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Publications (63)181.9 Total impact
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ABSTRACT: Background: Paracetamol's (APAP) mechanism of action suggests the implication of supraspinal structures but no neuroimaging study has been performed in humans. Methods and results: This randomized, double-blind, crossover, placebo-controlled trial in 17 healthy volunteers (NCT01562704) aimed to evaluate how APAP modulates pain-evoked functional magnetic resonance imaging signals. We used behavioral measures and functional magnetic resonance imaging to investigate the response to experimental thermal stimuli with APAP or placebo administration. Region-of-interest analysis revealed that activity in response to noxious stimulation diminished with APAP compared to placebo in prefrontal cortices, insula, thalami, anterior cingulate cortex, and periaqueductal gray matter. Conclusion: These findings suggest an inhibitory effect of APAP on spinothalamic tracts leading to a decreased activation of higher structures, and a top-down influence on descending inhibition. Further binding and connectivity studies are needed to evaluate how APAP modulates pain, especially in the context of repeated administration to patients with pain.Drug Design, Development and Therapy 08/2015; 9:3853-62. DOI:10.2147/DDDT.S81004 · 3.03 Impact Factor
Article: Experimental pain processing in individuals with cognitive impairment: Current state of the science[Show abstract] [Hide abstract]
ABSTRACT: Cognitive impairment (CI) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with CI have substantial, sustained and complex healthcare needs which frequently include pain. However, individuals with CI can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with CI to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which CI is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with CI compared to cognitively intact matched controls. The precise nature of these alterations varies with the type of CI (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of CI, patients do feel noxious stimuli; with more evidence for hypersensitivity than hyposensitivity to these stimuli compared to cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited, but may be enhanced through the use of animal models of CI which also exhibit alterations in nociceptive responding. Further research employing additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in CI will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with CI.Pain 08/2015; 156(8). DOI:10.1097/j.pain.0000000000000195 · 5.21 Impact Factor
Article: A New Transmucous-Buccal Formulation of Acetaminophen for Acute Traumatic Pain: A Non-inferiority, Randomized, Double-Blind, Clinical Trial[Show abstract] [Hide abstract]
ABSTRACT: Acetaminophen (APAP) consumption is large and sometimes excessive, and guidelines suggest to diminish the dosage prescription. In emergency situations of mild/moderate pain intravenous (iv) APAP is recommended, but the route of administration is invasive. To determine the efficacy of a new transmucous-buccal (B) pharmaceutical form of 125mg-APAP in patients. To confirm the findings obtained in 2 previous clinical trials in healthy volunteers. A randomized, double-blind, non-inferiority, clinical trial (NCT01586143) was carried out from 03/05/2012 to 13/05/2013. The study took place in the Emergency Department of the University Hospital, Clermont-Fd, France. Forty-three patients were included and 40 analyzed. Patients were eligible if they had leg or arm traumatic pain of moderate intensity. Pain intensity was measured using a numerical scale (0 - 10) at regular times for 120 minutes and the main endpoint was at 30 minutes. The hypothesis of non-inferiority was formulated from previous works with healthy volunteers. After pain assessment, patients received at baseline 1 g-iv-APAP or saline and concomitantly, 125 mg APAP in 1 mL hydroalcoholic solution (HAS) or placebo (HAS only) was applied in the left mucogingival sulcus. Non-inferiority of the primary outcome was assessed by one-sided 2 group t-test of equivalence in means with equal variances with a non-inferiority limit difference of 1. Other tests were two-sided, with a type I error set at α = 0.05. Intention-to-treat analysis shows that pain intensity of B-APAP and iv-APAP groups were not significantly different at t30 minutes (3 ± 1.3 vs 2.7 ± 1.2, P = 0.23, one-sided Student t-test), and at any other times for 120 minutes. The difference of pain intensity between groups was 0.30 with 2-sided IC90% = [-0.38 - 0.98], not including the non-inferiority margin ( ∆ = 1). Time to exhibit a statistical significance in pain relief from baseline was reached at t10 for B-APAP (P = 0.03) and iv-APAP (P < 0.001). Patients preferred the buccal rather than the iv route of administration. Small population study with limited doses. For acute traumatic pain of moderate intensity, B-APAP has a non-inferior analgesic effect compared to iv-APAP for 2 hours. Such a pharmaceutical form would be useful in emergency situations and breakthrough moderate pain episodes. It would diminish APAP consumption per dosage unit, limit the risk of adverse events and toxicity, and adhere to actual guidelines of APAP prescription. It must be now studied in a larger population and with repeated doses. Transmucosal delivery, pain, trauma.Pain physician 05/2015; 18(3):249-257. · 3.54 Impact Factor
Article: Fibromyalgia, milnacipran and experimental pain modulation: Study protocol for a double blind randomized controlled trial[Show abstract] [Hide abstract]
ABSTRACT: Background The prevalence of fibromyalgia increases worldwide and is characterized by widespread and chronic pain. Treatment is difficult and includes both drug and non-drug approaches. Milnacipran, an antidepressant, is used for fibromyalgia, with a possible beneficial effect on central pain modulation. Our hypothesis is that the efficacy of milnacipran in fibromyalgia depends on the performance of pain inhibitory controls. Methods/design A randomized, double blind, clinical trial (NCT01747044) with two parallel groups, in 48 women with fibromyalgia, is planned in the Clinical Pharmacology Center, University Hospital, Clermont-Ferrand, France. Conditioned pain modulation (estimated with thermal stimuli using a numeric pain rating scale), the primary endpoint measure, is evaluated before and one month after treatment with milnacipran or placebo. Secondary outcome measures include the predictability of pain descending pathways performance for milnacipran efficacy, tolerance and cognitive function. Data analysis is performed using mixed models; the tests are two-sided, with a type I error set at alpha = 0.05. Not only will this trial allow estimation of the beneficial effect of milnacipran on pain and on descending pain pathways but it will also evaluate whether the performance of this modulatory system could be predictive of its efficacy in alleviating pain. Discussion This method would allow clinicians to take a pro-active attitude by performing a rapid psychophysical test before starting milnacipran treatment and would avoid unnecessary prescription while preventing therapeutic failure in patients who often face this recurrent problem. Trial registration ClinicalTrials.gov NCT01747044.Trials 04/2015; 16(1). DOI:10.1186/s13063-015-0659-4 · 1.73 Impact Factor
Article: Rationale and design of a randomized double-blind clinical trial in breast cancer: Dextromethorphan in chemotherapy-induced peripheral neuropathy[Show abstract] [Hide abstract]
