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You think about creating the next Last.fm, flickr, or Web 3.0 start up? You think London lacks opportunities to meet up and discuss those ideas? Then come to MiniBar.
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Donna Christian Thomas
Okeechobee, FL
Get contact information on Donna Christian Thomas, Okeechobee FL. Find out Donna Christian Thomas's age, gender, possible aliases, associates, professional, and education info.
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Donna Christian Thomas
Donna L Jacobs
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Donna L Thomas
Donna Christian Thomas is in her 50's
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Okeechobee, FL
Emporia, VA
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Donna Christian Thomas
Zodiac SignAquarius
StatusPurchasing Manager at Okeechobee High School
StatusPurchasing Manager at Okeechobee High School
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Donna Christian Thomas Has Lived in 2 States
Florida Address for Donna Christian Thomas
12400 Nx 5xxx Axx
Okeechobee FL
Okeechobee FL
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Okeechobee, FL (11 Addresses)
Emporia, VA
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(863) ***-**** - Clewiston, FL
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(941) ***-**** - El Jobean, FL
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Donna Christian Thomas Has Worked at 1 Place
Company: Okeechobee High School
Title: Purchasing Manager
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Chad Dickerson
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Who's coming and who's going. Tell us about your job move! Receive the Revolving Door Newsletter with expert analysis by email twice a week.No Revolving Door results were found.
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New Etsy Policy Means 3D Printed Items Qualify as Handmade in Spirit - Posted November 5, 2013
(NPR) Etsy has made a dramatic change to its policy about how goods are sourced. No longer are items required to be handmade, but instead must have authorship with the seller. 3D printing is one of the factors influencing this decision. Etsy CEO Chad Dickerson says he hates to lose sellers because... [Inside 3D Printing News]


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|Date / Time
|Tuesday June 09, 2015 @09:19AM
|Chinese Doctor Performs Head Transplants On Mice
|Saturday October 04, 2014 @12:24AM
|First Birth From Human Womb Transplant
|Tuesday September 03, 2013 @07:54AM
|World-First: Woman Becomes Pregnant After Ovarian Tissue Graft
|Tuesday July 02, 2013 @12:51PM
|Neuroscientist: First-Ever Human Head Transplant Is Now Possible
|Thursday April 25, 2013 @08:28AM
|Device Keeps Liver Alive Outside Body For 24 Hours
|Tuesday April 16, 2013 @08:05AM
|Lab-grown Kidneys Transplanted Into Rats
|Friday November 30, 2012 @10:08PM
|7 Jailed In 'Kidney For iPad' Case In China
|Friday October 26, 2012 @07:23PM
|Gut Bacteria Cocktail May End Need for Fecal Transplants
|Tuesday May 01, 2012 @09:04AM
|Doctors Transplant Same Kidney Twice In Two Weeks
|Friday March 30, 2012 @02:15AM
|Maryland Team Completes Most Extensive Face Transplant Yet
|Tuesday February 28, 2012 @09:55AM
|World's First Quadruple Limb Transplant Fails
|Thursday July 07, 2011 @01:36PM
|Spanish Surgeon Performs First Synthetic Organ Transplant
|Tuesday October 19, 2010 @06:09PM
|A Lung Transplant With a Side of Peanut Allergies
|Friday July 30, 2010 @02:22AM
|Man Wants to Donate His Heart Before He Dies
|Sunday July 18, 2010 @07:25AM
|Rat Lung Successfully Regenerated and Transplanted
|Saturday June 26, 2010 @07:40AM
|Stem Cells Curing Burn-Induced Blindness
|Thursday June 24, 2010 @05:25PM
|Rats Breathe Air From Lungs Grown In the Lab
|Tuesday March 16, 2010 @10:31PM
|The State of Robotic Surgery
Understanding is always the understanding of a smaller problem in relation to a bigger problem. -- P.D. Ouspensky


text: Andy Dick on Stage by Hilton Hater at May 31, 2011 10:48 am. Comments At the 3:20 mark of this video, Andy Dick rubs his genitals against an audience member. The man has since sued him for it. This video is no longer available. Please check below for related videos. Edit Delete Follow Andy Dick? Facebook Disqus Star: Andy Dick Related Videos: Andy Dick Videos Related Post: Andy Dick Sued For Grinding Junk Into Dude's Head Uploaded by: Hilton Hater Uploaded: May 31, 2011 Duration: 518 seconds


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General Aviation Accident & Pilot Safety
Ask any pilot, safety is top priority when it comes to flying. General aviation accident prevention is the focus of our NTSB Debriefer. Learn keys to being a safe pilot with the articles below.
Tuesday, December 20, 2011
Air Race Accidents
Safety in air racing depends on the airplane as well as the pilot
The death toll quickly rose to 11, including the pilot with about 70 injured.
Tuesday, November 8, 2011
Fire In Front
In a fire scenario, aircraft control can be lost at any moment
According to a search of NTSB data, in 2010, there were only four general aviation fixed-wing accidents investigated that involved in-flight engine compartment fires.
Tuesday, October 4, 2011
Fuel Imbalance
Wing heaviness may be a minor annoyance or a genuine threat to safety
Most pilots know what it feels like when an airplane is wing heavy because there's more fuel on one side than the other.
Tuesday, September 6, 2011
The Ted Stevens Accident
It looks as if we'll never know exactly what happened
The NTSB says cockpit recorders might have helped shed better light on exactly what happened in the accident in which former U.S.
Tuesday, August 9, 2011
Broken Brakes
There are times when the risk of not stopping should stop you from going
Not too long ago, I was looking forward to an hour or so of poking holes in the sky in a Piper Cherokee 180.
Tuesday, July 5, 2011
Accepting A Bad Situation
It's better to accept a poor outcome than to create a disastrous one
While a pilot needs to evaluate the consequences of making any decision, he or she needs to know that revising a decision is likely to make a bad situation even worse.
Tuesday, June 7, 2011
Getting A Few Winks
There was an outcry after a controller fell asleep, but concerns about tired controllers aren't new
Secretary of Transportation Ray LaHood and FAA Administrator Randy Babbitt led the outcry of indignation when news broke that the lone controller on the overnight shift at Reagan National Airport (DCA) in Washington had fallen asleep
Tuesday, May 10, 2011
How Tight Is Tight?
Even if you're really thorough, you can't always tell during preflight whether something is coming apart
Prominent on its list of Most Wanted Safety Improvements for 2011 is an assessment by the NTSB that the FAA needs to speed up improvements to procedures and equipment in order to help eliminate runway incursions.
Tuesday, April 5, 2011
Adding Air Bags And Harnesses In The Air
We take air bags and shoulder harnesses for granted on the ground
Prominent on its list of Most Wanted Safety Improvements for 2011 is an assessment by the NTSB that the FAA needs to speed up improvements to procedures and equipment in order to help eliminate runway incursions.
Tuesday, March 8, 2011
Close Calls On The Runways
Having a clearance doesn't always guarantee that you're clear
Prominent on its list of Most Wanted Safety Improvements for 2011 is an assessment by the NTSB that the FAA needs to speed up improvements to procedures and equipment in order to help eliminate runway incursions.
Tuesday, February 8, 2011
Midair Over The Hudson
One digit in a radio frequency might have made all the difference
As a result of its investigation of the August 8, 2009, midair collision over the Hudson River, the NTSB says it's time for the FAA to improve the information it offers to pilots about avoiding collisions.
Tuesday, December 21, 2010
Stop Squeezing Them In
The NTSB wants the FAA to change the regs governing required seats and seat belts
Remember the circus act in which a dozen clowns get out of the smallest car you've ever seen drive into the center ring?
Tuesday, November 2, 2010
The Crosswind Component
The principle is the same whether you're flying a 737 or an LSA
Ensuring that there's a safety margin in everything we do is fundamental to aviation accident avoidance.
Tuesday, October 5, 2010
Hazards Of Extreme Flying
You have to know when you're too close to crossing the line
Ensuring that there's a safety margin in everything we do is fundamental to aviation accident avoidance.
Tuesday, September 7, 2010
Buyer Beware
Whether it's a new or used airplane, don't rush when doing your prebuy inspection
You might think that FAA airworthiness, inspection and record-keeping requirements virtually guarantee that any airplane you buy is going to be in superb condition.
Tuesday, August 3, 2010
Great Places Not To Have An Accident
Don't spend so much time looking at scenery that you neglect to look at flight necessities
One of the truly wondrous things about general aviation is the ease with which you can reach vacation sites that would be a hassle via road, ferry or airline transportation.
Tuesday, July 6, 2010
The Light-Sport Safety Record
Tracking 2009 incidents
While the NTSB's preliminary statistics show that the number of general aviation accidents dropped again last year, as did the number of people killed, the estimated number of hours flown also dropped, resulting in a slight increase in both the overall and fatal accident rates.
Tuesday, June 8, 2010
Monitoring What's Going On
Managing pilot workload
Individuals who have passed their FAA written exams and practical tests don't necessarily have the knowledge and skills to become trustworthy pilots.
Tuesday, May 4, 2010
Analyzing Pilot Performance
The NTSB's findings on the Colgan Air crash
NTSB investigators were able to assemble plenty of data to reconstruct what happened on board the Colgan Air Bombardier DHC-8-400 that crashed at Clarence Center, N.Y., on February 12, 2009.
Tuesday, April 6, 2010
Recognizing You're In Trouble
Fatigue can cause pilots to fall behind
One of the most important skills for pilots to possess is the ability to recognize when they're falling behind in an unfolding scenario. Frequently, pilots who fall too far behind experience accidents and are immortalized in NTSB accident reports.


text:
eNotes Homework Help is a way for educators to help students understand their school work. Our experts are here to answer your toughest academic questions! Once it's posted to our site, your question could help thousands of other students.
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Cold WarIt is impossible to say with absolute certainty what Europe would have looked like by 1960 if the post-World War II policies for economic recovery in war-torn Western Europe and the policy of...
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Marshall PlanThe United States advocated this plan as a way to contain communism. After WWII, the economies of Western Europe were devastated. The bombing and other fighting had destroyed much of the physical...


