text:
Page 1
Insights from Natural Infection-Derived Immunity to Cholera Instruct
Vaccine Efforts
Marcela F. Pasetti and Myron M. Levine
Center for Vaccine Development, Department of Pediatrics and Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA
remains a notable disease burden in much of the developing
world, affecting several million individuals and leaving an esti-
mated toll of ?100,000 deaths annually (52). Outbreaks with un-
acceptably high case fatality rates continue to occur in areas of
rest (11, 15, 17, 52).
It is known from epidemiological studies and experimental
challenges in healthy adult volunteers that a prior episode of clin-
ical cholera induces serogroup-specific protection against clinical
fully understood. Vibriocidal antibodies (mainly, but not entirely
directed against lipopolysaccharide [LPS] antigen) are a measure
to infection (13, 29, 31). Studies performed in the 1960s with
household contacts of cholera cases showed that vibriocidal titers
of ?160 were associated with an ?86% lower risk of developing
of ?160, only 1 (1.7%) developed cholera diarrhea and only 1
(1.7%) other developed inapparent infection, compared with 28
(14.7%) of 190 nonimmune individuals (titer, ?20) who devel-
oped cholera and another 24 (12.6%) who developed inapparent
infection (29). Among these household contacts of cholera pa-
tients, every 2-fold rise in vibriocidal titer was associated with a
50% decrease in risk of cholera infection. These data mimic what
Mosley et al. also found in large population-based surveillance
studies accompanied by serosurveys in which every 2-fold rise in
the annual incidence of clinical cholera cases (30).
Two types of oral cholera vaccines consisting of whole killed
organisms are commercially available: Dukoral (Crucell, Swe-
den), which contains V. cholerae O1 serotype Inaba and Ogawa
strains of both El Tor and classical biotypes admixed with recom-
binant cholera toxin B subunit (CTB), and Shanchol (Shantha
Biotechnics-Sanofi Pasteur, India) or mORCVAX (VaBiotech;
Vietnam), which contain a mix of several V. cholerae O1 strains
trolled field trials, these vaccines (or their prototypes) were found
preventing cholera in adults and older children (9, 47). The effi-
children. The protection afforded is also short-lived (?2 to 3
generally leads to a more robust and durable protection upon
reexposure, which is evident in both young and old individuals
and lasts up to a decade (2, 10, 25).
A thorough understanding of the bacterium-host interactions
that lead to disease, the immune responses induced, and the
mechanisms that mediate protection against subsequent V. chol-
erae illness can help guide efforts to develop even more effective
vaccines (e.g., requiring only a single dose and more protective in
to infected patients and individuals exposed to V. cholerae. Our
current understanding of cholera pathogenicity and immunity
comes from studies conducted in areas where the disease is prev-
alent or through experimental infection of healthy adult volun-
teers (human challenge models). When human challenge studies
were performed in the 1970s, 1980s, and 1990s, some of the most
critical techniques to assess immune responses of modern immu-
nology were not available and therefore many relevant questions
could not be answered. Although instructive, it could be argued
that some results from challenge studies in subjects in industrial-
ized countries may not be generalizable to endemic cholera, since
volunteers that used the same virulent cholera strain given to
North American volunteers achieved 90% attack rate with a dose
that was only 1 log higher (46). Investigation of disease in its nat-
ural context is ideal but very difficult. Assembling cohorts, pro-
curing clinical specimens, and performing sophisticated immu-
nological assays during field studies in resource-poor areas where
cholera is endemic can be logistically complicated, requiring in-
frastructure, equipment and expertise, and substantial financial
resources. Cultural differences and social and political conflicts
can complicate the work further.
Undeterred by these difficulties, a group of very talented and
committed scientists from the International Centre for Diarrheal
Disease Research in Bangladesh (ICDDR,B), and the Massachu-
setts General Hospital and Harvard Medical School joined efforts
to establish a highly successful and productive collaborative re-
search program focused on dissecting host-pathogen interactions
and human immune responses to V. cholerae. This work has gen-
erated a wealth of new knowledge that has informed the cholera
of enteric diseases in general. In a series of papers published re-
cently in Clinical and Vaccine Immunology (4, 22, 33, 48), includ-
ing the accompanying article by Johnson et al. (19), as well as in
Published ahead of print 19 September 2012
Address correspondence to Marcela F. Pasetti,
Copyright © 2012, American Society for Microbiology. All Rights Reserved.
November 2012 Volume 19 Number 11Clinical and Vaccine Immunologyp. 1707–1711 cvi.asm.org
Page 2
other relevant publications (1, 14, 16–18, 20, 21, 23, 41, 49), this
collaborative research group has extensively described the im-
and urban Bangladesh, comparing clinical infection versus vacci-
nation. They meticulously investigated systemic and mucosal im-
munity by measuring serum and mucosal antibodies, antibody-
secreting cells (ASCs), antibodies in lymphocyte supernatants
(including some that are difficult to obtain, such as mucosal bi-
opsy specimens and intestinal fluids) using state-of-the-art tech-
nology. Several aspects make this work novel. Not only did these
and vaccination, but they also examined how these markers were
associated with (and possibly contribute to) protection in a pop-
ulation in an area of endemicity. They also studied younger and
older children, which is particularly relevant considering the dif-
pared to adults.
In analyzing serum antibodies, these investigators found that
both clinically infected and vaccinated individuals had compara-
ble levels of antibodies to LPS and CTB. However, infected indi-
viduals developed stronger vibriocidal responses than those who
had been vaccinated. While these antibodies have been tradition-
found that serum IgA against CTB and LPS could also predict
subsequent study failed to confirm this association. Nevertheless,
the authors point out that infected patients who became ill had
lower IgA LPS baseline titers than the household contacts, sug-
disease (33). Interestingly, serum antibodies against cholera anti-
gens typically return to baseline levels within a year, while protec-
tion lasts much longer (14, 16). Mucosal secretory IgA (sIgA) an-
tibodies were detected in duodenal fluids, but these also returned
to baseline within 6 months (49). No correlations were found
between IgG antibodies and protection.
The ICDDR,B-Massachusetts General-Harvard research con-
sortium also found that individuals from areas of endemicity in-
fected with V. cholerae developed IgA ASCs specific for LPS and
CTB, which peaked 7 days after the onset of disease (36, 37) and
expressed the gut-homing receptors ?4?7 (35). Circulating IgA
ASCs are typical markers of mucosal priming after enteric infec-
tion or oral vaccination, and they can be detected transiently in
circulation while migrating back to mucosal effector sites. Muco-
sal LPS-specific IgA ASCs were demonstrated in duodenal biopsy
specimens from cholera-infected patients; the cells remained de-
tectable for at least 6 months, even in the absence of detectable
anti-LPS IgA in secretions. These cells may resume antibody pro-
duction when appropriately stimulated (49).
Mucosally primed antigen-specific B cells may also become
antigen reexposure. IgG and IgA BMcells specific for LPS, CTB,
following disease (14, 18). In contrast, individuals given Dukoral
oral cholera vaccine failed to develop LPS BMresponses; IgA and
(1). The ICDDR,B-Massachusetts General-Harvard group was
the first to report the presence of BMcells against V. cholerae an-
tigens. In fact, they were the first to report BMresponses against a
servation of IgA and IgG BMcells specific for LPS was surprising
based on the traditional notion that T-independent antigens lack
BMcell production. Subsequently, investigators studying other
enteric pathogens (e.g., Shigella and Salmonella) showed induc-
tion of LPS-specific BMcells, some of them with gut-homing ca-
pacity (?4?7?), in healthy adults orally immunized with live at-
tenuated organisms (43, 44, 50, 51). It has been shown recently
that T-cell-independent class-switched BMcells (CD27?IgA?)
can be generated locally in the human gastrointestinal tissue, in-
dependent of germinal center reaction (5). A high point of the
Ryan, Qadri, and Calderwood's work has been the association
tion against infection in household contacts of cholera patients.
These findings were published in Clinical and Vaccine Immunol-
ogy in June 2012 (33). The authors did not find associations be-
cells specific for LPS, but they cautioned that due to the high
heterogeneity of the individual responses (33), the number of
samples might not have been sufficiently numerous to provide
statistical power to detect such associations.
An article published in Clinical and Vaccine Immunology in
March 2012 focused on immune responses in younger (2 to 5
years of age) and older (6 to 17 years of age) children after either
vaccination or infection (22). Although the responses to the oral
killed-cholera vaccine Dukoral were comparable between the two
groups, they were much lower than those detected in infected
children. Infected children had higher vibriocidal antibodies, sys-
temic IgA and IgG anti-LPS, and IgG and IgA LPS and CTB-
was made that the lack of responses against LPS may explain, in
part, the shorter duration and lower level of protection in vacci-
nated younger children compared to the responses in older indi-
sent a "surrogate" (i.e., nonmechanistic correlate) rather than a
"true correlate" of protection (i.e., a mechanistic correlate), since
serum antibody titers drop quickly, while protection persists for
(34). Likewise, mucosal antibodies decline even faster. The inves-
tigators propose instead that a mucosal anamnestic response me-
diated by BMcells (directed primarily to the LPS) appears to be
necessary for long-term protection against cholera (7). It would
make sense for the host to mount a quick, refined, and local re-
sponse when reexposed to the pathogen instead of producing an-
tibodies continuously. This hypothesis is in agreement with
results obtained in North American volunteers who were rechal-
lenged 3 years after experimental infection with V. cholerae O1.
dicative of immune memory) and remained protected in the ab-
sence of the repetitive exposure to the organism and immune
where cholera is endemic, moderate baseline responses can con-
trol low-level repeated exposure, but a strong anamnestic re-
dose. The idea of BMcells being key contributors to protection is
very plausible and probably true for other enteric bacteria as well.
BMcells (with mucosal-homing capacity) are being increasingly
cvi.asm.orgClinical and Vaccine Immunology
Page 3
To facilitate the study of BMresponses in vaccine studies, the
ICDDR,B-Massachusetts General-Harvard group offers a techni-
cal improvement. Based on the strong correlation observed be-
tween the frequency of IgG BMcells measured by enzyme-linked
produced by these cells, they propose the analysis of antibodies in
a culture supernatant of expanded BMcells as a proxy for BM
responses (18). Measurement of antibodies is easier, multiple an-
a later time point (18). This method has been successfully applied
in the evaluation of other vaccine candidates (38, 50, 51).
The Ryan, Calderwood, and Qadri group also performed a
thorough analysis of T-cell responses in cholera-infected or vac-
cinated individuals, including children (4). They showed that
cholera induces an early proinflammatory response (clinically si-
lent) and priming of antigen-specific CD4?Th1- and Th17-type
cells that were not observed in Dukoral recipients. The failure of
this oral vaccine to activate adequate CD4?T-cell responses may
account for the limited efficacy of this vaccine (20). In an article
published in Clinical and Vaccine Immunology in August 2012,
they showed for the first time that natural infection resulted in
follicular helper (CXCR5) and gut-homing (?7) receptors along
with production of Th1 (gamma interferon [IFN-?]), Th17, and
Th2 (IL-13) cytokines (4). Vaccination, on the other hand, in-
duced modest TEMresponses (without IL-13), but only in older
children (6 to 14 years old). Younger children (2 to ?6 years old)
did not develop TEMbut did apparently develop regulatory T
(Treg) cells that produced interleukin-10 (IL-10). T-cell help is
sponses in older vaccine recipients correlated with their IgG BM
responses in vaccinated younger children with the lower efficacy
and shorter duration of the protection afforded by the vaccine in
responses, was associated with protection. The article does not
address, nor do the authors discuss, a possible (CTB-mediated)
Since CTB is immunologically cross-reactive with the Escherichia
coli heat-labile toxin (LT), it is difficult to ascertain the origin of
these responses and their role in protection is also unclear (27).
The two other oral cholera vaccines on the market (Shanchol and
protection. Live vaccines also lack CTB and were found to be
protective, although they contain other immunogenic proteins.
possibly modulate responses to other antigens. An early study in
Bangladesh showed that an initial episode of cholera caused by El
Tor resulted in relatively poor and short-lived protection against
subsequent El Tor exposure and virtually no protection against
the classical biotype vibrios. In contrast, an initial episode of clas-
sical biotype cholera conferred strong and enduring protection
against exposure to either biotype (10). One possible explanation
is that CT expressed by the classical biotype modulates the re-
sponses to critical protective antigens differently than CT ex-
pressed by El Tor. Currently circulating hybrid strains of El Tor
that express a toxin similar to that produced by classical biotype
may help explain why recent episodes of El Tor (due to hybrids
expressing classical CT) may be better immunizing events than
also contribute to host defenses against cholera and account for
some of the differences between naturally acquired and vaccine-
induced protection.
evidence underscoring the relevance of LPS-specific responses in
protection against cholera. In fact, LPS and antigenic derivatives
are being studied as potential vaccine candidates. In the article
published in this issue of Clinical and Vaccine Immunology, John-
son and colleagues investigated potential immunogenic targets of
the V. cholerae LPS focusing on the O-polysaccharide antigen
(OPS) (19). The OPS of V. cholerae defines serogroup specificity,
and as mentioned above, protection derived from natural disease
is serogroup specific. The authors examined circulating levels of
patients and found them to be similar and strongly correlated.
vibriocidal responses. They concluded that the O-antigen region
seems to capture most of the humoral response to whole LPS and
contributes substantially to the observed vibriocidal responses.
approach that is being pursued to prevent disease caused by Sal-
monella, Shigella, and other enteric pathogens (32, 45).
Overall, the reduced and short-lived efficacy of the oral killed-
cholera vaccine appears to result from its reduced immunogenic
anisms needed to engender a robust and long-lived protection.
Conceivably, live vaccines that can mimic cholera infection could
ural infection, ideally after a single immunization. Among the
most promising live attenuated cholera vaccines are CVD 103-
Institute, China), both genetically engineered toxin-deficient
North American volunteers (26). This vaccine strain was also
tested in a randomized large-scale controlled field trial in an area
of high endemicity in north Jakarta (39). Following administra-
tion of vaccine or placebo in this densely crowded urban slum,
incidence of cholera fell by ?80% compared with pre-field-trial
rates. However, evaluating the cases that did occur, the calculated
vaccine efficacy was low (39). It is now widely believed that in-
direct protection provides an explanation for the Jakarta re-
sults. In an innovative reanalysis of data from the mid-1980s
(precursor of Dukoral), Ali et al. showed that when approxi-
mately one-half of subjects in the community receive cholera
and in the controls, through indirect protection (3). Indeed, as
the incidence drops drastically, the levels of vaccine efficacy
become insignificant as the disease largely disappears. CVD
vaccine by a new manufacturer (PaxVax) is under way, with the in-
tention to make it available once again as a single-dose cholera vac-
Peru 15 was safe and immunogenic in adults and children in
Bangladesh but has not yet been tested in phase 3 studies. Other
live oral vaccine strains that have been found to be well tolerated
and immunogenic in humans are V. cholerae 638 (12), and CTB-
expressing strain VA1.3 (28). Both are attenuated EL Tor deriva-
November 2012 Volume 19 Number 11 cvi.asm.org 1709
Page 4
tives; strain 638 protected adult volunteers in a challenge study
(12). Other vaccine candidates, including protein subunits and
lipopolysaccharide conjugates, are under development (8, 42).
An interesting new approach pursued by the ICDDR,B-Mas-
sachusetts General-Harvard investigators and published in Clini-
cal and Vaccine Immunology in February 2012 is the use of a
neoglycoconjugate vaccine made from a synthetic terminal hexa-
saccharide of the Ogawa O-antigen conjugated to BSA (48). Oral
priming with a live attenuated V. cholerae, followed by a transcu-
taneous boost with the neoglycoconjugate cholera vaccine and
as serum IgG and IgA anti-LPS and vibriocidal antibodies. Im-
vaccine was not immunogenic when used alone (40), but only
when it was preceded by oral priming; higher responses were in-
duced by transcutaneous as opposed to subcutaneous boosting.
The authors suggest that a boosting vaccine may prolong natural
and vaccine-induced protection (48). It remains to be seen
whether this approach elicits gut-homing ASC and BMcells.
More effective and affordable vaccines that confer greater and
longer-term protection following administration of just a single
dose, along with strategies to improve sanitation and access to
clean water, could reduce the risk of cholera in a cost-effective
manner. International health organizations have recommended
large-scale vaccination to reduce disease and improve public
derived from natural infection can instruct vaccine development
efforts and advance the goal of disease control. The ICDDR,B-
Massachusetts General-Harvard team has unraveled many of the
intricacies of the host immune responses against V. cholerae and
identified key effector responses that should be required of any
high-risk groups.
We thank Rezwan Wahid and Raphael Simon (CVD) for critical reading
of this commentary.
We dedicate this article to the memory of Ana Fraccarolli de Pasetti
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November 2012 Volume 19 Number 11 cvi.asm.org 1711


