text:
Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells
ABSTRACT IL-23, an IL-12 family member, has been implicated in the development of Th17 cells and the progression of autoimmune diseases. However, due to the lack of availability of sensitive Ab reagents specific for the IL-23 receptor (IL-23R), it has been difficult to characterize the cell types that express the IL-23R and are responsive to IL-23 in vivo. To address the role of IL-23 in vivo, we have generated a novel "knock-in" mouse in which we have replaced the intracellular domain of the IL-23R with the GFP. We show that in addition to Th17 cells, a subset of myeloid cells express IL-23R and respond to IL-23 by producing IL-17 and IL-22. Our studies further demonstrate that IL-23R expression is crucial for generation of encephalitogenic Th17 cells, but its expression on the innate immune system is dispensible in the development of experimental autoimmune encephalomyelitis.
Full-textDOI: · Available from: Caroline Pot, Jan 22, 2014
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Article: Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells
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- SourceAvailable from: Fereshteh Alsahebfosoul
- "The IL-23p19 or IL-23R knockout mice were resistant to EAE. IL-23R is also expressed in the central nervous system by infiltrated macrophages, and macrophages expressing IL-23R in response to IL-17, IL-22, and IL-23 release (Awasthi et al., 2009; Cua et al., 2003; McGeachy et al., 2009). Therapeutic treatment with Anti-IL-23p19 can reduced the IL-17 serum level as well as mRNA expression of IL-6, IL-17, TNF, IFN-c, and Interferon gamma-induced protein-10 (IP-10) in central nervous system. "
Article: IL-23 Plasma level measurement in relapsing remitting multiple sclerosis (RRMS) patients compared to healthy subjects[Show abstract] [Hide abstract]
ABSTRACT: Background: Multiple sclerosis (MS) is a chronic neuroinflammatory disease with unknown etiology and variable clinical evolution. Interleukin-23 (IL-23), a member of the IL-12 cytokine family is a heterodimeric cytokine composed of the IL-12p40 subunit, and with a novel p19 subunit, its ability to enhance the expansion of T helper type 17 (Th17) cells indicates the responsibility for many of the inflammatory autoimmune responses. Objective: The objective of the project is to measure IL-23 level in plasma of multiple sclerosis (MS) patients in comparison with healthy control subjects. Methods: In a case-control study, plasma was collected from healthy subjects as control group (n = 40) and patients with relapsing remitting multiple sclerosis (RRMS) (n = 40). The plasma level of IL-23 was assessed by ELISA method. Statistical analysis was performed with SPSS (Ver. 16). Results: Plasma level of IL-23 in MS patients was significantly increased compared to control subjects (p Value < 0.001). Conclusions: Our findings revealed the increased IL-23 level in patients' group. In conclusion, the inhibition of IL-23 might be a novel and promising therapeutic strategy, especially in the therapy of autoimmune inflammatory diseases. IL-23 plays a pivotal role in development of MS and might be a specific marker and therapeutic target for MS.Immunological investigations 08/2014; 44(1):1-9. DOI:10.3109/08820139.2014.930477 · 1.99 Impact Factor
- "Among the CD4 T-cells, interleukin 17 (IL-17) producing T helper 17 (Th17) cell has a pivotal role in harmony with the natural and acquired immune responses to the extracellular bacteria and fungi[6] and also in the pathogenesis of several autoimmune and inflammatory disorders.[7] The retinoic acid receptor-related orphan receptor C2 (RORC2) transcription factor and IL-23R are expressed by the Th17 cells.[789] Development of Th17 cells and expression of their specific cytokines IL-17A and IL-17F are promoted by the RORC2.[10] "
Article: Evaluation of the T helper 17 cell specific genes and the innate lymphoid cells counts in the peripheral blood of patients with the common variable immunodeficiency[Show abstract] [Hide abstract]
