text:
Last Vegas
- Studio: CBS Films
- Release Date: Nov 1, 2013
Critic Reviews
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Last Vegas is an entertaining movie with a lot of integrity, and it gives all of its actors - all heavyweights and Oscar winners - real moments to dig in and play something.
There's virtually nothing subtle or surprising about the story, and yet one can't help but smile throughout watching five Academy Award-winning actors breezing their way through an obvious but lovely and funny adventure.
As Last Vegas glides along, satisfying expectations while always aiming low, it makes peace with being inoffensively mediocre. Like Vegas itself, the story goes down easy, but its appeal is hard to remember once you leave it behind.
Although formulaic in design and programmed to meet its quota of laughs, the film makes a point of going beyond basic expectations into some legitimate aspects of mature friendships without getting soggy about it.
Nostalgia counts a lot and needs to, with this sitcom-level material and Jon Turteltaub's uninspired direction.
After a while, you truly start to see the formula gears churning, but given that, it helps to have an actress like Mary Steenburgen, who at 60 still possesses an amazing glow, as well as a snappier comic timing than ever.
The picture begins vanishing from the memory the instant that its final credits roll, and its laid back attitude suggest it's fine with that.
Special kudos to Freeman, who kills it on the dance floor and later while drunk off his ass on vodka and Red Bull. You'll groan as much as howl at the jokes, but the veteran stars have a ball acting their age. Even when all else fails them, they're good company.
It's the actors, plus an exuberant Mary Steenburgen as quick-witted lounge singer Diana, who make the movie more than a middling copycat.
A genial "Hangover" for the AARP set, Last Vegas is roughly what you'd expect, or fear, but a little better.
Last Vegas isn't "out there" in a "Hangover" sense. It's comical comfort food, with actors doing the sorts of things they've done for decades. But even if this is the safest Vegas romp of them all, this cast never lets us forget that we're in very good hands.
It certainly doesn't hurt that Douglas, De Niro, Freeman, and Kline are just plain fun to watch together. As predictable and occasionally uncomfortable as Last Vegas can be, it's an assured crowd-pleaser.
While it's as tacky and obvious as Sin City itself, this comedy is watchable thanks to a lively pace and spirited turns from Kline and Steenburgen. An unabashed old-timers' fantasy.
Last Vegas is a good-natured bimbo of a movie, it'll do just about anything to please you, though luckily that includes delivering the 20 big laughs you feel you're owed (unlike The Hangovers), and gently jerking a tear or two. You enjoy it in spite of yourself.
The film's hidden asset is the luminous Mary Steenburgen, funny and gorgeous as an empty-nest mom turned lounge chanteuse who beguiles the dudes with age-appropriate flirting and arch humor.
Rote ageist jokes abound ("Do you guys have drugs?" asks a bachelorette; "Does Lipitor count?" responds Kline), but they come with an inclusive, self-deprecating spirit that grows more endearing over the duration.
It's still a bit early in the long careers of these actors, especially Kline, to be playing creaky codgers. It's bad enough when Hollywood casts women over the age of 30 as grandmothers-in-waiting. Now we have to endure an onslaught of famous veteran actors complaining about their hips.
Yes, it's uneven, more jokes miss than hit, and it winds up taking easy dramatic shortcuts from the more interesting avenues that the script presents, but it's thanks to the lead quartet that the comedy is as engaging at it is.
It has the sensibilities of a late-'80s/early-'90s forgettable big-screen sit com and probably won't find many interested viewers who aren't card-carrying AARP members.
We know where it's going, and it doesn't take long to get there. There are some good jokes along the way, a few of them blandly off-color.
The film at least achieves the level of mediocrity thanks to the professionalism of two slightly younger participants — Kline and Mary Steenburgen, who also have Oscars on their mantels but go well beyond phoning it in here.
Alas, this all-star ensemble comedy that trumpets (too loudly) that it's a "Hangover" on hemorrhoid cream musters enough laughs to be passable, if not memorable. And that's thanks to Morgan Freeman's showmanship.
A smattering of funny gags and the nostalgia value of the cast — none of whom, curiously, have ever shared the screen before — keeps the whole thing more watchable than it has any right to be.
If you approach Last Vegas expecting an emotionally engaging, in any way surprising, moviegoing experience, you will be disappointed. But if you want the equivalent of an old-fashioned television variety show — a Very Special Evening with Robert De Niro, Morgan Freeman, Michael Douglas and Kevin Kline — you might not have such a bad time.
Though coming off at times like Adam Sandler's "Grown-ups," only with Oscar winners, Last Vegas is a genial little comedy for the crowd it's intended for.
It's delightful to see these acting pros hamming it up in this movie. They look as though they're having a blast. The same can't be said for the audience.
It's the geriatric equivalent of a ramshackle teen sex comedy, only intermittently elevated by the caliber of the talent involved.
In trying to lift this lame schtick, De Niro, Douglas, Freeman and Kline are stand-up guys, but Last Vegas is a case of erectile dysfunction.
It's all predictable and, despite the best efforts of Turteltaub and screenwriter Dan Fogelman at something a little risky, it's pretty lame.
Somewhere between John Cassavetes's "Husbands" (1970) and "The Hangover" (2009) you will find Last Vegas. Not necessarily a bad place to be, except the film unfortunately has the madcap hilarity of the former and the emotional intensity of the latter.
The high point of Last Vegas is also arguably the low point of Robert De Niro's career.
The film is depressing, sub-sitcom fodder that will dull whatever affection you may still harbor for these legendary actors.
User Score
Generally favorable reviews- based on 110 Ratings
User score distribution:
Positive: 18 out of 35
Mixed: 13 out of 35
Negative: 4 out of 35
Nov 3, 2013"Last Vegas" stars Michael Douglas, Robert De Niro, Morgan Freeman and Kevin Kline in what can best be described as a senior citizen's"Last Vegas" stars Michael Douglas, Robert De Niro, Morgan Freeman and Kevin Kline in what can best be described as a senior citizen's "Hangover" where, as in that film, lifelong friends also experience a bachelor party in Vegas. That, however, is where the likeness ends for "lifelong" in this film means men who have been friends for over 60 years and have gone through many of life's trials and tribulations together. This movie is geared for and will be enjoyed most by older movie goers who can identify with Cholesterol and PSA numbers versus baseball statistics and who can understand that phone calls from friends you haven't heard from in many years don' always bring happy news. Well directed by Jon Turteltaub with a screenplay by Dan Fogelman, Messrs. Douglas, De Niro, Freeman and Kline get a chance to display their comedic and dramatic talents while ably abetted by a sparkling and charming Mary Steenburgen, all while in the venue of Las Vegas and, more specifically, Binion's Hotel and the Aria Resort complex. Though the jokes may be old, they are delivered well and make for a relaxed and nice viewing experience. This is not a great film nor will it win many awards but it does give the audience an opportunity to sit back and enjoy the exploits of these senior citizens as they seek new goals, heal old wounds and cement quality relationships. I give the film a 7 and recommend it to all who believe that life doesn't necessarily end but can, in fact, begin over 70.… Full Review »
Nov 2, 2013Pure fantasy for people who need to escape. This is a story of what happens when everything goes right in Vegas. It does not all have to makePure fantasy for people who need to escape. This is a story of what happens when everything goes right in Vegas. It does not all have to make sense or be completely believable because it is all about having fun and solving a few issues in the process of having all that fun. That being said if you also want to have a great time in Vegas just see this movie. The real life stories usually don't end with you leaving the table with 120 grand, and you don't have to wait on your plane to arrive at the airport. Movie ticket much cheaper than real Vegas every time.… Full Review »
Apr 6, 2014Wasted talents for this movie. Predictable, bored, cliche, easy jokes. The names didn´t make any difference for the development of the movie.Wasted talents for this movie. Predictable, bored, cliche, easy jokes. The names didn´t make any difference for the development of the movie. Everything solves really easy at the end.… Full Review »


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Page 1
Structure-Activity Relationship and Substrate-
Dependent Phenomena in Effects of Ginsenosides on
Activities of Drug-Metabolizing P450 Enzymes
Miao Hao1, Yuqing Zhao2, Peizhan Chen1, He Huang3, Hong Liu3, Hualiang Jiang3, Ruiwen Zhang4, Hui
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate
School of the Chinese Academy of Sciences, Shanghai, People's Republic of China, 2Shenyang Pharmaceutical University, Shenyang, People's Republic of China, 3Drug
Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China, 4Department of Pharmacology
and Toxicology, Division of Clinical Pharmacology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Ginseng, a traditional herbal medicine, may interact with several co-administered drugs in clinical settings, and
ginsenosides, the major active components of ginseng, may be responsible for these ginseng-drug interactions (GDIs).
