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Reviews and ratings of local lawyers.
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5.0 stars 1 review
Avvo Rating: 10.0
Licensed since 1985
Vinnie Bonazzoli and his wife, Paula, reside in Swampscott, Mass. They are devoted parents to two children. Vinnie coaches youth basketball and baseball, and he is a lector at St. Thomas Aquinas Church in Nahant, Mass. His other interests include...
Practice areas & skills: Elder Law, Estate Planning, Probate
5.0 stars 4 reviews
Licensed since 1982
Review: "Attorney Marsha Kazarosian lives up to her name and more. She not only has an incredible knowledge and respect with the law but more importantly she truly cares about her clients and their rights. I have never seen or felt someone fight for my f..."
Practice areas & skills: Divorce & Separation, Discrimination, Personal Injury
5.0 stars 2 reviews
Licensed since 1994
From a family of lawyers providing counsel to families since 1928.
Practice areas & skills: Divorce & Separation, Contracts & Agreements, Litigation, Appeals
5.0 stars 7 reviews
Licensed since 1987
Specializing in Bankruptcy for over 25 years
Practice areas & skills: Bankruptcy & Debt, Chapter 13 Bankruptcy, Chapter 11 Bankruptcy, Chapter 7 Bankruptcy, Debt Settlement
5.0 stars 3 reviews
Licensed since 2004
There is a plaque on my wall which sums up my philosophy, "Don't fire unless fired upon, but if they mean to have a war, let it begin here" attributed to Captain John Parker who led a company of men at Lexington Green. In every legal matter, there...
Practice areas & skills: Criminal Defense, Child Custody
Review: "Almost all cases involving your children or separation are deeply personal and emotional, and my case was no different in this respect. Attorney Grover Hastings demonstrated her experience and understanding while still getting to the heart of the ..."
Practice areas & skills: Divorce & Separation, Family, Alimony, Child Custody, Appeals
Licensed since 2002
The Chapdelaine Law Office is a full service law firm dedicated to our clients' complete satisfaction. We are founded on principles of dedication, accessibility and results. The Chapdelaine Law Offices practices in all courts of the Commonwealth. ...
Practice areas & skills: Criminal Defense, Wrongful Death, Litigation, Medical Malpractice, Family
5.0 stars 19 reviews
Licensed since 2008
New Hampshire and Massachusetts DUI Attorney. Call today for a free consultation!
Practice areas & skills: DUI & DWI, Criminal Defense
5.0 stars 57 reviews
Licensed since 2007
Former Suffolk County Prosecutor. Criminal Defense and OUI/DWI defense expert. Free consultations.
5.0 stars 8 reviews
Avvo Rating: 9.4
Licensed since 1989
PERSONAL INJURY - millions recovered for clients in car accidents, dental & medical malpractice, pharmacy error, workers compensation, products liability, sports injuries and other accidents.
BANKRUPTCY - chapter 7 & 13 personal bankruptcies, we ...
Practice areas & skills: Personal Injury, Bankruptcy & Debt, Business


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Product Details
Factory Style Rear Roofline Spoiler by T5i®. When you want to add just a touch of high performance style, nothing beats a roofline spoiler. A roofline spoiler adds the look of speed without detracting from the car's beautiful lines. This roofline spoiler is made of quality material, it's inexpensive and it installs easily with 3M™ adhesive.
- Factory style and quality for less
- Made from ABS plastic
- Available painted or unpainted
- Installs easily with 3M™ automotive-grade double-sided tape
- Comes with everything required for installation
- Spoiler backed by a lifetime warranty
- Paint guaranteed for 3 years
Give your car the classy, understated high performance look with this Factory Style Roofline Spoiler. This spoiler will enhance your car's styling without becoming the center of attention. It will complement and blend in with your car's fluid lines, improving the appearance of the entire vehicle.
The Factory Style Rear Roofline Spoiler is made of strong and durable ABS plastic. ABS plastic is impact, chemical and heat resistant, and widely used by the Original Equipment automobile Manufacturers (OEMs) for body panels. It's a high quality material with superior fit and finish compared to alternatives like polyurethane and fiberglass.
Each spoiler is custom designed for the application, to ensure a flawless installation. This spoiler is secured with 3M™ automotive-grade double-sided tape and comes with everything required for installation, including detailed instructions.
And although it can be ordered unpainted, we strongly encourage you to select the painted option. Our computerized paint mixing system enables us to guarantee that your spoiler will match your factory paint, and it's unlikely that a local body shop will be able to paint your spoiler for less than the price difference.
The Factory Style Rear Roofline Spoiler is backed by a limited lifetime warranty. The paint is warranted for 3 years, not including normal wear and tear.98.53 267.20
T5i® is a leading provider of quality aftermarket and performance accessories. The company markets an extensive line of spoilers, each of which is made from durable and damage resistant ABS plastic, the same material used by automobile manufacturers for original equipment body components. T5i spoilers come with everything necessary for installation, including detailed instructions, and the company is so confident in their quality that every spoiler is backed by a lifetime warranty.Product Reviews (32)
Every Customer can leave a review about our service and the product that was purchased. In order to leave your review for your new product, please follow the link in the email you receive after completing your purchase. You can rate appearance, ease of installation, price/value and product quality.T5i® - Factory Style Rear Roofline SpoilerAverage Rating: 4.5 of 5APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITYShow Next 10 Shop Now(5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2009 Mercedes E class | Posted by Marion | (Warner Robins, GA)
Spoiler was sent to an incorrect address, contacted customer support and they had a new order placed, received part in a few days. Perfect paint match, installed easily, car looks great!Was this review helpful for you? YesNoShare this review:(5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2009 Toyota Matrix | Posted by Brad | (Tulsa, OK)
We received the painted spoiler and was very easy to install. Very pleased.Was this review helpful for you? YesNoShare this review:(3.8)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2008 Scion xB | Posted by Philip | (Tyler, TX)
The spoiler had to be repainted to match my car. That was successful but took a while and several communications to achieve. The product looks good now that it is installed. The lack of adequate installation instructions made this the worst part of this experience. There is a video but it isn't of a car like mine. I had to figure it out on my own and it was very tricky to not mess it up. The fact that the foam gaskets were already installed on the spoiler made it difficult to accurately locate the drill points. I had to oversize the holes and there is a slight "popping" sound if you move the spoiler a bit by hand.Was this review helpful for you? YesNoShare this review:(4.5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2008 Scion xB | Posted by Nick | (Osprey, FL)
Very nice aftermarket spoiler at a great price. Ordered unpainted and used SEM black trim paint. Black looks great on a white XB. Installation was somewhat difficult with one person but with patience, you will get it right the first time! You have to make sure you line up the spoiler and drill you holes in just the right spot. Best to have a helper during install to assist in positioning the spoiler and taping down the drill template taps included. Note: Use masking tape over the entire corner areas you will be drilling. It will prevent scratching the paint when positioning the spoiler and this will happen if you don't use the tape.Was this review helpful for you? YesNoShare this review:(3.8)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2007 BMW 5-Series | Posted by Elbert | (Midlothian, VA)
I must admit that the roofline spoiler looks great in pictures but this one is just ok. The quality is great, however the conture lines don't quite match, it rises a little high at the roof line. This is an ok product but for the price, i don't think it's quite worth it. You will be better off paying for the trunk spoiler.Was this review helpful for you? YesNoShare this review:(4.8)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2011 Mercedes E class | Posted by Scott | (Carmel, IN)
Looks great! Easy to install! Everything as promised!Was this review helpful for you? YesNoShare this review:(5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2002 BMW 7-Series | Posted by Steve | (Mansonville, QC)
Looks great, fits very well, came with double sided tape already installed, and best of all was a small fraction of the cost of an original AC Style spoiler. 100% satisfied!!!Was this review helpful for you? YesNoShare this review:(4.5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2004 Chrysler PT Cruiser | Posted by Michael | (West Palm Beach, FL)
Perfect color match . Easy to install. Price was a little high, delivery time was perfect!Was this review helpful for you? YesNoShare this review:(4.5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2010 Honda Fit | Posted by Mervin | (Orlando, FL)
Decent fit, sanding and pre-paint prep required. Minute plastic imperfections but was expected, easy to fix.Was this review helpful for you? YesNoShare this review:(4.5)APPEARANCEEASE OF INSTALLATIONPRICE/VALUEQUALITY2013 Kia Sorento | Posted by Kyle | (Los Angeles, CA)
I received my spoiler within 2 days of ordering. The paint was a perfect match. Spoiler was packed very well. The instructions that came with it were for a 'trunk rear spoiler', not the top. Had some difficulty understanding directions. After we figured it out and drilled the holes, it went on perfectly.Was this review helpful for you? YesNoShare this review:
Product Reviews (32)
Product Reviews (32)
More Accessories
You will never pay more with CARiD! Not only will we match prices from any competitor's website or other reputable source, we will continue to honor that promise for up to one year after your purchase.