ABSTRACT: Background: Anti-cancer chemotherapy often induces peripheral neuropathy and consequent cognitive and quality of life impairment. Guidelines recommend antiepileptics or antidepressants but their efficacy is limited.Dextromethorphan, a N-methyl-D-aspartate receptor antagonist, has shown its efficacy in painful diabetic neuropathy and in post-operative pain but has not been studied in chemotherapy-induced peripheral neuropathy. This clinical trial evaluates the effect of dextromethorphan on pain, cognition and quality of life in patients who suffer from neuropathic pain induced by chemotherapy for breast cancer. It also assesses the impact of dextromethorphan genetic polymorphism on analgesia. Methods and design: This trial is a randomized, placebo-controlled, double-blind clinical study in two parallel groups (NCT02271893). It includes 40 breast cancer patients suffering from chemotherapy-induced peripheral neuropathy. They are randomly allocated to dextromethorphan (maximal dose 90 mg/day) or placebo for 4 weeks. The primary endpoint is pain intensity measured after 4 weeks of treatment on a (0-10) Numeric Pain Rating Scale. Secondary outcomes include assessment of neuropathic pain, cognitive function, anxiety/depression, sleep and quality of life. Data analysis is performed using mixed models and the tests are two-sided, with a type I error set at α=0.05. Discussion: Considering the poor efficacy of available drugs in chemotherapy-induced neuropathic pain, dextromethorphan may be a valuable therapeutic option. Pharmacogenetics may provide predictive factors of dextromethorphan response in patients suffering from breast cancer.Contemporary Clinical Trials 01/2015; 41. DOI:10.1016/j.cct.2015.01.012 · 1.94 Impact Factor
Article: Buccal acetaminophen provides fast analgesia: Two randomized clinical trials in healthy volunteers[Show abstract] [Hide abstract]
ABSTRACT: Background Acetaminophen (APAP) by oral or intravenous (iv) routes is used for mild to moderate pain but may take time to be effective. When fast relief is required and/or oral or iv routes are not available because of the patient's condition, the transmucosal route may be an alternative. Methodology A new transmucosal/buccal (b) pharmaceutical form of APAP dissolved in 50% wt alcohol is compared with other routes of administration. Two consecutive randomized, crossover, double-blind clinical trials (CT1: NCT00982215 and CT2: NCT01206985) included 16 healthy volunteers. CT1 compared the pharmacology of 250 mg bAPAP with 1 g iv APAP. CT2 compared the pharmacodynamics of 125 mg bAPAP with 1 g iv and 125 mg sublingual (s) APAP. Mechanical pain thresholds are recorded in response to mechanical stimuli applied on the forearm several times during 120 minutes. The objective is to compare the time of onset of antinociception and the antinociception (area under the curve) between the routes of administration with analysis of variance (significance P<0.05). Results bAPAP has a faster time of antinociception onset (15 minutes, P<0.01) and greater antinociception at 50 minutes (P<0.01, CT1) and 30 minutes (P<0.01, CT2) than ivAPAP and sAPAP. All routes are similar after 50 minutes. Conclusion bAPAP has a faster antinociceptive action in healthy volunteers. This attractive alternative to other routes would be useful in situations where oral or iv routes are not available. This finding must now be confirmed in patients suffering from acute pain of mild and moderate intensity.Drug Design, Development and Therapy 09/2014; 8:1621-7. DOI:10.2147/DDDT.S63476 · 3.03 Impact Factor
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ABSTRACT: Post-herpetic neuralgia is a painful condition and its prevalence increases with age. It is a burden for older patients and the association of age-related pharmacokinetic and pharmacodynamic changes, high co-morbidity and polypharmacy leads to the risk of adverse drug reactions and interactions. This type of neuropathic pain is particularly difficult to treat and guidelines recommend the use of gabapentinoids and some antidepressants, the utility of which may be hampered by adverse effects such as sedation, dizziness and impaired age-related renal function. Re-formulations of antiepileptics (anticonvulsants) are being developed and/or marketed and suggest interesting innovative profiles with improved bioavailability, low drug-drug interactions and better tolerability that need to be confirmed in future studies. However, there are no new antiepileptics being developed for post-herpetic neuralgia, and prospective studies specifically focused on the older population are still missing, while this age group is particularly at risk of developing shingles and chronic neuropathic pain with a deleterious impact on quality of life.Drugs & Aging 09/2014; 31(9). DOI:10.1007/s40266-014-0202-4 · 2.84 Impact Factor
Article: Prevention of post-mastectomy neuropathic pain with memantine: Study protocol for a randomized controlled trial[Show abstract] [Hide abstract]
ABSTRACT: Background N-methyl-D-aspartate receptor antagonists are potential therapies for neuropathic pain, and memantine has a good tolerance profile. A preclinical study recently reported that presurgery memantine may prevent neuropathic pain development and cognition dysfunction. Considering the high prevalence of breast cancer and of post-mastectomy neuropathic pain, a clinical trial is carried out to evaluate if memantine may prevent neuropathic pain development and maintain cognitive function and quality of life in cancer patients. Methods/Design A randomized clinical trial (NCT01536314) includes 40 women with breast cancer undergoing mastectomy at the Oncology Hospital, Clermont-Ferrand, France. Memantine (5 to 20 mg/day; n = 20) or placebo (n = 20) is administered for 4 weeks starting 2 weeks before surgery. Intensity of pain, cognitive function, quality of life and of sleep, anxiety and depression are evaluated with questionnaires. The primary endpoint is pain intensity on a 0 to 10) numerical scale at 3 months post-mastectomy. Data analysis is performed using mixed models and the tests are two-sided, with a type I error set at α = 0.05. Discussion The hypothesis of this translational approach is to confirm in patients the beneficial prophylactic effect of memantine observed in animals. Such a protective action of memantine against neuropathic pain and cognitive dysfunction would greatly improve the quality of life of cancer patients. Trial registration ClinicalTrials.gov: NCT01536314 on 16 February 2012Trials 08/2014; 15(1):331. DOI:10.1186/1745-6215-15-331 · 1.73 Impact Factor
Article: Rationale and design of a multicenter randomized clinical trial with memantine and dextromethorphan in ketamine-responder patients[Show abstract] [Hide abstract]
ABSTRACT: The N-methyl-D-aspartate receptor plays an important role in central sensitization of neuropathic pain and N-methyl-D-aspartate receptor antagonists, such as ketamine, memantine and dextromethorphan may be used for persistent pain. However, ketamine cannot be repeated too often because of its adverse events. A drug relay would be helpful in the outpatient to postpone or even cancel the next ketamine infusion. This clinical trial evaluates if memantine and/or dextromethorphan given as a relay to ketamine responders may maintain or induce a decrease of pain intensity and have a beneficial impact on cognition and quality of life. This trial is a multi-center, randomized, controlled and single-blind clinical study (NCT01602185). It includes 60 ketamine responder patients suffering from neuropathic pain. They are randomly allocated to memantine, dextromethorphan or placebo. After ketamine infusion, 60 patients received either memantine (maximal dose 20mg/day), or dextromethorphan (maximal dose 90mg/day), or placebo for 12weeks. The primary endpoint is pain measured on a (0-10) Numeric Rating Scale 1month after inclusion. Secondary outcomes include assessment of neuropathic pain, sleep, quality of life, anxiety/depression and cognitive function at 2 and 3months. Data analysis is performed using mixed models and the tests are two-sided, with a type I error set at α=0.05. This study will explore if oral memantine and/or dextromethorphan may be a beneficial relay in ketamine responders and may diminish ketamine infusion frequency. Preservation of cognitive function and quality of life is also a central issue that will be analyzed in these vulnerable patients.Contemporary Clinical Trials 06/2014; 38(2). DOI:10.1016/j.cct.2014.06.004 · 1.94 Impact Factor