ABSTRACT: Background: Common variable immunodeficiency (CVID) is characterized by a deficiency in the immune system with a heterogeneous collection of disorders resulting in antibody deficiency and recurrent infections. T helper 17 (Th17) cells promote B-cell survival and synergize with the B-cell activating factor to induce their differentiation into the plasma cells. A sub-population of innate lymphoid cells (ILCs) also produces interleukin 17 (IL-17). This study aimed to measure the Th17 specific genes and ILCs counts in the CVID patients in comparison with control subjects. Materials and Methods: Total messenger ribonucleic acid (mRNA) was extracted from the whole blood samples of 10 CVID patients and 10 healthy individuals. IL-17, retinoic acid receptor-related orphan receptor C2 (RORC2), IL-23R, and IL-9 gene expression were measured using the quantitative reverse transcriptase polymerase chain reaction. Count of lineage negative/CD127+/CD90+ ILCs in the blood samples was performed by the flow cytometry method. Results: The transcript levels of IL-17 and RORC2 in CVID patients was strongly lower than control subjects (P = 0.049 and P = 0.046, respectively), but slight reduction in the IL-23R expression (P = 0.252) have seen in the CVID patients. Accordingly, the number of ILCs decreased significantly (P = 0.04). Interestingly, IL-9 mRNA level was more significantly in the CVID patients (P = 0.001). Conclusions: The results presented in this study show that the Th17 cell specific genes expression (as the determiner Th17 cells) and ILCs (another lymphoid source of IL-17) are decreased in patients with CVID and this could be an explanation for the defect of their humoral immune response. In addition, elevation of the IL-9 gene expression may shed a new light into the way toward the understanding of the mechanism of autoimmunity in the CVID patients.Journal of research in medical sciences 03/2014; 19(Suppl 1). · 0.65 Impact Factor
- "C57BL/6J mice (#664), IL-12Rβ2−/− (#3248), RORγt−/− (#7572) and Rag1−/− (#2216) on C57BL/6 background were purchased from the Jackson Laboratory. IL-12Rβ2−/−, IL-23R-eGFP+/− and IL-23R-eGFP homozygous mice [16] (referred to in the text as IL-23R−/−) were maintained on a C57BL/6 background. IL-23R−/− and IL-12Rβ2−/− were bred to Rag1−/− to respectively generate IL-23R−/−.Rag1−/− and IL-12Rβ2−/−.Rag1−/− mice. "
Article: The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation[Show abstract] [Hide abstract]
ABSTRACT: IL-12 and IL-23 cytokines respectively drive Th1 and Th17 type responses. Yet, little is known regarding the biology of these receptors. As the IL-12 and IL-23 receptors share a common subunit, it has been assumed that these receptors are co-expressed. Surprisingly, we find that the expression of each of these receptors is restricted to specific cell types, in both mouse and human. Indeed, although IL-12Rβ2 is expressed by NK cells and a subset of γδ T cells, the expression of IL-23R is restricted to specific T cell subsets, a small number of B cells and innate lymphoid cells. By exploiting an IL-12- and IL-23-dependent mouse model of innate inflammation, we demonstrate an intricate interplay between IL-12Rβ2 NK cells and IL-23R innate lymphoid cells with respectively dominant roles in the regulation of systemic versus local inflammatory responses. Together, these findings support an unforeseen lineage-specific dichotomy in the in vivo role of both the IL-12 and IL-23 pathways in pathological inflammatory states, which may allow more accurate dissection of the roles of these receptors in chronic inflammatory diseases in humans.PLoS ONE 02/2014; 9(2):e89092. DOI:10.1371/journal.pone.0089092 · 3.23 Impact Factor


text:
Exactly 70 years ago the world changed forever. The Enola Gay dropped the first nuclear weapon used in war on the citizens of Hiroshima. From that moment on the face of the world and the future of humanity became unrecognizable.
Read Whole Story
The world-famous environmentalist and animal rights crusader - who's spent more than half her life working with chimpanzees - has a surprisingly sharp wit and a fiercely sensitive side.
Each year in Atlanta, the cable-mogul-turned-rancher and his daughter Laura Turner Seydel gather a crew of celebs who are as crazy about saving the environment as they are -- all in the name of Captain Planet.
Way too many mothers in places around the world do not have the opportunity to cook a healthy meal for their children in a safe environment. We can provide the seeds of change and help moms and their children to have a better quality of life.
Did you know that just $100 can fund a water-quality test in a stream or river and $500 can provide an inner-city school with plants and tools for an organic vegetable garden? Even smaller amounts can be very meaningful to local recycling or cleanup projects in your community.
