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How to: the Marc Jacobs Dot-Inspired Polkadot Manicure
Mon, 13 August 2012 1:17PM
Marc Jacobs' new scent Dot was the inspiration behind today's manicure. For those of you who didn't catch our What to Buy This Week, here's a little refresher of the fragrance flacon. So cute.
Zoning in on the fact that you can find inspiration for your manicure from everywhere, from clothing, makeup and the great outdoors, here's a how-to on the Marc Jacobs Dot manicure. I've stuck with the red and black colour palette, but this would also work equally as well in other colours.
Step 1:
Paint a thin coat of base coat.
Step 2:
Once your base coat is dry, depending on your chosen red nail polish, paint 1-2 coats on each nail, save for your ring finger. I used Sally Hansen Complete Salon Manicure in Right Said Red, $16.95, from Priceline.
Step 3:
Then, add 1-2 coats of black nail polish on your ring finger, like OPI Nail Polish in Black Onyx, $19.95, from David Jones.
Step 4:
Using the bottom of a bobby pin broken in half, dip into the black nail polish, wipe any extra polish on the edge of the bottle, and scatter the small black dots across your nails. I would recommend practicing a few times on a piece of paper first, just so you can gauge how much polish you'll need on the pin.
Quick tip: Once you have the hang of it, try to work as quickly as you can so the nail polish doesn't dry out, and also so the polish doesn't cake on the pin. If you're out of bobby pins, toothpicks also work a treat!
Step 5:
Repeat step four using the red nail polish and bobby pin for your ring finger nail (the one painted black).
Step 6:
Wait for your nails to thoroughly dry, as the dots are a little thicker than a regular coat of polish. Then, add a coat of high-shine top coat – I used Sally Hansen Diamond Shine Base and Top Coat, $16.45.
Ta-da! Here's the final product, with the Limited Edition 30ml EDP, $75, from David Jones and Myer:
What do you think, Primpettes? Love a good polkadot manicure? Have you tried this before?
If so, did you use a bobby pin?
What other colours would you try it with?
Posted by: Hayley Bennett (Google+)


text: Sisaundra Lewis - Oh Sherrie (The Voice) by Free Britney at April 29, 2014 5:35 am. Comments Sisaundra Lewis goes for broke on Steve Perry's "Oh Sherrie" on The Voice Top 10 show. Share Tweet Email Edit Delete Follow The Voice? Facebook Disqus Tag: The Voice Related Videos: The Voice Videos Uploaded by: Free Britney Uploaded: April 29, 2014 Duration: 151 seconds

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Brazil's Straw Hat project helps women leave abusive situations
A look at Switzerland's entrenched gun culture
Inside Story | 28 Feb 2013 08:09 GMT | Politics, Bulgaria, Greece, Italy, Spain
The results of Italy's elections are in, and there is perhaps even more uncertainty than there was before the vote began.
"The big majority of Italians wanted a different kind of Europe, not a Europe of austerity but a Europe that could help the countries to have another kind of prosperity and I think that all the protests that we see in Europe, in Bulgaria, in Spain, in Greece, and now in Italy show that Europe has to pay attention to this kind of situation."
- Pier-Virgilio Dastoli, the president of the European Movement in Italy
The dramatic election failed to produce an outright winner and now sworn enemies must consider working together to avoid more economic woes.There has been an angry backlash over austerity measures which has thrown Italy into political turmoil.Tired of the same old politics and politicians, Italians have instead thrown their support behind the grassroots campaign of one-time comedian Beppe Grillo.His Five Star Movement has become the largest single party in the country by campaigning on a non-party platform.According to election results, of the 630 seats of the Chamber of Deputies, or Lower House, the centre-left grouping of Pier Luigi Bersani won just over 29 percent of the vote - but in doing so, gained a huge advantage.To make sure the largest party gains a majority, it is automatically awarded 340 seats, if it has less than 55 percent of the vote.
"What is bad for financial markets is not necessarily bad for country and people .... Now the real essence of this election is the significance of Beppe Grillo and I think its significance runs far beyond Italy. It speaks to a lot of the politics that is developing throughout Europe .... Both parties, the governing parties in Italy are not giving what voters want ... so voters have gone elsewhere."
- Thomas Palley, a senior economic policy adviser AFL-CIO
Silvio Berlusconi's centre-right coalition was just 0.4 of a percent behind and so was awarded 124 seats as a direct proportion to the number of votes.Meanwhile, Beppe Grillo's Five Star Movement became the biggest single party - with just over 25 percent and 108 seats.And the centrist coaltion of former Prime Minister Mario Monti won just 10 percent of the vote, and 45 seats.And a look at the results for the 315 seats in the Senate or Upper House sjows that Bersani's coalition won 31 percent of the vote, taking 113 seats.Berlusconi's 12-party bloc took 30 percent, but won 116 seats because of a regional bonus. Grillo's Five Star Movement won 23 percent, and 54 seats. And Monti's bloc took 9 percent and 18 seats.
So, what does the uncertain election outcome mean for the future of Italy and the eurozone?Inside Story, with presenter Kamahl Santamaria, discusses with guests: Pier-Virgilio Dastoli, the president of the European Movement in Italy; Alberto Nardelli, an Italian affairs analyst; and Thomas Palley, a senior economic policy adviser to the American Federation of Labor and Congress of Industrial Organizations (AFL-CIO).
"Silvio Berlusconi's party did as polled, the impact of that number is much bigger because of the way the senate regional voting system works. The big story is the collapse in the centre-left support ... because if you actually look at the numbers, Berlusconi was predicted to get about 28 to 30 percent of the votes, which is more or less what he got. What happened is the big collapse in centre-left support and the rise of Beppe Grillo, I think that's what caused the outcome in terms of seats."
Alberto Nardelli, an Italian affairs analyst
Source: Al Jazeera
As Italians vote, we ask who do they trust to take on the financial crisis in Europe's third-largest economy.
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Full CoverageBreaking News
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Crews are at the scene of a fire in an empty commercial building in Quincy early Tuesday morning.
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Lenovo EasyCamera is used by 97,620 users of Software Informer. The names of program executable files are amcap.exe, lvcfpswx.exe, LXBCCXY.exe, MyCam.exe, NotificationsViewHost.exe, PCMService.exe, R.I.C.Setting.exe, RsCap.exe, svcreg.exe, tvsu.exe, VeriFace.exe, LPS.exe, LiveCa07.exe, BisonCap.exe, Camera.exe, CTCamSuite.exe, Easycapture.exe, EasyRecovery.exe, fbset.exe, FPApp.exe, GameConsole.exe, go_ez.exe, HD-RunApp.exe and Yoga Phone Companion.exe. This particular product is not fit to be reviewed by our informers.
Graham Dean 4 years ago— MRTT Author reports...Pros: It's wonderfull but I am a tad biased!Cons: None at all
My website is easiest found by searching for MRTT Model, full address http://homepage.ntlworld.com/mrtt.support/ The software shows model railway operators and the public what trains are about to run - and lots more. Current version 18.104.22.168, freely dowloadable. Runs Win98 onwards. Downloaded version can run any MRTT file, but is limited in file save size. This resriction removed for £10!
