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Auto Repair in Lexington
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Carmine's Import Service can take care of all your service and repair needs from oil changes to major repairs, and you have the confidence of taking your car to a Bosch Authorized Service Center.
Our staff includes two ASE Certified Master Technicians. We specialize in European Imports, (BMW Service, Mercedes Service, Audi Service, Porsche Service, Land Rover Service, Range Rover Service, Fiat Service, Jaguar Service, Volvo Service, Volkswagen Service, SMART Service, MINI Service, and Saab Service),however we can take care of all of your car needs no matter the make.
At Carmine's Import Service, our #1 goal is 100% customer satisfaction and we place a lot of emphasis on strong customer service, high quality workmanship and expert advice so that you minimize your maintenance expenses. You may also take advantage of our Night/Early Bird Drop Service Box. We also have shuttle service and loaner cars available if your vehicle will be with us for an extended stay.
We offer up to a 3 Year / 36,000 Mile Warranty on parts and labor for most service. We promise to provide you with the highest quality of work and customer service you will find in the Piedmont Triad; guaranteed!
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Welcome to Ilderton Dodge Chrysler Jeep where WE DELIVER outstanding customer service, selection, value, respect , follow-up, in fact WE DELIVER a promise to give you the best automobile dealership experience you will ever have. Here at Ilderton Dodge Chrysler Jeep Ram we have a great selection of new Dodge, Chrysler, Jeep & Ram vehicles as well as a large selection of used and Certified Pre-Owned vehicles. Here at Ilderton we are considered the Crown Jewel of Chrysler Dodge Jeep Ram dealerships, selling over 2,000 new cars a year. That makes us the "North Point" leader for all of your car needs in Greensboro, Winston Salem and Kernersville.
There are 35 auto service shops and mechanics in Lexington. Edit searchSee other auto repair shops and dealerships
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Celastrus paniculatus, also known as Intellect Tree Seed and Malkangani.
This shrub, native to India, has been known as a mild stimulant but most importantly as a powerful nootropic. Famed medicinally for its effects on the brain... sharpening the memory and increasing intellect.
We also have organic, high quality cold pressed oil available HERE!
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Artex Electric Service First Pro
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Business Directory
Ministry donates blankets to shelter residents
By: Rhonda Morrow - Texarkana Gazette
Submitted photo • Becoming Free Outreach Ministry members recently donated nearly four dozen blankets to residents at the Randy Sams' Outreach Shelter in memory of the victims of the Sandy Hook shooting. Pictured from left are Shelia Ross, Cheroke Brown, Kenetha Nelson and Sallie Datsun....
Members of Becoming Free Outreach Ministry found another way to meet both spiritual and physical needs during the holiday season.
The ministry, a nonprofit organization sponsored by the... Published: 01/12/2013
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Kidrobot has teamed up with J★RYU and Vampy for some incredible Kidrobot Store (and web!) customs just for you!
Our plus sized friend gets quick transformation to his noggin and is ready to serve your favorite holiday refreshment.
Our favorite geek boutique, Uber Cool Stuff of London, Ontario, is hosting their first custom and DIY toy exhibit. The show, set to open November 17th, features custom work by Brad Biederman, Gabe Griffiths and Jordan Gosselin, plus work from independent toy designers throughout Ontario.
A high five and lots of love to everyone who contributed to our Micro MUNNYWORLD Instagram Contest! We are finding lots of fun things to do with Micro MUNNYWORLD, and it was really rad to know our fans are too.
The fine folks at Monkey See Monkey Do in Austin, TX are hosting a Toy Decorating MUNNY Party on November 13 at 7pm. Every DIY toy purchase enters you to win one of five 4″ MUNNYWORLD figures designed by local artists GabrielLewis.com, Smudge Studios Austin, Ella Minnow P. and one by the Money See […]
On November 18, our friends at Silver Snail Comics will be hosting their first MUNNYWORLD Custom Party and Contest from 11am to 5pm.
84pages and Berk Visual battle it out on two Mega MUNNYs at Kidrobot Boulder November 3.


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Lets Talk It Out Not Act It Out
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Barrio Vinueva, 76, 39590 Quijas, Spain
Quijas, Spain - 681 m from city centre see map
Some of the delightful rooms to be found on the ground floor of this 1500m2 "indiano casona", built in 1872, are a sitting room with...
Some of the delightful rooms to be found on the ground floor of this 1500m2 "indiano casona", built in 1872, are a sitting room with fireplace, another sitting room with a small library containing books about Cantabria, and a glass-roofed patio. On the first floor furniture made from mahogany and from the modernist period and on the second floor lofted rooms with their original wooden beams creating a unique ambiance. Beyond the glass-roofed patio are 5 more rooms, two of which have facilities for the disabled. A beautiful garden planted with indigenous trees surrounds our "Casona" making it the perfect place to relax all year round. We have a total of 22 rooms, including 2 single rooms and a suite with sitting room. All the rooms are en-suite (two have hydromassage baths) and have heating, telephone and television and some adapted for the disabled. There is also private parking. We have connection wifi in rooms and halls. Breakfast at the Casona includes natural fruit juice, regional specialities, a fruit basket, olive oil, cheeses and cured meats. We have two large reception rooms, one with fireplace and the other a reading room (with books about the region), a dining-room and a central glass-roofed patio of 140m2 which together with an adjoining reception room makes the ideal location for weddings and business gatherings.
From the airport, take the A-8 motorway, exit 238. Near to Santillana del Mar, Comillas and the Saja Nature Reserve, as well as the beaches at Cobreces and San Vicente de la Barquera, and just 20 minutes from Santander.
Barrio de La Venta, 69, Quijas, Spain
Quijas, Spain - 215 m from city centre see map
Casona del S.XIX cuidadosamente rehabilitada, a 15 Km. de la Reserva Natural del Saja y a 10 Km. de la Cuevas de Altamira, a 60 Km. de...
Casona del S.XIX cuidadosamente rehabilitada, a 15 Km. de la Reserva Natural del Saja y a 10 Km. de la Cuevas de Altamira, a 60 Km. de los Picos de Europa y cerca del mar.
22 habitaciones dobles, una de ellas acondicionada para minusválidos, con baño, teléfono, secador de pelo, TV, calefacción e hilo musical.
Restaurante, Comedor (desayunos), 2 salones (uno con dvd), servicio de cafetería hasta las 23:00 h. y disponibilidad de cuna gratis.
Casona del S.XIX cuidadosamente rehabilitada, a 15 Km. de la Reserva Natural del Saja y a 10 Km. de la Cuevas de Altamira, a 60 Km. de los Picos de Europa y cerca del mar.
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Our search engine enables you to book any type of hotel in the city of Quijas, allowing you to select the best offers for either luxury hotels or a wide range of budget hotels and hostels in Quijas. In order to do this, just enter the name of the city, choose the arrival and departure dates, select the number of occupants and type of room, and click on find hotels. As an extra option, you can also search by category and/or accommodation regime, from 'accommodation only' to 'all-inclusive'.
Once you have made the search for a hotel in Quijas we will show you an extensive list of offers, ordered in accordance with our criteria. Obviously the results can also be ordered by name, category, approximate price or based on the evaluations by our clients. We also provide a small description of the accommodation in Quijas that you selected, so that you can decide whether or not it responds to your expectations.
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The detailed information on each hotel includes its address, whether it has a minibar service, its telephone number and whether it offers free services.
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stay away from my boy!
This great custom product in black from our department Women and T-Shirt category can be printed just for you in the size and style you like. The design stay away from my boy! was created by clothing69 and uploaded to Spreadshirt for you to have printed on a T-Shirt. Next to a host of other great customized designs, you can find this stay away from my boy! design in Spreadshirt's Couples category. If you are interested in topics like His or couple, then you'll love stay away from my boy! designs by clothing69. Spreadshirt also offers a huge selection of custom t-shirts, hoodies and accessories for the category Couples as well as top forever clothing. clothing69's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your destination for great designs of all kinds – whether it's His, couple or forever. We are sure that you will find something nice in our shop, there are many amazing custom Couples t-shirts, hoodies, or accessories for you to find! Tags: Design ID: 12324693
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This figure-flattering, slim fit t-shirt is soft, stylish and above all comfortable. This is the one you don't let your girlfriends borrow, because you'll never see it again. It's perfect with jeans, khakis, leggings or pretty much any other bottom and it's great for layering.