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Burberry Brit's mid-weight stretch-cotton shorts have turned-up cuffs and an adjustable waist for a precise fit. Wear this pleated style on vacation with a silk tank and leather sandals.
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Great product better than original equipment from the Toyota dealer. Toyota should switch to this product! this is the third time the original from the dealer has broken. this one is all metal, probably will outlast my Toyota Sequoia.
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text:
Scott Hartsman Reflects on One Year of Rift
RIFT gets ready to celebrate its first anniversary and Scott Hartsman reflects on the games first year of live operation and plans for 2012.
Hard as it may seem, RIFT is about to turn one year old and Executive Producer Scott Hartsman has posted a new letter to the community reflecting on the games first full year of operation and where Trion plans to go from here.
Moving forward into 2012, Hartsman laid out Trions plans for RIFT to expand on making friend and playing with other people in easier ways, improving the Ascended Soul system, enhancing PvP, adding more social options and endgame content. Hartsman also teased that more details about what players will face after the planar dragons have all been dealt with will be revealed later this year, so stay tuned.
Source: RIFT: One Year Later
To read the latest guides, news, and features you can visit our RIFT Game Page.


text:
Has same effect as beta blocker drugs in 40% of blacks, study finds
MONDAY, April 21 (HealthDay News) -- Researchers have discovered a gene variant carried by about 40 percent of blacks that protects them after heart failure as much as widely used beta blocker drugs do.
The finding explains the puzzling results reported in trials of beta blocker therapy in black people, said Dr. Stephen B. Liggett, a professor of medicine and physiology at the University of Maryland, and co-author of a report in the April 20 online issue of Nature Medicine.
"To our knowledge, this is the first case where a genetic variant mimics the activity of a drug used to treat a disease," Liggett said.
But Liggett predicted "further surprises" along the same lines as research on human genetic variations continues.
The finding won't have an immediate effect on treatment of heart failure, the progressive loss of ability to pump blood that affects an estimated 5 million Americans, said study co-author Dr. Gerald W. Dorn II, director of the Center for Pharmacogenomics at Washington University in St. Louis. Doctors can continue to prescribe beta blockers for people with heart failure, black or white, since the drugs have little risk, he said.
But there should be an effect on future medical practice, Dorn said. "One idea in the future of drug discovery is that we will not only need to tailor therapy for individual genetic makeup but also take genetic makeup into consideration in drug testing," he explained.
About 2 percent to 3 percent of white Americans in the total group of 2,000 who were tested carried the gene variant, he said.
The research finding was made possible by the Human Genome Project, which laid out all the more than 20,000 genes that act in humans. The researchers zeroed in on the gene pathway responsible for the activity of adrenaline, a hormone that increases cardiac output. In heart fa
|Copyright©2008 ScoutNews,LLC.
All rights reserved


text:
Why is the Godfather of Gore's horror-cheapie classic included in this program, you ask? It dealt with a dead Confederate army that rises from the grave and attacks Northerners. It was made in the year of the Freedom Summer and the violent deaths of three civil-rights workers in Mississippi. You figure it out.
Two Thousand Maniacs
|Event website:


