text:
In West Africa the first stage in the import trade, that is, direct importing, is largely in non-African hands. From information extracted by the Department of Statistics in Nigeria from customs records it appears that in 1949 about 85% of the import trade of that country was handled by European firms, about 10% by Levantine and Indian firms, and about 5% by African firms. Since then the African share has probably increased slightly, partly as a result of preferential treatment in the allocation of import licences in the commodities affected by specific licensing.
The information available for the Gold Coast is less comprehensive than for Nigeria, but as will be suggested subsequently in this chapter it is sufficient to show that the general pattern of the participation of different groups in the import trade is similar to that in Nigeria. The share of African traders is probably somewhat larger as a result of more marked discrimination in their favour in the administration of import licensing. But as in recent years (especially in 1949 and 1950) specific licensing covered only a comparatively small part of all imports it did not affect the general picture greatly. It is probable that if the statistics for the Gold Coast were available in the same detail as for Nigeria they would show a somewhat larger proportion of importing in Indian and Levantine hands.
Africans frequently maintain that their small participation in direct importing proves that the import trade is in the nature of a monopoly. This is misleading, since a trade can be highly competitive even if all the traders are members of the same expatriate community. In the West African import trade there is in fact a substantial measure of concentration,1 a large share of the trade being handled by a small number of firms. In view of the political and social importance of this question it seems Worth while to investigate the degree of concentration____________________