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"Over the past five years, UCL has performed pioneering research in image registration and fusion technology that has led to significant advances in the clinical validation and adoption of focal HIFU," said Mike Klein , CEO for SonaCare Medical. "We are proud to work together to expand access to targeted treatment for prostate cancer through the integration of SmartTarget software into SonaCare Medical's HIFU industry-leading HIFU systems."
About UCL Business PLC
UCLB is a leading technology transfer company that supports and commercialises research and innovations arising from UCL, one of the UK's top research-led universities. UCLB has a successful track record and a strong reputation for identifying and protecting promising new technologies and innovations from UCL academics. UCLB has a strong track record in commercialising medical technologies and provides technology transfer services to UCL's associated hospitals; University College London Hospitals, Moorfields Eye Hospital, Great Ormond Street Hospital for Children and the Royal Free London Hospital. It invests directly in development projects to maximise the potential of the research and manages the commercialisation process of technologies from laboratory to market.
UCLB supports UCL's Grand Challenges of increasing UCL's positive impact on and contribution to Global Health, Sustainable Cities, Intercultural Interaction and Human Wellbeing.
For further information, please visit www.uclb.com
About UCL (University College London)
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architect
|SOURCE SonaCare Medical
Copyright©2012 PR Newswire.
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Location: Grove Park Theatre
Date: 4th – 13th Septmeber
Time: 07.30
Details: The setting is a retirement home for musicians. Three elderly former opera-singers, who often worked together, are sitting out on the terrace. Reginald is quietly reading a serious book, but the jovial Wilfred is chuckling about sex, as he regards Cissy lying back and listening to music through her headphones.
They are about to be joined by newcomer Jean, a major star in her day, and to whom Reginald was once unhappily married.
Is there any chance that these four will ever sing together again? A gala concert is about to take place at the retirement home to celebrate Verdi's birthday.
Prices : £7.50 – £9.50
Contact : www.groveparktheatre.co.uk
Image :
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|Publication number
|Publication type
|Application number
|Publication date
|Feb 1, 2005
|Filing date
|Jan 9, 2003
|Priority date
|Jun 10, 1999
|Fee status
|Also published as
|Publication number
|Harold H. Hoium, Stephen J. Ryan, Marek Malik
|Original Assignee
|Harbinger Medical, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (5), Referenced by (5), Classifications (6), Legal Events (8)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation of application Ser. No. 09/590,965, filed Jun. 9, 2000 now U.S. Pat. No. 6,512,945, entitled, METHOD OF NONINVASIVELY DETERMINING A PATIENT'S SUSCEPTIBILITY TO ARRHYTHMIA, which claims priority under 35 U.S.C. �119(e), to previously filed U.S. Provisional Application No. 60/191,029, filed Mar. 21, 2000, the subject matter of which is incorporated herein by reference, and claims benefit of Ser. No. 60/138,497 filed Jun. 10, 1999 and claims benefit of Ser. No. 60/138,439 filed in Jun. 10, 1999.
The invention relates to the detection of patients' susceptibility to arrhythmias and, more particularly, to various techniques for improving the detection of signals to achieve this goal.
There are various devices known in the art for monitoring heart function. Many of these devices typically function by analyzing signals such as an electrocardiogram signal, which can be representative of heart function.
There is a need to identify patients at high risk for life-threatening arrhythmias.
Various means have been proposed for detecting patient susceptibility to arrhythmias. U.S. Pat. No. 5,117,834 discloses one method by which pulses of electromagnetic energy are injected into a patient and the changes in the patient's electrocardiographic signals caused by the injection are recorded. U.S. Pat. No. 5,351,687 is similar in concept to U.S. Pat. No. 5,117,834, but it describes use of a magnet sensor for use in detecting the cardiographic signals. U.S. Pat. No. 5,555,888 discloses various means for adapting and automatically facilitating the assessment techniques and means similar to that shown in the above patents for determining patient susceptibility to arrhythmias.
Other techniques which are used to analyze cardiac signals for somewhat similar purposes include those known as t-wave alternans and signal-averaged electrocardiograms. Each of these techniques is limited in its application and utility by various factors which are overcome through use of the below described inventions.
The present invention provides a system and method of determining, through noninvasive means, a patient's susceptibility to arrhythmia. More specifically, this invention comprises various improvements to known innovations for optimizing detection of a patient's susceptibility to arrhythmias. This invention embodies numerous software and sequence improvements for applying this basic technology.
Another purpose of this invention is to provide hardware and software analysis means for detecting and amplifying relevant signals.
Another purpose of this invention is to provide for improved performance lead sets and the software to promote ease of attachment and removal from the patient and ease of connection of the lead system to the hardware.
A further object of this invention is to provide new combinations of electrode placement and use to promote better arrhythmia susceptibility diagnosis.
A further object of this invention is to provide a reduction in the size of necessary components to allow for hand-held system dimensions.
A further object of this invention is to provide a means for distinguishing between the signals from the X, Y, and Z directions as well as previously unused directional components of very low-level signal data.
Another object of this invention is to supply means for displaying of patient's waveforms and other data derived from the detected signals, as well as to provide various interfaces to communicate the data between the patient and physician or health care professional.
It is a further object of this invention to provide signal artifact reduction, and to provide a single point connector for the set of leads.
Another object of this invention is to provide improved lead materials for improved performance, as well as an improved lead effect modeling (LEM).
It is yet another object of this invention to provide amplifier circuitry that minimizes amplifier saturation and optimizes fast recovery.
The invention provided is an improved method and system for detecting patients' susceptibility to arrhythmia and cardiac tissue abnormality in a noninvasive fashion. In
Single-point connector 17 is configured to electronically mate with electronic interface 18. A top-level block diagram of electronic interface 18 is shown in FIG. 37. In one embodiment, single-point connector 17 advantageously couples 9 electroleads into one plug assembly. As can be seen in
The electronics interface 18, by coupling with computer 27, allows for the injection of low-level electromagnetic energy into patient 35 to alter at least one cardiac signal. The energy is delivered at a subpacing threshold and is typically introduced externally, through patient 35's chest and into cardiac tissue. The subpacing energy is delivered just before a QRS complex event, as determined by the data gathered by the hardware and electronic interface 18, and as analyzed by the software. Electronic interface 18 and attached computer 27 function to process received signals, among other functions. The energy delivery leads are typically leads 7 and 8; however, it is anticipated that circumstances may arise where more or less than two energy delivery leads may be needed. In such cases, greater or fewer leads may be configured to delivery energy. Further, the number of sensing leads may be variable as well, depending on the needs and judgment of the medical professional administering the testing.
The slight transcutaneous biosync or subpacing current is typically introduced by the invention at odd numbers of QRS complex normal sinus beats. Resulting QRS complexes are then compared to the even-numbered unbiased beats. By computer-implemented software, the distinguishable signal differences can then be calculated and displayed. Generally, differences are found between the biased and unbiased QRS complexes in patients with ventricular tachycardia and other indices of arrhythmia or cardiac tissue abnormality. It is anticipated that these input potentials would be extremely small, for example, less than 100 uV, and typically of a duration of less than about 100 mS. Such a current might involve visualization of a possible analog of late potentials throughout the QRS complex. In similar fashion it is within the scope of this invention to apply the biased and unbiased signal analysis to various other types of test methods and signals. The application of external sub-threshold stimulation delivered through the skin surface affects the ECG signals which may be evaluated in a myriad of ways, including Heart Rate Variability (HRV), ST segment elevation, QRST Timing Changes, and T-wave alternans. These methods are currently in use today but have never been used in combination with the novel features of this invention. The combination of external sub-threshold stimulation delivered through the skin surface to change or modulate these measurements is further described herein.
