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Search Results: 'science of perception'
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In the year 2032 a series of strange and unexplained UFO sightings will occur throughout the world. Having been overwhelmed with science fiction depictions of alien spacecraft and apocalyptic... More > results; all of humanity brace and prepare for war. All but one single man knows the reality of what is about to happen. He alone must bear the weight of that knowledge and what actions to take. He alone knows these visitors are not what they seem. He alone knows their capabilities and most importantly their origins which far exceed the imagination of any. In a myriad of changing circumstances and varying perceptions of reality, all struggle to keep up and understand. Before the end, humanity in all of its developmental stages will combine and engage in a chess match between what is real and what is perceived. Unlikely alliances will form, mass hysteria ensue and none will be left untouched. Humanity both past and present will be forever changed in the delicate and interlocking web of time and events.< Less
Realm Perception
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Three women who each have a special gift discover that their gifts have a reason greater than they can imagine.
New Perceptions
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Art Perception
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A complex and fascinating question is why do humans have such strong emotional reactions and human connections to art? Why do viewers become scared, even haunted for days, by a movie monster they... More > know doesn't exist? Why do humans become enthralled by distorted figures and scenes that aren't realistic? Why do viewers have emotional attachments to comic book characters? The answer lies in that, while humans know art is human made artifice, they view and decipher art using the same often nonconscious methods that they use to view and decipher reality. Looking at how we perceive reality shows us how we perceive art, and looking at how we perceive art helps show us how we perceive reality. Written by the prominent art historian and philosopher Cycleback, this book is a concise introduction to understanding art perception, covering key psychological, cognitive science, physiological and philosophical concepts.< Less
Perceptions of the Paranormal
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This book asks the questions and opens deabte on ghosts and aliens, it ponders the idea of a universal energy that guides us, and asks 'is this God?' It contmeplates the responsibility of science in... More > the paranormal, and looks at our perceptions of truth and reality. It has features debating for and against time-travel, life after death and aliens.< Less
Perceptions of the Paranormal
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This book asks the questions and opens deabte on ghosts and aliens, it ponders the idea of a universal energy that guides us, and asks 'is this God?' It contmeplates the responsibility of science in... More > the paranormal, and looks at our perceptions of truth and reality. It has features debating for and against time-travel, life after death and aliens.< Less
Binaural Beats and Pain Perception
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An enlightening collection of Insights into the human condition ranging from spiritual and socialogical topics to scientific and the esoteric.
Sixth Sense ( Extrasensory Perception )
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The original price of this book is estimated at 8 trillion American dollars. Reason; In the science fiction methodology that this book envisages, the well known inter-planetary based professor has... More > gathered around him a very well balanced and professionally adept group of interplanetary deep space personnel. These well trained outer space personnel are drawn up from their respective space stations including Earth and Uranus -- Forward space research stations. The mission; Is to make this select group of inter-planetary humans aware about the proper working and availability of knowledge pertaining to -- Extrasensory Perception. They must be groomed within a very short time and be prepared to accept this extraordinary method of Human Inherent values. It is the professor's duty to teach and train this interplanetary deep space personnel group. They in turn, must listen and deliberate to the professor's lectures.< Less
Cognition, Perception and Limits of Knowledge
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"Looking at visual illusions and how they work show us that reality and human perception of reality are different things." Written by prominent art historian and Eric Hoffer Award... More > Finalist David Cycleback, this alternately academic, offbeat and poetic work includes previously published books CONCEITS and I MISS ME TOO. Written as an assortment of short essays, CONCEITS is a mind bending look at peculiarities, curiosities and limitations of human thought and perception. Topics include visual illusions, the psychology of hitting a baseball, art perception, the psychology of numeral systems, limitations of science, blind spots of logic and common everyday misperceptions of reality. The quirky and unsettling I MISS ME TOO touches on previous ideas of narrative and ambiguity and the more personal subjects of love and mental illness.< Less
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In recent years, cloud computing has gone from buzzword to product-label used by virtually every IT vendor that does business with the federal government. And according to David Cearley, tech visionary and futurist at Gartner, that might not be a good thing.
"Can you think of a vendor who doesn't have something labeled 'cloud?'" Cearley asked an audience at the Federal Cloud Computing Summit on May 30.
"When cloud means everything, then cloud computing really loses its meaning," Cearley added, prefacing his 40-minute presentation. The presentation itself comprised a crash course in cloud computing for the fed-heavy audience, beginning with its definition and ending with what agencies need to think about if they want to employ it.
The definition of cloud computing
The basic definition, as provided by Gartner: "A style of computing in which scalable and elastic IT-enabled capabilities are delivered as a service using Internet technologies," Cearley said.
Cloud services can be provided in numerous ways.
Private clouds and hosted private clouds are two of the most popular options federal agencies currently favor, in part because they address the most serious security concerns that some agencies – especially those dealing with sensitive information – routinely voice.
Public cloud services, often used by agencies to stand up public-facing websites, are growing more popular, especially within agencies that have adopted cloud technology and are "ready to add security layers in." Agencies currently spend less on public cloud computing solutions than they do on any other option.
However, studies by Gartner show that federal agencies are beginning to shift their strategies toward hybrid cloud solutions, which are essentially combinations of private and public cloud infrastructure. Cearley, referring to a recent Gartner study, said 70 percent of feds report they will pursue a hybrid cloud strategy in the near future.
"Hybrid cloud aspirations are sky-high, hybrid needs to be on your list of topics when you're thinking about cloud computing," Cearley said.
How to decide what's best for your agency
Cearley said one of the biggest mistakes feds make in looking to the cloud is assuming too much, so he outlined a process agencies can follow to ensure they end up with the right cloud option.
Cearley said cost is always a factor when moving to the cloud, but he recommended agencies develop mechanisms to determine cost over time. Cearley warned not to "just assume cloud is cheaper" because in some cases, it might not be, but moving to cloud-based services might still be the right decision if increased agility is taken into account.
Security, too, is an important determinant for whether an agency might take or leave a cloud solution, but Cearley said too often "when people raise security, it's usually about their job security."
"Sometimes, they will be absolutely right, but look at security as a challenge to be addressed and evaluate it, not as a reason to not do anything," Cearley said.
Lastly, if you're in an IT shop putting together a cloud-based plan for your agency, Cearley said it is best to keep it simple. "Put the framework in a model that non-IT people can understand," he said.
Cearley recommended a simple "benefits vs. challenges" model, which works great with data-driven figures to bolster the argument. It also doubles as a rubric for what kind of cloud model best suits an agency's particular need.
When the benefits and challenges are both high, a private cloud – best for sensitive information – probably applies best. When the benefits are high and the challenges are low, Cearley said, that's a great time to try public cloud solutions.
About the Author
Frank Konkel is a former staff writer for FCW.
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The outgoing speaker helped push forward data and transparency measures that have opened up the House of Representatives to the American people.
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A technology roadmap can help agencies reap the benefits FITARA has to offer. Here are the four stages of a successful effort.
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Jack Hyer and Laura Jensen for the New York Times
Story here
Jack Hyer and Laura Jensen for the New York Times
Story here
Too many clouds for an eclipse shot last night, but the trees looked cool from the window.
Young Bucks. Brooklyn, New York.
Crazy Horse Memorial, South Dakota.
Pioneers. Hot Springs, South Dakota.
Sylvan Lake, South Dakota.
Mt. Rushmore, July 2015.
Kennedy, Reagan, Bush. South Dakota.
Former US Attorney General Eric Holder for the New York Times Magazine
Perdue Chicken Eagle Springs Hatchery for the New York Times
(And yes, all those crates are full of chicks. They process 1.1 million chicks a week)
Holiday Road……..
Working on an edit of South Dakota/western photos from this summer. I waited a long time to get an RV to drive through here.
Hurricane Katrina, 10 Years Later
This was one of the first big stories I ever covered, for a long gone photo agency out of New York. I got to New Orleans for the first Mardi Gras after Katrina, 6 months after the storm hit the city, and I will never forget getting out of the car in the 9th Ward and being so shocked by the destruction that I just stood there for several minutes, staring dumbfounded. Almost nothing had been done since the storm and the destruction seemed to go on forever. I spent a couple weeks wandering the city, talking to returning residents, the couple clean up crews I saw, and ventured out to a trailer park for folks who has lost their homes. The lawlessness was still there, a cop pulled a gun on me and another photographer for venturing onto their security "camp", and people were trying the best they could to put what they had left back in some kind of order.
I have been back since and it is good to see some things that were lost coming back to life, but I will say that no one I met had given up, they were just trying to get back to where they came from. The spirit remained, even when the material things were lost, and that seems to have continued. Lots of work still to do, but that city is a jewel, as are the people who make it so.
1. Adrian Love, age 9, lived in a trailer park for displaced residents w/ her father.
2. A train carrying trailers for the displaced residents of hurricane Katrina passes through the 9th Ward.
3. Video gamer controller, Lower Ninth Ward, New Orleans.
4. Abandoned Cadillac, Lower Ninth Ward, New Orleans.
5. Lloyd Lee stands on the steps where his house once stood in the Lower Ninth Ward of New Orleans.
6. A small crab, brought in by the flooding of the Lower Ninth Ward, was found in a TV in an abandoned house being cleaned out.