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We're car and truck enthusiasts, just like you! And it's enthusiasts we hire in our Sales and Service Centers. Many of our staff are ASE certified and have spent years in the retail auto business.
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Our huge database is regularly cross-checked to keep it current and optimized. At times, our thoroughness makes our data even more accurate than our suppliers! This rigorous process means that you can always order with confidence.

subset: commoncrawl


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Vince Gill Professes Love for Taylor Swift, Explains Why She's Undeniable
After taking the stage together at the 2013 Awards, Vince Gill is sharing his true feelings about pop-country crossover Taylor Swift.
After taking the stage together at the 2013 Awards, Vince Gill is sharing his true feelings about pop-country crossover Taylor Swift.
George Strait is out now on the 'Cowboy Rides Away Tour,' his final tour before he retires from the road. Probably, the closest he will get to us in the Tri-State is Louisville, Kentucky on March 7th at the KFC Yum Center with Vince Gill! Tickets go on sale Friday, October 11th at 10am, but we have your tickets before you can buy them!
Vince Gill was worked up when he took to the streets to confront members of the Westboro Baptist Church on Sunday (Sept. 8). The group was set up outside his concert venue to protest what they called adultery by the singer.
George Jones was laid to rest today, after a huge outpouring of support from friends, family, and fans in Nashville at the Grand Ole Opry House. I found myself glued to the TV watching the huge number of friends that spoke and sang about Jones. One performance really captured the admiration of the country legend.
Up-and-coming country singer Janelle Arthur paid tribute to one of her earliest influences on 'American Idol' Wednesday night (April 17), performing the Vince Gill classic 'When I Call Your Name' to effusive praise from the judges -- except one.
The groups Grammy Nomination for Best Country Duo/Group Performance may have been the first time you heard their name, and that's fine. That sure was the first time I heard about them.
Lights, camera, action! Kip Moore and Vince Gill are getting ready to jump offstage and on-camera for an appearance on the hit show 'Nashville...
Josh Turner prevails once again in the Country Whuppin', narrowly taking down the new one from The Band Perry. Now he goes for win number four against the new song from Kelly Clarkson with guest vocals from Vince Gill!
We had a great time hanging out with Curb recording artist, Rachel Holder in the WKDQ studio today. Check back soon for an exclusive performance, but in the meantime, check out her video for her debut single, "In Your Arms," and the cool moment we talked about, when she got to sing with Vince Gill at the age of 15.
Being asked to become a member of the Grand Ole Opry is the highlight of any country artist's career. Not everyone receives this invitation even though they may be asked to play the Opry from time to time.
Miss Piggy was having a lot of fun flirting with Vince Gill at the 'CMA Country Christmas' special on ABC on Thursday night. Piggy and Vince Gill's steamy performance of 'Baby It's Cold Outside' ended in a PG-13 rated makeout session … with Amy Grant, Vince's wife watching from offstage.


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Dec 31
full schedule at: rickodonovan.com
Aug 15
Aug 12
http://rickodonovan.com Celtic. Was in Socorro a couple of years ago thanks to Denise and Terry
Aug 10
Mar 16
Label: slam-colour records
Manager: Jane McKee @ janesworldentertainment.com
Lucky Sevens, Lucky You…
Americeltic is what happens when you get an Irish Yankee with a hammered dulcimer, mandolin, mandocello, guitar and a voice to sing gritty original folk music mixed with traditional. A regularly touring artist with a very new take on acoustic music.
A rollercoaster rid...See Full Bio
"It is Donovan's songwriting that is the real star here. This Is Not The Night is as strong as anything I've heard. "These are not your friends, this is not your town, and this is not the night" sings Donovan to bouncy folk melody that keeps running around your head long after the song is over. Lucky Sevens, the title cut, brings a harder edge as Donovan goes electric. But instead of an electric guitar break, the hammered dulcimer provides an amazingly perfect instrumental. "But when your 44 doing 55 on 66, then your lucky sevens somewhere down the road." Donovan's voice rings true. Lucky Sevens is a very good album. Donovan plays a swirl of strings that enchant and delight. His songwriting is literate, observational and very entertaining. He has created a unique sound on Lucky Sevens that he calls AmeriCelt. I call it pretty darn good."


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adidas Men's Michigan Wolverines Made In March Short-Sleeve T-Shirt
$22.00 $14.98 You Save $7.02 or 31%
Item # 34197676
|Members of The League get 5% back when you spend $100! (see promotion details)
Product Details
Every raving NCAA Madness fan deserves gear that's just as loud as they are. Find the perfect hats, jerseys, apparel & more... Right here at sportsauthority.com!


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|Project Name
|Price (USD)
|Project Name
|Price (USD)
|facebook style "wall" component
|Hi, I would like to have a facebook style "wall" component developed and integrated within my social...Features: I am looking for the same features as of facebook like posts, links, photos, events, status and
|PHP, Social Networking, Boonex Dolphin
|Oct 8, 2009
|Oct 8, 2009Ended
|Facebook. wall style upload page
|...com all our members come from FAcebook and refer back to facebook after they have added items for sale...sale, WE need some one to build us a Facebook Style Wall where members can Add items to the Website and...and then the items will go on the wall for discussion and comments, It could be done via a external Page
|Apr 8, 2012
|Apr 8, 2012Ended
|Facebook style wall to existing website
|...add a facebook style wall application to a social networking site. it should be a wall to wall script
|PHP, Javascript, Social Networking, Facebook Marketing
|Sep 29, 2009
|Sep 29, 2009Ended
|Facebook style wall required with comment and like functions
|I require a facebook style wall for my website. The wall will enable users to post comments (no pictures...post comments on comments. Exactly like the facebook wall. It needs to page aswell or do "Load more...it expanding to make it look like the faceboook wall and allow comments on posts and likes. So its quite
|ASP, .NET, AJAX, SQL, C# Programming
|Dec 5, 2010
|Dec 5, 2010Ended
|Finish off our Facebook style wall script
|I have half written our wall script, it needs to be finished off. Also a like / dislike button script
|PHP, Javascript, AJAX, MySQL, HTML
|Jul 6, 2011
|Jul 6, 2011Ended
|...personal profile. The third page would be the users wall (including friends posts), and the last page would...I need your expertise. I want to put a dent in facebook. Let me know the details.