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Hustle and Grow
The Valleys hip-hop landscape has always had its fair share of hustlers and dreamers, and the pimps and players behind newly launched TrilLife Entertainment are no exception. Their goal? Simple. They wanna put Arizonas club and hip-hop scenes on the map.
There [are] a lot of great hip-hop artists in Arizona, but they dont have a lot of backing, says Jessica Anderson, Vice President of Entertainment. We want our events to start changing that.
TrilLifes drive for hip-hop dominance begins on Tuesday, March 22, with the AZ Movement Hip-Hop Event at Exit 7 Bar & Grill. Local artists Cactus Jack (a.k.a. The King of AZ), T Rex, and 360 (featuring Da Beat Junkie and Prophet) will perform. Food and drink specials will be offered and DJs spinning the hottest hip-hop will be on hand. 21-and-over only.
Tue., March 22, 9:30 p.m., 2011
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Park City, UT (PRWEB) November 30, 2013
Today, Zane Benefits, the number one online small business health benefits solution, published new information on missing open enrollment.
According to Zane Benefits' website, one big change brought on by the Affordable Care Act is that individual health insurance plans will have open enrollment periods -- set times when people can buy a qualified health plan through the Health Insurance Marketplace, or outside the Marketplace from an insurer or agent.
The first open enrollment period to buy a qualified health plan is happening now, running October 1, 2013 through March 31, 2014.
Missing open enrollment and not enrolling in a health plan by March 31, 2014 means that the opportunity to buy coverage for the year is likely over - unless there is a significant change in circumstance.
Missing the deadline means a penalty for not having insurance will likely go into effect. In 2014, the penalty is $95 per person up to a maximum of three times that amount for a family ($285), or 1% of household income if greater. The penalties increase in 2015 and 2016.
What are the 'Significant Changes'?
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Zach Heckendorf "What's the Scenario?"
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Town Square
'Random' knife attack in Old Palo Alto injures one
Original post made on Oct 3, 2013
Read the full story here Web Link posted Thursday, October 3, 2013, 8:54 AM
Comments (10)
a resident of Professorville
on Oct 3, 2013 at 10:41 am
FYI, 100 Block of Melville is not in Professorville. It's on the other (south) side of Embarcadero. That's OLD PALO ALTO.
a resident of Another Palo Alto neighborhood
on Oct 3, 2013 at 10:47 am
[Post removed.]
a resident of Another Palo Alto neighborhood
on Oct 3, 2013 at 12:39 pm
Old Palo Alto ain't what it used to be. In the old days, the most you had to fear was being egged by the Paly students.
digital editor of Palo Alto Online
on Oct 3, 2013 at 1:16 pm
Eric Van Susteren is a registered user.
You're absolutely right. We've changed the headline to reflect your astute correction. Thanks for your help!
a resident of Old Palo Alto
on Oct 3, 2013 at 1:17 pm
I agree that this story does not make sense. Was his car searched?
a resident of Old Palo Alto
on Oct 3, 2013 at 1:33 pm
To Anonymous, in another neighborhood...
You're right. Old Palo Alto isn't what it used to be. Now the cheapest house in Old PA, a two bedroom teardown, just a few houses in from Alma, costs $2M. And that's only if you have all cash.
a resident of Southgate
on Oct 3, 2013 at 2:36 pm
1 bedroom apartment on lytton apartments ..$325.00 month. little dining area and bathroom. 1973.
a resident of Old Palo Alto
on Oct 3, 2013 at 8:02 pm
Two condos near us, a few yards from Alma, sold for 2.2 mil each.....no yard, no garage. Go figure,
a resident of Palo Verde
on Oct 3, 2013 at 9:00 pm
"He attacked the man with a 3-inch pocket knife."
Isn't it time to register pocket knives?
a resident of Leland Manor/Garland Drive
on Oct 5, 2013 at 6:29 am
Just think if he was able to get his hands on a gun.
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Southern California chain snags La Boulange space in Palo Alto
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text: My family and I came for a simple getaway. For my wife to shop and my daughter and I to play in the pool. Expectations were met. Price was right. Location was on the plaza. Restaurants were good, not great. Our largest issue was that roosters woke us up. Needless to say, an issue outside the control of the hotel.


