text:
Stocks kicked off December with losses after an early rally fizzled Monday.
The NYSE composite and the S&P 500 fell 0.4% and 0.5%, respectively. Both were up as much as 0.5% intraday. The Nasdaq finished with a 0.3% loss after squandering a 0.7% gain. All three indexes closed near their lows for the session, snapping a trend of strong closes.
As mentioned in Monday's column, the major indexes faced a technical test and so far they are not passing. The Nasdaq ended below resistance at its 50-day moving average after rising over the key level intraday.
But the index managed to close above the 3000 level, a big round number that has acted as support or resistance in the past.
Mirroring the Nasdaq, the S&P 500 also closed below its 50-day moving average. Monday's downside reversal also left the NYSE composite slightly below the line.
Volume cooled off sharply on both major exchanges from Friday's pace. Friday's volume (1), which was likely boosted by end-of-the-month window dressing, made for a tough comparison.
On the plus side, Monday's lower volume spared the major indexes from a distribution day (a bout of professional selling).
But upon closer examination, Friday's action on the NYSE composite marked a stalling day (2), which is a form of distribution.
Stocks were up early Monday on a round of mostly good news.
In China, the HSBC manufacturing PMI rose to 50.5 in November from 49.5 in October. That's the first above-50 reading in more than a year. Readings above 50 mean expansion, while sub-50 figures indicate contraction.
Greece announced plans to buy back bonds to lower its swelling debt.
In the U.S., construction spending jumped 1.4% in October, or nearly triple the 0.5% gain expected by economists.
But the rally ran out of steam after the Institute for Supply Management said its factory gauge fell to 49.5 in November, indicating contraction. That marked the lowest level since July 2009 and missed expectations for 51.3.
During late trading, headlines noted that House Republicans detailed a counteroffer on fiscal cliff talks. But that didn't do much for stocks.
Leading stocks were mixed. Few top-quality issues rose in heavy trade.
Qihoo 360 Technology (QIHU) bolted to its best levels since May 2011 in more than five times its average trade. The surge put it 12% past a 24.40 buy point.
The company launched its own Internet search engine in August, putting it head to head with market leader Baidu (BIDU).
SodaStream International (SODA) extended its win streak in strong volume. Beacon Roofing Supply (BECN) also gained in above-average trade.
Monday produced a breakout in candy maker Tootsie Roll Industries (TR) .
The stock cleared a big cup-with-handle. The handle of that base also could be viewed as a flat base. The company has decent ratings, but has soft growth numbers.
Click here to access the General Market Indicator Charts.
Shares of Vipshop Holdings (NYSE:VIPS) leaped as much as 11% Friday, as the online-discount retailer and other U.S.-traded China-based stocks got a boost from a rally in China's stock market. Vipshop appears to be immune from China's "challenging economy" and expects healthy revenue growth in Q3 ...
The autonomous vehicle space is starting to turn into a traffic jam as General Motors gets help from Mobileye to speed up development of self-driving Chevrolet Volt plug-in hybrid cars. GM (NYSE:GM) said Thursday that it's working on a "heightened partnership" with the provider of advanced ...
Chinese Internet search engine Baidu (NASDAQ:BIDU) was downgraded early Wednesday, while drugmakers Valeant Pharmaceuticals International (NYSE:VRX) and Shire (NASDAQ:SHPG) also saw analyst action. Baidu was downgraded to hold at Summit Research and given a 170 price target, which is below the ...
Baidu (NASDAQ:BIDU) got its second price target cut in two months on Wednesday from Summit Research/W.R. Hambrecht + Co., highlighting earlier doubts that China's search leader can dominate the increasingly competitive online-to-offline (O2O) sales arena even while spending millions to beef up its ...
China-based stocks in the U.S. have largely resisted a Monday sell-off across American and European markets that had fed into a steep drop in China's markets. On Tuesday, the Shanghai Composite folded 2%, wiping out its 0.3% gain on Monday. Hong Kong's Hang Seng index caved 3%. A number of market ...
Modest winning streaks for the S&P 500 and Nasdaq came to an end Tuesday, but damage was limited. The Nasdaq fell 0.7% in higher volume, resulting in a distribution day, but it managed to close in the upper half of its intraday range. Biotechs were weak again, but overall breadth wasn't too bad ...
With just one day after the S&P 500's bullish follow-through signal, Monday's action could be summed up as "pretty good so far" for the new uptrend. Energy and material stocks helped the S&P 500 to a 1.8% gain. The benchmark index has now climbed for five straight sessions, marking its longest win ...
Stocks staged a positive reversal Friday, turning big losses at the open into solid gains by the close. The Nasdaq scored a 1.7% advance after being down 1.6%. The S&P rose 1.4%. The IBD 50 lagged with a 1% pop. Volume rose on both major exchanges. The gains in rising volume pointed to ...
Stocks wandered to a nearly flat finish Thursday, unable to follow up much on the previous session's big gains. The Nasdaq inched up 0.1%, while the S&P added 0.2%. The IBD 50 rose 0.7%. Volume fell across the board. The day's action did nothing to remove the doubts surrounding the market. ...
Stocks blasted upward Wednesday, and even volume grew. Yet with the market still in correction mode, it's still relatively slim pickings for hunters of good stock breakouts. On an ultra-skinny list of stocks that surpassed a proper buy point, two are NYSE-listed: Universal Insurance (NYSE:UVE) ...
Investor's Business Daily provides exclusive stock lists, investing data, stock market research, education and the latest financial and business news to help investors make more money in the stock market. All of IBD's products and features are based on the CAN SLIM® Investing System developed by IBD's Founder William J. O'Neil, who identified the seven common characteristics that winning stocks display before making huge price gains. Each letter of CAN SLIM represents one of those traits.


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Baby Car, Travel and Buggy Accessories
Buggy Clip
Buggy Clip
Reviews (46)
Reviews (46)
Want to add your own review ?
Deirdre Mcdonnell
on 24 September 2015
easy to clip on and off as well as robust.
Sarah f
on 14 July 2015
This is my second at the first only lasted about 6 months. The clips themselves are so useful but hoping this one has a better life span!
on 14 May 2015
A good sturdy product. Really pleased with it.
Claire Drayton
on 03 April 2015
Strong sturdy clip, good product for price. As always, jo jo deliver promptly.
on 30 March 2015
I bought this as a replacement and it's so much sturdier than my last one. Really chunky and strong
on 19 December 2014
Great strong clip, holds heavy weights and keeps bags secure.
S Hotard
on 25 June 2014
The clip is very sturdy, strong and stays in place perfectly on my buggy handlebar. Brilliant to pop my shopping bags on to. A must have buggy item for me!
Mel Collis
on 04 June 2014
A brilliant item that is so useful and handy on the pram
on 02 June 2014
Great product, sturdy
on 21 May 2014
This clip is really great. I do not have to worry about my handbag any more. There are so many things you have to worry about with a baby that you might become an easy target for buglers if you do not take precautions. Bags cannot be stolen from this clip, especially when on holidays in foreign countries I enjoy the peace of mind it gives me.
Emma baker
on 18 March 2014
Very useful and easy to attach and detach meaning I can use it easily between my two prams.
Katie Wood
on 20 November 2013
Very sturdy. Fits perfectly around Mamas and Papas Sola pushchair.
Claire Way
on 07 October 2013
great idea, but does'nt work well on a phil and teds sport as the handle is too thick ! but great for other pushchairs
on 06 September 2013
a very good and useful product!
on 06 June 2013
The Buggy Clip is a fabulous gadget, well priced and does exactly what it is supposed to be doing: making mum's life easier! The item was not in stock at the time of purchase but the JoJo Maman Bebe team kept me up to date with the next possible delivery of the item. They did manage to get it sooner which I was obviously very pleased about. Fantastic customer service!
on 09 May 2013
Be careful when buying these as, although they look good quality, it didn't fit on to the handle of my Stokke buggy which isn't particularly large in diameter.
on 06 May 2013
A must have item.
on 30 April 2013
Very handy, good value and easy to use, my 4 year old also uses it as a handle to hold onto the pushchair.
on 19 April 2013
Great idea, simple to use and plenty big enough. (Did wonder if I should get the bigger clip.)