|Mobile Phone, iPhone
|Dec 8, 2014
|Dec 8, 2014Ended
|Custom facebook wall for Moodle
|In-App Facebook Wall Spec We are looking to develop a customized solution using a facebook wall style... This wall will be located within our moodle-powered LMS. Requirements • One "wall" per class...exams for a class, each page should display the same wall with the same posts, moderators, notifications,
|PHP, Java, Facebook Marketing, Software Architecture, MySQL
|Mar 29, 2012
|Mar 29, 2012Ended
|PHP, Javascript, Website Design, HTML, jQuery / Prototype
|Dec 8, 2011
|Dec 8, 2011Ended
|Need just 1 MySQL query to select data for Facebook style wall
|I want to add a Facebook style wall to my website (MySQL, Php). The problem is that I don't know how...Description: When user posts something to the wall, he/she can select people who can view this post:
|PHP, Software Architecture, MySQL
|Feb 21, 2013
|Feb 21, 2013Ended
|Wall Family Chiropractic-Facebbook
|...grabbing Facebook landing page. For a High Energy Family Chiropractic Practice. (eg. Red Bull Style)
|Adobe Flash, Graphic Design, Internet Marketing, Social Networking, Facebook Marketing
|Oct 30, 2012
|Oct 30, 2012Ended
|Embedded video stream in facebook wall
|...embedded stream from justin.tv or ustream.tv in facebook wall. for example below ustream.tv and justin...justin.tv/mudtrucktv#r=-rid-&s=em" class="trk" style="padding:2px 0px 4px; display:block; width:345px;
|PHP, Video Services, Facebook Marketing, Embedded Software, Video Broadcasting
|Jan 5, 2011
|Jan 5, 2011Ended
|1000 Facebook wall likes, 1,000 fans on page
|1,000 wall likes stm 1,000 fans on page style
|Facebook Marketing,
|Feb 17, 2012
|Feb 17, 2012Ended
|Video Blog with pay-wall
|...commented on, and can be shared to social media (facebook) easily. The management interface needs to...membership wall. User accounts need to be used to access the members only section. The style of the...website should be Black/Grey/Red and use similar style and font to http://www.ufcgym.com/sherwood/ I'm
|PHP, Graphic Design, Video Upload
|Jun 6, 2014
|Jun 6, 2014Ended
|JibJab style
|I need "Jibjab style" facebook app that will enable my users to upload their picture into my video clip...be inside the facebook environment, and the result should be posted on the user`s wall. The app should...stages: User sees a cool video clip on his friends wall [or via pm]. User can upload a picture and place
|PHP, Software Architecture, MySQL, ActionScript
|May 12, 2011
|May 12, 2011Ended
|Farmville-style Facebook game
|We want to develop a FarmVille-like Facebook game. -Full requirements and game description to be...social features to be included: friends inviting, wall posting, gifts, etc. -Control panel to add/change...integration with Facebook, servers, etc Please bid only if you have experience on Facebook or online games
|PHP, Project Management, Engineering, Game Design, Software Architecture, Software Testing, Website Testing, MySQL, Anything Goes, Website Management, Game Consoles, Web Hosting
|Jul 27, 2010
|Jul 27, 2010Ended
|Facebook Wall
|...which will function like a facebook group. It will look like a facebook page as well. People can...can post and must be logged in using a facebook account. I need category filters on the page as well
|PHP, Facebook Marketing, MySQL
|Apr 24, 2013
|Apr 24, 2013Ended
|Facebook Wall
|... Go to this facebook page:? <http://www.facebook.com/amfam> I want a facebook page like this...my business. I want to have an interactive wall like the one above but for my Real Estate Business...pulls information from the companies server. Does facebook use server side scrips? I would want a flash
|PHP, Project Management, Engineering, Software Architecture, Software Testing, Website Testing, MySQL, Website Management, Web Hosting
|Dec 20, 2009
|Dec 20, 2009Ended
|Linkedin Style Wall Script
|We need a wall script with.i want a small wall script like FB or linkedin with following features and...will have same wall like FB and Linkedin. First page will be dashboard and all his old wall updates or followed...fb. we will tell and give sample design jpeg how wall share text aea will look like 2. User can share
|PHP, Website Design, Graphic Design, HTML
|Dec 2, 2013
|Dec 2, 2013Ended
|Facebook wall
|...engine 3.18 + He wall plugin v 3.26 I Need to make wall plugin exactly like facebook wall (same functions:follow...video:"are there like facebook", But need only some works. Last thing:The wall is integrated with Group
|PHP, Java, Software Architecture, Social Engine, Smarty PHP
|Feb 9, 2012
|Feb 9, 2012Ended
|need facebook wall script installed on a flash site
|I need a facebook wall style message board script installed on my site, briannaschmidt.com.au I
|PHP, Project Management, Engineering, Software Architecture, Software Testing, Website Testing, MySQL, Website Management, Web Hosting
|Dec 8, 2009
|Dec 8, 2009Ended


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Black Seed Bagel's New Spot and All the Weekly Dish
Black Seed Bagels finally opened its long-awaited East Village location Monday in the storefront that housed legendary pastry shop DiRobertis for more than a century.
Jeweled Rice Pudding for Breakfast
Garnished with a rainbow of dried fruit, nuts and spices, this rice pudding is sweet but not overly so — just right for the morning meal.
Israeli Company Channels Charles River Into New Beer
From left, Charlie Storey of Harpoon Brewery and Nadav Efraty, Rick Stover and Francesco Fragasso of Desalitech toasting their production of Charles River Pale Ale.
Einat Admony's New Eatery to Offer Sephardic Tapas
After her hometown of Tel Aviv, Chef Einat Admony's favorite city is Barcelona. "I like the simple food there," she tells the Forward. "I love the atmosphere and the way they eat."
Is the Lower East Side Ready for the Apple-Cinnamon Bialy?
The Lower East Side storefront, pre-renovation.


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|Home | About | Journals | Submit | Contact Us | Français
Dermatofibroma is a common benign fibrohistiocytic lesion that usually appears as a slow-growing, firm dermal nodule with a predilection for the legs of middle-aged women. They are usually smaller than 2 cm in diameter. Many histological variants have been described. Generally, the clinical and histological diagnosis is straightforward, but differentiating it from other cutaneous tumors can be difficult in atypical cases and rare variants. Giant dermatofibroma is a rare clinical variant of dermatofibroma and less than 25 cases have been reported. It is characterized essentially by its unusually large size, which often mimics malignant tumors clinically. We first present the case of a giant hemosiderotic dermatofibroma in a 54-year-old patient, who presented with a large ulcerated mass of the left foot which was excised, and then review the literature briefly.
Dermatofibroma (DF; fibrous histiocytoma) is a spectrum of benign fibrohistiocytic tumors, which presents with a wide variety of clinical and histopathological features. Most measure between 0.5 and 2 cm, are often found on the limbs and trunk and can be recognized clinically by pinching the suspected nodule between the finger and thumb and observing that it is fixed within the dermis. It is usually asymptomatic, although pruritus and tenderness are not uncommon. Removal of the tumor is not necessary unless diagnostic uncertainty exists or disturbing symptoms are present. Giant DF, in contrast, is a very uncommon variant, larger than 5 cm and often polypoid, and the clinical diagnosis is obscure. We present a case of a giant DF (hemosiderotic type), in a 54-year-old patient, and review the literature on the condition briefly.
A 54-year-old patient, known to have type 2 diabetes, presented with a large ulcerated mass of the left foot. The lesion had been present for about 20 years and had initially been pea-sized. Over the last one a half years before case presentation, its size had increased up to 5 cm, and it had become painful and ulcerated. A similar 1-cm lesion was also present on the right leg (fig. (fig.1a).1a). Surgical resection of the mass and total skin graft were performed. One and a half years after surgery, the patient is well and has a healthy-looking scar with no signs of recurrence (fig. (fig.1b1b).
