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Gross cystic disease fluid protein 15 (GCDFP-15), which is regulated by the androgen receptor (AR), is a diagnostic marker for mammary differentiation in histopathology. We determined the expression of GCDFP-15 in breast cancer subtypes, its potential prognostic and predictive value, as well as its relationship to AR expression.
602 pre-therapeutic breast cancer core biopsies from the phase III randomized neoadjuvant GeparTrio trial (NCT00544765) were investigated for GCDFP-15 expression by immunohistochemistry. Expression data were correlated with disease-free (DFS) and overall survival (OS) time as well as pathological complete response (pCR) to neoadjuvant chemotherapy.
239 tumors (39.7%) were GCDFP-15 positive. GCDFP-15 expression was positively linked to hormone receptor (HR) and HER2 positive tumor type, while most triple negative carcinomas were negative (p < 0.0001). GCDFP-15 was also strongly correlated to AR expression (p 0.001), and to the so-called molecular apocrine subtype (HR-/AR+, p < 0.0001). Higher rates of GCDFP-15 positivity were seen in tumors of lower grade (<0.0001) and negative nodal status (p = 0.008). GCDFP-15 positive tumors tended to have a more favourable prognosis than GCDFP-15 negative tumors (DFS (p = 0.052) and OS (p = 0.044)), which was not independent from other factors in multivariate analysis. GCDFP-15 expression was not linked to pCR. Histological apocrine differentiation was frequent in molecular apocrine carcinomas (60.7%), and was associated with GCDFP-15 within this group (p = 0.039).
GCDFP-15 expression is higher in tumors with favorable prognostic features. GCDFP-15 expression is further a frequent feature of AR positive tumors and the molecular apocrine subtype. It might have reduced sensitivity as a diagnostic marker for mammary differentiation in triple negative tumors as compared to HR or HER2 positive tumor types.
Keywords:GCDFP-15; Breast cancer; Neoadjuvant chemotherapy; Apocrine; CUP
Gross cystic disease fluid protein 15 (GCDFP-15, syn. prolactin-inducible protein, PIP) is a 15 kDa protein that was originally detected in the cystic fluid from cystic mastopathy [1]. It is not expressed in normal ductal or lobular epithelium but in apocrine metaplasia of the breast [2]. Apart from breast cancer, only very few tumors, such as prostate cancer and carcinomas of the skin appendages express GCDFP-15 [3]. It is therefore highly specific for mammary differentiation in females, and is frequently used as an immunohistochemical marker for the evaluation of a potential mammary origin of metastatic carcinoma of unknown primary site. The expression of GCDFP-15 is regulated by the androgen receptor (AR) [4], however, little is known about its function. A recent study on gene expression profiles in androgen-stimulated, GDCFP-15 expressing versus GCDFP-15 non-expressing breast cancer cell lines, reported an up-regulation of pro-apoptotic and anti-proliferative genes along with GCDFP-15 [5]. In carcinomas of the breast, GCDFP-15 is also used as a marker for apocrine differentiation [2,6-9]. Apocrine breast carcinoma is a rare subtype of invasive ductal carcinoma, which is primarily defined by morphological features such as abundant eosinophilic and granular cytoplasm, and shows frequent expression of the androgen receptor (AR) [10]. Some years ago a so-called molecular apocrine subset of breast carcinoma has been defined by gene expression analysis, and was characterized by active AR and weak or absent estrogen receptor (ER) signalling [11]. In this study, all tumors that were assigned to the molecular apocrine group had strong morphological features of apocrine differentiation. The existence of the molecular apocrine subtype has since then been reproduced [12,13]. However, its clinical impact is conflictive to date.
We used a large and well-characterized cohort of breast cancer patients who underwent anthracycline/taxane-based neoadjuvant chemotherapy (NACT) in the phase III randomized GeparTrio trial (NCT00544765) to investigate the distribution of GCDFP-15 expression in biological subtypes of breast cancer, its potential prognostic and predictive value, as well as its relationship to AR expression. GCDFP-15 expression and biological tumor types were determined by immunohistochemistry in pre-therapeutic breast cancer core biopsies.
Study Population
Samples from the prospective neoadjuvant phase III GeparTrio study (NCT00544765) and the GeparTrio pilot study performed by the German Breast Group (GBG), Neu-Isenburg, Germany were used. Patients were treated with anthracycline/taxane-based NACT. The details of study setup and treatments have been published before [14-17]. HER2 positive patients had not received trastuzumab in GeparTrio as this was not the standard of care during the study period. Baseline clinico-pathological data as well as data on hormone receptor (HR) status were extracted from the study databases. Centrally evaluated data on HER2 expression (based on immunohistochemistry and silver-enhanced in situ hybridization according to ASCO/CAP guidelines [18] were used, as HER2 determination was not yet fully established in all pathologic laboratories at the time the study was conducted. Grading and histology were also centrally determined; local data on HR expression were used and substituted with central data if missing (central evaluation: Institute of Pathology, Charité Berlin). Consistent with the current practise when the trial was performed, HR positivity was defined as estrogen (ER) or progesterone receptor (PR) expression in more than 10% of tumor cells. We also exploratorily applied the cutoff of 1% currently recommended by ASCO/CAP [19]; use of this definition of HR positivity yielded quite similar results (see results section). Data on AR expression had been obtained from 545 cases in a previous study [20]. In brief, AR staining intensity as well as percentage of stained cells was multiplied to an immunoreactivity score (IRS), ranging from 0 (negative in all cells) to 12 (strongly expressed in more than 80% of cells). Cases with an IRS from 0–3 were scored as AR negative, opposed to cases with an IRS of 4–12 (=AR positive). Definition of pathological complete response (pCR) was complete absence of invasive tumour cells in the breast and lymph nodes as assessed at the time of surgery by the local pathologist (ypT0/Tis; ypN0). Data on disease-free survival (DSF) and overall survival (OS) were available for 570 patients, with mean DFS of 3.08 years and mean OS of 3.42 years. The baseline demographic and clinical characteristics of the patients with tissue available for this translational research project are shown in Table 1. The protocol was reviewed and approved by all responsible ethics committees (Additional file 1: Table S1). All patients provided written informed consent for anonymized subsequent translational research.
Table 1. Association of GCDFP-15 expression with baseline clinico-pathological parameters
Additional file 1. Ethics committees that approved the GeparTrio study.
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Construction of a tissue micro array (TMA) of pre-therapeutic core biopsies has been explained previously [20]. Immunohistochemistry was performed on a Ventana BenchMark XT instrument (Ventana Medical Systems Inc., Tucson, AZ, USA) after pre-treatment with protease using a mouse monoclonal antibody directed against human GCDFP-15 (clone D6, dilution 1:400, Covance, Princeton, NJ, USA). For visualization, the iView DAB detection kit (Ventana Medical Systems Inc.) was used. Stained slides were digitized and evaluated on the computer monitor with support of the TMA Evaluator software (VMScope GmbH, Berlin, Germany) by a board certified pathologist (S. D.-E.). Both staining intensity and the percentage of stained tumor cells were evaluated and combined to an IRS (see previous chapter).
Statistical evaluation
Statistical analysis was performed using SPSS Statistics 19 (IBM Corporation, Somers, NY, USA). In logistic regression analyses, significance of the correlation with pCR was assessed by the Wald test. Survival analyses were performed with the Kaplan-Meier method and univariate log-rank test and with Cox regression analysis for multivariate tests. The association between GCDFP-15 expression and clinico-pathological factors, biological tumor types, and AR expression was analysed by Fisher's exact test or Pearson's chi square test, as indicated. All tests were two-sided, and p-values <0.05 were considered as significant.
GCDFP-15 expression pattern in human breast carcinomas
844 TMA spots were evaluated (one for each individual tumor), whereas 203 spots contained no tumor cells (24.1%), and 39 spots contained no tissue (4.6%), resulting in 602 informative cases (Figure 1). Consistent with previous reports [21,22], we found GCDPF-15 restricted to the cytoplasm of tumor cells. Positive tumors mostly displayed a weak to moderate stain in variable fractions of cells, and a patchy or mosaic-like pattern could be frequently found (Figure 2A, B). Sparse tumors showed diffuse staining (Figure 2C). In the majority of samples however, GCDFP-15 expression was totally absent (n = 363 (60.3%, Figure 2D)). We therefore decided to score each apparent staining as positive and opposed it to totally lacking staining. No GCDFP-15 staining was seen in non-epithelial cells such as stromal or inflammatory cells.
Figure 1. Consort diagram.
Figure 2. Immunohistochemical expression pattern of GCDFP-15 in breast cancer. A Tumor cells of an invasive lobular carcinoma, arranged in indian file pattern and exhibiting moderate cytoplasmic staining for GDCFP-15 B Solid carcinoma nests with patchy, mosaic-like pattern of GCDFP-15 expression C Diffuse GCDFP-15 expression in a poorly differentiated ductal carcinoma D Distribution of GCDFP-15 immunoreactivity scores (IRS) in the study group. The majority of cases did not display any staining (IRS = 0); in the remaining carcinomas, IRS values were equally distributed; the cut-off was set between IRS = 0 and IRS = 2.
