text:
|Home | About | Journals | Submit | Contact Us | Français
Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted—only one allele is active, depending on parental origin—and this pattern of expression is maintained epigenetically in almost all tissues. IGF2 activity is further controlled through differential expression of receptors and IGF-binding proteins (IGFBPs) that determine protein availability. This complex and multifaceted regulation emphasizes the importance of accurate IGF2 expression and activity. This review will examine the regulation of the IGF2 gene and what it has revealed about the phenomenon of imprinting, which is frequently disrupted in cancer. IGF2 protein function will be discussed, along with diseases that involve IGF2 overexpression. Roles for IGF2 in sonic hedgehog (Shh) signaling and angiogenesis will also be explored.
In the early 1900s, the innovative surgeon Alexis Carrel experimented with maintaining tissues and whole organs in vitro, hoping to advance techniques in organ transplantation. Carrel observed that certain tissue extracts could induce cell proliferation, and he published his findings with this disclaimer:
"Possibly the finding of the activating power of tissue extracts will have no immediate practical application. Nevertheless, it may be indirectly useful by leading to the discovery of some of the factors determining the growth of tissues and of the unknown laws of cell dynamics… [1]."
Carrel was mistaken that this finding would have no practical application—rather, it pioneered the discipline of tissue culture and the widespread use of serum to support in vitro cell growth. He was right, however, that this "activating power" would eventually lead to the discovery of growth factors, many of which were isolated and characterized in the decades that followed. Two of these factors, which were structurally similar to insulin, had many effects on cell growth and differentiation. In 1987, after 30 years of confusing nomenclature, these proteins were designated as insulin-like growth factor I (IGF1) and insulin-like growth factor II (IGF2) (Table 1).
The IGFs regulate cell growth and differentiation in many species. The anabolic functions of growth hormone are largely mediated by IGF1, which designates IGF1 as a major determinant of somatic growth [10]. Rare mutations in the human IGF1 gene lead to severe growth inhibition and mental retardation [11]. Igf1-null mice are born at 60% of normal birth weight, and the few that survive to adulthood are less than one-third the size of normal mice [12, 13]. On the other hand, IGF2 is virtually dispensable for post-natal development in mice, since Igf2 expression is almost entirely limited to the embryo in rodents [14]. At birth, Igf2-null mice are also growth-impaired but are otherwise normal, and subsequent growth proceeds at normal rates [13].
These studies support a somewhat redundant role for IGF2; furthermore, its designation as the "second" IGF seems to have relegated it to a lesser role than IGF1. However, IGF2 is the predominant IGF in adult humans (reviewed in [15]), and inappropriate IGF2 expression is implicated in a growing number of diseases (reviewed in [16]). The importance of IGF2 is highlighted by its complex and multifaceted regulation. The gene that codes for IGF2 is imprinted such that only one allele is expressed, depending on parental origin [14]. Besides the intriguing mechanisms that surround its imprinted expression, IGF2 is further modulated by a concert of differentially expressed proteins and receptors that determine IGF availability (reviewed in [17]). This review will examine the complex epigenetic regulation of the IGF2 gene and provide a broad introduction to IGF2 signaling. The ability of IGF2 to stimulate cell proliferation and differentiation will be reviewed, which will lead to a discussion on its involvement in various cancers and other diseases. The angiogenic functions of IGF2 will be addressed, and conclude with a proposal that IGF2 is a key mediator facilitating the angiogenic activity of sonic hedgehog (Shh).
Igf2 is widely expressed during murine embryonic development and is particularly important in placental growth [18]. As with many genes that regulate placental development, Igf2 is imprinted, or expressed monoallelically, and active only on the paternally inherited allele. Igf2 is highly expressed in the mouse embryo, but levels decline dramatically after birth; in adult mice, Igf2 transcripts are detectable only in the choroid plexus and leptomeninges, where expression is biallelic [14]. IGF2 is also imprinted in humans, but is expressed biallelically in the choroid plexus, leptomeninges, and perhaps the developing retina [19]. However, human IGF2 is also expressed in the adult, with transcripts arising from an adult-specific promoter [20]. The corresponding region in the mouse Igf2 gene contains two pseudoexons and what appears to be a remnant of this adult-specific promoter—which may explain why Igf2 expression ceases after birth in mice but not in humans [21].
Almost all known imprinted genes occur in clusters with one or more reciprocally imprinted genes (reviewed in [22]). The mouse Igf2 gene lies on the distal region of chromosome 7 with the oppositely imprinted, non-coding gene H19. Igf2 and H19 share a set of enhancers that act on either gene, depending on parental origin. In eukaryotic DNA, promoters generally harbor regions dense with CpG dinucleotides, which are targets of methylation. These "CpG islands" are often methylated in inactive promoters. On the paternal chromosome, the H19 promoter region is methylated and inactive; this methylation and expression pattern is passed on when cells divide. Because this inheritance of gene expression patterns is achieved without altering the DNA sequence, it is called epigenetic.
The Igf2 promoter is not methylated on the maternal chromosome, so another mechanism must account for silencing Igf2. Several kilobases (kb) upstream of the H19 promoter is a differentially methylated region (DMR) that, when deleted, reactivates Igf2 on the maternal chromosome [23]. This region, also called the imprinting control region (ICR), was found to harbor binding sites for CCCTC binding factor (CTCF), an insulator protein that demarcates active and inactive chromatin domains (reviewed in [24]). Methylation of the CG-rich CTCF binding sequence prevents CTCF binding. Thus, on the paternal chromosome, the DMR/ICR is methylated, CTCF is excluded, and the enhancers act on the Igf2 promoter. Conversely, on the maternal chromosome, CTCF forms a chromatin insulator that blocks the enhancers from activating Igf2 (Figure 1A).
Murine Igf2 was the first gene found to be imprinted, and has served as a model of allele-specific gene repression—the most extreme example being X chromosome inactivation, where one X is silenced in each somatic cell of XX female mammals to equalize gene dosage with XY males [29]. Igf2 imprinting and X chromosome inactivation are the most well-studied mechanisms of epigenetic regulation, and the parallels between these mechanisms give insight into the epigenetic alterations that are abundant in cancer.
X chromosome inactivation generally occurs in a random fashion and silences either X; however, in some mammals and in certain tissues of others, the paternal X is always silenced. In either random or imprinted X chromosome inactivation, the X that is destined to be silenced expresses the non-coding Xist RNA, which covers the chromosome and mediates silencing (reviewed in [30]).
Xist lies in a region called the X inactivation center (XIC) along with another noncoding gene, Tsix, is transcribed antisense to Xist and expressed on the active X chromosome [31]. Not long after CTCF was shown to regulate imprinting at the Igf2/H19 locus, a similar mechanism was found at the Xist/Tsix locus. In a region implicated in controlling both random and imprinted X chromosome inactivation, functional methylation-sensitive CTCF binding sites were identified (Figure 1B). This region was later found to contain developmentally specific enhancers [28] and to be differentially methylated in vivo [27]. CTCF has since been demonstrated to control imprinting at several other gene domains, and putative binding sites have been discovered in several other imprinted loci [32]. However, not all imprinted genes contain functional CTCF binding sites. It is proposed that another multifunctional transcription factor, yin yang 1 (YY1), functions as a methylation-sensitive insulator that mediates allele-specific gene activation or silencing at some loci. YY1 has been found to control imprinting at the human SNURF-SNRPN locus within the Prader-Willi syndrome and Angelman syndrome locus, and the PEG3, Gnas, and Nespas genes ([33] and references therein). Interestingly, it was shown recently that YY1 is a cofactor for CTCF in X chromosome inactivation [34]. Because both CTCF and YY1 are ubiquitously expressed, it is possible that tissue- and developmentally-specific imprinting of Igf2 is accomplished through a combination of these factors.
The similarities between Igf2/H19 and Xist/Tsix regulation have additional implications for other regulatory mechanisms that may be aberrant in cancer. The X chromosomes initiate silencing after forming a transient interchromosomal complex (reviewed in [30]). This pairing phenomenon has also been observed with the Igf2/H19 region, in which CTCF mediates interchromosomal colocalization and induces trans effects on a non-homologous chromosome [35]. Interchromosomal pairing may increase the frequency of mitotic recombination, which can account for both heritable and sporadic mutations [36]. Because CTCF mediates interchromosomal pairing of the IGF2/H19 region, it may very well facilitate such mitotic recombination events. X chromosome inactivation has also drawn attention in the field of cancer research with the recent discovery of X-linked tumor suppressor genes; when mutated, these can lead to hemizygosity in males and skewed X inactivation in females (reviewed in [37]). One gene, FOXP3, codes for a forkhead family transcription factor that represses the HER-2/ErbB2 oncogene [38]. Interestingly, the forkhead transcription factors are targets of the PI3-kinase pathway, which is activated by IGF signaling (reviewed in [39]). The other X-linked tumor suppressor, WTX, was frequently inactivated in Wilms' tumor, a disease also associated with disrupted IGF2 imprinting [40].
X chromosome inactivation can have other implications for Igf2/H19 regulation as well. There is mounting evidence that non-coding (especially antisense) RNAs regulate allele-specific gene expression (reviewed in [30]). Multiple sense and antisense transcripts have been detected in the mouse Igf2 5' region, and the major antisense transcript, Igf2AS, is paternally expressed and noncoding [41]. An antisense message transcribed from a homologous region near human IGF2 encodes a putative 273-amino acid protein of unknown function [42]. It remains unclear whether IGFAS regulates IGF2 or H19 imprinting; nonetheless, it may have biological importance. In Wilms' tumor, IGF2AS is highly expressed and demonstrates sporadic loss of imprinting [42, 43]. As stated before, disrupted IGF2 imprinting is implicated in a number of diseases, and can be attributed to increased gene dosage and subsequent increases in IGF2 signaling, which will be discussed in the following section.
The IGFs signal primarily through the type I IGF receptor (IGF1R), but there is significant crosstalk between the IGF and insulin systems as certain variants of the insulin receptor (IR) have been shown to bind IGFs (Figure 2). The alternatively spliced IR-A isoform, which is expressed predominantly during embryogenesis [44], binds insulin and IGF2 (but not IGF1) with high affinity [45]. IGF2 can also stimulate insulin-like metabolic responses by binding the classical IR-B isoform; furthermore, functional heterodimers can form between IGF1R and the IR isoforms (reviewed in [46]). Thus, tissue-specific effects of insulin and the IGFs may be accomplished through differential expression of the receptors and receptor hybrids. Though IGF1R is activated more efficiently by IGF1 [47], the ability to signal through IR potentially gives IGF2 a broader range of biological functions than IGF1.
IGF2 has high affinity for another receptor, IGF2R, and is its principal ligand (Figure 2). However, IGF2R does not transduce a signal; rather, it serves mainly to limit IGF2 bioavailability by targeting IGF2 for degradation (reviewed in [48]). Interestingly, the IGF2R gene is also imprinted—but it is maternally expressed (reviewed in [16]).
Whereas insulin circulates freely in the bloodstream, the IGFs are found in complexes with the IGF binding proteins (IGFBPs). Six different IGFBPs have been identified, and each binds the IGFs with significantly higher affinity than IGF1R. The expression patterns of the various IGFBPs differ both spatially and temporally, and they have distinct activities (Table 2). Thus, IGFBPs are important modulators of IGF action, availability, and tissue distribution (reviewed in [17]). Differential expression of IGFBPs, as well as differential expression of IGF receptors and receptor hybrids, may govern the cell- and tissue-specific actions of IGFs.
IGF1 and IGF2 are well known for their mitogenic activities. Almost all cell types express IGF1R, so the IGFs can stimulate growth and differentiation in many tissues (reviewed in [49]). Upon binding to IGF1R, the IGFs trigger the receptor tyrosine kinase activity, which leads to phosphorylation of itself and its major substrate, the insulin receptor substrate 1 (IRS-1). Phosphorylated IRS-1 can activate the Ras/Raf/MAPK and PI3-kinase/Akt cascades, and depending on the cell type, stimulate proliferation, differentiation, or both (reviewed in [50]). PI3-kinase activation can lead to anti-apoptotic signals, and components of this pathway are frequently amplified or mutated in cancers (reviewed in [51]).
