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Grade 8 Up—In post-World War I Austria, Englishman and self-made magnate Guy Farne buys a countryside castle as part of an elaborate plan to woo Nerine, the woman he loved and lost as a penniless teenager. Meanwhile Tessa, Pfaffenstein Castle's headstrong young heiress, revels in the anonymity of life as a junior wardrobe mistress at the International Opera Company in Vienna. When Guy commissions the company to stage a production of Mozart's Magic Flute at Pfaffenstein, he and Tessa meet and bond over their love of art and music. He is unaware of her connection to his new estate until her identity is revealed at a lavish ball held to introduce Nerine to Austrian society. Though drawn to Tessa, Guy stays faithful to his deliciously snobby fiancée. In the meantime Tessa fields the dogged (and comic) marriage proposals of a local prince. Predictably, the star-crossed pair eventually get their well-deserved happy ending. The novel opens with too much telling instead of showing, but Ibbotson hits her stride once all the players assemble at the castle. Vivid details bring supporting characters to life. German phrases and literary allusions may escape young readers, but do not detract from the overall flow of the narrative. There is nothing groundbreaking here, but this is satisfactory historical romance for future fans of Philippa Gregory.—Amy Pickett, Ridley High School, Folsom, PA
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
Eva Ibbotson, born Maria Charlotte Michelle Wiesner (21 January 1925 – 20 October 2010), was an Austrian-born British novelist, known for her children's books. Some of her novels for adults have been successfully reissued for the young adult market in recent years. For the historical novel Journey to the River Sea (Macmillan, 2001), she won the Smarties Prize in category 9–11 years, garnered unusual commendation as runner up for the Guardian Prize, and made the Carnegie, Whitbread, and Blue Peter shortlists. She was a finalist for the 2010 Guardian Prize at the time of her death. Her last book, The Abominables, was one of eight books on the longlist for the same award in 2012.
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I wish I had never read this, so I could experience again the transporting joy of reading it for the first time. Read morePublished 7 months ago by James Kenney
I liked this book, although it wasn't her best. I sort of thought that it was a waste of time, but I like the plot. It was the characters. Read morePublished 10 months ago by Selena#1
Didn't love this one. Maybe I'm getting burnt out on Ibbotson's class issues, but I think Countess Below Stairs was the best of the lot and this one just didn't measure up.Published 15 months ago by November
Princess Theresa-Maria was an heiress in Austria in the 1920's but now she is without a fortune and a title. Read morePublished 18 months ago by Maude Estee
Interesting. Most of her books are similar stories but easy to read and interesting about English culture. I have four of them.Published 19 months ago by Ruth A. Unks
Same grandmother, another child. Emily is a wonderful fourteen year old who reads a lot, mostly digital on her I Pad. Read morePublished 22 months ago by Marion A. Knott
I LOVE the author Eva Ibbotson, but I feel of all her books, this one mostly contains recycled plot material from other books and lacks the depth in the romance of her other... Read morePublished on June 9, 2013 by Amazon Customer
I read this book after reading Ibbotson's other book, "The Secret Countess." Perhaps it is just because I read another one of this book style from her, but to me it seemed... Read morePublished on November 11, 2012 by Brain_Byte
I'm about halfway through this novel. I picked it up as part of an effort to broaden the genres I read (I've never read anything that could be counted as either historical or... Read morePublished on July 22, 2011 by La Luna Unita


text: Home Recipes Ingredients Pork Recipes Pork Main Dishes Share: Pork Main Dishes Looking for pork main dishes? Find pork main dishes including pork chops, pork ribs, pork casseroles, and more pork main dish recipes. Recipe Spotlight Southwest Shredded Pork Salad Mary Shivers of Ada, Oklahoma, makes a knockout shredded pork, served in tortillas. Turn it into a hearty salad of pork, greens, black beans and other Southwestern sprinklings. —Mary Shivers, Ada, Oklahoma View Southwest Shredded Pork Salad Recipe More Pork Main Dishes Sort: Highest Rated Alphabetical Contest Winning Newest < prev | 1 | 2 | 3 | 4 | 5 | ... | next > Hash Brown Sausage Bake Hash Brown Sausage Bake "This is one of my son's favorites," Vicky Dempsey says from Louisville, Mississippi. Buttered hash browns form a mouthwatering crust for yummy filling of sausage and cheese. It's sure to please at breakfast, brunch or even lunch. View Recipe Pork Tenderloin with Gravy Pork Tenderloin with Gravy "I recently began experimenting with pork and came up with this easy dish, which has turned out to be a favorite," writes Marilyn McGee of Tulsa, Oklahoma. "I like to vary it occasionally by using lemon-pepper or garlic-seasoned tenderloin for added flavor." View Recipe Pork Chops with Honey-Balsamic Glaze Pork Chops with Honey-Balsamic Glaze My husband loves pork chops, so I try to find new ways to use them. He calls this version "restaurant quality!" —Nicole Clayton, Prescott, Arizona View Recipe Advertise with us ADVERTISEMENT Tangy Pork Chops Tangy Pork Chops Fancy enough for company, these mouthwatering pork chops also make a great family meal. I usually have all the ingredients on hand. Since my husband and I just had our first child, this recipe is so convenient—I start it during naptime for a no-fuss supper later.—Karol Hines, Kitty Hawk, North Carolina View Recipe Favorite Grilled Pork Chops Favorite Grilled Pork Chops I start preparing this entree the night before I plan to grill it. It's a fabulous marinade with a unique flavor, and is of the only ways our family eats pork chops. —Erica Svejda, Janesville, Wisconsin View Recipe Pork Schnitzel with Dill Sauce Pork Schnitzel with Dill Sauce Schnitzel is one of my husband's favorites because it reminds him of his German roots. An appealing dish for guests, it's ready in a jiffy. —Joyce Folker, Paraowan, Utah View Recipe Pork Chops In Gravy Pork Chops In Gravy "A good friend made me these tender chops in a flavorful gravy for my birthday," recalls Meg Griesdorn of Murraysville, West Virginia. "I immediately asked for the recipe and have served them many times since. There are never leftovers," she reports. View Recipe Savory Pork Roast Savory Pork Roast I love this herbed roast so much that I make it as often as I can. It's wonderful for special occasions, particularly when served with sweet potatoes and corn muffins. —Edie DeSpain, Logan, Utah View Recipe Tuscan Pork Medallions Tuscan Pork Medallions Pork tenderloin gets delightful Italian flavor from prosciutto, tomatoes and garden herbs. The beautifully browned slices are quick enough for weeknights yet will impress your guest. —Lorraine Caland, Thunder Bay, Ontario View Recipe Jalapeno Ribs Jalapeno Ribs These ribs are unique because of the spicy rub and the combination of sweet brown sugar and spicy jalapeno peppers in the sauce. I always make them for my husband's birthday. —Shirley Manthey, Omaha, Nebraska View Recipe Bruschetta Pizza Bruschetta Pizza You might need a knife and fork for this hearty pizza! Loaded with Italian flavor and plenty of fresh tomatoes, it's bound to become a family favorite. It's even better with a homemade, whole wheat crust! —Debra Kell, Owasso, Oklahoma View Recipe < prev | 1 | 2 | 3 | 4 | 5 | ... | next > Advertise with us ADVERTISEMENT Advertise with us ADVERTISEMENT

subset: commoncrawl


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001Micron Sim Card Data Recovery
editor's review
1 comment
buy now $79.00
001Micron Sim Card Data Recovery is a software solution that enables users to easily restore all items stored in your SIM card, including messages, contacts and dialed numbers.
Well-organized layout
The installation process does not pose any kind of issues, and it is over in a jiffy. After completing it, you are met with a pretty minimal interface, seeing it consists of a few buttons, a navigation panel and another panel in which to display the selected information.
Well-written and extensive Help contents are incorporated, which ensure that all types of users can easily find their way around this program, without encountering any kind of difficulties.
Information you can recover and technology supported
As stated above, this tool enables you to recover files from your SIM card. This is possible by using a Phoenix technology standard, as well as a PC/SC one, and setting up 001Micron Sim Card Data Recovery to search for your SIM, with just a click of the button.
In a folder structure in the main window, it is possible to view all the type of information you can gather, namely SMSs, your address book, last dialed numbers, service provider name, card identification, location, IMSI, forbidden and user PLMN (Public Land Mobile Network) and your own phone number.
However, you should know that saving the information to the hard drive is not possible in the demo version, which is considered to be quite a significant drawback.
A final evaluation
It does not burden the system's performance as the requirements for this tool are quite insignificant, yet the response time is not particularly good. The interface is suitable to all users, yet it could benefit from a "facelift."
Taking all of this into consideration, we can safely say 001Micron Sim Card Data Recovery is an efficient piece of software when it comes to retrieving information you lost from your SIM card.
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Our new "How to Study the Bible" series starts soon! Sign up today.
1:1–2:3 This account of creation lays the foundation of Israel's world view about God, human beings, creation, and the laws that pertain to mankind (e.g., to worship no other gods, to keep the Sabbath, and to take no innocent life).


