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Royalty Free Music Unique To Your Project - Every Time
Royalty Free Music — Unique To Your Project – Every Time
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The following tracks match: Hypnotic, Melancholy, Piano
Equilibriumhttps://www.smartsound.com/artist/images/ASFB03_200.jpgSingle7100027-ST$ 39.957100027-EX$ 69.957100027-W$ 149.95Keywords: Mysterious, Positive, Inspirational, Atmospheric, Delicate, Dramatic, Ethereal, Gentle, Haunting, Heartwarming, Hypnotic, Incessant, Inspiring, Majestic, Melancholy, Mystical, Panoramic, Sad, Serene, Somber, Tender, Touching, Ambient, Mellow, Emotional, Magical, Dark, Tormented Instrument: Orchestra, Studio Orchestra, Flute, Oboe, Piano, Strings, Violin, Violoncello, Acoustic, Instrumental Genre: Elegant, Nostalgic, Orchestral Production Types: Cinematic, Commercials, Indie Film, Film Trailer, Horror, Action-Drama, Tribute/Memorial
Equilibrium from the album Magical Moments
Raindrop Dancehttps://www.smartsound.com/artist/images/ASFB03_200.jpgSingle7100029-ST$ 39.957100029-EX$ 69.957100029-W$ 149.95Keywords: Exciting, Positive, Inspirational, Bold, Delicate, Dramatic, Effervescent, Ethereal, Fresh, Gentle, Heartwarming, Hypnotic, Incessant, Innocent, Inspiring, Mechanical, Melancholy, Motivating, Passionate, Pensive, Powerful, Refreshing, Serene, Touching, Hopeful, Emotional, Fantasy, Magical Instrument: Orchestra, Studio Orchestra, Celeste, Flute, Guitar (Acoustic), Guitar (Electric), Piano, Strings, Violin, Violoncello, Acoustic, Instrumental, Guitar Genre: Elegant, Orchestral Production Types: Cinematic, Commercials, Documentary, Nature, Film Trailer
Raindrop Dance from the album Magical Moments
Promises To KeepThis pacing dramatic work is good for those slighty tense moments in your storyline. Steady piano phrases keep the motion going.https://www.smartsound.com/strata/images/STRATTR_200.jpgSingle62008-ST$ 39.9562008-EX$ 69.9562008-W$ 149.95Keywords: Mysterious, Haunting, Hypnotic, Melancholy, Subdued, Drama, Investigative, Quiet, Soft Instrument: Piano, Instrumental Genre: Themes, Indie, Orchestral Production Types: TV/ Film Drama, Documentary, Indie Film, Short Film, Action-Drama, Biography, Spoken Word/Narration, Background
Promises To Keep from the album Time Remembered
The following tracks match: Hypnotic, Piano
Empty SurpriseWarm and reflective with light percussion and bass offer a sentimental and introspective mood.https://www.smartsound.com/strata/images/STRATUBU_200.jpgSingle7100210-ST$ 39.957100210-EX$ 69.957100210-W$ 149.95Instrument: Bass (Acoustic), Drums, Piano, Piano (Electric), Synthesizer, Instrumental Keywords: Mysterious, Atmospheric, Calm, Gentle, Hypnotic, Intimate, Pensive, Reflective, Relaxed, Ambient, Mellow, Investigative, Magical, Quiet, Soft Genre: Nostalgic, Various Production Types: Commercials, Documentary, Background
Empty Surprise from the album Upright Bass Underscores
Burning HotSyncopated effects open this lively, cheerful and energetic tune that roars and pops with animation as it explodes into a bouncy, dynamic tempo.https://www.smartsound.com/strata/images/STRATUP_200.jpgSingle7100104-ST$ 39.957100104-EX$ 69.957100104-W$ 149.95Instrument: Electronic, Bass (Electric), Chimes, Drums, Guitar (Acoustic), Guitar (Electric), Piano, Strings, Synthesizer, Guitar Keywords: Driving, Energetic, Exciting, Positive, Uplifting, Inspirational, Atmospheric, Bold, Competitive, Confident, Fierce, Hypnotic, Incessant, Inspiring, Motivating, Powerful, Pulsating, Punchy, Refreshing, Striving, Triumphant, Ambient, Hopeful, Upbeat Genre: Corporate/Technology, Rockin, Dance, Electronica, Pop Rock, House Production Types: Sports, Commercials, Corporate, Corporate Communications, Intros/Bumpers/Stingers, Product Videos, Background
Burning Hot from the album Updraft
Moment Of TruthBooming instrumentals announce this taut, tense and suspenseful track with its haunting but hopeful score as it soars heavenward with stirring orchestral effects.https://www.smartsound.com/strata/images/STRATUP_200.jpgSingle7100114-ST$ 39.957100114-EX$ 69.957100114-W$ 149.95Instrument: Electronic, Bass (Electric), Drums, Guitar (Electric), Harp, Piano, Strings, Synthesizer, Choir, Guitar Keywords: Exciting, Positive, Uplifting, Inspirational, Atmospheric, Calm, Delicate, Heartwarming, Hypnotic, Inspiring, Pensive, Pulsating, Relaxed, Touching, Tranquil, Emotional, Quiet, Soft Genre: Corporate/Technology, Alternative Rock, Electronica, Pop Rock Production Types: Commercials, Corporate, Nature, Corporate Communications, Product Videos, Background
Moment Of Truth from the album Updraft
We Believe In ScienceAcoustic piano, bells and chimes bring life to this cheerful melody as hand drums and percussion lead this track forward with an imaginative and outdoorsy ring.https://www.smartsound.com/strata/images/STRATUP_200.jpgSingle7100098-ST$ 39.957100098-EX$ 69.957100098-W$ 149.95Instrument: Electronic, Bass (Electric), Drums, Percussion, Piano, Synthesizer Keywords: Driving, Energetic, Exciting, Positive, Uplifting, Inspirational, Atmospheric, Competitive, Confident, Dignified, Effervescent, Fresh, Hypnotic, Incessant, Inspiring, Mechanical, Motivating, Powerful, Pulsating, Refreshing, Triumphant, Hopeful, Angelic, Upbeat Genre: Corporate/Technology, Alternative Rock, Pop Rock Production Types: Commercials, Corporate, Corporate Communications, Home Videos, Product Videos, Science, Training, Background
We Believe In Science from the album Updraft
A Hazy FutureElectronica piano and chimes create an ethereal feeling with complex textures and a melody that spirals hauntingly through the tune.https://www.smartsound.com/artist/images/ASMR02_200.jpgSingle7100148-ST$ 39.957100148-EX$ 69.957100148-W$ 149.95Instrument: Ethnic Ensemble, Bass (Acoustic), Guitar (Electric), Percussion, Piano, Piano (Electric), Synthesizer, Instrumental, Guitar Keywords: Positive, Uplifting, Inspirational, Atmospheric, Delicate, Ethereal, Heartwarming, Hypnotic, Incessant, Inspiring, Motivating, Mystical, Pensive, Tender, Touching, Tranquil, Ambient, Hopeful, Poignant, Quiet Genre: Earthy, Elegant, Indie Artist, New Age, New Age/Easy Production Types: TV/ Film Drama, Commercials, Corporate, Documentary, Film Trailer, Biography, Home Videos, Meditation
A Hazy Future from the album Captivating Portraits
Mantra In BlueDramatic, foreboding strings and cymbal-rolls open this ethereal, romantic and sensual track as it builds to a warm, carefree shuffle.https://www.smartsound.com/artist/images/ASMR02_200.jpgSingle7100149-ST$ 39.957100149-EX$ 69.957100149-W$ 149.95Instrument: Orchestra, Studio Orchestra, Flute, Harp, Percussion, Piano, Strings, Instrumental Keywords: Mysterious, Atmospheric, Brooding, Desolate, Dissonant, Dramatic, Ethereal, Haunting, Hypnotic, Incessant, Mystical, Sad, Scary, Serious, Sinister, Somber, Suspenseful, Tense, Uncertain, Ambient, Emotional, Dark, Tormented Genre: Orchestral, Indie Artist Production Types: TV/ Film Drama, Cinematic, Documentary, Indie Film, Film Trailer, Action-Drama, Biography, Background
Mantra In Blue from the album Captivating Portraits
Strength In TearsRolling, roaring, waterfall-like emotions spill forth from electric guitars, crashing cymbals and gentle keys revealing tender passions.https://www.smartsound.com/artist/images/ASMR02_200.jpgSingle7100144-ST$ 39.957100144-EX$ 69.957100144-W$ 149.95Instrument: Ethnic Ensemble, Ethnic Flute, Guitar (Electric), Percussion, Piano, Synthesizer, Instrumental, Guitar Keywords: Inspirational, Atmospheric, Calm, Ethereal, Heartwarming, Hypnotic, Incessant, Inspiring, Majestic, Motivating, Mystical, Panoramic, Passionate, Powerful, Pulsating, Reflective, Serene, Serious, Solemn, Soothing, Touching, Tranquil, Ambient, Hopeful, Abstract, Emotional, Poignant Genre: Earthy, Processional, World, Exotic, Indie Artist, New Age, Electronica, African, Indie Production Types: TV/ Film Drama, Cinematic, Commercials, Documentary, Indie Film, Nature, Short Film, Film Trailer, Biography, Tribute/Memorial, Background
Strength In Tears from the album Captivating Portraits
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Specialty Retail
Company Overview of Valentino Fashion Group S.p.A.
Company Overview
Valentino Fashion Group S.p.A. operates online boutiques and showrooms that sell fashion and luxury products in Italy and internationally. Its boutiques offer apparel, bags, shoes, and accessories for men and women. The company was founded in 2005 and is based in Milan, Italy. It has stores in Europe, Asia, the Middle East, North America, and South America.
Via Turati 16/18
Milan, MI 20121
Founded in 2005
39 02 624921
39 02 62 49 25 84
Key Executives for Valentino Fashion Group S.p.A.
Valentino Fashion Group S.p.A. Key Developments
Swire Properties Inc. and Simon Property Group announced two additional luxury retailers, iconic Italian fashion house Valentino and bespoke Swiss watch and jewelry designer Chopard, set to open in Brickell City Centre's 500,000 square-foot shopping center in fall 2016. Next week, Brickell City Centre will reveal an additional mix of contemporary brands, which will include a major NYC-based contemporary women's apparel retailer, an American designer of men and women's footwear, an international yoga and fitness apparel chain, a Colombian swimwear brand, among others. The project currently has about 450,000 of its 500,000 square feet in advance negotiations. Both stores will be located in the street-accessible first floor of the outdoor shopping center, which will house Brickell City Centre's luxury retailers. Premium and contemporary retailers will be the emphasis on the second and third floors, along with a mix of beauty, home decor, jewelry, apparel and other retailers. The food and beverage offerings, which are an integral piece of the entire Brickell City Centre retail concept, will offer a mix of fine dining, casual fare and new international brands opening flagships in the U.S.
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Sponsored Financial Commentaries
Sponsored Links
To contact Valentino Fashion Group S.p.A., please visit www.valentinofashiongroup.com. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at firstname.lastname@example.com.