Association with biological tumor types and clinico-pathological factors
GCDFP-15 expression was significantly enriched in tumors with certain biological characteristics. There was a modest increase of GDCFP-15 expression in HR and in HER2 positive tumors (Table 1). GCDFP-15 positivity rate was 43.1% in HR positive tumors and 33.7% in HR negative tumors (p = 0.034), and 48.3% HER2 positive carcinomas expressed GCDFP-15 as opposed to 37.4% HER2 negative tumors (p = 0.035). Consequently, GCDFP-15 was also differentially distributed among biological tumor types, as defined by HR and HER2 status: frequency of positive tumors was significantly higher in luminal subtypes (HR+/HER2-: 42.4%, HR+/HER2: 45.6%) as well in HER2 positive tumors (HR-/HER2+: 55.8%) as opposed to in triple negative breast carcinomas (TNBC, HR-/HER2-: 26.2%, p = 0.001, Table 1). Consistent with GCDFP-15 being a downstream target gene of AR [4], there was a strong association between GCDFP-15 and AR expression. 51.5% of AR positive tumors were also positive for GCDFP-15, whereas only 24% of AR negative carcinomas showed GCDFP-15 staining (p < 0.0001). As AR is a frequent feature of apocrine tumor differentiation and GCDFP-15 has also been proposed as a marker for apocrine differentiation, we tested GCDFP-15 expression for an association with the so-called molecular apocrine subtype (HR-/AR+), as described by Farmer et al. [11]. Tumor types according to Farmer were grouped as follows: HR + (AR+/-), n = 365), HR-/AR + (n = 56), and HR-/AR- (n = 101). HER2 positivity was more frequent in molecular apocrine carcinomas (42.9% as opposed to 17.1% in HR + (AR+/-) and 15.8% in HR-/AR-, p < 0.0001). There was a significant association between GCDFP-15 and molecular apocrine subtype, with 67.9% GCDFP-15 positive cases in this group (p < 0.0001). 41.6% of HR + (AR+/-) tumors were also positive for GCDFP-15, while the rate of GCDFP-15 positive cases in the subgroup that was completely negative for steroid hormone receptors (HR-/AR-) with 18.8% was lower than the one in triple negative tumors (HR-/HER2-, 26.2%, Table 1). GCDFP-15 was further associated with certain favorable tumor features, such as lower tumor grade (p < 0.0001), and negative nodal status (p = 0.008, Table 1). Using the currently by ASCO/CAP guidelines [19] recommended cutoff for ER/PR evaluation (<1% stained tumor cells = negative, > = 1% stained tumor cells = positive) we obtained similar results: HR positivity rate in the total study group was 79.5%, GCDFP-15 expression still was associated with HR positivity (p = 0.046) and with molecular apocrine tumor type (p < 0.0001), although the rate of molecular apocrine tumors was now decreased to 6.5%.
Morphological features of molecular apocrine carcinomas
We further wondered whether the molecular apocrine subtype was showed a distinct morphology and re-evaluated hematoxylin/eosin-stained large sections of pre-therapeutic core biopsies according to apocrine differentiation. Criteria were based on Vranic et al. (2013) [6] and included tumors with large nuclei and characteristic abundant eosinophilic granular or foamy cytoplasm (type A, type B cells). Indeed, molecular apocrine carcinomas were quite frequently of apocrine phenotype (34/56, 60.7%, Figure 3A). Two carcinomas of pleomorphic lobular subtype, a poorly differentiated subgroup of lobular-invasive carcinoma reported to cluster with molecular apocrine tumors by gene expression analysis [23], were among them (Figure 3B). Histologically apocrine carcinomas with HR-/AR + profile were GCDFP-15 positive in most cases (27/34, 71.1%, p = 0.039; Figure 3A, B).
Figure 3. Morphology of molecular apocrine carcinomas. A Apocrine carcinoma with abundant eosinophilic granular cytoplasm exhibiting diffuse GCDFP-15 expression (insert) B Pleomorphic lobular carcinoma with dyscohesive growth of large cells with highly atypical nuclei and eosinophilic granular cytoplasm, strong diffuse GCDFP-15 expression is seen by immunohistochemistry (insert).
Prognostic impact of GCDFP-15 expression
GCDFP-15 expression was also studied for a potential prognostic impact. GCDFP-15 positive tumors tended to have a more favourable prognosis than GCDFP-15 negative tumors (DFS (p = 0.052) and OS (p = 0.044)) in the study group (Figure 4A, B, Table 2). Explorative multivariate Cox regression analysis including HR and HER2 expression, age, nodal stage, and grading showed that GCDFP-15 expression was not an independent prognostic factor for OS (HR = 0.67, 95% CI = 0.37-1.20, p = 0.179, not shown). Similarly, GCDFP-15 was not a significant prognostic marker for OS or DFS within the biological tumor types (HR+/HER-, HR+/HER2+, HR-/HER2+, HR-/HER2-) or in Farmer tumor types (HR + (AR+/-), HR-/AR+, HR-/AR-; p < 0.05 for each test, not shown). Farmer tumor types by themselves were also prognostic for DSF and OS (log rank p = 0.024 for each), however a survival difference was seen only between HR- and HR + tumors, and was irrespective of an additional AR expression (data not shown). The following established prognostic makers for DFS and/or OS were significant in univariate analysis in the GeparTrio cohort as well: HR expression, biological tumor types, age, tumor grade, cT, and cN (Table 2).
Figure 4. Survival analysis A, B DFS and OS in dependence of GCDFP-15 expression in the study group.
Table 2. Univariate survival analysis
Predictive value of GCDFP-15 expression
We further evaluated if GCDFP-15 expression might have predictive value for response to NACT and performed logistic regression analysis. In the total study group, there was a non-significant trend towards a reduced probability of pCR in GCDFP-15 positive tumors (pCR rate 21.2% vs 15.9%, OR = 0.70, 95% CI = 0.46-1.08, p = 0.106, Table 3). GCDFP15 expression was not indicative of response to NACT within biological tumor types or Farmer tumor types (p < 0.05 for each test, not shown). Farmer tumor types were significantly predictive for pCR, however similarly to the survival analysis, only the HR status was relevant for the predictive effect, and there was no difference between molecular apocrine (HR-/AR+) and HR-/AR- tumors: odds ratio (OR) of HR-/AR + 4.1 (95% CI 2.1-7.7), pCR rate 33.9%; OR of HR-/AR- 4.2 (95% CI 2.5-7.1), pCR rate 34.7%, as compared to HR+, respectively (p < 0.0001, pCR rate 11.2%). Already known predictive factors were also significant in our cohort: age, histological type, grade, HR expression, HER2 expression, and biological tumor types (Table 3).
Table 3. Univariate logistic regression: association with pCR
We investigated the expression of GCDFP-15 in a large and well-characterized clinical trial cohort of breast carcinomas treated with NACT with a special emphasis on its distribution in breast cancer subtypes and its prognostic impact. We found that GCDFP-15 was increased in HR positive as well as in HER2 positive subtypes as compared to TNBC (HR-/HER2-). GCDFP-15 expression was not predictive for response to NACT. Although GCDFP-15 was a favorable prognostic factor for DFS and OS in univariate analysis, this impact was not independent from other factors and not evident within breast cancers subtypes. GCDFP-15 was furthermore strongly associated with AR and therefore enriched in the so-called molecular apocrine breast cancer subtype.
