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Kristen Pacheco
Hi There- I'm Kristen and I'm the Live Events and Promotions Manager here at Fun107 and WBSM. Most of my posts will be event-related or daily distractions- you're welcome for that!
If you're from the Greater New Bedford Area you've probably been to a few of Joe Jesus' popular 50's Night held each July in Downtown, New Bedford. This is the 24th year that good ol' Joe is holding the event and like every year before it, it promises to be the biggest one yet. "It just keeps growing every single year!" This year's event will be Thursday, July 16th with festivities started at 5pm.
In true Dave Matthews Band form, Big Eyed Phish won't tell us a single song they are going to play at Sun of a Beach. While every DMB jam is a good one, we hope that these three songs are definitely included.
If you live in the area, you know that each summer some newsworthy sea creature is spotted along our shores and becomes the main event for the next day or two. However, in 2007, an unidentified sea creature had a Fall River couple thinking they were going to die in the waters of a Rhode Island beach.
Each Wednesday I try to sneak out of work a smidge early so I can catch up with my family and friends at Apponogansett Park for Dartmouth's Summer Concert Series. What occurred to me this past Wednesday was that not only did i have zero idea about what music i was going to be hearing, but I had zero idea of who the band even was and yet, here I am, rushing around to get there on time! What is it about music outdoors that gets people so excited?
It wasn't long after the YES vote came through for the proposed New Bedford Casino that Facebook commenters began discussing how the casino is going to take away from the downtown businesses. Nobody was very specific about how the business would potentially suffer so we hit the streets to ask them ourselves.
Is there really any other way to spend America's holiday than by watching fireworks with your family and friends, being thankful to live in the land of the free, home of the brave?
WCVB/Channel 5 in Boston has reported a tornado watch for nearly the entire state of Massachusetts through 11pm tonight (Tuesday, June 23.)
This year's Sun of a Beach Music Festival has two great bands whose music has surely stamped a time in your life. For us, Bob Marley has been a huge part of our lives and wanted to make it a huge part of our summer, too, and that's why we're bringing in Bob Marley & The Wailers tribute band Hope Road.
In 1957, Fitchburg, Massachusetts native Don Featherstone created a plastic pink flamingo and forever changed the landscape of the American home.
Officials in Oak Bluffs on Martha's Vineyard are warning residents and visitors after a child from out of state was diagnosed with measles after his visit to the islands last week.
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Martial Arts Dandenong
Victoria > Dandenong Directory > Sports and Recreation > Dandenong Martial Arts
Your search returned 7 Dandenong Martial Arts listings
Dandenong Martial ArtsBasic Listings
Wing Chun Kung Fu AcademyPhone: (03) 9792 5275 Address: 1st Floor, 9 Langhorne Street, Dandenong, VIC | Report
Australian Shukokai-karate-doPhone: (03) 9794 6005 Address: 113 Box Street, Dandenong, VIC | Report
Moon Lee Tae Kwon DoPhone: (03) 9706 9211 Address: 158 Cheltenham Road, Dandenong, VIC | Report
Nos TaekwondoPhone: (03) 9850 3771 Address: Dandenong Street, Dandenong, VIC | Report
Parkside Fight Club And Fitness CentrePhone: 0433 109 433 Address: 4 Dandenong Street, Dandenong, VIC | Report
Ultimate Martial Arts AcademyPhone: (03) 9701 3873 Address: Fcty5/ 17 Hazel Avenue, Dandenong, VIC | Report
A I ProfessionalPhone: 0406 991 734 Address: Unit 5 82 Clow St, Dandenong, VIC | Report
Martial Arts in DandenongIf you own a business in Dandenong and would like to have your business listed here then add your business to the guide. You can get a Classic Listing where you will be able to feature your business including a photo, opening hours, specials and more in our Dandenong Martial Arts directory.
Related terms: Dandenong aikido, Dandenong brazilian jiu jitsu, Dandenong combat martial arts, Dandenong grappling, Dandenong hapkido, Dandenong jiu jitsu, Dandenong jujitsu, Dandenong karate, Dandenong kendo, Dandenong kick boxing, Dandenong kickboxing, Dandenong krav maga, Dandenong kung fu, Dandenong martial arts academy, Dandenong martial arts clothing, Dandenong martial arts clubs, Dandenong martial arts equipment, Dandenong martial arts instruction, Dandenong martial arts schools, Dandenong martial arts training, Dandenong martial arts weapons, Dandenong mixed martial arts, Dandenong muay thai, Dandenong ninjutsu, Dandenong self defence, Dandenong self defence classes, Dandenong shaolin, Dandenong tae kwon do, Dandenong taekwondo, Dandenong wing chun
Martial Arts in surrounding locationsPrahran Martial Arts St Kilda Martial Arts Rowville Martial Arts Balaclava Martial Arts Oakleigh South Martial Arts
Browse other businesses in Dandenong
Pro Wreck - Auto Parts Recyclers
Phone: 1300 122 277 | Location: 46 Bennet St, Dandenong, VIC
Cars Removed Auto Wreckers - Pro Wreck - Auto Parts Recyclers are a car removal company based in Dandenong, Melbourne. Dispose unwanted auto, and make some cash! Call 1300 122277.
Roth Newton
Phone: (03) 9792 2588 | Location: 88 Frankston Dandenong Road, Dandenong, VIC
Roth Newton - Austailia's Largest Selection of Lift Chairs, Lounge Chairs, Recliners, and Lounge Suites
Phone: 1300 788 382 | Location: 129B Longsdale Street, Dandenong, VIC
At Ridetek we go over and above teaching students how to pass the licencing exam, we teach them how to safely ride their motorcycle to avoid accident and injury.
See the Martial Arts main category for all Martial Arts business listings.

subset: commoncrawl


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The Top 10 In Action Sports
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10Living On The Blood and Urine of Dead Sea Turtles: The Shocking Story of A Sailor Stuck in Hell
Sanük: Seat Kicker - Never Uncomfortable
We've all been there. Stuck in the middle with a @#$% seat kicker behind you. NBD. Because when you wear Sanüks, you're #NeverUncomfortable Find a pair of Sanük Commodores that make you comfortable at www.sanuk.com.
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Ratings based on 22 Verified Reviews
They paid and stayed. We double-checked.
4.9 Room cleanliness
4.7 Service & staff
4.9 Room comfort
4.6 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Couplesby A verified traveler
Posted Jun 23, 2015 on Hotels
Had a lovely stay at this beautiful hotel. Service was great except on Monday morning when everyone appeared uninterested when we arrived for breakfast.
for Familiesby A verified traveler from Western Cape, ZA
Best hotel experience in Cape Town.Posted Jun 22, 2015
Pros: Everything!
Cons: If anything, service in the dining rooms and the bar was slow. We missed a sundowner experience because of that.
Location: Just Google Camps Bay...need I say more?
Absolute fabulous from start to finish. A huge thanks for the reception staff that had the savvy to figure out that we were a family booking into 2 rooms and although Expedia does not afford the luxury to book a minor separate in a room, the hotel staff had put my wife and I in the suite and my daughter in the adjacent room. Great ambiance, great food, great grounds, great walks, great fire places, great staff. We will be back.
for Familiesby A verified traveler
Peaceful havenPosted May 23, 2015 on Hotels
My daughter and I appreciated everyone on the staff. The place is so peaceful. Even with the load shedding, everyone was acommodating. We will be back!!
for Couplesby Max from Logan, UT USA
Wonderful Cape Town experiencePosted May 21, 2015 on Hotels
We stayed for 2 nights and had a great experience. The staff was so friendly, the food was amazing, and the place was very beautiful. We even made use of the excellent Spa onsite. It is close to the beach and shops, and the grounds were fun to explore.
for Business Travelersby A verified traveler
Posted Apr 27, 2015 on Hotels
for Everyoneby A verified traveler from Oxford
Traditional yet modern with great servicePosted Apr 24, 2015
Pros: Staff, food, service, location, facilities...
Cons: When we stayed there was a crane building something in front of the hotel but that wasnt their fault...other than that not a lot really...
Location: Camps Bay beach, bars, restaurants, Robben Island, Table Top mountain; Stellenbosch vineyards; Nordhoeck beach....Cape Town city centre...
Stayed 4 nights with my 19 year old son in a twin in one of the deck rooms so not main hotel - loads of room, modern facilities, large outdoor, private patio with chairs and sun loungers with spectacular views through the trees over the far right hand side of Camps Bay and the beach. Our room was accessed by a rope bridge over a canyon which was great fun. We ate twice in the evening at the hotel - both times excellent food, reasonable prices and great service and divine surroundings in a portico patio at the back of the hotel with views over the gardens and on over Camps Bay - great place to have a beer and watch the sun set...Breakfast was included and small buffet but beautifully done - choice of fresh fruits, yoghurt and cooked - but not your average cooked dishes - Benedict Blondie was a poached egg with bacon on a muffin and a divine sauce... Staff were great wherever encountered - at reception; in the bar for a beer or Jamiesons or in the morning for a legendary 'Lloyd-o-chino' - a cappucino made by Lloyd....always smiling always helpful I wouldnt hesitate in recommending this well kept secret Camps Bay Retreat (and nor would my son!)
for Couplesby Peter from Wokingham, UK
Enchanting boutique hotel minutes from Camps BayPosted Jan 26, 2015 on Hotels
Absolutely delightful and exceeded our expectations. The location is outstanding. You wouldn't know you were so close to Camps Bay being as you are in a huge garden. Can't wait until we return.
for Couplesby A verified traveler
Incredible hotel in perfect locationPosted Dec 29, 2014 on Hotels
The hotel is tucked away from the main road but its just a 5 minute walk through the gardens of the hotel to the beach which is really handy. Our room, in the main house, was huge and the decor was great with a classic feel. The breakfast was really good and the service was brilliant - lots of good recommendations of what to do and where to go both in Camps Bay and the wider area.
for Everyoneby A verified traveler
Best hotel ever stayed inPosted Dec 19, 2014
Hotel is in a beautiful spot with the main house but I'm pleased that I stayed in the deck villa which is accessed via a rope bridge over a gorge. Everything was great from the location, very helpful staff, excellent food to the quality of the room.
for Couplesby A verified traveler from Hertfordshire, UK
Peaceful hotel in heart of the CapePosted Oct 18, 2014
Pros: Location, tranquility, frindliness
Cons: Drop the references to dogs in the literature. Put us off but in reality were not an issue.
Excellent facilities in a quiet hotel in the centre of Camps Bay with evening sunsets across the Atlantic.. Friendly and helpful staff and excellent food. Will return.
Comment from Hotel Management
Mar 30, 2015 by Kirsti Naude, Hotel Management
Good Afternoon, Thank you for taking the time to review Camps Bay Retreat. We appreciate the wonderful feedback and rating and are glad to see that you enjoyed all the aspects of the property. We hope to welcome you back soon. Regards Kirsti Naude Manager
Comment from Hotel Management
Mar 30, 2015 by Kirsti Naude, Hotel Management
Good Afternoon, Thank you for taking the time to review Camps Bay Retreat. We appreciate the wonderful feedback and rating and are glad to see that you enjoyed all the aspects of the property. We hope to welcome you back soon. Regards Kirsti Naude Manager