7. Lower Ninth Ward, New Orleans.
8. French Quarter, New Orleans.
9. An abandoned teddy bear, Lower Ninth Ward, New Orleans.
The Sylvia Circle Demons for ESPN the Magazine


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"Us Too" Prostate Cancer Support Group - Northtowns
November 03, 2015 | Tuesday -
7:00 pm to 9:00 pm
Upcoming Presentation on Tuesday, November 3
"Prostate Cancer: Prevention or Control"
James R. Marshall, PhD
Chair, Department of Cancer Prevention and Population Sciences
Roswell Park Cancer Institute
For info: 716-834-9200, x5169
More details about support groups are available. Unable to attend a support group? Visit our online patient community.
VA Medical Center (Room 301)
3495 Bailey Ave.
Buffalo, NY 14215


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I'm servicing my old Stumpy Expert Disc 120 from 2005. At the front, there's a Stout Disc hub which developed free play.
I'm trying to figure out how to open it and adjust it (or change the bearings) but the end cones on both sides have no apparent way of being removed.
Anybody has instructions or suggestions?
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Posts tagged with South Lawrence Trafficway
SLT on KDOT's to-do list
The South Lawrence Trafficway project is the second most expensive project on the state's transportation to-do list that was released Wednesday.
The estimated construction costs for the nearly six-mile stretch is $150 million, according to the Kansas Department of Transportation.
That was No. 2 behind the Johnson County Gateway interchange project at Kansas Highway 10 and Interstates 435 and 35 junction, which will cost $250 million.
KDOT put together a list of more than 430 projects that are under way or will be within the next year or so with a total pricetag of $1.1 billion.
"The majority of these projects are considered preservation work and will protect the investment Kansans have made in their transportation system," said Kansas Transportation Secretary Mike King. "But there are also some big projects that will expand capacity on some of the state's busiest corridors and spur economic development," he said.
The contractor for the SLT is scheduled to be picked in September 2013 with construction scheduled to start later in the year and completed by October 2016.
Last month, the more than 20-year legal battle to stop the SLT from running through the Baker Wetlands ended.
Gov. Sam Brownback has said building the SLT was one of his top highway priorities within the state's comprehensive transportation plan.
KDOT also included the $17 million interchange at Bob Billings Parkway and the SLT in west Lawrence in its priority list. That project is scheduled to start in the spring of 2014 and completed in late 2015.
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- Letter: Abortion protest October 6, 2015 · 26 comments
- SLT interchange at Bob Billings Parkway will be delayed and cost $2.1 million more because of sinking roadway October 6, 2015 · 13 comments
- Blog: Davis rejects GOP call to step aside from voting rights case October 6, 2015 · 7 comments
- Letter: Road scholars? October 6, 2015 · 13 comments
- 2 remaining City Commission candidates speak on upcoming issues; final decision to be made Tuesday October 5, 2015 · 20 comments
- Letter: Safest route October 3, 2015 · 54 comments
- Kansas inks efficiency study for $2.6M, rejecting lowest bid October 6, 2015 · 9 comments
- City commissioners elect Lisa Larsen to fill vacant seat October 6, 2015 · 3 comments
- Proposal for bike corrals, other downtown parking will soon go to committee October 5, 2015 · 5 comments
- Editorial: Disappointing news October 5, 2015 · 10 comments
- SLT interchange at Bob Billings Parkway will be delayed and cost $2.1 million more because of sinking roadway October 6, 2015
- KU, K-State provosts are finalists for chancellor's job at University of Arkansas October 5, 2015
- Column: Kansas not the worst, but close October 6, 2015
- Local numbers crunch: City golf teams field only three varsity players October 5, 2015
- Kansas GOP leader demands Davis exit from voter rules suit October 6, 2015
- Pharmacist-turned-FBI agent had key role in K.C. investigation May 29, 2002
- Firm hired to find Kansas efficiencies has track record of cost overruns, mixed results October 4, 2015
- Proposal for bike corrals, other downtown parking will soon go to committee October 5, 2015
- Opinion: Pact's collapse raises Mideast risk October 6, 2015
- Eyeing a start: With Cozart, Ford out, KU turns to Willis October 6, 2015


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Resmi Mustarichie et al. / Int. Res J Pharm. App Sci., 2012; 2(4): 56-61 International Research Journal of Pharmaceutical and Applied Sciences Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2012; 2(4):56-61 ISSN-2277-4149 Int. Res J Pharm. App Sci. Vol-II, Issue-IV, Jul-Aug, 2012 56 The antioxidant activity and cytotoxicity methanol extracts from cranberry plants Resmi Mustarichie1*, Zalinar Udin2, Ahmad Muhtadi1, Emma Surahman, Anas Subarnas1 and Supriyatna1. 1 Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia. 2 Indonesian Institute of Sciences, Bandung, Indonesia. (Received: 04 August, 2012; Accepted: 06 August, 2012; Published: 29 August, 2012) *Corresponding Author: Email: email@example.com ABSTRACT The purpose of this study was to determine the total phenol content, antioxidant activity and cytotoxicity of methanol extracts from cranberry plants. The highest total phenol content of 17.1 mg/100 g, and antioxidant activity with IC50 = 23.8 mg/100 g. This situation shows that the total content of phenolic plant extracts examined correlated with DPPH activity. IC50 cytotoxicity of methanol extracts of each 75.11 µg/mL against Calu-6 cells, 177.53 from µg/mL against MCF-cells and 54.87 µg/mL against HCT- 116 cells. From the data obtained we can conclude that this plant has a quite high of total phenolic content and antioxidant activity. Correlation between total phenolics increased DPPH free radical scavenging and cytotoxic activities are quite good. The results of this study showed that cranberry plants can be used as the basis for the treatment of some diseases. Key words: cranberry, methanol extracts, natural antioxidants, total phenolics content, activity of DPPH radical scavenger, cytotoxicity activity INTRODUCTION Experimental study of epidemiology, laboratory animal and human investigations indicate that consumption of fruits and vegetables are associated with lower risk of several diseases including cardiovascular disease and cancer1,2,3,4,5. These beneficial effects have been associated with bioactive properties compounds. Many plants have antioxidant activity and is recommended for consumption6,7. The importance of phenolic compounds, especially flavonoids, are due to their ability to act as a recipient of a highly efficient free radical8,9,10. Therefore, several compounds isothiocyanate (vegetables), carotenoids including alpha-carotene, gamma cryptoxanthin, zeatxanthin, (tomatoes), resveratrol (grapes and wine), ellagic acid (berries Various) , glutathione-S-transferase (garlic), diallyl sulfide (garlic), genestin (soybean), curcumin (turmeric), indole-3-carbinol, inositol, organosulfur compounds, sulforaphane, squalene, and terpenes active in cancer prevention11. Synthetic antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tert-butylhydroquinone (TBHQ), has of natural phenolic as follows: carotene, luttein, beta-lycopene also been widely used in food, however, are known to have few side effects12. Therefore, investigation of new natural resources as an antioxidant to increase the safety13,14, and various types of antioxidants found in various plants, which does not cause a health researched15,16,17. The above-mentioned investigations have shown that increased consumption of fruits and vegetables significantly reduces the incidence of chronic diseases, like cancer, heart disease and other pathologies associated Especially the antioxidant activity of caffeic acid and hydroxycinnamic acid compounds have been studied. Found that the antioxidant activity of these scavenging in the following order: rosmarinic> phenethyl ester of caffeic acid> caffeic acid tocopherol acid> chlorogenic> cidferulic acid> ferulic phenethyl ester> BHT16. This study attempted to determine the total phenolic content, antioxidant cytotoxicity activity of methanol extract of cranberry plants. Cranberries are a group of evergreen dwarf shrubs or trailing vines in the subgenus Oxycoccus of the genus Vaccinium risk for consumers with aging12. activity and Research Article
