cytogenetic studies available. MYC rearrangements were seen more frequently in EBV+ PBL and tumors with a monomorphic morphology, but this latter difference was not statistically significant. Although the number of patients with follow-up information was limited, no differences in the survival related to these genetic alterations were observed. Interestingly, some of our patients exhibited long survival and all of them had no or very few gains in the loci studied. Although the initial descriptions of PBL highlighted the aggressive behavior and poor outcome, some recent reports have observed longer survivals similar to some of our patients.11 This improvement in outcome has been related to new antiretroviral treatments, better immunological status of the patients, and improvements in the supportive care and delivery of chemotherapy.
MYC rearrangement is a genetic feature characteristic of Burkitt's lymphoma (BL) and more recently has been also recognize in subsets of DLBCL with very aggressive clinical behavior.25, 31, 34 Our results indicate that MYC translocations are also a common finding in PBL. Although all three of these lymphomas share the presence of MYC rearrangements, the incidence, MYC partner and genomic context in which this translocation emerges are different. Thus, in BL MYC translocation is present in virtually all cases, the partner is an IG gene, usually IGH and less frequently IGK or IGL, and the translocation is the sole genetic alteration or is associated with very simple karyotypes. By contrast, a MYC translocation has been reported in 4-10% of DLBCL, usually associated with complex karyotypes23, 32, and in around 40% of the cases MYC is rearranged to a non-IG partner.23 MYC rearrangements have been also associated with the t(14;18) or BCL6 rearrangements in a subset of very aggressive lymphomas now recognized in the WHO classification as the provisional category of B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL.13, 35 These translocations are associated with very complex karyotypes.23, 32, 34 Interestingly, the majority of the subtypes of lymphoma with MYC translocations have a germinal centre phenotype. Thus, PBL carrying the MYC translocation show significant differences from other tumors that are MYC-translocation positive. The translocation is relatively common in PBL (50%), it is associated with complex karytotypes but without other translocations considered as "double hits", the partner is an IG locus, and the translocation occurs in a lymphoma with a terminal B-cell phenotype.
In addition to the MYC translocation we found gains in three or more loci in 30% of the PBL. These gains tended to be more common in tumors with plasmacytic differentiation than in the monomorphic variant. Although 3q27 (BCL6) and 18q21 (BCL2 or MALT1) translocations are common in other types of DLBCL and are associated with the MYC translocation in the "double hit" tumors,38 PBL do not have rearrangements in any of these loci. Gains of chromosome 3, particularly 3q, and 18q are common features of DLBCL of the GCB and ABC types, respectively.5 However, these alterations are mutually exclusive in most of these tumors.5 On the contrary, PBL have frequently simultaneous gains of these loci, reinforcing the idea that these tumors are genetically distinct from conventional DLBCL. Moreover, a recent study shows a different profile of gains in DLBCL arising in HIV-positive patients. This study, based on SNPs array-CGH, obtains a very low frequency of gains of the genes included in our series.10
Plasmablastic lymphoma, particularly the plasmacytic variant, has morphological and immunophenotypic features overlapping with extramedullary plasmablastic transformation of plasma cell neoplasms.14, 36, 40 The clinical context, immunodeficiency status of the patient and EBV infection of the tumor are characteristics that may help to distinguish these two entities. MYC translocations in primary extramedullary plasmacytomas are uncommon but polysomies and IG gene breaks not associated with MYC are frequent.6 In multiple myeloma (MM), MYC rearrangements have been detected in 0-15% of unselected cases2, 29, 37 but they may be seen in 45% of advanced MM and in 65% of MM cell lines19, 20 indicating that this may be an acquired alteration associated with progression of the disease. However, about 40% of these MYC translocations involve a non-IG partner, a finding different from the frequent IG/MYC rearrangements observed in PBL. On the other hand, MM have frequent rearrangements of the IGH locus with partner other than MYC (i.e. CCND1, FGFR3, CCND3, MAF)19, 20 whereas IGH rearrangements in PBL seem to occur almost exclusively with MYC.
Primary effusion lymphomas also share morphological and immunophenotypic characteristics with PBL but the clinical context and the tumor infection by HHV8 are distinctive features. Genetic studies of PEL have shown complex karyotypes but not rearrangements of MYC, BCL2, BCL6 or other recurrent alterations.1, 8, 9MYC translocations have been detected, however, in some cases of DLBCL presenting clinically as primary effusion lymphomas but the mature B-cell phenotype and lack of HHV8 in these tumors rule out the diagnosis of PEL.18, 24
The high frequency of IG/MYC translocations in PBL suggest that MYC activation must play an important role in the pathogenesis of these tumors. Most lymphomas with MYC rearrangements have a germinal center B-cell phenotype whereas in PBL the activation of this gene occurs in the context of a terminal B-cell differentiation stage. One of the master regulators of plasma cell differentiation is the transcription factor BLIMP1 and this transcription factor is highly expressed in PBL.3, 22, 30 BLIMP1 represses genes that maintain mature B-cell identity such as PAX5, and promotes the expression of genes such as XBP1 involved in the plasma cell differentiation program. BLIMP1 also represses genes related to cell proliferation and growth including MYC.28 The frequent incidence of MYC translocation in PBL may be an oncogenic mechanism that overcomes the repressor effect of BLIMP1 on MYC expression.
The IG/MYC translocations in PBL were frequently associated with EBV infection. This finding is similarly to BL in which EBV is also a common finding, particularly in endemic and immunodeficiency associated tumors.13, 35 The cooperative mechanisms between MYC and EBV in lymphomagenesis are not clear.27 Interestingly, experimental studies in tumor cell lines have shown that the full latency III program of EBV infection is incompatible with MYC-driven proliferation.26 Consistent with this in vitro observation, EBV infection in both PBL and BL has a latency I program. Further studies will be required to elucidate the relationship between EBV and MYC activation in PBL.
In conclusion, our study demonstrates that MYC translocations occur in 50% of PBL suggesting that it may play an important role in the pathogenesis of these tumors. MYC is usually rearranged with IG genes and the translocation occurs in the context of complex karyotypes. BCL2, BCL6, MALT1 and PAX5 loci are frequently gained but not rearranged in these tumors. These findings indicate that PBL have a specific profile of genetic alterations that differs from that seen in other aggressive B-cell malignancies.
We thank Elena Gonzalvo, Concha Muñoz and Laura Gelabert for their excellent technical assistance. We also acknowledge R.Ramos from Hospital Son Dureta, Mallorca, Spain, J.Miró from Clínica Girona, Girona, Spain, M.J.Panadés from Hospital Arnau de Vilanova, Lleida, Spain, C. Martín from Hospital de Sant Camil, Barcelona, Spain, S. Martínez from Hospital Joan XXIII, Tarragona, Spain, and A. Ferrández from Hospital Clínic of Valencia, Spain for their collaboration providing samples of patients with PBL diagnosis.
