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- John Melvin's Profile
- Family Tree & Genealogy Tools
John Melvin
Son of Alexander Melvine and Elspet Ramsey
[sibling(s) unknown]
Husband of Hannah (Lewis) Melvin — married about in Malden, Middlesex, Massachusetts, USA [uncertain]
Husband of Margaret (Shanesberg) Melvin — married in Charlestown, MA
Father of Margaret Melvin, John Melvin, Hannah Melvin, Robert Melvin, James Melvin, Jonathan Melvin, David Melvin, Benjamin Melvin and Eleazer Melvin
Profile managers: Oscar Dayton [send private message], Jamie Swindells [send private message], John Putnam [send private message], and J. C. Adamson [send private message]
This page has been accessed 587 times.
- Birth: 1652 Leuchers Parish, Fifeshire, , Scotland
- Birth: 11 JUL 1651 Kennoway, Fife, Scotland
- Marriage: ABT 1676 Charlestown, Suffolk Co., MA
- Burial: Hill Burying Ground, Concord, MA
- Immigration: Bef. 1676, Charlestown, MA
- Stearns, Ezra S. Genealogical and Family History of the State of New Hampshire (Lewis Publishing Company, 1908) Vol. 2, Page 667
- Bond, Henry. Genealogies of the Families and Descendants of the Early Settlers of Watertown, Massachusetts (Boston: Little, Brown & Company 1855) Page: 119
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Llanfair Retirement Community is one of 11 retirement communities owned and operated by OPRS Communities, a wholly owned subsidiary of Ohio Presbyterian Retirement Services (OPRS), headquartered in Columbus. Since 1922, OPRS has defined the highest standards of quality of life for older adults. Each year, OPRS serves more than 73,000 people annually through its wholly owned subsidiaries OPRS Communities and Senior Independence.
For more information, call 513.681.4230 or visit our website at http://www.llanfairohio.org.
Read the full story at http://www.prweb.com/releases/2014/07/prweb12020754.htm.
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subset: commoncrawl


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I'm not a Street Fighter fanatic, but I've enjoyed the series over the years. So with this casual approach, I recently tried the XBLA beta of Super Street Fighter II Turbo HD Remix, available soon to buyers of Commando 3 on XBLA. The full version will be out this Summer for that system and PSN.
Frankly, I don't even remember which character I played. It doesn't help that my only choices were Ken and Ryu, who have nearly the same moves. My helpful opponent reminded me how to do some of the special attacks; I was far out of practice on the Hurricane Kick, but I could throw fireballs right away.
%Gallery-9066% Our widescreen fights looked crisp and perfectly redrawn, but I didn't spend much time taking in the visuals. Instead, I used the stick and six buttons to try to attack, defend, and counter-attack. And from my laid-back style -- I call it "shrugging panda" -- it felt good. I always thought Street Fighter captured this back-and-forth dance better than most fighting games.
The fights alternated between standard and rebalanced modes, but I didn't notice a clear difference in that moment. I'm sure that gamers who remember all of the attacks will be able to tell. In my handful of matches, I was content to just walk through the steps with an old, familiar partner. Sure, she's had some work done, but Super Street Fighter II Turbo HD Remix comes out feeling timeless.
Buy from $270
- Key specs
- Reviews • 18
- Prices
- Discussions
- Game format Optical disc, Downloadable
- Online features Multiplayer, Voice chat, Video chat, Store, Browser
- Drive capacity 250 GB
- Controller type Wired, Wireless
- Motion controls Accelerometer, Gyroscopic
- Video outputs HDMI (v1.3), RCA / composite
- Released 2012-09-25
Microsoft Xbox 360


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Young Galaxy
"Pretty Boy" (Peaking Lights remix)
Granted, it's not a completely re-envisioned outing, as it still factors in the same lovelorn vocal melodies and bubbly synth oscillations, but Peaking Lights bring a snare-clap into the equation much quicker, thus upping the light-disco qualities of the dancey cut. You can sample the extended run-through of "Pretty Boy" down below care of The Quietus.
As previously reported, Ultramarine arrives at retailers April 23 through Paper Bag Records.
Coming back soon! If our developer were more machine than man they'd already be here. Useless meatsack.
For now, please send any and all feedback to [email protected].