Graham Dean August 2011
Stephen Marks 4 years ago
I could not get it to upgrade, neither from my previous version, or by going to there sight. Says the download que does not exist?
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Poor women also are more likely to be abused by their partners, and their exposure to stress worsens physical and mental health. Such exposure affects infant health in negative ways as children suffer from physical diseases, trauma and even lower IQs due to stress in utero.
Thankfully, local, county-level policing policies have been effective in reducing intimate partner violence. Because of these reductions, fewer women have been medically treated for assault. While this policy targets women, Currie and Aizer writes, it has the added benefit of helping newborn health.
Family Planning
Another big area of concern is access to care and family planning. Poor women are more likely to have unplanned pregnancies and pregnancies that are closer together, the researchers write. However, recent work shows how Medicaid expansions of coverage for family-planning services have helped lower birth rates and multiple pregnancies. While such policies haven't improved infant health, per say, they've benefited mothers while influencing children's longer-term outcomes.
Future Research
Overall, poor mothers benefit from programs and policies both before giving birth and after. But often women only become eligible for these programs after the baby is born, creating a potential time gap in services.
"Given the research on the importance of prenatal conditions, such policies are potentially missing a major window of opportunity," said Currie.
Early-education programs have especially been shown to improve long-term outcomes for low-income children. Intervening early before a child is three years old
|Contact: B. Rose Huber
Princeton University, Woodrow Wilson School of Public and International Affairs


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Sense to refresh its brand next year to get rid of 'dated' perception
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The proposed cap on tax reliefs create a "huge disincentive" for anyone to give more than a quarter of their income to charity, and so is effectively a tax on giving, according to the vice-chair of Charity Tax Group.
Kevin Russell, who is also technical director at Christian donor advised fund Stewardship, says that the more detail that emerges about the policy, the worse it gets.
He said that one item of confusion that was cleared up by the clarification note published by the Treasury on Tuesday is that gifts above £40,000 will be potentially caught by the cap, rather than those above £50,000 as many in the sector had assumed. This is because it is the gross gift that is subject to the cap, not the net gift.
"So it's actually slightly worse than we thought," Russell said.
Something else that was not in the note but has emerged from discussions with HMRC is the fact that the cap will essentially penalise anyone who gives more than 25 per cent of their income to charity.
Russell explained: "Because the basic rate of tax that a charity claims is protected, the Revenue has said people can still give more than 25 per cent of their income, they just won't get the tax relief for the excess. But if they give a sum such that the amount of basic rate tax that the charity reclaims exceeds the total relief that they are permitted, under the cap, to claim, then not only will the relief be restricted but the donor will get a tax assessment from the Revenue and will have to pay up.
"In that sense it has become a tax on giving," he said.
"So while the government in the clarification note states that 'tax reliefs exist to support a range of policy objectives, promoting activities such as philanthropy' – this policy doesn't promote or support philanthropy at all, it's actually a huge disincentive.
"It says 'we want to encourage you to give up to 25 per cent of your income to charity but we don't want to encourage you to give away any more'.
"They also say in the note that they are going to 'ensure this change does not significantly impact on charities which depend on large donations'. I'm not sure how they are going to ensure that without making carve-outs that make a mockery of their policy intention."
And it is not just large gifts that may be impacted, Russell warned. "If a donor gives, say, £5,000, or even £500, to a local charity under gift aid, that could still be subject to the cap if the donor is also giving substantial and numerous donations to other charities in the same year, such that overall the cap is exceeded. So, which donations will the donor cut out to stay within the cap? It may well be those small local ones which the donor is less committed to, as well as shaving back the major gifts."
Russell also claimed the scheme fails to recognise that a lot of large donations go to donor advised funds like Charities Aid Foundation, Stewardship and community foundations, all of which make grants to small charities on the back of the gifts that they receive from major donors.
"It may be that a number of small charities will close as a result of this policy. I remain very concerned, I don't think it's good policy and it should be scrapped."
John Low, chief executive of the Charities Aid Foundation, said: "We knew the tax changes would be bad, but this confirms our worst fears. The Treasury talks as if Britain's most generous charitable donors are simply tax avoiders.
"The government's handling of this has been shambolic. Far from clarifying matters, it has created further confusion among charities and donors. That's no way to fulfil its vision of a Big Society."
Separately, David McHattie, head of charities at Barclays Corporate, warned that the uncertainly caused by the proposed cap is likely to disrupt donations this year even before the measure is actually implemented, and advised charities to take action immediately.
He said: "For those charities reliant on major donors the impact cannot be underestimated.
"Charities need to start working closely with their major donors now, exploring their plans and understanding the likely effect on each donor individually if the legislation goes ahead, as some will be more impacted than others. This can then be factored into budgets and forecasts for this year and beyond."
Support for the Give It Back George campaign has snowballed since it was launched by NCVO and CAF two weeks ago. At the time of publication it had attracted the backing of more than 1,850 organisations and individuals.
Adrian Beney
More Partnership
5 Apr 2012
I agree with Kevin - this is quite awful, and it doesn't just affect the very very wealthy. It affects the generous, and this is shameful.
Our FAQs as we can see them, and for what they are worth to anyone on this are at http://biy.ly/GIBGeorge
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Budget 2012: Tax relief cap could strangle major gifts, charities warn
Government's own philanthropy figurehead urges PM to scrap cap on tax-effective giving
Donors or dodgers? - the tax relief cap saga so far
13 Oct 2015
Disability charity Sense plans to unveil a new brand early next year in a bid to shake off its old fashioned...
12 Oct 2015
Islamic Relief Worldwide saw its income rise to almost £100m in the year to December 2014, with a surge...
12 Oct 2015
Rules on gift aid and benefits given to donors are too complex and in need of reform, charity tax and...
13 Oct 2015
NCVO and Acevo have agreed to work more closely together to promote the positive impact of the voluntary...
13 Oct 2015
Rob Wilson, the minister for civil society, has given clear backing to charities' right to campaign...
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Catch22, a charity working with disadvantaged people, has today announced that it has acquired criminal...
2 Oct 2015
The MS Society has written to approximately 25,000 of its web users to warn them their personal information...
1 Oct 2015
Social media giant Facebook has apologised to the Royal National Institute for the Blind after it lifted...
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Pennies, a micro-donation tool, has announced that it has now collected over 20 million donations through...
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It is nice to have a scope when hunting yotes in open country.
You are heading the right direction by getting with folks in your area as there is much to learn from the locals.
This is a discussion on Coyote hunting in Arizona within the General Firearm Discussion forums, part of the Related Topics category; Hey guys. Ive been thinking about trying out predator/coyote hunting. Ive just started researching it the last week or so and I'm trying to find ...
Hey guys. Ive been thinking about trying out predator/coyote hunting. Ive just started researching it the last week or so and I'm trying to find a good group to join or others that are willing to share their experience and knowledge. My hunting experience has been all bird hunting for dove, quail, and pheasant while growing up in Kansas. I have no experience with calling or hunting predators but think it could be a great thing to learn and share with my son.
I found the arizona predator calling group is in my area and looks like a good starting point. They have monthly meetings and looks like they even have novice hunts to help newbies. Just wanted to see if anyone else here knew of any groups or training in the East valley. Also my only rifle currently is a colt le6920 and I was not sure if that would work if I should look into a dedicated hunting rifle?