The role of IGF2 in muscle development has been studied extensively. IGF2 is upregulated early in MyoD-induced in myocyte differentiation, and signals in an autocrine loop to activate PI3-kinase and Akt [52]. IGF2 inhibition leads to reduced expression of MyoD target genes, which suggests that IGF2 is essential for amplifying and maintaining MyoD efficacy [53]. IGF2 is also essential in bone development, where it promotes proliferation and differentiation of bone cells. Down-regulation of IGF2 most likely accounts for the decrease in bone mass observed with cortisol use [54]. Thus, IGF2 has great therapeutic potential in wound and fracture healing.
Growth in the developing mouse embryo is largely governed by IGF2. When a targeted Igf2 deletion is transmitted paternally, mouse embryos inherit only the inactive maternal allele and are born runted [14]. Conversely, IGF2 overexpression, achieved by disrupting the inhibitory Igf2r [55], by deleting H19 [56], or by transactivating Igf2 [57], leads to fetal overgrowth and malformations with characteristics that resemble Beckwith-Wiedemann syndrome (BWS, discussed below).
IGF2 is regulated precisely to ensure monoallelic expression in most tissues [19], which emphasizes the importance of gene dosage. Normal development requires accurate expression, and many disorders can be attributed to an abnormally high dose of IGF2 caused by loss of imprinting (LOI). BWS is one such disease, characterized by fetal and neonatal overgrowth, and is often accompanied by an increased risk of childhood cancers (reviewed in [58]). BWS patients almost always have mutations in the chromosome 11p15.5 region, a large cluster of imprinted genes that includes IGF2 and p57KIP2 (Figure 3). Most of these mutations affect imprinting; quite often, biallelic IGF2 expression and H19 methylation are observed (reviewed in [16]). BWS usually occurs sporadically, but in rare familial cases IGF2 LOI may be caused by deletions of the CTCF binding sites in the maternal IGF2/H19 ICR [59, 60].
Disrupted imprinting is perhaps the most common observation in cancer (reviewed in [61]), and IGF2 overexpression is a recurring theme. Wilms' tumor, a childhood cancer of the kidney, is often associated with defects in the WT1 gene, which encodes a transcriptional repressor of IGF2 [62]. Wilms' tumor is also associated with mutations in the 11p15.5 region that affect IGF2 imprinting: altered IGF2 expression accounts for nearly 50% of all cases of Wilms' tumor, and IGF2 LOI is found in the vast majority (90%) of pathological cases [63]. IGF2 LOI has also been observed in many other cancers. Both benign and malignant breast lesions show biallelic IGF2 expression, and altered imprinting of IGF2 is has been identified in hepatoblastoma, lung cancer, cervical carcinoma, rhabdomyosarcoma, choriocarcinoma, and testicular cancer ([64] and references therein).
The epigenetic mutations associated with cancer, such as aberrant methylation or LOI, may magnify the effects of genetic mutations or even have causal roles. In either case, epigenetic changes have potential value for assessing disease risk and prognosis. In a mouse model of intestinal cancer, where the adenomatous polyposis coli (Apc) gene is mutated, supplementary Igf2 LOI increases the incidence of intestinal hyperplasia. The clinical relevance of this is corroborated by the fact that patients with IGF2 LOI also have an increased risk of developing colorectal cancer [65]. Alterations involving CTCF may also be informative. Elevated CTCF expression levels have been reported in breast cancer, where it is postulated to have anti-apoptotic actions [66]. Gene activation by a CTCF homolog is observed in lung cancer [67, 68], and methylation changes in CTCF binding sites have also been reported in osteosarcoma [69]. Because epigenetic changes such as LOI and demethylation are among the earliest evens in cancer progression (reviewed in [70]), assays for epigenetic biomarkers may allow for early detection, prevention, and treatment of cancer.
Igf2 overexpression sometimes occurs without apparent LOI or gene duplication. Other factors, such as sonic hedgehog (Shh), can also transcriptionally activate Igf2. Shh is a developmental morphogen involved with patterning and organ specification, and its signaling pathway is mutated in several diseases (reviewed in [71]). The Shh cascade culminates in the activation of Gli, a transcription factor that induces several target genes (Figure 4).
Shh has been demonstrated to upregulate Igf2 both in vitro and in vivo. When mouse mesenchymal cells are treated with Shh or transfected with Gli1, Igf2 mRNA is upregulated [72]. A Ptc-deficient mutation in mice, which results in constitutive Gli activation, increases IGF2 protein levels and also the formation of medulloblastomas and rhabdomyosarcomas [73]. It is not entirely clear how Shh induces Igf2 expression. Though putative Gli-binding sites have been identified in the mouse Igf2 promoter [72], it is not known whether these sites are functional, or if they exist in the human VEGF promoter. However, functional Gli sites have been documented in the human IGFBP-6 promoter [74]. IGFBP-6 specifically binds IGF2 and is generally thought to have anti-proliferative properties. Nonetheless, like most of the IGFBPs (Table 2), IGFBP-6 can have contrasting activities, and has also been shown to be anti-apoptotic and tumorigenic (reviewed in [75]).
IGF2 itself may provide an oncogenic signal in some systems, such as the mouse mammary gland, where transgenic Igf2 overexpression induces adenocarcinomas [76]. In mouse models of rhabdomyosarcoma and medulloblastoma, Igf2 alone is insufficient to generate tumors; however, it can enhance the tumorigenic potential of Shh [73, 77]. Interestingly, tumors often overexpress the IR-A variant, which binds IGF2 with high affinity; thus, concomitant IGF2 and IR-A overexpression can potentially generate an autoproliferative loop [30]. Taken together, these observations substantiate the hypothesis that IGF2 can supply the "second hit" necessary for oncogene-induced tumors [78].
Angiogenesis, or blood vessel growth, is another critical element of tumor progression that may involve IGF2. Oxygen, nutrients, and metabolic wastes can simply diffuse in and out of small tumors, but growth beyond a critical size (1 mm3) requires a vascular network (reviewed in [79]). Areas of hypoxia within tumors induce the expression of angiogenic factors, which prompt an influx of vessels from surrounding tissues. Neovascularization also facilitates the spread of cancer cells to other tissues; thus, there is a correlation between high metastatic potential and tumor vascularity (reviewed in [80]).
Vascular endothelial growth factor (VEGF) has a central function in both normal and pathological neovascularization, and its expression is upregulated in tumors (reviewed in [81]). Hypoxia-inducible factors (HIFs) are principle mediators of VEGF upregulation, though VEGF mRNA levels are also increased via message stabilization [82]. Transcriptional regulation also occurs through other cis elements in the VEGF promoter, and can be instigated by various growth factors, hormones, and oncogenes (reviewed in [83]).
Though studies of the IGFs in vascular development are limited, IGF2 may participate in angiogenesis through its ability to upregulate VEGF. In hepatocellular carcinomas cells, hypoxia-induced VEGF expression is increased by IGF2, which is itself upregulated by HIFs [84]. Other studies have suggested that IGF2 signaling upregulates VEGF in part by increasing HIF levels [85, 86]. Because reciprocal upregulation of IGF2 and HIF has been demonstrated [87], they may act in synergy to induce VEGF expression. Though the mechanisms remain unclear, the ability to induce VEGF accentuates the importance of IGF2 in tumor development.
IGF2 may also be involved in the pathological neovascularization that characterizes proliferative diabetic retinopathy (PDR) and retinopathy of prematurity (ROP). Several studies have implicated IGF1 in retinopathy (reviewed in [88]), but IGF2 has been largely overlooked—despite reports of 10- to 30-fold more IGF2 in the vitreous of diabetic patients than IGF1 ([89] and references therein). A recent study showed that IGFBP-3 suppressed retinal neovascularization irrespective of IGF1 levels [90], which supported the long-standing notion that IGFBPs can act independently of IGF signaling through IGF1R (reviewed in [75]). However, the potential contribution of IGF2 needs to be examined—specifically, its interactions with other receptors (such as IR-A variant) and whether these interactions are subject to IGFBP regulation. Clearly, the likely role of IGF2 in retinopathy calls for further exploration.
In recent years, Shh has been identified as an angiogenic factor. Studies in zebrafish reveal vascular defects in Shh-mutant embryos [91, 92], and place Shh upstream of VEGF signaling during arterial differentiation [93]. The cascades induced by Shh also appear to regulate vessel formation in mammals. In the mouse embryo, indian hedgehog (Ihh), a Shh homolog, has been suggested to be critical for early vasculogenesis [94, 95]. In Shh-deficient mice, the developing lung is poorly vascularized [96]; conversely, Shh overexpression in the neural tube results in hypervascularization [97]. Shh can also induce angiogenic factors (including VEGF) and promote neovascularization in adult mice [98]. Thus, vessel formation may depend on the ability of Shh to induce VEGF. Though the exact mechanism remains elusive, it may very well involve IGF2, which is a downstream target of the Shh cascade [72] and has a demonstrated ability to synergize with Shh [73, 77]. Moreover, IGF2 has also been shown to induce VEGF [84–86]. Thus, IGF2 may mediate the angiogenic effects of Shh, and provide the critical link between Shh and VEGF.
Though interest in IGF2 has been somewhat skewed towards the study of gene regulation and imprinting, it is likely to attract attention from other fields as studies implicate IGF2 in an increasing number of diseases. The complexity of IGF2 regulation indicates that overexpression can occur at multiple levels. Since IGF2 is pivotal in many developmental and pathological processes, its multifaceted regulation presents a number of potential therapeutic targets.
Because imprinting defects are now recognized as common in the pathogenesis of cancer, the mechanisms surrounding IGF2 imprinting are likely to gain interest as well. Perhaps the most thoroughly studied of known imprinted genes, IGF2 has yielded valuable insight into other epigenetic gene regulatory mechanisms—namely X chromosome inactivation, which also gained significance with the discovery of X-linked tumor suppressors (reviewed in [37]). These studies highlight the multifactorial nature of cancer, in which IGF2 may have a pivotal role. More importantly, they suggest that imprinting and X inactivation are not just interesting epigenetic phenomena, but have considerable functional relevance.
Wendy Chao recently received her Ph.D. in genetics from Harvard Medical School, where her research focused on gene regulation and epigenetics. Her interests in community education have led to credits on ABC News, The Learning Channel, and in U.S. Department of Justice publications. She has been involved in science mentoring partnerships with local schools, and is on the board of advisors of the Foundation for Art and Healing in Boston, Massachusetts. Wendy is also a freelance science writer and Contributing Editor of The Scientist magazine.
Patricia D'Amore received her Ph.D. in Biology from Boston University in 1977. She was a postdoctoral fellow at Johns Hopkins Medical School before moving to the Children's Hospital in Boston where she is currently a Research Associate in Surgery. In 1998, she became Professor of Ophthalmology (Pathology) at Harvard Medical School and a Senior Scientist at the Schepens Eye Research Institute. She is the recipient of numerous awards including the Jules & Doris Stein Research to Prevent Blindness, Senior Scientific Investigator Award, Cogan Award, and the A. Clifford Barger Excellence in Mentoring Award. She is currently the Associate Director of Research and the Ankeny Scholar of Retinal Molecular Biology at Schepens. Dr. D'Amore's research focuses on understanding the mechanism of vascular growth and development. She is the author of 112 publications.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Wendy Chao, Schepens Eye Research Institute 20 Staniford Street, Boston, MA 02114, TEL: 617.912.2558, FAX: 617.912.0128, Email: firstname.lastname@example.com.
Patricia A. D'Amore, Departments of Pathology and Ophthalmology, Harvard Medical School Schepens Eye Research Institute 20 Staniford Street Boston, MA 02114, TEL: 617.912.2559, FAX: 617.912.0128. Email: email@example.com.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
Nice to meet you here at Audiko, where you may search for hot ringtones for your phone. Today we have a ringtone of "...stupendo" by Vasco Rossi as well as 1085 other ringtones by Vasco Rossi. "...stupendo" is a real hit from the "Tracks" album that was issued by Vasco Rossi at their major label together with other 23 tracks. You can listen to all 6 Vasco Rossi – "...stupendo" ringtone variations available here and download it for free right to your smart phone. You can also get other 31 albums produced by Vasco Rossi for all time. "...stupendo" is referred to Italian, and we bring you a huge amount of Italian ringtones absolutely for free. And finally, we have collected lyrics for this track and you can view it here as well. So feel free to browse, listen, download ringtones at Audiko.net. Make your phone sound cool!
Vasco Rossi ...stupendo Ringtone
Similar Ringtones
Browse Genres
Cantautori Italia Italian Italian Pop Italian Rock Italiana Italiano Pop Rock vasco
Albums by Vasco Rossi
Vasco Rossi
Top ringtones by Vasco Rossi
New ringtones
- BC - Outa-Luda-BC
- Brknyo - Platanag-guitrif.1s 2 - 27:09:2014 19.30
- Unknown - Keen V - Un monde meilleur
- Maria - Elena Kyriakou - Take me to church
- gerri halliwell - mi chico latino
- Unknown - ketu love
- sanctuary instrumental - sanctuary instrumental
- D12/Eminem - Eminem - Till I Collapse
- Breaking Bad - Breaking bad remix
- Conor - royalty