Macroscopic examination showed a large ulcerated cutaneous mass, measuring 5.1 × 4 × 1.5 cm (fig. (fig.2a).2a). It had a pedunculated appearance with a large circular stalk measuring 3 cm. On cut section, the mass was solid and heterogeneous with white and brown areas (fig. (fig.2b).2b). No necrosis or cysts were seen. Histological examination revealed an ill-defined dermal proliferation of elongated fibrohistiocytic cells. Cellularity was variable with hypocellular and collagenized areas alternating with more cellular areas, sometimes of storiform pattern (fig. (fig.3a).3a). Some occasional moderate nuclear atypia was seen. No mitotic activity or necrosis was found. There were some giant multinucleated (Touton-like) cells and numerous tumor cells with brown hemosiderin pigment (positive with Prussian blue stain) (fig. (fig.3b).3b). At the borders of the lesion, collagenous nodules were seen entrapped between tumor cells. There was a grenz zone between the tumor and the overlying epidermis, which was focally ulcerated. The histological diagnosis was giant hemosiderotic DF.
Typical DF are usually smaller than 3 cm. Usually, the clinical and histological diagnosis is simple, but distinguishing it from other cutaneous tumors can be difficult in atypical cases and rare variants. Giant DF is a rare clinical variant of DF which is characterized by its unusually large size. The following characteristics have been accepted for giant DF [1, 2]: (a) a size of =5 cm, (b) pedunculated appearance, (c) benign biological behavior despite its size, and (d) the same histopathological characteristics as conventional DF. If those criteria are applied, only 23 cases of giant DF have been described previously in the literature. They usually present as exophytic lesions, up to half of which are pedunculated. Most frequently, they are located on the legs, especially below the knee and on the foot, followed by location on the back [1, 2, 3]. Because of their large size, the correct diagnosis is frequently not reached from clinical examination alone, and a diagnosis of malignancy is often made. The differential diagnosis usually includes malignant lesions such as basal cell or epidermoid carcinoma, dermatofibrosarcoma protuberans or other sarcomas. However, histopathological study confirms the diagnosis by demonstrating the typical characteristics of DF. The varied histological spectrum seen in usual DF can also be seen in giant DF [4, 5]. Xanthomatous cells are present in up to half of the cases [2].
Giant DF have also been reported with atypical/pleomorphic, lipidized, granular cells [6] and combined histological characteristics [2]. Some alleged cases of giant DF reported in the literature are in fact aneurysmal DFs [7, 8]. This is another uncommon histologic variant. It is usually larger than typical DF and may show rapid growth, mainly due to the presence of numerous blood-filled cavernous cavities and hemorrhage, often within the background of a hemosiderotic DF. In our case, the macroscopic brown color and numerous hemosiderophages seen microscopically correspond to a hemosiderotic variant.
The histopathological features of several variants may also coexist in the same lesion and may correspond to different stages of the same disease. Some authors consider hemosiderotic DF a precursor lesion in the development of aneurysmal DF [9, 10]. Our case, illustrating a giant hemosiderotic DF, is in agreement with this theory. To our knowledge, only one case of hemosiderotic giant DF has been reported but has not been illustrated previously [1, 2]. Giant DF can appear de novo or secondary from a preexisting and longstanding smaller lesion [5, 8] such as was the case in our patient. The origin (reactive or neoplastic) of DF including its giant variant is still unclear and debated. Some authors think that it is neoplastic because of the persistent nature of the lesion and the fact that the proliferating cells are clonal [11, 12]. However, clonality can also be seen in reactive and inflammatory conditions, including atopic dermatitis, lichen sclerosis, and psoriasis. Because of its fibrohistiocytic nature, the persistence of the lesion is not proof of its neoplastic nature and may be partly attributed to intrinsic fibrosis which does not usually regress, as it is the case for scars; neither is the fact that some DF can be gigantesque and larger than 5 cm decisive in that question since large size and rapid growth can be seen in other reactive processes/tumors such as nodular fasciitis. It is likely that DF is a heterogeneous process. The clonal genotype found in DF with histiocytoid or predominant histiocytoid features suggests that histiocytoid cells probably represent the neoplastic component [12]. Conversely, the fibroblastic form of DF may represent a reactive fibroblastic proliferation. Alternatively, it may represent a true neoplasm whose neoplastic cell type has been obscured by a prominent reactive fibroblastic component [12]. No recurrence has been reported after complete surgical excision of giant DF.
In conclusion, we report another rare and interesting variant of giant DF, which is extremely difficult to diagnose clinically but not histologically, with an excellent clinical outcome.
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Lithium-Based Grease
37 Suppliers
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Stanvac-superon GroupVerified Supplier with TrustSEAL
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Manufacturer of high temperature lithium based grease. Also offering automotive lubricants & industrial lubricant.
No. 232 & 233, Athipet, Vanagaram Road, Ambattur Industrial Estate,
Chennai - 600058, Tamil Naduhttp://www.rampetroproducts.com/industrial-lubricants.html8373903876Chennai
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Aarna Lube Private LimitedVerified Supplier with TrustSEAL
Manufacturer & trader of lithium base grease. Also offering security hydraulic fluids, woodyard machine lubricant, pulp processing equipment lubricants, paper processing equipment lubricants, high temperature & speed grease, machine tools lubricants
G-3, Gurukutir, Vijay, Vihar Complex Evershine City, Vasai East,
Thane - 401208, Maharashtra
- Chem -Verse Consultants (India) Private Limited
Chem -Verse Consultants (India) Private LimitedVerified Supplier with TrustSEAL
Manufacturer & exporter of high speed tacky grease, heavy duty off-white grease for high load & speed. Also offering auto care products, bird repellent gel, breakthrough in maintenance, cement plants lube & chemical plants lube.
P. Box No. 6791, Plot No. 120/5, Jasud Bhavan, Road No. 24-A Sion West,
Mumbai - 400022, Maharashtrahttp://www.chemverse.in/multipurpose-grease.html9953353244Mumbai
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Vintrol Lubes Private LimitedVerified Supplier with TrustSEAL
Manufacturer & exporter of lithium grease. Also offering anti wear hydraulic oils, cutting oil, engine oil, gear oil & glass mould oils.
B - 1 - 2, Akashdeep Building, No. 26- A, Barakhamba Road, Connaught Place,
New Delhi - 110001, Delhihttp://www.vintrol.org/lithium-grease.html8376807493New Delhi
Powerzone Oil Refinery Pvt. Ltd.Verified Supplier with TrustSEAL
Manufacturer & exporter of lithium based grease. Also offering 4t-plus oils, cng oils, engine oils, gear oils & heat transfer oils.
29/35, West Punjabi Bagh,
New Delhi - 110026, Delhihttp://www.indiamart.com/powerzoneoil/lithium-based-grease.html8048079377New Delhi
Nandan Petrochem LimitedVerified Supplier with TrustSEAL
Manufacturer & trader of lithium-based grease, lithium based multi purpose grease, velvex licomol grease, velvex licom grease, velvex long life grease & velvex graphite grease.
No. 19/ A, Sita Estate, Aziz Baug Mahul Road, Chembur,
Mumbai - 400074, Maharashtra
Mount Shivalik ChemicalsVerified Supplier with TrustSEAL
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No. 298, Industrial Area - 1,
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See Lube Technologies Private LimitedVerified Supplier with TrustSEAL
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No. 30, Guru Nanak Market, Focal Point,
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Chandan Engineering Solutions Co.Verified Supplier with TrustSEAL
Trader of advanced performance lithium complex grease, heavy duty bearing grease, high temperature grease, synthetic grease, food grade greases & low temperature grease.
House No. 1085, Sadguru Society, Survey No. 207, Near Tukai Darshan, Opposite SP Infocity Post Fursungi,
Pune - 412308, Maharashtrahttp://www.cesco.in/grease.html7053137846Pune
Excel Petroleum Pvt. Ltd.Verified Supplier with TrustSEAL
Leading manufacturer & trader of lithium-based grease, grinding oil, black varnish, semi synthetic cutting oil, industrial lubricants, metal working fluids & greases.
