text:
editor's review
3 comments
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Constitutive activity in receptors and other Proteins, Part A
Edited by
- Melvin Simon, The Salk Institute, La Jolla, CA, USA
AudienceResearchers and students in cell, molecular and developmental biology
Book information
- Published: November 2010
- Imprint: ACADEMIC PRESS
Table of Contents
Section I-- Identification and Measurement of Constitutive Activity
- Constitutive activity at the cannabinoid CB1 receptor and behavioral responses Katherine E. Hanlon and Todd W. Vanderah
- Detecting constitutive activity and protean agonism at the cannabinoid-2 receptor.
- Modulation of constitutive activity of the ghrelin receptor by use of pharmacological tools as well as mutagenesis Birgitte Holst and Jacek Mokrosiński
- Assessment of constitutive activity and internalization of GPR54 (Kiss1-r).
- Assessment of Constitutive Activity in EP Prostanoid Receptors Hiromichi Fujino, Toshihiko Murayama, and John W. Regan
- α1D-Adrenergic receptors: constitutive activity and reduced expression at the plasma membrane
- Constitutive activity of the histamine H1 receptor Saskia Nijmeijer, Rob Leurs and Henry F Vischer
- Constitutive activity of somatostatin receptor subtypes
- Assessment of homologous internalization of constitutively active N111G mutant of AT1 receptor Mohiuddin Ahmed Bhuiyan and Takafumi Nagatomo
- Methods to detect cell surface expression and constitutive activity of GPR6
- β3-adrenoceptor agonists and (antagonists as) inverse agonists: history, perspective, constitutive activity and stereospecific binding. Maria Grazia Perrone and Antonio Scilimati
- Constitutive Activity of the Lutropin Receptor and its Allosteric Modulation by Receptor Heterodimerization
- Assessing Constitutive Activity of Extracellular Calcium-Sensing Receptors in Vitro and in Bone Wenhan Chang, Melita Dvorak, and Dolores Shoback
- Constitutive Activity of Neural Melanocortin Receptors.
- Measurement of Constitutive Activity of BMP Type I receptors Peter ten Dijke
- Probing the CA among dopamine D1 and D5 receptors and their mutants
- Identification of Gain-of-Function Variants of the Human Prolactin Receptor Vincent Goffin, Roman L. Bogorad, and Philippe Touraine
- Investigations of Activated ACVR1/ALK2, a Bone Morphogenetic Protein (BMP) Type I Receptor that Causes Fibrodysplasia Ossificans Progressiva
- Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations Joaquin Lado-Abeal, Leah R. Quisenberry, and Isabel Castro-Piedras
- Assessment of constitutive activity of a G protein-coupled receptor, Cpr2, in Cryptococcus neoformans by heterologous and homologous methods
- In vitro and in vivo assessment of mu opioid receptor constitutive activity. Edward J. Bilsky, Denise Giuvelis, Melissa D. Osborn, Christina M. Dersch, Heng Xu and Richard B. Rothman
- Constitutively active µ-opioid methods
- Protein Kinase Ck2 is a Constitutively-Active Enzyme That Promotes Cell Survival: Strategies To Identify Ck2 Substrates and Manipulate Its Activity In Mammalian Cells Jacob P. Turowec, James S. Duncan, Ashley C. French, Laszlo Gyenis, Nicole A. St. Denis, Greg J. Vilk, and David W. Litchfield
- Assessment of Ck2 Constitutive Activity In Cancer Cells
- Structural basis of the constitutive activity of protein kinase CK2 Birgitte B. Olsen, Barbara Guerra, Karsten Niefind and Olar-Georg Issinger font error
- Measuring the Constitutive Activation of c-Jun N-terminal Kinase Isoforms
- Measurement of constitutive MAPK and PI3K/AKT signaling activity in human cancer cell lines. Keiran S.M. Smalley
- Constitutive activity of GPR40/FFA1: Intrinsic or assay dependent?
- Constitutive activity of TRP channels: methods for measuring the activity and its outcome Baruch Minke
- Measurement of Orexin (Hypocretin) and Substance P Effects On Constitutively Active Inward Rectifier K+ Channels in Brain Neurons
- Characterization of G protein receptor kinase 4 and measuring its constitutive activity in vivo Bradley T. Andresen
- Voltage-clamp based methods for the detection of constitutively active acetylcholine-gated IK,ACh channels in the diseased heart
- Assaying Wave and WASH complex constitutive activities towards the Arp2/3 complex.
Massimiliano Beltramo, Rossella Brusa, Isabella Mancini, Paola Scandroglio, Massimiliano. Beltramo
Macarena Pampillo and Andy Videsh Babwah
J Adolfo Garcia-Sáinz, M. Teresa Romero-Ávila and Luz del Carmen Medina
Anat Ben-Shlomo, Kolja Wawrowsky and Shlomo Melmed
Balakrishna M. Prasad, Bettye Hollins and Nevin A. Lambert
Deborah L. Segaloff
Ya-Xiong Tao, Hui Huang, Zhi-Qiang Wang, Fan Yang, Jessica N. Williams, and Gregory V. Nikiforovich
Bianca Plouffe, Jean-Philippe D'Aoust, Vincent Laquerre, Binhui Liang and Mario Tiberi
Frederick. Kaplan, Petra Seemann, Julia Haupt, Meiqi Xu, Vitali Lounev, Mary Mullins, Eileen M. Shore
Chaoyang Xue, Yina Wang, and Yen-Ping Hsueh
Mark. Connor and John Traynor
Maria Ruzzene, Giovanni Di Maira, Kendra Tosoni, and Lorenzo A. Pinna
Ryan T. Nitta, Shawn S. Badal, and Albert J. Wong
Leigh A Stoddart and Graeme Milligan
Yasuko Nakajima and Shigehiro Nakajima
Niels Voigt, Samy Makary, Stanley Nattel, Dobromir Dobrev

subset: commoncrawl


text:
4 4/1 2 5,085 Sq ft Home Swimming Pool Ocean,Intracoastal
923 and 925 hillsboro mile were being sold together for $19.9 million,923 is now cs. 925 hillsboro mile is a 2 story 4br/4.5 ba home that is being sold for land value.
2 2/0 0 1,850 Sq ft CondoIntracoastal
SHORELAND Very rare offering on icw. Boaters dream beach club feel. Property has private beach and brand new boat dock slips with lifts. Two story building with one unit per floor. Very private and quiet. Beautifully bright and clean.
The real estate listing data relating to Hillsboro Beach real estate and Hillsboro Mile Homes for sale or lease on the Boca Executive Realty website comes in part from a cooperative data exchange program of the multiple listing service (MLS) in which this real estate Broker participates. The Homes in Hillsboro Beach Hillsboro Mile displayed may not be all of the properties in the MLS's database, or all of the properties listed with Brokers participating in the cooperative data exchange program. Hillsboro Beach Hillsboro Mile Homes for sale that are listed by Brokers other than this Broker are marked with either the listing Broker's name or the MLS name or a logo provided by the MLS. The Detailed listing page about such properties includes the name of the listing Brokers. Information provided is thought to be reliable but is not guaranteed to be accurate; you are advised to verify facts that are important to you. No warranties, expressed or implied, are provided for the data herein, or for their use or interpretation by the user. The Florida Association of Realtors and its cooperating MLSs do not create, control or review the property data displayed herein and take no responsibility for the content of such records. Federal law prohibits discrimination on the basis of race, color, religion, sex, handicap, familial status or national origin in the sale, rental or financing of housing. Boca Executive Realty is an equal housing opportunity luxury real estate broker representing waterfront, golf and country club homes in Hillsboro Mile Hillsboro Beach Florida. This information is not verified for authenticity or accuracy and is not guaranteed and may not reflect all real estate activity in the market. © 2006-2015 Regional Multiple Listing Service, Inc. All rights reserved.


