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Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
ABSTRACT Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non-small-cell lung cancers, representing 2 to 7% of such tumors. We explored the therapeutic efficacy of inhibiting ALK in such tumors in an early-phase clinical trial of crizotinib (PF-02341066), an orally available small-molecule inhibitor of the ALK tyrosine kinase.
After screening tumor samples from approximately 1500 patients with non-small-cell lung cancer for the presence of ALK rearrangements, we identified 82 patients with advanced ALK-positive disease who were eligible for the clinical trial. Most of the patients had received previous treatment. These patients were enrolled in an expanded cohort study instituted after phase 1 dose escalation had established a recommended crizotinib dose of 250 mg twice daily in 28-day cycles. Patients were assessed for adverse events and response to therapy.
Patients with ALK rearrangements tended to be younger than those without the rearrangements, and most of the patients had little or no exposure to tobacco and had adenocarcinomas. At a mean treatment duration of 6.4 months, the overall response rate was 57% (47 of 82 patients, with 46 confirmed partial responses and 1 confirmed complete response); 27 patients (33%) had stable disease. A total of 63 of 82 patients (77%) were continuing to receive crizotinib at the time of data cutoff, and the estimated probability of 6-month progression-free survival was 72%, with no median for the study reached. The drug resulted in grade 1 or 2 (mild) gastrointestinal side effects.
The inhibition of ALK in lung tumors with the ALK rearrangement resulted in tumor shrinkage or stable disease in most patients. (Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.).
Full-textDOI: · Available from: Jeffrey W Clark, Sep 29, 2015
- SourceAvailable from: Francisco G. La Rosa
- "With ALK gene rearrangement, the signals move apart from each other to give the split signal, which is considered positive. We scored a total of 50 to 80 tumor cells per specimens and presence of at least 15% of cells showing separated 3'ALK and 5'ALK signals or single 3'ALK signals classified the specimen as positive for ALK rearrangement [Kwak et al. 2010]. "
Article: Anaplastic lymphoma kinase (ALK) gene alteration in signet ring cell carcinoma of the gastrointestinal tract[Show abstract] [Hide abstract]
ABSTRACT: ALK-EML4 translocation is an established driver aberration in non-small cell lung cancer (NSCLC), with reported predilection for cases with signet ring histology. We assessed the presence of anaplastic lymphoma kinase (ALK) gene rearrangements in signet ring cancers arising in the stomach and colon. Histologically confirmed cases of signet ring adenocarcinoma of the stomach or the colon were identified. The presence of the classic ALK and EML4 fusion gene was initially determined by fluorescence in-situ hybridization (FISH) technique. Immunohistochemistry (IHC) was performed using two previously validated antibodies, ALK1 clone (1:100; DAKO) and 5A4 (Novocastra, Leica Biosystems) along with positive controls of ALK-translocated lung cancer. We employed 42 cases of signet ring carcinoma diagnosed between 2001 and 2011; 25 gastric and 17 colon cancer. Median age 63.3 years; male/female 17/25; race, black 47.5%, white 47.5%, others, 5%; stage I, 21.4%; stage II, 31%; stage III, 26.2%; stage IV, 21.4%. One of 42 cases (2.3%) was positive for ALK translocation by FISH using the standard criteria of at least 15% positive cells for the break-apart signal (50-70 cells enumerated per case). Using a less restrictive cut-off of 10% positive cells, 7 cases (16%) were considered possibly positive. None of the 'possibly positive' cases was found to harbor ALK translocation by another molecular testing approach (IHC). IHC with two previously validated monoclonal antibodies showed 0 of 42 (0%) cases positive. ALK gene rearrangement is very rare in gastrointestinal cancers and enrichment strategy focusing on signet ring cell histology did not significantly improve the detection rate.03/2015; 7(2):56-62. DOI:10.1177/1758834014567117
- "2.3. Gastrointestinal toxicity Crizotinib-associated gastrointestinal toxicities include nausea (47–57%), vomiting (39–47%), diarrhea (41–60%), and constipation (28–42%) [4] [11] [12] [14] "
Article: Management of crizotinib therapy for ALK-rearranged non-small cell lung carcinoma: An expert consensus[Show abstract] [Hide abstract]
ABSTRACT: Within 4 years of the discovery of anaplastic lymphoma kinase (ALK) rearrangements in non-small cell lung cancer (NSCLC), the ALK inhibitor crizotinib gained US and European approval for the treatment of advanced ALK-positive NSCLC. This was due to the striking response data observed with crizotinib in phase I and II trials in patients with ALK-positive NSCLC, as well as the favorable tolerability and safety profile observed. Recently published phase III data established crizotinib as the new standard of care in the second-line setting for this NSCLC molecular subset. A consequence of such rapid approval, however, is the limited clinical experience and relative paucity of information concerning optimal therapy management. In this review, we discuss the development of crizotinib and the clinical relevance of its safety profile, examining crizotinib-associated adverse events in detail and making specific management recommendations. Crizotinib-associated adverse events were mostly mild to moderate in severity in clinical studies, and appropriate monitoring and supportive therapies are considered effective in avoiding the need for dose interruption or reduction in most cases. Therapy management of patients following disease progression on crizotinib is also discussed. Based on available clinical data, it is evident that patients may have prolonged benefit from crizotinib after Response Evaluation Criteria in Solid Tumors-defined disease progression, and crizotinib should be continued for as long as the patient derives benefit.Lung Cancer 12/2014; 87(2). DOI:10.1016/j.lungcan.2014.12.010 · 3.96 Impact Factor
- "NSCLC can be molecularly characterized by the presence of mutations in oncogenes and tumor suppressor genes, which frequently determine the therapeutic approach to these tumors. Targeted therapies for tumors with EGFR mutations [4e6] and Alk-translocations [7] are available and new targets such as RET and ROS1 fusions, BRAF, and ERBB2, are rapidly emerging. Nonetheless, a large percentage of lung cancers are not driven by single oncogene mutations and improvements in better selection of standard chemotherapy drugs or the development of novel targeted approaches to overcome chemo-resistance are essential for patients with these tumors. "
Article: Molecular characteristics of non-small cell lung cancer with reduced CHFR expression in The Cancer Genome Atlas (TCGA) project[Show abstract] [Hide abstract]
ABSTRACT: CHFR expression has previously been established as a powerful predictor for response to taxane based first-line chemotherapy in non-small cell lung cancer. It is currently unknown however, if reduced CHFR expression correlates with certain molecular subtypes of lung cancer. In order to determine which patients may benefit from CHFR biomarker testing we conducted the present study to characterize clinical and molecular characteristics of patients with reduced vs. high CHFR expression. We utilized the extensive molecular and clinical data of the most recent adeno- and squamous cell carcinoma datasets from The Cancer Genome Atlas (TCGA) project. CHFR expression, analyzed by RNA-seq, was classified as high vs. low based on the median CHFR expression level and correlated with the presence or absence of lung cancer specific mutations (EGFR, KRAS, ALK, MET, ERBB2, TP53, STK11, ROS1, RET, NF1, Pik3CA for adenocarcinomas and FGFR1, FGFR2, FGFR3, TP53, STK11, EGFR for squamous cell carcinomas). Reduced CHFR expression was associated with EGFR exon19/21 mutations in adenocarcinoma OR 0.23 (95%CI: 0.06-0.88) and male gender in squamous cell carcinoma (OR 0.46 (95%CI 0.23-0.92), p = 0.02). Published by Elsevier Ltd.Respiratory Medicine 11/2014; 109(1). DOI:10.1016/j.rmed.2014.11.004 · 3.09 Impact Factor


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editor's review
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text: Table of Contents – April 2008 – Military History HistoryNet Staff 2/13/2008 Subscribe to Military History magazine today! FEATURES Cover Story Churchill Takes Charge [online] By Williamson Murray In the summer of 1940, it took just eight weeks for Britain's new prime minister to set the Allies on the road to victory Sniper: America's Army of One By Geoffrey Norman Since the Revolution, U.S. snipers have made a tactical difference The Dreyfus Nightmare By Douglas Porch Alfred Dreyfus' 1890s military trials for treason fractured France Crushed on the Horns of Hattin By James Lacey In 1187 Saladin's Muslim armies drove the Crusaders from the East Portfolio: The Cat in the Helmet During World War II, humorist Dr. Seuss skewered isolationists, Nazis and appeasers Can We Trust the Ancient Texts? By Richard A. Gabriel Sources for ancient military history amount to a handful of texts DEPARTMENTS Letters Letter From the Editor News Interview: Paul Cartledge: East Vs. West At Thermopylae WHAT WE LEARNED… from Cynoscephalae VALOR Showdown at Chau Doc HAND TOOL Mail POWER TOOL T-34/76 tank REVIEWS HALLOWED GROUND Bastogne, Belgium WAR GAMES WEAPONS WE'RE GLAD THEY NEVER BUILT Capo Ferro's Comic Commandos ONLINE EXTRAS Discussion: "Can combining accounts from opposing sides of an ancient battle (e.g., Egyptian and Hittite records from the Battle of Kadesh) provide a more accurate picture?" Link World War II: Winston Churchill's Vision of Victory The British prime minister's deft handling of the ship of state ensured that the Allies endured the darkest moments of World War II and were ready for victory when it finally came. Third Crusade: Siege of Acre A magnet for centuries to competing armies, Acre at last would be leveled-but not before it would house both warring Christians and Muslims. Battle of Kadesh Emulating Thutmose III, young Ramses II led his Egyptian host deep into Syria — blissfully ignorant that he was doing exactly what Hittite King Muwutallis wanted him to do. Leave a Reply Cancel Reply Your email address will not be published. Name* Email* Website Comment