519/528, Dheeraj Heritage, S. V. Road, Santacruz West,
Mumbai - 400054, Maharashtrahttp://www.excelpetroleum.net/automotive-grease.html8048078188Mumbai
Koyo Lubricants Ltd.Verified Supplier with TrustSEAL
We are a leading manufacturer & supplier of lithium grease. Also offering automotive grease, automotive oils, biznol 4t engine oil, biznol cng oil & biznol gear oil.
A- 19, Plot No. 44, Street No. 3, Top Floor, Laxmi Nagar,
New Delhi - 110092, Delhi
Emm Kay LubricantsVerified Supplier with TrustSEAL
Wholesaler of lithium base grease, machine oils, lubricant oil, industrial lubricants, synthetic cutting oil & synthetic oils.
C- 18/15, Shivaji Park, Punjabi Bagh,
New Delhi - 110026, Delhihttp://www.emmkaylubricants.com/high-temperature-grease.html8048078229New Delhi
Molytech Lubes Pvt. Ltd.Verified Supplier with TrustSEAL
Trader of universal industrial grease. Also offering antiseize compound and paste, food grade greases, food grade lubricants, high temperature chain oil & industrial chemicals & liquids.
Plot No. 738, Industrial Area, Phase-2,
Chandigarh - 160002, Chandigarhhttp://www.indiamart.com/molytechlubes/industrial-greases.html8447530319Chandigarh
URSA Associates (Sister Concern Of Infinity Enterprise)Verified Supplier with TrustSEAL
We are a leading trader & distributor of agip grease mu ep 2, agip grease 30. We also deal in gear oil, low temperature grease, water repellent grease, lubricants & heavy duty bearing grease from India.
No. 2, Gajanan Chhaya, No. 92, V. N. Purav Marg, Chunabhatti East,
Mumbai - 400022, Maharashtra
Shri Ram LubricantsVerified Supplier
Manufacturer & trader of lithium base greases. Also offering cutting oil, engine oil, gear oils, industrial greases & long life grease, .
526, Lal Building, Phase 1, Shahzada Bagh, Near Inderlok Metro Station,
Delhi - 110035, Delhi
Narvan EnterpriseVerified Supplier
Wholesaler & trader of mak lanthex ep 2 lithium based grease, mak platinum plus lithium based grease. Also offering all amocam oil & lubricants product & all freezol product.
No. 3, Trilok Apartment, Chawala Society, Maninagar East,
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Zahara Energy Pvt. Ltd.Verified Supplier
We are a leading exporter & trader of lithium based grease. We also deal in reclaimed base oil, lubricating oil, furnace oil, calcium grease & base oils from India.
Old No. 151/6, New No. 290/6, 2nd Floor, Mahalakshmi Apartments, Peters Road, Gopalapuram,
Chennai - 600086, Tamil Nadu
- Tribo World (LLP)
Tribo World (LLP)Verified Supplier
Specialized trader & supplier of special lithium complex grease. We also offer food grade grease & lubricating grease & food grade oil.
B-205, 3rd Floor, Viswa Prakruthi Green Woods Jakkur Plantations, Yelahanka,
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ARK Autocorp Pvt. Ltd.Verified Supplier
We are manufacturer & supplier of lithium-based grease. We also offer coolant oil, cutting oil, engine oil, gear oil & hydraulic oil.
Moolchand Tower 11, Transport Nagar,
Jaipur - 302003, Rajasthanhttp://www.indiamart.com/arkautocorp/lithium-grease.html7053117376Jaipur


text:
Translated by Arthur Machen.
own heart, and found daily opportunities of mortification and resentment. The coffee was ill made, the maccaroni not cooked in the true Italian style, the dogs had bayed during the night, he had been made to dine at a small table, the parish priest had tried to convert him, the soup had been served too hot on purpose to annoy him, he had not been introduced to a distinguished guest, the count had lent a book without telling him, a groom had not taken off his hat; such were his complaints. The fact is Casanova felt his dependent position and his utter poverty, and was all the more determined to stand to his dignity as a man who had talked with all the crowned heads of Europe, and had fought a duel with the Polish general. And he had another reason for finding life bitter--he had lived beyond his time. Louis XV. was dead, and Louis XVI. had been guillotined; the Revolution had come; and Casanova, his dress, and his manners, appeared as odd and antique as some "blood of the Regency" would appear to us of the
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My review
Original recipe yields 3 servings
Based on a 2,000 calorie dietSee full nutrition
Ready In
Couldnt find paneer, so I omitted that. Next time I will only use one chili. This was really good, even if it was a little hot!
I had this as a side dish with tandoori chicken and a few chutneys. Easy to make. Btw, Mexican queso panela is a good substitute for the paneer.
didn't have corn; used 1/3 can drained chick peas and dried fenugreek leaves instead of sugar
When I can't find the paneer I'll substitute it with whatever hard, mild, white cheese is available. I've never met anyone that doesn't love this-- IT'S THE BEEEEESSSST!


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All the latest news, analysis and opinion affecting the UK small business industry. Also reviews of the most recent products and services aimed at the small business sector.
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Firm looks to meet growing demand for virtualisation from SMEs
Firm also boosts performance with firmware upgrade
Lightweight model includes videoconferencing package and nine-hour battery life
Site provides access through a browser for remote collaboration
Forum allows local providers to buy and sell bandwidth to provide cheaper hosting
Plans could save member states money and create a level playing field for smaller contractors
Synergy between iOS and OS X Lion will help Apple penetrate the enterprise, say experts
Hardware and service bundles aimed at smaller firms
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A person who likes to smoke, and smoke anything they will. They like to get trashed on the weekends and fuck a handful of girls. However, a Khames is a very deep and morally conflicted person and often reflects on life, usually unwillingly. Khames gives grace to those who do not deserve it,and often ends up alone. But he really has a lot of friends. :)
by dancechocolate March 25, 2009


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The U.S. Supreme Court ruled 5-4 on Thursday that the National Labor Relations Board, which decides unfair labor practice cases and oversees union representation elections, lacked authority to issue decisions when it had only two members.
What will happen to almost 600 cases decided by the National Labor Relations Board from January 2008 through late March 2010 is uncertain, now that the U.S. Supreme Court has issued its 5-4 decision in New Process Steel v. National Labor Relations Board, No. 08-1457. The five justices in the majority held that the five-member board lacked authority to issue all of those decisions because it had only two members during that period. President Obama used recess appointments in March 2010 to increase the board to four members, with business groups loudly opposing one of his choices, Craig Becker.
The board decides unfair labor practice cases and oversees union representation elections. Dozens of parties that lost cases during the period filed appeals challenging the board's authority to rule with two members, and federal appeals courts issued conflicting decisions on the question, with five circuit courts ruling in the board's favor and the D.C. Circuit Court of Appeals ruling against it.
In a statement responding to the Supreme Court's decision on Thursday, the board said five more cases before the Supreme Court and 69 cases currently before federal appeals courts raise the same question, and now those cases are expected to be remanded to the board, which "will decide the appropriate means for further considering and resolving them," the statement said.
"When the board went to two members in January 2008, Member [Peter] Schaumber and I made a difficult decision in difficult circumstances," NLRB Chairman Wilma Liebman says in the statement. "In proceeding to issue decisions in nearly 600 cases where we were able to reach agreement, we brought finality to labor disputes and remedies to individuals whose rights under our statute may have been violated. We believe that our position was legally correct and that it served the public interest in preventing a board shutdown. We are of course disappointed with the outcome, but we will now do our best to rectify the situation in accordance with the Supreme Court's decision."
An analysis of the Supreme Court's decision on the SCOTUSblog from Akin Gump Strauss Hauer & Feld LLP is available here.