text:
Doug Marman Babbles about Sedona Property!
Expand Messages
- Someone on A.R.E. lamented that an Eck Spiritual Center/Temple
was not established in Sedona. Doug Marman, of course, gives
his spin on this. Interesting how he talks about Darwin Gross, the
Black Magician, along with Harold Klemp, the negatively charged
mahanta who shoved Darwin out of the eck org! Here's Doug's
explanatory post which is ever so enlightening. BTW, Doug is
asking the person named Dennis to give his sources, casting
doubt on what the other poster wrote--yet another technique
in maintaining a religious meme, isn't it!! LOL!
Doug, who knows everything, wrote:
I know how you feel about Sedona. I've always loved it as well, and
enjoyed my time in the mountains all around there.
We rented a house out on Red Rock Loop Road and could see Cathedral
Rock from our back yard. I remember swimming in Oak Creek and some of
the private swimming holes around there. And I remember hiking up into
the red rock spires during the storms that blew through there.
Stunning memories.
That was one reason why I hoped Harold would find a way to keep the
spiritual center there in Sedona. I spoke recently with Patti Simpson
about this, and she felt the same way. She also owned some land out
there back then and loved it. In fact, I remember visiting Patti on
her property while we were living out there.
I think Darwin saw the same thing and this was why he agreed to accept
the land. It did seem like a spiritual center belonged there. I think
Darwin saw this and believed it. So, I don't see any deception here at
all. In fact, I think it was probably the spiritual beauty of that
area the swayed Darwin into accepting Helen's view that Eckankar
should have its spiritual center there.
But Patti pointed out something that I hadn't realized: There is no
way to split the spiritual center from the physical headquarters. In
fact, Paul gave a talk on this very subject, about the importance of
there being one center for the organization, and that it should not be
The problem was that you couldn't put the whole organization in
Sedona. It just didn't fit. Sedona was not a place to ship books from
or print them, and Harold felt that the land itself was delicate and
would not stand up to thousands of visitors every year.
And as became clear, there was a lot more going on, like undercurrents
in the water.
In the end, the way the court case went, it did seem like a clear sign
that the center should not be there. And I think Harold went to great
lengths to do the best he could for everyone, and I am amazed that he
could find a way to turn that land into a state park for everyone's
enjoyment. He certainly could have gotten a lot more money for it if
that was what he wanted.
But I have a few questions for you. You said that you found out what
was in the court records. Does that mean that you read them? Or does
this mean that someone told you what was in them?
If you read them, can you provide a link so that we can all read them?
Or can you quote some of the sections you found most revealing?
If someone told you what was in them, can you tell us who it was that
told you and why you think they were representing the court case
If you spoke to Helen's family and friends, can you tell me what their
feelings about Eckankar were in the very beginning when Helen first
started studying? Were they always opposed to Helen's involvement? Or
did they change their mind because of what happened, but originally
like Eckankar? In other words, did they tell you that they always
thought Helen's interest in Eckankar was a mistake, or did they
encourage Helen's interest in the beginning because they could see her
desire to find out more?
I think you missed my point about David Lane. I mentioned him because
you said that it was when his book came out that she started having
doubts. My point was that she was aware of Lane's material years
before this when his term paper was copied and sent around to ECKists.
Did someone tell you that it was Lane's material that caused her to
have doubts? If so, who told you this? Do you really think that Helen,
who was as well connected as anyone in Eckankar, actually never saw
Lane's term paper when it came out years earlier? If she had read it
before, why would it have caused her to have doubts when it surfaced
I never heard that Helen was having doubts before she died, and I
never heard anyone say they heard this. Helen wasn't the sort to keep
this kind of thing to herself. She was pretty outspoken. So, some of
these things you have heard just don't add up for me. Are you sure
what you've been told is accurate?
Perhaps if you could share more about your sources or how you arrived
at your information, and why you think it is true? That might help.
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text:
Oct 26, 2012
Banco Santander Brasil has launched a 2-year, $100m term loan at Libor+175bp, according...
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Oct 21 - 22, 2015 | Grand Hyatt, Playa del Carmen, México
SFLA will convene in Playa del Carmen, Mexico the most important issuers and investors from across...
Will a strong dollar deter investors from LatAm bonds?
No, the yield-hunt goes on
Yes, but only retail investors
Yes, once the Fed raises rates
We want to partner and co-invest with US companies from authorized sectors, when they are ready to operate in Cuba.
José Oro, Thomas J Herzfeld Advisors
All material is subject to strictly enforced copyright terms & conditions and cannot be repurposed or reproduced. © 2015 Latin American Financial Publications Inc.


text:
|One Bedroom
|Contact Property
|Three Bedroom
Prices, specials, features and availability subject to change.
Contact for details
The apartments at Norriton East provide ideal facilities for the single person or small family who appreciate the convenience of community living in a quiet suburban location. * This single building apartment community is ideally located, providing access to other popular suburban Philadelphia communities. Norriton East is centrally located mid-way between the King of Prussia and Plymouth Meeting Malls. The beautifully landscaped grounds are conveniently situated adjacent to nearby shopping facilities.
Our lease terms are: 3 months, 6 months, 12 months (Please note that lease terms may vary, are subject to change without notice, and are based on availability. Inquire with property staff for complete details).
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68 units
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text:
Tiffany Snsd Terbaru 2012
[Live: SMTOWN Live 2012 in LA] SMTOWN Concert Kicks Off MC by Super Junior's Leeteuk, Girls' Generation's (SNSD) Tiffany and Taeyeon
'SMTOWN Live 2012 World Tour in LA' kicks off at Honda Center.
The hosts began the night stating "It's an honor for us to perform in the US known as the center of pop music. We have been busy in each field but we prepared a lot and are excited to perform for US fans!" . ... Read more
SNSD's Yoona, Seohyun and Tiffany are to appear on 2012 Burberry Prorsum Fashion show as Korean representatives
SNSD's Yoona, Seohyun and Tiffany will visit London to participate in a fashion show.
Along with other world-famous celebrities, Yoona, Seohyun and Tiffany have been invited to attend 2012 F/W Burberry Prorsum Collection Fashion Show as Korean representatives. The event will be held at Kensington Gardens in London on February 20. . ... Read more
SNSD Yoona, Seohyun, Tiffany will attend 2012 F/W Burberry Prorsum Show
The three SNSD members will visit London for a fashion show.
According to a representative of SM Entertainment, Yoona, Seohyun, and Tiffany have been invited to attend "2012 F/W Burberry Prorsum Women's Collection Fashion Show" which will take place at Kensington Garden in London. They will be among many world-famous celebrities. . ... Read more
SNSD′s Tiffany Says Director decided on Taeyeon as Easiest Lip Synching Member
Girls′ Generation (SNSD)′s Tiffany published that Taeyeon is the maximum productive at lip synching a choice of the members.
The SNSD individuals gave the impression at the September 3 broadcast of MBC FM4U′s Kim Shin Young′s midday Song of Hope, where the members mentioned their very best angles. . ... Read more
SNSD′s Taeyeon Sheds Tears speaking About Tiffany
We knew Girls′ Generation (SNSD)′s Taeyeon and Tiffany were inseparable, yet Taeyeon currently shared just how much her fellow member manner to her.
The SNSD participants in any case exchanged their dad or mum angel gifts from their big apple town go back and forth at the September 1 broadcast of Channel SNSD, where Taeyeon presented her gift to Tiffany.. ... Read more
SNSD′s Tiffany Posts footage alongside Tom Cruise
ladies′ Generation (SNSD)′s Tiffany give theAxe officially upload Tom Cruise to her list of Hollywood celebrity interviews.
Tiffany postedA photo amongst the celebrity on her Instagram on July xxx, writing "hadA boom speaking close to @omitionimpossible five #roguenation thank you for existing soo inspiring #tomcruiseinkorea dont omit the interview on #KBS #EntertainmentRelay." . ... Read more
SNSD Tiffany to interview Tom Cruise
SNSD"s Tiffany is getting the honour to interview the world heartthrob And Hollywood big name Tom Cruise for the latter"s upcoming movie advertisement in Korea.
Tom Cruise is going to advertise his movie "challenge: very unlikely – Rogue country" in Korea And consistent alongside the movie distributor Lotte Entertainment, Tiffany is going to hang A unique interview alongside Tom Cruise on KBS2 "Entertainment Relay".. ... Read more
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women′ Generation (SNSD)′s Tiffany might exist interviewing actor Tom Cruise.
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SNSD"s Tiffany studies graffiti tagging on "middle A Tag"
on the July 24th episode of Minternet"s "middle Attack" (middle-A-Tag), Tiffany And Lee Chul Woo attempted more or less boulevard culture.
on the episode, Tiffany attempted graffiti tagging And write "Tiff" with A centre and A few outlines.. ... Read more
SNSD′s Tiffany Gets horny in latest Photo Spread
womans′ Generation (SNSD)′s Tiffany might just be our new woman overwhelm.
Tiffany is featured in the pages of MAPS′ August factor, and long past is her bubbly and playful characterlity as she plays up a more subdued, horny character.. ... Read more


text:
Hotel San Martin Cartagena
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Colombia in 11 days: Art, coffee, nature and sea
... one else had booked that tour date and I would have to pay a not insignificant additional sum for a private tour if I wanted to continue. Which, grudgingly, I did given that this was one week before I was due to start my break in Cuba and I'd already booked flights. Suffice to say, this was a rather pricey tour, though with the exception of a few snacks, drinks and taxi/train fares I ...
Bags, Back and Dinner
... a salad or fried potatoes. It was tender, juicy, and we had a fine conversation. Esther has been taking a Spanish class for two years, so her English has improved immensely since we first met her in 2013.
We were going to walk to a nearby restaurant for cappuccino and ice cream, but after we left the restaurant, Esther's husband called. He was done working and could pick her up now, so we decided to pass on the ice cream. ...
Day 5 Juvenes/Thursday
... bargaining..at last success ..a beautiful gold jersey sporting the name James across the back. Next up collector pins and T-shirts. Erin and DayDay remember a shop from yesterday and off we go. We sorta circle around once or twice and bingo there it is..the store from yesterday. Erin and DayDay both found pins and Erin found the perfect T-shirt after working the pile to get the right size and color. Now exhausted from the heat and shopping, we begin to wander out the door ...
Street Food Tour & Attempting to Have a Night Out
... I were tired, our determination to go out salsa dancing at least one night in Colombia was greater than our desire to be lame and go to bed early on a Friday night.
We chose Caf� Havana in Getsemani as it was highlighted on our New York Times sponsored 36 Hours to Spend in Cartagena video. Caf� Havana is supposedly the most famous and authentic place to listen to salsa music in the city. We knew that the music was probably not going to ...
Not a single Cartel in sight!
... that one man can use to inflict pain on his fellow man. Th architecture is beautiful and a general mix of styles. This old town has some of the most beautiful examples of colonial architecture, and thankfully they have been restored and measures have been put into place to prevent too much development in this part of the city.Our final stop was to the sort of shopping centre that you do not want to go to. I would have preferred to stay in the old ...