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Resmi Mustarichie et al. / Int. Res J Pharm. App Sci., 2012; 2(4): 56-61 (Family: Ericaceae). To conduct this research, we use several tests including the Folin-Ciocalteu assay, 1.1-diphenyl-2-picrylhydrazyl free radical scavenging assay (DPPH), and MTT (3 - (4,5-dimethylthiazol-2-yl) - 2.5-diphenyltetrazolium bromide) assay. Free radical scavenging assay, usually intended to determine the mechanism of antioxidants that inhibit lipid oxidation. It is understood that antioxidants, inhibitors of lipid peroxidation is not only important for food protection, but also, it is important for the defense of living cells against oxidative damage1. Generally, the methods used to determine free radical scavenging is 1.1-diphenyl-2-picrylhydrazyl - DPPH assay18,19. Compared with other methods, DPPH method is relatively short18. This study therefore using DPPH test. MATERIALS & METHODS Materials Folin-Ciocalteu reagent, 1.1-diphenyl-2-picrylhydrazyl (DPPH), MTT (3 - (4, 5-dimethylthiazol-2-yl) -2.5-diphenyltetrazolium bromide), butylated hydroxyanisole butylated hydroxytoluene (BHT), ascorbic acid available from Sigma Chemical Co., St. Louis, MO, USA. All reagents, are pro analysis. Methods Samples preparation Plants used were cranberries, including leaves and stems, which when cut into pieces, dried at 50oC for five days. Sample extraction using 95% methanol at room temperature, and the extract obtained was concentrated using evaporators. Methanol extract obtained is then used for each determination of phenolic content, free radical scavenging activity of DPPH, and the cytotoxicity activity. Determination of total phenolic content (TP) Determination of total phenolic content (TP), using Folin-Ciocalteu test20. 5 mL of water, 0.5 to 1.0 mL sample, and 1.0 mL Folin-Ciocalteu reagent put into 25 mL volumetric flask, and left for 5-8 minutes at room temperature. Subsequently, 10 mL 7% sodium carbonate solution were added, and followed by the addition of water until the volume reached 25 mL. Mixture left at room temperature for 2 hours. Then the sample is filtered through a Whatman 0.45 m determination of TP. concentration using spectrophotometer at 640 nm. TP standardized content of ferulic acid and expressed as 100 mg/g ferulic acid (FAE). The range for this linearity test ISSN-2277-4149 Int. Res J Pharm. App Sci. Vol-II, Issue-IV, Jul-Aug, 2012 57 (BHA), before the is determined as 0.5 to 5.0 mg/L FAE (R2 = 0.9990), giving an absorbance range of from 0.050 to 0.555 AU. Determination of Free scavenging Each methanol concentrations (3.1, 6.3, 12.5, 25, and 50 mg/100 g) added to 1.5 × 10-4 M solution of DPPH in methanol and the reaction mixture shaken vigorously. Amount of DPPH which does not react determined at 520 nm, and free radical scavenging aktiviats obtained from the following equation: free radical scavenging activity (%) = ((OD control - OD sample) / control OD)) × 100. The antioxidant activity of plant extracts is expressed as IC50, defined as the concentration (in mg/100g) of the extract required to inhibit the formation of DPPH radicals by 50%. Determination of cytotoxicity Used cell line: Calu-6 (human lung carcinoma), MCF-7 adenocarcinoma), and HCT-116 (human colon carcinoma). Tues grown in RPMI-1640 medium at 37oC, 5% CO2 harvested, and counted (3 × 104 cells/mL), and transferred into 96-well plate and incubated for 24 hours before addition of test compounds. Dilutions of test samples prepared by dissolving compounds in DMSO followed by dilution with RPMI-1640 to give a final concentration of 25, 50, 100, 200, 400, and 800 ug/mL. 90 μL and 10 μL sample cell, incubated for 72 hours and added to solution of MTT (5 mg/mL dissolved in 1 mL of Phosphate Buffer Solution / PBS), a total of 10 μL into each well of 96-well plate as described by Tian et.al21. Well plates were incubated at 37oC for 4 hours. From each well containing media, MTT is not tied and dead cells removed by aspiration, and 150 μL of DMSO added to each well. Then the optical density of samples was determined using ELISA reader at 540 nm Reader. As a positive control used distilled water and DMSO as solvent control. Cytotoxicity obtained by comparing the absorbance between sample and control. Those values are then used to calculate the concentration of extract required to grow 50% decrease (IC50) in the growth of cells. RESULTS AND DISCUSSION Methanol extracts of total phenolic content was 17.1 mg/100g cranberry and total phenolic antioxidant BHT as standard is 1.5 mg/100 g (Figure 1). These results are comparable with the activity of DPPH free radical savenging22. Zhou and Yu23 also reported that total phenolic Radical DPPH extract at various (human breast incubator. Cell
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Resmi Mustarichie et al. / Int. Res J Pharm. App Sci., 2012; 2(4): 56-61 content of vegetable extracts is correlated with the activity of DPPH free radical scavenging, and showed that the amount of phenolics play an important role in the antioxidant activity of plant materials. ISSN-2277-4149 Int. Res J Pharm. App Sci. Vol-II, Issue-IV, Jul-Aug, 2012 58 Figure 1. Total phenolic content of methanol extracts of cranberry and BHT The result of the determination of DPPH radical activity scavengin cranberry plant extracts can be seen in Table 1. As can be seen, the methanol extracts had DPPH radical activity with IC50 value of 23.8 mg/100 g, whereas the activity of DPPH radical scavenging BHT have IC50 11.3 mg/100 g. This indicates that the scavenging activity of plant extracts is lower than the scavenging activity of synthetic antioxidant BHT. Table 1. Antioxidant activity of cranberry methanol extract and BHT Sample Concentrations, mg/100 g 3.1 6.3 Cranberry methanol extract 4.7 12.1 BHT 15.6 33.5 The result of the determination of the cytotoxicity test using three kinds of cell line showed that the methanol extract of cranberry possessed IC50 each values 75.11 g/mL against Calu-6 cells, 177.53 of g/mL against MCF-cells and 54.87 g/mL against HCT-116 cells. (Table 2, Figure 2), whereas IC50 BHT values against all three cell line is 57.05 g/ mL (Calu-6), 57.93 g/ml (MCF-7) and 34.75 g/mL (HCT-116) (Table 2 and Figure 3). 12.5 25 50 IC50 26.5 55.2 52.8 81.3 86.4 92.4 23.8 11.3 Table 2. Cytotoxicity activity of cranberry ethanol extract and BHT using a variety of cell line Figure 2. % cranberry methanol extract viability using cell line MCF-7, Calu-6 and HCT-116 Figure 3. % BHT viability using MCF-7 cell line, Calu-6 and HCT-116 Increased consumption of fruits and vegetables significantly reduces the incidence of chronic diseases, like cancer, heart disease and other pathologies associated with aging Phytochemicals, phenolic compounds, especially natural products is suggested to be the bioactive compounds that have health benefits25. This situation points to the fact that phenolic compounds have antioxidant properties26. As a result, consumption of natural antioxidants is inversely related to several chronic diseases26. Antioxidants can delay or inhibit oxidation of lipids by inhibiting the initiation or propagation of oxidative chain reactions22. The antioxidant activity of phenolic compounds, mainly due to the nature of these redox compounds, which can play an important role in 12,24. Sample IC50 ( g/mL) Calu-6 MCF-7 HCT-116 Cranberry methanol extract BHT 75.11 57.05 177.53 57.93 54.87 34.75
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Resmi Mustarichie et al. / Int. Res J Pharm. App Sci., 2012; 2(4): 56-61 absorbing and neutralizing free radicals, quenching singlet and triplet oxygen, or peroxide27. From this study the methanol extract of cranberry is also known to have radical scavenging activity of high DPPH (IC50 = 23.8 mg/100 g), this shows that the DPPH radical scavenging depends on the content and strong relationships between phenolics total content and activity level radical scavenging. This data is also supported by the results of research that has been reported by Lee et al.6 who showed that extracts China traditional plants in addition to having a high total phenolic also has high scavenging DPPH radical activity. Cai et al.13 studied the content of phenolic compounds, antioxidant and anticancer activity of the 112 plant species from 50 families of traditional Chinese medicine plant, using a systematic method of extracts of the ABTS (2, 2-azinobis (3-ethylbenzthiazoline Acid-6-sulfonic acid) against drug crops. They found that TEAC (Trolox equivalent antioxidant capacity) values and total phenolic content for methanolic extracts of plants ranged from 46.7 to 17 323 Trolox equivalent (TE) / 100 g DW (dry weight) and from 0.22 to 50.3 g of gallic acid equivalent (GAE)/100 g DW. Significant positive linear relationship between antioxidant activity and total phenolic content (R2 = 0.95 all) showed that the antioxidant phenolic compounds are the dominant components in the tested herbs. Major types of phenolic compounds from most plants tested were phenolic acids, flavonoids, tannins, coumarins, lignans, quinones, stilbenes, and curcuminoids. TEAC and phenolic content of 32 spice extracts from 21 botanical families growing in Poland have also been investigated26 and found that the total phenol content ranged from 0.07 to 15.2 mg GAE / 100 g DW. Similar analytical methods used for determination of total phenolics and free radical ABTS method also cited in the report. Phenolic acid compounds identified in the species being analyzed are caffeic, coumaric , ferulic and neochlorogenic, while the dominant compounds are flavonoids quercetin, luteolin, apigenin, kaempferol and isorhamnetin. Myricetin detected only in Epilobium hirsutum L. As indicated, this report also found that most of the spices studied have high levels of phenolics and also having high antioxidant activity. Dastmalchi et al.29 in his research using the materials collected Moldavian balm from Iran. For the extraction of bioactive compounds used in seven solvents with different polarity (petroleum ether, dichloromethane, acetonitrile, ethyl acetate, methanol, n- butanol and water). The identification results show that hydroxylated cinnamic acid, and its derivatives ISSN-2277-4149 Int. Res J Pharm. App Sci. Vol-II, Issue-IV, Jul-Aug, 2012 59 and flavonoids found in the extract, rosmarinic acid is a component of the most widely