text:
May 27, 2014, 7:13 AM
- China Automotive Systems, Inc. (CAAS) declares $0.18/share special dividend.
- Payable July 28; for shareholders of record June 26; ex-div June 24.
CAAS vs. ETF Alternatives
Company Description
China Automotive Systems Inc is a holding company. The Company through its subsidiaryis engaged in manufacturing and sale of automotive systems and components.
Sector: Consumer Goods
Industry: Auto Parts
Country: China
Other News & PR
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text:
Page 1
Epilepsia, 49(7):1123–1141, 2008
doi: 10.1111/j.1528-1167.2008.01665.x
Rufinamide: Clinical pharmacokinetics
and concentration–response relationships
in patients with epilepsy
∗Emilio Perucca, †James Cloyd, ‡David Critchley, and §Eliane Fuseau
∗Institute of Neurology IRCCS C. Mondino Foundation and Clinical Pharmacology Unit, University of Pavia, Pavia,
Italy; †Center for Orphan Drug Research, University of Minnesota, Minneapolis, Minnesota, U.S.A.; ‡Eisai Ltd,
Hammersmith, London, United Kingdom; and §EMF Consulting, Aix-en-Provence, France
Rufinamide is a new, orally active antiepileptic drug
(AED), which has been found to be effective in the
ciated with the Lennox-Gastaut syndrome. When
taken with food, rufinamide is relatively well ab-
sorbed in the lower dose range, with approxi-
mately dose-proportional plasma concentrations
up to 1,600 mg/day, but less than dose-proportional
plasma concentrations at higher doses due to re-
duced oral bioavailability. Rufinamide is not exten-
sively bound to plasma proteins. During repeated
tent with its elimination half-life of 6–10 h. The ap-
parent volume of distribution (Vd/F) and apparent
oral clearance (CL/F) are related to body size, the
best predictor being body surface area. Rufinamide
is not a substrate of cytochrome P450 (CYP450)
enzymes and is extensively metabolized via hydrol-
ysis by carboxylesterases to a pharmacologically in-
active carboxylic acid derivative, which is excreted
in the urine. Rufinamide pharmacokinetics are not
affected by impaired renal function. Potential dif-
ferences in rufinamide pharmacokinetics between
children and adults have not been investigated sys-
tematically in formal studies. Although population
pharmacokinetic modeling suggests that in the ab-
sence of interacting comedication rufinamide CL/F
may be higher in children than in adults, a mean-
ingful comparison of data across age groups is com-
plicated by age-related differences in doses and in
proportion of patients receiving drugs known to
increase or to decrease rufinamide CL/F. A study
investigating the effect of rufinamide on the phar-
macokinetics of the CYP3A4 substrate triazolam
and an oral contraceptive interaction study showed
that rufinamide has some enzyme-inducing po-
tential in man. Findings from population pharma-
cokinetic modeling indicate that rufinamide does
not modify the CL/F of topiramate or valproic
acid, but may slightly increase the CL/F of carba-
CL/F of phenobarbital and phenytoin (all predicted
changes were <20%). These changes in the phar-
macokinetics of associated AEDs are unlikely to
make it necessary to change the dosages of these
AEDs given concomitantly with rufinamide, with
theexception thatconsiderationshouldbegivento
reducing the dose of phenytoin. Based on popula-
tion pharmacokinetic modeling, lamotrigine, top-
iramate, or benzodiazepines do not affect the
pharmacokinetics of rufinamide, but valproic acid
may increase plasma rufinamide concentrations,
especially in children in whom plasma rufinamide
concentrations could be increased substantially.
Conversely, comedication with carbamazepine, vi-
gabatrin, phenytoin, phenobarbital, and primidone
was associated with a slight-to-moderate decrease
in plasma rufinamide concentrations, ranging from
a minimum of −13.7% in female children comedi-
cated with vigabatrin to a maximum of −46.3% in
female adults comedicated with phenytoin, pheno-
barbital, or primidone. In population modeling us-
ing data from placebo-controlled trials, a positive
Accepted April 10, 2008; Online Early publication May 22, 2008.
Address correspondence to David Critchley, Eisai Ltd, 3 Shortlands,
Hammersmith, W6 8EE, U.K. E-mail: david email@example.com
Wiley Periodicals, Inc.
C ?2008 International League Against Epilepsy
Page 2
E. Perucca et al.
correlation has been identified between reduction
in seizure frequency and steady-state plasma rufi-
namide concentrations. The probability of adverse
effects also appears to be concentration-related.
Gastaut syndrome, Drug interactions, Pharmaco-
dynamics, Population modeling, Seizure frequency.
WORDS: Antiepilepticdrug, Lennox-
Many patients with epilepsy continue to have seizures
despite treatment with currently available antiepileptic
drugs (AEDs). Lennox-Gastaut syndrome (LGS) is a par-
ticularly intractable form of epilepsy for which current
treatment options, which include valproic acid, lamot-
rigine, topiramate, and felbamate, are often inadequate
(Schmidt & Bourgeois, 2000). Rufinamide, a triazole
derivative, is a new, orally active AED that is structurally
unrelated to existing anticonvulsants (Fig. 1) (Eisai data
on file: Study HPH9213, 1996). In experimental mod-
els, rufinamide has been shown to suppress neuronal hy-
perexcitability by prolonging the inactivation phase of
voltage-gated sodium channels (CNS) (Eisai data on file:
Study RD-2000-00305, 2000; Eisai data on file: Study W-
20050136, 2000). In in vitro studies, rufinamide showed no
interactions with benzodiazepine or gamma-aminobutyric
acid (GABA) receptors, 5-HT1and 5HT2receptors, α- or
β-adrenoceptors, or human recombinant metabotropic glu-
tamate receptor subtypes 1b, 2, or 4 (mGluR1b, mGluR2,
mGluR4) (Eisai data on file: Study NO1-NS-4–2361,
1987; Eisai data on file: Study BR 58/87, 1987; Eisai data
on file: Study RD-2000–00575, 2000). However, an in-
hibitory effect at the mGluR5 subtype was observed at rel-
atively high concentrations (60% inhibition of quisqualate-
induced phosphoinositol turnover at 100 μM rufinamide)
(Eisai data on file: Study RD-2000–00575, 2000), which
might contribute to the seizure-suppressing activity of
the drug. Anticonvulsant effects of rufinamide have been
demonstrated in several animal models, including seizures
induced by maximal electroshock, various chemoconvul-
sants, and amygdaloid kindling. In these models, rufi-
namide shows a high protective index (i.e., a high ratio be-
tween the neurotoxic and the effective dose) (Eisai data on
file: Study BR-294, 1981; Eisai data on file: Study PHA
(EB 3/1986), 1986; Eisai data on file: Study NO1-NS-4–
2361, 1987; Eisai data on file: Study BR-59/88, 1988White
et al., 2005). Conventional safety pharmacology studies re-
vealed no safety hazards considered to be of relevance for
clinical use (Eisai Pharmaceutical Ltd., 2005).
Rufinamide has beengranted Orphan Drugstatusinboth
the European Union and the United States for the treat-
ment of seizures associated with LGS (EMEA, 2004; FDA,
2004). In Europe, rufinamide has been granted a market-
ing authorization for adjunctive therapy in the treatment
of seizures associated with LGS in patients aged 4 years
and older. It is currently being evaluated by regulatory au-
thorities in the United States for adjunctive treatment of
both LGS and partial-onset seizures with and without sec-
ondary generalization in adults and adolescents. The dos-
ing recommendations approved by regulatory authorities in
Europe are 200–1,000 mg/day for patients without valproic
acid comedication weighing <30 kg, 200–600 mg/day for
patients comedicated with valproic acid weighing <30 kg,
and 400–1,800 mg/day, 400–2,400 mg/day, and 400–
3,200 mg/day for patients weighing 30–50 kg, >50–70 kg,
and >70 kg, respectively.
This article reviews currently available data on rufi-
namide clinical pharmacokinetics and drug interactions,
as well as preliminary information on correlations be-
tween plasma rufinamide concentrations and clinical ef-
fects. The vast majority of the individual studies reported
here have not been published. A synopsis of studies to-
gether with data cited herein are available on request
from Eisai Ltd., 3 Shortlands, Hammersmith, London, W6
Clinical studies and formulations tested
The clinical pharmacology of rufinamide has been eval-
uated using various formulations in healthy subjects, sub-
jects with renal impairment, and patients with epilepsy.
Studies evaluating rufinamide pharmacokinetics using the
commercial formulation are summarized in Table 1. The
formulation selected for the commercial product is a film-
coatedtabletcontaining 100,200,or400mgofrufinamide.
During development, several production processes were
developed. One of these, roller compaction, was used in
early studies but was not compatible with the need to
produce 400-mg tablets. Rufinamide tablets prepared by
wet granulation without predensification/wetting were also
used in some studies. Subsequently, the method of wet
granulation with predensification was adopted. This for-
mulation, which was used in several large Phase II/III stud-
ies, such as Studies 016, 018, 021, and the LGS Stud-
ies 022 and 022E (Table 1) (Eisai data on file: Study
HPH9213, 1996; Eisai data on file: Study 015, 1997;
Eisai data on file: Study 036, 1999; Eisai data on file:
Study 037, 1999; Eisai data on file: Study 102, 2000;
Eisai data on file: Study E2080-A001-001, 2005; Eisai data
on file: Report EMFFR2004/014/01, 2005; Eisai data on
file: Report EMFFR2004/019/00, 2005), was ultimately
selected for commercialization and is referred to here-
after as the "commercial formulation." A liquid suspen-
sion is also in development but was not used in the studies
reported here.
Epilepsia, 49(7):1123–1141, 2008
doi: 10.1111/j.1528-1167.2008.01665.x
Page 3
Pharmacokinetics and Pharmacodynamics of Rufinamide
Figure 1.