This study was supported by the Spanish Ministry of Science and Innovation SAF2008/3630, the Instituto de Salud Carlos III "Red Temática de Investigación Cooperativa de Cancer" RD07/0020/2004, Asociación Española Contra el Cáncer AECC_07_011 and Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias PI080095.
No conflicts of interest were declared.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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If you're an iOS user looking to schedule lights and appliances to turn on and off through a single app, then Insteon's HomeKit-compatible Hub fits the bill, and it has the potential to get even better, but as of now, it's too limited to recommend.
Lenovo's latest trio of Yoga tablets includes a model with a built-in pico projector and booming speakers.


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Monday, September 14, 1998
(c) Walt Disney Co.
Bob Carlisle gets a "Butterfly Kiss" while at Walt Disney World for Night of Joy.
Can two Contemporary Christian Music festivals draw crowds in the same town on the same weekend? Central Floridians found out that the answer was a resounding "Yes!" Friday and Saturday nights as fans flocked to both Walt Disney World's Night of Joy and Universal Studios Florida's Rock the Universe.
Two cool, crystal clear nights -- better weather couldn't have been planned -- offered two distinct, memorable bills of fare. The key was planning and diversity. Utilizing the eclectic nature of today's Christian music scene, each park's lineup focused on a different CCM specialty. Disney's 16th Night of Joy featured mainstream hitmakers including Bob Carlisle ("Butterfly Kisses"), God's Property ("Stomp") and Jars of Clay ("Flood").
Carlisle and Jars lit up the main stage at Cinderella Castle, interrupted for just a bit by Disney's regular "Fantasy in the Sky" fireworks display. The bigger bands played to hoards of fans each show. Teenagers filled the Castle's Courtyard to hear the pulse-pounding/high intensity Jars of Clay boys, who have found success on CCM, alt rock and mainstream pop radio. And Carlisle's adult-contemporary audience was also out in full force to hear and sing along with "Butterfly Kisses."
"I know what y'all came to hear, but you have to sit through all of my other songs first," Carlisle said. "I'm not stupid."
Smaller acts like 1998 Dove New Group of The Year Winner Avalon and newcomer Greg Long played more intimate venues around the park. Their sets included more personal interaction with the audience and emphasis on personal testimony. The connection kept ardent fans coming back for two and three sets.
(c) Alicia J. Wagner/The Orlando Sentinel
Newsboys perform at Rock the Universe.
Rock the Universe provided a more alternative bill which included harder acts such Audio Adrenaline and Newsboys Friday night and the kry and The Altered Saturday. Burlap to Cashmere was such a crowd favorite on Friday night that Universal asked them to play again on Saturday.
Universal's one nod to the mainstream, Michael W. Smith, played 3 concerts on Saturday, filling the main Hollywood stage for every show. Chris Rice and Wilshire, two new acts from his personal record label, Rocketown Records filled in during Smith's breaks. In addition to a huge band pieces from his new album, Smith sent his band off stage and regaled the audience with acoustic versions of hits like "Place in this World," "I Will Be Here for You," and "Friends." Also during the acoustic set, Smith led the crowd in favorite church choruses like "How Excellent is Thy Name."
"I'll bet that's the first time that song's ever been sung here," Smith said.
At the end of the weekend, each festival had found its place among fans, some choosing to attend one on the first night and the other on the second night. Upstart Rock the Universe played to a more-rock influenced crowd, with Night of Joy adding a layer of nostalgia, even with the artists.
"I saw Amy Grant at Night of Joy a long time ago, and I said to myself 'One day I'm going to be there,'" said Avalon's Jody McBrayer, a native of Tampa.


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|Reviews for Duty
| amr56 chapter 1 . 5/28
This was really interesting. I like Percy, and I can't imagine being so different from six different siblings. In the books it's always kind of a joke that he's the only responsible one, but it must be hard for him. Thanks for sharing.
| Guest chapter 1 . 6/5/2014
Ah, Percy getting the acknowledgement of his virtues at last. Thank you.
| EagleJarl chapter 1 . 4/17/2014
You have a real talent for taking the unlovable characters and making them admirable. Percy was always a prat in the books; it's nice to see him get some value. Also, it's very believable. I can completely see him doing this.
| mysinger chapter 1 . 1/11/2014
Good story. A different perspective on Percy.
| Hoodie Hugger chapter 1 . 12/21/2013
Percy's voice really needs to be heard. Sometimes I think that the Weasleys are very irresponsible with their money. Seriously, they won the raffle in the Daily Prophet in Ron's second year and instead of fixing the house or something, they went on vacation!
| wanderingsinthoughtspace chapter 1 . 5/23/2013
Nice idea. Thanks for writing.
| MuggleCreator chapter 1 . 1/10/2013
Oh Percy. Would it be that they understood.
| aurora-inked chapter 1 . 10/29/2012
This made me tear up slightly; it was like rebuking me for thinking Percy was such a prat even though he came back to his family in the end. Wonderful characterisation, as usual!
| Light on the Horizon chapter 1 . 12/31/2011
Loved this story. Great characterisation of Percy; it really fits in with the books as well :)
| Prof M McGonagall chapter 1 . 5/22/2008
I really liked this story. It's nice to see Percy in a good light, instead of having him seem like an uptight prat.
| friendlyquark chapter 1 . 6/15/2007
Thisis lovely and makes what happens in the books later even more poignant. Well done.
| Etar chapter 1 . 8/13/2006
This is great. I've always thought Percy was an intresting character but I've never read anything so in depth about him. This is one of those fics I wish I'd been able to right.
Thank you,
| unlikely2 chapter 1 . 3/13/2006
A really good take on Percy. I particularly like the way he attempts to become passionate about his boring but necessary job.
| TeenTypist chapter 1 . 3/12/2006
Magnificent piece of work! I never had considered that as a reason for Percy continuing to live at home; nice touch about how overworked his parents are. I definately feel Percy is a misunderstood character. You have done a fantastic job here, thank you for a great read.
| Ann-MCN chapter 1 . 8/25/2005
What a dear Percy! I like Arthur and Molly, and I do think Percy was helping out. Hope he's a good guy, in disguise.


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TODAY's Takeaway: Bloomberg won't run for president; Jill Biden talks love
1. Michael Bloomberg announced plans to bankroll a $50 million network to help curb gun violence and counter efforts by the NRA. Also, he's not running for president.