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Posts Tagged 'Parenthood Ratings'
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News . Feature Stories
News Highlight
September 17, 2015
By Alyssa Brown
From a young age, Shriya Garg has had a passion and talent for art. She fondly remembers her mother bringing home huge boxes of crayons and colored pencils, which Garg used to draw all over the walls. Instead of attempting to rein in those examples of her artistic exuberance, Garg's parents preserved it, and her earliest work still decorates the walls of her former family home.
As she grew older, Garg took art classes outside of her normal academic schedule, and participated in summer art school at Parsons School of Design. While her family lives in India, Garg is...continue reading
September 10, 2014
Painting chair curates exhibition exploring art, materials
Show featuring three faculty and two grads on view through Sept. 26 more
September 09, 2014
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Boulder Brewpubs & Meadery Restaurants
Perhaps you've heard about Boulder breweries, which are some of the best in the country. View our listings of breweries, brewpubs and our own meadery (a producer of fermented honey wine). Also check out the Front Range Breweries Map.
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Avery Brewing Company
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Sir William Rothenstein
1 portrait of William Rothenstein
© reserved; collection National Portrait Gallery, London
Sir William Rothenstein
by Mark Wayner (Weiner)
lithograph, 1943 or before
14 in. x 9 1/2 in. (356 mm x 242 mm) paper size
Purchased, 2006
Reference Collection
Click on the links below to find out more:
Sitterback to top
- Sir William Rothenstein (1872-1945), Artist and teacher of art. Sitter in 24 portraits, Artist associated with 220 portraits.
Artistback to top
- Mark Wayner (Weiner) (1888 or 1889-1980). Artist of 36 portraits.
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Page 1
Genetic interaction between Sox10 and Zfhx1b during enteric nervous system development
Laure Stanchina a, b, Tom Van de Putte c, d, $, Michel Goossens a, b, Danny Huylebroeck c, d, and Nadege
Bondurand a, b*
a INSERM U955, IMRB, Equipe 11, Creteil, F-94010, France,
b Universite Paris Est, Faculte de Medecine, Creteil, F-94010, France,
c Laboratory of Molecular Biology (Celgen), Center of Human Genetics, University of Leuven,
d Department of Molecular and Developmental Genetics (VIB11), Flanders Institute of Biotechnology,
B-3000 Leuven, Belgium
$ Present address: Tigenix S.A., Romeinse straat 12 box 2, B-3001 Leuven, Belgium.
* Corresponding author. Nadège Bondurand. INSERM U955, Equipe 11, Hôpital Henri Mondor, 51
Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France. Email:
firstname.lastname@example.com ; Tel: +33149812854. Fax: +33148993345
inserm-00481705, version 1 - 7 May 2010
Author manuscript, published in "Developmental Biology 2010;341(2):416-28"
DOI : 10.1016/j.ydbio.2010.02.036
Page 2
The involvement of SOX10 and ZFHX1B in Waardenburg-Hirschsprung disease (hypopigmentation,
deafness, and absence of enteric ganglia) and Mowat-Wilson syndrome (mental retardation, facial
dysmorphy and variable congenital malformations including Hirschsprung disease) respectively,
highlighted the importance of both transcription factors during enteric nervous system (ENS)
development. The expression and function of SOX10 are now well established, but those of ZFHX1B
remain elusive. Here we describe the expression profile of Zfhx1b and its genetic interactions with
Sox10 during mouse ENS development. Through phenotype analysis of Sox10;Zfhx1b double mutants,
we show that a coordinated and balanced interaction between these two genes is required for normal
ENS development. Double mutants present with more severe ENS defects due to decreased
proliferation of enteric progenitors and increased neuronal differentiation from E11.5 onwards. Thus,
joint activity between these two transcription factors is crucial for proper ENS development and our
results contribute to the understanding of the molecular basis of ENS defects observed both in mutant
mouse models and in patients carrying SOX10 and ZFHX1B mutations.