identified. Our results also showed that the association of high levels of phenolics with high antioxidant activity which affects anticancer activity of the plants studied. Methanol extract of cranberry in addition to having a high antioxidant ativities (IC50 = 23.8 mg/100 g) also have high anticancer activity against HCT-116 cells (IC50 = 54.87 g/mL). Cai et al.13 stated that the prevention and treatment of cancer by using traditional Chinese medicines has risen high enough. Herbal medicine known to have high antioxidant activity and phenolic levels are significantly higher than vegetables and fruits. They concluded that the traditional Chinese medicinal plants associated with anticancer may have a potential source of natural antioxidants and can be beneficial chemopreventive compounds. Manosroi et al.30 reported on the anti-proliferative activity of essential oil from 17 Thai medicinal plants against leukemia epidermal carcinoma cell line (KB) and murine cell line (P338) using the MTT assay. The results showed that the leaves and oil of Sweet Basil Guava (Psidium guajava L.) has an anti-proliferative activity against cell line KB and P388. Cho and Leung14 has been studied in vitro and in vivo anti-tumor effects membranaceus (Fisch.) Bunge, commonly used as a medicinal plant of China, and proved able to restore T cell dysfunction in cancer patients. Of the five bioactive fractions membranaceus root, it is known that the fraction of AI (methanol fraction) is the best fraction of the five factions in connection with mitogenicity on murine splenocytes. Besides investigating the cytostatic effects of AI, activity on macrophage function, tumor necrosis factor production, induction of lymphokine-activated killer cells and tumor cell differentiation was also examined. Tumor macrophages and myeloid tumors found more sensitive to the cytostatic activity of the AI, whereas tumor fibroblasts and mouse Ehrlich ascites tumor seems relatively resistant. In addition, AI can effectively suppress the growth of syngeneic tumors in mice in vivo. The results showed that murine dipertreatmen with AI can increase the cytostatic activity of MBL-2 tumor in vitro and in vivo. Preincubation of mouse splenocytes with AI can induce activity in vitro lymphokine-activated on the cell line WEHI-164. In addition, the AI is able to induce the differentiation of both human monocytic cells and murine in vitro. AI can even restore the depressed mitogenic response in mice in vivo. Can be concluded that Astragalus of Astragalus isolated from A. macrophages that
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Resmi Mustarichie et al. / Int. Res J Pharm. App Sci., 2012; 2(4): 56-61 membranaceus can play both in vitro and in vivo anti-tumor effects, by activating anti-tumor immune mechanism for host. All the above results support the results of research conducted today is that cranberry plants extracted by methanol have antioxidant properties associated with anti-tumor properties. CONCLUSIONS Cranberry plants studied contain relatively high total phenolics and antioxidant activity. DPPH free radical scavenging activity increased with increasing levels of phenolics in cranberry extract. These results strongly suggested that cranberry plants extract is promising sources for total phenolics and antioxidant agents and can be used in addition to basic drugs in the treatment of some diseases. As for anticancer plant investigations such as components responsible for such activity, toxicity, and anti proliferations tests to cell-lines are required . REFERENCES 1. Barbaste, M., Berke´e B., Dumas, M., Soulet, S., Delaunay, Castagnino, Arnaudinaud, V., Che`eze, C. and Vercauteren, antioxidants, peroxidation cardiovascular risks. J Nutr Health Aging , 2002, 6: 209–223. 2. Block,G., Patterson, B. and Subar, A.. Fruits, vegetables, prevention: a review epidemiological evidence. Nutr Cancer, 1992, 18: 1–29. 3. Gorinstein, S., Leontowicz, Leontowicz, M., Drzewiecki, Jastrzebski, Z., Tapia, M.S., Katrich, E. and Trakhtenberg, S. Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels antioxidant activity in cholesterol-containing and cholesterol-free diets. Life Sci, 2005, 77: 2384–2397. 4. Gorinstein, S., Caspi, A., Libman, I., Lerner, Z.H., Huang, D., Leontowicz, H., Leontowicz, M., Tashma, Z., Katrich, E. and Trakhtenberg, S. Red grapefruit positively influences serum triglyceride level in patients suffering from coronary athereosclerosis: studies in vitro and in humans. J Agric Food Chem, 2006, 54: 1887–1892. ISSN-2277-4149 Int. Res J Pharm. App Sci. Vol-II, Issue-IV, Jul-Aug, 2012 60 further J.-C.L., J. Dietary and and cancer the of H., J., and plasma rats fed 5. Steinmetz, K.A. and Potter, J.D. Vegetables, fruit, Epidemiol Cancer Causes Contr, 1991, 2: 325–357. 6. Lee, S.E., Hwang, H.J., Ha, J.S., Ha, H.S., Jeong, H.S. and Kim, J.H. Screening of medicinal plant extracts for antioxidant activity. Life Sci, 2003, 73: 167–179. 7. Tiwari, A.K. Imbalance in antioxidant defense and Multiapproach of natural antioxidant therapy. Current Sci, 2001, 8: 1179-1187. 8. Langley-Evans,S.C. potential of green and black tea determined using the ferric reducing power (FRAP) assay. Inter J Food Sci Nutr , 2000, 51: 181–188. 9. Paganga, G., Miller, N. and Rice-Evans, C.A. The polyphenol content of fruit and vegetables antioxidant activities. What does a serving constitute. Free Rad Res, 1999, 30: 153–162. 10. Vinson, J.A., Su, X., Zubic, L. and Bose, P. Phenol antioxidant quantity and quality of foods: fruits. J Agric Food Chem, 2001, 49: 5315–5321. 11. Wattenberg, L.W. Chemoprevention of carcinogenesis by constituents: Symposium introduction. Pharm Biol, 1998, 36: 6–7 (suppl.). 12. Russo, G.L. Ins and outs of dietary phytochemicals chemoprevention. Biochem Pharmacol, 2007, 74: 533–544. 13. Cai, Y.,Luo, O., Sun, M. and Corke, H. Antioxidant activity compounds of 112 traditional Chinese medicinal plants anticancer. Life Sci, 2004, 74: 2157–2184. 14. Cho, W.C.S. and Leung, K.N. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Letters, 2007, 252: 43–54. 15. Larson, R.A. The antioxidants of higher plants. Phytochem, 1988, 27: 969–978. 16. Wanasundara, P.K.J.P.D., Shahidi, F. and Shukla, V.K.S. Endogenous antioxidants from noilseeds and edible oils. Food Rev Inter, 1997, 13: 225–292. 17. Wanasundara, U.N. and Shahidi, F. Canola extracts as an alternative natural antioxidant for canola oil. J Am Oil Chem Soc, 1994, 71: 817–822. 18. Brand-Williams, W., Cuvelier M.E. and Berset, C. Use of free radical method to and cancer. J human diseases: Antioxidant and their minor dietary in cancer and phenolic associated with Cancer
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Resmi Mustarichie et al. / Int. Res J Pharm. App Sci., 2012; 2(4): 56-61 evaluate antioxidant activity. Food Sci Technol (London) , 1995, 28: 25–30. 19. Wang, L.-F and Zhang, H.-Y. A theoretical investigation on DPPH radical- scavenging mechanism of edaravone. Bioorg Med Chem Letters, 2003, 13: 3789–3792. 20. Singleton, V.L. and Rossi, J.A. A colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents, Am J Enol Vitic, 1965, 16, 144–158. 21. Tian, Q., Miller, E.G., Ahmad, H., Tang, L. and Patil, B.S. Differential inhibition of human proliferation by citrus limonoids, Nutr Cancer, 2001, 40: 180–184. 22. Velioglu, Y.S., Mazza, G., Gao, L. and Oomah, B.D. Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. J Agric Food Chem, 1998, 46: 4113–4117. 23. Zhou, K. and Yu, L. Total phenolic contents and antioxidant properties of commonly consumed vegetables grown in Colorado. LWT, 2006, 39: 1155-1162. 24. Serafini, M., Bellocco, R., Wolk, A. and Ekstrom, A.M. Total antioxidant potential of fruit and vegetables and risk of gastric cancer.Gastroenterol, 2002, 123: 85–99. 25. Sun, J., Chu, Y.F., Wu, X.Z. and R.H. Liu, R.H. Antioxidant proliferative activities of common fruits. J Agric Food Chem, 2002, 50, 7449–7454. 26. Joshipura, K.J., Hu, F.B., Manson, J.E., Stampfer, M.J., Rimm, B.E., Speizer, F.E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D. and Willett, W.C. The effect of fruit and vegetable intake on risk for coronary heart disease, Ann Intern Med, 2001, 134: 1106–1114. 27. Javanmardia, J., Stushnoff, C., Lockeb, E. and Vivancob, J.M. Antioxidant activity and total phenolic content of Iranian Ocimum accessions, Food Chem, 2003, 83: 547–550. 28. Wojdyło, Oszmian´nski, Czemerys, R. Antioxidant activity and phenolic compounds in 32 selected herbs, Food Chem, 2007, 105: 940–949. 29. Dastmalchi, K. and Damien-Dorman, H.J., Laakso, I. and Hiltunen, R. Chemical composition and antioxidative activity of Moldavian (Dracocephalum moldavica L), extracts ISSN-2277-4149 Int. Res J Pharm. App Sci. Vol-II, Issue-IV, Jul-Aug, 2012 61 cancer cell and anti J. and balm Food Sci Technol, 2007, 40: 1664–1669. 30. Manosroi, J.P., Dhumtanom, A. and Manosroi, A. Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P338 cell lines, Cancer Letters, 2006, 235: 114–120.
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Adam Bien: MONITORING GLASSFISH WITH JAVA8 AND NASHORN
GlassFish emits JSON monitoring data over HTTP. Java 8 comes with JavaScript "Nashorn" engine with shell scripting support. JSON stands for "JavaScript Object Notation" and is easily accessible from JavaScript: [see code]... ... Output is (hopefully): 0 rollbacks. The script above can be easily extended to monitor different aspects: from http, over JDBC connection pools, to even application specific performance metrics. See also...