text: We did a 2 week road trip in California in Aug 2013. Pacifica Suites was far from our most expensive accommodation, but it was by far the best place we stayed. All in our party loved the freshly made to order breakfast that was included. The omlettes were delicious. We also took advantage of the free wine tasting 2 nights in a row and enjoyed the pool after hot days exploring Santa Barbara. Rooms were clean and spacious. All staff were friendly and very accommodating.


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Analysis: Welsh Scot
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"The card design is super cute! I just wish I would have used a darker pink for the font at the bottom of the card as it's a little hard to read but other than that, I love the simple design and the card quality."
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"Overall I was very pleased with this card. I read the reviews before I purchased it so I knew to expect the texture verses a flat card; however, even though the paper wasn't completely smooth, I didn't have a hard time writing on it at all. It has the perfect coloring for what I was looking for, and it looks just like the picture available on the webiste. Also, it is the perfect size for a thank you card with just the right amount of space to write."
"This card was more beautiful in person. The colors are bright and cheery. I'm using them as thank you cards for presents for our new baby and have received many compliments."
"these cards are so cute! I have received so many compliments on these cards and almost every person ask about them as soon as they receive my thank you note. they are the perfect size. i also got the back with the 5 color strips and that also is lovely! printing is perfect!"


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- Product Information
Product Description
Hit the jackpot at your Vegas style party with our 15" cascade slot machine centerpiece. Our slot machine centerpiece is sold by the piece. Please order in increments of 1 piece.
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- Attractive Design, Easy To Use, Fun, Col Review by Lorraine
Attractive Design, Easy To Use, Fun, Colorful
(Posted on 8/13/12)
- A little small Review by Party Planner
[...] Too small for a centerpiece and I am a little dissapointed. Just got to make the best if it I guess.
(Posted on 7/25/11)
Write Your Own Review
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Good if pricey, well located.Beds overly soft - loved by some, hated by others.
So, we didn't actually stay here. My girlfriend/long lost cousin and I took the kids out for breakfast after church (we are ex-pats living in Nairobi) and got to restaurant at 11:15, 15 mins after they stopped serving breakfast. The staff were cordial but rigid that we couldn't order anything but would have to wait 45 minutes for brunch. The prospect wasn't all together appealing so we asked to see the manager . After a short discussion. he set us up in the coffee area, assigned the charming, Michael to wait on us and 15 minutes later we were tucking into well made beautifully presented dishes. The kids cleared their plate (always a good sign) and I ate most of my muesli served in a huge red wine glass with what tasted like home made yogurt. Michael was very attentive and the manager returned once to find out how we were getting on. There was a slight lapse in service between courses but on the whole the staff were warm and efficient. I questioned them closely about the muesli mix and they must have thought I was potty. However for those of us with sensitive stomachs it's important to know what's in a dish. Alas I have suffered all day from IBS and I can blame it squarely on the muesli. However as a goodwill gesture they had not charged us for it, so I won't deduct a star either for my stomach ache! It was a nice outing although being Sankara, rather pricey.
This was my first time staying at the Sankara Hotel in Westlands. I have stayed in a number of hotels in Nairobi including Tribe and Serena, but this one has the best rooms by far. The rooms are larger, the beds are bigger, the bathrooms are spacious, and with satelittle tv. There is a nice poolside bar upstairs where you can have wine, cocktails, tapas, or shisha. There is a gym which is fine for cardio but could use some heavier weights. The hotel restaurant is very good and features a really good breakfast with a mix of Indian, Kenyan, and other foods. Cybercafe with several computers provided to guests with no charge. If no traffic, it is ten minutes away from the UN Regional headquarters, and a number of embassies including the U.S. Embassy. I plan to stay in this hotel during future trips to Nairobi.
In my 20+ reviews I've never written one as good as this.Look, it's expensive. It's eight times the price of the hotel I stayed in last night. But I returned here, having stayed last weekend also, because it's just unbelievably good.Rooms are modern and immaculate with not a scuffmark on them. The window in the bathroom to allow you to watch telly in the bath (with in-bathroom volume control) reminds me of the Westin Sydney which was my favourite hotel a decade ago. Bed is unbelievably comfortable, doing that trick that refurbished Marriotts do of having an under-duvet/comforter, but it seems like there's memory foam in there somewhere too.But it's the service here that gets to you. Everyone you meet seems genuinely friendly and helpful. I stay in dozens of hotels a year, but I only see this service perhaps once every two or three years - Taj Goa, Ritz-Carlton St Louis, Imperial Delhi, Gritti Palace Venice are other hotels I can remember that also exhibit this friendly understated excellence.I came back from a late lunch to find my bed being stripped and all the linen replaced as they were performing a turndown service with slippers - I only checked in at lunchtime today and had dozed for a couple of hours. A call for a shaving amenity kit was answered within one ring, and turned up within two minutes.The rooftop bar is amazing. Great place to take a date, or just hang out alone. There's a small pool there too, if you like that sort of thing. The gym looks amazing too - I really should go.If you're looking for a top-class hotel outside of the big chains which in Nairobi appear to be trading on their global reputations hawking tired old rooms and lousy service, then your choices really come down to Sankara in Westlands and Tribe in Village Market (which is way off the beaten track, and only much use to you if you have business at the UN). I've stayed at both, and in fairness I think Tribe's rooms are slightly better (although at Tribe you'd better know your partner very well, as the toilet is open-plan to the bed). But on service there's absolutely no contest: Tribe's service was mediocre at best, whereas Sankara is truly world class.
a perfect oasis of pure luxury and outstanding service in Nairobi. Most certainly the best !
Probably the most enjoyable stay of many in Nairobi. And if you judge a property as to how they cope with a problem - and we had one - then I thought they coped admirably. I've never really liked any hotel in Nairobi a lot but I found the Sankara to be good and comfortable and I shall be back their next month. A very pleasant experience.
This is by far the most modern and best hotel. The service is great. Looked in a part of city where it is ok to walk you'll love staying here. Free WIFI and internet make it a great deal. The food isnt great but passable.
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April 5, 2013
My name is José Supico, I'm co-founder of ScaleStar, an online investment platform that aims to democratize access to top financial advice and products. Our customers are UK Financial Advisers that want to serve clients with small to medium savings.
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"Because sometimes it's nice to be reminded."
"A mantra for anyone feeling like they might lose themselves in marriage (or otherwise)."
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"Downtown Miami" Top 5 Page for this destination Down Town Tip by cobrioc
Down Town, Miami: 11 reviews and 14 photos
Favorite thing: Miami's downtown skyline is considered one
of the nation's most beautiful, or at least most colorful.
At night , the towering skyscrapers are lit in neon , and most unmistakable symbol of downtown is the NationsBank Tower.
Fondest memory: Nationsbank Tower , other funky downtown neon lighting comes from the Metromover's rainbow illuminated 4,4- mile track, which makes a circuit of downtown.
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Pikachu's Plight Rated 4.0343 Stars Pikachu and his buddy Squirtle take a moment to relax Comedy - Parody Pico gets high Rated 1.3896 Stars Pico gets high in his NY flat. Advenntuers Of Mareo Man Rated 4.3964 Stars MAREO GOS ON A ADVENNTUER!!!1 The Law Offices of Maybe and I Dunno Rated 2.8367 Stars Sleepycast Animated: Parody of Lawyer Commercials Comedy - Parody
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The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn't been seen before.
Discuss the article on the Forums.
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Discussion in 'XMRV Testing, Treatment and Transmission' started by VillageLife, Aug 23, 2010.
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Friday, September 18, 2015
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Each weekday, 99.5 WCRB brings you a symphonic masterpiece, providing a bookend to the day and a prelude to the evening. And as the academic year gets underway, our Symphony at 8 features performances from the New England Conservatory of Music and Director of Orchestras Hugh Wolff.
Hear Hugh Wolff's reflections on his work at NEC and each individual symphony in this series above, and for information about the coming season of free concerts, visit the New England Conservatory.
The five symphonies you'll hear represent not only the core of the orchestral repertoire, but also a range of particular emotional experiences for listeners. Those qualities, combined with the kinetically charged energy of the musicians of NEC, add up to create performances of unusual magnetism, all recorded in concert at NEC's Jordan Hall. The series includes
Monday, June 8, 2015
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The 2015 Rockport Chamber Music Festival marks the fifth anniversary of the opening of one of New England's most stunning concert halls, the Shalin Liu Performance Center. Before 2010, festival concerts took place in the charming if cramped galleries of the Rockport Art Association. To say that the Shalin Liu is a step up as a concert space is to vastly understate its importance. With an on stage window looking out to Sandy Bay and its intimate acoustics, the hall has become an integral part of the cultural landscape not only of the North Shore but of the entire region.
This summer's festival began with a gala concert by Yo-Yo Ma, followed in quick succession by two appearances by the Shanghai Quartet, the second including a performance with festival Artistic Director David Deveau in the Piano Quartet in G minor, Op. 25, by Brahms. WCRB brings you highlights of those concerts on Sunday, June 14, at 7pm.
The festival continues through August 1, when pianist Benjamin Grosvenor visits Rockport with a program of works by Mendelssohn, Bach-Busoni, Ravel, and more. You can see Grosvenor in action below in a visit to WCRB's Fraser Performance Studio.
