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Our clients come to us with the worst kind of problems and we solve them—with creative, focused, determined advocacy.
We defend.
Our firm was founded in Ottawa by a group of hungry young criminal lawyers who believed that every one of our clients deserved a smart, creative, fearless defence.
We still believe that. And we have now matured into the largest criminal-law boutique in Eastern Ontario, and one of the largest specialist criminal-law firms in the country. None of us works alone. Our entire firm stands shoulder-to-shoulder with each client. There is strength in our size.
Our clients.
As we have grown, our lawyers have been sought out by clients from across Ontario, and from all walks of life. We represent executives, civil servants, doctors, pharmacists, high-tech workers, and diplomats. Our clients also include institutions and organizations facing criminal or regulatory issues.
But we also believe quality representation should not only be available to those who can easily afford it. Because of our size, we have the flexibility to accommodate clients who might otherwise struggle to pay for top-flight legal representation. And, in appropriate cases, we accept Legal Aid.
Our cases.
We have what it takes to defend any criminal charge, regulatory infraction, or disciplinary offence. White-collar crime. Drugs. Crimes of violence. Driving offences, including impaired driving. We provide specialized representation at all stages of litigation. We give counsel to individuals and institutional clients about their legal responsibilities. And we represent people who have been charged: obtaining bail, at trial, and on appeal.
Our reach.
We have offices in Ottawa and Cornwall, and we regularly appear in Gatineau and Eastern Ontario, including Brockville, Kingston, L'Orignal, Pembroke, Arnprior, Perth, Smiths Falls, Alexandria, and Morrisburg.
But our reach doesn't end there. We are often sought out by clients elsewhere, including Toronto, Guelph, Sarnia, Thunder Bay, and beyond.
Our approach.
In our business, there is such a thing as being too nice. We never lose sight of the fact that a prosecution is always personal—someone is trying to take away your reputation, your future, your freedom. We respect our adversaries, but we never forget that we are there to protect our clients, not to make friends.
A custom-crafted defence.
Beware the cookie-cutter defence. Every client is different. Every case is different. We get to know our clients and we spend the time to find out what approach will work them.
And we know the simple things count. We will return your phone calls. We will keep you up-to-date on your case. And we will get to know you and your goals as we craft our strategy and your defence.
Criminal Trials
We are trial lawyers.
In a criminal trial there is no room for mistakes. It's under that kind of pressure that we do our best work. Judge or jury. Murder trial or impaired driving charge. Cracking open a tough witness or advancing a complicated legal argument. The courtroom is our comfort zone. We believe there are no impossible cases.
Discrete Lawyering
Keeping a lid on criminal charges.
You need to have a touch of showmanship in your blood to love jury litigation, and we're always pleased to have a big win splashed across the newspapers. But a big part of the work we do is out-of-court lawyering—negotiating, cajoling, convincing. Turning big cases into little ones, and making little ones go away entirely. You won't see these cases in the newspaper. Now, we like being in the news, but we find that many of our clients prefer to get a great result and skip the media attention. We're happy to oblige.
It ain't over till it's over.
The worst words a criminal defendant can hear from a judge or jury: guilty as charged. We have brought countless clients back from that abyss. Clients convicted of all kinds of offences have put their faith in us to deliver the just result they were denied at trial. Few firms have the experience, and or have had the success, that we have had in the Court of Appeal and the Supreme Court of Canada.
Federal victim surcharge bound for Supreme Court, defence lawyers sayOTTAWA – Defence lawyers say mandatory victim surcharges being imposed on destitute offenders are destined for the Supreme Court of Canada as fierce legal battles play out in lower courts in British Columbia and Ontario. The latest skirmish is taking place in B.C.'s provincial court, where the Crown is expected to argue next month that the surcharge is a reasonable limitation of a homeless offender's Charter rights. Trial judge Donna Senniw has already determined the man's rights, outlined under sections 7 and 12, were violated. […] Many judges across the country felt the mandatory surcharge removed their sentencing discretion and some tried to find ways to circumvent the surcharge, such as setting lengthy payment schedules. "The response we have seen from the judiciary has been exceptional," said Ottawa criminal lawyer Michael Spratt. "The reason why the judges, I think, are finding creative ways to try and bring fairness back into the system is because these are the people who hear and see the homeless individual who has no money, who is faced with what can be, for them, a back-breaking fine for minor offences." Read Kirsty Kirkup's full article: Canadian... read more
CSIS needs 'warning system' on risk of torture, lawyer saysRestoring the inspector-general's position at the Canadian Security Intelligence Service could help monitor instances when the agency relies on assurances from foreign governments that a person of interest to Canada won't be tortured, according to Ottawa human rights lawyer Paul Champ. He made the comments following revelations that Canada's spy agency was given the green light to send information to an allied foreign agency about a terrorist target of mutual interest and interview a Canadian detained abroad, provided assurances were obtained that both individuals would face "no substantial risk of mistreatment" abroad. […] Ottawa criminal defence lawyer Leo Russomanno, co-counsel for Algerian-born Mohamed Harkat, who last year lost his Supreme Court of Canada challenge to have the security certificate used to detain him for nearly four years declared unconstitutional, said the federal government relied on assurances from its Algerian counterpart that Harkat wouldn't be mistreated despite reports from Human Rights Watch and Amnesty International that the risk of that happening were high. "Torture isn't just occurring in the far corners of the globe — it's happened with the U.S. military at Guantanamo Bay, at CIA black sites in Europe and when Canadian soldiers transferred prisoners to Afghan authorities, who then tortured them," said Russomanno, whose practice at Abergel Goldstein & Partners is focused in part on national security law. "At what point do we start acting like adults, and follow our Constitution and international human rights obligations and stop getting carried away in this cycle of fear over this existential threat of terrorism?" Read Christopher Guly's full article: The Lawyers'... read more
Placing Del Mastro in handcuffs, leg irons standard procedure: OPPTransporting convicted MP Dean Del Mastro to jail in handcuffs and leg irons was standard operating procedure used for everyone from fraudsters to serial killers, the Ontario Provincial Police said Friday. The image of Del Mastro, Prime Minister Stephen Harper's former parliamentary secretary, shuffling out of the courthouse in Peterborough, Ont., appeared to rattle political observers who seldom witness the gritty day-to-day workings of the criminal justice system. Michael Spratt, a criminal lawyer with Abergel Goldstein and Partners LLB in Ottawa, said Del Mastro's treatment is "standard practice." "It's another example of sort of a one-size-fits-all solution to perceived problems in the justice system," said Spratt, a frequent and trenchant critic on social media of Conservative "tough-on-crime" policies. Read Bruce Cheadle's full article: CTV... read more
Conservatives spend almost $7M defending unconstitutional legislationOTTAWA —The Harper Conservatives have spent no less than $6.5 million defending high profile and contentious pieces of legislation ultimately deemed unconstitutional, recently disclosed documents show. But that sum only tells the beginning of the story, said one criminal defence lawyer. The $6.5 million price tag was arrived at after Liberal MP Scott Simms asked six ministers to release how much they'd spent fighting 16 specific constitutional court challenges. The government lost each of the challenges at various levels of court, said Michael Spratt, partner at Abergel Goldstein & Partner in Ottawa. "But they do not represent all the losses," he said. "That is the tip of the iceberg for this government defending Read Amy Minsky's full article: Global... read more
Ottawa street checks are the 'wild west,' lawyer saysA local criminal defence lawyer believes the police practice of doing street checks in Ottawa is worse than in it is in Toronto. "In Toronto you had the mayor weigh in on it, you had the Toronto police services board actually try to implement some sort of policy and rule about it," Michael Spratt said Tuesday. "In Ottawa, it's the wild west, there are no rules, and it's a practice that's rampant here as well." Ottawa police have been building a street check policy and they plan to present it to the board when the proposed guidelines are ready. The province announced Tuesday it wants to standardize a street check policy across Ontario police forces. Spratt said a street check policy should require police to inform people what their rights are. Read Jon Willing's full article: Ottawa... read more
Ottawa drug-trafficking case collapses in entrapment rulingUntil the other week, Ramy Yasso was a convicted Vanier crack dealer. He now has a new lease on life after an Ontario Superior Court justice tossed out his drug-trafficking conviction. Justice Gary Tranmer ruled that a police undercover buy of $60 in crack amounted to entrapment in law because officers gave Yasso an opportunity to commit the crime without any reasonable suspicion that he was already engaged in drug trafficking. Read Gary Dimmock's full story: Ottawa... read more
Human and financial costs of drug war just too highBy Michael Spratt Michael Swan was watching Canada play the United States for Olympic hockey gold while the three young men who would kill him were driving to Ottawa down a dark highway. The "Toronto three", as they would come to be known, had a plan to make some easy money: They were going to steal Swan's marijuana. Swan was murdered later that night on Feb. 21 2010 — killed by a single bullet that pierced his lung and tore apart his heart. Swan's life was taken for a small amount of marijuana; as were the lives of Travis Votour and Amanda Trottier — killed in January 2014, allegedly in a marijuana drug rip, as was the life of Yazdan Ghiasvand Ghiasi, who apparently died over a bag of weed in 2010. This is the result of the failed war on drugs. A year ago, the Global Commission on Drug Policy released a report entitled Taking Control: Pathways to Drug Policies That Work. The report provided a substantive analysis of current global drug policy. The Commission was comprised of international experts, former presidents and prime ministers, and former Supreme Court of Canada justice Louise Arbour. At its core, the commission's report emphasized that a fundamental shift in policy — health, social and criminal — was required, to alleviate the harms associated with drug use. The report was unequivocal: The world's war on drugs has been an abject failure. As a criminal defence lawyer, this comes as no surprise. Every day I see the ravages of illegal drugs in our communities. Canada has a drug problem, but it is a... read more
Its Time to Get Smart About Crime
The streets of Old Ottawa South have never been more dangerous. Convicted murders roam free, pedophiles lurk behind every bush, and our children are in constant danger. This is not our parent's neighbourhood; we live in dark and dangerous times.
Of course none of that is true. The despotic image of dangerous, crime-ridden neighbourhoods only exists in the imagination of the tough-on-crime Conservatives. Given the Harper government's track record on real issues – say the environment or the economy – the crime narrative is a necessary fiction, an exercise in distraction, which has little to do with increasing public safety.read more
The Use of Phallometric Evidence in Canadian Criminal LawJournal of the American Academy of Psychiatry the Law Michael S. Purcell, JD, Jennifer A. Chandler, LLB, LLM and J. Paul Fedoroff, MD Abstract The use of phallometric evidence by Canadian criminal courts has steadily increased since the early 1980s. Phallometry was initially considered by courts to be a potentially useful tool in the determination of accused persons' culpability; however, its contemporary use is limited to the postconviction contexts of sentencing and dangerous and long-term offender applications, as one of several means of diagnosing offenders, determining recidivism risk, and assessing treatment prospects. We provide an overview and assessment of the use of phallometric evidence by Canadian criminal courts and conclude that its contemporary application appears to be consistent with the expert psychiatric consensus on its proper role and function in the forensic context. We further identify potential difficulties associated with the adequacy of offenders' consent and the occasional divergence of expert opinion about the reliability and validity of phallometry for diagnosis and risk assessment. Phallometry (also known as penile plethysmography) is a technique used in the assessment and treatment of paraphilias in men. In essence, it detects an increase in penile circumference in response to specific visual or auditory stimuli and, on this basis, suggests the nature of the subject's sexual interests. Analogous techniques have been developed to assess women. We note also the recent exploration of functional magnetic resonance imaging to assess sexual interests. Phallometric evidence has been accepted by courts in the United States as a condition of parole, probation, and supervised release; however, there has been much greater resistance to admitting it at trial. Although phallometry has now attracted a significant level... read more
Carding, not just a Toronto problemCarding happens everywhere, not just in Toronto. Police officers routinely ask individuals for identification when they are not suspected of criminal activity. It happens on the street, and it happens to passengers in vehicles. It happens across the country. While it is laudable that the Mayor of Toronto has vowed to end the policy of carding there, it would be naive to think that this signals an end to carding at large. The practice and injustice of carding has long predated the Toronto Police's policy. Like all other Charter violations, when carding doesn't lead to criminal charges, it never comes to light. Thanks to the Toronto Police's official policy of carding, we know that it has been used to disproportionately target racial minorities. The practice of carding is offensive enough, it is even worse when it disproportionately affects minority groups and the poor. Here's a shocker: some people, including police officers, are racist. Lower income neighbourhoods are also subject to greater police oversight. So it really should come as no surprise that racial minorities and the poor are bearing the brunt of the police's disrespect for the law. It is also apparent that but for criminal charges being laid, the public or the administration of justice would never become aware of this practice. So until the Toronto Police decided to make it an official policy, carding had largely fallen under the radar. It is emblematic of all individual rights that those who are charged with criminal offences serve as proxies for those of us who are never charged. I suppose we have the brazenly illegal policy of the Toronto... read more
Bail: the presumption of guiltThe presumption of innocence shouldn't be banal cliché. But that is what it is becoming. In Canada the presumption of innocence is under attack and the right to reasonable bail is the current battleground. Of the tens of thousands of inmates in Canadian jails almost 60% have yet to be convicted. These are real people – people with homes and families, people with serious medical or mental health issues, people who often could otherwise still form a part of our society. Many of these people should not be in custody. All of these people are presumed innocent. The presumption of innocence is so important that not only is it found at the beginning of the Criminal Code of Canada, but it is also part of the supreme law of Canada: The Charter of Rights and Freedoms. As part of the right to be presumed innocent until proven guilty, the Charter guarantees reasonable bail. Shockingly, the current bail system is anything but reasonable At trial, if the government wants to take away your freedom, it needs to prove that you did something wrong beyond anyone's ability to reasonably doubt it. This is a high burden – but the Crown should have a heavy burden when liberty is at stake. But bail court isn't trial court. You may think that before an accused is found guilty it would be harder to lock them up – you would be wrong. At a bail hearing there are few rules to protect an accused – everything about a person's character, prior calls to the police, rumours, and even unfounded allegations can be considered. All to often an unrepresented accused... read more
Crowdfunding constitutional litigation of retroactive pardon limits
In March 2012, the Harper government's massive crime bill, Bill C-10, became law. This bill severely limited the availability of house arrest, imposed mandatory minimum sentences, required harsher treatment of young offenders, and increased the waiting periods for pardons.
One of our clients was impacted by the retroactive pardon changes. Just before he was eligible under the old rules to apply for a pardon, he was told that he would have to wait another five years.
Abergel Goldstein & Partners is assisting M.C in his plan to challenge the retroactive pardon elegibility changes in Bill C-10.read more