subset: commoncrawl


text:
Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
Choice Of Chicken, Beef, Pork Or Tofu Add $4. For Shrimp.
Hand Rolls
Entrees Served With Soup & Salad.
Entrees Served With Rice & Salad.
Served With Soup & Salad
Sushi With Rice. A La Carte By Piece. (No Rice)


text:
The Aviation
Posted 29 August 2014 - 07:06 PM
Posted 29 August 2014 - 07:31 PM
What Violette do you have on order? I must say aviations can be pretty nice! My current favorite gin for aviations is Magellan.
Posted 30 August 2014 - 12:17 AM
Having noted that little is needed for each cocktail I decided against a full bottle at this stage.
Posted 30 August 2014 - 04:33 AM
Massive improvement in the bottle design, too.
- DianaB likes this
The Dead Parrot
Built from the ground up by bartenders, for everyone:
Cocktails, Craft Beers, English Wines in provincial Sussex
Posted 03 September 2014 - 04:49 AM
I have a question in respect of cherry making but I will post it on the Making Maraschino topic in attempt to respect the various threads.
Posted 03 September 2014 - 08:35 AM
I recommend you forgo the cherry rather than use neon. Except maybe for Tiki garnishes, which are intentionally tacky.
- Hassouni likes this
Posted 04 September 2014 - 02:01 PM
I recommend you forgo the cherry rather than use neon. Except maybe for Tiki garnishes, which are intentionally tacky.
I would concur. I don't typically garnish an Aviation anyway and I don't remember that it is routinely called for.
Some people are like a Slinky. They are not really good for anything, but you still can't help but smile when you shove them down the stairs...
Posted 04 September 2014 - 02:40 PM
The Luxardo Maraschino and the Liqueur à la Violette have arrived. I tried to order Luxardo cherries but it seems these are out of stock everywhere (or ridiculously expensive) just now. Having read the topic on making Maraschino cherries we'll have a go at that for the longer term. Too impatient for a first attempt at this cocktail we will enjoy it with a factory red cherry.
There may also be a happy medium between the syrupy dyed abominations, and the hassle/expense of imported or homemade cherries. My local grocer carries these cherries with no artificial additives. I think they're great. Good in an Aviation (though I agree, not necessarily essential), outtasite in a Left Hand.
I wouldn't try to talk you out of making your own if you're up for it, but wanted to let you know of another possible option.
Edited by Craig E, 04 September 2014 - 02:44 PM.
Posted 10 July 2015 - 06:55 PM
It had been a while, so I made an aviation:
2 oz Malacca
1 oz lemon juice
2 teaspoons maraschino
1 teaspoon liqueur de violettes (Tempus Fugit)
To the best of my memory I'd never tried Malacca in an aviation previously. Not bad, and it makes for a pretty color. I have the feeling though, if sampled side by side, I might go with Magellan over Malacca.


text:
C.O.F.F.I.E. Message Board › Restaurant for sale in Downtown Atlata near the new Ferris wheel !!!
|Robin D. D.
user 10903293
Atlanta, GA
The last available restaurant space near centennial park,the new ferris wheel,the football hall of fame,the tabernacle,GSU,Coca Cola museum and many other attractions.The owner is asking $125 financed of $65k cash.The expenses for this space,ie,rent,power,water,gas,trash,security surveillance,ect..can be met for under $4k per month.Can be operated 24 hours per day 7 days a week if you want to do so.The person or persons that control this lease for the next few months or years will become very wealthy.A major player,ie,Dominos,Chic Filet',Starbucks,ect..may want this space as well and they will have to pay you a huge lump sum to get out.You really want to be here when that happens.serious inquirers only please.Robin 404-399-4796...
Meetup members, Log in
By clicking "Sign up" or "Sign up using Facebook", you confirm that you accept our Terms of Service & Privacy Policy


text:
Days Inn Devils River Tx
1312 N SERVICE RD, Sonora, TX 76950
#3 of 5 hotels in Sonora
TripAdvisor Traveler Rating
Based on 66 reviews
Show Prices
Show Prices
Show Prices
Show Prices
Nice Budget Motel
by Basaic written on April 26, 2010
This was a pretty nice Days Inn with the usual extras, a small refrigerator and microwave and a good Wireless. Unlike most Days Inns this one includes a free breakfast at the restaurant next door. Young lady on the front desk was nice.
1 - 1 of 1
- 1
1 - 0 of 0
Nearby Days Inn Devils River Tx
Redo Search in the Map
Updating Map...
Map updates are paused. Zoom in to see updated info.
Also Show
Nearby HotelsSee all 5
Best Value Inn Sonora 3.9 miles away
Best Value Inn-Sonora 3.9 miles away
Best Western Sonora Inn 4 miles away
Comfort Inn Sonora 4.2 miles away
Days Inn Devils River Tx
We've found that other people looking for this hotel also know it by these names:
- Sonora Days Inn
- Days Inn Sonora Devils River Hotel Sonora
Address: 1312 N SERVICE RD, Sonora, TX 76950
Amenities at Days Inn Devils River Tx
- Restaurant
- Swimming Pool
- Wheelchair Accessible
- Free Parking
- Pets Allowed
Sponsored Listings
Sonora Travel Forum
Need advice about Sonora, Texas? Visit the Travel Forum for Sonora and ask our Answer Gurus.


text:
Write to us by regular mail at the following address :
S.A. Ajinomoto OmniChem N.V
Parc Scientifique Fleming
B 1348 Louvain-la-Neuve
Call us or fax us on the following numbers :
Tel : + 32 (10) 48 31 11
E-mail us here or please fill in the following form.
Fill this form please,we will contact you as soon as possible. Fields following by (*) are required
Louvain-la-Neuve (Sales & Marketing)
Wetteren (Production and R&D)