The festival also includes appearances by pianist
For complete information, visit Rockport Music.
Wednesday, May 13, 2015
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Tuesday, March 17, 2015
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No composer has had as deep and enduring an effect on music and wider culture than J.S. Bach. Born in the small town of Eisenach in the German region of Thuringia on March 21, 1685, each stage of his life resulted in timeless masterpieces that continue to speak to audiences today. Join us at 99.5 WCRB on Sunday, March 29, to celebrate that legacy with two of Bach's most monumental works of sacred music.
Sunday, March 29, 3pm: The St. Matthew Passion, live with the Handel and Haydn Society
WCRB takes you live to Symphony Hall for one of the signature events of the bicentennial season of the Handel and Haydn Society. Artistic Director Harry Christophers leads this pinnacle of Bach's musical achievement, a piece performed for the first time in the U.S. by the Handel and Haydn Society in 1879. Tenor Joshua Ellicott sings the role of the Evangelist, with baritone Roderick Williams in the role of Jesus. Additional soloists include
See a translation of the St. Matthew Passion
See Harvard University Bach scholar Christoph Wolff's introduction to the St. Matthew Passion:
Hear a guided tour of the St. Matthew Passion with Harry Christophers on The Bach Hour
Sunday, March 29, 7pm: The St. John Passion, in concert with Emmanuel Music
Ryan Turner leads the chorus and orchestra of Emmanuel Music in Bach's St. John Passion, with tenor Matthew Anderson in the role of the Evangelist and baritone Dana Whiteside in the role of Jesus. Additional soloists include
See a translation of the St. John Passion
Hear a preview of the St. John Passion with Ryan Turner and WCRB's Brian McCreath:
Tuesday, February 24, 2015
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Tuesday, August 14, 2012
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text:
|Publication number
|Publication type
|Application number
|Publication date
|1 Feb 2007
|Filing date
|3 May 2006
|Priority date
|29 Jul 2005
|Publication number
|Chun-Yi Chang
|Original Assignee
|Hon Hai Precision Industry Co., Ltd.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (21), Referenced by (8), Classifications (5), Legal Events (1)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to heat dissipation devices and, more particularly, to a fins-type heat sink.
At present, electronic components such as semiconductor chips are becoming progressively smaller, while at the same time heat dissipation requirements thereof are increasing. Generally, heat dissipation devices are applied to the electronic components in order to facilitate radiation of heat from the electronic components.
Numerous kinds of heat dissipation devices have been developed for cooling down the electronic components, for example, heat sinks. A conventional heat sink includes a base and a number of fins extending from a surface of the base. In general, the base and the fins are separately formed, and are then joined together. There are two typical ways to join the fins and the base together. One way is to employ a thermal adhesive, an epoxy resin or the like between the fins and the base, whereby the base and the fins are in effect indirectly joined together. The other way is to employ forging pressing, melting, soldering or the like to in effect directly join the fins and the base together.
A typical soldered fin heat sink assembly can be formed by the steps of: placing a sheet or paste of Sn—Zn (tin-zinc) solder upon a copper base; placing a folded aluminum fin assembly on the solder sheet or paste; heating the base, the folded fin assembly and the solder to a temperature exceeding the liquidus temperature of the solder, and allowing the solder to flow; and cooling the solder to form a soldered joint between the base and the folded fin assembly.
However, the soldering process is relatively complicated and time-consuming. In addition, the interposed solder causes thermal resistance between the base and the fins. As a result, the heat transfer efficiency of the heat sink assembly is relatively lower.
Additionally, typically, the heat sink employs solid base and fins. This solid base and fins unduly have a heavy weight and thus are unsuitable for a lightweight requirement of current electronic products.
What is needed, therefore, is a heat sink which is lightweight and has relatively lower thermal resistance.
In accordance with a preferred embodiment, a heat sink includes a base, a plurality of fins, and a working fluid. The base defines a receiving space therein. The fins extend from the base. Each fin defines a cavity in communication with the receiving space of the base. The working fluid is hermetically contained inside the receiving space.
Other advantages and novel features will become more apparent from the following detailed description of embodiments when taken in conjunction with the accompanying drawings.
Many aspects of the present heat sink can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale, the emphasis instead being placed upon clearly illustrating the principles of the present heat sink. Moreover, in the drawings, like reference numerals designate corresponding parts throughout the several views.
Embodiments of the present heat sink will now be described in detail below with reference to the drawings.
The base 10 includes an upper enclosure 14 and a lower substrate 16. The upper enclosure 14 and the lower substrate 16 cooperatively define the receiving space 12 therein. The upper enclosure 14 and the lower substrate 16 advantageously have an essentially similar thickness and are made from a similar material. The upper enclosure 14 has a top portion 14 a and a plurality of side portions 14 b. The fins 20 extend from the top portion 14 a of the upper enclosure 14. Alternatively, the base 10 could be a hollow integral enclosure.
An opening 17 is advantageously defined on one of the side portions 14 b of the upper enclosure 14. The opening 17 is usefully configured for introducing/discharging the working fluid 30 into/off the receiving space 12. Further, the receiving space 12 advantageously has lower pressure than outside environment around the heat sink 1. Thus, the opening 17 is beneficially used to vacuumize the receiving space 12 to attain a predetermined low pressure. The pressure is advantageously in the approximate range from 1.3�10−4 Pa to 1.3�10−1 Pa. A sealing member 18 is beneficially applied to the opening 17, for sealing the opening 17. The sealing member 18 could be, e.g., a bolt or a screw.
The fins 20 could be in a variety of forms, such as, for example, a micro-fins type, an annular type, or a spiral type. The fins 20 each include sidewalls 21. Each sidewall 21 and the top portion 14 a of the upper enclosure 14 are advantageously configured as a whole, for example, by an injection molding method.
Each sidewall 21 of each fin 20 advantageously has a similar thickness to the upper enclosure 14 and the lower substrate 16. This thickness is substantially in the approximate range from 5 millimeters to 10 millimeters. The cavity 22 of each fin 20 has a narrow width W in the approximate range from 1 millimeter to 10 millimeters. A space between adjacent fins 20 is in the approximate range from 1 millimeter to 10 millimeters. The fins 20 and the base 10 are advantageously comprised of a similar material, for example, a thermally conductive material selected from the group consisting of: copper, aluminum, nickel, iron, alumina, aluminum nitride, and combinations thereof.
A wick 24 is advantageously applied to an inner surface of each sidewall 21 of the fins 20, for drawing and introducing the working fluid 30 toward the receiving space 12 via a capillary attraction thereof. The wick 24 could be in a form of, e.g., a wick structure layer or a wick material stuffed in the cavity 22. The wick 24 could be made, beneficially, from a porous material, such as, for example, carbon fibers, carbon nanotubes, sintered copper powder, or micro etched grooves. Further, the wick 24 could, optionally, also be applied to the receiving space 12, i.e., formed on an inner surface of the receiving space 12 or stuffed into the receiving space 12.
The working fluid 30 is beneficially a liquid having properties, such as, high phase change latent heat, good fluidity, steady chemical characteristics, and low boiling point. The working fluid 30 could, advantageously, be comprised of a liquid selected from the group consisting of water, methanol, alcohol, acetone, ammonia, heptane, etc.
The working fluid 30 has preferably a plurality of nano-particles suspended thereinto, for improving thermal conductivity thereof. The nano-particles could, advantageously, be comprised of a thermally conductive material, e.g., carbon nanotubes, carbon nanocapsules, nano-sized copper particles, or any suitable combinations thereof. The nano-particles beneficially occupy about 0.5 to 2 percent by weight in the working fluid 30.
In operation, heat generated from the heat-generating element 3 firstly is transferred to the lower substrate 16 of the heat sink 1 via the thermal interface material 5. Then, the working fluid 30 is vaporized and sequentially attains the cavities 22 of the fins 20. In the cavities 22 of the fins 20, the vapor working fluid 30 goes through a sequential phase change and thereby is condensed into liquid working fluid 30 due to a cooperative cooling action of the fins 20 and the fan 2. The liquid working fluid 30 is drawn back to the receiving space 12 via a capillary attraction of the wick 24 thereby effectuating a heat transfer cycle of the heat sink 1.
Because the combined receiving space 12 and the cavities 22 are vacuumized at a lower pressure, the working fluid 30 is readily vaporized in the receiving space 12 and promptly flows through the cavities 22 of the fins 20. Accordingly, the heat sink 1 inside produces relatively little thermal resistance thereby promoting the thermal efficiency of the heat sink 1. The heat sink 1 can also uniformly cool down the heat-generating element 3 due to a uniform evaporation and fluidity of the working fluid 30 thereby preventing an occurrence of a partial overheating in the heat-generating element 3.
Furthermore, the heat sink 1 includes the vacuumized cavities 22 and receiving space 12, so the entire heat sink 1 is efficiently lightened enough to satisfy a lightweight requirement of current electronic products. Moreover, the opening 17 could provide convenient for introducing or refreshing the working fluid 30, and changing the vacuum degree in the combined receiving space 12 and the cavity 22.