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Is The Nike Mag Coming? All The Questions That Still Need Answers by Zack Schlemmer
adidas Crazyquick – Upcoming Colorways
April 4, 2013 BY Brendan Dunne / 0 / 5
Adding just a bit more color to the upcoming adidas Crazyquick line is this latest preview. Included are the black/lead and the electricity colorways that our readers have already had ...Read More
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April 2, 2013 BY Brendan Dunne / 0 / 5
You had to anticipate that the adidas Crazyquick would suit up in the burning bright "Electricity" look from adidas sooner or later. Sure enough this brand new basketball d...Read More
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The special colorways have started to roll in the for the adidas Crazyquick, the latest of which is this McDonald's flavor. More specifically the sneaker was created for wear at ...Read More
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March 27, 2013 BY Brendan Dunne / 1.5 / 5
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March 15, 2013 BY John Kim / 0 / 5
One of the best visuals of the 2012 March Madness Tournament was seeing the entire Baylor squad wearing those incredible jerseys and the insane "Electricity" colorway of th...Read More
adidas CrazyQuick – A Detailed Look
March 9, 2013 BY Brendan Dunne / 0 / 5
The adidas CrazyQuick is here to change the world of basketball footwear. The adidas team whipped up the sneaker to minimize the amount of time the athlete's foot spends on the f...Read More
adidas Crazyquick "Notre Dame"
March 8, 2013 BY Brendan Dunne / 0 / 5
After we broke the word on the adidas CrazyQuick, Sneaker News it ready to show you some more upcoming colorways branching out from that John Wall Wizards look. Shown here is a pair dr...Read More
Sneaker News Talks adidas CrazyQuick with the Adidas Innovation Team
March 8, 2013 BY Brendan Dunne / 0 / 5
Not long after the introduction of adidas BOOST, the adi team is already prepared to unveil a second wave of innovation in 2013. This time around the goal is making athletes quicker, a...Read More
adidas CrazyQuick – Official Images
March 7, 2013 BY Brendan Dunne / 0 / 5
After the most extensive testing and research process they've ever put into a basketball sneaker, adidas is finally ready to unleash the adidas CrazyQuick to the world. The new t...Read More
adidas CrazyQuick Basketball
March 7, 2013 BY John Kim / 0 / 5
Today, adidas Basketball held a media event to unveil the all-new adidas CrazyQuick Basketball – an innovative approach to boosting speed and quickness on the hardwood floor. The...Read More