subset: commoncrawl


text:
Liz Stauber
Tom Hiddleston Reveals Why He Was Cut From Avengers: Age Of Ultron
'Avengers: Age of Ultron' would've been just as successful with or without the inclusion of the hugely likeable Tom Hiddleston (we think), but now the actor's revealed why he was cut from the movie. Speaking to Digital Spy, the charming Brit who plays the devilish Loki in the Marvel Cinematic…Mike P Williams
- XFINITYSponsored
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Ellen Page Set To Star In Remake of Flatliners
There have been murmurs for some time that a remake of 'Flatliners,' director Joel Schumacher's 1990 supernatural thriller, was in the works at Sony. Now, Variety report that Ellen Page is in talks to take a leading role in the film. The original 'Flatliners' boasted a high profile 'Brat Pack' cast…Ben Bussey
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When is someone going to open a window in Aaron Sorkin's "Steve Jobs"? Alas, wrong operating system. Sorkin has dispensed with the traditional format of the biopic, instead framing the life of ...Associated Press
China Box Office: Local Titles Dominate Holiday Weekend
Local films dominated the Chinese box office over the holiday weekend, accounting for over 90% of the week's total.Variety
Family of late actor Robin Williams reach settlement in legal dispute
By Piya Sinha-Roy LOS ANGELES (Reuters) - The widow and children of late Oscar-winning actor Robin Williams, who died by suicide last year, have reached a proposed settlement after a bitter dispute over his estate, according to court papers. The settlement, filed in San Francisco Superior Court on…Reuters
- Digital LifeSponsored
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Fox Developing Couples Dancing Show As 'So You Think You Can Dance' Awaits Renewal Decision
Fox has put in development a couples dancing competition show from former The Voice executive producer Stijn Bakkers and American Idol producer FremantleMedia North America. Created/executive produced by Bakkers and Toby Gorman, EVP Alternative at FMNA, the untitled show highlights the lives of…Deadline
'Furious 8' Director Shortlist Down To Last Few
The search for the director of Furious 8 is down to the last few. No deals have been made. No offers have been made. No decisions have been made. Here is who we have been hearing is legitimately in the mix: Louis Leterrier, Will Eubank, F. Gary Gray. Other director who have been considered are…Deadline
Argo: The True Story That Inspired the Movie
Here's how Hollywood movie magic helped save lives in a hostage situation.Scripps Ulive
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EXCLUSIVE: Kilo Two Bravo director Paul Katis and writer Tom Williams have signed with Verve, the lit agency said today. The war drama, BAFTA nominated this past year when it was known as Kajaki: The True Story , recounts the story of a platoon set out to disable a Taliban roadblock. On nearing…Deadline
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Jeanne Tripplehorn, Callum Keith Rennie Join Cast of 'Little Pink House'
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AAC to MP3 Converter
editor's review
AAC to MP3 Converter is a software with a title that pretty much explains its functionality - it allows you to encode AAC files to the MP3 format. But you can also perform the reversed process.
If you're using Windows 7, then make sure to run AAC to MP3 Converter with administrative rights. Otherwise, a few errors will pop up during runtime.
The interface of the program is based on a simple window in which you can import audio tracks into the queue by using the file browser only, since the "drag and drop" method is not supported. Batch processing is allowed but you can add only one file at a time.
In the list you can check out the source path and size of each track. Once you specify the input file, output destination and filename, conversion is automatically initialized.
Unfortunately, there is no cancel button. In addition, you can delete an entry from the list, as well as preview audio tracks in a built-in media player.
The audio encoding tool runs on a low-to-moderate amount of system resources, quickly finishes a task and manages to keep a fair sound quality. No errors have occurred during our tests and AAC to MP3 Converter did not freeze or crash. It may take a while to play songs, depending on the file's size.
However, AAC to MP3 Converter doesn't let you configure any settings regarding the audio stream (e.g. sampling rate, bit rate, volume, channels) or the program itself (e.g. enable to automatically run at system startup or to minimize to system tray). We recommend AAC to MP3 Converter with reservations.
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Edit hours
Qdoba is a Mexican kitchen where guests can enjoy fresh, handcrafted meals prepared in front of them. Each Qdoba showcases unique flavors, like our famous 3-Cheese Queso & Ancho Chile BBQ sauce. With a variety of unique menu items, everyone can find a culinary creation sure to ... (See all)
Sooo good😋
Great breakfast burritoes
Mexican Gumbo with Pico de Gallo on Pinto Beans is so good!!!
Free WiFi !!!
Drunk watching on the.overnights (school year only) is great fun.
@Tim S.: I agree. I think the mayor ought to have first dibs (not me yet, but I'm hoping to get there!).
There is only one outlet in the entire seating area... So, not a great place to do work for an extended time.