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Brave boy Hayden Tingey killed walking brother home
HAYDEN Tingey was a little big brother with an equally big heart.
HAYDEN Tingey was a little big brother with an equally big heart.
I KNOW I'M NOT AUSTRALIAN BECAUSE……… 1. I think koala bears and kangaroos are cute, not annoying. 2. I find it bizarre when everyone is nice and smiling and therefore automa...
A SIZE eight teenage model said being bullied for being too fat on Australia's Next Top Model sent a dangerous message to vulnerable young viewers.
Brazil Whoever came up this idea should be given some sort of creative award. In this set, 12 different countries are represented by their respective flags. T…
A foreign doctor who moved to rural WA to help fill the skills shortage, and now wants permanent residency, has been told he cannot stay in Australia unless he divorces his dying wife.

subset: commoncrawl


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Funny Or Die
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Hawkeye Videos, Hawkeye Pictures, Hawkeye Articles
The Damon Legacy (Bourne Parody)
There was never just Matt.
The Bourne Misunderstanding
Jason Bourne has a little trouble understanding exactly what people are saying to him.
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Brian has several unanswered questions about 'Avengers: Age of Ultron' — specially what happened to his dad.
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A hard boiled detective faces his toughest assignment yet! www.joeclarkecity.com www.kungfugraffiti.com -- link to my first feature film page
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Two Chins review The Avengers
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NBC's Newset Flop...Goodbye, Farewell and Amen.


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Select Local Merchants
Jersey DanceRead More"No matter what you do with your dancing always be sure of one thing," writes Jersey Dance owner Jennifer in her dance blog. "The process of learning to dance should be the most enjoyable part." The longtime competitive dancer lives and teaches by that principle, as does her team of instructors. Their nonjudgmental vibe pervades the studio, creating a space where soonlyweds can get help choreographing their wedding dance from an encouraging professional. Likewise, groups of beginners can experience the thrill of learning the steps they see on dance-competition shows while skipping the part where they're given scores and spanked by the ghost of Fred Astaire. One-on-one sessions, meanwhile, offer private pointers on the complexities of the quickstep, the dagger-sharp footwork of Argentine tango, or enough floor space to safely attempt West Coast swing at its jitterbuggiest. Whatever is being taught that week, Jennifer and Co. tailor in-studio socials that give dancers a party setting to show off everything they've learned.357 Applegarth RoadMonroe Township, NJ US
Yogi's All American Grill and Sports BarRead MoreA well-known bar in Monroe Township, Yogi's is the ideal location for terrific pizza. It's a popular restaurant for customers that want a helpful staff and delicious food. It should be noted that business casual is the recommended attire. It's been tabbed as a nice option for both families with children and large groups. WiFi is available if you want to get some work done, and it offers convenient local delivery, and can even cater events in the area. Or, if you're looking for a good spot to hit up after work, it's got a popular happy hour and pretty decent selection at its bar. When you put it all together, making a trip to Yogi's is never a bad call. Don't worry about trying to find a spot on the street, as visitors to the restaurant do have access to a private parking lot nearby. Should you prefer to pedal over there, bicycle parking's also provided.390 Forsgate DrMonroe Township, NJ US
Hedy's Super Discount LiquorRead MoreFeaturing fresh and flavorful American food, Hedy's Super Discount Liquor is a local favorite. Hedy's Super Discount Liquor does not prepare their menu with low-fat items, though, so those following a strict diet may have better luck elsewhere. The restaurant also offers catering if you want to bring the flavors of Hedy's Super Discount Liquor to your next party or event. Don't waste time searching for parking, we've done all the work for you. Spaces available here. For a decently-priced meal that's not too fancy, Hedy's Super Discount Liquor hits the nail on the head.500 Mercer StHightstown, NJ US
Multiplex CinemasRead MoreWatch your heart out when you see all of the amazing movies at Multiplex Cinemas in East Windsor. Service and taste make a great restaurant, and that's why you won't be disappointed by this theater. Both the young and the young-at-heart will dig the family-oriented activities and atmosphere at this theater. Check out what movies are playing at the drive-in theater! Parking is plentiful, so guests can feel free to bring their vehicles.319 US Highway 130East Windsor, NJ US
Whitlock TavernRead MoreVisit Whitlock Tavern for some true American comfort food. None of the fare at Whitlock Tavern is low-fat, so you'll have to put the diet aside for a visit here. Endless parking options are readily available close to Whitlock Tavern. No matter what you choose off the menu at Whitlock Tavern, you won't completely break the bank with prices averaging around $30.375 Georges RdDayton, NJ US
David's Pub and PackageRead MoreEnjoy a large array of finger food at David's Pub and Package, a local pub. David's Pub and Package is crafting dishes with only the best ingredients. Come hungry and leave happy. Take your vehicle to dinner nearby parking is plentiful and will not pose a problem for drivers looking to dine. Prices are affordable, with a typical meal running under $30.659 Abbington DrEast Windsor, NJ US