Heart Rate Variability is commonly measured by taking a sampling of R-wave to R-wave intervals from a subject and computing the standard deviation of these intervals. Other methods include the evaluation of modes of distribution of these intervals. For the purposes of this description, HRV shall generally be defined as the evaluation of the intervals between re-occurring activity in the heart. When external sub-threshold stimulation is delivered through the skin surface, these intervals can change. The changes vary from individual to individual. These changes (or lack thereof) can be used to identify an individual's cardiovascular and autonomic condition.
QRST Timing Changes are commonly measured by assessing the variability in spacing between the Q-wave and T-wave of the heart. Other methods include the evaluation of variability between Q-R, Q-S and R-S waves. For the purposes of these claims, QRST Timing Changes may be generally defined as any evaluation of variability in relative timing of any combination of Q-wave, R-wave, S-wave, or T-wave. When external sub-threshold stimulation is delivered through the skin surface, these timings can change. The changes vary from individual to individual. These changes (or lack thereof) can be used to identify an individual's cardiovascular and autonomic condition.
ST Segment Elevation is commonly measured by assessing the amplitude of the heart beat between the S-wave and the T-wave. Other methods include the evaluation of frequency content, amplitude variability and frequency variability. For the purposes of this description, ST Segment Elevation may be generally defined as any evaluation of signals occurring between the S-wave and T-wave. When external sub-threshold stimulation is delivered through the skin surface, these signals can change. The changes vary from individual to individual. These changes (or lack thereof) can be used to identify an individual's cardiovascular and autonomic condition.
T-Wave Changes are currently measured by evaluating sequential T-wave amplitudes for alternans behavior. Other methods include the evaluation of frequency content, and frequency variability. For the purposes of these claims, T-Wave Changes may be generally defined as any variation of signals occurring between the S-wave and the subsequent heart beat. When external sub-threshold stimulation is delivered through the skin surface, these signals can change. The changes vary from individual to individual. These changes (or lack thereof) can be used to identify an individual's cardiovascular and autonomic condition. Use of these techniques include, in one or more combinations:
In summary, it is possible to use any of the above cardiac evaluation techniques with the induced signals of the invention to measure variability of the resulting signals. This variability can be compared to the variability of signals or intervals without stimulation. The relationships and mechanisms for the changes are discernible in these combinations, and provide considerable diagnostic value for the patient and the investigating caregiver.
Computer 27 operates a graphical user interface (GUI) based software, which generally includes a tool bar, a status bar, a display area, and various drop-down menus. The principal GUI is depicted in FIG. 4. The GUI consists of display area 39, status bar 37, tool bar 42, and drop-down menus 46. Tool bar 42 contains button icons that represent shortcuts to many of the functions described below in association with drop-down means 46. Status bar 37 depicts the general status 13 of the software on the left-hand side, technical data 10 regarding the lead sensors and input current in the middle section, and frequency and protocol information 28 generally on the right-hand side.
The lower portion of the GUI depicted in
If "Cancel" 30 is selected on the GUI of
In a particular embodiment of the subject invention, prior to acquiring test data for a particular test, the computer-implemented software will acquire data for a 10-second interval, displaying and indicating detected R-waves or QRS complexes (see FIG. 31). This process allows the operator to confirm the placement of lead system 12, and the sensitivity settings that appear in the GUI of FIG. 7. If the test data is not completely satisfactory to the operator, the steps represented in
Typically, in one preferred embodiment of the invention, an auditory beeping occurs with R-wave acquisition. If no R-wave beeping occurs or if poor signal amplitude is noted, adjustments in the leads may again be required, and sensing verification should be repeated via the GUI of FIG. 12.
In situations where the operator is not performing standard protocols, the system will allow the operator to interactively set the pulse position.
In one preferred embodiment, the final step in the performance of the test sequence function involves performing and recording the test. Prior to performing and recording the test, the software will represent the GUI prompt of FIG. 14. This will allow the operator to control the timing of the test to ensure that both patient 35 and the operator are ready to proceed.
When the "OK" 36 selection is made from the GUI of
This invention anticipates that several other events may occur that would halt acquisition, and similar GUIs to the GUI depicted in
"Signal Averaged ECG" 135 displays signal-averaged ECG information for normal, biased, and difference signals. Typically, in the application of signal-averaged ECG 135, of, primary importance to the medical professional is the flat area immediately following the QRS complex, ST segment 133. ST Segment 133 is targeted because of its lack of signal in normal people (see FIG. 31). This lack of signal allows the recognition of the presence of very small-amplitude signals that can occur in people with conduction problems indicative of a susceptibility to arrhythmia or other cardiac tissue abnormality. Further, abnormal signals may also exist within the QRS and be masked by the higher-amplitude signal present there. Since this invention has the ability to perform comparative analysis between stimulated and non-stimulated beats, a much greater sensitivity may be achieved in areas where a higher natural signal is also present. Additionally, by examining various areas of the QRS complex, information regarding size and position of conduction alteration may also be evident.
If "Options" 128 menu selection is made from View drop-down menu 55, the GUI of
Individual QRS status may be determined from the GUI of FIG. 21. The various options in the QRS Status window 97 are as follows: if the status indicated is "Biased," that means that the QRS complex has a stimulation associated with it. If it is "Normal," the QRS does not have an associated stimulation. The parameter "Valid" in status window 97 means that the QRS has past selection criteria which is included in the averaging. If the LEM stimulation is indicated (not shown), this means that the QRS complex is used for LEM. If "low correlation" is indicated (not shown) in status window 97, the QRS complex was too low and, therefore, was not used in the averaging. If there is a "Bad Interval" indication (not shown), then the preceding or following interval changed by greater than 300 milliseconds. If a "high-rate" status indication is indicated (not shown), the pulse rate exceeded 180 beats per minute and the QRS complex was not used in the averaging. If "manual exclusion" is indicated (not shown), that means that the QRS complex was manually excluded by the operator. If "Bad pulse Positioning" is indicated (not shown), the pulse position exceeded the tolerance set by the medical professional or the default tolerance. Further, it is possible to manually include or exclude a particular QRS from the averaging statistics by using the "Include" 162 and "Exclude" 168 selection buttons on the GUI of
An exemplary result of selecting "View 2 Minute Screen" 123 is depicted in FIG. 22. The 2 Minute Screen mode allows the medical professional to view a selected channel in an overview mode. In this mode, a two-minute portion of the selected channel 138 is displayed on display area 39. R-wave correlation points 124 and stimulation points 127 are indicated on the display area of FIG. 22. R-wave correlation points 124 are longer, white indications (not shown) above the waveform. Stimulation points 127 are red indications (now shown) below the waveform. Note that both Full Resolution 119 and View 2 Minute Screen 123 modes display the current start and end time for the displayed portion of the test on status bar 37 at the bottom of the relevant GUI. Advantageously, as the operator scrolls through the data, these values change to indicate the portion of data currently being displayed.
An exemplary result of selecting "View QRS Change" 125 mode is depicted in FIG. 23. In
When the Signal Averaged ECG menu selection is made from View drop-down menu 55, the GUI of
Another drop-down menu 46 is the Data drop-down menu 58. Data drop-down menu 58 provides access to functions required for loading previously acquired data from storage, such as a hard disk located in computer 27, or from removable storage, such as a Zip™ disk or other removable storage media. Configuration of protocol steps is also supported here, along with typical backup and restore functions.
If "Load Protocol Step" 131 is selected from the drop-down menu, the GUI of
Selection of "Restore" 114 from Data drop-down menu 58 restores data from an external media, such as a Zip™ disk, back to the internal hard drive of computer 27. Further, using the "Export" 195 command, data can be exported to certain spreadsheet software programs.
The "Append To Stats" option 163 can be selected to append the statistics of the current configuration parameters to the file. Advantageously, this option allows all test data sets in the current drive and directory to be processed using the current processing parameters and appended to the selected text, or .TXT, file. This useful option allows for batch processing and results based on altered settings.
Another menu 46 is Help drop-down menu 60. Full index and search capabilities of Help information is available. Further, on-line help, such as information gatherable through the Internet, is also anticipated.