Keywords: Differentiation; Enteric nervous system; Hirschsprung; Mowat-Wilson; Neural crest;
Sox10; Transcription factor; Waardenburg; Zeb2; Zfhx1b.
inserm-00481705, version 1 - 7 May 2010
Page 3
The enteric nervous system (ENS) is the part of the peripheral nervous system that controls the
peristaltic and secretory activity of the gut wall (Gershon, 1994). It is composed of a large number of
neurons and glial cells, which are organized into interconnected ganglia distributed throughout the
length of the gut (Burns and Thapar, 2006; Furness, 2006; Hao and Young, 2009; Heanue and
Pachnis, 2007). During embryogenesis, most of the ENS is derived from the vagal neural crest cells
(Le Douarin and Kalcheim, 1999). A small portion also derives from the sacral region (Burns and
Douarin, 1998). After delaminating from the neural tube, vagal neural crest cells enter the foregut at
day E9.5 in mice and, migrating in a rostrocaudal direction, colonize the entire length of the gut by
E15. Altered proliferation, survival, migration or differentiation of ENCC (Enteric Neural Crest Cells)
result in an absence of enteric ganglia (aganglionosis), usually affecting the colon, and leading to
severe constipation or intestinal obstruction (Hirschsprung disease, HSCR) (for review see (Amiel et
al., 2008; Heanue and Pachnis, 2007). Studies performed so far led to the identification of critical
players in ENS development, including the Receptor Tyrosine Kinase RET, its ligands GDNF and
NTN, the G-coupled receptor EDNRB and its ligand endothelin-3, the BMP signaling pathway, KBP,
β1 integrin and L1-CAM adhesion molecules, and the transcription factors PHOX2B, MASH1,
HAND2, ZFHX1B and SOX10 (for review see (Amiel et al., 2008; Burns and Thapar, 2006;
Burzynski et al., 2009; Hao and Young, 2009; Heanue and Pachnis, 2007).
SOX10 is a member of the high-mobility group-domain SOX family of transcription factors (for
review, see (Bowles et al., 2000; Kelsh, 2006; Mollaaghababa and Pavan, 2003; Wegner, 1999;
Wegner, 2005; Wegner, 2009; Wilson and Koopman, 2002). In 1998, cloning and involvement of this
gene in a spontaneous mouse model of Waardenburg-Hirschsprung disease (the Dom mouse
presenting with hypopigmentation, deafness, and absence of enteric ganglia) showed its crucial role
for proper neural crest cells development, and ENS and melanocytes in particular (Herbarth et al.,
1998; Southard-Smith et al., 1998). Invalidation of this gene by targeted gene deletion confirmed these
observations (Britsch et al., 2001). Indeed, at the heterozygous state, both mouse mutants exhibit
pigmentation defects and absence of enteric ganglia from a variable length of the colon. Homozygous
mutant mice on the other hand have severe deficits in several neural crest derivatives, including
complete lack of ENS (Britsch et al., 2001; Herbarth et al., 1998; Kapur, 1999; Southard-Smith et al.,
During mouse development, Sox10 is first expressed in neural crest cells, including cells of vagal
origin, as they delaminate from the neural tube. At this stage, SOX10 protein appears to be required
for the survival and the maintenance of these cells prior to lineage segregation (Honore et al., 2003;
Kapur, 1999; Kim et al., 2003). When they enter the foregut, all ENCC express Sox10, which is
considered a marker of ENS progenitors (for review, see (Heanue and Pachnis, 2007)). In partial
inserm-00481705, version 1 - 7 May 2010
Page 4
absence of Sox10, mice possess a smaller pool of ENS progenitors, strongly suggesting a role for this
HMG-type transcription factor in maintaining progenitor state (Paratore et al., 2002). Later, Sox10 is
expressed in glial cells but switched off in neurons (Bondurand et al., 2003; Young et al., 2003), and it
is proposed to function in cell fate specification and glial cell differentiation (for review, see (Heanue
and Pachnis, 2007)). Extinction of this gene seems to be a prerequisite for complete neuronal
differentiation. Consistent with these observations, constitutive expression of Sox10 inhibits overt
neuronal differentiation in cultured ENCC (Bondurand et al., 2006).
An increasing number of molecular and developmental studies revealed that interactions between
SOX10 and other pathways are crucial for proper ENS development. Genome-wide association studies
performed in mice as well as phenotypic analysis of mouse double mutants revealed interactions
between Sox10 and loci located on chromosomes 3, 5, 8, 11 and 14 as well as with Sox8, Ret, and
endothelin-3/Ednrb (Cantrell et al., 2004; Lang et al., 2000; Maka et al., 2005; Owens et al., 2005;
Stanchina et al., 2006; Zhu et al., 2004). It now seems crucial to expand this gene network and identify
which other factors could interact with Sox10, thus controlling multi-lineage ENS progenitor
maintenance and enteric differentiation.