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28 Apartments for Rent in San Luis Obispo, CA
Of the 28 apartments in the Santa Barbara metro, we found exactly 1 apartments for rent in San Luis Obispo and 8 apartments nearby. Refine your search by using the filter at the top of the page to view 1, 2 or 3+ bedroom apartments for rent in San Luis Obispo as well as cheap apartments, pet friendly apartments, apartments with utilities included and more. Use our customizable guide to refine your options for apartments in San Luis Obispo and find exactly what you want during your San Luis Obispo, California apartment search.
Bordeaux House Apartments9309 Bocina Lane Atascadero, CA 9342235.455603 -120.636636- Near San Luis Obispo, CA+−Preview DetailsCollapse Details
Bordeaux House Apartments, located in Atascadero, CA, offers spacious two bedroom apartments tucked away in a private, comfortable setting...yet, close to shopping, entertainment, and public transportation. Relax by the pools in the park like setting.
- Sparkling Pools & Spas
- Children's Playground
- Fitness/Weight Room
- Lighted Covered Parking
- Short Term Leases Available
- Water, Sewer and Trash is Paid
- Dishwashers
- Ceiling Fans
- Central Heat & Air
- Laundry Facilities
- Frost-Free Refrigerators
- Professional Management Team
5896 Birkdale Lane5896 Birkdale Lane San Luis Obispo, CA 9340135.21723 -120.62383
2825 Pecho Valley2825 Pecho Valley Los Osos, CA 9340235.30189 -120.86106
270 Ocean Oaks270 Ocean Oaks Avila Beach, CA 9342435.18151 -120.73148
423 Westpoint423 Westpoint Pismo Beach, CA 9344935.15679 -120.66519
464 Stimson464 Stimson Pismo Beach, CA 9344935.14167 -120.63629
393 Wadsworth393 Wadsworth Pismo Beach, CA 9344935.14379 -120.64272
2614 Adobe Road2614 Adobe Road Morro Bay, CA 9344235.35614 -120.78843
881 Taft Street881 Taft Street Pismo Beach, CA 9344935.14968 -120.6385
To see more Apartments, try broadening your search.


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Type: Post | Date: Tuesday, Sep 2, 2014TBS canceled CeeLo Green's TBS reality show before his Twitter rape comments controversy "Unauthorized Saved by the Bell" brings in a disappointing 1.6 million viewers "Utopia" contestant sent to the hospital


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Future Megacities - Water Management in Lima, Peru
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Innovations in Smart Buildings
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Presented at the Experimental Biology Symposium Activity-Dependent Plasticity in Central Homeostatic Systems, San Francisco, USA, April 2006.
Article first published online: 23 FEB 2007
DOI: 10.1111/j.1440-1681.2007.04590.x
Clinical and Experimental Pharmacology and Physiology
Volume 34, Issue 4, pages 377–384, April 2007
Additional Information
How to Cite
Mueller, P. J. (2007), EXERCISE TRAINING AND SYMPATHETIC NERVOUS SYSTEM ACTIVITY: EVIDENCE FOR PHYSICAL ACTIVITY DEPENDENT NEURAL PLASTICITY. Clinical and Experimental Pharmacology and Physiology, 34: 377–384. doi: 10.1111/j.1440-1681.2007.04590.x
Publication History
- Issue published online: 23 FEB 2007
- Article first published online: 23 FEB 2007
- Received 14 June 2006; revision 17 November 2006; accepted 5 December 2006.
- Abstract
- Article
- References
- Cited By
- cardiovascular disease;
- exercise;
- physical inactivity;
- sympathetic nervous system
- 1It has been generally accepted that regular physical activity is associated with beneficial effects on the cardiovascular system. In fact, the idea that exercise maintains cardiovascular health is evident by the direct links between a sedentary lifestyle and the risk of cardiovascular and other disease states.
- 2Cardiovascular diseases, such as hypertension and heart failure, are often associated with sympathetic nervous system (SNS) overactivity. Conversely, exercise has been shown to reduce hypertension and decrease elevated SNS activity. In addition, there is evidence that exercise may reduce resting blood pressure and sympathetic outflow in normal individuals.
- 3Although somewhat controversial in humans, evidence from animal studies also indicates that exercise training reduces baroreflex-mediated and other forms of sympathoexcitation in normal individuals. Collectively, these data are consistent with the hypothesis that physical activity may decrease, and physical inactivity may increase, the incidence of cardiovascular disease via alterations in SNS activity. Despite the important clinical implications of this possibility, the mechanisms by which exercise alters control of SNS activity remain to be fully elucidated.
- 4Recent evidence suggests that central nervous system (CNS) plasticity occurs under a variety of conditions, including varying levels of physical activity. The purpose of the present brief review is to provide evidence that changes within the CNS contribute importantly to altered regulation of the SNS observed following exercise training. The primary hypothesis is that physical activity versus inactivity produces plasticity within neural networks that regulate SNS activity. This hypothesis is supported by published and preliminary data that suggest that exercise training may reduce sympathoexcitation by reducing activation of neurons within cardiovascular regions of the brain. These mechanisms are likely to be important in disease states of sympathetic overactivity and in normal healthy individuals whose risk of cardiovascular disease is reduced by leading an active versus sedentary lifestyle.