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Other stores Books & stationery in Doncaster
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The Book People
New Catalogue
Antiquarian & Modern
Christmas 2015
194 Sandringham Road
DN2 5JE Doncaster (South Yorkshire)
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Distance: 1.5 mi
91 Sandringham Road, Intake
DN2 5JA Doncaster (South Yorkshire)
Distance: 1.3 mi
36A Imperial Crescent
DN2 5BU Doncaster (South Yorkshire)
Distance: 0.98 mi
34 Imperial Crescent
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Dior Swimming Pool Eyeshadow Palette ($60.00 for 0.24 oz.) is one of two limited edition summer eyeshadow palettes from the brand, and while Aurora soared, Swimming Pool sinks (couldn't resist!).Read Full Review
Dior Aurora Eyeshadow Palette
Dior Aurora Eyeshadow Palette ($60.00 for 0.24 oz.) is a limited edition five-shade palette for summer. The shades were inspired by the emblems of the French Riviera. It's really rich, deep, and filled with warm tones.Read Full Review
Dior Garden Roses Eyeshadow Palette
Dior Garden Roses Eyeshadow Palette ($59.00 for 0.16 oz.) is a limited edition palette for spring that features five shades of pink, purple, and gray. The new palettes for spring are slightly lighter (0.16 oz. vs. 0.21 oz.) compared to other five-pan palettes, though everything looks to be about the same visually. The texture of the eyeshadows from spring have a drier feel to them, which might be an explanation for the discrepancy in quantity. When I trialed these eyeshadows on the eye (without primer), I managed eight hours with slight fading but no creasing.Read Full Review
Dior Garden Pastels Eyeshadow Palette
Dior Garden Pastels Eyeshadow Palette ($59.00 for 0.16 oz.) is described as "pale pink, buttercup yellow, and luminous greens." It's new and limited edition just in time for spring. It's slightly lighter compared to the usual Dior eyeshadow palette, which has 0.21 oz., while this palette only has 0.16 oz. I suspect it is due to the consistency difference somehow, since it doesn't seem less full or smaller compared to other Dior eyeshadow palettes.Read Full Review
Dior Couture Gold (554) 5 Couleurs Eyeshadow Palette
Dior Couture Gold (554) 5 Couleurs Eyeshadow Palette ($59.00 for 0.21 oz.) is a limited edition palette for the holidays that contains five shades, which tend to skew on the warmer side and keep in the spirit of all things glittery, glam, and metallic.Read Full Review
Dior Rosy Tan (754) Eyeshadow Palette
Dior Rosy Tan (754) Eyeshadow Palette ($58.00 for 0.21 oz.) is the companion quint to Rosy Nude–they read almost day and night to me. They're similar yet not the same. Rosy Tan is darker and deeper overall, but it also has cooler undertones.Read Full Review


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PCI DSS and HIPAA: The Security Standards Share Common Ground
Download Now
Date Added: Aug 2007
Format: PDF
One of the greatest challenges that the electronic transactions industry faces today is the issue of security requirements under various rules and regulations. For most people in the industry, the issue is focused on the specifics of the Payment Card Industry Data Security Standard (PCI DSS), but the issue may be much broader than that. Many other security sets are currently operative and they interface with the merchant population that the industry serves. Federal legislation with security requirements include HIPAA (the Hospital Insurance Portability and Accountability Act) of 1996 Title II, the Graham-Leach-Bliley Act of 1999, ground in the merchant services field.


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Knowledge of one or more Blackbaud products – The Financial Edge is preferred. In this role, you will have the opportunity to learn Blackbaud software and... - Indeed
Consultant will be expected to utilize Blackbaud resources to stay current on fundraising best practices such as the Annual Giving Report, npEngage, and other... - Indeed
Minimum of 3 - 7 years of Blackbaud specific sales experience is preferred. Increasing the Cultural vertical market penetration through the sales of all... - Indeed
We are seeking a dynamic and experienced Client Renewals Specialist to join the MicroEdge division of Blackbaud! The Renewals Specialist is a high profile - Indeed
Familiarity with Blackbaud Merchant Services (BBMS) a definite plus. The Client Success Manager is responsible for the ongoing relationship and retention of the... - Indeed
Prior knowledge of or experience working with Blackbaud products strongly preferred. Ability to work independently and produce work that meets the standards of... - Indeed
Knowledge of Blackbaud NetCommunity and other Blackbaud products preferred. Practice Development - Collaborates with other parties throughout Blackbaud to... - Indeed
Comprehensive understanding of Blackbaud products, preferably Luminate Online. Understand customer requirements, level of adoption of the Blackbaud service and... - Indeed
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Work with Blackbaud product management and product development to implement Next Gen Community Foundation software.... - Indeed
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inspiration for celebration
Patriotic Dessert Roundup (Take 2)
- posted in:
- Creative Food
- July 4th / Patriotic
While working on the 4th of July dessert roundups this year, it quickly became clear that Martha deserved a post all to herself! There were just too many great ideas to choose from in her Red, White, and Blue Desserts gallery…here are 8 of my personal fav's: Pictured at at top: Individual Red, White, and […]
Patriotic Dessert Roundup (Take 1)
- posted in:
- Creative Food
- July 4th / Patriotic
Looking for some patriotic treats to serve up this weekend? Check out these colorful, berry-licious ideas from 'round the web! Pictured at top: fresh & healthy Red, White, and Blue Parfaits, Berry-Lemon Napolean featuring lucious lemon filling & flaky pastry, and Cinnamon Candied Apples displayed on tray of blueberries – all from BHG.com.
Today over at Simply Stated – check out some colorful garden party ideas to help inspire your summer celebrations! {Three stylish, floral-inspired partyware collections, plus coordinating drinks, favors, and decor ideas…}
Seaside Wedding + Behind the Scenes!
- posted in:
- Centerpieces & Decor
- Weddings
I'm just loving this gorgeous – and ultra-modern – Seaside Story wedding theme from the knot, so I was really excited to stumble on this knot tv video that gives a "behind the scenes" peek at the photo shoot for this theme!
REAL PARTIES: Star Wars Birthday Party
Attention MOMS… if you have an aspiring young Jedi on your hands, he's guaranteed to love these Star Wars party ideas from Marie LeBaron of Make and Takes! Read on for all the creative details – as told by Marie herself – plus a links to a few Star Wars-inspired craft tutorials on her blog… […]
These fun pics are from a "Pink Lotus Lounge" backyard party that was hosted by sisters & designers Lori Roark and Denise Haynes-Port. This party was held in celebration of a milestone anniversary for their artful, handmade jewelry line: LilyGirl, but it also serves as great inspiration for all sorts of special occasions that you […]


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Welcome to Andrew Nurnberg Associates
ANA was founded in London in 1977. We represent authors from around the world in the fields of literary and commercial fiction and general non-fiction, as well as children's authors. Several have received major prizes, ranging from the International Prize for Arabic Fiction to the French Goncourt.
ANA is proud to represent leading UK and US agent and publisher clients for the sale of translation rights via our offices in the UK and overseas.


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Portland Trail Blazers v Brooklyn Nets
Jared Jeffries of the Portland Trail Blazers puts up a shot over... News PhotoBarclays Center - Brooklyn,Basketball - Sport,Brooklyn - New York,Brooklyn Nets - Basketball Team,Jared Jeffries,Making a Basket,Moving Activity,NBA Pro Basketball,New York City,Portland Trail Blazers,Reggie Evans,Sport,Taking a Shot - Sport,USA,VerticalPhotographer Nathaniel S. ButlerCollection: National Basketball Association 2012 NBAENEW YORK, NY - NOVEMBER 25: Jared Jeffries #1 of the Portland Trail Blazers puts up a shot over Reggie Evans #30 of the Brooklyn Nets on November 25, 2012 at the Barclays Center in the Brooklyn Borough of New York City. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2012 NBAE (Photo by Nathaniel S. Butler/NBAE via Getty Images)


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I am looking for a website that is similar to that of Scrapblog...they partnered up with Mixbooks and I am not liking the change. or i am just not particular fimilar with Mixbooks...either way is there another website comparable to Scrapblog out there...I was in love!!
thanks for the help!