subset: commoncrawl


text:
|Numéro de publication
|Type de publication
|Numéro de demande
|Numéro PCT
|Date de publication
|15 juil. 2003
|Date de dépôt
|24 aoűt 2000
|Date de priorité
|27 aoűt 1999
|État de paiement des frais
|Autre référence de publication
|Numéro de publication
|Isao Saito, Kenzo Fujimoto, Shigeo Matsuda
|Cessionnaire d'origine
|Japan Science And Technology Corporation
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Citations de brevets (4), Citations hors brevets (5), Référencé par (24), Classifications (8), Événements juridiques (4)
|Liens externes: USPTO, Cession USPTO, Espacenet
1. Field of the Invention
The present invention relates to reversible photoligating nucleic acids and phosphoramidites. More specifically, the present invention relates to a novel reversible photoligating nucleic acid which can be useful in its application to antisense DNA, antigene DNA, photogenetic diagnostic therapy, and in the analysis of DNA-protein interaction and the like, and can be used to control the formation and specific cleavage of ligation structures in biofunctional molecules using light; the present invention also relates to phosphoramidites useful for the synthesis of such nucleic acids, as well as methods of photoligation and photocleavage wherein such nucleic acids are used.
2. Description of the Related Art
It has been known that controlling the ligation and local cleavage between DNAs, RNAs, PNAs and proteins is important in determining biofunctions and the mechanism of bioactivities, as well as in creating bioactive substances.
For example, controlling the formation and the cleavage of the ligation structures of DNA-DNA, DNA-RNA, DNA-PNA or DNA-protein is very important in elucidating antisense DNAs, antigene DNAs, and genetic diagnostic therapy, and in determining the interactions between DNA-protein, as well as in controlling the structure of biomolecules accordingly.
Therefore, many means for ligation and cleavage have been studied, and methods involving photoirradiation are being investigated, as well.
However, the methods reported so far have problems such as the lowness of ligation product yield of about 40%, and the generation of various by-products. Further, examples of methods wherein the ligated sites are specifically cleaved have not been known.
Accordingly, the object of the present invention is to provide solutions to the above-described problems of the conventional methods, and to provide a novel technical means that gives selective high ligation product yield and selective photocleavage of the ligated site, and enables the free and reversible control of photoligation and photocleavage.
The present invention provides, as a means to solve the aforesaid problems, firstly, a reversible photoligating nucleic acid represented by the following formula (1):
Also, secondly, a phosphoroamidite represented by the following formula (2):
is provided.
Further, the present invention provides, thirdly, a method of photoligation, wherein a system containing the above reversible photoligation nucleic acid and a biofunctional polymer is irradiated to form a ligation structure. Fourthly, a method of photocleavage, wherein the ligated structure formed between a reversible photoligating nucleic acid and a biofunctional polymer is cleaved by the irradiation of light with short wavelength is provided.
By irradiating the above-described reversible photoligating nucleic acid of the present invention, i.e. a DNA containing photoligating nucleoside, 1) the ligation and cleavage of DNA-DNA, DNA-RNA, DNA-PNA and DNA-protein is enabled, and uses in a) antisense DNA, b) antigene DNA, c) photogenetic diagnostic therapy, and d) analysis of DNA-protein interaction may be developed.
Furthermore, according to the present invention, high ligation products yield of 95% or higher is obtained, and the ligated site-specific cleavage by irradiation is also enabled.
FIG. 1 shows an absorption spectrum exemplifying reversible photoligation and photocleavage reaction. The nucleic acid sequences, 5′-CACGCGAGCACA-3′, 5′-TGTGCT-3′, 5′-vCGCGTG-3′, set forth in the Figure correspond to SEQ ID Nos: 1, 2 and 3, respectively, of the Sequence Listing.
The present invention comprises the characteristics described above; the best mode for carrying out the invention is described below.
The reversible photoligating nucleic acid of the above-described formula (1), i.e. a DNA containing photoligating nucleoside, of the present invention, has a characteristic structure comprising a vinyl group at the 5-position of the pyrimidinering. The presence of the vinyl group in the structure makes the control of ligation or cleavage with its pairing biofunctional polymer such as DNA, RNA, PNA or protein using light possible. The reversible photoligating nucleic acid may also be referred to as a vinylcytosine-containing functional nucleic acid. The reversible photoligating nucleic acid may also comprise other acceptable substituents in the pyrimidine ring and the nucleoside region; further, the amino group (NH2) and the hydroxyl group (OH) may be protected by any permissible protecting group. The present invention also encompasses derivatives of the nucleic acid.
The photoligating nucleic acid of the present invention, represented by the above-described formula (1), may be easily synthesized by, for example, the following route, via a phosphoramidite represented by the above-described formula (2).
In step 1, for example, to a 5-vinyldeoxyuridine DMTr, a phosphitylating reagent is reacted to form a vinylcytosineamidite precursor, which is then reacted with 1, 2,4-triazol. In this case, examples of phosphitylating reagents include the following:
Further, in step 2, DNA oligomers may be synthesized by a solid phase synthesis in a DNA synthesizer.
Photoligation is enabled by photoirradiation under the presence of biofunctional polymers such as DNA, RNA, PNA or protein, to which the nucleic acid is ligated. On the other hand, a photocleavage may be performed as a ligated site-specific cleavage, by irradiating light with shorter wavelength. For example, photoligation may be performed by photoexcitation at a wavelength longer than 330 nm, while photocleavage may be performed by photoexcitation at a wavelength shorter than 320 nm.
The method of photoirradiation, may be chosen from various means, an example being the use of a trans-illuminator.
The present invention is described in more detail through the following examples. However, the examples are merely illustrative in nature and serve as representative examples of the preferred embodiments. Other examples within the scope of the claims are also possible. Thus, the following examples should not be construed to narrow the spirit and scope of the claims.
As a reversible photoreactive nucleic acid of the present invention, a functional nucleic acid containing vinylcytosine was synthesized, following steps 1 and 2 of the above-described reaction scheme.
(a) Step 1
To a solution of 5-vinyldeoxyuridine DMTr (166 mg, 0.298 mmol) in CH3CN, 2.0 ml of a solution of a phosphitylating reagent (98.0 μL, 0.309 mmol) and 0.5 M tetrazol in CH3CN (2.0 mL) was added. The reaction mixture was stirred for 1.0 hour, then extracted, after which the organic phase was dried and boiled with CH3CN to give a vinylcytosineamidite precursor (228 mg). Next, to a CH3CN solution of phosphorus trichloride (0.32 g, 2.10 mmol) and 1,2,4-triazol (0.667 g, 9.676 mmol), the vinylcytosineamidite precursor was added in three parts at 0° C. and stirred for 3 hours. Then, extraction was performed; the organic phase obtained was dried and boiled with CH3CN to give 95.7 mg (0.118 mmol) of vinylcytosineamidite at a yield of 75%.
1HNMR (400 MHz, CDCl3) d 2.21 (ddd, J=12.1 Hz, J=7.4 Hz, J=6.3 Hz, 1H, H-2′b), 2.35 (ddd, J=12.1 Hz, J=6.1 Hz, J=3.1 Hz, 1H, H-2′a), 2.95 (dd, J=10.6 Hz, J=3.4 Hz, 1H, H-5′), 3.38 (dd, J=10.6 Hz, J=3.4 Hz, 1H, H-5′), 3.71 (s, 6H, OCH3×2), 3.90-3.99 (m, 1H, H-4′), 4.45-4.48 (m, 3H, H-3′), 4.86(dd,J=10.2 Hz, 2.0 Hz, 1H, vinyl trans), 5.60-5.73(m, 1H, vinyl cis. H-1′), 6.29 (dd, J=7.4 Hz, J=6.1 Hz, 1H, H-1′), 6.73-6.77(m, 4H, H-b to OCH3×4), 7.17-7.28 (m, 9H, phenyl), 7.29-7.32(m, 1H, CH=CH2), 7.58(s, 1H, H-6), 8.23 (bs, 1H, NH). 31PNMR (CDCl3, 85% - H3PO4 in D2O ext. 0 ppm) d 149.811 & 150.386 (diastereomer of the products).
(b) Step 2
The CH3CN solution of vinylcytosine amidite (0.1 M, 3 mL) obtained in step 1 was subjected to an automated DNA synthesizer, and DNA oligomers were synthesized according to conventional solid phase synthesis methods, excised, deprotected and purified by high-performance liquid chromatography.
The compound obtained was identified by molecular weight determination through an ESI-TOF method.
The target oligomer (5′-TGTGCT-3′(SEQ ID No: 2), 20 mM) was mixed with a vinylcytosine-containing oligomer (5′-VCGCGTG-3′(SEQ ID No: 3), 20 mM) in the presence of a template oligomer (5′-CACGCGAGCACA-3′(SEQ ID No: 1), 25 mM), and irradiated in 500 mM of cacodylic acid buffer (50 mM, pH7.0) at 366 nm using a transilluminator. Photoligation of the oligomers occurred with a yield of 90% or higher (FIGS. 1a) and b)).
Next, the solution was irradiated at 302 nm using a transilluminator. The oligomer was successfully photocleaved almost quantitatively (see FIGS. 1b) and c)).
The molecular weight of 5′-VCGCGTG-3′(SEQ ID No:3) was determined by ESI-TOFF. Results are shown in the following Table 2.
ESI-TOFF mass calcd. for C80H75N23O35P5(M-H), 1832.36; found, 1832.34
As described in detail above, the present invention provides a novel technique, which enables high ligation product yield, specific photocleavage of ligated-sites, and free and reversible control of photoligation and photocleavage.
|Brevet cité
|Date de dépôt
|Date de publication
|22 sept. 1997
|16 juin 1998
|Mta Zozponti Kemiai Kutato Intezet
|Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and 5-(1-alkynl) pyrimidines
|12 janv. 1989
|29 mars 1995
|Amoco Corporation
|Template-directed photoligation
|Titre non disponible
|21 janv. 1994
|4 aoűt 1994
|Mta Koesponti Kemiai Kutato In
|Oligodeoxynucleotides containing 5-alkyl-, 5-(1-alkenyl)- and 5-(1-alkynyl)pyrimidines and pharmaceutical compositions containing such compounds
|Fujimoto Kenzo et al., "Template-Directed Photoreversible Ligation of Deoxyoligonucleotides via 5-Vinyldeoxyuridine", J. Am. Chem. Soc., vol. 122, No. 23, Jun. 14, 2000, pp. 5646-5647.
|S. G. Rahim et al., "Synthesis and Biological Properties of 2'-deoxy-5-vinyluridine and 2'-deoxy-5-vinylcytidine", Nucleic Acids Research, vol. 10, No. 17, 1982, pp. 5285-5295.
|S. G. Rahim et al., "Synthesis and Biological Properties of 2′-deoxy-5-vinyluridine and 2′-deoxy-5-vinylcytidine", Nucleic Acids Research, vol. 10, No. 17, 1982, pp. 5285-5295.
|S. G. Rahim et al., Synthesis and biological properties of 2′-deoxy-5-vinyluridine and 2′deoxy-5-vinylcytidine, Nucleic Acids Research, vol. 10, No. 17, 1987, pp. 5285-5295.*
|S. G. Rahim et al., Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine, Nucleic Acids Research, vol. 10, No. 17, 1987, pp. 5285-5295.*
|Brevet citant
|Date de dépôt
|Date de publication
|14 mars 2003
|19 aoűt 2008
|Nuevolution A/S
|Method for synthesising templated molecules
|22 mars 2005
|27 avr. 2010
|Nuevolution A/S
|Ligational encoding using building block oligonucleotides
|20 juin 2002
|1 juin 2010
|Nuevolution A/S
|Templated molecules and methods for using such molecules
|17 nov. 2006
|14 déc. 2010
|Japan Science And Technology Agency
|Method for detecting target nucleic acid with specific base sequence and set of nucleic acids for detection
|22 mars 2004
|29 mars 2011
|Nuevolution A/S
|Ligational encoding of small molecules
|16 avr. 2009
|5 juil. 2011
|Japan Advanced Institute Of Science And Technology
|Sequence-specific nucleic acid purification method manner
|30 oct. 2003
|26 juin 2012
|Nuevolution A/S
|Method for the synthesis of a bifunctional complex
|13 avr. 2006
|13 mai 2014
|Nuevolution A/S
|Method for selecting a chemical entity from a tagged library
|24 juil. 2008
|19 aoűt 2014
|Neuvolution A/S
|Method for synthesising templated molecules
|9 déc. 2008
|13 janv. 2015
|Nuevolution A/S
|Templated molecules and methods for using such molecules
|8 juil. 2011
|4 aoűt 2015
|Nuevolution A/S
|Method for producing second-generation library
|25 avr. 2012
|18 aoűt 2015
|Nuevolution A/S
|Method for the synthesis of a bifunctional complex
|19 déc. 2003
|1 sept. 2015
|Nuevolution A/S
|Quasirandom structure and function guided synthesis methods
|10 déc. 2002
|31 mars 2005
|Siegfried Bagusche
|Roll-hardening device in a roll-hardening machine for crankshafts
|14 mars 2003
|11 aoűt 2005
|Gouliaev Alex H.
|Building block capable of functional entity transfer to nucleophil
|14 mars 2003
|6 oct. 2005
|Henrik Pedersen
|Method for synthesising templated molecules
|14 mars 2003
|6 oct. 2005
|Gouliaev Alex H
|Building block forming a c-c bond upon reaction
|14 mars 2003
|10 nov. 2005
|Nuevolution A/S
|Building block forming a c-c or a c-hetero atom bond uponreaction
|30 oct. 2003
|11 mai 2006
|Nuevolution A/S
|Method for the synthesis of a bifunctional complex
|30 juil. 2003
|8 juin 2006
|Henrik Pedersen
|Multi-step synthesis of templated molecules
|22 mars 2004
|2 nov. 2006
|Nuevolution A/S
|Ligational encoding of small molecules
|23 févr. 2004
|30 nov. 2006
|Nuevolution A/S
|Method for obtaining structural information about an encoded molecule
|13 avr. 2006
|28 déc. 2006
|Gouliaev Alex H
|Method for selecting a chemical entity from a tagged library
|23 févr. 2004
|1 févr. 2007
|Nuevolution A/S
|Method for producing second-generation library
|Classification aux États-Unis
|435/6.12, 536/23.1
|Classification internationale
|Classification coopérative
|Classification européenne
|28 juin 2001
|11 janv. 2007
|Fee payment
Year of fee payment: 4
|7 janv. 2011
|Fee payment
Year of fee payment: 8
|6 janv. 2015
|Fee payment
Year of fee payment: 12


text:
Sims 3 Support by Cedega
The Wine-based commercial software Cedega offers with its new 7.3 release support for the latest version of Sims.
This doesn't happen often in Linux. Part 3 of Sims has only just been released and thanks to Cedega it can be played already. Usually it takes a while before popular games can be played on a free platform. Among the numerous top games Linux gamers are still waiting for is Unreal Tournament 3, the action game that officially appeared towards the end of 2007.
Now here's the catch. Game fans will not only have to pay for the game, they'll also need a subscription with Cedega and a Nvidia FX card, which according to Cedega is the only one to run problem free. For ATI cards with proprietary drivers the software company is making no promises and other drivers get support solely from the Cedega community.
Along with the support for Sims, Cedega 7.3 comes with various bugfixes and has solved problems with the keys for City of Heroes and unwanted advertising banners in Command and Conquer: Red Alert 3. Its also a little faster. The software uses a modified Wine to get the Windows games to run on Linux. At the moment, the new Cedega can be tested on the SPORE Creature Creator.
Issue 180/2015
Buy this issue as a PDF
Dyreza Malware is Back
Powerful man-in-the-middle attack is now targeting online shopping.
Kernel Developer Matthew Garrett Forks the Linux Kernel
Another high-profile coder says the kernel team needs a kinder, gentler culture.
Bugzilla Bug
Bug database has a bug of its own that could allow an intruder to create an unauthorized account.
US Launches New Strategy for Broadband Access
Report focuses federal resources on achieving universal Internet access.
RC4 Finally Gets the Fork
Leading browser makers say "no" to porous encryption algorithm
IBM Says TOR Network a Vehicle for Ransomware
Report from the X-Force group says attackers are using TOR to hide their crimes
Mozilla Announces new Firefox API
Future Firefox extensions will be compatible with Chrome.
Weird Security Flaw Affected Intel Chips for 16 Years
Better read this if you bought your computer before 2011
OpenSSH 7.0 Secure Shell Arrives
Users should upgrade to the new version as soon as possible
Qemu Flaw Lets the Guest Escape
Xen project announces a privilege escalation problem for Qemu host systems