text: More from SI Report: Dodgers release pitcher Freddy Garcia Report: Dodgers release pitcher Freddy Garcia Marshawn Lynch sports gold cleats for Super Bowl Marshawn Lynch sports gold cleats for Super Bowl Louisville vs. FIU: Game time, live stream, TV coverage Louisville vs. FIU: Game time, live stream, TV coverage Pittsburgh-area high school football player dies after... Pittsburgh-area high school football player dies after... Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire NBA agents: Players won't go to Clippers this summer if Donald Sterling still owns team by Marc Weinreich Email Posted: Mon May. 12, 2014 Updated: Thu Jun. 12, 2014 Three-fourths of the NBA owners need to vote in favor of Donald Sterling being forced to sell the team in order for it to happen, which could take months. ( Jonathan Alcorn/Getty Images)Multiple agents for NBA players said their clients won't go to the Clippers this summer if embattled team owner Donald Sterling still has a stake in the team.In a report Monday from Sean Deveney from The Sporting News, one agent said he knows his players won't go to play for Sterling because they don't want to help "that guy make even one dime.""...I know I have players who just won't go there now, not until Sterling is gone completely. If there is even a chance that you're going to help that guy make even one dime, a lot of guys are not going to go play there. It is going to be something they will have to deal with when July comes around."Free agency begins July 1, when teams can officially begin negotiating and recruiting other players. Whether that happens with the Clippers remains to be seen, as the agent said "the damage has been done" and that the team will be crossed off as an option by many players in the league when they look toward the free agency market."I can tell you that there are players who will cross them off the list before free agency even starts. This was really personal for some guys, and I mean guys who are not Clippers or never been Clippers. It's just hard and not everyone is going to want to walk into that situation. The damage has been done."LeBron James said this past weekend that it's the players' position that no-one from the Sterling family should own the team. His comments come as Sterling's wife, Shelly, works toward divorcing her billionaire husband and will look to transfer ownership to herself if three-fourths of the NBA team owners force him to sell.NBA spokesman Mike Bass said that "all other team owners' interests are automatically terminated as well" if Sterling is force to sell, including anyone related to him, as per the NBA contract Sterling signed when he purchased the team for $12.5 million in 1981. Forbes estimates the Clippers franchise to be worth approximately $575 million this year. Shelly's attorney fired back at the NBA on Sunday night, claiming that U.S. and California laws trump any contracts set forth by the league. SI WIRE: Charles Barkley responds to criticism over fat jokes Promoted Stories Comments


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Figure comes with snap-on blaster and two projectile accessories.


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THE WOLVERINE - Reviews and Discussion Thread
View Single Post
July 25 2013, 05:18 PM
Dick Whitman
Location: Behind the mask of Donald Draper
Re: THE WOLVERINE - Reviews and Discussion Thread
It proves Days of Future Past is a direct sequel to the Last Stand. They are not pretending it did not happen. Its possible history will be forever changed at the end though. But it would have been foolish to completely ignore it. Most in the audience who saw it would be baffled
Dick Whitman
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text:
Hi Tonya, I have been on your program for about two years now. I do a lot of reading. I find your articles, books and products...
Love the New Cream
Hello Tonya, I just wanted to say I love the new face cream; I also loved the old one which seemed a bit lighter. I like the new one better and like the fact it has more sea buckthorn oil in it. Maybe offer both formulas, one day and one night cream. They both smell wonderful. I have really oily skin and both work well for me. I am also 50 years old and the new formula seems to be doing the trick for around the eyes. I am also about 80% raw food.
Submitted By:
11/28/2011 - 23:45


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Separate names with a comma.
Discussion in 'The Welcome Section' started by Ballcrusher, Jul 10, 2006.
met a few guys at pod on sunday 9"th and recamend this site here i am
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Briefs Encountered (Hardback)Julian Clary
Hardback Published: 29/03/2012
- Not in our warehouse
Whoever said the afterlife would be easy...Noel Coward is the toast of twenties society...a brilliant playwright, composer and entertainer whose witty songs and pithy lines don't quite tell the full story. Goldenhurst, his house in Kent, provides a place where he can be himself. And more importantly where he can be with his lover, Jack, without fear of arrest or judgement...But their romantic idyll is ruined, first by the arrival of Noel's demanding relatives and then by a mysterious death...Many years later, film star and Coward fan Richard Stent buys the house from its current owner. But Richard has problems of his own. Goldenhurst is supposed to be a respite from all his worries but this is a house with a very rich and not always pleasant history. And more than one thing is about to go bump in the night...This is a haunting tale of love, obsession and a house full of spirits, not all of them blithe...
Publisher: Ebury Publishing


text:
Happy 33rd Birthday, Adam Lambert!
One of the most successful American Idol contestants of all-time celebrates a birthday today.
Adam Lambert is 33 years old!
One of the most successful American Idol contestants of all-time celebrates a birthday today.
Adam Lambert is 33 years old!
Arguably the most beloved celebrity in Hollywood celebrates a birthday today.
Twins Jana Duggar and John David Duggar, the second and third oldest among TLC's 19 Kids and Counting, passed the quarter century mark on January 12.
Happy 25th birthday to Jana and John David!
He's been known as the boyfriend of Miley Cyrus. And as the brother of the Sexiest Man Alive. And, of course, as Gale Hawthorne.
Today, however, Liam Hemsworth only goes by one title: BIRTHDAY BOY!
One of the most attractive human beings on the planet celebrates a birthday today.
Zayn Malik is now 22 years old!
Perhaps the most beloved person on Earth - and definitely the most beloved British woman among American women - celebrates her birthday today.
Yes, the Duchess of Cambridge herself, Kate Middleton, is now 33 years old!
Nina Dobrev is taking a bite out of another year of life today.
The actress, in the midst of filming The Vampire Diaries Season 6, is now 26 years old!
Gia Giudice turns 14 years old today, but she almost certainly won't be enjoying a very happy birthday.
Teresa Giudice reported to prison on Monday after a premature celebration with her oldest daughter. She has had reportedly had minimal contact with her family in the days since.