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Grand View Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Continental Breakfast
- Shuttle bus service
- Suites
- Free High-Speed Internet
- Room service
- Swimming pool
Travelers also recommend:
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TripAdvisor Reviews Grand View Hotel Dongguan
Travel Blogs from Dongguan
Caution: Contains Toilet Humor
... which also turned out to be the shower floor. After hearing stories, I am glad I got to experience it in private (I heard in some places, the public toilets are VERY public), but in the shower, too? One challenge at a time please! I never realized how much I move around in the shower until my feet (thankfully in hotel provided sandals) had to be glued to the sides of the squat toilet. My train of thought was something like:
"Please ...
Eighteen hour layover in Guangzhou
... we passed through on the way were very third world looking with rubbish on the roadsides and neglected rundown tennement housing everywhere. It was with a sigh of relief that we pulled into a small side street which lead to a newish looking hotel where we were to stay for 12 hours until we had to return to the airport for the last leg of the trip to Auckland.
Breakfast was included so I ate what ...
... in China, so all that made in china stuff you see, it comes from here. So alongside the manufacturing also comes the shopping. Guangzhou is shopping central. Huge malls, huge wholesale stores. As well as handmade street markets too. There is a huge jade, jewelry and clothing market. Finding quality jade here is a shopper's dream. Finding quality hemp or bamboo clothes for cheap here was impossible for me ...
Dialou Watchtowers
... little pieces here and there resembling french castles, roman architecture, etc. The interior of the watchtowers is completely Chinese. An altar for worship, flat wooden beds, simple kitchens, etc.
I'm really glad I went with 2 Australian guys, one of them owns a garden and sells fruit, so he was pointing out all the wildlife we were walking past. Every kind of edible fruit and ...
Day 8: Guangzhou (in transit), China
... arguably set China on its path to modernization. One of the key sparks for the Opium Wars was the Chinese refusal to allow British traders to enter the city - making the modern comfortable and air conditioned train journey from Hong Kong particularly relevant historically.
Arriving at Guangzhou East train station we first had to pass through the border and get our ...


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Oklahoma City Thunder v Los Angeles Lakers
Kevin Durant of the Oklahoma City Thunder shoots a free throw during... NachrichtenfotoBasketball,Eine Person,Freiwurf,Horizontal,Kalifornien,Kevin Durant,Los Angeles,Los Angeles Lakers,Menschen,NBA,Oklahoma City Thunder - Basketballmannschaft,Profi-Basketball in der NBA,Sport,Sportbegegnung,Staples Center,Trefferversuch,USAPhotographer Harry HowCollection: Getty Images Sport 2013 Getty ImagesLOS ANGELES, CA - JANUARY 27: Kevin Durant #35 of the Oklahoma City Thunder shoots a free throw during the game against the Los Angeles Lakers at Staples Center on January 27, 2013 in Los Angeles, California. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Harry How/Getty Images)


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Future Will Begin by lilcutestarzWatch
©2012-2015 lilcutestarz
My Aunt wore makeup (cake face) for the first time and she just looked O.O
Deviant Art
The Unsure MindI don't know where I am
Who I am
What I am
I don't know if I care to live
Care to others
Or just plainly care at all
I don't know if I envy the world
If I envy that girl
Or possibly the person I can become
I don't know my place
I know that no one does
But for some reason
I am not part of this world
Psychotic to my own nature
Devoured in my own thoughts
Life who are you
Just heed my call
You are the being
In which posses me
Today seen
Tomorrow gone
Like a one life stand
I don't know what is left
I don't know where I belong yet
But when I do
Ill be sure to tell you
Chapter 2: The Gate To TomorrowEver since then, Yesterday had become my new home. Every day I replay that horrific scene over and over again in my mind. What am I so afraid of? Why can't I leave Yesterday and go to Tomorrow? Tomorrow was a portal to possibilities to so called "happiness." I am afraid to move on. To forget my family. I look down and stare at my hands I could still feel the cold hand of my mother touching mine. I shut my eyes as the tear drops fell onto my hands. I missed them so much.
Suddenly, I feel a hand on my shoulder I look up and see a man dressed in light blue. I was a little surprised; people don't normally make contact to one another. I stood up and asked
"Who are you?" I tremble a little at the sudden change of atmosphere. He doesn't say a word. Just nods to follow him. His heels don't click the ground, I am not even sure if he's touching the ground and his hair swayed slightly in every stride. He walks me to the gate and stops next to it. I
The Bird In The CageLet me be free
This cage haunts me
I want to know who I can be
These blue colored walls
And a green halls
Makes me wonder
What would it be like if I fall
But this place is filled with joy
And lots of little toys
For a new baby boy.
His smile is the reason I stay
The reason I began to pray
So that hell never be this way
Trapped in a room
Feeling nothing gloom
Never to meet his doom
Im a bird trapped you see
Where I cant be free
But everyday
I chirp and sing his way
So hell never feel
As though I have gone away
|Sta.sh Submit