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Internet Software and Services
Company Overview of Shazam Entertainment Limited
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Rich Riley
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Mr. Rich Riley has been the Chief Executive Officer of Shazam Entertainment Limited since April 2013 and also served as its Managing Director. Mr. Riley served as the Chief Executive Officer of SHAZAM, Inc. Mr. Riley served as an Executive Vice President of Americas of Yahoo! Inc. since April 2012. He oversaw all go-to-market activities and operations for consumers, advertisers and partners in the region. He served as Vice President and General Manager, Yahoo! Small ...
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On a cold, blowy, darkest of nights, I was awakened with a start by a presence in my room, not that of a child or a pet or even a Japanese beetle but of something the likes of which I'd never seen, sort of an eerie being that seemed to loom.
He arrived not in Victorian bedclothes but in a work uniform with his name on his breast, his face creased with hard work and palms rough but strong, many muscles rippling in his chest.
Guy Grubbs' cows are thirsty. It's nearly milking time, so this 55-year-old farmer lets his eager Holsteins through two gates to the water troughs.
"I've milked cows all my life, and we've had some tough times, but I've never seen one this prolonged," said Grubbs, a third-generation dairyman.
Some will remember Ashley Ford for her abilities on the basketball court and her positive attitude, but her mother said she will miss her for something much more special – a really sweet smile.
"You never saw her without a big smile on her face," Kim Hardin said Thursday. "Her smile would just light up the whole room."
Although the East team lost, 40-20, in Saturday's Greater Louisville Coaches Association East vs. West All-Star Football Game at Southern, Shelby County High School was well represented.
Kicker Matt Nakatani was 2-for-2 on extra points and forced a fumble on a kickoff, but the West recovered it. Defensive lineman Justin Hampton had three tackles and one quarterback pressure, and offensive lineman Matt Axline did not allow a sack.
The SHCS football team led the way with 10 players earning spots on the All-Class 6A, District 4 Team. Male was second, with nine players, Fern Creek had seven, and Southern had two.
The Rockets honored on offense were quarterback Branden Cresap, Jr.; wide receivers – Ben Axline, Jr., and Tavis Elzy, Jr.; offensive tackle Matt Axline, Sr.; and guard R.J. Beitz, Sr.
To view this section in full screen, please click on the arrow at the top right of the Print2Flash viewer and select Open In New Window.
We now may have a clue what caused Kentucky Gov. Steve Beshear to issue his surprising and disappointing statement Thursday about Shelby County's recruitment of the Harley-Davidson plant.
The contract that workers at Harley's plant in York, Pa., received Friday morning included a commitment that if the union ratified the agreement that the company would discontinue its discussions with officials in Kentucky.
Democrat Eddie Kingsolver has filed to run once again for magistrate in District 5.
Kingsolver sought the same position in May 2006 and lost the Democratic primary to Betty Curtsinger by a scant 15 votes. Curtsinger currently serves the district.
As the acting State Auditor, Crit Luallen said she knows a thing or two about "values."
"That's a word that gets thrown around casually in politics too often," she said. "But if there's one key lesson that I've learned in my long career, it's that having strong personal values and holding ourselves to the highest ethical standards that determines success in the public arena."
Republican David Glauber of Bullitt County filed Friday to run for the 20th district state senate seat being vacated in 2010 by incumbent Gary Tapp.
Tapp announced earlier this year that he would not seek re-election and endorsed Shelby County farmer Paul Hornback to succeed him in a district that encompasses Shelby, Bullitt and Spencer Counties.
Glauber, a member of the Appraisal Institute, is a Carroll County native who moved to Bullitt County in 1993. This election is his first time running for office.
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The Sentinel-News is your source for local news, sports, events and information in Shelby County and Shelbyville, KY, and the surrounding area.


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- September 28-30 (preview Sep. 13)
nD Festival
nD Festival is a fundraiser that directly supports the Belcourt's education and engagement programs, with special events and parties celebrating indie film, fashion and music.
This year's nD Festival includes a Preview on Sept 13, followed by three days of events, Sept 28-30. (See below for a full description of all nD events.)
With your purchase of nD tickets, you help make it possible for the Belcourt to provide post-film discussions and Q&As, film symposiums, and community collaborations with organizations like the Martha O'Bryan Center and the Oasis Center.
nD Festival chairs are Nan Flynn and Monica Mackie. Honorary chairs are Carrie and Matt Eddmenson of Imogene + Willie.
nD Festival Patrons Passes:
nD Patrons Pass includes FREE admission to all nD events, including the Patrons Party.
•$225/includes a Belcourt Cast & Crew membership with year round benefits •$175/Belcourt members
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1999 Subaru WRX Roof Cargo Baskets
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800 Words: Preview - Tuesday, 13th October
George will be coming face-to-face with his childhood nemesis... don't miss an all-new 800 Words on Tuesday after The X Factor.
31 minutes ago
George will be coming face-to-face with his childhood nemesis... don't miss an all-new 800 Words on Tuesday after The X Factor.
31 minutes ago
What are Red and Liz up to? We've got the first episode of Season 3 available now - well the first few minutes of it! Get a taster of the upcoming season now. Returns to Seven, Wed 7 Oct, 8.30PM
1 hour, 32 minutes ago
FBI Agent Elizabeth "Liz" Keen (Megan Boone) is now a fugitive and on the run with criminal mastermind Raymond "Red" Reddington (James Spader). As they struggle to stay one step ahead of …
October 7, 11:25 am
Officers are pushed to their limits by a Chinese man's outrageous behaviour.
October 7, 10:29 am
Tune in to an all new episode of The Chase Australia, 5pm weekdays.
October 7, 12:00 am
Tonight, two acts will have to sing for their lives! Will one of your favourites be going home?
October 6, 2:55 pm
From driving offences to missing persons to drugs, see how the officers respond to the dangerous, tragic and often funny situations that are part of their everyday lives through Summer, when the …
October 6, 1:18 pm
Tune in to an all new episode of The Chase Australia today at 5pm.
October 6, 12:47 pm
Narrated by Layne Beachley, Beach Cops follows the police men and women who operate along Sydney's Northern Beaches.
October 6, 11:41 am
The Shark and the Supernerd are still undefeated... can they survive another week or will our teams be able to take them down? The Chase airs weekdays 5pm on Seven.
October 3, 12:00 am
We get up close and personal with the stars of Bangla Rd - the Ladyboys. We meet Sharky, the infamous Gold Coast loan shark making a name for himself in Pattaya.
October 2, 4:55 pm


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As we mentioned, the 2012 quarterback crop isn't lush, a fact that opens the door for dark horses to rise, and Nassib might be the preeminent dark horse coming out. "He's gonna end up being one of those guys," said one NFC exec. "I like his arm, his release, his mechanics, and he's really strong — he can throw the (expletive) out of the ball. He's ready, too." Nassib could conceivably go in the second round, particularly considering his experience under Marrone, who was Sean Payton's offensive coordinator with the New Orleans Saints in 2006.
- Nassib, Marrone see their NFL stocks rise
- Is the Pinstripe Bowl going out of style?
- The 2009 recruiting class saved Syracuse football
- Orange ring bell at NYSE
- Snow storm detours three Syracuse basketball players
- Take Syracuse over West Virginia in Pinstripe betting
- Pinstripe Bowl will be high scoring affair
- Geno Smith ready for final college game
- How will Syracuse adjust to loss of Ameen-Moore?
- Syracuse has penultimate practice before bowl game
- Pinstripe Bowl media day interviews (video)
- Chris McCullough on top 10 players on the rise
» Got a link or a website you'd like to see here? Let us know
For more Syracuse coverage, Like our Facebook page and follow us @TheJuiceOnline.
- Syracuse football: Defense & Special Teams report card through four games - October 7, 2015
- Syracuse football: Offense report card through four games - October 5, 2015
- Mixed Juice: What is the impact of Syracuse losing Moustapha Diagne? - August 24, 2015
- What is the significance of Syracuse football restoring 44? - May 22, 2015
- Early 2015-16 Odds Update on the Orange - May 22, 2015
- 2015 NCAA Tournament predictions: Syracuse lacrosse will win it all - May 7, 2015
- Michael Carter-Williams gets hit twice as Bucks eliminated - May 1, 2015
- Mixed Juice: On Syracuse guard Malachi Richardson's playing time - April 28, 2015
- Tim Welsh: Syracuse head basketball coach Jim Boeheim a 'fighter' - March 23, 2015
- Duke's Jahlil Okafor, Syracuse's Rakeem Christmas headline TJO's All-ACC Awards - March 9, 2015