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Palladium / White Sapphire
Palladium / Pink Sapphire / London Blue Topaz
Palladium / White Sapphire
Palladium / Blue Sapphire / Aquamarine
Palladium / Blue Sapphire
Palladium / Yellow Sapphire
Palladium / Blue Sapphire
Palladium / Pink Sapphire / Blue Topaz
Palladium / Blue Sapphire / Aquamarine
Palladium / Yellow Sapphire / White Sapphire
Earrings are the essential finishing touch to everything you wear. At Gemvara, we believe that your earrings should be as unique as you. All our stylish earrings are made to order in your choice of gems and precious metals. Choose Diamond and Palladium or Rock Crystal and Platinum: it's your choice. Mix and match gems and precious metals for a look that's exactly you. Gemvara uses only the highest quality materials to craft your Palladium Sapphire Gemstone Earrings with meticulous attention to detail. Our precious metals are recycled or responsibly mined. Palladium is the newest precious metal. A platinum group metal, palladium is rare, lustrous, and naturally white.Our wide selection of Palladium Sapphire Gemstone Earrings by talented designers means you can find earrings that are exactly your style. You can choose your favorite earring backs too. Gemvara's fine quality Palladium Sapphire Gemstone Earrings are designed to be passed down for generations to come, crafted by hand in the United States.
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Club Ex FitnessRead MoreThe team at Clubex Fitness & Nutrition believes that when it comes to diet and exercise, success is a team effort. Thankfully, the trainers host about 30 different group exercise classes every week, ranging from spinning, kickboxing, and Zumba to a Kick Your Butt boot camp. Those looking for a more specialized approach can work one-on-one with personal trainers that help clients design custom exercise plans. Of course, the facility also allows for clients to exercise on their own. Clubex makes solo workouts easy with its more than 75 pieces of cardio equipment, more than 100 pieces of strength equipment, and about 10 tons of free weights, which keep the gym from blowing away during storms. And if that lengthy list of equipment isn't enough, Clubex also offers boxing and karate rooms, basketball and racquetball courts, and even an outdoor obstacle course that doubles as an auto shop in case you need new tires. Onsite babysitting makes it even easier to enjoy a productive workout, and afterward clients can refuel at the facility's full-service juice bar.649 Oak St.East Bridgewater, MA US
Silverlake FitnessRead MoreMake yourself a member at Silverlake Fitness in Halifax, and enjoy working out at a spot you'll love. For a well-crafted dish, be sure to visit the restaurant at this gym. This gym is kid-friendly, so little ones are welcome to tag along. Personal trainers are also available for one-on-one fitness coaching and assessments. Combining self-defense techniques with high-intensity cardio, these kickboxing classes offer the ultimate full-body workout. Embark on a cross fit challenge. It'll transform your body, and you'll love your new-found definition. Parking is plentiful, so guests can feel free to bring their vehicles.430 Plymouth StHalifax, MA US
Filedheacht Music SchoolRead MoreThe troubadours at Filedheacht Music School imbue students with the skills and self-confidence to let their inner music out as part of solo or ensemble performances. Offering private instruction in voice, guitar, brass, and woodwind instruments, Filedheacht helps aspiring musicians of all ages practice their arts as part of a supportive, instructive community. The school hosts an annual concert each June, along with a year-round rotation of choirs, glee clubs, rock ensembles, flute choirs, and competitive screaming matches.301 Central St (P. O. Box 388)East Bridgewater, MA US
Get In Shape For Women AbingtonRead MoreYou're on your way to a better workout when you join Bridgewater's Get In Shape For Women. With food just the way you like it, this gym elevates your restaurant experience just on the level of taste. These kickboxing classes bring fitness to a whole new level, leaving you feeling and looking your best. Fitness is an incredibly difficult journey, so make it easier by exploring the personal training services offered here. Cross fit burns calories like no other routines. Parking is plentiful, so visitors can feel free to bring their vehicles.180 Winter St.Bridgewater, MA US
Just For You Personal TrainingRead MoreThe trainers at Just For You Personal Training delve into their arsenal of techniques to get clients in shape during personal training and group training classes. They can customize a workout program to each client's specific needs, drawing from exercises that include disciplines such as kickboxing, weightlifting, functional cardio, core stability, dynamic flexibility, plyometrics, and foam rolling. Trainers also reveal nutritional secrets to clients to help them eat right, choose healthy foods, and abide by their necessary calorie requirements.319 Plymouth StHalifax, MA US
CurvesRead MoreJump on the treadmill or work on your weights — Bridgewater's Curves offers a full body workout. Intensity is key to realizing your fitness dreams. With the rigor of a cross fit workout, intensity won't be a problem. These cardio kickboxing classes feature a wide range of techniques to help you strengthen your body. Create a team around you to help support your fitness goals. That's why their personal trainers could be the perfect fit for you. Parking is plentiful, so visitors can feel free to bring their vehicles.47 Broad StreetBridgewater, MA US


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HP Setup Assistant unable to configure wireless network for HP 3520; Mac OS 10.6.8[ Edited ]
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10-05-2012 09:09 PM - edited 10-05-2012 09:12 PM
I just got an HP 3520 all-in-one and am trying to get it connected to my home network. The HP Auto Wireless Network Setup wizard is apparently unable to communicate with the printer, although my Mac and the printer are not more than 2 feet apart. And yes, the wizard *is* identifying the correct network and password. So then it suggests that I connect the USB cable and try again. When I do that, it says "The software was unable to configure your device", and gives a little report of IP address, Address Mode, etc., all of which say "Failed to retrieve network". Help!
Sorry, I forgot to mention that I can print just fine using the USB cable, but I want *all* our computers (especially my wife's!!) to be able to print, which is why I bought a wireless printer to begin with.
- HP Printers - Printer Does Not Maintain Wireless Connection
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Free Dailymotion Video Downloader1.0
editor's review
Free Dailymotion Video Downloader is a handy and easy to use software solution whose main purpose is to help you save your favorite videos from the web to your computer, so you can watch them whenever you want, regardless of your Internet access.
Watch out during installation
During the installation process, you should pay attention to what you click 'Next', as the utility will offer to also install third party applications that is does not need in order to function.
As such, you can decide whether to accept or decline the offer, after which the operation will undergo as normal, allowing you to start working with Free Dailymotion Video Downloader in just moments.
A common yet practical interface
The general appearance of program is fairly similar to many other video grabbing tools, so you will experience no difficulty in figuring out how to work with it.
The 'Add URL' field will instantly display the link you have copied in your clipboard, while the 'Add Bulk URL' function enables you to paste multiple links and save them to your PC simultaneously.
Download DailyMotion videos with just a few button presses
To grab a video from DailyMotion, you need to copy the corresponding address from your web browser and the utility will automatically paste it in the proper field, allowing you to add it to the queue.
Before proceeding, you have the possibility of choosing a preferred destination folder, after which you can click on the 'Download Selected' button to start saving the video to your computer. However, you cannot opt for a specific format or preview the file, the extent of permitted user customization limiting itself to the file path.
A simple online video grabber
In summary, Free Dailymotion Video Downloader is a useful and efficient program that was created to assist you in obtaining your favorite movies from DailyMotion, with little to no effort entailed for you.
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Middle East recruiters expect new jobs in next 6 months
Naukrigulf survey reveals job creation and hiring much better in 2015 compared with 2014October 13, 2015 10:17
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The capacity of the project is little changed at more than 400,000 tonnes per year of carbon black, rubber and synthetic polymers for domestic and international sales.
March 1, 2011 11:40 by Reuters
Saudi Basic Industries Corp (SABIC) said on Tuesday it would build only one rubber plant project, in Jubail on Saudi Arabia's Gulf coast, instead of two as originally planned.
When SABIC and Exxon Mobil Chemical first announced the rubber project, they said the expansion would include the Kemya joint venture between the two companies and their other venture, Yanpet, which is based in Yanbu on the Red Sea coast.
But SABIC said in a bourse statement it would go ahead with only one of those ventures, since the Jubail location provides better synergies with the Kemya petrochemical facility.
The capacity of the project is little changed at more than 400,000 tonnes per year of carbon black, rubber and synthetic polymers for domestic and international sales.
SABIC said work on the detailed engineering designs had reached an advanced stage. It did not say what the cost of the project would be, although an executive from Exxon Mobil Chemical had said it would cost $5 billion.
(Reporting by Reem Shamseddine; Editing by David Holmes)


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On Thursday, December 10th, the AAI will host an Airline Roundtable, where experts in antitrust and regulation from government, industry, advocacy, and academia will discuss major competition enforcement and policy issues facing the airline industry.
Latest News
The American Antitrust Institute (AAI) has announced its selection of leading legal practitioners and economists to be recognized at the AAI 2015 Antitrust Enforcement Awards. The top Award and recognition of all finalists and honorable mentions will be featured at a gala awards dinner on Wednesday, November 18, 2015 following the AAI's Annual Private Antitrust Enforcement Conference. Registration and program information for the conference and the awards dinner is available here.
On Wednesday, November 18, 2015, the American Antitrust Institute will host its 9th Annual Private Antitrust Enforcement Conference at the National Press Club in Washington D.C. Following the conference, the AAI will host its 3rd Annual Antitrust Enfor
The American Antitrust Institute (AAI) has filed an amicus brief urging the Third Circuit Court of Appeals to follow a recent decision of the Second Circuit and hold that "product hopping" by brand-name drug manufacturers is not immune from antitrust r
The AAI's analysis on beer mergers and other competition issues can be found below. These resources provide insight into beer markets, previous mergers, and regulatory issues that are helpful in evaluating consolidation proposals.