A high-level operator flow chart for the software described above appears in
Another process for arrhythmia detection is that of t-wave alternan analysis. This process involves looking for alternations from beat to beat in the signal produced during the t-wave portion of the heart signal. The t-wave is the portion of the heart signal that follows the QRS "contraction" (see
An overview of the operation of this invention can be seen in FIG. 33. Sensing Leads 202 pass received Signals 248 to the fast-recovery amplifier, at which time the Signals 248 are passed to the Analog to Digital converter 208. Thereafter, Data 250 is used to determine R-wave Detection 237 and for LEM modeling 215. Data 250 is also capable of going to Storage 218, and is further used for Post-Processing 240, where data 250 is eventually displayed to computer monitor 23. During the fast-recovery amplifier stage 254, Blanking Control 212, through Control 253, is used to compensate for blanking. This blanking control is initiated through the Software and Hardware Control Logic 234 via Control 253. Control 259 controls the R-wave detection 235 as it is passed to the Software and Hardware Control Logic 234. Software and Hardware Control Logic 234 further controls a Shunt Control 225 via Control 254; and Control 257 controls Current Controlled Driver 221. Hardware and Software Control Logic 234 passes Data 250 to the Digital to Analog Conversion 228, thereafter passing those Signals 255 to the Current Controlled Driver 221. At the appropriate time, Signal 255 is delivered to Stimulation Leads 206. Post-Processing 240 also performs LEM modeling 215, Digital Filtering 243, and Statistical Calculations 246, described in more detail below.
A significant part of the subject invention is the amplifier and driver circuitry located in electronic interface 18. Electronic interface 18 provides amplification of signals received from lead system 12 and amplifies those signals to a level of impedance readable by the computerized data acquisition/control system, such as computer 27. Electronic interface 18 also takes control signals from the computerized data acquisition/control system, such as computer 27, and provides stimulation into lead system 12, as described above. The amplifier circuitry is designed to record lead signals that occur immediately following the injection of energy into the lead system. The recording typically occurs within only several milliseconds of the injection of energy. Fast recovery is important to the system because of the need to sense electrical information very shortly after a stimulation. In one preferred embodiment shown in
To provide for such fast recovery, several methods are employed. The sensing leads are comprised of fast-recovery material, such as tin, sodium, silver and silver chloride, or other such material know to those skilled in the art, to facilitate rapid dissipation of any energy induced by the system. Further, electronics interface 18 uses a multistage amplification scheme as known to those persons skilled in the implementation of amplifiers, with improvements for fast recovery.
An additional clamping circuit is also employed to aid in the reduced recovery time during stimulation. As can be seen in
Additional techniques and means for improving sensing and analysis of cardiac signals will now be discussed, including both stimulated as well as non-stimulated signals. Such techniques and means include: wavelet decomposition, alternative or passive shunting, detection of ECG alternans, stimulation of alternans behavior, detection of differences between natural and stimulation induced alternans behavior, cardiomyopathy detection techniques, body surface shunting synchronous with the R-Wave on Signal Averaged Electrocardiogram, subthreshold stimulation without capture to reduce the stimulation threshold causing changes to the action potential of a subsequent suprathreshold stimulation with capture, Wedensky transthoracic stimulation, Wedensky phenomenon within the late potential region, wavelet analysis of subthreshold stimulated and control Signal Averaged Electrocardiograms in healthy subjects and ventricular tachycardia patients, QRS complex alternans detected by wavelet decomposition of Signal Averaged Electrocardiograms, and QRS background noise differentiation. Each such means will now be discussed, including reference to
Wavelet Decomposition is a mathematical analysis allowing the study of a particular signal of interest in the presence of other signals. The analysis allows itself to be tuned towards higher sensitivity to one or more particular type(s) of waveforms while reducing sensitivity towards another. This type of analysis is particularly useful when used on ECG data. ECG data can contain specific environmentally present electrical noise, for example 50 Hz or 60 Hz. ECG data may also contain broadband constant or intermittent noise produced by local sources of electromagnetic interference. The dynamics of the ECG waveform itself (as it is produced by the heart) can be defined in both frequency and amplitude. Research has defined such an analyzing waveform for use with Wavelet Decomposition in studying ECG data. This application includes the use of such wavelet decomposition to analyze either the natural ECG or stimulated ECG data produced by an ECG device, including the devices disclosed herein. Also included is the use of wavelet decomposition to analyze combinations of natural ECG or stimulated ECG data produced by an ECG device, including the devices disclosed herein.
This application discloses, inter alia, the methods and apparatus of using the stimulation electrodes (or any large area surface electrodes) in an ECG device, including the devices disclosed herein, as a method of enhancing sensing of cardiac condition. First, these electrodes can act as a shielding mechanism to enhance the sensing of ECG signal. The presence of a large area electrode acts as an electrical shield allowing better sensing of cardiac signal. The use of such an electrode is identified and claimed here.
Embodiments of the present invention also include an optimum electrode configuration to induce non-invasive Wedensky phenomenon in organisms. Wedensky phenomenon is the effect of subthreshold stimulation on the subsequent suprathreshold excitation. Recently, it has been shown that external transthoracic subthreshold stimulation synchronous with the R wave produces Wedensky phenomenon which differs in normal subjects and ventricular tachycardia patients. To produce non-invasive Wedensky phenomenon optimally, sufficient myocardial current density (MCD) has to be combined with minimum MCD variance. A computer model of transthoracic currents was used to study the effects of different electrode systems on mean MCD and its variance. Three 2D horizontal thorax cross-sections were considered with high, middle, and lower sections of ventricular myocardium. Tissue characteristics were taken from an anatomical atlas and represented by conductivities within a rectangular grid of 460�700 nodes. Finite difference model of current flow investigated 30 different frontal electrodes used in 13 different positions against 5 different positions of a dorsal patch (1950 experiments with each cross-section). The current densities within the modeled myocardium of all three cross-sections were considered together (79956 nodes) and for each experiment, the mean MCD and its standard deviation were computed. Independent of the position, there is a positive relationship between the area of the frontal electrode with mean MCD (3.78, 4.29, 4.68, 4.98, 5.18, 5.32, 5.39 (in technical units) for linearly increasing length of the frontal electrode of simulated sizes from 15 to 120 mm) while the coefficient of variance of MCD decreases with the increasing area of the frontal electrode (0.52, 0.49, 0.46, 0.43, 0.41, 0.38, 0.36). The coefficient of variance of MCD was further improved when introducing perforations into the largest size electrodes. However, this improvement was only marginal (lowest coefficient of variance of 0.31 and 0.29 was achieved with un-perforated and perforated electrode, respectively −7% reduction). Embodiments of the present invention provide that non-invasive induction of Wedensky phenomenon involves a large precordial electrode. Furthermore, embodiments of the present invention demonstrate that the variance of myocardial current density is slightly reduced by using perforated electrodes. These embodiments will be further described later in this disclosure.
Shunting is a technique of dissipating unwanted voltage. Use of the devices and methods disclosed herein involve the delivery of energy followed by the shunting of the stimulation leads as a means of reducing the artifact caused by charge remaining on the lead system. This shunting process also has application when no energy is delivered through the leads, and is interchangeably referred to herein as alternative or passive shunting.
By passively changing (shunting) the potential of a large area of the body, an impedance modulation in the body can be realized. The generation of the surface ECG from the heart involves the current flow from cell to cell as depolarization recruitment progresses. This current vector multiplied times the local resistivity gives the local electrical field. The components of that on the skin are what is called the ECG. By pulsing the shunt across the chest it is possible to modulate that resistance (i.e. "impedance modulation"). This is similar to changing the angle of view of the cardiac signal. This altered measurement can also be compared against the non-shifted measurement.
Also disclosed here is the process of shunting these or any larger area surface electrodes together to effectively provide an isopotential at the skin surface. This action can be viewed as "passive stimulation." It can shift the body potentials and possibly alter conduction pathways to allow better sensing of the cardiac condition. This altered measurement can also be compared against the non-shifted measurement. The use of either "impedance modulation" or "passive stimulation" and its effect on the QRS signal is thus disclosed herein.