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Cinedigm and Demarest Launch Partnership With Release of 'Short Term 12'
The companies will join together for acquisitions, marketing and distribution of independent movies in theaters and the ancillary markets. The first film will be released Aug. 23.
South by Southwest 2013 Grand Jury and audience winner Short Term 12 will be the first movie released under a new co-acquisition and distribution partnership between Demarest Films and Cinedigm, it was announced Tuesday.
Short Term 12, a drama about a twentysomething woman (Brie Larson) working in a foster home, will be theatrically released by Cinedigm on Aug. 23 and will be released in ancillary markets in early 2014. The film also stars Kaitlyn Dever, John Gallagher Jr., Rami Malek and newcomer Keith Stanfield.
The companies envision doing expanded independent film acquisitions, marketing and distribution in the future.
"This arrangement is truly unique as it's not a traditional distribution or production relationship – it's a fully fledged partnership that allows us to share equally in the upsides of our indie films, from theatrical all the way through the vast ancillary opportunities our distribution expertise and infrastructure provides," says Cinedigm CEO Chris McGurk. "It's great to be working with such an innovative team, and this arrangement should expand acquisition opportunities for both parties in the future."
"Cinedigm is on the cutting edge of the independent film renaissance, and we are thrilled to be partnering with them and tapping into the vast potential that digital distribution provides," said Sam Englebardt, co-founder and CEO of Demarest Films, adding: "We expect this to be the first of many films that we co-release with Cinedigm and a model that we are excited to replicate with other distribution partners as well."
Never miss a story. Stay up-to-date with THR's Daily Headlines.
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Cancer Health Center
Extrahepatic Bile Duct Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Unresectable, Recurrent, or Metastatic Extrahepatic Bile Duct Cancer
- General Information About Extrahepatic Bile Duct Cancer
- Cellular Classification of Extrahepatic Bile Duct Cancer
- Stage Information for Extrahepatic Bile Duct Cancer
- Localized Extrahepatic Bile Duct Cancer
- Unresectable, Recurrent, or Metastatic Extrahepatic Bile Duct Cancer
- Changes to This Summary (07 / 31 / 2014)
- About This PDQ Summary
- Get More Information From NCI
Patients with unresectable extrahepatic bile duct cancer have cancer that cannot be completely removed by the surgeon. These patients represent the majority of cases of bile duct cancer. Often a proximal bile duct cancer invades directly into the adjacent liver or into the hepatic artery or portal vein. Portal hypertension may result. Spread to distant parts of the body is uncommon, though transperitoneal and hematogenous hepatic metastases do occur with bile duct cancers of all sites. Invasion along the biliary tree and into the liver is common. Moreover, the majority of patients who undergo resection will develop recurrent disease within the hepatobiliary system or less frequently at distant sites.
Patients with unresectable, recurrent, or metastatic extrahepatic bile duct cancer should be considered for inclusion in clinical trials whenever possible. Information about ongoing clinical trials is available from the NCI Web site.
Recommended Related to Cancer
This complementary and alternative medicine (CAM) information summary provides an overview of the use of Selected Vegetables/Sun's Soup as a treatment for people with cancer. The summary includes a brief history of Selected Vegetables/Sun's Soup and a review of animal and human studies. The information in the Human/Clinical Studies section is summarized in a table located at the end of that section. This summary contains the following key information: "Selected Vegetables" and "Sun's Soup"...
Treatment options:
- Relief of biliary obstruction is warranted when symptoms such as pruritus and hepatic dysfunction outweigh other symptoms from the cancer. When possible, such palliation can be achieved by anastomosis of the bile duct to the bowel or by the placement of bile duct stents by operative, endoscopic, or percutaneous techniques.[1,2]
Palliative radiation therapy after biliary bypass or intubation may be beneficial, and patients may be candidates for inclusion in clinical trials that explore ways to improve the effects of radiation therapy with various radiation sensitizers, such as hyperthermia, radiosensitizer drugs, or cytotoxic chemotherapeutic agents. If a percutaneous catheter has been placed, it can be used as a conduit for placement of sources for brachytherapy.[3,4] Information about ongoing clinical trials is available from the NCI Web site.
- Systemic chemotherapy is appropriate for selected patients with adequate performance status and intact organ function. Fluoropyrimidines, gemcitabine, platinum agents, and docetaxel have been reported to produce transient partial remissions in a minority of patients.
A randomized, phase III study of up to 6 months of gemcitabine versus gemcitabine and cisplatin in 410 patients with unresectable, recurrent, or metastatic biliary tract carcinoma demonstrated an improvement in median overall survival (OS) among patients treated with combination therapy (11.7 months vs. 8.1 months; HR, 0.64; (95% confidence interval, 0.52-0.80); P < .001.[5][Level of evidence: 1iiA] A similar median OS benefit was demonstrated in all subgroups, including 73 patients with extrahepatic bile duct cancer and 57 patients with hilar tumors. Grade 3 and 4 toxicities occurred with similar frequency in both study arms, with the exception of increased hematologic toxicity in patients randomly assigned to gemcitabine-cisplatin and increased hepatotoxicity in patients randomly assigned to single-agent gemcitabine.
In this article
Extrahepatic Bile Duct Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] Topics
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The Journal Sentinel Editorial Board's blog on the day's happenings as they happen
Historic moment for county?
Milwaukee County supervisors have a chance to do something almost historic today. If the board sustains County Executive Chris Abele's vetoes of the county budget this afternoon, the tax levy cut would be the largest approved by the county since 1994.That would be a significant achievement given the fiscal challenges the county faces, and Abele deserves some credit for making those vetoes. »Read Full Blog Post
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The larger issue is the dysfunctional organization of County government. Re-read the Keyes Commission report. Educate readers. Either create a true executive or abolish the position and have the board hire an administrator. Now we have the least (and worst) of both worlds.
We are working on the atucal Itineraries.However, here is a short summary on the March Training:Do your downtown merchants close for business during special events? Do they view them as an inconvenience rather than an opportunity? Have they become business prevention experts? If so, this session will provide many low- or no-cost ideas to help merchants capitalize on your events. You'll get tips on easy things your businesses can do before, during and after events to get "more through the door" when there are lots of "feet on the street". Additionally, information will be provided on how your Main Street program can effectively work with merchants and help them benefit from special events.September Training:We are still working on the summary and will post it as soon as we finish.Keep checking back.
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WobbleWorks announces the world's first 3D printing pen, shipping in September for $50
WobbleWorks has begun a Kickstarter campaign for the world's first 3D printing pen. The group of "serial inventors" hopes to raise $30,000 for the 3D printer alternative.
Priced at $50 for early Kickstart backers, the 200g 3D pen can create 3D objects much like an expensive 3D printer can, except a lot cheaper and easier. No software is needed and users can start drawing whatever they like. Certainly, some pretty cool things can be made.
"We wanted to design a 3D printing device that could be used within minutes, without needing any technical knowledge, software or computers," said Peter Dilworth, co-founder and CEO of WobbleWorks. "We also wanted it to be affordable as well as fun, so that anyone could 3Doodle!"
The group plans to offer stencils and templates for the pen, thanks to the help of artists on Etsy, the online crafts marketplace. A community will also be formed so that deas and designs can be shared.
"We're working with some fantastic Etsy artists to provide limited-edition '3Doodles' as well as templates and stencils to help others create amazing objects," said Dilworth. "We're also creating a 3Doodle community where people can share their ideas, designs and 3Doodles."
WobbleWorks does warn that the 3Doodler is not a toy, as the tip of the pen gets as hot as 270C, powered by a universal 110v or 220v charger. Safety videos will be created, according to the company, although the plastic that comes out of the pen is safe to touch for easy morphing.
The 3Doodler is compatible with 3mm ABS and PLA that is available from several suppliers. For the 3D printing newbies in the crowd, ABS is a common plastic and PLA is made from biodegradable objects like corn and has a lower melting temperature than ABS.
The 3Doodler will begin shipping to Kickstarter backers in September 2013. The $50 package includes the 3D pen and a bag of mixed colour plastic, while the more expensive versions contain more plastic.
At internetmatters.org parents can find all the advice they will need to keep their children safe online. Designed specifically for parents, the site offers a wealth of up-to-date, unbiased information and advice about how to deal with online safety. Parents can learn about the latest issues and technologies, get great tips on how to talk about online safety with their children and get the best advice on dealing with issues and taking action. Created with experts, Internet Matters provides detailed information, but also signposts to best-in-class resources from individual expert organisations. Our goal is to ensure parents can always access the information that they need, in a format that is clear and concise.
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1912-S $10 MS64+ PCGS. CAC....Click the image to load the highest resolution version.
MS64+ 1912-S Ten Dollar
1912-S $10 MS64+ PCGS. CAC. Another in this minihoard of
1912-S eagles certified MS64+ by PCGS. The issue was minted to the
extent of 300,000 coins, but it is one of which neither David Akers
nor Michael Fuljenz, both published authority-experts on 20th
century gold, have much complimentary to say. The usual complaints
are strike, luster, and abrasions.
Reddish Surfaces, Sharply Struck
This MS64+ piece is fairly unabraded nonetheless, with one shallow, nearly vertical mark in center of cheek. The portrait overall, however, is cleaner than normally seen. The fields are lightly marked on each side, including a couple of sharp ticks on the right (facing) wing. Two typical areas for the noted strike weakness are the high-point hair curls just under LI in LIBERTY and the forepart of the eagle's right (facing) wing, and while the former shows minor weakness, the latter is better-detailed than normal, and the lower headdress feathers are also well-struck. The lower reverse shows a bold strike, including the mintmark, claws, and fasces. The slightly granular surfaces host rich, reddish-tinged color. Population: 10 in 64+, 9 finer (9/11).(Registry values: N4719) (NGC ID# 269G, PCGS# 8872)
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The Coinage of Augustus Saint-Gaudens is an issue-by-issue examination of these two artistically inspired series of gold coins.
Each date and mintmark is reviewed with up-to-date information, much of which has never been previously published. The book is based on
two extraordinary collections: The Phillip H. Morse collection and the Dr. and Mrs. Steven L. Duckor collection.
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Publications (180)928.47 Total impact
Article: Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S]2+ Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity.Biochemistry 09/2015; DOI:10.1021/acs.biochem.5b00532 · 3.02 Impact Factor
Article: Identification of Amino Acids at the Catalytic Site of a Ferredoxin-Dependent Cyanobacterial Nitrate Reductase[Show abstract] [Hide abstract]
ABSTRACT: An in silico model of the ferredoxin-dependent nitrate reductase from the cyanobacterium Synechococcus sp. PCC 7942, and information about active sites in related enzymes, had identified Cys148, Met149, Met306, Asp163, and Arg351 as amino acids likely to be involved in either nitrate binding, prosthetic group binding, or catalysis. Site-directed mutagenesis was used to alter each of these residues, and differences in enzyme activity and substrate binding of the purified variants were analyzed. In addition, the effects of these replacements on the assembly and properties of the Mo cofactor and [4Fe-4S] centers were investigated using Mo and Fe determinations, coupled with EPR spectroscopy. The C148A, M149A, M306A, D163N, and R351Q variants were all inactive with either the physiological electron donor, reduced ferredoxin, or the non-physiological electron donor, reduced methyl viologen, as the source of electrons and all exhibited changes in the Mo cofactor. Charge-conserving D163E and R351K variants were also inactive, suggesting that specific amino acids are required at these two positions. The implications for the role of these five conserved active-site residues in light of these new results and previous structural, spectroscopic and mutagenesis studies for related periplasmic nitrate reductases are discussed.Biochemistry 08/2015; DOI:10.1021/acs.biochem.5b00511 · 3.02 Impact Factor
Article: Spectroscopic and Redox Studies of Valence-Delocalized [Fe2S2](+) Centers in Thioredoxin-Like Ferredoxins.[Show abstract] [Hide abstract]
ABSTRACT: Reduced forms of the C56S and C60S variants of the thioredoxin-like Clostridium pasteurianum [Fe2S2] ferredoxin (CpFd) provide the only known examples of valence-delocalized [Fe2S2]+ clusters, which constitute a fundamental building block of all higher nuclearity Fe-S clusters. In this work, we have revisited earlier work on the CpFd variants and carried out redox and spectroscopic studies on the [Fe2S2]2+,+ centers in wild-type and equivalent variants of the highly homologous and structurally characterized Aquifex aeolicus ferredoxin 4 (AaeFd4) using EPR, UV-visible-NIR absorption, CD and variable-temperature MCD, and protein-film electrochemistry. The results indicate that the [Fe2S2]+ centers in the equivalent AaeFd4 and CpFd variants reversibly interconvert between similar valence-localized S = 1/2 and valence-delocalized S = 9/2 forms as a function of pH, with pKa values in the range 8.3-9.0, due to protonation of the coordinated serinate residue. However, freezing high-pH samples results in partial or full conversion from valence-delocalized S = 9/2 to valence-localized S = 1/2 [Fe2S2]+ clusters. MCD saturation magnetization data for valence-delocalized S = 9/2 [Fe2S2]+ centers facilitated determination of transition polarizations and thereby assignments of low-energy MCD bands associated with the FeFe interaction. The assignments provide experimental assessment of the double exchange parameter, B, for valence-delocalized [Fe2S2]+ centers and demonstrate that variable-temperature MCD spectroscopy provides a means of detecting and investigating the properties of valence-delocalized S = 9/2 [Fe2S2]+ fragments in higher nuclearity Fe-S clusters. The origin of valence delocalization in thioredoxin-like ferredoxin Cys-to-Ser variants and Fe-S clusters in general is discussed in light of these results.Journal of the American Chemical Society 03/2015; 137(13). DOI:10.1021/jacs.5b01869 · 12.11 Impact Factor
Article: NsrR from Streptomyces coelicolor is a Nitric Oxide-Sensing [4Fe-4S] Cluster Protein with a Specialized Regulatory Function[Show abstract] [Hide abstract]
ABSTRACT: Get the PDF: http://tinyurl.com/kuq3sbx The Rrf2-family transcription factor NsrR controls expression of genes in a wide range of bacteria in response to nitric oxide (NO). The precise form of the NO sensing module of NsrR is the subject of controversy because NsrR proteins containing either [2Fe-2S] or [4Fe-4S] clusters have been observed previously. Optical, Mossbauer, resonance Raman spectroscopies and native mass spectrometry demonstrate that S. coelicolor NsrR (ScNsrR), previously reported to contain a [2Fe-2S] cluster, can be isolated containing a [4Fe-4S] cluster. ChIP-seq experiments indicated that the ScNsrR regulon is small, consisting of only hmpA1, hmpA2 and nsrR itself. The hmpA genes encode NO-detoxifying flavohaemoglobins, indicating that ScNsrR has a specialized regulatory function focussed on NO-detoxification, and is not a global regulator like some NsrR orthologues. EMSAs and DNaseI footprinting showed that the [4Fe-4S] form of ScNsrR binds specifically and tightly to an 11 bp inverted repeat sequence in the promoter regions of the identified target genes, and that DNA binding is abolished following reaction with NO. Resonance Raman data were consistent with cluster coordination by three Cys residues and one oxygen-containing residue and analysis of ScNsrR variants suggested that highly conserved E85 may be the fourth ligand. Finally, we demonstrate that some low molecular weight thiols, but importantly not physiologically relevant thiols such as cysteine and an analogue of mycothiol, bind weakly to the [4Fe-4S] cluster and exposure of this bound form to O2 results in cluster conversion to the [2Fe-2S] form, which does not bind to DNA. These data help to account for the observation of [2Fe-2S] forms of NsrR. Copyright © 2015, The American Society for Biochemistry and Molecular Biology. http://www.jbc.org/content/early/2015/03/14/jbc.M115.643072.abstract?sid=59e66843-1673-4fad-a549-db5c87978a5cJournal of Biological Chemistry 03/2015; DOI:10.1074/jbc.M115.643072 · 4.57 Impact Factor
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ABSTRACT: BolA proteins are defined as stress-responsive transcriptional regulators, but they also participate in iron metabolism. Although they can form [2Fe-2S]-containing complexes with monothiol glutaredoxins (Grx), structural details are lacking. Three Arabidopsis thaliana BolA structures were solved. They differ primarily by the size of a loop referred to as the variable [H/C] loop, which contains an important cysteine (BolA_C group) or histidine (BolA_H group) residue. From three-dimensional modeling and spectroscopic analyses of A. thaliana GrxS14-BolA1 holo-heterodimer (BolA_H), we provide evidence for the coordination of a Rieske-type [2Fe-2S] cluster. For BolA_C members, the cysteine could replace the histidine as a ligand. NMR interaction experiments using apoproteins indicate that a completely different heterodimer was formed involving the nucleic acid binding site of BolA and the C-terminal tail of Grx. The possible biological importance of these complexes is discussed considering the physiological functions previously assigned to BolA and to Grx-BolA or Grx-Grx complexes.Journal of Biological Chemistry 07/2014; 289(35). DOI:10.1074/jbc.M114.572701 · 4.57 Impact Factor
Article: Spectroscopic evidence for a 5-coordinate oxygenic ligated high spin ferric heme Moiety in the Neisseria Meningitidis hemoglobin binding receptor.[Show abstract] [Hide abstract]
ABSTRACT: Background: For many pathogenic microorganisms, iron acquisition represents a significant stress during the colonization of a mammalian host. Heme is the single most abundant source of soluble iron in this environment While the importance of iron assimilation for nearly all organisms is clear, the mechanisms by which heme is acquired and utilized by many bacterial pathogens, even those most commonly found at sites of infection, remain poorly understood. Methods: An alternative protocol for the production and purification of the outer membrane hemoglobin receptor (HmbR) from the pathogen Neisseria meningitidis has facilitated a biophysical characterization of this outer membrane transporter by electronic absorption, circular dichroism, electron paramagnetic resonance, and resonance Raman techniques. Results: HmbR co-purifies with 5-coordinate high spin ferric heme bound. The heme binding site accommodates exogenous imidazole as a sixth ligand, which results in a 6-coordinate, low-spin ferric species. Both the 5- and 6-coordinate complexes are reduced by sodium hydrosulfite. Four HmbR variants with a modest decrease in binding efficiency for heme have been identified (H87C, H280A, Y282A, and Y456C). These findings are consistent with an emerging paradigm wherein the ferric iron center of bound heme is coordinated by a tyrosine ligand. Conclusion: In summary, this study provides the first spectroscopic characterization for any heme or iron transporter in Neisseria meningitidis, and suggests a coordination environment heretofore unobserved in a TonB-dependent hemin transporter. General Significance: A detailed understanding of the nutrient acquisition pathways in common pathogens such as N. meningitidis provides a foundation for new antimicrobial strategies.Biochimica et Biophysica Acta (BBA) - General Subjects 06/2014; 1840(10). DOI:10.1016/j.bbagen.2014.06.009 · 4.38 Impact Factor
Article: An EPR/HYSCORE, Mössbauer, and resonance Raman study of the hydrogenase maturation enzyme HydF: A model for N-coordination to [4Fe-4S] clusters[Show abstract] [Hide abstract]
ABSTRACT: The biosynthesis of the organometallic H cluster of [Fe-Fe] hydrogenase requires three accessory proteins, two of which (HydE and HydG) belong to the radical S-adenosylmethionine enzyme superfamily. The third, HydF, is an Fe-S protein with GTPase activity. The [4Fe-4S] cluster of HydF is bound to the polypeptide chain through only the three, conserved, cysteine residues present in the binding sequence motif CysXHisX(46-53)HisCysXXCys. However, the involvement of the two highly conserved histidines as a fourth ligand for the cluster coordination is controversial. In this study, we set out to characterize further the [4Fe-4S] cluster of HydF using Mössbauer, EPR, hyperfine sublevel correlation (HYSCORE), and resonance Raman spectroscopy in order to investigate the influence of nitrogen ligands on the spectroscopic properties of [4Fe-4S](2+/+) clusters. Our results show that Mössbauer, resonance Raman, and EPR spectroscopy are not able to readily discriminate between the imidazole-coordinated [4Fe-4S] cluster and the non-imidazole-bound [4Fe-4S] cluster with an exchangeable fourth ligand that is present in wild-type HydF. HYSCORE spectroscopy, on the other hand, detects the presence of an imidazole/histidine ligand on the cluster on the basis of the appearance of a specific spectral pattern in the strongly coupled region, with a coupling constant of approximately 6 MHz. We also discovered that a His-tagged version of HydF, with a hexahistidine tag at the N-terminus, has a [4Fe-4S] cluster coordinated by one histidine from the tag. This observation strongly indicates that care has to be taken in the analysis of data obtained on tagged forms of metalloproteins.European Journal of Biochemistry 11/2013; 19(1). DOI:10.1007/s00775-013-1062-9 · 2.54 Impact Factor
Article: Arabidopsis thaliana Nfu2 Accommodates [2Fe-2S] or [4Fe-4S] Clusters and Is Competent for in Vitro Maturation of Chloroplast [2Fe-2S] and [4Fe-4S] Cluster-Containing Proteins[Show abstract] [Hide abstract]
ABSTRACT: Nfu-type proteins are essential in the biogenesis of iron-sulfur (Fe-S) clusters in numerous organisms. A number of phenotypes including low levels of Fe-S cluster incorporation are associated with the deletion of the gene encoding a chloroplast-specific Nfu-type protein, Nfu2 from Arabidopsis thaliana (AtNfu2). Here, we report that recombinant AtNfu2 is able to assemble both [2Fe-2S] and [4Fe-4S] clusters. Analytical data and gel filtration studies support cluster/protein stoichiometries of one [2Fe-2S] cluster/homotetramer and one [4Fe-4S] cluster/homodimer. The combination of UV-visible absorption and circular dichroism and resonance Raman and Mössbauer spectroscopies has been employed to investigate the nature, properties, and transfer of the clusters assembled on Nfu2. The results are consistent with subunit-bridging [2Fe-2S](2+) and [4Fe-4S](2+) clusters coordinated by the cysteines in the conserved CXXC motif. The results also provided insight into the specificity of Nfu2 for the maturation of chloroplastic Fe-S proteins via intact, rapid, and quantitative cluster transfer. [2Fe-2S] cluster-bound Nfu2 is shown to be an effective [2Fe-2S](2+) cluster donor for glutaredoxin S16 but not glutaredoxin S14. Moreover, [4Fe-4S] cluster-bound Nfu2 is shown to be a very rapid and efficient [4Fe-4S](2+) cluster donor for adenosine 5'-phosphosulfate reductase (APR1), and yeast two-hybrid studies indicate that APR1 forms a complex with Nfu2 but not with Nfu1 and Nfu3, the two other chloroplastic Nfu proteins. This cluster transfer is likely to be physiologically relevant and is particularly significant for plant metabolism as APR1 catalyzes the second step in reductive sulfur assimilation, which ultimately results in the biosynthesis of cysteine, methionine, glutathione, and Fe-S clusters.Biochemistry 09/2013; 52(38). DOI:10.1021/bi4007622 · 3.02 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Monothiol glutaredoxins (Grxs) are proposed to function in Fe-S cluster storage and delivery, based on their ability to exist as apo monomeric forms and dimeric forms containing a subunit-bridging [Fe(2)S(2)](2+) cluster, and to accept [Fe(2)S(2)](2+) clusters from primary scaffold proteins. In addition yeast cytosolic monothiol Grxs interact with Fra2 (Fe repressor of activation-2), to form a heterodimeric complex with a bound [Fe(2)S(2)](2+) cluster that plays a key role in iron sensing and regulation of iron homeostasis. In this work, we report on in vitro UV-visible CD studies of cluster transfer between homodimeric monothiol Grxs and members of the ubiquitous A-type class of Fe-S cluster carrier proteins ((Nif)IscA and SufA). The results reveal rapid, unidirectional, intact and quantitative cluster transfer from the [Fe(2)S(2)](2+) cluster-bound forms of A. thaliana GrxS14, S. cerevisiae Grx3, and A. vinelandii Grx-nif homodimers to A. vinelandii(Nif)IscA and from A. thaliana GrxS14 to A. thaliana SufA1. Coupled with in vivo evidence for interaction between monothiol Grxs and A-type Fe-S cluster carrier proteins, the results indicate that these two classes of proteins work together in cellular Fe-S cluster trafficking. However, cluster transfer is reversed in the presence of Fra2, since the [Fe(2)S(2)](2+) cluster-bound heterodimeric Grx3-Fra2 complex can be formed by intact [Fe(2)S(2)](2+) cluster transfer from (Nif)IscA. The significance of these results for Fe-S cluster biogenesis or repair and the cellular regulation of the Fe-S cluster status are discussed.Dalton Transactions 01/2013; 42(9). DOI:10.1039/c2dt32263c · 4.20 Impact Factor
Article: Spectroscopic and Functional Characterization of Iron-Bound Forms of Azotobacter vinelandiiNifIscA[Show abstract] [Hide abstract]
ABSTRACT: The ability of Azotobacter vinelandiiNifIscA to bind Fe has been investigated to assess the role of Fe-bound forms in NIF-specific Fe–S cluster biogenesis. NifIscA is shown to bind one Fe(III) or one Fe(II) per homodimer and the spectroscopic and redox properties of both the Fe(III)- and Fe(II)-bound forms have been characterized using the UV–visible absorption, circular dichroism, and variable-temperature magnetic circular dichroism, electron paramagnetic resonance, Mössbauer and resonance Raman spectroscopies. The results reveal a rhombic intermediate-spin (S = 3/2) Fe(III) center (E/D = 0.33, D = 3.5 ± 1.5 cm–1) that is most likely 5-coordinate with two or three cysteinate ligands and a rhombic high spin (S = 2) Fe(II) center (E/D = 0.28, D = 7.6 cm–1) with properties similar to reduced rubredoxins or rubredoxin variants with three cysteinate and one or two oxygenic ligands. Iron-bound NifIscA undergoes reversible redox cycling between the Fe(III)/Fe(II) forms with a midpoint potential of +36 ± 15 mV at pH 7.8 (versus NHE). l-Cysteine is effective in mediating release of free Fe(II) from both the Fe(II)- and Fe(III)-bound forms of NifIscA. Fe(III)-bound NifIscA was also shown to be a competent iron source for in vitro NifS-mediated [2Fe-2S] cluster assembly on the N-terminal domain of NifU, but the reaction occurs via cysteine-mediated release of free Fe(II) rather than direct iron transfer. The proposed roles of A-type proteins in storing Fe under aerobic growth conditions and serving as iron donors for cluster assembly on U-type scaffold proteins or maturation of biological [4Fe-4S] centers are discussed in light of these results.Biochemistry 10/2012; 51(41):8056–8070. DOI:10.1021/bi300664j · 3.02 Impact Factor
Article: Spectroscopic and Functional Characterization of Iron–Sulfur Cluster-Bound Forms of Azotobacter vinelandiiNifIscA[Show abstract] [Hide abstract]
ABSTRACT: The mechanism of [4Fe-4S] cluster assembly on A-type Fe–S cluster assembly proteins, in general, and the specific role of NifIscA in the maturation of nitrogen fixation proteins are currently unknown. To address these questions, in vitro spectroscopic studies (UV–visible absorption/CD, resonance Raman and Mössbauer) have been used to investigate the mechanism of [4Fe-4S] cluster assembly on Azotobacter vinelandiiNifIscA, and the ability of NifIscA to accept clusters from NifU and to donate clusters to the apo form of the nitrogenase Fe-protein. The results show that NifIscA can rapidly and reversibly cycle between forms containing one [2Fe-2S]2+ and one [4Fe-4S]2+ cluster per homodimer via DTT-induced two-electron reductive coupling of two [2Fe-2S]2+ clusters and O2-induced [4Fe-4S]2+ oxidative cleavage. This unique type of cluster interconversion in response to cellular redox status and oxygen levels is likely to be important for the specific role of A-type proteins in the maturation of [4Fe-4S] cluster-containing proteins under aerobic growth or oxidative stress conditions. Only the [4Fe-4S]2+-NifIscA was competent for rapid activation of apo-nitrogenase Fe protein under anaerobic conditions. Apo-NifIscA was shown to accept clusters from [4Fe-4S] cluster-bound NifU via rapid intact cluster transfer, indicating a potential role as a cluster carrier for delivery of clusters assembled on NifU. Overall the results support the proposal that A-type proteins can function as carrier proteins for clusters assembled on U-type proteins and suggest that they are likely to supply [2Fe-2S] clusters rather than [4Fe-4S] for the maturation of [4Fe-4S] cluster-containing proteins under aerobic or oxidative stress growth conditions.Biochemistry 10/2012; 51(41):8071–8084. DOI:10.1021/bi3006658 · 3.02 Impact Factor
Article: Reversible cycling between cysteine persulfide-ligated [2Fe-2S] and cysteine-ligated [4Fe-4S] clusters in the FNR regulatory protein[Show abstract] [Hide abstract]
ABSTRACT: Fumarate and nitrate reduction (FNR) regulatory proteins are O(2)-sensing bacterial transcription factors that control the switch between aerobic and anaerobic metabolism. Under anaerobic conditions [4Fe-4S](2+)-FNR exists as a DNA-binding homodimer. In response to elevated oxygen levels, the [4Fe-4S](2+) cluster undergoes a rapid conversion to a [2Fe-2S](2+) cluster, resulting in a dimer-to-monomer transition and loss of site-specific DNA binding. In this work, resonance Raman and UV-visible absorption/CD spectroscopies and MS were used to characterize the interconversion between [4Fe-4S](2+) and [2Fe-2S](2+) clusters in Escherichia coli FNR. Selective (34)S labeling of the bridging sulfides in the [4Fe-4S](2+) cluster-bound form of FNR facilitated identification of resonantly enhanced Cys(32)S-(34)S stretching modes in the resonance Raman spectrum of the O(2)-exposed [2Fe-2S](2+) cluster-bound form of FNR. This result indicates O(2)-induced oxidation and retention of bridging sulfides in the form of [2Fe-2S](2+) cluster-bound cysteine persulfides. MS also demonstrates that multiple cysteine persulfides are formed on O(2) exposure of [4Fe-4S](2+)-FNR. The [4Fe-4S](2+) cluster in FNR can also be regenerated from the cysteine persulfide-coordinated [2Fe-2S](2+) cluster by anaerobic incubation with DTT and Fe(2+) ion in the absence of exogenous sulfide. Resonance Raman data indicate that this type of cluster conversion involving sulfide oxidation is not unique to FNR, because it also occurs in O(2)-exposed forms of O(2)-sensitive [4Fe-4S] clusters in radical S-adenosylmethionine enzymes. The results provide fresh insight into the molecular mechanism of O(2) sensing by FNR and iron-sulfur cluster conversion reactions in general, and suggest unique mechanisms for the assembly or repair of biological [4Fe-4S] clusters.Proceedings of the National Academy of Sciences 09/2012; 109(39):15734-9. DOI:10.1073/pnas.1208787109 · 9.67 Impact Factor
Article: Monothiol Glutaredoxins Function in Storing and Transporting [Fe2S2] Clusters Assembled on IscU Scaffold Proteins[Show abstract] [Hide abstract]
ABSTRACT: In the bacterial ISC system for iron-sulfur cluster assembly, IscU acts as a primary scaffold protein, and the molecular co-chaperones HscA and HscB specifically interact with IscU to facilitate ATP-driven cluster transfer. In this work, cluster transfer from Azotobacter vinelandii [Fe(2)S(2)](2+) cluster-bound IscU to apo-Grx5, a general purpose monothiol glutaredoxin in A. vinelandii, was monitored by circular dichroism spectroscopy, in the absence and in the presence of HscA/HscB/Mg-ATP. The results indicate a 700-fold enhancement in the rate of [Fe(2)S(2)](2+) cluster transfer in the presence of the co-chaperones and Mg-ATP, yielding a second-order rate constant of 20 000 M(-1) min(-1) at 23 °C. Thus, HscA and HscB are required for efficient ATP-dependent [Fe(2)S(2)](2+) cluster transfer from IscU to Grx5. The results support a role for monothiol Grx's in storing and transporting [Fe(2)S(2)](2+) clusters assembled on IscU and illustrate the limitations of interpreting in vitro cluster transfer studies involving [Fe(2)S(2)]-IscU in the absence of the dedicated HscA/HscB co-chaperone system.Journal of the American Chemical Society 09/2012; 134(37):15213-6. DOI:10.1021/ja306061x · 12.11 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Human glutaredoxin 3 (Glrx3) is an essential [2Fe-2S]-binding protein with ill-defined roles in immune cell response, embryogenesis, cancer cell growth, and regulation of cardiac hypertrophy. Similar to other members of the CGFS monothiol glutaredoxin (Grx) family, human Glrx3 forms homodimers bridged by two [2Fe-2S] clusters that are ligated by the conserved CGFS motifs and glutathione (GSH). We recently demonstrated that the yeast homologues of human Glrx3 and the yeast BolA-like protein Fra2 form [2Fe-2S]-bridged heterodimers that play a key role in signaling intracellular iron availability. Herein, we provide biophysical and biochemical evidence that the two tandem Grx-like domains in human Glrx3 form similar [2Fe-2S]-bridged complexes with human BolA2. UV-visible absorption and circular dichroism, resonance Raman, and electron paramagnetic resonance spectroscopic analyses of recombinant [2Fe-2S] Glrx3 homodimers and [2Fe-2S] Glrx3-BolA2 complexes indicate that the Fe-S coordination environments in these complexes are virtually identical to those of the analogous complexes in yeast. Furthermore, we demonstrate that apo BolA2 binds to each Grx domain in the [2Fe-2S] Glrx3 homodimer forming a [2Fe-2S] BolA2-Glrx3 heterotrimer. Taken together, these results suggest that the unusual [2Fe-2S]-bridging Grx-BolA interaction is conserved in higher eukaryotes and may play a role in signaling cellular iron status in humans.Biochemistry 02/2012; 51(8):1687-96. DOI:10.1021/bi2019089 · 3.02 Impact Factor
Article: Arabidopsis Chloroplastic Glutaredoxin C5 as a Model to Explore Molecular Determinants for Iron-Sulfur Cluster Binding into Glutaredoxins[Show abstract] [Hide abstract]
ABSTRACT: Unlike thioredoxins, glutaredoxins are involved in iron-sulfur cluster assembly and in reduction of specific disulfides (i.e. protein-glutathione adducts), and thus they are also important redox regulators of chloroplast metabolism. Using GFP fusion, AtGrxC5 isoform, present exclusively in Brassicaceae, was shown to be localized in chloroplasts. A comparison of the biochemical, structural, and spectroscopic properties of Arabidopsis GrxC5 (WCSYC active site) with poplar GrxS12 (WCSYS active site), a chloroplastic paralog, indicated that, contrary to the solely apomonomeric GrxS12 isoform, AtGrxC5 exists as two forms when expressed in Escherichia coli. The monomeric apoprotein possesses deglutathionylation activity mediating the recycling of plastidial methionine sulfoxide reductase B1 and peroxiredoxin IIE, whereas the dimeric holoprotein incorporates a [2Fe-2S] cluster. Site-directed mutagenesis experiments and resolution of the x-ray crystal structure of AtGrxC5 in its holoform revealed that, although not involved in its ligation, the presence of the second active site cysteine (Cys(32)) is required for cluster formation. In addition, thiol titrations, fluorescence measurements, and mass spectrometry analyses showed that, despite the presence of a dithiol active site, AtGrxC5 does not form any inter- or intramolecular disulfide bond and that its activity exclusively relies on a monothiol mechanism.Journal of Biological Chemistry 06/2011; 286(31):27515-27. DOI:10.1074/jbc.M111.228726 · 4.57 Impact Factor
Article: SufD and SufC ATPase Activity Are Required for Iron Acquisition during in Vivo Fe-S Cluster Formation on SufB[Show abstract] [Hide abstract]
ABSTRACT: In vivo biogenesis of Fe-S cluster cofactors requires complex biosynthetic machinery to limit release of iron and sulfide, to protect the Fe-S cluster from oxidation, and to target the Fe-S cluster to the correct apoenzyme. The SufABCDSE pathway for Fe-S cluster assembly in Escherichia coli accomplishes these tasks under iron starvation and oxidative stress conditions that disrupt Fe-S cluster metabolism. Although SufB, SufC, and SufD are all required for in vivo Suf function, their exact roles are unclear. Here we show that SufB, SufC, and SufD, coexpressed with the SufS-SufE sulfur transfer pair, purify as two distinct complexes (SufBC(2)D and SufB(2)C(2)) that contain Fe-S clusters and FADH(2). These studies also show that SufC and SufD are required for in vivo Fe-S cluster formation on SufB. Furthermore, while SufD is dispensable for in vivo sulfur transfer, it is absolutely required for in vivo iron acquisition. Finally, we demonstrate for the first time that the ATPase activity of SufC is necessary for in vivo iron acquisition during Fe-S cluster assembly.Biochemistry 11/2010; 49(43):9402-12. DOI:10.1021/bi1011546 · 3.02 Impact Factor
Article: Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast[Show abstract] [Hide abstract]
ABSTRACT: The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae. Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis. We have previously shown that Fra2 and Grx3/4 form a [2Fe-2S](2+)-bridged heterodimeric complex with iron ligands provided by the active site cysteine of Grx3/4, glutathione, and a histidine residue. To further characterize this unusual Fe-S-binding complex, site-directed mutagenesis was used to identify specific residues in Fra2 that influence Fe-S cluster binding and regulation of Aft1 activity in vivo. Here, we present spectroscopic evidence that His-103 in Fra2 is an Fe-S cluster ligand in the Fra2-Grx3 complex. Replacement of this residue does not abolish Fe-S cluster binding, but it does lead to a change in cluster coordination and destabilization of the [2Fe-2S] cluster. In vivo genetic studies further confirm that Fra2 His-103 is critical for control of Aft1 activity in response to the cellular iron status. Using CD spectroscopy, we find that ∼1 mol eq of apo-Fra2 binds tightly to the [2Fe-2S] Grx3 homodimer to form the [2Fe-2S] Fra2-Grx3 heterodimer, suggesting a mechanism for formation of the [2Fe-2S] Fra2-Grx3 heterodimer in vivo. Taken together, these results demonstrate that the histidine coordination and stability of the [2Fe-2S] cluster in the Fra2-Grx3 complex are essential for iron regulation in yeast.Journal of Biological Chemistry 10/2010; 286(1):867-76. DOI:10.1074/jbc.M110.184176 · 4.57 Impact Factor
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ABSTRACT: Here we identify a previously undescribed protein, HemQ, that is required for heme synthesis in Gram-positive bacteria. We have characterized HemQ from Bacillus subtilis and a number of Actinobacteria. HemQ is a multimeric heme-binding protein. Spectroscopic studies indicate that this heme is high spin ferric iron and is ligated by a conserved histidine with the sixth coordination site available for binding a small molecule. The presence of HemQ along with the terminal two pathway enzymes, protoporphyrinogen oxidase (HemY) and ferrochelatase, is required to synthesize heme in vivo and in vitro. Although the exact role played by HemQ remains to be characterized, to be fully functional in vitro it requires the presence of a bound heme. HemQ possesses minimal peroxidase activity, but as a catalase it has a turnover of over 10(4) min(-1). We propose that this activity may be required to eliminate hydrogen peroxide that is generated by each turnover of HemY. Given the essential nature of heme synthesis and the restricted distribution of HemQ, this protein is a potential antimicrobial target for pathogens such as Mycobacterium tuberculosis.Journal of Biological Chemistry 08/2010; 285(34):25978-86. DOI:10.1074/jbc.M110.142604 · 4.57 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Here we identify a previously undescribed protein, HemQ, that is required for heme synthesis in Gram-positive bacteria. We have characterized HemQ from Bacillus subtilis and a number of Actinobacteria. HemQ is a multimeric heme-binding protein. Spectroscopic studies indicate that this heme is high spin ferric iron and is ligated by a conserved histidine with the sixth coordination site available for binding a small molecule. The presence of HemQ along with the terminal two pathway enzymes, protoporphyrinogen oxidase (HemY) and ferrochelatase, is required to synthesize heme in vivo and in vitro. Although the exact role played by HemQ remains to be characterized, to be fully functional in vitro it requires the presence of a bound heme. HemQ possesses minimal peroxidase activity, but as a catalase it has a turnover of over 104 min−1. We propose that this activity may be required to eliminate hydrogen peroxide that is generated by each turnover of HemY. Given the essential nature of heme synthesis and the restricted distribution of HemQ, this protein is a potential antimicrobial target for pathogens such as Mycobacterium tuberculosis.Journal of Biological Chemistry 08/2010; 285(34):25978-25986. · 4.57 Impact Factor
Article: Anaerobic sulfatase-maturating enzyme - A mechanistic link with glycyl radical-activating enzymes?[Show abstract] [Hide abstract]
ABSTRACT: Sulfatases form a major group of enzymes present in prokaryotes and eukaryotes. This class of hydrolases is unique in requiring essential post-translational modification of a critical active-site cysteinyl or seryl residue to C(alpha)-formylglycine (FGly). Herein, we report mechanistic investigations of a unique class of radical-S-adenosyl-L-methionine (AdoMet) enzymes, namely anaerobic sulfatase-maturating enzymes (anSMEs), which catalyze the oxidation of Cys-type and Ser-type sulfatases and possess three [4Fe-4S](2+,+) clusters. We were able to develop a reliable quantitative enzymatic assay that allowed the direct measurement of FGly production and AdoMet cleavage. The results demonstrate stoichiometric coupling of AdoMet cleavage and FGly formation using peptide substrates with cysteinyl or seryl active-site residues. Analytical and EPR studies of the reconstituted wild-type enzyme and cysteinyl cluster mutants indicate the presence of three almost isopotential [4Fe-4S](2+,+) clusters, each of which is required for the generation of FGly in vitro. More surprisingly, our data indicate that the two additional [4Fe-4S](2+,+) clusters are required to obtain efficient reductive cleavage of AdoMet, suggesting their involvement in the reduction of the radical AdoMet [4Fe-4S](2+,+) center. These results, in addition to the recent demonstration of direct abstraction by anSMEs of the C(beta) H-atom from the sulfatase active-site cysteinyl or seryl residue using a 5'-deoxyadenosyl radical, provide new insights into the mechanism of this new class of radical-AdoMet enzymes.FEBS Journal 03/2010; 277(8):1906-20. DOI:10.1111/j.1742-4658.2010.07613.x · 4.00 Impact Factor
Top Journals
University of Georgia
Атина, Georgia, United States
- • Center for Metalloenzyme Studies
- • Department of Chemistry
University of South Carolina
Columbia, SC, United States
- Chemistry and Biochemistry
Stanford University
Palo Alto, CA, United States
- Department of Chemistry
Emory University
Atlanta, Georgia, United States
- Department of Physics
Northwestern University
Evanston, Illinois, United States
- Department of Chemistry
Tokyo Metropolitan Institute of Medical ScienceEdo, Tōkyō, Japan
Université de NeuchâtelNeuenburg, Neuchâtel, Switzerland
Texas Tech University
Lubbock, TX, United States
- • Department of Chemistry and Biochemistry
- • Center for Biotechnology and Genomics
Johns Hopkins University
Baltimore, Maryland, United States
- • Department of Chemistry
- • Department of Biology
Virginia Polytechnic Institute and State University
Блэксбург, Virginia, United States
- Department of Biochemistry
Cea LetiGrenoble, Rhône-Alpes, France
Duke UniversityDurham, North Carolina, United States
University of California, Los AngelesLos Ángeles, California, United States
New University of LisbonLisboa, Lisbon, Portugal
University of California, San Francisco
San Francisco, California, United States
- Department of Biochemistry and Biophysics
Princeton University
Princeton, New Jersey, United States
- Department of Chemistry
Louisiana State University
Baton Rouge, Louisiana, United States
- Department of Chemistry
University of East AngliaNorwich, England, United Kingdom