"No is the answer. Plain and simple," he told Savannah. "I'm going to spend the rest of my life trying to make a better world for myself, for my kids, for my grandchildren."
Bloomberg on NRA challenge: 'Not a battle of dollars'Play Video
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Hope to It: Saving lives from drug overdoses with a reversal injection
Shine a Light: Kids romp in new playground built by TODAY
The ATM fees you're paying are at a record high
Taylor Swift fans stuck with fake tickets are rescued by Rossen
2. Dr. Jill Biden visited the Orange Room to mark the third anniversary of Joining Forces. She also fielded TODAY viewers' questions, like what made her first fall for the vice president.
"I loved his two sons Bo and Hunter," Dr. Biden told Tamron. "I always say that I fell in love with the boys first."
Jill Biden reveals why she fell in love with JoePlay Video
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Instagram is 5 years old and the Orange Room is celebrating
Presidential politics, and guests appear in 'SNL' premiere
Watch this dad weep like a baby after baby news
Carson Daly celebrates breast cancer survivors in the 'Pink Room'
3. The parents of 9-month-old twins who were born conjoined and separated at just 1 month old told Savannah they're thrilled that their babies are finally coming home from the hospital.
"I'm so excited I'm shaking," Jenni Ezell said. "It's been such a long journey and we have finally arrived."
Parents look ahead as twins born conjoined head homePlay Video
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Hope to It: Saving lives from drug overdoses with a reversal injection
Shine a Light: Kids romp in new playground built by TODAY
The ATM fees you're paying are at a record high
Taylor Swift fans stuck with fake tickets are rescued by Rossen
4. Can you believe it's been 30 years since Cyndi Lauper released "Time After Time"? The singer stopped by to celebrate the anniversary, and told Carson and Savannah the song creation process for her is like a "cooking special."
"That's how I do music," she explained. "I take a little of that, and a little of this and mix it."
Cyndi Lauper performs 'Time After Time'Play Video
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J Balvin performs his single 'Ginza' on TODAY
Andrew McMahon performs 'Cecilia and the Satellite'
Darlene Love is back! She performs new single 'Forbidden Nights'
Iyaz teams with Nash of Hot Chelle Rae to perform 'Alive'
5. Christopher Meloni has taken to promoting his assets on social media, declaring his backside the "#BestButtInPrimetime" — but he insists he didn't start it.
"Rachel Harris, my co-star on 'Surviving Jack,' she started it," the actor said in TODAY's Take. "She lit the flame. ... I felt consumed by it. I was caught in the force fire of my butt."
Christopher Meloni 'consumed' by 'Best Butt' titlePlay Video
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Yogi Berra: Looking Back at a Legend in a Lifetime
Esai Morales On Latinos and Hollywood: "We Don't See Our People Save the Day"
Duchess Kate's First Solo Engagement Since Birth of Charlotte
Elton John Crank Called by Russian Pranksters
And that's TODAY's Takeaway!


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Our Viburnum Collection is recognized as one of the top three national collections. Our taxonomic display currently is home to over 100 different kinds and 330 living specimens.
[Description references: "Viburnums — Shrubs for Every Season" by Michael Dirr.]
Here are a few samples of this diverse and ornamental shrub.
1) Viburnum carlesii var. bitchiuense Bitchu Viburnum
- Wonderfully fragrant flowers in early spring.
- Closely allied to V. carlesii. Botanists still debate whether to "split" or "lump".
- Located across from the Graham Visitor Center in full flower. Grid: 40-3E
2) Viburnum macrocephalum Chinese Snowball Viburnum
- 6'-10' rounded shrub.
- Known for 3″ – 8″ wide, hemispherical cymes, hence the name "Snowball".
- Located along maintenance facility mixed-shrub border fence. Grid: 43-5E
3) Viburnum propinquum
- Large evergreen shrub with glossy three-veined leaves.
- Known to be tender in cold Pacific Northwest winters.
- Located in the Rhododendron Glen parking lot landscape. Grid: 12-8E
4) Viburnum x rhytidophylloides 'Alleghany' Lantanaphyllum Viburnum
- National Arboretum introduction in 1958.
- Handsome dense evergreen shrub with abundant inflorescences.
- Located in Viburnum Collection. Grid: 25-5W
5) Viburnum utile Service Viburnum
- Rare in commerce, but important evergreen species for breeding.
- Dirr doesn't think it has much ornamental value. I (David Zuckerman) disagree.
- Located in Viburnum Collection. Grid: 26-4W


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Get your vintage fix from amongst thousands of classic items of clothing & accessories on Oxfam's Online Shop. For more from Oxfam Vintage why not visit our Vintage page for tips on looking after your vintage clothing, the Oxfam vintage blog, and more!
Results 1-20 of 25
Vintage 70s Dorothy Perkins Size:L white & blue summer housecoat
Vintage 80's Dorothy Perkins size 12 navy & white polka-dot pleated dress
Vintage 80's Dorothy Perkins size 14 purple & grey floral dress
Country Casuals - Size: L - Pink - Trousers
Country Casuals Medium Navy Blue Flag Patterned Shirt
Vintage 70s Dorothy Perkins Size:14 black & silver skirt
Vintage Dorothy Perkins Size 10 Fire Orange And Lilac Striped Cotton Shorts
Vintage 80's, Dorothy Perkins size 14 multi-coloured blouse & skirt
Dorothy Perkins Vintage Size 14 Off White And Jet Black Striped Summer Dress
Country Casuals - Size: 12 - Orange/Yellow/Pink - Vintage skirt
Country Casuals Size 12 Black and Beige Woolen Jacket
Vintage Country Casuals, size 14 teal pleated skirt
Vintage 80's Country Casuals, size 12 red & navy pleated skirt
Vintage 80's Country Casuals, size 14 multi-coloured pleated skirt
Dorothy Perkins - Size Medium - Grey - Waistcoat
Country Casuals - Size: 14 - Multi-coloured- Casual jacket / coat
Vintage Dorothy Perkins Size 12 Brown Faux Snakeskin Jacket
Vintage 80's Country Casuals, size M cream & beige checked wool jacket
Dorothy Perkins - Size: 10 - Multi-coloured - Floral skirt
Vintage 80's, Dorothy Perkins size 10 black & red patterned two-piece
Page 1 of 2 | Showing 1-20 of 25
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We're here to help! Don't get stranded, just give us a call at (919) 249-5295, and we'll be on our way!
(919) 249-5295
If you're in need of auto repair in the Raleigh area, schedule an appointment online. We're excited to show you why USA Automotive remains drivers' first choice for all of their automotive needs.