Results from previous studies on ginsenosides' effects on human drug-metabolizing P450 enzymes are inconsistent and
confusing. Herein, we first evaluated the inhibitory effects of fifteen ginsenosides and sapogenins on human CYP1A2,
CYP2C9, CYP2C19, CYP2D6 and CYP3A4 enzymes by using commercially available fluorescent probes. The structure-activity
relationship of their effects on the P450s was also explored and a pharmacophore model was established for CYP3A4.
Moreover, substrate-dependent phenomena were found in ginsenosides' effects on CYP3A4 when another fluorescent
probe was used, and were further confirmed in tests with conventional drug probes and human liver microsomes. These
substrate-dependent effects of the ginsenosides may provide an explanation for the inconsistent results obtained in
previous GDI reports.
Citation: Hao M, Zhao Y, Chen P, Huang H, Liu H, et al. (2008) Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on
Activities of Drug-Metabolizing P450 Enzymes. PLoS ONE 3(7): e2697. doi:10.1371/journal.pone.0002697
Editor: Jennifer Keiser, Swiss Tropical Institute, Switzerland
Received February 26, 2008; Accepted June 19, 2008; Published July 16, 2008
Copyright: ? 2008 Hao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported in part by a grant (06DZ19021) from the Science and Technology Commission of Shanghai Municipality, Pujiang Talent
Program (06PJ14107), a grant (2007CB947100) from the Ministry of Science and Technology of China (973 Program) and the Knowledge Innovation Program of
Chinese Academy of Sciences, Food Safety Research Center and Key Laboratory of Nutrition and Metabolism in INS. R.Z. was supported in part by NIH/NCI grants
R01 CA112029 and R01 CA121211. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
* E-mail: email@example.com
With the increasing use of alternative medicine and a wide
spread of combination therapies for various diseases, there is an
increasing interest in determining drug-drug, drug-nutrient, and
drug-dietary supplements interactions. For example, Panax ginseng,
a traditional herbal medicine used in the Eastern Asia for more
than 2000 years [1], is presently being used worldwide as one of
the most common complementary alternative medicines. Ginseng,
the root of Panax ginseng, has diverse pharmacological activities,
including effects on the central nervous system, antineoplastic and
immunomodulatory effects [2]. In the clinical settings, however,
co-administration of ginseng or its extracts with other therapeutic
agents (e.g. warfarin, digoxin and phenelzine) may lead to ginseng-
drug interactions (GDIs) [3,4]. Ginsenosides (Fig. 1a), the major
active components of ginseng, may account for the GDIs and
other adverse effects [5]. It is postulated that most metabolic drug-
drug interactions can be attributed to inhibition or induction of
drug-metabolizing cytochrome P450 (CYP or P450) enzymes [6].
Therefore, we hypothesized that investigations on the effects of
ginsenosides on P450s will help elucidate the mechanism of GDIs.
Unfortunately, the reported effects of ginseng extracts or ginseno-
sides on P450s are inconsistent, even confusing. For instance,
ginsenoside Rd weakly inhibits CYP3A4 and CYP2D6 and inhibit
CYP2C19 and CYP2C9 to an even lesser extent; and ginsenosides
Rb1,Rb2,Re,andRg1do notsignificantlyaffect CYP1A2,CYP2C9,
CYP2C19, CYP2D6 or CYP3A4 [7]. In another study, however,
ginsenosides Rd and Rb2inhibited CYP2C19-dependent S-mephen-
ytoin 49-hydroxylation and Rd inhibited CYP2D6-mediated bufur-
alol 19-hydroxylation [8]. Moreover, standardized Panax ginseng and
Panax quinquefolius extracts decrease the 7-ethoxyresorufin O-deal-
kylation activities of human CYP1A1, CYP1A2, and CYP1B1, but
ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf or Rg1have no significant
effects [9]. Additionally, GDIs are probably mediated by ginsenoside
metabolites (e.g. protopanaxadiol and protopanaxatriol) rather than
enterobacteria before they enter the circulation [11]. To date, some
80 ginsenosides have been isolated from Panax species [12] and new
ginsenosides are being found. Recently, we identified and character-
ized two novel potent antitumor ginsenosides, 20(R)-dammarane-3b,
12b, 20, 25-tetrol (25-OH-PPD) [13] and 20(S)-25-methoxyl-
dammarane-3b, 12b, 20-triol (25-OCH3-PPD) [14]; their effects on
P450s are still unknown.
We also speculated that there are structure-activity relationships
(SAR) for the effects of ginsenosides on P450s. Although several
ligand-based and structure-based models have been established for
PLoS ONE | www.plosone.org1 July 2008 | Volume 3 | Issue 7 | e2697
Page 2
substrates and/or inhibitors of P450s [15], the SAR of the effects
of the ginsenosides on P450s were rarely addressed. In the present
study, we systematically evaluated the effects of 15 ginsenosides
and sapogenins (Fig. 1A) on five major human drug-metabolizing
P450 enzymes with commercially available VividH substrates to
use as probes (Fig. 1B). Subsequently, the SAR for these effects was
explored to generate new knowledge about ginsenoside-P450
interactions at the molecular level. Moreover, we also selected
different fluorescent and conventional probes to determine
whether the effects of different ginsenosides on CYP3A4, a key
P450 enzyme with the largest substrate repository, are substrate-
and analog-dependent.
Ginsenosides and sapogenins affect P450 enzymes in an
analog- and enzyme-dependent manner
The parameters used to determine the activities of the P450
enzymes are summarized in Table 1. Reported potent inhibitors of
respective P450 enzyme were evaluated to validate the efficiency
of these fluorescent assays (Table 2). These inhibitors show
comparable activities against respective P450s to the documented
reports [16–19]. Additionally, the inhibitory effects of methanol, a
vehicle used in the study, were carefully evaluated. Methanol at
the final concentration of 1% had no significant inhibitory effect
Figure 1. Structures of ginsenosides (A), and VividH fluorescent probes (B). Note: a. The C-20 configurations of the test ginsenosides are
20(S) except when indicated behind the substituent groups in this column. b. Glc: b-D-glucopyranosyl; Xyl: b-D-xylopyranosyl; Rha: a-L-
rhamnopyranosyl. Numerical superscripts indicate the carbons at glucosidic bonds. c. C-K: ginsenoside Compound K. d. PPD: protopanaxadiol; PPT:
SAR of Ginsenosides on P450s
PLoS ONE | www.plosone.org2July 2008 | Volume 3 | Issue 7 | e2697
Page 3
against VividH blue metabolism by CYP1A2 or green metabolism
by CYP3A4, and had minimal inhibition against VividH blue
metabolism by CYP2C19 (Table 2). However, 1% methanol
significantly inhibited VividH CYP2C9 red metabolism (by 42.4%)
and blue metabolism by CYP2D6 (27.5%). At the final
concentration of methanol of 0.5% or 0.1%, the inhibition against
substrate metabolism by methanol was all either negligible or
within an acceptable range (Table 2).
Subsequently, we determined the effects of the ginsenosides and
sapogenins on five major cDNA-expressed P450 enzymes. The
compounds had weak inhibitory effects against CYP1A2, with the
exception of Rb1, Rg3, and Compound K (C-K) which had
moderate inhibitory effects with IC50 values less than 50 mM
(Table 2). Ginsenosides Rg3, Rh2, and C-K and all sapogenins
exhibited moderate inhibition against CYP2C19, while they more
potently inhibited CYP2C9 and CYP3A4 (green substrate)
Table 1. Parameters of the enzymatic reactions used to determine the activities of P450 enzymes.
VividH assay
concentration (mM)
Wavelengths (nm)
concentration (nM)
Linear range of
RFU,t curve (min)a
Excitation emission
CYP1A2 blue3 40946050,15
CYP2C9 red2 530585 100,30
CYP2C19 blue10 40946050,15
CYP2D6 blue 10 409460 100,30
CYP3A4 green2 485 53052,12
CYP3A4 red3 530 58550,10
Note: a. The linear range was determined by visual inspection; parameters for substrate concentration, wavelength and CYP450 concentration were provided by the kit
Table 2. IC50values of the ginsenosides and sapogenins against P450 enzymes.