Lesley Thompson
on 10 April 2013
This clip is exactly what I have been looking for. It fits my Phil&Teds well and means I can carry on the side of the buggy my shopping, library books, snacks, nappies and all the other things that I usually try to balance on the top. No more steering the buggy badly with one arm whilst trying to lug my bags with the other. Quite a handy contraption, I'm mighty pleased.
on 08 April 2013
Big and chunky. Feels good quality and strong
on 05 February 2013
Arrived quickly. Works well and fits onto my Phil and Ted Vibe pushchair. It carries the kids school stuff, lunch boxes and school bag etc, couldn't be without it now!
on 22 January 2013
Excellent, sturdy clip - holds lots of heavy shopping! Excellent value for money, I wouldn't be without mine.
on 17 January 2013
Useful clip which fits well to the pram. Holds a lot more than I expected
on 04 January 2013
Very useful. Only had it for a week and its already been very well used. Seems robust and like it'll last.
Yorkshire Granny
on 26 December 2012
My daughter-in-law was delighted with this gift to solve the problem of carrying a handbag while pushing a buggy. Neat and effective . Thank you.
Rachael Franklin
on 18 December 2012
Excellent product, easy to use and a godsend for any mum with a pram and shopping! I'd actually rather take my pram everywhere now I have this, rather than carry all my shopping around!
on 17 November 2012
really good. so much easier than the plastic clips that ping off at the slightest touch. very sturdy would definately recommend
heidi marriott-trevains
on 16 November 2012
This clip holds a good deal on weight, particularly as the clip itself is surprisingly light.
on 19 October 2012
This is an excellent little addition to my pram which apart from small basket for shopping had no other hooks for bags. Works v. well!
Lauren Engledow
on 17 October 2012
Fantastic! Would definitely recommend. No more struggling with the shopping and the pram!
Kirsty finkill
on 26 September 2012
These clips are brilliant, i have both sizes, i tend to use the smaller for coats so they don't get screwed up under the pushchair. I can fit 2 lunch boxes and 2 book bags easily on the bigger 'mummy clip' and my girls use it as a handle too. Smaller clip can be more fiddly to attach depending on how wide your handle is, I put it on further down the bar and then slide up to where i want it. Order process and delivery really easy and quick.
Samantha Budge
on 19 September 2012
Excellent product, excellent service and free delivery. Very impressed all round
on 18 September 2012
This buggy clip is excellent! Perfect for carrying shopping or library book bags. Great buy!
C Farley
on 16 September 2012
Great to start with but it broke inside. It was quickly replaced but the same thing happened again.
I didnt load it up or over use it. Metal poked out so I binned it and got another type.
on 12 July 2012
Very sturdy, takes alot of weight, although the bugy can tip if bag too heavy so take care. Foam grip means it doesnt slide around either.
on 03 July 2012
So handy for carrying the shopping not sure how i coped without it now!
on 26 June 2012
Excellent purchase, all buggies should come with these clips as standard !
on 15 June 2012
My buggy did not come with any hooks or clips for bags so this is ideal. Feels sturdy and strong. The foam type material means that it stays put and does not slide up and down. Great purchase!
on 13 June 2012
An essential item especially if your pram/pushchair has a small or no shopping basket. Have bought these for friends/first time Mums and always a winner!
on 08 June 2012
Very good, sturdy and allows me to carry alot more without having to struggle
S Bourne
on 03 June 2012
These are just what I have beel looking for! After breaking numerous plastic buggy clips through carrying twins change bag I needed something stronger and harder wearing.
on 08 May 2012
Great product. It's smaller than the mommy clip, just what I wanted. Perfect for putting on the handle of my phil & teds, and strong enough to hold my changing bag.
on 07 May 2012
Really pleased with this purchase - it makes shopping a lot easier! Great size & very robust. Would recommend this product.
on 29 March 2011
Fantastic, the answer to my phil and teds lack of storage problem. I bought this and the mommy clip. They are identical except the mommy clip is significantly larger. It is handy having two one on either side.
on 13 December 2010
Really useful and easy to use. Robust and good design. Bags can't fall off. Room for several bags but be careful they aren't too heavy or you will destabilise the pram!
Product Info
Buggy Clip
Keeps bags really secure on your buggy.
Innovative snap on smaller hook in robust aluminium that will carry any load and fit any buggy or pram.
Built to last - it won't fall off or break
Non-slip padding prevents it sliding
Be careful not to overload your buggy as this may cause instability
Unfortunately we are unable to deliver this item to UNITED KINGDOM.
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posters, still life paintings posters, still life art for men posters, masculine still life posters, fishing tackle posters, masculine posters, paddles still life posters, snowshoes still life posters, canoe paddles posters, duck decoys posters, bird house still life art posters
"Where The Heart Is" poster by Hanne Lore Koehler. Ships within 3 - 4 business days and arrives rolled in a tube. Multiple sizes available.
All prints ship in durable cardboard tubes.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality posters and prints. All of our posters are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
Escape from daily hectic life in the summer sweltering cities of Southern Ontario often means a mass exodus every Friday on highway 401 north on highways 400, 11 and 69 to cottage country. Bracebridge, Haliburton, Muskoka, Parry Sound, Gravenhurst, Huntsville - these names conjure up summer swimming and boating fun, lazy days of floating on a raft in a sun-drenched lake, happy sounds of children laughing, belly-flop splashes, sizzling burgers on the barbeque, evening stories and sing-alongs around a bonfire. This is heaven - this is where the heart is. This Masculine Still life Painting by contemporary still life artist Hanne Lore Koehler features a cottage window scene with life jackets, snowshoes, fishing tackle, duck decoys, fishing...
CONTACT ME for painting commissions and inquiries about original paintings. Born in Aachen, Germany, I grew up in Ontario, Canada, where I still live with my husband (the love of my life) and family, from which comes the inspiration for much of my work. My vibrant watercolors, acrylic and oil paintings cannot be labelled in only one category. My paintings reflect my life: enriched with excitement as well as quiet times. My fascination with capturing a flash of movement in a motionless art form is evident in my sports paintings and energetic portraits. Moments of tenderness are reflected in my still life art, gardens and landscapes. Humor and silliness reflect in my fantasy illustrations. Many aspects of my life are mirrored in...
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that 337,835 artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
Customer Service: 877-807-5901
(Call Any Time - 24 Hours Per Day)
All posters ship from our production facility within 24 hours of your order.


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82 reviews | 4.6 out of 5
Heath Ledger was Great in this Movie To bad we Lost a Great
The Dark Knight is a great movie! Though I would not recommend it for children under 13 due to the dark nature of the film, the movie is still very enjoyable, and very well done! A must have for any DVD / Blu Ray collection!
Great Movie! Good price too!
it is an awsome movie and it came 2 days befor the holidays in perfect condition
Well written, very good acting!
Got this as a gift to young boy who loves batman. Great price!
I saw the movie in theaters, but when it came to dvd I was rather dissapointed-no interviews or featurettes on the 2-disc special edition, I only keep it because I personalized the case, the art work to me was ridiculously cheesy, but the three trailers almost made it worth the price.
This is an excellent movie. I saw it at the theater twice. But I was very disappointed to find out there wasn't ANY bonus material on the the single disc version. If you are looking for bonus material get the 2disc version.
went and saw this movie 7 times before buying this movie, very entertaining. I recommend this
Great movie and great buy. Shipping needs a little work, somehow they had the right address on walmart.com and the UPS site, but the courier had a different address so I got the movie a few days later than expected.
Heath Ledger was awesome as the Joker.. There will never be an actor that can match his joker
Not only was I able to pre-order The Dark Knight before release date, but I was able to have it shipped right to my front door. The movie itself, is the best of 2008!
This movie was full of action. I wanted to bite my fingernails throughout the whole show.
Excellent Movie!