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Texas Tech v Kansas State
- Basketball - Sport
- Basketball Guard
- Big 12
- Big 12 Basketball Tournament
- Bramlage Coliseum
- First Half - Sport
- General View
- Kansas
- Kansas State University
- Kansas State Wildcats
- Making a Basket
- Manhattan - Kansas
- Men's College Basketball
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Guard Jordan Tolbert of the Texas Tech Red Raiders puts up a shot... News PhotoBasketball - Sport,Basketball Guard,Big 12,Big 12 Basketball Tournament,Bramlage Coliseum,First Half - Sport,General View,Kansas,Kansas State University,Kansas State Wildcats,Making a Basket,Manhattan - Kansas,Men's College Basketball,Moving Activity,NCAA,NCAA College Basketball,NCAA College Conference Team,Sport,Taking a Shot - Sport,Texas Tech Red Raiders,Texas Tech University,USA,VerticalPhotographer Peter G. AikenCollection: Getty Images Sport 2013 Peter G. AikenMANHATTAN, KS - FEBRUARY 25: Guard Jordan Tolbert #32 of the Texas Tech Red Raiders puts up a shot against forward Thomas Gipson #42 of the Kansas State Wildcats during the first half on February 25, 2013 at Bramlage Coliseum in Manhattan, Kansas. Kansas State defeated Texas Tech 75-55. (Photo by Peter G. Aiken/Getty Images)