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Hawks Peak
From $115 / night
Description from the manager
Description from the manager
Bedrooms: 2/
Bathrooms: 2/
Sleeps: 5/
Type: House
This is a very comfortable 2 Bedroom Condo in Seven Devils, just minutes from Hawksnest Tubing and Zip Line! It is very comfortably decorated with a nice King bed in the master bedroom, two twins in bedroom 2, and a large comfortable couch that is wonderful during the day, but also very comfortable to accommodate one additional guest at night. There is plenty of room on the floor, if additional guests would like to bring an inflatable mattress or sleeping bags. We can accept up to 8 guests in this property in a family scenario where the additional guests are children.
Seven Devils is located centrally between Boone, Banner Elk and Grandfather ...Read more
About the manager
About the manager
Carolina Cabin Rentals, Inc.
Carolina Cabin Rentals, Inc.
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We currently have two catalogues available to view. Our Irish Art Auction is on Tuesday 29th September and viewing commences on Friday 25th September.
Our Design Auction catalogue is also available to view and vieiwing commences ion Friday 1st October.
Please visit the catalogues section to view either, or both, catalogues.
The Design Catalogue is now available to view onlineposted on Sep 11, 2015
The catalogue for our forthcoming Irish Art auction is now available to view online
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Growing up, Richard Foos dreamed of becoming a social worker, a reflection of his bedrock belief in the Jewish concept of tikkun olam, or healing the world. As a college student at USC in the early '70s, he helped establish an organization called The Free Store, which gave residents...
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December 1, 2005 | 7:00 pm


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Here's something to cover your ears with – the fluffy and pleasantly warm hats of the new BUFF winter collection! Be quick – winter is approaching!
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News & Events
Press releases are written and distributed by Denison's Office of University Communications.Subscribe to Denison Press Releases
Kristina Keidel '17, from Cincinnati (45249), the president of the college's Active Minds chapter, a national mental health advocacy organization, was recently selected as a member of the National Active Minds Student Advisory Committee (SAC) for 2015-2016.
Tawnee GreenRiver '16 is studying human development as it relates to interactions across cultures in Italy at the Umbra Institute, a study abroad program in Perugia, Italy.
Richard T. Berman has accepted the position of Director of Career Exploration and Development. Berman currently serves as director of the Career Center at Oberlin College and will transition into his new role over the course of the spring semester.
After setting a number of significant high-water marks over the last several years, Denison University's Admissions Office has seen even more remarkable gains in 2015.
The Center for Learning and Teaching will provide a variety of seminars, teaching tables, mentorship and other support to help faculty explore and strengthen pedagogy.
Denison University is pleased to announce that Davis Projects for Peace will fund two initiatives proposed by Denison students. Denison is one of only 16 schools in the nation with two proposals funded in 2015.
Dr. Grant Jones, a member of the Denison class of 1988, has been honored with a place in the prestigious Academic All-America Hall of Fame. Jones is a successful orthopaedic surgeon and volunteers for the Special Olympics and Pelotonia Bike Race among other philanthropic ventures.
Denison Venture Philanthropy (DVP), a unique Denison University student program organized around philanthropy, will present $10,000 and 200 volunteer hours to the Look Up Center in Newark.
Denison University has announced that Deirdre N. McCloskey, well-known economist, historian and rhetorician, will serve as the keynote speaker at the college's 174th Commencement ceremony on Saturday, May 16, 2015.
The National Academy of Television Arts and Sciences (NATAS) has announced that George Bodenheimer, former ESPN President, CEO and Executive Chairman, member of the Denison University class of 1980 and Denison Trustee, will be honored with the Lifetime Achievement Award for Sports.
Denison University student Sophie Lovett '18, from Charlotte, N.C., has been accepted to the Marine Resource Population Dynamics Workshop at the Keys Marine Lab in Layton, Fla.
NASPA, the national association for student affairs administrators in higher education, has recognized a Denison University student leadership initiative, D. U. Lead, as the Gold Award Winner for Student Union, Student Activities, Greek Life, Leadership, and related Excellence. D.U. Lead is an intensive weekend institute for first year students in the Denison community.
The Ohio Foundation of Independent Colleges (OFIC) has announced that Denison student Rachel Auerbach, a junior from Mt. Horeb, Wisc., has been selected to receive the OFIC 2015 Service-Learning Leadership Award.
Sarah Kosling '14 and will depart for Nepal to begin training as an agriculture extension volunteer, under the auspices of the Peace Corp program. Kosling will live and work at the community level working to improve food security for rural families.
Denison University announces that the Granville Golf Club has been renamed as the Denison Golf Club at Granville, and that the Donald Ross-designed public golf course will reopen in March.
Megan Ansbro '09, who graduated summa cum laude with a bachelor of science degree in biology, is the recipient of a 2015 Gates Cambridge Scholarship, which awards her a full scholarship for full-time postgraduate degree in any academic area offered at the University of Cambridge in England.
Denison University is notable as a top college, and especially for students seeking great academics, outstanding career preparation and generous financial aid, according to The Princeton Review. Denison is one of the top schools profiled in "Colleges That Pay You Back: The Best Value Colleges and What It Takes to Get In - 2015 Edition."
Denison issues a call for candidates from the Class of 2015 to serve as the Recent Student Member of the Denison Board of Trustees. The candidate will serve from October 2015 through April 2017.
The Association of Physical Plant Administrators has announced that Arthur Chonko, director of facilities services at Denison University, has received the Certified Educational Facilities Professional credential.
Denison University's Office of the Provost has announced that Dena Speranza will be the college's Chief Information Officer. Speranza will transition from her current position as Denison's interim CIO to her new role on Monday, Jan. 12.
Denison was one of five colleges who will participate in a $2 million grant from Mellon, which is a response to the rising interest by undergraduate students in an increasing number of world languages such as Mandarin and Arabic, as well as Hebrew, African and Latin American indigenous languages.
The Ohio Development Services Agency has awarded Denison University a $1.4 million tax credit under the Ohio Historic Preservation Tax Credit Program. When combined with federal tax credits between $2.6 and $2.9 million could be offset toward the cost of renovating the Inn.
The Central Ohio Planned Giving Council honored Peter and Janet Halliday '59 with the "Leave a Legacy Award" at a program which recognizes outstanding achievement by individual, foundation and corporate philanthropists, fundraising volunteers and professional fundraisers.
Serving as treasurer, president and board chair in Columbus BalletMet's early years, Nancy Strause '59, worked with community leaders to develop a strong Board and viable financial base. She was honored for her work on Tuesday, Nov. 25, by the Association of Fundraising Professionals of Central Ohio.
Fadhel Kaboub, associate professor of economics at Denison, is the president of the newly launched Binzagr Institute for Sustainable Prosperity, an independent public policy think-tank dedicated to the promotion of interdisciplinary research in the service of an improved quality of life for all members of society. The institute will disseminate alternative public policy solutions that address a wide range of socio-economic problems faced by the global community.