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Every Day I'm Photographing #61/
Lunch at Orange Izakaya.
Lunch at Orange Izakaya.
Last night I went to the CJTR Radiothon wrap-up party. I left before the night was through - who can keep up with community radio supporters when their blood rises and the moon creeps up in their eyes? - but managed to capture the Bystanders and the Ben Templeton Trio. The Royal Red Brigade played as well, but I'm old and stuffy and the methamphetamine was wearing off, so home I went.
Concerts are so blue and red. It's like you're stuck in a musical paddywagon with beer and hickory sticks.
Oh nighttime, nightime/ Sneakin' out the back with a tripod/ Hey/ Nighttime, nightime/ Not a lot to rhyme with tripod
Behold the power of Velvia on a bright fall afternoon.
Presented without comment.
Regular visitors to this site may think that my photography is limited to wandering around the streets of this city and taking pictures of garbage and people (but not garbage people - they're up too early). But every so often I pull out lights and backdrops and do some grade-A professional headshot-style photography.
For example: this is Jill, who needed headshots for her new job. One speedlight, a looming bat of an umbrella and a portable backdrop.
I took a lot of shots of Jill, but she looked most relaxed with her head at a slight tilt. So there you go.
And Rolli! I shot him at The Artful Dodger with a combination of window light and a softbox (note the square catchlights in his eyes) on a stick. And a camera. I used one of those. Cameras are so useful for those moments when you want to take a photograph.
My first impulse with portraits is to blast the subject's face with light and banish all shadows to the land of wind and ghosts, but I let the edge of Rolli's face fall into shadow, because mystery. We also wanted to imply that he could snap off his chin and throw it with deadly force at his enemies.
Do you want to wear a lycra bodysuit and a harness and do a superhero pose on top of a building? Because I'll photograph that bidness.
And this is hard to see, but you're looking at a man dressed up as Darth Maul suspended from a 21-story building. You probably want context. Perversely, I refuse to deliver it.
Okay, it was for the Easter Seals Drop Zone charity event. People were rappelling down the face of Hill Tower in downtown Regina. I rappelled at the end of the day and discovered that I wasn't afraid of heights, but the harness, which had been used all day, smelled like the concentrated panic of dozens of spandex-clad adventurers. Not too pleasant.
A note on all the gear: Jill Pacholik shot with an Olympus OM-D E-M5 and Olympus 45mm f1.8. Rolli shot with a Fujifilm X100S. Drop Zone guy #1 shot with a Fujifilm X100T and Sneakers Darth Maul with the E-M5 and Panasonic 35-100mm f2.8.
Sometimes the best you can hope from the world is a bit of texture. It's like that spike of ketchup on the grey greasy fries of existence.
But as always, there's more going on than texture. There's Jenelle, making puttanesca sauce on the barbecue somehow. There's a false owl, set atop the patio umbrella to intimidate stray pigeons. Then there's the unexpected symmetry of windows above and below the balcony. Yeah, that's okay.
This is Mike. He lives in Yesterday. Yesterday is a place where the sun is out and the weather is just warm enough, where a fresh beer has just been placed on the table for you and there's a snake to hang out with.
Not far from there is an alleyway with a puddle that's just been disturbed and a truck that waits for someone to emerge from a hidden doorway.
Good old sunny inaccessible Yesterday. I think I left my keys there.
This morning I was a guest on The Morning Edition to talk about restaurants (let us say, the restaurant scene) in Regina. Anyway, while I was waiting for someone to come and get me, I poked around the lobby and discovered that the CBC building had a scale model of itself on display. A tiny CBC!
And inside this tiny CBC building is a legion of tiny broadcasters making tiny content for their tiny audience. News, I imagine, about insects and mice and the fake trees out front. What a great gig that would be.
My friend and former colleague at MamaPop.com, Anastacia Campbell, committed suicide yesterday. She was an exceptional human being: warm, imaginative, funny as hell and just a bit demented. My Facebook timeline is a flood of sadness, memory and gratitude.
During our time at MamaPop, Stacy appeared in a few of our video roundtables, which I put together every other week. I'm still tracking some of them down. But here's one of them: the "Imaginary Friends/Wish They Were Real" Edition, featuring Stacy in a pair of pink goggles. She shows up at the 1:35 mark to talk about friendship, good hair and Perfect Strangers.
And here's the possibly more coherent group lipdub of Miley Cyrus' "Party In the U.S.A."
If you're struggling with depression and thoughts of suicide, stop before you do something drastic and talk to someone. Schmutzie's post on suicide is a wonderful resource and I urge you to go there. And remember Stacy, because she is only memories now, and she should be here with us.
Let me be frank: I don't like this picture. It raises my hackles so much that I misused a colon in the previous sentence. I'm willing to betray my years of Englishing to express my dislike and even drop a comma splice, that's how much I don't like this picture. I hate the drooping leaves with their off-colours in the background, I find the foreground fussy, and this guy refused to open his eyes properly (probably because the concrete dust was bothering his eyes. Why isn't he wearing safety goggles?). But there you go.
These are the kinds of images that I file under 'missed opportunities'. I wanted to capture the man hunched over his machine, with concrete dust and smoke billowing out behind him. But I tried to be stealthy and sacrificed a better composition. And in truth, I tried. I moved around to the opposite side, but by that point he realized that I was trying to shoot him (sometimes I ask before I take someone's photograph, but I didn't want to distract this guy while he was handling heavy equipment) and was giving me a weary look, as if to say This job sucks and you think it's entertainment, asshat. So off I went.
Autumn here arrives quickly and doesn't stay long. These brilliant glowing yellows will be gone before the end of next week.
I'm posting photos because otherwise I'll put up my essay on the Fantastic Four movie. So please accept these images of the world's least inspired water fountain.
This fountain is just a big dark rock outside the Salvation Army with a halfhearted burble of water.
The stick is new. I doubt it's official, though.
This one looks like a bear! Very considerate of this complex, constantly shifting liquid shape to present itself in an ursine configuration. I almost feel bad for casting judgement on this thing.
This is Leonard the Friendly Snake. He's good at staring into the lens at the right moment. He lives at the Prairie Dog offices.
Also in the picture: my hairy knuckles, which Leonard probably mistook for underbrush.
If you're curious about the brute material conditions of this photo, I took it with my Fujifilm X100T with the aperture set to 2.8. This particular photo demonstrates the characteristics of the 23mm lens when you get in close - the out-of-focus parts of the image take on a glowy, hazy quality (also note the abrupt transition across the focal plane, which I'm not a big fan of). I applied a bit of dehazing to up the contrast and generally get the most Leonard out of the image that I could muster.
When you commit to shooting and posting a photograph every day, there are times when you have to reckon with your limits. Mostly your limits of laziness and capriciousness.
My city is becoming so fashionable lately that even the infrastructure is getting all haute. For example, this fire hydrant has decked itself out in a black crepe scarf:
And this potted plant is sporting an asymmetrical hipster haircut.
What's next? Bollards with waxed moustaches and knitted caps? Streetlights that blink on in the evening and peer at you through your bedroom window? Wait, that sounds like regular infrastructure.
Katie by night. What's she doing out at night? Is that the SaskPower building supplying those delightful lights in the background? What are those two people on the left talking about? No one will ask her. So we never know, swinging our load of ignorance over our shoulder and shambling home.
I mean, whoa. There's a tiny man crawling around on my face. I thought I wouldn't have to deal with this kind of thing up here on my billboard, but I guess indignity doesn't care about altitude.
At least it's more entertaining than staring at that blank black rectangle all day.