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Learning FreeNAS
Chapter 2: Preparing to Add FreeNAS to Your NetworkBy
Configure and manage a network attached storage solution
- Turn a PC into a Network Attached Storage server with FreeNAS
- Configure, manage, and troubleshoot your FreeNAS installation
- Up to date with the latest FreeNAS release
- Includes a comprehensive troubleshooting section
For more information, visit: http://www.packtpub.com/learning-freenas/book#indetail
Issue 180/2015
Buy this issue as a PDF
Bugzilla Bug
Bug database has a bug of its own that could allow an intruder to create an unauthorized account.
US Launches New Strategy for Broadband Access
Report focuses federal resources on achieving universal Internet access.
RC4 Finally Gets the Fork
Leading browser makers say "no" to porous encryption algorithm
IBM Says TOR Network a Vehicle for Ransomware
Report from the X-Force group says attackers are using TOR to hide their crimes
Mozilla Announces new Firefox API
Future Firefox extensions will be compatible with Chrome.
Weird Security Flaw Affected Intel Chips for 16 Years
Better read this if you bought your computer before 2011
OpenSSH 7.0 Secure Shell Arrives
Users should upgrade to the new version as soon as possible
Qemu Flaw Lets the Guest Escape
Xen project announces a privilege escalation problem for Qemu host systems
Android Bug Threatens Millions of Users
Attackers can compromise an Android phone just by sending a text message
Lenovo and Canonical Announce Laptop Deal
PC vendor will pre-install Ubuntu on portables in India.