The health of citizens and our air, water, and land shouldn't be issues divided along party lines. Protecting our health and the fragile world we live in should be a moral obligation shared by all parties.
Ovie Mughelli, at 30 years old and 245 pounds, is the NFL's greenest star, aiming his eco-efforts at underprivileged kids.
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Healthcare Providers and Services
Company Overview of Sutter Health Network
Executive Profile
Joan Smith-Maclean M.D.
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Dr. Joan Smith-Maclean, M.D. served as Chief Resident at U.C. Davis. Dr. Smith-Maclean served as Chief of Staff at Sutter Davis Hospital has been a member of the Medical Executive Committee since 1992. She serves as a Director at Sutter Health. She served as a Trustee of Sutter Health Sacramento Sierra Region from 2000 to 2011. She helped establish Davis-based Sutter West Medical Group and served on its board of directors for many years. She helped to found the Sutter ...
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text: Daily Quiz for November 21, 2012 HistoryNet Staff 11/21/2012 This American founding father predicted the use of paratroopers some 150 years before they were deployed. Thomas Jefferson George Washington Benjamin Franklin Sam Adams Benjamin Franklin wrote in 1784, "Where is the prince who can afford so to cover his country with troops for its defense, so that ten thousand men descending from the clouds might not, in many places, do an infinite deal of mischief before a force could be brought together to repel them?"? Leave a Reply Cancel Reply Your email address will not be published. Name* Email* Website Comment


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I fear that, eventually, a vicious and bloody revolution will bring about an Iranian-style theocracy in Egypt. It is all too often forgotten that the CIA coup of the democratically elected Mosaddegh government in Iran led to the Iranian revolution twenty years later.
In Pakistan, two politicians who opposed blasphemy laws were assassinated, and a woman was allegedly hacked into 10 pieces by her pious husband becaus...
Those who want to understand the reasons for the coup in Egypt and for the shocking massacres and human rights violations that followed should study the military, not simply as an important institution in Egypt, but as the controlling institution in Egypt.
Over the last weeks, since the inception of the demonstrations in Egypt for president Morsi's ouster, to the sarin gassing of innocents in Syria these past days, the price of oil has skyrocketed. After Saudi Arabia, the most immediate beneficiary of this spiking of oil prices is Russia.
The sight of humans getting sniped and shot in the head, a man crying over his wife's corpse, tens of corpses pushed by a bulldozer with the rest of t...
Amid entrenched political battle lines that have been reinforced by a brutal security force crackdown on supporters of ousted President Mohammed Morsi, Egyptians would do well to look at past events in the Philippines as well as the last two and a half years of their own history.
Anyone following the Egyptian media since President Morsi's overthrow would get a very quick education in how to invent the twilight zone, and then live in it.
Wael Nawara was there when the protests first started in Cairo in January of 2011. Nawara talks about how the landscape of the demonstrations extends beyond those seen in Tahrir Square or in Giza to the outskirts of the cities, to even the most rural of villages.
With Egypt the focus of continuing news attention this past month, it's worth reflecting on the hard work that accompanies political reform.
The EU should reject to be on the same moral level with these regional police states in its approach to the democratic aspirations of the Egyptian people. Such a move would not be only the right thing to do morally, it would also better serve the EU's intermediate and long term strategic interests.
The time to get on right side of the fence has not passed yet and the Obama administration could save future embarrassment by choosing the right path.
Rabaa Adawiya Mosque has become a symbol for Muslim Brotherhood protests in Egypt. The irony is that Rabia Adawiya, the woman -- yes, the woman -- who the mosque was named after, was known for being one of the first people in Islam to have introduce the idea of "divine love."
Given the perceived heavy handedness of the military regime's crackdown and the potential international isolation that Cairo may face in its wake, jihadists within and outside of Egypt may see a ripe opportunity to renew the battle against their most despised "near enemy."
I wrote my string quartet, The Named Angels, against the current backdrop of unrest in the Middle East. Each of the four movements of the quartet portrays of one of the four angels shared by the Jewish, Christian and Islamic faiths.