Metabolism of rufinamide (Eisai data on file: Study HPH9213, 1996). The pie graph shows recoveries of parent drug
and its metabolites in urine and feces based on data obtained in three healthy male subjects who took14C-rufinamide
by mouth (3 × 200 mg gelatine capsules with food).
Epilepsia C ?ILAE
In eleven studies, healthy subjects received single doses
of rufinamide ranging from 100 to 2,100 mg, including one
study comparing elderly and young subjects (Study 031).
Five multiple-dose studies were conducted in healthy sub-
jects, including two using the commercial formulation: one
in subjects with impaired renal function (Study 029), and
another that investigated maximal tolerated doses of rufi-
namide in 15 healthy subjects (Study E2080-A001-001).
In this study, rufinamide was given with food at doses of
400–3,600 mg twice daily (bid) over a period of 18 days
(Eisai data on file: Study E2080-A001-001).
Three multiple-dose studies evaluated the potential for
specific pharmacokinetic drug interactions in healthy sub-
jects (Studies 014, 104, and 105), two of which used the
commercial formulation.
Seven safety and efficacy studies in children (from 2 to
11 years), adolescents (from 12 to 17 years), and adults
with epilepsy were included in a pooled population analy-
sis; all were multicenter, randomized, parallel-group stud-
ies, five were placebo-controlled, and five used the com-
mercial formulation (Table 1) (Eisai data on file: Report
Pharmacokinetic analyses
In studies formally designed to characterize the pharma-
cokinetics of rufinamide after single and multiple dosing,
noncompartmental analyses were applied to derive phar-
macokinetic parameters, including maximum plasma con-
centration (Cmax), time to maximum plasma concentration
(Tmax), area under the concentration–time curve from time
zero to time t (AUC0–t) or infinity (AUC0–∞), elimination
half-life (t1/2), apparent oral clearance (CL/F, where F is
the oral bioavailability) and apparent volume of distribu-
tion (Vd/F).
The pharmacokinetics of rufinamide and concomi-
tant AEDs were also assessed using population phar-
macokinetic nonlinear mixed-effects modelling (NON-
MEM) (see Effects of intrinsic factors on rufinamide
Epilepsia, 49(7):1123–1141, 2008
doi: 10.1111/j.1528-1167.2008.01665.x
Page 4
E. Perucca et al.
Table 1. Summary of studies investigating the pharmacokinetics of rufinamide in healthy subjects,
patients with renal impairment, and patients with epilepsy
Study code
Single-dose pharmacokinetic
(Eisai data on file: Study
(Eisai data on file:
Study 015, 1997)
(Eisai data on file:
Study 036, 1999)
(Eisai data on file:
Study 037, 1999)
Participants and designN Study duration Rufinamide doses
Healthy male subjects. Open-label, single-center study3 Single dose
14C-labelled 600 mga
(with food)
Healthy subjects. Cross-over study comparing roller
compacted and commercial formulations
12 Single dose600 mg
(with high-fat meal)
Healthy subjects. Cross-over study of low, medium and
high bulk density tablets.
24 Single dose 400 mg
(with food)
Healthy subjects. Cross-over study of fasting versus fed
12 Single dose200 or 400 mg
(fasting vs. fed)
Healthy subjects. Cross-over study of fed and fasting
24 Single dose400 mg
(Eisai data on file:
Study 102, 2000)
Multiple-dose pharmaco-
kinetic studies
(Eisai data on file: Study
Studies in patients with
Pooled population analysis
(Eisai data on file:
Report EMFFR2004/
(fasting vs. fed)
Healthy subjects. Rising-dose safety study 2018 days 800–7,200 mg/day
(bid with food)
Patients with inadequately controlled partial seizures
with or without secondary generalized seizures.
Multicenter, double-blind, randomized, parallel-group
Patients with inadequately controlled primary
generalized tonic–clonic seizures. Double-blind,
randomized, placebo-controlled, parallel-group study
Patients with inadequately controlled partial seizures.
Double-blind, randomized, placebo-controlled,
parallel-group study
Patients with inadequately controlled partial seizures.
Double-blind, randomized, placebo-controlled,
parallel-group study
Adults/children with inadequately controlled
Lennox-Gastaut syndrome. Double-blind,
randomized, placebo-controlled, parallel-group study
142 7 days titration
and 105 days
300; 3,200 mg/day (bid,
timing with respect to
food not specified)
155 140 days
800 mg/day (or placebo) (bid
with food)
021 (adult stratum)
313 14 days titration
and 77 days
14 days titration
and 77 days
14 days titration
and 70 days
3,200 mg/day maintenance
dose (or placebo) (bid
with food)
45 mg/kg/day maintenance
dose (or placebo) (bid
with food)
45 mg/kg/day maintenance
doseb(or placebo) (bid
with food)
021 (pediatric stratum)
Studies in the elderly
031 Elderly subjects
Young healthy subjects.
Open-label, parallel-group study
8 daysDay 1: 400 mg; Days 4–7:
800 mg/day; Day 8: 400 mg
Studies in the renally
029 Renally impaired subjects
Healthy subjects.
Open-label, parallel-group study
Single dose 400 mg
(single doses with food)
Drug–drug interaction
0104Healthy subjects. Open-label, 3-period trial to evaluate
effects on triazolam pharmacokinetics.
1815 daysDays 4–14: 800 mg/day (bid
with food) (Single
triazolam doses on days 1
and 15)
Epilepsia, 49(7):1123–1141, 2008
doi: 10.1111/j.1528-1167.2008.01665.x
Page 5
Pharmacokinetics and Pharmacodynamics of Rufinamide
Table 1. Continued
Study code
Participants and designN
Study duration
22 days
Rufinamide doses
Days 11–22: 800 mg/day (bid
with food) (Single
olanzapine doses on days 1
and 22)
Healthy subjects. Open-label, 3-period trial to evaluate
effects on olanzapine pharmacokinetics.
Pooled population drug-
interaction analysis
(Eisai data on file:
Report EMFFR2004/
019/00, 2005)
18, 21, and 22
See description of individual studies, above.
Patients with inadequately controlled partial seizures,
receiving 1–3 AEDs. Double-blind, randomized,
placebo-controlled, parallel-group study
6473 months
and long-term
28 days
followed by
200, 400, 800, 1600 mg/day
(or placebo)
Patients with primary generalized tonic–clonic, simple,
complex partial seizures ± secondary generalization.
Double-blind, randomized, placebo-controlled,
parallel-group, weekly rising-dose study
400–1600 mg/day (or
placebo) during double
blind. 800 mg during
For clarity, only studies using the final commercial formulation are listed (except where shown), although data from all studies,
irrespective of formulation, were included in the pooled pharmacokinetic–pharmacodynamic model, with suitable adjustments for
the differences in bioavailability.
AED, antiepileptic drug.
aCapsule;bWet granulation without predensification for 200 mg tablets;cRoller Compaction Formulation.
The commercial formulation was made by wet granulation with predensification.
pharmacokinetics: Renal and hepatic impairment). The
data set used for pharmacokinetic analysis included 5,937
rufinamide concentrations from 1,072 patients. Concomi-
tant medications in the pharmacokinetic population (n =
1,072) included carbamazepine (616 patients), valproic
acid (270 patients), lamotrigine (109 patients), vigabatrin
nobarbital, or primidone (271 patients). Data from these
patients were standardized and pooled to produce a sin-
gle dataset. This was then used to evaluate the effects of
these AEDs on the pharmacokinetics of rufinamide using
the dose and/or concentration of each concomitant AED as
a covariate (Eisai data on file: Report EMFFR2004/014/01,
The potential for rufinamide to influence the pharma-
cokinetics of concomitant AEDs was determined using
data from a total of 1,573 patients receiving stable doses of
AEDs at entry into Studies 018, 021 (both paediatric and
adult strata), 022, AE/ET1, and AE/PT2. Studies lacking
a placebo control group (i.e., Studies 016 and 027) were
not included in this analysis. The most commonly used
concomitant AEDs for patients included in this population
were carbamazepine (n = 903), valproic acid (n = 488),
lamotrigine (n = 200), topiramate (n = 69), phenobarbital
(n = 149), and phenytoin (n = 299) (Eisai data on file:
Report EMFFR2004/019/00, 2005). For each AED ana-
lyzed, CL/F was estimated using a linear pharmacokinetic
model. Nonlinear models were also tested in order to ex-
amine the effect of dose on CL/F. Appropriate scaling fac-
tors were determined by testing a variety of factors in turn
and choosing the factor that allowed best fitting of the data.
Age was used as the scaling factor to adjust CL/F among
children, adolescents, and adults for carbamazepine, topi-
ramate, and valproic acid, while body weight was found to
be the best-fit scaling factor for lamotrigine, phenobarbital,
and phenytoin.
Pharmacokinetic/pharmacodynamic (PK/PD) analyses
The relationships between pharmacokinetic variables
and clinical response were investigated using popula-
tion PK/PD analyses with data from seven studies in
patients with epilepsy (Studies AE/ET1, AE/PT2, 016,
018, 021, 022, and 027) (Eisai data on file: Report
EMFFR2004/014/01, 2005). This population included
placebo recipients, and comprised a total of 1,725 patients,
of whom 243 were children and 191 were adolescents. The
population modeling used allows information from many
sources to be collected together and analyzed to deter-
mine whether the data derived from different populations
differ or not. If they differ, then different PK/PD models
are appropriate and can be developed from the data and
tested until the best-fit solutions are found. If the results do
not differ substantially, then it can be inferred that a sin-
gle model describes all situations. The data on which the
PK/PD model was based included information about the
type of epilepsy for each subject, which allowed the dose–
response relationship to be modeled for different seizure
types and epilepsy syndromes (see Details of mixed-
effect modelling analysis). Seizure types assessed were
Epilepsia, 49(7):1123–1141, 2008
doi: 10.1111/j.1528-1167.2008.01665.x