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Are you a 1L working through one of your weekly research assignments? Are you doing research for your substantial writing? Do you have research questions for work? If so, we'd like to help you! Manned by trained law students and professional law librarians, The Reference Desk can help you find the resources and answers you are looking for. The desk is open Monday- Friday, 8 AM- 9 PM and Saturday 9 AM-5PM. You can drop by in person, call us at 801-422-6658, or click the "Ask a Librarian" button. We look forward to assisting you.
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BYU Law #1 in Least Debt
BYU Law was #1 in U.S. News's recent "10 Law Schools that Leave Grads with the Least Debt." The article looked at indebtedness of the Class of 2014 and found that BYU Law Grads had an average debt of $54,203, which was less than half the average debt load of the entire Class of 2014 ($111,899).
Welcome, Class of 2018!
The Law Library is happy to welcome the class of 2018 to the law school! We're excited that you're here with us and want you to know that we're here to help you throughout your legal education. In addition to the study carrels and the books you see around you, the law library has many electronic databases available to help you in your studies and research. Check out our website to find many of the great resources available to you. We do our best to keep you up to date on new databases, research tips, and more through our law library blog, Facebook, and Twitter. Please let us know if there's anything we can do to help. Here's a little information for you to get to know us. We look forward to getting to know you!
HeinOnline: Introducing Enhanced Interface 101
HeinOnline has just released a new, enhanced interface that is both modern and fresh. If you are like me you probably loved Hein's content, but did not love the awkward and sometimes confusing site layout. After listening to feedback from its users, HeinOnline now boasts a simplified, clean and update look that is far more intuitive than the previous version. In addition to the improved layout, the new site is mobile friendly, has a stationary search bar and new home button, all making navigation much more user-friendly. Take a minute to jump on and explore the new-and-improved HeinOnline.
New ProQuest Congressional Interface Launched
On July 28th ProQuest Congressional launched its new interface. The fresh new look is both appealing and user-friendly.
Some of the improvements include:
- Home page:quick starting points to help new users connect with popular content
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The addition of social media content allows users to find posts by Senators, Representatives and Federal agencies from Twitter, Facebook, YouTube, blogs and press releases.
Updated Bill Profiles allow users to view bill tracking graphics in their results. The profiles are easy to sort and filter and can be downloaded to spreadsheets. Bill texts and all related materials can be accessed by links. Each profile includes the bill's status, a summary, all versions of the bill text, committees involved and a list of sponsors.
HeinOnline's ALI Library Now Includes Current Content!
Due to a new agreement with the American Law Institute, HeinOnline's ALI Library will now contain current content, including pocket parts. This means that ALI Library users can conduct research by accessing both historical and the most recent materials available. These fully searchable documents include historical content,drafts, current content, pocket parts to help update research, and law review articles. The most current content under each title in the Library will appear in bold type for easy identification.
The organization of the ALI Library has also been aligned with American Law Institute categorizations and a new sub-collection, Current Projects, has been added.
Another helpful feature of the ALI Library on Hein is their Case Law Linking. Case citations are hyperlinked (to Fastcase) within the text and allow researchers to access both historical and recent full text cases.
BYU Law Paper Series now on SSRN
Take a look at the exciting things BYU law faculty members are working on by subscribing to the Brigham Young University J. Reuben Clark Law School Research Paper Series on SSRN.
It's that time again when hotly anticipated orders are being issued by the U.S.' top court. This session the Court is addressing everything from religious rights in the workplace (Equal Employment Opportunity Commission v. Abercrombie & Fitch Stores) to whether or not the Fair Housing Act of 1968 prohibits "disparate impact" (Texas Department of Housing and Community Affairs v. The Inclusive Communities Project, Inc.). Arguably one of the most anticipated issues of recent history focusing on the Fourteenth Amendment and marriage (DeBoer v. Snyder & Tanco v. Haslam) is also being decided.
A great resource for following all of the Court's exciting action is SCOTUSblog. The blog, about all things Supreme Court, is written by members of the legal community including lawyers, law professors and law students. The site live blogs as the Court hears oral arguments and announces opinions. The site also provides comprehensive coverage of all of the cases being argued before the court and maintains individual case archives of briefing and other documents. Bloggers also provide links to PDFs of opinions as they are released by the Court. The Court is expected to release its next set of orders on Monday morning, so tune in to follow all of the developments live!
Statistical Abstracts of the U.S. Reboot
ProQuest's Statistical Abstracts of the U.S. is getting a makeover!
The cleaner, more intuitive interface will go live June 1st
ProQuest has based the upgrade on extensive user testing and feedback. Their goal is to make the interface of Statistical Abstracts an easier and more valuable experience for users.
Other improvements users can expect see include:
- More responsive design making use on any device, mobile or otherwise, smoother
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- Reorganization of the screen to highlight more popular features, making them easier to find
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BYU Law Ranked #22
BYU Law was recently ranked #22 in Above the Law's Top 50 Law Schools for 2015. ATL's ranking looks at employment score, quality jobs score, SCOTUS clerk and federal judgeship scores, education cost, alumni rating, and M7 ratio (debt per job).