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Tuesday Twaddle: "Offloading" brands, and the old spinning cone
When is it time for a winery to "offload" underperforming brands?
It happens. You've had a line, or SKU, in the market for years, but for some reason, it's never gained traction. So the hard decision must be faced: Is it time to pull the plug on Grandma?
This is the situation Treasury Wine Estates is facing. The Australian company, which lost more than $100 million in 2013-2014, has brands "that [are] not a priority and may be retired [or] offloaded," according the industry publication, The Drinks Business.
This can never be an easy decision for a big company like TWE. Companies love all their brands, the same way parents love all their children. You can't throw an underperforming child under the bus, of course, but companies aren't families, they're business; and sometimes, "retiring non-priority brands", or repurposing them in some way, is the only way to stay healthy.
* * *
Does this shock you? It shocks me. "One in four bottles of Californian Pinot Noir and Chardonnay have been through the industrial alcohol removal process supplied by ConeTech in the past year." That's another report by The Drinks Business, which adds that the spinning-cone process of lowering the alcohol content of wine is more popular than ever because "winemakers would rather take out alcohol from a ripe wine than risk creating lighter, possibly greener wines from harvesting earlier for naturally lower abvs."
Well, as Dana Carvey's character, The Church Lady, used to say on Saturday Night Live, Isn't that special?
I've written before that I don't mind some technological intervention to produce sound, clean, drinkable wines. These are what Americans want. Critics denounce them as Franken-wines, but to me, that just seems derogatory and mean. Besides, the truth is, since this de-alcoholization is done secretly, no one can ever know just which wines have passed through the spinning cone, so before you give such a wine 96 points and then have to appear foolish when someone outs you, restrain thy criticism.
However, I will venture to say that winemakers are resorting to this somewhat risky procedure because the public drumbeat against higher-alcohol wines has reached such a fever pitch that they feel they have no choice. Many of them, themselves, probably hate themselves for doing it—for giving in. Some of them may be under orders to do it, by the people who sign their paychecks. It's hard for me to believe that any winemaker willingly and happily sends her wine to the spinning cone.
Speaking of those "greener wines" that are the potential result of picking early—which is the natural way to produce lower-alcohol wines—I've tasted some of them at big Pinot Noir tastings, and they're dreadful. Well, I suppose if you like dried oregano, mint and green tomatoes, they're all right, but if you prefer cherries and raspberries (which I do), you'll be disappointed.
Thus we find ourselves staring directly at the schizophrenia running through our modern California wine business. The bullet quote in The Drinks Business article is this: "The consumer preference is for riper style wines, with juicy fruit, but consumers want this with more moderate alcohol levels." Someone should politely tell consumers you can't get ripe fruit without high brix, which in turn translates into healthy alcohol.
But that's not a message that consumers want to hear, and so producers—caught between the proverbial rock and a hard place—increasingly are turning to the spinning cone. And if California goes back to a series of warm vintages, like we used to have, we'll see even more wines spun out.
My thoughts on the S.F. Chronicle's Top 100 Wines of 2014
Of the San Francisco Chronicle's Top 100 Wines of 2014,
- 9 of the 12 Chardonnays have alcohol below 14%
- 13 of 16 Other Whites have alcohol below 14%
- 8 of 9 Sparkling Wine, Rose and Others have alcohol below 14%
- 18 of 23 Pinot Noirs have alcohol below 14%
Did these wines make the cut because they really are the "top" wines of the vintage, or because the alcohol is low, which is where Wine Editor Jon Bonné prefers it to be?
Jon did select numerous Cabernet Sauvignons, red Rhone-style wines, Zinfandels and Other Reds that have well above 14% alcohol, but I suppose that's because he had to include those varieties on his list, and for the most part, those grapes just don't make good wine unless the brix is elevated enough to produce wines in the 14%s and even approaching if not exceeding 15%.
I'm simply puzzled. There are so many great Pinots and Chardonnays out there that don't fit Jon's restricted mold. And what's up with that Calera 2012 Central Coast Pinot that made the list? At 14.6%, it's easily the highest-alcohol Pinot of Jon's bunch, but it certainly isn't a Top 100 Wine of the year. I reviewed it last March 1, just a week before leaving my job at Wine Enthusiast, and gave it 86 points. It's just what you'd expect: Not Josh Jensen's top Pinot, not anywhere close to it, but his least expensive ($26), a nice everyday sipper that's a blend of multiple vineyards along the Central Coast. (I think Josh must be praising the Gods of Caprice for that one!)
Haven't we ridden this low-alcohol train about as far as it can usefully take us? There's something fundamentally mashugana about it. I use the word "mashugana," which is of Yiddish origin, deliberately, for in my version of street parlance, it means, not just "crazy," but nonsensical. For it's nonsensical to demand that California wine be picked underripe, just to satisfy the intellectual inclinations of a small band of adherents.
Jon himself seems not to sense the inconsistencies in his approach. In his introduction to the Top 100 article (after mentioning he'd hung out recently with Steven Spurrier), he tells us that, back in 1976, California wine "was as good as French" (a fact obvious to anyone after Cali wine swept the Paris Tasting). Then he adds that, whilst in London, "Our [i.e. California's] wine promise was again unmistakable." In fact, repeating a theme he's held for some years, he trumpets "This is a golden moment for American wine," which presumably means California wine, or certainly West Coast wine, "which is the scope of our annual Top 100 Wines."
Well, if California wine was great 38 years ago, and has been in a "golden moment" for the few years that Jon's been praising it, are we then to assume that between 1977 and 2008 or 2009, California wine was bad, unbalanced, irregular? I don't think any credible person could claim that. Certainly our wines are wonderful now (the best really are world class), but they were wonderful in the 1970s and 1980s (when I started paying attention to them) and they were wonderful in the 1990s and 2000s (when I was paid to review them). They were wonderful through the second week of March of this year, when I left my old job, and they're wonderful now, although I will confess I no longer taste as widely as I used to nor as broadly as Jon. But how much can have changed since last March? I would say California is in a golden century, not just a moment.
It takes, I think, a special form of mental jujitsu to dismiss higher-alcohol California wine, as Jon does, and then to come out with a statement like "Eight years ago, it would have been hard to imagine a wine like the 2013 Lo-Fi Cabernet Franc," a wine that made Jon's list. Well, it took me all of 40 seconds to go to my database and find Jonata's 2007 El Alma de Jonata Red, a wine that is largely Cabernet Franc. I gave it 96 points, and while I don't know precisely what the alcohol was, I really don't care, either. And how about Lang & Reed? Great Cab Franc house, and has been for years. I could also mention Merryvale, Pride Mountain, Jarvis (both the estate grown and Will Jarvis' Science Project), Peju, Constant and La Jota. All great Cab Francs. There was a Niebaum-Coppola 2002 Cabernet Franc that was so good, I still remember it. But perhaps Jon never tried it; he only arrived at the Chronicle in 2006.
I don't mean to pick on Jon or anybody else. Shortly after he came to the Chronicle, I invited him to dinner, because I thought we Bay Area geeks should all be friends. He's a perfectly nice guy. But I just don't get this addiction to below 14% wines. Blind tasting clearly is the way to figure out what's really going on—just ask Raj Parr and Adam Lee, if you know what I mean and I think most of you do. (Hint: World of Pinot Noir, 2011.)
If the Chron's tasting panel really were tasting blind, their list wouldn't be so heavy on the under-14% wines. It's just not fair to be so harsh against all the others. I thought critics weren't supposed to let their personal preferences affect their reviews. Have times changed?
My Pinot Noir event in Los Angeles
I did my first big event for Jackson Family Wines yesterday, and I think it went pretty well. Despite a downpour, we had a full house. It was on the wines of the Santa Maria Valley, especially Pinot. I didn't want it to be a JFW thing, so I asked my dear friends Dieter Cronje, from Presqu'ile, Chris Hammell, from Bien Nacido, Dick Dore, from Foxen, and James Ontiveros, from Native9 and Alta Maria, to participate, along with Denise Shurtleff (Cambria) and Jonathan Nagy (Byron).
Everybody did such a great job; I'm so proud of them. The idea was to give gatekeepers—somms, bloggers, writers, restaurateurs, merchants—a better idea of what the Santa Maria Valley is because, frankly, in my opinion, people don't fully understand it. That's because it's fairly isolated and hard to get to, without great restaurants or hotels, and the valley floor is more about row crops than winegrapes. But, oh, the terroir is perfect on the benches and hillsides for Pinot Noir, Chardonnay, Syrah and other cool-climate varieties, as our tasting amply demonstrated.