ZFHX1B (Zinc Finger HomeoboX 1b; also known as ZEB2, Zinc finger E-box Binding homeobox 2
or SIP1, Smad Interacting Protein 1) belongs to the Zfhx1 family proteins in vertebrates. Originally
described as transcriptional repressors, these transcription factors are characterized by a
homeodomain- like domain and two separated clusters of multiple zinc fingers (Postigo and Dean,
2000; van Grunsven et al., 2001; Verschueren et al., 1999). ZFHX1B was identified in a yeast two-
hybrid screen as a protein binding to the MH2 domain of Smad1 (Verschueren et al., 1999) and is
therefore a candidate component of the signal transduction pathways triggered by the Smad effector
proteins of the TGF-β/BMP family (Eisaki et al., 2000; Postigo, 2003; van Grunsven et al., 2001).
Numerous studies have shown that it is involved in neural specification where it has been proposed to
transcriptionally inhibit BMP production (Eisaki et al., 2000; Nitta et al., 2007; Nitta et al., 2004; Van
de Putte et al., 2003; van Grunsven et al., 2007). Recent studies in Xenopus have shown that XSIP1
binds directly to the proximal promoter of Bmp4 and represses expression of this gene (van Grunsven
et al., 2007). ZFHX1B has also been shown to play an important role in epithelial-mesenchymal
transition (EMT) by repressing several adhesion molecules including E-cadherin (Comijn et al., 2001;
van Grunsven et al., 2003; Vandewalle et al., 2005).
The role of ZFHX1B in ENS development was first highlighted by its involvement in Mowat-Wilson
syndrome, a dysmorphic and severe mental retardation syndrome with occurrence of Hirschsprung
disease or constipation (Cacheux et al., 2001; Dastot-Le Moal et al., 2007; Garavelli et al., 2009;
Wakamatsu et al., 2001; Zweier et al., 2005). Generation of Sip1/Zfhx1b/Zeb2 knock-out mice
revealed that it is essential for specification of sufficient numbers of vagal neural crest cells (Higashi
inserm-00481705, version 1 - 7 May 2010
Page 5
et al., 2002; Van de Putte et al., 2003). Heterozygous animals present with no apparent gross
morphological defects except an absence of corpus callosum, but homozygotes die at E9.5 and present
with cardiovascular dysfunction, an aberrant neural plate, failure of the neural tube to close, and
shortened somites. More importantly, Zfhx1b homozygous embryos show a delay in cranial neural
crest migration and the near-absence of vagal neural crest formation (Van de Putte et al., 2003).
Recently, a conditional knock-out has been generated in which Zfhx1b was specifically removed in
neural crest cells using a Wnt1-Cre crossing strategy. Homozygous mice present with specific
abnormalities in craniofacial, heart, melanocytes and peripheral nervous system development as well
as severe intestinal aganglionosis (Van de Putte et al., 2007). In human, mice and zebrafish,
preliminary expression studies revealed the presence of Zfhx1b within vagal enteric precursor cells
upon gut invasion. Later during development, the whole ENS is heavily expressing this factor (Bassez
et al., 2004; Delalande et al., 2008; Espinosa-Parrilla et al., 2002; Van de Putte et al., 2007). However,
the spatio-temporal expression profile and function of ZFHX1B during ENS development and
differentiation as well as its interaction with other ENS factors remain poorly studied.
Here we analyzed the expression of Zfhx1b and explored the possibility of genetic interactions
between this gene and Sox10 during ENS development. To this end, we crossed the conventional
Zfhx1b mutant with the Sox10 knock-out mouse, compared the enteric phenotype of single and double
heterozygous animals, and investigated the cellular origin of the observed ENS defects.
Materials and methods
Animals, pups, embryos collection and genotyping
The generation of Sox10LacZ and Zfhx1b∆ex7 animals have been described previously (Britsch et al.,
2001; Higashi et al., 2002; Van de Putte et al., 2003). Sox10LacZ mice were backcrossed on C3HeB/FeJ
for at least 4 generations before use. Zfhx1b∆ex7 were generated and maintained on CD1 background.