Although widely used as a diagnostic marker for breast carcinoma in pathology, the prognostic value of GCDFP-15 has not been systematically evaluated to date. Pagani (1994), in a small case series of 33 breast cancers found evidence of a longer relapse-free survival in patients with tumors positive for GCDFP15 gene expression [24]. Fritzsche et al. (2007) reported GCDFP-15 as a positive prognostic factor in a cohort of 165 carcinomas [25]. However, in this study the prognostic impact of GCDFP-15 expression was not investigated for each biological tumor type separately. Due to the very different molecular biology of those breast cancer subtypes, biomarkers may have quite varying prognostic implication within the subtypes. We show here that the prognostic impact of GCDFP-15 is most likely a bystander effect of its association with other factors, such as HR expression, nodal stage, and tumor grade. Our study thereby confirms previous findings of an association between GCDFP-15 expression and features of good-prognosis tumors [7,22,26], and it might be speculated that GCDFP-15 parallels the expression of its regulatory factor AR, which is also linked to favorable prognostic clinico-pathological features, as we showed previously [20]. We further found that GCDFP-15 is differentially expressed in breast cancer subtypes and is enriched in luminal and HER2 positive carcinomas, while being relatively sparse in TNBC. Similarly, Huo et al. (2013) reported a rather low percentage of GCDFP-15 positives in primary (14%) and metastatic TNBC (21%) [19]. Lewis et al. (2011) found even higher rates of GCDFP-15 expression than us in luminal (65-71%) and in HER2 positive carcinomas (64%), and found only one out 33 TNBC (basal-like and unclassified triple negative tumors) to be positive for GCDFP-15, however, their cohort being relatively small, might have underestimated the frequency of GCDFP-15 positivity in TNBC [22]. Taken together, these data warrant care if GCDFP-15 is used as a diagnostic marker for mammary differentiation of metastases of a cancer of unknown primary (CUP) because a significant proportion of breast cancers, particularly TNBC might be negative. An extended panel of immunohistochemical markers for mammary differentiation should be used to increase sensitivity. We show an enrichment of GCDFP15 expression in HER2 positive tumors and a strong association with AR expression, and are therefore in line with previous reports [7,22,27]. Not surprisingly, we further found GCDFP-15 to be elevated in the so-called molecular apocrine carcinomas that are defined by AR expression in the absence of HR expression [11]. In our study histological apocrine differentiation was found in 60.7% of molecular apocrine carcinomas; additionally, GCDFP-15 within the molecular apocrine subgroup was associated with histological signs of apocrine differentiation, which suggests that ER/PR, AR, and GCDFP-15 expression are helpful markers to confirm apocrine differentiation in morphologically conspicuous cases. On the other hand, 39.3% of HR-/AR + carcinomas did not show apocrine morphology in our cohort, which indicates that molecularly and morphologically defined apocrine groups overlap only partly. The clinical significance of the molecular apocrine subtype is not clear to date and remains to be determined as proposed by the current WHO Classification of Tumors of the Breast [28] (2012), similarly conflictive data exist regarding the prognostic impact of histologically defined apocrine subtype (reviewed by Vranic et al. [6]). Our study does not point to a particular prognosis or therapy response of HR-/AR + carcinomas, as pCR rate and survival times were quite similar to those in HR- tumors without AR expression. Interestingly, HER2 expression seems to interact with AR in HR negative tumors in prognostic terms, as in our previous study in the same cohort, AR positivity was a positive prognostic factor only in the molecular subgroup of triple negative breast cancer (as defined by ER/PR/HER2 negativity).
A limitation of our study is the reduced sample size in the HER2 positive tumor types (HR+/HER2+: n = 68, HR-/HER2+: n = 43), which might hamper the detection of a differential expression of GCDFP-15 or a prognostic impact of GCDFP-15 expression within those tumor types. Furthermore, relatively short follow-up times indicate that survival analysis should be interpreted cautiously (the GeparTrio study not being powered for survival as a primary end point). An additional limitation might be that we used a TMA constructed out of core biopsies, which in some cases contained only few tumor cells and which together with the focal expression pattern of GCDFP-15 might result in a reduced sensitivity for detection of GCDFP-15 expression in some tumors. However, the rate of GCDFP-15 expression in our study group (39.7%) was in the range reported in the literature [21,26]. Only 602 out of 2.357 patients in the original GeparTrio studies could be included for this project; however this is still the largest study on GCDFP-15 expression to date.
GCDFP-15 is expressed in all major biological breast cancer subtypes, and may be particularly useful as a diagnostic marker for mammary differentiation in HR and HER2 positive tumors, while there is reduced sensitivity in the triple negative subset. Due to its strong link to AR expression it may also be a marker for the so-called molecular apocrine subtype. GCDFP-15 is linked to clinico-pathological factors that indicate a better patient outcome, but is by itself no independent prognostic factor and is not predictive of response to anthracycline/taxane-based NACT.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
Conception and design: SDE, SL, CD. Provision of study materials or patients: GvM, BA, BH, GK, TR, KK, BF, KB, RM, HE, CT, SDE, CD, BP, MD, SL. Collection and assembly of data: SDE, GvM, CD, MKM, SL. Data analysis and interpretation: SDE, CD, BP, SL, Manuscript writing and final approval of manuscript: SDE, GvM, CD, BA, BH, MKM, GK, TR, BP, KK, BF, KB, RM, MD, HE, CT, SL.
We thank Mrs. Petra Wachs for her excellent technical assistance. This project was supported by institutional funding.
Haagensen DE Jr, Mazoujian G, Holder WD Jr, Kister SJ, Wells SA Jr: Evaluation of a breast cyst fluid protein detectable in the plasma of breast carcinoma patients.
Mazoujian G, Pinkus GS, Davis S, Haagensen DE Jr: Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features.
Wick MR, Lillemoe TJ, Copland GT, Swanson PE, Manivel JC, Kiang DT: Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin.
Loos S, Schulz KD, Hackenberg R: Regulation of GCDFP-15 expression in human mammary cancer cells.
Debily MA, Marhomy SE, Boulanger V, Eveno E, Mariage-Samson R, Camarca A, Auffray C, Piatier-Tonneau D, Imbeaud S: A functional and regulatory network associated with PIP expression in human breast cancer.
Vranic S, Schmitt F, Sapino A, Costa JL, Reddy S, Castro M, Gatalica Z: Apocrine carcinoma of the breast: a comprehensive review.
Honma N, Takubo K, Akiyama F, Sawabe M, Arai T, Younes M, Kasumi F, Sakamoto G: Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.
Honma N, Takubo K, Arai T, Younes M, Kasumi F, Akiyama F, Sakamoto G: Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast.
Eusebi V, Millis RR, Cattani MG, Bussolati G, Azzopardi JG: Apocrine carcinoma of the breast. A morphologic and immunocytochemical study.
Vranic S, Tawfik O, Palazzo J, Bilalovic N, Eyzaguirre E, Lee LM, Adegboyega P, Hagenkord J, Gatalica Z: EGFR and HER-2/neu expression in invasive apocrine carcinoma of the breast.
Farmer P, Bonnefoi H, Becette V, Tubiana-Hulin M, Fumoleau P, Larsimont D, Macgrogan G, Bergh J, Cameron D, Goldstein D, Duss S, Nicoulaz AL, Brisken C, Fiche M, Delorenzi M, Iggo R: Identification of molecular apocrine breast tumours by microarray analysis.
Doane AS, Danso M, Lal P, Donaton M, Zhang L, Hudis C, Gerald WL: An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen.
Sanga S, Broom BM, Cristini V, Edgerton ME: Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family.
von Minckwitz G, Blohmer JU, Raab G, Löhr A, Gerber B, Heinrich G, Eidtmann H, Kaufmann M, Hilfrich J, Jackisch C, Zuna I, Costa SD: In vivo chemosensitivity-adapted preoperative chemotherapy in patients with early-stage breast cancer: the GEPARTRIO pilot study.
von Minckwitz G, Kümmel S, Vogel P, Hanusch C, Eidtmann H, Hilfrich J, Hilfrich J, Gerber B, Huober J, Costa SD, Jackisch C, Loibl S, Mehta K, Kaufmann M: Intensified neoadjuvant chemotherapy in early-responding breast cancer: phase III randomized GeparTrio study.
von Minckwitz G, Kümmel S, Vogel P, Hanusch C, Eidtmann H, Hilfrich J, Hilfrich J, Gerber B, Huober J, Costa SD, Jackisch C, Loibl S, Mehta K, Kaufmann M: Neoadjuvant vinorelbine-capecitabine versus docetaxel-doxorubicin-cyclophosphamide in early nonresponsive breast cancer: phase III randomized GeparTrio trial.
von Minckwitz G, Blohmer JU, Costa SD, Denkert C, Eidtmann H, Eiermann W, Gerber B, Hanusch C, Hilfrich J, Huober J, Jackisch C, Kaufmann M, Kümmel S, Paepke S, Schneeweiss A, Untch M, Zahm DM, Mehta K, Loibl S: Response-Guided Neoadjuvant Chemotherapy for Breast Cancer.
Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, Dowsett M, Fitzgibbons PL, Hanna WM, Langer A, McShane LM, Paik S, Pegram MD, Perez EA, Press MF, Rhodes A, Sturgeon C, Taube SE, Tubbs R, Vance GH, van de Vijver M, Wheeler TM, Hayes DF: American Society of Clinical Oncology; College of American Pathologists. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer.
Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC: American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.
Loibl S, Müller BM, von Minckwitz G, Schwabe M, Roller M, Darb-Esfahani S, Ataseven B, du Bois A, Fissler-Eckhoff A, Gerber B, Kulmer U, Alles JU, Mehta K, Denkert C: Androgen receptor expression in primary breast cancer and its predictive and prognostic value in patients treated with neoadjuvant chemotherapy.
Huo L, Zhang J, Gilcrease MZ, Gong Y, Wu Y, Zhang H, Resetkova E, Hunt KK, Deavers MT: Gross cystic disease fluid protein-15 and mammaglobin A expression determined by immunohistochemistry is of limited utility in triple-negative breast cancer.
Lewis GH, Subhawong AP, Nassar H, Vang R, Illei PB, Park BH, Argani P: Relationship between molecular subtype of invasive breast carcinoma and expression of gross cystic disease fluid protein 15 and mammaglobin.
Weigelt B, Horlings HM, Kreike B, Hayes MM, Hauptmann M, Wessels LF, de Jong D, Van de Vijver MJ, Van't Veer LJ, Peterse JL: Refinement of breast cancer classification by molecular characterization of histological special types.
Pagani A, Sapino A, Eusebi V, Bergnolo P, Bussolati G: PIP/GCDFP-15 gene expression and apocrine differentiation in carcinomas of the breast.