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Identifying bacterial genes and endosymbiont DNA with Glimmer
Arthur L. Delcher1,*, Kirsten A. Bratke2, Edwin C. Powers3, and Steven L. Salzberg1
1Center for Bioinformatics & Computational Biology, University of Maryland, College Park, MD
20742, USA 2Smurfit Institute of Genetics, University of Dublin, Trinity College Dublin, Dublin 2,
Ireland 3Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore,
Motivation: The Glimmer gene-finding software has been successfully used for finding genes in
bacteria, archæa and viruses representing hundreds of species. We describe several major changes
to the Glimmer system, including improved methods for identifying both coding regions and start
codons. We also describe a new module of Glimmer that can distinguish host and endosymbiont
DNA. This module was developed in response to the discovery that eukaryotic genome sequencing
projects sometimes inadvertently capture the DNA of intracellular bacteria living in the host.
Results: The new methods dramatically reduce the rate of false-positive predictions, while
maintaining Glimmer's 99% sensitivity rate at detecting genes in most species, and they find
substantially more correct start sites, as measured by comparisons to known and well-curated genes.
We show that our interpolated Markov model (IMM) DNA discriminator correctly separated 99%
of the sequences in a recent genome project that produced a mixture of sequences from the bacterium
Prochloron didemni and its sea squirt host, Lissoclinum patella.
The genomes of bacteria, archæa and viruses are very gene-dense, with protein-coding regions
typically comprising 90% or more of the DNA sequence. As a consequence, the accuracy of
prokaryotic gene-finding programs depends primarily on identifying which of the six possible
reading frames contains the true gene (Besemer and Borodovsky, 1999; Borodovsky and
McIninch, 1993; Guo et al., 2003; Ouyang et al., 2004). The accuracy of gene finding systems
in these species is very high as compared to eukaryotic gene finders; previous versions of the
Glimmer system had a sensitivity of 99% or higher (Delcher et al., 1999; Salzberg et al.,
However, there is still some room for improvement. First, the measurement of sensitivity relies
on comparisons to well-annotated bacterial genomes, where the best we can do is to count how
many 'known' genes are found by a gene finder. Genes are considered known if they have
clear homology, as measured by amino-acid similarity, to genes in other species. This similarity
often breaks down near the 5′ end of the transcript, which also tends to be the region where
© 2007 The Author(s)
*To whom correspondence should be addressed.
Contact: firstname.lastname@example.com
Associate Editor: Alfonso Valencia
Availability:Glimmer is OSI Certified Open Source and available at http://cbcb.umd.edu/software/glimmer
Conflict of Interest: none declared.
NIH Public Access
Author Manuscript
Bioinformatics. Author manuscript; available in PMC 2008 May 19.
Published in final edited form as:
Bioinformatics. 2007 March 15; 23(6): 673–679. doi:10.1093/bioinformatics/btm009.
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Page 2
gene finders disagree on the precise position of the start codon. Thus, one area where gene
finders might still improve is in prediction of start sites, as has been pointed out in previous
studies (Besemer et al., 2001).
A second issue is false positives, i.e. gene predictions that do not correspond to genuine protein-
coding genes. Because bacteria are so gene-dense, it is very difficult to say with confidence
that any gene predicted to lie in an otherwise intergenic region is false. Fortunately, the growing
number of sequenced genomes from closely related species does provide some help with this
question, and indeed some microbial gene-finding systems rely on database searches to identify
genes (Badger and Olsen, 1999; Frishman et al., 1998; Larsen and Krogh, 2003; Nielsen and
Krogh, 2005). If a predicted protein is not conserved between closely related species, then
evolutionary arguments can be made that the prediction is false. A greater source of false
positives in earlier releases of Glimmer, though, came from predicting too many overlapping
genes. Because truly overlapping genes are quite rare in bacterial genomes, the system should
generally avoid such predictions. Here too, homology to other species can resolve the question
of which gene is correct. Our challenge was to reduce the false positive rate of Glimmer without
sacrificing its high sensitivity (true positive) rate.
The new Glimmer, release 3.0, achieves a dramatically lower false-positive rate, predicts many
more start sites correctly, and maintains its high true positive rate. It does this through a new
algorithm for scanning coding regions, a new start site detection module, and an overall
architecture that for the first time integrates all gene predictions across an entire genome. In
addition, a new automated training program produces substantially improved training sets,
particularly on genomes with high GC-content.
We also introduce a new use for the interpolated Markov model (IMM) that is at the core of
Glimmer. Recent large-scale sequencing projects of eukaryotic species have inadvertently
captured the genomes of bacterial endosymbionts as a side effect of the overall project
(Salzberg et al., 2005). When a eukaryotic species has an intracellular endosymbiont, as is true
for many invertebrates including fruit flies, mosquitoes and nematodes, then a whole-genome
shotgun sequencing project cannot avoid capturing some of the symbiont DNA. Consequently
there is a need to identify and separate the DNA from the host and the symbiont, in order to
assemble the two genomes separately (and correctly). Besides these eukaryotic genome
projects, a growing number of bacterial sequencing projects are targeting endosymbionts that
can only be grown inside their hosts, including Wolbachia pipientis (Wu et al., 2004) and
Prochloron didemni (J. Ravel, personal communication). In these projects, despite
investigators' best efforts to isolate bacterial DNA, a considerable amount of eukaryotic host
DNA remained in the sample and needed to be removed. Motivated by these problems, we
developed a new algorithm in which the IMM within Glimmer is trained separately on host
and endosymbiont DNA, and then turned into a classifier to separate the raw sequences. We
report here on this new module and its successful use in two recent genome projects.
The Glimmer 3.0 package is distributed as OSI Certified Open Source software and is freely
available at http://cbcb.umd.edu/software/glimmer
2.1 Reverse scoring
The IMM scoring algorithm in Glimmer computes the log-likelihood that a given interval on
a DNA sequence was generated by a model of coding versus noncoding DNA. This model
represents the probability of a nucleotide given a subset of positions in a window (called the
context) adjacent to the nucleotide—for details, see (Delcher et al., 1999; Salzberg et al.,
1998). Glimmer 3.0 takes advantage of the flexibility of this algorithm by scoring all open
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reading frames (ORFs) in reverse, from the stop codon back toward the start codon, with the
probability of each base conditioned on a context window on its 3′ side and the score of the
ORF being the log-likelihood sum of the bases contained in the ORF. The score is computed
incrementally as a cumulative sum at every codon position in a given ORF. In many cases,
these scores show a marked peak in value, and furthermore this peak typically occurs near the
correct start site (see Fig. 1 for an example). The advantage of scanning ORFs in reverse is that
for nucleotides near the start site, the context window of the IMM is contained within the coding
portion of the gene, which is the type of data on which it was trained. This results in a more
precise cumulative score at nucleotides very close to the start site, compared to a context
window on the opposite side which would intersect a non-coding region.
As the figure shows, the cumulative IMM score steadily increases as we move away from the
stop codon at the left until it reaches a peak and then begins to decline. The decrease occurs
because the bases upstream of the gene start codon are non-coding and produce negative IMM
log-odds scores. The figure also shows, as vertical dashed lines, the positions of all possible
start codons in the ORF. We hypothesized that if we used the highest-scoring start codon in
these plots, then Glimmer would find a higher percentage of true start sites. This is borne out
in our experiments, described subsequently.
An important difference between this algorithm and earlier versions of Glimmer is that, unlike
those versions, which had a strong bias in favor of longer ORFs, this algorithm chooses start
sites based on their relative scores.
2.2 Ribosome binding sites
In previous versions of Glimmer, the ribosome binding site (RBS) was essentially ignored,
even though it provides a strong signal for the position of the true start site. We addressed this
problem with a standalone program, RBSfinder, that can be run as a post-processor on the
results of Glimmer's analysis. RBSfinder is quite effective at finding ribosome binding sites
and adjusting Glimmer's predictions (Suzek et al., 2001), but we nonetheless felt that a better
design would integrate RBS evidence directly into the gene-finding algorithm. Glimmer3 now
contains this long-awaited integration.
After experimenting with several alternative algorithms, we found that the ELPH software
(http://cbcb.umd.edu/software/ELPH) was highly effective at identifying the likely RBS in
most bacterial genomes. Input to ELPH is a specified motif length and any set of sequences,
in which it identifies likely shared motifs using a Gibbs sampling algorithm. ELPH produces
a position weight matrix (PWM) that Glimmer3 then uses to score any potential RBS. If a
substantial set of training genes is available, the regions upstream from their starts can be given
to ELPH to produce a PWM. Otherwise, Glimmer3 can bootstrap itself by first running without
a PWM, generating a set of gene predictions, and then extracting regions upstream of those
predictions as input to ELPH. Glimmer3 can then be re-run with the PWM to produce a more
accurate set of start-site predictions. The entire process can be iterated as desired until a
consistent PWM and set of gene predictions result. This strategy of using a Gibbs-sampler to
find RBS motifs in an iterative fashion was introduced in the GeneMarkS gene-finding system
(Besemer et al., 2001).
2.3 Reduced overlapping predictions
Both Glimmer2 and Glimmer3 start by identifying open reading frames (ORFs) with
sufficiently high IMM scores to be processed further. In many cases, these ORFs overlap by
more than the (user-specified) maximum allowed distance, indicating that only one of them is
a true gene. Glimmer2 uses a series of rules based on ORF lengths, ORF scores and the IMM
score of the overlapping region to attempt to resolve these overlap cases. When the rules do
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not produce a clear conclusion, however, Glimmer2 outputs both ORFs with an annotation
indicating the overlap. As a result, Glimmer2 can have a high false-positive rate, particularly
for high-GC genomes, which have large numbers of overlapping ORFs.
In contrast, Glimmer3 begins by assigning a score to each valid start position within an ORF.
This score is the sum of RBS score plus the IMM coding potential score plus a score for the
start codon (determined by the relative frequency of each possible start codon in the same
training set used to determine the RBS). Each possible start codon is linked to the stop codon
that terminates its ORF.
A global dynamic-programming algorithm is then used to select the set of ORFs and start sites
with maximum total score across the entire input sequence, subject to the constraint that no
overlaps greater than a specified maximum are allowed. Specifically, the set of potential start
sites and stop positions is scanned in sorted order by location on the input sequence. At each
start or stop feature f, the score of the maximum-scoring set of genes up to and including f is
computed as the maximum compatible prior score in any of the six reading frames plus the
score of f. Because overlaps are allowed, the value for a feature f may, in fact, change as the