Responses to the developments in Egypt from American politicians, pundits and the media have too often reflected a lack of sophisticated understanding of what is happening there and a naivete about the appropriate United States reaction.
Many have suggested that the annual $1.3 billion that the Egyptian military is scheduled to receive from Washington also be suspended. Maybe it's time to turn the page and use that money for jobs for Egyptians instead of weapons for their military.


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Family Day / Open House
Happy Howl-o-ween!
Saturday, Oct. 24, 2015
10:00 am — 4:00 pm Admission $6.00
Costumes welcome! Free face painting!
Special Guests at Noon:
Jim Nesci's Cold-Blooded Creatures
Food, Drinks, Gift Shop, Music, and Fun!
Wolves, Cougar, Bear, Coyotes, Woodchuck,
Raccoons, Skunk, Porcupines, and More!
Yearly Season Passes and Adoptions Available
Parking will be at Wal-Mart 16241 Farrell Rd (SW corner of lot) with free non-stop school bus service to the ranch
Handicapped Parking available at the ranch.
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Big Run Wolf Ranch is a 501(c)(3) non-profit, federally licensed, wildlife education facility featuring rescued North American wildlife. Come see "Kuma" the bear, our ten wolves, cougar "Charlie", coyote "Mahala", groundhog "Wilson", raccoons, horses, and many other wild and domestic animals. Come enjoy up close and personal wildlife lectures going on continuously throughout the day along with guided and unguided tours of our facility.
Yearly Season Passes and Animal Adoptions available.
Family Day Menu: Hot Dogs $2.00, Hamburgers $2.50, Cheeseburgers $3.00, Gurge Burger $2.50, Bratwurst $3.00, Chips $0.50, Water $1.00, Pop $1.00, Hot Chocolate (Seasonal)$1.00
Eat like a wolf pup...try our new Gurge Burger (aka Sloppy Joe) :)
Tentative Schedule of Events:
10:45 Wolf Presentation
11:30 Kuma the Bear
12:00 Cold-Blooded Creatures
1:00 Wolf Pup!
1:30 Tiger/Cougar Presentation
2:30 Wolf Presentation
3:15 Wolf Pup!
Smaller animals (groundhog, skunk) will be out throughout the day.


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Economic importance of cockroach???
they are scavengers............
Posted by
Vishu (student) on 31/1/13
do u know anything other than that???
Posted by
Suraj Raj (student) on 31/1/13
Also friend they live in drains and holes in houses and also other animals like rats and lizards are also present in the houses which feed on these cockroaches thereby playing an important role in food chain........
And please dont laugh the cockroaches also fill the pockets of doctors with money..........!!! . Because as you know as these cockroaches spread diseases therefore people have to move to a doctor.....
HAVE A NIC DAY AHEAD :d
Ruins food stuff. Most cockroaches live outside and help to decay organic matter. Believed to spread disease, but contrary to popular opinion, they rarely if ever spread human diseases
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Just Someone (student) on 31/1/13
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Welcome NOVA Neighbors..
Featured Meetup
Fireside chat in my back yard - Music by the three amigos.
Joe, John and Toby have agreed to play acoustic guitars for our enjoyment, The yard has plenty of room if anyone dares to pitch an tent again! This is round three for our outside event in Oakton and this time we our using one of our members for the food, Rich will be catering for $15.00 pr person…this is realy the best way because last time... Learn more
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TOPIC for October 11th: Is Global warming real? (Thanks to Chris H) ... and let's talk about ecology in general. Possible Future Topics : Can America return to the... Learn more
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September 27 · 3:00 PMSunday Philosophy Discussion GroupTOPIC for September 27th: Should politicians be paid? (Thanks to Jeff) Possible Future Topics : Can America return to the principles of the past? (Thanks to Jeff) Is... Learn more
September 23 · 6:30 PMOutdoor happy Hour at Blackfinn - MerrifieldVenue change: Blackfinn in Merrifield has promised to reserve their outdoor patio for our group, and they'll provide extended happy hour specials. AND they might kick... Learn more
September 13 · 3:00 PMSunday Philosophy Discussion GroupTOPIC for September 13th: When is revolution in the streets justified and/or necessary? (I don't know who suggested this topic but feel free to let me know if it was... Learn more
September 13 · 12:30 PMFootball Kick Off PartyLet's have a Sunday Funday with the NFL Kick off. Bennigan's has stated that there will be Happy Hour Specials of some variety during the NFL Games.