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ABSTRACT: Pain management in the elderly remains insufficient, be it at home, in nursing homes or hospitals. Inadequate evaluation and/or misinterpretation of the clinical signs present probably explain this poor management and are linked to the particularities of the old patient. Thus, recommendations to improve evaluation of pain in the elderly were formulated. However, these guidelines are rarely implemented in daily practice, most likely because they markedly increase the workload of the geriatric healthcare workers already required to perform multiple evaluations. Unfortunately, the dysfunctions observed are detrimental to the quality of life of these patients, and their morbidity and mortality. To improve pain management in the elderly, it is important to simplify the tasks of the different actors involved by proposing evaluation algorithms taking advantage of the complementarity of self-report and behavioral scales.Douleurs Evaluation - Diagnostic - Traitement 04/2014; DOI:10.1016/j.douler.2014.01.001
Article: Douleur, opioïdes et sujet âgé[Show abstract] [Hide abstract]
ABSTRACT: La médecine basée sur les preuves concernant les opioïdes chez le sujet âgé est encore très pauvre, mais les recommandations actuelles vont vers une utilisation individualisée des opioïdes et une adaptation du traitement en fonction des comorbidités et des autres médicaments. Considérant la forte augmentation de la prescription et de la consommation d'opioïdes chez le sujet âgé, une surveillance du risque de mésusage, de surdosage et d'abus doit être complétée par une éducation thérapeutique adaptée.Les cahiers de l année gérontologique 04/2014; 6(1). DOI:10.1007/s12612-013-0370-6
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ABSTRACT: The efficiency of inhibitory pain descending pathways (evaluated using conditioned pain modulation [CPM]) has not been studied in postherpetic neuralgia (PHN). To compare CPM in PHN patients with healthy controls. Nine PHN patients and nine control individuals were matched according to age and sex. Amplitudes of cortical thermal-evoked potentials were recorded on the surface of the scalp; clinical pain and thermal pain were evaluated on a 0 to 10 numerical rating scale, at baseline and at intervals during the 6 min after CPM (elicited by a cold pressor test, 8°C). A battery of cognitive tests was performed. Amplitude differences, percentages and related areas under the curve (AUC CPM<⁄span>) were calculated and all data were compared between both groups; P<0.05 was considered to be statistically significant. AUC CPM0-6 min<⁄span> was significantly lower in PHN patients compared with controls (-39±51 µV⁄min versus -144±66 µV⁄min; P=0.0012) and correlated (P=0.04) with clinical pain intensity. Pain ratings before CPM were similar in both groups but were significantly lower in the control group 3 min after the cold pressor test. Cognitive test results were not significantly different. Psychophysical and electrophysiological approaches have shown that patients with PHN exhibit a deficiency of pain inhibition modulation, which could signal a predisposing factor to developing chronic pain. This deficiency was not linked to the cognitive performance but rather to subtle in situ cognitivoemotional adaptations, which remain to be investigated.01/2014; 19(1).
Article: Oc028—A New Pharmaceutical Form Of Paracetamol: Efficacy Of Transmucous Buccal Paracetamol In Acute Pain PatientsClinical Therapeutics 08/2013; 35(8):e11-e12. DOI:10.1016/j.clinthera.2013.07.027 · 2.73 Impact Factor
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ABSTRACT: N-methyl-D-aspartate (NMDA) receptor antagonists are used for post-surgery neuropathic pain but severe side-effects limit their clinical use. Memantine, when given after surgery, shows conflicting results as regard neuropathic pain alleviation. Memantine is here administered in animals before or after spinal nerve ligation (SNL) in order to evaluate the induced antinociceptive/cognitive effects and associated molecular events, including the phosphorylation of several tyrosine (pTyr(1336), pTyr(1472)) and serine (pSer(1303)) residues in the NR2B subunit of the NMDA receptor. Spinal nerve ligated and sham animals received memantine (20mg/kg/day) or vehicle (1ml/kg/day) by intraperitoneal route. Pre-emptive protocol started 4 days before surgery and continued for 2 days post-surgery. In the post-operative protocol, the 7 day-treatment began on the day of surgery. Tests were done before and after surgery. Tactile allodynia, mechanical hyperalgesia and spatial memory were respectively evaluated by von Frey, Randall & Selitto and Y-maze-tests, and molecular events by western-blot analysis. Spinal nerve ligated animals displayed nociception, impaired memory and increased expression of the three phosphorylated residues. Post-operative memantine had no beneficial effect. Pre-emptive memantine prevented the development of post-surgical nociception, impairment of spatial memory and did not increase the expression of pTyr(1472)NR2B at spinal, insular and hippocampal levels. Memantine administered a few days before surgery is a promising strategy to alleviate neuropathic pain development and impairment of cognitive function in animals. The pivotal role of pTyr(1472)NR2B must be studied further, and these findings will now be challenged in patients for the prevention of postsurgical neuropathic pain.European journal of pharmacology 06/2013; 721(1-3). DOI:10.1016/j.ejphar.2013.06.020 · 2.53 Impact Factor
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ABSTRACT: BACKGROUND AND AIMS: Neuropathic pain has been shown to be accompanied by cognitive impairment, but the specific impact of postherpetic neuropathic pain on cognitive processes has not been explored. This study aims to evaluate the impact of pain on several domains of cognition in older patients with postherpetic neuralgia (PHN). METHODS: This cross-sectional study (clinicaltrial.gov NCT 00989040) included 84 individuals after signature of informed consent. Participants: 42 patients with PHN and 42 healthy volunteers. Of the 42 PHN patients, 21 received systemic treatment (antidepressants, anticonvulsants, opiates) and 21 had topical treatment with the 5% lidocaine medicated plaster. All participants performed a panel of four cognitive tests: reaction time, semantic memory, decision-making, and visual memory (Cantab(®) , Cambridge). RESULTS: Forty men and 44 women with a mean age of 72 ± 8 years participated. Each PHN patient was matched by age and gender with a healthy volunteer. Vigilance, decision-making, and semantic memory were significantly impaired (P < 0.05) in patients on systemic treatment, especially with antidepressants, while no significant changes were noted between the lidocaine plaster group and their matched controls of healthy volunteers. CONCLUSION: This study shows the deleterious effect of systemic PHN treatment on several domains of cognition. Cognitive impairment associated with pain and antidepressants may be reversed by topical pain management. Topical treatment with 5% lidocaine medicated plaster is a valuable alternative for pain alleviation and maintains cognitive integrity in this vulnerable population.Pain Practice 05/2013; 14(1). DOI:10.1111/papr.12079 · 2.36 Impact Factor