It is believed that the present embodiments and their advantages will be understood from the foregoing description, and it will be apparent that various changes may be made thereto without departing from the spirit and scope of the invention or sacrificing all of its material advantages, the examples hereinbefore described merely being preferred or exemplary embodiments of the invention.
|Cited Patent
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|Digital Equipment Corporation
|High performance substrate, electronic package and integrated circuit cooling process
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|Lsi Logic Corporation
|Powdered metal heat sink with increased surface area
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|Lucent Technologies Inc.
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|Method of forming a phase change heat sink
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|Intel Corporation
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|Folded fin on edge heat sink
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|Folded fin heat sink assembly
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|International Business Machines Corporation
|Cooling system and cooled electronics assembly employing partially liquid filled thermal spreader
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|Matsushita Refrigeration Company
|Portable information appliance
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|Hua Yin Electric Co., Ltd.
|Structure of a heat-pipe cooler
|5 Jan 2004
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|Industrial Technology Research Institute
|Flat heat pipe provided with means to enhance heat transfer thereof
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|Thermotek, Inc.
|Stacked low profile cooling system and method for making same
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|Hon Hai Precision Industry Co., Ltd.
|Heat pipe
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|Merck Patent Gmbh
|Use of PCMs in heat sinks for electronic components
|8 Mar 2001
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|Ulrich Fischer
|Cooling device for electronic components
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|Advanced Materials Technologies Pte. Ltd.
|Advanced microelectronic heat dissipation package and method for its manufacture
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|Mitsubishi Aluminum Co., Ltd.
|Heat pipe unit and heat pipe type heat exchanger
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|Lalit Chordia
|Methods and apparatuses for electronics cooling
|Citing Patent
|Filing date
|Publication date
|12 Sep 2006
|2 Sep 2008
|Graftech International Holdings, Inc.
|Base heat spreader with fins
|28 Dec 2006
|12 Oct 2010
|Hon Hai Precision Industry Co., Ltd.
|Infrared light emitting and receiving system
|3 Feb 2011
|17 Nov 2011
|MicroBase Technology Group
|Heat dissipation system with a spray cooling device
|20 Dec 2010
|31 May 2012
|Hon Hai Precision Industry Co., Ltd.
|Heat-dissipating device
|21 May 2012
|21 Nov 2013
|Hamilton Sundstrand Space Systems International
|Extruded matching set radiators
|21 May 2012
|21 Nov 2013
|Hamilton Sundstrand Space Systems International
|Laser sintered matching set radiators
|21 Jun 2013
|15 May 2014
|Gerald Ho Kim
|Silicon-Based Thermal Energy Transfer Device And Apparatus
|19 May 2010
|24 Nov 2011
|Eugen Wolf
|Isothermal cooling system for cooling of i.e. microprocessor of computer, has isothermal vaporization radiators with cooling fins to dissipate heat to environment, where inner cavity of fins comprises vaporization and gas portions
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|3 May 2006
Owner name: HON HAI PRECISION INDUSTRY CO., LTD., TAIWAN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CHANG, CHUN-YI;REEL/FRAME:017862/0103
Effective date: 20060425


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SBS Show "Hot Love" Press Conference In Seoul
South Korean actors Sung Hoon, Lee Won-Keun, Yoon Mi-Ra, Jeon Mi-Sun,... News PhotoActor,Arts Culture and Entertainment,Attending,Celebrities,Horizontal,Press Conference,Seoul,South KoreaPhotographer Han Myung-GuCollection: WireImage 2013 Han Myung-GuSEOUL, SOUTH KOREA - SEPTEMBER 23: (L-R) South Korean actors Sung Hoon, Lee Won-Keun, Yoon Mi-Ra, Jeon Mi-Sun, Woo Hee-Jin and Oh Dae-Gyu attend SBS Drama 'Hot Love' press conference at 63 building on September 23, 2013 in Seoul, South Korea. The drama will open on September 28, in South Korea. (Photo by Han Myung-Gu/WireImage)


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Are you Shahar Molshanski-Mor?Claim your profile
Publications (15)61.57 Total impact
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ABSTRACT: Today's arsenal of antibiotics is ineffective against some emerging strains of antibiotic-resistant pathogens. Novel inhibitors of bacterial growth therefore need to be found. The target of such bacterial-growth inhibitors must be identified, and one way to achieve this is by locating mutations that suppress their inhibitory effect. Here, we identified five growth inhibitors encoded by T7 bacteriophage. High-throughput sequencing of genomic DNA of resistant bacterial mutants evolving against three of these inhibitors revealed unique mutations in three specific genes. We found that a nonessential host gene, ppiB, is required for growth inhibition by one bacteriophage inhibitor and another nonessential gene, pcnB, is required for growth inhibition by a different inhibitor. Notably, we found a previously unidentified growth inhibitor, gene product (Gp) 0.6, that interacts with the essential cytoskeleton protein MreB and inhibits its function. We further identified mutations in two distinct regions in the mreB gene that overcome this inhibition. Bacterial two-hybrid assay and accumulation of Gp0.6 only in MreB-expressing bacteria confirmed interaction of MreB and Gp0.6. Expression of Gp0.6 resulted in lemon-shaped bacteria followed by cell lysis, as previously reported for MreB inhibitors. The described approach may be extended for the identification of new growth inhibitors and their targets across bacterial species and in higher organisms.Proceedings of the National Academy of Sciences 12/2014; 111(52). DOI:10.1073/pnas.1413271112 · 9.67 Impact Factor
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ABSTRACT: Bacterial resistance to antibiotics is an emerging threat requiring urgent solutions. Ever since their discovery, lytic bacteriophages have been suggested as therapeutic agents, but their application faces various obstacles: sequestration of the phage by the spleen and liver, antibodies against the phage, narrow host range, poor accessibility to the infected tissue, and bacterial resistance. Variations on bacteriophage use have been suggested, such as temperate phages as gene-delivery vehicles into pathogens. This approach, which is proposed to sensitize pathogens residing on hospital surfaces and medical personnel's skin, and its prospects are described in this addendum. Furthermore, phage-encoded products have been proposed as weapons against antibiotic resistance in bacteria. We describe a new phage protein which was identified during basic research into T7 bacteriophages. This protein may serendipitously prove useful for treating antibiotic-resistant pathogens. We believe that further basic research will lead to novel strategies in the fight against antibiotic-resistant bacteria.Bacteriophage 03/2014; 4(1):e28491. DOI:10.4161/bact.28491
Article: Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division[Show abstract] [Hide abstract]
ABSTRACT: Bacteriophages take over host resources primarily via the activity of proteins expressed early in infection. One of these proteins, produced by the Escherichia coli phage T7, is gene product (Gp) 0.4. Here, we show that Gp0.4 is a direct inhibitor of the E. coli filamenting temperature-sensitive mutant Z division protein. A chemically synthesized Gp0.4 binds to purified filamenting temperature-sensitive mutant Z protein and directly inhibits its assembly in vitro. Consequently, expression of Gp0.4 in vivo is lethal to E. coli and results in bacteria that are morphologically elongated. We further show that this inhibition of cell division by Gp0.4 enhances the bacteriophage's competitive ability. This division inhibition is thus a fascinating example of a strategy in bacteriophages to maximize utilization of their hosts' cell resources.Proceedings of the National Academy of Sciences 11/2013; 110(48). DOI:10.1073/pnas.1314096110 · 9.67 Impact Factor
Article: Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study[Show abstract] [Hide abstract]
ABSTRACT: In this study, the "peptide walking" approach was applied to the DH region of Nox2 (residues 288-570) with the purpose of identifying domains of functional importance in the assembly and/or catalytic function of the NADPH oxidase complex of phagocytes. Ninety-one overlapping 15-mer peptides were synthesized to cover the full length of the Nox2 DH region, and these were tested for the ability to interfere with the activation of the oxidase in vitro in two semi-recombinant cell-free systems. The first consisted of phagocyte membranes p47(phox), p67(phox), and Rac1 and an amphiphile; the second was p47(phox)- and amphiphile-free and contained prenylated Rac1. We identified 10 clusters of inhibitory peptides with IC(50) values of 10 μM, all of which were inhibitory, also in the absence of p47(phox). Based on the identification of residues shared by peptides in a particular cluster, we defined 10 functional domains in the Nox2 DH region. One domain corresponded to one FAD-binding subdomain, and four domains overlapped parts of three NADPH-binding subdomains. As expected, most inhibitory peptides acted only when added prior to the completion of oxidase assembly, but peptides associated with two NADPH-binding subdomains were also active after assembly. Kinetic analysis demonstrated that inhibition by peptides was not explained by competition for substrates (FAD, NADPH) but was of a more complex nature: noncompetitive with respect to FAD and uncompetitive with respect to NADPH. We conclude that oxidase-inhibitory peptides, in five out of 10 clusters identified, act by interfering with FAD- and NADPH-related redox reactions.Journal of leukocyte biology 12/2011; 91(3):501-15. DOI:10.1189/jlb.1011507 · 4.29 Impact Factor