text:
js2211b1.jpg (534×688)
Art Illustrations, Okada Yoshio, Artsy Gorgeous, Japan Art, Bijin Dreams, Art Collection, Asian Art, Japan Illustrations, Oriental Art
Katsushika Hokusai. #art #illustration #japanese #girl #beautiful
Bijin Dream, by Okada Yoshio.
Ikenaga Yasunari The Japanese Art of Nihonga Redefined inspiration
Ikenagayasunari, Illustrations, Japan Paintings, Yasunariikenaga, Yasunari Ikenaga, Portraits, Bohemian Tapestries, Ikenaga Yasunari, Textiles Patterns
Portraits of Women by Ikenaga Yasunari :: koikoikoi.com - Visual Arts Magazine, graphic design, illustration, photography, interviews, inspiration, tutorials
Portraits of Women by Ikenaga Yasunari Ikenaga's paintings also showcase exquisite textile pattern designs. His subjects are always women of modern times, but at the same time, the Nihonga painting style reflects ancient Japanese traditions, which gives his works a timeless feel. He creates his art by dropping Japanese paints into the canvas that he calls "linen cloth", with a Menso brush.(model Makiko)
Las Calles Hablan on Vimeo
Street Artists, Art Documentaries, Community Paintings, Artists Community, Art Streetart, Vimeo Art, Art Callejero, Artists Themselv, Las Call
We wanted to make a documentary which was filmed mostly on the streets, shot from the hip, something that reflects the street art itself. A lot of the story comes from the street artists themselves. They were always generous with their time and information. They developed the process, they wanted this story to be told. Las Calles Hablan is a story about discovering a hidden world, an extraordinary subculture and the struggle between an artistic community painting for freedom of expressi…
Las Calles Hablan via Vimeo #art #streetart
Las Calles Hablan Barcelona street art documentary. Read more here - http://www.homagetobcn.com/barcelona-street-art-documentary/.
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French Artists, Artists Charlotte, Animal Head, Illustration, Charlotte Caron, Mixed Media, Animal Masks, Paintings, Animal Portraits
Acrylic Animal Portraits on Photos by Charlotte Caron in Illustration
These amazing painted animal masks on photographic portraits are the work of French artist Charlotte Caron.
Work of French artist Charlotte Caron. Contemporary, mixed media, painting, photography
French artist Charlotte Caron. This combination of photography and illustration creates the illusion that the colourful animal heads drawn are the characters alter egos.
grosman-marcelo-guilty.jpg (787×1181)
7871181, Grosmanmarceloguiltyjpg
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Mario Ucci
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Digital paintings -Mario Ucci
This Pin was discovered by Jeff Wrench. Discover (and save!) your own Pins on Pinterest. #bizarre #art #bizarreart #creepy #strange #eerie #darkart
Mark Horst
Weights Loss Program, Secret Life, Amazing Weights, Oil On Canvas, Mark Horst, Weightloss Program, Weights Loss Tips, Weight Loss Tips, The Secret
markhorststudio: "mark horst, "the secret life no. 9" oil on canvas, 24" x 48", oil on canvas, 2012 "
Mucha Inspired
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NOTRE-DAME-DE-GRÂCE- Art Nouveau Wall Mural in Montreal | Salty Sea Dog
Street Art Nouveau
Paul Klee(1879-1940) - "Young Proletarian" (1916)
Proletarianpaul Klee, Art Paul Klee, Young Proletarian, Klee Stunning, Artists Paul, Klee 1879 1940, Klee Museums, Klee Paul, Proletarian Paul Klee
Klee, Paul (1879-1940) - 1916 Young Proletarian (Klee Museum, Berne, Switzerland) by RasMarley, via Flickr
Paul Klee Stunning
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Thumbnail for version as of 14:50, 21 January 2005
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Carowie Szujscy na sejmie warszawskim Jan Matejko 18 century - Zygmunt III Waza –
1612 - Russian obeisance to polish king Zygmunt III WASA
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Agent Murders, False Dmitri, Mothers 1862, Konstantin Makovski, Murders Feodor, Feodor Godunov, Fal Dmitri, Dmitri Agent, Russian History
Konstantin Makovsky -False Dmitrys agents murdering Feodor Godunov and his mother 1862
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Cossack Writing, Ilya Repin, Art, A Letters, Turkish Sultan, Efimovich Rap, Ottomans Empire, Zaporozhian Cossack, Paintings
The Zaporozhian Cossacks write a letter to the Sultan of Turkey, by Ilya Repin (1844–1930), oil on canvas, 6'x11', 1880-81, State Russian Museum, St. Petersburg. The story told in this painting is of a group of Cossacks writing an insulting and profane reply to the Turkish Sultan who demanded that they submit to Turkish rule.
"Запорожские казаки пишут письмо турецкому султану" И.Е.Репина / "The Zaporozhian Cossacks write a letter to the turkish Sultan" by Il'ya Efimovich Repin (5 May 1844 - 29 Sep 1930)
The Zaporozhian Cossacks write a letter to the Sultan of Turkey, detail (1880–1891). Ilya Repin (Russian, 1844–1930). Oil on canvas. State Russian Museum. The Sultan of the Ottoman Empire, Mehmed IV, demanded that the Cossacks submit to Turkish rule. The Cossacks, led by Ivan Sirko, replied in an uncharacteristic manner: they wrote a letter, replete with insults and profanities. The painting exhibits the Cossacks' pleasure at striving to come up with ever more base vulgarities.
repin paintings | ilya repin art
REPIN_Ivan_Terrible (1200×877)
1581, Repin Ivan, Ilya Repin, Art, Terrible, 1885, November 16, Sons Ivan, Paintings
Ilya Repin, Ivan the Terrible and his Son Ivan on November 16, 1581, 1885. #art #artist #painter #painting #paintings #arthistory
Ivan_the_Terrible_(cropped).JPG (726×909)
Ivan Iv, Historical Tidbit, Tsarivan, History Humor, Russia History, Cold War, Tsar Ivan, Russian History, Russian Czar
Tsar Ivan IV The Terrible Vasilyevich Rurik (25 Aug 1530-28 Mar 1584) 1st ruler to be crowned as Tsar of All the Russians at age 16. Historic sources have different accounts of Tsar Ivan IV The Terrible's complex personality: he was described as intelligent & devout, yet given to rages & episodic outbreaks of mental illness that increased with his age.
Andrew Salgado; Oil, "Bewildered Pursuit"
Bewild Pursuit, Andrew Salgado, Oil Paintings, Artists, Modern Art, Art Paintings, Oil On Canvas, Saatchi Online, Andrewsalgado
Andrew Salgado / The Bewildered Pursuit, 2012 / Oil on canvas / 140x190cm
Saatchi Online Artist: Andrew Salgado; Oil, Painting Bewildered Pursuit
Andrew Salgado modern art painting This painting is so beautiful! I would love to hang it up in my house!!
the bewildered pursuit, painting by andrew salgado, 2012 #art #painting #andrewsalgado
klimt-obra: Egon Schiele, liegendes halb bekleidetes Mädchen. 1911
Drawings, Be Shiel, Art Paintings, Illustration, Semi Nud Girls, Arthur Schnitzler, Seminud Girls, Egon Schiele, Egon Schiele
Egon Shiele
#art #painting Egon Schiele, Semi-Nude Girl, Reclining, 1911.
Egon Schiele - Seminude girl, Reclining
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Egon Schiele. "Liegen Frau mit der roten Hose und Weiblicher Akt", 1913. #egonschiele #art #painting #expressionism #figurative
Egon Schiele, Liegende Frau im gelben Keid (Lying woman with yellow dress), 1914 via upload.wikimedia.org
Gelbem Kleid, Yellow Dressliegend, Yellow Dresses, Recliners Women, Lie Women, Egon Schieleliegend, Dressliegend Frau, Kleid Recliners, Dresses 1914
Egon Schiele, Liegende Frau In Gelbem Kleid (Reclining Woman In Yellow Dress), 1914
deadpaint: Lying woman with yellow dressLiegende Frau im gelben Keid Egon Schiele 1914
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Egon Schiele. "Liegen Frau mit der roten Hose und Weiblicher Akt", 1913. #egonschiele #art #painting #expressionism #figurative


text:
Live updates
Police appeal after wheelchair is stolen in Skegness
Police are appealing for witnesses after an elderly lady's wheelchair was stolen in Skegness.
The wheelchair was stolen from the lady's garden, in York Way between 11am on Friday 27th March and 9am on Monday 30th March.
Anyone with information has been asked to contact police.
Meeting to discuss future of Skegness Pier Field
A public meeting will be held tonight to discuss the future of Skegness' Pier Field site. Ideas include building an amphitheatre stage, dubbed 'The Shell'. The council designated the area an 'Asset of Community Value' after residents opposed plans to sell it for a hotel development. The meeting will be at the resort's Grosvenor House Hotel.
Ryan Smith has honour of re-opening Skegness leisure park
A Lincolnshire teenager who was left with a life threatening brain injury following a cycling accident, has been given the honour of re-opening Skegness' leisure park Fantasy Island. Ryan Smith's family have been campaigning to make bicycle helmets compulsory, and this year their charity will be backed by the resort. Victoria Whittam reports.
- ITV Report
Three tiger cubs are bedding in at Skegness zoo
Zoo keepers say tiger trio are getting bolder by the dayRead the full story ›
Contentious land listed as community asset by council
A piece of land that has been at the centre of a debate on Skegness seafront has now been listed as an asset of community value by East Lindsey District Council.
The council has also put Pier Field on to the open market meaning campaigners now have six weeks to express their interest in acquiring it.
They would then have six months to submit a bid to purchase the site.
Developers who wanted to build a Major hotel chain on the land would also be able to bid though as part of the process.
Council blocks controversial Skegness hotel development
Controversial plans to build a hotel on Skegness seafront have tonight been blocked by East Lindsey Council.
Sorry, this content isn't available on your device.
Developers wanted to buy the Pier Field site to build an 80-bedroom Premier Inn and fast food restaurant.
But campaigners wanted it to be registered as a so-called "community asset".
This evening the council decided not to sell the site to KCS Developments, but have instead opened it up for sale to other groups.
They now have six months to put in bids before the council reconsiders its decision.
Five men charged after two men injured in Skegness
Five men have been charged with aggravated burglary after an incident which left two men injured - one is critically ill.
Police were called to an address on South Parade in Skegness on Saturday. The five arrested - all from West Yorkshire - were stopped later on the A16 near Burwell.
They will appear at Lincoln Magistrates today.
Detectives continue to question five men over Skegness attempt murder
Detectives are continuting to question five men who have been arrested on suspicion of attempted murder .
Police were called to an address on South Parade in Skegness on Saturday where they found two injured men.
They were taken to hospital where one is a critical condition. The five men were arrested later on the A16 near Burwell.
Skegness' Pier Field site future to be decided
The future of a piece of land at the centre of a planning battle in Skegness should be decided at a meeting tonight.
Developers want to build an 80-bedroom hotel and fast food restaurant on Pier Field. Campaigners want it to be registered as a 'community asset'.
Five arrested following Skegness attempted murder
Five men in Skegness have been arrested on suspicion of attempted murder.
Police were called to an address on South Parade in the town at around 4:30pm on Saturday where they found two injured men, aged 18 and 23.
Both were taken to hospital where one was later discharged, but the other is in a critical condition.
The five men were arrested after a silver Ford Focus, believed to have been connected with the attempted murder was stopped on the A16 at Ulceby Cross.
The Senior Investigating Officer DCI David Rimmer said:
This was a brutal attack for which the motives are currently unclear. Although we have arrested suspects I am appealing for anyone who may have witnessed anything that may be connected to this incident either on South Parade, Skegness or on the A16 yesterday in the late afternoon.