Alternan behavior consists of the changing of cardiac signal in a modal fashion. That is, one beat will have certain characteristics, the next will have different characteristics, and the following will have characteristics like the first. The process of averaging together alternate beats used in an ECG device, including the devices disclosed herein, allows the measurement of the natural ECG alternan behavior. The extent and change of this measurement can be a measure of cardiac condition. The use of this measurement as an indication of cardiac condition is disclosed and included in this application.
By averaging together alternate beats, the systems and methods disclosed herein allows the measurement of alternan behavior. This method can be useful in the determination of cardiac condition. Thus, this application discloses use of the systems and methods to achieve stimulation-related changes in alternan behavior, or shunting/impedance shifting-related changes (passive stimulation in alternan behavior as a method for detecting cardiac condition). Furthermore, the differences between natural alternan behavior and stimulated alternan behavior can also be useful in determining cardiac condition. This application discloses and includes the use of the differences between these behaviors as an indicator of cardiac condition.
A further use of the devices and methods disclosed herein is to assess conduction pathway changes within the heart by examining the changes in ECG while stimulating and not stimulating the myocardium. Another use disclosed herein is to detect non-conduction related abnormalities of the heart including, but not limited to, cardiomyopathy. The changes invoked by the process of stimulating, shunting, or examining alternate beats could also be used to determine the extent of physical myocardial abnormality. Stimulation related changes, shunting and impedance shifting related changes (passive stimulation), or changes due to average of alternate beats as a method of detecting non-conduction related abnormalities are disclosed and included herein.
Applicants have further discovered improved means for signal analysis by analyzing the effect of body surface shunting synchronous with the R-wave on Signal Averaged Electrocardiograms by comparing the differences between normal subjects and patients with ventricular tachycardia. This study investigated the effects of creating a body surface short circuit synchronous with the R-wave on the spectral profile of signal averaged electrocardiograms.
In 35 patients with EP inducible ventricular tachycardia and in 30 healthy volunteers, 60 to 200 QRS complexes were digitally recorded using orthogonal leads. Synchronous with on-line R-wave detection, two surface patches corresponding to the orthogonal Z lead (a precordial patch and a left dorsal subscapular patch) were electrically connected with negligible impedance for 2 ms. The QRS complexes recorded in this way were averaged and compared with the same number of averaged QRS complexes recorded without surface shunting. Both high-gain signals were decomposed with 53 scales of Morlet wavelets of central frequencies 40 to 250 Hz and vector magnitudes of wavelet decompositions were constructed. The differences between these decompositions were characterized by their surface areas in windows of 0 to 10 ms, 10 to 20 ms, and 20 to 30 ms, etc., after surface shunting.
The area difference was substantially greater in healthy volunteers, as shown by the light bars in
Applicants further compared high-gain electrocardiographic evidence of Wedensky Phenomenon in healthy subjects and ventricular tachycardia patients. Of course it is known that Wedensky Phenomenon is the effect of a subthreshold stimulation without capture that reduces the stimulation threshold and changes the action potential of a subsequent suprathreshold stimulation with capture.
To investigate whether this phenomenon can be documented after transthoracic subthreshold stimulation (2 ms. pulse of 5 to 40 MA between surface precordial and subscapular patches delivered synchronous with R-wave detection), 60 to 200 subthreshold stimulated QRS complexes were signal averaged and compared with the same number of average non-stimulated complexes recorded during the same experimental session. The electrocardiographic recordings were obtained with standard orthogonal leads. In order to detect even minor changes within the QRS complex, each lead of both stimulated and control averaged complexes were wavelet decomposed (53 scales of the Morlet wavelet with central frequencies of 40 to 250 Hz). The wavelet residuum corresponding to the Wedensky Phenomenon was obtained by subtracting the vector magnitude wavelet decomposition of the control QRS from the vector magnitude decomposition of the subthreshold stimulated QRS. The surface of the residuum was investigated in windows of 1 to 25 ms following the stimulation. The test was performed in 35 patients with EP inducible ventricular tachycardia and in 30 healthy controls.
The wavelet residuum showed sharp increase in the spectral power of the stimulated complex that was significantly more marked in healthy volunteers (p<0.01) than in VT patients. This is shown in
In further investigation, patients with electrophysiologic documented ventricular tachycardia (n=35) and healthy controls (n=30) were subjected to a subthreshold external stimulation between precordial and left subscapular patches. Stimuli of 5, 10, 20, and 40 ma were delivered for 2 ms synchronous with R-wave detection. 60 to 200 subthreshold stimulated QRS complexes were averaged and compared with the same number of non-stimulated complexes. Vector magnitude wavelet decompositions (53 scales of central frequencies 40 to 250 Hz) were obtained for both stimulated and non-stimulated complexes and their difference characterized the Wedensky Phenomenon numerically. The surface area of the 3D envelope of the wavelet residuum was measured in a window �5 ms from the R peak (stimulation moment) and in surrounding 10 ms windows.
The wavelet residuum showed a sharp increase of the surface of the 3D spectral envelope at and after the stimulation that was more marked in healthy volunteers than in VT patients, as shown in
Wedensky Phenomenon within the late potential region was analyzed utilizing dose-related separation of patients with ventricular tachycardia from healthy controls. Patients with EP documented ventricular tachycardia (n=35) and healthy controls (n=30) were subjected to a subthreshold external stimulation between precordial and left subscapular patches. Stimuli of 5, 10, 20, and 40 ma were delivered by 2 ms after a 20 ms delay following a real-time R-wave detection. 60 to 200 subthreshold stimulated QRS complexes were averaged and compared with the same number of non-stimulated complexes. Vector magnitude wavelet decompositions (53 scales of central frequencies 40 to 250 Hz were obtained for both stimulated and non-stimulated complexes and their difference characterized the Wedensky Phenomenon numerically. The surface area of the 3D envelope of the wavelet residuum was measured in a window 20�5 ms after the R peak (a window centered around the stimulation moment) and the subsequent 10 ms windows (30�5 ms after the R peak). The areas of the residuum spectral 3D envelope in these windows were statistically compared in the VT patients and healthy controls.
All differences were highly statistically significant, as shown in
In yet another assessment, patients with EP documented ventricular tachycardia (n=35) and healthy controls (n=30) were subjected to a subthreshold external stimulation between precordial and left subscapular patches. Stimuli of 5, 10, 20 and 40 ma were delivered for 2 ms either simultaneously with the R-wave or 20 ms after the R-wave. 60 to 200 subthreshold stimulated QRS complexes were averaged and compared with the same number of non-stimulated complexes (reference). Vector magnitude wavelet decompositions (53 scales of Morlet wavelet with central frequencies 40 to 250 Hz) were obtained for both stimulated and non-stimulated complexes. Local maxima of the 3D spectral envelopes were counted in 50 ms windows following the subthreshold stimulation and compared in VT patients and healthy controls.
In reference recordings,
Although the electrical alternans of the ST segment and T-wave has been extensively researched, the alternans of the QRS complex has generally not been investigated-mainly because of difficulties in detecting it. Applicants' innovations overcome such previous limitations, and allowed further assessment as follows.
In 35 patients with EP inducible ventricular tachycardia and in 30 healthy volunteers, 120 to 400 QRS complexes were digitally recorded using orthogonal leads. From these sequences of beats, the complexes with even and odd order numbers were separately aligned and averaged. The resulting high gain signals were processed with wavelet decomposition (53 scales of Morlet wavelets with central frequencies of 40 to 250 Hz) and the differences between the resulting 3D spectral envelopes were computed. These created alternans-related 3D spectral envelopes and were characterized by surface areas in subsequent 10 ms windows.