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Archive: February, 2010
Flyers show heart; Leighton (not Turco) in nets
Sam Carchidi, Inquirer Staff WriterNEWARK, N.J _ Goalie Michael Leighton called it a "character" win. Defenseman Chris Pronger said the Flyers "showed a lot of moxie." No argument here. For the second time in as many games, the Flyers overcame a 2-0 deficit and stunned the Atlantic Division-leading New Jersey... Read more
For Flyers, a rare comeback; club wants All-Star Game, draft
Sam Carchidi, Inquirer Staff WriterFor one of the few times this season, the Flyers didn't disappear after falling behind. Trailing 2-0, the Flyers scored two goals late in the second period, then won it on Mike Richards' power-play goal with 7:58 left as they outlasted the visiting New Jersey Devils, 3-2, at the Wachovia... Read more
Problems in Flyersville
Sam Carchidi, Inquirer Staff WriterThe news coming from Flyersville is not good: Goalie Ray Emery is hurt again. Oh, and the Flyers, trying to make up for their glaring lack of offensive depth, acquired a player who had managed just four goals and was minus-10 this season. First, Emery. Earlier this season, Emery missed about six... Read more
Flyers fire blanks (again)
Sam Carchidi, Inquirer Staff WriterST. PAUL, Minn. _ Flyers goalie Michael Leighton, subbing for the injured Ray Emery, deserves better. Yes, he gift-wrapped two goals Saturday that, as it turned out, gave Minnesota a 2-1 win. But Leighton is the guy who seemingly rescued the Flyers season as he went 8-0-1 with one no-decision in his... Read more
Kovy trade: Devils had depth to deal, Flyers didn't
Sam Carchidi, Inquirer Staff WriterAn NHL source tells us the Flyers were never a serious player in the sweepstakes for Atlanta superstar winger Ilya Kovalchuk, a potential unrestricted free agent after the season who was dealt to New Jersey Wednesday night. Kovalchuk, who has 31 goals, turned down two mega offers from the Thrashers... Read more
For Flyers, an offensive loss
Sam Carchidi, Inquirer Staff WriterEDMONTON, Alberta _ The Flyers outplayed the lowly Edmonton Oilers, but suffered a crushing 1-0 defeat on a goal by Ryan Potulny with 16.1 seconds left Wednesday night. As if losing to the team with the NHL's worst record wasn't bad enough, the winning goal was scored by a former Flyer... Read more
Leighton gets call; Emery fine, GM says
Sam Carchidi, Inquirer Staff WriterGoalie Michael Leighton (remember him?) will get the start for the Flyers Wednesday night in Edmonton. Coach Peter Laviolette wrestled with the decision for most of the day before finally deciding to give Leighton his first start since Jan. 14. Ray Emery, coming off a 3-0 win in Calgary Monday, had... Read more
Emery starting vs. Calgary
Sam Carchidi, Inquirer Staff WriterRay Emery will make his eighth straight start in goal, and newcomer Lukas Krajicek will be paired with defenseman Oskars Bartulis for Monday's game in Calgary, coach Peter Laviolette said after the morning skate. Overall, Emery has a 2.73 goals-against average, but it was 2.04 _ with a .929 save percentage... Read more
Richards reaches milestone in shutout; Krajicek impresses
Sam Carchidi, Inquirer Staff WriterCALGARY, Alberta _ Mike Richards scored two goals _ including the 100th of his career _ and Ray Emery notched his third shutout of the season as the Flyers blanked host Calgary, 3-0, on Monday night. Emery, who made his eighth staright start, was forced to make only 18 saves because of a stellar backchecking... Read more
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Publisher's Description+
Mozilla Thunderbird makes e-mailing safer, faster, and easier with such features as intelligent spam filters, a built-in RSS reader, and quick search. Thunderbird was designed to prevent viruses and to stop junk mail. Thunderbird includes tabbed e-mail, new search tools and indexing, smart folders, support for Firefox's Personas, a simplified setup wizard, and robust junk protections that include phishing and spam filters. Thunderbird has a junk mail tools have been updated to stay ahead of spam and features Phishing protection.
What's new in this version:
Version 12.0.1 includes fixes for issues relating to new mail notifications and filtering on POP3 based accounts, occasional startup crash seen in TB 12.0, and an issue with corrupted message bodies when using move mail.


text:
Dave East Interview
Dave East talks Harlem, his 'Hate Me Now' mixtape and the near-death experience that changed his life.
Dave East talks Harlem, his 'Hate Me Now' mixtape and the near-death experience that changed his life.
From Bahamadia's 'Kollage' to Bubba Sparxxx's 'Deliverance' and more, here are 20 Underrated Rap Albums You Need in Your Collection.
The new singer opens up about his 'TRAPSOUL' album, inspiration from Kanye West and sleeping in his car.
In honor of Miss Jackson's (if you're nasty) return, The Boombox has compiled a list of the 20 Janet Jackson Songs That Made You a Fan.
Nelly performs two throwback hits, "Hot in Herre" and "Ride Wit Me," for Off the Record.
Today, we celebrate the birthday of one of '90s R&B's finest, Toni Braxton, who couldn't escape being name-dropped on rap songs -- just listen to Method Man and Redman's "Part II." It was perhaps because she was just that good. The singer turns 48 years old today (Oct. 7).
Nicki Minaj gets extremely candid in an in-depth interview with The New York Times Magazine. The Queen Barbz addresses everything from the Drake and Meek Mill feud to dealing with body image issues and being a strong businesswoman.
Dave East stopped by The Boombox office to discuss his stomping grounds, his 'Hate Me Now' mixtape, resurrecting the Notorious B.I.G. and the near-death experience that changed his life.
How many of you were properly equipped for the rain that Hurricane Joaquin poured down on us? If you were lacking in the waterproof footwear department then this latest Puma drop could save you from having to suffer "Soggy Sock Syndrome" ever again.
Rick Ross is in Meek Mill's corner. The Maybach Music Group leader is voicing his opinion on the beef between the Philadelphia rapper and Drake that erupted over the summer.
Kevin Durant's eighth Nike release has been way more of a hit than a miss and to really drive the point home, the brand gives the sneaker one of the most foolproof colorways of all time -- black and gum. But this isn't your typical color blocking as it's backed by an innovative upper as well.
We're going to party like it's 1989 since Will Smith announced that he's going on tour with DJ Jazzy Jeff next year.
Our thoughts and prayers are with former Three 6 Mafia member Koopsta Knicca, who suffered a brain aneurysm, according to the group's founding member, DJ Paul.
Missy Elliott is having a misdemeanor of her own. The Grammy Award-winning rapper was hit with a $75,000 lawsuit this week for allegedly missing a Brazilian TV appearance and two concerts.
If you missed out on the monochromatic flood of Pharrell Williams' Supercolor collaboration with Adidas, there is finally a consolation prize of sorts for you. The Adidas Originals Superstar Tonal Perf Pack is a one-color take on the beloved shell toe with an awesome twist.


text: Physics "The Epic Rise and Dramatic Fall of the Atomic Era" (Encore presentation.) By Rich Fisher • Jun 20, 2014 (Please note: This show first aired earlier this year.) On this edition of ST, we speak with Craig Nelson --- who's written for Vanity Fair, Salon, Popular Science, and other periodicals, and who's the bestselling author of "Rocket Men" as well as a biography of Thomas Paine --- about his newest book, which is an engrossing cultural history of the Atomic Age. "The Age of Radiance: The Epic Rise and Dramatic Fall of the Atomic Era" is, as was noted by Kirkus Reviews, "no impersonal 'march of science' story. Nobel Prize-Winning Physicist Frank Wilczek to Appear in TU's Presidential Lecture Series By Rich Fisher • Mar 24, 2014 Each year, the University of Tulsa's Presidential Lecture Series hosts distinguished speakers on a range of fascinating topics; all lectures are free to the public. The Presidential Lecture Series is sponsored by The Darcy O'Brien Endowed Chair and supported by the University's Office of the Provost. TU's next Presidential Lecturer will be Frank Wilczek, the well-known theoretical physicist and mathematician who's also a professor at MIT. Wilczek's talk begins at 7:30pm on Thursday the 27th; it happens in the Reynolds Center, at 3208 East 8th Street, and reservations are not required.