text:
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Notepad++ project is moving to GitHub:519 weekly downloads
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text:
Organic growth, after restatement for foreign exchange effects stood at 13% over the quarter and 12% over the full year.
As a consequence, results for the year will markedly improve: operating profit and net profit as a percentage of sales should remain close to the levels achieved in 2008 (16% and 11%, respectively). The Company had a positive net cash position at the end of the financial year.
The comprehensive 2009 results will be published on 16 March 2010 after close of trading.
As for 2010, the Group is currently expecting significant growth and a further improvement in its results due to the limitation put on R&D expenses.
Significant 4th quarter transactions and events
Following the mutual recognition procedure, Oralair(R) (immunotherapy tablet for grass pollen) was granted a marketing authorisation in 22 European countries in its adult and paediatric indications on 27 November 2009.
The outstanding results of the study devoted to showing the long-term sustained effect of Oralair(R) were announced on 7 December 2009. They significantly confirmed the clinical relevance of Oralair(R). This study is being continued with a view to demonstrating the persistence of the effect after completion of the treatment (carry-over effect), which should be the subject of an announcement at the end of 2010.
The Oralair(R) phase III clinical study in the US was completed in good conditions. Talks are ongoing with the FDA on statistical analysis matters. These exchanges have no impact on the results of the study but must be concluded before the database is opened for analysis. Consequently, the delivery of the
|Copyright©2010 PR Newswire.
All rights reserved


text:
Live updates
Team news: York City v Hartlepool United
York City starting line-up v Hartlepool: Flinders, Lowe, Winfield, Zubar, McCoy, Summerfield, Penn, Berrett, Tutonda, Oliver, Thompson
Pools unchanged: Bartlett, Duckworth, Harrison, Worley, Carroll, Magnay, Featherstone, Woods, Fenwick, Paynter, Bingham.
York City to face Newcastle United in friendly
York City face Premier League side Newcastle United in a pre-season friendly at Bootham Crescent tonight.
The Minstermen haven't won any of their opening five pre-season fixtures. While the Magpies have won just twice, a 1-0 win away to Gateshead and a 1-0 victory against Sacramento Republic on the club's tour of the USA.
Meanwhile, Middlesbrough face Barnsley at Oakwell in a pre-season friendly this evening.
Both matches are scheduled for a 7:45pm kick-off.
- ITV Report
Capital One Cup: The North East opponents for Round 1
The first round of the Capital One Cup has been announced. Find out which opponents teams in North East have drawn:Read the full story ›
Boro confirm pre-season friendly with York
Middlesbrough have confirmed the club are staging a pre-season friendly match against York City.
Boro will face the Minstermen at Bootham Crescent on July 11 (12pm) in the club's first senior friendly ahead of the 2015/16 Championship season.
It's also confirmed that Middlesbrough will travel to Doncaster Rovers on Saturday July 25 (3pm).
The club is expected to confirm further pre-season games in due course. It's anticipated that there will be a fixture at the Riverside on Saturday August 1.
Clarke Carlisle gets ban for drink-driving
Former York City footballer Clarke Carlisle has been banned for three years and ordered to do 150 hours of unpaid community work after being found guilty of drink-driving.
GOAL: York 0-1 Dag & Red
19' It's a wonderfully composed goal from Cureton who makes the most of Bingham's pass. [0-1]. #COYD
Clarke's wife: 'Don't dare leave me a widow'
The wife of former Burnley skipper Clarke Carlisle has told how she pleaded with her husband not to die following a suicide bid.
In an interview with the The Sun Gemma said: 'Nothing could prepare me for what I saw. There was so much blood. It was everywhere. His face was twice the size. His eyes were bulging out and they were filled with blood.'
It comes a day after Clarke revealed he intentionally leapt out in front of a lorry days before Christmas as he battled depression.
Read more here.
- ITV Report
- National
Little under fire for Twitter attack on Clarke Carlisle
Actor Ralf Little has sparked anger after criticising ex-footballer Clarke Carlisle over an interview about his suicide attempt last year.Read the full story ›
Clarke Carlisle: "I leapt in front of lorry hoping to die"
Former Leeds United player Clarke Carlisle has revealed he tried to take his own life by jumping in front of a lorry in North Yorkshire before Christmas.
The former England star told The Sun he thought he was better off dead after losing his TV pundit job and battling depression for 18 months.
He said the final straw came in December 20 when he was charged with drink driving.
Before he leapt in front of a lorry on the A64, Clarke told the newspaper he thought about trying to drown himself and even laid down on a railway line but moved out of the way before a train came.
Describing what happened next, he said: "I saw the big truck. I stepped over the barrier. I took two steps into the road and then jumped into the truck, like a full shoulder charge. I can remember the impact. Bang. Then lights out.
"I opened my eyes and I could see my hands in front of me and there's blood dripping down them. I thought, 'You're kidding me?'"
Clarke was airlifted to hospital after escaping with just a few cuts and bruises, a broken rib and a shattered knee.
The footballer has since sought treatment for his depression and has spoken out to encourage others to get help.
He added: "My road to recovery will be eternal but today I am excited and confident because I've finally been diagnosed."
If you have been affected by any of the issues in this article, you can call Samaritans 08457 90 90 90 or visit the website
Clarke Carlisle's wife urges sufferers to 'speak out'
Clarke Carlisle's wife has appealed to anyone suffering from depression to 'reach out' - she has also retweeted a series of other people's tweets about the illness. Her husband has spoken out for the first time about his struggle.
Please if anyone is suffering... know that it WILL get better. I can promise you that. Reach out to someone, anyone. You're not alone
Best description of Depression I've read. "a cancer of the soul". If you struggle today is #TimeToTalkDay