We proudly offer a popular pre-purchase inspection so that you can be confident about your new (to you) vehicle. Schedule an appointment today!
Were you given a recommendation for a repair or service that you are unsure about? We offer a unique, Free 2nd Opinion on any services or repairs which have been suggested to you.
Even more, our work is guaranteed for both parts and labor for 3 years or 36,000 miles, whichever comes first. Our experienced mechanics are ASE Certified Technicians, and work on all makes and models of American and import cars, trucks, SUVS, minivans and hybrid automobiles. From oil changes, check engine light diagnostics, and brakes, to timing belts, muffler and exhaust repair and more, our talented team will help you every step of the way.
If you're in need of auto repair in the Raleigh area, give us a call at (919) 249-5295, schedule an appointment online, or stop by today. We're excited to show you why USA Automotive remains drivers' first choice for all of their automotive needs.
Only place to get my vehicle's worked on! – I take both my wife's and my vehicles to be serviced at USA Automotive. They have always provided great service along with a friendly and knowledgeable employees. They always inform me of what problem I have and explain the severity of it. They never try to up-sell or miss guide me on services my vehicles need. They also provide great coupons and reminders for services of our cars. Check them out and you will see the same. Thanks USA Automotive! – Anon
EXCELLENT CUSTOMER SERVICE!!! – We have three vehicles & only get them serviced at USA Automotive. Keith & his crew are honest & don't push extra services that you don't really need. They explain everything in simple terms & treat you like family! Excellent customer service!!! – Beth M.
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Judge: Religion Aside, Monkey Meat Needs Permit
Posted: 01/05/2009 - A federal judge in Brooklyn has rejected a Liberian woman's religious reasons for smuggling endangered monkey meat into the U.S.
Posted: 01/05/2009 - A federal judge in Brooklyn has rejected a Liberian woman's religious reasons for smuggling endangered monkey meat into the U.S.
Posted: 01/05/2009 - A woman with a bomb strapped under her robe has killed more than three dozen people outside a Baghdad mosque during ceremonies commemorating the death of a Shiite Muslim saint.
Posted: 01/05/2009 - A 28-year-old man has been charged in the beating and robbery of an elderly man outside a church in College Park, Maryland, on Christmas Eve.
Posted: 01/05/2009 - A Wisconsin county's top administrator says there shouldn't be any problem defending its Nativity scene on the courthouse lawn from a lawsuit that claims it's unconstitutional.
Posted: 01/05/2009 - They were at odds during the presidential campaign, but Gov. Mitt Romney says when his wife Ann fell ill recently, President-elect Barack Obama phoned to say she was in his prayers.
Posted: 01/05/2009 - Pope Benedict is urging Christians to pray "that baby Jesus in the manger might inspire" Israelis and Palestinians to immediately end the bloody conflict in the Gaza Strip.
Posted: 01/02/2009 - The Rev. Fred Shuttlesworth, a civil rights leader during the 1950s and 1960s, continues to improve from the pneumonia and dehydration that led to his hospitalization in Alabama a week ago.
Posted: 01/02/2009 - The man accused of killing one woman and wounding five others at the Jewish Federation of Greater Seattle won't face a second trial until more than three years after the shootings.
Posted: 01/02/2009 - A Pennsylvania judge has upheld the legality of a marriage performed by a man who was ordained in a matter of minutes by completing an online form with the Universal Life Church.
Posted: 01/02/2009 - Arkansas officials have asked a judge to take steps to remove from the Internet a leaked video in which a teenage follower of Tony Alamo defends the jailed evangelist and says he would never commit the sex crimes of which he is accused.
Posted: 01/02/2009 - Friends and relatives have crammed into an Idaho church to mourn 11-year-old Sage Aragon, who died while trying to trudge through 10 miles of snow on Christmas Day to reach her mother.
Posted: 01/02/2009 - A Wisconsin congregation has decided to leave the Episcopal Church to join a more conservative branch of the world Anglican Communion.
Posted: 01/02/2009 - Christian graduate students have been challenged to reconcile both faith and reason and faith and works at Intervarsity Christian Fellowship's Following Christ conference.
Posted: 01/02/2009 - Key speakers at this week's Intervarsity Christian Fellowship conference for graduate students have questioned whether pain from the world financial crisis is being fairly distributed.
Posted: 01/02/2009 - Pope Benedict is calling for major changes to the world financial system.
Posted: 12/31/2008 - The leader of an apocalyptic church in New Mexico has been sentenced to 10 years in prison for sexual misconduct with teenage female followers.
Posted: 12/31/2008 - A rare exhibit of Vatican art and artifacts is being extended an extra week in St. Paul, Minnesota.
Posted: 12/31/2008 - A charity that financed trips for Jewish youth to Israel but fell victim to Bernard Madoff's Ponzi scheme is reaching out to alumni to help save this year's planned trip.
Posted: 12/31/2008 - An Episcopal priest at a rural Pennsylvania parish has been ousted from priestly ministry for flamboyant partying at New York City nightclubs.
Posted: 12/31/2008 - A federal appeals court has refused to stop the government from taking DNA from a prisoner who claims the process would violate his religious beliefs.
Posted: 12/31/2008 - When he delivers the invocation at President-elect Barack Obama's inauguration, will the Rev. Rick Warren pray in Jesus' name?
Posted: 12/31/2008 - An atheist who has fought to remove the words "under God" from the pledge of allegiance wants to remove all religious references from the President-elect Barack Obama's inauguration.
Posted: 12/31/2008 - The Catholic charity Caritas says Ugandan rebels have killed more than 400 people in northeastern Congo since Christmas.
Posted: 12/31/2008 - Two British missionaries have been sentenced to one-year jail terms with hard labor in Gambia for criticizing the West African country's government.
Posted: 12/30/2008 - The Marine Corps has expanded its ranks much more quickly than military officials had expected.