text:
"We only move into the 21st century on the foundation of things that have been established long, long ago."
"Untitled (#96)" (1981)
"I haven't titled anything since the Film Stills. Beside the fact that I never felt very much of a wordsmith, I didn't want people to have a preconceived notion of what they're supposed to imagine."
-Cindy Sherman


text:
Hello to all! The forum is great!
I have a one question: I am tall 170 cm. (66,9 inches) with:
Inseam - 73 cm (28,7")
Trunk - 62 cm (24,4")
Forearm - 33 cm (12,9")
Arm -60 cm (23,6")
Thigh - 55 cm (21,6")
Lower Leg 56 cm (22")
Sternal Notch - 140 cm (55,1")
Which size of hardtail frame is for me? I could't find calculator for 29er frames in Internet!
Please for your help!
Sorry, If my questions is discussed! You can post similar threads!
Every day i ride road bike with flatbar in my city! My bike is 54 cm (21") size!
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The teacher's role in promoting collaborative dialogue in the classroom
Article first published online: 24 DEC 2010
2009 The British Psychological Society
British Journal of Educational Psychology
Volume 79, Issue 1, pages 1–28, March 2009
Additional Information
How to Cite
Webb, N. M. (2009), The teacher's role in promoting collaborative dialogue in the classroom. British Journal of Educational Psychology, 79: 1–28. doi: 10.1348/000709908X380772
Publication History
- Issue published online: 24 DEC 2010
- Article first published online: 24 DEC 2010
- Received 9 October 2008; revised version received 9 October 2008
- Abstract
- Article
- References
- Cited By
Background Research on student-led small-group learning in schools going back nearly four decades has documented many types of student participation that promote learning. Less is known about how the teacher can foster effective groupwork behaviours.
Aims This paper reviews research that explores the role of the teacher in promoting learning in small groups. The focus is on how students can learn from their peers during small-group work, how teachers can prepare students for collaborative group work, and the role of teacher discourse and classroom norms in small-group dialogue.
Method Studies selected for review focused on student-led small-group contexts for learning in which students were expected to collaborate, reported data from systematic observations of group work, and linked observational data to teacher practices and student learning outcomes.
Results and conclusions This review uncovered multiple dimensions of the teacher's role in fostering beneficial group dialogue, including preparing students for collaborative work, forming groups, structuring the group-work task, and influencing student interaction through teachers' discourse with small groups and with the class. Common threads through the research are the importance of students explaining their thinking, and teacher strategies and practices that may promote student elaboration of ideas.


text:
about Todd FlowerdayA Roman Catholic lay person, married (since 1996), with one adopted child (since 2001). I serve a parish in music ministry.
about John Donaghy
John is a lay missionary since 2007 with a parish in western Honduras. Before that he served in campus ministry and social justice ministry in Iowa. His ministry blog is http://hermanojuancito.blogspot.com
He also blogs reflections on the lectionary and saints/heroes/events of the date at http://walktheway.wordpress.com
He'll be a long-term contributor here analyzing the Latin American bishops' document from their 2007 Aparecida Conference.
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What is Tridentine Catholicism?
(This is Neil) The purpose of this post is to attract your attention to the learned Jesuit historian Robert Bireley's recent Presidential Address to the Catholic Historical Association, published in the April, 2009, Catholic Historical Review. What, then, is "Tridentine … Continue reading
Posted in Church History, Neil 10 Comments
Dr Tiller and Blame
The Catholic blogosphere, awash in posts on Dr Tiller, tries to make some sense of the senseless. Most bloggers are covering the obvious aspects quite well, and I have no wish to walk the well-trod path, except for one statement: … Continue reading
Posted in Commentary, Politics 22 Comments


text: cars By January 21, 2013 11:07 AM Share on Facebook Share on Twitter Category: Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of 92.9 KNIN Oh-So Resourceful Kid Uses Everyday Objects to Make Killer Drum Set Actor Shia LaBeouf Arrested in Downtown Austin for Public Intoxication Throwing Pumpkins Off The World's Littlest Skyscraper With James Huling of 'Big Brother 17′ Watch People Ages 0-100 Bust Out Their Best Dance Moves Recommended For You Best of the Web


text:
by roachnelson [OP] » Mar 08 2012, 7:39am
by roachnelson [OP] » Aug 26 2012, 9:59pm
by SSSilverado23 » Sep 06 2012, 11:36pm
by roachnelson [OP] » Sep 07 2012, 5:33am
by SSSilverado23 » Sep 07 2012, 5:39am
roachnelson wrote:My truck does not have any after cat o2 sensors, so it does not affect anything on the computer side. was very quick and simple and we have no emmisions checks here.
by roachnelson [OP] » Sep 08 2012, 12:20am
by SSSilverado23 » Sep 08 2012, 12:29am
roachnelson wrote:2004
by roachnelson [OP] » Sep 08 2012, 3:52am
by roachnelson [OP] » Jan 23 2013, 2:27pm
by roachnelson [OP] » Feb 08 2013, 3:21am
back mine tips installed black tricks engine done anyone used side lights check rear think work still great
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Blessings all around Saturday at Indian River Humane Society
VERO BEACH — Four-legged creatures of all shapes, colors and sizes joined their human counterparts at The Humane Society of Vero Beach and Indian River County on Saturday morning for its annual Blessing of the Animals.
The nondenominational service was conducted by the Rev. Deacon Lew Gwyn of Trinity Episcopal Church and the Rev. Mindy Serafin, chaplain at Indian River Medical Center, and was followed by some personal attention with an individual blessing for each pet.
"It's simply a celebration of Gods gifts to us," said Gwyn smiling, adding, "It's one of my favorite church services of the year."
The event coincided with "Be Kind to Animals Week" in an effort to emphasize the responsibility mankind has to properly care for the creatures that are unable to care for themselves.
"Today we commemorate the very special role animals play in our lives," said Chalmers Morse, the society's executive director. "We are celebrating the bond between pets and their human families."
For more information on The Humane Society of Vero Beach and Indian River County, visit www.hsvb.org.
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TripAdvisor Reviews Slough Creek Campground Yellowstone National Park
Travel Blogs from Yellowstone National Park
White Water Rafting
Today is the day the kids have been excited about, white water rafting. We set out around 9:30am to Wild West Rafting in Gardiner, Montana. It is a 2 hour drive from our campsite. This is right outside the Yellowstone north entrance. Prior to today Liana had asked me if I would be going down the river with them. I told her probably not, I wasn't …
Our way home
Day 4. Time to drive home. We decided we would take the chance with the road construction and finish the loop around the park. The construction delay was minimal so we were glad we did. Along the drive west we stopped to see two new falls for us - Wraith and Undine.
In Mammoth we stopped at the newly reopened visitor center. I knew it had been redone, ...
Yellowstone Day 2
... we pulled up.
Everywhere we drove there was evidence of the horrendous 1988 fire. Dead trees still standing, fallen trees and amazing regrowth. The lodge pole pines in Yellowstone have two sorts of cones, one of which only opens and germinates with the heat of a forest fire.
The loop road in Yellowstone is figure 8 shaped, so half today and half tomorrow. Set off for the Upper Geyser Basin, stopping at Kepler Cascades en ...
Yellowstone National Park
... to complete the preservation of the wilderness. Then Yellowstone, America's first National Park, established in 1872. One of the biggest parks in USA and maybe the most famous. So many Discovery Channel shows, we know what to expect. Started by driving north towards the Grant Village Visitor Centre. Chatted en route to a cyclist from UK who is cycling across USA with pals, taking 10 weeks. Looked into the Lewis Canyon. Further on, lunch ...
Yellowstone Lake
Ah, Lake Yellowstone, a place we never get tired of viewing. We know we have arrived here when we can look out on that vast lake, the largest Alpine lake in North America. We always enjoy going to the store at Fishing Bridge. Both the Visitor ...
Other places to stay in Yellowstone National Park
Roosevelt Lodge CabinsPO Box 165, Yellowstone National Park | 2 star campgroundfrom $210
Grant Village CampgroundGrant Village, Yellowstone National Park | Campgroundfrom $75
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text: Microsoft has shown interest in Facebook too, but not in the creepy way described above. Early speculation had MS possibly buying Facebook for $6 billion, but recent updates now have them in talks to acquire a 5% stake in the company, a move worth somewhere between $300 and $500 million. Word is that Google may also be a potential suitor.