text:
Chicago cop accidentally shot in leg by fellow officer
Responding to a burglary-in-process, an officer fired at a vicious dog, accidentally also shooting his partner
The Chicago Tribune
CHICAGO — A Chicago police officer was shot in the leg by a fellow officer who had fired at a charging dog Monday night in the Englewood neighborhood, authorities said.
Two officers and a supervisor went to the second-floor landing of the building, where they were confronted by a "vicious dog," according to police.
When the dog charged toward them, an officer fired a single shot that struck the dog and also hit another officer in the thigh, according to a police source. Paramedics took the 42-year-old officer in good condition to John H. Stroger, Jr. Hospital of Cook County, where he was treated and released.
Full Story: Police officer accidentally shot in leg by fellow cop
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text:
The Sony RX10 II is the follow-up to a camera we already thought quite highly of. While the 24-200mm F2.8 equivalent lens and external body design remain unchanged, the RX10 II sports a new stacked sensor and can record 4k video internally, with full sensor readout. It also features improved AF performance and a higher-res EVF, but is it worth the sticker price? Read more
PIX 2015 VideosPhotography talks, demos and panelsFirst-impressions ReviewSony Alpha 7R II Review1.08K
Featured Review
October 13
Lomography has introduced the Lomo'instant Wide camera. Using Fujifilm Instax Wide film, the camera offers a 35mm equivalent lens and Auto, Bulb, and 1/30sec Fixed Shutter Speed modes. Features cater to those who want to take a little more control over their instant prints, including a multi-exposure button and a lens cap that functions as a shutter remote control. Read more
The camera in the new Apple iPhone 6s comes with an increased pixel count, better responsiveness and an updated panorama mode. Our friends at DxO have just released their full report on the iPhone 6s camera, and you can read the whole thing at our sister site, Connect. Read more
Canon has dropped a trio of new cameras on the world - one mirrorless and two fixed lens - and we wanted to give you a quick summary of the most interesting features are for each of them. Keep reading if you've got a hankering for more about the EOS M10 or the PowerShot G5 X and G9 X. Read more
Canon has introduced two new enthusiast compacts with 1"-type CMOS sensors: the PowerShot G5 X, which will sit above the PowerShot G7 X, and the entry-level G9 X which is roughly the size of the PowerShot S120. Read more
The Canon EOS M10 makes its debut with a new collapsible 15-45mm F3.5-6.3 IS kit lens, taking up residence below the more advanced EOS M3 in that company's mirrorless lineup. A replacement for the M2, the M10 offers an 18MP CMOS sensor, 3" 1.04M dot tilting touch screen LCD, built-in Wi-Fi with NFC and 1080/30p video recording. Read more
October 12
ZEISS has introduced the 21mm F2.8 to its Loxia lineup for full-frame Sony E-mount cameras, joining the 35mm F2 and 50mm F2. Like its siblings, the 2.8/21 allows the user to de-click the aperture ring for video recording. Read more
Adobe has issued an apology over the 'significant crashing bug' introduced in Lightroom 6.2. The latest version of the software was released last Monday, and brought with it a redesigned import experience. That new experience, unfortunately, also introduced instability into Lightroom and removed some import functions; users reported issues with the software crashing and running poorly. Read more
October 11
Australia-based conceptual artist Colin Anderson is re-defining what it means to be a modern photographer. An early adopter of Photoshop, Anderson creates complex allegorical images from a number of visual elements, including stills captured with a medium format camera and 3D elements created from scratch. Find out what he's learned from a long career in editorial and commercial photography. Read more
October 9
Voigtländer has introduced three new lenses that will be released in Spring 2016: the 10mm F5.6 Hyper-Wide-Heliar, 12mm F5.6 Ultra-Wide-Heliar, and 15mm F4.5 Super-Wide-Heliar. All three lenses will feature a Sony E-mount for use with full-frame Sony cameras without an adapter. Read more
Seattle-based band Ever So Android are an indie rock trio who have played all over the western USA. Their energetic live shows pack venues throughout the year in their hometown, but recently, they performed their single 'Moment' for a different crowd: a small crew of filmmakers armed with Samsung NX1 and NX500 cameras, led by directors Brad Strain and Matt Kumasaka. Read more
October 8
US-based startup Light has officially introduced its L16, a portable device packed with 16 individual cameras, ten of which capture an image at the same time at different fixed focal lengths. The resulting photograph is a composite of all the individual images combined, with a final resolution of up to 52 megapixels. An earlier prototype of this camera was shown off this past April. Read more
The iPhone 6S doesn't look too different from the iPhone 6 that it replaces, but its camera module has been significantly improved. Now offering 12MP and snappier performance, the camera on the iPhone 6S is impressively capable. We've been out and about with the new phone, taking plenty of pictures in a range of different situations. Click through to see our gallery of real-world samples
October 7
Sony Corporation is to split the part of its business that makes imaging sensors away from the Devices segment that it currently comes under, to form its own company called Sony Semiconductor Solutions Corporation. Sony has said that the degree of autonomy that the new company will enjoy will allow it to react more quickly to changing market forces and will encourage the business to grow more quickly. Read more
Manfrotto has launched the Pixi Evo, a miniature lightweight tripod with two-section legs and five adjustable steps. The Pixi Evo represents a design update over the original Pixi mini tripod, and is designed, in part, to support entry-level DSLRs with large lenses. Read more
PIX 2015 has given us the opportunity to do something we've wanted to do for a long time: present awards recognizing the significant bits of photographic gear that have been announced in the last year. We handed them out last night, see which products were winners. Read more
Day one of our PIX 2015 re:FRAME speaker lineup wrapped up with a moving keynote presentation from Cristina Mittermeier. Read more
October 6
Adobe has released Camera Raw 9.2, introducing a local version of its new dehaze adjustment. ACR 9.2 also adds support for the DxO ONE, though not for the camera's SuperRAW files. Other cameras supported by the update are the Olympus OM-D E-M10 II, Sony Alpha 7S II and Leica S (Typ 007). Read more
Today Microsoft not only launched two new smartphones with PureView camera, but also the latest incarnation of its high-end Surface Pro tablet capable of running full desktop apps, such as Adobe Photoshop CC or Lightroom. Read more
October 5
In addition to two days of speakers, demos and photo activities, PIX 2015 is also a miniature film festival. We're excited to partner with the Seattle International Film Festival (SIFF), who are presenting some of their favorite recent photography-centric movies. Read more
Project Apollo Archive has uploaded a massive library of high-resolution photos taken during NASA's moon missions and related training exercises. More than 8,400 photos have been published, including scans of original photos taken by astronauts' Hasselblad cameras and some processed photos from film magazines. Read more
Our in-depth testing of the Sony Alpha 7R II continues, and we've just published 3 pages of Raw dynamic range analysis. Along with AF, the a7R II's dynamic range capabilities have been the subject of much attention and could help put Sony's latest full frame camera at the top of its field. Take a look and see how the a7R II's 42MP BSI CMOS sensor performs when its Raw files are pushed to the limit. Read more
Adobe has officially launched Photoshop Fix, a mobile app it demoed at Apple's iPad Pro launch in early September. Available today for iPad and iPhone, Photoshop Fix brings tools like the healing brush and liquify to mobile devices along with adjustments like paint and defocus. Read more
DPReview's first major event - PIX 2015 - kicks off tomorrow! The best news? You don't even have to book a last-minute flight to Seattle to participate. Starting Tuesday at 9:30AM PT, you can tune in right here and be part of the experience, or watch the archived content later, at your convenience. Read more
October 4
It's hard to believe that PIX 2015 is only a couple of days away. As we get closer to the show, we're highlighting some of our amazing speaking and content partners. In the slideshow above you'll find a preview of some of the iconic photos Getty Images will have on display in our gallery space. Find out more about the Legacy Collection from Getty Images Co-Founder Jonathan Klein. Read more
October 3
It's hard to believe that PIX 2015 is a few days away! Take a peek behind the scenes before the curtain rises on our photography expo. Show attendees will have plenty of opportunities for hands-on photo experiences, as well as a chance to take a look at how far digital photography has come. The DPReview Experience booth will host a digital photography timeline featuring iconic digital cameras and media storage devices - see a few of them highlighted here. Read more
October 2
With its 5.7-inch QHD AMOLED display the Nexus 6P is a little smaller than last year's Nexus 6 in terms of both display size and overall dimensions. It comes with an aluminum shell and overall high-end specs, along with a new 12.3MP Sony sensor and an F2.0 aperture. DxOMark's mobile evaluation puts it at third place in its rankings - find out why. Read more
The DxO One camera is now available to customers in Europe. The company had announced at the beginning of September that it would launch its camera for European customers in October, having first launched the product for US buyers last month. Read more
When the original iPad was launched, speculation began about when tablets would replace laptops for most users. That has yet to happen, and in the hands of photographers tablets are more often used for presentation rather than image editing. The iPad Pro has the hardware to become a serious image editing device, but will it become one in reality? Lars Rehm weighs in. Read more
With less than a week until PIX 2015, we think you should meet some of our talented re:FRAME speakers. Rick Sammon is a veteran wildlife and travel shooter who has made it a focus of his career to help educate and inspire new photographers. Read more
October 1
TinyMOS, a startup formed by National University of Singapore students, has introduced its Tiny1, a camera designed for astrophotography. The camera was introduced earlier this month at TechCrunch Disrupt 2015, and claims to be the first-ever portable consumer-level astronomy camera. Read more
Replacing the 2014 Moto X, Motorola's flagship Moto X Style has received a complete overhaul in the camera department. It comes with a Sony IMX 230 1/2.4-inch 21MP BSI CMOS sensor and a dual-LED flash, while an F2.0 aperture and 4K video recording remain unchanged from the predecessor. We put its camera through our range of studio and field tests for this full review. Read more
Attorney at Law Bert Krages specializes in issues of intellectual property for photographers and artists. We'll be speaking to him at PIX in a few days, and now is your chance to have a say in the conversation. Read more
September 30
The forthcoming Ricoh GR II is set to also be available in a special limited edition 'Premium' kit that has been announced by the company to mark the 10th birthday of the first digital version of the famous GR film bodies. The kit will come in an aluminum case and will include the GV-1 external viewfinder as well as the GW-3 wide angle converter that uses a 0.75x magnification to turn the camera's 28mm lens into what seems like a 21mm super wide. Read more
Corel has introduced a trio of new versions of its video editing software applications: Pinnacle Studio 19 Ultimate, Pinnacle Studio 19 Plus, and Pinnacle Studio 19. A couple new features have been added to the software, including a new Multi-Camera Editor in each version of the application. In addition, the latest version offers support for 6th-generation Intel Core i7 processors. Read more
DxOMark has published its test results for the Sony Xperia Z5, a high-end smartphone with a 23MP 1/2.4" BSI CMOS sensor, F2.0 lens and dual-LED flash. Calling its hybrid AF system 'impressive in all conditions,' the Z5 takes the top spot in DxO's rankings, sending the Samsung S6 Edge to second place. Read more
Fujifilm has added to its instant camera lineup, introducing the INSTAX Mini 70. The Mini 70 features a sleek re-design, a mirror on the front panel for selfie-framing, and automatic exposure with flash for better balanced low-light photos. Read more
In an interview for Adobe's blog, NASA has revealed some of the processes its scientists use to transform technical data into images that the rest of the world can appreciate and understand. From simple tasks, such as straightening and cropping, to compositing multiple layers of scientifically calculated color, the agency uses programs including Adobe Photoshop to interpret the sometimes quite abstract images sent back to Earth from devices such as the Hubble Space Telescope and the Mars rover. Read more
We're less than a week away from PIX 2015, and we're taking the opportunity to introduce you to some of our talented re:FRAME speakers. Dixie Dixon acquired her first camera, a Nikon FG, when she was just 12 years old. Now she's made a name for herself in fashion and commercial photography - find out a couple of her tips on breaking in. Read more
September 29
A new device called the PanoCatcher is described as a 'robotic photography platform,' and is designed to automate the capture of time lapses, panoramas, and other similar photos. The device is made from CNC precision-machined aluminum, and is compatible with most mirrorless and DSLR cameras. Read more
Google has today launched two new Nexus showcase-devices, giving consumers more choice in terms of device dimensions after last year's 6-inch Nexus 6 wasn't universally well received for its large size, among other reasons. The Nexus 5X is made by LG and seen as an upgrade to the original Nexus 5 from two years ago, and the Nexus 6P is made by Huawei. Read more
Just when you thought HTC's smarpthone line-up couldn't get any more confusing, the Taiwanese manufacturer has launched two new models, both with a focus on camera capabilities and performance. Read more
As far as pocketable cameras go, the DxO ONE is the most likely to fit into the smallest of pockets. Built as a companion to Apple mobile devices, it connects directly via integrated Lightning connector to bring your iPhone a 20MP 1"-type sensor and 32mm equivalent F1.8 lens. We put its standard shooting mode as well as its SuperRAW mode up against our studio test scene. Read more
With just a week until PIX 2015, we're taking the opportunity to introduce you to some of our talented re:FRAME speakers. As a veteran photojournalist, Jonathan Alcorn has acquired some impressive clients on his resume including Reuters, Bloomberg, Getty Images and the New York Times, among many more. Read more
Ricoh has introduced a pair of underwater cameras to its WG range that feature enhanced color control for still and movie photographers. The Ricoh WG-40 and WG-40W, which are being released only in Japan at the moment, are very much like the current Ricoh WG-30 and WG-30G models, but offer a new Mermaid mode that boosts contrast and reds when used underwater. Read more
September 28
It seems 360-degree videos might be here to stay. In March, Youtube started to support the immersive video format, and now Facebook has introduced the technology as well. Soon, Facebook users will be able to share and view 360-degree videos in right from their News Feed. Read more
Samsung is bringing its Ditch the DSLR event to Seattle on October 7th, giving PIX 2015 attendees the opportunity to swap out an old DSLR for a new Samsung NX500. Read more
GoPro has introduced a new entry-level action camera, the HERO+ with Wi-Fi. In terms of specification, this model sits above the HERO, but below the recently launched HERO+ LCD. Read more
With just over a week until PIX 2015, we're taking the opportunity to introduce you to some of our talented re:FRAME speakers. A former features editor at a daily newspaper, Aaron Draper's passion for lighting is evident from his 'Underexposed' photo series. Read more
As part of CreativeLive's annual 'Photo Week', DPReview took part in a panel discussion with other members of the photography industry to discuss technology, photography, and a lot more besides. Read more