Article: Impact of Grapefruit Flavanone Consumption on Vascular Protection and Bone Metabolism: Clinical and Nutrigenomic StudyFree Radical Biology and Medicine 11/2012; 53:S169. DOI:10.1016/j.freeradbiomed.2012.10.465 · 5.74 Impact Factor
Article: Analgesic use in the older person[Show abstract] [Hide abstract]
ABSTRACT: To summarize developments in analgesic use in the older person. Observational studies, reviews and a few randomized trials dealing with analgesic use in the older person have been published during the past year. Recent trials examine also pharmacological/nonpharmacological interventions, and education of older patients as well as clinicians in pain management. Under-treatment of pain remains a major concern in community-dwelling or institutionalized older persons, especially with dementia. An increased awareness of pain and palliative pain management in the older person is present throughout the literature. Age-related factors affect the safety and efficacy of the analgesic treatment and pharmacological aspects are often underlined, especially when impaired cognition and frailty are present. The use of topical analgesics, well tolerated in older persons, allows reduction of concomitant treatments and of adverse events. Optimizing analgesic use in older patients is carried out by exploring motivations and attitudes of the patients, by analysing barriers and practices of clinicians and by setting up structured educational nursing interventions. Although a larger number of older persons are included in studies, prospective and large-scale trials are needed in this vulnerable population characterized by a high variability and heterogeneity.Current opinion in supportive and palliative care 03/2012; 6(2):207-12. DOI:10.1097/SPC.0b013e32835242d2 · 1.66 Impact Factor
Article: Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome[Show abstract] [Hide abstract]
ABSTRACT: The role of the gut microbiota in patho-physiology of irritable bowel syndrome (IBS) is suggested by several studies. However, standard cultural and molecular methods used to date have not revealed specific and consistent IBS-related groups of microbes. To explore the constipated-IBS (C-IBS) gut microbiota using a function-based approach. The faecal microbiota from 14 C-IBS women and 12 sex-match healthy subjects were examined through a combined strictly anaerobic cultural evaluation of functional groups of microbes and fluorescent in situ hybridisation (16S rDNA gene targeting probes) to quantify main groups of bacteria. Starch fermentation by C-IBS and healthy faecal samples was evaluated in vitro. In C-IBS, the numbers of lactate-producing and lactate-utilising bacteria and the number of H(2) -consuming populations, methanogens and reductive acetogens, were at least 10-fold lower (P < 0.05) compared with control subjects. Concomitantly, the number of lactate- and H(2) -utilising sulphate-reducing population was 10 to 100 fold increased in C-IBS compared with healthy subjects. The butyrate-producing Roseburia - E. rectale group was in lower number (0.01 < P < 0.05) in C-IBS than in control. C-IBS faecal microbiota produced more sulphides and H(2) and less butyrate from starch fermentation than healthy ones. A major functional dysbiosis was observed in constipated-irritable bowel syndrome gut microbiota, reflecting altered intestinal fermentation. Sulphate-reducing population increased in the gut of C-IBS and were accompanied by alterations in other microbial groups. This could be responsible for changes in the metabolic output and enhancement in toxic sulphide production which could in turn influence gut physiology and contribute to IBS pathogenesis.Alimentary Pharmacology & Therapeutics 02/2012; 35(7):828-38. DOI:10.1111/j.1365-2036.2012.05007.x · 5.73 Impact Factor
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ABSTRACT: Previous studies suggest that the antinociceptive action of paracetamol (acetaminophen, APAP) might involve descending inhibitory pain pathways and the opioidergic system: this study explores this issue in humans with naloxone, the opioid antagonist. After ethical approval, 12 healthy male volunteers were included in this randomized, controlled, double-blind, crossover, four-arm study. They were administered intravenous paracetamol (APAP 1 g) or saline (placebo, pl) followed at 100 min with IV naloxone (Nal 8 mg) or saline, every week for 4 weeks. The amplitude of cerebral potentials evoked by thermal/painful stimuli applied on the arm was recorded nine times over 150 min, witnessing of pain integration at central level. Amplitude changes as well as areas under the curve (AUCs) over 150 min were compared for the four treatments by repeated measures anova (significance 0.05). Amplitude changes were significant for APAP/pl vs. pl/pl at t(150) : -44% (95%CI -58 to -30) vs. -27% (95%CI -37 to -17; P < 0.05) but not vs. APAP/Nal. AUC (0-150) of APAP/pl is significantly different from pl/pl (-3452%.min (95%CI -4705 to -2199) vs. -933% min (95%CI -2273 to 407; P = 0.015) but not from APAP/Nal (-1731% min (95%CI -3676 to 214; P = 0.08) and other treatments. AUC (90-150) is not significantly different. This pilot study shows for the first time in human volunteers that naloxone does not inhibit paracetamol antinociception, suggesting no significant implication of the opioid system in paracetamol mechanism of action: this needs be confirmed on a larger number of subjects.Fundamental and Clinical Pharmacology 11/2011; 27(3). DOI:10.1111/j.1472-8206.2011.01010.x · 2.12 Impact Factor
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ABSTRACT: Patients undergoing major surgery represent a good model for the study of the hepatic metabolism of acetaminophen (APAP) after surgery and for the evaluation of how the detoxification process is influenced by aging. Thirty patients received intravenous APAP (1 g/6 h) for 4 days (D1-D4). Daily 24-h urinary metabolites-cysteine-APAP, mercapturate-APAP, APAP, and glucuronide and sulfate conjugates-as well as blood glutathione levels were compared with repeated-measures analysis of variance (significance, P<0.05). Between D1 and D4, cysteine-APAP increased (308±308 mg vs. 570±512 mg, P=0.005), and sulfate and glucuronide conjugates decreased (1,365±1,084 mg vs. 694±600 mg, P<0.0001 and 2,418±817 mg vs. 1,513±1,076 mg, P=0.011, respectively). Blood glutathione decreased (790±125 vs. 623±132 µmol/l, P<0.0001. These changes increased with aging. APAP disposition after major surgery shifts toward the oxidative pathways of metabolism, and this is enhanced with aging. Supplementation with sulfur-containing amino acids should be investigated further as it might minimize the effect on antioxidant defenses, especially in older persons undergoing more extensive surgical procedures.Clinical Pharmacology & Therapeutics 11/2011; 90(5):707-11. DOI:10.1038/clpt.2011.176 · 7.90 Impact Factor
Top Journals
University of AuvergneClermont, Auvergne, France
Université Blaise Pascal - Clermont-Ferrand IIClermont, Auvergne, France
Centre Hospitalier Universitaire de Clermont-FerrandClermont, Auvergne, France
Académie de Clermont-FerrandClermont, Picardie, France
Polytech Clermont-FerrandAubière, Auvergne, France
University Hospital Estaing of Clermont-FerrandClermont, Auvergne, France


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I Love Fashion
Personal Stories, Advice, and Support 5,403 People
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Oh my God! I'm dying over Miss Jamaica'sevening gown in the Miss Universe Pageant! So different than the usual pageant dress. In red lace with an extremely low back, it is divine.