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May 1, 2013
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RIO DE JANEIRO — The most entertaining World Cup in a generation comes down to a final match that pits the planet's best player against the tournament's best team.
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It is this collaborative process in research and product development together with venture funding that allows OmegaGenesis to greatly advance the treatment of primary diseases potentially affecting hundreds of millions globally.
OmegaGenesis through its collaboration with Mayo Clinic has retained exclusive license to further test Angiogenesis characteristics of these nano rods and develop products. The agreement includes existing intellectual property and a commitment to ongoing collaborative research projects in early-development stages at Mayo Clinic.
In addition to licensing technology and patents to OmegaGenesis, Mayo Clinic and OmegaGenesis scientists will cooperate in conducting lab tests.
About OmegaGenesis
OmegaGenesis, Inc. is a venture funded bio-technology company based in Gilroy, California and Rochester, Minnesota. OmegaGenesis was founded in 2008 to bring Mayo Clinic core research and resulting products to market based on the idea that controlling blood vessel growth would improve human body management for a diverse set of medical applications ranging from cancer and malignancies treatments to common wound healing and tissue reactivation.
The Company was founded to discover and produce suitable nano-materials to manage human body functions at a nano scale -- the cell and sub-cell level -- accelerating cellular-based biologic therapies to control blood vessel growth. These nano-materials will enable doctors to treat disease at sub-cell level in a non-intrusive manner instead of treating the disease at the organ or tissue level.
Our mission emphasizes collaborative research in partnership with leading medical centers, rapid product design, development, and validation. OmegaGenesis collaborates with strategic academic and corpor
|SOURCE OmegaGenesis
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000 ABPZ20 KNHC 040517 TWOEP TROPICAL WEATHER OUTLOOK NWS NATIONAL HURRICANE CENTER MIAMI FL 1100 PM PDT SAT OCT 3 2015 For the eastern North Pacific...east of 140 degrees west longitude: A broad and elongated area of low pressure located about 1050 miles southwest of the southern tip of the Baja California peninsula is producing disorganized showers and thunderstorms. While some gradual development is possible, environmental conditions are expected to become less favorable during the next few days while this system moves northeastward at about 5 mph. * Formation chance through 48 hours...low...30 percent * Formation chance through 5 days...medium...40 percent The remnants of Marty, located about 175 miles west-southwest of Cabo Corrientes, Mexico, are producing a large area of disorganized showers and thunderstorms. Strong upper-level winds are expected to prevent significant development of this system while it moves north-northeastward at 15 mph toward the coast of southwestern Mexico during the next day or so. Regardless of development, heavy rainfall is possible over portions of southwestern Mexico during the next couple of days. * Formation chance through 48 hours...low...20 percent * Formation chance through 5 days...low...20 percent $$ Forecaster Brown
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Daemen College : Offices & Services : Global Programs Office : International Students : How do I apply for a Canadian Tourist Visa?
If you are currently enrolled at Daemen College and would like to apply for a Canadian tourist visa, please do the following:
NOTE: If you are currently in the United States, you must submit your application via the United States Postal Service (USPS). Please follow all instructions on the webpage.
The Western New York Service Learning Coalition, located on Daemen's campus serves as a conduit for community organizations seeking service-learning students.
Graphic Design
Nick held several student leadership positions at Daemen and also completed an internship for graphic design. He recently traveled abroad to Italy with students and the department chair of the program.
©2014 Daemen College : 4380 Main Street, Amherst, NY 14226 : 800.462.7652


text:
August 27, 2012
The price of oil fell Monday, Aug. 27, 2012, as the threat to production from Tropical Storm Isaac appeared to lessen and traders speculated about a release of oil from U.S. reserves.
Stories this photo appears in:
Gas prices rise as refineries shut for Isaac
The U.S. government says 78 percent of the oil production in the Gulf of Mexico has been halted in preparation for Tropical Storm Isaac.
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Stone Creek Chalets
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Major Land Slides
The hope slide which took place in in January 1965 claimed the lives of 4 people. 2 were recovered and the other 2 are buried in the remains. The Frank slide happened in April 1903 and claimed 100 lives. The hope slide is in the Western part of the Rockies and the Frank slide in the Eastern part. Both are in the southern part of ...
In Canada, Eh?
... and told us we would have to go back into the US to sell Bessy before we left Canada on the 27 September (luckily our last destination is just on the border). He flagged our passports and said we could not leave the country until our license plate went back across into the US. Unfortunately for us, a guy Matt was chatting to at the local RV dump in Fernie said it would be worth the paperwork, we could get a lot more than we paid for her in Canada...so I guess we have 2 1/2 months ...
Powder hounds hit the slopes
... speed as well.
The team at the first aid station were great ,checking him out for concussion and substance abuse etc etc.. and the best part was , it was all free.
He is fine now, back on the beers and not seeing double anymore so his pool games can only get better....
They encourage helmets now and I can see why – compacted snow does hurt..
More news and stories as the adventure continues
The Powder Hounds
Light day
... We head up for Kootenay NP, taking the old highway in which they say there are more chances to see wildlife. No way, we are not lucky today. A short stop at Vista Lake is all for today at Banff.
We enter Kootenay with no information at all, as I said, the visitor center is in the middle of the park, and I think there should be one at each entrance...
We stop at Marble Canyon, really nice, ...
Gurgle gurgle gurgle goes the creek...
... to find a nice cool lake or river for a swim after another day of warm driving. At check in at Mount Baker RV resort, the lady told us she was putting us right beside a stream, if we wanted to swim in there. Well, it turns out that the stream was more of a creek, with lots of little kids trying to catch tiny fish. We pulled up to our site, which was right beside a bridge, and the garbage and recycling cans. I gave Craig a look, and he immediately offered ...


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Introductory season for Mr Big Stuff. "Studly" is a very flashy sabino arabian stallion. He is a talented western horse with one of the sweetest dispositions…Stud Fee: $500
1997 3/4 Arabian Pinto Kaiyoum bred and very stylish. JC has large eyes, very pretty head, long neck and all the qualities you would expect from his…Stud Fee: $350
Dream Quest (Ali Jamaal x Calypso Tessa by Jamal Calypso) Foal Date: 10 Aug 1992 AHR # 0540247 - SCID Clear Breeders Sweepstakes Nominated Sire …Not Available


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What boots should I buy next?(17 Posts)
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Make a bold statement with these Derek Cardigan 7006 Green Tortoiseshsell eyeglasses. This perfect cat-eye design comes in rich green tortoiseshell acetate. To help show off your geek pride, the division and multiplication symbols are featured on the sides with the equal sign on the arms. For added comfort, the arms are attached with spring hinges.About the Brand
Derek Cardigan's vintage inspired line of eyewear reflects Derek's joie de vivre philosophy on fashion and life. Bold yet subtle, Derek Cardigan eyewear evokes the spirit of a swinging by-gone-age brought right up-to-date full of color, whimsy, joy and style.