Alternatively, Zfhx1b∆ex7 were crossed on C3HeB/FeJ background. Similar results were obtained
whatever the genetic background used. The genotype of mice and embryos was determined by PCR
analysis of genomic DNA extracted from a tail tip fragment or yolk sac, respectively using PCR
primers previously described (Britsch et al., 2001; Van de Putte et al., 2007), except for Zfhx1b-
intron6R which was modified as follows: 5'-ATCAGCAGCCTCCTATTTAAACAGAGTGTC-3'.
Zfhx1b∆/+ mice were crossed with Sox10LacZ/+ to generate embryos and pups. Embryos from E9.5 to
E15.5 were obtained from staged pregnancies. The day of vaginal plug was considered to be E0.5.
Dissected guts or embryos were fixed one to two hours in 4% paraformaldehyde at 4°C. After fixation,
8 m frozen sections of embryos of different genotypes were generated. Dissected guts or sections
inserm-00481705, version 1 - 7 May 2010


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USGS Deploys Crews in Advance of Hurricane Joaquin in Virginia ...read more
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USGS science will inform key strategies to restore the Bay watershed ...read more
USGS leads STAC report on Land Management Effects on Water-Quality Status and Trends ...read more
New USGS report: Excess manure and fertilizer are worsening water-quality conditions on Eastern Shore of Chesapeake ...read more
To read previous USGS features about the Chesapeake Bay visit...
Accounting for groundwater in stream fish thermal habitat responses to climate change—Journal Article
A bootstrap method for estimating uncertainty of water quality trends—Journal Article
Understanding Nutrients in the Chesapeake Bay Watershed and Implications for Management and Restoration—The Eastern Shore—Circular 1406 (Revised 5-6-15, ver. 1.1)
Sediment Transport and Capacity Change in Three Reservoirs, Lower Susquehanna River Basin, Pennsylvania and Maryland, 1900–2012—Open-File Report 2014-1235
Rising air and stream-water temperatures in Chesapeake Bay region—Article — Feature.
For more visit the Bibliography of USGS Chesapeake Bay Publications page.


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The Journal Sentinel sports staff brings fans the latest news and inside information on the Brewers
Brewers announce updated schedule
The Brewers announced Monday the complete schedule for the 2012 season, including all home and road game times.
Several home games have new start times, revised from what was listed in the original schedule announcement on Sept. 14.
The team will open the 2012 campaign at home against the St. Louis Cardinals on Friday, April 6 at 3:10 p.m. Opening Day marks the first of a three-game set versus the NL Central rival and is followed by a trip to Chicago to play the Cubs for four games (April 9 – 12) and to Atlanta for three more with the Braves (April 13 – 15).
Included in opening weekend is a new game time for the Saturday, April 7 game vs. St. Louis. That game will now start at 3:05 p.m. and will be broadcast nationally on FOX. Additional national FOX games, with corresponding changes to previously-announced start times, include Saturday, April 28 at St. Louis (12:05 p.m.); Saturday, May 12 vs. Chicago-NL (12:05 p.m.); Saturday, June 23 at Chicago-AL (6:15 p.m.) and Saturday, June 30 vs. Arizona (6:15 p.m.).
Several additional home games feature new start times. They include Saturday, May 19 vs. Minnesota (3:10 p.m.); Saturday, June 9 vs. San Diego (3:10 p.m.); Saturday, Aug. 18 vs. Philadelphia (6:10 p.m.); Monday, Sept. 10 vs. Atlanta (7:10 p.m.) and Wednesday, Sept. 12 vs. Atlanta (7:10 p.m.).
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Health Care Technology
Company Overview of ShiftWise, Inc.
Executive Profile
Jason Drucker
President, ShiftWise, Inc.
|Total Calculated Compensation
|This person is connected to 0 Board Members in 0 different organizations across 1 different industries.
Mr. Jason Drucker serves as President at ShiftWise, Inc and served as its Senior Vice President of Sales & Operations and Chief Operating Officer. Mr. Drucker served as Senior Vice President of Marketing & Sales at ShiftWise, Inc. and was responsible for all communication activities as well as continuing to grow industry leading customer base. Mr. Drucker started his career in I.T. staffing with Vedior NV. He transferred to the managed service division of Vedior, Global ...