Itsmytime2be 41-45, F 12 Jan 25
Earlier today I had to make an impromptumedical appointment to see my psychologist because of stress ailments again. We are determined to try to have my body, my heart and my brain not be physically or emotionally weathered and have it interfere with what is definitely going to be the biggest night of my life so far...
loveismyfriend 36-40, F 0 Sep 12
I love theese pants but I have no idea how towear them with
xkikasantosx 18-21, F 4 Responses 5 Jul 27
Yesterday (Saturday),I went out since I was awake and needed a break from stress ailments. I didn't do much, just enjoyed being out. I went to one of my favorite restaurants The Silver Diner and started to fall asleep there from being awake most of the night.I had already had a meal during the night...
loveismyfriend 36-40, F 1 Response 0 Aug 16
Over/under: Slipdresses Take The SpotlightThe slip (petticoat) was always such a practical and feminine item of clothing. It was a pity it went out of fashion. Worn beneath a dress or skirt it helped them to hang smoothly and to prevent chafing of the skin from coarse fabricssuch as wool. Slips are also worn for...
annehathaway22 22-25, F 2 Responses 3 Jan 16, 2013
(Picture attached) Tomorrow's outfitfor school. 💕 🍂🍁
BeautifulPetals 18-21, F 6 Responses 6 4 days ago
aliyakins 18-21, F 4 Responses 12 Aug 23
I cannot express how much I appreciate peoplewho are well put-together and own their sense of style with confidence. Fashion, whatever that may mean to you, is important and enjoyable for me.
brightstack 18-21, F 1 Response 4 Jan 11, 2014
I love European fashion.My personal style is very chic, sophisticated, and contains a large amount of black. I wear gold and platinum chunky jewelry and watches to accessorize. I love fur coats and vests. I'm a huge fan of boots with a 1 3/4 or 2 inch Cuban heel (Saint Laurent mens French boot or...
KingLouis317 18-21, M 0 Sep 27
(pic)I love fashion but I don't follow fashiontrends... err sounds weird? Have you seen the new collection of 'Jean Paul Gaultier - ready-to-wear collection, the 2015 Spring/Summer ready-to-wear collection' I was jaw drop. This is beyond my expectation.. not quite my cup of tea. Do you like it?
Swanlake78 36-40, F 2 Responses 5 Sep 29, 2014
I think this is a spectacular dive watch.What do you think?
snowwhitejrm 18-21, M 1 Response 1 Aug 26
Oh yesss.. Fashion makes senseand sense makes love for it 💓
fashoongeet77 26-30, F 1 Response 4 Jun 16, 2014
Hey, what do you think of this lace topand skirt from Nastygal?Cool or too much?
chloejustchloe 18-21, F 14 Responses 14 Aug 21
Are these glasses cool?Or nah?
KylieLaine 18-21, F 11 Responses 6 Jun 24, 2014
Help reccomend me some clothesfor school? I've worn uniform all my life and I hardly go out so I guess Im not very fashionable at all. I like clothes that have sleeves because I have broad shoulders and fat arms so I try to minimise them. I'm a size 12. I have nice legs so I like to show those off but never...
VioletSea 16-17, F 1 Response 0 Aug 27
(Cover image) I love to redesign outfitsthat I already own. For this outfit above, my skirt is actually a long scarf that I have and my top is my black corset.
SeductivePoetess95 18-21, F 2 Responses 12 Dec 11, 2014
i absolutely love fashion.and I like simple outfits. ..like this :)
Rika39 18-21, F 11 Responses 18 Sep 26
So I know it has been done before,but I just can't get over the show Reign's awesome fashion! I thought Reign's fashion would be nice for some fall fashion inspiration.
ERMAHGERD1 26-30, F 1 Response 5 1 day ago
Talking to a ep lesbian perv last night it soonturns them away when you mention that pulling your black thin strap top down to show off your cleveage while wearing a bright pink bra just so you get noticed. That is how to make them angry XD seriously don't do it! Big big turn off! Also wear a V-neck top to make a guy/girl...
lupuslupus87 22-25, F 1 Response 1 Sep 14
My birthday was August 7.I had a birthday party August 9. I wore a sleeveless babydoll dress with wide light yellow and wide light gray horizontal stripes with a large light yellow pocket on each side of the dress. The dress had a high rounded neckline and went to the middle of my thighs. I wore an...
loveismyfriend 36-40, F 1 Response 0 Aug 16
Does anyone know if pants with a drawstring canbe tailored?
snowwhitejrm 18-21, M 1 Response 1 Aug 20
I don't normally get all gussied upfor others but I have a huge night coming up in just three days. It's gonna change my life forever. I am not into makeup, frivolous fancy fashions, etc., but I am going all out for this night. My hair's gonna be in its natural Shirley Temple corkscrew curls flooded style. I...
loveismyfriend 36-40, F 0 Sep 26
Well, probably for a guy my age "I lovefashion" is not an appropriate statement; I guess I should correct myself by saying "I am aware of the current fashion trends". Talking of the fashion trends, the NY summer 2015 is full of two-piece outfits for ladies with a very distinct band of exposed skin around the belly...
DearMartian 36-40, M 1 Response 8 Jun 30
I follow fashion - in the springand the fall I go thru all the designer runway shows - I have a love for fabrics details cuts of garments - the work involved in making the product. some are just stunning - really deserve to be on show rather then worn. i also love the spring and the fall editions of the...
blonde10 36-40, F 1 Response 3 Aug 26
I love fashion. It's weirdbut I like when I stick out in a crowd. Most women go out in sneakers and hoodies and I love thigh high boots, well any boots really! My mind was blown when a girl my age had no idea what a wardrobe staple was!!!???!!!?? I just want to take them all under my wing and show them...
KittyKurious 26-30, F 2 Responses 6 Nov 30, 2014
here's something everyone should know about &consider before getting dressed to start the day! http://legstyle.blogspot.com/2015/08/business-as-usual.html
LegStyles 26-30, M 0 Aug 21
I love jean jackets and love how you can wearthem through all seasons. :)
ERMAHGERD1 26-30, F 4 Sep 24
This is my beach look this morning :) What doyou think? Too boring maybe? But it was still cold this morning lol
chloejustchloe 18-21, F 7 Responses 8 Aug 22
Really using my fashion styling to take off mymind of my girl in the army , it kinda works then at times I start to daydream about her when she gets here... This **** is so hard. From sun up to sun down, she's who I think of. Miss her.
urbanshawty 18-21, F 1 Response 1 Sep 1
I love and enjoy gender-bending,or gender-*******, with fashion. I'm talking about going shopping and if I c clothing that I can rock whether it comes from the men's or women's department, I buy it. I believe it adds a sense of individuality and it enhances my masculinity.