September 12 · 2:00 PMAll you can eat shrimp/burger/hot dog feast. $20.00I'm a member of the Moose Lodge located in Fairfax and the 12th at 2:00 is our annual shrimp all you can eat feast, come join me for food and cold beers! Menu - yes... Learn more
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real estate home > real estate directory > NSW > Wollongong/Illawarra > Bellambi > Units for Sale
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Hypnotize others with your style when you don this otherworldly necklace! The shining green eyes and black nose of this accessory's golden, tuxedo collar-sporting bunny pendant will entrance all onlookers. So, wear it with dark wash denim, a plaid shirt, and a leather booties for style so smashing, it'll seem nascent of tangent universe!
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- August 23: General Motors Recalls Chevrolet Impala Over Airbag Problems
- August 14: GM Recalls 73,000 Chevrolet Cobalt Cars Over Airbag Failures
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Last update: Friday 28 August 2015 [25 news items]
AUO and 3M announce new partnership
Aug 28, 11:43
AU Optronics (AUO) and 3M have announced a new technology alliance that combines AUO ALCD (advanced LCD) technology, 3M's quantum dot (QD) enhancement film made with quantum dots...
3M partners with Cambrios to produce flexible silver nanowire film for touch screens
Dec 18, 11:37
3M has launched a touch sensor film, the 3M Patterned Silver Nanowire, which consists of conductors made of Cambrios' silver nanowire ink micropatterned by 3M on a polyester (PET)...
SunPartner and 3M collaborate to deliver wireless transparent solar charging system for consumer mobile electronics
Oct 22, 16:17
Sunpartner Technologies and 3M have announced an agreement to collaborate in product development and technical solutions. The two companies are developing a sustainable wireless transparent...
3M introduces LED advanced light for enclosed commercial applications
Sep 26, 14:22
3M has introduced one of the first LED A19 lamps approved for enclosed fixtures in commercial applications.
3M releases 46-inch high-performance multi-touch display
Jun 6, 19:36
3M Touch Systems has announced the release of its newest high-performance multi-touch display designed specifically for multi-user collaborative applications, the 46-inch 3M multi-touch...
3M announces new development of quantum dot enhancement film
May 21, 20:41
3M has announced it is in the final stages of scale-up for its new 3M quantum dot enhancement film (QDEF). 3M has teamed with Nanosys to produce the 3M QDEF solution specifically...
3M unveils R&D center in Taiwan
Jan 23, 10:59
US-based 3M has unveiled a R&D center in northern Taiwan. The firm said it invested US$1.5 million to set up the center, a 4-story building with a floor space of 933 square meters...
Quanta announces 2Q12 results; details future planning
Aug 31, 01:20
Quanta Computer has announced its financial report for the second quarter with net profit after tax of NT$5.99 billion (US$200.06 million) and EPS at NT$3.80, helping the company's...
3M announces commercial availability of FTB3 barrier film
May 23, 10:19
3M's Optical Systems Division has announced that its 3MFTB3-50 and FTB3-125 films-flexible, optically clear films that protect sensitive electronics from water vapor and oxygen, are...
Sep 14, 11:38
US-based 3M, through its 3M New Ventures organization, has announced it has invested in Pixel Qi, a developer of next-generation LCD panels with operations in Taiwan and California...
Quanta to set up touch panel joint venture with 3M
Mar 11, 01:45
Quanta Computer has announced plans to set up a joint venture with US-based 3M in Singapore for developing projected capacitive touch technology in order to gain profits from the...
Quanta to cooperate with 3M for new touch screen technologies
Jan 11, 02:40
Taiwan-based notebook maker Quanta Computer has announced it will cooperate with US-based 3M over touch screen technologies and will develop a next-generation solution; however, Quanta...
Display Taiwan 2010: 3M showcases multi-touch, 3D and USB-driven displays
Jun 10, 15:36
US-based 3M is showcasing a range of multi-touch, 3D and USB 3.0 display solutions, as well as its DBEF (dual brightness enhancement film) applications at Display Taiwan 2010.