text:
Plan Check
Los Angeles, CA 90036
Photo: Farley Elliott
- Sun-Wed 11:30 - midnight, Thurs 11:30 a.m. - 1 a.m., Fri-Sat 11:30 a.m.-2 a.m.
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text:
Professional Services
Company Overview of 315 Ventures, Ltd.
Company Overview
315 Ventures, Ltd. provides consulting services for medical manufacturing start-ups during Mergers and Acquisition process. The company is based in the United States.
United States
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Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at firstname.lastname@example.com.


text:
REACH (Regulation (EC) No 1907/2006) is the new Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals. It entered into force on 1st June 2007 and its main obligations started applying on 1 June 2008. It streamlines and improves the former legislative framework on chemicals of the European Union (EU).
Article 13.4 of REACH Regulation (EC) No 1907/2006 requires that ecotoxicological and toxicological tests and analyses shall be carried out in compliance with the principles of good laboratory practice provided for in Directive 2004/10/EC or other international standards recognised as being equivalent by the Commission or the Agency and with the provisions of Directive 86/609/EEC, if applicable.
(N.B.: No other international standards have yet been recognized as being equivalent to GLP.)
Annex XI of REACH (GENERAL RULES FOR ADAPTATION OF THE STANDARD TESTING REGIME SET OUT IN ANNEXES VII TO X) provides for some exemptions for existing data in case that testing does not appear scientifically necessary.
For more information see also section R.4.2 (Reliability of information) in the Guidance on information requirements and chemical safety assessment.
The European Chemicals Agency (ECHA) has been established to manage and in some cases to carry out the technical, scientific and administrative aspects of REACH. It receives the pre-registrations and registrations and will co-ordinate the evaluation, authorisation and restriction processes.


text:
Come on full moon!!!
S, Mom to N (4-3-02), A (11-27-04), L (2-20-07), B (2-20-09), G (5-6-12), and Baby Boy J born 1-17-14
Karlea (24) and DLH Kyle (25) Married in '11
Amelia Hallie Eve- 10/26/11
Claire Onalee Noelle- 1/21/14
I'm due the 26th, but my mom SWEARS i will go into labor and have her tomorrow for the full moon. Now my husband is betting for Friday. Kinda wish they would be both wrong just so I can laugh. But, at this point, i'm ready for her to get out.... I tell her every morning, "You can come out today!"
Nicole + Joel
Olivia Claire 1/22/14
EDD August 25, 2015
I am 39w tomorrow and being induced at 10pm... I'm going to do a bunch of home induction stuff tomorrow to try and kickstart it myself, but either way I hope the moon helps things along!! ;)
Happily married for 11 years & SAHM of 4 great kiddos - C (10), E (8), A (2), M (7 mo.)
Platinum ( . Y . )


text:
Four out of five still feel part of a community, according to a new study by Simplyhealth.The nationwide survey says that communities are still valued and very much a part of society.
87% believe they are responsible for their community, not the police or local council. This responsibility is divided between maintaining the community environment and nurturing a healthy relationship with those living next door or in the area.
65% know their neighbours with 93% regularly engaging in general chat. The convenience of having someone living next door is evident in 28% asking to borrow something such as cooking ingredients or garden items. It is important for families to feel safe in their community and 75% have this peace of mind by allowing their children to play with their neighbour's children. 71% feel that it is safe for them to do so unsupervised.63% have access to a community hall, 52% to recreational equipment and 27% to a communal garden.
Abby Bowman for Simplyhealth comments, "Community can mean different things to different people. Through community awards we hope to find and recognise this fantastic work which makes such a difference to the lives of people."


text:
StartUpHire is the place to find Compensation Analyst jobs. Review the list of Compensation Analyst career opportunities to the left. These Compensation Analyst jobs represent some of the most rewarding careers available.
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Business Operations Foster City, CA, United States Sales Compensation Analyst Foster City, CA, United States We have an epic opportunity for you to join our fast growing team at Zuora where you can have an impact on our revenue growth as we sprint for an IPO. We offer8/11/2015 Foster City, CA Save This Job
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TubeMogul is the hottest tech company you may have never heard of. Start-ups come and go, but we've had the foresight and focus to survive - and thrive - in today's competitive ad-tech industry. Born in a UC Berkeley incubator just seven years ago, we've built the video10/5/2015 Emeryville, CA Save This Job
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Overview --- Please submit resume with position inquiry --- In this new position, the Global Compensation Analyst shall be involved in the development of a new global compensation structure for a $500M global technology company. This key role will be involved in collaborating8/29/2015 Bridgewater, NJ Save This Job
Department: HR Location: Boston, MA Purpose and Scope: Reporting to the Sr. Director, Total Rewards & Human Resources, the Sr. HRIS & Compensation Analyst is an integral part of a very hands-on and fast-paced team. This highly visible role will own data integrity, management9/14/2015 Boston, MA Save This Job
Integral Ad Science is the leading global media valuation company in the ad tech space. Integral provides buyers and sellers of digital media with data that is actionable in real time, to quantify the quality of every online ad event. We operate at a scale that is matched only by8/14/2015 New York, NY Save This Job
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G&A (Finance and Administrative) Austin, TX, United States Based in Austin, Texas, Upland Software offers a collaborative work environment full of smart, positive, and passionate people who are respected for their unique talents and empowered to do their jobs well. As a member9/22/2015 Austin, TX Save This Job
G&A (Finance and Administrative) Austin, TX, United States Based in Austin, Texas, Upland Software offers a collaborative work environment full of smart, positive, and passionate people who are respected for their unique talents and empowered to do their jobs well. As a9/17/2015 Austin, TX Save This Job
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text:
Fresh import from Atlanta. Started off as a statistician but somehow, I dont know how, got moved to computers and enjoying it since then. I am a living algorithm writing machine
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churning code .. spitting applications ... geeky I know
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umm, my big smile.
The six things I could never do without
Think outside the box. Sometimes the little things can say a lot.
there is nothing I can live without, given food and water.
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Global warming, lunch, or your next vacation… it's all fair game.
Tons of things. Dont have time to write it all out.
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working. planning work. or a movie.
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Search the Collection
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Ernest Young(1869-1952), Fellow of the Royal Geographical Society, headmaster and geographical author
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This, the fourth book in the popular Bob's Hill Series, gives good promise of being even more widely read. The "gang" are just as human, humorous and clearly individualized as ever; and while the influence of the book is good, there is no "preaching," and fun and adventure abound.
>Benny looked at me and I could see by the way his eyes were shining that he wanted to go. But Bill never likes to change his mind.
"I think we ought to vote on it," he said, "and have Pedro put it in the minutes of the meetin'."
"Shall I put it down in invisible ink," I asked, "or in the kind that shows?"
We always write our most secret doings in invisible ink, made of lemon juice, so that nobody can read about them. We don't need to read it ourselves, because we know all about it anyway. If we want to, by holding the writing up to a fire we can make the letters show.
"Write it with chalk," said Skinny, "and make the letters a foot high. This is something we want folks to know about."
"Uniforms wouldn't be so very much good," said Benny, "if folks couldn't see us with them on."
Skinny nodded his head; then took a piece of chalk out of his pocket, and commenced to mark on the clapboards, back of the sloping roof.
I thought at first that he was going to write th
Cara Devon has always suffered curiosity and im... Read more
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How can I use the sorting functions over 'real' fields in the stored objects? How can I set the field on which I want to sort by?
It seems that the following refers to the key, in my case it's a UUID, and therefore useless to sort by:
MapReduceResult result = riakClient.
addMapPhase(new NamedJSFunction("Riak.mapValuesJson"), false).
addReducePhase(new NamedErlangFunction("riak_kv_mapreduce", "reduce_sort"), true).