result of a feature encountered after f. To accommodate this case, our algorithm backtracks to
update scores within the maximum allowed overlap distance and adjusts the scores to avoid
double counting the score of the overlap region. Because the maximum overlap distance is
typically small compared to the average gene length, the additional cost is usually insignificant.
In many respects this algorithm functions like the hidden Markov models (HMMs) used in
other gene-finding programs such as GeneMark.hmm (Lukashin and Borodovsky, 1998) and
EasyGene (Larsen and Krogh, 2003). The principal differences are that small overlaps between
genes are allowed (without resort to a complicated set of overlap states in an HMM) and that
potential coding regions are prescored by the IMM in the stop-to-start direction so that the
scanning direction of the algorithm effectively alternates on different segments of the sequence.
The result is that the final set of Glimmer3 predictions contains no overlaps greater than the
specified maximum, and the total number of Glimmer3 predictions is almost always less than
the corresponding number of Glimmer2 predictions.
2.4 Improved training with long-orfs
One of Glimmer's strengths has always been the ease with which any user can automatically
train it on a new genome. The long-orfs program in the Glimmer system is used to create a
training set of genes from a genome by selecting ORFs above a threshold length that do not
overlap other ORFs above that threshold length. The threshold length is computed by the
program to be the value that maximizes the number of non-overlapping ORFs produced, thus
maximizing the amount of data in the training set. For most genomes this approach is quite
effective, typically producing a training set containing nearly half of all genes with relatively
few ORFs that are not genes. In the case of high-GC genomes (>60% GC), however, the scarcity
of stop codons results in an abundance of long ORFs that are not genes. For such genomes, the
version of long-orfs in Glimmer2 produces very small output sets, with many incorrect
To overcome this problem, the long-orfs program in Glimmer3 incorporates a new routine
to filter the initial set of ORFs based on amino-acid composition. Here we wish to take
advantage of the fact that the genes in widely disparate bacterial genomes tend to use a common,
universal amino acid distribution (Luscombe et al., 2001; Pascal et al., 2005). By comparing
the ORFs found by long-orfs to a universal distribution, we should be able to eliminate many
ORFs that are highly unlikely to be protein-coding genes. Specifically, we compute the
distribution of each ORF's amino acids and compare it to both a positive model derived from
a large sample of microbial genomes, and to a negative model created from alternative reading
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frames of those genes. We then compute the ratio of the distance of the candidate ORF's
distribution to the positive and negative models, and only those ORFs whose ratio is below a
user-specified threshold are passed on to the length- and overlap-calculation stage. These
distance calculations are actually computed using the entropies of amino-acid distributions as
described in (Ouyang et al., 2004).
Table 1 compares the output of the Glimmer2 and Glimmer3 versions of long-orfs to the
set of all annotated genes for a sample of 13 bacterial and archæal genomes obtained from
NCBI (Wheeler et al., 2006). Note how for the high-GC (67%) Ralstonia solanacearum
genome, Glimmer2's long-orfs outputs only 288 ORFs, of which a mere 55% match
annotated genes. In contrast, Glimmer3's long-orfs identifies 1175 ORFs, 96% of which
match annotated genes.
2.5 Gene prediction accuracy
In order to test the effect of the improvements in Glimmer3, we compared it to several different
sets of data, shown in the tables. First, we compared its predictions on a sample of complete
genomes to the 'known' genes from those genomes. We used NCBI annotation to determine
when a gene was known, by simply removing all genes annotated as 'hypothetical' from the
set of known genes. Genes assigned a function are in most cases closely homologous to genes
from other genomes, which provides independent evolutionary evidence that these genes are
real. We are aware that this method has its shortcomings, but no other method yields nearly as
many genes for testing. This method also does not guarantee that the start codon is correctly
predicted, because homology does not need to extend for the full length of a predicted protein
in order to be considered adequate evidence for assigning function.
Another important test of Glimmer 3.0 was its comparison in relation to Glimmer 2.13, and
we, therefore, ran both algorithms on the same set of genomes. In Table 2 we show the accuracy
results of both Glimmer2 and Glimmer3 on our benchmark genome sample. Both algorithms
were trained and tested on the same data set of non-hypothetical genes in an eight-way cross-
validation experiment. (For each genome, the genes were divided into eight approximately
equal-size subsets. One subset was held out for testing and Glimmer was trained on the
remaining subsets. This was repeated eight times so that each gene was part of one test set.)
As shown in the table, Glimmer3 nearly always achieves equal or higher sensitivity than
Glimmer2, but with far fewer additional predictions, indicating much greater specificity.
Glimmer3 also has far greater agreement between its start codon predictions and those in the
benchmark genomes: in 11 of the 13 genomes, it has greater agreement than Glimmer2. For
example, in Bacillus anthracis Glimmer3 predicts 726 start sites that agree with the NCBI
annotation but disagree with Glimmer2. Note too that we cannot guarantee that the start sites
are correctly annotated for any of these genomes, but without further laboratory evidence these
are the best data available. Table 3 compares the results of running both Glimmer2 and
Glimmer3 using the output of their respective versions of the long-orfs program to produce
a training set. As before, the predictions are compared to non-hypothetical genes in the
annotation. In this case, Glimmer2's performance is substantially worse because of errors in
its long-orfs output. Glimmer3's performance, however, is substantially the same as when
it is trained with annotated data, indicating that it is likely to do well even in the absence of a
pre-computed set of 'known' genes for training.
Table 4 compares Glimmer3 predictions to those of three other gene-finders, GeneMark.hmm,
EasyGene (Larsen and Krogh, 2003) and GeneMarkS (Besemer et al., 2001), and shows that
Glimmer obtains comparable results. These other systems all run through web servers or by
downloading precomputed predictions, and EasyGene uses homology-search results to help
determine its parameters. In contrast, Glimmer runs locally and offers many options for
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text:
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text:
Automotive Digital Marketing ProCom
Professional Community for Car Dealers, Automotive Marketers and Sales Managers
Added by Mike Warwick on October 29, 2011 at 7:20am — 6 Comments
A message to the Beverly Hills Porsche sales staff:
Anyone that's been in the car business for a while knows how much our business has changed. The internet came along and WHAM, customers are now better educated, more demanding and quicker to throw up objections based on something they picked up on the internet.
But one…Continue
Added by Jay Huffschmidt on October 28, 2011 at 5:28pm — No Comments
Dos and Don'ts of using QR Codes.
QR Codes came out in 1994, however only in the past year have they become more popular and widely used. We can thank the smartphone explosion for that– there are now more smartphones sold than personal computers. 90% of people keep their phones within 3…
Added by Jessica Wolf on October 28, 2011 at 1:47pm — No Comments
Added by Arnold Tijerina on October 28, 2011 at 9:16am — No Comments
The amount of "best practices" and "tips" involved with social media marketing can be overwhelming to say the least (and yes, I'm guilty of sharing my own). In the spirit of KISS (Keep it Simple, Stupid), here is a short list of Must-Do's for dealerships using social media as a part of their online marketing efforts:
Added by Ali Amirrezvani on October 28, 2011 at 6:56am — No Comments
Added by Ralph Paglia on October 27, 2011 at 7:30pm — 1 Comment
Your dealership's website has a contact form and phone number, but does it have an online chat function? If it doesn't, then you're missing out on the newest way to engage online car buyers. Since people visit your website at different times during the day, they're not always ready to call or submit information…Continue
Added by Mina K. on October 27, 2011 at 2:00pm — 2 Comments
Customer satisfaction and customer retention are paramount for a dealerships long term success!
So…..how can you make sure that your entire team understands this and performs at its highest level??
You HAVE to build a culture!
Here is a link to a blog that I wrote about building a culture:
Added by Jim Kristoff on October 27, 2011 at 1:02pm — No Comments
What To Do About A Bad Review
We've all talked about bad reviews and what to do about them. The consensus is that you answer them in a constructive way that shows others that you are concerned about an unhappy customer.
Asking that customer to…Continue
Added by Tom Gorham on October 27, 2011 at 10:00am — 74 Comments
Added by Arnold Tijerina on October 27, 2011 at 9:00am — No Comments
In my days with HomeNet Automotive, a new feature was released that allowed our customers to upload live video into their inventory for distribution to the third-party websites that would allow it.
Being in sales, I wanted to have a real video in which I could show potential clients the possibilities and an actual example of what one would look like so I enlisted help from a friend of mine who's a GM at a nearby dealer group to…Continue
Added by Arnold Tijerina on October 27, 2011 at 7:32am — 2 Comments
Added by TERRY GIBSON on October 27, 2011 at 7:00am — 1 Comment
Added by Ralph Paglia on October 26, 2011 at 10:00am — No Comments
Added by J.D. Rucker on October 26, 2011 at 9:10am — 1 Comment
Pay-per-Click (PPC) maps well to what we've done for years on our lots, but we don't realize it: We spend a lot of money getting visits and calls to a dealership, and we train our salespeople to land a customer on a car before starting the negotiation process in the store. Get'em "lickin' the paint" as my first GSM…Continue
Added by Keith Shetterly on October 26, 2011 at 8:30am — 4 Comments
Automotive chat leader, Contact At Once! Announces Top 15 Most Talked About Fuel Efficient Vehicles. Topping the list: Toyota Prius, Lexus CT 200h and Chevrolet Volt.
Contact At Once! Auto Dealer Chat, the leading chat provider to the…Continue
Added by Aaron Hassen on October 26, 2011 at 6:58am — 2 Comments
Practice the Art and Science of Marketing Orchestration
This is the second part of our series regarding how to make various marketing communication channels operate in a coordinated fashion to forge a seamless 'one-sight-one-sound' campaign.
Think about dealership assets—your customers
Opportunities exist every day of the week for you to make a vehicle sale or make a vehicle…
Added by Joseph Little on October 26, 2011 at 6:44am — No Comments
Every business that has offered a loyalty rewards program has seen a variety of responses to every reward offered. Some rewards are rarely – if ever – redeemed by members, while another reward may seem to be the only reward members want. And while we may switch out unused rewards for others we see as more valuable, the success of that reward will likely remain low unless we've evaluated and employed the characteristics of highly successful rewards in our own reward selection.
Added by Mike Gorun on October 25, 2011 at 9:02am — No Comments
Having videos on your auto dealer website has been shown to increase website leads, and when done with video search engine optimization (VSEO), helping your site climb the search engine result pages. If your dealership has videos on your website, you should have those videos uploaded to your own dealership YouTube channel.
Here's why:
Added by Ali Amirrezvani on October 25, 2011 at 8:57am — 2 Comments
Added by Aaron Hassen on October 24, 2011 at 7:30am — 3 Comments
© 2015 Created by Ralph Paglia.