text:
Page 1
A Synthetic Nucleoside Probe that Discerns a DNA Adduct from Unmodified DNA
Jiachang Gong and Shana J. Sturla*
Department of Medicinal Chemistry and The Cancer Center, UniVersity of Minnesota, Minneapolis, Minnesota 55455
Received January 30, 2007; E-mail: firstname.lastname@example.com
Biologically reactive chemicals alkylate DNA and induce
structural modifications in the form of covalent adducts.1Certain
bulky DNA adducts can persist, escape repair, and serve as
templates for polymerase-mediated DNA synthesis, resulting in
mutation and cancer.2Correlating chemical structures and quantita-
tive levels of adducts with toxicity is central to understanding
chemical mechanisms of carcinogenesis for specific agents. Major
challenges include that DNA adducts are formed at exceedingly
low levels, adduct mixtures are often formed, and minor lesions
may have greater biological impact than more abundant products.2
New molecular approaches for addressing specific low-abundance
adducts are needed, and we describe here the first example of a
synthetic nucleoside that may serve as the chemical basis for a probe
of a bulky carcinogen-DNA adduct.
Dozens of thermodynamically stable synthetic base pairs have been
reported3and continue to emerge as powerful tools in areas such as
polymerase fidelity,4DNA helix stability,5nucleic acids with novel
functionality,6and expanded genetic systems,3to cite selected exam-
ples. Recently, Hirao and co-workers successfully have amplified
an entirely synthetic base pair.7Amplified in a polymerase-mediated
process or used in hybridization-based strategies, synthetic nucleo-
sides might act as probes of DNA damage, but to our knowledge,
no examples of synthetic nucleosides that pair selectively with an
adduct generated in a natural physiological system are known.
O6-Benzyldeoxyguanosine (1, O6-BnG; Figure 1) is a bulky DNA
adduct chosen for analysis because of its prominent role in nucleic
acid chemistry and biology and the high frequency of O6-
alkylguanine lesions.8,9This adduct results naturally from exposure
to environmental carcinogens8a,band is highly mutagenic, causing
G to C and G to T transversion, and G to A transition mutations.8c,d
O6-Alkylguanine adducts have altered hydrogen-bonding capacity,
increased size, and decreased hydrophilicity relative to G (Figure 1).
On the basis of molecular modeling studies,10we anticipated that
a diaminonaphthyl-derived nucleoside (2, dNap; Figure 1) would
possess a hydrogen-bonding capacity complementary to O6-BnG
and favorable π-π stacking and hydrophobic interactions between
the benzyl moiety of O6-BnG and the naphthyl moiety of dNap 2.
To evaluate the O6-BnG:dNap base pair in duplex DNA, we
prepared a series of oligonucleotides containing selected combina-
tions of DNA adduct, synthetic nucleoside, and/or natural bases.
Nucleoside 2 was synthesized from diaminonaphthalene 3 (Scheme
1). Treatment of 3 with ethyl chloroformate produced perimidinone
4 (70% yield), which was coupled with bistoluoyl chloroglycoside
to yield the ?-isomer of 5 as the major product. Deprotection, 5′-
tritylation, and conversion to the 3′-phosphoramidite 6, required
for oligonucleotide synthesis, were achieved in 50% yield overall.
Duplex DNA stability was determined by thermal denaturation
of synthetic oligonucleotides. Melting temperatures (Tm) were mea-
sured for complementary sequences 5′-TTGTCGGTATAXC GG-
3′ and 5′-CCGYTATACCGACAA-3′ with varying bases incorpo-
rated at positions X and Y. The results indicate that O6-BnG:dNap
is markedly stable (8.0 µM) with a Tmvalue one degree lower than
that of the natural dG:dC pair (Figure 2, D1 Tm) 60.3 vs D6 Tm
) 59.3). Sequence D5 represents a situation in which natural DNA
is damaged, giving rise to the O6-BnG adduct and a diminished
thermal stability. Further, the adduct:probe pair Tmwas compared
to O6-BnG paired with canonical bases. These combinations have
diminished stabilities relative to the synthetic pair by 5.0, 6.6, 4.7,
and 5.9 °C for dG, dA, dC, and dT, respectively (Figure 2). Simi-
larly, for dNap paired opposite the natural bases, Tmdiminished to
55.3, 54.8, 52.5, and 52.5 °C for dG, dA, dC, and dT, respectively.
These data are comparable to optimized synthetic base pairs, in
which approximate ranges of 4-9 °C in Tm depressions are
considered highly stable and orthogonal systems.3eTmvalues for
point mutations in D1, which reflect the selectivity of natural base
pairs, decrease by an estimated average of 9 °C.11
Figure 1. Schematic representation of base-pair interactions for a standard
G:C pair, alkylation-damaged O6-BnG 1:C pair and proposed adduct:probe
combination (dR ) deoxyribose).
Scheme 1a
aReagents and conditions: (a) ethyl chloroformate, THF; (b) bistoluoyl
chloroglycoside, NaH/THF; (c) NaOMe/methanol; (d) 4,4′-dimethoxytrityl
chloride, pyridine; (e) N,N′-diisopropyl-2-O-cyanoethyl phosphoramidic
chloride, Et3N, CH2Cl2.
Figure 2. Thermal stabilities of natural, damaged, and dNap DNA.
Published on Web 04/03/2007
10.1021/ja070688g CCC: $37.00 © 2007 American Chemical Society
Page 2
A goal for potential biological applications is that dNap distin-
guish between isomeric adduct structures resulting from competing
positions of base alkylation. We compared damaged oligonucle-
otides that contained O6-BnG or the isomeric adduct N2-ben-
zyldeoxyguanosine (7, N2-BnG). The N2-BnG:dNap pair was less
stable, but the difference was small (Tmof 57.4 °C, 1.9 °C lower than
that of O6-BnG:dNap). Many known synthetic nucleosides form
stable self-pairs in duplex DNA.3e-gSimilarly, the Tmfor a duplex
containing dNap:dNap is 60.3 °C, essentially as stable as dG:dC.
Thermodynamic relationships for key base pairs were evaluated
further by a van't Hoff analysis (Table 1).12The relative free-energy
changes parallel those observed for Tmvalues, with high Tmvalues
associated with high free-energy changes upon duplex formation.
Entropic contributions were similar for each example.
To verify whether the modified oligonucleotides formed strictly
duplex structures, a titration study (Job plot) was performed by
measuring UV absorbances at 260 nm for various molar ratios of
the single strands. These data (Figure S3-S5, Supporting Informa-
tion) clearly indicate 1:1 stoichiometric binding. To probe the
helicity of the key duplexes in Figure 2, circular dichroism (CD)
spectra of duplexes D1, D2, and D6 were obtained. The resulting
CD spectra (Figure S6, Supporting Information) display positive
signals at 271-274 nm and negative signals at 248-251 nm,
indicating a B-form conformation of DNA duplexes. Similar
patterns of CD spectra suggest that the synthetic base pair does
not significantly perturb duplex conformation.
The relative stereochemistry of free dNap was assigned on the
basis of NOESY correlations (obtained from 5, Supporting Informa-
tion) and confirmed by X-ray analysis of the free nucleoside 2
(Figure 3). Both indicate that the nucleoside favors a syn glycosidic
torsion angle, contrasting the anti-conformation proposed to maxi-
mize H-bonding and π-stacking interactions (Figure 1). The energy
barrier between syn and anti nucleoside conformations (Figure 1)
is typically low,13and there may be structural differences among
the same free nucleoside in solution or solid state, duplex DNA, or
in the presence of other nucleosides.14,15The relationship of the dNap
network in the crystal structure indicates a potential for π-π inter-
actions with an extensive array of face-to-face slipped π-π stacking
and hydrogen-bonding interactions of the naphthalene and deox-
yribose moieties, respectively, with adjacent dNaps arranged in
alternating orientations with about 3.2 Å between neighboring
parallel naphthyl groups. Further studies to determine the nucleoside
structure in the context of duplex DNA in the presence and absence
of adduct are required to understand the origin of the experimentally
observed stabilizing effect.
The novel naphthalene-derived nucleoside forms an orthogonal
and thermodynamically stable base pair with the biologically
significant DNA adduct O6-BnG. This is the first report of a stable
DNA base pair comprised of a biologically relevant bulky DNA
adduct and a designed nucleoside partner. Synthetic nucleosides
that base pair specifically with DNA adducts have diverse potential
utility in the study of the impacts of chemical modification on DNA
biology and chemistry. Continued studies are aimed at gaining a
detailed understanding of the physical and structural origin of
adduct:probe base-pair stability, the design of more selective
analogues, and applications as structural probes.
Acknowledgment. We acknowledge the NIH (CA108604) for
support. J.G. thanks the University of Minnesota Cancer Center
for a postdoctoral fellowship. We thank Dr. Besik Kankia for helpful
suggestions, and Dr. Yuk Sham, University of Minnesota Super-
computing Institute, for assistance with molecular models. Crystal-
lographic analysis was carried out by Dr. Victor G. Young, Jr. at
the X-ray Laboratory of the University of Minnesota.
Supporting Information Available: Syntheses, NMR data, thermal
denaturation studies, crystallographic analysis, Job plots, and CD
spectra. This material is available free of charge via the Internet at
(1) (a) Singer, B.; Runberger, D. Molecular Biology of Mutagens &
Carcinogens; Plenum Press: New York, 1983. (b) Phillips, D. H. The
Formation of DNA Adducts. In The Cancer Handbook; Alison, M. R.,
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Loechler, E. L. Carcinogenesis 1996, 17, 895-902. (c) Hecht, S. S. Nat.
ReV. Cancer 2003, 3, 733-744.
(3) (a) Piccirilli, J. A.; Krauch, T.; Moroney, S. E.; Benner, S. A. Nature
1990, 343, 33-37. (b) Moran, S.; Ren, R. X. F.; Rumney, S.; Kool, E. T.
J. Am. Chem. Soc. 1997, 119, 2056-2057. (c) Kool, E. T. Acc. Chem.
Res. 2002, 35, 936-943. (d) Benner, S. A. Acc. Chem. Res. 2004, 37,
784-797. (e) Wu, Y.; Ogawa, A. K.; Berger, M.; McMinn, D. L.; Schultz,
P. G.; Romesberg, F. E. J. Am. Chem. Soc. 2000, 122, 7621-7632. (f)
Ogawa, A. K.; Wu, Y.; McMinn, D. L.; Liu, J.; Schultz, P. G.; Romesberg,
F. E. J. Am. Chem. Soc. 2005, 122, 3274-3287. (g) Henry, A. A.; Olsen,
A. G.; Matsuda, S.; Yu, C.; Geierstanger, B. H.; Romesberg, F. E. J. Am.
Chem. Soc. 2005, 126, 6923-6931.
(4) (a) Bloom, L. B.; Otto, M. R.; Beechem, J. M.; Goodman, M. F.
Biochemistry 1993, 32, 11247-11258. (b) Matray, T. J.; Kool, E. T.
Nature 1999, 399, 704-708. (c) Sun, L.; Xhang, K.; Zhou, L.; Hohler,
P.; Kool, E. T.; Yuan, G.; Wang, Z.; Taylor, J. S. Biochemistry 2003, 42,
9431-9437. (d) Zhang, X. M.; Lee, I.; Zhou, X.; Berdis, A. J. J. Am.
Chem. Soc. 2006, 128, 143-149. (e) Mizukami, S.; Kim, T. W.; Helquist,
S. A.; Kool, E. T. Biochemistry 2006, 45, 2772-2778.
(5) Gao, J.; Liu, H.; Kool, E. T. J. Am. Chem. Soc. 2004, 126, 11826-11831.
(6) (a) Hirao, I.; Ohtsuki, T.; Mitsui, T.; Yokoyama, S. J. Am. Chem. Soc.
2000, 122, 6118-6119. (b) Mitsui, T.; Kitamura, A.; Kimoto, M.; To,
T.; Sato, A.; Hirao, I.; Yokoyama, S. J. Am. Chem. Soc. 2003, 125, 5298-
5307. (c) Kimoto, M.; Endo, M.; Mitsui, T.; Okuni, T.; Hirao, I.;
Yokoyama, S. Chem. Biol. 2004, 11, 47-55.
(7) Hirao, I.; Kimoto, M.; Mitsui, T.; Fujiwara, T.; Kawai, R.; Sato, A.;
Harada, Y.; Yokoyama, S. Nat. Methods 2006, 3, 729-735.
(8) (a) Moschel, R. C.; Hudgins, W. R.; Dipple, A. J. Org. Chem. 1980, 45,
533-535. (b) Peterson, L. A. Chem. Res. Toxicol. 1997, 10, 19-26. (c)
Mitra, G.; Pauly, G. T.; Kumar, R.; Pei, G. K.; Hughes, S. H.; Moschel,
R. C.; Barbacid, M. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 8650-8654.
(d) Pauly, G. T.; Moschel, R. C. Chem. Res. Toxicol. 2001, 14, 894-
900. (e) Dolan, M. E.; Pegg, A. E. Clin. Cancer Res. 1997, 3, 837-847.
(9) (a) Mishina, Y.; Duguid, E. M.; He, C. Chem. ReV. 2006, 106, 215-236.
(b) Margison, G. P.; Santibanez, K.; Mauro, F.; Povey, A. C. Mutagenesis
2002, 17, 483-487.
(10) Using the program Insight II and information from adduct structures within
a ternary complex with a DNA polymerase, such as: Ling, H.; Sayer, J.
M.; Plosky, B. S.; Yagi, H.; Buodsocq, R.; Woodgate, R.; Jerina, D. M.;
Yang, W. Proc. Natl. Acad. Sci. U.S.A. 2004, 8, 2265-2269.
(11) Calculated for all point mutations at X,Y in Figure 2 sequence using the
DINAMelt server, http://www.bioinfo.rpi.edu.
(12) Marky, L. A.; Breslauer, K. J. Biopolymers 1987, 26, 1601-1620.
(13) Rosemeyer, H.; To ´th, G.; Golankiewicz, B.; Kazimierczuk, Z.; Bourgeois,
W.; Kretschmer, U.; Muth, H.; Seela, F. J. Org. Chem. 1990, 55, 5784-
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Table 1. Thermodynamic Parameters for Duplex Formation
∆H (kcal/mol)
∆S (cal/K'mol)
Figure 3. Stacking interactions in 2 indicated in X-ray crystal structure
(unit cell dimensions: a ) 6.5 Å; b ) 8.7 Å; c ) 23.5 Å).