Fritzsche FR, Thomas A, Winzer KJ, Beyer B, Dankof A, Bellach J, Dahl E, Dietel M, Kristiansen G: Co-expression and prognostic value of gross cystic disease fluid protein 15 and mammaglobin in primary breast cancer.
Luo MH, Huang YH, Ni YB, Tsang JY, Chan SK, Shao MM, Tse GM: Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas.
Hall RE, Clements JA, Birrell SN, Tilley WD: Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in androgen receptor-positive breast tumours.
Lakhani S, Ellis IO, Tan PH, van de Vijver MJ: WHO Classification of Tumors of the Breast. Lyon: IARC Press; 2012.
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Handbook of human systems integration, Volume 1
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01 product description
Product description
Together with Konstantin Grcic, Flötotto has developed the innovative PRO chair, designed to support the user's freedom of movement by allowing various sitting positions. PRO's most characteristic feature is the chair's S-shaped shell that enables a dynamic yet comfortable sitting experience. The special shape of the shell is based on recent studies into the area of 'Active Sitting' in schools. Originally designed for use in educational environments, the PRO chair with its lightweight and welcoming appearance is also suited for use in other object and private interiors due to its superb functional qualities. The worldwide launch of this line of universal chairs, which come in six attractive colours and five different frame designs, will take place at imm cologne in January 2012.
PRO's unique comfort is based on three main qualities: firstly, the round seat is formed similar to that of a stool and therefore does not force the body forwards. Secondly, the slim backrest allows the torso to move sideways. The third and most decisive aspect is the distinct S-shape of the backrest: the lower curve allows freedom of movement and takes strain away from the lower back and the pelvis. The three-dimensional shape provides structural stability, thus making it possible to produce the plastic shell without using fibreglass for reinforcement and having the additional benefit of significantly increased recycling options. The backwards bend of the upper part of the backrest encourages frequent change of sitting positions and also provides the option of sitting in a straddling position. "With PRO, we have created a chair that meets the latest requirements for school furniture while, due to its specific characteristics, it can also be used as a normal chair in various other settings", is how Grcic sums it up.
PRO Details
• Chair coillection for use in schools and in the private and commercial sectors
• Plastic shell made of 100% polypropylene, available in 6 colours: snow white, graphite black, granite grey, aqua blue, coral red and kiwi green
• Frame designs: C frame (for use in schools) made of tubular steel, four-legged frames in tubular steel or wood, sled base frame in tubular steel, height-adjustable 5-star swivel base frame
(with castors)
• Various accessories for use in commercial sectors (seat padding, row connectors, trays, large range of glides etc.)
• School furniture series, initially available in 3 sizes according to DIN EN 1729: size 4 (primary school), size 5 and 6 (different ages up to 6th form / high school graduates); further sizes to be available in future
• Matching tables in sizes 4 to 6 are available for use in schools
02 awards
reddot design award 2012 WINNER
interior innovation award 2012 WINNER
German Design Award 2013 NOMINEE
Designpreis der Bundesrepublik Deutschland 2013 NOMINEE
iF product design award 2013
German Design Award 2014 GOLD
03 All PRO Products
04 TagsChairs, Design Culture, fairs, Flötotto Articles, Flötotto Products, imm cologne 2012, Konstantin Grcic Articles, Konstantin Grcic Products
05 Articles about Flötotto and Konstantin Grcic
Out on
the roof, too
Product Design students of École Cantonale d'Art de Lausanne had a go at outfitting "Appartement 50" in Marseille's "Cité Radieuse". The result is an homage to Le Corbusier that uses plenty of color and adaptable furniture.› To the article
Four legs and a seat shell
Yes, folks, it really does exist: the universal chair of 2015. It was designed by various hands, comes in numerous versions and yet still follows a typology going back to a famous forebear. Ultimately, it is the subtle differences that count.› To the article
Industry is not a dinosaur
On irony, provocative designs, Chair One as a grill, finding treasure troves, the necessity of securing contracts and the fun of advancing existing designs.
Konstantin Grcic in conversation with Thomas Wagner – part 3› To the article


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Vernal is the known as the gateway to Dinosaur National Monument. And don't get me wrong, I'm always game for a national park—but I would have come all that way just to see the pink concrete dinosaur. (Priorities, right?)
Category: Animal-Vegetable-Mineral
Blushing brontosaurusVernal, UT
Pink picnicHalifax, NS, Canada
Posted 1 month ago
BirdlandCentral Valley, CA
Posted 2 months ago
I've written about California's Central Valley before, and I have a feeling it'll come up again. But there are just so many things to love about the place. Perhaps the best part of all is the birdwatching. The Central Valley is a main thoroughfare along the Pacific Flyway, and hosts thousands upon thousands of both… More
Vort daglige brødPoulsbo, WA
Posted 2 months ago
Like the town of Solvang in California, there's a Scandinavian town in my neck of the woods, too. Except in contrast to Solvang, I love Poulsbo. Even though it's a bit of a tourist trap, Poulsbo feels more humble, more down-home, more real. Its Norwegian roots run deep—I have even heard Norwegian spoken on the… More
Soup's onBuellton, CA
Posted 2 months ago
Now this is more like it. Solvang might have seemed a little too much like a polished Disneyland for my taste, but in the next town over was something much more my speed. Though its name has changed slightly over the years, Pea Soup Andersen's has been a Santa Ynez Valley institution for over 90… More
Residential rosesPortland, OR
Posted 3 months ago
June is the month of roses in the Pacific Northwest, and there's no better place to see roses than the City of Roses. And there's no better rose garden in the City of Roses than the diamond gardens in Ladd's Addition. So in honor of my favorite Portland neighborhood, here are two midsummer sketches, done… More
Splendor and sequinsMission Hills, Los Angeles, CA
Posted 3 months ago
This is the fifth installment of my Mission Mondays series, exploring all 21 Spanish Missions along the California coast. You can read more about this series, and see a sketch map of all the missions, at this post. Last week we visited one of the more unassuming missions in the chain. Just over in the… More
Pea-cocktailDavenport Hotel, Spokane, WA
Posted 4 months ago
I'm not generally into bars, but the Northwest is full of vintage cocktail lounges that are often a hoot in the theme-decor department. The Peacock room at the Davenport Hotel might just take the kitsch cake. The stuffed albino bird and sensory-assaulting wallpaper greet you at the door, but that's just the beginning. Not pictured:… More
Dinner with ShiroShiro's Sushi, Seattle, WA
Posted 5 months ago
Note: I think this might be a first on this blog—showing you a drawing I did only in (gasp!) pencil. But the night I did this sketch, I only had a regular notebook with me, and I needed to work fast—there wasn't time to dig around in my bag for a pen, so I reached… More
Four-legged harbormasterFriday Harbor, San Juan Island, WA
Posted 5 months ago
When I sat on the pier to do this sketch, I only meant to draw the boats—I'm a sucker for bunches of masts and linear elements like tielines. To make sure I could fit the whole mast in the picture plane, I started at the top and worked my way down. It wasn't until I… More


text: I see so many recent good reviews, but i don't get it. They are either fake reviews or are from people that stay in dives. I gave a not so great review to a La Quinta last November, but i would have preferred that place over this one. American Inn is a decent brand with some good properties. I like... More


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Nexus 7 revisited: How Google's latest tablet has held up over the past year
Google Nexus Devices
- Nexus 6 deep-dive review: A supersized smartphone that shines
- Nexus 9 deep-dive review: Bigger, but not necessarily better
- Nexus 6 vs. Galaxy Note 4: Which one's right for you?
- Nexus 6 vs. Galaxy Note 4: Smartphone camera shootout!
If you believe the rumors, we're on the brink of seeing a brand new Google Nexus tablet -- one with a nearly 9-in. screen, an all-aluminum body, and HTC as its manufacturer.
The notion is certainly intriguing. Google has partnered up with a variety of companies to give us standout "pure Android" tablets in recent years, and combining Google's software instincts with HTC's design chops could make for a very compelling device.
With the prospect of a new Nexus ahead of us, I thought it'd be a good time to take a fresh look at the current Google Nexus tablet -- the Asus-made Nexus 7 (2013 model). The Nexus 7's been out for just over a year now, which is enough to feel like an eternity in our fast-moving mobile tech world.
I bought the new Nexus 7 shortly after its release last summer and have had it in my home, hands, or backpack ever since. So a year after its arrival, how has the tablet held up?
Some scattered thoughts:
• No two ways about it: The Nexus 7 is still my favorite tablet on the market today. Like Motorola's Moto X, it doesn't have the most premium-looking design -- but what it does have is a warm and comfortable form that's a pleasure to use.
The tablet's soft-touch plastic backing feels great to the touch. It's proven to be durable, too, with no degradation in quality over the past year -- and while it may be a bit on the plain side in terms of design, it's still a million times better looking than the cheap- and chintzy-looking products at the top of the Android tablet market today.
• Combined with its thin and light profile, the tablet's 7-in. size makes it small enough to hold comfortably in a single hand. Heck, I can even fit the thing in my pocket. Whenever I test other tablets, the Nexus 7 is always refreshing to return to partially for that reason.