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Dr. David C. Huang graduated from the Natl Taiwan Univ Coll of Med, Taipei, Taiwan (385 02 Prior 1/71) in 1979. He works in Costa Mesa, CA and 1 other location and specializes in Internal Medicine and Pulmonary Disease. Dr. Huang is affiliated with College Hospital Costa Mesa, Good Samaritan Hospital, Hoag Hospital Irvine and Hoag Memorial Hospital.
Internal Medicine, Pulmonary Disease
Medical School: Natl Taiwan Univ Coll of Med, Taipei, Taiwan (385 02 Prior 1/71); Graduated 1979
*This physician has multiple office locations. See Office Information for details.
301 Victoria St
Costa Mesa, CA 92627
1011 Baldwin Park Blvd
Baldwin Park, CA 91706
301 Victoria St
Costa Mesa, CA 92627
275 Victoria St Ste 1E
Costa Mesa, CA 92627
2301 Newport Blvd Ste A
Costa Mesa, CA 92627


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3 Reasons Why Molycorp Will Not Be Acquired [View article]
http://bit.ly/TgsnmkOct 27, 2012. 01:45 PM | 0 Likes |Link to Comment
Molycorp: A Second Chance: Part I of III [View article]Feb 9, 2012. 01:16 PM | 2 Likes |Link to Comment
Another table of interest http://bit.ly/owiwdY
Sep 30, 2011. 08:32 PM | 1 Like |Link to Comment
By the Way if you do not known or understand CREOs I suggest you get a copy of Gareth Hatch's latest publication Critical Rare Earths available here
http://bit.ly/ozktSB/Sep 30, 2011. 08:27 PM | 1 Like |Link to Comment
Just have a gander at this and you decide where you put your spare nickels or dimes.
http://bit.ly/nrdNGXSep 30, 2011. 08:23 PM | 1 Like |Link to Comment
Molycorp Share Offering and Financing Announcements Create an Overhang [View article]
While it could be argued that the core shareholders bought into the company at far lower pricers and are cashing out to diversify their investments, "this isn't diversification, this is an abandonment", Byron Capital Markets analyst Jon Hykawy told Mining Weekly Online.
Last month, Molycorp, refurbishing and expanding the shuttered Mountain Pass rare earths mine in California, announced that certain core shareholders were selling up to 11,5-million shares, equal to about 12% of the company.
On Tuesday, the company said insiders were selling another equal amount of shares, bringing the total to up to 24% of outstanding shares.
"One of the touchstones of investing is to watch what the insiders are doing," said Hykawy, addind that the dumping of shares by Molycorp's core investors could signal that they view that prices for the products that the company produces will decline significantly once its expansion is complete and Australia's Lynas Corp comes into production.
This echoes what Goldman Sachs analyst Malcolm Southwood said in a report last month – that the market for certain light rare earths could be in oversupply by 2013, leading to a drop-off in prices.
Does this signal the top of the market for rare earth stocks such as Molycorp? Remarked Hykawy: "I think the math is fairly compelling."
He said in a telephone interview that Molycorp, Lynas and Great Western Minerals, which is developing a rare earths mine in South Africa, would easily meet the world outside China's demand for lanthanum and cerium.
These light rare earths account for some 83% of Molycorp's planned production.
Hykawy has given Molycorp a "sell" recommendation, but recommends investors buy Great Western's shares, as it will produce a large amount of heavy rare earths, which he doesn't believe will suffer from the same flood of supply in the future.
Molycorp did not respond to telephone messages seeking comment.
The company announced on Tuesday that it would sell $200-million of convertible senior notes due 2016, with the option to raise this to $230-million.
The cash would go towards the phase-one and phase-two expansions at its Mountain Pass rare earths processing facility in California, where it aims to produce 19 050 tons of rare-earth oxides once phase one is completed by the end of next year, doubling this in phase two by the end of 2013..
Rare earths are used in a wide range of high-tech applications, including smart phones, hybrid cars, wind turbines and advanced weaponry.
China accounts for nearly 97% of the world's output, and has been cutting back production and exports, leading to a peak of investor interest in the metals, which were only viewed as an obscure grouping at the bottom of the periodic table a until about two years ago.
Shares in Molycorp dropped 6% on Wednesday morning to trade at $55.04 apiece on the NYSE.Jun 8, 2011. 11:10 PM | 2 Likes |Link to Comment
Why Goldman Sachs Is Dead Wrong on Rare Earths [View article]
pmem.ws/files/users/a/...May 23, 2011. 06:22 PM | 4 Likes |Link to Comment
Why Goldman Sachs Is Dead Wrong on Rare Earths [View article]
pmem.ws/files/users/a/...May 23, 2011. 05:31 PM | 4 Likes |Link to Comment
Great Western Minerals Group Valuation Is Not So Great [View article]
pmem.ws/files/users/a/...Apr 18, 2011. 07:46 PM | 5 Likes |Link to Comment
A Rare Earth Primer [View article]Jan 18, 2011. 12:16 PM | 0 Likes |Link to Comment
A Rare Earth Primer [View article]Jan 14, 2011. 11:39 AM | 1 Like |Link to Comment


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Still from 12/24 Karol Bagh
Still from 12/24 Karol Bagh in 12/24 Karol Bagh TV Show
Courtesy: Zee Tv
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TV Show 12/24 Karol Bagh
Celebrity : Smriti Kalra
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omg...smriti in dulhan costume...shez jst too young..aisa lg rha h ki skul k play m grls saree phni ho...suvreen types role suits u the best..lv u..
i love this pic,.it is veryy good.
Nakul?!?!?!Where's Abhi (neil)?!??!
smriti looks beautiful
but why nakul where is neill
If only that were neil!
smriti looks beautiful
she looks beautiful. lovely eyes


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The hotel provides 40 - 100% non-smoker comfortable rooms; 29 Superior, 8 Suites and 2 Senior Suites. Casa Andina also offers a spectacular Imperial Suite, fully equipped with a small living room and a balcony with a view of the streets of the city.
All rooms are equipped with stove, air conditioning, safe deposit box, iron, minibar, coffee kit and hair dryer.
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The two icons battle it out for holiday movie supremacy!
Pesci has a meeting with Kevin McCallister to discuss recent events.
Livin' With Home Alone
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The Sue's @ Canada's Got Talent - Sue1 Before The Audition (Sue Stretches)
The Sue's motivating and inspiring all the contestants at Canada's Got Talent Susan McCallister perform her routine stretches before the audition.
An audition tape for the feature film "Amazon Hookers From Space" http://www.ReadySetRoomates.com
Christmas With You (And Home Alone 2 Lost In New York)
Mudville cares about the holidays, friends, and family. But more importantly we care about an amazing 1992 sequel. Merry Christmas, ya filthy animals!
If 'Home Alone' Were Covered by the Local News
Major events were happening during "Home Alone." You'd think the local news outlets would be all over it. Here's 5 that would've been addressed.
6 Alternate Titles for Home Alone
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- Royals fall to Astros 5-2 in opener of AL Division Series Updated: Oct-09-15 1:06 am
KANSAS CITY, Missouri - The Kansas City Royals were in this situation last year, dropping the World Series opener to San Francisco before responding with victories in the next two games.
- Chris Young pitches Royals past Twins 3-1 Updated: Oct-03-15 1:34 am
MINNEAPOLIS - After watching Chris Young strike out the side in the sixth inning, Kansas City Royals manager Ned Yost approached his starter in the dugout to tell him he was nearing his pitch limit.
- Royals put big dent in Twins' wild-card bid with 3-1 win Updated: Oct-03-15 1:34 am
MINNEAPOLIS - The Minnesota Twins clubhouse, clouded so often this season by fog machines for the post-victory dance parties, was crystal clear and eerily quiet following the 160th game on the schedule.
- Abreu passes 100 RBIs in White Sox's 6-4 loss to Royals Updated: Oct-02-15 12:57 am
CHICAGO - Jose Abreu is in the company of Albert Pujols, and that is a very meaningful club for the White Sox slugger to have joined.
- Gomes helps Royals beat White Sox 6-4 Updated: Oct-02-15 12:36 am
CHICAGO - Kansas City Royals manager Ned Yost was sitting in his office in the visiting clubhouse when White Sox broadcaster Ken Harrelson walked in and offered him a lucky gold coin.
- Royals' Young goes 5 no-hit innings day after father's death Updated: Sep-27-15 6:55 pm
KANSAS CITY, Missouri - A day after his father died, Chris Young took the mound and paid tribute the best way he knew how.
- Medlen knocked out in fourth in Royals' 9-5 loss to Indians Updated: Sep-26-15 11:57 pm
KANSAS CITY, Missouri - Kris Medlen lost the rematch.
- Morales hits 3 homers for Royals in 10-3 win at Detroit Updated: Sep-20-15 6:00 pm
DETROIT - The Kansas City Royals signed Kendrys Morales last offseason to add some power to what had been a fairly punchless offense in 2014.
- Kendrys Morales has 3 homers for Royals at Detroit Updated: Sep-20-15 4:18 pm
DETROIT - Kansas City's Kendrys Morales has hit three home runs Sunday against the Detroit Tigers, and he also has set a team record with 15 total bases.
- Sano's homer sends Twins past Royals 3-2 in 12 innings Updated: Sep-10-15 1:37 am
KANSAS CITY, Missouri - The longer Miguel Sano stayed in the batter's box, the more confident Twins manager Paul Molitor felt that his big pinch-hitter would come through in the 12th inning Wednesday night.