text:
Visit Website
Amenities and extra's abound for our pampered quest. Stay at the beautifully restored 1874 Victorian home in Palestine, Tx. located between Dallas and Houston. The perfect getaway for big city hustle. Palestine is one of the oldest towns in Texas and is ideal for antique hunters, history buffs and anyone looking for a place to get away.
Enjoy the home's beautifully furnished rooms. Pamper yourself with Magnolia Street Inn's bountiful breakfast, professional service and fine amenities. They all combine to make Magnolia Street Inn an outstanding bed and breakfast.
BedandBreakfast.com gift cards are the perfect gift for anyone who needs a relaxing getaway.
Score Breakdown based on15 Reviews
Write A Review
on August 24, 2014
My wife and I have stayed in many B&B s and rate this one of the very best for charm and food. Cindy is a great host and I recommend this B& B to anyone.
Pasadena TX
on May 12, 2014
My husband and I stayed for 2 days in the Bluebonnet room with the Romance package. We enjoyed the wonderful room with the king size bed and the breakfasts were phenomenal. We loved getting up in the mornings and walking around the town. Cindy was fabulous! We didn't want for anything. We enjoyed fresh strawberries dipped in chocolate and champagne after a delicious dinner at Derbies the first night. Then, breakfast in bed the morning we were leaving. We swung on the front porch swing and enjoyed the manicured lawn & flowers. Truly a relaxing and enjoyable experience. I recommend it to all!
on June 10, 2013
I would recommend this B&B to anyone.My husband and I enjoyed every minute. Cindy is the best.
on September 26, 2012
My husband and I were looking for a relaxing place to getaway and enjoy a 'Babymoon' before the birth of our first child. We saw a special on Living Social for this Bed & Breakfast that included chocolate covered strawberries and sparkling cider in the evening and breakfast served in bed the next day, I just couldn't resist :) We stayed in the Library Room which we loved. The bed was super comfortable and we enjoyed the view from the large windows facing the backyard. Breakfast was delicious, you could tell a lot of thought and work went into each dish. Cindy, the innkeeper was very friendly and offered great suggestions on activities and restuarants to visit. One of our favorites was to make reservations at Sabor A Pasion, where Chef Simon cooked us an elaborate 3 course meal that I'm still drooling about. Needless to say, we had a wonderful, relaxing time!
on June 07, 2012
My mom and I recently spent two nights at the Magnolia Street Inn. The house was amazing and filled with so much history, and Cindy was a wonderful host! The rooms were immaculate and breakfast each morning was wonderful. We ended up being the only guests there that weekend, so we had plenty of time to chat with Cindy and watch movies in the downstairs parlor in our bath robes. We'd love to go back again someday, and bring our friends with us! Thanks, Cindy!
on April 29, 2012
I recently purchased a deal from Livingsocial.com in order to get away for the weekend with my husband. We were a little hesitant not knowing the area, but wanted a quiet place to stay. Magnolia Street Inn was perfect. It met our expectation and then some. The breakfast both days were amazing. The room we stayed in was beautiful and the bed was just as comfortable as our bed at home. As for the couple who commented about getting scolded for going in the wrong door, it is true there is no clear entry (the back is beautifully landscaped), but a quick phone call confirmed the use of the front door. We had a great time walking the downtown area and visiting the local winery's suggested by Cindy. Thanks for a great get away.
on April 22, 2012
This was truly a great B&B! A must if you are a B&B fan. We arrived and were treated with the utmost kindness and hospitality we have not had in a long time. The Library was perfect and a turn down service was a pluse. Cindy provided chocolate strawberries, great advise on the town and wonderful conversation. Cindy makes excellent breakfasts which made us stay at the table wanting more. The house is beautiful and took us back in time. Thank you Cindy for a great stay. Definitely a memorable weekend.
on April 11, 2012
The house is BEAUTIFUL and very well kept. The breakfast was delicious. The price was reasonable. The Innkeeper was less than personable, however. There was no clear path from the parking lot to the front door, so we used the back door and she scolded us for doing so. Also, she told us to be SURE and be down at 9:00 the next morning for breakfast as that is when it would promptly be served. We were there at 8:55 and breakfast was not served until 9:15. Only 15 minutes late, yes, but she was adamant about us being there on time. And we were. But breakfast was not. Immediately after breakfast we went to our room to gather our stuff (we had to get on the road). She had asked us earlier to leave our keys on the desk/nightstand in our room. We did so. So we came downstairs to head out and she was talking to another guest. We wanted to give her compliments on the breakfast and so we stood there for a minute while she finished up her conversation and then told her "You did such a good job on that breakfast casserole! It was delicious! We very much enjoyed it. Thank you!" To which her reply was "Oh, you're welcome! Now did yall leave your keys in your bedroom? You made sure and did that, right? You wouldn't believe how many times people take their keys with them!" It just seemed like she completely blew our compliment off and all she cared about was whether or not we had left our keys. Perhaps she was just having a bad couple of days, or maybe we just caught her at a bad moment, but I just felt like she could have been a little more friendly. Would we stay here again? Hmmm.....I don't know if our experience was bad enough to say that we never would. But I definitely wouldn't be opposed to trying somewhere else.
on March 14, 2012
The house was lovely, warm and inviting (and absolutely spotless), but it was Cindy, the Inn Keeper, that made our stay so memorable. Her hospitality, delicious breakfast and personal attention to details, may have spoiled us for other B&B's!
on February 06, 2012
Every detail taken care of. Our room had fresh tulips in the sitting area when we arrived. the king size bed was so comfy! nice private bath and hot shower! very roomy with a southern charm and updated amenities. Breakfast was wonderful and this setting provided a nice relaxing get away weekend for us. We recommend Magnolia Inn to anyone who likes a nice place that is affordable with attention to every detail met!! Great experience!
View More Reviews
Small town
Antique Shopping,
Art Galleries,
Historical interests,
Live Music,
Movie Theater,
Nature area,
Texas State Railroad, Dogwood Trails,
Performing Theater,
Picnic area,
Religious Services,
Air conditioning, Board games, CD player, Library, Telephone ,
IPod docking station/clock radio in quest rooms
Alarm clock, Amenities Basket, Bath robes, Ceiling fans, DVD Player, Desk, Hairdryer, Ironing Board, Radio, Satellite/Cable TV, TV, Wi-Fi
Bird watching, Fishing, Golfing, Hiking trails, Shopping, Sight-seeing, Water sports
Cindy Nesbitt
$100 per night
Innkeepers: Cindy Nesbitt
Guests: 2
Simple! BedandBreakfast.com guarantees you're getting the best price on your bed and breakfast stay when you book your room on BedandBreakfast.com. Within 24 hours of your booking, if you find a better price for the same room on the same date(s) at the same B&B, BedandBreakfast.com will refund the difference to you!
The Best Price Guarantee covers any Bed and Breakfast booked online through BedandBreafkast.com. The Bed and Breakfast must be booked using the Book It button on BedandBreakfast.com in order to qualify.
Just call 1-512-322-2710 within 24 hours of booking and give our customer support representative the details on the lower price you found.
The BedandBreakfast.com Best Price Guarantee ensures that when you book and pay for your reservation online through the BedandBreafkast.com website, you are booking your room at the lowest available price. If you find a lower price for the same room on the same dates at the same B&B, and contact us within 24 hour of making your booking, we will refund the difference in price to you. This guarantee does not apply to bookings made over holidays and/or for special events. All requests are subject to verification by BedandBreakfast.com. BedandBreafkast.com will not accept screenshots or other purported evidence of a lower price that cannot be independently confirmed by BedandBreakfast.com personnel. Nor will BedandBreakfast.com verify any requests that it believes, in its sole discretion, is the result of a printing or other error or is made fraudulently or in bad faith.


text:
Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
If you are reading this message, Please click this link to reload this page.(Do not use your browser's "Refresh" button). Please email us if you're running the latest version of your browser and you still see this message.
Newegg.com - Computer Parts, Laptops, Electronics, HDTVs, Digital Cameras and More!
Batman: Arkham Origins features an expanded Gotham City and introduces an original prequel storyline occurring several years before the events of Batman: Arkham Asylum and Batman: Arkham City. Taking place before the rise of Gotham City's most dangerous villains and assassins, the game showcases a young, raw, unrefined Batman as he faces a defining moment in his early career as a crime fighter that sets his path to becoming the Dark Knight. As the story unfolds, witness identities being formed and key relationships being forged.
Filter Results
Rating: 5/5I love DC and Batman
This review is from: Batman: Arkham Origins Xbox 360
Pros: I Bought this game from gamestop for $37 used and two-four days later saw this brand new in plastic for $29.99 with a free xbox live gift card for $20.00.....Need i say more?
Cons: None at all.
0 out of 1 people found this review helpful. Did you?
Thanks for the valuable feedback you provided!
|Seller Name & Rating
|Offer Details
This item is eligible for Newegg Premier benefits. Are you a Newegg Premier Member? If not, sign up today and get:
Your request will be processed within the next 24 hours.
Please add "firstname.lastname@example.com" to your address book to ensure delivery.See Today's E-Blast Promo
Some manufacturers place restrictions on how details of their products may be communicated.
Some manufacturers place restrictions on how details of their products may be communicated.
Some manufacturers place restrictions on how details of their products may be communicated.


text:
All Recreation Areas
Vicinity Map
Copan Lake
Lake website
Lake Levels
Other Information
Copan Lake
NRM Partnerships
Corps Foundation
VTN Website
Lake Fast Facts
Corps Clearinghouse
Click here
"Corps Watch" Property Protection Program
See the Copan Lake website for additional information. Primary recreational opportunities are listed below.
What Visitors Are Saying....
"The gatekeeper and hosts were friendly, helpful & polite. They seem to enjoy their jobs. Peaceful here; almost tranquil, very relaxing. Felt safe. Appreciate the rangers and staff- and police patrolling--really appreciated the staff & ranger warning my family & me about impending severe storm."
Directions & Lake History/Factoid
Directions: From Bartlesville, Ok 12 miles north on U.S. Hwy 75, turn left on OK Hwy 10W approximately 2 miles to the Project Office.
Lake History
Factoid: About 4,850 acres of water is impounded behind this dam on the Little Caney River. The Corps also holds fee to approx. 12,000 acres of land around the lake that is available for a variety of recreational uses including hunting,& hiking.
Age & Disability Discount Passes
Recreation areas 1 - 5 of 5 at Copan Lake
The appearance of hyperlinks does not constitute endorsement by the U.S. Army of the Web site or the information, products or services contained therein.
Tulsa District
OK Website
Environmental Mgmt
Natural Resources
Watchable Wildlife
Parks & Recreation
Travel Guide
Road Reports
Plan Your Trip!
Copan, OK
Bartlesville, OK
Caney, OK
Local Papers
Google News
Yahoo News
Privacy and Security Notice
Technical Problems
Updated: August 2015


text: We're sorry, Large Owl Magnets is no longer available Why not try one of these instead? Vintage Music Magnetic Note Holders by Altered Chic £4.99$10.81€7.38$8.20 Penguin Pocket Mirror Or Magnet by Joanne Hawker £4.95$10.72€7.32$8.14 'I Love Booze' Magnet Trio by Bottle Bin Embroidery £5$10.83€7.39$8.22 Alphabet Fridge Magnets by all things Brighton beautiful £7.45$16.14€11.02$12.25 Large Owl Magnets by Sally Weatherill £6.50$14.08€9.61$10.69 This item is no longer available free gift wrap £3.45$7.47€5.10$5.67 delivery to United States Receive this item 5-10 working days from dispatch International delivery available we're sorry we're sorry, This item is no longer available buy a gift voucher related categories home > kitchen > storage & organising > magnets by Sally Weatherill Location: Essex, GB read seller's profile see seller's complete range more items from this seller Button Magnet Set £6.95$15.06€10.28$11.43 Owl Mirror £3.50$7.58€5.17$5.75 Animal Badge Set £3.50$7.58€5.17$5.75 Mood Magnet Set £6.95$15.06€10.28$11.43 Lovebird Mirror £3.50$7.58€5.17$5.75 Animal Greeting Cards £19.95$43.23€29.52$32.82 view all you may also like PRODUCT DETAILS DELIVERY RETURNS Made in Britain free gift wrap exclusive ask seller a question save for later Set of four large owl magnets. These cheerful magnets depict four different images of Sally Weatherill's appealing lavender-filled owls. Use them to brighten up the fridge or notice board; they are sure to bring a smile to everyone's face. They also make great small gifts or stocking stuffers for kids of all ages! Made in the UK. made from: plastic, metal and magnets dimensions: 38mm diameter product code: 118695 This product is dispatched to you by Sally Weatherill. Delivery is by 2nd class Royal Mail. MAINLAND UK order now and receive this item by price Free Delivery Saturday 17 October FREEFREEFREEFREE Tracked Two Day Delivery Thursday 15 October £3.95$8.55€5.84$6.49 NON-MAINLAND UK estimated delivery price Highlands & Islands of Scotland 2-5 working daysfrom dispatch FREEFREEFREEFREE Northern Ireland 2-5 working daysfrom dispatch FREEFREEFREEFREE Other UK Islands 2-5 working daysfrom dispatch FREEFREEFREEFREE INTERNATIONAL DELIVERY estimated delivery price Western Europe 2-5 working daysfrom dispatch £2.75$5.95€4.06$4.52 Rest of Europe 5-10 working daysfrom dispatch £2.75$5.95€4.06$4.52 USA & Canada 5-10 working daysfrom dispatch £3.45$7.47€5.10$5.67 Asia & Australasia 5-10 working daysfrom dispatch £3.45$7.47€5.10$5.67 Rest of the world 5-14 working daysfrom dispatch £3.45$7.47€5.10$5.67 You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Sally Weatherill's return policy


text:
Description: Kittylicious - Kitty's Corner - Posts tagged by "Love".
Image was hearted from my.opera.com
Other images from this site
Panita (Booky) was first to heart it
6 people have hearted this image
You might like these too
Now available in your language!Use in your language! Go back to English
Other images from this site
You might like these too
Sign in with Facebook or Twitter to start your gallery.
Sign in with Facebook Sign in with TwitterDon't have Twitter or Facebook? Skip this step!