Test compounds
IC50(mM) (%inhibition at 50 mM)a
CYP1A2 blueCYP2C9 redb
CYP2C19 blue CYP2D6 blueCYP3A4 green CYP3A4 red
Positive controlc
1.5 0.500.25 0.00760.49 0.97
.50 (25.2%)
.100 (20.6%)
.50 (29.1%)
.100 (10.1%)
.100 (4.4%)
.100 (31.3%)
.50 (17.6%)
.100 (5.0%)
.50 (49.4%) 99.768.8
.100 (38.3%)
.50 (34.8%)
.100 (27.7%)
.50 (18.1%)
.100 (12.6%)72.7
32.4 18.547.0 9.3 86.4 25.2
.100 (39.4%)30.9 49.9
.50 (20.3%)47.0 9.8
.50 (49.4%)30.5 9.1
.100 (28.1%)
.50 (38.0%)
.100 (8.8%)
.50 (44.2%)
.100 (4.3%)66.1
.100 (29.2%)
.50 (20.1%)
.100 (14.8%)
.50 (37.2%)
.100 (19.4%) 47.0
.100 (30.2%)
.50 (21.7%)
.100 (11.7%)
.50 (17.7%)
.100 (8.1%)
.50 (25.9%)9.3 43.1
.100 (17.1%)6.7 19.2
.50 (34.9%) 10.358.6
.100 (13.1%)31.6 46.9
.50 (18.9%) 7.4
.100 (22.8%)7.669.1
.50 (31.8%)25.6A.A.d
.100 (16.9%)8.543.9
.100 (4.8%) 7.526.5
.50 (12.6%)17.7
Note: a. The percent inhibition of ginsenosides against the respective P450 enzymes is shown when its IC50value is greater than the maximum concentration assayed.
b. The maximum concentration of ginsenosides evaluated for their effects on CYP2C9 and CYP2D6 were 50 mM due to the marked solvent effect of 1% methanol on
these two P450 enzymes (inhibition by 42.4% and 27.5%, respectively). When the final concentration of methanol was decreased to 0.5%, the solvent effects were
acceptable for these two enzymes (10.1% and 18.9%, respectively). 1% methanol had no inhibition against CYP1A2 and CYP3A4 and had an acceptable inhibitory effect
on CYP2C19 (9.7%).
c. Positive control compounds were a-naphthoflavone (for CYP1A2), sulfaphenazole (CYP2C9), miconazole nitrate salt (CYP2C19), quinidine (CYP2D6), and ketoconazole
(CYP3A4), respectively.
d. A.A.=apparent activation. 100 mM 25-OH-PPD and 25-OH-PPT increased the turnover of VividH CYP3A4 red by more than 100%.
SAR of Ginsenosides on P450s
PLoS ONE | www.plosone.org3 July 2008 | Volume 3 | Issue 7 | e2697
Page 4
(p,0.05). Rg3exerted relatively weak inhibitory effects against
VividH CYP3A4 green metabolism (Table 2). However, it potently
inhibited CYP2D6, for which all of the other ginseng compounds
had IC50values greater than 50 mM. Ginsenosides Rb1, Rb3, Rd,
Re, Rg2and Rg1weakly affected all five P450 enzymes, with the
exception of Rb1and C-K, which moderately inhibited CYP1A2
(Table 2). All of the sapogenins had weak inhibitory effects on
CYP1A2 and CYP2D6 (Table 2).
There is a SAR in the effects of ginsenosides on P450s
Considering that the same core structure shared by these
ginsenosides, the location, number and type of the glycosyl groups
covalently linked to the dammarane scaffold may account for the
their varying effects on P450 enzymes (Fig. 1A and Table 2). For
CYP2C9 and CYP2C19, the inhibition patterns of ginsenosides
are similar. Ginsenosides that do not have a glycosyl group on R2
and have two or fewer glycosyl groups on R1and R3as well as
sapogenins generally have moderate to potent effects on CYP2C9
and CYP2C19. As for CYP3A4 (green substrate), the inhibitory
activities of the ginsenosides and sapogenins decreased as the
number of glycosyl groups increased.
3D-SAR is shown in the effects of ginsenosides on VividH
CYP3A4 green metabolism
We applied the HipHop process from Catalyst software, which
compares diverse and highly active compounds to derive 3D
hypotheses based on common chemical features, without consid-
ering biological activities. The final training set consisting of 6
highly active compounds was submitted for pharmacophore
building. The best hypothesis (Hypo1), consisting of four features,
namely, one hydrogen-bond acceptor, one hydrophobic point, and
two hydrogen-bond donors (Fig. 2A). A representation of the
Figure 2. Shape-based pharmacophore model of the inhibition of VividH CYP3A4 green activity by ginsenosides. The model was
generated from the 3D structure of PPT and its activities against CYP3A4. PPT fitted into the model was shown in the figure. Blue represents the
shape space, black represents carbon atoms, red represents oxygen atoms, and white represents hydrogen atoms.
SAR of Ginsenosides on P450s
PLoS ONE | www.plosone.org4 July 2008 | Volume 3 | Issue 7 | e2697
Page 5
chemical features mapped onto representative studied compound
(PPT) is depicted in Fig. 2B. In this model, the hydrogen bond
acceptor seems to be mapped to the oxygen atom substituted at
atom C20, and the hydrophobic group fit well with the aliphatic
chain attached as side-chain to this moiety. The analysis shows
that hydroxyl substitutions at atom C3 and C12 are crucial.
Hydrogen-bond donors at these atomic positions will increase the
bioactivity. From Fig. 2B, it is evident that the hydroxyl group
substituted at atom C3 and C12 serves to be hydrogen-bond
donors (HD1 and HD2). Thus replacement with other substituent
group at oxygen atoms of C3-OH or C12-OH will result in
decreased potency.
The effects of the ginsenosides on CYP3A4 were
Considering potential influences of substrate selection on the
evaluation of the effects of the ginsenosides on the catalytic activity
of CYP3A4, another fluorescent probe, VividH CYP3A4 red
(Fig. 1B), was used. The assay conditions are also summarized in
Table 1. The solvent effect of methanol (1%) on CYP3A4 red
metabolism was negligible. The IC50value of ketoconazole on the
CYP3A4 red assay was 0.97 mM (Table 2). As for the ginsenosides
and sapogenins, the inhibition profiles using the red substrate and
green substrate were not consistent. For the same saponin, the
inhibition potency determined using the red substrate was greater
than using the green substrate (Table 2) (p,0.05). However, the
pattern was the opposite for sapogenins: the inhibition potency
was overestimated using the green substrate compared to the red
substrate (Table 2). Strikingly, 25-OH-PPD and 25-OH-PPT
activated the catalytic activity of CYP3A4 when using red
substrate. The representative influence profiles of PPD, 25-OH-
PPD, 25-OCH3-PPD and Rh2on CYP3A4 activities using either
red or green substrate are shown in Fig. 3. In the VividH red assay
(Fig. 3A), 25-OH-PPD potently activated CYP3A4 (about two-
fold) at a low concentration (10 mM). It was notable that at higher
concentrations 25-OH-PPD activated CYP3A4 red metabolism in
a saturated profile. At 10 mM, 25-OCH3-PPD weakly activated
CYP3A4 (about 20%), but weakly inhibited the enzyme at high
concentrations. PPD and Rh2 inhibited CYP3A4 in a dose-
dependent manner. However, the effect of Rh2(IC50=9.8 mM)
was more potent than PPD (IC50=43.1 mM) (p,0.01). In the
VividH green assay (Fig. 3B), however, all four tested compounds
inhibited CYP3A4 in a dose-dependent manner, with the potency
decreasingin theorder:
The effects of the ginsenosides and sapogenins on CYP3A4
were also substrate-dependent when using human liver micro-
somes and different conventional probes. CYP3A4-catalyzed
reactions (carbamazepine 10,11-epoxidation and nifedipine oxi-
dation) were used to evaluate the potential ginsenoside-drug
interactions. We employed high performance liquid chromatog-
raphy/tandem mass spectrometry (HPLC-MS-MS) analysis to
Figure 3. Effects of four different ginsenosides on the VividH CYP3A4 red assay (A) and green assay (B). Each point is the mean value of
triplicate samples, with error bars representing RSD values.