text:
Teenage Mutant Ninja Turtles III
Directed by Stuart Gillard. Starring Mark Caso, Jim Raposa, Matt Hill, David Fraser, Paige Turco, Elias Turco, Vivian Wu, Sab Shimono, Stuart Wilson. (1993)
REVIEWED By Marjorie Baumgarten, Fri., March 26, 1993
The kids sure do love these creatures. Their folks can't understand why. And that, in a nut -- er, tortoise -- shell justifies the attraction. They are legend; they are lore; they are turtles; hear them roar. We won't dwell here on their history or their past, it wouldn't contribute especially to our understanding. All you need to know is that this time our teenage mutants time-travel back to 17th century Japan. Why? Because it's there? Because they're ninjas? Because it's the only way to rescue their friend April (Turco) who's gotten sucked into the time-space continuum by some discarded scepter she found at a flea market? Plot's not a real big concern in this epic. Neither is plausibility (things like, why is everyone in feudal Japan bilingually adept at both English and Japanese?). While four 17th century Japanese bodyguards get beamed up to modern-day New York City to fill the spatial void created by the turtle teens' absence, our hard-shelled heroes scrappily wend their way through Japanese palace and countryside doing what their audiences best love them for -- smart-mouthing and ninja fighting. These fun-loving mutants meet life on their own terms, they are heroes despite themselves. Their appeal is apparently strong enough to overcome any potential disturbance regarding plot disjointedness, pseudo-scientific reasoning and historical inaccuracy. Still, these Teenage Mutant Ninja epics are not really mind-numbing so much as mind-less. And it's unlikely that any new chapter in the series will ever rival the first installment for its sheer originality of concept. I mean, we're talking teenage-mutant-ninja-turtles. Where do you go from there? To the dictionary for more adjectives? Look at it this way; it could be worse. Your kids could be hooked on Barney.


text:
Edit hours
Acme Lowcountry Kitchen now combines upscale, yet casual elements of traditional Lowcountry cuisine with classic fare. Breakfast, lunch, and dinner are served in a casual beach atmosphere with flavor profiles that exemplify fresh local ingredients and seafood.
The fried scallops, mashed potatoes and butter beans were delicious!! Absolutely worth going to again and again!!
Seafood and mojitos
First time a charm
The fried mahi fish tacos are the best tacos in Charleston, which is why they're on our list of The Tastes That Make the City: Charleston. Read more
Try the Blackened Shrimp Over Grits With Sausage - (via @Foodspotting)
Lobster grits-fabulous!
Thursday night lobster tail specials were cooked perfectly. Pork rind nachos are worth.
Hard to go wrong with the specials. They do pride themselves on the grit :-) Frank has never made us a bad meal. The squid has been the best we have had to date. Do enjoy
Bar is the place to be
Unbelievable breakfast. Not a bad choice on the menu.
Great tartar sauce with the flounder basket. Nice patio.
Fried Mahi Fish Tacos, Collards and Cheese Grits. Highly recommend!
My girlfriend and I have been here at least five or six times and this has become one of our favorite restaurants. The Fried Pickles and Jalepeños, Lowcountry Shrimp and Grits are excellent!
Fried Mahi Fish Tacos, Lowcountry Shrimp and Grits, Gouda Grit Fries, Fried Pickles and Jalepeños, Oysters Rockafeller, Fried Green Tomatoes
Absolutely delicious! Amazing lobster Gouda Mac and the best shrimp and grits! Can't wait to go back!
Amazing! Try shrimp and grits or mimosa pitchers :) love this place!
Have been several times and enjoyed. Just had a very poor experience though. Portions were small and over cooked. We were very disappointed this time. Hopefully will be better in the future.
Best grits I've ever had. Only grit I've ever liked!
3 Grilled Lobster Tails + 2 sides for $20 on Thursday Nights!
Awesome Sunday brunch and grits.
Favorite restaurant on the island. Quality food, excellent service. Love their breakfasts.
New Years' Eve Menu Announced Read more
This place has stellar food, the seafood is local and wonderful and the steaks are perfectly cooked. We come here every time we're on IOP.
I come here ALL the time when intown, best $5.00 you-call-it Happy Hour & Order the chicken tacos, Holy Sh*t, I just finally did. Why was I not doing this before? The Flavor balance is perfect.
Always delicious. The reviews are right, the grits are awesome!
I just ate eggs with crab, shrimp and scallops. I can die a happy lady.
Call ahead -- they take reservations.
Worth every penny food was so fresh it was unbelievable will return next time in town
Bloody's with house mix is the best!
Service is spectacular! Try the grilled cesar salad w/fried green tomatoes. Unique & tasty!
The service was pretty bad and the food was even worse. The fish tacos looked amazing, but these were the worst I've ever had. TASTELESS!
Shrimp and grits are delicious here'
Great place to eat for wings and almost everything is Great!!
OMG. If you live buffalo wings you MUST try the Blu-ffalo! Dipped in buffalo sauce and then ROLLED in Bleu!
Zombies like hot meat. Watch out if we're in the house. You're DINNER!
Love the wings. Best place to eat is in the bar.
If you go hotter than Med on the wings make sure you got extra blue cheese on hand to counter the HOT.
Wicked good best $7.25 chicken biscuit and grits and for later they have Ranger IPA ON draft too
Salmon & grits. Yes
A great, local beach place. Their pancakes are awesome! -Box
Acme Lowcountry Cantina Updates Menus By Adapting Concept to Upscale Casual
Slow service. Hostess doesn't know what she's doing at all.
Fish Tacos
New lunch and dinner menus Read more
This place is wonderful. The servers are nice, and the food is to die for.
Service can be slow, but the food is great. The crab cake eggs Benedict is a game changer.
Delicious pimento cheese grits and fried oysters!
Bloody Mary's rock!
The best grits ever!! Creamy goodness. They can't seem to make hot coffee- luke warm...
Yummy Mahi Burritos!


text:
Tattoos? Really??.. ughh ( vent )
Wow your son is so cute they made him into a computer wallpaper!! You are so lucky!
~Lydia mommy to Ben 3/25/10 9 lb 5 oz, Angel Baby 10/31/11 (10 wks), Rainbow Baby Ellie 9/9/12 10 lbs 12 oz <3 My Chart <3
this is my tattoo on my shoulder i got for my 3 angels in heaven...trashy enough?
Charlotte Annelynn - 9/21/12
Suprise! - EDD 9/22/13
Married to my soulmate 4.5.12
DS 9.29.12 DD 3.2.14 born at home platinum ( • Y • )
Baby #3 EDD 4.22.16 ~ planning for a homebirth
You really shouldn't judge people by their tattoos and call them trashy, you'd be surprised at who has them these days. And who knows, maybe it's not bad art. Maybe her tattoo is done exactly how she wanted and it has a message or meaning behind it that you just don't understand. I bet if you called her trashy that she would call you ignorant.
*Gena, happily married to Brent since 07/07/07*
*Kimber Lily 01/30/11, 7lbs 7.5oz and 19.5"
*Marshal Reed 09/15/12, 8lbs 4oz and 19.5"*
ღஐƸ̵̡Ӝ̵̨̄Ʒஐღ I danced myself out of the womb. Is it strange to dance so soon? ღஐƸ̵̡Ӝ̵̨̄Ʒஐღ
ღஐƸ̵̡Ӝ̵̨̄Ʒஐღ I danced myself out of the womb. Is it strange to dance so soon? ღஐƸ̵̡Ӝ̵̨̄Ʒஐღ
mommamia thank you! :) its my favorite of mine
Charlotte Annelynn - 9/21/12
Suprise! - EDD 9/22/13
My husband on his tour in Iraq after he lost his battle buddy. He's 6th over in the back.
Being well...yeah haha. Tattoes and all!
Right before we got married in May of this year.
Married 06/19/2012 to Greg.
Lily Kate 05/14/13.