Have plenty of Popcorn and Chocolate:)
Phenominal movie, with Heath Ledger just killing it. We'll never have another actor who can do the joker like him. Great movie, highly recommended.
Heath Ledger is BRILLIANT in the role of the Joker!!! He makes me forget anyone ever played that part before!! He was a genius already, but has leapt to SUPER genius with his portrayal of the Joker!! He better get an Oscar and every other award known to mankind for what has become his final screen performance!!
This is a great movie and we got a decent deal. I would recommend this movie to anyone.
This is the best film of 2008 in my opinion. Site to store shipping was a breeze and I will use that option when ever it is available from now on. Great Price & I love it!
My 10 year old nephew received the movie for Christmas and it was a movie the whole family enjoyed.
Was quite happy with condition of product and condition for package. Had no problems at all when I used the DVD. Was quite happy with the whole process of ordering on line and coming in to get the product. Saved time, and made shopping during the holidays quite enjoyable and quick. Have told all my friends about the experience and how quick and easy the whole process was and how I had no problems with any of it and that I will do again as was quite happy with how easy it all was. You are making it so easy to do shopping and keep up the good work!


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Facebook has been accused of "encouraging intellectual property theft" by YouTube star Hank Green in a blog post recently.
Pitching for deeper bilateral ties, Germany said India has "enormous" investment potential for which "right" conditions have to be created and stressed on legal protection for IPR.
The US industry will wait to hear the Narendra Modi government's stand on protection of Intellectual Property Rights when PM meets business leaders.
The US has urged successive Indian governments to create a regime that will protect the intellectual property rights of its enterprises that invest in India.
IIT Kharagpur has signed an MoU with the Law School of George Washington University (GWU) for students and faculty exchange.
India registers 34.4 patents in regards to per million people as compared to other developed countries, the government today said.
The Commerce and Industry Ministry is expected to soon approach the Cabinet for its nod for the proposed National Intellectual Property Rights policy.
The commitment to contentious policies could require US tech companies to turn user data and intellectual property over to the government.


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Welcome, Anti-Social Socialites!
Internationally acclaimed musical artist "drumfish" at the 8x10 this Saturday
- Needs a location
- Coming soon
drumfish will be sharing the night with Finnegan's Woo at the 8x10 in Baltimore this Saturday. drumfish is an internationally acclaimed Indie Alt Rock band who has... Learn more
- 3 more until it's announced
A former member added this Meetup
Recent Meetups
Oct 25, 2014 · 7:00 PMstuArt's 3rd ANNUAL HALLOWEEN COSTUME BONFIRE-POT LUCK & GREAT TRAIN ROBBERY DUODRUM CIRCLE BY REVE ELLIE SO BRING DRUMS, RATTLES, METAL BUCKETS, YOU GET IT. ALL NOISE MAKERS LIVE MUSIC BY A DUO FROM 'GREAT TRAIN ROBBERY' BOOZE, FOOD... Learn more
Sep 24, 2014 · 6:30 PMA little gastronomic research of the crabcake-kind...So I heard/read/something that this place was rated as having the SECOND-BEST crabcakes in Baltimore - more importantly, they were rated as being better than Koco's.... Learn more
Jul 18, 2014 · 9:00 PMRandi's Spiral Dance Party @ Michael's in TimoniumRandi says "Spin your top with "Spiral" on Friday Night July 18th! Get out and get over to Michael's!" If you have never heard this band before, you are certainly in for... Learn more
Jul 16, 2014 · 5:00 PM"FULL MOON-LASSO YOUR ASS FOR A FULL MOON BLAST!ASS'ES COME OUT AND PLAY-AFTER ALL IT IS "HUMP DAY"! DON'T WASTE YOUR LIFE NOT BEING ABOUT-SO COME OUT AND HAVE A "GREAT DAY"! :-)
Jul 4, 2014 · 7:00 PMSONS OF PIRATESCOME OUT AND PLAY WITH A "GREAT" GROUP. OUR GROUP AND THE BAND. AFTER ALL IT IS THE FOURTH OF JULY. THE SUMMER WILL BE OVER BEFORE WE KNOW IT-SO DON'T WASTE IT! SIGN-UP... Learn more
- See all past Meetups


text: This was a great value for the money- great location in a calm part of Miraflores almost to the Magdalena del Mar neighborhood. Wifi was fast, shower was warm. Rooms were clean, comfortable, new (without that musty smell some worn hotels get in Lima), and had comfy bedding and fun, quirky Andean decor. Staff was super helpful and fantastic breakfast... More


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Page 1
Glucose fluctuations and activation of oxidative stress
in patients with type 1 diabetes
I. M. E. Wentholt & W. Kulik & R. P. J. Michels &
J. B. L Hoekstra & J. H. DeVries
Received: 14 April 2007 /Accepted: 30 August 2007 / Published online: 10 November 2007
# Springer-Verlag 2007
Aims/hypothesis Glucose fluctuations may help predict
diabetic complications. We evaluated the relation between
glucosevariabilityand oxidative stressin patientswithtype 1
Methods Continuous glucose monitors were inserted sub-
cutaneously in 25 patients. During the measurement,
patients collected two 24 h urine samples, while 24 healthy
controls collected one 24 h urine sample for determination
of 15(S)-8-iso-prostaglandin F2aPGF2a
tandem mass spectrometry. Mean of the daily differences
(MODD), mean amplitude of glycaemic excursions (MAGE)
and continuous overlapping net glycaemic action calculated
with n hour time-intervals (CONGA-n) were calculated as
markers for glucose variability and correlation with
15 S ð Þ‐8‐iso‐PGF2αexcretion was calculated.
Results Median [interquartile range (IQR)] urinary 15 S ð Þ‐
8‐iso‐PGF2αwas higher in patients than healthy controls:
ðÞ using HPLC
161 (140–217) pg/mg creatinine vs 118 (101–146) pg/mg
creatinine (p=0.001). Median (IQR) MODD was 3.7 (3.2–
5.0) mmol/l, MAGE 7.6 (6.4–9.0) mmol/l and CONGA-1
2.3 (2.1–2.8) mmol/l. Univariate regression did not reveal
an association for MODD (r2=0.01), MAGE (0.08) or
CONGA-1 (0.07) with 15 S ð Þ‐8‐iso‐PGF2α excretion, nor
was an association revealed when corrected for HbA1c, age,
sexandsmoking.Spearmancorrelationcoefficients(r) between
15 S ð Þ‐8‐iso‐PGF2α excretion and MODD, MAGE and
Conclusions/interpretation We report that there is no rela-
tionship between glucose variability and urinary 15 S ð Þ‐
8‐iso‐PGF2α. We also confirm that patients with type 1
diabetes have higher levels of urinary 15 S ð Þ‐8‐iso‐PGF2α
than healthy controls, suggesting that in addition to glucose
variability, other factors favouring oxidative stress may
exist. We did not see a relation between high glucose var-
iability and elevated levels of oxidative stress in patients
with type 1 diabetes.
Keywords Complications.Continuousglucose
monitoring.Glucose variability.Oxidativestress.
Type1diabetes.Urinary15 S ð Þ‐8‐iso‐PGF2α
continuous overlapping net glycaemic action
calculated with n hour time-intervals
HPLC tandem mass spectrometry
interquartile range
mean amplitude of glycaemic excursions
mean of the daily differences
prostaglandin F2a
Diabetologia (2008) 51:183–190
DOI 10.1007/s00125-007-0842-6
I. M. E. Wentholt (*):R. P. J. Michels:J. B. L. Hoekstra:
J. H. DeVries
Department of Internal Medicine, Academic Medical Center,
Meibergdreef 9,
1105 AZ Amsterdam, the Netherlands
e-mail: firstname.lastname@example.com
W. Kulik
Laboratory for Genetic Metabolic Diseases,
Academic Medical Center,
Amsterdam, the Netherlands
I. M. E. Wentholt
P.O. Box 22660, 1100 AD Amsterdam, the Netherlands
Page 2
Hyperglycaemia is the main risk factor for developing
microvascular complications and accelerates atherosclerosis
in diabetes [1, 2]. The present paradigm postulates that
mitochondrial glucose overload results in increased electron
transfer to oxygen and formation of free oxygen radicals.