Article: Reversing Bacterial Resistance to Antibiotics by Phage-Mediated Delivery of Dominant Sensitive Genes[Show abstract] [Hide abstract]
ABSTRACT: Pathogen resistance to antibiotics is a rapidly growing problem, leading to an urgent need for novel antimicrobial agents. Unfortunately, development of new antibiotics faces numerous obstacles, and a method that resensitizes pathogens to approved antibiotics therefore holds key advantages. We present a proof of principle for a system that restores antibiotic efficiency by reversing pathogen resistance. This system uses temperate phages to introduce, by lysogenization, the genes rpsL and gyrA conferring sensitivity in a dominant fashion to two antibiotics, streptomycin and nalidixic acid, respectively. Unique selective pressure is generated to enrich for bacteria that harbor the phages carrying the sensitizing constructs. This selection pressure is based on a toxic compound, tellurite, and therefore does not forfeit any antibiotic for the sensitization procedure. We further demonstrate a possible way of reducing undesirable recombination events by synthesizing dominant sensitive genes with major barriers to homologous recombination. Such synthesis does not significantly reduce the gene's sensitization ability. Unlike conventional bacteriophage therapy, the system does not rely on the phage's ability to kill pathogens in the infected host, but instead, on its ability to deliver genetic constructs into the bacteria and thus render them sensitive to antibiotics prior to host infection. We believe that transfer of the sensitizing cassette by the constructed phage will significantly enrich for antibiotic-treatable pathogens on hospital surfaces. Broad usage of the proposed system, in contrast to antibiotics and phage therapy, will potentially change the nature of nosocomial infections toward being more susceptible to antibiotics rather than more resistant.Applied and Environmental Microbiology 11/2011; 78(3):744-51. DOI:10.1128/AEM.05741-11 · 3.67 Impact Factor
Article: Tripartite Chimeras Comprising Functional Domains Derived from the Cytosolic NADPH Oxidase Components p47phox, p67phox, and Rac1 Elicit Activator-independent Superoxide Production by Phagocyte Membranes: AN ESSENTIAL ROLE FOR ANIONIC MEMBRANE PHOSPHOLIPIDS[Show abstract] [Hide abstract]
ABSTRACT: The superoxide-generating NADPH oxidase is converted to an active state by the assembly of a membrane-localized cytochrome b(559) with three cytosolic components: p47(phox), p67(phox), and GTPase Rac1 or Rac2. Assembly involves two sets of protein-protein interactions: among cytosolic components and among cytosolic components and cytochrome b(559) within its lipid habitat. We circumvented the need for interactions among cytosolic components by constructing a recombinant tripartite chimera (trimera) consisting of the Phox homology (PX) and Src homology 3 (SH3) domains of p47(phox), the tetratricopeptide repeat and activation domains of p67(phox), and full-length Rac1. Upon addition to phagocyte membrane, the trimera was capable of oxidase activation in vitro in the presence of an anionic amphiphile. The trimera had a higher affinity (lower EC(50)) for and formed a more stable complex (longer half-life) with cytochrome b(559) compared with the combined individual components, full-length or truncated. Supplementation of membrane with anionic but not neutral phospholipids made activation by the trimera amphiphile-independent. Mutagenesis, truncations, and domain replacements revealed that oxidase activation by the trimera was dependent on the following interactions: 1) interaction with anionic membrane phospholipids via the poly-basic stretch at the C terminus of the Rac1 segment; 2) interaction with p22(phox) via Trp(193) in the N-terminal SH3 domain of the p47(phox) segment, supplementing the electrostatic attraction; and 3) an intrachimeric bond among the p67(phox) and Rac1 segments complementary to their physical fusion. The PX domain of the p47(phox) segment and the insert domain of the Rac1 segment made only minor contributions to oxidase assembly.Journal of Biological Chemistry 08/2007; 282(30):22122-39. DOI:10.1074/jbc.M701497200 · 4.57 Impact Factor
Article: Cell-Free Assays[Show abstract] [Hide abstract]
ABSTRACT: The superoxide (O2-)-generating enzyme complex of phagocytes, known as the NADPH oxidase, can be assayed in a number of in vitro cell-free (or broken cell) systems. These consist of a mixture of the individual components of the NADPH oxidase, derived from resting phagocytes or in the form of purified recombinant proteins, exposed to an activating agent (or situation), in the presence of NADPH and oxygen. O2- produced by the mixture is measured by being trapped immediately after its generation with an appropriate acceptor in a kinetic assay, which permits the calculation of the linear rate of O2- production over time. Cell-free assays are distinguished from whole-cell assays or assays performed on membranes derived from stimulated cells by the fact that all components in the reaction are derived from resting, nonstimulated cells and, thus, the steps of NADPH oxidase activation (precatalytic [assembly] and catalytic) occur in vitro. Cell-free assays played a paramount role in the identification of the components of the NADPH oxidase complex, the diagnosis of various forms of chronic granulomatous disease (CGD), and, more recently, the analysis of the domains present on the components of the NADPH oxidase participating in protein-protein interactions leading to the assembly of the active complex.Methods in Molecular Biology 02/2007; 412:385-428. DOI:10.1007/978-1-59745-467-4_25 · 1.29 Impact Factor
Article: No Single Irreplaceable Acidic Residues in the Escherichia coli Secondary Multidrug Transporter MdfA[Show abstract] [Hide abstract]
ABSTRACT: The largest family of solute transporters (major facilitator superfamily [MFS]) includes proton-motive-force-driven secondary transporters. Several characterized MFS transporters utilize essential acidic residues that play a critical role in the energy-coupling mechanism during transport. Surprisingly, we show here that no single acidic residue plays an irreplaceable role in the Escherichia coli secondary multidrug transporter MdfA. Copyright © 2006, American Society for Microbiology. All Rights Reserved.Journal of Bacteriology 09/2006; 188(15):5635-9. DOI:10.1128/JB.00422-06 · 2.81 Impact Factor
Article: Liposomes Comprising Anionic but Not Neutral Phospholipids Cause Dissociation of Rac(1 or 2) ⅐ RhoGDI Complexes and Support Amphiphile-independent NADPH Oxidase Activation by Such Complexes *[Show abstract] [Hide abstract]
ABSTRACT: Activation of the phagocyte NADPH oxidase involves the assembly of a membrane-localized cytochrome b559 with the cytosolic components p47(phox), p67(phox), p40(phox), and the GTPase Rac (1 or 2). In resting phagocytes, Rac is found in the cytosol as a prenylated protein in the GDP-bound form, associated with the Rho GDP dissociation inhibitor (RhoGDI). In the process of NADPH oxidase activation, Rac is dissociated from RhoGDI and translocates to the membrane, in concert with the other cytosolic components. The mechanism responsible for dissociation of Rac from RhoGDI is poorly understood. We generated Rac(1 or 2) x RhoGDI complexes in vitro from recombinant Rac(1 or 2), prenylated enzymatically, and recombinant RhoGDI, and purified these by anion exchange chromatography. Exposing Rac(1 or 2)(GDP) x RhoGDI complexes to liposomes containing four different anionic phospholipids caused the dissociation of Rac(1 or 2)(GDP) from RhoGDI and its binding to the anionic liposomes. Rac2(GDP) x RhoGDI complexes were more resistant to dissociation, reflecting the lesser positive charge of Rac2. Liposomes consisting of neutral phospholipid did not cause dissociation of Rac(1 or 2) x RhoGDI complexes. Rac1 exchanged to the hydrolysis-resistant GTP analogue, GMPPNP, associated with RhoGDI with lower affinity than Rac1(GDP) and Rac1(GMPPNP) x RhoGDI complexes were more readily dissociated by anionic liposomes. Rac1(GMPPNP) x RhoGDI complexes elicited NADPH oxidase activation in native phagocyte membrane liposomes in the presence of p67(phox), without the need for an anionic amphiphile, as activator. Both Rac1(GDP) x RhoGDI and Rac1(GMPPNP) x RhoGDI complexes elicited amphiphile-independent, p67(phox)-dependent NADPH oxidase activation in phagocyte membrane liposomes enriched in anionic phospholipids but not in membrane liposomes enriched in neutral phospholipids.Journal of Biological Chemistry 08/2006; 281(28):19204-19. DOI:10.1074/jbc.M600042200 · 4.57 Impact Factor
Article: Assembly of the phagocyte NADPH oxidase complex: Chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships[Show abstract] [Hide abstract]