text:
Internal Medicine Clerkship Guide
- Douglas Paauw, MD, Professor of Medicine, Division of General Internal Medicine, Coordinator for Student Teaching, Rathman Family Foundation Endowed Chair for Patient Centered Clinical Education, Department of Medicine, University of Washington School of Medicine, Seattle, WA
- Lisanne Burkholder, MD, MPH, Assistant Clinical Professor, Division of General Internal Medicine, Associate Program Director, Primary Care Internal Medicine Residency, University of California School of Medicine, San Francisco, CA
- Mary Migeon, MD, Assistant Professor, University of Washington School of Medicine, Seattle, WA
Here's all the help you need to survive your internal medicine clerkship! This handy guide offers you practical, must-have guidance on the causes, clinical evaluation, and treatment of common medical conditions—knowledge that every student can and should master. Section 1 outlines the practical skills and procedures you must know on rotation; Sections 2 and 3 describe health conditions organized by presentation (symptom, sign, abnormal lab value) and by specific diagnosis, allowing you to approach a given health problem from either direction.View full description
3rd and 4th year medical students
Book information
- Published: September 2007
- Imprint: MOSBY


text: Lara Pizzorno Lara Pizzorno, M.A., L.M.T., is a health writer and medical editor with more than twenty years of experience. Become a Fan × BECOME A FAN Get updates about Lara Pizzorno and recommended reads from Simon & Schuster. Plus, get a FREE eBook when you sign up! Email Address Free eBook available to NEW subscribers only. Offer redeemable at Bookshout.com. Code expires 12/31/2015. See full terms and conditions. By clicking SIGN UP, I acknowledge that I have read and agreed to the Privacy Policy and the Terms of Use. Books by this Author Encyclopedia of Healing Foods By Michael T. Murray and Joseph Pizzorno By Michael T. Murray and Joseph Pizzorno Encyclopedia of Healing Foods From the bestselling authors of The Encyclopedia of Natural Medicine, the most comprehensive and practical guide available to the nutritional benefits and medicinal properties of virtually everything edible.As countless studies have affirmed, diet plays a major role in both provoking and preventing a wide range of diseases. But just what is a healthy diet? What does the body need to stay strong and get well? In The Encyclopedia of Healing Foods, Michael T. Murray, N.D., and Joseph Pizzorno, N.D.,... Read more about this book Read more Get a FREE eBook when you join our mailing list. Plus, receive updates about Lara Pizzorno,recommended reads and more from Simon & Schuster. Email Address Free eBook available to NEW subscribers only. Offer redeemable at Bookshout.com. Code expires 12/31/2015.See full terms and conditions and this month's choices.


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A majority of likely Republican voters plan to tune in to the first GOP presidential debate Thursday night, even if they don't believe it is likely to have a major impact on the outcome of the party's primary.
Author: Sam Rolley
Just stay home if 2016 brings another Bush-Clinton election
According to a new analysis of Federal Election Commission filings, 17 of the nation's wealthiest citizens have donated to both Hillary Clinton's and Jeb Bush's presidential campaigns.
Students say kick cops out of union because … racism
It's always fun to watch liberal utopia melt down in real time. Here's a good one: from the intersection of big labor and racial oversensitivity.
Anti-gun activists claim a 'civil right' to abuse the 2nd Amendment
A group of Chicagoans is suing nearby local governments, claiming Chicago residents have a "civil right" to force the city's strict gun control laws on other locales.
With little stigma, police kill thousands of innocents during high speed pursuits
Newscasters should stop using chases to pad ratings, viewers should find their suspense elsewhere and police officers should eliminate high speed pursuits from their law enforcement tool bags once and for all.
Artificial wage inflation is bad for everyone
Some economists are warning that a drastic minimum wage hike could have dire circumstances for the American workers who need the money most.
Donald Trump, without apology, fights 'like hell' to keep his money out of government hands
In an interview Sunday, Donald Trump, who has yet to make public his tax returns, eschewed the "fair share" argument that many politicians on both sides of the aisle bring to the tax debate, saying that — like all U.S. taxpayers — it's in his best interest to pay as little as possible.
Charles Koch calls for political change at donor summit; Trump says candidate attendees are 'puppets'
Billionaire Charles Koch on Sunday told 450 business leaders, politicians and GOP donors that America is "done for" if conservatives don't do a better job building support for smaller government.
Polling shows Donald Trump a huge threat to the GOP establishment
Donald Trump holds a commanding 9.5 point lead against his fellow Republican hopefuls. But that number could be the least of the GOP establishment's worries.
Ben Carson vows to make term limits for Congress a reality
GOP presidential candidate Ben Carson has pledged support of a constitutional amendment to impose congressional term limits, saying the move will "create more opportunities for fresh ideas" in the nation's halls of power.
Kentucky man faces felony charges for protecting privacy by shooting drone hovering over his backyard
A Kentucky homeowner is facing two felony charges after he shot down a drone that he says was hovering above his property.
It cost taxpayers millions to send Obama to Kenya
President Obama's flight to Kenya and Ethiopia cost U.S. taxpayers $6 million, according to an analysis of the president's prolific globe-trotting. But the total cost of the trip is much higher.
Bernie Sanders: Open-border policy is a right-wing idea
In a recent interview, Vermont senator and presidential hopeful Bernie Sanders said that the open-border immigration policies often championed would make all but the wealthiest Americans poorer.
Did Hillary Clinton, middle-class champion, just get a $1,200 hairdo?
Hillary Clinton and her entourage recently took a break from trying to convince America she's just an average gal and shut down a portion of the luxury Manhattan-based department store Bergdorf Goodman so the candidate could get a haircut.
Intelligence officials use 'lone wolf' terrorists to justify calls for more spying power
On Tuesday, Director of National Intelligence James Clapper called for changes that would make it easier for the government to keep tabs on individuals.
The political establishment is terrified because Trump knows what he's talking about
Rush Limbaugh said Republican lawmakers are happy to join media and Democratic condemnation of Donald Trump because they're all upset that he doesn't adhere to the unspoken rules of the conventional political dichotomy.
Hillary Clinton: You've got to elect her to find out where she stands
Democratic presidential candidate Hillary Clinton is notoriously keen on avoiding questions of substance from members of the press. But her latest non-answer to a citizen's question about the Keystone XL pipeline takes Clinton question-dodging to a new level.
RNC chair wants no-third-party promise from GOP candidates
Republican National Committee Chairman Reince Priebus wants GOP presidential hopefuls to pledge not to run third-party if they aren't selected as the establishment's presidential choice.
Liberty groups want you to bombard Capitol fax machines to make Internet privacy point
A coalition of online privacy advocates is asking Americans to protest an upcoming cybersecurity vote using technology even the most elderly lawmaker can understand: via fax.
Democrats fail big-time with attempt to satisfy the gods of political correctness
In the latest story about political correctness making people stupid, the Connecticut Democratic Party recently voted to rename its annual fundraising dinner to remove references to former presidents.
All the reasons Donald Trump is the most interesting man in the world right now
Recently there's been an explosion of anti-Trump talk from the GOP political establishment and mainstream media. But despite efforts to shut him up, Trump is everywhere.
Press 1 for outrage: Immigrants who reject English cost taxpayers billions of dollars
Rep. Sam Graves (R-Mo.) is slated to introduce the Cost of Services and Translations Act, or COST Act, this week in order to find out exactly how much the nation spends catering to foreign speakers.
The Cold War is back on
"Good morning, American pilots, we are here to greet you on your Fourth of July Independence Day," stated the crew of a Russian nuclear bomber that buzzed the U.S. 40 miles off the California coast on the Fourth of July.