It is nice to have a scope when hunting yotes in open country.
You are heading the right direction by getting with folks in your area as there is much to learn from the locals.
21 years and 21 days, United States Marine Corps.
The line of hard men willing to rain violence on our enemies so you can sleep warmly and safely in your bed at night continues. That's what we do. Semper fi.
NRA Life Member since 1972
I think the Colt would work fine, probably with a scope of some sort. They are really just skinny dogs with a mean streak.
Your gun is probably fine for starting out, given some decent hunting ammo. Probably better if it's scoped or has a smallish (1-2 MOA) dot if you're using an RDS.
I think a lot depends on the terrain you're hunting and the cover it provides. If the 'yote smells you or sees you moving and assumes you're a threat, he won't get close enough to take a humane (= placed with confidence) shot without magnifying optics. What part of AZ do you plan to hunt?
NRA Endowment Member
NROI Chief Range Officer
No plans on where I would hunt. I'm in east mesa and willing to travel but based on the amount of coyotes I see running around out here I would guess that there could be decent hunting in the vicinity. I would have no problem taking a trip south or north if needed. What magnification do you think would be appropriate for a scope for coyote hunting?
I'm just starting to look into this. I just recently got my colt and still need to get proficient with it first. Aside from a 22 it's my first rifle I've owned. I shot rifles here and there growing up but pretty much all my hunting experience is with shotguns.
I have a .22-250 that I "dedicated" to coyote hunting because that's about all I would really be hunting with it over here in Maine. That being said I haven't put coyote hunting high on the list of priorities. (duck and deer are way ahead, they're must tastier)
Either way, I feel a good 3-9x scope would do well for you. Maybe 4-12x if you're feeling giddy. For a 16" barreled AR I don't think you'll need any more than that because I wouldn't expect to be reaching wayyy out there with it. I have an AR with a red dot that I let friends use when we go out so they can take closer shots if they present themselves. I'm in no way calling myself a good coyote hunter either.
My ARs are set up for defensive work so I'll defer to those who hunt with them to recommend a scope. If pressed, I'd say 3-9 x 40 should be adequate for 'yotes out to about 300 yards. Just don't get a cheapie BSA or NcStar; you'll never go wrong with good glass like Leupold.
NRA Endowment Member
NROI Chief Range Officer
Thanks for the info guys.
Smitty what are the distances for rifles on the public range at rio salado?
Is it for sport or what?
Luke 22:36
Then said he unto them, But now, he that hath a purse, let him take it, and likewise his scrip: and he that hath no sword, let him sell his garment, and buy one.
Freedom doesn't come free. It is bought and paid for by the lives and blood of our men and women in uniform.
USAF Retired
NRA Life Member
I've seen this show when I was getting my spray bedliner in my truck about shooting them out in the cold and sometime in the snow.
Luke 22:36
Then said he unto them, But now, he that hath a purse, let him take it, and likewise his scrip: and he that hath no sword, let him sell his garment, and buy one.
You probably already know this, but remember you do need a general hunting license for four-legged coyotes.
Unfortunately they're not issuing licenses for the two-legged variety yet.
But in all seriousness be careful, in some parts of AZ you can find Mexican wolves Mexican Wolf and Coyotes: Know the difference and if I remember correctly they are endangered and the fines for harming or killing one are rather steep.
TSgt. Lickey
It takes a college degree to break'em;
and a high school education to fix'em!


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realmagick.com The shrine of knowledge.
Gayatri Translation
A selection of articles related to gayatri translation.
Original articles from our library related to the Gayatri Translation. See Table of Contents for further available material (downloadable resources) on Gayatri Translation.
- An Essay on Sex and Sex Magick: Liber Conjunctus / Liber Two
- SEX Sex begins and ends at Conception. For those loving people who have chosen to so Conceive, the lustful Penetration, the willing Acceptance has its finale when Sperma conjuncts Ovum. The Fruit of this Union transforms the relationship that an individual...
Body Mysteries >> Sexuality
- Astral Rest & Recovery Areas
- I have visited astral rest and recovery places many times. The hospital-like scenario and atmosphere is always similar, but each room I visit is quite different. These rooms seem to reflect the life conditions surrounding patients at the time of their passing,...
Parapsychology >> Astral Projection
- OBE, Understandability & Memory Download Problems
- The mind boggles at the potential complexities of interdimensional subtle-body relationships and energetic conflicts created during OBE; most especially during wake-induced OBE. Consider the memory compatibility problems that could arise between different...
Astral Projection >> Out of Body Experiences
- Martin Luther
- Martin Luther was a German theologian, a priest and a monk, a scholar and a writer. He was the leading figure of the Protestant Reformation.
Saga of Times Past >> Biography
- You Have The Power: A Defense For Christians Doing Magick
- Recently, Pope John Paul II created a flap when he pronounced, when speaking to some visiting group, that we needed to remember that God includes both genders, and that the feminine aspect of the Deity was as important as the masculine aspect which has become,...
Religion & Philosophy >> Religions
- Themis
- (order) One of the Titans, child of Uranus and Gaea (Heaven and Earth). By Zeus, she is the mother of Dike, Irene, and others. She is the Goddess of wise counsel, and She governs law, ceremony, and the translation of Divine Will. She was oracular, and a...
Deities & Heros >> Greek
- Truth, Lies and the Holocaust
- Any fool can tell the truth, but it requires a man of some sense to know how to lie well. -Samuel Butler Over the years, I have heard many tales of tragedy and persecution committed against Neo-Pagans around the country. From folks losing jobs, losing...
Saga of Times Past >> History & Anthropology
Gayatri Translation is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Gayatri Translation books and related discussion.
Suggested Pdf Resources
- The Translation Studies Reader
- 26 Gayatri Chakravorty Spivak. 397. THE POLITICS OF TRANSLATION.
- faculty.ksu.edu.sa
- Gayatri Chatterjee
- www.allianceglobaled.org
- "This Bhaja his Bhaja his Bhajan/Devotional song book is an
- Translation – Version 2) ............................................................................... 23. Gayatri Mantra .......................................................................................................................
- www.saicenterofaustin.org
- Cultural Translation and the Exorcist: A Reading of Kingston's and
- The task of the feminist translator is to consider language as a clue to the workings of gendered agency.
- central.wmrhsd.org
- Questioned on Translation: Adrift
- Questioned on Translation: Adrift. Gayatri Chakravorty Spivak. Igave you " Afterword" to read, and you sent me questions.
- muse.jhu.edu
Suggested Web Resources
- Gayatri Mantra - Wikipedia, the free encyclopedia
- Translation.
- en.wikipedia.org
- Gayatri Mantra - The Lyrics Translation and Deep Spiritual Meaning
- The top 10 causes of Spiritual Enlightenment and how to discover your spiritual path to awakening and transcend the experience of suffering!
- www.enlightenedbeings.com
- Gayatri Mantra Meaning - Meaning of Gayatri Mantra - Translation of
- Here is given the word by word meaning of Gayatri mantra. Check out the translation of Gayathri mantra.