ABSTRACT: Phagocytes generate superoxide (O2*-) by an enzyme complex known as reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Its catalytic component, responsible for the NADPH-driven reduction of oxygen to O2*-, is flavocytochrome b559, located in the membrane and consisting of gp91phox and p22phox subunits. NADPH oxidase activation is initiated by the translocation to the membrane of the cytosolic components p47phox, p67phox, and the GTPase Rac. Cytochrome b559 is converted to an active form by the interaction of gp91phox with p67phox, leading to a conformational change in gp91phox and the induction of electron flow. We designed a new family of NADPH oxidase activators, represented by chimeras comprising various segments of p67phox and Rac1. The prototype chimera p67phox (1-212)-Rac1 (1-192) is a potent activator in a cell-free system, also containing membrane p47phox and an anionic amphiphile. Chimeras behave like bona fide GTPases and can be prenylated, and prenylated (p67phox -Rac1) chimeras activate the oxidase in the absence of p47phox and amphiphile. Experiments involving truncations, mutagenesis, and supplementation with Rac1 demonstrated that the presence of intrachimeric bonds between the p67phox and Rac1 moieties is an absolute requirement for the ability to activate the oxidase. The presence or absence of intrachimeric bonds has a major impact on the conformation of the chimeras, as demonstrated by fluorescence resonance energy transfer, small angle X-ray scattering, and gel filtration. Based on this, a "propagated wave" model of NADPH oxidase activation is proposed in which a conformational change initiated in Rac is propagated to p67phox and from p67phox to gp91phox.Journal of Leukocyte Biology 06/2006; 79(5):881-95. DOI:10.1189/jlb.1005553 · 4.29 Impact Factor
Article: 3D Model of the Escherichia coli Multidrug Transporter MdfA Reveals an Essential Membrane-Embedded Positive Charge †[Show abstract] [Hide abstract]
ABSTRACT: MdfA is an Escherichia coli multidrug transporter of the major facilitator superfamily (MFS) of secondary transporters. Although several aspects of multidrug recognition by MdfA have been characterized, better understanding the detailed mechanism of its function requires structural information. Previous studies have modeled the 3D structures of MFS proteins, based on the X-ray structure of LacY and GlpT. However, because of poor sequence homology, between LacY, GlpT, and MdfA additional constraints were required for a reliable homology modeling. Using an algorithm that predicts the angular orientation of each transmembrane helix (TM) (kPROT), we obtained a remarkably similar pattern for the 12 TMs of MdfA and those of GlpT and LacY, suggesting that they all have similar helix packing. Consequently, a 3D model was constructed for MdfA by structural alignment with LacY and GlpT, using the kPROT results as an additional constraint. Further refinement and a preliminary evaluation of the model were achieved by correlated mutation analysis and the available experimental data. Surprisingly, in addition to the previously characterized membrane-embedded glutamate at position 26, the model suggests that Asp34 and Arg112 are located within the membrane, on the same face of the cavity as Glu26. Importantly, Arg112 is evolutionarily conserved in secondary drug transporters, and here we show that a positive charge at this position is absolutely essential for multidrug transport by MdfA.Biochemistry 12/2005; 44(45):14870-80. DOI:10.1021/bi051574p · 3.02 Impact Factor
Article: Activation of the phagocyte NADPH oxidase by Rac guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. Vol. 280 (2005) 3802-3811Journal of Biological Chemistry 03/2005; 280(12):12064-12064. · 4.57 Impact Factor
Article: Activation of the Phagocyte NADPH Oxidase by Rac Guanine Nucleotide Exchange Factors in Conjunction with ATP and Nucleoside Diphosphate Kinase[Show abstract] [Hide abstract]
ABSTRACT: Activation of the phagocyte NADPH oxidase is the consequence of the assembly of membranal cytochrome b559 with the cytosolic components p47phox, p67phox, and the GTPase Rac and is mimicked by a cell-free system comprising these components and an activator. We designed a variant of this system, consisting of membranes, p67phox) prenylated Rac1-GDP, and the Rac-specific guanine nucleotide exchange factor (GEF) Trio, in which oxidase activation is induced in the absence of an activator and p47phox. We now show that: 1) Trio and another Rac GEF (Tiam1) act by inducing GDP to GTP exchange on prenylated Rac1-GDP and that our earlier assertion that activation is GTP-independent is explained by contamination of p67phox preparations with GTP and/or ATP. 2) Oxidase activation by Rac GEFs is supported not only by GTP but also by ATP. 3) Non-hydrolysable GTP analogs are active, whereas ATP analogs, incapable of gamma-phosphoryl transfer, are inactive. 4) The ability of ATP to support GEF-induced oxidase activation is explained by ATP serving as a gamma-phosphoryl donor for a membrane-localized nucleoside diphosphate kinase (NDPK), converting GDP to GTP. 5) The existence of a NDPK in macrophage membranes is proven by functional, enzymatic, and immunologic criteria. 6) NDPK acts on free GDP, and the newly formed GTP is bound again to Rac. 7) Free GDP is derived exclusively by dissociation from prenylated Rac1-GDP, mediated by GEF. NDPK and GEF appear to be functionally linked in the sense that the availability of GDP, serving as substrate for NDPK, is dependent on the level of activity of GEF.Journal of Biological Chemistry 03/2005; 280(5):3802-11. DOI:10.1074/jbc.M410257200 · 4.57 Impact Factor
Article: Dual role of rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox[Show abstract] [Hide abstract]
ABSTRACT: NADPH oxidase activation involves the assembly of membrane-localized cytochrome b559 with the cytosolic components p47phox, p67phox, and the small GTPase Rac. Assembly is mimicked by a cell-free system consisting of membranes and cytosolic components, activated by an anionic amphiphile. We reported that a chimeric construct, consisting of residues 1-212 of p67phox and full-length Rac1, activates the oxidase in vitro in an amphiphile-dependent manner, and when prenylated, in the absence of amphiphile and p47phox. We subjected chimera p67phox-(1-212)-Rac1 to mutational analysis and found that: 1) replacement of a single basic residue at the C terminus of the Rac1 moiety by glutamine is sufficient for loss of activity by the non-prenylated chimera; replacement of all six basic residues by glutamines is required for loss of activity by the prenylated chimera. 2) A V204A mutation in the activation domain of the p67phox moiety leads to a reduction in activity. 3) Mutating residues, known to participate in the interaction between free p67phox and Rac1, in the p67phox-(R102E) or Rac1 (A27K, G30S) moieties of the chimera, leads to a marked decrease in activity, indicating a requirement for intrachimeric bonds, in addition to the engineered fusion. 4) Chimeras, inactive because of mutations A27K or G30S in the Rac1 moiety, are reactivated by supplementation with exogenous Rac1-GTP but not with exogenous p67phox. This demonstrates that Rac has a dual role in the assembly of NADPH oxidase. One is to tether p67phox to the membrane; the other is to induce an "activating" conformational change in p67phox.Journal of Biological Chemistry 05/2004; 279(16):16007-16. DOI:10.1074/jbc.M312394200 · 4.57 Impact Factor
Article: Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras.
Top Journals
Tel Aviv University
Tell Afif, Tel Aviv, Israel
- Department of Clinical Microbiology and Immunology
Weizmann Institute of Science
Rechovot, Central District, Israel
- Department of Biological Chemistry


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From Alan Turing to Steve Jobs, these are 43 of the top innovators who brought the world of computing into the high-tech age of tech we take for granted today.
October 01, 2015
Why Big Tech Companies Want to Give Everyone the Internet
Many major tech companies in the U.S. have been talking about how to spread Internet access around the world. Here's why that's such a hot topic right now.
September 19, 2015
Facebook's Dislike Button: What Shape Will It Really Take?
Facebook chief executive Mark Zuckerberg announced that the social network is planning to test a dislike button. What form is the button most likely to take?
September 18, 2015
6 of the Best Virtual Reality Apps Available Right Now
Think virtual reality is the wave of the future? You can see what it's like right now.
September 13, 2015
How to Stop Videos From Auto-Playing on Social Media
Tired of videos playing automatically on social media? Follow these steps to stop it completely on Facebook and Twitter, and on cellular data when on Instagram.
September 07, 2015
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Join our Facebook community to stay up-to-date on our latest articles.
September 06, 2015
5 Apps That Just Keep Getting Worse
Shouldn't a new release of an app mean it's better? With these five apps, somebody didn't get that message.
September 05, 2015
What the Selfie Can Teach You and Your Kids
How has our modern-day use of the selfie really affected us?
August 31, 2015
Facebook's Personal Assistant: What's Different About M?
Facebook is beginning to test M, a new digital personal assistant that lives in Messenger. Here's everything you want know about what makes M different.
August 29, 2015
5 Billion-Dollar Businesses That Began in a Dorm Room
Google, Facebook, and Yahoo! were all founded by students and went on to transform tech. We look at those and others, exploring its contributions.
August 22, 2015
5 Mistakes That Too Many Men Make After a Bad Breakup
Lessen the blow of your breakup by avoiding these common mistakes.
August 11, 2015
7 Social Media Mistakes That Can Get You Fired From Your Job
Sometimes, a social media faux pas is more than embarrassing.
August 05, 2015
4 Negative Effects of Using Facebook Too Much
In recent studies, researchers have revealed the ways in which logging in to Facebook too frequently can hurt you.
August 01, 2015
Are Instagram's Filters Going Out of Style?
A new version of Instagram's Android app seems to indicate that Instagram knows its filters are becoming less relevant.
July 24, 2015
Why Browsing the Internet on Your Phone Is So Terrible
Trying to browse the web on even a high-end smartphone is often a terrible experience. Here's why it's not getting fixed.
July 21, 2015
Another Reason Why the Apple Watch Is Not Very Useful
The Apple Watch isn't yet a useful device for most users. A look at which of the top iPhone apps are available on the Apple Watch reveals one reason why.
July 14, 2015
7 Things That Are Wrong With Your Social Media Profiles
Are you guilty of these seven common mistakes that social network users make on their profiles?