text:
appellate courts
Civil Litigation
I had the pleasure of meeting Christie when I worked a summer at the office. He struck me as a warm, outgoing U.S. Attorney who was very proud of the people working for him and the sacrifice they make by choosing public service over more lucrative firm life.
Rumor has it he's going to run for governor. I hope he does.
Your post is sort of slanted against Christie. The guy had little experience for the job, he was a fundraiser for Bush, but he also did a pretty good job over the last 7 or so years. He probably deserves a smidge more credit than you're giving him.
All the crooked politicians who haven't been caught yet are celebrating. Let's see who Obama chooses to replace Mr. Christie.
Agreed. He had virtually no litigation experience before becoming US Attorney. But I understand that he's done an outstanding job running the office, and is very well liked there. Also, you neglected to mention the office's prosecution of Sharpe James, former Mayor of Newark. That should be near the top of the hit list.
What another blow to the Garden State. Watch the lackey that gets put into this office now. Odds are Christie did to good of a job and rid the State of too many corrupt politicians.
Yes Christie did a good job. But the point is, he came in without the proper background in investigations, hands-dirty litigation, and in-depth knowledge of criminal law. In spite of this ... and I stress IN SPITE OF ... he nevertheless learned the ropes and performed exceptionally well.
* * *
By that same token, anyone else can come in without the typical prosecutor background and do something similar. It depends on the character of the person ... not his party, nor his background as a fundraiser, nor what job title he or she held.
At least he went to a real law school. The Bush legacy in terms of the US Attorneys he appointed will forever be tainted by the appointments of religious whack-jobs who attended Jerry Falwell University.
Amir Efrati is shocked that someone can be appointed US Attorney without trial, criminal law, or investigative experience. If he did some research, he would learn that in all administrations, these slots are political appointments that rarely have any of the skills one would think needed. That is what the permanent AUSAs are there for.
Mr Christie, you have my vote if you run for governor of NJ. I am very impressed with your record of fighting crime in NJ. However, I feel compelled to offer some unsolicited advice, and I offer it will all good intentions. Please lose some weight. At 46 yrs of age, your health is a major concern. Would your heart hold out for a term as governor? How can anyone take seriously the need to trim the economic fat from a governor who's outward appearance bespeaks greed and excess? Weather that defines you or not is irrelevant. Think about it.
susie q is way off base with her 'weight comments' what an a**.
I bought a house in NJ. That was my first property. I later found out the previous owner knew of a lot of violation pending on the property but did not take care of them. No certificate of conformity. I was coherced that everything was fine. The lawyer who represented me was their friends, He helped me in any shape of form. I want to know if it is too late after 2 years to sue anybody for the tremendous burden they put on my shoulder.
NJ is competing with south florida as corruption capital ........ ex-judges JAY SPECHLER , robert lance andrews and DAVID McCAIN are proof that THE FLORIDA BAR grooms and protects corrupt lawyers and judges .......... GENE MOSS of THE KENSINGTON pimped MOMBACH SPECHLER PROLOGIS HOLLANDER HUMAVAY .
The Law Blog covers the legal arena's hot cases, emerging trends and big personalities. It's brought to you by lead writer Jacob Gershman with contributions from across The Wall Street Journal's staff. Jacob comes here after more than half a decade covering the bare-knuckle politics of New York State. His inside-the-room reporting left him steeped in legal and regulatory issues that continue to grab headlines.
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A federal case unfolding Brooklyn may offer a solution for some ex-offenders struggling to find work because of their criminal convictions.
Law enforcement authorities in California will generally have to get a warrant from judge to compel phone and Internet companies to turn over any digital customer information.
The company that holds the rights to one of the most familiar Christmas tunes will lose ownership of the song by the time Santa Claus comes to town next year, a federal appeals court has decided.
Hillary Clinton's appearance on "Saturday Night Live" last weekend could trigger the so-called equal-time rule, the federal law that allows qualified opposing candidates to demand comparable air time.
A Florida judge is poised to unveil his plan for reshaping the state's congressional boundaries, the latest chapter in a contentious and increasingly messy effort to strip away partisan politics from redistricting.
Content engaging our readers now, with additional prominence accorded if the story is rapidly gaining attention. Our WSJ algorithm comprises 30% page views, 20% Facebook, 20% Twitter, 20% email shares and 10% comments.


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Funny Or Die
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Jon Cryer Videos, Jon Cryer Pictures, Jon Cryer Articles
The 8 Craziest Quotes from Charlie Sheen's Rant…Said by Jon Cryer
Wow. Jon Cryer's a dick.
Jon Cryer And James Corden Recreate Duckie's 'Pretty In Pink' Dance
James Corden helps Jon Cryer relive an iconic 80's movie moment.
That Troll Jon Cryer Finally Fesses Up
Sheen had this guy's number, for sure.
Jon Cryer Headlines We Wish Were Real
He's got to keep up with his costar somehow.
Celebrities at NATPE
Jack Hannah, Damian Chapa, Jennifer Tilly, Jay Leno, Jon Cryer, Charlie Sheen, Robin Leach, Mary Hart, Kato Kaelin, Tamara Henry, Steven C. Barber
Matthew Perry's Testimony (Pt.2)
POWERFUL!!! The Testimony of the Awakening of the star of the sitcom "GO ON" MATTHEW, PERRY. This is a MUST SHARE!
Out Couple!
Did you know that the sitcom Two And A Half Men also airs in Japan? Well, it does, and this is what it looks like.
The Charlie Sheen Advice Meme
Obviously Charlie Sheen has his shit together. The guy's totally WINNING in everything he does. Um...winning? So let's take his advice. Here's some pearls of...
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Follow DJ Phat Phil on Twitter.
DJ Phat Phil, aka Phil Hoffman, aka Phil the Thrill, the nerdy guy from "Behind the Scenes" is now on Twitter.
Two and a Half Men S7 – Smores
Buy the DVD at wbshop.com! For six seasons, Charlie Harper has loved 'em and left 'em. In Season 7, he gets left. TV's #1 comedy pulls a hilarious switcheroo...
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In this episode: Bill schools Hillary and Barack on the proper way to party: "What happens when an ex-President, a sitting President and a Presidential wanna...
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http://www.thenetwerk.com/ A little girl quotes Charlie Sheen!
Charlie Sheen Doll House
Sorry, couldn't resist... Episode 18 of the Doll House Web-Series. For more episodes, visit Http://FunnyorDie.com/MichaelLeeBarlin
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MILLHITS.COM brings you shocking exclusive footage of Demi Moore's collapse that sent her packing to rehab! Security cameras show two unidentified women atte...
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What happens when an ex-President, a sitting President and a Presidential wannabe share a Malibu beach house? In this episode, after Michelle kicks Barack...
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text:
The only thing better than Scarlett Johansson is a naked Scarlett Johansson.
The only thing better than Scarlett Johansson is a naked Scarlett Johansson.
Here's all the proof you need that dog is indeed man's indeed best friend.
Ever wondered how Buffy, Willow, Xander and the rest of the Scooby Gang wound up after their adventures in Sunnydale?
Better hide the kryptonite...
Michigan State University's stoic Sparty and Western Michigan University's goofy Buster Bronco made the list of the top mascots in all of college sports.
While this honor is an asterisk for the highly-successful Michigan State sports program, it just may be the best thing to happen this season for WMU.
Thanks to everyone who came out on Friday morning for the "Free Beer & Hot Wings Morning Show" live show at Rightway Auto in Wyoming!
The guys had a great time, and you guys were a big part of why it was so fun!
Producer Joe managed to screw up "Name That Blank," but everyone still had fun with it. And "Paired With An Idiot" got all the way down to Rochambeau between Joe and Free Beer.
Whether or not you've ever heard the band Stars in Stereo, you couldn't help but rock out with them on Friday night, as they opened the show for You Me at Six and Young Guns at the Stache!
Led by the amazing Bec Hollcraft, and her amazing voice, Stars in Stereo rocked the crowd pretty hard! It was very cool that so many people turned out early to check out the band, and Stars in Stereo definitely delivered for us!
The guys in Young Guns are no strangers to the United States, having toured here a few times, and played a lot of great shows with bands like Halestorm! Right now, they're on tour with You Me at Six and Stars in Stereo, and they hit Grand Rapids Friday night!
The band came by the WGRD studios before the show to talk about music, soccer...sorry, football, and the show, with Janna. They also played some songs acoustically, that you can check out here at WGRD.com.
You Me at Six is a great band from Great Britain that's become bigger and bigger overseas, and now they're crossing the ocean to bring their melodic rock to America! They've got a huge hit song on the radio right now, "Room to Breathe", and they're on tour right now with Young Guns, and Stars in Stereo.
Do the pants make the girls, or do the girls make the pants? No one knows and in the end who really cares? Yoga can be a win-win for everybody now. Gotta give a nod to our friends at E Baums World for this sweet gallery.
Kenowa Hills High School boys' soccer player Peter Brown is this week's Meijer-97.9 WGRD High School Athlete of the Week.
Second-year Knights Coach Frank Andrade almost sounds like he doesn't have enough superlatives to describe Brown.
"He excels," Andrade said of Kenowa Hills' leading scorer. "He's a great player and he's become a great leader."
Bethany Hamilton is a professional surfer, an actress and a competitive cutie.
Her story was made famous in the 2011 film "Soul Surfer." While surfing in 2003, Hamilton was attacked by a 14-foot tiger shark, which bit off her left arm. But she refused to give up on becoming a surfing star and persevered, clinging to her dream and her faith.