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Registration takes less than 1 minute.
Rickmers-Linie, Schneider and U.S. Bank Corporate Payment Systems name chief officers, while NYK Ports and ABP appoint business directors.
The House Energy and Commerce Committee on Thursday approved legislation to lift the nearly 40-year-old ban on crude oil exports, a move it said will boost the U.S. economy.
The home improvement retailer opened a 1.6 million-square-foot direct fulfillment center in Troy Township, Ohio to support continued growth in online sales.
No sighting of lifeboat yet as multiple aircraft and ships search the area for TOTE Maritime Puerto Rico ship and crew.
Rep. Stephen Fincher, R-Tenn., introduced a bill that would restore Ex-Im Bank's operations and include various reforms, but will require a "discharge process" to reach the House floor for a vote.
The company's minority investment in e-commerce specialist Ally Commerce Inc. is more about research than revenues, according to Rimas Kapeskas, head of UPS's strategic enterprise fund.


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Ruth Fry, 92 - March 05, 2008
Ruth E. Fry, 92, of Farnam, died Monday, Feb. 25, 2008, at the Gothenburg Memorial Hospital.
A graveside memorial service was held at the Highland Cemetery at Bertrand on Thursday, Feb. 28, with the Rev. Cathi Braasch of Hope Lutheran Church of Smithfield officiating.
Fry was born on March 4, 1915, at Smithfield, to Wilbur and Canna Waln.
She was preceded in death by: her daughters—Carol (Donald) Freeman and Virginia Lee Wendland; her son, Albert Eugene Wendland.
Survivors include: her husband of 47 years, Larry; a son, Darrell (Barbara) Wendland of Council Bluffs, IA; a daughter, Iona (Rodean) Cornelsen of Johnstown, CO; 14 grandchildren, 21 great-grandchildren, three great-great-grandchildren; many nieces and nephews.
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- Softball team survives slugfest at Cozad


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CBRE is the only commercial real estate services company in the Fortune 500. Be the preeminent, global commercial real estate services and investment firm,...
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We are hiring sales reps that want to substantially increase their income by educating the public about advanced solutions for their retirement funds. You will earn a onetime commission but more importantly build a LARGE residual commission. Our average rep is making over $120,000 of RESIDUAL commission by their 3rd year. You make this commission for little or no extra work.Annua Group has ...
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Sep 8 - Dearborn, MI
Sales Reps: Sell No Credit Check and Business Financing, Six Figures
BizProfit is a business consulting firm specializing in PROFIT BUILDING solutions to businesses. We have an A+ rating with the BBB. We currently have business consultants throughout the US. We represent multiple different revolutionary finance companies.You make upfront commissions and most importantly build a VERY LARGE residual income. This is truly a 6 figure income position. The great ...
Friedman Integrated Real Estate Solutions is one of the Midwest's largest commercial real estate organizations....
Jul 30 - Farmington Hills, MI
McKinley is a national leader in real estate and property management. McKinley specializes in solving complex real estate problems for its own portfolio and...
Jul 29 - Taylor, MI
SALES: We have LEADS and a PROVEN system, No License Required
Timberland Partners is a premier real estate investment and management company that specializes in the acquisition, financing and management of multifamily and...
Sep 4 - Southgate, MI
10-24mm lenses are preferred for real estate photography. CirclePix is the #1 Real Estate Marketing company in the nation....
Jul 22 - Sterling Heights, MI
In-Site Representative
Summary of Position The On Site Representative works directly with the Management Team and Client teams and is responsible for managing client satisfaction while on site in the Client's office. The On Site Representative will act as liaison between the Client, Closing Management Team and Closing Services teams. The On Site Representative is responsible for ensuring that the Client's closing ...
Administrative Assistant - Real Estate
Administrative Assistant position is available with Intrust Properties Team at Keller Williams Realty Rochester/Troy. The qualified candidate I am looking for will play an important role on a rapidly growing real estate team and personally grow as well. · They will provide the support I need to maintain a high level of customer service and play an active role in continuing to grow ...
Sep 30 -
Regional Property Manager
Overview:APM Management, LLC is seeking a qualified candidate to join our Operations team as a Regional Property Manager. Super-organized, highly-motivated, customer-oriented, success-driven creative thinkers NEED apply. As a Regional Property Manager with APM, you will focus on maximizing the profitability of our assets within your defined market area through the creation of creative ...
Sep 29 -
Ann Arbor
Apartment Maintenance Technician
A Cooperative Townhouse Community is looking for a maintenance technician who is able to handle service requests, perform unit renovation and turnover, perform snow removal and other typical maintenance functions. Ideal candidates should have 2 years experience in pluming, electrical, and other typical maintenance functions in an apartment community.
Sep 28 -
Sep 27 -
Ann Arbor
Sep 27 -
Sep 27 -
Experience in recruitment, health clubs, real estate/time shares/apartment leasing, weight loss, hair replacement solutions or similar fields a plus....
Sep 22 - Bingham Farms, MI
Real estate leases and other real estate related matters. JD degree is required, along with five plus years of experience primarily as a Generalist in corporate...
Sep 10 - Ann Arbor, MI
Real Estate Settlement Procedures Act (RESPA); ASPS), is a leading provider of mortgage, financial and technology services for the real estate industry....
Sep 2 - Detroit, MI
ASPS), is a leading provider of mortgage, financial and technology services for the real estate industry. Compliance Agency Specialist....
Aug 31 - Detroit, MI
If you have prior work experience in real estate, that's a big plus. At this role, you will be showing property and closing deals as a real estate sales rep....
Sep 21 - Detroit, MI


text:
US: Beam Inc offloads budget brands to Luxco for US$65m
Beam Inc has agreed to sell a group of its "economy" spirit brands to Luxco for around US$65m.
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ReviewGist App
Read reviews on the go.
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City Hotel Mannheim
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Travel Blogs from Mannheim
Day 11
... cents.....Andy said Germany charges more for everything. We stopped at one servo for a loo break and were amazed at the toilets that were there.....the seat actually rotates and is cleaned before you use it. One of those things you have to see to believe. On we went to Cologne where we saw the Cathedral......an amazing building erected in the 13th century. We also did a little souvenir ...
John Deere factory tour.
... Arrived at Munich main train station a little before 5am & as train already there we embarked. Seats comfortable with power & wifi. Left at 5.27 on time travelling through Augsburg,Ulm,Stuttgart & as we were delayed due to a blockage on the line we diverted via Heidelberg. Arrived in Mannheim just short of 8.55am. Tour was to start at 9am. A very brisk 15 min walk saw us into the John Deere forum. After our ...
Speyer Day 7 - Mannheim
... us directly to our destination. One hiccup in the trip was the stop to re-fill the tank. I filled it an the pump stopped automatically when it was full. I pulled the trigger once more to keep filling and the pump stopped automatically again - filled. We continued to the Hertz office.
All was fine with the car except that the fuel gauge showed 7/8 tank. But I had just filled it. I told Buddy I would go and fill it to make sure so he gave me back the keys and James and ...
Steadying my Resolve
... Mont Blanc which was amazing. Louiselle was very accommodating and eating an authentic Raclette in a Swiss chalet overlooking the valley is something I won"t forget.
Belgium. Steffie and I took the train for a long weekend in Belgium and got around to seeing Brussels, Bruges and Ghent. Having known very little about the country, it was cool to check out the Atomium, Mini Europe and drinking a beer while sitting ...
Heidelberg Castle
Nestled in the hill 300 feet above the city of Heidelberg stands the breath-taking Heidelberg Schloss (castle). The castle is a combination of several buildings surrounding an inner courtyard, put together with a haphazard look. Each building highlights a different period of German architecture.
The castle has a history almost as old as the city itself. The first parts of the castle were constructed around 1300, but it wasn't before Prince Elector Ruprecht III (1398 – ...