- www.thecolorsofindia.com
- Gayatri Mantra - Meaning and Translation
- www.tamilbrahmins.com
- Gayatri Mantra in Hindi - Meaning and Translation
- www.eaglespace.com
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Gayatri Translation Topics
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siddha siddhanta paddhati
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Californians fear cleanup may not restore site of 1959 nuclear disaster
SIMI VALLEY, Calif. — The sun was barely up at a former Cold War rocket test site when crews in hard hats, neon vests and steel-toed boots collected jars of dirt as part of an extensive effort to clean up from a partial nuclear meltdown a half- century ago.
Parties that inherited the toxic mess face a 2017 deadline to restore the sprawling hilltop complex on the outskirts of Los Angeles to its condition before chemical and radioactive wastes leached into the soil and groundwater.
For residents living downhill from the Santa Susana Field Laboratory, it would seem like a conclusion to a protracted fight. But many remain dissatisfied that a large portion of the land won't be cleaned to the highest standards.
"I don't care how long it takes, I just want it cleaned," said 62-year-old Holly Huff, whose family moved into the area a month before the 1959 nuclear accident.
The road to decontamination has been long and costly, as winding as the two-lane path to the lab entrance 30 miles northwest of downtown LA. Decades in the works, the cleanup has been complicated by the web of owners and responsible parties at the nearly 2,900-acre site.
Environmentalists and homeowners three years ago cheered when the Energy Department and NASA agreed to clean their parcels to background levels — the most stringent standard — essentially returning the land to its natural state.
But Boeing Co., which owns the lion's share, opted to follow cleanup rules drawn up in a 2007 pact requiring the site to be scrubbed to a lesser standard.
Despite the lower bar, Boeing said it's complying with cleanup expectations typical of Superfund sites. The defense contractor wants to transform its tainted section into a park and says it's doing more than necessary to meet that goal.
"We want to make planes, and that's our mission. We want to get this site cleaned up as quickly and as safely as possible," said Boeing project manager Art Lenox.
On a recent July morning, loud drills echoed from the Boeing section where workers fetched soil samples that were then transferred to stainless steel containers and placed in a cooler for later analysis.
In the area of the nuclear meltdown, another team dug into the dirt like archaeologists. The goal: determine the amount of volatile organics, heavy metals and other possible carcinogens left from the rocket testing and nuclear age.
The work, expected to continue through the end of the year, is the prelude by the three parties to sketch out their final cleanup script, which should begin in 2016.
"We're doing everything we can to keep to a 2017 schedule. It will be a hard push," said Mark Malinowski of the California Department of Toxic Substances Control, which oversees the cleanup.
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text:
updated 06/20/2012 AT 8:00 AM ET
•originally published 06/20/2012 AT 10:45 AM ET
As The X Factor's new crop of judges travels the country in search of talented singers for the competition's second season, Britney Spears has proved to be a tough judge who isn't immune to the intense moments of emotional auditions.
"I think I'm a fair judge," says Spears, 30, who spoke after the show's San Francisco stop. "Sometimes it's hard because I know what they've been through and being so young and [wanting to] achieving their dreams."


text:
GERMANY: EU challenges German "environmental" bottling laws
A German packaging regulation, covering imported bottled natural mineral water, is being challenged in the European Court of Justice by the European Commission. The German regulation of 1998 imposes a re-use scheme on importers, obliging them to ship empty packaging back to the country of origin. When bottled mineral water is brought in over long distances this can mean a heavy cost burden for importers.
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Dodge Journey Model Overview
New Dodge Journey
|$20,895 - $33,295
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Dodge Journey Questions
Master Window Switch
master window switch will not work the front windows or the power mirrors but will work the rear windows.Replace the switch but didnt help. any suggestions on the wiring harness
Does A 2009 Journey Model Se Use A Fobik-type Or Chip Key?
The dealer sold us the car with one key. When we asked for the key fob, we were told we had to get that through the parts department. The parts department said that yr/mo. doesn't use a FOBIK-style or...
Dodge Journey Locks On Its Own Without My Pressing The Keyfob?
When exiting my car my car alarm arms without my arming it with the keyfob. Through out the night I will hear the car alarm arm without being near the keyfob.
Strange Little Buttons And Light
Are these bluetooth oriented in some way? The button cluster is about 1 inch in size, located on the lower left part of my dash. Light is blue. weird
Dodge Journey Se 2010 Idle Issues
I bought a used 2010 Dodge Journey SE have had it about 5 months, had 75,000 km on it when I bought it and just put little over 6000, coding issues came up lately on dash that resulted in sensor in th...
About the Dodge Journey
The originator of the suburban minivan, Dodge has taken a while to join the crossover segment, but finally makes its entry with the 2009 Dodge Journey. Billing itself as a perfect blend of SUV, minivan, and sedan, the Journey will compete with the Ford Edge and the Nissan Murano. Falling stylistically somewhere in between these two, the Journey shares a platform with the Sebring and Avenger, but is two inches taller and five inches longer. This means the standard two row, five-person seating can expand to a 5+2 configuration, with a two-person third row bench.
The Journey's selling point will be its cargo versatility and roomy interior, with reclining rear seats, a second row that moves forward and aft, and raised seating for both second and third rows. Storage bins in the floor, glove box, cargo area, and under seat cushions, along with integrated child seats put the focus on family utility. The crossover will be offered in three trims as a front-wheel drive model, with all-wheel drive available in the performance-oriented R/T. Two engine choices range from a 2.4 I4 to a 3.5 V6, with a diesel engine available outside the U.S.
The Dodge Journey attempts to integrate all the benefits of its genre-defining Caravan minivan, but steer away from the styling stigmas. Though essentially a station wagon, Dodge adds muscular wheel flares, sporty head and taillights, and a rear spoiler to bring its people hauler into the 21st century.


text:
Brazil's Straw Hat project helps women leave abusive situations
Saudi, Iran and the 'war' over the Hajj stampede
14 Jun 2010 20:39 GMT | Sport, Football, Latin America, Italy, Paraguay
Italy got their World Cup title defence off to a stuttering start when they needed to come from a goal down to draw 1-1 with Paraguay.
The four-time champions came into the match at Green Point Stadium in Cape Town under pressure after a underwhelming build-up and they had to dig deep to salvage a point.
On a cold and wet night, the South Americans stunned Marcello Lippi's men by taking the lead on 39 minutes when Antolin Alcaraz outjumped ageing Italy captain Fabio Cannavaro and Daniele De Rossi to head home a cross.
De Rossi redeemed himself by grabbing the equaliser eight minutes into the second half, making the most of goalkeeper Justo Villar's failure to clear a corner to put the Italians back into the game.
Italy, who are often slow to start at big tournaments, turned up the heat after their goal and they could have had more, but Paraguay clung on to share the Group F spoils.
Charged down
Italy had the first sniff of goal after five minutes when the ball bounced kindly for Riccardo Montolivo who shot on the half-volley but it was charged down by Paraguayan defenders.
Lippi's team were in charge early on, making all the running and looking dangerous on the break as the rain poured down.
Vincenzo Iaquinta sent in a teasing cross but Alberto Gilardino couldn't get his head on the end of it as they ramped up the pressure.