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Scattante Scala MTB HelmetBuilt with aggressive lines and all-mountain features, the Scala MTB helmet delivers solid performance when you're cruisin' fast on the trail or gearin' up for some big tricks. Aluminum-reinforced, In-Mold construction provides unparalleled protection while remaining lightweight. 26 vents cool your head, visor protects your vision and ExoLoc retention system gives you a strong, stable fit over rough terrain.
- In-Mold construction with aluminum reinforcement enhances durability without compromising lightweight performance
- 26 sweeping vents provide superior airflow and ventilation
- Visor protects your eyes from sun, rain and debris
- Adjustable ExoLoc retention system for a secure, comfortable fit
- Soft straps with buckles make adjustments quick and easy
Scattante Scala MTB Helmet
- colors:
- Black (Black), Bronze (Bronze), White (White)
- retention system:
- Exo Loc
- sizing:
- vents:
- 26
- weight:
- 298g
- rating:
- 4.5


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A trip to the paintball field is the only way to treat an itchy trigger finger, outside of expensive rash creams or petting a shark backwards. Scratch the itch with this Groupon.
Choose from Three Options
$20 for an upgraded rental package for one (a $40 value)
$39 for an upgraded rental package for two (an $80 value)
$75 for an upgraded rental package for four (a $160 value)
Each player receives:
- An upgraded paintball gun rental with feeder
- Nitro bottle
- 100 rounds of paintballs
- Empire E-Vent goggles

Four-hour open-play sessions take place Saturdays and Sundays from 9 a.m. to 1 p.m. and 2 p.m. to 6 p.m.

Futureball Paintball Inc.
One empty school bus, 27 abandoned cars, and a desolate two-story house are the only refuges for combatants roving an expansive urban field. Fourteen additional playfields set the stage for games, surrounding players in open fields and dense forests. It's at Futureball Paintball's 115-acre facility that friendly paintball and Airsoft battles unfold each day and have unfolded for more than 20 years. While vehicle carcasses characterize the urban landscapes, two airfields exhibit red inflatables that mimic the ruins of ancient bounce castles. Between games, a 5-acre picnic area serves as neutral ground to strategize and nibble snacks.
To ensure fair play, Futureball Paintball's staff leads brief orientations and monitors all action. They can also repair and upgrade guns.
95% of 93 customers recommend
"Listen to the refs, they do know best and they are awesome!"
"Go when the weather is colder, you'll appreciate the layers more! Very fun. :)"
"Very friendly staff and great fields to play on. Safety was a priority and rules were explained well. Great service and we had a blast playing. Would highly recommend!"
9269 E Mi State Road 36
Whitmore Lake, MI 48189
+12484460772Get Directions


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"Comedy Draft" at Tempe Improv
By Jonathan McNamara
Halfway through "Comedy Draft" on Sunday, MC Bryan Ricci got up on the small stage in the cabaret lounge at Tempe Improv and said something I wasn't expecting.
The audience had already been assaulted by a few local comics including Steve "The Short Bus" Krause, who made light of his disability by pointing out that he risked his life getting his wheelchair onstage.
"If there's a fire, I'm fucked," he said. "You people aren't going to save me."
There was also Stevie Ray Fromstein, who ended his set with this zinger:
"Have you ever started dating someone, you think they're normal, and then they freak out on you?"
A murmur of agreement floated up from the audience.
"Next thing you know, they're all, 'Untie me! Untie me!'"
It was at that moment, as Fromstein left the stage, that Ricci made his announcement: Norm McDonald was headed for the stage.
That's right. The very same Norm McDonald from Dirty Work, "Weekend Update" on SNL, and his own short-lived sitcom walked on stage holding a massive Coke.
The comic veteran riffed about how he asked for a Coke and got a gigantic bottle of it before demonstrating his ventriloquism prowess. He didn't have a dummy (he hasn't bought it yet, 'cause he doesn't know how this is going to work out), so he asked the audience to pretend a dummy named Walter was sitting in a bag on stage. McDonald got Walter "out" and started a conversation with the dummy that no one could see and said both his and the dummy's lines in his trademark monotone voice.
It was unexpected, but then that's how the Comedy Draft goes. Ten or 12 comics get onstage throughout the night. Some are veterans. Some are rookies. Most tried out new material.
For example, James Henry Heard had never used his bit on the difference between dating cougars and 20-year-olds before. A 20-year-old won't tell you when you're doing something wrong, he said. She'll just say, "Harder." A cougar, on the other hand, will tell you, "Harder . . . to the left . . . no, MY left . . . right there! Don't move! Don't move!"
As for McDonald, he received the most laughter of the night when he ended his set by saying he had a really great joke he wanted to tell us before he got offstage. One very awkward moment later, he said, "Nah. I can't remember it," and started to climb offstage. Then he stopped and looked back at the crowd. "It was really good though."
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HN-CLC003 Catskill
Matson Country Kitchen IslandItem # HN-CLC003
- Oil-finished yellow birch hardwood with 2-inch thick top
- Includes slatted shelves, drawer, and towel rack
- Adjustable leveler feet compensate for uneven floors
- 48W x 24D x 36H inches
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- Adequate Storage
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Just assembled two days ago but is nice addition to kitchen. looks and works great.
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Q: "What are the dimensions between the shelves?"A: From the middle shelf to the bottom of the drawers is 10.25 inches high. From the middle shelf to the bottom shelf measures 14 inches. The middle shelf can be adjusted up or down by 3 inches.
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Matson Country Kitchen Island
The Matson Country Kitchen Island offers authentic provincial French style, with a warm and inviting finish and sleek chrome towel bar. A pair of slatted shelves provide ample storage for your kitchen, and it also includes an extra-large-capacity drawer. This island features adjustable leveler feet to compensate for uneven floors. The Matson is made from oil-finished natural yellow birch hardwood, which is indigenous to the Northeastern U.S. and ranges in color from blond to a darker walnut shad