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Total Time:
1 hr 15 mins
6 to 8 servings
Any Festival of Lights celebration worth its weight in gelt has latkes. Too often these fried potato pancakes are greasy and one-dimensional, and make the house smell. In this recipe, Sara Dickerman adds turnips and thyme, and fries the latkes in duck fat, for small, flavorful patties that will make any Hanukkah reveler happy. As for the smelly house, turn to these tips.
Game plan: You could serve these with duck confit and use the leftover duck fat for frying. This recipe is fleishig if made with duck fat.
This dish was featured as part of both our Frying Feast menu and our Hanukkah Recipes photo gallery.
A bone-in leg of lamb recipe studded with garlic and basted with duck fat.
A quick hors d'oeuvre or light meal.
Smoky pastrami, horseradish mayonnaise, and pickles top crispy celery root latkes for an impressive appetizer.


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Find Hi Fi Equipment | Quotes Coupons Reviews
Find out more information about Hi-Fi Equipment, including quotes, reviews or special coupon... read moreoffers in dLook's business listings within . Through dLook search you can refine your preferred search area or results further from national down to a local suburb and then you may vary search terms to find results such as pre amplifier, av receivers or sound and more in this category and in the areas that match a product or service type. Use the free quotes facility to seek quotes, read reviews, seek discount coupons or learn more about these businesses, products or services. Or just email or call a business displayed using the listing information to find out more about the Hi-Fi Equipment range of products and services on offer. Premium listings also feature social media information including Facebook pages, Twitter feeds and often a promotional video from YouTube click through to find more.
TCT Electronics - Hi Fi Repairs Yeerongpilly │ Television Repairs Brisbane
TCT Electronics repairs television sets and other electronic devices at affordable prices.
Get high quality repair service for your audio, video, and gaming equipment with TCT Electronics. Call today on 0411 834 991. Hi Fi Repairs Yeerongpilly
From entertainment systems and appliances to computers and mobile phones, TCT Electronics offers reliable workmanship that will enable you to enjoy your electrical equipment for longer.
Television Repairs Brisbane
Do you see intermittent distortion of the volume or pictures on your TV screen? Do you find it difficult switching over the channels or turning the power on and off?
When these problems arise, it is recommended to consult a television repair specialist immediately. TCT Electronics can provide you with an accurate diagnosis of your TV problem and repair it accordingly. Game Console Repairs Morningside
Isn't it annoying when you suddenly cannot continue playing your... See More
Products: Television Repairs, Mobile Phone Repairs, Audio Repairs, Video Camera Repairs, Laptop Repairs, Hi Fi Repairs, Home Appliance Repairs, Electrical Appliance Repairs
Services: West End, Holland Park, Morningside, Moorooka, Greenslopes, Highgate Hill, West End, Salisbury, Sherwood, Graceville, Seventeen Mile Rocks, Holland Park, Mount Gravatt, Chelmer, Carindale, St Lucia
Quality Home Hi Fi Receivers and Cinema Sound at Best Prices
The new Onkyo TX-NR626 and NR525 receivers build upon the previous award winning TX-NR616, adding new features like internet content streaming, Airplay and a Marvell Qdeo processor that can up-scale sources to QFHD and 4K pixel resolution. Team it with an Optoma Projector for a stunning home theatre system.
Onkyo has an enviable reputation for delivering high-end performance at a budget price, and the new TX-NR626 does not disappoint delivering class leading audio sound with the highest quality video up-scaling to ensure the TX-NR626 delivers memorable 3D cinema experiences. The new Onkyo is also packed with eight HDMI inputs (including a front-panel input), brushed metal front panel, built-in networking port, Wi Fi and an extensive array of streaming music services.
The TX-NR626 is one of Onkyo's new breed of receivers that can link directly to the internet... See More
Products: Onkyo TX-NR626 and TX-NR525 Receiver Amplifier
Services: Top value Hi Fi Receivers and Amplifiers for home hifi, video and cinema online Sydney, Brisbane, Melbourne, Canberra, Adelaide, Hobart, Perth, Darwin, Wollongong, Newcastle, Geelong, Ballarat, Bendigo, Shepparton, Albury, Bunbury, Glenelg, Rockhampton, Townsville, Gold Coast, Bathurst, Dubbo, Tamworth, Ipswich, Launceston plus major regional centres, Australia.
Home Comfort Electrical – Electrical Contractor Magill | Adelaide
Home Comfort Electrical Magill is an electrical contractor specializing in rewiring, fault finding, switchboard connection, and other electrical services. Call us today on 0468 993 460.
Electrical Service and Repairs Modbury
Home is where you let your hair down and you can be completely comfortable at home if you have reliable electrical service and repairs available when needed.
And in Adelaide and nearby areas, you can make absolutely sure that you get fast and safe electrical service if you contact Home Comfort Electrical.
This contractor specialises in electricity-related problems or repairs around the home but also handles commercial electrical solutions.
Home Comfort Electrical Magill can also give you lighting ideas guaranteed to satisfy all your lighting needs and preferences.
Ingenuous lighting can do wonders for your property, bringing out that dramatic interplay of lights and shadows to create the ambiance you... See More
Products: Electrical Service and Repairs, Residential Electrician, Appliance Installation, Lighting Solutions, Rewiring, Fault Finding, Switchboards, Emergency Electrician
Services: Magill, Modbury, Burnside, Teringie, Adelaide, Stepney, Maylands, Holden Hill, Windsor Gardens, Rostrevor, Kensington Park, Campbelltown, Glynde, Newtown, Athelstone, Klemzig, Windsor Gardens


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- Based on Outstanding Quality and Compliance -
LEXINGTON, Mass., June 30th /PRNewswire/ -- Instrumentation Laboratory (IL) today announced that it has received the prestigious Supplier Performance Award from Premier, Inc. for a second consecutive year. The award recognizes outstanding performance in quality and compliance by Premier vendors, with less than nine percent chosen as award winners. IL was presented with the honor at Premier's 2008 Annual Breakthrough Conference and Exhibition in Nashville, TN, attended by over 3,000 healthcare professionals.
Premier, based in San Diego, CA, is a healthcare alliance serving more than 2,000 U.S. hospitals and 50,000 other healthcare sites. Premier operates one of the leading healthcare purchasing networks and the nation's most comprehensive repository of hospital clinical and financial information.
"We are very proud to receive this distinction from Premier which is illustrative of our ongoing commitment to and focus on enhancing quality in diagnostic medicine," said Brian Durkin, Director of Sales and National Accounts at IL. "Premier is focused on providing top quality patient care in a cost-effective manner, making IL's GEM Premier 4000 analyzer an ideal tool for their members."
IL and Premier have enjoyed a successful ten-year relationship, with a multi-year contract for IL's critical care portfolio, including the new GEM(R) Premier(TM) 4000 analyzer, the GEM Premier 3000 analyzer, consumables and service.
Serving more than 2,000 U.S. hospitals and nearly 50,000 other
healthcare sites, the Premier healthcare alliance and its members are
transforming healthcare together. Owned by not-for-profit hospitals,
Premier operates one of the leading healthcare purchasing networks and the
nation's most comprehensive repository of hospital clinical and financial
information. A subsidiary operates one of the nation's largest
policy-holder owned, hospital professional liability ri
|SOURCE Instrumentation Laboratory
Copyright©2008 PR Newswire.
All rights reserved


text:
PW6 In-Car Camera System - PatrolWitness
The new PW6 In-Car Video System from PatrolWitness is compact, rugged, and...
Pro-gard Products' Cargo Cabinet is intended for large SUVs and provides officers with additional storage solutions for all of their duty gear. The Cargo Cabinet features slide-out drawers for hanging files or additional storage, large compartments for duty gear, and add-on options including gun racks and hinged polycarbonate lids. The gun rack shelf is lined with Lonseal for easy clean-up, while the cabinet trim is made with black PVC bumper strips.
For more information, click here
Request information about this product


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109 Views 1 Reply Latest reply: Sep 22, 2013 9:00 AM by King_Penguin
King_Penguin Sep 22, 2013 9:00 AM
Re: can i download ibooks on a Mac Pro ? in response to lmcclosk
If you mean the books then yes, but unless they are free or from a publisher such as O'Reilly (who don't put digital rights management on their books) then you won't be able to read them on your Mac.
With OS X Mavericks later in the year that will change, that has an iBooks app for Macs in it : http://www.apple.com/osx/preview/#ibooks


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NORMAN — An opening reception for the "Ramp It Up" exhibit at the Sam Noble Oklahoma Museum of Natural History had to be postponed because of bad weather, but that didn't stop students from the Riverside Indian School from making a field trip to see it.
'Ramp It Up' celebrates Indian skate culture in Norman
The exhibit opened Feb. 8 and will run through June 15. The opening reception was postponed until April 5.
The exhibit celebrates the vibrancy and creativity of the skate culture on American Indian reservations and in Native Hawaiian communities.
"Ramp It Up: Skateboard Culture in Native America" is a new exhibition from the Smithsonian Institution Traveling Exhibition Service, together with the National Museum of the American Indian.
Among the first visitors to the exhibit on opening day were students from the Riverside Indian School in Anadarko who are skateboard enthusiasts.
Skateboarding has been one of the most popular sports on Indian reservations, inspiring and influencing American Indian and Native Hawaiian communities since the 1960s.
Curator Betsy Gordon said Indian skaters and entrepreneurs have combined core lessons learned from the sport such as strength, balance and tenacity with traditional tribal iconography and contemporary art to engage Indian youths in their history and culture.
Continue reading this story on the...