Paraguay only started to come alive on 20 minutes, and some good build-up saw Torres have a punt from distance only to see the ball squirm well wide.
At the other end Montolivo, playing in place of injured AC Milan playmaker Andrea Pirlo, broke free down the middle but could only deliver a weak shot that went straight at the Paraguay keeper.
Iaquinta was in the action again soon after and should have done better from inside the six yard box but was hounded off the ball before Alcaraz got the breakthrough by getting on the end of a Aureliano Torres cross.
Italy came out for the second-half without veteran goalkeeper Gianluigi Buffon, who apparently had a lower back problem.
Federico Marchetti replaced him and he was busy early on with Enrique Vera going close on 53 minutes.
Italy though started to take charge and Montolivo got a shot on target before they won the corner that led to the goal.
Simone Pepe curled the ball into the box and Villar failed to connect with his punch, leaving the unmarked Di Rossi to bury it in the back of the net.
The goal proved a tonic and they went close as they pressed for the winner, with Pepe having the best chance, only to see his powerful long range drive kept out by Villar.
Source: AFP
Al Jazeera's Paul Rhys sees Slovenia beat Algeria to continue Africans' unhappy run.
Sport, Football, Algeria, Slovenia
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Enbridge Energy is eyeing a major pipeline in Minnesota state, but the project faces fierce environmental opposition.
Environment, Oil spill, Energy
Plunder of Somali waters by foreign fishing vessels could mean the return of hijackings, locals warn.
Environment, Somalia, Africa
Once-thriving northeast factories waylaid by '90s economic reforms as millions of former 'employees-for-life' laid off.
Business & Economy, Unemployment, China
Frustrated by long queues, thousands of refugees register with German authorities struggling with the recent influx.
Refugees, Humanitarian crises, War & Conflict
Armed group says four suicide bombers took part in attack that left four Emirati soldiers and at least 11 others dead.
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Alliance says Russia deliberately violated air space, as Kremlin invites Turkish officials to avoid 'misunderstandings'.
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We speak to former Israeli Prime Minister Ehud Olmert, and ask a former KGB general about Russia's air strikes in Syria.
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101 East follows the lives of seven people in Nanjing and asks what they think of the direction their country is taking.
Politics, Asia Pacific, China
In a Delhi slum, puppeteers, musicians, jugglers and acrobats try to unite as they wrangle with an approaching eviction.
Business & Economy, Arts & Culture, Poverty & Development
An investigation into the high rate of child sex abuse in Jamaica and the government's failure to protect its children.


text:
HOUSING RECOVERY AFTER A DISASTER: Getting a Roof Overhead When Everything Is Falling Down
This timely Housing Issues Forum is important for anyone making their home in Ventura County. The forum is NOT about individual emergency preparation. It will be a discussion on the impacts to the housing sector following a catastrophic disaster and some of the challenges and obstacles we may face in Ventura County after the "Big One" hits......and it will.
Who Should Attend: Building officials, city planners, HOA board members and management companies, lenders and financial institutions, community response volunteers, realtors, local residents, and individuals with a home in Ventura County.
WHEN: May 20, 2014, 11:30 a.m. to 1:00 p.m. A tasty lite lunch is served!
PANELISTS: Gil Zavlodaver, Office of Emergency Services; Ava Voss, Ventura County Red Cross; Linda Fisher-Helton, Area Housing Authority
PRESENTED BY: JDTP Law Corp. and HOME (Housing Opportunities Made Easier)
LOCATION: Ventura County Community Foundation (VCCF) Board Room, 4001 Mission Oaks Blvd., Camarillo
REGISTRATION: Professionals: $15; Income Restricted Seniors/Students: $5
This story is contributed by a member of the community and is neither endorsed nor affiliated with Ventura County Star.
Subscribe to the Ventura County Star
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
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The Motorola ZN5 is the best camera phone we've seen so far. But it doesn't stop there, as it's a good phone, too.
The social network for professionals has redesigned its digital daily in the hopes of getting members to stick around longer.
The company seems set on making business content, not social networking, the focus of the site.
Automatic Media, publisher of pioneering Web 'zines Feed and Suck.com, ceases operations, according to a notice on its Web site.
The BlackBerry Bold is finally in our hot little hands! Bonnie is in love with it, and she tells us why. Then we discuss the BlackBerry Storm and new messaging and camera phones. We also go over our latest reviews of the HTC Touch Pro, the Motorola Zine Z
Motorola and Kodak introduce the new Zine series of camera phones.
Browser-based magazines bring readability, style, and yes, ads, to online editions.
The popular culture e-zine and the extreme sports site shut down, ending one of the longest runs so far in Net publishing.
"D-zine," a new version of Disney's "Da Buzz," is set to launch later this month on the company's subscription-based Daily Blast.


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S.T. Dupont
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text:
Page 1
Erythropoietin Receptor Contributes to Melanoma Cell Survival
in vivo
Suresh M. Kumar1, Gao Zhang2, Boris C. Bastian3, Murat O. Arcasoy4, Pankaj Karande5,
Anitha Pushparajan1, Geza Acs6, and Xiaowei Xu1
1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of
Medicine, Philadelphia, PA, USA
2The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, USA
3Departments of Dermatology and Pathology, University of California, San Francisco, CA, USA
4Department of Medicine, Duke University School of Medicine, Durham, NC, USA
5Departments of Chemical and Biological Engineering, Rensselaer Polytechnology Institute, Troy,
6Departments of Anatomic Pathology and Women's Oncology, Moffitt Cancer Center, Tampa, FL,
Erythropoietin (Epo) is widely used clinically to treat anemia associated with various clinical
conditions including cancer. Data from several clinical trials suggest significant adverse effect of
Epo treatment on cancer patient survival. However, controversy exists whether erythropoietin
receptor (EpoR) is functional in cancer cells. In this study, we demonstrated that EpoR mRNA
expression was detectable in 90.1% of 65 melanoma cell lines, and increased copy number of the
Epo and EpoR loci occurred in 30% and 24.6% of 130 primary melanomas, respectively. EpoR
knockdown in melanoma cells resulted in diminished ERK phosphorylation in response to Epo
stimulation, decreased cell proliferation, and increased response to the inhibitory effect of hypoxia
and cisplatin in vitro. EpoR knockdown significantly decreased melanoma xenograft size and
tumor invasion in vivo. On the contrary, constitutive activation of EpoR activated cell
proliferation pathways in melanoma cells and resulted in increased cell proliferation and resistance
to hypoxia and cisplatin treatment in vitro. EpoR activation resulted in significantly larger
xenografts with increased tumor invasion of surrounding tissue in vivo. Daily administration of
recombinant Epo fails to stimulate melanoma growth in vivo, but the treatment increased vascular
size in the xenografts. Increased local recurrence after excision of the primary tumors was
observed after Epo treatment. Epo induced angiogenesis in Matrigel plug assays, and
neutralization of Epo secreted by melanoma cells results in decreased angiogenesis. These data
support that EpoR is functional in melanoma and EpoR activation may promote melanoma
progression, and suggest that Epo may stimulate angiogenesis and increase survival of melanoma
cells under hypoxic condition in vivo.