I used to be pretty skeptical about the 7-in. tablet size, but this gadget and its predecessor have absolutely won me over. It's a nice balance of screen space and comfort -- something I very much miss when I use a larger tablet.
• Speaking of the Nexus 7's predecessor, that tablet -- the original 2012 model -- made a good first impression but started to show its age quickly after its release. A big part of that was due to the device's performance: For whatever reason, the original Nexus 7 started to feel sluggish after you'd used it for a while. There were plenty of theories as to why, but what mattered from a consumer perspective was that the tablet just wasn't as fast as it needed to be.
The current Nexus 7 is a different story. The tablet is still speedy as can be and no less responsive than when I first got it. Even with the advances we've seen in mobile processing technology over the past months, it remains one of the smoothest and snappiest devices around.
• Another area where the Nexus 7 has outlasted its predecessor is in the realm of display quality. The original Nexus 7's screen was okay but not great -- and a year after its release, many of us found ourselves jonesing for something a little bit better.
With its 323-pixel-per-inch 1080p display, the current Nexus 7 remains a treat for the eyes. You can talk about Quad HD all day, but for a device of this size, full HD resolution looks fantastic and is every bit as impressive now as it was a year ago.
• Software continues to be an area where the Nexus 7 shines. Review after review will tell you the same thing about today's leading Android tablets: They're held back by bloated, ugly, and overly ambitious software.
Being a Nexus device, the Nexus 7 runs an unmodified version of Google's Android software -- which means it's clean, simple, and intuitive. And beyond that, it actually gets updates fast and frequently. When the meaty Android "L" release hits this fall, that'll be an enormous benefit of this device compared to most manufacturers' efforts.
All considered, a year later, there's really very little to complain about with the Nexus 7 -- especially when you consider its $229 price tag. It may not be the newest gadget on the block, but when a friend or family member asks for a personal recommendation, it's still the one I most frequently suggest.
Now let's see if/when the rumored HTC-made sequel arrives -- and if it manages to maintain the tradition.
More Android Power revisitations:
• Moto X revisited: One year with the 'new' Motorola's first flagship phone
• HTC One (M8) revisited: 4 months later, does the phone still impress?
Hands on: The ThinkPad Yoga 11e Chromebook could be the oneNext Post
Android Power's 3 favorite things for August 2014
Google's Nexus 5 offers a high-end Android experience at a low unlocked price -- but is it worth...
With a rumored replacement on the way, it's time to revisit Google's current Nexus tablet to see...
iPhone 6s rumors say Apple will unveil 3D Touch Display on 9/9. Its secret sauce is Force Touch on...
Samsung's back with its fifth-generation phone-tablet hybrid.
Samsung's throwing another phablet into the ring, but this one's curved on both sides.
Sponsored by Intel
Sponsored by Intel
White Paper
White Paper
The SHA-1 hashing algorithm, still used to sign almost one in three SSL certificates, can now be...
At The New York Times, as with its rivals, speeding up web page load times on smartphones is a...
Google's Android 6.0 Marshmallow release is full of fresh new features and flavors. Here's a detailed...
Google for Work is celebrating the first anniversary of its name change from Google Enterprise. The...


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Tegan and Sara, The Jane Doze Rock Long Island for HRC
July 26, 2013 by Maureen McCarty, HRC Deputy Director of Marketing
Last night HRC members and supporters packed into The Paramount in Huntington, Long Island to rock for equality with Tegan and Sara and The Jane Doze.
The Canadian indie-pop duo, Tegan and Sara, are currently on tour with fellow HRC supporters fun., but took a break in their tour schedule to help support HRC in the fight for equality.
The band played a 45-minute set combining music from both their most recent album and older chart-toppers before sitting down with Amanda Leigh Dunn of The Real L Word for a question and answer segment.
In Canada, marriage equality has long been a reality. However, Sara reminded the audience of the work that still lies ahead for LGBT Americans.
"[The Supreme Court victories] are a huge part of the process of moving forward to making sure everybody in the United States has equality," said Sara. "But it's still a massive fight, so we can't get too side tracked on celebrating,."
Currently, 13 U.S states, plus the D.C., legally recognize same-sex marriage.
Special guest DJs The Jane Doze wrapped up the show with a high-energy dance party, bringing a few members of the audience onstage to rock with them.
Thank you to all who turned out to support HRC. Last night's benefit would not have been possible without The Paramount, which donated its beautiful space in support of equality, HRC Board of Governor Lauren Verrusio, the Greater New York Steering Committee and the HRC membership outreach team.
For more videos and photos from last night's event visit @HumanRightsCampaign on Instagram. And for more from musicians and artists who support marriage equality and the Human Rights Campaign visit www.hrc.org/EqualityRocks.
Top Posts
Time to Celebrate: National LGBT Pride Month
June 1, 2015
Frequently Asked Questions about the Upcoming Marriage Equality Case at the U.S. Supreme Court
April 24, 2015
Be Ready to Rally on Decision Day
June 15, 2015
What's at Stake: Potential for Nationwide Marriage Equality Following Supreme Court Ruling
June 5, 2015
Watch: HRC Answers Your SCOTUS Questions
June 19, 2015


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£895,000 Guide Price
Guide Price £895,000
4 bedroom detached house for sale Highlands Hill, Mayland, Chelmsford, Essex, CM3Longacre is a unique country residence, located on an idyllic plot in excess of 4 acres (stls) which includes a stunning private lake. The main residence offers 4 bedrooms, kitchen/breakfast room, garden room, living and dining rooms. Various outbuildings including 2 bedroom annexe, summer house,... More details ›
4 bedroom detached house for sale Highlands Hill, MaylandSituated on a superb rural plot in excess of 4 acres with lake and wooded areas is this versatile detached house and separate bungalow. There are numerous outbuildings including a lodge, a swimming pool room and a garage and hot tub room.. More details ›
Guide Price £650,000
5 bedroom detached house for sale Esplanade West, Mayland, Essex, CM3Offering stunning river views is this impressive five bedroom, detached home is offered for sale with the benefit of having no onward chain. EPC C More details ›
Guide Price £650,000
5 bedroom detached house for sale Esplanade, Maylandsea, EssexSTUNNING VIEWS OF THE RIVER for this impressive FIVE bedroom detached home with CARRIAGE DRIVEWAY offering parking for numerous cars. The property is ideal for entertaining with a welcoming Southerly aspect rear garden and pool area with changing area and covered area ideal for a barbeque and sea... More details ›
Guide Price £650,000
5 bedroom detached house for sale Esplanade, Mayland, CM3WITH STUNNING RIVER VIEWS TO FRONT ASPECT - this fantastic detached property has been much improved and is positioned in an unrivalled position, simply perfect for anyone looking for a superb waterside retreat. Energy Performance Certificate - C More details ›
£600,000 Guide Price
Guide Price £600,000
4 bedroom detached house for sale Esplanade, MaylandseaA unique 4 bedroom modern detached family home occupying a delightful waterside position with views over the Blackwater Estuary | plot of approximately 0.5 acres with direct waterside frontage | fantastic lifestyle property | 4 bedrooms | 2 reception rooms plus separate study and breakfast roo... More details ›
Added on 29/10/2014 by Fenn Wright, Chelmsford Sales. Call: 01245 930127 Local call rate
4 bedroom detached house for sale Princes Avenue, Mayland, CM3A large detached modern FOUR BEDROOM family home with INDOOR HEATED SWIMMING POOL. Spacious accommodation including an Impressive kitchen/diner measuring 34'3, generous entrance hall, large living room, separate dining room & study. SEE FLOOR PLAN & PHOTO'S to find out more about this deceptive home More details ›
4 bedroom detached house for sale Nipsells Chase, Mayland, Chelmsford, CM3Impressive Architect designed 4 Bedroom house set within generous plot with open views to the rear. Traditionally built to the current vendors specification in 2000 this unusual property truly deserves an appointment to view in order to appreciate this unique family home.... More details ›
4 bedroom detached house for sale Nipsells Chase,Mayland,CM3AN IMPOSING INDIVIDUALLY DESIGNED property offering exceptional accommodation including a stunning reception hallway, contemporary open plan kitchen/breakfast room & utility, lounge, dining room, study, four double bedrooms, two en en-suites plus family bathroom. Outside this wonderful home More details ›
5 bedroom detached house for sale Bakersfield The Drive, Mayland, Chelmsford, CM3** NO ONWARD CHAIN ** Executive style FIVE BEDROOM DETACHED family home located in the riverside village of Mayland. Boasting a wealth of fine features this spacious family accommodation has two en suites, study, family room, downstairs cloakroom, kitchen/breakfast room, large P shaped Victorian ... More details ›
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Search Results for "colman's dry mustard"
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Dry-Rubbed Flank Steak with Grilled Corn Salsa
This spicy and sweet powerhouse seasoning blend packs layers of flavor onto grilled flank steak.
Printed: September 2015 Servings: 4 active: 40min total: 50min
The Ultimate Guide to Summer
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Salmon Niçoise
We love making this salad with mâche instead of traditional frisée.