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You want to be in the know . Guys are on the ground at chambers as we speak , spud news immenent . This is not a rumor but a fact according to Altima . House 19 selling now is weird without a doubt , and if my account manager sold prior to news of any caliber never mind the potential of Altimas news . Wow is all I can say and very poor investment on house 19 . Take advantage of the weak hands and accumulate on lows , great things are in the works as we speak and the best is yet to come way to much upside and calibrating my eyes on four pooled sections and whistler, as well as 100% Altima wells , we got lots of cash now to get things going on our own an wouldn't surprise me if Altima made financing stall for this reason .
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He is my Master - Complete Collection (DVD)
Title: He is my Master - Complete Collection
Volume: DVD
Running time: 300
Distributor: ADV Films
Release date: 2009-10-06
Pre date: 2009-08-09
Suggested retail price: $39.98
Age rating: 14+
Teenage millionaire Yoshikata lives on his own in a magnificent mansion, and, having fired the original maids, needs help keeping up the place. Enter Izumi and Mitsuki, two girls of Yoshikata's age, who accept his offer of to fill in as live-in maids. Along with Anna, another maid, the three girls live with the eccentric Yoshitaka in a goofball comedy that brings laughs with every episode.
Japanese 2.0 with English Subtitles
2 Discs
(added on 2009-07-28, modified on 2009-07-28)
- Reviewed in Shelf Life (October 5, 2009)
- Reviewed by Theron Martin (October 4, 2009)
- Encyclopedia information about He Is My Master (TV)


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Edmonton, ABCanada
August 21, 2013
I am an investor focusing on multi-family purchases (12+ units in AB, BC, Sask and ON). In the middle of a land development deal in Saskatoon. Looking to meet some go getters here in Edmonton to bounce ideas off of. Cheers, Mara
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Such a dynamic seminar! I enjoyed your presentation but I also learned a lot from it. I am motivated to go back to my office and try some of the methods today!
We, at National Provider Compliance Corporation, believe that when healthcare providers are compensated fairly and on time for their services, our Nation's healthcare climate will improve greatly.
We are proud to offer a wide variety of courses and educational tools to help providers gain control over their national and local required changes and updates. We offer specific courses for healthcare and dental providers to meet these challenging needs.
Our "ICD-10 Preparation and 2016 Local Medicare Changes" course is designed for all healthcare providers that deal with Medicare and private insurance companies. The course focuses on what your practice needs to do in order to successfully transition to ICD-10 on the October 1st implementation date. We also address your current, local Medicare changes, compliance with new policies, and how to effectively deal with insurance companies to ensure maximum payment. You will learn how to save time and money and to STOP losing money that is rightfully owed to you. This course is recommended for all healthcare providers and organizations that are billing medical claims. For a detailed list of topics covered, click on the course description link below.
Our "Local Dental Insurance Coverage, Changes and Updates" course is designed to help dental offices understand changes and updates to their insurance billing along with steps and procedures to collect the maximum lawful reimbursement due to the provider. Dental providers need to know how to get dental claims paid fast under prompt payment laws, how to implement local and national changes and how dental plans limit your revenue. The course also covers how and why you should be billing medical insurance for your dental patients and the impact of ICD-10 on dental providers. This course is recommended for all dental providers and staff. For a detailed list of topics covered, click on the course description link below.
Such a dynamic seminar! I enjoyed your presentation but I also learned a lot from it. I am motivated to go back to my office and try some of the methods today!
Attended the seminar in FL. The seminar was very informative, eye opening, covred a lot of information that seemed "grey" before and the speaker was wonderfull!


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Maricopa County Mugshots of the Week: In Rare Form
At the end of the week, we bring you a roundup of visitors to the desert's own Fourth Avenue Jail. To be considered for our Maricopa County mugshots of the week, get arrested, strike a pose, and we'll take care of the rest.
This week, we find some inmates in rare form. Enjoy.
Charges: Resisting arrest, criminal damage The Thinker, Maricopa County Sheriff's Office, 2014 10.)
Charges: More like hairhead, right, little Hitler?
Charges: Burglary, shoplifting Woo-hoo, Avondale.
Charges: Failure to appear Is this an advertisement for Skittles?
Charges: Marijuana transportation I'm sorry, I thought this was America.
Charges: Resisting arrest, threatening Tough year to be a D-backs fan.
Charges: Probation violation I'd like to think Crazy's tan-line came from wearing a jester's hat.
Charges: Probation violation, failure to pay a fine, criminal trespassing Whatever that means, it sounds disgusting.
Charges: Dangerous-drug possession, possession of drug paraphernalia Probably sounds like Pavarotti.
Charges: Knowingly displaying a fictitious license plate, shoplifting, failure to appear, driving on a suspended license The 1986 Motor Trend Car of the Year.
Charges: Possession of a weapon in a drug offense, marijuana possession If you're a bad parent, tell your kids this is the Little Mermaid's dad.
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Three sexual abuse lawsuits against former Elmo puppeteer Kevin Clash will not proceed after the U.S. Court of Appeals upheld a district judge's July 2013 ruling that the cases fell outside the statute of limitations for civil action, according to BuzzFeed.
In 2012, Kevin Clash was accused of abusing multiple men when they were minors; Clash resigned from Sesame Street that November, after working on the show for nearly 30 years.
"Personal matters have diverted attention away from the important work Sesame Street is doing and I cannot allow it to go on any longer," Clash said at the time. "I am deeply sorry to be leaving and am looking forward to resolving these personal matters privately."
See this story on www.buzzfeed.com


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Select Local Merchants
Sharron's School of DanceRead MoreLook like a pro when you hit the floor at Sharron's School of Dance in Twinsburg. Parking is plentiful, so visitors can feel free to bring their vehicles.9840 Ravenna RdTwinsburg, OH US
Lisa's School of DanceRead MoreIf dancing is on the agenda, be sure to swing by Lisa's School of Dance in Streetsboro for an exciting (and exhausting) experience. Parking is plentiful, so guests can feel free to bring their vehicles.9307 Route 43Streetsboro, OH US
Dance ConnectionRead MoreHuron locals love Dance Connection for its down-home groove and hip-shaking moves. Forget the hassle of street parking and head to Dance Connection for easy access to parking lots.615 Main StreetHuron, OH US
The Donna Colman School of DanceRead MoreYou'll be soaking up new moves left and right when you stop by Hudson's The Donna Colman School of Dance. Parking is plentiful, so guests can feel free to bring their vehicles.5107 Darrow RdHudson, OH US
Fred Astaire Dance Studio Chagrin FallsRead MoreThe consortium of professional instructors at Fred Astaire Dance Studios, which was cofounded by the legendary toe tapper himself, shepherds students of all ages and skill levels through lessons that span the style spectrum. Low-pressure private sessions allow enthusiastic teachers to fine-tune individual students' techniques and form, using their expert eyes and mechanical dancing shoes preprogrammed to do the Charleston. Patrons can learn how to cavort through classic waltz and fox-trot romps or swivel through the modern steps of salsa, swing, or samba. For dancers hoping to hoof it up in a social setting, the group practice parties provide a one-night extravaganza of instruction, demonstrations, and amateur firewalking.8225 E Washington St.Chagrin Falls, OH US
Bobbie Barna's Dance StudioRead MoreWhether you're an experienced dancer or just an amateur twinkle toes, check out Bobbie Barna's Dance Studio in Solon. For the best workout in the city, just try one of the personal trainers here. When you try the cross fit challenge, you'll gain new capability by performing high intensity, varied workouts. Parking is plentiful, so visitors can feel free to bring their vehicles.32901 Station StSolon, OH US