Correspondence should be addressed to: Xiaowei Xu, MD, PhD, Department of Pathology and Laboratory Medicine, University of
Pennsylvania, Philadelphia, PA, 19104, email@example.com.
Conflict of interest
The authors declare no conflict of interest.
NIH Public Access
Author Manuscript
Oncogene. Author manuscript; available in PMC 2012 September 29.
Published in final edited form as:
Oncogene. 2012 March 29; 31(13): 1649–1660. doi:10.1038/onc.2011.366.
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Erythropoietin; Erythropoietin receptor; melanoma; hypoxia
Erythropoietin (Epo) regulates erythropoiesis by binding to its transmembrane receptor
(EpoR) (Wu et al. 1995). EpoR activation in hematopoietic cells results in the
phosphorylation of the tyrosine kinase JAK2 and activation of ERK and PI3K/AKT
pathways (Constantinescu et al. 1999). The recombinant forms of Epo are widely used to
treat anemia associated with various clinical conditions including cancer (Arcasoy 2008).
Recent randomized clinical trials in patients with breast (Leyland-Jones et al. 2005) and
head and neck cancer (Henke et al. 2003) unexpectedly reported that Epo treatment
decreased patients survival and accelerated tumor progression. Following the reports of the
results of three additional phase III studies and a phase II trial, all suggesting a statistically
significant adverse effect of Epo treatment on survival (Blau 2007), a "black box warning"
was issued for Epo products by the United States Food and Drug Administration (FDA).
While some of these studies have been criticized based on inadequate study design and lack
of rigorous controls (Jelkmann et al. 2008). A meta-analysis of 57 studies did not find a
survival benefit of patients receiving Epo or darbepoetin, but raised the possibility of a
negative impact on survival (Bohlius et al. 2009). A more recent meta-analysis of more than
10,000 cancer patients confirmed decreased overall survival in patients treated with Epo
(Bennett et al. 2008).
The effects of Epo on non-hematopoietic normal and cancerous tissues are still poorly
understood (Noguchi et al. 2008). Previous studies have shown that EpoR expression is not
restricted to hematopoietic cells but rather, it is also expressed in a variety of other cell types
such as embryonic neural crest progenitor cells and their derivatives (Knabe et al. 2005; Tsai
et al. 2006), neurons, glial cells, endothelial cells and cardiomyocytes (Arcasoy 2008;
Okazaki et al. 2008; Tovari et al. 2008; Wright et al. 2004). We and others have previously
shown that a variety of cancer cells, including carcinomas of ovary, breast, lung, thyroid,
prostate, endometrium, cervix, head and neck (squamous), renal cell carcinoma, glioma, and
melanoma, express EpoR mRNA transcripts and protein(Acs et al. 2001; Acs et al. 2004b;
Arcasoy et al. 2002; Arcasoy et al. 2003; Arcasoy et al. 2005; Jeong et al. 2009; Lai et al.
2005; Yates et al. 2006). A number of studies suggested that Epo/EpoR may play a role in
tumor progression (Acs et al. 2004a; Hardee et al. 2007; Kumar et al. 2005; Mohyeldin et al.
2005) whereas other reports contradicted these findings (Belda-Iniesta et al. 2007;
LaMontagne et al. 2006) and thus, the role of Epo/EpoR during tumor progression is still
The current study shows for the first time that increased copy number of the Epo and EpoR
loci occurs in surprisingly high percentage of primary melanomas; EpoR is functional in a
series of in vitro and in vivo assays. These data suggest that EpoR activation may contribute
to melanoma progression.
Genomic alterations in Epo and EpoR in melanoma
We have previous shown that melanoma express Epo and EpoR (Kumar et al. 2005; Paragh
et al. 2009). To study whether genomic changes could drive increased Epo and/or EpoR
expression, we first determined the expression and DNA copy number status of Epo and
EpoR in early passage melanoma cell lines and human foreskin melanocytes using gene
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expression profiling and high-density single nucleotide polymorphism (SNP) arrays. EpoR
gene expression was detectable in 59/65 melanoma cell lines (90.1%). While no copy
number increases of EpoR were found in any of 47 cell lines analyzed by SNP, gain of Epo
was identified in 5/47 melanoma cells lines.
To correlate the results from cell lines with primary melanomas, we analyzed array CGH
(aCGH) data obtained from 130 formalin fixed paraffin embedded (FFPE) tissue samples of
primary invasive melanomas. A detail breakdown of these cases is shown in Supplemental
Figure 1. 39 samples (30%) showed gain of the Epo region on chromosome 7p22 and 32
samples (24.6%) had copy number increases at the EpoR region on chromosome 19p13.3-
p13.2. 59 cases (45.4%) showed either Epo or EpoR gain and 12 cases (9.2%) showed
simultaneous gain of both regions (Table 1). Genomic amplification of the Epo gene was
seen in 1 case. The majority of melanomas with Epo or EpoR copy number increases were
from acral or mucosal sites (Supplemental Table 1). These data indicate that Epo and EpoR
region genomic gain is common in primary melanomas.
Effects of EpoR knockdown in vitro
Three different human melanoma cells lines from different stages, including WM35 (radial
growth phase, RGP), WM793 (vertical growth phase, VGP) and 1205Lu (metastatic
melanoma), were transfected with EpoR shRNA and selected for stable expression clones
(WM35EpoRkd, WM793EpoRkd, 1205LuEpoRkd). Respective melanoma cell lines transfected
with empty plasmids were used as controls. EpoR knockdown was confirmed by
quantitative RT-PCR (Figure 1A) and western blotting (Figure 1B) using a goat anti-EpoR
(N-terminal portion of the protein) antibody. This antibody has been shown to be specific for
human EpoR (LaMontagne et al. 2006; Paragh et al. 2009). To confirm the specificity of
EpoR knockdown, we also used commercially available EpoR siRNA (Qiagen Hs EpoR 5
Cat No: S102780351) for transient EpoR knockdown. EpoR knockdown was verified by
western blot (supplementary Figure 1A) and quantitative PCR (supplementary Figure 1B).
We previously showed that Epo stimulates ERK phosphorylation in melanoma cells (Kumar
et al. 2005). To confirm the biological effect of EpoR knockdown on ERK phosphorylation,
we treated control and WM793EpoRkd with Epo and showed that Epo induced
phosphorylation of ERK was significantly decreased in EpoR knockdown cells (Figure 1C).
To avoid the influence of mutant BRAFV600E in the ERK phosphorylation assay, we used
EpoR siRNA for transient transfection in WM3211 melanoma cells which have wild type
BRAF and NRAS proteins. EpoR knockdown by siRNA also resulted in significantly
diminished phosphorylation of ERK in response to Epo (Figure 1D). The basal phospho-
ERK level was also decreased in EpoR knockdown cells suggesting that endogenous EpoR
may regulate basal ERK activation in the absence of Epo stimulation (Figure 1C and Figure
Using a Matrigel migration assay, we found that the migration capacity of melanoma cells
increased from WM35 to 1205Lu, whereas EpoR knockdown significantly decreased the
migration capacity of the most aggressive cell line 1205Lu (Figure 1E), similar to the effect
of EpoR in other cancers (Fu et al. 2009; Mohyeldin et al. 2005). We found that
WM35EpoRkd and WM793EpoRkd cell exhibited significantly decreased growth rate
compared to control cells under normoxic conditions, while no significant change was
observed in 1205LuEpoRkd during the 4-day culture period (Figure 1F). Similar results were
seen in melanoma cells with transfected EpoR siRNA (Supplementary Figure 1C).