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10/14: Learn how to automate occupational safety data collection, management and reporting to reduce risk and cost.
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Claire T Carney LibraryMay 6Library • North Dartmouth, United States
Excellent library. Great place to study and do schoolwork.
Excellent library. Great place to study and do schoolwork.
Messed up my order again. Asked for a medium Mint Hot Choc w/ Milk because it's usually really hot. I got a regular hot chocolate without any milk and burned my tongue. Very disappointed thus time
Tip for establishment. Use the name system. I waited 10 minutes because someone took my coffee.
Excellent Staff. Remember my order as I'm a usual customer for them and were quick and efficient.
Excellent food in the Cafeteria.
Great coffee. Great service. Friendly drive-thru staff.
Good service. Always friendly staff :)
Monday - Thursday from 6pm - 9pm, a small soft serve costs $1
excellent clamp cakes ($4 for 9 cakes), clam chowder and great ice cream.
Jamaican cowboy was a great drink. A mix of Malibu Rum, pineapple and orange juice, and some of their Original Margarita. :-)
Just had my 21st Birthday dinner there last night. We had a great server and I had a really fun time. Staff are very friendly and set a very fun and exciting mood for the entire restaurant.
Staff are wonderful. Great mood and absolutely hilarious.
Good food. Great Staff and pretty good gas prices. Right off highway.
Great twin lobster dinner :-)
Beautiful beach for a beautiful day. A lot of seaweed for someone used to the Atlantic Ocean.


text:
Best of News
An Arab Israeli woman votes in Acre January 22, 2013 as Israelis... News PhotoAdult,Election,Flag,General Election,Horizontal,Islam,Israel,Israeli Ethnicity,Legislative Election,Middle East,Politics,Polling Place,Voting,Voting Booth,WomenPhotographer MARCO LONGARICollection: AFP 2013 AFPAn Arab Israeli woman votes in Acre January 22, 2013 as Israelis started to vote for the 19th Israeli general election. Polls opened on January 22 in Israel's general election, which is expected to return Prime Minister Benjamin Netanyahu to power at the head of a government of hardline right-wing and religious parties. AFP PHOTO/MARCO LONGARI (Photo credit should read MARCO LONGARI/AFP/Getty Images)


text:
Page 1
Mitophagy Selectively Degrades Individual Damaged
Mitochondria After Photoirradiation
Insil Kim1,2,* and John J. Lemasters1
Damaged and dysfunctional mitochondria are proposed to be removed by autophagy. However, selective
degradation of damaged mitochondria by autophagy (mitophagy) has yet to be experimentally verified. In this
study, we investigated the cellular fate of individual mitochondria damaged by photoirradiation in hepatocytes
isolated from transgenic mice expressing green fluorescent protein fused to microtubule-associated protein 1
light chain 3, a marker of forming and newly formed autophagosomes. Photoirradiation with 488-nm light
induced mitochondrial depolarization (release of tetramethylrhodamine methylester [TMRM]) in a dose-
dependent fashion. At lower doses of light, mitochondria depolarized transiently with re-polarization within
3min. With greater light, mitochondrial depolarization became irreversible. Irreversible, but not reversible,
photodamage induced autophagosome formation after 32–5min. Photodamage-induced mitophagy was in-
dependent of TMRM, as photodamage also induced mitophagy in the absence of TMRM. Photoirradiation with
543-nm light did not induce mitophagy. As revealed by uptake of LysoTracker Red, mitochondria weakly
acidified after photodamage before a much stronger acidification after autophagosome formation. Photo-
damage-induced mitophagy was not blocked by phosphatidylinositol 3-kinase inhibition with 3-methyladenine
(10mM) or wortmannin (100 nM). In conclusion, individual damaged mitochondria become selectively degraded
by mitophagy, but photodamage-induced mitophagic sequestration occurs independently of the phosphatidyli-
nositol 3-kinase signaling pathway, the classical upstream signaling pathway of nutrient deprivation-induced
autophagy. Antioxid. Redox Signal. 14, 1919–1928.
removal of damaged and superfluous cellular constituents.
Proteasomal degradation typically eliminates short-lived
proteins that are damaged or misfolded; whereas autophagy
removes long-lived proteins, protein aggregates, and whole
organelles, including endoplasmic reticulum, peroxisomes,
and mitochondria (9, 32). Autophagy is now categorized into
chaperone-mediated autophagy, microautophagy, and macro-
autophagy (9). Autophagy as originally defined corresponds
to macroautophagy whereby whole organelles and pieces of
cytoplasm are first sequestered into vesicles called autopha-
gosomes that then fuse with lysosomes for digestion. Thus,
the terms autophagy and macroautophagy are often used
ellular homeostasis is maintained by a fine balance
between anabolic and catabolic pathways. Together,
interchangeably, a practice followed here unless otherwise
In general, insulin and other growth factors inhibit autop-
hagy, whereas nutrient deprivation and glucagon promote
autophagy (4,41).Inthenormallife ofcells, autophagy occurs
more or less continuously to remove damaged and superflu-
ous organelles, including dysfunctional mitochondria that
couldbe detrimental tocells. Severalstudies suggest thatboth
inadequate and excess autophagy promote cell injury and
death (25, 28). Therefore, proper regulation of autophagy is
fundamental to cellular well being.
During autophagy, a novel membranous structure called
a phagophore elongates and encloses cellular components
to form a double membrane vesicle called an autophago-
some (42). Lysosomes then fuse with autophagosomes
to form autolysosomes in which lysosomal hydrolases
degrade the sequestered contents. Autophagosomes can
This work is in partial fulfillment of the requirements for a Ph.D. to I. Kim from the University of North Carolina at Chapel Hill.
1Center for Cell Death, Injury, and Regeneration, Departments of Pharmaceutical and Biomedical Sciences and Biochemistry and Mole-
cular Biology, Medical University of South Carolina, Charleston, South Carolina.
2Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
*Current affiliation: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Volume 14, Number 10, 2011
ª Mary Ann Liebert, Inc.
DOI: 10.1089/ars.2010.3768
Page 2
contain virtually any cytoplasmic element, including cyto-
solic proteins and various membranous organelles, includ-
ing endoplasmic reticulum, peroxisomes, and mitochondria
(3, 22).
In yeast, genetic screens identified a series of evolutionarily
conserved autophagy (ATG) genes that are required for au-
tophagy. The protein products of ATG genes are called Atg
proteins and are categorized according to function. For ex-
ample, a mammalian homologue of yeast Atg6, Beclin 1 in-
teracts with phosphatidylinositol 3-kinase (PI3K) to form a
complex that is involved in an initial step in autophagosome
formation (11). Microtubule-associated protein 1 light chain 3
(LC3) was then identified as a mammalian ortholog of yeast
Atg8 (15). In mammalian cells, cleavage of a 22 amino-acid
fragment from newly synthesized pro-LC3 produces LC3-I.
The concerted actions of Atg7 (an E1-like activity), Atg3 (an
E2-like conjugating activity), and Atg12–Atg5-Atg16L com-
plexes (E3-like ligase activity) conjugate LC3-I with phos-
phatidylethanolamine to produce LC3-II (5, 46). So activated,
LC3-II localizes selectively to forming and newly formed
autophagosomes even after other Atg proteins dissociate.
Thus, LC3-II is a marker of ongoing autophagy. After se-
questration, some LC3-II become entrapped on the inner
surfaces of the double-membrane autophagosomes. After
fusion with lysosomes, this LC3-II is degraded. LC3-II on the
outer surface also disappears, most likely by cleavage of the
phospholipid conjugate, and the LC3 is reutilized. A trans-
genic mouse strain was created that expresses a green fluo-
rescent protein (GFP)-LC3 fusion protein. In cells and tissues
of GFP-LC3 transgenic mice, GFP fluorescence selectively
identifies the membranes of forming and newly formed
autophagosomes (30).