Printed: April 2015 Servings: 6
Las Vegas
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The New Healthy 2015
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Skirt Steak with Shallot Pan Sauce
A seared piece of meat might sound boring. But when it's drizzled with a silky reduction? Always exciting.
Printed: January 2015 Servings: 4 active: 35min total: 35min
Our Ultimate Holiday Guide
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Out of the Kitchen
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The Summer Grilling Manual: Videos, Recipes, & More
This summer, learn how to grill like a pro with these videos—featuring editor in chief Adam Rapoport—and recipes for steaks, kebabs, barbecue, and corn...
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Chef Watson with Bon Appétit: Cognitive Cooking Technology
The home for all stories and recipes about Chef Watson, the IBM–Bon Appétit collaboration to develop better, more sophisticated cognitive cooking technology...
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I got my first thumb in this thread. I think someone clicked my name by mistake, but WHHEEEE!!!!!
Thank you sir!
Ridethecliche is something I came up with in highschool where I felt that everyone was just doing whatever was expected of them and going entirely with the grain and I thought they were riding the cliche's or (stereotypes) that were ascribed to them. I started using it as an online handle. I also used to use SGT.PEPPERS sometimes when playing games haha.
I would lengthen the pants. Also, I like their texture but imo they cry out for a cuff! I hope there is enough fabric to add length and perhaps a 1.75 - 2 inch cuff. Aim for no socks visible when standing, I think they should still touch the shoe.
Also, I think wool socks are those pants' best friend. :)
Too much grey up top imo. I think a standard light blue shirt would do wonders here. Now that I say that, is the shirt gray or is it blue? It looks gray to me. also, I prefer a vest or sweater vest with bow ties, but this is very much just my personal opinion.
Remember gray odd jackets are hard to pair. A navy SC might work a lot better here.
I like the shoes, but they feel a little "dressy" compared to the rest of the fit. It may be a small difference, but perhaps a perfed blucher would serve you better than a bal here.
There's about 2 inches of fabric there, so I don't think I'll be able to cuff them. I should have just enough to let out almost all of it to get a tiny bit of break.
The shirt is actually a faded blue and gray. I was contemplating the plain light blue, but figured that I'd layer patterns for fun. I'm still on the look for a good navy SC. I've been hitting dead ends lately, but I'm sure one will turn up in the next month or so as I thrift.
I think you're right on the shoes. I should have grabbed my black wingtips, though I think brown captoes would have worked well with this as well. I have these really worn brown captoes that I want to pair with these pants once I get one of my tweed blazers back from the tailors.
Thanks for the suggestions!
RTC, this is much better than what I've seen before! I like the styling behind this, though it does scream "GreyFit" If you're going for a seasonal getup, may I suggest some fall/wintery colors : Ambers, Fall greens and such...just a suggestion but overall great job putting this fit together.
Thanks. I'll try this same outfit with a brighther shirt next time. Maybe a burnt orange shirt. I'll mull it over.
I should have submitted this to the monotone challenge! Heh.


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Colliers Hotel
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Theatre day
... lunch in Chinatown and it was bloody awful. Beechworth Chinese has nothing to worry about.
After Stomp we sat in the elfresco area of a pub in Picadilly circus and watched the freaks walk by.
Went to Michael Jackson musical which was excellent except for the guy in front of us who had the worst B O in the history of the world. The little kid that played the 8 year old Jackson was amazing.
Fitbit Tells us we walked 16 kilometres ...
My legs are about to drop off!!
Today was another big day full of walking! I am surprised that our shoes are so in tact! It is really easy to walk around London. It looks like a bit of distance between each landmark or area we want to see but then within half hour you can be on the other side of the Thames. Today we caught the tube to London Hill station and started at the London Tower. It is massive!! We walked around the tower and then over the Tower Bridge which ...
M&Ms and a girl called Cath
... 25.5599994659424px;">31 Cath m&me
So you remember how late I got to bed last night. Well I got up at 7.
Today one of my best friends, Cath (sister of housemate Chris in Scotland) was coming to London for the day.
I was starting work at 12...so who decided it would be a clever thing to go for breakfast? Me.
It was a Nelson day
... in to catch up after at the day's end so we decided to have a meal. The meal. We started with a charcuterie for two (gluten free). As we are in London I felt duty bound to order the bangers and mash, Greg had pasta and this was all washed down with a Californian Zinfandel. We walked to back to Joan's lovely flat in the mild autumn evening to find the usual bland television available on UK free to air television. It makes us appreciate our ABC even more. Good night ...
DAY 3: Friday, 5 September 2014
... having heard we decided to call. Well, first, finding a phone box that didn't stink of urine was near impossible. One had what looked like human faeces in it. Disgusting. Eventually we did find one and I made the call. The automated message suggested I call back another time as they were experiencing extreme delays. Being concerned that it was late on a Friday afternoon. And not being sure whether they would deliver luggage on the weekend, I decided to continue to ...


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APN - Seattle U Fall 2013
0 Hi everyone,
I am applying for Fall 2013 Direct Entry at Seattle University. Anyone else applying?
About rainkissedleaves
From 'Where I am meant to be'; Joined Jan '12; Posts: 315; Likes: 52.0Jul 18, '12 by celticsgirl17I think so! I m just thrown off by the algebra prerequisite. I only needed to take stats for undergrad and I'm not sure my school even has algebra
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Hidden in the scattered grey and brick pattern of a building on Madison and 84th Street is a heart shape containing the letters I + R. I first noticed it a few years ago looking up for a second out of a cab window which just happened to be framing the secret message in such a way that it became easily discernable. I couldn't believe I had never noticed it before.
My initial google research has yielded only this: an entry from Christopher Gray's Streetscapes/Readers' Questions section of The New York Times, published December 2, 2001
The Mystery of I + R
Q: On a building at 84th Street and Madison Avenue there's something very odd. Built into the brick, it says "I + R". It has white and gray bricks. Who is "I" and who is "R"? . . . Aaron B. Scheinfeld, Horace Mann School, the Bronx.
A: The building at 40 East 84th Street was designed in 1962 by Horace Ginsbern for the developers Jack Resnick and Philip Rosen. But the letters do not appear on Ginsbern's elevation drawings, because it was not Ginsbern who specified the monogram in the brick.
According to Mr. Rosen, the letters memorialize his father, Isadore Rosen, a bricklayer who became a developer and who died just before this building was put up.
"He started building on his own account in 1929, a building on Macombs Road in the Bronx, and Mr. Ginsbern was his first architect," Mr. Rosen said. "Even though my father was a big contractor, every day he liked to go out and work with the men for about 15 or 20 minutes and lay a few bricks. The men respected him as someone who had worked his way up."
Mr. Rosen recalled that one day while the 84th Street building was being put up, Carmine Barella, a bricklayer who had long worked with the elder Mr. Rosen, surreptitiously arranged the gray brick with the elder Rosen's initials within a field of white glazed brick in a way that could not be detected until the areas were washed down.
The younger Mr. Rosen is still active in real estate, especially in Florida, and recalls the fine-tuning he put into the design of 40 East 84th Street. "It's got three colors: two shades of gray, and white," he said. "We wanted something a little different, not just plain white, and we wanted a prestigious building."
What would the senior Mr. Rosen have thought if he had lived to see his initials on the facade? "He would have appreciated the thought, but he wasn't the type of man to be boastful," his son said. "He probably would have been a little embarrassed. He might have had it chopped out." But his son left it in place.
It's a sweet story, but does anyone else find it less than totally convincing? It most clearly looks like it reads I plus R. Traditionally, in a heart, this would mean I loves R, or at least indicate the union of two separate entities, not including the union of first name and surname.
I thought the symbol between the letters might have been meant to be a period and that there was no way to avoid its resembling a cross. But! If this were the case, would there not be a second period after the R?
Perhaps it really respresents a love that dare not speak its name…


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Keeping photo printer as default for photos only
Started May 9, 2012 | Discussions thread
Shop cameras & lenses ▾
Senior Member • Posts: 5,093
WHen you print from Photoshop CS% or higher, and you are done setting up your settings and printer it will ask you te re save the image. The next time you print that same image it will remember the same setting as well as the printer used. But NO it will not as a general situation , associate itself with a specific printer. That option only exists with the operating system.
Qimage remembers what printer you asign to a job and unless you change the settings it will choose that printer regardless of which one is your "Default" one.
That is the reason among many why I choose to do all of my image printing with Qimage and nothing else.
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Originally posted on Fox Sports North | Last updated 1/20/13
ST. PAUL, Minn. (AP) -- Dany Heatley had two power-play goals on assists from new teammate Zach Parise, and the offense-enhanced Minnesota Wild surged into their much-anticipated season with a 4-2 victory over the Colorado Avalanche on Saturday. Mikael Granlund also scored for the Wild in his first NHL appearance, Pierre-Marc Bouchard had a late goal in his first game in more than a year and Niklas Backstrom made 25 saves to help make the amped-up crowd of 19,298 forget all about the 119-day lockout that delayed the opener by 3 months. John Mitchell scored early in his debut for the Avalanche and Cody McLeod cut the lead to one with 14:51 remaining in the game, but they were done in during a penalty-ridden second period that had goalie Semyon Varmalov on his heels. After Steve Downie was called for cross-checking, Parise's wrist shot bounced off Varmalov's blocker and back to Heatley, who knocked in the rebound and watched it graze the crossbar on the way in. Just 53 seconds late...