To assess effect of chemotherapeutic agents on EpoR knockdown melanoma cells, control
WM35 and WM35EpoRkd cells were treated with Epo (5U/ml), cisplatin 100 µM, or
combination of Epo/cisplatin for 24 hours. Epo significantly inhibited cisplatin induced cell
death in the control cells but not in EpoR knockdown melanoma cells (Figure 1G). In
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addition, EpoR knockdown cells were more sensitive to cisplatin induced cell death (Figure
1G). We then examined the effect of EpoR knockdown on hypoxia tolerance of melanoma
cells by culturing these cells under 1% O2. EpoR knockdown resulted in a 60% decrease of
1205Lu cell survival compared to control cells under hypoxic conditions (Figure 1H).
EpoR knockdown in vivo
We injected WM35EpoRkd, WM793EpoRkd, 1205LuEpoRkd cells or respective control cells
subcutaneously into the flank of nude mice. Following EpoR knockdown, WM35 cells were
not able to form any xenografts in mice (Figure 2A and 2B); tumor volume of WM793 and
1205Lu EpoR knockdown cells was significantly reduced compared to control groups
(Figure 2A and 2B). During necropsy, we noticed that half of the mice receiving control
1205Lu cells developed ascites (Figure 2A), while this was not seen in any mice injected
with 1205LuEpoRkd cells. Histological examination showed that despite the xenografts
formed by EpoR knockdown cells were significantly smaller compared to control tumor
cells, there was significant amount of tumor necrosis (Figure 2C). We quantified the area of
tumor necrosis on representative H&E stained sections and found that 50.0±11.6% of the
area in 1205LuEpoRkd xenografts were necrotic whereas 32.5±13.2% of the area in control
xenografts were necrotic. However, the difference was not statistically significantly.
Metastasis of control 1205Lu cells were identified in the lymphatic vessels and internal
organs such as liver in the mice that developed ascites (Supplementary Figure 2), while
metastasis were not observed in any of the mice injected with 1205LuEpoRkd cells. We
counted the number of mitotic figures in the xenografts and found that EpoR knockdown
significantly reduced the mitotic rate in the xenografts (Figure 2D). We performed cleaved
caspase-3 staining for apoptosis by immunohistochemistry in the xenografts, and no
significant changes were identified (Supplemental Figure 2).
Constitutive EpoR activation in vitro
To further evaluate the role of EpoR in melanoma progression, we transfected 451Lu,
WM793 and 1361C melanoma cells with expression plasmids containing EpoR-R129C, a
constitutively active EpoR mutant (Pharr et al. 1993). Transfected cells were selected and
well-formed clones were isolated, expanded and screened for EpoR expression. Random
clones with increased expression of EpoR were used for further experiments (Figure 3A for
451Lu; supplemental Figure 3A and 3B for WM793 and 1361C cells). Melanoma cells
transfected with empty expression vectors were used as controls. EpoR-R129C transfected
melanoma cells exhibited increased phosphorylation of JAK2, ERK and AKT, supporting
constitutive activation of the EpoR pathway in these cells (Figure 3A). We found that
constitutively active EpoR significantly increased melanoma cell proliferation under
normoxic (Figure 3B) or hypoxic conditions (Figure 3C) in vitro. To examine the effect of
cisplatin on melanoma cells with EpoR activation, 451Lu with EpoR-R129C or control cells
were treated with cisplatin or cisplatin/Epo(5U/ml). The presence of EpoR activation or Epo
significantly inhibited cisplatin-mediated cell death compared to control cells (Figure 3D).
Constitutive EpoR activation in vivo
To study the effect of constitutive activation of EpoR in vivo, we injected melanoma cells
with EpoR-R129C or control vectors into the flanks of immunocompromised mice. As
shown in Figure 4A, expression of EpoR-R129C in melanoma cells was associated with
significantly faster growth of tumors, and the average tumor size was 3 times that of
controls. The mice were sacrificed after 4 weeks, and the xenografts were excised, weighed
and processed for histology. As shown in Figure 4B, the tumors formed by EpoR-R129C
melanoma cells were significantly larger than tumors consisting of control cells. The
xenografts formed by control cells were confined to the dermis at the inoculation site and
showed focal tumor necrosis (Figure 4C) after 4 weeks, whereas EpoR-R129C expressing
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melanoma cells invaded into the surrounding structures, such as the femoral bone (Figure
4C). To dissect the underlying mechanism, we studies the degree of hypoxia within the
xengrafts by staining the tumor sections with an antibody to CAIX, a well established tissue
hypoxia marker (Carlin et al. 2010) and quantified the staining using a modify H score
method as we previously described (Kumar et al. 2005). The CAIX expression was
significantly increased in tumors formed by EpoR-R129C cells. Nevertheless, we found that
the area with tumor necrosis was significantly smaller in the xenografts formed by EpoR-
R129C cells compared to control cells (Figure 4E), further supporting that constitutive EpoR
activation may enhance melanoma cell survival under hypoxia in vivo.
Effect of recombinant Epo treatment on melanoma growth in vivo
Since constitutive activation of EpoR increases melanoma growth, we then tested whether
exogenous Epo treatment may influence melanoma growth in vivo. To better monitor tumor
growth, we used GFP-labeled 1232Lu melanoma cells which express EpoR by RT-PCR and
western blot (data not shown). These cells were injected subcutaneously into the flanks of
nude mice. On the following day, animals randomized to the Epo treatment group started to
receive daily subcutaneous Epo injections and the control group received saline for 8 weeks.
Tumor growth was measured twice a week using a caliper. As expected, there was a
significant increase in hemotocrits in Epo treated group (Figure 5A), but exogenous Epo had
no significant effect on tumor growth in these mice (Figure 5B). After 8 weeks, the
xenografts were surgically removed, the surgical area was inspected to ensure that no visible
tumor was left, and the wound was closed. We stained the sections with antibody against
CD34, an endothelial cell marker, and found that blood vessels in the Epo-treated group
were more dilated compared to these in the control group (Figure 5C). We quantified the
vessels with open lumen and confirmed that Epo treatment significantly increased the vessel
size in the xenografts (Figure 5D). We also stained the primary xenografts with antibodies to
Ki67 and cleaved caspase-3 by immunohistochemistry and we did not found significant
difference between Epo treated and control tumors (data not shown).
After removing the primary tumor, these mice were observed for an additional 6 weeks for
local recurrence or metastasis. Three of four mice in the control group and all four mice in
the Epo-treated group developed recurrence near the previous inoculation site. In vivo
imaging was used to visualize the GFP expressing tumor cells and showed that recurrent/
metastatic tumors in the Epo-treated group were larger compared to controls (Figure 5E).
The tumor volume was measured at the end of the sixth week. Recurrent tumors were
significantly larger in the Epo treated group (Figure 5F).