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Scanica Furniture Warehouse is a business providing clean, recyclable and environmentally safe furniture in Concord, Ontario.
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Select Local Merchants
Sandi's Mane AttractionRead MoreWinter blues? Stuck inside? There's no reason to lose that beachy glow when you can head over to Keystone Heights' Sandi's Mane Attraction for tanning and more. Keep those pores clear with a relaxing facial courtesy of the salon's expert aestheticians. If you're looking for a sun-kissed glow, you'll love the salon's tanning services, including tanning beds, spray tan, and airbrush tan. Keep up with the latest and greatest hair trends at this salon, a highly-rated and fashion-forward establishment. You can make your nails an accessory to your outfit with a nail care treatment from this salon, such as no-chip gel manicures, pedicures, manicures, and nail art. When you step out of Sandi's Mane Attraction, everyone you see will be jealous of your perfect bronze glow.7381 State Road 21Keystone Heights, FL US
Salon LaviRead MoreNiles' Salon Lavi offers a peaceful facility for you to relax your mind and rejuvenate your body. Take a break from your long work week and enjoy a relaxing and nurturing facial at this spa. Pamper yourself with a long, relaxing massage from this spa and leave feeling refreshed. Painless and effective hair removal remedies, such as waxing, are available at this establishment. Salon Lavi has all of the beauty services to keep you looking your best. Come in today and try make up application. Transform your look with a refreshing cut by this spa. Pamper yourself with some of this spa's nail services, such as a pedicure or manicure. So when you're curious about the latest hair trends, pay Salon Lavi a visit and snag a new look.309 Vienna AvenueNiles, OH US
Tropitan Tanning CenterRead MoreGirard's Tropitan Tanning Center is perfect for experienced or first-time tanner. Seeking alternative medical services? Check out the selection at this salon, including acne treatment. Feel like it's summer all year long with this salon's full suite of amazing tanning services, such as tanning beds, spray tan, and airbrush tan. This salon happily accepts walk-in appointments for your convenience. Tropitan Tanning Center accepts Visa, MasterCard, Discover, American Express, and all major credit cards. Tropitan Tanning Center offers clean and natural-looking tanning solutions so book an appointment today and treat yourself to a beautiful glow.515 N State StGirard, OH US
Pro NailRead MoreA great gift for any girlfriends is a trip to Niles' Pro Nail, a professional nail salon only for the best! This establishment offers a wide array of nails services, such as no-chip gel manicures, pedicures, manicures, and nail art, to keep your nails looking clean and stylish. Don't worry about making an appointment; this salon also accepts walk-ins. Prices can be on the higher side here, so prepare to shell out a little more than average for your treatments. At Pro Nail, you can pay with any major credit card. Whether you want a fresh clean coat or cool nail art, the professionals at Pro Nail can give your nails the desired look.5555 Youngstown Warren RdNiles, OH US
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NY Police rescue woman from East River
Two New York Emergency Service Unit officers rescued a woman from the East River Wednesday when she was spotted floating near the Manhattan bridge.
Join the discussion
PoliceOne top 5
- 1 Video: Md. cop shoots, kills man who 'aggressively' advances towards him
- 2 SC cop shot, killed by suspect in mall
- 3 Sheriff: 9 killed, 7 injured in shooting at Ore. college
- 4 Numbers talk: Officers killed in the line of duty, people fatally shot by police
- 5 Fla. officer's finger nearly bitten off, suspect fatally shot


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With these two dominant forces in pop and dance, a musical collaboration on the slow ballad side is long overdue. The two can Instagram a picture of themselves in the studio for the near future to get fans wondering.
Photo Credit: Music Terra
Comments are closed.
The thirst is real…


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Hisense 200
Dover Intl. Speedway
CONCORD, N.C. (September 30, 2015) – Roush Fenway Racing drivers Ryan Reed and Chris Buescher will both sport Lilly Diabetes paint schemes this weekend at Dover.Read More
Reed has three career NASCAR XFINITY Series starts at Dover International Speedway. He recorded his best finish of 11th at the track in May of this year after starting 17th and fighting loose conditions throughout the race.Read More
CONCORD, N.C. (September 29, 2015) – American Diabetes Association® Youth Ambassador Sadie Davis will ride along with Roush Fenway Racing driver Ryan Reed during Saturday's NASCAR XFINITY Series race at Dover International Speedway.Read More
SPARTA, Ky. (September 27, 2015) – Roush Fenway Racing driver Ryan Reed and the No. 16 Lilly Diabetes American Diabetes Association team finished 25th on Saturday night at Kentucky Speedway after sustaining significant damage on Lap 2.Read More
Dover Intl. Speedway
Charlotte Motor Speedway
Cray Diabetes Self-Management Center at Kansas University Medical Center


text: We had reservations for 7:30pm, and arrived at 6:30pm for time on the back-patio for happy hour and relaxation. We had a nice patio table and were greeted promptly by our server, Ebony. She was pleasant, polite and efficient. I had a draft from a nice selection. My wife had a wine from an equally... read more


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Literature: My Uncle Oswald
My Uncle Oswald is a satire soft porn novel written by Roald Dahl (yes, that one) in 1979. The first part of the book took part in 1912 and the second part in The Roaring Twenties. The first part of the book is about Oswald's search for an aphrodisiac, and the second part his scheme to capture the genomes of every celebrity with the help of Arthur Woresley, a biology professor and Yasmin Howcomely, The Vamp.
This book features the following examples:
- A Date with Rosie Palms: Woresley used his own sperms when testing his freezer system, with which Oswald sympathizes deeply.
- Been There, Shaped History: Oswald's crew, who (almost) scandalized every male celebrity and crowned head in Europe and collected their sperms. Though, he gives himself no credit of any event.
- Black Comedy Rape: Really!
- The Casanova: Oswald - his nephew says Casanova is a monk in comparison.
- Darwinist Desire: Oswald collects the sperm of geniuses in order to sell it to women who want to have genius babies.
- Femme Fatale: Yasmin.
- Fictional Document: It's framed as the diary of Oswald, left to his nephew and only seeing the light of day now because its contents were too explosive, etc.
- Freud Was Right: Deconstructed in the most hilarious way.Ja ja, he said, writing all this down on my record sheet. It may interest you to know, fräulein, that the carrot and the cucumber are both very powerful sexuality symbols. They represent the masculine phallic member. And you are vishing either to chop it up or to pickle it!
- Note that the person speaking is Freud himself.
- Historical-Domain Character: Loads of them.
- Raging Stiffie: What happens 9 minutes after the victim swallows the beetle powder.
- The Roaring Twenties: The second half the book happens in this period.
- Sweet Polly Oliver: Yasmin has to dress up as a man to get the donation from Proust.
- Unfortunate Item Swap: Yasmin seducing men by feeding them an aphrodisiac-filled chocolate truffle, while eating a perfectly normal truffle herself? That has to go wrong at some point, and when she gets to the King of Norway, it does.His Majesty: Control yourself, madam!
- The Vamp: Yasmin, used this way by Oswald.