SAR of Ginsenosides on P450s
PLoS ONE | www.plosone.org5 July 2008 | Volume 3 | Issue 7 | e2697


text:
Toro Y Moi
The laid-back electronic pop artist on identity politics, not eating chicken wings, what pop music means to him, and his third album, Anything in Return.
By Larry Fitzmaurice , January 18, 2013
Photos by Andrew Paynter
Toro Y Moi's Chaz Bundick is sitting at the counter of Bed-Stuy bar Project Parlor, giggling and lightly blowing on a fresh wedge of pizza. "I like it when the cheese hardens a little," he says, by way of introduction. It's early November, and a few hours from now the bar will host an advance listening event of sorts for Bundick's third proper full-length, Anything in Return, with headphone-adorned listening stations accompanied by Bundick's original artwork. (Check out some of those drawings and listen to the album in full via Pitchfork Advance.) As we step out into the vaguely run-down neighborhood in search of a less distracting space to chat, I ask Bundick if he's familiar with the area. "I've been to Bed-Stuy once before," says the South Carolina native casually, surveying a street corner in between bites of his now-cooled slice. "I know that it's... unsafe." The evening is chilly and dark, and Bundick seems unfazed when we eventually settle on the front stoop of a residential building.
It's difficult to imagine anything that would truly ruffle the even-keeled 26-year-old. The deadpan complacency often attributed to Bundick and his peers' brand of devil-may-care electronic pop can be summarized by lyrics from his 2010 debut Causers of This: "I found a job/ I do it fine/ Not what I want/ But still I try." Now, after touring and putting out a string of releases that skip from glitch-hop to organic micro-funk to handmade space disco over the last three years, music is his livelihood. And he's still conflicted. "I want music to be a hobby for me, but it's a job now," he says, "so I'm going with the flow-- I only consider myself a musician because a label puts out my music."
A college grad with a B.A. in graphic design, Bundick hopes to return to his chosen field one day, either to obtain a graduate's degree or to become a teacher. But despite his professed lack of ambition, he's keeping on with the music thing for the time being. Anything in Return, meanwhile, is both his longest and most sonically fine-tuned LP yet-- it's his attempt at a "pop album that people can connect with lyrically." Currently based in Berkeley, Calif., he's also at work on material that could appear on the debut LP from his more dance-focused Les Sins project-- and he's looking to make another big sonic shift for the next Toro Y Moi record. "I just bought an acoustic guitar for my birthday, so it's really nice to play Ugly Casanova songs on it," he says. "I've gotten my chance to experiment with suave pop, but I really want to go back and play indie rock again."
"Identity politics are becoming less important since
culture's being blended into one big thing-- I look at
kids' Tumblrs and they're all into the same things."
Pitchfork: After growing up in South Carolina, why did you move to California?
Chaz Bundick: My girlfriend of eight years goes to grad school out there; one of the themes for this album is moving away from home for the first time. It's bittersweet, but I love it in Berkeley. I can see myself growing old there. It's a more liberal atmosphere. And parking's expensive, so I walk or ride my bike, which is good because my girlfriend's getting her PhD as an environmental engineer.
Pitchfork: Has her focus of study influenced how you live your life?
CB: For sure. Once you move in with your significant other, you have to become a combination of each other; I've adapted to her and she's adapted to me. She's really helped me to become a better person because she makes me think about things. Before, I wouldn't have an opinion on many things. You could ask me about a political issue or an environmental issue, and I wouldn't care. Now I actually care.
I recently stopped eating meat-- my birthday was two days ago, and I told myself that after my birthday, I'd try to practice that. Before, I would have a burger every once in a while, or some chicken wings. I'm going to miss chicken wings.
Pitchfork: How did these changes in your life-- new city, moving in with your girlfriend-- affect the general tone of Anything in Return?
CB: The album's about me trying to be a better person, especially now that I'm away from my friends and family. The only song that's not about that is "So Many Details". That and "Cake" are my versions of pop songs. I wrote "Cake" for my girlfriend so she can dance to it. She really loves Justin Bieber and The-Dream, and so do I.
Pitchfork: You said in an interview last year that it's an album of "sincere pop."
CB: I've always taken the word "pop" as its literal translation-- it's accessible, and that's why it's popular. For a while, the attitude was "radio sucks," but pop isn't shunned anymore. There's a lot of things that are pop-influenced, but I wouldn't call them pop-- I know Grizzly Bear call themselves pop, but they're more psychedelic folk-based with pop influences. A lot of my previous material was referencing more obscure artists, but this one was an experiment to see what would happen if I made a really poppy album. I already know I'm not going to make an album like this again.
Pitchfork: Why?
CB: I've seen artists turn into characters, and I don't want to become the "pop music guy." Pop music is awesome, but I like to keep changing it up. Electronic music is so weird because trends change so fast. I don't want to make something that sounds like [Causers of This] again. But I'm not worried about repeating myself-- I'm more worried that I'd just get bored. I like to challenge myself, to see if I can actually write a pop album that people can connect with lyrically. Musically, it's very accessible-- or, at least, I hope so.
Pitchfork: How do you feel about yourself as a lyricist?
CB: I'm so bad at lyrics. I'm always trying to get better. Sometimes, the song can restrict your lyrics-- if you're trying to make a poppy song, you don't want to sing something that sounds like it could be on an At the Drive-In song. Maybe one day I'll write my rock album so I can use more obscure references and just be weird. If the lyrics are too crazy, though, then it's not pop anymore.
Pitchfork: What was it like growing up as a mixed-race teenager in the South?
CB: It was weird. A lot of kids in elementary school would always be like, "What are you?" And I would go to Philippine-American Association parties, but I didn't feel like I fit in there, either; you don't know who to sit with or hang out with, which is how I ended up in the skater-musician crowd. But identity politics are becoming less important since culture's being blended into one big thing, especially in younger people. Kids are starting to dress the same, listen to the same music. I look at their Tumblrs and they're all into the same things.
Pitchfork: At the same time, though, indie culture still possesses a reputation for homogenous whiteness.
CB: I feel like that's starting to change. I see a lot of people of color in my fanbase and at all my shows, and it's really awesome. Ten years ago, guitar-based indie rock wasn't too popular with many young black kids. But now, especially with indie artists drawing from Top 40 R&B artists, the line is blurred.
Pitchfork: Odd Future's based in California, too, and you are friends with them.
CB: Yeah, Tyler and I try to meet up every once in awhile and work on music. I think he's a really smart kid, all of them are. Every once in a while, he'll text me about some crazy acid-jazz fusion funk group-- that's not a genre, but it will be soon-- and I'll be like, "Yeah dude, I'll check it out." They're all very open-minded. It's really cool to be around people that are younger than you who are really cool with being open about stuff.
Pitchfork: What's the story behind the album's cover?
CB: I knew I didn't want a photograph-- been there, done that. So I got a friend of mine, John Stortz, to do it. I gave him a photograph of me doing something with a bedsheet and my glasses, and he re-drew it. I wanted to use an image that could be symbolic, like that Paul McCartney photo where he has that quilt on with that hat-- something where the artist is doing something weird with their hands, like whenever you see Dennis Rodman holding his hands over some girl's boobs.
Pitchfork: What's your life like when you're on the road?
CB: I don't do intoxicants on tour too often. It slows me down mentally, and it feels like killing brain cells. I'm never drunk on the road, and since I've got to take care of my voice, smoke is definitely not allowed.
Pitchfork: For someone who would like to view musicianship as a hobby, that's an awfully professional attitude to take.
CB: That's just how I am. I could still be doing this 10 years from now, but right now I just want to enjoy the ride while it lasts. As a music listener, I'm becoming more and more ADD-- like, "Eh, I'm bored with this". So who knows how long I'll be playing music.
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text:
|Reviews for WARRIOR PRINCESS
| bigfan22 chapter 3 . 12/8/2013
Chapter was a little slow, but def entertaining. I can't wait to see Diana in Metropolis. Awesome story so far.
| bigfan22 chapter 2 . 12/8/2013
Another really great chapter. I loved how Clark was trying to keep Diana hidden from the Chloe and Lois. I'm a little confused...If Clark is 21, thn Chloe knows about his secret. I'm surprised he wasn't more honest with her about Diana. Fantastic chapter, and I can't wait to find out what happens next.
| bigfan22 chapter 1 . 12/8/2013
Wow...really good chapter. You've def captured my interest with Diana's arrival into smallville and with her meeting with Clark. Can't wait to see where this goes.
| Guest chapter 20 . 9/10/2013
ah ares, ever the cockblocker
| jon02 chapter 31 . 8/28/2013
Enjoyed the story.
| casema chapter 30 . 7/19/2013
Had to post here as I already reviewed chapter 31.