Whether or not autophagy selectively targets specific or-
ganelles has been controversial. After withdrawal of peroxi-
some proliferators in the presence of protease inhibitors,
peroxisomes selectively accumulate in autophagosomes (51).
The removal of peroxisomes by autophagy is referred to as
pexophagy and occurs in yeast when methanol-containing
mediumisswitchedtoglucoseorethanol-containing medium
glycogen, but not mitochondria and other organelles, occurs
in the early postnatal period (23). Mitochondria of non-
proliferating tissues such as heart, brain, liver, and kidney
constantly turn over witha half-life of10–25days(29,36),and
recent evidence supports selective autophagic removal of
mitochondria, a process of mitophagy (16, 26, 35, 45). In
staurosporine-treated cells where apoptosis is inhibited by
caspase inhibitors, mitochondria are eliminated by mito-
phagy in a specific and regulated manner (50). In yeast, the
mitochondrial outer membrane protein Uth1 is required for
efficient mitophagy in a nutrient-poor medium, but a corre-
sponding mammalian protein has yet to be identified (21).
Also, a yeast protein phosphatase homologue, Aup1, in the
mitochondrial intermembrane space is required for mito-
phagy (45). In a recent study, parkin was recruited to mito-
chondria depolarized by treatment with carbonyl cyanide
m-chlorophenyl hydrazone, an uncoupler, to promote au-
tophagy (33). Although these data support mitophagy as a
distinctive pathway from the autophagy of other cytoplasmic
mitochondria in normal cellular physiology has not been di-
rectly documented.
To that end, we used 488-nm light to photodamage indi-
vidual mitochondria of primary hepatocytes from GFP-LC3
transgenic mice. Visible light of 400- to 500-nm excites and
damages flavin-containing proteins in mitochondria, result-
ing in mitochondrial alterations and damage by reactive
oxygen species (ROS) production (1, 2). Here, such photo-
damage depolarized and permeabilized mitochondria, which
led to PI3K-independent sequestration of individual mito-
chondria into GFP-LC3-labeled autophagosomes.
Materials and Methods
3-Methyladenine (3MA; cat. no. 08592) and wortmannin
Louis, MO). Calcein acetoxymethyl ester (AM) (cat. no.
C3100MP), LysoTracker Red (LTR; cat. no. L7528), Mito-
FluorFar Red (MFFR; cat. no M22423), and tetramethy-
lrhodamine methylester (TMRM) (cat. no. T668) were
obtained from Invitrogen/Molecular Probes (Carlsbad, CA).
Collagenase A (cat. no. 11088793001) was obtained from
Roche (Penzberg, Germany).
Hepatocyte isolation and culture
Hepatocytes from GFP-LC3 transgenic C57BL/6 mice or
C57/BL6 wild-type mice were isolated by collagenase per-
fusion and cultured overnight in 5% CO2/95% air at 37?C on
of 300,000 cells per plate in Waymouth's MB-752/1 growth
medium supplemented with 27mM NaHCO3,10% fetal bo-
vine serum, 100 nM insulin, and 100nM dexamethasone
(WM) (13). For nutrient deprivation-induced autophagy, he-
patocytes were placed in Krebs-Ringer-HEPES buffer (in mM:
115NaCl, 5KCl, 1CaCl2, 1KH2PO4, 1.2MgSO4, and 25Na-
HEPES buffer, pH 7.4) plus 1 (M glucagon (KRH/G).
Loading of fluorophores
Hepatocytes isolated from GFP-LC3 transgenic mice were
loaded with red-fluorescing TMRM (200nM) or far red-
fluorescing MFFR (200nM) for 30min in the absence or
supplemented with 25mM Na-HEPES buffer, pH 7.4. TMRM
and MFFR are membrane-permeable monovalent cations that
accumulate electrogenically into mitochondria (52). In other
experiments, acidic compartments were labeled with LTR
(500nM) under identical conditions. After TMRM, MFFR, and
LTR loading, one-third of the initial loading concentration was
maintained in the medium to maintain a steady-state. Hepa-
tocytes isolated from wild-type mice were loaded with LTR as
just described. Subsequently, the cells were photoirradiated
and loaded with 1mM calcein AM for 10min at 37?C to assess
mitochondrial inner membrane permeabilization. After LTR
and calcein loading, one-third of the initial LTR loading con-
centration was maintained in the medium.
Photodamage and confocal microscopy
Laser-induced photodamage and confocal microscopy
were performed with a Zeiss LSM 510 Meta NLO laser scan-
ning confocal microscope (Carl Zeiss, Thornwood, NY) using
a 63·N.A. 1.4 oil-immersion planapochromat objective lens.
Page 3
To induce photodamage, selected areas of individual cells
containing 5–10 mitochondria were exposed to 488-nm argon
laser light at 100% power for times of 80, 160, 320, 640, and
1280ms per pixel. Green (GFP-LC3), red (TMRM and LTR),
and far red (MFFR) fluorescence was excited by the 488, 543,
and 633-nm laser lines, respectively, of argon and helium-
neon lasers in the multitracking mode. To image green and
red fluorescence simultaneously, emitted light was separated
by a 545-nm dichroic mirror and directed to different photo-
nm (red) long-pass filters. To image green, red, and far-red
fluorescence simultaneously, emitted red fluorescence was
additionally separated by a 635-nm dichroic mirror and di-
rected to different photomultipliers through 565- to 615-nm
(red) and 650- to 710-nm (far red) band-pass filters. For serial
imaging at about one frame a minute, laser illumination was
attenuated to less than 0.1% transmission power for pixel
dwell times of 3.2ms. Temperature on the microscope stage
was maintained at 37?C.
Photodamaged mitochondria are selectively
removed by mitophagy
To investigate possible mitophagy after photodamage to
mice were first loaded with TMRM, a red-fluorescing fluor-
ophore that labels polarized mitochondria and is released on
mitochondrial depolarization. Selected areas of hepatocytes
containing 5–10 TMRM-loaded mitochondria were exposed
to 488-nm argon laser light at 100% transmission for 80, 160,
320, 640, and 1280ms. This illumination was, respectively, 2.5,
5, 10, 20, and 40·104times greater than the power of illumi-
nation used for imaging. These pixel powers were designated
area photoirradiation, confocal images of red TMRM and
green GFP-LC3 fluorescence were collected every minute for
up to 120min. After lower laser photoirradiation (at or below
2·), mitochondria released TMRM, indicating depolariza-
tion, but subsequently recovered TMRM fluorescence (Fig. 1,
double arrow). This transient depolarization signified re-
versible photodamage. At higher laser power (above 2·),
mitochondria became irreversibly depolarized, indicating
permanent mitochondrial damage (Fig. 1). At 16·power,
adjacent mitochondria surrounding the illuminated mito-
chondria also became depolarized (Fig. 1, arrow). Pre-
sumably, this bystander injury was due to free radical
generation by regions of the hepatocytes actually exposed to
light (1). Overall, these data showed that photoirradiation
with 488-nm laser light caused sustained mitochondrial de-
polarization in a dose-dependent fashion. Nonetheless, the
photoirradiated hepatocytes remained viable and healthy
with no morphological evidence of injury, necrosis, or apo-
ptosis (e.g., cell surface blebbing, chromatin condensation,
nuclear lobulation) over the time course of the experiments.
At 32–5min after photoirradiation (4·and up), GFP-LC3
fluorescence began to associate with depolarized mitochon-
ring structures (autophagosomes) (Fig. 2, bottom right panel).
However, GFP-LC3 did not localize to mitochondria that
in a dose-dependent manner after expo-
sure to 488-nm light. Hepatocytes iso-
lated from GFP-LC3 transgenic mice were
loaded with 200nM TMRM for 30min.