text:
7779Re: APRS Location
Expand Messages
- Sep 3, 2007Jaye Ellen,
You need to do to things. First, you will adjusted your registered
location at CWOP, then enter the new cordinates in to WUHU.
If you go to the 'My summary' link under the CWOP section in WUHU, you
will be presented with a page to make adjustments to your location.
The map at the top right will contain a small red tag with your CWOP #
in it. You can then drag the marker around on the map. When you are
done moving it, your LORAN coordinates will be shown in text, at the
left side of the page.
Write down your new coordinates or save them to a file for later
reference. You will need to enter these values in to WUHU.
Click the 'send the updated information' on the page. This will send
the CWOP adiminstrators the information. Specify your email address in
case they need to contact you.
On WUHU, hit Stop, enter the new LORAN coordinates. Hit start.
It may take a day or two before they can process your registered
location change.
--- In firstname.lastname@example.com, "Jaye Ellen"
<jaye.ellen@...> wrote:
> Hi---
> I was looking at my CWOP data, and noticed that my location is waaay
> from actual. Where must I go to correct it?
> Jaye Ellen, CW8481, KTNGALLA2
- << Previous post in topic Next post in topic >>


text:
Everything tagged
Latest from The Spokesman-Review
Killing cormorants to save salmon: 11,000 in crosshairs of controversial program
Oct. 1, 2015 in Outdoors, Sports on Page O1 Shots ring out, then there's a splash: Government agents gunning for double-crested cormorants have hit their mark again. Federal agents have stalked tiny uninhabited East Sand Island in the estuary … 1
B.C. residents push for more-stable reservoir levels as Columbia River Treaty is renegotiated
Aug. 9, 2015 in Idaho on Page A1 NAKUSP, British Columba – Crystal and Janet Spicer grew up in a white-frame farmhouse on 60 fertile acres along the Columbia River in Canada. Their father was a local legend … 36
Residents say Columbia's dams have affected area families, economy
Aug. 9, 2015 in Idaho on Page A8 On a crisp day in March, Charlie Maxfield walked the along the mudflats south of Nakusp, remembering places that were flooded when the reservoir behind Hugh Keenleyside Dam filled. Maxfield's …
Columbia Basin tribes lead effort to save lamprey
April 11, 2015 in City on Page A6 LAPWAI, Idaho – At the Nez Perce Tribal Hatchery, hundreds of eel-like fish slither in holding tanks, their black eyes twinkling in the dark water like something from a child's … 5
Avista's 2014 earnings up 73 percent
Feb. 26, 2015 in Business, City on Page A7 Last year was a busy one for Avista Corp. The Spokane-based utility celebrated its 125th anniversary, bought an electric utility in Alaska and sold off a subsidiary. 22
State Senate GOP seeks to change clean energy rules
Feb. 6, 2015 in City on Page A9 OLYMPIA – Republican legislators want to change the state law that says rivers and streams are not a renewable energy source. A Senate bill would allow electric utilities to spend … 11
B.C. official calls for Columbia River Treaty accounting
Oct. 23, 2014 in City on Page A5 In the 1960s and 1970s, three huge dams were built in British Columbia to hold back the flow of the Columbia River. The entire Northwest still benefits from their construction. … 53
Landers: Foam-line fishing gets fly fishers salivating
Oct. 2, 2014 in Outdoors, Sports on Page O1 Saturday was scum bag day on the Clark Fork River. I've had better days of trout fishing in terms of fish caught.
Historic deal requires Corps disclose dam pollution
Aug. 4, 2014 in City, Region For the first time in its history, the U.S. Army Corps of Engineers will have to disclose the amount of pollutants its dams are sending into waterways in a groundbreaking … 1
Field Reports: Lookout Pass expansion proposals presented
April 20, 2014 in Outdoors on Page C11 SKIING – An open house meeting to present proposals for expanding Lookout Pass Ski Area is set for 5-7 p.m. on Thursday at the Idaho Panhandle National Forest Supervisor's Office, … 3
Deep drawdown: Lowering water levels test patience and ingenuity of local fishermen
April 10, 2014 in Outdoors on Page O1 Spokane anglers Jim Kujala and Dave Ross kicked butt on Lake Roosevelt rainbows all winter, catching their five-fish daily limits in as little as 20 minutes occasionally with the help …
U.S., Canada clash over Columbia River Treaty agendas
Nov. 20, 2013 in City, Region on Page A7 Vast mudflats appear in British Columbia's Lake Koocanusa when the reservoir is lowered to protect U.S. communities from flooding. Houseboats moored on the reservoir get mired in the muck. And … 1
Elwha River sees chinook salmon run increase
Nov. 17, 2013 in Region on Page B7 PORT ANGELES, Wash. – The largest run of chinook salmon in decades returned to the Elwha River this fall, according to officials with the Olympic National Park. Fish are streaming … 3
Kokanee won't run Lake Pend Oreille dam level
Nov. 10, 2013 in Outdoors on Page C11 Kokanee no longer pack enough influence to keep the U.S. Corps of Engineers from fluctuating water levels at Lake Pend Oreille during winter. Since 1996, the lake level behind Albeni …
Dam's removal should boost steelhead trout
Sept. 8, 2013 in Idaho, Outdoors on Page B10 TROY, Idaho – A Troy city crew began chiseling away at the long-forsaken Dutch Flat Dam on Wednesday to clear the way for steelhead trout seeking larger bodies of water … 1
'Clean Hydro' campaign hopes to build dam support
Sept. 5, 2013 in Idaho on Page A5 A coalition of utilities, river ports and farm organizations has embarked on a three-year, $3 million effort to improve Northwest residents' perception of dams. The "Clean Hydro" campaign kicked off … 37
Boundary Dam relicensing will boost recreation
March 24, 2013 in Outdoors on Page C14 The Federal Energy Regulatory Commission this week approved a new 42-year license for Boundary Dam on the Pend Oreille River north of Metaline Falls. Built in 1967, Boundary is the …
Free-flowing Elwha rallies fish
Sept. 2, 2012 in Outdoors on Page C13 PORT ANGELES – Scientists knew oceangoing fish would eventually return to the Elwha River on Washington state's Olympic Peninsula, once two massive concrete dams were torn down. They just didn't …
Unusual alliance allows beaver relocation
Aug. 23, 2012 in City on Page A5 It took more than six years, several legislative struggles, a raft of sniggering jokes, and the unlikely alliance of a conservative Eastern Washington Republican and a progressive environmental group, but … 5
Proposal streamlines retrofitting of nongenerating dams
July 13, 2012 in City on Page A7 WASHINGTON – The nation could get new electricity from old dams, saving time and money compared to damming new streams, under a bill that passed the House unanimously this week. …
Congress eyes old dams as new power sources
July 12, 2012 The nation could get new electricity from old dams, saving time and money compared to damming new streams, under a bill that passed the House unanimously this week. The Hydropower … 6
UI posts dam files online
May 28, 2012 in Idaho on Page A8 LEWISTON – Some predicted that salmon and steelhead runs would be wiped out, bountiful big-game herds would crash and a beautiful canyon would be turned into a mud-lined reservoir. Others …
High court sides with power company over Montana dams
Feb. 22, 2012 in Region WASHINGTON — The Supreme Court has sided with a power company in a dispute with Montana over who owns the riverbeds beneath 10 dams sitting on three Montana rivers. 5
Field reports: Public meeting set on fishing proposal
Oct. 23, 2011 in Outdoors on Page C11 FISHING – The Washington Fish and Wildlife Department is taking comment on proposed changes to sportfishing rules. A public meeting has been set for agency staff to discuss proposals 6-8 …
Federal judge rejects latest salmon protection plan
Aug. 3, 2011 in City on Page A5 A federal judge in Oregon ruled Tuesday the Obama administration's attempt to make federal hydroelectric dams in the Northwest safer for protected salmon once again violates the Endangered Species Act. … 1
Field reports: Local geese herded for population study
June 19, 2011 in Outdoors on Page C9 WILDLIFE – Biologists and volunteers herd Canada geese into pens and clamped leg bands on about 1,000 young birds in Eastern Washington in the past week for a Washington Fish …
Dam in southwest Washington slated for removal
June 14, 2011 in Outdoors, Region Nearly a century after it was built, the Condit Dam on the White Salmon River is about to be removed, reopening the Columbia River tributary for the passage of salmon … 7
Lawyers argue salmon numbers
May 10, 2011 in City on Page A6 PORTLAND – In what is likely the final major hearing before a federal judge decides what must be done to make Columbia River dams safe for salmon, lawyers argued Monday … 1
Condit Dam removal will free White Salmon rapids for rafters
May 1, 2011 in Outdoors on Page C10 Condit Dam towered over Mark Zoller, his crew of three, and the rafts they'd just wrestled down a catwalk and a cliff to reach the White Salmon River near Underwood, …
Runoff prompts Avista to open Post Falls gates
Jan. 19, 2011 in Idaho The huge runoff from recent thaw has prompted Avista Utilities to open all of its spill gates at Post Falls Dam, the utility said today.