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Delft3D Open Source Community
This webportal facilitates the Delft3D Community to come together to share knowledge, brainstorm on new features and build working relationships.
Delft3D is Open Source Software. To enhance collaboration, to combine the unique expertise of researchers worldwide and to further expand the modelling suite, the source code of Delft3D 4 Suite can be downloaded. The following modules are available: FLOW + MOR + WAVE + WAQ (DELWAQ) + PART. Click here to get started.
| The launch of the Delft3D Flexible Mesh Suite 2016 will take place during the
Delft Software Days (DSD-INT 2015) at this year's Symposium 'Next Generation Hydro Software (NGHS)'
on Tuesday, 3 November 2015, the day before the Delft3D user meeting.
For support and assistance, Deltares offers a wide range of additional Services. One of them is to facilitate connecting to Delft3D users and developers worldwide. We would therefore also like to invite you to join the Delft3D open source group on LinkedIn. In our goal to improve the interaction within the community you are kindly requested to upload your personal photo to your account.
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Photo Galleries
< MyNorthwest
Thursday in photos
Sept. 26: Grand Central Station, models on a collision course, chipping from the rough
2 of 18
Karl-Johan Persson, CEO of Swedish fashion retailer Hennes & Mauritz, speaks during a press conference with Nils Vinge, Head of Investor Relations, left, in Stockholm, Sweden, Thursday Sept. 26, 2013. Fashion retailer Hennes & Mauritz AB says its third-quarter profit swelled by nearly a quarter thanks to strong sales, particularly in China and Japan, and the popularity of its summer collections. (AP Photo/TT News Agency/Marc Femenia)
Photo by Marc Femenia
Photo by Marc Femenia
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Week in photos
Photos taken by the Associated Press Sept. 28 to Oct. 2.
Stargazers treated to supermoon eclipse
Stargazers were treated to a rare astronomical phenomenon with a total lunar eclipse combined with a so-called supermoon.
Week in photos
Photos from the Associated Press taken from around the world.
Four killed in Aurora Avenue Bridge crash in Seattle
The four people killed when a charter bus and Ride the Ducks vehicle collided were students from North Seattle College, The Seattle Times reports.
Big-name business leaders meet China's president in Seattle
Business leaders from Apple, Honeywell, Disney, Microsoft, Starbucks, Dow Chemical, Amazon, IBM, and many more attended a Wednesday morning meeting with the president of China.
Week in photos
Photos taken from around the world during Sept. 14-18.
Week in photos
Check out the week in photos from all over the world.


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Card Case have been gleefully opening tabs and making plastic-free payments at select merchants since May. Starting today, iPhone users will now save precious seconds of shopping time as opening tabs has been automated -- as soon as you're close enough to designated establishments, tabs open themselves courtesy of new geo-fencing APIs exposed in iOS 5. For those who are unfamiliar, the previous iPhone and Android apps required users to manually open those tabs from within the vicinity of a Square-approved merchant. After that, users complete purchases as before by simply confirming their name to a store clerk. That's one more step in society's never-ending quest for frictionless payments, but those with an evil twin or a stalking doppelgänger might want to think twice before joining the Square revolution.
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Members of the recently busted Russian spy ring certainly aren't going to win any awards for the most innovative use of advanced technology. Contrary to the popular image of agents armed with suitcases full of James Bond-like gadgetry, most spies — these Russians included — still use many tried-and-true tools of the trade, such as Morse code and shortwave radio.
Reports of the alleged spies' bumbling with the laptops and software they did have can't be the proudest moment for their bosses at the SVR, Russia's foreign intelligence agency and an offshoot of the KGB. However, their frustration isn't unique.
The spy ring "faced some of the common security problems that plague many companies — misconfigured wireless networks, users writing passwords on slips of paper and laptop help-desk issues that take months to resolve," writes Tim Greene in Network World.
They got some mileage out of steganography, a technique for hiding text messages in innocent-appearing digital images — say of a cat or a sunset — that can be exchanged on the Web. However, the software they used was not the most sophisticated available, writes Sally Adee on Tech Talk, a blog by the editors of IEEE Spectrum.
"Instead of leaving behind an artifact of your wrongdoing for the Justice Department to download, new programs [called network steganography] use ephemeral channels that disappear when the communication has been completed," Adee wrote.
Besides the traceability shortcoming, the image-based steganography programs that the Russians used are not efficient. "The rule of thumb is that you can use 10 percent of a carrier file's size to smuggle data," write Józef Lubacz, Wojciech Mazurczyk and Krzysztof Szczypiorski in a February article in IEEE Spectrum. "For an ambitious steganographer, that could be a problem."
The newer network steganography programs are equally adept at using audio and video files as message carriers. A single six-minute song, saved as an MP3, occupies 30M, enough to conceal every one of Shakespeare's plays, the authors wrote.
Spy agencies are often needled for being too tradition bound. But sometimes practices stick around for a good reason — they work. Shortwave radio signals and coded messages are still surprisingly effective and used not only by the Russians but also by spies from Israel and Great Britain, writes Brett Sokol on Slate.
About the Author
John Zyskowski is a senior editor of Federal Computer Week. Follow him on Twitter: @ZyskowskiWriter.
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A'dia Mathies
Kentucky Wildcats guard A'dia Mathies was fouled by Mississippi State... Fotografia de notíciasA'dia Mathies,Adulto,Basquetebol Feminino,Basquetebol universitário feminino,Desporto,EUA,Kentucky,Kentucky Wildcats,Lexington,Mississippi State Bulldogs,Mississippi State Lady Bulldogs,Mulheres,NCAA,NCAA College Basketball,Partida - Desporto,Rupp Arena,Universidade de Kentucky,VerticalPhotographer Lexington Herald-LeaderCollection: Tribune News Service 2013 MCTKentucky Wildcats guard A'dia Mathies (1) was fouled by Mississippi State Bulldogs guard Katia May (11) during a women's college basketball game at Rupp Arena on Thursday, January 17, 2013 in Lexington, Kentucky. Kentucky defeated Mississippi State, 100-47. (Mark Cornelison/Lexington Herald-Leader/MCT via Getty Images)


text: Bruno Vincent, Getty Images [ Should Lubbock Residents Be Allowed to Own Chickens? [POLL] By Chad Hasty April 3, 2015 KFYO Poll of the Day. Read More|Comment Category: Polls Tags: lubbock city council Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text: Jazz Caliente Latin Jazz, Brazilian and Cuban Music in Seattle By Robin Lloyd • May 7, 2015 http://palmierimusic.com/ Here's our periodic listing of Latin Jazz, Brazilian and Cuban music coming to Seattle, get out and enjoy! Earshot Preview: Miguel Zenón's 'Identities Are Changeable' By Robin Lloyd • Nov 6, 2014 miguelzenon.com Saxophonist Miguel Zenón has taken on some interesting projects in his career. He's a founding member of the SF Jazz Collective, a Kennedy Center jazz ambassador and the recipient of both a Guggenheim and a MacArthur fellowship. He's also the founder of Caravana Cultural, a program designed to bring free-of-charge jazz concerts and educational presentations to rural areas of Puerto Rico. It involves both the best of New York's jazz players and young Puerto Rican musicians. Zenón's latest recording "Identities Are Changeable" (11/4/2014 Miel Music) is inspired by the idea of national identity as viewed or experienced by the Puerto Rican community in the United States, specifically in New York City. A Unique Musical Blend: Pablo Menendez And Mezcla, Direct From Cuba By Robin Lloyd • Sep 18, 2014 B. Leyva Guitarist Pablo Menéndez takes fusion to the next level. His band Mezcla (meaning "mixture") blends jazz, blues, rock and several styles of Cuban and African music into one raucous, joyous expression of life. The Rhythm That's A Way Of Living By Frannie Kelley • Jun 26, 2014 Martin Cohen Listen Listening... / 5:08 Compared to American rock and roll, Afro-Cuban music sounds complicated to the point of intimidation. Sure the rhythms make you want to move, but if you stop to think about what's going on, your feet won't know what to do. And that's just the point — some rhythms are better felt than counted off. NPR's Frannie Kelley learned how easy they can be to play, once you abandon a central tenet of rock: the one. It's All About Family For Juan de Marcos And The