text:
WWF: Eye chart three
Save endangered animals before they disappear in front of your eyes.
Agency: CC&E, Guangzhou, China
Creative Director: Daming Zheng, Leo Zou
Art director: Liu Yiping
Copywriter: Daming Zheng, Miu Miu
17 comments
Great. This one will pick up lots of awards.....
no idea but it reminded me of: http://blogger.xs4all.nl/images/blogger_xs4all_nl/marcg/21633/o_aminte...
don´t know ... not that great ...
That line ruins a nice ad. 'in front of your eyes...?' Muuuuummmmm! Look what I'm doing! Look how clever I am!
It's like explaining a joke after the punchline. There should be no reference to eyes in it.
I agree. Great ad with a nice little playful idea but the line is a bit corky.
Not that this is a bad execution... it's cool... but my agency has this concept (except it's a fractal m.c. escher of the animals disappearing) hanging up from the mid-eighties... and it's hanging in the loo!


text:
At first glance, Um Batin seems almost familiar. It's as if you've glimpsed something like it before in a TV docudrama, or on the glossy pages of National Geographic or as part of a news clip on CNN. It's part Middle Eastern, part African. It's part dust bowl, part fledgling village....
Tag: High Birthrate
View the most popular tags overall?
Israel confronts shared future with Bedouin citizens
June 28, 2007 | 8:00 pm


text:
Anonymous comments allowed.
#27 - anon (03/19/2012) [-]
High demand of marijuana in US leads to -> a lot of arrestations which leads to -> lot of underpaid workers in jail.
Plus, since it is illegal, price is higher which means government can get more profit if they decide to sell secretely.
Plus, since it is illegal, price is higher which means government can get more profit if they decide to sell secretely.
Reply+5#22 - victoronefourtwo (03/19/2012) [-]
I thought it was banned due to timber companies losing money to hemp products. So the timber companies got it banned with propaganda and such.
#17 - anon (03/19/2012) [-]
-3#36 to #17 - classicgearhead **User deleted account** has deleted their comment [-]
#28 to #17 - CargeLock (03/19/2012) [-]
**** . Does marijuana cause lung cancer? No. Does the marijuana itself harm your lungs? No. Does the smoke/lighter fluid inhalation harm your lungs? Probably. But then again after I finished coughing up the **** there was no shortness of breath/cough and I felt perfectly normal. So I'm not really sure. But I know if I smoke again it's going to be through a vaporizer. No, it's not harmless. It is still less harmful than tobacco/alcohol though and it should be legalized.
Reply+14#16 - brenavia (03/19/2012) [-]
In the early 20th century, hemp farmers were making a lot of money. So much so that in fact it scared the giant cigarette companies of Virginia and Maryland. After appealing to their congressmen, the FDA banned marijuana's production, sale, and consumption. Or we could make an internet comic designed to confuse people. Either or is ok.
#15 - anon (03/18/2012) [-]
Actually, marijuana has almost four times as much tar than a ciggarette. I support it being legal and all, but at least be honest. It's bad for you, just like all drugs are, including cigarrettes.
#23 to #15 - anon (03/19/2012) [-]
Reply+1#14 - durpface (03/18/2012) [-]
I think people just make up random **** sometimes about why cannabis is illegal. I'm not completely sure about why the prohibition started, but the reason it's continuing is because of the ties the pharmaceutical companies have with the FDA and the DEA. It's all just bureaucracy and backdoor deals and corrupt politicians. Ron Paul 2012 to stop the greed, corruption and lies.
#31 to #14 - CargeLock (03/19/2012) [-]
It was originally made illegal because of propaganda made by the lumber companies. They realized that if it were legal and if companies started making paper out of it they would lose a ton of money. So they started a propaganda campaign. There was actually one man who testified in court that after smoking marijuana he sprouted wings and grew fangs and quickly developed a thirst for blood, lol.
#12 - samnoname (03/18/2012) [-]
weed was only made illegal because an Egyptian government wanted to win an election when the international treaty on the misuse of drugs was being written up, they added it as the last minute because their opposition were involved with weed
0#10 - ryderjamesbudde **User deleted account** has deleted their comment [-]
#11 to #10 - NoobPlease (03/18/2012) [-]
where i live in Ontario Canada weed is $10 a gram so $280 an ounce and possession of weed is a fine of $2000 and some years in prison
0#250 to #11 - ryderjamesbudde **User deleted account** has deleted their comment [-]
0#251 to #250 - ryderjamesbudde **User deleted account** has deleted their comment [-]
Reply-1#8 - fogschmog (03/18/2012) [-]
Banning marihuana isnt normal..But on marihuana it is.
Marihuana not even once.
Marihuana not even once.
#7 - anon (03/18/2012) [-]
Another reason would be that it is hard to regulate it because it can be grown anywhere by anyone. Why would people need to buy it from farms if they can plant it themselves cheaply?
Reply+2#5 - denonymous (03/18/2012) [-]
link to an actual movie about marijuana
link to an actual movie about marijuana
Reply-2#3 - Daeiros (03/18/2012) [-]
actually, it's mainly due to this asshole who was the head of the narcotics department, he knew that cocaine and heroin were not gonna be a big enough problem for him to make a name for himself so he wanted to get weed classified as a narcotic(it's not, by definition, a narcotic, so this is a lie) he had a buddy who ran a newspaper company, who also owned tree land for paper to print his papers, and hemp makes more paper per acre then trees do, and it stood to shut down that buisiness, so he printed a ******** of fake stories about kids smoking just one joint, then murding their family in their sleep with an axe, then he went in front of congress with a newspaper clipping, while the head of the medical assosciation stood there with mountains of scientific data, saying it was not only relatively harmless but also had amazing medical benifits, and congress said, but hurr durr, the news says it so it must be true! GTFO science!
#6 to #3 - sphighderman [OP](03/18/2012) [-]
Actually very correct. The comic is essentially an oversimplification of what you just said.
Reply+2#2 - blackrunner (03/18/2012) [-]
-12#4 to #2 - brahandieee has deleted their comment [-]
+1#9 to #4 - kumquatchaos **User deleted account** has deleted their comment [-]
#273 to #9 - brahandieee (04/01/2012) [-]
Oh My Bad. Kinda New. And This Was Like The One Face I Did Not Get. ThankYou.
Back to the content 'True story ... sort of.' Leave a comment


text:
This is for autoblogging. Drink a coffee meanwhile WPeMatico publish your posts. Post automatically from the RSS/Atom feeds organized into campaigns.
You can contribute with WPeMatico
Needed translation files: if you can translate from english to any language, you are welcome.
The .pot file are included on plugin and you must use poedit for tranlate.
Your work, name and website will be mentioned here.
Features supported by Thomas from Invade It Filter images by width or height.
Eli from Eli the Computer Guy
Made an excelent video on Youtube Use WPeMatico to Create a Free WordPress AutoBlog for Legitimate Purposes
Later I've added subtitles and added to Description page of this plugin.
Branco WebHostingGeeks.com.
Romanian & Slovak languages files.
Also we need tutorials on text, pdf, videos. All are welcome. Isn't it?
You can send your files to NetMdP or to e-mail firstname.lastname@example.com
Requires: 3.9 or higher
Compatible up to: 4.3.1
Last Updated: 2015-9-30
Active Installs: 9,000+
10 of 13 support threads in the last two months have been resolved.
Got something to say? Need help?


text:
Terrace Martin has been hard at work on his next project, The 4 Luv Suite. Until we check in with the project on Valentines Day, here's a little taste of what to expect. Sweet! os
Latest Posts
Uncle Murda is on a roll. And this evening, hw rows a few of his raunchy bars over Jeezy and Dos Chainz' collabo. Supa Flex bombs for now.
Who needs color? In support of his recent mixtape, O.E.MO, Nelly Mo and his crew invite us back into the studio for a live version of one of their tracks. We get in more ways than one. And legally too.
After sparking up a few blunts last night, Odd Future's Domo and Wiz Khalifa hit the record button and rocked the mic. How it turned out? Check it out below. Produced by Cardo.
This sounds smooth. Boss Hogg Outlawz' L.E.$ rounds up a few familiar faces for this West Coast-type groove, produced by Da Hit Factory. Menace coming soon. dj mr. rodgers
When this finally drops, it looks like it will surely be a treat. Until it arrives, Music Jones shares what his camera caught during the recent shoot in L.A. Strippers? Body paint? Whoa! UPDATE: Scene shot at Diamonds Of Atlanta. God bless ATLNightSpots. UPDATE 2: Official behind the scenes up top and previous clips after the jump. Let's drop this already!
Obviously this has nothing to do with a back-to-back. Nonetheless, Too $hort got us seeing in twos for his new clip. Be sure to head to the store and get No Trespassing on February 28.


text:
Enroll before September 12, and attend at no cost.
Online women's health fundraising competition starts today.
MakeUp in NewYork closed on September 10th, and organizers say it was a success despite the venue.
Beauty Packaging celebrates its 20th anniversary this month, so we asked a esteemed industry experts for their thoughts.
This singer's lipstick launches online in December.
Breaking down the stereotypes of the Latina woman and her outlook on beauty.
Students and their teachers or parents can win $10,000 in prizes.
L'Oreal has announced its Editor-in-Gloss contest - to choose its first-ever social media guest editor.
Opportunities in at-home hair color kits can boost sales.
Just for Me haircare has launched its #5FingerChallenge Campaign on Instagram.
Breast Cancer Awareness Month begins today.
Allure magazine is featuring the 260 winners of its Best of Beauty Awards 2015.
Sign up now to receive the free weekly newsletter, and more!