I can't tell you how many times I've read this story. The same goes for your others, especially the Words trilogy. They never fail to make me fall in love with this pairing. I want you to know that when the SMWW Fanfiction page doesn't get updated or the comics don't give us SMWW moments, I always come to your page to get my fix. Always.
| zArkham chapter 3 . 7/4/2013
I realize this story is complete, but I really think you need to go back and do some edits. Far too often there is no space between certain punctuation and the next word. Not sure how you wrote your original but I would think a quick Find/Replace could get it done quickly.
These errors really detract from a good story. I mean the first sentence in this chapter has no space between the commas and the following word!
| spiritedghost chapter 29 . 12/21/2012
One tends to apply mortal concepts to God's. Death is an inconvenience. By definition an IMMORTAL cannot be killed, if they could they would not be immortal. Like it or not, death is an inconvenience at best. Nice story by the way. (winks)
| casema chapter 31 . 12/2/2012
What an excellent story! I thought I had read all your stories...I don't know how I missed this one. I also enjoyed reading about the other league members.
| WonderGirl556 chapter 15 . 11/13/2012
I'm lovin' this story so far!
| Raven3182 chapter 31 . 9/25/2012
This is a good story. Not quite as polished as your later work, but still entertaining. Well done. I think you've converted me to the SM/WW ship. Thanks for writing!
| SilverReindeer chapter 31 . 4/17/2012
I've just added a number of your stories to my favorites' list of this new account, but WARRIOR PRINCESS is without a doubt the one story I like best.
Right now I don't have time to read any of your new stuff or re-read old fanfiction, but I certainly want to thank you for all those hours you spend slaving away, writing those exciting stories for our pleasure.
| Warden Valdr chapter 31 . 2/11/2012
I was intrigued by this story for starters. It was a great merging between smallville and justice league. I loved how you brought in a young Diana and the interaction between her and Clark was wonderful. This was a great story where you have combined my favourite characters into one well thought out and perfectly written piece of literature. As always you wrote the perfect romance between Clark x Diana and I applaud you for it escpeccially as this seems to be one of your earlier fics. So a great addition to the archives!
| Jason123456 chapter 23 . 2/9/2011
in some ways i can understand why clark his so slow in his way of doing things. Because if he was a more aggessive peron with his power level it would be very easy for him to step over a line. he could pish something someone does want and hurt than phyiscally or mentally. so he has to second guess himself to stay on the side of the angels.
| Star Dust of Ancient Novae chapter 31 . 9/14/2010


text:
@article {Lolekha:2010-12-01T00:00:00:1553-7250:541,
author = "Lolekha, Rangsima and Chunwimaleung, Suchin and Hansudewechakul, Rawiwan and Leawsrisook, Pimsiri and Prasitsuebsai, Wasana and Srisamang, Pramot and Wongsawat, Jurai and Faikratok, Worawan and Pattanasin, Sarika and Agins, Bruce D. and Fox, Kimberley K. and McConnell, Michelle S.",
title = "Pediatric HIVQUAL-T: Measuring and Improving the Quality of Pediatric HIV Care in Thailand, 2005–2007",
journal = "Joint Commission Journal on Quality and Patient Safety",
volume = "36",
number = "12",
year = "2010-12-01T00:00:00",
abstract = "Background: As increasing numbers of children initiate antiretroviral treatment (ART), a systematic process is needed to measure and improve pediatric HIV care quality.Methods: Pediatric HIVQUAL-T, a model for performance measurement and quality improvement (QI), was adapted from the U.S. HIVQUAL model by incorporating Thai national guidelines as standards. In each of five pilotsite hospitals in Thailand in 2005–2007, clinical data abstracted from patient records were used to identify priority areas for QI. Improvement strategies were designed by clinic teams in different care system areas, and indicators were remeasured in 2006 and 2007.Results: At the five hospitals, 1,119 HIV–infected children younger than 15 years of age received care in 2005, 1,183 in 2006, and 1,341 in 2007—of whom 460, 435, and 418, respectively, were selected for chart abstraction. Of the eligible children, ≥ 95% received clinical monitoring, annual CD4 count monitoring, ART, and adherence and growth assessments; 60%–90% received Pneumocystis jiroveci pneumonia (PCP) prophylaxis, tuberculosis (TB) screening, oral health assessments, and HIV disclosure. Indicators with a score ≤ 40% in 2005 but with significant improvement (p < .05) in 2006–2007 following QI activities were Mycobacterium avium complex (MAC) prophylaxis, and cytomegalovirus (CMV) retinitis and immunization screenings.Conclusions: Despite the promulgation of national guidelines, performance rates of some pediatric HIV indicators needed improvement. The pediatric HIVQUAL-T model facilitates use of hospital data for pediatric HIV care improvement and indicates that the U.S. HIVQUAL model is adaptable to developing countries.",
pages = "541-551",
url = "http://www.ingentaconnect.com/content/jcaho/jcjqs/2010/00000036/00000012/art00003"


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Top Stories
Western Nebraska moves into top spot in latest rankings October 7, 2015 Following the Cougars in top five are Southern Idaho, Indian Hills, Tyler and Northwest [read more]
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text:
STARmeterSEE RANK
Down 209,962 this week
Mohammed Hassan (I)
Mo Nassah is a young budding Hollywood artist set to take the world by storm. Born in London, England a Turkish Cypriot mother and Egyptian father, Mo is the only son and the youngest of three. Exposed to a multicultural lifestyle from birth and being raised at the heart of one of the worlds largest and most cosmopolitan cities, it was inevitable ... See full bio »
Born:Mohammed Hassan
in London, England, UK
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The Top Ten Places to Visit in South America
It is a land of natural exotic beauty that will leave you speechless, a land of mystery and great historic importance. South America springs to life with the tango, the Amazon River basin, glaciers, ancient ruins and whales that swim mere meters away from delighted visitors. This nearly forgotten continent houses an enormous abundance of natural and historical wonders. If you make a trip to the southern hemisphere, be sure to include these precious gems.
San Carlos de Bariloche, Argentina
With some of the most stunning mountain views in the world, San Carlos de Bariloche provides a unique mix of lakes, rivers and mountains unlike anyplace else on earth. For the outdoor enthusiast there is hiking, cycling, camping, climbing and world class skiing. You can find yourself secluded in a mountain forest or pampered in a European style ski lodge. In Bariloche, the choice is yours. Tip: avoid July as the town is flooded with vacationing students.
Bogota, Colombia
This is the heart of Colombia. With its vibrant citizens, this global city has great places to wine and dine, and the intriguing history of the city is irresistible. Visit the Gold Museum or the Church of San Francisco built in 1556. Don't forget to take a trip into the lush mountainous countryside. Mount Monserrate is especially breathtaking. On Sundays many streets are closed to create the Ciclovia, that is, bikes only are allowed. You can even rent bikes right from your hotel.


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SEND TO A FRIEND : Lindam Backseat Organiser
|Close x
|Close x
As the leading UK and European brand in child home safety, Lindam introduces a comprehensive range of Travel Safety Solutions. Combining safety and convenience, the range helps provide safety, comforts and convenience whilst on the go.
The Backseat Organiser by Lindam is a convenient storage organiser which simply secures to the back of the driver or passenger seat of your car. It has several compartments for storage of drinks, toys and snacks and will offer protection to the back of car seats.
This organiser clips onto the back of the seat easily and looks like it will be incredibly handy for the next few years! It has substantial sized pockets that are sturdy to hold a range of toys, wipes, cloths and drinks etc. It also clips onto the seat really easily and feels secure and strong. It has a bottom strap too which keeps it secured to the seat and stops it from flapping around. Will definitely be getting another if these for my husbands car!
Great purchase....