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Select Local Merchants
Tranquility Salon & SpaRead MoreAfter renting a chair for seven years, Erika Cook, a stylist with 16 years of experience, was ready to move up. With the support of her family, friends, clients, and fiancé, she opened Tranquility Salon & Spa, where she and her staff perform everything from curls with Surface hair products to manicures with durable Shellac gel polish. Cook is doing everything she can to make the salon a success, especially by making as many services available as possible. Along with waxing and makeup applications, she offers hot-stone, sports, and other massage services, as well as glycolic-acid peels that reduce the worry lines that appear when you agonize too long over whether to buy ketchup or catsup.283 Main St.New Hartford, CT US
Sacred BeautyRead MoreSacred Rhythms Wellness Center's eight highly trained staffers aim to diffuse ailments with a suite of holistic services, from traditional massage to pain-relieving acupuncture. In private treatment rooms with flickering candles, holistic healers conduct chakra assessments before realigning energy points with reiki or sound therapy. The ancient art of cupping encourages the body to release toxins, and an herbal body wrap cloaks the corpus in an elixir of 27 minerals and herbs that lures impurities and uninvited dinner guests out of the skin. Clients can also indulge in organic facials blended from fruits, vegetables, spices, minerals, and vitamins, and the center's own skincare line, Sacred Skin, is also formulated in-house using naturally sourced, organic ingredients. The center offers yoga, tai chi, and meditation classes.120 Willow StWinsted, CT US
Simplicity Hair CareRead MoreThe sound of shears snipping away at split ends permeates Simplicity Hair Care, where salon owner Dawn Cyr draws on more than a decade of cosmetology experience to helm a team of professional stylists—all of whom pride themselves on using products that protect hair with limited artificial additives. The eco-friendly and fashion-forward salon's natural approach manifests in shelves stocked with low-ammonia hair color from Wella and sustainable styling products from Alterna Bamboo, Sebastian, and Wella. When they aren't taming curls or charming snakes on Gorgons' scalps, the stylists lengthen locks with extensions crafted from all-natural human hair or rein in frizz with texture-altering treatments.377 Main St.Pine Meadow, CT US
Hair TooRead MoreWhat services does your business offer and what makes your business stand out from the competition? E'Clips Salon & Barbershop takes an individualized approach to improving your look and will guarantee your satisfaction. What was the inspiration to start or run this business? The two owners Jessica and Keith enjoy what they do everyday. Here we have real passion for hair and it shows in every client. What do you love most about your job? There's no better feeling then making a person feel better about themselves and giving them true confidence.246 Main StWinsted, CT US
A Touch of Class Salon and Day SpaRead MoreWalk out of Winsted's A Touch of Class Salon and Day Spa absolutely glowing after a much-needed day of pampering. The professional nail care services at this salon will leave you with long-lasting, beautiful nails. This spa offers a wide variety of massages to suit your personal needs. Don't spend the whole weekend trying to tan. This spa can do the same work faster. Take advantage of its tanning services, including tanning beds, spray tan, and airbrush tan. Relax in luxury comfort at A Touch of Class Salon and Day Spa and leave with a new burst of confidence.120 Willow StWinsted, CT US
Head ShoppeRead MoreSwitch up your go-to haircut and color and leave Head Shoppe in New Hartford feeling like a brand new person. Keep up with the latest and greatest hair trends at this salon, a highly-rated and fashion-forward establishment. If you don't have cash on hand, you may pay for your service with one of your major credit cards, such as Visa or MasterCard. Whether you're fighting frizz or want to make over your mop, Head Shoppe provides rave results for every hair type (so book an appointment today!).526 Main StNew Hartford, CT US


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Shrimp Salad with Spring Pea Mix
Made without mayo, this company-worthy combo of egg, shrimp, and potato salad gets its creaminess from a tangy yogurt-and-mustard dressing. Plate it alongside fresh-picked peas tossed in a light lemon-dill vinaigrette.
Total Time:
Level: Moderate
Serves: 6
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- 12 large eggs
- 1 lemon
- 3 sprig Fresh dill
- 12 oz. large shrimp (16- to 20-count)
- 12 oz. Yukon gold potatoes
- salt
- pepper
- 12 oz. sugar snap peas
- 1½ c. frozen peas
- 1 c. plain yogurt
- 1 tbsp. Dijon mustard
- ½ c. finely chopped red onion (1 small onion)
- 3 stalk celery
- 1 tbsp. white wine vinegar
- 2 tbsp. olive oil
- In 4-quart saucepan, place eggs and enough cold water to cover by 1 inch. Heat to boiling on high; remove from heat. Cover and let stand 5 minutes. With slotted spoon, transfer eggs to colander. Rinse eggs under cold water until cool enough to handle; peel and cut in quarters. Set aside 12 quarters for garnish.
- From lemon, squeeze 3 tablespoons juice and reserve. To same saucepan of water, add lemon rind and dill stems; heat to boiling on high. Add shrimp, reduce heat to maintain bare simmer, and cook 3 minutes or until shrimp just turn opaque throughout. Drain, rinse under cold water until cool, and drain again. Discard lemon rind and dill sprigs.
- In same pan, place potatoes and enough cold water to cover. Add 1 teaspoon salt. Heat to boiling on high, cover, and reduce heat to simmer 15 minutes or until just tender; drain well.
- While potatoes cook, heat 3-quart saucepan of water to boiling on high. Add snap peas and frozen peas. Cook 2 minutes or until bright green; drain well.
- In large bowl, whisk yogurt, mustard, 1 tablespoon lemon juice, and 1/4 teaspoon each salt and freshly ground black pepper. Add hot potatoes, onion, celery, shrimp, eggs, and half of chopped dill. Fold gently until well combined.
- In another large bowl, whisk vinegar, oil, remaining 2 tablespoons lemon juice, and 1/8 teaspoon each salt and freshly ground black pepper; add all peas and remaining dill. Toss until well coated.
- Spoon shrimp salad into center of serving platter, then spoon pea mixture all around. Garnish with reserved egg quarters and serve immediately.
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10% Off When You Shop Selected Bakewear Over £30Get Voucher Code
- ⏰ Ends: 11/10/2015
Want to enjoy hassle free baking? Then here is the offer you must look for which gives you discount on the item you purchase with the help of this code.
By browsing the MyVoucherCodes site you're agreeing to the use of cookies. Cookies are tiny bits of data sites store in your web browser to make your online experience better.Not sure about cookies?
Want to enjoy hassle free baking? Then here is the offer you must look for which gives you discount on the item you purchase with the help of this code.
Debenhams has switched it's clearance to On now. Take this as a great chance and pick your clothing and home needs for with 50% off. Hurry up!
Whether to enjoy your dine out or to get some outdoor entertainment, this range of durable chairs and tables for 50% off is worth shopping for your lawn.
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The clearance event brings you the best prices with this discount deal on the essential items for home from bedding to kitchen items.
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Sofas and chairs, rugs and much more can be found at discount prices. Browse the collection and buy some of these to save money.
Jackets, chinos and trousers are made available in a single collection at discount prices, shop before the offer ends.
Make sure you find about about the very latest deals, sales and new products by registering for emails.
Offers for Debenhams were lasted updated Monday 5 October 2015 12:17
With 240 stores in 28 countries around the world, Debenhams is one of the biggest British retailers in the world. Specialising in a unique mix of British brands and international concessions, it is also the 11th most-visited online retailer in the UK.