text:
- The Great British Baking Show II: Biscuits & Tray Bakes
Sunday, October 4 at 7:00 p.m.
The remaining eight bakers are faced with biscuits and traybakes.Read more
- Home Fires on Masterpiece, Part 1
Sunday, October 4 at 8:00 p.m.
Samantha Bond ("Downton Abbey") and Francesca Annis ("Reckless") star in a moving drama about women in an English village facing the onset of World War II.Read more
- Indian Summers on Masterpiece, Part 2
Sunday, October 4 at 9:00 p.m.
While Aafrin fights for his life, Ralph confronts the gunman in jail. Sarah is suspicious of Alice's past. Adam goes missing.Read more
- The Widower, Part 1
Sunday, October 4 at 10:00 p.m.
This is the true story of Malcolm Webster, a nurse by profession and, on the surface, a perfect gentleman: well-spoken, personable and charming. He's also a spendthrift and killer.Read more
- Antiques Roadshow: Seattle, Part 1
Monday, October 5 at 8:00 p.m.
The "Roadshow" rocks out at Seattle's EMP Museum and discusses Jimi Hendrix' trend-setting fashion style.Read more
- Antiques Roadshow: Albuquerque, Part 2
Monday, October 5 at 9:00 p.m.
Another new episode from Albuquerque premieres tonight.Read more
- I'll Have What Phil's Having: Italy
Monday, October 5 at 10:00 p.m.
Join Phil as he revisits this food mecca. Sit down with him as he feasts on a home-cooked meal at chef Nancy Silverton's Umbrian home and indulges his inner caveman, roasting gargantuan steaks over hot flames and serving them up "barbarian style."Read more
- Gorongosa Park: Rebirth of Paradise, Parts 5 & 6
Tuesday, October 6 at 8:00 and 9:00 p.m.
In the final episodes, Joyce Poole makes a breakthrough with the elephants in Gorongosa, while her brother Bob spends a night chasing a group of crop-raiding elephants.Read more
- Frontline: My Brother's Bomber, Part 2
Tuesday, October 6 at 10:00 p.m.
One man's search for the terrorists who blew up Pan Am Flight 103 over Lockerbie continues this week on "Frontline."Read more
- Nature: Big Birds Can't Fly
Wednesday, October 7 at 8:00 p.m.
David Attenborough explores the evolution the oddballs of the avian world that have adapted to living on the ground.Read more
- Nova: Secrets of Noah's Art
Wednesday, October 7 at 9:00 p.m.
A team historians and boat-builders attempts to build the flood boat using inscriptions from an ancient clay tabletRead more
- Nova: Petra -- Lost City of Stone
Wednesday, October 7 at 10:00 p.m.
More than 2,000 years ago, the thriving city of Petra rose up in the bone-dry desert of what is now Jordan.Read more
- Views: 397 Toledo Stories: War of 1812 in the Old Northwest
Thursday, October 8 at 8:00 p.m.
In 1812, a very young United States of America had its sights set on expansion to the north and the west.Read more
- Miss Fisher's Murder Mysteries: Murder on the Ballarat Train
Thursday, October 8 at 9:00 p.m.
Phyrne travels to the country by train to collect her new Hispano-Suiza motor car.Read more
- Unity: The Latin Tribute to Michael Jackson
Friday, October 9 at 9:00 p.m.
World-class drummer and percussionist Sheila E. hosts a concert special that showcases Latin artists performing Latin-infused arrangements of Michael Jackson songsRead more
- 2015 Hispanic Heritage Awards
Friday, October 9, 2015 at 10:00 p.m.
The Hispanic Heritage Awards were established by The White House in 1987 to commemorate the creation of Hispanic Heritage Month in America.
The Hispanic Heritage Awards are considered among the "highest honor for Latinos by Latinos" and recognize notable Latinos who have made a positive impact on America, and the world, in various fields. Legendary actress Rita Moreno (pictured) will host year's gala awards ceremony.
- Call the Midwife III, Part 2
Saturday, October 10 at 8:00 p.m.
Trixie is upset when Sister Julienne promotes Jenny to "acting sister."Read more
- The Great British Baking Show II: Sweet Dough
Sunday, October 11 at 7:00 p.m.
It's week six and time for sweet dough — but will it prove bittersweet for the bakers?Read more
- Home Fires on Masterpiece, Part 2
Sunday, October 11 at 8:00 p.m.
The Women's Institute is back, and the RAF arrives in town.Read more
Meanwhile, Pat endures abuse. Alison's dog has a close call. The local doctor faces up to his fate.
- Indian Summers on Masterpiece, Part 3
Sunday, October 11 at 9:00 p.m.
Sooni gets into trouble. Witness-tampering runs riot. Ramu confronts Armitage at the annual fair. Dougie confesses to Sarah.Read more
- The Widower, Part 2
Sunday, October 11 at 10:00 p.m.
After two failed attempts on Felicity's life, Malcolm returns to Scotland and reinvents himself — this time as the perfect boyfriend to Simone. However, DS Henry is hot on his heels and will stop at nothing to prevent the next murder.Read more


text:
At the 82nd Geneva Motor Show Hyundai showcased their latest i20 in a new avatar. The facelifted i20 will undoubtedly make its way to India very soon and so it was of keen interest to us when we saw it in Geneva. Keeping design hues in line with Hyundai's fluidic design concept, the new i20 will be curvier and sexier. The headlights have become thinner and the front grille is hexagonal, while the front bumper is completely new. The rear has also been changed with restyled tail lights and a new bumper. The most important change comes in the form of the engine as the i20 will now comes with a brand new 1.1 litre 3-cylinder diesel engine that can produce a very healthy 75bhp. It will also emit much less CO2, but whether this engine makes it to India is uncertain. But we do know for sure that by the end of this year the new i20 will definitely be in India.
Hyundai i20 facelift coming to India
3 Responses to Hyundai i20 facelift coming to India
Kedar Borgaonkar, on March 25, 2012 at 12:05 am Said:
Dear Sir/Madam,
I am planning to buy i20 (petrol or diesel not sure) but waiting for new look i20.
Can you pl. let me know when this new facelifted i20 will be launched in india and whether diesel version of 1.1 litre will be launched in India or not ?
Kedar Borgaonkar
Cars in India, on March 29, 2012 at 6:27 pm Said:
Hyundai i10 got a huge success in India that's definitely attracts the automotive industry in India to look at this new version from Hyundai. i20 got good numbers of features. Design of the car is awesome, it got luxuries interiors and 1.1 litre 3-cylinder diesel engine is more than enough to drive this car on city roads.
Hyundai i20, on April 13, 2012 at 4:19 pm Said:
Its good, this blog is really got something up to date info
Thaknx for sharing
Leave a Reply
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text:
Coal Advocates Fear Obama's Policies Endanger Industry
The Financial Post reported that the coal industry feels that it is in danger of near-elimination under Obama's rule.
As quoted in the market report:
There are no coal-fired plants being built. Mr. Obama took care of that. I think we're totally eliminated by 2035," said Murray, 73, a prominent advocate for his industry and a fund-raiser for Republican Party causes.
Get the top stories on resource investing FREE!Learn what is going on before you buy from this FREE Special Report, Who is Kitco? to US Mint: Sold Out! – Top Articles from Resource Investing News.


text:
Tear Jerker: Karin
- The end of the Karin The Chibi Vampire manga. Not only does Karin's older brother Ren wipe all her memories of her family but he does it with his last and only sign of brotherly affection. A pat on the head, because 'you don't like it when I'm rough, do you?' And we learn that all those times he gave her noogies were to help the memory wiping process and Dear God, her family was planning this from the start because she wasn't a normal vampire and they wanted her to have a normal life in the end. Which they could never give her. And then, on top of that, we get the most bittersweet moment in the manga when Usui Kenta asks Karin if she remembers her family and she replies 'I don't have a family' while crying without knowing why, making Kenta cry as well- and then, he finally proposes making it so so wonderful and painful at the same time.
- Anju awakening as a vampire, leaving her life with Karin behind. The poor girl breaks down into tears after hearing an Innocently Insensitive "congratulations" from Karin, and she cries for the rest of the night.


text:
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