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Explore the world of Skedaddle road cycling holidays in Italy and you'll find a range of tours to suit every level of road cyclist.
The mighty Dolomites will suit those after a challenging tour, whilst the Lakes of Lombardia and Tuscany will attract those after a less 'full-on' trip, but in never-the-less in stunning surroundings and those looking for rolling coastline road cycling will love Sardinia.
Found 11 holidays
This superb tour has become our signature road cycling holiday and deservedly so with its miles of great classic riding; it really is a distinctly varied cycling adventure which showcases some of the the best of coastal cycling in France and Italy. Following arrival and an evening of fine Niçoise cuisine on the French ... .. Read More
A coastal road cycling holiday in Italy on the island of Sardinia. Famed as Italy's most exotic island, it is blessed with a fantastic network of well-surfaced and car-free roads and you'll be assured of some great cycling. The island has a stunning coastline which we will explore throughout this cycling tour. Starting in th... .. Read More
This is a great example of a challenging road cycling holiday in Italy that visits the Italian Alps and the mighty Dolomites. Huge castles, vineyards and dramatic mountain peaks mark the far north of Italy as a genuinely special riding destination. To the north are the High Alps of Austria, to the west the Swiss Alps and to the ... .. Read More
A superb road cycling holiday in Italy which explores the Nothern Lake District, an area synonymous with cycling history. The Giro d'Italia almost always visits the region and, perhaps even more famously, it is the setting for the Tour of Lombardy, or "the race of the falling leaves", the Autumnal one-day classic which, each yea... .. Read More
An easy paced road cycling holiday in Italy that explores one of the country's premier cycling locations. Tuscany - the word itself is evocative, conjuring images of classic Italian landscapes, rolling hills, cypress trees and medieval hill-top towns. The region also offers superb cycling and is an international training gro... .. Read More
Our road cycling holidays in Italy have never been more popular and Sardinian Mountains is proving to be a great road cycling alternative to our ever popular Sardinia Coastal Explorer holiday. The island of Sardinia is a beautiful Mediterranean gem famous worldwide for its sea and its coasts, yet more than 80% of its territory i... .. Read More
Piemonte is the destination for this road cycling holiday in Italy. Situated in the far north western corner or Italy, surrounded by the Alps and sharing borders with France and Switzerland it is something of a hidden gem for cyclists. Almost half of Piemonte can be described as mountainous whilst most of the remainder is co... .. Read More
A fantastic road cycling tour in the undiscovered mountains of the Garfagnana region of Northern Tuscany in Italy. The chances are that you won't have heard of this region of Italy, but this is good for us, as it allows us to get off the beaten track of "tourist" Tuscany, yet we're close enough to still reap the advantages. ... .. Read More
Cyclist Howard Morgan never believed he'd be following in the footsteps of the pro peloton, that was until he met Skedaddle and we helped him tackle one of the worlds most dramatic road cycling challenges – the Stelvio Pass. Howard … Continue reading
Last Updated: 21/07/2015
Time for an Italian odyssey! Our newest iconic journey has been finely tuned and expertly crafted to provide a once in a lifetime tour of this sensational destination. Starting in the North, the Grand Traverse begins in magical Venice, one of the … Continue reading
Last Updated: 18/05/2015
Having thawed from winter's grip, the colossal peaks of the Alps are once again beginning to be eyed enviously by many road cyclists keen to tackle a legendary alpine col, or two… For newcomers to the mountains, Classic Alps Passes provides great instruction and the … Continue reading
Last Updated: 14/04/2015
Looking for that elusive 'once in a lifetime' trip? Time to get yourself booked onto an iconic journey! All of our long distance trips combine carefully selected routes hand picked by our guides, daily delicious and show stopping picnics, as well as … Continue reading
Last Updated: 23/03/2015
Saddle Skedaddle Ltd is registered in England and Wales with registered number 03719782.
The company's registered office is The Cycle Hub, Quayside, Newcastle Upon Tyne, England, NE6 1BU
Saddle Skedaddle is a member of ABTOT - Membership Number: 5111
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text: Being Human at HDIL Couture Week 2010 Fashion, Features, Stars | October 11, 2010 | | by Prathna Tiwari EmailFacebookTwitterPinterest Sushmita Sen rolled out in an outfit that was as vibrant as her! The mother of two gives all the newbies a run for the money and reminds us why she is the ultimate beauty queen! EmailFacebookTwitterPinterest


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... and we are SOLD OUT
Boom! We have noted the record in the Dragon Swing's history!
r/>3 weeks from the registration opening and we have almost 1000 bookings from 35 countries!
We are flattered and happy that so many of y [ ... ]
The registration for Dragon Swing 2015 is closed. We are SOLD OUT. There are long waiting lists for all tracks, party passes and weekend party passes. The registration form is still available, but now you can only sign up for one of the waiting lists.
* * * * *
What will wait for you between 18 and 22 November 2015?
5 parties (from Wednesday till Sunday) in 3 venues. You will have a chance to dance in breathtaking Old Tram Depot and legendary Salt Mine (125 meters underground!) in Wieliczka to 3 bands: Leliwa Jazz Band, Jazz Band Ball Orchestra and first time in Poland - Django Sisters and their boy band from Brno! Theme of suprise Sunday party? Hawaiian holidays :)
4 days of workshops with best instructors. We've already anounced some of them (you can check it out here), but we have some more stars to present... Which level of Lindy Hop group are you gonna choose? Or maybe you'll try to pimp up your solo dancing on Authentic Jazz classes? If it's still not enough for you, we offer a variety of taster classes before every party.
High level of competitions. Every year videos from the show reach very high rate of views (Jack'n'Jill finals from 2013 has over 700 thousands now!). You can chose Jack'n'Jill on two levels (Rising Stars /open/ and Shining Stars /advanced/), Strictly Lindy or Solo Jazz competition. Prizes? Glory, Golden Dragon statuette and passes for best dance events. Even if you are not eager to participate, you won't regret to see this excellent show live.
Remember, 1st August is the first day of registration! You can't miss it!
PS. Green Dragon Choreography Challenge 2015 is on. Together with www.lindyhopmoves.com we organize competition for the best choreo. The winners will get the full pass for Dragon Swing 2015, accomodation, meals, Green Dragon Trophy, chance to teach their choreography during the festival and... perform with it in Salt Mine! Dedline: 1st October. Good luck!
Boom! We have noted the record in the Dragon Swing's history!
r/>3 weeks from the registration opening and we have almost 1000 bookings from 35 countries!
We are flattered and happy that so many of y [ ... ]
Ladies and Gentlemen! KMiTa Swing team is happy to inform that the registration for Dragon Swing - Lindy Underground starts at 8 P.M CET on the 1st of August 2015. More information soon. Save the [ ... ]Read more
Dear Friends!
Lindyhopmoves.com and Dragon Swing have joined forces for the fourth time to bring you the Green Dragon Teaching and Choreography Competition. You will have a unique opportunity to wi [ ... ]
Every year we try to make our festival better and more diverse, thus gives us more difficult and ambitious projects but also lets the festival to develop. This year we focus on making a video, which w [ ... ]Read more
We are very pleased to announce that our video - Jack'n Jill finals shot during Dragon Swing 2013 in the Wieliczka Salt Mine has now over 100 thousands views on youtube! 294 people like this video, 18 [ ... ]Read more


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Premier League
'Man Utd fed up with Memphis' attitude'
Two ex-Netherlands internationals have blasted the attacker for failing to perform for his new club and his country in Euro 2016 qualification
Two ex-Netherlands internationals have blasted the attacker for failing to perform for his new club and his country in Euro 2016 qualification
Lyon's head of recruitment Gerard Bonneau, the man responsible for the striker's development, explains how the 19-year-old shined from an early age
In keeping with Gillette's Flexball Technology theme, we take a brief look at how Henderson fought for his place at Liverpool and eventually rose to captain the side.
The 22-year-old admits he can get advice from Arsenal's all-time record goalscorer in order to boost his own tally
The Manchester City man was over the moon after a triumph on Tuesday secured number one spot in the next world rankings, as well as taking the summit in Group B
The striker lasted just 20 minutes of the Albiceleste's qualifier against Ecuador before suffering the muscle tear, and he sent a message to his colleagues via Twitter
The Gunners boss believes that watching a player in away games gives a good indication of their character, bravery and desire
The Frenchman has revealed that he felt compelled to leave Old Trafford in 2014 because the Premier League side changed the terms of his contract
The former Tottenham Hotspur boss says the Anfield club spoke to the former Real Madrid boss but he was not interested in succeeding Brendan Rodgers
Manchester United's iconic red is outmuscled by teams lower down the English pyramid, while Newcastle United are nowhere to be seen in the North East. How about your club?
Adam Lallana, Danny Ings and Nathaniel Clyne rejoined the squad after returning from international duty, as well as midfielder Emre Can and goalkeeper Adam Bogdan
The Arsenal striker has defended the manager's record, saying he has done "a great job" at the club, and highlighted the Frenchman's willingness to nurture players
The Blues boss was spotted at the European Championship holders win over Ukraine, but the attacker insists he did not know the Portuguese coach was in the stands
In another fantastic revelation from the manager's autobiography, the 60-year-old dressed up as the singer, Michael Jackson and more all in the name of charity
The Everton midfielder strengthened his case for a place in Roy Hodgson's squad next summer with another effervescent midfield display
The 1986 World Cup winner had been offered the chance to lead an non-governmental organisation aimed at giving opportunities to kids in Latin America
Igoris Pankratjevas wasted no time in ending his spell as the national team boss following a Euro 2016 qualifying defeat to the Three Lions
England make it the perfect 10 as they wrap up their Euro 2016 qualification process with a 3-0 win over Lithuania
Ross Barkley, Alex Oxlade-Chamberlain and an Arlauskis own goal saw the Three Lions past the Baltic nation, ensuring a blemish-free record at the end of Group E
Roy Hodgson's side will be playing on an artificial surface in their final Euro 2016 qualifier and the pitch has been heavily watered before kick-off...
The 26-year-old Gent striker has been linked with a move to White Hart Lane but his representative insists talks have not begun
Despite speculation linking the old BVB favourite with a swoop for players including Marcos Reus and Ilkay Gundogan, the club's chief said he would not risk his good name
Philippe Coutinho, Daniel Sturridge and James Milner were among the players who took part, with several others away on international duty or suffering from injuries