1 Sep 2014
The kids were super excited when these arrived. They were easy to install and good quality. I think they will last a long while. The cup shaped pockets held their water bottles well. I would only say that, in our car, the bottom pocket is too low and the kids tend to use the books that I slotted into them as a footrest and they are the largest slot and the only ones suitable for their larger books. So small books or small toys would be best and only small things in the bottom pocket. Of course, this only applies if one is using these as a place for kids to store their own things!
Sufficient for the price - good quality
27 Aug 2014
Really handy car tidy. As a first time mum my car needed to have a "back up" of everything for every eventuality and this car tidy really helps to keep it all in order. Lots of various sized pockets. Very easy to attached to car set (even though the backs of my front seats were wider than those in all the sample pictures of the item, it still fit and was easy to adjust). It is easy to clean off, sits quite tightly to the back of the chair using the bottom strap - unlike other tidies which tend to hang down and hinder an adult sitting in the seat it is in front of. Recommended
Really handy
First time mum
18 Feb 2014
Great item, perfect size. Different sized pockets allow you store almost anything baby related. I have spare wipes, nappies, cream, snacks, rattles, comforters, soft toys and a baby grow and still have a few pockets left. Easy to fit and held in place by a strap at the bottom to stop it flapping about. A great price too!
3 Feb 2014
Perfect, I might actually be able to keep my car clear of all the clutter having 2 children can bring.
I would recommend this product
22 Jan 2014


text:
The remains of 86 Jewish people sent to Nazi gas chambers in 1943 have been found at a forensic medicine institute in Strasbourg in France.
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2a>This deal2b> could be one of the most calamitous things to have happened in the Middle East for generations. While it slows Iran's progress to the bomb temporarily, it establishes a deeply flawed system of verification and emboldens the world's foremost state sponsor of terror — one that is openly committed to extinguishing the world's only Jewish state.
The agreement to 2a>curtail Iran's nuclear programme2b> has sharply divided opinion.


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In a departure from The Drum's usual Creative Department, where readers choose their...
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A new advertising expenditure forecast from Zenith Optimedia has predicted that in 2017 the internet will become the biggest advertising medium in 12 key markets with mobile contributing 70 per cent of all global adspend.
What inspires you outside of the agency walls?
Society as a whole has benefited from the evolution of mobile communications and the ability to...
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LinkedIn has revealed what it claims are the most influential brands in the UK with Ernst and Young emerging on top while BP, The Financial Times and The Economist also appeared in the top 10.
Microsoft has delivered a personal riposte to a Glasgow tweeter who pointed out that its recent ad campaign mentioning cricket was out of place in the city's East End.
From research recently conducted by The Agency Works, it has come to light that 66% of agencies in the UK are over-servicing. The Agency Works, a company which helps agency owners, MDs, and senior teams with the financial and operational aspects...
Brioche Pasquier is encouraging children to get active this summer as part of its new on-pack promotion.
The Telegraph Media Group has appointed Barry Wyse as the new director of commerce.


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Just thought I'd share some images that Scottish Opera had printed to promote their season. I cannot tell a lie, this post was scheduled to post a looooong time ago, and failed. So am popping it out now, because it's good to share!
No, they are not proper Tarot cards, nor are they my raison d'etre court cards, but I am sharing them here to remind you to keep your eyes open for Tarot-inspired artworks everywhere.
These items of ephemera are worth seeking out and procuring to add to your collection. One day they might be worth something to a collector. But in the meantime, they look excellent in little clip frames on the wall!
Monday, 28 September 2015
Wednesday, 16 September 2015
Marseille Sophistiqué | TPC Games | Review
So, I decided to hazard another foray into the Dark Arts of Imovie, this time with the Marseille Sophistiqué. The MS is a rather gorgeous little deck from those clever comic book artists at TPC Games.
|click on the photo to visit TPC Games
Before we get into the review, I know that there are a couple of glitchy things there in the video, but it takes about an hour for me to load up a video of this teeny tiny size to youtube. Fibre optic? I think we've got string here ...
As you can see from the photo, the box is a sturdy lift-top box that depicts 4 cards from the deck - a Major and a Minor, flanked by a King and Queen.
The cards themselves are 4 3/4" tall x 2 3/4 wide and printed on a linen-effect card which results in delightfully slippy shuffling.
It's a 78-card deck with Justice at VIII and La Force at XI. Yes, the titles are in French. It's a Marseille, so, yanno - get over it :) The deck is based (fairly faithfully, I think) on the Conver Marseille Tarot (1760s).
|The Unnamed Chappie
First up, this is a Tarot that has been created with GAMES in mind, not divination. There IS a LWB with the deck, but it is stuffed to the gunwales with rules for game playing and details of games, such as Baronetti and French Tarot. They do mention divination in an Appendix at the back of the LWB, but there are no card meanings included.
The first thing you'll notice are the non-traditional hues of the colour-scheme. If the primary colours of a traditional Marseille have you reaching for your sun-glasses, then this might be the deck for you. It's in muted shades of green, gold, blue and red, with white highlights. Very tasteful!
The colouring-in is deliberately quite scrappy - like an old deck - with lines clearly visible. However, although you can see the 'pencil marks', they colour outside of the lines just enough to be attractively arty and not so much that the untidy artwork shifts the gear-stick on your OCD into overdrive.
|Scribbly colouring. I like it.
It's a 78-card deck, with traditional Marseille pips. The suits are Deniers, Epees, Batons and Coupe. The Minors have coloured borders - Cups is red (more like pink, really), Deniers are gold, Swords blue and Batons are green. These borders also go around the Courts. The Majors don't have such a border.
Above are the four 10s of the deck, to illustrate the Minors. There is a X symbol for 10 in the top left, bottom right corners. Where the X coloured yellow is in the bottom right, the card is right-sides up. Where the yellow X is in the upper left, it is upside down.
The back (shown at the end of the video above) is suitable for reversals.
So, what do I think? It's a nice size for handling and it shuffles beautifully. It's easy to distinguish Swords from Wands thanks to the colours selected. The muted, almost sugar almond, shades are delicious. And of course, the design is a proven classic.
I think this deck is gorgeous and a worthy addition to anyone's collection.
Do you have the Marseille Sophistiqué - what do you think of it?
Do you use it or just admire the artwork?
How are you at reading with unillustrated pips?
Want more games to play with it?
Thursday, 3 September 2015
Tarot Thrones is Supporting Syrian Refugees
No court card humour from me today. And believe me, be glad that there is no photograph to illustrate today's blog post.
I'm appalled by the humanitarian crisis that we are seeing as a result of Syrians fleeing their homes. The newspaper headlines would break your heart.
So, TABI has set up a justgiving page to show the world that Tarot people CARE about what's happening to these people in their time of crisis.
No more drowned children.
Let's put a stop to it.
You can make a donation through that portal.
You can take this code and put it as a button on to your website or your blog and also support us that way.
To add to your blogger blog, select the 'add html' widget in 'layout' and drop the code in, save. That's it.
I'm appalled by the humanitarian crisis that we are seeing as a result of Syrians fleeing their homes. The newspaper headlines would break your heart.
So, TABI has set up a justgiving page to show the world that Tarot people CARE about what's happening to these people in their time of crisis.
No more drowned children.
Let's put a stop to it.
You can make a donation through that portal.
You can take this code and put it as a button on to your website or your blog and also support us that way.
To add to your blogger blog, select the 'add html' widget in 'layout' and drop the code in, save. That's it.

Thank you
Monday, 17 August 2015
Page of Pentacles | Baking | Focaccia di Recco
|Page of Pentacles
on his way to Masterchef
The Page of Pentacles shows us the beginner in practical matters.
I am definitely this Page when it comes to cooking. Most efforts turn out to be only fit for the inside of the swing bin - except my lasagna. My lasagna is TO DIE FOR. Well, hopefully not DIE …. but you get the general idea.
Wednesday, 12 August 2015
The Alchemical Tarot | Robert Place |4th Edition
|The Alchemical Tarot
on the Throne!
This is the 4th Edition of this deck and it has been funded via an Indigogo campaign.
We've got four families - Staffs, Swords, Vessels and Coins; nice and traditional.
Each family member sports their name and also the elemental glyph associated with that suit. The first thing that you will notice about the courts in the Alchemical Tarot is that the Pages have been replaced with the rank of Lady and the second thing is that the King is not a figure but a creature.
Let's take a closer look ...
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And they're off ! A Three Day Report !