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Casa de Diogo Cão - Vila Real, Portugal
in Pre-Victorian Historic Homes
A Casa de Diogo Cão, é uma casa no Distrito de Vila Real, onde nasceu o navegador português do século XV, Diogo Cão.
[Eng] The House of Diogo Cão, is a house in the district of Vila Real, where the XV century Portuguese navigator was born.
posted by: razalas
location: Vila Real, Portugal
date approved: 11/27/2012
last visited: never
Cadmans Cottage - Sydney, Australia
Oldest surviving residential building in Sydney, Australia.
posted by: BruceS
location: New South Wales, Australia
date approved: 11/24/2012
last visited: 11/12/2014
Palácio Nacional de Sintra - Sintra, Portugal
The Sintra national palace is unique amongst the royal mediaeval palaces in Portugal and the town's most distinctive building.
location: Lisboa, Portugal
date approved: 11/9/2012
last visited: 5/2/2015
Manoir Grant - Grant Manor, Valleyfield, Québec, Canada
Ce manoir est l'un des plus vieux édifices de Valleyfield.
This manor is one of the oldest buildings in Valleyfield.
posted by: Geuguy
location: Quebec, Canada
date approved: 11/3/2012
last visited: 6/24/2015
Charlton House - The Village, Charlton, London, UK
This splendid Jacobean house is in Charlton in south east London. The house was built between 1607 and 1612 for Sir Adam Newton, by John Thorpe, and is one of the finest examples of Jacobean domestic architecture in the country.
posted by: Master Mariner
location: London, United Kingdom
date approved: 10/23/2012
last visited: 10/27/2013
Carneal House - Covington, Kentucky
Historic house in the Riverside Drive Historic District in Covington, Kentucky
location: Kentucky
date approved: 10/22/2012
Fairfield House - Amherstview, Ontario, Canada
Pre-Victorian Historic Home in Amherstview, Ontario. Likely completion date was 1793.
posted by: mTn_biKer65
location: Ontario, Canada
date approved: 10/21/2012
last visited: 8/23/2014
St Fagans Castle - Manor House - Cardiff, Wales.
St Fagans Castle - One of the finest Elizabethan manor houses in Wales. The manor house built within the medieval curtain wall remains of a 13th Century Castle. Located in St Fagans, Cardiff, Capital of Wales.
posted by: veritas vita
location: South Wales, United Kingdom
last visited: 10/25/2012
Ty Mawr - Llantwit Major - Vale of Glamorgan, Wales.
Llantwit Major - The Great House, Ty Mawr in Welsh, is a late 15th century house with 17th century additions. It incorporates a number of defensive features and was associated with the Nicholl family, prominent local landed gentry.
date approved: 10/3/2012
last visited: 10/7/2012
Joseph Smith Homestead - Nauvoo, Illinois
The first home in Nauvoo of Joseph Smith, Jr, the founder of the Latter Days Saints movement.
location: Illinois
date approved: 9/15/2012
Sketty Hall - Swansea, Wales.
Sketty Hall has stood for nearly three centuries and, in that time, it has undertaken many changes under the direction of its various owners. In 1993 Sketty Hall was renovated and restored to its former glory as one of Swansea's finest buildings.
date approved: 9/5/2012
last visited: 9/10/2012
Trout Hall - Allentown, Pennsylvania
Historic and oldest extant house in Allentown, Pennsylvania.
location: Pennsylvania
date approved: 9/4/2012
Cyfarthfa Castle - Merthyr Tydfil, Wales.
Designed by Richard Lugar for the Crawshay family, the Castle was built in a year (1824-25). As a fortified house, that looked like a Castle. In 1910 it was converted to a museum.
date approved: 9/1/2012
last visited: 9/3/2012
Quinta da Cardiga - Golegã, Portugal
Quinta da Cardiga is still a magic place, full of stories whispered by the wind, in Ribatejo, a very peculiar part of Portugal.
posted by: Torgut
location: Santarém, Portugal
date approved: 8/30/2012
last visited: 7/19/2009
Schloss Ebenrain - Sissach, BL, Switzerland
The most important late-baroque country house in northwestern Switzerland.
posted by: fi67
location: Nordwestschweiz (AG/BL/BS), Switzerland
date approved: 8/22/2012
Bruckgut - Münchenstein, BL, Switzerland
A manor of the 18th century in the north of Münchenstein
Singleton Abbey - Swansea, Wales.
The nucleus of the house is a neo-classical villa, octagonal in plan, erected in 1784 under the name of 'Marino'. In 1817 The house was purchased by John Henry Vivian, who extended the property in 1827 and renamed it Singleton Abbey.
date approved: 8/21/2012
last visited: 9/24/2012
George Taylor Mansion - Catasauqua, Pennsylvania
Historic mansion in Catasauqua, Pennsylvania.
date approved: 8/1/2012
last visited: 11/16/2014
Lord Mansion - Kennebunk, Maine
Historic mansion in Kennebunk, Maine.
location: Maine
date approved: 7/25/2012
Wallingford Hall - Kennebunk, Maine
Historic farm house in Kennebunk, Maine.
date approved: 7/17/2012
Penrhyn Castle - Llandygai, Bangor, Gwynedd, North Wales, UK
Occupying a large area of land near Bangor, Penrhyn Park is home to the fantastical Penrhyn Castle; a magnificent, country mansion built from the profits of the slave trade.
posted by: Dragontree
location: North Wales, United Kingdom
date approved: 7/16/2012
last visited: 10/14/2012
Sen. John Holmes House - Alfred, Maine
Historic house now used a dance studio in Alfred, Maine.
date approved: 7/14/2012
Emery Homestead - Sanford, Maine
Historic house in Sanford, Maine.
date approved: 7/10/2012
Surrogate's Office and Collector's Office (1807) - Mt. Holly, NJ
This is one of the smallest government buildings you might ever find and it is in a house! The building is a single room structure painted to resemble the historic 18th century courthouse to the left of it.
posted by: Math Teacher
location: New Jersey
date approved: 7/8/2012
last visited: 11/11/2013
Aquilla Ridgway House (1834) - Mt. Holly, NJ
This large home takes up a corner lot at the intersection of Buttonwood & Garden Streets. Despite its age, it does not contribute to the historic district. A historical marker gives details to the home's history.
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Alzheimer's Disease Health Center
Alzheimer's Disease: Your Role as Caregiver
In this article
Caring for someone with Alzheimer's disease is a balancing act. You keep your loved one safe and comfortable, keep track of his medications and doctor's appointments, and give him your love and support. But your life matters, too. It's just as important to keep up with your work, family, and social life.
In your role as a caregiver, do what you can to bewell informed and prepared, and ask for help and support when you need it.
Recommended Related to Alzheimer's
Assisted Living Facilities for Alzheimer's Disease
When someone with Alzheimer's disease can't live alone anymore, an assisted living facility is one way to make sure she gets the care and attention she needs in a safe place. The decision to move is not an easy one for you, your loved one, and your family to make. Here's how to tell if it's the right option for your loved one's situation and how to choose a good facility.
Read the Assisted Living Facilities for Alzheimer's Disease article > >
Know What to Expect
It helps to keep in mind how the disease affects people who have it. If you know what changes to expect, it can help you understand how your role may be different with time.
- Alzheimer's disease is different for everyone who has it. A person's condition can change a lot. There may be times when your loved one seems pretty normal and can handle his usual activities. Other times, he may be very dependent. The way medications affect him also can vary. The changes can be confusing and may make your loved one seem demanding or dishonest. But it's just a natural part of the disease.
- Your loved one's symptoms will get worse as years go by. While medicines can slow down this progress, they can't stop it.
- Depression is a part of Alzheimer's as well. It can make symptoms worse and change how well your loved one manages day to day. It's important to know the signs he might be depressed and let his doctor know right away.