text:
|Numéro de publication
|Type de publication
|Numéro de demande
|Date de publication
|9 oct. 2008
|Date de dépôt
|16 juin 2008
|Date de priorité
|16 aoűt 2002
|Autre référence de publication
|Numéro de publication
|John Sherry
|Cessionnaire d'origine
|John Sherry
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Référencé par (20), Classifications (14)
|Liens externes: USPTO, Cession USPTO, Espacenet
This application is a continuation and claims priority of U.S. patent application Ser. No. 10/219,979 filed Aug. 16, 2002 and is related to an application entitled "Disintegrating Stent and Method of Making Same," Ser. No. 09/592,413, by Jonathan Stinson, filed Jun. 13, 2000, the entire contents of both applications being hereby incorporated by reference.
1. Field of the Invention
The present invention relates generally to implantable medical prostheses which incorporate an anchoring mechanism to reduce or eliminate migration of the prostheses.
2. Description of Related Art
Medical prostheses frequently referred to as stents are well known and commercially available. These devices are used within body vessels of humans for a variety of medical applications. Examples include intravascular stents for treating stenoses, stents for maintaining openings in the urinary biliary, tracheobronchial, esophageal, and renal tracts, and vena cava filters. Stents may also be used by physicians for malignant tumors. Benign tumors are seldom stented with metal platforms.
Typically, a stent is delivered into position at a treatment site in a compressed state using a delivery device. After the stent is positioned at the treatment site, the delivery device is actuated to release the stent. Following release of the stent, self-expanding stents are allowed to self-expand within the body vessel. Alternatively, a balloon may be used to expand other types of stents. This expansion of the stent in the body vessel helps to retain the stent in place and prevent movement or migration of the stent. Stents are typically composed of stent filaments.
Stents may be categorized as permanent, removable or bioresorbable. Permanent stents are retained in place and incorporated into the vessel wall. Removable stents are removed from the body vessel when the stent is no longer needed. A bioresorbable stent may be composed of, or include, biogradable material or bioresorbable material which is broken down by the body and absorbed or passed from the body when it is no longer needed.
Commonly used materials for known stent filaments include Elgiloy(R) and Phynox(R) metal spring alloys. Other metallic materials that may be used for stents filaments are 316 stainless steel, MP35N alloy and superelastic Nitinol nickel-titanium Another stent, available from Schneider (USA) Inc. of Minneapolis, Minn., has a radiopaque clad composite structure such as shown in U.S. Pat. No. 5,630,840 to Mayer. Stents can also be made of a titanium alloy as described in U.S. Pat. No. 5,888,201.
Bioabsorbable implantable endoprostheses such as stents, stent-grafts, grafts, filters, occlusive devices, and valves may be made of poly(alpha-hydroxy acid) such as poly-L-lactide (PLLA), poly-D-lactide (PDLA), polyglycolide (PGA), polydioxanone, polycaprolactone, polygluconate, polylactic acid-polyethylene oxide copolymers, modified cellulose, collagen, poly(hydroxybutyrate), polyanhydride, polyphosphoester, poly(aminoacides), or related coploymers materials, each of which have a characteristic degradation rate in the body. For example, PGA and polydioxanone are relatively fast-bioabsorbing materials (weeks to months) and PLA and polycaprolactone are a relatively slow-bioabsorbing material (months to years).
Stents may also be covered with various materials to encourage or inhibit tissue attachment to the stent. Covered stents are gaining, favor for biliary applications because they more effectively inhibit tissue attachment, intrusion, and constriction of the tract than bare stents. For example, polytetrafluoroethylene (PTFE) covered stents are desirable for removable stents because tissue attachment or in-growth is reduced in comparison to bare stent or a stent covered with textile (polyester) material. Laminated ePTFE may also be used to cover stents.
As stents are covered with material to aid in their removal, stent migration from the treatment site increases. There remains a continuing need for covered stents which include characteristics to maintain the stent in position at the treatment site. For example, stents covered with ePTFE, such as Precedent, are easily removed after a given time period, such as six months, but may not provide sufficient fixation to prevent the risk of migration during the six month period.
The present invention relates to a removable stent for providing reinforcement to a selected region of a selected body lumen including a resilient cylindrical layer. The improvement to the stent is the inclusion of at least one bioresorbably extrusion exterior from the resilient cylindrical layer for resisting migration of the stent when the stent is positioned in the selected region of the selected body lumen.
Another embodiment of the present invention includes at least one bioresorbable extrusion exterior from a resilient cylindrical layer of a temporary implantable endoprosthesis. The bioresorbable extrusion exterior to the resilient cylindrical layer resists migration of the stent when the stent is positioned in a selected region of a selected body lumen.
The present invention also includes a method of reducing migration of a removable stent which includes the steps of constructing a removable stent including a resilient cylindrical layer and placing at least one bioresorbable extrusion exterior from the resilient cylindrical layer on the stent. The removable stent is then positioned and expanded within a body lumen. Migration of the stent is resisted by the interaction between the at least one biosorbable extrusion and the body lumen.
We first briefly describe the drawings.
The present invention improves the fixation characteristics of removable stents by incorporating bioresorbable or bioabsorbable barbs onto the removable stent or a covered stent to anchor the stent during the service life of the stent.
An implantable prosthesis or stent 101 according to a preferred embodiment of the present invention is illustrated generally in
Referring again to the preferred embodiment of
Removable stent 101 is shown in its expanded or relaxed state in
According to one embodiment of the invention, removable stent 101 may be a radially and axially flexible tubular body having a predetermined diameter that is variable under axial movement of the ends of the body relative to each other. Removable stent 101 may be composed of a plurality of individually rigid but flexible and elastic thread elements or filaments 102, each of which may extend in a helix configuration along a longitudinal center line of the body as a common axis. The filaments 102 may define a radially self-expanding body. The body may be provided by a first number of filaments 102 having a common direction of winding but axially displaced relative to each other, and crossing a second number of filaments 102 also axially displaced relative to each other but having an opposite direction of winding. Bioresorbable exterior extrusions 104 are flexible in the axially direction of removable stent 101, but rigid in the longitudinal direction. The flexibility of bioresorbable exterior extrusions 104 in the axial direction allows removable stent 101, including bioresorbable exterior extrusions 104 to be compressed into a delivery device. The center line common axis or longitudinal direction of removable stent 101 and the axial (or axially) direction are different and not parallel. Axial (or axially) directions are situated around an axis, in this case the longitudinal direction. Therefore, by including both compression of bioresorbable exterior extrusions 104 in an axial (or axially) direction along with compression of removable stent 101 has each flexible bioresorbable exterior extrusion 104 wrapped in a non-longitudinal direction around the compressed removable stent 101. The rigidity of bioresorbable exterior extrusions 104 in the longitudinal direction of removable stent 101 ensures that, once removable stent 101 is positioned in a body lumen, bioresorbable exterior extrusions 104 will resist migration of removable stent 101 within the body lumen.
Bioresorbable exterior extrusions 104 may take a variety of shapes. Bioresorbable exterior extrusions 104 of
Removable stent 301 of
Note also that bioresorbable exterior extrusions of the present invention may be used to resist migration of other types of removable stents. Other stent structures and features may be include, for example, stents having features which enhance or cooperate with the tubular and self-expandable structure or which facilitate the implantation of the structure. One example is the inclusion of radiopaque markers on the structure which are used to visualize the position of the stent through fluoroscopy during implantation. Other examples include collapsing threads or other structures to facilitate repositioning of the stent.
Note that the use of bioresorbable exterior extrusions on a removable stent would help ensure the proper position of the removable stent during its in service, or in the lumen, time. By selection of the proper bioresorbable materials, when the time to remove the removable stent has arrived, the bioresorbable exterior extrusions have been absorbed into, or broken down by the body, allowing for easy removal.
Note also that a non-bioresorbable exterior extrusion attached to the removable stent body with bioabsorbable material may also be used in the implementation of the present invention.
Delivery device 801 includes an elongated, inner tube 802, preferably having an axially extending lumen therethrough. The distal portion 809 of inner tube 801 is flexible and can be made from nylon or other suitably flexible biocompatible polymeric material. At its distal end, inner tube 801 is provided with a head 805. Head 805 serves to facilitate the insertion of delivery device 801 through a narrow opening in a body vessel. The proximal portion of inner tube 802 is preferably formed from stainless steel or other suitably rigid metal alloy. The proximal end of the distal portion of inner tube 802 is bonded to the distal end of the proximal portion of the inner tube in any conventional manner such as by using a standard adhesive.
A proximal tube 804 surrounds the proximal portion of inner tube 802 in coaxial fashion. Proximal tube 804 is preferably formed from polyurethane. The proximal end of tube 804 is connected to a valve body 803 having a side port 806. An extension tube 807 extends from side port 806 to an opening 808. This arrangement allows fluid to be injected through extension tube 807 and between proximal tube 804 and inner tube 802.
A moveable hose 901 surrounds the distal portion of inner tube 802. Hose 901 is rolled over itself to form a double-walled section. The proximal end of inner wall 1001 of a double-walled section is connected directly to inner tube 802. The proximal end of the outer wall 1002 of the double-walled section is connected to the outer surface of the distal portion of proximal tube 804. These connections can be achieved by any conventional means such as by a standard adhesive. This arrangement allows hose 901 to be rolled off removable stent 101 and placed on the distal portion of inner tube 802. By moving valve body 803 in the proximal direction, outer wall 1002 of hose 901 slides proximally over inner wall 1001. This causes inner wall 1001 to "roll back" off of removable stent 101. To facilitate movement of hose 901 off of removable stent 101, at least that portion of inner wall 1001 that contacts outer wall 1002 in the area where hose 901 is rolled over to form the double-walled section should be lubricious. The lubricious characteristic can be achieved by adding a lubricious substance to this surface of hose 901, injecting a lubricious liquid between inner wall 1001 and outer wall 1002 or forming hose 901 from a naturally slippery material such as Teflon coating.
At least the surfaces of inner wall 1001 and outer wall 1002 that face each other in the double-walled section are coated with a lubricious hydrophilic coating. In one embodiment the hydrophilic coating is 2018-M material available from Hydromer Inc. of Whitehouse, N.J. Other materials that can be used are polyethylene oxide and hyaluronic acid. When wet, the hydrophilic coating becomes lubricious and thus reduces friction between inner wall 1001 and outer wall 1002 of the double-walled section of hose 901 as outer wall 1002 moves past inner wall 1001. This facilitates the removal of the double-walled section of hose 901 from removable stent 101. Hydrophilic material may be added to hose 901 during the assembly of delivery device 801. To enable the hydrophilic material to adequately bond to hose 901, the material used to manufacture hose 901 should be matched to the hydrophilic material used. It has been found that polyurethane works well as a material for hose 901. In particular, a blend of 65D and 75D polyurethane provides sufficient flexibility to allow hose 901 to roll over itself yet still be soft enough and compatible with the hydrophilic material that it can be properly coated. In one embodiment, the blend is formed of 50% 65D polyurethane and 50% 75D polyurethane. During the assembly of delivery device 801, one side of hose 901 is coated with the hydrophilic material after the outer wall 1002 of the hose has been connected to proximal tube 804. Isopropyl alcohol is first applied to one side of hose 901 to clean the surface and remove the waxy film resulting from the plasticizers in the polyurethane. The same side of hose 901 is then coated with the hydrophilic material. The surface of hose 901 should be flushed with alcohol for about thirty seconds. Similarly, the surface of hose 901 should be flushed with the hydrophilic coating for about thirty seconds. It has been found that this technique deposits sufficient hydrophilic material on inner wall 1001 and outer wall 1002 to allow hose 901 to be rolled back with minimal friction when the hydrophilic material is wet.
After delivery device 801 has been assembled and is ready for use, the hydrophilic coating is wetted with physiological saline solution by injecting the solution through extension tube 807, past proximal tube 804 and into the space between inner wall 1001 and outer wall 1002 of the double-walled section of hose 901. Excess fluid exits from the hole 902 formed toward the distal end of the double-walled section of hose 901. In this same manner, a lubricious fluid such as polyethylene glycol can be injected into the space between inner wall 1001 and outer wall 1002 of the double-walled section to provide the lubricious characteristic of hose 901 in place of adding a lubricious hydrophilic material through hose 901 as described above.
The manner by which delivery device 801 is operated to deliver removable stent 101 to a treatment site in a body vessel or lumen including curved sections is illustrated in
A lumen is used to enable delivery device 801 to follow a guide wire (not shown) previously inserted percutaneously into the body vessel. The lumen of inner tube 802 can also be used to introduce a contrast fluid to the area around the distal end of delivery device 801 so the position of delivery device 801 can be detected (e.g., through the use fluoroscopy or X-ray techniques).
This assembly constitutes a flexible instrument intended to introduce the tubular body in contracted state into for example a blood vessel and then to expand the body when located therein. The parts of the instrument consist of an outer flexible tube 1501 and a concentric also flexible inner tube 1502. At one end of the outer tube an operational member 1503 is arranged. Another operational member 1504 is attached to the free end of inner tube 1502. In this manner the inner tube 1502 is axially displaceable in relation to the outer tube 1501. At the other end of inner tube 1502 a piston 1505 is attached which when moving runs along the inner wall of outer tube 1501.
When the instrument is to be used the tubular expansible body 1506 in contracted state is first placed inside tube 1501, the inner tube 1502 with the piston 1505 being located in the rear part 1507 of outer tube 1501. The starting position of piston 1505 is shown by dashed lines at 1508 in
During implantation the flexible tubular part of the device is inserted to the location of a blood vessel intended for implantation. Member 1504 is then moved in the direction of arrow 1509, the contracted body 1506 being pushed out through end 1510 of tube 1501, the part of the tubular body 1506 leaving tube end 1510 expanding until in its expanded position 1511 it is brought to engagement with the interior of vascular wall 1512. The tubular body 1506, 1511 is for sake of simplicity shown in
The delivery system according to
In implantation of long bodies it is conceivable that the resistance in displacing same in tube 1501 becomes too high. In this case it may be suitable to replace piston 1505 at the front end of tube 1502 with movable jaws or latches which operate in such a manner that when tube 1502 is brought forward in the direction of arrow 1509 the latches engage the inner side of body 1506, the body being brought forward. When tube 1502 is brought back in the direction of arrow 1513 the latches are released. In this manner body 1506 can be moved forwardly by a pump-like motion of tube 1502.
Many embodiments of the different members shown in
The stents of the present invention may be delivered by alternative methods or using alternative devices. For instance, the device described in Heyn et al. U.S. Pat. No. 5,201,757 may be utilized.
Although the present invention has been described with reference to preferred embodiments, those skilled in the art will recognize that changes can be made in form and detail without departing from the spirit and scope of the invention.
It will be evident from considerations of the foregoing that the devices of the present invention may be constructed using a number of methods and materials, in a wide variety of sizes and styles for the greater efficiency and convenience of a user.
The above described embodiments of the invention are merely descriptive of its principles and are not to be considered limiting. Further modifications of the invention herein disclosed will occur to those skilled in the respective arts and all such modifications are deemed to be within the scope of the invention as defined by the following claims.
|Brevet citant
|Date de dépôt
|Date de publication
|28 déc. 2010
|29 nov. 2011
|Mindframe, Inc.
|Blood flow restoration and thrombus management methods
|29 déc. 2010
|6 déc. 2011
|Mindframe, Inc.
|Multiple layer embolus removal
|29 mai 2009
|3 janv. 2012
|Mindframe, Inc.
|Blood flow restorative and embolus removal methods
|29 déc. 2010
|12 juin 2012
|Mindframe, Inc.
|Method for providing progressive therapy for thrombus management
|10 avr. 2009
|1 oct. 2013
|Covidien Lp
|Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
|26 sept. 2011
|5 nov. 2013
|Covidien Lp
|Revascularization devices
|14 juin 2012
|5 nov. 2013
|Endospan Ltd.
|Stents incorporating a plurality of strain-distribution locations
|25 oct. 2011
|19 nov. 2013
|Covidien Lp
|Expandable tip assembly for thrombus management
|15 nov. 2012
|25 mars 2014
|Covidien Lp
|Methods and apparatus for flow restoration
|28 juin 2012
|6 mai 2014
|Boston Scientific Scimed, Inc.
|Anti-migration stent with quill filaments
|23 juin 2010
|28 oct. 2014
|Endospan Ltd.
|Vascular prostheses for treating aneurysms
|10 juin 2008
|6 janv. 2015
|Covidien Lp
|Aneurysm neck bridging processes with revascularization systems methods and products thereby
|20 févr. 2009
|27 janv. 2015
|Covidien Lp
|Methods and apparatus for flow restoration
|24 juin 2013
|3 févr. 2015
|Covidien Lp
|Expandable tip assembly for thrombus management
|30 déc. 2011
|3 févr. 2015
|Covidien Lp
|Devices for restoring blood flow and clot removal during acute ischemic stroke
|30 nov. 2010
|3 févr. 2015
|Endospan Ltd.
|Multi-component stent-graft system for implantation in a blood vessel with multiple branches
|19 juin 2012
|10 févr. 2015
|Endospan Ltd.
|Endovascular system with circumferentially-overlapping stent-grafts
|8 déc. 2010
|11 aoűt 2015
|Endospan Ltd.
|Endovascular stent-graft system with fenestrated and crossing stent-grafts
|29 déc. 2008
|30 juil. 2009
|Taeoong Medical Co., Ltd
|Biodegradable double stent
|12 aoűt 2012
|7 mars 2013
|Endospan Ltd.
|Cross-reference to related applications
|Classification aux États-Unis
|623/1.2, 623/1.46
|Classification internationale
|Classification coopérative
|Classification européenne