... was in the day of the square riggers who once caught in a westerly gale were basically doomed, they could only go one way - on to the rocks. And believe me there are plenty of them in the normal sailing areas of France and Northern Spain especially on the coasts around Biscay. We had waited for a favourable weather window, we kept checking half a dozen sites over a week, checking, doubling checking and treble checking each one everyday for ...
Last Day in Camaret
... to rush it - were hoping we made the right choice. I checked the engines and repaired a cleat which had started to come loose with all the stress put on it when we were on the outer harbour breakwater. Tracey did her washing, got the side panels down off the canopy ready for a quick getaway in the morning and we bought the last of our groceries which we'll need for next few days. The crossing is approx 315 miles harbour to harbour and we ...
New Mooring
... good job we moved when we did. Even the Naval Rescue ship has taken refuge in the lee of the bay. I had a hot shower to get rid of the diesel smell and then got dressed up (well shirt and jeans) for the first time in weeks - why ?? I just felt like it. And after a hearty dinner of Chilli con Carne, French Bread and a bottle of Red we popped into town for a hour. We met up with Ted and Chris another couple we ...
The dreaded outer Breakwater
... thing but it is nice to know people are also crossing at the same time. Tomorrow we will start getting the boat ready, fuelling her up, filling the tanks, doing engine and sail checks etc Tonight it's another night on the outside because there are no other berths free to get at, we keep trying all combinations on the ropes but none are working how we would like them too, Looks like another sleepless ...
Full Day Foraging
... clams and cockles went into the Thai Soup I made for dinner and went down well, the lob worms, crab and mussels we used for bait fishing off the back of the boat but the motion is that bad you wouldn't know if you had a bite or not so no fish today. We had our nightly jolly into town to check weather (again) emails etc and came back to watch a Dvd. I was right about a poor nights sleep - I was forever up and down checking the mooring lines - We are moving back inside tomorrow for ...


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Investigating the meaning behind the keywords and searcher intent leads us to some valuable insight into human behavior.
Keyword research is, as I have said before, foundational to any Internet marketing campaign. Learning which keywords will drive the right traffic is very important. When we spend time researching keywords it is usually in the context of simply finding keywords for our campaigns. However, investigating the meaning behind the keywords and searcher intent leads us to some valuable insight into human behavior. Some call this keyword forensics.
For all of you CSI fans, you have probably heard the term "forensics." Instead of following fingerprints to solve a crime, we are using keyword research tools and investigative skills to learn more about the "what," "why," and "how" of our target audience. In essence, we are studying search trends and behavior to learn more about searcher intent so we can lead them to and then serve them the content they are looking for.
Using Keyword Research to Learn Human Behavior
People have flocked to the Internet and use it as a tool for many reasons. Your job is to get a better understanding of their true purpose. So as you conduct your keyword research, think in terms of "human behavior" not just a bunch of statistics about the keywords. However, look at the statistics and interpret the deeper meaning. What is the purpose behind the search? This is the kind of mindset you should start getting accustomed to.
So start training your mind to look beyond keyword popularity and begin looking at trends and any insights to user intent. For instance, a simple search on the word "full suspension mountain bike" showed there were about 18,000 global monthly searches.
However, if you look at the use of the word over a period of time you get a deeper understanding. So I looked it up using Google Insights and found that the volume of searching for this phrase was higher in the spring and summer. If I were to develop a campaign around this keyword I would consider increasing my PPC activity around those months. Additionally, I would make sure my website had highly relevant content to support this keyword.
If you use a Web analytics tool, and you should, you will find more keyword trend information as it relates to your website. Learn which keywords are bringing in the most traffic, which is converting the most. What behavioral path are people taking as they navigate through your site. Is it the right path? Then based on what you learn make any course corrections necessary to make the experience that much better.
Interpreting Searcher Intent
Keyword forensics takes us beyond what we think the right keyword phrases should be and forces us to look at the searcher and their motivations, their intent, and desires. For example, what can we learn from a person who searches for "digital camera"?
First, they might be in the market for purchasing a digital camera. But because of the general nature of the keyword they probably aren't ready to purchase one. I would guess that they are in the beginning of their buying cycle. Within your industry or company you might have access to research about the time it takes from initial research to making a purchase. This may be helpful as you plan your campaigns in this case.
Now, contrast this with a search for "Canon EOS 5D Mark III." What can we infer from this keyword phrase? In this case, the searcher knows exactly what they are looking for. They have likely finished their research and found the specific model they have an interest in. It is probably safe to assume they are ready to make a purchase and they are now looking for the best price.
So what can we do with this information? Well, the more you can learn about what searchers are looking for you can try to anticipate their needs and set up your campaign accordingly. Those campaigns should be designed to take the searcher directly to the page on your site that will satisfy their need. By doing this you have created a highly relevant campaign that has a higher probability of leading to a conversion.
Learning the use of Trigger Words to Explore Behavior
There are certain keywords that lead a searcher to take action. These "trigger" words can provide insight into intent. Some of these keywords like: "learn," "information," or "how to," help us learn that the intent is to gather information. Additionally, keywords like "free," "cheap," or "savings" tell us that these searchers are very price conscious. If you have a premium or a luxury product you will want to use negative keywords to avoid this kind of traffic to your site.
As you conduct your keyword research always look for clues for the purpose behind it. Identify the root word, then look at the descriptive prefix or suffix words. What extra meaning do they tell? As you get used to the idea of looking for deeper meaning behind the keywords you use in your campaign, you will find that your campaigns will grow to a new level. The more you know about human behavior, the better you can prescribe the right content for them and how they come to find it.
Ron was president/CEO of Symetri Internet Marketing, which provides strategic SEM consulting and training. Ron was actively involved in the SEM community and spoke and trained at conferences and seminars. Ron also served on the Board of Directors for SEMPO and was one of the authors for the SEMPO Institute Fundamentals and Advanced courses.
Ron also published a book called Keyword Intelligence: Keyword Research for Search Social and Beyond. This book outlines various methods and tips for conducting keyword research but more importantly outlines many ways to use keyword research for social media, site design, content development and marketing, and even traditional marketing and branding.
Ron passed away on June 30, 2012.
October 21-22, 2015
November 17-19, 2015
November 25-26, 2015
April 11-13, 2016
Spring 2016
US Consumer Device Preference Report
Traditionally desktops have shown to convert better than mobile devices however, 2015 might be a tipping point for mobile conversions! Download this report to find why mobile users are more important then ever.
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October 13, 2015
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text: Nov 27, 2012 21:25 Rubble cleanup stretching resources Rubble cleanup stretching resources Associated Press photo by Wayne Parry -- A crane sits atop a pile of storm debris in a parking lot in Point Pleasant Beach, N.J. Superstorm Sandy created tons of debris that towns in New York and New Jersey are still struggling to dispose of weeks later. An American flag blows in the breeze in front of one of the largest pils of storm debris at the Jersey shore in Long Branch N.J. in this Nov. 15, 2012 photo. Superstorm Sandy created tons of debris that towns in New York and New Jersey are still struggling to dispose of weeks later. Three weeks in, the round-the clock effort to remove storm rubble has strained the resources of sanitation departments and landfill operators, and caused heartaches and headaches for thousands of families. (AP Photo/Wayne Parry) Backhoe operator Keith Henry levels a storm-damaged home in the Breezy Point section of the Queens borough of New York, Tuesday, Nov. 20, 2012. The splintered plywood, mangled appliances and sodden sheetrock, as well as shreds of clothing and family photos will be added to the increasing piles of rubble being cleared in New York as the cleanup from Superstorm Sandy continues. (AP Photo/Mark Lennihan) DAVID B. CARUSO| Associated Press Comments Get The Advocate in your inbox Subscribe


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Red Hat Enters Virtualization Support Agreement with Microsoft
U.S. Linux vendor Red Hat has entered a cooperation agreement with Microsoft in technical support of server virtualization.
Customers running Windows Server and Red Hat Enterprise Linux virtualization now have joint technical support from the two companies. Red Hat has committed to participate in Microsoft's Server Virtualization Validation Program. Reciprocally, Microsoft has joined Red Hat's Virtualization Certification Program and will be listed on the Red Hat Certification List once Microsoft completes the certification process.
The newly formed partners emphasize that the arrangement is in no way like Microsoft's partnering with Novell. The Microsoft-Novell deal goes much deeper and involves technical collaboration, licensing and patent protection.