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Men's Custom Polos$29.992-3 Weeks. Shipped direct from Supplier.Add your program or Scouting-event logo to a great-looking, high-performance shirt that's also designed to keep you cool, dry, and comfortable. Solid-color polo features a lightweight and breathable performance pique fabric made of 96% polyester/4% Spandex. Featuring: ● Wicking properties to transfer moisture away body―you stay cooler and drier ● Antimicrobial technology to fight odor-causing bacteria ● UPF 40+ rating for excellent sun protection Includes no-roll collar and Boy Scouts of America® engraved buttons for lasting good looks. Available in white, navy, orange, or red. Imported. Custom logo embroidery option may be added to wearer's left chest. Choose one of 17 official BSA® logos, and add one or two lines of custom text, up to 17 characters each, underneath the design. Please allow 2-3 weeks for delivery. Sizes S-4XL. Learn More
Journey to Excellence Tie$24.99Wear this distinctive design to support your area's Journey to Excellence efforts. Gold tie features an allover French fleur-de-lis design in navy. Polyester. Imported. Available online only. Learn More
Custom Fleece Blanket$27.992-3 Weeks. Shipped direct from Supplier.Personalize this fleece throw with your name and troop number. Custom logo embroidery option will be added to the corner of the blanket. Choose from one of 17 official BSA® logos. Customization will be added below the design. Allow 2-3 weeks for delivery. While supplies last.
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Cub Scouts® Panther Vision POWERCAP®$21.99Combines patent-pending Ultra Bright LED technology with a premium, compression-fleece beanie for the perfect hands-free flashlight. Learn More


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Hotel address317-319 Great Eastern Highway
How to reach the hotel
Contact the hotel
- Tel. (+61)8/94782158
- Fax. (+61)8/94771850
- firstname.lastname@example.com
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ibis budget Perth Airport - hotel reviews in Perth
Hotel code: 5676
Accorhotels.com customer reviews in partnership with TripAdvisor
"Only use if desperate for budget hotel near Perth Airport"
7th September 2013, Gill M
On the plus side the room was clean and the hotel the closest to Perth airport. Our room was on the second floor, but there is no lift which is surely a requisite for an airport hotel. The bathroom was very small and the handbasin so narrow that it was impossible to get head over the sink to use. No bad mat provided. No in room tea and coffee making facilities. Room was very basic with only furniture other than the bed one small desk. Only one light for the room. The blind had to be fully up or down. Although we paid $134, it wasn't value for money.
These prices may be based on different room types. Depending on the country, these prices may not include taxes, may include VAT only or may include all taxes (VAT and city tax). When prices do not include all taxes, the relevant taxes (VAT and/or city tax) will be stated in the following stages of the reservation process. The price is only guaranteed at the time of reservation.
2. Paying
Hotel classifications (1 to 5 stars for France) correspond to criteria laid down by local regulations.


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New York hardware stores are seeing a jump in storm supply sales as many residents prepare for the possibility of Hurricane Joaquin's arrival.» Read More
In extended trade, shares of Disney surged as much as 4% after the Mouse House topped Street forecasts. What must you know before you trade this stock on Friday?
With major retail names set to announce earnings this week, the sector will be a major focus of the market. Here are the names to watch from a top analyst.
Much has been made of magazine covers/stories as contrary indicators to the stock market, but one publication seems to be specifically dead on in its trading analysis: The Onion.
The Fast Money crew likes Wal-Mart, even more so after a recent breakout from a triangle formation — a very bullish indicator for the retailer.
For the first time in two weeks, the Dow closed above 10,000. Now all eyes are on the jobs report out Friday before the bell. How should you put money to work?
Remember how bad things were last year? Then stop crying about one bad week in the markets.
We asked the traders for their favorite stocks to 'buy and hold' for the long-term. After all, good things come to those who wait!
Despite a weak start to the last week of October, the Dow and S&P are now both up 2.58% and 0.85% for the month as of Thursday's closing session. Even though October ranks as a slightly positive month historically on average, up more than 53% of the time for all three major U.S. Indexes, the Nasdaq Composite has trailed behind, currently down 1.2% month to date.
With Microsoft's earnings report this morning, two thirds of the Dow 30 have now reported. Here is a summary of how things stand in terms of EPS and revenues.
The Dow slipped below the psychologically important 10,000 level on Wednesday after the market took a turn for the worse in the last half-hour of the session. What must you know?
Cramer pulled together a dozen names that he thinks will most benefit from an economic rebound.
Stocks retreated Tuesday after several earnings reports beat expectations but economic numbers missed their targets. The Dow shed more than 50 points, or 0.5 percent, but still held above 10,000. The S&P and Nasdaq each lost about 0.6 percent.
Following my post earlier this week on the highest yielding stocks in the Dow, here is a deeper look at the dividends of the S&P 500.
The S&P 500 eked out its 6th consecutive day of gains on Monday to end at its closing high for the year as energy shares rose alongside the price of oil.
Plus, get calls on earnings, housing, tech, autos and more.
Two and a half months away from the end of the year and the average dividend yield of the Dow 30 has continued to fall since the market lows. See how the 30 companies in the Dow compare.
Stocks rebounded Thursday after jobless claims beat and Alcoa kicked off the earnings season with exactly what analysts wanted to see: revenue growth.
The markets will continue to grind higher, propelled by forthcoming reports that will show growing strength in the economy, said Alec Young, equity strategist at Standard & Poor's, and Benny Lorenzo, CEO of Kaufman Brothers.
Stocks rebounded Thursday after jobless claims beat and Alcoa kicked off the earnings season with exactly what analysts wanted to see: revenue growth.
Cramer has a plan to get you through.