This in turn activates four pathways along which hyper-
glycaemia can induce diabetic complications [3]. There is
also some evidence that hypoglycaemia may contribute to
platelet activation and thereby to macrovascular complica-
tions. The mechanisms through which both hyper- and
hypoglycaemia contribute to diabetic complications is
schematically depicted in Fig. 1 [4, 5].
Recent studies with continuous glucose sensors found a
large range of glucose values in children with type 1
diabetes, even in those with excellent HbA1cvalues, which
raises the possibility that in addition to HbA1c, glucose
variability may have predictive value for the development
of diabetic complications [6–8]. Although this has been
negated for microvascular complications [9], it is an
attractive hypothesis to explain the increased macrovascular
burden of type 1 diabetes [10]. A recent study investigated
the effect of long-term glycaemic exposure, as indicated by
HbA1c, and acute glucose fluctuations quantified with a
continuous glucose monitor on the activation of oxidative
stress in 21 type 2 diabetic patients on either oral glucose-
lowering medication or a weight-controlling diet and
compared activation of oxidative stress with age and sex-
matched healthy control persons. This study revealed
significantly more oxidative stress in patients with type 2
diabetes than in healthy control persons and demonstrated
that acute glucose fluctuations in particular induce oxida-
tive stress. These fluctuations were suggested to be valuable
predictors for the risk of diabetic complications [11].
Activation of oxidative stress was estimated from the mea-
surement of 24 h urinary excretion of 8-iso-prostaglandin
free oxygen radical-mediated oxidation of arachidonic acid
and have been demonstrated to increase with oxidant injury,
they are considered good indicators of oxidative stress [12,
13]. The daily glucose fluctuations were quantified with the
mean amplitude of glucose excursions (MAGE), calculated
from the continuous sensor readings [11].
To date, the role of acute glucose fluctuations in
activation of oxidative stress has not been investigated in
patients with type 1 diabetes. Insulin therapy, higher insulin
sensitivity and affected counter-regulation to hypoglycae-
mia will contribute to more pronounced glucose fluctua-
tions in patients with type 1 diabetes than in those with
type 2 diabetes. The aim of our study was to evaluate the
monitor, in the activation of oxidative stress in patients with
type 1 diabetes and to determine the amount of oxidative
stress in these patients as compared with healthy control
Þ. Because isoprostanes are stable products from
The study was approved by the local ethics committee and
participants gave written informed consent. Twenty-five
patients with type 1 diabetes and 24 age- and sex-matched
healthy controls were enrolled in the study. The main
clinical characteristics are listed in Table 1. Hypertension
was defined as receiving antihypertensive treatment. Dia-
betic retinopathy, nephropathy and neuropathy were de-
fined as having had laser coagulation, microalbuminuria
requiring therapy with ACE inhibition and altered or
diminished sensibility in hands and/or feet, respectively.
Macrovascular complications were defined as coronary
artery diseases, e.g. angina pectoris or acute myocardial
infarction, and/or cerebrovascular events in the medical
history. Seven patients were using an insulin pump, all with
a rapid-acting analogue as pump insulin, and 18 patients
were being treated with multiple daily injections. Of the
latter, 13 were on a combination of long and rapid-acting
insulin analogues (glargine, detemir and lispro, aspart), one
on human insulin only, three on a combination of rapid-
acting human insulin and basal insulin analogues and one
on rapid-acting insulin analogues and basal human insulin.
Exclusion criteria were a BMI >30 kg/m2, a GFR of less
than 60 ml min−11.73 m−2according to the Cockcroft–
Gault formula [14], heparin, oral anticoagulants or cortico-
steroid use, skin conditions prohibiting sensor needle
insertion and any febrile illnesses during the 3 month
period prior to the experiment.
Platelet aggregation
Free oxygen radicals
Flux polyol route
Hexosamine activity
Activation PKC
Production AGE
DNA damage
PARP activation
GAPDH inhibition
Fig. 1 Overview of the mechanism of hyper- and hypoglycaemia-
induced complications. GADPH, glyceraldehyde-3 phosphate dehydro-
genase; PARP, poly (ADP ribose) polymerase; PKC, protein kinase C
184 Diabetologia (2008) 51:183–190
Page 3
Study protocol
The experiment consisted of two short visits to the clinical
trial room. During the first visit the continuous glucose
sensor (CGMSgold; MedtronicMiniMed, Sylmar, CA,
USA) was inserted subcutaneously in the abdominal
periumbilical area of the patients and, if present, the insulin
pump on the other side. Patients injecting insulin were
asked not to inject on the same side as the sensor insertion
side in the week prior to and during the period of
measurement. Home blood glucose meters (Accu-Check
Compact Plus; Roche Diagnostics, Quebec, Canada) were
provided to perform the sensor calibration procedure four
times daily. Information about diabetes duration, complica-
tions and current mode and dose of insulin therapy was
recorded in the case record form. A venous blood sample
was collected for HbA1cdetermination. Patients were asked
to collect urine during two consecutive 24 h periods. They
were instructed to preserve the urine-containing jars in the
refrigerator when at home and in special cooling bags when
outdoors, in order to avoid artificial formation of isopros-
tanes. For optimal prevention of artificial isoprostane
formation, patients noted the total urine volume after
24 h, mixed the urine thoroughly, and divided 14 ml urine
equally into two tubes, which were placed in a freezer until
the second visit. The same procedure was done with the
second 24 h urine collection. In addition, patients received
a study diary to record their meals and symptomatic hypo-
or hyperglycaemic events. Three days later, patients
returned to hospital to have the sensor removed and data
downloaded, and to hand in the frozen urine tubes together
with the study diary. Healthy controls were asked to do one
24 h urine collection, as described above for the patients
with type 1 diabetes. For both the patients and healthy
controls, age, concomitant medication, smoking, height and
weight and the resulting BMI were recorded. As the
association with lower oxidative stress levels is still
controversial [15–18], participants were asked not to take
vitamin E tablets during the experiment. Finally, the urine-
containing tubes were stored at −80°C until analyses for
15 S ð Þ‐8‐iso‐PGF2αand creatinine in one run.
Laboratory measurements
HbA1c was measured using an HPLC assay (Variant II;
Bio-Rad Laboratories, Montreal, QC, Canada). Activation
of oxidative stress was estimated by determining the
urinary isoprostane excretion (15 S ð Þ‐8‐iso‐PGF2α), using
HPLC tandem mass spectrometry (HPLC-MS/MS). Urine
samples were collected and stored without additives as 7 ml
lished by colorimetric Jaffé assay. Two millilitres of sample
was mixed with2H4-labelled 15 S ð Þ‐8‐iso‐PGF2αas internal
standard and applied to an 8‐iso‐PGF2α immunoaffinity
column (CaymanChemical Company, Ann Arbor, MI, USA).