cutepapichulo 41-45, M 1 Response 4 Sep 12

subset: commoncrawl


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Release Date:
June 5, 2007
Because she rarely recorded under her own name, a tribute to the late June Carter Cash by default also stands as a tribute to her genealogy: several of the songs among the dozen here were recorded by June with her late husband, Johnny Cash, or by country music's legendary Carter Family, from which June sprang. In addition, the album was produced by John Carter Cash, the only child of Johnny and June, and there are tracks by Carlene Carter, June's daughter from her first marriage (to Carl Smith), and Rosanne Cash, Johnny Cash's daughter with his first wife. As producer, John Carter Cash largely plays it predictable. There are few surprises and no truly offbeat rearrangements or radical interpretations. Folks who enjoyed the singing of June Carter Cash will likely be quite satisfied with these loving, faithful covers. And they should be, because virtually all of the performances are flawless, honest, and inspired. Two duets lead things off: Sheryl Crow and duet king Willie Nelson give a spirited, if somewhat rote, reading to "If I Were a Carpenter," the Tim Hardin-penned classic, and Carlene Carter and Ronnie Dunn hoot it up on "Jackson," the Nancy Sinatra-Lee Hazlewood hit -- both songs were longtime staples of Johnny and June's shows together. A handful of top-shelf country artists, among them Loretta Lynn (a tender "Wildwood Flower"), Brad Paisley (a straightforward, beautifully sung "Keep on the Sunny Side"), and bluegrass hero Ralph Stanley ("Will the Circle Be Unbroken," what else?), pay their respects with kind treatments, and Emmylou Harris, who certainly learned a thing of two from June, sends it off in style with "Song to John," June's self-explanatory tribute of her own. It wouldn't be a tribute album if Elvis Costello didn't turn up, and though his "Ring of Fire" will never go down as the definitive version of that Johnny Cash signature, Costello brings his usual commitment -- and an autoharp, June's favorite instrument -- to his no-frills version. Two of the more left-field approaches come via Patty Loveless and Kris Kristofferson, who bring a touch of drollness to "Far Side Banks of Jordan," and Billy Joe Shaver, who's exactly the right guy to give a bit of bite to the Carter Family's "Kneeling Drunkard's Plea." You've got to think that both June and Johnny would have loved this homage, whose release coincides with the publication of John Carter Cash's same-titled biography of his mother. Jeff Tamarkin, Rovi
- Genre: Country, Rock
- Subgenre: Contemporary Country, Alternative Country
- Category Contemporary Country
- Artist: Various Artists
- Additional Artist: Various artists collection
1.StopIf I Were a Carpenter 3.09
2.StopJackson 3.25
3.StopWildwood Flower 4.4
4.StopFar Side Banks of Jordan 2.51
5.StopKeep on the Sunny Side 4.04
6.StopWings of Angels 3.2
7.StopRing of Fire 3.34
8.StopRoad to Kaintuck 2.44
9.StopBig Yellow Peaches 2.48
10.StopKneeling Drunkard's Plea 3.14
11.StopWill the Circle Be Unbroken 4.31
12.StopSong to John 4
other Info.
- Online Item #: 11588055
- Store Item Number (DPCI): 244-07-0703
- Made in the USA or Imported


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Audi's Crazy Transforming Steering Wheel Has a Jet Fighter Mode, Video Shows How it Works
We have seen the future of steering wheels, and it includes the "Audi James 2025". Touted as a "virtual cockpit of the future," this prototype features an auto-pilot, also known as "jet-fighter mode", is activated, the steering wheel, seating position and light coding system automatically change. The display shows the car's planned driving maneuvers while a secondary screen provides access to infotainment functions. Continue reading for the video and more information.


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News & Events
Holly Hughes Featured in "Come as You Are" UMMA Symposium
October 2, 2015
Holly Hughes will be a featured speaker at an October 24 symposium organized by the U-M History of Art department and UMMA in conjunction with the upcoming show Come As You Are: Art of the 1990s.
Come As You Are: Art of the Nineties opens on October 17.
Come as You Are: Art of the 1990s, the first major museum survey to examine the art of this pivotal decade in its historical context, showcases over 64 works by 46 artists born or practicing in the United States. The exhibition, whose title references the 1992 Nirvana song (considered by many an anthem for the decade), focuses on three principal themes—debates over "identity politics," the digital revolution, and globalization—and explores a range of geopolitical milestones and social issues through the perspective of artists working at that time. The exhibition also illustrates the diverse ways in which the developments of the 1990s redefined contemporary approaches to artistic practice and, in the words of exhibition curator Alexandra Schwartz, "writes a history of the '90s through the lens of the visual arts."
Come as You Are looks at the dramatic changes in the art world itself, including the ongoing culture wars; issues of artistic freedom and censorship; the impact of new media and the emergence of video, sound, and digital art; the expansion of the global art market; and the explosion of art fairs and biennials. It also investigates the art world's increasing heterogeneity as artists of color, women artists, and LGBT artists attained increased prominence. Artists include Doug Aitken, Felix Gonzalez-Torres, Glenn Ligon, Julie Mehretu, Prema Murthy, Shirin Neshat, Catherine Opie, Gabriel Orozco, Diana Thater, Rirkrit Tiravanija, and Kara Walker in a wide range of works including installations, paintings, sculptures, drawings, prints, photography, video, and digital art.
Come as You Are: Art of the 1990s UMMA
Endi Poskovic and Amanda Lilleston Participate in 8th International Print Triennial
October 1, 2015
Work by Stamps Professor Endi Poskovic and alumna Amanda Lilleston (MFA 2012) is featured in the 8th International Print Triennial, "Color in Graphic Art - Duets", in Toruń, Poland. The exhibition, open through October 31, 2015, features work by young artists, showing new paths for the development of the discipline.
...we would usually invite recognized, prominent artists from all over the world – a mode of conduct appropriate for an event with named invitations. In 2015 we wish to break with the tradition. Still, the curator did send invites to renowned figures in graphics worldwide, but this time supplemented with a kind request to "extend the guest list" with one's younger colleagues – artists. Herein lies the link between the Triennial and two of the core profile features of Wozownia, i.e. promotion and experimentation.
8th International Graphic Triennial "Color in Graphic Art" – Duets
Rebekah Modrak: Consumption Markets & Culture
September 29, 2015
This week in academic publishing, Laurie A. Meamber, Associate Professor of Marketing at George Mason University provided commentary on Stamps Associate Professor Rebekah Modrak's paper Learning to talk like an urban woodsman: an artistic intervention for Consumption Markets & Culture, a peer-reviewed journal published by Routledge. Rebekah's paper is an artist statement on her 2013 Re Made project, which presents a clever parody of "brand culture." Visit the Re Made Company online.
Commentary on learning to talk like an (urban) woodsman: an artistic intervention | Laurie A. Meamber
Alumni Spotlight: Catherine Meier
September 29, 2015
Stamps alum Catherine Meier (MFA 2009) explores the meaning of "open space" through animation, site-specific installations, and large-scale prints and drawings. Representing a state of mind as well as a state of being, these expansive works are redolent of the artist's own travels crossing the Great Plains of North America and the Mongolian Steppe. Recently, Meier was an Artist in Residence at Badlands National Park in South Dakota, and her awards include a national Jacob K. Javits Fellowship for Graduate study, three Arrowhead Regional Arts Council Fellowships, and a McKnight Visual Artist Fellowship. Viewers can catch a glimpse of Meier's work on view at a variety of venues this fall.