The temperature warms up a degree or two with every mile you go inland in this west-east-running valley (courtesy of the transverse deforming action of the San Andreas Fault), so it was fascinating to taste the Pinot from the westernmost area, Presqu'ile, compared to the Pinot from the easternmost area, Byron, and everything inbetween. Sometimes, data actually verify hunches, and in this case, the data beautifully illustrate this temperature gradient. Check it out, from west [cool] to east [warmer]:
Presqu'ile [westernmost]: alc. 13.2%
Fermentation: 100% whole cluster
Native9 [very western]: alc. 13.5%
Fermentation; 100% whole cluster
Bien Nacido (central): alc. 13.7%
Fermentation: partial whole cluster
Foxen Julia's Vineyard (toward the east): alc. 14.2%
Fermentation: 100% destemmed
Cambria (toward the east): alc. 14.6%
Fermentation: 100% destemmed
Byron (easternmost, warmest): alc. 14.4%
Fermentation: 100% destemmed
Alcohols go up as you travel to warmer inland areas. As for the fermentation, the Presqu'ile and Native9 winemakers felt the wines could benefit from the added tannins and body of stems, whereas the inland winemakers felt their wines were full-bodied and tannic enough to not need stems. Right in the middle is Bien Nacido, where you get partial whole cluster.
Isn't that pretty? Such a sweet illustration of the way climate impacts winemaking decisions. And yet all the wines, in my opinion, showed a distinct Santa Maria Valley character: Spicy. Silky tannins. Great fruit, running towards the red: pomegranates, cherries. Great balance and complexity, as well as dryness. And great ageability. Afterwards, we had a library tasting, and the oldest bottlings, dating to 1997, were superb, among the best California Pinot Noirs I've ever had.
I ran into a few diehard somms who would never sell anything in their restaurants besides Burgundy, and that's just fine, it's a free world. But really, this was a sensational tasting, one of the best I ever went to. I wish you could have been there. We had it at Republique restaurant, on La Brea in L.A., which is on the site of the old Campanile, a restaurant I enjoyed ages ago. Chef Walter Manzke prepared some small plates to enjoy with the older wines, and that food was uncannily good. I'm still thinking about it.
Afterwards a group of somms and I hung out in the front of the restaurant, talking about cocktails. I do like a good vodka gimlet. But I have to say, in all sincerity, these Santa Maria Valley Pinots are awesome, from a cru as great as any in California, even if it doesn't get the love of Santa Rita Hills or Russian River Valley. Maybe it will now start to.
See you tomorrow!
Terroir in Pinot Noir: an approach, and a problem
When it comes to coastal California Pinot Noir, we make much of the distinctions of terroir ("we" being the wine media, some winemakers and everyone else involved in this rather arcane conversation).
We know the regions we celebrate: Russian River Valley, Sonoma Coast, Carneros, Anderson Valley, Santa Cruz Mountains, Monterey County, San Luis Obispo, Santa Maria Valley, Santa Rita Hills and so on. We say (and may actually believe) that each region is unique. If this were not the case, then what difference would an appellation of origin make, anyway? If each of these regions is not truly different, the only thing we'd concern ourselves with would be the reputation of the winery and the quality of the wine.
But of course they're different. Aren't they? Anyone classically educated in Burgundy understands that Chambolle-Musigny is "feminine, elegant," Vosne-Romanée "deep, rich, velvety but not heavy." Gevrey-Chambertin is "masculine, complex and long-lasting;" Echézeaux "close-knit and elegant." (Descriptions are from Michael Broadbent.) To expect anyone who loves California wine not to transfer these templates to California—in Californian-ese–is, frankly, magical thinking.
And so we insist that the Pinot Noirs (and Cabernets, and Zinfandels, and Chardonnays, and so on) from our different AVAs must be different; and, when we discover (if we do) that they indeed are, we feel content and justified. To discover that the world is the way you expect it to be, is a verification of our moral and intellectual good judgment. Life is good, when you can make sense of it according to your own terms. Without that sense-making, life turns disturbingly chaotic.
And yet, anyone who's been around for a while will tell you that, when it comes to California wine, things aren't that simple. It is not always possible to tell an Arroyo Grande Valley Pinot Noir from a Santa Lucia Highlands Pinot Noir, nor for that matter to tell a northern SLH Pinot (Morgan) from a southern one (Pisoni), as has historically been the case for the two Côtes, de Noirs and Beaune. As our grapes get picked riper than they used to, and vintages become warmer, regional distinctions become blurred. (This isn't to say that picking early is a guarantee of terroir.) It may also be that the much-touted Dijon clones contribute a certain sameness to Pinot Noir. And there's a standardization of winemaking technique (cold soaking the grapes, new French oak) that also covers or can mask terroir. It can be very difficult even for trained winemakers to discern their own wines in blind tastings—or even to agree on what characteristics their own terroir displays!
Terroir, then, is a conundrum, a paradox. In one sense, it's a bunch of hokum. In another, common sense tells us it has got to be true. Are grapes not like humans? Someone from the Louisiana Bayou country is going to be a lot different than someone from the South Bronx (me). Where we were born and grew up puts an indelible stamp on us; no matter how much we might subsequently change, our upbringing never leaves us. This is the terroir of humans.
One could prove the truth of wine terroir and end all the discussions forever the following way: You could organize a blind tasting of all the experts. Give them flights of Pinot Noirs, from all of California's major coastal regions, and ask them to come up with descriptors. Correlate all the findings in a statistically meaningful way. If there is such a thing as terroir, you should be able to tweak out reliable and consistent characteristics from each region. Then repeat the experiment for the next ten years.
But you can see that this is clearly impossible, on practical grounds, if no other; and whatever the conclusions, reputable people would object, and we would have to factor in their objections. We are therefore faced with the limitations of theory. Here, a few quotes are apt:
If the facts don't fit the theory, change the facts.
Albert Einstein
The moment a person forms a theory, his imagination sees in every object only the traits which favor that theory.
Thomas Jefferson
The next quote isn't specifically about theory, but it does say a lot about how Californians like to break society's theories:
I moved to California because it's a lot freer, you know? You can do what you want to do, and nobody bugs you.
Janis Joplin
And my favorite:
Before I got married I had six theories about raising children; now, I have six children and no theories.
John Wilmot
I'm working on a project where we're trying to figure out what makes Santa Maria Valley Pinot Noir different and distinct from all other coastal California appellations. I think, in my bones, that it is; I believe I've noted those differences, over the course of many years, and can describe them, even if I can't explain them; and I know for damn sure that the Santa Maria Valley is utterly unlike any other coastal growing region, in climate but perhaps even more in earth. Every fiber in me insists that there's a Santa Maria character to Pinot Noir. At the same time, for all this certainty, I know the enormity of the challenge in nailing it. Wish me luck.
A visit to an old-new winery in Carneros
I'm in Carneros today, visiting one of Jackson Family Wines' newest estates, Carneros Hills, on the site the former Buena Vista vineyard and production facility on Ramal Road, on the Sonoma County side of that sprawling appellation, just over the Napa line.
Well do I remember the acclaim and hope that greeted Carneros's emergence as an appellation on the wine scene. Los Carneros (the proper name) wasn't declared an American Viticultural Area until relatively late, 1987,* by which time its neighbors—Napa Valley, Sonoma Valley, even little Suisun Valley and Solano County Green Valley—already were AVAs. Why it took Carneros so long, I don't know; perhaps it was because it crossed county lines, which was something the TTB hadn't encountered before. It's not as if Carneros was a new place to grow grapes: the Carneros Quality Alliance says wine grapes were first planted there in the late 1830s, and by the 1870s, the first winery had been built.
With the formal creation of the Carneros AVA, the wine media went nutso over its prospects. This was just about the time I became a professional wine writer (although I'd been studying the wine industry and closely following developments in California for a decade prior to that). If I can sum up the general impressions conveyed by the then-famous writers, especially those in the San Francisco Bay Area, it was: At last! America's (or California's) "Burgundy" has been discovered! Finally Pinot Noir is being grown in the proper place, and vinified into wine by the proper winemakers! Now we're going to see some world-class Pinot Noir! (Good Chardonnay, too, but it's curious that Chardonnay has never "starred" in a California region or, to put it more bluntly, no region in California ever rose to fame on Chardonnay alone, the way Chablis, for instance, or Puligny-Montrachet did, in France.)
The excitement continued through, I'd say, the mid-1990s, but gradually subsided. Other Pinot Noir areas eclipsed Carneros: Russian River Valley (1983), Santa Lucia Highlands (1992), the western part of the Santa Ynez Valley now called Santa Rita Hills (2001), the Santa Maria Valley (1981), Anderson Valley (1983). It's also curious that, while several of these preceded Carneros in the date of getting appellated, it was Carneros that generated the most excitement among the critical community at that time—at least, in my memory. The reason for that may well have been that wine writing in California in the 1980s and early 1990s was dominated by Bay Area and Northern California critics (it still is, although less so), who naturally would be expected to pay more attention, in those pre-Internet days, to their own back yard than to something far away.
By the early 2000s Carneros had lost much of its luster among that community. The reasons were varied, and had as much to do with law and social custom as with wine quality. One factor that led to the diminution of Carneros's reputation was that the region, while a large one, simply lacked a critical mass of small, boutique wineries, the result of zoning regulations whose practical impact was that only large, well-heeled wine companies could afford to buy in. (The situation in, say, Santa Rita Hills and Anderson Valley was the exact opposite.) We can argue over whether a large wine company has the will to craft small, artisan wines, or not; but what is unarguable is that the critical community loves small, artisanal wineries, and is prepared to give them more of a break (if you will) than it is to large wine companies—an inequality of treatment that isn't fair; but it is what it is.