After washing, the extract was eluted, evaporated to dryness
(60°C, N2) and reconstituted in 200 μl 0.05 mol/l formic
acid–ethanol (75:25, vol./vol.); 50 μl was injected on the
HPLC-MS/MS. Chromatographic separation was achieved
on a modular HPLC system (Surveyor; Thermo Finnigan,
Table 1 Clinical characteristics
Unless otherwise stated, data
are means±SD oramedian
bPatients vs controls, Mann–
Whitney U test
cPatients vs controls, Pearson's
dPatients vs controls, indepen-
dent samples t test
CharacteristicsPatients Controlsp value
Men/women (n)
Age (years)a
Cigarette smoking [n (%)]
BMI (kg/m2)
Diabetes duration (years)
Diabetes treatment [n (%)]
Insulin pump
Multiple daily injections
Total daily insulin dose (IU/24 h)
Complications [n (%)]
Systolic blood pressure (mmHg)
Diastolic blood pressure (mmHg)
Hypertension [n (%)]
HDL-cholesterol (mmol/l)
Total cholesterol (mmol/l)
Triacylglycerol (mmol/l)
39.0 (28.5–49.5)
8 (32)
35.0 (29.0–44.0)
4 (16.7)
7 (28)
18 (72)
48.7 (16.3)
6 (24)
4 (16)
3 (12)
2 (8)
4 (16)
Diabetologia (2008) 51:183–190185
Page 4
San Jose, CA, USA) consisting of a cooled autosampler (T=
12°C), a low-flow quaternary MS pump and analytical
HPLC column: 2.1×150 mm, 5 μm Alltech C8 (Alltech
Lexington, KT, USA). Samples were eluted with a flow rate
of 200 μl/min and a programmed gradient between A
(HCOOH–H2O; 0.01%, vol./vol.) and B (CH3CN). MS/MS
analyses were performed on a TSQ Quantum AM (Thermo
Finnigan) operated in the positive ion electrospray ionisation
mode. The surface-induced dissociation was set at 15 V;
spray voltage was 3,000 V and the capillary temperature
was 300°C. In the MS/MS experiments argon was used as
collision gas at a pressure of 0.2 Pa; collision energy was
20 eV for the optimised transitions: m/z 353.24→m/z 193
and m/z 357.24→m/z 197.10. The inter-assay (n=5) and
intra-assay (average of 5 days, n=3) variability allowed
for determination at physiological concentrations with
a CV <7%.
Assessment of glycaemic variability
Inter-day glycaemic variability The day-to-day variation of
the glucose pattern was calculated with the mean of the
daily differences (MODD), which is defined as the mean of
the absolute differences between glucose values on day 2
and the corresponding values on day 1, at the same time
[19, 20].
Intra-day glycaemic variability Because there is no con-
sensus on how to optimally assess glucose variability and to
prevent the results from being affected by the method
chosen, we performed multiple calculations to estimate the
glucose variability. The easiest measure is the CV defined
as the SD divided by the mean of the glucose values.
Another marker of glucose variability is the MAGE,
designed by Service et al. [21] in 1970. The MAGE over
24 h is the mean of the absolute differences between peak
and nadir values over 24 h, with peaks (nadirs) defined as
glucose values preceded and followed by an increase
(decrease) and decrease (increase), respectively, in excess
of at least 1 SD of the mean glucose. If a decrease of more
than 1 SD was the first excursion, only peak-to-nadir
excursions (>1 SD) were included in the calculation of the
MAGE and vice versa. We calculated the MAGE over both
24 h urine collection periods separately and over the two
periods taken together.
Rapid glucose variability We also calculated the recently
proposed continuous overlapping net glycaemic action
calculated with n hour time-intervals (CONGA-n), to gain
insight into the rapid glucose variability. With this method,
the difference between each glucose reading and the
glucose reading n hours previously (as determined by the
investigator) is calculated. The CONGA-n is the standard
deviation of these differences. We used CONGA-1,
indicating intra-day variability based on 1 h time differ-
ences, to allow for comparison of our results with those
reported in other articles [19, 22]. In normal non-diabetic
participants, CONGA values vary between 0.4 and 1.2:
values above 1.5 indicate glycaemic lability [19]. Further-
more, we calculated the within-hour glucose SD and range,
as markers of rapid glucose variability.
Statistical analysis
Mean urinary excretion of 15 S ð Þ‐8‐iso‐PGF2α, inter- and
intra-day and rapid glucose variability were assessed using
standard statistics. The intra-individual day-to-day variation
of the above-mentioned variables was calculated using a
paired samples t test or Wilcoxon's signed rank test, de-
pending on the distribution of the data. Oxidative stress was
Table 2 Glucose variability and glycaemic excursions
CGM, urine collection 1 CGM, urine collection 2CGM, collections 1+2p value
Mean glucose (mmol/l)
SD (mmol/l)
Inter-day variation
MODD (mmol/l)
Intra-day variation
MAGE (mmol/l)
Rapid glucose variability
Within-hour range (mmol/l)
Within-hour SD (mmol/l)
9.0 (±2.2)
3.29 (±1.07)
9.3 (±1.8)
3.45 (±1.28)
9.1 (±1.8)
3.61 (±1.05)
0.37 (0.29–0.44)
6.9 (6.2–8.7)
0.37 (0.30–0.44)
7.8 (5.2–9.7)
0.42 (0.31–0.47)
7.6 (6.4–9.0)
2.5 (2.0–2.7)
2.0 (1.7–2.2)
0.69 (0.58–0.74)
2.5 (1.9–3.1)
2.1 (1.6–2.8)
0.70 (0.55–0.95)
2.3 (2.1–2.8)
2.0 (1.7–2.5)
0.66 (0.58–0.84)
Variability and excursions were indicated by several markers, derived from continuous glucose monitoring data during the first, second and total
48 h of urine collections, respectively
Data are means (±SD) or medians (25th–75th percentile)
CGM, continuous glucose monitoring
186Diabetologia (2008) 51:183–190
Page 5
compared between the patients with type 1 diabetes and the
age and sex-matched healthy controls, using an indepen-
dent samples t test or Mann–Whitney U test, again
depending on the distribution of the data. Correlation was
calculated and univariate regression analysis was performed
to evaluate the relation between the excretion rate of urinary
15 S ð Þ‐8‐iso‐PGF2αand the markers of glycaemic variability,
results being corrected in multivariate regression analysis
for long-term glycaemic control as indicated by the HbA1c
level [15, 23], sex [24], age [25] and smoking [17, 18, 26],
all variables that have been reported to be involved in the
activation of oxidative stress. For lipid values and blood
pressure, we also evaluated the association with urinary
excretion of 15 S ð Þ‐8‐iso‐PGF2α in a univariate model. In
the event of a significant relation in the univariate analysis,
variables were included in a multivariate model to evaluate
the determinants for oxidative stress. p values of <0.05
were considered significant.
One patient discontinued the sensor measurement after
approximately 24 h, because of a putative allergic reaction
against the inserted sensor needle. Patients wore the
continuous glucose monitor for a period ranging from 50
to 72 h. In total, data of continuous glucose measurements
during 49 24-h periods, together with the concomitant
urinary 15 S ð Þ‐8‐iso‐PGF2αexcretion levels, were obtained
in 25 patients with type 1 diabetes. The 15 S ð Þ‐8‐iso‐PGF2α
excretion levels during a single 24-h period were obtained
in 24 age- and sex-matched healthy controls. There were no
major differences in age, BMI and smoking between the
two groups (see Table 1).
Data on inter-day, intra-day and rapid glycaemic vari-
ability are summarised in Table 2. The median (interquartile
range [IQR]) urinary excretion of 15 S ð Þ‐8‐iso‐PGF2α, cal-
culated over two urine collection periods, in the patient
group was 161 (140–217) pg/mg creatinine (Fig. 2). There
was no significant difference in 8‐iso‐PGF2αexcretion be-
tween the first and the second urine collection (172 [147–
231] pg/mg creatinine vs 157 [139–218] pg/mg creatinine,
p=0.162, Wilcoxon signed rank test), while the between-
patient variability significantly exceeded the within-patient
variability(p=0.009, Kruskal–Wallis test). The median (IQR)
urinary excretion of 15 S ð Þ‐8‐iso‐PGF2α was significantly
lower in healthy control persons than in diabetes patients:
118 (101–146) pg/mg creatinine (p=0.001, Mann–Whitney
U test). Data on MAGE and oxidative stress, assessed in the
patients with type 1 diabetes, are plotted in Fig. 3, clearly
illustrating the absence of any relationship between these
two variables. Univariate regression analysis revealed that
none of the markers of glucose variability were associated
with the urinary excretion rate of 15 S ð Þ‐8‐iso‐PGF2α (an-
Patients with type 1 diabetes
123456789 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Excretion of 8-iso-PGF2α (pg/mg creatinine)
Fig. 2 Urinary excretion of
15 S ð Þ‐8‐iso‐PGF2αfor all 25
patients with type 1 diabetes
during the first (black bars)
and second (grey bars) 24 h
urine collection
MAGE (mmol/l)
8-iso-PGF2α(pg/mg creatinine)
Fig. 3 Scatter plot showing MAGE vs oxidative stress. A regression
line could not be drawn
Diabetologia (2008) 51:183–190187


text:
Kukla's Korner Hockey
Category: Los-Angeles-Kings
Problems Still Exist With The Los Angeles Kings
by Paul on 07/05/15 at 08:51 AM ET
Comments (0)
from Lisa Dillman of the LA Times,
Everyone knows Kings Coach Darryl Sutter loves to play youngsters. That is sarcasm — but Sutter might have no choice.