text:
Your source for the latest research news
Evidence for Functional Redundancy in Nature
Global Marine Food Chain Collapsing
Bird Family Tree: Hummingbird to Owl
Melting of Antarctic Ice Shelves Accelerating
Algorithm Predicts Male Sexual Orientation
Summer Babies More Likely to Be Healthy Adults
Supercoiled DNA; Not Your Ordinary Double Helix
Quantum Electronics Painted With Beams of Light
Ecotourism Can Put Wild Animals at Risk
Reducing or Eliminating Antibiotic Resistance
Computer Programming News
October 13, 2015
'Psychic Robot' Will Know What You Meant to Do
Darwin on a Chip
Gene Networks Steer a Course for Evolution
Mass Extinctions Can Accelerate Evolution
Latest Headlines
updated 4:43am EDT
New Tool Expands Tracking of Personal Data on the Web
Oct. 9, 2015
Researchers have developed a second-generation tool called 'Sunlight' that matches user-tailored ads and recommendations to tidbits of information supplied by users at a greater scale and level of ...
read more
Frogs Resolve Computing Issues
Oct. 7, 2015
When male Japanese tree frogs sing at the same time, the females cannot differentiate between them in order to choose the best one. Therefore, the would-be suitors have come ...
read more
Theoretical Computer Science Provides Answers to Data Privacy Problem
Oct. 7, 2015
The promise of big data lies in researchers' ability to mine massive datasets for insights that can save lives, improve services and inform our understanding of the world.These data may be generated ...
read more
Predictive Policing Substantially Reduces Crime in Los Angeles During Months-Long Test
Oct. 7, 2015
Crime in Los Angeles dropped dramatically when the Los Angeles Police Department deployed officers based on crime predictions made by a mathematical ...
read more
More-Flexible Machine Learning
Oct. 1, 2015
Researchers have presented a new way of doing machine learning that enables semantically related concepts to reinforce each other. So, for instance, an object-recognition ...
read more
'Performance Cloning' Techniques to Boost Computer Chip Memory Systems Design
Sep. 30, 2015
Computer engineering researchers have developed software using two new techniques to help computer chip designers improve memory systems. The ...
read more
Crunching Numbers: Math Equations Help Build Optimal Bird Wing
Sep. 28, 2015
A researcher uses numbers to show how to build the best wing or fin. Specifically, he wanted to know how flexible the wings or fins should be, so that if an engineer designed a flying or swimming ...
read more
New Method to Predict the Workload for Online Services
Sep. 30, 2015
How can overloads on the Internet be prevented? Cloud computing means that more server space can be rented from large computing resources. Now a researcher has developed algorithms for automatic ...
read more
Computer-Aided Mammography Detection Not Associated With Improved Accuracy
Sep. 28, 2015
Computer-aided detection in screening mammography was not associated with improved diagnostic accuracy in a study that analyzed results from a large Breast Cancer Surveillance Consortium database of ...
read more
New Tech Automatically 'Tunes' Powered Prosthetics While Walking
Sep. 28, 2015
When amputees receive powered prosthetic legs, the power of the prosthetic limbs needs to be tuned by a prosthetics expert so that a patient can move normally -- but the ...
read more
Tracking of Personal Data On the Web
Frogs Resolve Computing Issues
Computer Science Answers Data Privacy Problem
Math Model Helps Reduce Crime
More-Flexible Machine Learning
'Performance Cloning' for Computer Memory
Math Equations Help Build Optimal Bird Wing
New Method Predicts Workload for Online Services
Computer-Aided Mammography Not Better
New Tech 'Tunes' Powered Prosthetics
Latest Videos
from news services
Teach Your Kids To Code With Wonder Workshop's Bots
Buying An Operating System Might Be A Thing Of The Past
Re/code Acquisition: What It Could Mean For The Tech Site
How a Hacker Says He Took Over a Plane's in-Flight Entertainment System
more videos
More Computer Programming News
October 13, 2015
The Science of Retweets
Oct. 6, 2015
What's the best time to tweet, to ensure maximum audience engagement? Researchers have demonstrated that an algorithm that takes into account the past activity of each of your followers -- and ...
read more
Twitter Behavior Can Predict Users' Income Level, New Research Shows
Sep. 29, 2015
The words people use on social media can reveal hidden meaning to those who know where to look. Computer scientists have gone a step further, linking the online behavior of more than 5,000 Twitter ...
read more
Scientists Stop and Search Malware Hidden in Shortened Urls on Twitter
Sep. 25, 2015
Cyber-criminals are taking advantage of real-world events with high volumes of traffic on Twitter in order to post links to websites which contain ...
read more
Protecting Identities in a Sea of Big Data
Sep. 23, 2015
A computer scientist will use three grants to develop approaches to safeguarding sensitive genetic information. Along with co-researchers, he will systematically evaluate potential privacy breaches ...
read more
Personalized Heart Models for Surgical Planning
Sep. 17, 2015
A system that can take MRI scans of a patient's heart and, in a matter of hours, convert them into a tangible, physical model that surgeons can use to plan surgery has been developed to decrease ...
read more
Dew Helps Ground Cloud Computing
Sep. 15, 2015
The most obvious disadvantage of putting your data in the cloud is losing access when you have no internet connection. According to new research this is where 'dew' could ...
read more
Can Typing Habits Prevent Cybercrime?
Sep. 10, 2015
New research proposes a new keystroke algorithm which intends on making online authentication processes more secure, reliable, and cheap. The new method hopes to alleviate some of the common issues ...
read more
Understanding of Complex Networks Could Help Unify Gravity and Quantum Mechanics
Sep. 10, 2015
Mathematicians investigating one of science's great questions -- how to unite the physics of the very big with that of the very small -- have discovered that when the understanding of complex ...
read more
Tinder-Tinkering Artificial Intelligence Could Lessen Left-Swiping
Sep. 9, 2015
An artificial intelligence programme to improve Tinder suggestions has been developed by a post-doctoral researcher who was sick of swiping left. Signing up for an account was one of the first things ...
read more
Customizing 3-D Printing
Sep. 3, 2015
Researchers have designed a new system that automatically turns CAD files into visual models that users can modify in real time, simply by moving virtual sliders on a Web page. Once the design meets ...
read more
Building Efficiency Software Now Available
Sep. 2, 2015
A set of automated calibration techniques for tuning residential and commercial building energy efficiency software models to match measured data is now available as an open source code. The Autotune ...
read more
Identifying Illegal Websites in Photos
Sep. 1, 2015
European computer scientists have developed a way to "read" web addresses in images that could improve filters for blocking pornographic, gambling and other ...
read more
New Technique Lowers Cost of Energy-Efficient Embedded Computer Systems
Sep. 1, 2015
Electrical and computer engineers have developed a new technique for creating less-expensive, low-power embedded systems -- the computing devices found in everything from thermostats to ...
read more
Graphics Processors Accelerate Pattern Discovery
Aug. 28, 2015
Using normal graphics processors, a new program for identifying repeated patterns in complex networks significantly boosts search ...
read more
Searching Big Data Faster
Aug. 26, 2015
For more than a decade, gene sequencers have been improving more rapidly than the computers required to make sense of their outputs. Searching for DNA sequences in existing genomic databases can ...
read more
Supercomputers Enlisted to Shed Light on Photosynthesis
Aug. 26, 2015
Researchers are using high-performance computing to simulate the processes that take place during the first moments of photosynthesis. Using quantum mechanics as the basis, computer scientists, ...
read more
Technology Won't Replace Collaboration Among Students
Aug. 25, 2015
Students heading back to school can always count on one thing: Technology will be a little bit more advanced than it was last year. After all, 21st century learning experiences are increasingly ...
read more
Biophysicists Take Small Step in Quest for 'Robot Scientist'
Aug. 25, 2015
Biophysicists have taken another small step forward in the quest for an automated method to infer models describing a system's dynamics -- a so-called robot ...
read more
Issues Surrounding Security Tools for Software Developers
Aug. 24, 2015
For software programmers, security tools are analytic software that can scan or run their code to expose vulnerabilities long before the software goes to market. But these tools can have ...
read more
Autism: Transforming Behavioral Therapy With Technology
Aug. 24, 2015
Using computer vision, signal processing and privacy protection, a doctoral student, along with electrical and computer engineering professors, have developed "MEBook," a combination of a ...
read more
Tuesday, October 6, 2015
The science of retweets
Tuesday, September 29, 2015
Twitter behavior can predict users' income level, new research shows
Friday, September 25, 2015
Scientists stop and search malware hidden in shortened urls on Twitter
Wednesday, September 23, 2015
Protecting identities in a sea of big data
Thursday, September 17, 2015
Personalized heart models for surgical planning
Tuesday, September 15, 2015
Dew helps ground cloud computing
Thursday, September 10, 2015
Can typing habits prevent cybercrime?
Understanding of complex networks could help unify gravity and quantum mechanics
Wednesday, September 9, 2015
Tinder-tinkering artificial intelligence could lessen left-swiping
Thursday, September 3, 2015
Customizing 3-D printing
Wednesday, September 2, 2015
Building efficiency software now available
Tuesday, September 1, 2015
Identifying illegal websites in photos
New technique lowers cost of energy-efficient embedded computer systems
Friday, August 28, 2015
Graphics processors accelerate pattern discovery
Wednesday, August 26, 2015
Searching big data faster
Supercomputers enlisted to shed light on photosynthesis
Tuesday, August 25, 2015
Technology won't replace collaboration among students
Biophysicists take small step in quest for 'robot scientist'
Monday, August 24, 2015
Issues surrounding security tools for software developers
Autism: Transforming behavioral therapy with technology
Wednesday, August 19, 2015
Algorithm interprets breathing difficulties to aid in medical care
Tuesday, August 18, 2015
Securing data from tomorrow's supercomputers
Friday, August 14, 2015
Programming and prejudice: Computer scientists discover how to find bias in algorithms
Thursday, August 13, 2015
New optical chip lights up the race for quantum computer
Wednesday, August 12, 2015
Bioengineers advance computing technique for health care, more