June 27, 2015
3 Things Everyone Should Know Before Starting a Business
Oregon, Utah, Colorado, Missouri, Illinois, Georgia, Delaware, and Massachusetts -- these are the states responsible for the creation of the most new businesses in 2014.
June 24, 2015
Why Taking Social Media Breaks Destroys Your Work Day
You might think you've earned a few minutes on Facebook after completing a task at work. But taking frequent social media breaks can derail your productivity.
June 15, 2015
Want to Network Successfully? Get Off LinkedIn (For Starters)
Networking is a vital but sometimes overwhelming necessity of workplace culture. Here's how to succeed at it.
June 11, 2015
Why There Are So Many Ads on Social Networks
Ads are starting to show up all over your favorite social networks. Here's why social media ads and commerce are a big trend -- and are here are to stay.
June 07, 2015
Forget FOX News, Facebook May Be What's Truly Dividing America
We often blame the news media for creating political and social echo chambers, but what we should really be blaming is social media.
June 03, 2015
How to Improve Your Facebook Security (With This New Tool)
Facebook is rolling out a new feature that enables you to better protect your privacy on the social network.
May 30, 2015
See How Much Money Your Social Networks Make Off of You
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May 24, 2015
How to Delete Your Facebook Account
Whether you have an unhealthy addiction to Facebook or you never use it, you have to know when to bail. Here's how to quit the social network.
May 21, 2015
How to Use Facebook Messenger and Its 5 Core Features
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May 20, 2015
What Mobile Apps Do We Use the Most?
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Richmond, TXUSA
Hometown: Richmond
November 23, 2012
Advanced Amateur.
Yes, I have Photoshop CS6 Extended.
Hey, photography is a passion of mine and look forward to every opportunity to practice my craft!
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Hoping to reprise the successful uprising staged last year against online piracy legislation, privacy advocacy groups have vowed to mark the passing of Internet activist Aaron Swartz with an online protest in February against the National Security Agency's electronic surveillance practices.
On Feb. 11, Access, Demand Progress, the Electronic Frontier Foundation, Free Press, Boing Boing, Reddit, Mozilla and other groups are asking Internet users to post banners on their own websites, call and email lawmakers, develop Internet memes, and change their social media avatars to protest NSA's broad collection of metadata as part of The Day We Fight Back campaign.
Swartz, who helped create the RSS Web feed format and Reddit social news site, was a fierce activist for open access and electronic privacy. He was arrested by Massachusetts Institute of Technology police in 2011 and charged with downloading a large number of academic journal articles through the university's computer network. He committed suicide on Jan. 11, 2013 -- two days after prosecutors denied his lawyer's second offer of a plea bargain.
At the time of his death, Swartz was facing charges of wire fraud, computer fraud, computer damage and other felonies that carried a potential sentence of 50 years in federal prison and $1 million in fines. The penalties prompted accusations from Swartz supporters of prosecutorial bullying and excess.
Swartz was a key figure in the 2012 defeat of the Stop Online Piracy Act (SOPA). Opponents contended that the bill, which sought to protect copyrighted materials online, would have blocked access to legal websites and destroyed the interconnectedness on which the Internet depends. They used many of the techniques in fighting the bill that organizers of the Feb. 11 event are calling for.
Swartz co-founded Demand Progress in 2012 with David Segal, the organization's current executive director, to stop SOPA.
Internet piracy bills stall as public outcry builds
Anonymous hacks FTC website OnGuardOnline.gov
The battle against SOPA also had a darker side as sympathetic hacktivist groups used denial-of-service attacks to block access to the websites of companies and organizations that supported the legislation, such as the Recording Industry Association of America and CBS.com. Some groups have also used hacks to commemorate Swartz. Last January, two MIT websites were hacked and pasted with tributes to Swartz. At about the same time, the university's email system was taken down by hackers. Later that month, the U.S. Sentencing Commission's website was also breached.
Meanwhile, lawmakers are looking for more information about how Swartz's legal case was handled. Eight members of Congress sent a letter to the Justice Department on Jan. 10 seeking additional details on the inquiry.
"We regret that the information your department has provided to date has not been satisfactory -- among other things, it painted a picture of prosecutors unwilling or unable to weigh what charges to pursue against a defendant," the letter states. It was signed by four Democrats and four Republicans, and was a follow-up to a letter sent by Sens. John Cornyn (R–Texas) and Al Franken (D–Minn.) a year ago.
The latest letter also charges that there were inconsistencies between the Justice Department's report and MIT's report.
About the Authors
Reid Davenport is an FCW editorial fellow. Connect with him on Twitter: @ReidDavenport.
Mark Rockwell is a staff writer covering acquisition, procurement and homeland security. Contact him at email@example.com or follow him on Twitter at @MRockwell4.
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The General Services Administration's Enterprise Infrastructure Solutions contract will anchor the agency's NS 2020 telecommunications strategy.
House and Senate both approve a measure to maintain funding at fiscal 2015 levels through Dec. 11.
The aviation regulator missed a Congressional deadline to develop rules of the sky-ways for drones.
Agency heads, acquisition officers and even CIOs don't need to be hard-core techies. FCW's four-part look at the expertise that's really required to make federal IT run.
FCW recognizes 14 individuals having an outsized impact early in their careers.
As Steve Kelman returns from a summer of aggressive medical treatment, he considers the all-too-common aversion to short-term sacrifices.
Massive open online courses can offer specialized IT instruction on a flexible schedule and on the cheap. That may not always mesh with government's preference for structure and certification, however.
The federal government craves more cybersecurity professionals. These six schools are helping meet that demand.
Former ACT president will take a job with Gartner, follow his spouse to Vienna, Austria.
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Goodbye to All That: Dispelling America's Memorial Myths
Arthur Silber offers most appropriate observations for the solemn Memorial Day weekend: Against Annihilation of the Spirit: Let Us All Become Cowards.
The piece also makes reference to Paul Fussell, one of the clearest-eyed observers of the reality of war ever produced on American shores. Fussell died this week: a good strong light gone out.
No excerpts this time: just get over there and read Silber's piece.
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Attorneys fight another round over Susan Powell trust money
Elaine Thompson, Associated Press
SALT LAKE CITY — Saying that there is no reason not to believe he will fulfill his duties as conservator of his daughter's estate appropriately, attorneys for Chuck Cox have fired back at Alina and Terrica Powell.
Last week, a U.S. District judge issued an order about who should get the money from three separate life insurance policies tied to Josh Powell and his missing wife, Susan Cox Powell. But a trust established by Josh and Susan Powell remains in dispute in Utah.
Currently, Cox is the sole benefactor of the trust and would receive 100 percent of the money, or about $2.3 million. Terrica Powell, Josh Powell's mother, would still receive more than $756,000 from the other policies.
But Terrica Powell and Alina Powell, Josh Powell's sister, contend they were illegally removed from the trust and are challenging the issue in court. At the very least, they want the court to require Cox to obtain court approval for any expenditures or distribution of conservatorship assets.
In new court papers filed Wednesday, Cox's attorney argues that the conservatorship and trust are good the way they currently are, and that his client has not embezzled and will not misappropriate funds.
"The Powells had no factual basis for their motion so they founded it instead upon insult. The conservator has shown completely appropriate regard for all of his responsibilities in acting in the best interest of the estate. He has suffered immense loss and does not deserve such unfounded invective. There is no basis to assert he will do anything other than perform his duties appropriately in the future," Cox's attorneys wrote.
"The Powells' motion is baseless and serves no other purpose than to harass and waste time and resources. It should be denied."
Susan Powell went missing from her West Valley home in late 2009. Investigators believe her husband killed her. Josh Powell murdered their two young sons and killed himself in 2012.
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We're looking at a long, nearly straight, almost totally traffic-free downhill. We'd climbed up to the base of the Palm Springs to Idyllwild Ariel Tramway. Our goal was to see how fast Mitsubishi's tiny i could go. We're on the gas, and the teensy, turbocharged 660cc three-banger is giving us all its got. The speedometer ticks upwards, now cresting 100. In front of us is nothing but inviting tarmac. Deeper and harder we push and the numbers keep ticking up. 119, 120, 121 and then finally hitting 122. We felt we left a little on the table and could have probably achieved a terminal velocity of around 130. Maybe. 125 for sure.
Before you crime and punishment types climb upon your soapboxes, we should mention that the right-hand drive, JDM-only i reads out in kilometers per hour. Meaning that our top speed was almost 76 mph. And we stand by our assertion that we totally could have hit 80 mph.


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ANN ARBOR, Mich. — In response to a need for a more efficient mode of transit between the University of Michigan-Ann Arbor's North and Central Campuses, Ann Arbor Transit Authority is working with the University and city officials on two projects to enhance local and county transit, The Michigan Daily reports.
The first project, the Ann Arbor Connector Feasibility Study, will identify advanced transit options that would be installed in the city, such as trains or larger buses. The second project is the agency's countywide transit master plan, which is aimed at improving and expanding the city's busing system. For the full story, click here.
The agency is already providing enhanced routes and options through a unique 5-year partnership agreement with Megabus.com which began last year, to offer express travel to and from Miami and Orlando for as little as $1.