General Manager Dean Lombardi has noted that the Kings don't have a lot of cap space to make a big move, which is why they weren't able to keep "rental defenseman" Andrej Sekera, who went to the Edmonton Oilers for a six-year, $33-million deal, or veteran Justin Williams. The forward went to the Eastern Conference, joining the Washington Capitals for a two-year deal worth $6.5 million.
There are two problematic issues for the Kings, the first concerning center Mike Richards, whose contract has been terminated by the club. But the expectation is that the NHL Players' Assn. will appeal that move. Until the matter is resolved, the Kings won't know their options for sure. If worst came to worst, they could always put him in the minors indefinitely.
Equally problematic is the situation revolving around defenseman Slava Voynov. After pleading no contest to a misdemeanor in the wake of a domestic violence charge, Voynov has been sentenced to 90 days in jail, meaning there is a chance he could still be unavailable as the Kings prepare to start their regular season Oct. 7 against the San Jose Sharks.
Complicating matters, he is still recovering from surgery for a torn Achilles' tendon and the league still needs to conduct its investigation into the domestic violence incident.
So the uncertainty over the futures of Voynov and Richards will keep the Kings in limbo for the foreseeable future.
more on the Kings...
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
The Los Angeles Kings Should Say No To Slava Voynov
by Paul on 07/03/15 at 08:33 AM ET
Comments (6)
from Helene Elliott of the LA Times,
Those who say it's punishment enough that Voynov was suspended most of last season and must serve jail time and probation, perform community service and go through a domestic violence prevention program should focus on the nature of the incident. If the Kings give him another chance, they would be making it a "gimme" and diminish its magnitude.
Varlamova told Redondo Beach police Voynov punched her in the jaw, choked her three times, pushed her to the ground, kicked her and shoved her into the corner of a flat-screen TV, resulting in a 1.2-inch gash above her left eye. He accepted responsibility for his actions, remember? That should not be forgotten.
The Kings can terminate his contract, trade him, or keep him with the team. Here's a vote for one of the first two options.
That he's a top-four defenseman isn't reason enough to keep him. It's irrelevant. He doesn't deserve to wear their uniform and they shouldn't grant him that privilege.
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: slava+voynov
On The Mike Richards Terminated Contract
by Paul on 07/02/15 at 07:16 PM ET
Comments (2)
from Eric Macramalla at Forbes,
... However, let's assume the Kings terminated the Richards contract after learning he was arrested in connection with the unlawful possession of OxyContin.
If that's the case, expect the Kings to have a tough time upholding the termination of the Richards contract in the event the NHLPA files a grievance....
Why the uphill battle for the Kings? The reason is the NHL/NHLPA Substance Abuse And Behavioral Health Program Policy.
This Drug Policy sets out specific drug treatment protocols that must be followed in the case of an arrest or conviction related to drugs. Since it was collectively bargained between the Union and the NHL, adhering to the Drug Policy is not optional for teams; it's mandatory. For example, a team cannot simply elect to ignore the collectively bargained terms for the sake of convenience. The whole idea behind the Drug Policy is to get players the help they need. The focus of the Drug Policy is ultimately rehabilitative and not punitive.
Any departure from collectively bargained terms may be met with a grievance.
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: mike+richards
Los Angeles Kings Statement On Slava Voynov
by Paul on 07/02/15 at 05:17 PM ET
Comments (2)
LOS ANGELES – Earlier today, Slava Voynov entered a no-contest plea to a single misdemeanor, domestic violence charge. The Los Angeles Kings have issued the following statement relating to this development:
"We believe the legal system has effectively resolved this matter and the punishment is fair and just. Any act of domestic violence is unacceptable. As an organization, the prevention of domestic violence and the education of our players and employees is of paramount importance. We will continue to actively develop and implement a strategy to deliver this message. We remain steadfast in our support of the National Hockey League as they now begin their own investigative process. Until that is complete we will withhold further comment."
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: slava+voynov
Slava Voynov Plea Deal
by Paul on 07/02/15 at 02:45 PM ET
Comments (10)
added 2:50pm, more via Hammond tweet,
DA says conviction will result in Voynov deportation. Defense is objecting to that, saying it is not mandatory. Some debate.
Judge clarifies that possible Voynov deportation is a matter for immigration court, not this court.
added 2:52pm, Hammond...
Judge has accepted plea agreement.
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: slava+voynov
The Latest On Mike Richards
by Paul on 06/30/15 at 11:21 AM ET
Comments (10)
from Katie Strang of ESPN,
Mike Richards, whose contract has been terminated by the Los Angeles Kings, is part of an ongoing investigation by the Royal Canadian Mounted Police for an off-ice incident, a source told ESPN.com on Tuesday.
A spokesperson for the RCMP in Manitoba told ESPN that, as of Tuesday, no charges have been brought against Richards but declined to comment further.
The source said that Canadian Border Services is also involved in the investigation, but a spokesperson declined comment, citing Canadian privacy laws.
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: mike+richards
Los Angeles Kings Terminate The Contract Of Mike Richards
by Paul on 06/29/15 at 02:34 PM ET
Comments (13)
LOS ANGELES -- The Los Angeles Kings have terminated the contract of forward Mike Richards, the club announced today.
The club has issued the following statement and will not comment any further at this time:
"The Los Angeles Kings today have exercised the team's right to terminate the contract of Mike Richards for a material breach of the requirements of his Standard Player's Contract. We are not prepared to provide any more detail or to discuss the underlying grounds for the contract termination at this time."
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: mike+richards
LA Kings Have Interest In Signing Andrej Sekera And Drew Stafford Still Talking With Winnipeg
by Paul on 06/29/15 at 01:14 PM ET
Comments (0)
from Pierre LeBrun of ESPN,
- The Kings still have interest in re-signing UFA blueliner Andrej Sekera and perhaps with the Mike Richards buyout they can find enough cap space to do so. But if not, it's believed 10 teams have shown interest.
- Drew Stafford's agent Steve Bartlett said Monday morning that he continues to talk with the Winnipeg Jets but doesn't have a deal done. Stafford was a good fit there as a trade deadline pickup but finding the right parameters to stay put is always a challenge. Still, I hope this one gets done, sometimes the fit is more important than just making as much money as possible. Stafford looks good on that roster.
many more updates during this busy time...
Filed in: NHL Teams, Los Angeles Kings, Winnipeg Jets, | KK Hockey | Permalink
About To Be Bought Out
by Paul on 06/28/15 at 12:11 PM ET
Comments (3)
added 12:23pm,
Filed in: NHL Teams, Anaheim Ducks, Los Angeles Kings, Montreal Canadiens, | KK Hockey | Permalink
The Milan Lucic Trade
by Paul on 06/27/15 at 08:36 AM ET
Comments (0)
from Lisa Dillman of the LA Times,
Kings General Manager Dean Lombardi's big moment came away from the draft floor with the Lucic trade.
"I do think every player on our team just grew three inches and put on 10 pounds of muscle," Lombardi said Friday on a conference call. "So that don't hurt."
The Bruins also will pick up $2.75 million of Lucic's $6-million salary for next season, no small issue in a world constrained by salary caps. Boston drafted Lucic, and he won a Stanley Cup with the Bruins in 2011 but realized his days with the rebuilding organization were numbered when he started hearing trade rumors.
"I had a lot of mixed emotions in the last 48 hours," Lucic said in a telephone call from Kelowna, British Columbia. "I kind of had that nervous, anxious, excited, sad, all-in-one feeling, going on in my stomach this morning. Like something big was going to happen."