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Resolution: standard / high
Figure 1.
TST measurements of Dunning rat CaP aggregates. Comparison of aggregate cohesion by TST shows that aggregates composed of a 4:1 mixture of JHU-3: Rat-2 and AT-2: Rat-2 are significantly more cohesive than those of MLL: Rat-2 (ANOVA, p < 0.0001, Tukey's MCT, JHU-3:AT-2 p < 0.001, JHU-3-MLL p < 0.001, AT-2:MLL p < 0.001). The data set is comprised of n = 20 JHU-3, n = 21 AT-2, and n = 20 MLL aggregates, representing 40, 42, and 40 compressions, respectively (A). Aggregate cohesion is independent of volume. The relationship between σ and aggregate volume was assessed by linear regression analysis. For liquid-like aggregates, σ must be independent of volume. This was confirmed by showing that the correlation coefficient, R2, of regression lines for MLL, AT-2, and JHU-3 are 0.23, 0.06, and 0.07, respectively, indicating that σ is independent of volume (B).
Jia et al. BMC Cancer 2012 12:94 doi:10.1186/1471-2407-12-94


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PR: Quest Rah 'Ancient Tapes Volume 2 - The Lost Art' - OUT NOW
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Laughing Lizard Inn
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- Pets allowed
TripAdvisor Reviews Laughing Lizard Inn Jemez Springs
Travel Blogs from Jemez Springs
Picnic in the Mountains
... from a big puddle/pool near by and they were freezing. We got them stripped off and got their clothes beginning to dry by the fire while they huddled up under a big cuddly blanket.
We had some liquid refreshment then Reid fired the barbie up and got burgers and hot dogs on the go. Yummy! After lunch Christy went for a walk with her Skikes (ski/skates) - looked a bit too difficult for me. Ryde and Peak were racing around on their bikes and then Peak began to ...
18. Cuba to Grants (2 days, 120 miles)
... as we will pass only one cafe in Pie Town over the next six days until we arrive in Silver City. We're camped at the KOA - something we swore never to do after Butte as it's so expensive - but we've got hot water, showers, wifi, an electric stove and a free breakfast for that. Tomorrow is another long day, and our bikes are going to weigh a ton with all the food we're carrying. But the weather looks solid again (fingers crossed). The end is getting closer ...
17. Abiquiu to Cuba (2 days, 80 miles)
... happens a fair bit). We've booked into the motel for two nights. We need a rest after a day like today, not to mention washing and drying all of our kit - clothes, tent, bikes, cook set, everything. It seems amazing now that we rode for forty days without having to have any emergency hotel stops - just the rest day in Pinedale at day 34. It always feels a bit disappointing to lose the purity of effort which the self-supporting tent and stove represent - living just ...
Sledding Down a Sand Dune
... The king-sized memory foam bed with super-soft pillows and blankets was so inviting that we could have just spent the entire day in the room. Cody wasn't allowed in the lodge, but he waited outside the door ever so patiently.
We took a little break, and then we got take-out from a little restaurant called River's Edge before heading to Spence Springs. We had to hike about a quarter mile, and we were out of breath almost the entire way. ...
Enjoying Los Alamos NM
... Lynne have sweet friends surrounding them. :) After dinner we headed to the Clarkson house and got all "moved in", watched a movie and then headed to bed. Amazingly, after all our driving, we all had energy and felt great! I'm sure the shear excitement of being here in New Mexico with our family contributed to a LOT of that, but God certainly has blessed our trip thus ...