text: Traveling from Arizona to Indiana. Stopped here tonight to sleep. Found a coupon in a coupon book we picked up in Clines Corners, NM. They didn't have any coupon rooms (that is only for Sun - Thurs but didn't say that in the book). The room we got is on the ground floor (thank goodness) and cost $45. Not bad... More


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Alexander McQueen
See it »
News from the inquest.
Although the official hearing of the inquest is set for Thursday, according to an early report from the Times London, Peaches Geldof died of a heroin overdose. They also report that, "Ms. Geldof, 25, had become increasingly obsessed with the death of her mother, Paula Yates, from a heroin overdose in 2000." The inquest follows an initial postmortem, which had inconclusive results. According to the Daily Mail, Kent police could not confirm or deny that the 25-year-old Geldof died of an overdose. A Kent police spokesperson said, "The inquest opens later today and that is all I can say."
Update: CNN reports on Thursday the following statement from Detective Chief Inspector Paul Fotheringham in Kent: "There was recent use of heroin and that the levels identified were likely to have played a role in her death." There is an ongoing police investigation into her death.
It's Harder to Be Thin Than It Was in the '80s
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From Up Close, Raf Simons's Vision for Dior Is Clear
The World's Easiest Way to Highlight Your Face
A Pregnant Supermodel Explains What She Eats
Michelle Obama: No Boy Is Cute Enough to Keep You From Getting an Education
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Selfie Sorority Uses Media Frenzy for Good Cause
Guess Who Renovated This Grand Upper West Side Penthouse
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Take that, sportscasters.A Comprehensive Taxonomy of Men With Long Hair
And why we like them anyway.Teens Are Dying From Train-Track Photo Shoots
The popular photo destination is actually super-dangerous.'Truly Ugly Guy With Glasses' Is Europe's Most Virile Man
Ed Houben has fathered 106 children — that he knows of.The Internet of Parents Is Miserable and I Love It
Why it's so hard to look away.Did the 'Maxipad Bandit' Really Think He'd Escape?
Not so fast, mister.Woman Driven From Her Home by Death Threats After Starting Pro-Choice Hashtag
The hashtag drew intense scorn from anti-abortion activists.Ice-Cold Teens Don't Hesitate to Block Their Exes
"I'm just like this is irrelevant now."Let Sorority Girls Instagram Themselves in Peace
Come on, man.
Whether you're Lena Dunham or an emerging writer, the format has an appealing intimacy.The Bennifer Years Affected Matt Damon More Than Anyone Else
It's just really hard when your buddy breaks up with J.Lo, you know?Someone Used Gasoline to Set a Los Angeles–Area Planned Parenthood on Fire
Police believe gasoline was used as an accelerant to burn down the Thousand Oaks facility.Michelle Obama: No Boy Is Cute Enough to Keep You From Getting an Education
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You have a choice, people.New 'Yelp for People' Will Let You Rate Everyone You Know
Kind of like Lulu, or Hot or Not, or ...Ruth Bader Ginsburg Is Glad She Was Trained in the '60s
She's glad she was trained in the Mad Men era.Lena Dunham Apologizes for Joking About Abuse
"When I heard my own quote I was like, 'Jesus, Lena, no.'"Desperate Republicans Attack Planned Parenthood Chief's Salary
"The disrespect, the misogyny rampant here today tells us what is really going on."Blake Lively's Lifestyle Is No Longer for Sale
She will Goop no more.


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Respond to Review of R. Thomas Deluxe Grill
by 441dave
Review: Though not 100% vegetarian, R Thomas has plenty of vegetarian and vegan options. The bowls are our favorite, as well as the flax-seed "pate". The seating area is all patio, but has space heaters and zip-up sides for when it gets cold. One time they let us bring our dogs, the next time they didn't. I guess the policy depends on who's enforcing it. They have vegan desserts, but they aren't the greatest.
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text:
DiscardedYKTTW Pragmatic Heroism YKTTW Discussion
|Pragmatic Heroism
Doing good deeds because it helps your long-term goals.
Up for Grabs. Sometimes people do good things because it makes them feel good about themselves. Others do good just because it's what they do. Not those who follow this trope. If one of them stops by to help, you can be sure it fits into some larger plan, and that they'll expect you to return the favor at some point, either willingly or unwillingly. If you're lucky, that larger plan will have something to do with Saving the World instead of just benefiting the "hero" themselves. This trope is the calling card of a Guile Hero, and some aspects of The Paragon also fit under this. Compare and contrast Pragmatic Villainy, which is about refraining from evil acts because it interferes with the character's larger goals.
Replies: 3


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ClassicsOnline Home » HAYDN, J.: String Quartets, Op. 2 and Op. 20, No. 1 (arr. F. de Fossa as Grand Duos for 2 guitars) (Duo Sonare)
ClassicsOnline customers will not be able to use their log in to access the new HD site. Please create a new ClassicsOnline HD•LL account to download albums, subscribe to streaming, create playlists and more!


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If you live in Ann Arbor, you've probably seen the Robot Store. It's a little shopfront on Liberty, just around the corner from Literati, and it's got big windows full of silvery robots beckoning passersby inside, promising robot supplies, robot repair services, and tutoring, of all things. Come inside, and you see not only robots, but reading and writing humans, aged 6-18, as well as older humans, writing tutors, volunteers, and staff. Continue reading "Meet a Community Member: Frances Martin of 826michigan"
Fresh this Weekend, Like a Bag of Donuts from the Cider Mill Enjoyed Beside the River, but Without the Bees
A few new books blew into our store this week: Robert Reich's latest, The Heart Goes Last from the ever-prolific Margaret Atwood, and an irresistible trocito (and opportunity to join Patti Smith in a chorus of "Hail César!") from the brilliant César Aira. Dang, New Directions, never stop giving us the finest book covers in the land. Too dang fine. Continue reading "Fresh this Weekend, Like a Bag of Donuts from the Cider Mill Enjoyed Beside the River, but Without the Bees"
Gourd Season Reading
The blood moon has entertained us, the leaves begun their burnishing, and ahoy there, is that sweatered hunk strolling the windy boulevard Autumn Man? (Or local author and sweetie of the bookstore Chris McCormick?) How's your gourd? Are you filling it with knowledge? Or simply soups and gourd-flavored lattes? Is Midterm ennui upon you? Do your fingers itch to knit a sweater in three hues of goldenrod, but find themselves hopelessly tangled? We got you. Do you wish to make jam, but fear poisoning all dear to you with botulism? We got you. Continue reading "Gourd Season Reading"
Meet a Bookseller: Jeanne!
Get to know our Queen. Her name is Jeanne.
1.) What do you do at Literati?
I'm the manager at Literati and I love my job. I needn't have worried that there wouldn't be "life after Borders." Specifically, I do backlist ordering (my favorite task except for fussing with books), staff scheduling, and payroll. What I love doing at the store is: talking and learning about books with the staff and customers; doing displays (especially tables)–trying to find the right juxtaposition of books to highlight and draw attention to beautiful book covers and trying to find a mixture of books on a table that will have something to appeal to almost everyone who comes in (I call this "fussing" or alternatively "playing" with books); writing a review of a book I loved and want to share with others, though I agonize over my reviews excessively; poking around at Treasure Mart for things that will improve the store (a "new" typewriter, a bench to facilitate browsing, to name a few recent finds); but I suppose what I like most about my job is working with Mike and Hilary and the amazing staff they hired and continue to hire—that's the best part, hands down. Continue reading "Meet a Bookseller: Jeanne!"
Getting Real (A Little Too Real?) With Coloring Books Intended For Adults
If you've visited our bookstore lately–or any bookstore for that matter–you've probably noticed that we are carrying a ton of coloring books intended for grown-up people. Paisley prints, urban scenes, weird animals, intricate mandalas–we've got it all displayed on two of our three floors. It's possible you've read about the persistent publishing trends underlying the presence of adult coloring books in bookshops across the nation, and about the psychological studies in support of the mental health and wellness benefits that might be attributed to the activity of coloring inside the lines. And perhaps you've read the snarkier skeptics of the trend also. (To which I sorta shrug and go, "Don't tell me what to do; I'm grown.") Continue reading "Getting Real (A Little Too Real?) With Coloring Books Intended For Adults"
New in the Shop this Weekend (September 18th–20th)
So much reading to do this weekend! We are delighted that our very first Literati Cultura pick, Lauren Groff's Fates and Furies, has arrived in the shop. Many of our booksellers had the chance to get a sneak peak at an advance of this book, and absolutely loved it. Here's a great write-up in the Sunday NY Times Book Review. (And if you haven't joined Literati Cultura yet, here's everything you need to know in order to receive beautiful signed first edition books, lovingly handpicked by Literati booksellers, along with a piece of word art letterpressed by local dynamos Wolverine Press every month.) Continue reading "New in the Shop this Weekend (September 18th–20th)"
Man Booker Shortlist
The Man Booker Prize Shortlist was announced this week, and we're lucky to carry all of the wonderful titles but one (Sunjeev Sahota's book, The Year of the Runaways, which won't be available to US bookstores until March of 2016.) Continue reading "Man Booker Shortlist"