Lombardi, whose team missed the playoffs this past season after winning the Stanley Cup in 2014, looked at his organizational charts and boxes and seized the chance to check the power-forward/left wing box.
"It's the Clark Gillies, Bryan Trottier, Mike Bossy-type trio that most people think is the ultimate-type line," Lombardi said of the Islanders icons. "We also wondered whether Gabby [Marian Gaborik] was better on the right [wing].
"To get a player like Clark Gillies, there's not many like this in the league, that can play with top players and bring that element."
Filed in: NHL Teams, Los Angeles Kings, | KK Hockey | Permalink
Tags: milan+lucic
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About Kukla's Korner Hockey
Paul Kukla founded Kukla's Korner in 2005 and the site has since become the must-read site on the 'net for all the latest happenings around the NHL.
From breaking news to in-depth stories around the league, KK Hockey is updated with fresh stories all day long and will bring you the latest news as quickly as possible.
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- Paradise 3 Bedroom Oceanfront Condo - 6Q (Y6)
- Paradise 3 Bedroom Oceanfront Condo - 4Q 1K (Y4)
- Paradise 3 Bedroom Oceanfront Condo - 6Q (Z)
Breakers Boutique North Tower 27th Ave.
- Boutique Ocean View Room (A)
- Boutique Ocean View Deluxe Room (B)
- Boutique Oceanfront Room (C)
- Boutique Oceanfront Efficiency (CE)
- Boutique Oceanfront King Suite (D)
- Boutique Oceanfront Queen Suite (E)
- Boutique Oceanfront Deluxe Queen Suite (F)
- Boutique Oceanfront Deluxe King Suite (G)
- Boutique 2 Bedroom Oceanfront Deluxe Condo (H)
Sailfish Tower
Palms Building
- Palms Ocean View Room (R)
- Palms Founders King Suite
- Palms Founders Ocean View Queen Suite
- Palms Ocean View Suite- ACC (N)
- Palms Ocean View King Spa Suite (NSPA)
- Palms Ocean View King Suite (Q)
- Palms Ocean View Suite (P)
- Palms Oceanfront King Suite (O)
- Palms Oceanfront Suite (O)
- Palms 2 Bedroom Ocean View Suite - 1K 2Q (S)
- Palms Founders Deluxe 2 Bedroom Condo
Palmetto Building
- Palmetto Resort View Room (L)
- Palmetto Resort View Efficency (LE)
- Palmetto Ocean View Room (K)
- Palmetto Ocean View Efficiency (KE)
- Palmetto Oceanfront Room (J)
- Palmetto Oceanfront Efficiency (JE)
- Palmetto Ocean View 2 Bedroom Condo (T)
- Palmetto 4 Bedroom Penthouse


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A sometimes-heated dispute over wasteful spending, budget deficits and a lack of transparency took center stage Thursday afternoon in Canton as a probing Wayne County committee lobbed its frustration at county administration officials.
Residents and government officials packed a township hall meeting room as the Wayne County Commission's Ways and Means Committee brought its latest session to Canton, capturing attention as the panel sought to rein in spending for a county mired in debt.
"I think this is a very good idea — the more transparency, the better for us," ...


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Ford F-250
Hi, I was wondering if you had any information on why my 1993 Ford f250 3/4 ton's front brakes are not fully releasing? It will come to a complete stop without use of the break pedal. I have replaced the left caliper, both lines, master cylinder, and booster. But yet the pads are always rubbing, and then will result in smoking from both the calipers. I would greatly appreciate any info regarding this matter. Thank you.
January 11, 2007.
January 11, 2007.
You need to check and or adjust your brake booster rod it sounds like its to far out try turning it in just a little
Jan 11, 2007.
Jan 11, 2007.
Is it correct Brake system bleed sequence on 2003 pontiac montana? Rear right - Left front - Rear Left - Right front Start with the car on level ground, engine OFF, lifted safely ...
8 answers • 2003 Pontiac Montana • 70,000 miles
Dealer fixed coolant leak with replacement of intake manifold set paid for $760, but they created 2 dash board signals, Low Brake Fluid signal and Brake signal on the dash board. I ...
17 answers • 2003 Pontiac Montana • 74,000 miles
I recently bought a 1999 Lexus RX300 that seems to not have been maintained well for the past few years. I am having issues with it not braking, automatically accelerating and suddenly ...
3 answers • 1999 Lexus RX 300 • 215,000 miles
Are any special tools required to change disc brakes on 2004 Cadillac ESV?
1 answer • 2004 Cadillac Escalade Esv • 97,800 miles


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Home > Indexes > Brother > TN350
Click image to enlarge or see more views.
UPC Code: 012502612346
Provantage Code: BRTS03X
Printing > Printer / Copier Consumables > Toner / Cartridges / Ribbons
TN350 Black Toner Cartridge
Purchase at least 10 Brother hardware products.
Shop with confidence! Provantage is an authorized Brother dealer.


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With a durable fiberglass shell and your choice of Black or Red canvas seat and cushion, the Pod Chair features an iconic futuristic design perfect in any modern setting.
Product Dimensions:
Width: 42.5"
Depth: 42.5"
Height: 47"
Seat Width: 25"
Seat Depth: 20.5"
Seat Height: 18"
$208.00 - Sold Out
The Legacy Bar and Counter Stool are a modern reproduction from Harry Bertoia's classically designed 1952 Bertoia Seating Collection. Features a sturdy chrome steel frame and your choice of Black or White faux leather cushionCounter Stool Size: 21" W x 22" D x 36.5" HSeat Height: 24" from ground / Depth 19"Foot Rail: 9.5" from groundBar Stool Size: 21.5" W x 22.5" D X 41" HSeat Height: 28.5" / Depth...
Adorn your bedroom with the striking Prince Platform Bed. Its strong appearance features a tall, leather panel tufted headboard standing five feet tall.Tapered leather side rails and footboard complete the bed. With its trim proportions, the Prince can perfectly accommodate limited space rooms.Low profile chrome feet finish its modern appearance perfectly. The mattress sits snuggly atop a solid pine-slat base for stylistic durability and added comfort. Assembly required; Mattress not...
The Chelsea Bed is a fine example of skilled artisan handwork and sophisticated design. Features a neatly tailored leather headboard, with middle seam line and clean side folds.Rounded polished steel base. Flexible European wood slats sit inside the bed frame and allow air to circulate beneath the mattress.No box spring necessary; simply use an innerspring or latex foam mattress. Steel frame construction. Assembly required; Mattress not included.Queen Total Size: 69"W...


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|Teck Crack
|E1 5c
|24m, 2 pitches.
Rockfax Description
FA. Joe Brown 1958
Ticklists: The Roaches - Routes Graded List, Staffordshire Grit Challenge - Brown-Whillans Day Out, Peak Rock/7/8/Biven-Peck Partnership/1950's a Developing Decade, Joe Brown's Three-Star Grit-List, Roaches HVS Challenge.
Photo: Iain working Teck Crack Direct on a crisp winters day © climbingsimon


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October 21, 2009
Tory Squires (6-foot-4, 230 pounds) is planning to get ready for his last regular season high school game this weekend when the Squires and the Rams face off against St. Francis DeSales. Squires has also begun to hear from more and more colleges this fall and has this hidden gem been finally discovered by several college programs? ...More... To continue reading this article you must be a member. Sign Up Now!
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Mequon - Construction of a $4.4 million addition to the Ozaukee Ice Center - enclosing a second sheet of ice and seating for 1,200 spectators - was completed this week and the public is invited to an opening party Friday.
A high demand for ice time from local hockey teams and skaters of all ages persuaded the Ozaukee Youth Hockey Association, owner of the center, to build the addition south of the original building, center manager Chris Donovan said.
The association has received $2.5 million in private contributions to help pay for the project. A fundraising drive is continuing with a goal of at least $1.5 million in additional donations to help lower the size of the group's remaining mortgage and put a few finishing touches on the addition, Donovan said.
Naming rights are being sold for the new rink and the entrance lobby, bleachers, locker rooms, concession stand and other pieces of the building.