Whether you're shopping for fashion, footwear, electronics or home accessories, you're bound to find what you're looking for. It's always worth checking out the vouchers and promo codes to use in-store or online, you never know what bargains you might bag in the Blue Cross Sale! From wedding gifts to beauty products, lingerie to bedding – simply browse the offers before you buy.
Fancy some new fashion, electricals, homeware or more but don't want to pay full price? You are definitely in the right place. Well, almost. The latest live Debenhams discount codes, offers and sales can be found at the top of this page. Here are a few top promotions from the past, so you know what you might expect to find.
We aim to get you money off the fashion, technology and homeware you really want, so we're constantly on the look-out for the biggest deals and most exclusive discounts. If you're a fan of this store, you might also like to check out our vouchers for John Lewis, House of Fraser and Marks & Spencer too!
To redeem your discount on a Debenhams purchase, simply follow these steps:
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Shopping at Debenhams has never been easier. You can now access the store straight from your mobile device; the app is fully compatible on iPad, iPhone, Android or Kindle. After downloading the app, the whole product range will literally be at your fingertips. When viewing the app in store, the app can become your personal assistant with the added feature of a scanner that allows you to view more product details. Other features include a store finder and you can choose to receive the latest alerts about sales and product trends.
Alternatively, browse the discounts and voucher codes via the MyVoucherCodes app. Wherever you are, you can still grab a bargain on the go!
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Since 1993, the 'Designers at Debenhams' clothing concessions brand has grown to be one of the most popular and successful ranges in the store. With the aim of bringing big brand names to the high street, it offers top fashion at affordable prices. There have been a number of high profile designers involved over the years – it currently includes the likes of Henry Holland, John Rocha, Betty Jackson, Matthew Williamson, Jeff Banks and many more.
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Debenhams doesn't only sell clothing, homeware and technology – it also offers a range of financial services. If you are interested in Pet, Home, Travel or Life Insurance or currency exchange, log onto Debenhams.com to find more information or ask in your local store.
Once you've browsed Debenhams, you might want to carry on shopping. If you do, we know of the perfect retailer to continue your spree. Head over to our Amazon offer page now to get the biggest deals available online.
Debenhams PLC
10 Brock Street
Regent's Place
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Welcome to Saint Andrew
Saint Andrew Lutheran Church, located on the north side of Rib Mountain, serves the wider community of the Wausau area as a congregation of the Evangelical Lutheran Church in America. The ministry of Saint Andrew is "open to all who wish to express their faith in God through Jesus Christ by worship, learning, witness, and service." Mission Statement
Welcome back to church!
"All are Welcome." This is a common theme at Saint Andrew that is not intended to be a nice catch phrase that sounds inviting but rather a challenge for us to practice those words and live them through inttentional invitation and engaging participation.
Whether you are here every week, or you have been away for the summer, or it has been years since you have walked through the front doors of a church, fall is a great time to say "welcome back." With fall approaching, we return to a more regular pattern of life and ministry through Saint Andrew. New this fall is the addition of a third worship service for Sunday morning, a slight revision to the Sunday school schedule, a staffed nursery, and several Bible study opportunities. All these and more are sure to bring about a spirit of change,challenge and opportunity to connect more fully into the life of Christ's church. Whether returing after being away or coming for the first time, please know that "all are welcome" for Christ is the one who invites and promises to meet us as we gather in his name.
Sunday morning format this fall -
8:00 & 9:30 am
Sunday School
Children may meet directly in classrooms or begin in worship with their families and then dismissed following the children's sermon.
A community that is loving...
"I am so grateful for the time I spent as a confirmation small group mentor! Spending two years with the young ladies and gentlemen, witnessing their growth as individuals and in their faith, provided me with great satisfaction!! However, I believe it was my own growth in my faith and knowledge of the bible that provided the greatest satisfaction! I hadn't been in confirmation, or any faith study group, since I was a teen. If you desire to live in a community that is more loving, accepting, and faithful to God, mentoring our youth is a great place to start!! And the bonus is that you will also grow to be more loving, accepting and faithful to God as well!!"
(Sheri is a confirmation mentor and has been a member of Saint Andrew since 1999)
Thursday Sunday
12:15 & 6:15 pm 8:00, 9:30 & 10:45 am
Weekly worship services are opportunities to encounter God's Word, to share a meal at the Lord's table, and to be sent into the world to serve. Throughout the Church Year, people of faith gather in worship to recall, proclaim, and participate in the mystery of Christ's life, death, and resurrection. Whether you have been to church before or are seeking to grow in a community of faith - come and hear about God's love for you at Saint Andrew, a place that is open to all!


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The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
all the expressive, creative, and inspirational personalities of our community!
Send-off My Regards Men's Tee
Gift this heather-grey T-shirt to your guy friend just before he embarks on a new life experience. Screenprinted with a colorful, retro spaceship to coordinate with his high-aiming aspirations, this soft shirt is a stylish one in which to greet his new city. Try this tee for yourself, too, as ...
ModSloth Men's Tee
Whether conquering film class or taking on the town with his easygoing personality, your guy friend will be a giant hit when sporting this T-shirt! Youll watch his style score climb as soon as he slips into the plane-swirling screenprint on the front of this wear, especially with his pairing ...
Come Check It Out Men's Tee
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Remarkable fashion & decor, inspired by our community, & delivered with uncommon care.
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Country Inn & Suites By Carlson, Chippewa Falls
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Continental Breakfast
- Free High-Speed Internet
- Swimming pool
- Fitness/Health center
- Wheelchair accessibility
Travelers also recommend:
- More recommendations
TripAdvisor Reviews Country Inn & Suites By Carlson, Chippewa Falls
Travel Blogs from Chippewa Falls
I have run away to live in Wisconsin!
... Bo saw a less than sophisticated woman looking for cigarette butts on the ground. Unfortunately it was 7:30pm and we were too tired to moved, so we ensured everything was locked up and went to bed. We didn't venture to the pool or anything as we didn't feel like it was safe to leave our stuff. We woke up at 6am and were gone by 7am. On the 22nd (yesterday) we started our day off driving past Bogarts Road... You can imagine Bo's excitement here! We ...
Lovely Wisconsin
... storm.
At Leinie's Lodge, you pay $5 and get 5 good sized samples of beers. Then, when you're done, you get a token beer glass (and, of course, you can ...
Day 2 Osseo to Effingham
... tostito chips and paper plates...9.42 cash.
On the road from Osseo at 9:30.
Stopped for a nap just before Janesville, WI. Joel made a cup of coffee and we had cheese/crackers and cookies......turned out to be lunch since we had such big breakfasts.
Stopped for gas at Mendota, IL......91.83 visa.
Had planned to stop ...