Computex 2010: Quanta announces new touchscreen technology
Jun 2, 14:08
Quanta Computer has announced at Computex 2010 a new touchscreen technology called dispersive signal technology (DST), which the company has co-developed with 3M, and expects to launch...
3M plans to expand BEF capacity in Taiwan
May 19, 15:28
US-based 3M, in view of potential growth in demand from Taiwan-based panel makers, plans to expand production capacity for brightness enhancement films (BEF) at its factory in the...
Taiwan market: Epson to partner with 3M to offer large-format printing service
Aug 21, 16:58
Seiko Epson and 3M will cooperate to provide large-format printing service in the Taiwan market, planning to set up 30 service centers to generate reveneues of NT$104 million (US$3.2...
3M to increase purchases from Taiwan by 10% in 2009, says company executive
Aug 4, 09:55
US-based 3M is switching more of its purchase budget to Taiwan, with purchases from Taiwan expected to increase by 10% in 2009, according to 3M Taiwan managing director George Chao...
Large-size BLU optical film demand grows 22% sequentially in 2Q09, says DisplaySearch
Jul 8, 13:36
Large-size TFT-LCD backlight optical film demand grew by more than 22% sequentially in the second quarter of 2009 to 56 million square meters from 45.9 million square meters in the...
LCD brightness improvement films demand to grow 30% by area in 2009, says DisplaySearch
Apr 14, 11:33
The demand for brightness improvement films used in TFT-LCD backlights will grow by 30% on year to 116 million square meters in 2009 from 89.6 million square meters in 2008, according...
Worldwide front projector shipments grow 15% on-year in 3Q08, says Pacific Media
Nov 3, 12:25
Worldwide front projector shipments topped 1.6 million units in the third quarter of 2008, according to Pacific Media Associates (PMA), representing 15.2% growth over the third quarter...
Optoma and Aiptek make headstart in handheld projector market
Oct 8, 12:24
Competition in the fledgling handheld projector market is heating up, as Optoma and Aiptek International have separately launched their first models, the former adopting the Texas...
Photonics Festival and Display Taiwan expos to kick off in Taipei
Jun 10, 12:06
Photonics Festival in Taiwan 2008, along with Display Taiwan 2008, will kick off on June 12 and run until June 13, at the Taipei World Trade Center (TWTC).
Computex 2008: Aiptek reveals mini projector and camera photo frame
Jun 6, 01:35
Digital camcorder and camera vendor Aiptek recently launched a pocket-size media player and a digital photo frame with a built-in camera at Computex 2008.
BEF price drop benefiting LCD panel makers, says paper
Newswatch - Jun 4, 15:51
The component costs of LCD panel makers are expected to drop as prices for brightness enhancement films (BEFs) have decreased sharply amid a price war triggered by 3M, which has cut...
Taiwan optical film makers under pricing pressure from first-tier competitors
May 28, 10:55
Taiwan's fledgling optical film sector is struggling to fend off a pricing onslaught from first-tier international competitors, according to industry sources.