text:
The first Gilda's Club, opened in New York in 1995, was started in memory of television comedy star Gilda Radner, whose career had been cut short by ovarian cancer.
Gilda Radner (1946-1989) rose to stardom as part of the first cast of NBC's "Saturday Night Live," which debuted in 1975.
Memorable characters she brought to life included talkative Roseanne Roseannadana and the somewhat confused Emily Litella, commentators on the show's TV news parody, Weekend Update.
The wit, timing and physical energy of her comedy style prompted comparisons to Lucille Ball, but Radner's career was cut short by ovarian cancer.
Radner, who split her time between New York and California, received help from The Wellness Community, a Santa Monica-based support group. She said she regretted being unable to find a similar organization on the East Coast.
- Win over USC puts UW's coaching upgrade (Chris Petersen over Steve Sarkisian) on full display
- Lloyd McClendon will not return as Mariners' manager
- Expect traffic delays when Obama visits Seattle Friday afternoon
- Huskies upset USC 17-12 and beat Steve Sarkisian, their former coach
- Obama visits Seattle for fundraisers; traffic not as bad as expected
Most Read Stories
After Radner's death, her actor/director husband, Gene Wilder, along with her psychotherapist, Joanna Bull, worked to create the first Gilda's Club, which opened in New York in 1995.
Gilda's Club Worldwide and The Wellness Community began working together in 2009 and last year officially merged as the Cancer Support Community.
— Jack Broom