I myself, during my years as a wine critic, had no problem with Carneros. I gave lots of its Pinot Noirs high scores: Etude was one of my perennial faves, as were MacRostie, Donum, Saintsbury's single-vineyard bottlings, Kazmer & Blaise (the small project from Michael Terrien), Hartford, Signorello and the occasional Acacia. As for Buena Vista, it fared well, but wasn't exceptional: some scores of 90, 91 and 92 points, but nothing more dramatic. Why that was, is hard to say. The wines seemed unable to push their way through excellence to brilliance. It's always hard for a critic to discern why this is with a winery; the temptation to yield to simplistic explanations should be avoided. But wine writers hate to say they don't know everything.
The Buena Vista winery and brand themselves have, of course, undergone vast changes in modern times. Once California's oldest winery (1857), it went through several ownership switches; I've lost track of all the corporate parent companies, although I certainly remember Beam's overlordship, when the great winemaker (and my friend) Nick Goldschmidt oversaw its production (along with that of Clos du Bois, Atlas Peak, William Hill, Gary Farrell and others). In 2011, Jean-Charles Boisset bought the brand name and the original stone winery, in Sonoma Valley. The next year, Jackson Family Wines purchased the Ramal Road vineyard and production facility, and announced the formation of a new brand, Carneros Hills.
Which is why I'm here today. The company has high aspirations for the estate. It ought to be able to rise to levels unattained in its prior history; the terroir is just fine, and the Jackson family has sunk a small fortune into winery improvements. We'll have to wait and see how it all turns out.
* I relied upon Wine Institute data for this 1987 date. According to the TTB's website, the date of approval for Carneros was 1983.
A day in coastal California's micro-climates
It was 101 degrees in Calistoga yesterday when I left, around 4:30 p.m. By the time I reached St. Helena it was down to 94. Then 87 in Napa city. As I crossed the Benicia bridge, across the Carquinez Straights on the 101 freeway heading back to Oakland, I could see, there in the distance, a huge, glowering wall of dark gray hovering on the horizon. At first it looked like the smoke from a forest fire; but it wasn't, it was the coastal fog.
Bigger and more looming it grew as I drove south. In Richmond, I entered the maelstrom. The blue sky, the picturesque distance disappeared into the gloom; Mount Tam, to the west, vanished as completely as if it had been wiped off the face of the world. The temperature dropped until it was 65 degrees: nearly 40 degrees lower than when I'd left Calistoga, just 1-1/2 hours before. The fog hung low through Albany and north Berkeley, then evaporated as I got to Oakland, where it was again sunny, and the temperature had gone back up to the mid-70s. This was as beautiful, as classic an illustration of Cailfornia's summer coastal climate as you could possibly wish for. It's why northern Calistoga specializes in Cabernet Sauvignon (good Charbono, too), why Carneros is good for Pinot Noir, and why the near East Bay is too cold for any serious grapegrowing.
I'd been in Calistoga for a visit and tasting (of various Pinot Noirs) at Atalon, which is part of Jackson Family Wines' portfolio. It's on Tubbs Lane; nearby are Summers, Chateau Montelena, Tamber Bey and others. This is the warmest part of Napa Valley, its northwestern-most pocket, where the cooling influence from the Bay pretty much fizzles out. Bo Barrett once told me that there's something he calls "the Calistoga Gap"—no, not part of the clothing store chain, but a low place in the Mayacamas through which, he said, cooler air from the Russian River Valley funnels in, moderating the temperatures. This may be so; to get to Calistoga from the Russian River Valley (as I'd done that day), you drive east up Mark West Springs Road as it roller-coasters over the mountains, twisting and turning its way towards Highway 128/29. But it's not clear to me that the Russian River Valley air can actually find its way "over the hill", to any meaningful extent. Maybe one of my smart readers can explain this. (I had Gus beside me, in the passenger seat, and for a while he seemed like he might throw up, because his little tummy doesn't do well on twisting mountain roads. But he didn't.)
The Tubbs Lane part of Calistoga is a distinctive place. To my eye, it's a bowl of sorts: not like Napa Valley further south, in, say, Oakville or Rutherford, where you have the mountains (Mayacamas and Vacas) neatly lining the western and eastern sides, with the valley broad and expansive inbetween, like the sheet on a bed. Along Tubbs Lane there seem to be mountains everywhere except to the south; it is thus more of an amphitheater. Mount St. Helena looms immediately to the east: this picture, taken at Atalon, only hints at its majestic presence.
On the other side of the mountain, of course, is Lake County.
That 101 temperature yesterday in Calistoga shows how we're in the midst of a long, severe heat wave here in California. That's on top of the drought. The state has had some forest fires, but mainly in the Sierra Foothills and around Yosemite; the coast has largely been spared—so far. Everybody's hoping it will continue to be. The heat is expected today—as I write these words—to be even worse than yesterday, not good news for anyone, including the grapevines that are so close to being harvested in record-early time.
Although it's only August 1, I haven't heard that growers are particularly worried. In fact, the scoop is that it will be another fine harvest, coming after 2012 and 2013. Lest anyone think vintage doesn't matter in California, the evidence proves otherwise. At the Pinot Noir tasting at Atalon, which we did blind, we tasted through multiple Anderson Valley and Russian River Valley wineries, in two flights: the 2011 and 2012 vintages. There was no comparison. The 2011 flight contained some good wines but overall was disappointing. The 2012s by contrast were fat, lush, opulent. There wasn't a single loser among them.
Have a great weekend!


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Leadership During Times of Crisis
This is an extended version of an article that appeared in the March/April 2015 issue of Dimensions magazine. In times of crisis, leaders and their institutions often emerge stronger and with new insights about their values, priorities, community relationships, and human and other resources. We asked our science center and museum colleagues from around the... Read More


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Browse Hasegawa
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Due to small parts that could cause a choking hazard please keep
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tlc 7/16/14
updated tlc 10/21/14


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One hurt in Salt Lake City apartment fire
Published August 9, 2013 1:20 pm
This is an archived article that was published on sltrib.com in 2013, and information in the article may be outdated. It is provided only for personal research purposes and may not be reprinted.
Salt Lake City firefighters quickly snuffed an apartment blaze Friday afternoon, but one resident was taken to the hospital.
Deputy Fire Chief Dan Walker said the 1 p.m. blaze, which had been doused by about 15 minutes later, was reported at Homestead Studio Suites, 120 East and 2100 South.
In addition to the one fire- and smoke-damaged unit, three other units sustained some water damage.
Walker said damage in the apartment of origin was primarily limited to a bedroom by a fire sprinkler system.
One resident was transported to the hospital for treatment and observation, possibly for smoke inhalation.
The cause of the fire was under investigation.
Twitter: @remims
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In a previous post, we presented reasons churches should NOT oppose gay marriage. Now we present Matthew Lee Anderson's case for churches to oppose same-sex marriage legislation.
Few aspects of our public witness on ethical and political questions are as contentious and difficult as the questions of gay marriage and gay rights. The watershed announcement by President Obama that he too now supports full marriage equality for gays and lesbians (though he incoherently wants to leave that "right" to the states) has ignited introspection among many conservatives over whether it would be better to no longer defend traditional marriage in the public square. The danger is that articulating this particular social good has the byproduct of creating resentment and hostility from those who disagree, thereby corrupting Christianity's attractiveness by unnecessarily aligning it with a political stance.
It's worth noting, I think, that the legal developments around marriage have the appearance of being victories for conservatives but are essentially nothing more than rearguard actions. The moment a position has to be codified into law it has ceased to be the law of the land.
And yet, as someone with broadly conservative instincts I'm not yet ready to give up articulating a traditional view of marriage in public and working to support it theologically, socially, and by even by law. After all, gay marriage may not be the "foregone conclusion" that many folks think it is.
The generational voting pattern in North Carolina was considerably closer than people might have thought, and polling may be less conclusive on the side of gay marriage than it appears.
What's more, untangling the religious liberty issues that will arise upon the expansion ...
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Carbon Management Companies in North Korea
Category: Air & Climate ×
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Green Pro Invest
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Green Pro Invest is an active trader of carbon credits in the EU ETS. We are always interested in hearing from project developers about CERs or ERUs they wish to sell. Our business was set up to uncover commercial opportunities to reduce emissions of greenhouse gases, and to promote capital flows into those opportunities. Through the execution of our services, we can ...
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General Carbon Corporation has been in the activated carbon and activated charcoal business for over 55 years. We carry a large inventory of carbon and charcoal for the treatment of both air and water. We have many different types of carbon available for immediate shipment, including pelletized, granular, powdered and reactivated, made out of several different materials ...
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With 191 Parties, the United Nations Framework Convention on Climate Change (UNFCCC) has near universal membership and is the parent treaty of the 1997 Kyoto Protocol. The Kyoto Protocol has to date 175 member Parties. Under the Protocol, 36 States, consisting of highly industrialized countries and countries undergoing the process of transition to a market economy, have ...
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The Intergovernmental Panel on Climate Change (IPCC) is the leading international body for the assessment of climate change. It was established by the United Nations Environment Programme (UNEP) and the World Meteorological Organization (WMO) in 1988 to provide the world with a clear scientific view on the current state of knowledge in climate change and its potential ...
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Editorial: A new, aggressive spirit for Collier audits
Collier County history is littered with prolonged and costly conflicts between the Collier County Commission and the independently elected clerk of courts.
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