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I love trying new things, traveling to adventurous locations and learning about almost everything. My friends are incredibly important to me and I like spending my time relaxing with them during lengthy conversations over dinner, board game nights, attending cultural events and going to Tigers games in the summer sunshine! I like to keep active and enjoy dancing, socially and competitively. I'm very affectionate and looking for a smart and kind partner who is interested in making me laugh and creating fun experiences together.
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traveling and dancing.
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my loud laugh!
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Mátyás Kir. U. 92-94, 2025 Visegrad, Hungary
Visegrad, Hungary - 277 m from city centre see map
Property Location Located in Visegrad, Patak Park Hotel is in the mountains and convenient to Visegrad Bobsled Track and Visegrad...
Property Location Located in Visegrad, Patak Park Hotel is in the mountains and convenient to Visegrad Bobsled Track and Visegrad Citadel. This hotel is within the region of Triumphal Arch and Art Collection of Vác.Rooms Make yourself at home in one of the 30 guestrooms featuring minibars. Your room comes with a pillowtop bed. Complimentary high-speed (wired) Internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have bathtubs or showers and hair dryers.Rec, Spa, Premium Amenities Pamper yourself with onsite massages or enjoy recreation amenities such as a sauna. Additional amenities include complimentary wireless Internet access, an arcade/game room, and wedding services.Dining Enjoy a satisfying meal at a restaurant serving guests of Patak Park Hotel. Quench your thirst with your favorite drink at a bar/lounge.Business, Other Amenities Featured amenities include complimentary high-speed (wired) Internet access, express check-in, and a 24-hour front desk. Planning an event in Visegrad? This hotel has facilities measuring 861 square feet (80 square meters), including a meeting room. A roundtrip airport shuttle is provided for a surcharge (available on request).
11. Straße 43,2 ? 43,5 Km, H-2025 Visegrad, Hungary
Visegrad, Hungary - 1.2 km from city centre see map
Property Location With a stay at Royal Club Hotel in Visegrad, you'll be convenient to Visegrad Citadel and Visegrad Bobsled Track. This...
Property Location With a stay at Royal Club Hotel in Visegrad, you'll be convenient to Visegrad Citadel and Visegrad Bobsled Track. This 4-star hotel is within the region of Triumphal Arch and Szentendre Skanzen Village Museum.Rooms Make yourself at home in one of the 52 air-conditioned rooms featuring minibars. Rooms have private balconies. Complimentary wireless Internet access is available to keep you connected. Conveniences include phones, as well as safes and desks.Rec, Spa, Premium Amenities Dip into one of the 2 outdoor swimming pools or enjoy other recreational amenities, which include a sauna.Dining Enjoy a meal at a restaurant, or stay in and take advantage of the hotel's room service (during limited hours). Relax with your favorite drink at a bar/lounge or a poolside bar.Business, Other Amenities Featured amenities include a business center, a 24-hour front desk, and luggage storage. Planning an event in Visegrad? This hotel has facilities measuring 1076 square feet (100 square meters), including meeting rooms.
Fö Ut. 9, 2025 Visegrad, Hungary
Visegrad, Hungary - 1.7 km from city centre see map
In the name of our whole team, we welcome you enthusiastically to the Hotel Vár Wellness-Schloss. Castle Hotels are easy to find, but...
In the name of our whole team, we welcome you enthusiastically to the Hotel Vár Wellness-Schloss.
Castle Hotels are easy to find, but they are not all created equal. Make the right choice and book a room at this quaint hotel to enjoy all of its features and benefits!
Do you need a car park or secure area to park your bike during your trip? We have heaps of car parking spaces and secure zones for parking bikes of all kinds.
Free for you
On arrival at the hotel you will receive a free welcome drink.
The use of the hotel sauna is included in your stay and comes at no extra cost.
If you are arriving by car, we have free parking directly at the hotel.
Make yourself at home
For peace of mind use the hotel's safe at reception.
A garden terrace is also provided.
Culinary greetings from the kitchen
Vegetarian dishes are available for our guests in our gourmet restaurant.
Where you will stay
The TV sets in our hotel have satellite programmes.
From the comfort of your room you can stay informed about global affairs with the newspaper available to.
In your appealingly arranged room you will find a the well-stocked minibar.
In every single room a convenient landline is included.
Hotel guests can enjoy the comfort of windows in the bathroom.
In each room at our hotel we offer a bathroom with a shower.
Relax or be active
In our hot tub and sauna you will be able to enjoy long hours of pure tranquillity.
An archer's court, where you can shoot a bow and arrow, is offered at the hotel and is a true crowd-pleaser among our hotel's visitors.
During your visit in our hotel enjoy some of our leisure activities, such as our exciting toboggan run.
During your stay at the hotel partake in some of the leisure activities, like horseback-riding.
There are paths provided at the hotel for you to take a break. Simply grab your co-travellers and go for a walk.
Business hours of reception:
Every day: from 00:00 to 00:00
Rév Street 15, 2025 Visegrad, Hungary
In the name of our whole crew, we welcome you warmly to the Hotel Visegrád.
Spa Hotels are easy to find, but they are not all created equal. Make the right choice and book a room at this modest hotel to enjoy all of its features and benefits!
We have plenty of car parks and secure areas for those arriving on motorbike.
Free for you
The use of the hotel sauna is included in your stay and comes at no extra cost.
Beach chairs are available which you can use for free.
Free parking is available at the hotel.
Make yourself at home
Our lift is available to take you to the upper floors of the comfy hotel.
Our lobby is kept under video surveillance.
A garden terrace is also provided.
A family-friendly atmosphere is a high priority at this hotel, which features a children's play area and has non-smoking rooms available upon request.
Culinary greetings from the kitchen
During the day make for our restaurant and grab a bite to eat. Appropriate meals for our vegetarian guests are on the menu as well. Afterwards conclude the day with a liquid refreshment at our bar.
Where you will stay
A desk, a radio, a safe as well as a blow-dryer are standard in all of our hotel's comfortable rooms.
Our hotel offers numerous conveniences to make your time here at our hotel more enjoyable, for instance a minibar, cable TV and a telephone are at your ready in each room.
All of the hotel rooms feature satellite TV.
After you get out of the shower, use the hair-dryer available to dry your hair off.
The sound proof windows in your room ensure a peaceful stay.
Relax or be active
The wellness offerings in the hotel will be of interest to those of our guests looking for rest, relaxation and harmony. These consist of facilities such as the steam room, tanning shop and sauna and also the hot tub.
Our guests are invited to use the modern fitness room.
Business hours of reception:
Every day: from 00:00 to 00:00
Pf.1 Kospallag - Nagyirtaspuszta, 2625 Nagymaros, Hungary
Nagymaros, Hungary - 5,622.2 km from city centre see map
Tabor U. 1, 2621 Veroce, Hungary
Veroce, Hungary - 1.2 km from city centre see map
Arpad Ut. 38, 2621 Veroce, Hungary
Veroce, Hungary - 577 m from city centre see map
Vaci Ut 27, 2626 Nagymaros, Hungary
Nagymaros, Hungary - 487 m from city centre see map
Hotels Kospallag with special offers and the lowest price guaranteed.
Our search engine for hotels in Kospallag will show you the best prices, allowing you to find budget and economical hotels in Kospallag. You can make your booking immediately, with no queues or waits.
Our search engine enables you to book any type of hotel in the city of Kospallag, allowing you to select the best offers for either luxury hotels or a wide range of budget hotels and hostels in Kospallag. In order to do this, just enter the name of the city, choose the arrival and departure dates, select the number of occupants and type of room, and click on find hotels. As an extra option, you can also search by category and/or accommodation regime, from 'accommodation only' to 'all-inclusive'.
Once you have made the search for a hotel in Kospallag we will show you an extensive list of offers, ordered in accordance with our criteria. Obviously the results can also be ordered by name, category, approximate price or based on the evaluations by our clients. We also provide a small description of the accommodation in Kospallag that you selected, so that you can decide whether or not it responds to your expectations.
In the cheap hotels in Kospallag search results, you can filter and find hotels ranging from those with hot tubs to those with spas to allow you maximum relaxation. For instance, one of the most frequent queries to escape the summer heat are for hotels with pools. You will also find other types useful filters, such as those that select hotels with access for disabled people, with restaurants or with Internet access. Of course you can also find medium to high category accommodation, such as a four-star hotel in Kospallag.
In addition, we also provide you with the location of all the accommodation on a map, so that you can choose a hotel in the centre of Kospallag or near the place that interests you the most. We know that many of our clients want central hotels in Kospallag or those that are near certain points of interest, so if you want a hotel in Kospallag near a specific site, check out this filter as it could be useful.
On the other hand, our search engine also works to help you find more specific types of accommodation, such as a charming hotel in Kospallag. If you just want to spend a few days with your partner, you can also book romantic hotels in Kospallag. Our principal aim when you search for hotels in Kospallag is to provide you with the best offers and the highest quality.
The detailed information on each hotel includes its address, whether it has a minibar service, its telephone number and whether it offers free services.
Find your hotel in Kospallag now, with our cheap hotels search engine!


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Netty P Photographer
Eat the Cake NYCPhotographer Male New York, New York, US
My Website: Eat the Cake NYC - photos by Chris CarrMy MM URL: http://www.modelmayhem.com/stoneyashes
Mayhem # 826121
About Me
I am a photographer in NYC that is willing to travel. I would like to create awe -inspiring, intensely vivid images that force the observer to question , sexuality, identity and the relationship between the observer and participant....oh...basically create images that are aesthetically gorgeous.
i am currently casting for nude models for an art show that I am putting together titled, "FLESH" .. an exploration of the human form, sexuality and social acceptance.
hit me up at email@example.com
I have shot a ton of people on model mayhem... if you would like some references, just send me a note.. Thanks
Netty P Photographer
Kristin Glamazon Model
Kitty Crystal Model
Nikki Delano Model
Chrstina Stoll Photographer
SamHyde Model
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iPhone & iPod Skins by Erica Manami
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Stay here April 2013 with a stay,park and fly rate. I loved the way the room was set up, there was not just a partition between the bedroom and the living room but a full wood door, which is great when you want some rest and your travel buddy wants to watch t.v. There was a balcony with chairs so you could enjoy the nice weather. Breakfast was typical, not real appealing. The cost of the room plus leaving my vehicle for 8 days was a bargain. The shuttle left the hotel promptly and picked us up at the airport within 15 minutes of my call. Next time I fly from DFW I will definitely return to the Comfort Suites DFW Airport.
- Official Description (provided by the hotel):
- The Comfort Suites® DFW Airport hotel is centrally located between Dallas and Fort Worth, providing easy access to the Dallas/Fort Worth International Airport. This Irving, TX hotel is close to popular attractions like Grapevine Malls mall. The Fort Worth Stockyards National Historic District, Cowboys Stadium and Six Flags Over Texas are within 20 miles. Come experience the new look of our newly renovated hotel. Some of the updates include new carpet, paint and furniture in the lobby, breakfast room and meeting rooms. Our guest rooms have new furniture, appliances and bedding. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Orbitz, Expedia, Booking.com, Travelocity, Hotels.com, TripOnline SA, Odigeo, Choice Hotels, Agoda, Priceline and Low Cost Holidays so you can book your Comfort Suites DFW Airport reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Comfort Suites Dfw Airport Hotel Irving
- Comfort Suites Irving
- Dfw Airport Comfort Suites
- Irving Comfort Suites


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Manchester Jobs
Looking for jobs in Manchester? Snagajob has great opportunities with the area's leading companies. And applying for Manchester jobs has never been easier. Look at the job listings below, click on a job title that interests you and hit the "apply now" button. Part-time jobs, teen jobs, student jobs and summer jobs are now just a click away. Start your job search now.
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José Zúñiga
Actor José Zúñiga Movies / Films:The Call (2013) aka The Hive (2013) Twilight (2008) Constantine (2005) aka Hellblazer, John Constantine: Hellblazer (2005)
Reviewed Movies Starring José Zúñiga
The Call (2013)
I love Halle Berry, and it is not my love for her that I say this movie is awesome. The suspense kept me reeled in and on the edge of my seat. The events in this movie can actually happen in reality,…
Constantine (2005)
Warner Brothers Constantine (Blu-ray)In the grand scheme of theological thrillers, Constantine aspires for the greatness of The Exorcist but ranks more closely with The Order. Based on the popular Hellblazer…