text:
Capital Markets
Company Overview of Scottish Equity Partners LLP
Executive Profile
Brian James McBride
Venture Partner, Senior Advisor and Member of Investment Advisory Board, Scottish Equity Partners LLP
|Total Calculated Compensation
|This person is connected to 5 Board Members in 5 different organizations across 16 different industries.
See Board Relationships
Mr. Brian James McBride serves as a Venture Partner, Senior Advisor and Member of Investment Advisory Board at Scottish Equity Partners LLP. Mr. McBride served as the Managing Director and Vice President of Amazon.co.uk Limited. He served as the Chief Executive of U K Mobile Operation at Deutsche Telekom AG until January 2006. He served as the Managing Director of EE Limited since August 2003 and served as its Chief Executive Officer. He served as the Chief Executive ...
Corporate Headquarters
29 St. George StreetPhone: 44 20 7758 5900
London, -- W1S 2FA
United Kingdom
Fax: 44 20 7758 5901
Board Members Memberships
Non-Executive Director
Chairman, Chairman of Nominations Committee and Member of Remuneration Committee
Senior Independent Non-Executive Director, Chairman of Remuneration Committee and Member of Nomination Committee
EducationThere is no Education data available.
Other Affiliations
Annual CompensationThere is no Annual Compensation data available.
Stocks OptionsThere is no Stock Options data available.
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Reload the page and try again.
Greek Life:
Greek or not is truly indifferent
Greek Life:
There is no Greek life available on campus. We have stairwells in place of them.
Greek Life:
There is Greek life available at CCU but it does not play a huge role.
Greek Life:
This is a Christian college and I do not think they have a "Greek" anything, except maybe a salad in the cafeteria. I am judging this as a person without any distinct knowledge of how the college runs all of their affairs, but the Greeks were pretty "free" in my history books, and the Christians were a bit more dedicated to modesty, humility, and respect for all of God's standards for His children and followers of Christ, His Son. Again, if we use Greek words for titles within the realm of education traditions this does not encourage or condone the actions of "Greek life" that I know about.
Greek Life:
theres no greek life at school.
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Today I want to tell you about my blog friend named Shirley who is the creative brains behind Mamasakio. She makes Unusual Unique Handmade Jewelry.
About a week ago, she featured MOI in her blog post. Haha! That's why I'm writing about it. You can read that post here.
tips. Have fun visiting Mamasakio.
Fear of light coloured fabric - drawstring pouch
4 months ago


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Becoming a "manageable problem" – Obama's delusional view of ISIS
Coming soon to a city near you. As we approach the annual 9/11 anniversary, we wait for the other proverbial "shoe to drop." At least some of us. With medieval barbarism, now prominent on the world stage in the form of ISIS, and brought into American homes via internet and television, we're confronted with the real possibility of "it can happen here" again. With the | Read More »


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Tag "htc"
HTC Runnymede Product Image Surfaces
A very official looking image of the HTC Runnymede has surfaced this morning, giving us a look at both the side and the back of the device. As we've seen
HTC Runnymede Poses for Close-up Press Shot – "That's One Big White Boy"
Two weeks ago we brought you some info and a small pic of HTC's up-and-coming Runnymede (who comes up with these names?) device. The device which is set to feature
HTC Holding an Event on September 20, Possible new Android Devices?
HTC is planning to hold an event in New York next week on September 20th according to invites hitting press inboxes. The description of the event is "Come celebrate with
HTC Rhyme, Rezound Pick up DLNA Certification
A pair of unannounced HTC phones were found receiving their DLNA certification this week, one of which is new to us. Looks like it's time to start paying attention to the HTC
HTC Files Suit Against Apple, Uses Patents Obtained by Google
It's about time we saw a manufacturer fire back at Apple's extraneous patent lawsuits. I suppose it doesn't surprise me that HTC fired the first shots today. That's right, HTC
HTC Holiday Photo'd with Crazy Fast AT&T 4G LTE Speeds
Boy Genius Report has posted a number of photographs this morning which show AT&T's forthcoming HTC Holiday in the wild. What's more, the phone is seen running on the carrier's
Recently Leaked HTC Ruby (Amaze 4G) Photos Confirm Rumored Specs
A few newly leaked photos of the HTC Ruby seem to confirm some earlier rumored specs of this future juggernaut set to launch on T-Mobile in late October. The photos,
Verizon's HTC Rhyme Tipped for September 29 Release
Yet another Verizon minimum advertised price (MAP) document surfaced this week, tipping the carrier's hand a bit as it pertains to devices and prices. Whereas most of the MAP is
HTC Sensation Getting Refreshed with Beats by Dr. Dre Tech, Hardware Bump
The HTC Sensation has joined the HTC Vigor and HTC Runnymede as two Android phones expected to offer Beats by Dr. Dre technology. The Sensation? But I thought that was
HTC: Droid Incredible & Thunderbolt to Get Official Gingerbread in September
We've just gotten word from HTC via a Facebook announcement that the Droid Incredible and HTC Thunderbolt will both be receiving some Gingerbread love in September. That's literally all we
HTC Runnymede Unearthed with 4.7-inch Display [UPDATE]
Here's yet another potent Android phone to put on your radar, the HTC Runnymede. According to information gathered by Pocketnow, the device first surfaced a few weeks back when it
HTC Holiday to be Renamed HTC Raider at Launch
PocketNow have got a hold of the HTC Holiday's user agent profile, which indicates that it will be named the HTC Raider at launch. Although this will probably be the
HTC Sense 3.5 Gets an Unofficial Video Demo
The HTC Bliss, a female-focused Android handset due in late September is expected to be among the first to feature HTC's latest iteration of Sense. With one month to go
First Pair of Images of HTC Vigor Surface
A pair of images surfaced over the weekend, giving us our first decent look at Verizon's forthcoming HTC Vigor. The phone is expected to feature a number of high-end specifications


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January 2013, TruckingInfo.com - Department
By Truckinginfo Staff
IdleAir, a truck stop electrification service provider, has added a new entertainment package, ConvoyTV+Power
Tags: Idle Reduction, IdleAir, Truckstops
Comdata Corp. announced the continued expansion of its cardless fuel solution. These transactions can now process through itsSmart Solutions point-of-sale platform
Tags: Comdata, Truckstops, RFID
December 2012, TruckingInfo.com - Feature
Phillips 66 Lubricants launched two natural gas engine oils, Guardol NG and Kendall Super-D NG
Tags: Natural Gas, Natural Gas Vehicles, Liquefied Natural Gas, Truckstops
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from CITGO, will answer your questions
The expert, Rence Oliphant from Hendrickson, will answer your questions
Set of Tools Cleans Male Pins on Terminals
SecureFuel Provides Transparent Fuel Payments
McLeod Offers 'Branded' Driver App for Fleets
Paccar Announces MX-11 Diesel for North America


text:
View parents Singles in Primos Secane
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Keystone State of Pennsylvania. Find your match in Pennsylvania today! Select from thousands of personals on this free Primos Secane online dating site. Want to know how Harry met Sally? She found him in a personals ad on Match.com's Primos Secane personals Web site.
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text:
The do you really want to be
[Mister Rogers]
Just the way you are
Lyric Meaning
Vic poses an interesting question to contrast his own attributes. You see, he's proud to be all the things he listed. Are you happy being yourself?
Unless your Kendrick, the answer just might be "kind of" or even "no."
Improve the quality of La Piñata Lyrics by leaving a suggestion at the bottom of the page


text:
Marloes Coenen vs Roxanne Modafferi 2 -Strikeforce watch video >>
Roxanne Modafferi vs Marloes Coenen watch video >>
Marloes Coenen Talks Victory Over Roxanne Modafferi watch video >>
Following her submission win over Roxanne Modafferi at Strikeforce: Fedor vs. Rogers, Dutch hellcat Marloes Coenen discusses her next opponent Cris Cyborg, and her eerily focused demeanor before a fi watch video >>
Mariana Morais vs Roxanne "The Happy Warrior" Modafferi
Invicta FC 14 - Evinger vs. Kianzad watch video >>
Arlene "Angerfist" Blencowe vs Marloes "Rumina" Coenen
Bellator 141 - Guillard vs. Girtz watch video >>
Vanessa Porto vs Roxanne "The Happy Warrior" Modafferi
Invicta FC 12 - Kankaanpaa vs. Souza
Municipal Auditorium, Kansas City, Kansas, United States
April 24, 2015 watch video >>
Revisit veteran Roxanne Modafferi's win over prospect Andrea Lee at Invicta FC 10! FACEBOOK: https://www.facebook.com/InvictaFights TWITTER: https://twitter.com/InvictaFights TUMBLR: http://invictaf watch video >>
Invicta FC 10: Waterson vs. Tiburcio December 5th Houston Arena Theatre LIVE on UFC Fight Pass! watch video >>
All Angles: Roxanne Modafferi vs Tara LaRosa watch video >>