Work cited
... br> Basilica Cistern, Istanbul. (n.d.). Retrieved March 10, 2015, from http://www.tripadvisor.com/Attraction_R eview-g293974-d294555-Reviews-Basilica_ Cistern-Istanbul.html
Best Destinations in the World - Travelers' Choice Awards - TripAdvisor. (n.d.). Retrieved March 11, 2015, from ...
O'Neil Creek RV Park
The wind blew and it misted rain all night. We drove around the area again today and then visited with Glen and Lois Ogle this afternoon. They had 2" of snow on the ground this morning. It has been in the 40's all day. A lot of the leaves have fallen ...


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Search by BreedSearch Breeders by Tennessee Gun Dog Classifieds
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4XGMPR Sired Pointing Lab Pups Spring Creek Kennels in Newtown, Missouri
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Thunder Ridge Kennels - Tennessee Labrador Retriever Breeders
Want to list your puppies for sale? Post a classified today!
About Thunder Ridge Kennels
Specialize in AKC and UKC field trials.12 Year UKC License Field Trial Judge.
I have a 7 year old black lab retriever female, HR title with UKC, picked up 1300 ducks and 300 geese.Certified hips with computer chip.For Sale:$2000
Call for more information: 731-676-7776
Hunting Dog Breeds Raised
Labrador Retriever
Breeder Contact Info
Joe King
1910 Rambo Road
Dyersburg, Tennessee 38024
Breeding quality gun dogs for over 29 years.
731-676-7775Send Email to Thunder Ridge Kennels
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The real Christians do not believes that Jews need to become Christians to determine Jesus to come back and start to reign. We believe that no man, Jew or gentiles can become real Christian unless they have a special revelation from Jesus. Then we do not try to convert any Jews because we CANNOT, base on our faith this work is made from above and from above only. We love Israel and Jew people because Jesus is a Jew and because the G-d of Abraham, Isaac and Jacob command it. We have no hidden agenda, we pray daily for Israel and its peace.
Woman wounded by stones thrown toward her car near Jerusalem (Haaretz)
from the article: With friends like Glenn Beck...


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Genmab A/S Summons Annual General Meeting
Summary: Genmab to hold Annual General Meeting on April 23, 2008
COPENHAGEN, Denmark, April 7 /PRNewswire-FirstCall/ -- Genmab A/S (OMX: GEN) summon the Annual General Meeting on Wednesday April 23, 2008 at 3:00 pm CEST at the Radisson SAS Scandinavia Hotel, Amager Boulevard 70, 2300 Copenhagen S, Denmark.
1. Report of the Board of Directors on the Company's activities during the year.
2. Presentation of the audited Annual Report 2007 for approval and the discharge of the Board of Directors and the Management.
3. Decision as to the settlement of loss according to the approved Annual Report.
The Board of Directors proposes that the year's loss of DKK 373 million be carried forward by transfer to accumulated deficit.
4. Election of members of the Board of Directors.
Pursuant to Article 13 of the Company's Articles of Association, the members of the Board of Directors are elected for periods of three years. The election period for Michael B. Widmer and Karsten Havkrog Pedersen expires at the General Meeting. The Board of Directors proposes to re-elect Michael B. Widmer and Karsten Havkrog Pedersen for a further three-year period.
About Michael B. Widmer
Dr. Widmer is Chairman of our board of directors and has been a member
of our board since March 2002. Dr. Widmer is the former Vice President and
Director of Biological Sciences of Immunex Corporation in Seattle. Prior to
joining Immunex in 1984, he was an assistant professor in Laboratory
Medicine and Pathology at the University of Minnesota. He is a former
Scholar of the Leukemia Society of America. His research has centered on
regulation of the immune and inflammatory response. He has authored over
100 scientific publications. During his tenure at Immunex, Dr. Widmer
pioneered the use of cytokine antagonists, particularly soluble cytokine
receptors, as pharmacologic regul
|SOURCE Genmab A/S
Copyright©2008 PR Newswire.
All rights reserved


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Chop Stix Strips: Strip-Pieced Asian-Themed Lap Quilt Pattern
The cool, graphic design in this Chop Stix Strips lap quilt pattern showcases Asian-themed fabrics. This versatile pattern allows you to substitute fabrics of any other theme (florals, repros, etc.) to make a quilt uniquely yours.
Finished Size 58½˝ x 69˝
Featured Fabrics
Dorie used assorted fabrics from her stash to make this quilt.
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FREE Quilt Patterns to download from McCall's Quilting Quilt Pattern Index.
FREE Quilt Block Patterns to download from McCall's Quilting Block Reference Library.
This Chop Stix Strips quilt is fully patterned in the McCall's Quick Quilts issue below. Click here to purchase print (while supplies last) or digital download of this McCall's Quick Quilts issue from our online Quilt & Sew Shop.
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Mind Over Splatter
Tonight's film: Ravenous.
For Theresa Mercado, there's never a bad time for horror movies. While most people were planning backyard barbecues, she was launching her Cruel Summer horror film series. Now, as the weather turns cold, it's time to launch Cruel Winter with the Stephen King/David Cronenberg collaboration The Dead Zone.
"I'm a huge fan of David Cronenberg, and this is one of his more overlooked movies. Not a lot of people have seen it, and even people who have don't realize it's Cronenberg," Mercado says. "[Plus] it's from a Stephen King story, which I used to love reading as a teenager, so it's a perfect mix."
As usual, Mercado will provide handmade souvenirs to everyone who attends, and drink specials tied to the featured film will be offered.
"There's more to these films than just people being cut up," she says. "And I want people to see that."
The film starts just after 7:30 p.m. at Crash 45, 321 East 45th Avenue; admission is free. For more information, go to the Cruel Winter Horror Film Series Facebook page.
First Tuesday of every month, 7:30 p.m. Starts: Jan. 1. Continues through April 2, 2013
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- SIA Snow Show
Upcoming Events
Colorado Avalanche vs. Dallas StarsSat., Oct. 10, 7:00pm
University of Denver Pioneer Hockey vs. Air Force Falcons Mens HockeySat., Oct. 10, 7:05pm
Denver Brass: FantasiaSat., Oct. 10, 7:30pm
University of Denver (Du) Pioneer Women's Soccer vs. South Dakota State University WrestlingSun., Oct. 11, 12:00pm
- Tickets
- Screw Your Resolution Party


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Eden Village Motel and Cottages
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this motel rated in the past?