The surfaces of the alternans-related 3D spectral envelopes were substantially larger, as shown in
Of the many improvements discussed above, it is worth noting that wavelet analysis is particularly significant. Indeed wavelet analysis is a highly reproducible method for SAECG processing which is as powerful as the time-domain analysis for the identification of ischemic VT patients. As compared to the time-domain analysis, wavelet analysis is not dependent on infarct site, and is able to distinguish post myocardial infarction patients without VT from healthy subjects. As compared to known applications of wavelet representations, Applicants utilized much finer distinctions of scales (7 vs. 54) with a different range of middle frequencies (70-200 Hz vs. 40-250 Hz). Applicants also determined that wavelet analysis of signal-averaged ECGs is superior to the standard time-domain analysis in predicting post myocardial infarction events. In particular, this analysis identifies not only those post MI patients who are at risk of non-fatal sustained ventricular tachycardia, but also those who are at risk of sudden cardiac death. Thus, this is the first discovery of using wavelet analysis for categorical risk analysis with prospectively collected signal-averaged ECG data in an almost consecutive population of MI survivors. As such, a significant advantage of this technology is that compared with standard time-domain analysis, the wavelet decomposition of signal-averaged ECGs provides a more powerful distinction between survivors of an acute MI who are and are not at high risk of further complications.
One additional signal improvement technique involves improved noise management in the QRS realm. When sensing signals from electrodes, a certain amount of environmental background noise is unavoidable. This noise may vary in frequency and direction, causing certain electrode placements to be more sensitive to receiving it than others. The following software-based approach addresses an implementation to reduce sensitivity to this background environmental noise during the processing of data recorded from electrodes.
When sensing signals from electrodes, a certain amount of environmental background noise is unavoidable. This noise can vary in frequency and direction causing certain electrode placements to be more sensitive to receiving it than others. To improve alignment of QRS complexes of multiple channel ECG data (XYZ, multi-lead intercardiac, 2 lead, etc.,) a mechanism which reduces sensitivity to background noise may be applied. The mechanism involves the determination of the signal level of the background noise and the signal level of the desirable signal (in the case of ECG data, the QRS). These parameters are determined for each data channel. The parameters are combined into ratios of Desirable/Background signals (hereby called D/B ratio). Channels with low D/B ratios are excluded from use during QRS alignment. Since it is possible for background noise to vary over time, an alternate implementation of this mechanism could be to assess the signal around each QRS complex for D/B ratio and exclude QRS's based on their individual ratios.
One embodiment of software source code to implement the above wavelet processing for SAECG data may include one or more of the following functionality features:
Although many of the above embodiments have been described in the context of a system and method having non-invasive elements only, it is not necessarily a limitation of this invention. Indeed, in other embodiments it is preferred to combine the above technically advantageous stimulation features and controls with elements of existing ambulatory and/or implantable technology. For example, one embodiment is shown schematically in
Accordingly, it is possible to combine the sensing means of the above described invention as a component and feature of an implantable pacemaker, defibrillator, cardioverter, or similar device. Other elements may also be combined as an implanted component or feature, such as, for example, fast recovery means, timing or synchronization means, processing means, or other features shown in the embodiments of
Thus, it is possible to stimulate externally while sensing and processing the above described signals with permanent or temporary internal system components; or it is possible to stimulate internally and detect and process internally; or in other embodiments it is possible to stimulate internally or externally and detect externally using mobile units such as a mobile pack or the like. In various embodiments of these systems and methods it may be necessary to stimulate so as to capture the ventricle, or be synchronous with the R-wave, in order to avoid patient compromise and to optimize performance. Overall, however, these are techniques that differ in the context of this use form normal threshold testing or mapping techniques.
These embodiments also allow for use of this technology in ways not envisioned or even perceived possible before. For example, in one embodiment, an implanted defibrillator or pacemaker can also periodically establish cardiac baseline analyses using the sub-threshold stimulation and sensing techniques described above but installed in the implanted unit. Moreover, with proper placement, it may be possible to locate the requisite sensing means for this invention at various depths beneath the surface of the patient's external anatomy. Baselines or other analyses may also be performed with the external portable systems described above, or with a partially implanted system component such as a lead configured with stimulation or energy delivery means placed in or near the heart. The further advantage of these new systems is the relatively small amount of energy consumed by such baseline tests and analyses of this invention, a fact of particular relevance to implanted systems. Another advantage of this system is the ability to conduct sub-threshold baseline testing both before and after supra-threshold stimulation, e.g. a defibrillation shock, to consistently and accurately monitor cardiac risk factors, tissue rate of change indicia, heart rate variability, memory effect, or other phenomenon.
Analysis was performed regarding Wavelet decomposition of Wedensky modulated signal averaged electrocardiograms. Investigations were performed utilizing electrocardiographic recordings supplied by Harbinger Medical.
The recordings analyzed originated from Wedensky modulated signal averaged electrocardiograms and were supplied in pairs for each investigated subject. These pairs contained both signal averaged modulated electrocardiograms and control electrocardiograms obtained from unmodulated alternating cardiac cycles. Each recording was given in three orthogonal leads both unfiltered and digitally filtered. The analysis performed utilized the unfiltered recordings.
As with the previous set of electrocardiograms that were processed at the end of 1998, each triplet of orthogonal signal average leads was subjected to the wavelet analysis using 53 scales of Morlet wavelet and from the resulting orthogonal wavelet decompositions, wavelet vector magnitude was calculated. The data of the wavelet vector magnitudes were stored digitally on a dedicated personal workstation and used for a extraction of characteristic parameters. All the data is available and if any further analysis is needed, the computation of the wavelet decomposition does not need to be repeated.
For the purposes of the analysis of this data set, a new version of the wavelet decomposition software package has been programmed. The original implementation which utilized Borland Pascal was transferred into C++ and implemented using a 32 bit compiler by Watcom. A substantial gain in processing time was achieved in this way. With the present version, processing of one set of three orthogonal electrocardiograms including the computation of the wavelet vector magnitude takes approximately four to five minutes on a personal computer equipped with a 450 MHz Pentium II processor. While programming this new implementation of the decomposition system, further experience has been gained and further reprogramming concepts developed that should potentially allow the processing of one recording to be achieved within less than one minute on a suitable fast personal computer.
The parameters extracted from the vector magnitudes of wavelet decompositions were firstly related to the individual decompositions and secondly taken from the differences of the Wedensky modulated and reference recordings that were obtained within the same experiment.
The parameters extracted from the individual recording were related to the localized maxima of the wavelet decomposition envelope. Within each wavelet scale, local maxima were counted in a pre-specified interval relative to the R wave of the analyzed electrocardiogram. These counts, taken within the same time segment, were subsequently summed over the whole spectrum of scales. The numerical parameters obtained in this way represented the general smoothness of the wavelet decomposition and was hence likely to differentiate between subjects with and without disturbed intra-cardiac conduction.
The parameters related to the wavelet decomposition residuum, i.e. to the difference between the vector magnitude of wavelet decomposition of the Wedensky modulated and reference electrocardiograms, were based on calculating the surface area of the residuum. For this purpose the residuum was represented also by a 3-D envelope along individual scales of the original wavelet decompositions and the time synchronized in individual scales. Four different segments relative to the R wave as well as relative to the stimulation moment the surface area of the residuum was calculated. For this purpose, the spatial distance between the individual scales was considered negligible and the surface area of the residuum was represented by the sum of the distances along the 2-D graphs corresponding to individual scales within the specified time segment.
Graphical images of both the original wavelet decompositions of the Wedensky modulated and reference electrocardiograms as well as of the wavelet decomposition residua were produced and visually checked on the computer screen. The images did not substantially differ from the images produced with the previous set of recordings at the end of 1998 and were therefore not printed on paper because of the complexity of the technical work involved. Selected images were converted into transportable bitmaps and used for presentation purposes such as selected slides and poster presentations. Generally, the images suggested that the noise level achieved in the present recordings was slightly lower than compared to that observed previously.
Together with the original electrocardiographic data set, a database of individual subjects was received from Harbinger Medical in which the general clinical distinction between the normal subjects and patients with EP documented ventricular tachycardia was made. From this database, all subjects recorded within the new data set were considered with the exception of 136 recordings that were excluded. As previously observed, the count of wavelet maxima in 50 msec segments distinguishes statistically normal subjects from VT patients.