Computers: Fireflies predict network loyalty
Computers: Protecting your cloud
Tuesday, August 11, 2015
Computer scientists introduce new graphics software
Furthering data analysis of next-generation sequencing to facilitate research
Paving the way for a faster quantum computer
Statistical model helps police identify crime series; speeds apprehension of perpetrators
Monday, August 10, 2015
New mathematics advances the frontier of macromolecular imaging
Tuesday, August 4, 2015
Company triumphs with technology that tests and mass produces electronic devices
Friday, July 31, 2015
Brain-controlled prosthesis nearly as good as one-finger typing
Thursday, July 30, 2015
New fast and free method to make accurate digital line drawings
Wednesday, July 29, 2015
Shoring up Tor: Researchers mount successful attacks against popular anonymity network -- and show how to prevent them
Tuesday, July 28, 2015
Cellphones can steal data from 'air-gapped computers'
Friday, July 24, 2015
Object recognition for robots
Thursday, July 23, 2015
Innovative algorithm is helping scientists decipher how drugs work inside the body
Tuesday, July 21, 2015
New computer program first to recognize sketches more accurately than a human
Tuesday, July 14, 2015
Mathematical model gives fashion advice
Monday, July 13, 2015
Method to untangle, analyze 'controlled chaos' devised
Wireless data delivery over active TV channels tested
Troubleshooting the gene targeting process
Friday, July 10, 2015
Cutting cost, power consumption for big data
Mobile connectivity indoors has just got better
Monday, July 6, 2015
Researchers design a new system to make overtaking safer on highways
Monday, June 29, 2015
New role for Twitter: Early warning system for bad drug interactions
Automatic computer bug repair
Computer learning system detects emotional context in text messages
Thursday, June 25, 2015
Computer vision and mobile technology could help blind people 'see'
Thursday, June 18, 2015
Math students a hit with Minor League Baseball schedulers
Wednesday, June 17, 2015
Scientists create computational algorithm for fact-checking
Network model for tracking Twitter memes sheds light on information spreading in the brain
Monday, June 15, 2015
Turning the Internet of things into the Internet of 'cha-ching'
Thursday, June 11, 2015
Longstanding biology problem put to rest
Wednesday, June 10, 2015
Robot eyes will benefit from insect vision
Tuesday, June 9, 2015
Many experiments for the price of one: Breakthrough in the study of gene regulation
Social media helps young adults quit smoking
Monday, June 8, 2015
Using Minecraft to unboggle the robot mind
Thursday, June 4, 2015
Internet privacy manifesto calls for more consumer power
Planarian regeneration model discovered by artificial intelligence
Wednesday, June 3, 2015
Helping robots handle uncertainty
Tuesday, June 2, 2015
Several popular smart phones fail to reach normal Internet speeds
Monday, June 1, 2015
Genome assembly in minutes: Deciphering the 'book of life' with supercomputers
Thursday, May 28, 2015
Super-efficient light-based computers
Wednesday, May 27, 2015
New algorithm lets autonomous robots divvy up assembly tasks on the fly
Robots can automatically recover from damage in minutes
Making good use of social media
Tuesday, May 26, 2015
Advance in quantum error correction
Scientist created drones that fly autonomously and learn new routes
Friday, May 22, 2015
Robot masters new skills through trial and error
Thursday, May 21, 2015
Designing microwave devices from scratch using computer simulations
Wednesday, May 20, 2015
How video gamers will be able to play in the cloud without guzzling gigabytes
Smarter algorithms ensure more secure chip cards
Tuesday, May 19, 2015
Nerve tracts for the smart city
Monday, May 18, 2015
Computing at the speed of light with ultracompact beamsplitter
First hidden, real-time, screen-camera communication
Thursday, May 14, 2015
Beyond Facebook: The social media alternatives project
Wednesday, May 13, 2015
Digitizing Neurons: Researchers step up to BigNeuron challenge with big computing resources
Tuesday, May 12, 2015
Controlling swarms of cooperative robots with light and a single finger
Friday, May 8, 2015
System designed to label visual scenes turns out to detect particular objects too
Monday, May 4, 2015
Combining computer vision, brain computer interface for faster mine detection
Thursday, April 30, 2015
Online voting a step closer thanks to breakthrough in security technology
Internet as new frontier in collecting data on the mind
Big data reveals classical music creation secrets
Tuesday, April 28, 2015
Human brain inspires computer memory
Monday, April 27, 2015
Computer cooling system could save U. S. $6. 3 billion in electricity a year
Thursday, April 23, 2015
Industrial virtual factory lowers costs and reduces emissions
Reducing big data using ideas from quantum theory makes it easier to interpret
Wednesday, April 22, 2015
Cloud security reaches silicon: System for defending against memory-access attacks implemented in chips
Using smartphones to avoid spatial disorientation of elderly
Thursday, April 16, 2015
Fighting the next generation of cyberattacks
New software analyses the effect of climate change on buildings from the cloud
Monday, April 13, 2015
Graphics in reverse: Probabilistic programming does in 50 lines of code what used to take thousands
Friday, April 10, 2015
Researcher creates software that locates real-time leaks in water, oil or gas pipes
Wednesday, April 8, 2015
Encryption for everyone
Thursday, April 2, 2015
HIV spreads like internet malware and should be treated earlier
Tuesday, March 31, 2015
Unlocking the secrets of the human brain
A robot prepared for self-awareness: Expanded software architecture for walking robot Hector
Load more stories
Top Science
Top Health
Top Physical/Tech
Top Environment
Top Society/Education
Health & Medicine
Mind & Brain
Living Well
Space & Time
Matter & Energy
Computers & Math
Business & Industry
Computers and Internet
Markets and Finance
Computer Science
Artificial Intelligence
Computational Biology
Computer Graphics
Computer Modeling
Computer Programming
Distributed Computing
Information Technology
Mobile Computing
Quantum Computers
Spintronics Research
Video Games
Virtual Reality
Education & Learning
Educational Technology
Neural Interfaces
Math Puzzles
Mathematical Modeling
Plants & Animals
Earth & Climate
Fossils & Ruins
Science & Society
Business & Industry
Education & Learning
Strange & Offbeat
Subscribe for Free
Get ScienceDaily's
Computer Programming News
, delivered daily via email or RSS:
Email newsletter
RSS feed
Most Popular
this week
Blue Skies and Water Ice Discovered on Pluto
Wet Paleoclimate of Mars Revealed by Ancient Lakes at Gale Crater
Perfectly Accurate Clocks Turn out to Be Impossible
Nobel Prize in Physics for 2015
Chernobyl: At Site of World's Worst Nuclear Disaster, the Animals Have Returned
Caution: Weird Material Shrinks When Warm
Nobel Prize in Chemistry 2015
Dirt-Cheap Catalyst May Lower Fuel Costs for Hydrogen-Powered Cars
Scientists Build a Digital Piece of a Rat's Brain
'Psychic Robot' Will Know What You Really Meant to Do
Crucial Hurdle Overcome in Quantum Computing
Light-Based Memory Chip Is the First Ever to Store Data Permanently
Strange & Offbeat
Wet Paleoclimate of Mars Revealed by Ancient Lakes at Gale Crater
Mysterious Ripples Found Racing Through Planet-Forming Disc
Perfectly Accurate Clocks Turn out to Be Impossible
Where to Look for Life? Astronomers Devise 'Habitability Index' to Guide Future Search
New Optoelectronic Probe Enables Communication With Neural Microcircuits
Scientists Produce Shortest Electron Bunches Ever by Surfing Plasma Waves
Researchers Develop Deep-Learning Method for Computers to Predict Daily Activities
Caution: Weird Material Shrinks When Warm
Scientists Build a Digital Piece of a Rat's Brain
'Psychic Robot' Will Know What You Really Meant to Do
Frogs Resolve Computing Issues
Back to the Future: Science Fiction Turns Science Fact
Other News
Chilean scientists create contraceptive vaccine for dogs
Gene editing could pave way for pig organ transplants: U.S. study
Florida circus elephants find second career in research
Nobel laureate chemist Richard Heck, 84, dies in Manila
Nestle spends $70 million on U.S. health science hub
As U.S. insurers aim to get bigger, hospitals eye health plan entry
NZ police arrest man over infant formula contamination threat
Merck cholesterol drug's odds dim after Lilly failure
Wine at dinner safe, possibly beneficial in diabetes
Age-associated financial vulnerability often overlooked
Australia says strong Indian Ocean Dipole reinforcing El Nino
Washington state man who moved a river ordered to pay restitution
Investors ask automakers to explain emissions lobbying
Wildfires burn homes, prompt evacuations in Wyoming, Idaho
Zimbabwe will not charge U.S. dentist for killing Cecil the lion
Driverless buses, platoons of trucks to shape Singapore's transport future
SAP third-quarter operating profit beats estimates on mature markets
Cyber insurance premiums rocket after high-profile attacks
Dell to buy EMC in $67 billion record tech deal, aims for cloud market
PepsiCo says to market mobile phones, accessories in China
Toggle navigation
Home Page
Top Science News
Top Science Videos
Latest News
Latest Videos
Home Page
Top Science News
Top Science Videos
Latest News
Latest Videos
View all the latest
top news
top videos
in the health sciences,
or browse the topics below:
Health & Medicine
Alternative Medicine
Birth Control
Heart Disease
HIV and AIDS
Stem Cells
more topics
Mind & Brain
ADD and ADHD
more topics
Living Well
Sexual Health
Skin Care
Men's Health
Women's Health
Diet and Weight Loss
Healthy Aging
more topics
View all the latest
top news
top videos
in the physical sciences & technology,
or browse the topics below:
Matter & Energy
Fossil Fuels
Quantum Physics
Solar Energy
Wind Energy
more topics
Space & Time
Black Holes
Dark Matter
Extrasolar Planets
Solar System
Space Telescopes
more topics
Computers & Math
Artificial Intelligence
Computer Science
Quantum Computers
Video Games
Virtual Reality
more topics
View all the latest
top news
top videos
in the environmental sciences,
or browse the topics below:
Plants & Animals
Agriculture and Food
Endangered Animals
Genetically Modified
Microbes and More
New Species
more topics
Earth & Climate
Global Warming
Ozone Holes
more topics
Fossils & Ruins
Ancient Civilizations
Early Humans
Early Mammals
Lost Treasures
Origin of Life
more topics
View all the latest
top news
top videos
in the social sciences & education,
or browse the topics below:
Science & Society
Arts & Culture
Political Science
Privacy Issues
Public Health
Racial Disparity
World Development
more topics
Business & Industry
Biotechnology & Bioengineering
Computers & Internet
Energy & Resources
Medical Technology
more topics
Education & Learning
Animal Learning & Intelligence
Educational Psychology
Educational Technology
Infant & Preschool Learning
Learning Disorders
STEM Education
more topics
Top News
Top Videos
Human Quirks
Odd Creatures
Bizarre Things
Weird World
Full View