Afro-Cuban All Stars By Robin Lloyd • Jun 5, 2014 Michael Hoefner I had a delightful telephone chat last week with Juan de Marcos, leader of the Afro Cuban All Stars. Known as the "Quincy Jones of Cuba," Juan de Marcos comes from a family of musicians. His father was a well-known singer with famed tres player and bandleader Arsenio Rodriguez, and his uncle, Ruben Gonzalez, was one of Cuba's most beloved pianists. Juan grew up with some of the finest Cuban musicians visiting and playing music in his home. Candido Camero Honored At Jazz Education Network Conference By Robin Lloyd • Feb 13, 2014 salsa.com The Jazz Education Network (JEN) created a new award called "Keepers of the Flame: LeJENds of Latin Jazz." Presented at the annual JEN Conference in January, the award's first recipient was NEA Jazz Master Candido Camero. Earshot Jazz Festival Preview: Bill Anschell's Peru Trio By Robin Lloyd • Nov 14, 2013 Steve Korn Pianist, composer, arranger, humorist and world traveler Bill Anschell brings his "Peru Trio" to the Art of Jazz series at the Seattle Art Museum tonight at 5:30. It's part of the Earshot Jazz Festival. This Week's Latin Jazz News By Robin Lloyd • Nov 7, 2013 youtube Latin jazz flutist Dave Valentin suffered a stroke in March 2012, and has been unable to work since then. A benefit concert will take place tonight, Nov. 7, at the Tarrytown Music Hall in Tarrytown, N.Y. The show will help raise funds to pay his medical expenses and basic living needs. Earshot Jazz Festival Preview: An Interview with Omar Sosa By Robin Lloyd • Nov 4, 2013 David Sproule Cuban-born pianist, composer and bandleader Omar Sosa received a lifetime achievement award from the Smithsonian Associates in Washington, DC in 2003 for his contribution to the development of Latin jazz in the United States. His latest CD Eggun (spirit guides) grew from a commission by the Barcelona Jazz Festival in 2009. The idea was to pay tribute to Miles Davis' seminal album, Kind of Blue, on its 50th anniversary. Earshot Jazz Festival Preview: SF Jazz Collective By Robin Lloyd • Oct 17, 2013 Jamie Tanaka, sfjazz.org The SFJAZZ Collective is an all-star jazz ensemble comprising eight of the finest performer/composers at work in jazz today. Launched in 2004, the ensemble annually performs a new list of compositions by a modern jazz master and new pieces by the Collective members. Earshot Jazz Festival Preview: Dafnis Prieto By Robin Lloyd • Oct 10, 2013 dafnisonmusic.com The Cuban-born drummer/percussionist, bandleader and composer Dafnis Prieto appears at the Earshot Jazz Festival next Thursday, October 17 at the Poncho Concert Hall at Cornish College for the Arts, with his Si o Si Quartet: Peter Apfelbaum (saxophone/melodica/caxixi), Robert Rodriguez (piano) and Johannes Weidenmueller (bass). Remembering Oscar; Celebrating Latin Grammys By Robin Lloyd • Oct 3, 2013 oscarcastroneves.com Oscar Castro Neves 1940-2013 A founding figure in the development of Bossa Nova, Brazilian guitarist, composer and arranger Oscar Castro Neves died on September 27. Latin Jazz at Seattle's Earshot Jazz Festival By Robin Lloyd • Sep 26, 2013 SFJazz For the next few weeks on the Jazz Caliente blog, I'll feature previews of the Latin jazz artists appearing at this year's Earshot Jazz Festival, October 1 through November 17. Latin Jazz Birthdays: Turre and Lynch By Robin Lloyd • Sep 12, 2013 Tomoji Hirakata Today is the birthday of two outstanding jazz artists who have years of experience in the Latin jazz format: Local Latin Jazz Lineup By Robin Lloyd • Sep 5, 2013 Anita Kalikies / yoshis.com Opportunities to hear some wonderful live Latin music are popping up in the area this month, and also at the Earshot Jazz Festival in October and November. Here's a starter list, more will follow in the coming weeks: Arturo Sandoval to Receive Medal of Freedom By Robin Lloyd • Aug 29, 2013 tswartz / Flickr Arturo Sandoval will be honored this year with the Presidential Medal of Freedom, the highest civilian award in the United States. "The Presidential Medal of Freedom goes to men and women who have dedicated their own lives to enriching ours," said President Obama in a statement. "This year's honorees have been blessed with extraordinary talent, but what sets them apart is their gift for sharing that talent with the world. It will be my honor to present them with a token of our nation's gratitude." Cedar Walton's Latin Tinge By Robin Lloyd • Aug 22, 2013 wikipedia Pianist and composer Cedar Walton died this week, at the age of 79. He was perhaps best known for his years with Art Blakey's Jazz Messengers (1961-1964), where he presented some of his compositions that became jazz standards, like Ugetsu (Fantasy in D), Firm Roots, Bolivia and Mosaic. He also recorded with John Coltrane on the famous Giant Steps album, but his alternate take of the title track was not released until a CD reissue many years later. Wayne Wallace and the Bay Area Latin Music Scene By Robin Lloyd • Aug 8, 2013 David Belove Wayne Wallace is a trombonist, a five-time Grammy nominee, a respected proponent of African American-Latin music, and an accomplished arranger, educator, and composer. His playing and recording credits are impressive, too: Pete Escovedo, Santana, Tito Puente, Steve Turre, Max Roach and more. The San Francisco native took some time from his busy schedule last week to talk with me about his latest CD, Latin Jazz-Jazz Latin and an upcoming project. Another Maestro Passes: Steve Berrios 1945-2013 By Robin Lloyd • Aug 1, 2013 Johan Broberg Master drummer and percussionist Steve Berrios died last week at age 68. He leaves a legacy of inspirational jazz and Latin music, and a large number of devoted friends who call him their musical father. Mambo Madness with the Spanish Harlem Orchestra By Robin Lloyd • Jul 25, 2013 Atael Weissman / Latin Jazz Network This Sunday, July 28, the award-winning Spanish Harlem Orchestra presents a dance concert in the Sculpture Garden of the Museum of Latin American Art in Long Beach, CA. Live Latin Jazz and Dance Music This Week and Next By Robin Lloyd • Jul 18, 2013 Centrum Foundation Grammy Award winner and Latin Grammy Lifetime Achievement honoree Poncho Sanchez and his Latin Jazz Band return to Seattle's Jazz Alley tonight through Sunday, July 21. The misunderstood drum By Robin Lloyd • Jul 11, 2013 ehow.com The Name What North Americans call conga drums are actually "tumbadoras." Where are the high honors for America's Latin Jazz artists? By Robin Lloyd • Jul 4, 2013 Lane Pederson Looking over the list of the recently announced 2014 National Endowment for the Arts Jazz Masters prompted me to search through the history of the awards for any Latin Jazz artists who have been so honored. Historical Latin jazz in book, CD compilation By Robin Lloyd • Jun 27, 2013 latinjazznet.com Puerto Rican-born valve trombonist Juan Tizol was a major force in Duke Ellington's orchestra. With his classical training, an ability to transpose on the spot, skills as a copyist, sight-reader, proofreader of scores and as a composer, he was indispensable to the band. Carlos Cascante y su Tumbao: Jazz Caliente ... Live! By Justin Steyer & Robin Lloyd • Jun 6, 2013 Justin Steyer / KPLU Listen Listening... / 24:25 Listen to the full interview and performance Every Thursday afternoon at 2 p.m. KPLU jazz host, Robin Lloyd, presents a feature called Jazz Caleinte—a set of three Latin jazz songs that are embellished by Robin's comments and insights into all forms of Latin and Afro-Cuban jazz. Recently Robin hosted her first live Jazz Caliente session with vocalist, Carlos Cascante, and his band, Tumbao. Hilton Ruiz tribute, Arsenio Rodriguez honored By Robin Lloyd • Jun 6, 2013 youtube.com Latin Jazz pianist Hilton Ruiz died in New Orleans in 2006 from unexplained injuries. He left behind an unfinished musical project that was to have benefited Hurricane Katrina victims. Marco Matute has launched a PledgeMusic project that will produce the CD that Hilton intended, along with a documentary film about Hilton Ruiz. Here's a preview of the film. And here's some of Hilton's music: Two new Latin Jazz recordings to anticipate! By Robin Lloyd • May 23, 2013 wikipedia To be released this spring (date TBD): Gonzalo Rubalcaba's Volcan This band is comprised of musical masters, experienced bandleaders and good friends: Jose Armando Gola-bass, Horacio "El Negro" Hernandez-drums, Giovanni Hidalgo-congas and Gonzalo Rubalcaba-piano. Local Latin Jazz Forecast By Robin Lloyd • May 16, 2013 Kathleen Gillette Two upcoming not-to-be missed performances of Latin jazz, Seattle-style: Thursday May 16 (tonight) Tula's, 2214 Second Avenue Fred Hoadley's Sonando Jazz Caliente salutes 2013 JJA winners By Robin Lloyd • May 2, 2013 wikipedia The Jazz Journalists annual awards for musicians were announced yesterday, May 1. Jazz Caliente celebrates Latin Jazz winners Luciana Souza (Best Female Vocalists), Bobby Sanabria (Best Percussionist), and Edmar Casteneda (Player of Instruments Rare in Jazz of the Year). Jazz Caliente celebrates Jazz April, part 2 By Robin Lloyd • Apr 25, 2013 goldstar.com Jazz April birthday celebrations continue on Jazz Caliente! Pages1 2 3 next › last »