Corporate Headquarters
1800 SW 1st AvenuePhone: 503-548-2030
Portland, Oregon 97201
United States
Fax: 503-548-1299
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2/25/2015 Prof. Rebecca Klatzkin and Student Researchers Shed Light on Binge EatingCo-authors are Sierra Gaffney '15, Kathryn Cyrus '15 and Elizabeth Bigus '14. »
2/24/2015 Prof. Michael LaRosa Publishes Latest Immigration Reform Commentary in TennesseanThe article was written with Rhodes alumnus Bryce W. Ashby '00. »
2/24/2015 Rhodes Alumnus David LaFevor '03 to Make Presentation as Part of March Events Focusing on United States-Latin American RelationsHis presentation includes photographs recently shot in Cuba. »
2/23/2015 Mike Curb Institute to Present "The Great Flood" Film by Bill Morrison with Music by Bill FrisellThe event also features musicians Ron Miles, Tony Sherr, and Kenny Wollesen. »
2/20/2015 Women's Swimming and Diving Team Captures SAA Championship TitleAlso, Virginia Carr nabbed the SAA Newcomer of the Year, and head coach Charlie Boehme was named the SAA Women′s Coach of the Year. »
2/20/2015 Ramen Noodle Ideas by Emily Clark '15 Make USA TodayHer article includes a video for Ramen Remix. »
2/18/2015 Prof. Jackson-Hayes Publishes Washington Post Article on Value of STEM Majors with Liberal Arts TrainingShe is an associate professor of chemistry at Rhodes. »
2/18/2015 Prof. Charles McKinney Publishes New Civil Rights Article on History Now History Now is an online web portal dedicated to the teaching of American History. »
2/18/2015 Prof. Michael Nelson Helps to Develop New Site Revealing Insiders' Views of 2004 Presidential ElectionHe served as editor and the primary interviewer and researcher. »
2/11/2015 Mid-South Model UN Conference to Take Place at RhodesAbout 300 high school students will be on campus for the event Feb. 13-15. »
2/10/2015 Rhodes College President to Serve on Tennessee State Board of Education Dr. William E. Troutt has been appointed by Gov. Bill Haslam to the nine-member board. »
2/9/2015 Rhodes Makes Princeton Review's New "Colleges That Pay You Back" ListThe schools also were ranked in certain individual categories, and Rhodes is No. 7 in the "Top 25 Schools for Internship Opportunities." »


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Hyatt Place Fort Lauderdale Airport-South
- Budget Minded
The Gallery Cafe is open 24-hours a day and offers a wide selection of tasty meals, refreshing beverages, and popular snacks.
The Hyatt Place Fort Lauderdale Airport-South is located just south of the Fort Lauderdale/Hollywood International Airport, the Port Everglades Cruise Port and the Broward County Convention Center, each just an exit away, off of I-95. The hotel is situated minutes from breathtaking beaches, pristine golf courses and a large variety of shops and restaurants on the nearby Las Olas Boulevard and Hollywood Boulevard. The LandShark Stadium (Dolphins/Marlins) and the Hard Rock Café and Casino are also just a short drive away. The Hyatt Place Ft. Lauderdale Airport-South offers complimentary shuttle service to and from the Fort Lauderdale/Hollywood International Airport.During your stay at our Fort Lauderdale Airport hotel, you can enjoy specialty Starbucks® coffee drinks and friendly conversation at the intimate Bakery Cafe'. A Host will happily assist you with orders from the 24-hour Guest Kitchen, which offers cafe'-quality, made-to-order meals and snacks along with a complimentary continental breakfast daily. This Fort Lauderdale Airport hotel features spacious guestrooms each with the Hyatt Grand Bed™ and a 42" flat panel HDTV Complimentary Wi-Fi available throughout the hotel Complimentary continental breakfast daily 24/7 Guest Kitchen serves made-to-order snacks and entrees Intimate Bakery Café serves Starbucks® specialty coffees, premium beers and wines Grab 'n Go case offers muffins, salads, sandwiches and bottled beverages e-room with complimentary computers and a printer at this Fort Lauderdale Airport hotel Complimentary parking if less than seven nights
In Florida, there's fun in every direction. So much so, you might need to stay a little longer to experience it all. Check out this amazing deal to boost your vacation and save some money while you're at it.