In the present data set, this distinction was observed in both sub-threshold stimulated and reference recordings. The distinction was namely achieved when analyzing the segments shifted by 20 msec from the R wave as seen in the graphs of
Contrary to the observations made in the analysis made on the previous set of recordings, the distinction based on the maxima count does not differ between the reference and sub-threshold stimulated recordings. This is in line of our present understanding of the differences caused by Wedensky stimulation in the 3-D wavelet decomposition envelopes which seem to produce a rather smooth additional activation pattern.
Despite this present understanding of the pattern produced by Wedensky stimulation in the 3-D wavelet envelopes, a more systematic study investigating the difference in the wavelet maxima was attempted. For this purpose, the whole 3-D wavelet envelope was divided into non-overlapping 10 msec segments. Within mutually corresponding segments, the wavelet envelope maxima were counted and compared in the reference and sub-threshold stimulated recordings. The differences of these maxima count and the bottom being the reciprocal of statistical significance when comparing the data of individual segments of the wavelet envelopes between normal subjects and VT patients. As can be seen in
Similar to the analysis performed with the previous data set, the surfaces of the wavelet residua were calculated in three different modes.
Firstly, the whole envelope of the residuum was divided into non-overlapping segments of 10 msec and comparisons were made between the individual patients and volunteers group (i.e. the groups of subject for whom corresponding experiments were available) for these individual segments. A number of the graphs of the analysis are shown in
Generally, the same observation that was previously made, can be seen in these figures. Healthy volunteers tend to produce higher responses to the sub-threshold stimulations compared to the VT patients. Because of the leakage of the signal in calculating the original wavelet envelopes and their residual difference, the change produced by the sub-threshold stimulation is seen both after and before the sub-threshold stimulus. The separation of the groups, however, tends to be more prominent in segments following the stimulation moment.
The only exception of this general rule is the graph showing the stimulation of 20 mA at the position of 30 msec after the R wave detect. In this situation, the inverse relation between the normal subjects and VT patients was noticed, which is probably due to the small number of individuals involved in this test. All other results are consistent with the previously made observations.
The evaluation of the dose response to the separation of the clinical groups in respect of the stimulation analogy was attempted for the stimulation synchronous with the R wave and for the stimulation delivered 20 msec after the R wave because only in these cases, a sufficient number of individuals were available for a comparative study. The graphs of the dose response evaluation are shown in
Both graphs are highly suggestive of a dose response effect which is different for the stimulation synchronous with the R wave and delayed by 20 msec. However, these observations are to some extent at odds with the observations of the dose response affect made in the analysis of the previous data set. Consequently, the issue of the dose response effect and, likewise, of the optimum stimulation energy should be further investigated.
To guide further investigations in respect of the optimum analytical window positioning and width, a comprehensive analysis was performed comparing the residuum surfaces in windows related to the R wave of different duration. Graphs showing to comparisons in windows symmetric around the R wave are shown in
Generally, it can be concluded that an optimum window should be centered around the sub-threshold stimulation moment and that it should last for at least 10 to 20 msec to achieve a suitable separation of the clinically relevant responders and non-responders to the Wedensky phenomenon.
The observations previously made, especially those that the wavelet residuum surface distinguishes normal subjects from patients with EP documented ventricular tachycardia were not artifactual and seem to be firmly established by these observations. A further study is needed to establish whether these differences are related to the presence of ventricular tachycardia of whether they are merely related to the presence of the underlying cardiac condition such as the ischaemic heart disease. For this purpose, a group of patients with a post-infarction ischaemic heart disease and uncomplicated follow-up after myocardial infarction should be performed. By comparing the Wedensky phenomenon related parameters recorded in such patients to the corresponding parameters recorded in patients with ventricular tachycardia, it will be possible to elucidate whether the observations of the different characteristics of the noninvasively induced Wedensky phenomenon are related to ventricular tachycardia and whether they carry potential prognostic significance.
Because of the small number of subjects involved in the individual studies and because of the difference of the protocol in individual subjects, the data presently available does not allow a firm conclusion on the optimum stimulation moment or on the optimum stimulation energy to be made. Because of the substantial differences in the phenomenon induced synchronously with the R wave and delayed after the R wave, the possibility of stimulating prior to the R wave should be carefully considered. It is also not obvious whether grouping the individual subjects according to the stimulating energy in milliamperes is the optimum procedure. It might be more appropriate to consider the true energy delivered during the stimulation since the same current might have different effects in different individuals with different trans-thoracic impedance.
If the appropriateness of the present setting of computing the wavelet residuum surface is confirmed in the study of uncomplicated ischaemic heart disease patients, search for additional data analytical procedures will probably not be necessary. Once such a confirmation is available, the development of a standard version of the data analytical procedures should be organized so that an analytical system can be distributed to different centers which will allow to compare results obtained in a truly multi-site manner.
Embodiments of the present invention also included analysis of computer simulations of optimum electrode configuration for the induction of noninvasive Wedensky Phenomenon in man. A technical study was conducted that used a 2-D computer model of trans-thoracic cross-sections to simulate current density within ventricular myocardium with a special aim of investigating the optimum properties of an electrode system that might be used for the noninvasive induction of Wedensky phenomenon in man.
An anatomical atlas has been used to select three representative cross-sections of the human thorax within the lower mediastinum that corresponded approximately to the upper (FIG. 64A), middle (
The cross sections were scanned digitally and converted into color bit map images that were manually edited in order to achieve suitable distinction of different morphologies. Color images of the bit maps that were obtained in this way are shown in
The images of the cross sections shown in
The individual tissue types were assigned electrical resistances that are listed in the table in FIG. 65. The table contains values in technical units and their absolute numbers are meaningless. Nevertheless, the relationship between these individual resistance characteristics corresponds to the relationship between electrical resistance of true tissue types. Individual tissue structures were considered homogenous. In particular, no difference between the electrical resistance of the myocardium in respect of fiber orientation was introduced.
The model was implemented on an advanced model of a personal work-station that was equipped with a 450 MHz Pentium II processor. The resolution of the bit map images shown in
The model was implemented as a grid of electrically conductive rectangular mesh with individual resistance values assigned to individual nodes rather than connectors. These corresponded to the resistance constants as introduced for each tissue type considered.
When introducing simulated electrodes on the frontal and dorsal part of the model, electrical current passing through the structures of individual sheets was computed according to the Kirkhoff laws by the standard finite difference method. In more detail, the Kirkhoff laws were used to describe each of the 2-D models by a set of linear equations with as many variables as non-empty nodes in each sheet. The set of such equations was solved by Gauss-Jordan elimination method and the distribution of potential was obtained for each computational experiment.
In each experiment, the potential of the front electrode introduced into the computational experiment was considered to equal to zero while the potential of the electrode simulating the dorsal part was considered to equal to one on a hypothetical voltage distribution scale. From these two potentials, the voltage distribution across each whole sheet of the model was computed and the voltage differences between neighboring nodes were, together with their resistance constants, used to calculate the current density for each node of the model.
The values of the current densities obtained for the ventricular myocardium were considered and statistically evaluated for each electrode combination.
Compared to the defibrillation models which aim at achieving a minimum current density in a pre-specified percentage of myocardial tissue, the concepts involved in simulating the optimum electrode positioning for the induction of Wedensky phenomenon is different. The phenomenon relies of sub-threshold stimulation and should therefore be ideally introduced with the same level of sub-threshold current density in the whole myocardium. Since the level of the current density can be made variable by introducing different voltage gradient between the frontal and dorsal electrodes, the optimum position of the electrodes will be such that the variance of the myocardial current density is the lowest. In practice, this means trying to identify such a combination of frontal and dorsal electrodes which will lead to the lowest coefficient of a variance (i.e. the standard deviation divided the mean) of myocardial current densities. This approach was used in this modeling study.
Since the dorsal patch is unlikely to have a very significant effect of the efficacy of the system, a simple 15 cm continuous patch was considered in five different positions starting at the very right edge of the dorsal electrode area. (Note that the area for electrode placement of the three sheets of the model correspond fairly each to the other.) This position at the very right edge was termed "Position 0" and was further shifted in steps of simulated 2 cm. Positions 1 to 4 (shifted by 2 to 8 simulated centimeters) were obtained in this way.