For Microsoft, Red Hat still remains a competing platform provider despite the support arrangement. In fact, Microsoft's GM of virtualization Mike Neil emphasizes that "these agreements do not include any patent or other IP licensing rights." Both companies also assure customers that their cooperation has no effect on their previous agreements with virtualization specialist VMware.
As a first step, the two companies will enter each other's validation phases, results of which will be posted to their respective websites during the course of the year, for Red Hat and Microsoft.
Issue 180/2015
Buy this issue as a PDF
Dyreza Malware is Back
Powerful man-in-the-middle attack is now targeting online shopping.
Kernel Developer Matthew Garrett Forks the Linux Kernel
Another high-profile coder says the kernel team needs a kinder, gentler culture.
Bugzilla Bug
Bug database has a bug of its own that could allow an intruder to create an unauthorized account.
US Launches New Strategy for Broadband Access
Report focuses federal resources on achieving universal Internet access.
RC4 Finally Gets the Fork
Leading browser makers say "no" to porous encryption algorithm
IBM Says TOR Network a Vehicle for Ransomware
Report from the X-Force group says attackers are using TOR to hide their crimes
Mozilla Announces new Firefox API
Future Firefox extensions will be compatible with Chrome.
Weird Security Flaw Affected Intel Chips for 16 Years
Better read this if you bought your computer before 2011
OpenSSH 7.0 Secure Shell Arrives
Users should upgrade to the new version as soon as possible
Qemu Flaw Lets the Guest Escape
Xen project announces a privilege escalation problem for Qemu host systems


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Browse thai restaurants in Derby featuring photos, videos, vouchers and thai restaurants reviews to help you choose the right local thai restaurants for you.
Why not list your thai restaurants business on Derby Telegraph?
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StartUpHire is the place to find jobs at Greenville startups. Review the list of Greenville career opportunities to the left. These Greenville, SC jobs at startups represent some of the most rewarding careers available.
You can refine your job search for Greenville career opportunities by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options.
Don't see the employment opportunity you're looking for? Check back soon for more startup jobs in Greenville, or sign up for an email alert (link below) to receive periodic updates on new start up jobs in Greenville, SC.
Demand for Startup Professionals in Greenville, SC
Startup Jobs in Minneapolis, MN
Startup Jobs in Research Triangle
Site : Not Specified Location : Piedmont SC US 29611 Education : High School / GED Category : Professional Job Description : Immediate Need BHI Energy is currently accepting resumes for an I&C Instructor. The qualified Instructor will have experience teaching within a classroom9/15/2015 Piedmont, SC Save This Job
City: Simpsonville State: South Carolina Shift: 1st Shift Job Description Storeroom Solutions, Inc. (SSI) is the fastest growing independent provider of MRO/indirect materials management services in North America. Currently, we support close to 200 customer sites in the US,9/7/2015 Simpsonville, SC Save This Job
Date Posted8/21/2015 Job TypeContract Full-Time Position Id22409 Job Description Fieldglass: Job Posting Fieldglass: Job Posting Excellent Communication skills to interact with IT, offshore and Business departments. ? Must to have are: Solid hands on technical skills on RESTful8/31/2015 Greenville, SC Save This Job
Site : Not Specified Location : Piedmont SC US 29673 Education : High School / GED Category : Mechanical Job Description : Hydro/Gas/Steam Turbine Supervisor/Foremen?s needed - BHI Energy has a immediate openings for Supervisor/Foremen?s with 8 years minimum leadership experience8/16/2015 Piedmont, SC Save This Job
Site : Not Specified Location : Piedmont SC US 29673 Education : High School / GED Category : Mechanical Job Description : Hydro/Gas/Steam Turbine millwrights needed - BHI Energy has a immediate openings for a millwrights with 3 years minimum experience in on site Scheduled /8/16/2015 Piedmont, SC Save This Job
The Market Access Director for Government and Managed Markets supports and provides input into the vision, strategy, analysis, tactical implementation plans and opportunity for securing reimbursement with commercial and government payors for Juxtapid. The ability to work in a8/16/2015 Greenville, SC Save This Job


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stitching memories — huger embroidery
There's nothing I love more than meaningful gifts that tell stories and preserve memories. That's why I love the work the work of Richmond's own Huger Embroidery. Of course there's the classic monogram, and Huger Embroidery does that very well, but their work capturing photographs, original artwork and drawings in thread and fabric is so incredibly fascinating and original! Above, our sweet clients' engagement is captured on a pillow, while below, family pets, children's drawings, invitations, photographs, and the like are stitched into heirlooms. I think I have Christmas gifts all figured out this year months ahead of schedule!
Happy new year!
photo by katie stoops
details make the design
martha stewart weddings top wedding planners
We're just so over the moon about Martha Stewart Weddings' announcement of the top wedding planners of 2014 (featured in the anniversary issue on newsstands this week); and we're beyond thrilled to share the honor with friends Calder Clark, of Calder Clark Designs, and Maria & Kelly, of Ritzy Bee, as well as other luminaries in our industry whose work we've long admired. 2014 has been incredible. Merry Christmas, friends! xox
Flower Magazine
Thrilled to see Megan and Will's wedding in the current issue of Flower Magazine. We adore this couple and couldn't have asked for a better team to work with us. To see more, pick up the current issue of Flower or click over to the online version of the story here.
Southern Hospitality
In addition to styling Janie Medley's lovely feature in the latest Southern Weddings Magazine, the SW girls were kind enough to ask me to contribute to a story called "35 tips for a wedding full of southern hospitality." Naturally, I wrote about something that's near and dear to my heart — timing. No matter how beautiful the details, how sumptuous the linens, how striking the flowers, a thoughtfully crafted event day agenda is the foundation of your event; anticipating how your guests will experience each moment of your wedding day and crafting an experience with them in mind is one of the most generous expressions of hospitality!
Bouquets inspired by southern states we call home…
It was such a pleasure to work on this story last spring with Patricia Lyons and Janie Medley for Southern Weddings Magazine's current issue. We were tasked with bringing the personality and charm of six southern states to life in bouquets. For instance, while Tennessee was a bit wild and folk-inspired, in homage to its country music roots, Florida centered on warm, citrus tropical inspired elements. Pick up the latest issue to see the full story!
floral design by Janie Medley // photography by Patricia Lyons // styling by Courtney Spencer of Merriment Events
Flowers for Ave 42's holiday pop-up style studio
I was delighted to put together some pretty flowers in blush and gray tones for Ave 42 Design's pop up shop at short pump mall. Ave 42's pop up style studio, offering blow-outs, up-dos and makeup, will be in its temporary location, in between nordstrom and south moon under, through the holidays, where you can get ready to "party pretty!"
Sneak Peek: Martha Stewart Real Weddings Special Issue
If you haven't had a chance to flip through the pages of Martha Stewart's Real Weddings Special Issue yet, you're in for a treat! From new "good things" (always a favorite of mine!), to enchanting floral design, to real wedding features, the special issue, released just twice a year, is rich with inspiration.
I'm happy to share a sneak peek of one of the weddings featured in this issue —Allison and Tyler's mediterranean revival affair in Florida. With its pretty peach color palette and a mesmerizing love story (Allison and Tyler met in middle school!), this wedding is the stuff of dreams.
Guided by her father's philosophy "the more, the merrier," more than 370 guests feted the couple, while 14 bridesmaids, wearing neutral and blush-colored gowns, accompanied Allison at the altar, and three priests officiated the ceremony. To see all of the pretty details and read more of the story, be sure to pick up a copy of the Real Weddings Special Issue!
Photos by Tory Williams, courtesy Martha Stewart Weddings
a spring wedding at tuckahoe plantation
We were so honored to work with M + W on their spring wedding at the venerable and ever beautiful Tuckahoe Plantation, captured here by Katie Stoops. Our sweet clients entertained nearly 300 guests under a sperry sailcloth tent on a perfect spring evening, following a Catholic ceremony at a church nearby. The colors were soft and whispery shades of pale, buttercup yellow, mint green and peach. We showered out of town guests with local indulgences — hardywood beer, virginia cookies (with a heart piped over Richmond!), lamplighter coffee. All in all it was a picture perfect day, don't you think? Could the perfect weather have had something to do with the bottle of bourbon the couple buried at Tuckahoe a month to the day before saying I do? We'd like to think so.
To see more from this wedding, please visit Snippet & Ink.