On view through November 29, 2015: This Big Land: Catherine Meier at The Museum of Nebraska Art
October 15-November 19: Standing Witness, site: Sage Creek, supported by the Minnesota Artist Exhibition Program at the Minneapolis Institute of Art. As part of Catherine's 13/14 McKnight Fellowship, Catherine also made a Limited Edition art book entitled site: Sage Creek.
November 5-January 3, 2016: American Art: It's Complicated, a group exhibition at the Minnesota Museum of American Art.
Matthew Zivich: "Americana" Mott Community College
September 28, 2015
Work from Matthew Zivich's (B.S. in Design, 1960) "Americana Series" (2007 - 2015) is featured in a solo exhibition of paintings and collage on display at at Mott Community College Visual Arts and Design Center, Room 128 gallery. Zivich, a Professor of Art at Saginaw Valley State University, was invited to show his work by the art faculty of Mott Community College.
Exhibition Dates: September 28 - October 13, 2015
Public gallery talk: October 7, 2015 at 1:00 pm
Mott Community College
1401 East Court Street, Flint, MI 48503
Gallery hours: M-F, 9:00 am - 4:30 pm
Endi Poskovic Exhibits, Lectures at IMPACT 2015 Conference in Hangzhou
September 28, 2015
Stamps Professor Endi Poskovic's work is featured in Resurrecting the Phantom: Print in the Post-Print Biennial at CAA Art Museum in Hangzhou, the main exhibition of the 2015 IMPACT International Printmaking Conference at China Art Academy. Organized by Xu Jiang and Kong Guoqiao, and curated by Cai Feng, Li Zhenhua, and Min Han, Resurrecting the Phantom includes work by Xu Bing, Stephen Chambers, Chen Haiyan, Chen Qi, Marian Crawford, Kiki Smith, Kang Jianfei, Klaus Merkel, Kong Guoqiao, Endi Poskovic, Qiu Zhijie, Kavita Sha, Su Xining, Clare Humphries, Dick Jewell, Sun Xun, Tang Ping, and Wu Junjong.
At IMPACT 2015, Poskovic also presented the paper Landscape, Abstraction, and Contemporary Print and chaired a panel on Social Practice in Contemporary Print with Marian Crawford, Clare Humphries, and artists from East London Printmakers.
Hosted by China Academy of Art in Hangzhou, the IMPACT biannual conference is the largest international academic and research forum in the field of printmedia, which brings artists, designers, educators, and curators from across the world.
Jill Stefani Wagner Named Master Pastelist by the Pastel Society of America
September 28, 2015
On Sunday, September 20, the Pastel Society of America (PSA) named Jill Stefani Wagner (BFA 1978) one of the Society's Master Pastelists.
After her painting (below) won the Pastel Society of Canada Cash Award at the PSA's Enduring Brilliance exhibition in New York (her third cumulative award in competitions), Wagner qualified for the Master Pastelist honor.
The PSA, based in New York City, is the oldest pastel society in the United States.
Jules Pieri Featured in Inc. Magazine
September 28, 2015
Jules Pieri (BFA '82), founder and CEO of The Grommet, recently spoke with Inc. Magazine editor-at-large Leigh Buchanan about how working for Hewlett-Packard CEO Meg Whitman shaped her career and leadership philosophies.
"Having Meg land on my head as my boss didn't feel lucky at first because she is kind of tough," says Pieri of the current Hewlett-Packard and former Ebay CEO. Soon, though, she embraced Whitman as a mentor. "My career plan was, 'Work for Meg,' because she was so great to work for," says Pieri, who shares some of the wisdom she picked up from Whitman.
5 Leadership Lessons I Learned Working for Meg Whitman | Inc.com
Holly Hughes Featured on The Moth Podcast
September 23, 2015
Recorded at a Moth StorySLAM in 2013, Stamps professor and NEA4 member Holly Hughes is featured on this week's edition of The Moth Podcast with a story about fighting back when her NEA grant was vetoed by the US Congress in 1990. Listen to her story, The Difficult Truth of Art.
Endi Poskovic Exhibits in 2015 Krakow International Triennial
September 22, 2015
Stamps Professor Endi Poskovic is featured in Behind the Curtain, an exhibition at the 2015 Krakow International Triennial on view through October 30 at the International Centre for Graphic Arts.
Behind the Curtain gathers works by artists who worked at the jury panel that designed the Main Exhibition of MTG – Krakow 2015, as well as the exhibition of the Grand Prix of Young Polish Print – Krakow 2015, those who offered the Society their advice and support by working with the International Experts Council, as well as those who as members of the Executive Board of the Society actively promote Polish and international printmaking both in Krakow and all around the world.
The exhibition showcases a diversity of creative and aesthetic approaches, whose richness contributes to the multiplicity of initiatives undertaken by the Krakow International Print Society and the International Centre for Graphic Arts in Krakow.
International Centre for Graphic Arts - Centrum Gallery
Rynek Główny 29, 2nd floor, 31-010 Krakow, Poland
September 18 - October 30, 2015
Professor Poskovic also participates in the international symposium the International Centre for Graphic Arts in Krakow and hosted by Jan Matejko Academy of Fine Arts in Krakow.
Behind the Curtain. Exhibition of prints of jurors and artists – members of the Board of SMTG


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Econo Inn
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Day in Anchorage
... or orphaned. Three very cute baby black bears were playing (their mother had been hunted and killed illegally).
A great Zoo to visit.
After the zoo, we all decided to head off to the Alaskan Native Heritage Centre.
Very interesting and informative about native ...
My Brightest Impressions about New Zealand
... for a good reason. Smooth waves shaped in this
coastland make surfing exciting and thrilling. Even if you are a starter, you
will be taught how to ride waves and gain confidence standing up on a
Travelling through
New Zealand, you understand that there are not only breath-taking landscapes
you can admire. This is the country where you can feel the beauty in different ways,
and there will be a discovery at every turn.
Day 2 - The big Sleep
... glacier feed river. It had a rely good service the people where rely nice. I was seated in a rely nice area. the food tock about 10 mins to come out and it was rely enjoyable.
The day felt like it went for ever as the days get longer in the summer months. A I walked back to the hostel I meat up with a few people that come from New Zealand. They had been living there for a few years and gave me some more ideas and witch guide to go ...
Where the Pacific comes to the Heart of Alaska
... it was fun watching them take off and land.
We hurried back to camp for a travel meeting for tomorrows trip to Homer but opted out of the scheduled activities for the evening to find a sushi restaurant, try to chase the tidal bore and grocery shop.
It would have been nice to spend a few more days in Anchorage. Maybe someday we can come back.