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An Inventory of the Historical Monuments in Hertfordshire
Flaunden 46. FLAUNDEN. Note.The plan is reproduced by permission ... Ecclesiastical Flaunden Church b(1). Old Church of St. Mary Magdalene, ruins, ... by the same founder, and of the same date,...
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Sheet 039
Map of Buckinghamshire
Ashley Green, Bellingdon, Belsize, Botley, Bourne End, Bovingdon, Boxmoor, Chesham, Felden, Flaunden, Hogpits Bottom, Ley Hill, Lye Green, Newtown, Waterside, Whelpley Hill, HP5 3, HP5 2, WD3 4, HP1 2, HP3 0, HP5 1
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Sheet 038
Map of Hertfordshire
Belsize, Botley, Bovingdon, Bucks Hill, Chandler's Cross, Chenies, Chipperfield, Flaunden, Hogpits Bottom, Kings Langley, Latimer, Ley Hill, Little Chalfont, Micklefield Green, Sarratt, WD3 4, HP5 3, HP3 0, WD4 9, WD3 6, WD4
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The hundred of Dacorum: Introduction
A History of the County of Hertford: Volume 2
AND FLAUNDEN SHENLEY ALDENHAM STUDHAM (Part of) BERKHAMPSTEAD TRING with LONG ... Gaddesden, and Flaunden. Caddington and Kensworth were transferred in 1897
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List of Illustrations
An Inventory of the Historical Monuments in Hertfordshire
House: interior 76 FLAUNDEN. The Church: plan 89 GILSTON. The Church:
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Memorials: 1367
Memorials of London and London Life in the 13th, 14th and 15th Centuries
tenements, and rents, which formerly belonged to John Flaundene, hosyer; ... and to come, that I, John de Flaundene, hosyer, have given and granted, ... confirmed, unto John de Flaundene, hosyere...
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Corrigenda to volumes I, II, and IV
A History of the County of Middlesex: Volume 5, Hendon, Kingsbury, Great Stanmore, Little Stanmore, Edmonton Enfield, Monken Hadley, South Mimms, Tottenham
'Flaunden' " " 100 b, lines 13-15 from end, for 'the Metropolitan line, ... Green, for 'Flanders Green' read 'Flaunden' " " 279 b, s.v. Keane,
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Parishes: Hemel Hempstead
A History of the County of Hertford: Volume 2
AND FLAUNDEN Hamelamestede (xi cent.); Hemstede (xii cent.); Hamele Hamstede ... of Flaunden and Bovingdon have been counted as separate parishes, and the area ... acres in Flaunden. Prior to...
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List of Monuments Especially Worthy of Preservation
An Inventory of the Historical Monuments in Hertfordshire
FLAMSTEAD. Ecclesiastical:(1) Parish Church of St. Leonard. 46. FLAUNDEN
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Index: F
Calendar of Close Rolls, Edward I: Volume 4, 1296-1302
[co. York], 258, 380. Flanden. See Flaunden. Flanders, 13, 15, 23, 30, ... Flaunden, Flanden [co. Herts], 129, 191. Flaxley, Flaxle, Flaxeleye, co. ... 130. Flocker, Reginald, 512. Floggeres, Simon de, of...
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Below is a selection of search results matching: Remedial Massage Aranda
Rebekah Biggs Massage Therapy
Aranda, Australian Capital Territory
Are you stressed? Injured from weekend sport? Suffering RSI? Or do you just need to relax for an hour or so? Rebekah Biggs Massage...
02 6251 8231
0418 642 705
Anne Whish-Wilson
Mckellar, Australian Capital Territory
Acupressure focuses on relieving pain and discomfort before constrictions and imbalances can do further damage to your wonderful and...
Anne Whish-Wilson
02 6258 8218
Nurturing Hands - Canberra Massage Therapy
Kaleen, Australian Capital Territory
Massage Therapy Services at Nurturing Hands Canberra
Canberra Massage Therapy
02 6241 6716
0418 659 155
Jing Zheng
Kaleen, Australian Capital Territory
Special in Pain Management and Gynaecology and IVF Assistance and Chronic Diseases Treatment
Jing Zheng
(02) 6241 0578
Myo Yoga
Belconnen, Australian Capital Territory
Myo Yoga is designed to move you out of chronic pain into strength and confidence. Back pain can creep up slowly and twinges are warning...
Lai Morris
0401 177 299
Scenar Sports & Wellness
Evatt, Australian Capital Territory
At Scenar Sports & Wellness you can enjoy a Tranquil Environment and safe space. SCENAR Therapy, BOWEN Therapy, PLEXUS SLIM, RENU28 -...
Helene Nash
0404 326 130
Therapeutic Planet
Melba, Australian Capital Territory
Tummy troubles; Balanced diet; Weight management; Hayfever/Skin irrititations; Tiredness; Stress / Insomnia; Comprehensive Health...
John Warouw
02 6259 1443
02 6259 1443
Belconnen Massage Clinic
MacGregor, Australian Capital Territory
Canberra's Belconnen Massage Clinic offers Remedial, Deep Tissue, Reflexology, Sports, Pregnancy, and, Neck and Shoulder Massage - call...
02 6161 2367
0410 485 916
Canberra Day Spa
Canberra City, Australian Capital Territory
No matter what type of Massage Treatment you're after, we here at Canberra Day Spa are the ones to call. Gift Vouchers are also available.
02 6257 9511
Canberra City Osteopathy Physiotherapy on London
Canberra, Australian Capital Territory
Our services are provided by a range of professionals in osteopathy, physiotherapy, massage therapy and lymphatic drainage.
02 6247 0733
Therapy Masters
Canberra, Australian Capital Territory
Massage - Remedial, Aromatherapy, Cupping, Lymphatic Drainage, Massage - Connective Tissue, Massage - Corporate / Workplace, Massage -...
02 6247 0662
CJ Myjak Massage Therapy
Canberra, Australian Capital Territory
Qualified Remedial Male Massage Therapist Health Fund Accredited Swedish/Relaxation, Deep Tissue/Sports, Mobile, Corporate and...
CJ Myjak
Being In Health
Canberra, Australian Capital Territory
Remedial Massage | Sports Massage & Myofascial Release | Thai Massage | Lymphatic Drainage Massage If you are experiencing anxiety or...
Stefan Presetti
02 6251 5156
Hilary Bridgen Massage Therapy
CANBERRA, Australian Capital Territory
Massage - Remedial, Lymphatic Drainage, Massage - Corporate / Workplace, Massage - Deep Tissue, Massage - Indian Head, Massage - Mobile...
0412 678 212
Merilyn Jenkins Naturopath
Dickson, Australian Capital Territory
Merilyn has 18 yrs success in treating ailments like eczema, asthma, womens health, childhood ailments, anxiety, headaches, family first...
02 6247 6483
Massage For Health - Ainslie Shops
Ainslie Shops, Ainslie, Australian Capital Territory
Massage for Health is one of Canberra's leading massage clinic's and specialises in remedial and relaxation massage. At Massage for...
Massage for Health
02 6257 0388
O'Connor Massage
O'Connor, Australian Capital Territory
Massage - Remedial, Massage - Swedish / Relaxation
Anton Dennis
0417 663 262
Enhance Healthcare - Chiropractic and Massage Sports Injury Centre
Mitchell, Australian Capital Territory
Chiropractic and Massage Sports Injury Centre located in Mitchell, ACTServices include Chiropractic, Massage, Acupuncture, Exercise...
02 6241 6060
0448 925 032
Artemisia Natural Health Clinic
Turner, Australian Capital Territory
Soothe Away Your Aches and Pains and Perform At Your Best
Lesa Schuster
02 6262 5252
0400 404 402
Optimal Health Centre Braddon Pty Ltd
Braddon, Australian Capital Territory
Holistic Care: helping you reach your full potential
Drs Jason and Judy Barritt
02 6162 2919
Servicing Aranda
Study the science of rest and rejuvenation when and where you want with AIAS
Servicing Aranda
Follow your heart to a career in Natural Medicine and enrol at Endeavour College of Natural Health. Be provided with skills and knowledge to apply fundemental massage techniques. Payment Plans available.
Servicing Aranda
Gain an industry recognised qualification at ACNT. With flexible study option in Brisbane, Sydney and online, the Diploma of Remedial Massage will prepare you for a rewarding career in massage therapy. Study now, pay later...
Servicing Aranda
Begin massaging professionally and legally after successful completion of this course for total cost $595.00 . We are so confident you will enjoy your course and learn the skills needed to kick start your career that this...
Servicing Aranda
Learn How To Prevent Injury, Treat Pain, Manage Dysfunction & Maintain Musculoskeletal Health With Our Diploma of Remedial Massage. Let This Year Mark The Beginning Of Your Exciting Massage Career!
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ACFBs Diploma of Remedial Massage course is the next step in your journey to becoming a great Massage Therapist.
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This 5 day introductory Massage Certificate course allows students to quickly develop their skills and begin to massage effectively, assisting their client's healing journeys
Servicing Aranda
Learn Sports and Remedial Massage Online for only $719 Affordable and Non-Government Accredited Training with Easy Payment Plans to suit your needs.


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Miniature golf is much more popular than miniature mountain climbing, which is just driving a flagpole into an anthill. Have big fun playing small golf with this Groupon.
Choose from Three Options
- $8 for three rounds of mini golf during one visit for two (up to a $16 value)
- $15 for three rounds of mini golf during one visit for four (up to a $32 value)
- $19 for three rounds of mini golf during one visit for six (up to a $42 value)

Seniors and children aged 4 and younger can regularly purchase three games for $3.

With iridescent miniature golf courses in malls throughout North America, Glowgolf adds elements of phosphorescent fun to shopping sessions. Courses contain sights such as light-defying blush corals, incandescent animals, and lush foliage reminiscent of the glowing trees on Neptune. Each pass is good for three 18-hole games, giving golfers ample opportunity to get familiar with each hole's obstacles. Equipment is available on the spot, so players won't have to carry around personal clubs or seek out a bioluminescent caddie.
77% of 5,875 customers recommend
"Great place to go when the weather's not ideal! Wear cool clothes to add to the glow in the dark experience We had a blast at a very inexpensive price thanks to Groupon"
"Great cheap fun!"
"This place was awesome and the ladies working were really friendly! They were super nice and the lazer maze was a ton of fun for all ages!"
49 Maryland Street
Indianapolis, IN 46204
+13179552808Get Directions


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Community Sites are a new type of site introduced in SharePoint 2013, if you are unfamiliar the following article has some background information on their purpose and functionality - http://technet.microsoft.com/en-us/library/jj219805(v=office.15)
That's crazy. Thanks for the trick with the "Reporting" feature.
is there any chance to give access people to read these reports without granting them as site collection Administrators?


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Book your room at Towada Prince Hotel
Please enter your travel dates.
Get an overview of this hotelLakefront hotel with restaurant and coffee shop/café
Situated on a lake, this hotel is 5 mi (8 km) from Hakka Pass Observatory and within 12 mi (20 km) of Statue of Maidens and Mt.Ohanabe Observatory. Towada-Hachimantai National Park and Choshi Ohtaki Waterfall are also within 12 mi (20 km).
Hotel Features
Along with a restaurant, this hotel has a coffee shop/café and outdoor tennis courts. Self parking is free. Additionally, free newspapers and a garden are onsite.
Room Amenities
Rooms boast deep soaking tubs and offer refrigerators and LCD TVs. Satellite TV, coffee makers, and hair dryers are among the other amenities available to guests.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Dining options at the hotel include a restaurant and a coffee shop/café. Towada Prince Hotel features hot springs and outdoor tennis courts. This hot springs hotel also offers a garden and complimentary newspapers in the lobby. Complimentary self parking is available on site.
- Breakfast available (surcharge)
- Coffee shop or café
- Free newspapers in lobby
- Garden
- Restaurant
- Outdoor tennis courts 2
- Tennis on site
- Free self parking
Free self parking
Room Amenities
- Air conditioning
- Phone
- Refrigerator
- Coffee/tea maker
- Private bathroom
- Bathrobes
- Free toiletries
- Hair dryer
- Bidet
- Slippers
- Shower/tub combination
- Deep soaking bathtub
- In-room safe
- Satellite TV service
Where to Eat
Lobby Lounge - This café serves breakfast and lunch.
Main Dining Room - This restaurant serves breakfast, lunch, and dinner.
Nearby Things to Do
Hot springs and outdoor tennis courts are featured at the hotel.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Hot springs on site
- Bicycle rentals on site
Hotel Policies
Check-in time ends at 11 PM
Check-in time starts at 3 PM
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
No cribs (infant beds) available
Optional extras
- Breakfast fee: JPY 2000 per person (approximately)
We should mention
The Japanese Ministry of Health, Labour, and Welfare requires all international visitors to submit their passport number and nationality when registering at any lodging facility (inns, hotels, motels, etc. ). Additionally, lodging proprietors are required to photocopy passports for all registering guests and keep the photocopy on file.