Effect of Epo in angiogenesis assays in vivo
Since Epo had an effect on blood vessels in the xenografs, we then directly assessed whether
Epo induces angiogenesis. The growth factor deleted Matrigel plugs were supplemented
with VEGF or Epo. There was little new vessel formation in control Matrigel plugs
macroscopically (Figure 6A control) and histology showed little growth of vessels in these
Matrigel plugs (Figure 6B control). Angiogenesis was increased in the plugs supplemented
with VEGF (Figure 6A VEGF) and histology showed blood filled vessels in the Matrigel
plugs (Figure 6B VEGF). Angiogenesis was also increased in plugs supplemented with Epo
(Figure 6A Epo) and histology showed blood vessels in the Matrigel plugs (Figure 6B Epo).
We have previously shown that WM35 melanoma cells can produce and secrete Epo in vitro
(Kumar et al. 2005). We performed a modified Matrigel plug assay by mixing Matrigel with
WM35 melanoma cells (2×106 in 500µl Matrigel) in the presence of a blocking anti-Epo
antibody (25 µg/plug). The Matrigel mixtures were injected into the flank region of nude
mice and left in place for 9 days. The Matrigel plugs were harvested and processed for
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text:
On May 6, Combs will present 3AM, his first new scent in six years, with a high-profile appearance at Macy's in Herald Square. The fresh, citrusy juice is safe enough appeal to a broad audience, and Combs certainly has a powerful brand behind him. The exclusive promo video features Combs and his girlfriend, Cassie Ventura—both of whom pushed the envelope in a provocative new direction.
Tag - Diddy
Rappers join forces for a tribute to Micheal Brown called "Don't Shoot."
"Puff Daddy," is back on, "I Want The Love," featuring Meek Mill.
Diddy received a honorary doctorate from Howard University this past weekend, check the video for his commencement speech.
Rick Ross' sixth studio album, "Mastermind," hits stores March 4th.
src="//player.vimeo.com/video/76419959″ width="600″ height="381″ frameborder="0″ webkitallowfullscreen mozallowfullscreen allowfullscreen>
Take a behind the scenes look at Diddy's life on, "#CirocLife."
This weekend, Fabolous took a break from his "Life Is So Exciting" Tour with Pusha T to head out to Vegas for the Mayweather vs Guerrero Fight at MGM Grand. While there he caught up with a few fellow celebs, partied with Chris Brown at his birthday party and took over Diddy's Fight Night After party at the Palms. Check out the photos and video and see for yourself. [Visuals by Rome]
A preview of Diddy's upcoming documentary, "Paris Is Burning."
Follow Diddy as he goes from All Star weekend to the Oscars.


text:
Hotel Plaza Athenee
37 East 64th Street, New York City, New York, United States, 10065
- Recommended for:
- Families with younger children, Mature travellers, Seasoned travellers, Design and architecture, History, Romance
Expert review of Hotel Plaza Athenee
Originally the Hotel Alrae, the Hotel Plaza Athenee opened in New York in 1984. Like its historic namesake in Paris, the hotel has built its reputation on impeccable service, luxury and exceptional amenities. I certainly feel it lives up to expectations.
On Manhattan's Upper East Side, just a block from Central Park and many high-end retail shops.
The 142-room hotel mimics an urban European home. Rooms and suites are decked in a variety of colors from subtle yellows and greens to rich reds and browns and feature modern French furniture, Italian linens, sitting areas and desks. Some suites have hardwood floors, glass-enclosed atriums and balconies. Bathrooms are made of marble and feature Penhaligon's products. Some suites have small kitchens.
Check availability and compare prices for Hotel Plaza Athenee
The lobby was recently renovated and much care was given to restore the canvas mural that is the focal point of the ornate space.
The Arabelle restaurant serves contemporary American fare in a formal setting. The dome ceiling drew my eye immediately. Afternoon Tea is served daily and if you can't stay for dinner, this is always a real treat as the tea sandwiches are a delight. The Bar Seine lounge has an international vibe and is home to the "crystal cosmopolitan," a drink sure to impress your date.
The 24-hour fitness center was remodeled in early 2010 and features a host of equipment. The Plaza Athenee Spa is only open to hotel guests and features eastern and western beauty services.
Like its sister property in Paris, the Plaza Athenee is known for impeccable service with the right amount of formality and cordiality. The New York City property didn't disappoint.
Check availability and compare prices for Hotel Plaza Athenee
Mature travelers and anyone wanting a quiet retreat full of history.
Packages are available throughout the year including discounts for families with young children in July and August.
More information on Hotel Plaza Athenee:
- Price from:
- Type:
- Hotel
- Address:
- 37 East 64th Street, New York City, New York, United States, 10065
- Amenities:
- Business Centre, Fitness Centre, High-Speed Internet, Parking, Pets Allowed, Restaurant, Room Service
- Neighbourhood:
- Upper East Side


text:
01/01/0001, 6:30 PM to 8:00 PM
Location:Free Admission map
This guided tour of is now full and no longer taking reservations.
The Brushmark Restaurant is open for dinner from 5 to 8 pm. For reservations, call 901.544.6225 or click here.
Every Thursday is Art Open Late! Expect the unexpected, from gallery tours and artists talks to films, musical performances and art-making activities, plus Brooks Milongas by Memphis Tango every third Thursday. Museum galleries, Brushmark Restaurant and Museum Store are open until 8 pm.
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text:
DetailsNestled amongst aspen trees on the banks of Gore Creek, each unit is decorated in a unique, contemporary design, featuring high-quality appointments. Cascades on Gore Creek offer a quiet and peaceful setting along the bike path and just steps away from the main resort. Vail Cascade Resort & Spa is a complete destination resort. Resort amenities are available to all guests and include 24 hour front desk, room service, ski concierge, covered parking, shuttle service and access to Aria Spa & Club and much more.
Ski shuttle service
24-hour front desk
Dry cleaning/laundry service
Guest laundry facilities
Concierge desk
Breakfast available - surcharge
Room service
Complimentary self parking
Complimentary wireless Internet
Safe deposit box - front desk
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- A $100.00 per person change fee will be assessed per change on any deposited reservation.
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Hollywood might deliver real-world help in oil spill crisis
The ugly saga of the Gulf of Mexico oil spill has taken an unexpected twist, with two Hollywood luminaries entering the picture to offer technical expertise they developed while working on fictional movies about disasters.
Government officials met last week with director James Cameron, apparently to pick his brain about underwater filming and remote vehicle technologies, reports Matthew Daly of the Associated Press. Cameron, of course, is well known for the meticulous approach he took when filming the blockbuster "Titanic." The meeting included representatives from the Energy Department, Environmental Protection Agency, Coast Guard and National Oceanic and Atmospheric Administration, Daly reports.
Kevin Costner, meanwhile, is providing the Coast Guard and BP with technology he developed for separating water and oil, according to Juli Weiner at Vanity Fair. Costner apparently developed the centrifugal oil separator in conjunction with DOE while working on the film "Waterworld," which was something of a disaster in its own right.
"In hopes of helping contain the most recent oil catastrophe, BP and the U.S. Coast Guard will give six of the centrifugal oil separators a trial run — in other words, six degrees of oil separation," Weiner writes.
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