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JustPolitickin kicks off it's July networking event by hosting the Monday NetWorth Mixer with young professionals in Tallahassee, FL.
Music by: Sam Smith - Money On My Mind
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First Dog Guide Handlers Australia Conference
A first in Australia! In 2014 on the weekend of 6th and 7th September, Dog Guide Handlers Australia held its first ever conference. Held in Adelaide at the Grand Chifley, the conference was a fantastic success bringing Dog Guide Handlers, their dog guides, instructors and speakers from around Australia together, to participate in a range of workshops and engage in some great networking and peer support activity.
During the conference dinner, the inaugural Dog Guide Handlers Australia Judith Killen Golden Harness Award was presented. This award is presented to a person for their outstanding efforts in fostering, representing, promoting, enhancing and protecting the interests of Australians who are blind or vision impaired and who use a dog guide.
Dog Guide Handlers Australia would like to congratulate Rowena Dowling, the first ever recipient of the Judith Killen Golden Harness Award.
Peter Greco from the RPH Adelaide radio show "Focal Point" interviewed Rowina on her receiving the award. Rowina's interview is about 10 minutes in. To listen go to Focal Point
Episode 366 of the Blind Citizens Australia radio show, New Horizons, featured Joyce Jones, an attendee at the DGHA 2014 conference, and Rowena Dowling, speaking on recieving her Golden Harness Award.
to listen go to New Horizons episode 366
Dog Guide Handlers Australia would like to thank Guide Dogs Australia, Seeing Eye dogs Australia, the Royal Society for the Blind, Naturopaws, Blue Print Studios and BM PetSnax (supplying dog treats) for their support of the 2014 Dog Guide Handlers Australia conference.


text:
The Plastic Cup Boyz: Openers for Kevin Hart on Tour
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for The Plastic Cup Boyz was Sunday October 27, 2013 / 7:00pm.
Currently at Tommy T's Comedy Steakhouse Pleasanton
Enjoy Steamy Fun With the All-Male Dance Revue at Tommy T's
- Full Price:
- $20.00
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It's going to be a hot night at Tommy T's when Magic T brings his buddies for a night of… More
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Featured review from Grdnt
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You laugh your ass off from beginning to end, they all performed really well and although my reluctance to go drive 30 minutes, it was totally worth it. Their performance was very classy with very little cursing. Lavar Waker as opener of the openers was great and Lynn also had a great show. The free parking lot on site was nice too.
star this review starred report as inappropriate
Great time at Tommy T's The Plastic Cup Boyz were funny as heck. I had a great time with my family for this event.
star this review starred report as inappropriate
The venue tends to be a little cramp, but the lineup was awesome! Absolutely HILARIOUS! ! !


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Get That Classic Fender Sound
Electric Guitar Licks and Styles of the Greats
By Jim Weider
- Instrument:
- Format:
Electric Guitar Licks and Styles of the Greats. Instructional/Guitar/DVD. Rock. DVD. Homespun #DVDJIMFE21. Published by Homespun (HL.641619).
Item Number: HL.641619
ISBN 1932537171. rock. 5.25x7.5 inches.
Guitarist Jim Weider details the innovative and groundbreaking instrumental techniques of Roy Buchanan, James Burton, Steve Cropper, Robbie Robertson, Cornell Dupree, Freddy King, Stevie Ray Vaughan and Jimi Hendrix, and provides a close-up look at some of the famous guitars and amps that made rock 'n' roll history! An expert in Fender styles, Jim amassed a mind-boggling collection of original instruments for this session. Each is linked to a specific player and style for a complete understanding of the way they were used to achieve their trademark sounds. Early intermediate level. Includes music and tab. 1 hour, 30 minutes.
Buy Together
Get That Classic Fender Sound
Snark SN-1 Clip-on Tuner
Buy both for $41.24


text:
Thibaut Courtois
23-Year-Old Goalkeeper Chelsea Premier
|Most Popular Fantasy Soccer Stats
|Goals Allwd
|Clean Sheet
|2015 Proj.
October 2, 2015 Thibaut Courtois News
RotoWire Fantasy Analysis
Chelsea manager Jose Mourinho said Friday that the earliest Courtois could return from his knee injury is the first week of December.
Asmir Begovic will continue to start for Courtois, while the Marco Amelia has also been training with the club and could compete for Jamal Blackman for the backup job while Courtois is sidelined.
Recent RotoWire Articles Featuring Thibaut Courtois
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Published September 15, 2015
With 11 goals in his last 11 Premier League starts, Theo Walcott looks primed for regular playing time for Arsenal.
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Fantasy Premier League Rankings: Top Goalkeepers (Updated) September 8, 2015
Thibaut Courtois: Past News Updates ( ▲ View most recent update )
September 11, 2015
RotoWire Fantasy Analysis
Chelsea manager Jose Mourinho said Friday that Courtois will require surgery on his injured knee, and will be "out for quite a long time."
Courtois suffered the injury in training after returning from the international break. It's a big hit for Chelsea, though backup Asmir Begovic is a long-time starter in the Premier League and should be a solid replacement.
September 10, 2015
RotoWire Fantasy Analysis
Courtois suffered a knee injury in training Wednesday and could miss Saturday's match against Crystal Palace, the London Evening Standard reports.
The report notes that it is not believed that he suffered a torn ACL or MCL, but he could be facing an extended absence. He'll undergo scans Thursday to help determine the severity of the issue, and if he has to miss any time, Asmir Begovic would move into the starting XI.
August 31, 2015
RotoWire Fantasy Analysis
Courtois made four saves in Saturday's 2-1 defeat to Crystal Palace.
Courtois was not to blame for either goal and has now failed to keep a clean sheet in three starts this season. Much of that is down to a defence that looks unsettled at best and the Belgian may struggle to keep Everton out in the first game following the international break on Sept. 12.
August 24, 2015
RotoWire Fantasy Analysis
Courtois stopped a penalty kick en route to two saves during Sunday's 3-2 win at West Brom.
Courtois and Chelsea's defense has leaked seven goals through their first three league matches, but the Belgian goalkeeper came up big with a penalty save 14 minutes into Sunday's match. After serving a one-match ban for a red card picked up in the Blues' opening match, Courtois figures to be Chelsea's regular starter moving forward and will try to shore up his defensive unit ahead of this weekend's London derby against Crystal Palace.
August 21, 2015
RotoWire Fantasy Analysis
Courtois will start Sunday against West Brom after serving a one-match red-card ban.
Asmir Begovic will move back to the bench in favor of Courtois, who will face off against a West Brom side that has yet to score this season through two matches.
August 12, 2015
RotoWire Fantasy Analysis
The FA has rejected an appeal of Courtois' one-game suspension for receiving a red card in Saturday's draw with Swansea, reports the Daily Mail.
Chelsea appealed the suspension to allow the keeper to take part in the side's next match against Manchester City. Courtois will miss the encounter after the FA upheld the referee's decision.
August 8, 2015
RotoWire Fantasy Analysis
Courtois made three saves and allowed one goal versus Swansea City on Saturday, but he was sent off in the 52nd minute following a foul on Bafetemi Gomis as he broke into the box.
It was an eventful day in all for the Belgian, who injured himself during warmups and had to undergo a last-minute fitness test just to start the match. He played quite well before the sending off and even made a top-drawer save before Swansea tapped home their first goal on the rebound. Courtois will now miss next week's match at Manchester City, where Asmir Begovic is expected to deputize.


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Campground EventsListing Calendar
Fall Family Festival
Join us for our 4th annual Fall Family Festival, with hay wagon rides, pumpkin picking, and all kinds of FUN! Best of all, it's a BOGO weekend - buy one night, get one free! See our Hot Deals page to get the discount online.
4th Annual Fall Festival at KOA
An annual weekend of family-friendly fall fun, right at the KOA Campground! Includes fall crafts, pumpkin picking, hay wagon rides, roasty toasty bonfire, and more.


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Sourpuss Pink Eyeball Earrings
(approx. $7.52 or €6.81)
- In Stock
- Usually Ships in 1-2 Days
- UK & Worldwide Delivery
- Product Type: Earring
- Product Code: 61625
Looking for a pair of earrings to add an alternative twist to your wardrobe? Look no further than these striking studs from Sourpuss. Set on vibrant pink with blood shot eyeballs, these fun earrings will make an eye-catching addition to any outift.