Homer, AK and a halibut fishing trip is our next adventure
Exploring Alaska in a 20-foot Winnebago camper
... lose the direction, and can only find a Mercantile area. It turns out to be the same thing, so we wait in line while a big group is served, then present our paperwork, which is found suitable, and we are given a permit for a "B" site, anywhere in the Riley Creek campground, starting a hundred metres away. Camping is A$24 per night, National Park entry fee is A$11 each and our day trip tomorrow on the Wonder Lake Shuttle Bus is A$51 each). Dianne wants to check out ...


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Chocolate cravings are more likely to be cultural than biological. While American women tend to crave chocolate, Egyptian women crave savory treats, like a soup made with greens or stuffed grape leaves, says cravings researcher Debra Zellner, Ph.D., of Montclair State University in New Jersey.
Does Your Body Need Chocolate?
Chocolate cravings are more likely to be cultural than biological.
Meet the Four Badass Women Rowing 24 Hours a Day to Australia Right Now
This is a record-breaking row.
18 Ways Your Phone Is Ruining Your Health
Your device is more destructive than you think.
Why You *Shouldn't* Do a Breast Self Exam
Breast Cancer Awareness month has everyone buzzing about preventative healthcare—but according to the experts, this is a step you should...
More From Health & Fitness


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Economy - Most Recent
Paulson wants wider bailout
Nov 4, 2008
The Treasury wants to extend the bailout beyond banks, because it's a way of injecting capital into the economy quickly. But Washington Bureau Chief John Dimsdale reports that not everyone likes the idea.
Early voting is good for business
Nov 4, 2008
Scores of voters are lining up across the country to cast ballots, but in some states voters have already had the opportunity to get it out of the way. Janice Baker reports why the move can also be good for stores.
The growing market for political futures
Nov 3, 2008
Forget the Gallup Poll and the shouting heads on MSNBC and Fox. Go to InTrade.com, a so-called "prediction market" with a record of calling races. Kai Ryssdal asks two political experts about gambling on politics.
Credit card crisis on the horizon
Nov 3, 2008
Next up in financial crisis headlines: credit cards. Delinquencies on card payments are on the rise and consumers are cutting back on credit card use. Neither is good for credit card companies. Rachel Dornhelm reports
More and more banks want in on bailout
Nov 3, 2008
If the bailout made some banks uneasy at first, they got over it. Thousands of banks are lining up for the funds now. Steve Henn reports the idea of using the money to buy other banks is a motivator.
Late stock swings and some credit melt
Oct 31, 2008
While there's been good news in the credit market, stocks are another story and that story is late-day volatility. To talk about both, Kai Ryssdal calls on Diana Henriques of the New York Times and trader Andy Brooks.
There's such a thing as a smart deficit
Oct 31, 2008
Whoever is elected president will not have an enviable job. The economy is in crisis and the defict is sky high. But commentator Thomas Frank says deficits can be good depending on how the money is spent.
Lend, don't spend bailout, Frank insists
Oct 31, 2008
Rep. Barney Frank insists banks that receive any of the $700 billion in bailout money use it for lending, not for bonuses or to take over other banks. Washington Bureau Chief John Dimsdale looks into the rules.
Fed's new role must not be permanent
Oct 29, 2008
An important point to keep in mind, says commentator David Frum, is that the government's new role in banking, insurance and other industries is for emergency purposes. Ultimately, that role needs to go away.
Will latest rate cut help the economy?
Oct 29, 2008
The Federal Reserve cut the interest rate to 1% in an effort to encourage lending and stimulate the economy. Will it work? What about inflation? Washington Bureau Chief John Dimsdale reports.


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Villa Cimmino Hotel Restaurant
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Bari to Napoli (Naples) then Castellamare de Stabi
... only 1 man got on so I think maybe the words were about the number of cases he had. Got from the bus to the train station, and then the Circumvesuniana line. Train to Castellamare de Stabia station. Oh how I hate steps. I so regret bringing a suitcase and not my backpack. It took about half an hour on the train to get out here. Interesting ride. There is just high rise flats the whole way, mostly quite dingy looking. ...
On the boat to Greece !!!!!!
... they come back to the Novotel. Very relaxing in my room on the boat...called Catania....Grimaldi Lines....look it up. Basically, because breakfast is from 8.30am til 10am....and we don't get off the boat till after lunch...so lots of time to pack etc and a bit of a sleep in. And I just remembered a packet of peanut M&Ms in my bag. Life doesn't get much better than this. Xxx Sometime later...you actually can eat too many ...
Day Eleven - The Biggest Ice Cream in the World
... the largest ice cream in the world! I'm serious - the cone was of a normal size but they piled so much ice cream on the top it took a good twenty minutes to eat it (including finding some shade to stop it from melting too quickly). It was gorgeous. I visited the Amalfi naval history museum after that. If I say that the best part of it was the free toilet, that probably tells you all you need to know. Next came Ravello, a one ...
Amalfi Coast
... to Stabia, walked up the hill, and went back to relax mode. We were adamant that we were going to buy a pizza, along with salami and cheese for dinner, but when we got to our pizzeria, we found that next door was closed. We nearly wept! So we ordered pizza, some chicken-flavour potato thing (which were fatteningly awesome), bought some beer on the way back to our hotel, and sat on our balcony to enjoy dinner. Not quite the day we started out to complete, but still a good ...
Isle of Capri & Sorrento
As a day tour, we decided to go on a cruise around the Isle of Capri which is a small Island off Sorrento. Sailing around the island, you can see a lot of large houses belonging to the rich and famous. They say that it's only during the months of July and August the island is touristy, other times it is more quiet and relaxed.
One of the main attractions on the Island is a number ...


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All materials on Kansas Memory are made available for noncommercial educational and research purposes only. It is the patron's responsibility to request and obtain permission from both the image and copyright owner(s) to use materials.
To obtain permission or to purchase a reproduction, please contact the KSHS Reference Desk at 785-272-8681, ext. 117 or firstname.lastname@example.com. See the Copyright and Permission FAQ for more information.
A letter from W.B. Shirley to Kansas Governor St. John inviting him to speak at a temperance picnic to be held in Buffalo, Wilson County, on October 14.
Creator: Shirley, W. B.
Date: September 18, 1880
Item Number: 307791
Call Number: Governor's Office, St. John, Correspondence Received-Subject File, Box 20
KSHS Identifier: DaRT ID: 307791
Collections - State Archives - Governor's Records - St. John, John P.
Date - 1880s - 1880
Government and Politics - Reform and Protest - Prohibition and temperance
Government and Politics - State Government - Governors - St. John, John Pierce
Objects and Artifacts - Communication Artifacts - Documentary Artifact - Correspondence
Objects and Artifacts - Communication Artifacts - Documentary Artifact - Letter
Objects and Artifacts - Communication Artifacts - Documentary Artifact - Record, Government
People - Notable Kansans - St. John, John Pierce, 1833-1916
Places - Cities and towns - Chanute
Places - Counties - Neosho
Thematic Time Period - Age of Reform, 1880 - 1917
Type of Material - Unpublished documents - Government records - Correspondence
Type of Material - Unpublished documents - Letters


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