Regions of the TMRM (red)-loaded hepa-
tocytes were exposed to different amounts
of 488-nm light at 100% power at 2.7, 5.5,
11, 22, and 44·104times greater than the
pixel illumination used for imaging. These
illumination powers were labeled in as-
cending order as 1·, 2·, 4·, 8·, and
16·. The circles represent areas of photo-
irradiation. Images of red TMRM and
green GFP-LC3 were collected before
(baseline) and every minute after photo-
irradiation. Loss of TMRM fluorescence
indicated depolarization of mitochondria.
Thedouble arrow
TMRM loss after photodamage at 1·.
The arrow illustrates TMRM loss from the
mitochondria just outside the zone of
illumination at 16·. GFP-LC3, green
fluorescence protein fused to microtubule-
associated protein1 light chain 3; TMRM,
tetramethyl rhodamine methyl ester. (To
see this illustration in color the reader is
referred to the web version of this article
at www.liebertonline.com/ars).
Mitochondrial damage occurs
Page 4
transiently depolarized after low light exposure. Unlike nu-
trient deprivation-induced mitophagy (19), GFP-LC3-labeled
cup-shaped phagophores did not grow around and sequester
individual mitochondria; rather, GFP-LC3 began to decorate
the surface of the photodamaged mitochondria (Fig. 2).
Photodamage-induced mitophagy is independent
of TMRM loading
To determine whether light-induced mitophagy is depen-
dent on the presence of TMRM as a photosensitizer, small
regions of GFP-LC3 hepatocytes were exposed to 488-nm il-
lumination at 16·laser power in the absence of TMRM. Si-
milar to observations in the presence of TMRM, the region
exposed to 16·laser power became decorated by GFP-LC3
after about 27min (Fig. 3). The GFP-LC3 fluorescence subse-
quently coalesced into green rings indistinguishable from the
GFP-LC3 rings that formed after photodamage in the pres-
ence of TMRM. Thus, mitophagy after photoirradiation with
488-nm light occurred independently of TMRM, which is
consistent with only weak absorbance of 488-nm light by
TMRM (Fig. 3). In another experiment, hepatocytes were
loaded with TMRM and subjected to photodamage with dif-
ferent doses of 543-nm laser light, a wavelength that is ab-
sorbed by TMRM. Green excitation light at 543-nm caused
photobleaching of TMRM (Fig. 4, top right panel). However,
GFP-LC3 did not localize to the mitochondria that were ex-
posed to 543-nm light (Fig. 4, bottom panels). Taken together,
these observations indicate that 488-nm light induces mito-
chondrial photodamage that leads to mitophagy. The pres-
ence of TMRM did not sensitize the process.
Photodamages induces the mitochondrial
permeability transition
Photoirradiation generates ROS that can induce the mito-
chondrial permeability transition (MPT) in mitochondria (14).
During the MPT, mitochondria become permeable to mole-
cules up to 1.5kDa, which causes mitochondrial depolar-
ization. To investigate a role for the MPT in initiating
photodamage-induced mitophagy, hepatocytes from wild-
type mice were loaded with TMRM, exposed to 488-nm light,
and then loaded with calcein AM. Calcein AM enters the cy-
tosol (and nucleus) where esterases release green-fluorescing
calcein free acid, which outlines mitochondria as round dark
voids. When mitochondria undergo the MPT, calcein fluores-
cence fills the voids (27, 37,38). After exposure to 488-nm light,
mitochondria released TMRM transiently at lower doses and
permanently at higher light levels (Fig. 5, compare top and
middle left panels). Subsequently, after loading with calcein
AM, polarized mitochondria excluded the green-fluorescing
probe. By contrast, depolarized mitochondria that had been
exposed to high power light (16·) filled with calcein imme-
diately (Fig. 5, lower panels), but mitochondria exposed to in-
mitophagy. A TMRM-loaded GFP-LC-3 hepatocyte was ex-
posed to 16·illumination, as described in Figure 1. The circle
indicates the area of photoirradiation. The arrow indicates
first localization of GFP-LC3. The double arrow illustrates
GFP-LC3 ring formation. (To see this illustration in color the
reader is referred to the web version of this article at
Photodamaged mitochondria are degraded by
of TMRM. GFP-LC3 hepatocytes were exposed to 488-nm
light at 16·relative power. The circles indicate the area of
photoirradiation. (To see this illustration in color the reader
is referred to the web version of this article at www
Photodamage-induced mitophagy is independent
Page 5
termediate power (8·) released TMRM within about a minute
but only took up calcein after several minutes more (data not
shown). Over time, however, all mitochondria irreversibly re-
leasing TMRM became filled with calcein fluorescence (Fig. 5).
At 1·power, mitochondria recovered TMRM fluorescence
afterdepolarizing initially.Thesemitochondriadidnottakeup
calcein (Fig. 5, bottom panel). Thus, photoirradiation with
higher doses of 488-nm light led to inner membrane permea-
bilization, which is the hallmark feature of the MPT.
Photodamage-induced mitophagosomes
undergo acidification
In general after autophagic sequestration, autophagosomes
fuse with lysosomes and acidify. To investigate acidification
of mitophagosomes (autophagosomes containing mitochon-
dria), GFP-LC3 transgenic hepatocytes were loaded with
MFFR, a far red-fluorescing fluorophore that accumulates
electrophoretically into polarized mitochondria like TMRM
(40). MFFR-labeled mitochondria were photodamaged with
488-nm light at 16·power, and then red-fluorescing LTR, a
weakly basic fluorophore that accumulates into acidic com-
partments, was loaded. After photodamage, mitochondria
released their MFFR fluorescence signifying depolarization
(Fig. 6, top panels). After 20min, LTR started accumulating
panel), and GFP-LC3 (green) particles began to decorate the
photodamaged mitochondria (Fig. 6, middle right panel, ar-
row). Red LTR fluorescence progressively intensified after-
ward (Fig. 6, bottom panels). Thus, after photodamage,
the structures strongly acidified.
Photodamage-induced mitophagy activates
downstream of PI3K signaling
3MA,the classical inhibitor of autophagy, and wortmannin
block autophagy after nutrient deprivation by inhibition of
class III PI3K (8, 43). To illustrate this effect of 3MA, GFP-LC3
hepatocytes labeled with TMRM were incubated in complete
growth medium (WM) or KRH/G with and without 3MA. In
WM, GFP-LC3-labeled rings and disks were rarely observed
(Fig. 7A, left panel). By contrast, after incubation of hepato-
cytes for 120min in KRH/G, GFP-LC3-labeled structures
increasedmarkedly, including
containing TMRM-labeledred-fluorescing
green-fluorescing rings
phagy. TMRM (red)-loaded GFP-LC3 hepatocytes were
exposed to different amounts of 543-nm light at 100% power–
5.5, 11, 22, and 44·104times higher than the power used for
imaging. These pixel powers were labeled in ascending or-
der as 2·, 4·, 8·, and 16·. The circles represent the areas
of irradiation. Images of red TMRM and green GFP-LC3 were
collected every minute before (baseline) and after photo-
damage. (To see this illustration in color the reader is re-
ferred to the web version of this article at www.liebert
Exposure to 543-nm light does not induce mito-
photodamage. Hepatocytes from a wild-type mouse were
loaded with TMRM and exposed to 488-nm laser light at
relative powers of 1·, 2·, 4·, 8·, and 16·, as described in
Figure 1. Images were collected before (baseline) and after
photoirradiation. After exposure, hepatocytes were loaded
with 1mM calcein acetoxymethyl ester for 10min, and images
of red TMRM and green calcein fluorescence were collected.
The circles indicate areas of photoirradiation. (To see this il-
lustration in color the reader is referred to the web version of
this article at www.liebertonline.com/ars).
Inner membrane permeabilization occurs after


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