- Kitchenette
- Free parking
- Pets allowed
Travelers also recommend:
Historical Traveler Reviews Eden Village Motel and Cottages Bar Harbor
Wonderful, as always
I have stayed with Eden Village about a half dozen times over the last few years and always find it to be a great place. Bob and Gail are great, the cottages are always clean and well taken care of. You've got to love the little duck pond and it's in a great location for getting to and from both Acadia NP and Bar Harbor.
Eden Village was wonderful and we can't wait to go back!!
Eden Village is a wonderful place to stay. Our cottage was clean, well equipped and comfortable. Our dachshund Tasha was welcomed and she had an excellent time exploring the nature walk and the area around the pond. The fireplace in the cottage was a treat, as was the screened porch, and we enjoyed having a grill just steps from the cottage. The owners are friendly, knowledgable, and made us feel right at home. We hope to return next year. I highly recommend Eden Village!
Planning to return to Eden Village
We stayed for one week in both 2004 and 2003, in one of the cottages. Eden Village is a great value for your money, which is very important to budget minded families like mine.
The cottages were exceptionally clean and very comfortable. The kitchenette was equipped with everything we needed for our vacation meals.
Their location is excellent, right on Route 3, conveniently located to all Mount Desert Island has to offer. The cottages are set back far enough so that we hardly noticed the sound of passing vehicles. I found it to be very quiet and relaxing. We thoroughly enjoyed sitting on the enclosed porches first thing in the morning, and again in the evening after spending the day exploring the Island.
I highly recommend Eden Village. I am planning to stay with them the next time we visit the area.
The Perfect Spot
My wife an I have been vacationing in the Bar Harbor area for years.
We stayed at Eden Village for the first time, two weeks, in July 2004.
We rented one of their two bedroom cottages complete with fire place,
screened-in porch, bar-B-Q, patio table/chairs, cable TV and parking in front of the cottage. The bed was comfortable. The shower had plenty of hot water. The fridge kept things cold and all kitchen appliences worked perfectly, including the coffee maker, and plenty of clean towles. The electric heater puts out lots of heat when you need it for those cold nights. We enjoyed the peace and quiet during our stay at Eden Village with all the comforts of home. If your a smoker, don't worry. There are ashtrays and smoking is permitted inside the screen porch. The town of Ellsworth is just a short drive away for picking up supplies or buying a new car. Eden Village is clean, well maintained and
a pleasent place to stay.
Loved Our Vacation at Eden Village and Bar Harbor
We very much enjoyed our cabin and the hospitality provided by Gail and Bob at Eden Village. Coming from Daytona Beach, Florida, it was just what we hoped a vacation in Maine would be like--friendly people, terrrific fresh seafood, and homemade blueberry pies. We even lucked out with the weather. We were able to see a beautiful sunrise at the top of Cadillac Mountain at 4 a.m. We are definitely going to try to get back to Eden Village again. It was an incredible vacation.
Great Vacation Stay
My sister and I had a great week in June of 2004 while we stayed at Eden Village. The room was so clean and well maintained. The personnel were so helpful and friendly. The back patio for morning coffee and view of the mountains was surely a plus. The location was perfect for getting to Acadia National Park and other places in Maine quickly. I would return to Eden Village any and every time. Kudos to Gail for such a lovely place so well landscaped and maintained.
Gayle LaFleur - LaPorte, Texas.
A very nice place to stay
we are very satisfied with the service. will definitely stay there when we visit Bar Harbor again.
Wonderful place to stay
We were referred by friends who had stayed here, and we were glad for the reccomendation.
I did alot of research myself and found Eden Village to be about the best price-wise for what we were looking at.
The accommodations are modest but very clean and comfortable, which is what we care about. It is also quiet and set back off the road. The staff was very friendly and helped us out when we wanted to stay another night unplanned, even though it meant juggling rooms. They also gave us a good tip on which boat tour to take, which turned out very nice.
It's also very convenient location-wise to both Acadia park and town--I had wondered if it would be better to stay in town, but that would have been quite a bit more expensive and Eden Village worked out fine for us.
Hope you enjoy your time in Maine, we did!
Peaceful retreat
My mother and I needed a few days of what we call "ocean time". Both of us love Acadia and wanted a reasonably priced get-away to reconnect with the beauty of Mount Desert Island. Eden Village met all our needs with a spacious, clean, well-appointed room with a lovely rear deck, adequate kitchenette, and comfotable beds. We found the staff friendly and helpful. The grounds were lovely and scenic. It didn't have that "commercial" feel to it so we felt at home.
I am sure that one or both of us will return there in the near future!
Super-Clean and Family-friendly
Our cottage was just perfect--screened-in porch, fireplace, privacy. Everything was very, very clean. The kitchen was well-stocked. We
had 2 TV's (one for dad to watch baseball and one for the kids!).
The shuttle to town and to Acadia stops right in front of Eden Village.
The atmosphere is secluded and quaint.
TripAdvisor Reviews Eden Village Motel and Cottages Bar Harbor
Travel Blogs from Bar Harbor
A bit of Boston and Beautiful Maine
... we drove past had lobster cages stacked up in the yards.
Some maintenance is being done today (Friday, 6/26) on both our RVs (ours got new shoes -ouch!) and our persons (haircuts) in preparation ...
Baa Ha Ba
... a delicious Blueberry-tini, made with Maine blueberries.
Our hotel -Atlantic Oceanside- looks pretty snazzy from what we've seen. We have a little veranda, right on the waterfront. Only downside so far is that the wifi is ****; if this post goes through tonight, I'll be amazed! We have to have an early(ish) night tonight as Laura is fishing early tomorrow morning. 6am alarm call! Urgh... Goodnight! ...
The Good and the Bad of Bar Harbor
... North on US.1 along the Coastal route, and crossed the border at St. Stephen, NB. A very friendly border official provided a hassle free experience for our seamless entry back into Canada. Yahoo!! Eh! Our plans to stay in St. George for only one night got changed by Hurricane Arthur, we decided that caution was the order of the day, so we decided to stay another night, albeit with no electricity. We also upgraded to a beautiful room with a jacuzzi, ahhhhh!!! and the rest as they say.... ...
Acadia National Park Travel Review
Acadia National Park, Mount Desert Island, Maine
Type of Attraction: National Park in the Great State of Maine
Reviewer: Lauren Doolittle
Date of Visit: November 9, 2013
There are many beautiful places to visit in Maine, but nothing quite beats Acadia National Park. Located on Mount Desert Island. The State of Maine is full of all different types of tourist attractions, ...
The lobster story
... one of the crew standing out the front for an extra pair of eyes was completely soaked – we were nice and dry with a roof over our heads. Most of Scenic together for farewell to the ship dinner – before sweets the whole (well most I guess) of the crew paraded around the two dining levels to rousing music and a serviette waving thank you and ...