text:
Sort type: [Top] [Newest]
When airports hire what are all to often thugs, people with criminal histories or homeless people as baggage smashers at way to many airports what else can you expect?
They were also videoed stealing from bags in the belly of the aircraft and while taking gate checked bags down the jetway.
And some wonder why others never check their bags. I personally rarely found the baggage service valuable when it was free. I rarely checked bags, even back then. Now that tgere is a charge, I certainly don't see the value proposition for the service.


text:
Sold Out
The Nolan Stainless Steel Bar Chair features strong lines and a durable construction, great for anywhere from the home to a high traffic entertainment venue.
Product Dimensions:
Width: 15"
Depth: 15"
Height: 37"
Seat Width: 14"
Seat Depth: 14"
Seat Height: 29.5"
$578.00 - Sold Out
With a solid rubberwood frame, the versatile Aaron Sofa is a subtle prescence in any room. It has a white leatherette cover with a warm walnut toned frame. Classic Mid-Century style for any small space.SpecificationCover: LeatheretteFinish: RubberwoodDimensions29L x 65.4W x 28.7H inches / 55 lbsSeat Height: 15.7 inchesSeat Width: 60 inchesSeat Depth: 20 inchesAssembly RequiredShips within 2-3 days
The Ackerman Bench represents the new style and utility in dining. With a comfy back and beautiful design features such as tufting and chrome legs, this bench is a great way to put fashion in your communal dining. It comes in black, white, or taupe leatherette.SpecificationsCover: LeatheretteFinish: Stainless SteelDimensions21.3L x 61W x 17.5H inches / 55 lbsSeat Height: 17.5 inchesSeat Width: 61 inchesSeat Depth: 18.9 inchesShips within 2-3 days
$290.00 - Sold Out
The whimsical design and gently curved seat add character to any table. The Alamo Square chair is 100% Elmwood. Part of the Modern Era Collection Product Dimensions: Width: 20" Depth: 20" Height: 41.3" Seat Width: 19.7" Seat Depth: 17.7" Seat Height: 17.7"


text:
- Hot Animes This Season
- Overlord,
- Charlotte,
- Gangsta,
- Gate,
- Rokka no Yuusha,
- God Eater,
- Monster Musume,
- Durarara!X2 Ten,
- Akagami no Shirayuki
NANA Episode 42
Watch NANA Anime Episode 42 for free with English Subbed. View NANA Episode 42 Online.
if NANA – Episode 42 are not working, please try one of the Video Mirrors.
Upload by: mica
Updated: November 13, 2012
You are watching NANA Episode 42 in High Quality English subbed. NANA Episode 42 is from NANA anime series. If you enjoyed NANA Episode 42 please share it with others! Please note that this Episode is hosted on a third-party video sharing website, and it is not affiliated with Chia-Anime.
Anime › NANA › Episode 42


text:
MOT Testing Stations in Liverpool
Be the first to review
Cusson RoadKnowsley Industrial ParkMOT, KIRKBY, L33Knowsley Industrial ParkLiverpoolMerseysideL33 7BY
Show map
0151 54...
0151 548 6825
All fields are required. Your review will appear immediately.
By leaving this review, you agree with our Terms of membership
Similar nearby businesses
Victoria Business Park, Liverpool, L24 9NB
20 Esk Street, Liverpool, L20 8JT
57 Hill Street, Liverpool, L8 5SA
6 Wheathill Industrial Estate, Liverpool, L27 0YA
232 Priory Road, Liverpool, L4 2SL
125 Northumberland Street, Liverpool, L8 8AY
© 2015 Scoot - part of the network


text:
Ferry Operators
The fast, friendly and frequent Isle of Wight connection
Established in 1965, Hovertravel is celebrating its golden anniversary this year. As the only passenger hovercraft service in Europe, it provides a unique way to travel between Southsea, Portsmouth and Ryde on the Isle of Wight.
Travelling at just 1.5 metres above the sea, this is the fastest ferry journey across the Solent. It is the world's only scheduled passenger hovercraft and crosses to the Isle of Wight in just 10 minutes.
Hovertravel crosses the Solent from Southsea, Portsmouth to Ryde, Isle of Wight in under ten minutes.
Its craft hover over land and sea meaning that they don't need a pier and can drop passengers off directly on the shore.
With terminals that are highly accessible for coach & bus transfers and with convenient parking close by, Hovertravel is ideal for a day trip or holiday on the Isle of Wight.
Hovertravel's Hoverbus is the perfect way to travel around Portsmouth and Southsea and has fantastic rail connections.
Take advantage of Hovertravel's group discounts, priority boarding, help from friendly staff and free luggage transfer.
Hovertravel has plenty of great value combined travel and attraction tickets for both the Isle of Wight and Portsmouth.
Travelling across the Solent on a cushion of air in under ten minutes with Hovertravel is a unique experience and with such quality service the hovercraft journey will be truly memorable.
Hovertravel's hovercraft offer a frequent service to the Isle of Wight
Hovertravel offers a year-round passenger service. During commuter times there is a crossing every 15 minutes to make connecting onto onward transport even easier. Outside of these times, in the summer Hovertravel operate a crossing every 30 minutes and in the winter every hour.
At a Glance
Hovertravel Special Offers More..
Celebrate 50 years of Hovertravel service on Tuesday with half-price travel
Hovertravel is celebrating 50 years of continuous operation by offering half price travel on Tuesday (4 August). More...
Related News More headlines...
Stay out later at the Victorious Festival this weekend thanks to Hovertravel
Hovertravel are laying on extra late services so that Isle of Wight residents can spend longer at the Victorious Festival… More...
Hovertravel resumes normal service as Freedom 90 returns
Hovertravel has welcomed the return of its second craft, Freedom 90, which means its summer timetable resumed bright and early… More...
- There are no related fleet entries.
There are currently no related galleries.


text:
Gary Williams is retiring as Maryland's basketball coach, a source confirmed to CBSSports.com on Thursday.
Williams subsequently confirmed the news with a released statement.
"It's the right time," Williams said. "My entire career has been an unbelievable blessing. I am fiercely proud of the program we have built here. I couldn't have asked any more from my players, my assistant coaches, the great Maryland fans and this great university. Together, we did something very special here."
Williams spent 22 seasons at Maryland and led the Terrapins to the 2002 national championship while making 14 NCAA tournament appearances, seven Sweet Sixteens, two Elite Eights and two Final Fours. In recent years, though, he struggled recruiting the Washington D.C./Baltimore area and had grown tired of the summer culture where most high-major recruiting now takes place, a source said. Williams had not made the Sweet Sixteen since 2003. The Terrapins were 19-14 overall, 7-9 in the ACC last season. Their best player, Jordan Williams, announced on Wednesday that he is hiring an agent and staying in the 2011 NBA Draft.
The Maryland job is now the biggest available job from this offseason.
Coaches widely consider it to be one of the nation's best jobs because of its natural recruiting base.
"The right guy there will kill it," a source told CBSSports.com. "If they get the right guy, they'll win really big."
Blog Entry
Williams retiring from Maryland
Posted on: May 5, 2011 4:35 pm
Edited on: May 6, 2011 10:04 am
Category: NCAAB
Tags: Gary Williams, Maryland
Since: Oct 23, 2006
Posted on: May 5, 2011 5:44 pm
Source: Williams retiring from Maryland
This is a sad sad day for the extended Maryland family.
It seemed like coach Williams would be there forever.
I guess the time was right. His passion and teaching was not enough to overcome the lack of talented players.
Big time college sports just chew up those guys who want to do it the right way and teach young men.
Gary could not bring himself to "Calipari" his way into the AAU game and modern recruiting gray areas. He stepped aside before he compromised his stance.
I hope retirement treats this legend well.
Go Terps.
Since: Jul 27, 2009
Posted on: May 5, 2011 5:43 pm
Source: Williams retiring from Maryland
I was there through the rise up, reaching the pinnacle, and striving for more... but the pinnalce is like one's first gf/love... it's never as good as the first time - wow, it was a great ride - thanks coach!!!
Since: Jun 18, 2008
Posted on: May 5, 2011 5:39 pm
Source: Williams retiring from Maryland
Happy trails Coach Williams. Love that guy.
Since: Jan 10, 2008
Posted on: May 5, 2011 5:36 pm
Source: Williams retiring from Maryland
I wish Coach Williams the best of luck and enjoy the retired life. He did an outstanding job as the coach for Maryland and cleaned up a program that was in trouble because tge death of an outstanding basketball player that I have decided to not mention his name.. The university will have a tough time filling his shoes. The ACC is a tough conference to coach in and Williams earned the respect from all the fellow coaches in the ACC.
Since: Jan 4, 2009
Posted on: May 5, 2011 5:34 pm
Source: Williams retiring from Maryland
an absolute fixture in the NCAA coaching scene. Outside of Coach K and Calhoun, there was no other coach I respected as much as Gary Williams. Despite having what many would see as subpar talent, he managed to make his units work cohesively every year.
Despite all the jeering we've given you over the past decades, we'll miss you in Cameron Indoor Stadium.
Since: Sep 29, 2009
Posted on: May 5, 2011 5:30 pm
Source: Williams retiring from Maryland
Gary is a great coach and will be missed. Maryland salutes you !
Since: Feb 7, 2010
Posted on: May 5, 2011 5:27 pm
Source: Williams retiring from Maryland
Next to Coach K and Dean Smith, a face of the ACC for 2+ decades. The new AD wasn't doing an extension. Fridge and Gary in same season - no coincidence. AD Anderson aspires to turn my Terps into the Army of the ACC.
Since: Aug 18, 2006
Posted on: May 5, 2011 5:26 pm
Source: Williams retiring from Maryland
Washington Post is reporting that Gary got in a few digs at Debbie Yow on the way out the door. Those two will forever snipe at each other.
Since: Dec 1, 2008
Posted on: May 5, 2011 5:18 pm
Source: Williams retiring from Maryland
Great coach, one of my favorites and also had a great run at Boston College.
Since: Aug 1, 2007
Posted on: May 5, 2011 5:11 pm
Source: Williams retiring from Maryland
maryland basketball will never be the same. this is depressing. gary isnt retiring, he's "retiring". one of the greatest COACHES of all time. notice i emphasized the word coach. sorry he couldent be john calipari. then again he never had the ncaa infractions committee sniffing around the md program. so im not sorry.


text:
Vinfolio gives you full control of your shipping preferences by letting you choose the exact day your wines ship out and at what speed. Orders placed before 11am PST may be shipped the same day.
Vinfolio Safe Shipping: Between November and June, we use an automated Weather Check system to ensure your wine is not shipped when temperatures are over 75°F or under 20°F. All ready-to-ship orders default to the Safe Shipping option during this time and will ship only on a Monday or Tuesday, so that it arrives no later than Friday of a given week.
Weather Hold: If your order is held due to weather, you will be notified by email, and we will attempt to re-ship your order the following week, after again checking the temperature forecast. If adverse temperature conditions are still present, orders will again be placed on weather hold. You may choose to release the Weather Hold at any time, either by email or by calling Customer Care.
Please note that during the summer months, all wine is shipped at the customer's own risk using either Temperature Control or Overnight Morning delivery only.
Standard Shipping: This may be the right choice for you if you need wine to arrive at its destination by a specific date (e.g., for an event). We always recommend using the fastest option possible to protect your wine, but for this option, you may decide when you want to ship. (Please note, this option is at Customer's own risk, and releases Vinfolio from any responsibility for temperature-related damage.)
We are currently able to ship directly to the following states as local guidelines dictate. If for some reason you are looking to receive your wines elsewhere, please contact us at firstname.lastname@example.com or call us at (800) 969-1961 to discuss alternative options or long-term storage opportunities. We look forward to finding a solution that fits your needs.
District of Columbia
New Mexico
New York
North Carolina
North Dakota
South Carolina
Local Delivery Services: Vinfolio offers local delivery services in the San Francisco Bay Area plus Napa and Sonoma counties in our 55° temperature-controlled vans.
Local Delivery Fees: Local delivery costs $12 per carton with a four-carton minimum ($48 minimum charge) and are subject to route availability. For requests that cannot be accommodated using our vans, we may be able to arrange an alternative and quote you the rate we are given.
Wine in transit (via our vans, FedEx, or others) is fully insured for up to $100 per shipment at no charge when arranged by us (additional coverage is available upon request). This insurance covers missing shipments, breakage, and other non-temperature related damage. (See Vinfolio Safe Shipping above as a means of protecting your wine from temperature-related damage).