The 20th installment of the show featured more than 50 new exhibitors, 70-plus vehicles and plenty of information to inspire attendees.
A bipartisan measure has been introduced in the lower chamber that would push back the deadline for most railroads to install automated train technology until December 2018.
The new Plattsburgh, N.Y., building will be equipped of a welcoming customer area, 10 bus delivery spaces and offices to enable our customers to continue their professional activities during their stay.
Fleet managers for transit agencies, universities and schools, governments and for-hire transit companies are encouraged to register while spaces are still available.
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PCSO Investigating Child Drowning Case
Posted: 12/24/2012 12:00 AM
On Thursday, December 20, 2012 at 1:34 p.m. the Pinal County Sheriff's Office received a 9-1-1 call from
William Miller (
age 26, San Tan Valley
) indicating his 4 month old baby had possibly drowned. Deputies
responded to the 4800 block of East Whitehall Drive, San Tan Valley.
The first deputy arrived on the scene within a few minutes and relieved William from doing CPR on the child.
The deputy and a sergeant who was on scene continued providing the child CPR until medics arrived. The
child was provided additional medical treatment and then transported by air ambulance to Cardon Children's
Hospital in Mesa where she was later pronounced deceased.
William told deputies he had put his 1 ½ year old child down for a nap. He was then giving his 4 month old
daughter Georgia a bath. Georgia was put into a child bath seat inside of the tub. A few inches of water was
put into the tub. While giving Georgia the bath, the 1 ½ year got out of bed and came into the bathroom.
William left Georgia alone for approximately 90 seconds and put the 1 ½ back into bed. When William
returned, he found Georgia was face down in the water.
Sheriff Paul Babeu stated, "
We can only imagine how incredibly painful it must be to lose a child and it's
magnified around Christmas. Too often we hear about parents leaving children alone for only a short time
around water. What parents need to understand is that anytime a child is left alone around water is too
Public Information Officer
Mark Clark
Other Stories
PCSO Announces 9 Promotions of Sworn and Detention Staff
The Pinal County Sheriff's Office is proud to announce the recent promotions of four sergeants, two lieutenants, two captains and one deputy chief. Of the promoted, four are from detention and five are from enforcement. The promoted employees will
DOC Prisoner Seriously Injured in Assault
On September 20, at 6:45 p.m., a 37-year-old male Department of Corrections inmate, being temporarily housed at the PCSO Adult Detention Center, was assaulted by a fellow DOC inmate in the E-Unit recreation area. The assault victim was transported to a
Pinal Deputies Bust Counterfeit Ring in San Tan Valley
On the morning of September 2, Pinal County deputies served a search warrant on a residence at 2183 W. Tanner Ranch Road, in San Tan Valley, to further an investigation into counterfeiting of U.S currency. Upon searching the home, deputies discovered e
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Tollgate Farm, Bishops Tachbrook
- Name:
- Tollgate Farm
- Address:
- Banbury Road
- Postcode/City:
- CV33 9QJ Bishops Tachbrook
- County:
- Warwickshire
- Phone:
- 01926 65179001926 651790
- Fax:
- 01926 651583
Updated more than 6 months ago | Claim This Business| Report Incorrect Data
Keywords:Poultry, Poultry Products, Poultry Industry, Poultry Farmers, Poultry Farming, Game and Poultry, Poultry Supplies
The company Tollgate Farm is listed in the following categories:
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CV37 0LP Stratford-Upon-Avon
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Details Press ShopPheasant Oak Farm, Hob Lane, Balsall Common
CV7 7GX Balsall Common
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Overall Rating:
these help to make the job ver neat, but I am hoping that they don't become brittle and crack because to replace them later would mean removing all the boards.
Great product allowing decking to be fixes without screw holes.
However one must be careful not to screw the fixing too tightly into sub frame, as the plastic breaks.
AB Fixings Clips for the Installation of AB Composite Decking
(as a rough guide you will need 5.5 fixings per 2.2m deck board)
Works as a Fixing and as a Spacer.


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Challenge level:
How many different ways can you find of fitting five hexagons
together? How will you know you have found all the ways?
Take a rectangle of paper and fold it in half, and half again, to
make four smaller rectangles. How many different ways can you fold
it up?
Hover your mouse over the counters to see which ones will be
removed. Click to remover them. The winner is the last one to
remove a counter. How you can make sure you win?
A tetromino is made up of four squares joined edge to edge. Can
this tetromino, together with 15 copies of itself, be used to cover
an eight by eight chessboard?
Cut four triangles from a square as shown in the picture. How many
different shapes can you make by fitting the four triangles back
What is the best way to shunt these carriages so that each train
can continue its journey?
10 space travellers are waiting to board their spaceships. There
are two rows of seats in the waiting room. Using the rules, where
are they all sitting? Can you find all the possible ways?
A challenging activity focusing on finding all possible ways of stacking rods.
You have 4 red and 5 blue counters. How many ways can they be
placed on a 3 by 3 grid so that all the rows columns and diagonals
have an even number of red counters?
Can you shunt the trucks so that the Cattle truck and the Sheep
truck change places and the Engine is back on the main line?
Design an arrangement of display boards in the school hall which fits the requirements of different people.
How many DIFFERENT quadrilaterals can be made by joining the dots
on the 8-point circle?
What is the smallest cuboid that you can put in this box so that
you cannot fit another that's the same into it?
Take 5 cubes of one colour and 2 of another colour. How many
different ways can you join them if the 5 must touch the table and
the 2 must not touch the table?
What is the greatest number of counters you can place on the grid below without four of them lying at the corners of a square?
Swap the stars with the moons, using only knights' moves (as on a
chess board). What is the smallest number of moves possible?
Use the interactivity to listen to the bells ringing a pattern. Now
it's your turn! Play one of the bells yourself. How do you know
when it is your turn to ring?
Arrange 9 red cubes, 9 blue cubes and 9 yellow cubes into a large 3 by 3 cube. No row or column of cubes must contain two cubes of the same colour.
Can you put the numbers 1 to 8 into the circles so that the four
calculations are correct?
Can you put the numbers from 1 to 15 on the circles so that no
consecutive numbers lie anywhere along a continuous straight line?
A magician took a suit of thirteen cards and held them in his hand
face down. Every card he revealed had the same value as the one he
had just finished spelling. How did this work?
Make your own double-sided magic square. But can you complete both
sides once you've made the pieces?
Place the numbers 1 to 10 in the circles so that each number is the
difference between the two numbers just below it.
Building up a simple Celtic knot. Try the interactivity or download
the cards or have a go on squared paper.
How many different symmetrical shapes can you make by shading triangles or squares?
These practical challenges are all about making a 'tray' and covering it with paper.
In how many ways can you stack these rods, following the rules?
Can you find all the different ways of lining up these Cuisenaire
In how many ways can you fit two of these yellow triangles
together? Can you predict the number of ways two blue triangles can
be fitted together?
An activity making various patterns with 2 x 1 rectangular tiles.
How can you arrange the 5 cubes so that you need the smallest number of Brush Loads of paint to cover them? Try with other numbers of cubes as well.
A dog is looking for a good place to bury his bone. Can you work
out where he started and ended in each case? What possible routes
could he have taken?
Is it possible to place 2 counters on the 3 by 3 grid so that there
is an even number of counters in every row and every column? How
about if you have 3 counters or 4 counters or....?
How many different triangles can you make on a circular pegboard that has nine pegs?
Using different numbers of sticks, how many different triangles are
you able to make? Can you make any rules about the numbers of
sticks that make the most triangles?
Investigate the smallest number of moves it takes to turn these
mats upside-down if you can only turn exactly three at a time.
Use the interactivity to play two of the bells in a pattern. How do
you know when it is your turn to ring, and how do you know which
bell to ring?
Place the numbers 1 to 8 in the circles so that no consecutive
numbers are joined by a line.
Investigate the different ways you could split up these rooms so
that you have double the number.
Place eight queens on an chessboard (an 8 by 8 grid) so that none
can capture any of the others.
How many shapes can you build from three red and two green cubes? Can you use what you've found out to predict the number for four red and two green?
Can you recreate these designs? What are the basic units? What
movement is required between each unit? Some elegant use of
procedures will help - variables not essential.
An extra constraint means this Sudoku requires you to think in
diagonals as well as horizontal and vertical lines and boxes of
Four numbers on an intersection that need to be placed in the
surrounding cells. That is all you need to know to solve this
The letters of the word ABACUS have been arranged in the shape of a
triangle. How many different ways can you find to read the word
ABACUS from this triangular pattern?
There is a long tradition of creating mazes throughout history and across the world. This article gives details of mazes you can visit and those that you can tackle on paper.
Find out what a "fault-free" rectangle is and try to make some of
your own.
Here you see the front and back views of a dodecahedron. Each
vertex has been numbered so that the numbers around each pentagonal
face add up to 65. Can you find all the missing numbers?
You cannot choose a selection of ice cream flavours that includes
totally what someone has already chosen. Have a go and find all the
different ways in which seven children can have ice cream.
Bellringers have a special way to write down the patterns they
ring. Learn about these patterns and draw some of your own.