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However, the CDC reports that good control of blood sugar levels can decrease the risk of complications. For each percentage point drop in A1C levels -- a long-term measure of blood sugar control -- the risk of eye, kidney and nerve damage drops by 40 percent, according to the CDC.
"It's not enough to just know your blood glucose, cholesterol and blood pressure levels. You need to take action and do something about those risk factors early -- and long-term," Pedersen said.
Of Steno-2, Gerstein noted that the study shows that for people with type 2 diabetes and microalbuminuria, doctors "should use a comprehensive approach to reduce as many risk factors as possible."
Both study investigators said their findings are only applicable to those people with type 2 diabetes, not those with type 1.
More information
To learn about preventing type 2 diabetes, visit the National Institute of Diabetes and Digestive and Kidney Diseases.
SOURCES: Oluf Pedersen, M.D., D.M.Sc., principal investigator, professor and director, Steno Diabetes Center, Copenhagen, Denmark; Hertzel Gerstein, M.D., principal investigator, ACCORD study, and professor of medicine, McMaster University, Hamilton, Ontario, Canada; Kirit Tolia, M.D., endocrinologist and director, Joslin Diabates Center, Providence Hospital, Southfield, Mich.; Feb. 7, 2008, New England Journal of Medicine
|Copyright©2008 ScoutNews,LLC.
All rights reserved


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minz, give us some insight on your conversation you had with him..
Type: Posts; User: adamant
minz, give us some insight on your conversation you had with him..
I would like to start making hot pepper honey. For those who do it can you tell me your process? Thank you Ant
rich, thank you for shairing
talstar insecticide works well on ticks
what size drain holes
did you purchase a automated bottler?
zhiv9, do you draw out of buckets or do you have a tank set up to draw out of?
do you have to clean the unit between each use?
when you are finished for the day do you have to drain the unit (i have a unheated honey house)
grozzie2. thank you for taking the time to right back. your post was helpful.
I am in the need to up grade my bottling system. I am looking into the mannlake ez fill. Can you guus who use it explain your setup? I currently use a maxant 300 lb bottling tank .
Some questions...
surprised when a farmer asked me that he has a extra plot of land that he is willing to plant a food plot for bees. he asked me for recommendations.. i am in new jersey. what to maxamine this...
Most likely it will be available to us to use as a mite treatment in America. My question is.. To vaporize or dribble?
i like the idea of the jenter system! i came across the ml one . both look the same.
question is ..
are they worth it?
have you had good success using this type of kit?
i am sure as soon as the usa gets approval you will see different vaporizers hit the market!
it seems that not getting e mail notices on the threads i am subscribed . are anyone else having the same issue?
here is adamant
wolf, explain please
yes david please share more about your jig please
nice.. i am liking that jig


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Search the Collection
Sitter in 1 portrait
by Jeremy Grayson
Barry Emmanuel Tuckwell(1931-), Horn soloist and conductor
Sitter in 1 portrait
by Jeremy Grayson
bromide print, 15 February 1980
NPG x27074
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- Detail Images
- Community Images
A fully padded pack built for the crag.
From the famed bullet blue limestone of Ceuse to weekly project sessions at the local sport crag, you can keep your kit stowed in the climb-specific Arc'teryx Miura 45 Backpack. The surround zipper allows the bag to open completely flat, which makes gear easy to access and allows the pack to double as a rope bucket. The C² Suspension System takes the sting out of longer approaches, and the hydration-compatible port and tube clip make it easy to quench your thirst on the go.
- C² Suspension System utilizes high-density foams laminated to a quick-dry back panel that keeps the pack close to the body for greater efficiency and reduced load movement
- Ergonomically shaped shoulder straps are padded with EV 50 closed-cell foam for comfort and have a Spacermesh lining for improved ventilation
- Surround zip closure opens wide like a clam shell to provide easy access to gear
- Pack opens completely flat for use as a rope bucket
- Burly nylon fabrics are exceptionally smooth and highly abrasion resistant, and padding helps protect your gear
- Hydroport and Hydra Clip tube make the bag compatible with a hydration system (reservoir not included)
- Internal zippered pocket is ideal for tape, clippers, files, and other climbing essentials
- Dual front zippered pockets hold guidebooks and maps
- Top zippered pocket keeps keys and valuables securely stowed
Share your thoughts
What do you think of the
Arc'teryx Miura 45 Backpack - 2562-2867cu in
? Share a...
Is this for male or female? The Miura falls under "Men's" category on Arc Teryx' website but this color looks a bit feminine...
Jared Downs, Gearhead
This pack can definitely be used by either male or females.
Shoot me an email anytime you have questions!
Jared D.
Expert Gearhead
Great pack, forget old Miura comparisons
- Familiarity: I've put it through the wringer
I bought this pack for cragging and approaches where you won't be climbing with it. It's almost perfect for that purpose, with a huge capacity that holds a 70m, double trad rack, 3L water and food. The pack carries well and is durable, comfortable with few other frills for better or worse. The material is burly and I like the off-gold color. There's a four handles, one for each side of the backpack which makes it easy to handle and maneuver.
Theres a total of four pockets. The pockets are large. The pockets expand into the pack when you put stuff into them, which eats some space inside, but I think this is a great tradeoff. There's so much room already that you can usually manage unless you are really hauling. (I've fit a DSLR in the top pocket!). This interior pocket design means a smooth exterior, important if you are doing a manky or bushy approach. This packability is seriously underrated and useful when you are stuffing this pack into a trunk loaded with gear.
This also fits as an airplane carryon, which is pretty awesome since it is huge.
I don't like the zippers going backwards over the "brain", which makes them slightly harder to open, but I suspect this was a reasonable tradeoff considering its ergonomics.
So why the hate from other reviews online? Well the old Miura was a classic arcteryx pack for hiking/backpacking/major approaches. The old school Miura had alot of pockets and features. This new Miura isn't even close to the same product. To try to be helpful, people said to think of this new Miura like "a duffel bag" with straps. It's clear this bag has been designed with alot more structure than a duffel bag so it carries really nice. But it sort of is a good way to think of it. Like a super comfortable, burly bag that you stuff cragging gear into.
I wouldn't pay $230 for it but I got it at a significantly lower price, which was basically a steal. Get a sale.
Greg Hill, Sponsored Athlete
Grab and go
- Familiarity: I've put it through the wringer
This bag holds all my essential climbing gear and allows me to get home from work, grab the bag, knowing everything is in there and ready to go.
Everything for sport climbing that is. Trad gear is a little too much, with 60 m rope, water, harness....
Then the ease of access and opening make it a great crag pack. Pair it with the Arcteryx Haku rope bag and your system is dialed.
High class duffel bag.
This pack is fantasticly simple and is basically a duffel bag with really nice shoulder straps. It excels for simple days at a local crag or for tossing your gear in to head to the gym. The fold flat design is pretty cool and allows you to access all of your equipment very easily. It is also a very good pack to travel with. The numerous handles and minimal exteriour features make it a easy to toss this pack into overhead compartments on planes and trains. The fact that the entire pack is padded also helps protect your things. I have not been happy when loading this down with a full trad rack or on any longer approaches. Also if you reach capacity with your rack, down jacket, etc... it is difficult to attach your rope externally.
If you had a previous version of a miura and are looking for something similar, this is not it. Most techincal features have been taken away, but at least you look cool when there are people watching you.
Cameron C, Gearhead
Sideways Stash
Fits everything I need with ease. The design is so easy to load and unload.
anyone know the linear dimensions of this...
anyone know the linear dimensions of this pack? 45L might be awkwardly large for a backpack without any straps, if it is not loaded to capacity
Let me know specifically what measurements you'd like and I will measure mine. As you said, if not loaded to capacity it can be a bit awkward. However there is a gear loop near the top of the back panel where you can attach heavier items to keep the load inbetween your shoulders.
Here is a quick video that might answer some questions: http://www.youtube.com/watch?v=mHmL2bRm4iQ&feature=em-upload_owner
why did they have to ruin everything i...
why did they have to ruin everything i liked about the fifty?
did you date their sister? sometimes people are touchy about that...


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Worst customer experience! 20 min for 3 bagels&coffee-cashier couldn't make change-didn't get what we ordered-food cold! #howhardisit
Food is good, coffee is better. But they constantly get my order wrong and their customer service (or lack thereof) is absolutely horrid. They need new management stat!
Try ghe Cookie crumble lattes
Autumn Roast is very good coffee. Bring your own mug and you can get a cup for $1.10
Try the jalapeño smear on any bagel. The vanilla hazelnut coffee is out of this world!
Love the Good Grains bagel with Garden Veggie schmear. Try it!
Way too expensive and they NEVER fill my latte to the top, but I keep coming back bc I love the breakfast thin bagel sandwiches!!
The lox rocks!