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In Pictures: Seven best practices for Cloud security
Learn how to protect yourself in the Cloud from the next vulnerability and/or wide scale attack.
27 May | View galleries
Learn how to protect yourself in the Cloud from the next vulnerability and/or wide scale attack.
27 May | View galleries
While having instant access to your information via the Cloud is a major bonus to productivity and convenience, there's a risk that the security trade-off will be too high.
08 Apr | View galleries
Enterprises are now clamoring for the corporate security gateway to give way to the new Cloud application security gateway.
03 Oct | View galleries
Here are 10 companies and why they have a shot at challenging Amazon.
27 Aug | View galleries
Two-factor authentication is often held up as a best practice for security in the online world, but Dropbox on Wednesday announced a new feature that's designed to make it even tougher.
Katherine Noyes | 13 Aug | Read more
Security has been an increasingly dominant theme in the enterprise software chorus in recent months, and on Tuesday Salesforce added a new voice to the mix with Shield, a set of platform services designed to help companies build secure apps.
Katherine Noyes | 15 Jul | Read more
It's no secret that security has been a tripping point for enterprises considering cloud storage, but OwnCloud on Tuesday took a fresh step toward alleviating such concerns with the addition of a new encryption framework.
Katherine Noyes | 08 Jul | Read more
VMware is hoping to convince CIOs to centralize single sign-on access to all kinds of apps with Identity Manager, which can run in the cloud or on-site and also offers application provisioning and a self-service catalog.
Mikael Ricknäs | 17 Jun | Read more
For many small and midsize companies, having someone else remotely monitor and manage their computer network is a no-brainer. The managed service provider can improve efficiency, reliability, security, and maintenance -- all while lowering costs and freeing up IT staff to work on more strategic projects.
Maria Korolov | 12 Jun | Read more
The number of personal cloud users increases every year and is not about to slow down. Back in 2012 Gartner predicted the complete shift from offline PC work to mostly on-cloud by 2014. And it's happening.
Victoria Ivey | 16 Dec | Read more
It's so far been another sorry, sorry year in the technology industry, with big name companies, hot startups and individuals making public mea culpas for their assorted dumb, embarrassing and other regrettable actions.
The amount of electronic information (e.g., documents, images, emails, videos) organizations produce is staggering. Storing all your digital data in your data center can be expensive. That's why cloud storage -- which often comes at a fraction of the cost of storing the information on-premises -- has become increasingly popular.
Jennifer Lonoff Schiff | 17 Apr | Read more
Almost nine tenths of ICT decision-makers are changing their cloud buying behaviour as a direct result of Edward Snowden's allegations of large scale clandestine cyber-surveillance, a study published today by NTT Communications claims.
, the open source software management company, picks the top 10 open source projects launched in the past year, based on stats collected from the
Black Duck | 28 Jan | Read more
The leaking of classified documents detailing the data collection activities of the U.S. National Security Agency earlier this year reignited some long-standing concerns about the vulnerability of enterprise data stored in the cloud.
Jaikumar Vijayan | 01 Jan | Read more
Research shows that 94% of CIOs believe that enterprise mobility has become an important part of their enterprise IT strategy. While there are many benefits for business, there are still risks when it comes to security. This whitepaper looks at the steps all organisations to take when it comes to supporting a mobile workforce.
CSO interviews CSO moderators on key takeaways from the CSO CXO Series event sponsored by Trend Micro in Melbourne 31st July 2015. Interview conducted by David Braue, CSO Moderator.
Safeguarding the crown Jewels
Effective collaboration and mobility to help employees tap into entirely new ways of working.
Computerworld Exchange talks to David Siroky, Director Dell Enterprise Solution & Alliances Team about the next generation Data Centre
CSO interviews CSO moderators on key takeaways from the CSO CXO Series event sponsored by Trend Micro in Melbourne 31st July 2015. Interview conducted by David Braue, CSO Moderator


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On Tap: Being successful at a beer festival
One Claw
Westbrook Brewing Co., Mt. Pleasant
6 percent ABV
Style: Rye Pale Ale
Profile: Hoppy, earthy, balanced
Pairing: Barbecue ribs, grilled salmon
Price range: $9 per six pack
Availability: Mellow Mushroom-Anderson and specialty beer stores
Appearance: A quick pour from can to pint glass yielded a rich golden brown beer with a slight haziness after settling. The white foam was lush for a moment and turned into a light topping that lasted most of the beer.
Smell: Rich with floral and earthy hops and a lighter malt backbone. The rye is slightly hidden while the hops shine.
Taste: Bold and rich from the first sip, it mellows a bit later into a well-balanced beer that could be enjoyed once, twice and three times in a setting.
Mouth feel: A light- to medium-bodied beer with more coating on the tongue than anticipated.
Overall: Like most of Westbrook's beers, this one is deceivingly good. It seems fairly normal at first, but the more you drink it the more it stands out from the rye-pale pack.
I have been thinking about beer festivals a lot lately. It could be because October is coming and this is the time that Oktoberfest celebrations start up. It also could be because there are a few big festivals scheduled in Asheville and Charlottle this September. But the more likely reason is because I have been helping out with the first beer festival in Anderson coming up on Sept. 7.
It's called the Carolina BrewHaHa, and it's going to be a one-day event featuring unlimited samples of beer from about two dozen breweries for four or five hours, depending on the level of ticket you purchase.
All this thought about beer festivals also got me thinking about what you should know before going to them and how you can keep your wits about you while enjoying all the beer they have to offer. There are plenty of ideas that folks have but only a few are based in reality and sound science. I thought I would give you the benefit of my knowledge before these beer festivals hit and hopefully save you some time and energy before you head out to the BrewHaHa, Brewgrass or Charlotte Oktoberfest this year.
Get your water in early and often: Water is your friend at a beer festival. It won't just help to keep you hydrated. It also will be something to break up the sheer number of beer flavors you are bringing in throughout the day and will allow you to enjoy the beers more because you are tasting them without all the interference from your previous beer. Either remember a water bottle or, if you would rather, make sure you buy water every time you think about it so you will be a happier beer festival attendee. It might mean you have to hit the port-a-potty a few more times during the day, but your body will thank you.
Make a food walk-by while enjoying the first couple of samples: It can be tempting just to hit the next beer tent after you get your first sample of beer, but this is the best time to browse the food tents and see what they have. It's when the lines will be the smallest, and it's when you will get the freshest food. The food vendors will be happy to see you because they will know people are readying themselves for some tasty food in the future.
Bring chairs: Bringing blankets is fine, but you also will want to bring a chair and set yourself in the shade if it's sunny or in the middle of the stage field if it's not too bad out there. Chairs are the great equalizer, and if you think you are going to want to be on your feet all day you are crazy. Sitting gives you a chance to enjoy the beer and to digest the great food. And with those captain's chairs people carry around, it's easy to enjoy the day, enjoy a base camp and have a really good time.
Talk to the breweries: Talking to the people at the brewer tents is a great way to learn about beer and a wonderful way to find out what you like. The beer guys at their tents love talking about beer. If they didn't, they wouldn't be in the business and certainly wouldn't be at the festival. Don't hesitate to talk to them about what they make, what they are coming out with and where you can get their beer.
Get your tickets and have a good time: A beer festival is not for a drunken good time. It is an event that people can enjoy and enjoy safely. Be sure to keep an eye on yourself, bring all that sunscreen or light clothing you might need, wear a hat, remember your sunglasses and, of course, buy some brewery T-shirts while you are there. The good time will take care of itself if you do that.
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