- Toshiba, SanDisk reportedly among takeover targets of Tsinghua
- Taiwan exports decrease in September, says MOF
- AUO announces management adjustments
- Taiwan LCD driver IC firms look to post more than 10% revenue decreases in 4Q15
- Motech Industries, Tainergy Tech September revenues up
- AUO reports September 2015 consolidated revenues
- Taiwan panel makers show revenue declines for 3Q15
- GLT reports record-high revenues for 3Q15
- SerComm 3Q15 revenues hit record
- Synnex Technology September revenues up on month, down on year
- Everlight Electronics sees sequential growth in September revenues
- Lite-On Technology sees increased September revenues
- Epistar, Lextar Electronics September revenues up on month, down on year
- TAITRONIC 2015 opens in Taipei, Taiwan
- Taiwan market: HTC unveils mid-range Desire 728 dual-SIM
- Yageo, Chilisin report increased September revenues
- Inventec enjoys revenue growth in September
- Korea makers developing more AMOLED products as China ramps up LCD production
- Global industrial energy management system revenues expected to reach US$35.6 billion in 2024, says report
- Gintech revenues drop in September due to capacity relocation
- HTC looks to a turnaround in 4Q15 with new models
- Tablet demand stays weak, say Taiwan IC designers
- Gigabyte reports revenues for September
- Compal reports revenues for September
- Pegatron reports revenues for September 2015
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- 'Smart IoT Testing for Wireless Future' – An enlightenment on IoT testing technologies, innovative applications, and new thinking
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- IoT of tomorrow can change mankind
- Advantest joins with Malaysian OSAT Fabtronic and government group to establish first shared-services lab in Southeast Asia
- Unisys IT Implementation of Unisys Stealth Solution for Data Center Segmentation
- AccuTouch Five Wire Resistive Touchscreens
- Getting the Most Out Of Your Next Generation Digital Security Surveillance System
- Embracing the New Generation Intel Atom Family with DDR3 Memory Support
- Got The Message? Ensuring efficient and reliable delivery of content across a mission critical digital signage network
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- Micron's quarterly sales, profit top analysts' estimates (Oct 2) - Bloomberg
- Chipmaker AMD to cut 500 global jobs, take US$42 million charge (Oct 1) - Reuters
- Foxconn nears deal to control Sharp's LCD business (Sep 25) - Bloomberg
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|The Kingsley Club plays like a pure links golf course. (Courtesy of The Kingsley Club)
KINGSLEY, Mich. -- Mike DeVries didn't design The Kingsley Club as much as he "found" the course on deforested land 20 minutes south of Traverse City.
And that is what excites golf's big-game hunters, attracting them from all directions. Firm all-fescue fairways and the ever-present wind on a raw, exposed site give the 6,931-yard course its distinctive British Open feel. In 2010, Golfweek Magazine rated The Kingsley Club as the 19th-best modern golf course in America.
"For a golf purist, this is as good as it gets," said Jim Hearn, a club member from Houston who summers in northern Michigan. "They found the course on the land. They moved only a little dirt to uncover it."
DeVries, who grew up playing Crystal Downs Country Club in nearby Frankfort, estimates he moved 20,000 cubic yards of dirt, a drop in the bucket compared to most modern playgrounds.
Most of the work came in three places such as the plateau green on the tough-as-nails, par-4 15th and the par-3 16th, a redan hole. The rest is the handiwork of glaciers centuries ago and Mother Nature.
Kingsley, a par 71 that opened in 2001, is essentially a more playable, fun version of Erin Hills, the Wisconsin course that will host the 2017 U.S. Open.
"It plays harder and faster than anything in the state," DeVries said. "It lends to continually changing conditions. Someone hits a drive they hit in a similar place the day before, and it catches a slope and goes somewhere different. Some people don't like that. They think it's not fair. That creates an ever-changing palette of shots."
The quirky bounces and the wildly sloping fairways of Kingsley are just part of a unique golf experience that, for now, offers some limited outside play. The private club allows non-members to play if a PGA Professional calls to make the arrangements. Greens fees are in the $150 range, plus a forecaddie fee.
Members both rave and curse the course's five dynamic par 3s. The greens at the 161-yard second hole and the 171-yard ninth are virtual islands, surrounded by ferocious drop-offs and deep sand pits.
The ninth features two tee complexes, the south tees are behind the eighth green and the west tees off to the right. Missing the green from any direction means judgment day on the scorecard.
Hearn, who estimates he's played roughly half of the world's top 100 courses, loves the course's short par 4s, the 365-yard eighth and the drivable, 292-yard 13th.
"You can take (holes) eight or 13 and put them on any course on the planet, and they would be happy to have them," he said.
The Kingsley Club just might be the most intriguing golf course in the state. It plays like a pure links, with weird bounces and wild lies. It's a fun puzzle to try and solve.
September 13, 2011
Jason Scott Deegan has reviewed more than 700 courses and golf destinations for some of the industry's biggest publications. His work has been honored by the Golf Writer's Association of America and the Michigan Press Association. Follow him on Twitter at @WorldGolfer.
Any opinions expressed above are those of the writer and do not necessarily represent the views of the management.
A round at Royal Links Golf Club in Las Vegas lets you take on replicas of 18 historic golf holes that have been used in the British Open rotation, including three from this year's host, the Old Course at St. Andrews.
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