Putting someone's name on a Zamboni would cost $100,000 - the penalty box, $25,000.
A grand opening party begins at 5:30 p.m. Friday with a ribbon cutting followed by skating exhibitions featuring ice dance competitors Christian Erwin and Kenzie Reid of Brookfield and national freestyle competitor Samantha Puhl of Mequon.
A free, open skate is scheduled from 6 to 7 p.m.
The puck drops at 8 p.m. for an inaugural men's hockey game. The Falcons of Concordia University Wisconsin will take on the Gusties of Gustavus Adolphus College in NCAA Division III play. Admission is free as part of the grand opening.
Everyone bringing an unwrapped toy to the center for the Kids2Kids Toy Drive between Friday and Dec. 23 will receive a free skate rental.
The ice center, at 5505 W. Pioneer Road, was built in 1996. It is located west of Green Bay Road.
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Interviews for Top Jobs at Time Warner Cable
- Customer Service Representative (87)
- Inbound Sales Representative (36)
- Direct Sales Representative (20)
- Field Service Technician (20)
- Retention Representative (18)
- Customer Care Representative (15)
- Account Executive (14)
- Technical Support Representative (13)
- Account Executive I (8)
- Tier III Tech Support (7)
- Customer Care Professional (7)
- Field Technician (7)
- Retail Sales Specialist (7)
- Sales (7)
- Retention Specialist (6)
- Direct Sales (6)
- Marketing Manager (5)
- Dispatcher (5)
- Outbound Sales Representative (5)
- Staff Accountant (4)
- Cable Installer (4)
- Intern (4)
- Inbound Sales (4)
- Manager (4)
- Customer Service Supervisor (3)
- Marketing Coordinator (3)
- Network Engineer (3)
- Financial Analyst (3)
- Tier III Technical Support (3)
- Business Analyst (2)
2 Candidate Interview Reviews Back to all InterviewsSort: Popular Date Difficulty
Account Executive Interview
The process took a week. I interviewed at Time Warner Cable in May 2012.
After applying on their website, I was contacted for a phone interview. It was similar to a recruiter as they only asked basic information and did not have complete answers to some of the questions I had about the specific position. I was then scheduled for a face to face interview with my potential manager. Appreciated his upfront demeanor and very professional. The questions were mostly about my background, why I thought my skills would translate to success, and why me. As a closing to the interview, I was asked to sell myself to them on why they should hire me.
Interview Questions
- They emphasized that you'll hear no a lot, so have a good plan in place on how you deal with rejection. Answer Question
Other Interview Reviews for Time Warner Cable
Account Executive InterviewNo OfferNegative ExperienceAverage Interview
The process took 4 weeks. I interviewed at Time Warner Cable in October 2011.
Received a call from recruiter (from out of state) who asked a few vague questions but unable to answer many of my questions. She also informed me that I would be getting a F2F interview. I was later contacted by a fairly knowledgeable recruiter who sounded like she was selling the job but at least could answer most of my questions. This "phone interview" was not scheduled ahead of time but I was given a phone number to call if I had further questions. I was later informed by email of the time and date for F2F interview. The F2F interview took place in a professional environment and I felt it went well. In fact the interviewing manager assured me I would advance to the next and final level of the interview process. About a week later I received a "dear John" letter by email informing me that I was no longer being considered for the positon. I phoned the recruiter to see if I could find out why I had been disqualified, she said she would get back with me in a couple of days but did not.....called her back and left VM......never heard back???
Interview Questions
- What is a sales quota? Answer Question
- How did you acheive sales success in your last position? Answer Question


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The trees and overgrowth have been trimmed, a new Lycee Francais banner hangs from the roof, lights are being installed, and for the first time in decades, schoolchildren will soon begin gathering at the former Priestley campus in west Carrollton in the mornings. Continue reading »
Central City pharmacy robbed at gunpoint; woman robbed in Lower Garden District
The Crescent City Pharmacy in Central City was robbed at gunpoint Monday morning, and a woman was robbed on St. Andrew Street in the Lower Garden District Monday night, New Orleans police said. Continue reading »
Owen Courreges: The one gun-control reform everyone should agree on after Lafayette
Before every great tragedy lies a series of rash policy decisions.
When 9/11 struck, we rapidly passed the Patriot Act and created the Transportation Security Administration. Provisions of the former permitted unconstitutional searches, while the latter subjected us to overly-intrusive searches executed by a frenzied, unfeeling bureaucracy.
The most recent tragedy we've experienced was on a much smaller scale, but it hit relatively close to home. On July 23, at the Grand Palace 16 movie theater in Lafayette, a man now know to be John Russell Houser fired a pistol into the crowd 20 minutes into the viewing of the Amy Schumer comedy "Trainwreck." Continue reading »
The long-shuttered, grafitti-covered former Sara Mayo hospital on Jackson Avenue is slated for redevelopment into a 211-unit, eight-story apartment complex with ground-floor restaurants and offices, neighbors learned Friday morning.Continue reading »
The Sewerage & Water Board has issued a water boil advisory for the East Bank of New Orleans. Continue reading »
Allan Katz and Danae Columbus: Entrepreneur Mike Motwani follows the Trump business model
Scrappy New Orleans entrepreneur Kishore "Mike" Motwani's $8.175 million purchase this week of Oz, New Orleans premiere gay dance club, this week is another sign that this often-despised self-made millionaire puts his money where his mouth is. Much to the dismay of ardent preservationists, Motwani is living the American Dream by remaking downtown New Orleans in his own image. Continue reading »
Advertiser's Message: Meet Saints Tight End Benjamin Watson at Dat Dog on Thursday, July 23rd – National Hot Dog Day
Saints Tight End Benjamin Watson will be the Saints celebrity dogmaker on Thursday, July 23rd from 5:30 p.m. to 6:30 p.m. at Dat Dog on Freret. Watson will dress dogs, sign autographs and greet fans to raise money for Son of a Saint, a non-profit organization that enhances the lives of fatherless boys, providing guidance through mentors.
Letter to the editor: Data, history support medical uses for marijuana
By Brendan Valentine, David Brown and Kevin Caldwell
According to Dr. Ken Roy, the passage of Louisiana's Senate Bill 143 is "a sad day for science, a sad day for medicine and a sad day for the State of Louisiana." Dr. Roy is concerned that it isn't currently feasible to expect physicians to prescribe a Schedule I substance, due to FDA regulations. He also strongly implies that there are no legitimate therapeutic uses for marijuana in a natural form. Continue reading »
Preservationists, property owners clash over requests to demolish more Uptown houses
The debate between historic preservation and private-property rights flared again Monday as a panel of New Orleans officials considered requests to tear down four more Uptown homes, pitting preservationists against property owners and neighbors against neighborhood associations. Continue reading »
Owen Courreges: The Top 10 traffic laws New Orleans loves to break
New Orleanians have long suspected that our drivers (like our government) are completely ignorant of the law. There's some basis in fact for this view. A 2013 study found that Louisiana had the worst drivers in the country. Continue reading »
Advertiser's Message: New Orleans Digital Marketing Agency CEO Flynn Zaiger to Speak at Sage Summit 2015
New Orleans-based digital marketing agency Online Optimism is proud to announce its participation in upcoming premier business development event Sage Summit, that will be held at the Ernest N. Morial Convention Center July 27-30, 2015.
Hosted by Sage North America, a leading provider of business management software and services, Sage Summit began in 2003 as a product-training event. Last year, Sage Summit was successfully re-imagined with a mission to be the most valuable gathering for small and mid-sized businesses and accountants – with a deeper layer of thought leadership and more purposeful learning, and attendance more than doubled. This year's conference is expected to draw more than 7,500 attendees live and 15,000 virtually.
Boy, 8, injured in Annunciation Street shooting; man shot in Carrollton, police say
An 8-year-old boy inside an Annunciation Street home was hit in the foot by gunfire from outside on Saturday evening, and a 28-year-old man was shot in the buttocks overnight near Eagle Street in Carrollton, New Orleans police said Sunday morning. Continue reading »