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Hotel Le Christiania
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Aqua Béarn
... tables "Eat your foie gras Isabel or no more rides!" After about 41/2 hours we dragged her away to visit the winery and buy more yellow freestone peaches just picked. Meg cooked big fillet steaks and spicey pumpkin soup, and of course fruit for ...
Our 5th Tour de France
... I began reading Chris Froome's 'The Climb'. Hearing the reports of spitting and booing from so-called Tour fans and insinuating discussions from French journalists, one of which was done for taking EPO whilst a pro, made the book all the more interesting and my belief in him even stronger. After all the documentaries and staged interviews with Armstrong last year, my passion for pro-cycling had changed; Froome and the SKY team have restored my belief. Yes, the Tour ...
Lucy arrives
We left Simon and Liv to hire a car in Pau and drove with Isabel 2h30 to Toulouse where we felt the need to play ladies at a tea shop in St Georges Square. The district is old and quaint with many shops for the large population. After watching My Fair Lady yesterday we knew how to behave. The ...
Hot Hard Hautecam and a fond TT farewell.
... beauty has cracked a few over the years.
The climb starts at 9% from the get go.....and is brutal, all the riders have been set off at one minute intervals, with the long handicaps away first and it is apparent some have pushed too hard too early including yours truly and the punishing gradient takes its toll and this is by far the hardest climb of the week .......maybe the ...
Oloron markets
Simon and Liv walked in quite steamy heat 7kms to town where we met to see the Oloron markets in the square outside the Mairie. This was a success for shoppers and traders alike as we bought mango chutney from the Indian hot food truck, duck confit in cans, duck foie gras, and plums, cherries and tomatoes to die for. ...


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Auto Repair in Devils Lake
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There are 15 auto service shops and mechanics in Devils Lake. Edit search
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Auto repair shops and dealerships near Devils Lake.
303 1st Ave, New Rockford
Muffler & Exhaust, Service & Repair, Tire Sales/Repair
"They do good work. Fair & honest. "
515 College Dr, Devils Lake
106 5th St NE, Devils Lake
400 Main St S, Tolna
206 1st St S, New Rockford
395 1st St N, Carrington
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610 Highway 2 E, Devils Lake
590 8th St N, Carrington
204 9th St, Cando
203 Vine Ave S, Fessenden
4905 37th St Ne, Maddock
8307 Highway 2, Devils Lake
332 Highway #2 West, Devils Lake
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302 Western Avenue, Maddock
6711 North Dakota 200, Carrington
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FreakScore is a weighted average of all aggregated professional and user review scores. Read more
This product has a FreakScore of 9.1* out of 10 based on 3 scores.
*Score is uncertain and deviates toward category average due to low number of scores.
The continuous adjustable 5 to 15-times magnification enables a Read more


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On The Scene: The 100 Best Nonprofits
|| Print |
|On the Scene
|Thursday, September 30, 2010
Over 500 guests attended the awards dinner for the 100 Best Nonprofits to Work For in Oregon at the Portland Downtown Hilton last night.
The night celebrated the winners of Oregon Business magazine's second annual survey grading nonprofit workplaces. Attendees were excited to find out their nonprofit's ranking, which was based on answers to survey questions by almost 5,000 employees.
Two of our reporters interviewed the top nonprofits back in August to find out what exactly made them a great place to work, but they couldn't reveal what number the nonprofits were in the ranking. Reporter Cory Mimms said he just told them he couldn't reveal their ranking over punishment by death by Editor Robin Doussard. The top nonprofits explained to our reporters what exactly made their nonprofits great places to work, but over drinks before the event, everyone time and again had the same answer: the people. "We're all like-minded people, having fun, doing what we love," said one Oregonians Credit Union employee.
At a time when unemployment in Oregon is seemingly perpetually stuck at 10.6%, nonprofits employ 12% of Oregonians working in the private sector. Clearly, nonprofits are vital to Oregon's economy, and making them a place where employees actually enjoy working is one step on the road to economic recovery.
When the awards for the top 10 nonprofits were announced, a short description of the workplaces preceded the names being called. As the audience heard about the quirks that made each nonprofit special, like the wands at the desks of Make-A-Wish Foundation employees, or the biggest-loser contest at Mary's Woods at Marylhurst with an $800 prize, whispers could be heard from around the room as employees realized it was their workplace being honored. "It's us!" was murmered excitedly many times throughout the night.
As nonprofits realized they had won and took to the stage to accept the honor, it was clear that although Oregon nonprofits may be filled with like-minded people, they are all different. For example, the number three best small nonprofit, the Northwest Pilot Project, has 17 employees that provide housing services for about 1,500 seniors. The employees range in age from 29-92. In fact, today is bookkeeper Dorothy Oreste's 92nd birthday- happy birthday, Dorothy!
Compared to the Oregon Entrepreneurs Network awards held at the same venue a week before, the crowd at the nonprofit awards was markedly different. The sea of black clothing last week before gave way to a crowd filled with many more women wearing brighter, happier colors. Executive director of number three best medium nonprofit Children's Nursing Specialties Barbara Wood wore a bright red jacket. "It's my power color," she joked as she got her picture taken on our makeshift red carpet.
The photo opportunity and much of the rest of the event is thanks to the creative genius of OBM Art Director Jon Taylor Carter, who helped plan everything down to the last detail, from music, to food to the candles. When planning a large event, the main priority is to make sure it seems like it goes off without a hitch, even when in the background anything can go wrong. "[Event planning] is hard because you're dependent on your vendors," he said. The "red carpet" area where guests took pictures in front of our 100 Best logo, and later, in front of the nonprofit cover, was definitely the hit of the evening. Be sure to check for those pictures on our Facebook page soon.
Besides taking photos in front of the larger-than-life cover, the highlight for us here at OBM was when the October issue was finally brought out to all the attendees. There's just something about having your magazine distributed to readers with fanfare (with lively music provided by the talented Clambake Combo) that closely resembles living the dream for journalists.
Don't miss the complete list of 2010's 100 Best Nonprofits to Work For in Oregon. Congratulations to all the winners.
Emma Hall is web editor for Oregon Business.
|The List: 100 Best Nonprofits to Work For in Oregon
|Run, Nick, Run
|100 Best Nonprofits: Working for equality inside and out
|Keep Pendleton Weird
|Salad Days
|One Tough Mayor
|Big Geek
|Portland-raised NFL star to launch Nike store at alma mater
|SABMiller agrees to merge with Budweiser
|LeBron signs with 'the Chipotle of pizza'
|Comcast to speed up Internet for many Oregon users
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|Should gun owners carry insurance?
|VW admits system was intentionally placed to cheat
Real Time - LANE POWELL
Tweets by @lanepowell
Almost all of us can agree with this statement: America has too much gun violence in the workplace. From there, though, things get murky.
Wage gaps and workforce shortages are threatening the quality of care and supports to Oregonians with intellectual and developmental disabilities. Who's caring for those who care for our most vulnerable residents?
Engaging employees and customers along the way.
The registration fee is $30 prepay online or $35 at the door. Online registration is available at www.lanepowell.com.
Former Chief Medical Officer for Saint Alphonsus Health Alliance brings 30 years of healthcare industry expertise and innovation.
Have you reviewed and revised your vacation, sick leave and PTO polices? Determined how to best comply with Oregon's Sick Leave law? Let us help.