In a similar manner, the positioning of the frontal electrode was introduced. Thirteen different positions of an electrode were considered. Position 0 again corresponded to the very right edge of the frontal electrode areas and further 12 positions were introduced by shifting the original position by simulated 7� mm. The frontal positions of the electrode were combined with 30 different shapes of the electrodes. Shapes of electrodes similar to the ones utilized herein are depicted in
As it can be seen in
All the different possibilities of the dorsal patch in positions 0 to 4 were combined with all different electrode shapes 1 to 30 in frontal electrode positions 0 to 12 and were considered for each sheet of the model. That is, for each sheet of the model, 1,950 individual computational experiments were performed and for each of these experiments, the mean and standard deviation of the myocardial current density was obtained both for the individual sheets as well as for the composition of the myocardial tissue combining all the three sheets together.
Graphical summaries of the individual results obtained in the whole set of 1,950 experiments are shown in
It can be clearly seen that the larger the area occupied by the electrode, the better its performance. The best results were obtained with the shapes of the electrode 19 and 24, followed by the shape 28 and finally followed by the shape 7. The differences are not very large but it should also be noted that the stability of the electrodes modeling a very large patch with perforations (e.g. shapes 19 and 24) are more stable in terms of achieving very low coefficient of variance of the myocardial current density for different frontal positionings. Electrode 7 which models the large single patch is without any perforation is less efficient in this respect.
It should be also noted that the coefficient of variance of the myocardial current decreases from electrode shape 1 to electrode shape 7 dramatically which suggests that for achieving a low coefficient of variance of the myocardial current density, one should use a rather large precordial patch.
It should also be noted that the variability in both mean and standard deviation of the myocardial current density introduced by varying either the frontal electrode position or the frontal electrode shape and different dorsal position is considerable.
The model is of course very restricted since it is based only on the three individual sheets and does not include the true 3-D structure of the heart and thorax which would be needed for a more accurate prediction of the effects of different electrode positionings. Nevertheless, even from this restricted set of experiments, significant conclusions may be drawn.
For the optimum induction of Wedensky phenomenon in man, a rather large frontal electrode should be used. The electrodes presently available of the experiments performed by Harbinger Medical seem to be appropriate for this purpose.
Since the differences between the solid patch front electrodes and perforated path front electrodes seen in the model were rather negligible, current experimenting performed by Harbinger Medical should be continued with the presently available electrode design. The observation of the model should be tested that a more pronounced induction of the Wedensky phenomenon will be achieved when placing the frontal electrode more medially than laterally.
Additional embodiments of the invention also consider perforated frontal electrodes. The model suggests that a large electrode composed of two segments with a larger center opening was the optimum in this two 2-D study. Probably, electrodes composed of several large squares with openings of about 2 cm in-between would correspond most to the model prediction.
As previously discussed, various means of optimizing the noninvasive detection and localization of potential or actual sites of arrhythmias are possible and hereby enabled. In addition to the embodiments disclosed previously, it is possible to enhance this invention by careful electrode design, location, configuration, size, and current delivery means. For example as depicted in
In yet another embodiment, a plurality of small electrodes may be substituted instead of a singular large electrode in order to properly and more accurately deliver energy. Such small electrodes may deliver energy simultaneously or separately under hardware and/or software control.
These embodiments of the invention, utilizing portions of nonconducting material within the normal periphery of stimulation leads or electrodes, may actually result in substantial increases in energy performance of these materials. This optimizes field shaping and current delivery to the subject. This technique may also facilitate the staging of current among leads in sequential, seriatim or another pattern of energy delivery not normally used or associated with this diagnostic procedure. In one example, this staging of current may facilitate optimization in some form of synchronization with the cardiac sinus rhythm or other bodily rhythm.
While the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications, and variations will be apparent to those skilled in the art in light of the foregoing description. Accordingly, it is intended to embrace all such alternatives, modifications, and variations which fall within the spirit and broad scope of the invention.
|Cited Patent
|Filing date
|Publication date
|Aug 6, 1990
|Jun 2, 1992
|Kroll Mark W
|Method and apparatus for non-invasively determing a patients susceptibility to ventricular arrhythmias
|Feb 27, 1995
|Sep 17, 1996
|Brewer; James E.
|Method for automatic, adaptive, active facilitation to access myocardial electrical instability
|Nov 14, 1995
|Jan 6, 1998
|Cambridge Heart, Inc.
|Using related signals to reduce ECG noise
|Title not available
|Jul 29, 1998
|Feb 11, 1999
|Harbinger Medical Inc
|System and method of noninvasevely determining a patient's susceptibility to arrhythmia
|Citing Patent
|Filing date
|Publication date
|Sep 18, 2007
|Oct 18, 2011
|Harbinger Medical, Inc.
|Method and apparatus for determining susceptibility for arrhythmias using wedensky modulated electrocardiography and alternans analysis
|Apr 24, 2006
|Oct 25, 2011
|Medtronic, Inc.
|Method of delivering PESP/ICC as well as adjusting the refractory period of the heart
|May 31, 2007
|Jan 15, 2013
|Nervomatrix Ltd
|Transcutaneous electrical therapeutic device
|Oct 4, 2011
|Aug 25, 2015
|Nervomatrix Ltd.
|Electrode for finding points of low impedance and applying electrical stimulation thereto
|Dec 18, 2003
|Aug 26, 2004
|Luana Pillon
|RXc graph and RXc Z-score graph methods
|U.S. Classification
|600/516, 600/515
|International Classification
|Cooperative Classification
|European Classification
|Oct 16, 2007
|Reissue application filed
Effective date: 20070201
|Jul 22, 2008
|Fee payment
Year of fee payment: 4
|Sep 25, 2009
Owner name: HARBINGER MEDICAL, INC., MINNESOTA
Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER PREVIOUSLY RECORDED ON REEL 023085 FRAME 0304;ASSIGNORS:HOIUM, HAROLD H;RYAN, STEPHEN J;MALIK, MAREK;REEL/FRAME:023282/0159;SIGNING DATES FROM 20000628 TO 20001026
|Nov 4, 2011
Free format text: LIEN;ASSIGNOR:HARBINGER MEDICAL, INC.;REEL/FRAME:027174/0205
Effective date: 20111103
Owner name: PATTERSON THUENTE CHRISTENSEN PEDERSEN, P.A., MINN
|Jun 12, 2012
|Reissue application filed
Effective date: 20120424
|Sep 17, 2012
|Maintenance fee reminder mailed
|Feb 1, 2013
|Lapse for failure to pay maintenance fees
|Mar 26, 2013
|Expired due to failure to pay maintenance fee
Effective date: 20130201


text:
Inflammation and swelling of the sinuses can cause blockage of air and
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amount of pressure delivered through a nasal mask worn during sleep.
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Nasal deformity may be either functional or cosmetic. Functional
describes nasal breathing blockages, snoring, decreased smell or taste,
nose bleeds or chronic inflammation. A crooked septum (the middle
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collapse or weakening of structures in the nose. Cleft lip, cleft
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symmetry, length and width or tip of the nose and may be changed through
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text:
- 59Promote
Framed Art Print
Abstract Thinking Remixby DesignLawrence
Choose from a variety of frame styles, colors and sizes to compliment your favorite Society6 gallery, or fine art print - made ready to hang. Fine-crafted from solid woods, premium shatterproof acrylic protects the face of the art print, while an acid free dust cover on the back provides a custom finish. All framed art prints include wall hanging hardware.
great work
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Thanks Texnotropio and Nicklas, appreciate the support.
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You know, there's a new comic out, The Origin of Skeletor on DC. The script is kind of meh, but the art is so friggin' good. It got me thinking of Skeletor again, hence the reference. It was drawn by Frazer Irving.
Thanks for the info John I might check out the local comic store in the area. I always get a lot of inspiration and ideas from comic books creating my digital art piece...
Yeah, there's excellent work out there. Frazer Irving, Guy Davis, Mike Mignola... Tons of amazing stuff.
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cool one..well done!
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