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Funny Or Die
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Santa Cum Videos, Santa Cum Pictures, Santa Cum Articles
Santa Claus Is Cumming To Town by Lady Bunnny
Holiday song parodied
Deck the Halls and shut the fuck up!
"deck the halls and shut the fuck up" [Santa's last words] (scroll down for lyrics) You know, there are sometimes when it's time to tell everything by ma...
Death Bed Subtext w/ Topher Grace & Kate Bosworth
When you are on your death bed, it's important to have the ones you love there with you.
A Helping Hand
Tugon the elf has his heart in the right place this holiday season. Yet, he can't help himself from messing things up.
Friendship - Alan Thompkins "Professional Baby Handler"
Alan Thompkins shares his methods on how to properly handle children.
Sponge Bob christmas Dub part 1 of 2
Well guys its finnally here my new SpongeBob christmas Dub enjoy. All Rights Reserved. No Copyright Infrengement Intended.
Sponge Bob christmas Dub part 2 of 2
Second part of the new christmas Dub enjoy evreyone rate & please leave comments from your Facebooks. All Rights Reserved. SpongeBob Sqarepants. is Copyri...
Persian Perversian - Short, Dirty Jokes by Marvin Kharrazi
Adult Humor: Stand Up Comedy featuring short men, tall women and how to tell if you've found true love. By Marvin Kharrazi
5 items
HBOs GIRLS of SILICON VALLEY
Sex Education
How to Use the F Word
Blind Taste Test
Business Work: New Initiative


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Henry Gabriel Cisneros is an American politician and businessman. Cisneros worked as the 10th Secretary of Housing and Urban Development (HUD) in the administration of President Bill Clinton from 1993 to 1997. As HUD Secretary, Cisneros was credited with initiating the revitalization of many public housing developments and with formulating…read more
Larry Claxton Flynt, Jr. is an American publisher, world-renowned defender of First Amendment rights, and Chairman of the Hustler brand of properties. Flynt is the president of Larry Flynt Publications, which consists of over 30 magazines, including Chic, and Barely Legal. Most recently, he released Rage Magazine, which is geared…read more
Juraj Vaculík is the co-founder and CEO of Aeromobil, a tech company planning to release the first flying car by 2017. In 1996 Vaculik founded 'MADE BY VACULIK' - one of the leading independent advertising agencies in the Central Eastern Europe (CEE) region, extending its reach to over 30 countries.…read more
Mignon L. Clyburn served as the Acting Chairwoman of the Federal Communications Commission (FCC), in the interim period between the departure of Julius Gena-chowski and the confirmation of Tom Wheeler. Prior to her nomination to the FCC, she served for 11 years as the representative of South Carolina's 6th congressional…read more
Michael "Mike" Rogers is a CNN National Security Commentator. Rogers served as an officer in the U.S. Army, a special agent in the FBI, and a Michigan state Senator before his election to Congress in 2000. Rogers then served as the U.S. Representative for Michigan's 8th congressional district, from 2001-2015.…read more
Thomas Allen "Tom" Coburn is an American politician and medical doctor. Coburn was elected to the U.S. House of Representatives in 1994, and served through 2001. During his three terms in the House, Coburn played an influential role in reforming welfare and other federal entitlement programs. In 2004, he returned…read more
Lanny J. Davis is an American lawyer, consultant, lobbyist, author and television commentator. From 1996 – 1998, Davis served as advisor and special counsel to former President Bill Clinton, and served on the Privacy and Civil Liberties Oversight Board under President Bush. Davis is currently a Fox News contributor and…read more
Steven R. Peterson had been a Special Agent (SA) of the United States Department of Justice, the Drug Enforcement Administration (DEA) for nearly three decades. Peterson taught over 80,000 law enforcement officers, and has received numerous awards and commendations. Peterson is a nationally recognized expert in Mexican Black Tar Heroin,…read more
William "Bill" Richardson is an American politician who was the 30th Governor of New Mexico, from 2003-2011. Richardson led a distinguished public-service career as a U.S. Congressman (1982-1996), U.S. Ambassador to the United Nations (1997-1998), and Secretary of Energy under President Bill Clinton from 1998-2000. As a diplomat and Special…read more
Steven A. King is the U.S. Representative for Iowa's 4th congressional district, serving in Congress since 2003. King serves on the Agriculture Committee and brings valuable knowledge to Congress as an agribusiness man and small business owner for 28 years. As a member of the House Judiciary Committee, King sits…read more